PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2532055-4	1989	The maintenance of LTP in the LS in slices from Wistar and Long-Evans rats was prevented by D(CH2)5-Tyr(Me)-arginine VP, an antagonist for the V1 type of VP receptors.	Arginine	108-116	arginine vasopressin	Rattus norvegicus	117-119
2573600-5	1989	Calcium-dependent binding was completely inhibited by unlabeled fibrinogen, partially inhibited by a monoclonal antibody (7E3) against glycoprotein IIb-IIIa, but not inhibited by fibrinogen fragments D or E, an anti-glycoprotein IIIa polyclonal antibody, or the Arg-Gly-Asp-Ser tetrapeptide.	Arginine	262-265	fibrinogen beta chain	Homo sapiens	64-74
2692716-8	1989	Protease-cleaved CRP loses the ability to bind to the Ca2+-dependent ligand phosphorylcholine but remains the ability to bind to the Ca2+-independent ligand arginine-rich histone.	Arginine	157-165	C-reactive protein	Homo sapiens	17-20
2573600-6	1989	In contrast, the Arg-Gly-Asp-Ser tetrapeptide as well as the monoclonal antibody 7E3 markedly inhibited attachment of endothelial cells to substrate-immobilized fibrinogen, whereas fragment D or E did not.	Arginine	17-20	fibrinogen beta chain	Homo sapiens	161-171
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	vitronectin	Rattus norvegicus	78-89
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	vitronectin	Rattus norvegicus	203-214
2628423-1	1989	Arg-42 or Lys-43 or Arg-44 of human pancreatic secretory trypsin inhibitor (PSTI) was replaced by Thr or Ser by site-directed mutagenesis, and the inactivation rates of the mutants after mixing with human trypsin were compared with that of the natural form.	Arginine	0-3	serine peptidase inhibitor Kazal type 1	Homo sapiens	36-74
2628423-1	1989	Arg-42 or Lys-43 or Arg-44 of human pancreatic secretory trypsin inhibitor (PSTI) was replaced by Thr or Ser by site-directed mutagenesis, and the inactivation rates of the mutants after mixing with human trypsin were compared with that of the natural form.	Arginine	0-3	serine peptidase inhibitor Kazal type 1	Homo sapiens	76-80
2685120-4	1989	In contrast, lymphokine-mediated agglutination involves interactions between the MAggF cell-binding domain and integrin FN receptors recognizing the Arg-Gly-Asp sequence.	Arginine	149-152	interleukin 2	Homo sapiens	13-23
2534576-2	1989	This protein was bound strongly to arginine column and thus could be separated from fibronectin (FN).	Arginine	35-43	fibronectin 1	Homo sapiens	97-99
2684712-2	1989	GH-provocative tests with intravenous infusion of arginine revealed that urinary GH levels are closely correlated with the integrated concentrations of serum GH (r = .931, n = 14, P less than .001).	Arginine	50-58	growth hormone 1	Homo sapiens	0-2
2684712-2	1989	GH-provocative tests with intravenous infusion of arginine revealed that urinary GH levels are closely correlated with the integrated concentrations of serum GH (r = .931, n = 14, P less than .001).	Arginine	50-58	growth hormone 1	Homo sapiens	81-83
2684712-2	1989	GH-provocative tests with intravenous infusion of arginine revealed that urinary GH levels are closely correlated with the integrated concentrations of serum GH (r = .931, n = 14, P less than .001).	Arginine	50-58	growth hormone 1	Homo sapiens	81-83
2509458-7	1989	It has been shown that limited proteolysis/autolysis of the B-chain of alpha-thrombin in the area around Arg-B73 (in beta T/beta- and gamma T/gamma-thrombin), but not that around Lys-B154 (in gamma T/gamma-thrombin), diminishes specific interactions with fibrinogen (Hofsteenge, J., Braun, P. J., and Stone , S. R. (1988) Biochemistry 27, 2144-2151).	Arginine	105-108	coagulation factor II, thrombin	Homo sapiens	77-85
2509627-5	1989	In contrast, HC L-arg metabolism resulted in significantly greater production of NO2-/NO3- than citrulline.	Arginine	16-21	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
2697200-1	1989	Our previous study demonstrated increased levels of C5a des Arg and increased numbers of neutrophils in bronchoalveolar lavage (BAL) fluids of patients acutely ill with hypersensitivity pneumonitis (HP), suggesting that complement fragments activated by immune complexes (IC) play a role in the early stage of disease.	Arginine	60-63	complement C5a receptor 1	Homo sapiens	52-55
2509263-7	1989	Peptides with the sequence arg-gly-asp-ser or gly-arg-gly-asp-ser, which inhibit adhesive interactions mediated by the integrin-binding domain of fibronectin, had no effect on conveyance or accumulation of heparin-coated beads, but the peptide with the sequence gly-arg-gly, a repeated motif in the amino-terminal heparin-binding domain was completely inhibitory.	Arginine	27-30	fibronectin 1	Homo sapiens	146-157
2480947-6	1989	A 9.6-fold increase in permeability resulting from thrombin [0.15 U/ml (1 nM)] treatment was inhibited by pretreating the monolayers with dibutyryl cAMP-IBMX, 8-bromo cAMP-IBMX, dibutyryl cAMP-theophylline, dibutyryl cAMP, IBMX, iloprost, or D-Phe-Pro-Arg-CH2-alpha-thrombin (1 nM).	Arginine	251-255	coagulation factor II, thrombin	Homo sapiens	51-59
2617471-0	1989	Fibrinogen Baltimore IV: congenital dysfibrinogenemia with a gamma 275 (Arg----Cys) substitution.	Arginine	72-75	fibrinogen beta chain	Homo sapiens	0-10
2689869-0	1989	Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae.	Arginine	0-8	tryptophan synthase TRP5	Saccharomyces cerevisiae S288C	107-111
2689869-2	1989	Arginine restriction caused increased expression of HIS3 and TRP5, measured by the beta-galactosidase activity in strains carrying chromosomally integrated fusions of the promoter regions of each gene with the lacZ gene of Escherichia coli.	Arginine	0-8	tryptophan synthase TRP5	Saccharomyces cerevisiae S288C	61-65
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Arginine	193-196	epidermal growth factor receptor	Homo sapiens	39-51
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Arginine	193-196	epidermal growth factor receptor	Homo sapiens	121-133
2506948-1	1989	We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and arginine 1689 in the FVIII light chain in a naturally occurring dysfunctional FVIII variant, FVIII Okayama.	Arginine	116-124	coagulation factor II, thrombin	Homo sapiens	88-96
2506948-9	1989	We conclude that the pathogenesis of hemophilia A in this patient is probably due to an arginine to cysteine substitution at a thrombin cleavage site in the FVIII heavy chain.	Arginine	88-96	coagulation factor II, thrombin	Homo sapiens	127-135
2506948-0	1989	An arginine to cysteine amino acid substitution at a critical thrombin cleavage site in a dysfunctional factor VIII molecule.	Arginine	3-11	coagulation factor II, thrombin	Homo sapiens	62-70
2688759-12	1989	In particular, the construction of point and deletion mutants of vWF, employing vWF cDNA, and subsequent expression in heterologous cells have demonstrated that proteolytic processing of pro-vWF, between arginine (Arg-763) and serine (Ser-764), to generate free propolypeptide and mature vWF is not required for multimerization.	Arginine	204-212	von Willebrand factor	Homo sapiens	65-68
2555724-0	1989	Cyclic GMP stimulation by vasopressin in LLC-PK1 kidney epithelial cells is L-arginine-dependent.	Arginine	76-86	vasopressin	Sus scrofa	26-37
2583091-4	1989	Comparison of amino acid sequences of various cytochrome P-450 families revealed a highly conserved arginine residue in the immediate vicinity of the phosphorylated serine residue which constitutes the kinase recognition sequence.	Arginine	100-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	46-62
2555724-2	1989	In the present study NG-monomethyl-L-arginine was used to assess the role of L-arginine for cyclic GMP stimulation by vasopressin in a kidney epithelial cell line (LLC-PK1).	Arginine	35-45	vasopressin	Sus scrofa	118-129
2608050-2	1989	Bovine preprogastrin comprises 104 amino acids and consists of a signal peptide, a 37 amino acid spacer-sequence, the gastrin-34 sequence followed by an amidation-site (Gly-Arg-Arg), and a C-terminal nonapeptide.	Arginine	173-176	gastrin	Bos taurus	13-20
2608050-2	1989	Bovine preprogastrin comprises 104 amino acids and consists of a signal peptide, a 37 amino acid spacer-sequence, the gastrin-34 sequence followed by an amidation-site (Gly-Arg-Arg), and a C-terminal nonapeptide.	Arginine	177-180	gastrin	Bos taurus	13-20
2693945-4	1989	In the example described, the S. cerevisiae ARG4 gene, placed between a set of FRTs and integrated into Pichia in a prior transformation, was deleted by FLP, thereby regenerating an arginine-requiring phenotype in the P. pastoris strain.	Arginine	182-190	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	44-48
2619844-4	1989	A pure and active thrombin is obtained from a plasma fraction after adsorption on benzamidine-Spherodex followed by an elution with non specific (sodium chloride gradient) or biospecific competitors (arginine methylester or benzamidine).	Arginine	200-208	coagulation factor II, thrombin	Homo sapiens	18-26
2678107-2	1989	We now find that activity also resides in (i) the C-terminal tridecapeptide of PF4 (P13S), (ii) an analog of this in which arginine replaces the lysine residues and in which the last two amino acids are absent, (iii) the C-terminal 18 amino acids of low-affinity platelet factor 4, which is very similar to P13S, and (iv) peptide fragments of P13S that contain only 5-9 amino acids.	Arginine	123-131	platelet factor 4	Mus musculus	79-82
2504287-0	1989	Stimulus-secretion coupling of arginine-induced insulin release.	Arginine	31-39	insulin	Homo sapiens	48-55
2504287-2	1989	L-Arginine and L-ornithine stimulate insulin release from pancreatic islets exposed to D-glucose.	Arginine	0-10	insulin	Homo sapiens	37-44
2527855-8	1989	Laminin-binding by the alpha beta 1 complex was independent of Arg-Gly-Asp or Tyr-Ile-Gly-Ser-Arg-like sequences, but required the presence of divalent cations.	Arginine	63-66	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-35
2527855-8	1989	Laminin-binding by the alpha beta 1 complex was independent of Arg-Gly-Asp or Tyr-Ile-Gly-Ser-Arg-like sequences, but required the presence of divalent cations.	Arginine	94-97	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-35
2673537-3	1989	Endothelial cells exclusively recognize an Arg-Gly-Asp-containing site near the C-terminus of the alpha chain (alpha residues 572-574) but fail to recognize the Arg-Gly-Asp sequence in the N-terminal region of the same chain (alpha residues 95-97).	Arginine	43-46	Fc gamma receptor and transporter	Homo sapiens	98-133
2555724-7	1989	These results suggest that, in kidney epithelial cells, vasopressin induces nitric oxide formation from L-arginine leading to activation of soluble guanylate cyclase.	Arginine	104-114	vasopressin	Sus scrofa	56-67
2613766-10	1989	Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors.	Arginine	67-70	fibrinogen beta chain	Homo sapiens	22-25
2527912-0	1989	Inflammatory properties of human C5a and C5a des Arg/ in mast cell-depleted human skin.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
2527912-1	1989	C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection.	Arginine	41-44	complement C5a receptor 1	Homo sapiens	0-3
2527912-1	1989	C5a and its degradation product, C5a des Arg, elicit immediate cutaneous inflammatory reactions after intradermal injection.	Arginine	41-44	complement C5a receptor 1	Homo sapiens	33-36
2527912-8	1989	These infiltrates were qualitatively and quantitatively identical to C5a or C5a des Arg-induced infiltrates in mast cell replete skin.	Arginine	84-87	complement C5a receptor 1	Homo sapiens	76-79
2527912-9	1989	This experimental approach in vivo has allowed the independent analysis of the anaphylactogenic and chemoattractant activities of human C5a and C5a des Arg in human skin, demonstrated the importance of dermal mast cells in these clinical responses, and shown that leukocytes can accumulate at these injection sites directly in response to these mediators.	Arginine	152-155	complement C5a receptor 1	Homo sapiens	144-147
2588959-3	1989	This congenital dysfibrinogenemia with an A alpha arginine (Arg) to histidine (His) substitution was tentatively designated as fibrinogen Sapporo.	Arginine	60-63	fibrinogen beta chain	Homo sapiens	19-29
2506441-7	1989	These studies suggest that arginine 42 may be a contact point for TGF-alpha-EGF receptor interaction.	Arginine	27-35	epidermal growth factor receptor	Homo sapiens	76-88
2666106-9	1989	Stimulation with arginine plus different glucose concentrations, and leucine plus glutamine partially counteracted the rIL-1 beta-induced reduction of insulin release.	Arginine	17-25	interleukin 1 beta	Rattus norvegicus	119-129
2590469-3	1989	The Mi-VIII-specific glycophorin A was found to exhibit an arginine----threonine exchange at position 49.	Arginine	59-67	glycophorin A (MNS blood group)	Homo sapiens	21-34
2670195-1	1989	The VLA-Integrins are members of a family of cell surface receptors that recognize Arg-Gly-Asp containing ligands and that allow cells to bind extracellular matrix molecules such as fibronectin, laminin, and collagens.	Arginine	83-86	fibronectin 1	Homo sapiens	182-193
2666106-9	1989	Stimulation with arginine plus different glucose concentrations, and leucine plus glutamine partially counteracted the rIL-1 beta-induced reduction of insulin release.	Arginine	17-25	insulin	Homo sapiens	151-158
2489081-4	1989	The residues Arg 151 and Asn 232 of ABP from bidentate hydrogen bonds with both L-arabinose and D-galactose, but not with D-fucose or D-glucose.	Arginine	13-16	sex hormone binding globulin	Homo sapiens	36-39
2754274-9	1989	Adherence could be detected with C5 concentrations less than 200 ng/ml, which correspond to a C5a/C5a des arg concentration of 10(-8)-10(-9) molar.	Arginine	106-109	complement C5a receptor 1	Homo sapiens	98-101
2662695-10	1989	Net increase in acute insulin response after iv glucose and after iv arginine was significantly correlated to the net increase in erythrocyte magnesium content after dietary magnesium supplementation.	Arginine	69-77	insulin	Homo sapiens	22-29
2738072-9	1989	Affinity chromatography of various fibrinogen derivatives on a fibrin-Celite column showed that only part of the bound fragment DD was displaced by arginine, whereas fragments D1 and E1 were completely eluted under the same conditions.	Arginine	148-156	fibrinogen beta chain	Homo sapiens	35-45
2752109-0	1989	Molecular defects of factor IX Chicago-2 (Arg 145----His) and prothrombin Madrid (Arg 271----cys): arginine mutations that preclude zymogen activation.	Arginine	99-107	coagulation factor II, thrombin	Homo sapiens	62-73
2665515-5	1989	On the other hand, 10-40 mM K+ or 20 mM L-arginine induced a rapid monophasic insulin output.	Arginine	40-50	insulin	Gallus gallus	78-85
2817814-3	1989	Significant decreases in basal and arginine-stimulated serum growth hormone and serum IGF-I were noted.	Arginine	35-43	growth hormone 1	Homo sapiens	61-75
2817814-3	1989	Significant decreases in basal and arginine-stimulated serum growth hormone and serum IGF-I were noted.	Arginine	35-43	insulin like growth factor 1	Homo sapiens	86-91
2752109-5	1989	Prothrombin Madrid is cleaved abnormally by factor Xa, yielding a pattern consistent with the failure to cleave the sessile bond between Arg 271 and Thr 272.	Arginine	137-140	coagulation factor II, thrombin	Homo sapiens	0-11
2752109-9	1989	These mutations, each occurring at arginines, are identical to those in factor IX Chapel Hill and prothrombin Barcelona.	Arginine	35-44	coagulation factor II, thrombin	Homo sapiens	98-109
2549156-4	1989	A high variability was found both in the 24-h GH secretion expressed as area under the curve above the baseline (0-1588 mU/l x 24 h) and the maximal GH response to GHRH (5-296 mU/l), as well as after an arginine-insulin tolerance test (4-59 mU/l).	Arginine	203-211	growth hormone 1	Homo sapiens	46-48
2472350-0	1989	Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: the polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels.	Arginine	51-59	apolipoprotein B	Homo sapiens	0-16
2545728-0	1989	Von Willebrand factor promotes endothelial cell adhesion via an Arg-Gly-Asp-dependent mechanism.	Arginine	64-67	von Willebrand factor	Homo sapiens	0-21
2545728-13	1989	We found that the antibody that recognizes the residues 1,744-1,746, containing the Arg-Gly-Asp sequence, completely inhibit EC adhesion to vWF whereas a second antibody recognizing the adjacent residues 1,740-1,742 (Arg-Gly-Asp-free) is inactive.	Arginine	84-87	von Willebrand factor	Homo sapiens	140-143
2545728-15	1989	This defines the molecular domain on vWF that is specifically recognized by ECs and reaffirms the direct role of the Arg-Gly-Asp sequence as the integrin receptor recognition site also in the vWF molecule.	Arginine	117-120	von Willebrand factor	Homo sapiens	37-40
2545728-15	1989	This defines the molecular domain on vWF that is specifically recognized by ECs and reaffirms the direct role of the Arg-Gly-Asp sequence as the integrin receptor recognition site also in the vWF molecule.	Arginine	117-120	von Willebrand factor	Homo sapiens	192-195
2549156-4	1989	A high variability was found both in the 24-h GH secretion expressed as area under the curve above the baseline (0-1588 mU/l x 24 h) and the maximal GH response to GHRH (5-296 mU/l), as well as after an arginine-insulin tolerance test (4-59 mU/l).	Arginine	203-211	growth hormone releasing hormone	Homo sapiens	164-168
2542324-9	1989	A transition (C----T) was found in exon 6 on an allele, which resulted in an Arg to Trp (CGG----TGG) substitution at the 128th residue of AK1.	Arginine	77-80	adenylate kinase 1	Homo sapiens	138-141
2792459-0	1989	[Growth hormone response to arginine administration in diabetics--with special reference to the multiple regression analysis in association with diabetic retinopathy].	Arginine	28-36	growth hormone 1	Homo sapiens	1-15
2542324-10	1989	Since chicken AK1 is highly homologous to human AK1 with respect to the amino acid sequence, we introduced an Arg to Trp substitution to chicken AK1 at the same position by oligodeoxynucleotide-directed mutagenesis.	Arginine	110-113	adenylate kinase 1	Homo sapiens	48-51
2659219-1	1989	Arginine is used in supra-physiological concentrations as an insulin secretagogue, in both in vitro and in vivo studies.	Arginine	0-8	insulin	Homo sapiens	61-68
2656711-3	1989	Canavanine replacement for arginine causes a total loss of detectable antibacterial activity for diptericin B and diptericin C, whereas diptericin A and peak V protein are severely inhibited.	Arginine	27-35	Diptericin B	Drosophila melanogaster	97-109
2735907-11	1989	Like three other members of the family, FL-NCA-3 contains the Arg-Gly-Asp sequence in a position in the N-domain corresponding to complementarity determining region 3 of immunoglobulin.	Arginine	62-65	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	40-48
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	118-121	fibrinogen beta chain	Homo sapiens	81-91
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	118-121	Fc gamma receptor and transporter	Homo sapiens	141-152
2499363-7	1989	This is consistent with the demonstration in the patient"s leucocyte DNA of a C to T transition in codon 1,689 converting Arg to Cys at the light chain thrombin cleavage site as previously described by J. Gitschier et al (Blood 72:1022, 1988).	Arginine	122-125	coagulation factor II, thrombin	Homo sapiens	152-160
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Arginine	191-199	coagulation factor II, thrombin	Homo sapiens	136-144
2542089-9	1989	Labeling the transfected cells with [3H]Arg, followed by immunoprecipitation and SDS-PAGE showed the synthesis of a major peak of POMC, 33 kDa.	Arginine	40-43	proopiomelanocortin	Homo sapiens	130-134
2498882-5	1989	As these data indicate a loss of factor VIII cleavage by thrombin at arginine-372, the genetic defect was determined by polymerase-chain-reaction amplification of exon 8 of the factor VIII gene and direct sequencing of the amplified product.	Arginine	69-77	coagulation factor II, thrombin	Homo sapiens	57-65
2615098-1	1989	A previous study demonstrated increased levels of C5a des Arg and increased numbers of polymorphonuclear cells (PMNs) in bronchoalveolar lavage (BAL) fluids of acutely ill patients with summer type hypersensitivity pneumonitis (HP), suggesting the role of immune complexes (IC) in the early stage of HP.	Arginine	58-61	complement C5a receptor 1	Homo sapiens	50-53
2469496-8	1989	This antiserum also recognized the EC membrane protein complex eluted from the FN affinity column by an arg-gly-asp (RGD) peptide.	Arginine	104-107	fibronectin 1	Homo sapiens	79-81
2495172-0	1989	Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline.	Arginine	123-133	interferon gamma	Mus musculus	30-46
2495172-7	1989	The L-arginine-dependent pathway was involved in EMT6 cytostasis mediated by IFN-gamma + lipopolysaccharide because cytostasis expression required L-arginine and was inhibited by NG-monomethyl-L-arginine.	Arginine	4-14	interferon gamma	Mus musculus	77-86
2742826-4	1989	While resonances from residues Ala(1)-Glu(5) were little affected, binding of fibrinopeptide A to thrombin caused significant line broadening of NH and side-chain proton resonances within residues Asp(7)-Arg(16).	Arginine	204-207	coagulation factor II, thrombin	Homo sapiens	98-106
2495172-7	1989	The L-arginine-dependent pathway was involved in EMT6 cytostasis mediated by IFN-gamma + lipopolysaccharide because cytostasis expression required L-arginine and was inhibited by NG-monomethyl-L-arginine.	Arginine	147-157	interferon gamma	Mus musculus	77-86
2712830-1	1989	Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins.	Arginine	128-131	fibronectin 1	Homo sapiens	0-11
2742826-2	1989	At pH 5.3 and 25 degrees C, the Arg(16)-Gly(17) peptide bonds of both peptides F10 and F13 were cleaved instantaneously in the presence of 0.6 mM thrombin, whereas the cleavage of the Arg(19)-Val(20) peptide bonds in peptides F12, F13, and F14 took over 1 h for completion.	Arginine	32-35	coagulation factor II, thrombin	Homo sapiens	146-154
2742826-2	1989	At pH 5.3 and 25 degrees C, the Arg(16)-Gly(17) peptide bonds of both peptides F10 and F13 were cleaved instantaneously in the presence of 0.6 mM thrombin, whereas the cleavage of the Arg(19)-Val(20) peptide bonds in peptides F12, F13, and F14 took over 1 h for completion.	Arginine	184-187	coagulation factor II, thrombin	Homo sapiens	146-154
2742826-5	1989	There is a chain reversal within residues Asp(7)-Arg(16) such that Phe(8) is brought close to the Arg(16)-Gly(17) peptide bond in the thrombin-peptide complex, as indicated by transferred NOEs between the aromatic ring protons of Phe(8) and the C alpha H protons of Gly(14) and the C gamma H protons of Val(15).	Arginine	49-52	coagulation factor II, thrombin	Homo sapiens	134-142
2742826-5	1989	There is a chain reversal within residues Asp(7)-Arg(16) such that Phe(8) is brought close to the Arg(16)-Gly(17) peptide bond in the thrombin-peptide complex, as indicated by transferred NOEs between the aromatic ring protons of Phe(8) and the C alpha H protons of Gly(14) and the C gamma H protons of Val(15).	Arginine	98-101	coagulation factor II, thrombin	Homo sapiens	134-142
2742826-7	1989	Peptides with Arg(16) replaced by Gly and Leu, respectively, i.e., F14 and F15, were also found to bind to thrombin but with a different conformation, as indicated by the absence of the long-range NOEs observed with fibrinopeptide A. Residues Asp(7)-Arg(16) constitute an essential structural element in the interaction of thrombin with fibrinogen.	Arginine	14-17	coagulation factor II, thrombin	Homo sapiens	107-115
2742827-2	1989	At pH 5.3 and 25 degrees C, the Arg(16)-Gly(17) peptide bonds in both F6 and F8 were cleaved instantaneously in the presence of 0.5 mM thrombin, producing truncated peptides tF6 and tF8 and other peptide fragments.	Arginine	32-35	coagulation factor II, thrombin	Homo sapiens	135-143
2742828-4	1989	Binding of thrombin to peptides F16 and F17, and hence to tF16 and tF17 as a result of the cleavage of the Arg(16)-Gly(17) peptide bond, broadens the proton resonances of residues Asp(7) to Arg(16), suggesting that thrombin interacts specifically with this sequence of residues.	Arginine	107-110	coagulation factor II, thrombin	Homo sapiens	11-19
2473617-0	1989	The cardiac and renal effects of the complement fragment C5a des Arg are partly mediated by the release of histamine and arachidonic acid metabolites.	Arginine	65-68	complement C5a receptor 1	Homo sapiens	57-60
2742828-4	1989	Binding of thrombin to peptides F16 and F17, and hence to tF16 and tF17 as a result of the cleavage of the Arg(16)-Gly(17) peptide bond, broadens the proton resonances of residues Asp(7) to Arg(16), suggesting that thrombin interacts specifically with this sequence of residues.	Arginine	107-110	coagulation factor II, thrombin	Homo sapiens	215-223
2473617-1	1989	This report suggests that the release of various inflammatory mediators such as histamine, LTC4, D4 and E4, and TXA2 measured as the stable metabolite TXB2 are partly responsible for the various cardiac and renal effects of the complement fragment C5a des Arg anaphylatoxin, in addition to its direct vasoconstrictor activity.	Arginine	256-259	complement C5a receptor 1	Homo sapiens	248-251
2742828-10	1989	This altered geometry presumably affects the positioning of the Arg(16)-Gly(17) bond in the active site of thrombin.	Arginine	64-67	coagulation factor II, thrombin	Homo sapiens	107-115
2760009-2	1989	One of these alleles encodes an apoE isoprotein having cysteine, arginine, and cysteine at positions 112, 145, and 158 of mature apoE isoproteins, respectively, indicating an epsilon apoE2 allele.	Arginine	65-73	apolipoprotein E	Homo sapiens	32-36
2539165-5	1989	In serum, however, the C-terminal Arg was removed from bradykinin about five times faster than was accounted for by the activity of carboxypeptidase N. The primary substrate of ACE in serum, therefore, was des-Arg9-bradykinin and not bradykinin.	Arginine	34-37	kininogen 1	Homo sapiens	215-225
2539165-3	1989	Angiotensin-converting enzyme was an effective kininase in mixtures with carboxypeptidase N at physiologic concentration and digested bradykinin to the dipeptides Phe- Arg and Ser-Pro plus the pentapeptide Arg-Pro-Pro-Gly-Phe.	Arginine	168-171	angiotensin I converting enzyme	Homo sapiens	0-29
2539165-8	1989	Our studies indicate that the final products of bradykinin degradation were the tripeptide Arg-Pro-Pro, one mole each of Ser, Pro, Gly, and Arg, and two moles of phenylalanine.	Arginine	91-94	kininogen 1	Homo sapiens	48-58
2539165-3	1989	Angiotensin-converting enzyme was an effective kininase in mixtures with carboxypeptidase N at physiologic concentration and digested bradykinin to the dipeptides Phe- Arg and Ser-Pro plus the pentapeptide Arg-Pro-Pro-Gly-Phe.	Arginine	168-171	kininogen 1	Homo sapiens	134-144
2539165-4	1989	Carboxypeptidase N slowly removed the C-terminal Arg from bradykinin to yield des-Arg9-bradykinin (DBK); the latter was digested by ACE to yield the aforementioned pentapeptide and the tripeptide Ser-Pro-Phe.	Arginine	49-52	kininogen 1	Homo sapiens	58-68
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Arginine	97-100	progastricsin (pepsinogen C)	Mus musculus	134-137
2539165-4	1989	Carboxypeptidase N slowly removed the C-terminal Arg from bradykinin to yield des-Arg9-bradykinin (DBK); the latter was digested by ACE to yield the aforementioned pentapeptide and the tripeptide Ser-Pro-Phe.	Arginine	49-52	kininogen 1	Homo sapiens	87-97
2539165-5	1989	In serum, however, the C-terminal Arg was removed from bradykinin about five times faster than was accounted for by the activity of carboxypeptidase N. The primary substrate of ACE in serum, therefore, was des-Arg9-bradykinin and not bradykinin.	Arginine	34-37	kininogen 1	Homo sapiens	55-65
2539165-5	1989	In serum, however, the C-terminal Arg was removed from bradykinin about five times faster than was accounted for by the activity of carboxypeptidase N. The primary substrate of ACE in serum, therefore, was des-Arg9-bradykinin and not bradykinin.	Arginine	34-37	angiotensin I converting enzyme	Homo sapiens	177-180
2539165-5	1989	In serum, however, the C-terminal Arg was removed from bradykinin about five times faster than was accounted for by the activity of carboxypeptidase N. The primary substrate of ACE in serum, therefore, was des-Arg9-bradykinin and not bradykinin.	Arginine	34-37	kininogen 1	Homo sapiens	215-225
2764968-3	1989	The canine sequence encodes a preprogastrin of 104 amino acids which consists of a signal peptide, a 37-amino acid prosegment, and a 34-amino acid gastrin sequence, followed by a glycine (the amide donor), and flanked by pairs of arginine residues.	Arginine	230-238	gastrin	Canis lupus familiaris	36-43
2710782-4	1989	By analysis of the human alpha-thrombin:hirudin inhibition reaction in steady-state conditions it was shown that the dissociation constants for HV2(Lys-47) and HV2(Arg-47) were 5- to 14-fold lower than for unmodified HV2, whereas mutation of Lys-35 did not significantly alter the inhibition kinetics.	Arginine	164-167	coagulation factor II, thrombin	Homo sapiens	31-39
2466458-4	1989	Among them, KW2228, in which Thr-1, Leu-3, Gly-4, Pro-5 and Cys-17 were respectively substituted with Ala, Thr, Tyr, Arg and Ser, showed more potent granulopoietic activity than that of intact hG-CSF both in vitro and in vivo.	Arginine	117-120	thyroid hormone receptor beta	Homo sapiens	29-34
2536743-2	1989	The arginine-specific reagents phenylglyoxal, 2,3-butanedione, and 1,2-cyclohexanedione all irreversibly inhibit the enzyme with second-order rate constants of 3.42 M-1 min-1, 3.13 M-1 min-1 and 0.313 M-1 min-1, respectively.	Arginine	4-12	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
2493268-2	1989	The pancreatic stone protein isolated from human calculi (PSP) derives from the immunoreactive protein forms detected in human pancreatic juice (PSP S2-5) through the tryptic cleavage of the Arg-11-Ile-12 bond.	Arginine	191-194	regenerating family member 1 alpha	Homo sapiens	58-61
2493268-2	1989	The pancreatic stone protein isolated from human calculi (PSP) derives from the immunoreactive protein forms detected in human pancreatic juice (PSP S2-5) through the tryptic cleavage of the Arg-11-Ile-12 bond.	Arginine	191-194	regenerating family member 1 alpha	Homo sapiens	145-148
2537662-2	1989	The derivatization of catalase resulted in coupling the long-chain fatty acyl residues to lysine, histidine and arginine, while other amino acids remained essentially unaffected.	Arginine	112-120	catalase	Rattus norvegicus	22-30
2536743-2	1989	The arginine-specific reagents phenylglyoxal, 2,3-butanedione, and 1,2-cyclohexanedione all irreversibly inhibit the enzyme with second-order rate constants of 3.42 M-1 min-1, 3.13 M-1 min-1 and 0.313 M-1 min-1, respectively.	Arginine	4-12	CD59 molecule (CD59 blood group)	Homo sapiens	185-190
2470136-7	1989	MoAb 2A5E3 was able to bind 125I-labelled human C5a des Arg.	Arginine	56-59	complement C5a receptor 1	Homo sapiens	48-51
2536743-2	1989	The arginine-specific reagents phenylglyoxal, 2,3-butanedione, and 1,2-cyclohexanedione all irreversibly inhibit the enzyme with second-order rate constants of 3.42 M-1 min-1, 3.13 M-1 min-1 and 0.313 M-1 min-1, respectively.	Arginine	4-12	CD59 molecule (CD59 blood group)	Homo sapiens	185-190
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Arginine	113-121	superoxide dismutase 1	Homo sapiens	31-57
2470136-9	1989	MoAb 5B2C5 and 2B1A2, which are directed to different antigenic binding sites on C5a, may be applied in a sandwich ELISA for the detection and quantification of C5a des Arg in rabbit serum or plasma.	Arginine	169-172	complement C5a receptor 1	Homo sapiens	81-84
2470136-9	1989	MoAb 5B2C5 and 2B1A2, which are directed to different antigenic binding sites on C5a, may be applied in a sandwich ELISA for the detection and quantification of C5a des Arg in rabbit serum or plasma.	Arginine	169-172	complement C5a receptor 1	Homo sapiens	161-164
2470136-11	1989	Complement activation is demonstrated by measuring the increased generation of C5a des Arg in rabbit plasma or serum activated with LPS, zymosan, antigen-antibody complexes, or cobra venom factor.	Arginine	87-90	complement C5a receptor 1	Homo sapiens	79-82
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Arginine	154-162	superoxide dismutase 1	Homo sapiens	116-124
2492791-1	1989	Site-specific mutants of human Cu,Zn superoxide dismutase (Cu,ZnSOD) have been prepared in which the active-site arginine at position 143 (i.e., SODR143) has been replaced by either lysine (SODK143) or isoleucine (SODI143).	Arginine	113-121	superoxide dismutase 1	Homo sapiens	59-67
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Arginine	39-47	superoxide dismutase 1	Homo sapiens	116-124
2537118-0	1989	Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity.	Arginine	75-78	fibrinogen beta chain	Homo sapiens	0-10
2536701-6	1989	Residues 49, 50, and 51 in IGF I are Phe-Arg-Ser and are strictly conserved in IGF II.	Arginine	41-44	insulin like growth factor 1	Homo sapiens	27-32
2493374-1	1989	The role of arginine 115 in human lysozyme revealed by site-directed mutagenesis.	Arginine	12-20	lysozyme	Homo sapiens	34-42
2493374-2	1989	Arginine 115 in the subsite F of human lysozyme (peptidoglycan N-acetylmuramoylhydrolase, EC 3.2.1.17) was replaced with lysine, histidine, glutamine or glutamine acid by site-directed mutagenesis.	Arginine	0-8	lysozyme	Homo sapiens	39-47
2536701-7	1989	Residues 55 and 56 of IGF I and the corresponding residues in IGF II are Arg-Arg and Ala-Leu, respectively.	Arginine	73-76	insulin like growth factor 1	Homo sapiens	22-27
2924902-1	1989	We have identified a synthetic peptide derived from the B2-chain of mouse laminin, Arg-Asn-Ile-Ala-Glu-Ile-Ile-Lys-Asp-Ile (p20), which stimulates the neurite outgrowth-promoting activity of the native molecule.	Arginine	83-86	demilune cell and parotid protein 1	Mus musculus	124-127
2536701-7	1989	Residues 55 and 56 of IGF I and the corresponding residues in IGF II are Arg-Arg and Ala-Leu, respectively.	Arginine	77-80	insulin like growth factor 1	Homo sapiens	22-27
2913054-8	1989	Induction studies in cell lines that similarly express only the AII isozyme indicated that its activity could be enhanced severalfold by exposure to elevated arginine levels.	Arginine	158-166	NLR family pyrin domain containing 3	Homo sapiens	64-67
2521774-2	1989	The authors have prepared a membrane fraction of isolated human glomeruli, from which two proteins (apparent molecular weights 120 kd and 140 kd) bound to a fibronectin-column, and were selectively released by the synthetic peptide Arg-Gly-Asp-Ser.	Arginine	232-235	fibronectin 1	Homo sapiens	157-168
2909523-10	1989	In human PL (hPL), which has low growth-promoting activity, 35 of these 37 residues are conserved, while the other 2 residues in the GD1 domain (Arg-16 and Leu-20) are replaced by Gln and Ala, respectively.	Arginine	145-148	chorionic somatomammotropin hormone 2	Homo sapiens	9-11
2493055-1	1989	C5a and C5a des Arg are potent complement-derived mediators that bind receptors on peripheral blood leukocytes and tissue-specific cellular elements to elicit and amplify inflammatory and immunomodulatory reactions.	Arginine	16-19	complement C5a receptor 1	Homo sapiens	8-11
2493055-3	1989	Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities.	Arginine	185-188	complement C5a receptor 1	Homo sapiens	16-19
2493055-3	1989	Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities.	Arginine	185-188	complement C5a receptor 1	Homo sapiens	106-109
2493055-3	1989	Fluoresceinated C5a produced neutrophil myeloperoxidase release and chemotaxis and also bound rabbit anti-C5a antibody much like native anaphylatoxin; likewise, fluoresceinated C5a des Arg demonstrated retention of biologic and antigenic activities.	Arginine	185-188	complement C5a receptor 1	Homo sapiens	106-109
2493055-4	1989	Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes.	Arginine	44-47	complement C5a receptor 1	Homo sapiens	36-39
2493055-4	1989	Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes.	Arginine	44-47	complement C5a receptor 1	Homo sapiens	36-39
2493055-4	1989	Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes.	Arginine	200-203	complement C5a receptor 1	Homo sapiens	28-31
2493055-4	1989	Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes.	Arginine	200-203	complement C5a receptor 1	Homo sapiens	36-39
2493055-4	1989	Both fluorescein-conjugated C5a and C5a des Arg bound to monocytes and neutrophils in a concentration-dependent, saturable, and homogeneous manner, but 10- to 15-fold higher concentrations of C5a des Arg were required to attain saturable binding of these leukocytes.	Arginine	200-203	complement C5a receptor 1	Homo sapiens	36-39
2493055-8	1989	A representative half-maximal binding of fluorescein-conjugated C5a (C5a des Arg) binding to monocytes and neutrophils was 1.2 nM (30 nM) and 2.6 nM (68 nM), respectively.	Arginine	77-80	complement C5a receptor 1	Homo sapiens	64-67
2493055-8	1989	A representative half-maximal binding of fluorescein-conjugated C5a (C5a des Arg) binding to monocytes and neutrophils was 1.2 nM (30 nM) and 2.6 nM (68 nM), respectively.	Arginine	77-80	complement C5a receptor 1	Homo sapiens	69-72
2521482-3	1989	The fibronectin receptor bound only to fibronectin of the various Arg-Gly-Asp (RGD)-containing proteins tested.	Arginine	66-69	fibronectin 1	Homo sapiens	4-15
2642901-1	1989	Selective cleavage by protease Arg C. Treatment of the dihydrolipoyl transacetylase-protein X-kinase subcomplex (E2-X-KcKb) with protease Arg C selectively converted protein X into an inner domain fragment (Mr approximately equal to 35,000) and an outer (lipoyl-bearing) domain fragment (Mr approximately equal to 15,500).	Arginine	31-34	regenerating family member 1 alpha	Homo sapiens	84-93
2642901-1	1989	Selective cleavage by protease Arg C. Treatment of the dihydrolipoyl transacetylase-protein X-kinase subcomplex (E2-X-KcKb) with protease Arg C selectively converted protein X into an inner domain fragment (Mr approximately equal to 35,000) and an outer (lipoyl-bearing) domain fragment (Mr approximately equal to 15,500).	Arginine	31-34	regenerating family member 1 alpha	Homo sapiens	166-175
2642907-6	1989	In rat liver, aspartyl-tRNA synthetase occurs in two distinct forms: a dimeric enzyme and a component of a multienzyme complex comprising the nine aminoacyl-tRNA synthetases specific for arginine, aspartic acid, glutamic acid, glutamine, isoleucine, leucine, lysine, methionine, and proline.	Arginine	187-195	aspartyl-tRNA synthetase 1	Rattus norvegicus	14-38
2680252-2	1989	The pancreatic stone protein (PSP, Mr 15,000) which has been discovered in human calculi derives from the native glycosylated forms of the protein (Mrs 17,500-22,000) which are present in human pancreatic juice through tryptic cleavage of the Arg 11-Ile 12 bond.	Arginine	243-246	regenerating family member 1 alpha	Homo sapiens	4-28
2912421-6	1989	In this study, we describe a method in which a pair of 19-mer synthetic oligonucleotide probes were used to distinguish between DNA coding for arginine or cysteine at position 158 in apo E.	Arginine	143-151	apolipoprotein E	Homo sapiens	183-188
2469549-8	1989	By varying doses, a synergetic action of CCK plus amino acid on the secretion of pancreatic digestive enzymes was observed at 0.5 mM for valine and 5 mM for arginine.	Arginine	157-165	cholecystokinin	Homo sapiens	41-44
2680252-2	1989	The pancreatic stone protein (PSP, Mr 15,000) which has been discovered in human calculi derives from the native glycosylated forms of the protein (Mrs 17,500-22,000) which are present in human pancreatic juice through tryptic cleavage of the Arg 11-Ile 12 bond.	Arginine	243-246	regenerating family member 1 alpha	Homo sapiens	30-33
2806936-4	1989	To modify this interaction, we placed a peptide containing the arginine-glycine-aspartic acid sequence that competes for the cellular binding site of fibronectin onto the collagen gels.	Arginine	63-71	fibronectin 1	Homo sapiens	150-161
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	27-30	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	143-146	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	143-146	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	143-146	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	143-146	angiotensinogen	Homo sapiens	35-38
2680365-8	1989	The results showed an AGG (Arg) to AGT (Ser) point mutation, resulting in the change of the interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	143-146	angiotensinogen	Homo sapiens	35-38
2547596-1	1989	Corticostatins (CS"s) are a family of low molecular weight peptides, rich in arginine and cysteine with the ability to inhibit ACTH stimulated adrenocortical steroidogenesis.	Arginine	77-85	proopiomelanocortin	Homo sapiens	127-131
2555283-15	1989	The mechanisms by which arginine- and histidine-rich polyelectrolytes activate the respiratory burst in neutrophils might involve interaction with G-proteins, the activation of arachidonic acid metabolism and phospholipase A2, or the interaction with myeloperoxidase.	Arginine	24-32	phospholipase A2 group IB	Homo sapiens	209-225
2555283-15	1989	The mechanisms by which arginine- and histidine-rich polyelectrolytes activate the respiratory burst in neutrophils might involve interaction with G-proteins, the activation of arachidonic acid metabolism and phospholipase A2, or the interaction with myeloperoxidase.	Arginine	24-32	myeloperoxidase	Homo sapiens	251-266
2472923-5	1989	Some of them are specific only to C5a-des-Arg but not to C5a or C5.	Arginine	42-45	complement C5a receptor 1	Homo sapiens	34-37
2472923-7	1989	The neoepitopes for these MoAbs were analyzed by their reactivities to synthetic peptide derivatives of human and porcine C5a, and the structural changes of C5a were suggested to occur after the removal of the carboxyl terminal arginine residue.	Arginine	228-236	complement C5a receptor 1	Homo sapiens	157-160
2547672-2	1989	Myeloperoxidase is inhibited by various diketones that are recognized arginine reagents.	Arginine	70-78	myeloperoxidase	Homo sapiens	0-15
2696721-1	1989	A prepubertal boy with apparent growth hormone (GH)-dependent growth failure displayed a marked increase in growth velocity, normal GH responses to arginine/insulin infusion and a fourfold increase in spontaneous 24-hour GH secretion following the onset of normal puberty.	Arginine	148-156	growth hormone 1	Homo sapiens	32-46
2496037-7	1989	This region is identical between Lol p II and III, except for an Arg-Lys substitution, and could account, in part, for the DR3 association with responsiveness to both molecules.	Arginine	65-68	TNF receptor superfamily member 25	Homo sapiens	123-126
2634610-6	1989	Plasma insulin showed a poor response to arginine infusion.	Arginine	41-49	insulin	Homo sapiens	7-14
2461903-4	1989	Two amino acid residues of HLA-A29.1, gln-144 and arg-151, were found in all 24 HLA-B and HLA-C alleles examined but were present in only one of 15 HLA-A alleles for which sequence data are available.	Arginine	50-53	major histocompatibility complex, class I, A	Homo sapiens	27-32
2738036-5	1989	Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of one of the CNBr fragments derived from fibrinogen Nagoya indicated that Gln-329 in the gamma-chain had been replaced by Arg.	Arginine	208-211	fibrinogen beta chain	Homo sapiens	127-137
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Arginine	48-51	integrin subunit beta 2	Homo sapiens	11-15
2544772-6	1989	The endothelium dependent vasodilator peptides such as bradykinin contain L-arginine in their sequence.	Arginine	74-84	kininogen 1	Homo sapiens	55-65
2783323-5	1989	Similarly, LPS-free purified C3a, C5a, and C5a des Arg all showed no IL-1-inducing activities at concentrations up to 25 micrograms/ml.	Arginine	51-54	complement C5a receptor 1	Homo sapiens	43-46
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	fibronectin 1	Homo sapiens	148-159
3242619-10	1988	Together, these results indicate that Arg-382 is a critical residue in determining the specificity of thrombin toward fibrinogen.	Arginine	38-41	coagulation factor II, thrombin	Homo sapiens	102-110
2788339-6	1989	C3a des Arg levels did not differ significantly from the reference values, and C5a des Arg level has been within the normal range in all the patients.	Arginine	87-90	complement C5a receptor 1	Homo sapiens	79-82
3207421-2	1988	In this procedure, DNA is amplified by the polymerase chain reaction, and allele-specific oligonucleotide probes are used to detect the cysteine-arginine interchanges at residues 112 and 158 that distinguish the three common isoforms of apolipoprotein E.	Arginine	145-153	apolipoprotein E	Homo sapiens	237-253
2461939-2	1988	The amino acid sequence of BSP contains an Arg-Gly-Asp (RGD) sequence which confers to the protein cell binding properties (Oldberg, A., Franzen, A., and Heinegard, D. (1988) J. Biol.	Arginine	43-46	integrin-binding sialoprotein	Rattus norvegicus	27-30
2516316-7	1989	A second class of GTPase inhibiting mutations in alpha s occurs in the codon for an Arg residue whose covalent modification by cholera toxin also inhibits GTP hydrolysis by alpha s. This Arg residue is located in a domain of alpha s not represented in EF-Tu or p21ras.	Arginine	84-87	Tu translation elongation factor, mitochondrial	Homo sapiens	252-257
2516316-7	1989	A second class of GTPase inhibiting mutations in alpha s occurs in the codon for an Arg residue whose covalent modification by cholera toxin also inhibits GTP hydrolysis by alpha s. This Arg residue is located in a domain of alpha s not represented in EF-Tu or p21ras.	Arginine	187-190	Tu translation elongation factor, mitochondrial	Homo sapiens	252-257
3198635-6	1988	BSP contains an Arg-Gly-Asp sequence, which presumably is responsible for its cell binding properties (Oldberg, A., Franzen, A., Heinegard, D., Pierschbacher, M., and Ruoslahti, E. (1988) J. Biol.	Arginine	16-19	integrin-binding sialoprotein	Rattus norvegicus	0-3
3154642-0	1988	Lack of effect of nicardipine and diltiazem on glucose- and arginine-induced insulin release in obese subjects.	Arginine	60-68	insulin	Homo sapiens	77-84
3149585-5	1988	Here we describe the isolation and characterization of one such gene (xerA) and show it to be identical to the gene encoding the repressor of the arginine biosynthetic genes (argR).	Arginine	146-154	arginine repressor	Escherichia coli	175-179
3149585-6	1988	The argR protein binds to cer DNA both in vivo and in vitro in the presence of arginine.	Arginine	79-87	arginine repressor	Escherichia coli	4-8
3219291-6	1988	The mutation, involving the haemophiliac, his mother, his sister and her fetus, transforms a CGA codon that encodes for arginine in the catalytic domain of the protein into a UGA stop codon.	Arginine	120-128	chromogranin A	Homo sapiens	93-96
2903866-0	1988	Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.	Arginine	0-8	somatostatin	Rattus norvegicus	71-83
3073092-5	1988	Play in favor of this hypothesis the fact that the administration of PGE inhibits the insulin response to arginine in type-2 diabetics but not in normal subject and the fact that the administration of salicylates could improve the insulin response to glucose in some of these patients.	Arginine	106-114	insulin	Homo sapiens	86-93
3073905-0	1988	Repetitive stimulation of insulin secretion with arginine and glucose.	Arginine	49-57	insulin	Homo sapiens	26-33
3073905-1	1988	Glucose and arginine are both known to be potent insulin secretagogues and to potentiate each others insulin secretion.	Arginine	12-20	insulin	Homo sapiens	49-56
3073905-1	1988	Glucose and arginine are both known to be potent insulin secretagogues and to potentiate each others insulin secretion.	Arginine	12-20	insulin	Homo sapiens	101-108
3073905-2	1988	We investigated if repetitive infusion of arginine leads to comparable insulin secretion during fasting and if the additional infusion of glucose leads to a change in the pattern of the insulin secretion during repeated infusion of arginine.	Arginine	232-240	insulin	Homo sapiens	186-193
3073905-3	1988	Repeated continuous infusions of arginine (0.3 g/kg in 30 min) in six normals led to a lower second phase insulin secretion during the third infusion (p less than 0.05).	Arginine	33-41	insulin	Homo sapiens	106-113
3073905-7	1988	We conclude first, that concomitant hyperglycemia potentiates second phase insulin secretion and second, that prolonged fasting leads to an adaptation of the pancreas B-cell leading to diminished arginine-induced insulin secretion, which can be overcome by additional infusion of glucose.	Arginine	196-204	insulin	Homo sapiens	213-220
3073905-8	1988	This potentially confounding factor will have to be taken into account in planning future investigations of arginine-induced insulin secretion.	Arginine	108-116	insulin	Homo sapiens	125-132
2848742-8	1988	Attachment to and syncytia formation on fibronectin was blocked by the addition of the R-G-D-S-containing peptide, Gly-Arg-Gly-Asp-Ser-Pro.	Arginine	119-122	fibronectin 1	Homo sapiens	40-51
3147185-9	1988	Similarly impaired in class 3/3 persons was the glucose + arginine-stimulated insulin secretion (P less than 0.05).	Arginine	58-66	insulin	Homo sapiens	78-85
2903866-14	1988	We conclude that the stimulatory effects of Arg are mediated by suppression of endogenous somatostatin secretion.	Arginine	44-47	somatostatin	Rattus norvegicus	90-102
2464131-4	1988	Also unique to this new TGF beta is an insertion of two amino acids near the N-terminus of the processed peptide which would result in a 114 amino acid mature protein after cleavage from the precursor at a tetrabasic arg-arg-arg-arg site.	Arginine	217-220	transforming growth factor beta 1	Homo sapiens	24-32
3148007-4	1988	In particular we have identified the arginine residue at position 125 of human IFN-alpha 1 as a major mediator of the molecules antiviral activity on mouse cells.	Arginine	37-45	interferon alpha 1	Homo sapiens	79-90
2464131-4	1988	Also unique to this new TGF beta is an insertion of two amino acids near the N-terminus of the processed peptide which would result in a 114 amino acid mature protein after cleavage from the precursor at a tetrabasic arg-arg-arg-arg site.	Arginine	221-224	transforming growth factor beta 1	Homo sapiens	24-32
2464131-4	1988	Also unique to this new TGF beta is an insertion of two amino acids near the N-terminus of the processed peptide which would result in a 114 amino acid mature protein after cleavage from the precursor at a tetrabasic arg-arg-arg-arg site.	Arginine	221-224	transforming growth factor beta 1	Homo sapiens	24-32
2464131-4	1988	Also unique to this new TGF beta is an insertion of two amino acids near the N-terminus of the processed peptide which would result in a 114 amino acid mature protein after cleavage from the precursor at a tetrabasic arg-arg-arg-arg site.	Arginine	221-224	transforming growth factor beta 1	Homo sapiens	24-32
3177326-4	1988	Growth hormone release was evaluated by arginine and levodopa tests after the end of treatment.	Arginine	40-48	growth hormone 1	Homo sapiens	0-14
3183381-0	1988	Human C5a and C5a des Arg exhibit chemotactic activity for fibroblasts.	Arginine	22-25	complement C5a receptor 1	Homo sapiens	14-17
3183381-1	1988	C5a and C5a des Arg are chemotactic factors for inflammatory cells but it is not known whether these agents are chemoattractants for fibroblasts.	Arginine	16-19	complement C5a receptor 1	Homo sapiens	8-11
3183381-2	1988	Accordingly, C5a, purified from zymosan-activated human, and C5a des Arg, prepared by incubating C5a with immobilized porcine carboxypeptidase B, were studied for fibroblast chemotactic activity.	Arginine	69-72	complement C5a receptor 1	Homo sapiens	61-64
3183381-2	1988	Accordingly, C5a, purified from zymosan-activated human, and C5a des Arg, prepared by incubating C5a with immobilized porcine carboxypeptidase B, were studied for fibroblast chemotactic activity.	Arginine	69-72	complement C5a receptor 1	Homo sapiens	61-64
2460346-0	1988	Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets.	Arginine	6-9	fibronectin 1	Homo sapiens	57-68
3183381-5	1988	Cochemotaxin, which enhances the chemotactic activity of C5a des Arg for neutrophils, had no effect on C5a des Arg fibroblast chemotactic activity but appeared to increase the fibroblast chemotactic activity of C5a.	Arginine	65-68	complement C5a receptor 1	Homo sapiens	57-60
3183381-6	1988	These results indicate that the effects of C5a and C5a des Arg in vivo may extend to the recruitment of mesenchymal cells.	Arginine	59-62	complement C5a receptor 1	Homo sapiens	51-54
3183381-7	1988	Moreover, the findings represent another example of an activity retained by C5a after removal of its carboxyl terminal arginine.	Arginine	119-127	complement C5a receptor 1	Homo sapiens	76-79
3266214-0	1988	Site-specific mutagenesis of the human interleukin-1 beta gene: the role of arginine residue at the N-terminal region.	Arginine	76-84	interleukin 1 beta	Homo sapiens	39-57
3266214-3	1988	When we changed the arginine at the 4th position (Arg4) in IL-1 beta to other specific amino acids, there was a marked difference in the relative extent of biological and receptor binding activities among the mutants.	Arginine	20-28	interleukin 1 beta	Homo sapiens	59-68
3266214-5	1988	Our results demonstrate that the arginine residue at the 4th position in IL-1 beta is important, but not essential, for IL-1 beta to exhibit its biological and receptor binding activities, and the positive charge at this site plays a key role for IL-1 beta to exert the activities.	Arginine	33-41	interleukin 1 beta	Homo sapiens	73-82
2977643-4	1988	With increasing time of incubation with rat serum, proANF is sequentially cleaved at the C-terminus of a monobasic Pro-Arg dipeptide sequence to form ANF99-126, and then at the C-terminus of a dibasic Arg-Arg dipeptide sequence to yield ANF103-126.	Arginine	119-122	natriuretic peptide A	Homo sapiens	54-57
2977643-4	1988	With increasing time of incubation with rat serum, proANF is sequentially cleaved at the C-terminus of a monobasic Pro-Arg dipeptide sequence to form ANF99-126, and then at the C-terminus of a dibasic Arg-Arg dipeptide sequence to yield ANF103-126.	Arginine	201-204	natriuretic peptide A	Homo sapiens	54-57
3233203-4	1988	Group-specific modification of either arginine, lysine, or histidine residues of bindin results in a substantial inactivation of fucan binding activity.	Arginine	38-46	bindin	Strongylocentrotus purpuratus	81-87
3141449-1	1988	Plasma GH responses to human GHRH, arginine, L-dopa, and insulin-induced hypoglycemia were determined in seven myotonic dystrophy (MD) patients.	Arginine	35-43	growth hormone 1	Homo sapiens	7-9
3141449-5	1988	The plasma GH responses to a 30-min iv infusion of arginine (0.5 g/kg BW) and oral ingestion of L-dopa (0.5 g) were attenuated to a similar extent, whereas insulin-induced hypoglycemia caused a significant increase in plasma GH in all seven MD patients [mean peak, 17.4 +/- 4.1 (+/- SE) microgram/L].	Arginine	51-59	growth hormone 1	Homo sapiens	11-13
3141449-5	1988	The plasma GH responses to a 30-min iv infusion of arginine (0.5 g/kg BW) and oral ingestion of L-dopa (0.5 g) were attenuated to a similar extent, whereas insulin-induced hypoglycemia caused a significant increase in plasma GH in all seven MD patients [mean peak, 17.4 +/- 4.1 (+/- SE) microgram/L].	Arginine	51-59	insulin	Homo sapiens	156-163
3141449-5	1988	The plasma GH responses to a 30-min iv infusion of arginine (0.5 g/kg BW) and oral ingestion of L-dopa (0.5 g) were attenuated to a similar extent, whereas insulin-induced hypoglycemia caused a significant increase in plasma GH in all seven MD patients [mean peak, 17.4 +/- 4.1 (+/- SE) microgram/L].	Arginine	51-59	growth hormone 1	Homo sapiens	225-227
3141449-7	1988	These findings suggest that 1) the impaired GH release after GHRH, arginine, and L-dopa administration in MD patients is not due to somatotroph deficiency, since the GH response to hypoglycemia is well preserved; and 2) insulin-induced hypoglycemia may stimulate GH release at least in part via inhibition of somatostatin release.	Arginine	67-75	growth hormone 1	Homo sapiens	44-46
3241126-8	1988	Human apoB arginine-3,359 corresponds to a critical arginine (position 142) residue in the apoE LDL receptor binding domain.	Arginine	11-19	apolipoprotein B	Homo sapiens	6-10
2485226-9	1988	Moreover, they provide evidence that the Arg-Gly-Asp sequence is the only, or essential, GP IIb-IIIa binding site in the vWF molecule.	Arginine	41-44	LOW QUALITY PROTEIN: von Willebrand factor	Oryctolagus cuniculus	121-124
2905688-4	1988	Molecular cloning and sequencing of both the alleles of p53 gene revealed a base-pair change in codon 72 causing arginine----proline substitution in the allele with the additional BglII site.	Arginine	113-121	tumor protein p53	Homo sapiens	56-59
3233203-5	1988	Preincubation of bindin with fucan can almost completely protect bindin from inactivation by arginine-specific reagents, butanedione and phenylglyoxal, but only moderately slowed the inactivation by the histidine reagent diethyl pyrocarbonate.	Arginine	93-101	bindin	Strongylocentrotus purpuratus	17-23
3233203-5	1988	Preincubation of bindin with fucan can almost completely protect bindin from inactivation by arginine-specific reagents, butanedione and phenylglyoxal, but only moderately slowed the inactivation by the histidine reagent diethyl pyrocarbonate.	Arginine	93-101	bindin	Strongylocentrotus purpuratus	65-71
2460346-0	1988	Anti-(Arg-Gly-Asp-Ser) antibody and its interaction with fibronectin, fibrinogen and platelets.	Arginine	6-9	fibrinogen beta chain	Homo sapiens	70-80
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Arginine	48-51	fibronectin 1	Homo sapiens	74-85
3140744-9	1988	Supplemental arginine increased mean CD4 phenotype (% T-cells) on postoperative Days 1 and 7 from 25 +/- 9 to 43 +/- 14, compared with the values of 30 +/- 14 and 29 +/- 13 in the glycine group (p less than 0.05).	Arginine	13-21	CD4 molecule	Homo sapiens	37-40
3047161-0	1988	Insulin and glucagon secretory responses to arginine, glucagon, and theophylline during perifusion of human fetal islet-like cell clusters.	Arginine	44-52	insulin	Homo sapiens	0-7
3142779-0	1988	Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.	Arginine	54-64	interferon gamma	Mus musculus	0-16
3142779-0	1988	Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.	Arginine	54-64	tumor necrosis factor	Mus musculus	21-42
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Arginine	156-166	interferon gamma	Mus musculus	12-28
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Arginine	156-166	tumor necrosis factor	Mus musculus	58-79
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Arginine	156-166	tumor necrosis factor	Rattus norvegicus	81-85
3142779-6	1988	This result indicates that endogenously produced TNF is involved in the induction of the L-arginine-dependent effector mechanism when MDP is the co-stimulant with rIFN-gamma.	Arginine	89-99	tumor necrosis factor	Mus musculus	49-52
3047161-4	1988	At 13-15 weeks, glucose and arginine enhanced insulin release in some experiments, whereas glucagon and theophylline were always potent stimuli (mean response, 4-fold regardless of the glucose concentration).	Arginine	28-36	insulin	Homo sapiens	46-53
3047161-5	1988	At 17-22 weeks, both glucose alone (20 mmol/L) and arginine (10 mmol/L, with 2 mmol/L glucose) induced a small (1.4- to 1.5-fold) increase in insulin release.	Arginine	51-59	insulin	Homo sapiens	142-149
3417645-2	1988	The platelet membrane glycoprotein IIb-IIIa complex (GPIIb-IIIa) recognizes peptides containing the amino acid sequence Arg-Gly-Asp, a sequence present at two locations in the alpha chain of fibrinogen.	Arginine	120-123	fibrinogen beta chain	Homo sapiens	191-201
3139757-6	1988	Incubation of macrophages with IFN-gamma for 48 h in the presence of LPS inhibited H2O2 production but augmented NO2- release, whereas incubation in the presence of the arginine analog NG-monomethylarginine inhibited NO2- release but not H2O2 production.	Arginine	169-177	interferon gamma	Mus musculus	31-40
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Arginine	97-100	fibronectin 1	Homo sapiens	30-41
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Arginine	97-100	fibronectin 1	Homo sapiens	121-132
2458338-1	1988	The cell surface receptor for fibronectin is a heterodimeric membrane protein that recognizes an Arg-Gly-Asp sequence in fibronectin and that requires cations such as Mg2+ or Ca2+ for binding to fibronectin.	Arginine	97-100	fibronectin 1	Homo sapiens	121-132
2458338-8	1988	The increased fibronectin receptor activity in the presence of Mn2+ appeared to be due to an increase in the affinity of the receptor for the Arg-Gly-Asp sequence because a 110-kDa cell attachment fragment and a synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited liposome binding more effectively in the presence of Mn2+ than in the presence of Ca2+/Mg2+.	Arginine	142-145	fibronectin 1	Homo sapiens	14-25
2458338-8	1988	The increased fibronectin receptor activity in the presence of Mn2+ appeared to be due to an increase in the affinity of the receptor for the Arg-Gly-Asp sequence because a 110-kDa cell attachment fragment and a synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited liposome binding more effectively in the presence of Mn2+ than in the presence of Ca2+/Mg2+.	Arginine	249-252	fibronectin 1	Homo sapiens	14-25
2843815-5	1988	The second, shorter variant, apo-B(Arg1306----Term), is caused by mutation of a CpG dinucleotide in arginine codon 1306 converting it to a stop codon and predicting a protein of 1305 residues.	Arginine	100-108	apolipoprotein B	Homo sapiens	29-34
3207684-2	1988	We have used site-directed mutagenesis to independently alter the Gln residues at positions -1 and -2 of the human apoAI propeptide to Arg residues.	Arginine	135-138	apolipoprotein A1	Homo sapiens	115-120
2843239-0	1988	The secondary structure of apolipoproteins in human HDL3 particles after chemical modification of their tyrosine, lysine, cysteine or arginine residues.	Arginine	134-142	apolipoprotein E	Homo sapiens	27-42
2843239-4	1988	Modification of HDL3 by tetranitromethane (TNM) treatment, acetylation, reduction plus alkylation and 1,2-cyclohexanedione treatment derivatised tyrosine, lysine, cysteine and arginine residues, respectively, and caused alteration of the secondary structure of the HDL3 apolipoproteins to different extents.	Arginine	176-184	HDL3	Homo sapiens	16-20
2843239-0	1988	The secondary structure of apolipoproteins in human HDL3 particles after chemical modification of their tyrosine, lysine, cysteine or arginine residues.	Arginine	134-142	HDL3	Homo sapiens	52-56
2972276-7	1988	Using purified endopeptidase 24.11, we identified seven sites of hydrolysis in unlabelled alpha-hANP: the bonds Arg-4-Ser-5, Cys-7-Phe-8, Arg-11-Met-12, Arg-14-Ile-15, Gly-16-Ala-17, Gly-20-Leu-21 and Ser-25-Phe-26.	Arginine	112-115	natriuretic peptide A	Homo sapiens	96-100
2972276-7	1988	Using purified endopeptidase 24.11, we identified seven sites of hydrolysis in unlabelled alpha-hANP: the bonds Arg-4-Ser-5, Cys-7-Phe-8, Arg-11-Met-12, Arg-14-Ile-15, Gly-16-Ala-17, Gly-20-Leu-21 and Ser-25-Phe-26.	Arginine	138-141	natriuretic peptide A	Homo sapiens	96-100
2972276-7	1988	Using purified endopeptidase 24.11, we identified seven sites of hydrolysis in unlabelled alpha-hANP: the bonds Arg-4-Ser-5, Cys-7-Phe-8, Arg-11-Met-12, Arg-14-Ile-15, Gly-16-Ala-17, Gly-20-Leu-21 and Ser-25-Phe-26.	Arginine	138-141	natriuretic peptide A	Homo sapiens	96-100
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Arginine	51-54	regenerating family member 1 alpha	Homo sapiens	0-3
3137981-6	1988	In another severely affected patient, a mis-sense mutation results in a substitution of cysteine for arginine in the thrombin activation site at amino acid 1689.	Arginine	101-109	coagulation factor II, thrombin	Homo sapiens	117-125
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Arginine	51-54	regenerating family member 1 alpha	Homo sapiens	8-14
3147713-6	1988	PSP and PSP S1 are generated by the cleavage of an Arg-Ile bond in the N-terminal part of PSP S2-5.	Arginine	51-54	regenerating family member 1 alpha	Homo sapiens	8-11
2970411-4	1988	Acute insulin and C-peptide responses to intravenous pulses of different glucose amounts (0.33 g/kg and 5 g) and arginine (3 g) were significantly reduced by beta-endorphin infusion (P less than .01).	Arginine	113-121	insulin	Homo sapiens	18-27
2970411-6	1988	beta-Endorphin also inhibited glucose suppression of glucagon levels and augmented the glucagon response to arginine.	Arginine	108-116	proopiomelanocortin	Homo sapiens	0-14
2970411-4	1988	Acute insulin and C-peptide responses to intravenous pulses of different glucose amounts (0.33 g/kg and 5 g) and arginine (3 g) were significantly reduced by beta-endorphin infusion (P less than .01).	Arginine	113-121	proopiomelanocortin	Homo sapiens	158-172
3071528-2	1988	This alpha-thrombin-catalyzed proteolysis of protein Z occurred at a single peptide linkage, between Arg-365 and Gly-366, located in the COOH-terminal portion.	Arginine	101-104	coagulation factor II, thrombin	Homo sapiens	11-19
3260096-2	1988	Based on laboratory and clinical data from our institution, 113 patients with cirrhosis, portal hypertension, and acute hemorrhage from esophageal varices were treated with high-dose vasopressin arginine (1 to 1.5 U/min) to control the acute bleeding and reduce blood loss during portosystemic shunt operations.	Arginine	195-203	arginine vasopressin	Homo sapiens	183-194
2853705-6	1988	Cytochrome c containing Arg-37 and Gly-38 instead of Gly-37 and Arg-38 was slightly functional.	Arginine	24-27	cytochrome c, somatic	Homo sapiens	0-12
3191112-3	1988	At least two well-defined sequences in fibrinogen, Arg-Gly-Asp sequence of A alpha 95-97 and A alpha 572-574 and gamma 400-411, have been shown to interact with glycoprotein IIb-IIIa.	Arginine	51-54	fibrinogen beta chain	Homo sapiens	39-49
3395372-3	1988	Purified microvessels contained a membrane-bound carboxypeptidase which hydrolyzed the C-terminal Phe-Arg bond of both kallidin and bradykinin.	Arginine	102-105	kininogen 1	Homo sapiens	132-142
2466783-2	1988	This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu).	Arginine	201-204	interleukin 2	Homo sapiens	57-70
2466783-2	1988	This homology is one of six amino acids corresponding to interleukin-2 (IL-2) residues 14-19 (Leu-Glu-His-Leu-Leu-Leu) and to the carboxy terminal six amino acids of HIV envelope protein gp41 (Leu-Glu-Arg-Ile-Leu-Leu).	Arginine	201-204	interleukin 2	Homo sapiens	72-76
3170408-9	1988	After treatment with met-hGH, five of seven subjects had a suppressed GH response to stimulation from either L-dopa/arginine or submaximal exercise.	Arginine	116-124	growth hormone 1	Homo sapiens	26-28
3041313-4	1988	Interestingly, the insulin release during arginine load was significantly decreased in NT and IT as well as in DM patients.	Arginine	42-50	insulin	Homo sapiens	19-26
3041313-6	1988	Plasma glucagon after an arginine load was significantly higher in patients than in controls.	Arginine	25-33	glucagon	Homo sapiens	7-15
2838550-1	1988	Human rTNF-alpha stimulates the metabolism of murine peritoneal macrophages as demonstrated by an increased consumption of arginine and an increased release of L-ornithine.	Arginine	123-131	tumor necrosis factor	Rattus norvegicus	6-16
3196529-8	1988	C3a des Arg and C5a des Arg generation decreased 75% and 86%, respectively, as the polyvinylpyrolidone content of the casting solution was increased from 25 to 50%.	Arginine	24-27	complement C5a receptor 1	Homo sapiens	16-19
3240982-2	1988	The predominant amino acids in the phospholipase A2 were cysteine, glycine, arginine, and lysine, suggesting that it is a basic one.	Arginine	76-84	phospholipase A2 group IB	Homo sapiens	35-51
2968824-2	1988	The cell attachment site of fibronectin with its crucial arg-gly-asp(-ser) [RGD(S)]sequence is involved in these bindings.	Arginine	57-60	fibronectin 1	Homo sapiens	28-39
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 2	Homo sapiens	68-73
3391508-3	1988	About 80% of the 14C in albumin and transferrin was present as arginine, following conversion of [14C]ornithine via the urea cycle.	Arginine	63-71	transferrin	Rattus norvegicus	36-47
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 6	Homo sapiens	78-83
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 6	Homo sapiens	119-124
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 6	Homo sapiens	119-124
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 6	Homo sapiens	119-124
2851586-7	1988	As this fused protein had a Phe-Arg-Ala sequence at the junction of hIL-2 and BSF-2, it was possible to process mature BSF-2 from the fused BSF-2 by treatment with kallikrein and aminopeptidase P. From 1 liter of E. coli culture, 45 mg of mature BSF-2 was purified; it had a relative biological activity equal to that of natural BSF-2 purified from T cells.	Arginine	32-35	interleukin 6	Homo sapiens	119-124
3290622-1	1988	To elucidate the impact of subcutaneous insulin infusion (CSII) treatment on the glucagon response to intravenous (IV) arginine and to oral glucose a 6-month prospective randomized study in insulin-dependent diabetics was carried out.	Arginine	119-127	insulin	Homo sapiens	40-47
3131684-4	1988	Release of NO from the endothelial cells induced by bradykinin and the calcium ionophore A23187 was reversibly enhanced by infusions of L-arginine and L-citrulline, but not D-arginine or other close structural analogues.	Arginine	136-146	kininogen 1	Homo sapiens	52-62
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	24-27	angiotensinogen	Homo sapiens	32-35
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	136-139	angiotensinogen	Homo sapiens	32-35
2847349-9	1988	These results indicate that one or more tryptophan, arginine and tyrosine residues are essential for the recognition of thrombin by thrombomodulin whilst the carbohydrate side chain and the active site residues of the thrombin molecule are not involved in thrombomodulin binding.	Arginine	52-60	coagulation factor II, thrombin	Homo sapiens	120-128
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	136-139	angiotensinogen	Homo sapiens	32-35
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	136-139	angiotensinogen	Homo sapiens	32-35
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	136-139	angiotensinogen	Homo sapiens	32-35
3289535-5	1988	The results showed AGG (Arg) to AGT (Ser) point mutation, resulting in the change of interconnecting sequence of the two subunits from -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser-.	Arginine	136-139	angiotensinogen	Homo sapiens	32-35
2966812-5	1988	The cytoadhesive tetrapeptide portion of fibronectin, Arg-Gly-Asp-Ser (250-1,000 micrograms/ml), released 1.94 +/- 0.10 micrograms/ml of elastase from 10(7) neutrophils, in contrast to the lack of release by the control hexapeptide, Arg-Gly-Tyr-Ser-Leu-Gly.	Arginine	54-57	fibronectin 1	Homo sapiens	41-52
3131331-3	1988	Evidence is presented showing that proteolytic processing of pro-vWF by COS-1 cells occurs at the peptide bond between arginine and serine in the sequence Lys762-Arg763-Ser764, identical to endothelial cell-associated proteolysis.	Arginine	119-127	von Willebrand factor	Homo sapiens	65-68
3166991-4	1988	This local chain fold within residues Asp(7) to Val(20) may place the distant Phe residue near the Arg(16)-Gly(17) peptide bond which is cleaved by thrombin.	Arginine	99-102	coagulation factor II, thrombin	Homo sapiens	148-156
2838998-3	1988	Insulin response to arginine (5 g iv) and tolbutamide (1 g iv) were not affected by the same rate of prostaglandin E2 infusion.	Arginine	20-28	insulin	Homo sapiens	0-7
2897363-0	1988	Arginine for glycine substitution in the triple-helical domain of the products of one alpha 2(I) collagen allele (COL1A2) produces the osteogenesis imperfecta type IV phenotype.	Arginine	0-8	collagen type I alpha 2 chain	Homo sapiens	86-105
2897363-0	1988	Arginine for glycine substitution in the triple-helical domain of the products of one alpha 2(I) collagen allele (COL1A2) produces the osteogenesis imperfecta type IV phenotype.	Arginine	0-8	collagen type I alpha 2 chain	Homo sapiens	114-120
3286673-9	1988	In contrast, when the same amount of insulin was delivered intermittently, arginine-induced glucagon release was greatly reduced.	Arginine	75-83	insulin	Homo sapiens	37-44
3392382-10	1988	Prior to propranolol, arginine infusion caused greater glucagon release in cirrhotics (71 +/- 31 ng.h.ml-1) than in controls (33 +/- 17 ng.h.ml-1, P less than 0.02), but despite a similar insulin secretion (assessed from c-peptide), blood glucose did not increase.	Arginine	22-30	insulin	Homo sapiens	188-195
3392382-10	1988	Prior to propranolol, arginine infusion caused greater glucagon release in cirrhotics (71 +/- 31 ng.h.ml-1) than in controls (33 +/- 17 ng.h.ml-1, P less than 0.02), but despite a similar insulin secretion (assessed from c-peptide), blood glucose did not increase.	Arginine	22-30	insulin	Homo sapiens	221-230
3392212-2	1988	The chemotactic activity of human C5a des Arg is enhanced significantly by an anionic polypeptide (cochemotaxin) in normal human serum and plasma.	Arginine	42-45	complement C5a receptor 1	Homo sapiens	34-37
3392212-3	1988	The cochemotaxin attaches to sialic acid residues within the oligosaccharide chain of native C5a des Arg to form a complex with potent chemotactic activity for human PMN.	Arginine	101-104	complement C5a receptor 1	Homo sapiens	93-96
3392212-5	1988	Vitamin D-binding protein enhanced the chemotactic activity of native C5a des Arg, but had no effect on the chemotactic activity of either native C5a or FMLP.	Arginine	78-81	complement C5a receptor 1	Homo sapiens	70-73
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	Arginine	114-117	complement C5a receptor 1	Homo sapiens	106-109
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	Arginine	143-146	complement C5a receptor 1	Homo sapiens	135-138
3392213-0	1988	Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.	Arginine	104-107	complement C5a receptor 1	Homo sapiens	96-99
3392213-4	1988	However, as little as 0.01 nM Gc-globulin greatly enhanced the neutrophil chemotactic activity of C5a and its derivative, C5a des Arg over a wide concentration range.	Arginine	130-133	complement C5a receptor 1	Homo sapiens	98-101
3392213-4	1988	However, as little as 0.01 nM Gc-globulin greatly enhanced the neutrophil chemotactic activity of C5a and its derivative, C5a des Arg over a wide concentration range.	Arginine	130-133	complement C5a receptor 1	Homo sapiens	122-125
3392213-5	1988	The effect was most pronounced at nonchemotactic doses of C5a (0.01 nM) and C5a des Arg (1 nM).	Arginine	84-87	complement C5a receptor 1	Homo sapiens	76-79
3392213-10	1988	Finally, radioiodinated C5a or C5a des Arg formed a 1:1 complex with purified Gc-globulin when analyzed by gel filtration chromatography.	Arginine	39-42	complement C5a receptor 1	Homo sapiens	31-34
2453507-2	1988	We have generated antibodies against a synthetic peptide corresponding to the sequence of human von Willebrand factor (vWF) between residues Glu1737-Ser1750 which includes the Arg-Gly-Asp sequence common to several adhesive molecules.	Arginine	176-179	von Willebrand factor	Homo sapiens	96-117
2453507-2	1988	We have generated antibodies against a synthetic peptide corresponding to the sequence of human von Willebrand factor (vWF) between residues Glu1737-Ser1750 which includes the Arg-Gly-Asp sequence common to several adhesive molecules.	Arginine	176-179	von Willebrand factor	Homo sapiens	119-122
2453507-3	1988	Two anti-peptide antibodies, one polyclonal, and one monoclonal reacted with native vWF and inhibited its binding to platelet glycoprotein (GP) IIb-IIIa, but showed negligible cross-reactivity with fibrinogen, fibronectin, and vitronectin, three other molecules that contain the sequence Arg-Gly-Asp and bind to platelets.	Arginine	288-291	von Willebrand factor	Homo sapiens	84-87
3131325-4	1988	Amino-terminal sequence of CT14 was determined to be Ser-Ser-Pro-Gly-Ser-Pro-Gly-Thr-Pro-Gly-Ser-Arg-Ser-Arg-X-Pro-Ser-Leu-Pr o.	Arginine	97-100	sarcoma antigen 1	Homo sapiens	27-31
3131325-4	1988	Amino-terminal sequence of CT14 was determined to be Ser-Ser-Pro-Gly-Ser-Pro-Gly-Thr-Pro-Gly-Ser-Arg-Ser-Arg-X-Pro-Ser-Leu-Pr o.	Arginine	105-108	sarcoma antigen 1	Homo sapiens	27-31
3292407-9	1988	Optimal chemotactic concentrations of partially purified MNC-derived NCF were of comparable potency to FMLP and LTB4 and had about 60% of the activity of optimal concentrations of C5a, C5a-des-Arg and platelet-activating factor (PAF).	Arginine	193-196	complement C5a receptor 1	Homo sapiens	185-188
3286673-6	1988	In the normal men, insulin administration resulted in a significant decline of basal plasma glucagon and C-peptide levels and in a clear-cut decrease in the arginine-induced glucagon response.	Arginine	157-165	insulin	Homo sapiens	19-26
2836812-2	1988	Recombinant genes were constructed linking 5" and 3" flanking regions from tRNA genes which were active in vitro templates (tRNA(Val4), tRNA(Arg), tRNA(Ser7)) to the tRNA(Val3b) gene.	Arginine	141-144	transfer RNA:Valine-CAC 2-2	Drosophila melanogaster	166-176
3202961-1	1988	Guanidinobenzoatase is a cell surface protease associated with cells capable of migration, this enzyme is trypsin-like and cleaves the link peptide Gly-Arg-Gly-Asp of fibronectin.	Arginine	152-155	fibronectin 1	Homo sapiens	167-178
3145820-0	1988	Growth hormone (GH) responses to arginine and L-dopa alone and after GHRH pretreatment.	Arginine	33-41	growth hormone 1	Homo sapiens	0-14
3145820-0	1988	Growth hormone (GH) responses to arginine and L-dopa alone and after GHRH pretreatment.	Arginine	33-41	growth hormone 1	Homo sapiens	16-18
3145820-1	1988	In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.	Arginine	48-56	growth hormone 1	Homo sapiens	74-76
3145820-6	1988	Arginine infusion induced a rise in GH levels maximal at 45 min.	Arginine	0-8	growth hormone 1	Homo sapiens	36-38
3145820-7	1988	Following GHRH pretreatment the GH response to arginine was enhanced, with peak values of 19.3 +/- 6.4 vs 53.3 +/- 16.5 mU/l (mean +/- SEM) respectively (P less than 0.02).	Arginine	47-55	growth hormone releasing hormone	Homo sapiens	10-14
3145820-7	1988	Following GHRH pretreatment the GH response to arginine was enhanced, with peak values of 19.3 +/- 6.4 vs 53.3 +/- 16.5 mU/l (mean +/- SEM) respectively (P less than 0.02).	Arginine	47-55	growth hormone 1	Homo sapiens	10-12
3286012-2	1988	Site-specific deletion of the putative recognition sequence Arg-Gly-Asp-Ser or an Asp-to-Glu mutation decreased the adhesive activity of fibronectin fusion proteins expressed in E. coli by greater than or equal to 97%.	Arginine	60-63	fibronectin 1	Homo sapiens	137-148
2966812-5	1988	The cytoadhesive tetrapeptide portion of fibronectin, Arg-Gly-Asp-Ser (250-1,000 micrograms/ml), released 1.94 +/- 0.10 micrograms/ml of elastase from 10(7) neutrophils, in contrast to the lack of release by the control hexapeptide, Arg-Gly-Tyr-Ser-Leu-Gly.	Arginine	233-236	fibronectin 1	Homo sapiens	41-52
3260695-1	1988	Antithrombin III (AT III) inhibits thrombin via an arginine-serine interaction.	Arginine	51-59	coagulation factor II, thrombin	Homo sapiens	4-12
3294155-0	1988	Decreased insulin response to arginine after gastrectomy.	Arginine	30-38	insulin	Homo sapiens	10-17
3390901-2	1988	This glycoprotein possesses a cluster of four arginines at the N-terminus similar to the arginine rich binding sequence of apoprotein E (apoE) to the LDL-receptor.	Arginine	46-55	apolipoprotein E	Rattus norvegicus	123-135
3390901-2	1988	This glycoprotein possesses a cluster of four arginines at the N-terminus similar to the arginine rich binding sequence of apoprotein E (apoE) to the LDL-receptor.	Arginine	46-55	low density lipoprotein receptor	Rattus norvegicus	150-162
3390901-4	1988	Provided that the arginine rich sequence is responsible for the inhibition, a similarity in the characteristics of binding of apoE to the LDL (low density lipoprotein)- and chylomicron remnant-receptor is likely.	Arginine	18-26	apolipoprotein E	Rattus norvegicus	126-130
3290019-1	1988	To determine if the inhibiting effect of glucopenia on arginine-stimulated insulin secretion is impaired at the onset of autoimmune diabetes, the insulin response to arginine was studied at 5.6 and 2.8 mmol/l glucose in perfused pancreata isolated from BB/W rats on the first day of diabetes and from age-matched diabetes-prone BB/W rats without diabetes.	Arginine	55-63	insulin	Homo sapiens	75-82
3290019-3	1988	However, the arginine-stimulated insulin response in the diabetic group was only 16.5% lower during glucopenia compared to 79.1% lower in the nondiabetic controls.	Arginine	13-21	insulin	Homo sapiens	33-40
3394115-4	1988	Protein-chemical characterization of beta-thrombin showed that it had been cleaved at a single site (Arg73-Asn74) in the beta-chain, in contrast to human beta-thrombin obtained by autolysis, which is cleaved at both Arg-62 and Arg-73.	Arginine	101-104	coagulation factor II, thrombin	Homo sapiens	42-50
3394115-4	1988	Protein-chemical characterization of beta-thrombin showed that it had been cleaved at a single site (Arg73-Asn74) in the beta-chain, in contrast to human beta-thrombin obtained by autolysis, which is cleaved at both Arg-62 and Arg-73.	Arginine	216-219	coagulation factor II, thrombin	Homo sapiens	42-50
3041989-0	1988	Comparison of reaction rates in trypsin-catalysed transamidation of porcine insulin and its B29-arginine analogue.	Arginine	96-104	insulin	Homo sapiens	76-83
3041989-1	1988	[B29-Arginine]porcine insulin was prepared from des-(B23-30)-insulin and synthetic octapeptide with the aid of trypsin.	Arginine	5-13	insulin	Homo sapiens	22-29
3041989-1	1988	[B29-Arginine]porcine insulin was prepared from des-(B23-30)-insulin and synthetic octapeptide with the aid of trypsin.	Arginine	5-13	insulin	Homo sapiens	61-68
3351304-0	1988	A direct in vivo comparison of the inflammatory properties of human C5a and C5a des Arg in human skin.	Arginine	84-87	complement C5a receptor 1	Homo sapiens	76-79
3351304-2	1988	The C5a degradation product, C5a des Arg, is rapidly formed after exposure of C5a to serum carboxypeptidase N and may represent the relevant C5-derived inflammatory peptide in vivo.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	4-7
3351849-0	1988	The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists.	Arginine	30-38	angiotensinogen	Homo sapiens	75-89
3351304-2	1988	The C5a degradation product, C5a des Arg, is rapidly formed after exposure of C5a to serum carboxypeptidase N and may represent the relevant C5-derived inflammatory peptide in vivo.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	29-32
3351849-1	1988	The structure-antagonist activity relationship is described for analogues of [Sar1,Ile8]angiotensin II substituted in position 2 (arginine) and position 6 (histidine).	Arginine	130-138	angiotensinogen	Homo sapiens	88-102
3286820-11	1988	A short peptide derived from fibronectin"s cell-binding domain (Arg-Gly-Asp-Ser) also greatly reduced neurite outgrowth.	Arginine	64-67	fibronectin 1	Homo sapiens	29-40
3351304-2	1988	The C5a degradation product, C5a des Arg, is rapidly formed after exposure of C5a to serum carboxypeptidase N and may represent the relevant C5-derived inflammatory peptide in vivo.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	29-32
3351304-3	1988	To examine the biologic activity of human C5a des Arg in vivo and to compare it with that seen with human C5a, we purified and characterized homogeneous preparations of human C5a and C5a des Arg and injected them intradermally into seven normal volunteers.	Arginine	50-53	complement C5a receptor 1	Homo sapiens	42-45
3351304-4	1988	C5a des Arg exhibited biochemical and biologic properties in vitro that were different from those of C5a.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
3351304-5	1988	When injected into human skin, C5a des Arg was less potent than C5a, in respect to both minimal dose eliciting wheal and flare reactions and maximal wheal and flare elicited at a given dose, but C5a des Arg still elicited cutaneous wheal and flare reactions at physiologically relevant concentrations.	Arginine	39-42	complement C5a receptor 1	Homo sapiens	31-34
3351304-5	1988	When injected into human skin, C5a des Arg was less potent than C5a, in respect to both minimal dose eliciting wheal and flare reactions and maximal wheal and flare elicited at a given dose, but C5a des Arg still elicited cutaneous wheal and flare reactions at physiologically relevant concentrations.	Arginine	203-206	complement C5a receptor 1	Homo sapiens	31-34
3351304-6	1988	Histologically, C5a des Arg skin test sites showed dense polymorphonuclear neutrophil-rich infiltrates associated with leukocytoclasis, dermal mast cell degranulation, and endothelial cell swelling.	Arginine	24-27	complement C5a receptor 1	Homo sapiens	16-19
3351304-8	1988	Cutaneous wheal and flare reactions elicited by either C5a or C5a des Arg were partially inhibited by H1 antihistamines but were unaffected by selected nonsteroidal anti-inflammatory agents.	Arginine	70-73	complement C5a receptor 1	Homo sapiens	62-65
2964446-9	1988	Thus synthesis and maturation of the alpha-chain of beta-hexosaminidase includes two major proteolytic cleavages: the first, between alanine 22 and leucine 23, removes the signal peptide to generate the precursor form, whereas the second occurs between the dibasic amino acids, lysine 86 and arginine 87.	Arginine	292-300	Fc gamma receptor and transporter	Homo sapiens	37-48
2451243-9	1988	One fibronectin-like repeat contains a single Arg-Gly-Asp sequence.	Arginine	46-49	fibronectin 1	Homo sapiens	4-15
2828688-7	1988	Nucleotide sequencing established that the C3H p110 provirus was integrated within the R region of an endogenous VL30 long terminal repeat (LTR) in reverse orientation and that the virus differed from the infectious AKR p623 provirus by a point mutation, substituting Lys for Arg at the potential precursor cleavage site for gp70 and p15E.	Arginine	276-279	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	47-51
3383999-3	1988	Analogues of AVP and oxytocin (OT), modified at positions 1 (2-hydroxy-3-mercaptopropionic acid, deamino-3-mercaptopropionic acid), 2 (Phe), 4 (Arg, Val), 7 (Sar) or 8 (Orn) were synthesized and tested for uterotonic activity on human and rat uterine strips, and for vasopressor and antidiuretic activity in the rat in vivo.	Arginine	144-147	arginine vasopressin	Homo sapiens	13-16
3382440-1	1988	A certain resemblance of three-dimensional molecular organizations of the known peptide bioregulator bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) and the tentative cytophilic centre of the human IgE igercin (Arg-Ala-Val-Ser-Val-Asn-Pro-Gly-Lys) existing along with their pronounced structural similarity was shown by means of energy calculations.	Arginine	113-116	kininogen 1	Homo sapiens	101-111
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Arginine	83-91	coagulation factor II, thrombin	Homo sapiens	37-45
3279960-5	1988	The total insulin secretion with arginine (1, 5, 10, or 20 mM) was concentration dependent.	Arginine	33-41	insulin	Homo sapiens	10-17
2828688-11	1988	Substitution of Arg for Lys at the envelope precursor processing site of C3H p110 by site-directed mutagenesis is sufficient by itself to convert the virus to the XC-positive replication-competent phenotype.	Arginine	16-19	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	77-81
2451507-6	1988	Methylation occurs on an arginine residue in a single h.p.l.c.-resolvable peptide from the tryptic cleavage of MBP.	Arginine	25-33	myelin basic protein	Bos taurus	111-114
3373430-11	1988	Hydrophobic binding of these compounds to HSA at the warfarin site is possibly stabilized by the attraction of the delocalized negative charge to the basic lysine and arginine residues adjoining the lone tryptophan.	Arginine	167-175	albumin	Homo sapiens	42-45
2829978-7	1988	In particular, protein phosphatase T is endowed with phosphorylase phosphatase activity that is stimulated by protamine, histone H1 and heparin, it is inhibited by spermine, it does not bind to heparin-Sepharose and it readily dephosphorylates the phosphopeptide Arg-Arg-Leu-Ser(P)-Ile-Ser-Thr-Glu-Ser reproducing the phosphorylation site of the alpha-subunit of phosphorylase kinase.	Arginine	263-266	protein phosphatase 5, catalytic subunit	Rattus norvegicus	15-36
2829978-7	1988	In particular, protein phosphatase T is endowed with phosphorylase phosphatase activity that is stimulated by protamine, histone H1 and heparin, it is inhibited by spermine, it does not bind to heparin-Sepharose and it readily dephosphorylates the phosphopeptide Arg-Arg-Leu-Ser(P)-Ile-Ser-Thr-Glu-Ser reproducing the phosphorylation site of the alpha-subunit of phosphorylase kinase.	Arginine	267-270	protein phosphatase 5, catalytic subunit	Rattus norvegicus	15-36
2832737-2	1988	The mutation converted a CGA arginine codon to a TGA nonsense codon and generated a protein of 188 amino acids, instead of the usual 248 amino acids.	Arginine	29-37	chromogranin A	Homo sapiens	25-28
3422089-2	1988	These metabolic changes occur in parallel with L-citrulline, nitrate, and nitrate synthesis from L-arginine by EMT-6 cells.	Arginine	97-107	IL2 inducible T cell kinase	Mus musculus	111-114
3422089-4	1988	Once the effector pathway is induced in EMT-6 cells in the presence of amino acids, L-arginine is the only amino acid required for its function.	Arginine	84-94	IL2 inducible T cell kinase	Mus musculus	40-43
2962643-1	1988	A one-chain recombinant tissue-type plasminogen activator (EC 2.4.31.-) (tPA) analogue was constructed in which Arg-275 of the activation site was changed to Gly by site-directed mutagenesis.	Arginine	112-115	plasminogen activator, tissue type	Homo sapiens	24-57
3278954-5	1988	Arginine stimulated insulin and glucagon release was unaffected by either CGRP, or calcitonin.	Arginine	0-8	insulin	Homo sapiens	20-27
3059982-4	1988	In contrast to other mammals investigated, the three-domain precursor of vasopressin (vasopressin, MSEL-neurophysin and copeptin) is not completely processed in guinea pig and an intermediate precursor including MSEL-neurophysin and copeptin linked by an arginine residue has been isolated and sequenced.	Arginine	255-263	arginine vasopressin	Rattus norvegicus	73-84
3338452-5	1988	Cationic amino acid residues of hFABP (1 His, 15 Lys, 2 Arg) were screened for ionic fatty acid/protein interactions.	Arginine	56-59	fatty acid binding protein 3	Homo sapiens	32-37
3422479-10	1988	The geometric change (the rhodopsin "photoswitch") resulting from cis-trans isomerization in the first excited electronic state (S1), ultimately leads to RX (photoactivated rhodopsin, metarhodopsin II) and changes the activity of exobilayer groups, possibly causing dissociation of Lys-83 and Arg-85 from the carboxylate groups at positions 263 and 265.	Arginine	293-296	rhodopsin	Homo sapiens	26-35
3422479-10	1988	The geometric change (the rhodopsin "photoswitch") resulting from cis-trans isomerization in the first excited electronic state (S1), ultimately leads to RX (photoactivated rhodopsin, metarhodopsin II) and changes the activity of exobilayer groups, possibly causing dissociation of Lys-83 and Arg-85 from the carboxylate groups at positions 263 and 265.	Arginine	293-296	rhodopsin	Homo sapiens	173-182
3275655-8	1988	By relating the NH2-terminal amino acid sequences of these peptides to the sequence of the intact egg-specific protein, the protease was shown to cleave first at a Lys-Asn site and secondly at Arg-Asp.	Arginine	193-196	egg-specific protein	Bombyx mori	98-118
3068006-2	1988	Cells capable of attachment and growth in 5 mM concentrations of a peptide having the sequence Gly-Arg-Gly-Asp-Ser-Pro overproduce the cell surface receptor for fibronectin.	Arginine	99-102	fibronectin 1	Homo sapiens	161-172
2840973-2	1988	We have isolated a pro-hormone converting enzyme from bovine neural and intermediate lobe secretory vesicles that cleaves pro-vasopressin and pro-opiomelanocortin at Lys-Arg residues to yield vasopressin, and adrenocorticotropin/endorphin-related peptides, respectively.	Arginine	170-173	proopiomelanocortin	Bos taurus	142-162
3068006-1	1988	MG-63 human osteosarcoma cells were selected for attachment and growth in increasing concentrations of a synthetic peptide containing the cell attachment-promoting Arg-Gly-Asp (RGD) sequence derived from the cell-binding region of fibronectin.	Arginine	164-167	fibronectin 1	Homo sapiens	231-242
3053360-1	1988	It has been found that cationic protein breakdown product--3H-L-arginine labelled peptide fraction--interacts with fibrinogen in the presence of thrombin.	Arginine	62-72	fibrinogen beta chain	Homo sapiens	115-125
3180741-6	1988	It is concluded that on human neutrophils the arginine-rich polycations protamine and poly-L-Arg exhibit a competitive C5a receptor antagonism.	Arginine	46-54	complement C5a receptor 1	Homo sapiens	119-131
3180741-8	1988	It is hypothesized that molecular conformations of the arginine-rich polycations might bind reversibly to, and block negatively charged groups at the C5a-receptor sites.	Arginine	55-63	complement C5a receptor 1	Homo sapiens	150-162
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Arginine	77-80	fibrinogen beta chain	Homo sapiens	142-152
3053360-1	1988	It has been found that cationic protein breakdown product--3H-L-arginine labelled peptide fraction--interacts with fibrinogen in the presence of thrombin.	Arginine	62-72	coagulation factor II, thrombin	Homo sapiens	145-153
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Arginine	197-200	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-38
2852642-4	1988	The present study correlated chemotactic factors for PMNs with the level of C5a des Arg in BAL fluids obtained from patients with summer type HP.	Arginine	84-87	complement C5a receptor 1	Homo sapiens	76-79
3141687-6	1988	In a family with premature coronary artery disease and hyperapo-beta-lipoproteinaemia, a mutation in codon 4046 in exon 29 of the apolipoprotein B gene, a CGG to TGG transition produced a change from arginine, a positively charged amino acid, to tryptophan, a hydrophobic amino acid, at position 4,019 of the mature apolipoprotein B protein.	Arginine	200-208	apolipoprotein B	Homo sapiens	130-146
3141687-6	1988	In a family with premature coronary artery disease and hyperapo-beta-lipoproteinaemia, a mutation in codon 4046 in exon 29 of the apolipoprotein B gene, a CGG to TGG transition produced a change from arginine, a positively charged amino acid, to tryptophan, a hydrophobic amino acid, at position 4,019 of the mature apolipoprotein B protein.	Arginine	200-208	apolipoprotein B	Homo sapiens	316-332
3141688-4	1988	This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).	Arginine	268-271	apolipoprotein E	Homo sapiens	44-48
3141688-4	1988	This explains the significant effect of the apoE gene locus on the variability of plasma lipoprotein concentrations and moreover the implication of apoE alleles in the aetiology of multifactorial forms of hyperlipidaemia e.g. familial type III hyperlipidaemia (apoE2; arg158----cys) and polygenic hypercholesterolaemia (apoE4; cys112----arg).	Arginine	268-271	apolipoprotein E	Homo sapiens	148-152
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Arginine	197-200	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
2465527-3	1988	Site-directed mutagenesis of the c-src gene was used to generate c-src variants encoding pp60c-src proteins with the following amino acid alterations: tyr 90 to phe (pm90F); tyr 92 to phe (pm92F); arg 95 to either trp, lys, glu or gln (pm95W, 95K, 95E and 95Q, respectively), and deletion of residues 92-95 (dl92).	Arginine	197-200	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-38
2465527-4	1988	C-src variants encoding proteins with the alteration of arg 95 to trp, glu, or lys, or containing the deletion of residues 92-95, induced alterations in cell morphology and promoted growth in soft agar as well as changes in glucose transport and in vivo tyrosine phosphorylation of cellular proteins (including calpactin I heavy chain, p36).	Arginine	56-59	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
2447074-0	1987	Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.	Arginine	45-48	fibrinogen beta chain	Homo sapiens	134-144
3281173-4	1988	The aim of this work was to study the effects of fenfluramine on the insulin/GH ratio after arginine in obese subjects.	Arginine	92-100	insulin	Homo sapiens	69-76
3281173-4	1988	The aim of this work was to study the effects of fenfluramine on the insulin/GH ratio after arginine in obese subjects.	Arginine	92-100	growth hormone 1	Homo sapiens	77-79
3281173-10	1988	In the obese group the GH response to arginine was significantly lower than in controls.	Arginine	38-46	growth hormone 1	Homo sapiens	23-25
3281173-11	1988	Fenfluramine administration restored the subnormal GH response to arginine in obese subjects.	Arginine	66-74	growth hormone 1	Homo sapiens	51-53
3281173-13	1988	Fenfluramine administration diminished the insulin response to arginine.	Arginine	63-71	insulin	Homo sapiens	43-50
2963329-6	1988	FN bound appreciably to this column and was eluted much more efficiently by a solution of Arg-Gly-Asp-Ser-containing peptide than by a solution of related but inactive Arg-Gly-Glu-Ser-containing peptide.	Arginine	90-93	fibronectin 1	Homo sapiens	0-2
2963329-6	1988	FN bound appreciably to this column and was eluted much more efficiently by a solution of Arg-Gly-Asp-Ser-containing peptide than by a solution of related but inactive Arg-Gly-Glu-Ser-containing peptide.	Arginine	168-171	fibronectin 1	Homo sapiens	0-2
2447074-0	1987	Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.	Arginine	45-48	von Willebrand factor	Homo sapiens	150-171
3500868-9	1987	Substrates composed of synthetic peptides containing the Arg-Gly-Asp-Ser sequence supported thrombin-dependent adhesion but did not support ristocetin-dependent adhesion.	Arginine	57-60	coagulation factor II, thrombin	Homo sapiens	92-100
3693352-1	1987	Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of fibronectin and vitronectin.	Arginine	44-47	fibronectin 1	Homo sapiens	122-133
3329076-7	1987	In addition the morphological investigations were supplemented by quantitative biochemical studies measuring the non-secretory insulin release ("cytotoxic" release) from islets into the culture medium and their ability to respond to a consecutive stimulation by arginin with insulin and glucagon secretion.	Arginine	262-269	insulin	Homo sapiens	127-134
3329076-7	1987	In addition the morphological investigations were supplemented by quantitative biochemical studies measuring the non-secretory insulin release ("cytotoxic" release) from islets into the culture medium and their ability to respond to a consecutive stimulation by arginin with insulin and glucagon secretion.	Arginine	262-269	insulin	Homo sapiens	275-282
3500868-8	1987	Short synthetic peptides containing the sequence Arg-Gly-Asp-Ser effectively inhibited thrombin-dependent platelet adhesion to vWf substrates but had no effect on ristocetin-dependent adhesion.	Arginine	49-52	coagulation factor II, thrombin	Homo sapiens	87-95
3500868-8	1987	Short synthetic peptides containing the sequence Arg-Gly-Asp-Ser effectively inhibited thrombin-dependent platelet adhesion to vWf substrates but had no effect on ristocetin-dependent adhesion.	Arginine	49-52	von Willebrand factor	Homo sapiens	127-130
3116090-4	1987	Human C5a and C5a des Arg were purified to homogeneity and were found to stimulate IL-1 release from freshly obtained human mononuclear cells into the extracellular medium.	Arginine	22-25	complement C5a receptor 1	Homo sapiens	14-17
2830253-4	1987	The sequence of Ch1 has three substitutions from that of turkey muscle acylphosphatase; these are Ser from Ala at position 9, Ser from Arg at 47, and Lys from Asn at 83.	Arginine	135-138	SUN domain containing ossification factor	Gallus gallus	16-19
3478700-1	1987	Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence.	Arginine	200-203	albumin	Homo sapiens	47-60
3478700-1	1987	Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence.	Arginine	204-207	albumin	Homo sapiens	47-60
2960813-2	1987	Vasopressin antagonist analogues having a dibasic dipeptide tail, e.g., Arg-Arg-NH2 or Arg-Lys-NH2, attached directly to the cyclic hexapeptide ring are potent V2-receptor antagonists.	Arginine	72-76	arginine vasopressin	Homo sapiens	0-11
3118957-10	1987	The effect of phenylglyoxal on aldose reductase may be explained by the modification of a reactive thiol or lysine rather than an arginine residue.	Arginine	130-138	aldo-keto reductase family 1 member B	Homo sapiens	31-47
3328720-4	1987	The incremental areas under the immunoreactive insulin and C-peptide curves during arginine infusion were significantly greater (p less than 0.01) after oral than after intravenous glucose administration.	Arginine	83-91	insulin	Homo sapiens	47-54
3328720-4	1987	The incremental areas under the immunoreactive insulin and C-peptide curves during arginine infusion were significantly greater (p less than 0.01) after oral than after intravenous glucose administration.	Arginine	83-91	insulin	Homo sapiens	59-68
3116090-6	1987	The minimal concentration of C5a required was 25 ng/ml, whereas 125 ng/ml of C5a des Arg induced comparable amounts of IL-1.	Arginine	85-88	complement C5a receptor 1	Homo sapiens	77-80
3116090-8	1987	That the effect was due to the anaphylatoxins themselves, and not endotoxin contamination, was shown by negative Limulus amebocyte lysate tests and employing preincubation of C5a/C5a des Arg with polymyxin B.	Arginine	187-190	complement C5a receptor 1	Homo sapiens	175-178
3116090-8	1987	That the effect was due to the anaphylatoxins themselves, and not endotoxin contamination, was shown by negative Limulus amebocyte lysate tests and employing preincubation of C5a/C5a des Arg with polymyxin B.	Arginine	187-190	complement C5a receptor 1	Homo sapiens	179-182
3116090-10	1987	However, when endotoxin was added to C5a or C5a des Arg, significant synergism in the stimulation of IL-1 production was observed, occurring at various concentrations of either agent.	Arginine	52-55	complement C5a receptor 1	Homo sapiens	44-47
3116090-11	1987	A similar synergism with C5a/C5a des Arg was seen with interferon-gamma.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	25-28
3116090-11	1987	A similar synergism with C5a/C5a des Arg was seen with interferon-gamma.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	29-32
3116090-11	1987	A similar synergism with C5a/C5a des Arg was seen with interferon-gamma.	Arginine	37-40	interferon gamma	Homo sapiens	55-71
2830753-5	1987	Insulin release was also stimulated by the amino acids leucine and arginine, maximum stimulation for both amino acids occurring at 15 mmol/l.	Arginine	67-75	insulin	Homo sapiens	0-7
2827873-5	1987	Apparent dissociation rate constants thus estimated were 1.1, 1.1, 6.9, 5.8, and 13.9 min-1 for arginine vasopressin, arginine vasotocin, oxytocin, oxypressin, and [1-deamino, 9-D-alanineamide]arginine vasopressin, respectively.	Arginine	96-104	arginine vasopressin	Rattus norvegicus	105-116
3427134-8	1987	These sites are complementary for both lysine-and arginine-binding sites of the plasminogen molecule and are localized in the peripheral domains of the fibrinogen molecule.	Arginine	50-58	fibrinogen beta chain	Homo sapiens	152-162
2890159-6	1987	GIP is released from the precursor by processing at single arginine residues.	Arginine	59-67	gastric inhibitory polypeptide	Homo sapiens	0-3
2957232-5	1987	It is monomeric with a tendency to dimerize and appears to be distinct from the cell surface fibronectin receptors which interact with the Arg-Gly-Asp recognition site in the fibronectin molecule.	Arginine	139-142	fibronectin 1	Homo sapiens	93-104
2957232-5	1987	It is monomeric with a tendency to dimerize and appears to be distinct from the cell surface fibronectin receptors which interact with the Arg-Gly-Asp recognition site in the fibronectin molecule.	Arginine	139-142	fibronectin 1	Homo sapiens	175-186
3322910-2	1987	In addition, the arginine-induced acute proinsulin response to total immunoreactive insulin response ratio was greater in diabetic patients (n = 10) than in control subjects (n = 9) (8 +/- 2 vs 2 +/- 0.5%, p = 0.009), suggesting that increased islet secretion per se accounted for the increased ratio of proinsulin to immunoreactive insulin.	Arginine	17-25	insulin	Homo sapiens	304-314
3322910-2	1987	In addition, the arginine-induced acute proinsulin response to total immunoreactive insulin response ratio was greater in diabetic patients (n = 10) than in control subjects (n = 9) (8 +/- 2 vs 2 +/- 0.5%, p = 0.009), suggesting that increased islet secretion per se accounted for the increased ratio of proinsulin to immunoreactive insulin.	Arginine	17-25	insulin	Homo sapiens	84-91
3622513-8	1987	Residue 47 is His in beta 2 and Arg in the beta 1, gamma 1, and gamma 2 subunits, and in horse liver alcohol dehydrogenase.	Arginine	32-35	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	43-49
3622513-8	1987	Residue 47 is His in beta 2 and Arg in the beta 1, gamma 1, and gamma 2 subunits, and in horse liver alcohol dehydrogenase.	Arginine	32-35	tryptophanyl-tRNA synthetase 1	Homo sapiens	64-71
3622513-9	1987	Both His and Arg can make a hydrogen bond to a phosphate oxygen atom of NAD; hence the lower turnover rate of beta 1 apparently derives from a charge effect.	Arginine	13-16	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
3322910-2	1987	In addition, the arginine-induced acute proinsulin response to total immunoreactive insulin response ratio was greater in diabetic patients (n = 10) than in control subjects (n = 9) (8 +/- 2 vs 2 +/- 0.5%, p = 0.009), suggesting that increased islet secretion per se accounted for the increased ratio of proinsulin to immunoreactive insulin.	Arginine	17-25	insulin	Homo sapiens	40-50
3322910-2	1987	In addition, the arginine-induced acute proinsulin response to total immunoreactive insulin response ratio was greater in diabetic patients (n = 10) than in control subjects (n = 9) (8 +/- 2 vs 2 +/- 0.5%, p = 0.009), suggesting that increased islet secretion per se accounted for the increased ratio of proinsulin to immunoreactive insulin.	Arginine	17-25	insulin	Homo sapiens	43-50
3121486-1	1987	The effect of insulinhypoglycemia and arginine infusion on circulating concentrations of plasma growth hormone-releasing hormone (GHRH) and growth hormone (GH) has been studied in 24 children (4.4 to 14.3 years).	Arginine	38-46	growth hormone releasing hormone	Homo sapiens	96-128
3121486-1	1987	The effect of insulinhypoglycemia and arginine infusion on circulating concentrations of plasma growth hormone-releasing hormone (GHRH) and growth hormone (GH) has been studied in 24 children (4.4 to 14.3 years).	Arginine	38-46	growth hormone releasing hormone	Homo sapiens	130-134
3121486-8	1987	arginine hydrochloride did increase GH concentrations (2.0 +/- 0.6 ng/ml vs. 13.9 +/- 2.3 ng/ml; P less than 0.01) but did not change circulating plasma GHRH levels.	Arginine	0-22	growth hormone 1	Homo sapiens	36-38
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	fibronectin 1	Homo sapiens	148-159
2443508-0	1987	Human osteosarcoma cells resistant to detachment by an Arg-Gly-Asp-containing peptide overproduce the fibronectin receptor.	Arginine	55-58	fibronectin 1	Homo sapiens	102-113
2443508-2	1987	Cells capable of attachment and growth in 5-mM concentrations of a peptide having the sequence Gly-Arg-Gly-Asp-Ser-Pro overproduce the cell surface receptor for fibronectin.	Arginine	99-102	fibronectin 1	Homo sapiens	161-172
2443508-4	1987	In agreement with the resistance of the selected cells to detachment by the peptide, 25-fold more Arg-Gly-Asp-containing peptide is required to prevent the attachment of these cells to fibronectin-coated surfaces than is needed to inhibit the attachment of MG-63 cells to the same substrate.	Arginine	98-101	fibronectin 1	Homo sapiens	185-196
3305550-10	1987	Administration of arginine alone stimulated insulin from a mean basal level of 12.8 +/- 1.3 microU/mL to a peak level of 41.3 +/- 5.4 microU/mL.	Arginine	18-26	insulin	Homo sapiens	44-51
3305550-11	1987	Infusion of CCK at 12 and 24 pmol/kg X h augmented arginine-stimulated insulin levels to peaks of 62.5 +/- 13.9 and 63.0 +/- 4.0 microU/mL, respectively.	Arginine	51-59	cholecystokinin	Homo sapiens	12-15
3305550-11	1987	Infusion of CCK at 12 and 24 pmol/kg X h augmented arginine-stimulated insulin levels to peaks of 62.5 +/- 13.9 and 63.0 +/- 4.0 microU/mL, respectively.	Arginine	51-59	insulin	Homo sapiens	71-78
3305550-12	1987	Moreover, CCK nearly doubled the total amount of insulin secreted during the arginine infusion.	Arginine	77-85	cholecystokinin	Homo sapiens	10-13
3305550-12	1987	Moreover, CCK nearly doubled the total amount of insulin secreted during the arginine infusion.	Arginine	77-85	insulin	Homo sapiens	49-56
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Arginine	62-65	angiotensinogen	Canis lupus familiaris	48-53
3655744-15	1987	Between the E2 and E1 genes, there is a stretch of seven amino acids, five of which are arginines, which may serve as cleavage sites for a trypsin-like protease.	Arginine	88-97	kallikrein related peptidase 11	Homo sapiens	139-160
3116411-12	1987	An (Arg-6, Phe-7) heptapeptide extension of [Met]-enkephalin entered the deep pocket and assumed an extended conformation in the main cavity like the pentapeptide.	Arginine	4-7	proopiomelanocortin	Homo sapiens	45-60
3686693-0	1987	[Inhibitory effect of methyl esters of arginine-containing oligopeptides on thrombin and trypsin].	Arginine	39-47	coagulation factor II, thrombin	Homo sapiens	76-84
3304721-0	1987	A large molecular form of glucagon-like peptide-1 (GLP-1) immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects.	Arginine	121-129	glucagon	Homo sapiens	26-49
3304721-0	1987	A large molecular form of glucagon-like peptide-1 (GLP-1) immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects.	Arginine	121-129	glucagon	Homo sapiens	51-56
3304721-7	1987	Moreover, the free GLP-1 concentrations in plasma before and after an arginine load were shown to be about equal by reverse phase HPLC.	Arginine	70-78	glucagon	Homo sapiens	19-24
3632667-1	1987	The activity of protein kinase C (PKC) toward arginine-rich substrates was greatly stimulated by sulfate and phosphate, but not by monovalent anions.	Arginine	46-54	proline rich transmembrane protein 2	Homo sapiens	16-32
3632667-1	1987	The activity of protein kinase C (PKC) toward arginine-rich substrates was greatly stimulated by sulfate and phosphate, but not by monovalent anions.	Arginine	46-54	proline rich transmembrane protein 2	Homo sapiens	34-37
3632667-3	1987	Anionic proteins such as bovine serum albumin also promoted PKC activity toward certain substrates that were characterized by either high arginine or high lysine content.	Arginine	138-146	proline rich transmembrane protein 2	Homo sapiens	60-63
3112154-1	1987	The active site arginine-143 of human Cu,Zn superoxide dismutase has been replaced by lysine or by isoleucine.	Arginine	16-24	superoxide dismutase 1	Homo sapiens	38-64
3611085-8	1987	Thus, the results of this modification study indicate that at least 1 arginine residue is essential for the expression of catalytic activity of the calmodulin-regulated phosphatase.	Arginine	70-78	calmodulin 1	Homo sapiens	148-158
3611800-0	1987	Rapid and simple measurement of human C5a-des-Arg level in plasma or serum using monoclonal antibodies.	Arginine	46-49	complement C5a receptor 1	Homo sapiens	38-41
3611800-4	1987	One of the antibodies reacted with C5a-des-Arg, but not with C5a and C5.	Arginine	43-46	complement C5a receptor 1	Homo sapiens	35-38
2885238-3	1987	Glucose-potentiated insulin secretion was calculated as the slope of the curve relating increasing ambient glucose levels to the acute insulin response to an intravenous pulse of 5 g of L-arginine.	Arginine	186-196	insulin	Homo sapiens	20-27
3038101-1	1987	Rhodamines 110 and 123, and rhodamine 110 linked via peptide bonds to Arg, Cbz-Arg and Cbz-Ile-Pr-Arg interact with free base porphyrins or cytochrome C.	Arginine	70-73	cytochrome c, somatic	Homo sapiens	140-152
3648093-4	1987	As reported previously, the chemotactic activity of C5a des Arg was enhanced significantly by the addition of an anionic polypeptide (cochemotaxin) present in normal serum and plasma.	Arginine	60-63	complement C5a receptor 1	Homo sapiens	52-55
3648093-5	1987	Interestingly, both purified lupus inhibitor and Bb inhibited the chemotactic activity exhibited by mixtures of C5a des Arg and its cochemotaxin.	Arginine	120-123	complement C5a receptor 1	Homo sapiens	112-115
3648093-6	1987	This effect was due, most likely, to their ability to neutralize the enhancing effect of the cochemotaxin on the chemotactic activity of C5a des Arg.	Arginine	145-148	complement C5a receptor 1	Homo sapiens	137-140
3036276-1	1987	Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain.	Arginine	24-27	fibrinogen beta chain	Homo sapiens	6-16
2890540-0	1987	Effects of arginine and arginine plus somatostatin infusion on insulin release in diabetic patients submitted to pancreas allotransplantation.	Arginine	24-32	insulin	Homo sapiens	63-70
2890540-1	1987	The present study was aimed at evaluating the role of the Autonomic Nervous System (ANS) in the insulin (IRI) response to arginine in humans.	Arginine	122-130	insulin	Homo sapiens	96-103
3556281-2	1987	Only the maximum acute insulin response to intravenous arginine was lower in the siblings than in the matched controls (P less than .05); other measures of insulin secretion, including the acute insulin response to glucose or arginine, the second-phase insulin response to glucose, and the slope of glucose potentiation, were not significantly different.	Arginine	55-63	insulin	Homo sapiens	23-30
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Arginine	23-26	fibronectin 1	Homo sapiens	75-86
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Arginine	23-26	fibronectin 1	Homo sapiens	143-154
3294880-1	1987	To analyze B-cell mechanisms in obesity, we measured the relationship (slope of potentiation) between glucose levels and acute insulin responses (AIR) to isoproterenol or arginine in nondiabetic subjects ranging from lean to markedly obese.	Arginine	171-179	insulin	Homo sapiens	127-134
3323444-0	1987	Arginine-induced insulin and growth hormone secretion in children with nutritional rickets.	Arginine	0-8	insulin	Homo sapiens	17-24
3323444-1	1987	We evaluated arginine-induced insulin and growth hormone (GH) secretion in ten children with vitamin D deficiency rickets and compared these values with those of eight age-matched control children.	Arginine	13-21	insulin	Homo sapiens	30-37
3323444-1	1987	We evaluated arginine-induced insulin and growth hormone (GH) secretion in ten children with vitamin D deficiency rickets and compared these values with those of eight age-matched control children.	Arginine	13-21	growth hormone 1	Homo sapiens	58-60
3300283-2	1987	Work using classical paper chromatographic techniques for detecting free amino acids indicated that the octapeptide, des-(Arg9)-bradykinin, enters these cells and its amino-terminal arginine residue is released by cytosolic aminopeptidase-P.	Arginine	182-190	kininogen 1	Homo sapiens	128-138
3300283-2	1987	Work using classical paper chromatographic techniques for detecting free amino acids indicated that the octapeptide, des-(Arg9)-bradykinin, enters these cells and its amino-terminal arginine residue is released by cytosolic aminopeptidase-P.	Arginine	182-190	X-prolyl aminopeptidase 1	Homo sapiens	214-240
3300283-3	1987	We have used 1H NMR to monitor directly the release of arginine from bradykinin.	Arginine	55-63	kininogen 1	Homo sapiens	69-79
3108036-0	1987	Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein.	Arginine	16-19	regenerating family member 1 alpha	Homo sapiens	70-94
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Arginine	234-237	regenerating family member 1 alpha	Homo sapiens	34-37
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Arginine	234-237	regenerating family member 1 alpha	Homo sapiens	145-148
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Arginine	234-237	regenerating family member 1 alpha	Homo sapiens	180-186
3108036-4	1987	This report demonstrates that: in PSP S2-5 the amino-terminal is blocked; the C-terminus is alike in every form; the single polypeptide chain of PSP S2-5 is converted into that of PSP S1 or PSP by the specific trypsin cleavage of the Arg-Ile bond.	Arginine	234-237	regenerating family member 1 alpha	Homo sapiens	145-148
2953683-7	1987	These data suggest that the highly charged molecule heparin can modify the physical and biological properties of atriopeptins, perhaps by binding to the numerous arginine residues (i.e., 5 arginine residues in atriopeptin-28) in the atriopeptin molecules.	Arginine	162-170	natriuretic peptide A	Homo sapiens	113-124
2953683-7	1987	These data suggest that the highly charged molecule heparin can modify the physical and biological properties of atriopeptins, perhaps by binding to the numerous arginine residues (i.e., 5 arginine residues in atriopeptin-28) in the atriopeptin molecules.	Arginine	162-170	natriuretic peptide A	Homo sapiens	210-221
2953683-7	1987	These data suggest that the highly charged molecule heparin can modify the physical and biological properties of atriopeptins, perhaps by binding to the numerous arginine residues (i.e., 5 arginine residues in atriopeptin-28) in the atriopeptin molecules.	Arginine	189-197	natriuretic peptide A	Homo sapiens	113-124
2953683-7	1987	These data suggest that the highly charged molecule heparin can modify the physical and biological properties of atriopeptins, perhaps by binding to the numerous arginine residues (i.e., 5 arginine residues in atriopeptin-28) in the atriopeptin molecules.	Arginine	189-197	natriuretic peptide A	Homo sapiens	210-221
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	117-120	fibrinogen beta chain	Homo sapiens	81-91
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	117-120	Fc gamma receptor and transporter	Homo sapiens	140-151
2884233-6	1987	On the other hand, basal and arginine-stimulated glucagon and insulin secretions were not significantly affected by these plasma concentrations of intravenous somatostatin suggesting that the exocrine pancreas might be more sensitive to somatostatin than the islet cells.	Arginine	29-37	insulin	Homo sapiens	62-69
2827873-5	1987	Apparent dissociation rate constants thus estimated were 1.1, 1.1, 6.9, 5.8, and 13.9 min-1 for arginine vasopressin, arginine vasotocin, oxytocin, oxypressin, and [1-deamino, 9-D-alanineamide]arginine vasopressin, respectively.	Arginine	96-104	arginine vasopressin	Rattus norvegicus	202-213
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Arginine	39-42	optineurin	Homo sapiens	7-10
3108248-6	1987	The sequence of the propeptide (Arg-Ser-Phe-Trp-Gln-His) differs in two positions from that of mammalian apoA-I.	Arginine	32-35	apolipoprotein A1	Homo sapiens	105-111
3106345-3	1987	We found that the peptides with sequences identical with A alpha 148-161 and A alpha 149-161 of human fibrinogen accelerate the plasminogen activation by t-PA, whereas the corresponding peptides in which lysine residues A alpha 157 had been replaced by valine or arginine had no accelerating capacity.	Arginine	263-271	fibrinogen beta chain	Homo sapiens	102-112
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Arginine	39-42	optineurin	Homo sapiens	157-160
3472221-2	1987	Nucleotide sequence analysis has revealed the primary structure of a 170-amino acid precursor protein that encodes both neurotensin and the neurotensin-like peptide neuromedin N. The peptide-coding domains are located in tandem near the carboxyl terminus of the precursor and are bounded and separated by the paired, basic amino acid residues Lys-Arg.	Arginine	347-350	neurotensin	Canis lupus familiaris	120-131
3032797-10	1987	Arginine, a scavenger of hypochlorite, significantly depressed the ability of sCM-treated neutrophils to kill amoebae and also prevented the amoebicidal properties of the MPO-H2O2-halide system.	Arginine	0-8	myeloperoxidase	Homo sapiens	171-174
3037722-0	1987	Inhibition of von Willebrand factor binding to platelets by two recognition site peptides: the pentadecapeptide of the carboxy terminus of the fibrinogen gamma chain and the tetrapeptide arg-gly-asp-ser.	Arginine	187-190	von Willebrand factor	Homo sapiens	14-35
3331517-2	1987	On the other hand, an oral administration of arginine resulted in an anabolic state: decreases in serum leucine and isoleucine concentrations, reductions in serum glucose and free fatty acid contents and a rapid increase in serum insulin level.	Arginine	45-53	insulin	Homo sapiens	230-237
3331517-3	1987	It was assumed that the effect of ornithine administration may be exerted through an activation of hepatic System A transport and that of arginine is an insulin-mediated action.	Arginine	138-146	insulin	Homo sapiens	153-160
3472221-2	1987	Nucleotide sequence analysis has revealed the primary structure of a 170-amino acid precursor protein that encodes both neurotensin and the neurotensin-like peptide neuromedin N. The peptide-coding domains are located in tandem near the carboxyl terminus of the precursor and are bounded and separated by the paired, basic amino acid residues Lys-Arg.	Arginine	347-350	neurotensin	Canis lupus familiaris	140-151
3597579-5	1987	The facile detection of arginine-containing fragments in the tryptic digest of beta-melanocyte stimulating hormone as a model compound could be achieved by comparison with a chromatogram obtained with ultraviolet absorption detection at 215 nm.	Arginine	24-32	proopiomelanocortin	Homo sapiens	79-114
3603738-1	1987	The capacity of methyl esters of arginine-containing substrates to inhibit the proteolytic activity of thrombin is studied.	Arginine	33-41	coagulation factor II, thrombin	Homo sapiens	103-111
3554869-0	1987	Circulating serum phenylalanine concentrations and the effect of arginine infusion on plasma levels of growth hormone and insulin in treated phenylketonuric children.	Arginine	65-73	growth hormone 1	Homo sapiens	103-117
3115018-0	1987	Arginine induced growth hormone (hGH) response and paradoxical hGH secretion stimulated by TRH in diabetes mellitus.	Arginine	0-8	growth hormone 1	Homo sapiens	17-31
3115018-1	1987	Growth hormone (hGH) reserve following arginine administration and the paradoxical hGH response to thyrotropin-releasing hormone (TRH) were studied in 30 diabetics without evidence of vascular complications.	Arginine	39-47	growth hormone 1	Homo sapiens	0-14
3035002-7	1987	The TRH- and arginine-induced increases in prolactin and growth hormone were significantly greater after administration of naloxone (p less than 0.05).	Arginine	13-21	prolactin	Homo sapiens	43-52
3580304-8	1987	Fibrinogen Sheffield and Paris VI were identified as A alpha Arg 16----His substitutions and fibrinogens London VI and Madrid II were found to be heterozygous for an unknown substitution preventing thrombin cleavage at A alpha Arg 16.	Arginine	61-64	fibrinogen beta chain	Homo sapiens	0-10
3311576-3	1987	Growth hormone (somatotropin) is secreted by the anterior pituitary gland in response to various stimuli, including exercise, hypoglycemia, and arginine.	Arginine	144-152	growth hormone 1	Homo sapiens	0-14
3311576-3	1987	Growth hormone (somatotropin) is secreted by the anterior pituitary gland in response to various stimuli, including exercise, hypoglycemia, and arginine.	Arginine	144-152	growth hormone 1	Homo sapiens	16-28
3108170-4	1987	Short-term lithium treatment significantly reduced the insulin response to IVGTT25, arginine and tolbutamide.	Arginine	84-92	insulin	Homo sapiens	55-62
3035002-7	1987	The TRH- and arginine-induced increases in prolactin and growth hormone were significantly greater after administration of naloxone (p less than 0.05).	Arginine	13-21	growth hormone 1	Homo sapiens	57-71
3819394-6	1987	Monocyte adherence to microvascular endothelial cell monolayers was stimulated in a dose-response fashion in the presence of C5a des arg or FMLP to a maximum mean adherence of 47.2% +/- 2.9 or 43.8% +/- 2.2, respectively.	Arginine	133-136	complement C5a receptor 1	Homo sapiens	125-128
3586712-2	1987	TNF was found to augment the capacity of peritoneal macrophages to convert 14C-labeled arginine into L-ornithine and to release L-ornithine into the culture medium.	Arginine	87-95	tumor necrosis factor	Homo sapiens	0-3
3819394-7	1987	C5a des arg or FMLP stimulated monocytes to adhere to monolayers of human vascular smooth muscle cells, human dermal fibroblasts, or serum-coated plastic wells in a comparable fashion as to endothelial cells.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
3819394-8	1987	The simultaneous presence of both chemotactic peptides C5a des arg and FMLP in the assay system stimulated monocyte adherence to the same degree as either stimulus alone.	Arginine	63-66	complement C5a receptor 1	Homo sapiens	55-58
3567178-2	1987	To examine the acceptor specificity of affinity-purified insulin receptor/kinase, hydroxyamino acid containing analogues of the synthetic peptide substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly were prepared.	Arginine	156-159	insulin	Homo sapiens	57-64
3567178-2	1987	To examine the acceptor specificity of affinity-purified insulin receptor/kinase, hydroxyamino acid containing analogues of the synthetic peptide substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly were prepared.	Arginine	160-163	insulin	Homo sapiens	57-64
3819394-9	1987	This finding suggested that those monocytes stimulated to adhere by C5a des arg were the same subpopulation responding to FMLP.	Arginine	76-79	complement C5a receptor 1	Homo sapiens	68-71
3819394-9	1987	This finding suggested that those monocytes stimulated to adhere by C5a des arg were the same subpopulation responding to FMLP.	Arginine	76-79	formyl peptide receptor 1	Homo sapiens	122-126
3819394-11	1987	The pretreatment of monocytes with either C5a des arg or FMLP prior to the adherence assay induced stimulus-specific desensitization of monocyte adherence.	Arginine	50-53	complement C5a receptor 1	Homo sapiens	42-45
3819394-14	1987	These data suggest that the stimulated adhesion of monocytes to endothelial cells by C5a des arg or FMLP represents primarily an effect of these chemotactic peptides on the monocyte.	Arginine	93-96	complement C5a receptor 1	Homo sapiens	85-88
2879756-5	1987	The basal somatostatin level and its release in response to 10 mM arginine, 11 mM glucose, and 500 pg/ml glucagon during venous perfusion was significantly higher than that during arterial perfusion.	Arginine	66-74	somatostatin	Canis lupus familiaris	10-22
3643926-2	1987	Sequencing of the NH2-terminal region of the light chain reported herein identified the third kallikrein cleavage site of high molecular weight kininogen as Arg-437.	Arginine	157-160	kininogen 1	Homo sapiens	122-153
3814824-1	1987	The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding.	Arginine	24-27	fibrinogen beta chain	Homo sapiens	48-58
3814824-1	1987	The alpha chain 572-574 Arg-Gly-Asp sequence of fibrinogen appears to play only a minor role in platelet aggregation based on the ability of fibrinogen preparations lacking alpha chain carboxyterminal segments to support platelet aggregation, but synthetic Arg-Gly-Asp-Ser (RGDS) peptides are capable of inhibiting platelet aggregation and fibrinogen binding.	Arginine	257-260	fibrinogen beta chain	Homo sapiens	48-58
3106550-6	1987	BALB/c apoA-II contains one residue each of histidine and arginine, neither of which are found in the human A-II protein.	Arginine	58-66	NLR family pyrin domain containing 3	Homo sapiens	10-14
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Arginine	74-77	fibronectin 1	Homo sapiens	144-155
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Arginine	74-77	fibrinogen beta chain	Homo sapiens	170-180
2954262-1	1987	The relationship between chemical modifications of arginine derivatives and inhibitory activity to trypsin, plasmin and glandular kallikrein was investigated comparing with that of thrombin and concluded as follows: The hydrophobic binding pocket, which has been reported previously to be stereogeometrically very similar in trypsin and thrombin, corresponded to the length of ethylpiperidine.	Arginine	51-59	coagulation factor II, thrombin	Homo sapiens	337-345
3028489-4	1987	In the second, the amino acids of VIP, buried in the active site of the receptor, were protected and one arginine residue of bound VIP was successfully modified using azidophenylglyoxal.	Arginine	105-113	vasoactive intestinal peptide	Homo sapiens	131-134
3108419-1	1987	Antibodies to a synthetic carboxy-terminal peptide (Cys-Ser-Leu-Arg-Lys-Arg-Lys-Arg-Ser-Arg-Abu) (gamma-C-TP) of mouse interferon-gamma (MuIFN-gamma) were produced in rabbits.	Arginine	64-67	interferon gamma	Mus musculus	119-135
3567158-3	1987	Amino acid sequence analysis of a peptide isolated from a lysyl endopeptidase digest of the abnormal thrombin indicated that Arg-418 (equivalent to Asn-101 in the chymotrypsin numbering system) had been replaced by Trp.	Arginine	125-128	coagulation factor II, thrombin	Homo sapiens	101-109
3567158-5	1987	The Arg----Trp replacement found in the thrombin portion of prothrombin Tokushima appears to reduce its interaction with various substrates including fibrinogen and platelet receptors and accounts for the recurrent bleeding episode observed in the propositus.	Arginine	4-7	coagulation factor II, thrombin	Homo sapiens	40-48
2436653-9	1987	A four-residue basic sequence (Arg-Ser-Lys-Arg) was identified upstream of the amino-terminal Asn of C5a, thereby specifying a beta alpha-chain orientation for the promolecule form of murine C5.	Arginine	31-34	hemolytic complement	Mus musculus	101-104
2436653-9	1987	A four-residue basic sequence (Arg-Ser-Lys-Arg) was identified upstream of the amino-terminal Asn of C5a, thereby specifying a beta alpha-chain orientation for the promolecule form of murine C5.	Arginine	43-46	hemolytic complement	Mus musculus	101-104
3030741-4	1987	Concomitant with reduced calcitonin binding, both mutants exhibited increased vasopressin binding (greater than 272 fmol [[3H]Arg]vasopressin bound/mg) compared to parental (166 fmol bound/mg).	Arginine	126-129	vasopressin	Sus scrofa	78-89
3030335-1	1987	Bradykinin is degraded in human plasma by a carboxypeptidase to yield desArg9-bradykinin (DBK) which is then digested by angiotensin-converting enzyme (ACE) to the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe.	Arginine	73-76	kininogen 1	Homo sapiens	0-10
3030335-1	1987	Bradykinin is degraded in human plasma by a carboxypeptidase to yield desArg9-bradykinin (DBK) which is then digested by angiotensin-converting enzyme (ACE) to the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe.	Arginine	73-76	kininogen 1	Homo sapiens	78-88
3030335-1	1987	Bradykinin is degraded in human plasma by a carboxypeptidase to yield desArg9-bradykinin (DBK) which is then digested by angiotensin-converting enzyme (ACE) to the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe.	Arginine	73-76	angiotensin I converting enzyme	Homo sapiens	121-150
3030335-1	1987	Bradykinin is degraded in human plasma by a carboxypeptidase to yield desArg9-bradykinin (DBK) which is then digested by angiotensin-converting enzyme (ACE) to the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe.	Arginine	73-76	angiotensin I converting enzyme	Homo sapiens	152-155
3545826-1	1987	A synthetic gene for bovine pancreatic ribonuclease A (RNase A) has been expressed in Escherichia coli as a fusion protein with beta-galactosidase linked by the tetrapeptide Ile-Glu-Gly-Arg.	Arginine	186-189	ribonuclease pancreatic	Bos taurus	39-53
3545826-1	1987	A synthetic gene for bovine pancreatic ribonuclease A (RNase A) has been expressed in Escherichia coli as a fusion protein with beta-galactosidase linked by the tetrapeptide Ile-Glu-Gly-Arg.	Arginine	186-189	ribonuclease pancreatic	Bos taurus	55-62
3036070-1	1987	The amino acid sequence of human C1r A chain was determined, from sequence analysis performed on fragments obtained from C1r autolytic cleavage, cleavage of methionyl bonds, tryptic cleavages at arginine and lysine residues, and cleavages by staphylococcal proteinase.	Arginine	195-203	complement C1r	Homo sapiens	33-36
3108419-1	1987	Antibodies to a synthetic carboxy-terminal peptide (Cys-Ser-Leu-Arg-Lys-Arg-Lys-Arg-Ser-Arg-Abu) (gamma-C-TP) of mouse interferon-gamma (MuIFN-gamma) were produced in rabbits.	Arginine	72-75	interferon gamma	Mus musculus	119-135
3805026-6	1987	Both H12 and L10 (gamma 402-411) completely eluted GPIIb-IIIa bound to immobilized Arg-Gly-Asp peptides.	Arginine	83-86	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	13-16
3103680-2	1987	Tissue-type plasminogen activator (t-PA) is homologous to mammalian serine proteases and contains an apparent activation cleavage site at arginine-275.	Arginine	138-146	plasminogen activator, tissue type	Homo sapiens	0-33
3103680-2	1987	Tissue-type plasminogen activator (t-PA) is homologous to mammalian serine proteases and contains an apparent activation cleavage site at arginine-275.	Arginine	138-146	plasminogen activator, tissue type	Homo sapiens	35-39
3103680-3	1987	To clarify the functional consequences of cleavage at arginine-275 of t-PA, site-specific mutagenesis was performed to convert arginine-275 to a glutamic acid.	Arginine	54-62	plasminogen activator, tissue type	Homo sapiens	70-74
2885895-5	1987	Unusually delayed or prolonged growth hormone response to arginine infusion was observed in non-responders.	Arginine	58-66	growth hormone 1	Homo sapiens	31-45
2434337-2	1987	A glycine to arginine substitution at HA1 135 abrogates recognition by a panel of T cell clones which, according to their reactivity for natural virus variants, have different antigenic specificities: three clones recognize a synthetic peptide (HA1 residues 118-138) but fail to recognize the monoclonal antibody-selected mutant (Gly135/Arg).	Arginine	13-21	Rho GTPase activating protein 45	Mus musculus	38-41
2434337-2	1987	A glycine to arginine substitution at HA1 135 abrogates recognition by a panel of T cell clones which, according to their reactivity for natural virus variants, have different antigenic specificities: three clones recognize a synthetic peptide (HA1 residues 118-138) but fail to recognize the monoclonal antibody-selected mutant (Gly135/Arg).	Arginine	13-21	Rho GTPase activating protein 45	Mus musculus	245-248
3436616-5	1987	In the obese group the GH response to arginine was significantly lower than in control group.	Arginine	38-46	growth hormone 1	Homo sapiens	23-25
3436616-6	1987	Fenfluramine administration restored the subnormal GH response to arginine in obese subjects.	Arginine	66-74	growth hormone 1	Homo sapiens	51-53
2446997-0	1987	The interaction between fibrinogen and 3H-arginine labelled proteins derived from fibrosarcoma in the presence of thrombin.	Arginine	42-50	coagulation factor II, thrombin	Homo sapiens	114-122
3805128-6	1987	For inhibiting interactions with laminin or native type I collagen gels, Gly-Arg-Gly-Asp-Ser was only weakly active, but the inverted peptide Ser-Asp-Gly-Arg unexpectedly continued to display inhibitory activity for both attachment proteins in both cell types.	Arginine	77-80	laminin, beta 2 (laminin S)	Gallus gallus	33-40
3447169-0	1987	Contribution of arginine (HC3) 141 alpha to the Bohr effect of the fourth binding step in the reaction of ligand with human hemoglobin.	Arginine	16-24	CYCS pseudogene 24	Homo sapiens	26-29
3027230-0	1986	Arginine infusion blocks the action of parathyroid hormone but not arginine vasopressin on the renal tubule in man.	Arginine	0-8	parathyroid hormone	Homo sapiens	39-58
3569692-1	1986	The in vivo and in vitro effects of a hypoglycaemic fragment of human growth hormone containing the sequence H2N-Ile-Pro-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala-Met-Leu-COOH (hGH 4-15) on 2-deoxy-[1-14C]-D-glucose uptake in adipocytes were studied.	Arginine	129-132	growth hormone 1	Homo sapiens	70-84
3827867-1	1986	Three Arg/Lys-Xaa bonds in the B-chain of human alpha-thrombin were found to be the major autolytic sites.	Arginine	6-9	coagulation factor II, thrombin	Homo sapiens	54-62
3025664-10	1986	This sequence difference resulted in an arginine being coded for in clone p53-H-1 and a proline being coded for at the equivalent position in clone p53-H-19.	Arginine	40-48	tumor protein p53	Homo sapiens	74-77
3782473-0	1986	Attachment of human C5a des Arg to its cochemotaxin is required for maximum expression of chemotactic activity.	Arginine	28-31	complement C5a receptor 1	Homo sapiens	20-23
3782473-1	1986	The chemotactic activity of human C5a des Arg is enhanced significantly by an anionic polypeptide (cochemotaxin) in normal human serum and plasma.	Arginine	42-45	complement C5a receptor 1	Homo sapiens	34-37
3782473-2	1986	We have found that the cochemotaxin attaches to the oligosaccharide chain of native C5a des Arg to form a complex with potent chemotactic activity for human polymorphonuclear leukocytes.	Arginine	92-95	complement C5a receptor 1	Homo sapiens	84-87
2437225-3	1986	LO-22 also bound efficiently to IFN-alpha D which is only 83% related to IFN-alpha A, but which also has arginine at position 23.	Arginine	105-113	interferon alpha 1	Homo sapiens	32-43
2437225-3	1986	LO-22 also bound efficiently to IFN-alpha D which is only 83% related to IFN-alpha A, but which also has arginine at position 23.	Arginine	105-113	interferon alpha 1	Homo sapiens	32-41
2437225-4	1986	These results strongly suggest that LO-22 recognizes a conserved epitope among IFN-alpha subtypes in which arginine at position 23 is involved.	Arginine	107-115	interferon alpha 1	Homo sapiens	79-88
2946928-8	1986	ANF1-126-Arg-Arg was specifically cleaved followed incubation with thrombin to yield the 98-amino acid N-terminal fragment and the C-terminal atriopeptin, AP28-Arg-Arg.	Arginine	9-12	coagulation factor II	Rattus norvegicus	67-75
2946928-8	1986	ANF1-126-Arg-Arg was specifically cleaved followed incubation with thrombin to yield the 98-amino acid N-terminal fragment and the C-terminal atriopeptin, AP28-Arg-Arg.	Arginine	13-16	coagulation factor II	Rattus norvegicus	67-75
2946928-8	1986	ANF1-126-Arg-Arg was specifically cleaved followed incubation with thrombin to yield the 98-amino acid N-terminal fragment and the C-terminal atriopeptin, AP28-Arg-Arg.	Arginine	13-16	coagulation factor II	Rattus norvegicus	67-75
2946928-8	1986	ANF1-126-Arg-Arg was specifically cleaved followed incubation with thrombin to yield the 98-amino acid N-terminal fragment and the C-terminal atriopeptin, AP28-Arg-Arg.	Arginine	13-16	coagulation factor II	Rattus norvegicus	67-75
2946928-9	1986	Processing of ANF1-126-Arg-Arg by reperfusion through an isolated heart or by incubation in serum yielded identical metabolites to those generated by incubation with thrombin.	Arginine	27-30	coagulation factor II	Rattus norvegicus	166-174
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Arginine	119-127	arginine vasopressin	Homo sapiens	181-192
3542595-4	1986	arginine could be perfectly normalized if strict blood glucose regulations were achieved with appropriate insulin treatment.	Arginine	0-8	insulin	Homo sapiens	106-113
3771562-10	1986	The substitution of cysteine for arginine was confirmed by tryptic digestion of 14C-carboxymethylated prothrombin Barcelona.	Arginine	33-41	coagulation factor II, thrombin	Homo sapiens	102-113
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Arginine	147-150	arginine vasopressin	Homo sapiens	50-61
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Arginine	119-127	arginine vasopressin	Homo sapiens	50-61
3021739-6	1986	This indicates that the enzymatic cleavage in the vasopressin precursor occurred primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor.	Arginine	147-150	arginine vasopressin	Homo sapiens	181-192
2880743-0	1986	The effect of lysine acetylsalicylate on somatostatin inhibition of insulin secretion induced by arginine.	Arginine	97-105	insulin	Homo sapiens	68-75
2880743-3	1986	Aim of this study is to determine the inhibitory effect of SRIF on insulin secretion induced by arginine after the administration of lysine acetylsalicylate (LAS) in a dose which inhibits the endogenous synthesis of prostaglandins.	Arginine	96-104	insulin	Homo sapiens	67-74
2876887-6	1986	The highest ARG density associated with S-14 section was found in the area postrema, followed in decreasing order by the subfornical organ and the organum vasculosum lamina terminalis region.	Arginine	12-15	thyroid hormone responsive	Rattus norvegicus	40-44
2880743-12	1986	After arginine administration the typical biphasic insulin response was observed with a precocious peak at 3 min and a late peak at 30 min.	Arginine	6-14	insulin	Homo sapiens	51-58
3798577-0	1986	[Inhibition of the proteolytic activity of thrombin by methyl esters of arginine-containing oligopeptides].	Arginine	72-80	coagulation factor II, thrombin	Homo sapiens	43-51
3771519-7	1986	Thus, specific 125I-fibronectin binding was inhibited by excess unlabeled fibrinogen or fibronectin, the anti-GP IIb-IIIa monoclonal antibody 10E5, the decapeptide from the carboxyl terminus of the fibrinogen gamma-chain, and the tetrapeptide Arg-Gly-Asp-Ser from the cell-binding domain of fibronectin.	Arginine	243-246	fibronectin 1	Homo sapiens	20-31
3532968-10	1986	Shunt loss of hepatotrophic factor was estimated by insulin response (change in plasma concentration over 10 minutes: AUC) after arginine stimulation.	Arginine	129-137	insulin	Homo sapiens	52-59
3767132-0	1986	Airways hyperreactivity and inflammation produced by aerosolization of human C5A des arg.	Arginine	85-88	complement C5a receptor 1	Homo sapiens	77-80
3767132-2	1986	Inflammation was induced in large airways (greater than 1.0 mm) by aerosolization of the complement chemotactic factor, C5a des arg, which was isolated from activated human serum.	Arginine	29-32	complement C5a receptor 1	Homo sapiens	120-123
3099250-0	1986	Serum insulin-like growth factors I and II concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation.	Arginine	102-110	insulin	Homo sapiens	81-88
3099250-2	1986	We also evaluated arginine-induced insulin and GH secretion.	Arginine	18-26	insulin	Homo sapiens	35-42
3099250-6	1986	GH responses to arginine were depressed in the three malnourished groups and improved significantly in marasmic-kwashiorkor and marasmic children after nutritional rehabilitation.	Arginine	16-24	growth hormone 1	Homo sapiens	0-2
3099250-7	1986	Insulin responses to arginine were impaired in kwashiorkor, and marasmic-kwashiorkor children and improved significantly after refeeding.	Arginine	21-29	insulin	Homo sapiens	0-7
3767132-4	1986	Four hours after exposure to C5a des arg, the animals exhibited evidence of significant bronchoconstriction and hyperinflation.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	29-32
3767132-8	1986	Saline-treated animals also demonstrated a neutrophil infiltration, but significantly less than those treated with C5a des arg.	Arginine	123-126	complement C5a receptor 1	Homo sapiens	115-118
3767132-11	1986	Granulocyte dependence of the effects of C5a des arg was partially established by abrogation of these effects when the animals were rendered granulocytopenic with nitrogen mustard.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
3767132-12	1986	We conclude that the physiologic responses of the airways to C5a des arg were largely granulocyte dependent.	Arginine	69-72	complement C5a receptor 1	Homo sapiens	61-64
3798577-1	1986	The kinetics of thrombin-catalyzed hydrolysis of the esters of arginine-containing di- and tripeptides at pH 8.5 and the inhibition of fibrinogen-thrombin reaction by these compounds are studied.	Arginine	63-71	coagulation factor II, thrombin	Homo sapiens	16-24
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	fibrinogen beta chain	Homo sapiens	90-100
3539143-2	1986	An approximately 6,000-fold increase in the second order association rate constant with human thrombin was observed (48 M-1 X s-1 for the normal protein to 3.1 X 10(5) M-1 X s-1 for the arginine mutant), confirming previously observed data using bovine thrombin (Owen, M.C., Brennan, S.O., Lewis, J.H.	Arginine	186-194	coagulation factor II, thrombin	Homo sapiens	94-102
3028526-6	1986	This pituitary serine protease was shown to selectively cleave human pro-opiomelanocortin (POMC)-derived peptides at both pairs of basic residues and C-terminal to specific Arg residues, all known to be cleaved in vivo.	Arginine	173-176	coagulation factor II, thrombin	Homo sapiens	15-30
3028526-6	1986	This pituitary serine protease was shown to selectively cleave human pro-opiomelanocortin (POMC)-derived peptides at both pairs of basic residues and C-terminal to specific Arg residues, all known to be cleaved in vivo.	Arginine	173-176	proopiomelanocortin	Homo sapiens	69-89
3028526-6	1986	This pituitary serine protease was shown to selectively cleave human pro-opiomelanocortin (POMC)-derived peptides at both pairs of basic residues and C-terminal to specific Arg residues, all known to be cleaved in vivo.	Arginine	173-176	proopiomelanocortin	Homo sapiens	91-95
2427364-4	1986	Two amino acid replacements between human and bovine alpha 2-macroglobulin were found at positions +3 (Val/Ala) and +4 (Leu/Arg) from the Glu moiety of the thioester.	Arginine	124-127	pregnancy zone protein	Bos taurus	53-74
3540079-4	1986	The responses of plasma glucose, insulin and glucagon to arginine were not significantly different between addicts and controls, while the growth hormone rise was significantly greater in addicts.	Arginine	57-65	insulin	Homo sapiens	33-40
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	fibronectin 1	Homo sapiens	102-113
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	von Willebrand factor	Homo sapiens	119-140
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	von Willebrand factor	Homo sapiens	142-145
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	fibrinogen beta chain	Homo sapiens	180-190
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	von Willebrand factor	Homo sapiens	205-208
2944746-10	1986	260, 4133-4138] have shown that a tetrapeptide, Arg-Gly-Asp-Ser, inhibited the binding of fibrinogen, fibronectin, and von Willebrand factor (vWf) to stimulated platelets and that fibrinogen competes with vWf and fibronectin for binding.	Arginine	48-51	fibronectin 1	Homo sapiens	213-224
3536894-4	1986	The complete prorenin sequence was then excised from the renatured hybrid protein using blood coagulation factor Xa, a proteinase which is highly specific for the tetrapeptide insert Ile-Glu-Gly-Arg introduced between the 9 amino-terminal residues of the trp E gene product and the first amino acid (Thr 1) of prorenin.	Arginine	195-198	thyroid hormone receptor beta	Homo sapiens	300-305
3019665-7	1986	Both the prosequence, composed of two D domains (D1, D2), and mature vWF harbor an arg-gly-asp ("R-G-D") sequence which has been implicated in cell-attachment functions.	Arginine	83-86	von Willebrand factor	Homo sapiens	69-72
2426110-6	1986	A beta-turn at residues Arg-18-Gly-19 may be present as a minor component.	Arginine	24-27	amyloid beta precursor protein	Homo sapiens	0-6
3755681-6	1986	Interesting features of the chromogranin A structure include repeated clusters of glutamic acid residues, the occurrence of eight potential dibasic cleavage sites, six of which are located in the C-terminal domain, and the presence, in the N-terminal domain, of -Arg-Gly-Asp- (RGD), a three amino acid sequence involved in the binding of several constitutively secreted proteins to cell membranes.	Arginine	263-266	chromogranin A	Bos taurus	28-42
3738745-7	1986	Neutrophil selective chemotactic desensitization toward C5a/C5a des Arg during the on bypass and postbypass periods was evident in the control group (0.41 and 0.76 cm specific migration, respectively) and prevented in the MPSS group (1.55 and 2.00 cm specific migration, respectively).	Arginine	68-71	complement C5a receptor 1	Homo sapiens	56-59
3738745-7	1986	Neutrophil selective chemotactic desensitization toward C5a/C5a des Arg during the on bypass and postbypass periods was evident in the control group (0.41 and 0.76 cm specific migration, respectively) and prevented in the MPSS group (1.55 and 2.00 cm specific migration, respectively).	Arginine	68-71	complement C5a receptor 1	Homo sapiens	60-63
3522576-0	1986	Reaction of neutral endopeptidase 24.11 (enkephalinase) with arginine reagents.	Arginine	61-69	membrane metalloendopeptidase	Homo sapiens	12-39
3522576-1	1986	The effect of the arginine-specific reagents phenylglyoxal and butanedione on the activity of neutral endopeptidase 24.11 ("enkephalinase") was determined.	Arginine	18-26	membrane metalloendopeptidase	Homo sapiens	94-121
3527696-2	1986	Sequential Edman degradation and carboxypeptidase digestion unambiguously establish that histones H2A, H2B, H3 and H4 are selectively cleaved at the carboxyl side of Arg 11, Lys 20, Arg 26 and Arg 19 respectively and that the C-terminal sequences remain unaffected.	Arginine	166-169	histone cluster 1, H2bg	Rattus norvegicus	103-117
3527696-2	1986	Sequential Edman degradation and carboxypeptidase digestion unambiguously establish that histones H2A, H2B, H3 and H4 are selectively cleaved at the carboxyl side of Arg 11, Lys 20, Arg 26 and Arg 19 respectively and that the C-terminal sequences remain unaffected.	Arginine	182-185	histone cluster 1, H2bg	Rattus norvegicus	103-117
3527696-2	1986	Sequential Edman degradation and carboxypeptidase digestion unambiguously establish that histones H2A, H2B, H3 and H4 are selectively cleaved at the carboxyl side of Arg 11, Lys 20, Arg 26 and Arg 19 respectively and that the C-terminal sequences remain unaffected.	Arginine	182-185	histone cluster 1, H2bg	Rattus norvegicus	103-117
3734095-5	1986	Approximately 60% of the 14C in albumin and transferrin was present as arginine while the remainder was found in proline and related amino acids.	Arginine	71-79	transferrin	Rattus norvegicus	44-55
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Arginine	28-31	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Arginine	36-39	coagulation factor II, thrombin	Homo sapiens	115-123
3016716-10	1986	The peptide Tyr-His-His-Lys-Arg-Lys-Arg-Lys-Gln-Arg-Gly-Asp-Val was labeled with 125I to quantitate its binding to thrombin-stimulated platelets; at saturation, 59,990 molecules were bound per cell (Kd = 3.8 X 10(-7) M).	Arginine	36-39	coagulation factor II, thrombin	Homo sapiens	115-123
3719940-6	1986	We conclude that this patient has a mutation in one of his alleles for apolipoprotein E that differs from the frequently seen Arg----Cys change.	Arginine	126-129	apolipoprotein E	Homo sapiens	71-87
3711069-2	1986	With metal ion-free calmodulin, limited proteolysis occurred at Arg 37 and Arg 106 with a cleavage ratio of 1 to 5, resulting in fragments consisting of residues 1-37, 38-148, 1-106 and 107-148.	Arginine	64-67	calmodulin	Bos taurus	20-30
3718539-1	1986	Carboxypeptidase N removed the C-terminal arginine from bradykinin or lysyl bradykinin to leave the des-Arg derivative of each, and no further degradation occurred regardless of enzyme concentration or time of incubation.	Arginine	42-50	kininogen 1	Homo sapiens	56-66
3718539-1	1986	Carboxypeptidase N removed the C-terminal arginine from bradykinin or lysyl bradykinin to leave the des-Arg derivative of each, and no further degradation occurred regardless of enzyme concentration or time of incubation.	Arginine	42-50	kininogen 1	Homo sapiens	76-86
3718539-4	1986	However, angiotensin converting enzyme degraded des-Arg9-bradykinin in plasma or serum prior to such Phe removal to yield the pentapeptide Arg-Pro-Pro-Gly-Phe and the tripeptide Ser-Pro-Phe.	Arginine	52-55	kininogen 1	Homo sapiens	57-67
3524673-12	1986	The protein also contains the tetrapeptide sequence Arg-Gly-Asp-Ser (at residues 1744-1747), which may be a cell attachment site, as in fibronectin.	Arginine	52-55	fibronectin 1	Homo sapiens	136-147
3019322-1	1986	The interaction of the chemoattractant des-Arg74-C5a (C5a des Arg) with its receptor on a human monocyte-like cell line, U-937, was examined.	Arginine	43-46	complement C5a receptor 1	Homo sapiens	49-52
3019322-1	1986	The interaction of the chemoattractant des-Arg74-C5a (C5a des Arg) with its receptor on a human monocyte-like cell line, U-937, was examined.	Arginine	43-46	complement C5a receptor 1	Homo sapiens	54-57
3019322-2	1986	The data obtained suggest that C5a des Arg receptor expression is regulated by the extracellular concentration of C5a des Arg itself.	Arginine	39-42	complement C5a receptor 1	Homo sapiens	31-34
3019322-2	1986	The data obtained suggest that C5a des Arg receptor expression is regulated by the extracellular concentration of C5a des Arg itself.	Arginine	39-42	complement C5a receptor 1	Homo sapiens	114-117
2875693-8	1986	L-634,366 is a novel compound possessing a broad spectrum of antisecretory activity; in vitro studies suggested a weak noncompetitive inhibition of the histamine-H2 receptor in atria.	Arginine	0-2	histamine H2 receptor	Cavia porcellus	152-173
3720344-1	1986	Aminopeptidase III activity was demonstrated in extracts from several different mammalian lenses by the hydrolysis of Arg-MCA at pH 6.0.	Arginine	118-121	carboxypeptidase Q	Homo sapiens	0-14
2482748-0	1986	One- and two-dimensional 1H NMR study of the substance P fragment ARG-PRO-Lys-Pro.	Arginine	66-69	tachykinin precursor 1	Homo sapiens	45-56
3711336-2	1986	First, using leukocyte aggregometry, we demonstrated that the addition of a recently developed rabbit anti-human polyclonal antibody to C5a des arg to endotoxin-activated plasma prevented leukocyte aggregation in vitro.	Arginine	144-147	complement C5a receptor 1	Homo sapiens	136-139
3711336-3	1986	We then administered the anti-C5a des arg antibody to septic primates (Macaca fascicularis).	Arginine	38-41	complement C5a receptor 1	Homo sapiens	30-33
3711336-10	1986	This study demonstrates that treatment with rabbit anti-human C5a des arg antibodies attenuates ARDS and some of the systemic manifestations of sepsis in nonhuman primates.	Arginine	70-73	complement C5a receptor 1	Homo sapiens	62-65
3516448-11	1986	After intravenous arginine, the increase in proinsulin was less than that of insulin, and it declined more slowly.	Arginine	18-26	insulin	Homo sapiens	44-54
3516448-11	1986	After intravenous arginine, the increase in proinsulin was less than that of insulin, and it declined more slowly.	Arginine	18-26	insulin	Homo sapiens	47-54
3711069-2	1986	With metal ion-free calmodulin, limited proteolysis occurred at Arg 37 and Arg 106 with a cleavage ratio of 1 to 5, resulting in fragments consisting of residues 1-37, 38-148, 1-106 and 107-148.	Arginine	75-78	calmodulin	Bos taurus	20-30
3091296-5	1986	The GHRH data in these patients are in agreement with those in older literature on hGH responsiveness to stimuli such as L-dopa, arginine and insulin induced hypoglycaemia.	Arginine	129-137	growth hormone releasing hormone	Homo sapiens	4-8
2871684-5	1986	The stimulatory effect of arginine on GH and insulin was counteracted by the peptide at the P less than 0.001 and P less than 0.02 significance level, respectively.	Arginine	26-34	insulin	Homo sapiens	45-52
2421134-4	1986	In all 3 patients growth hormone (GH) responses to intravenous arginine were depressed and in 2 of the 3 patients, a GH-dependent 150 K serum protein carrier of IGF was absent.	Arginine	63-71	growth hormone 1	Homo sapiens	18-32
3514759-2	1986	At concentrations that were chemotactic for PMN, C5a (0.1 nM), C5a des Arg (5.0 nM), and FMLP (1.0 nM) significantly reduced the percentage of PMN that adhered to endothelial monolayers.	Arginine	71-74	complement C5a receptor 1	Homo sapiens	63-66
3514759-3	1986	Adherence also was reduced by C5a des Arg that was generated by incubating (37 degrees C, 30 min) fresh human serum with either zymosan or purified C5a.	Arginine	38-41	complement C5a receptor 1	Homo sapiens	30-33
3514759-3	1986	Adherence also was reduced by C5a des Arg that was generated by incubating (37 degrees C, 30 min) fresh human serum with either zymosan or purified C5a.	Arginine	38-41	complement C5a receptor 1	Homo sapiens	148-151
3514759-6	1986	High concentrations of C5a des Arg (up to 80 nM) neither enhanced adherence of PMN to endothelial cells nor decreased PMN migration.	Arginine	31-34	complement C5a receptor 1	Homo sapiens	23-26
3515118-0	1986	Basal and glucose- and arginine-stimulated serum concentrations of insulin, C-peptide, and glucagon in hyperthyroid patients.	Arginine	23-31	insulin	Homo sapiens	67-74
3515118-0	1986	Basal and glucose- and arginine-stimulated serum concentrations of insulin, C-peptide, and glucagon in hyperthyroid patients.	Arginine	23-31	insulin	Homo sapiens	76-85
3515118-3	1986	The insulin response was similar in the hyperthyroid and normal subjects after glucose administration and significantly lower during arginine infusion in the hyperthyroid patients.	Arginine	133-141	insulin	Homo sapiens	4-11
2421134-4	1986	In all 3 patients growth hormone (GH) responses to intravenous arginine were depressed and in 2 of the 3 patients, a GH-dependent 150 K serum protein carrier of IGF was absent.	Arginine	63-71	growth hormone 1	Homo sapiens	34-36
2420006-2	1986	The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.	Arginine	110-113	fibronectin 1	Homo sapiens	170-181
3515118-4	1986	The serum C-peptide response to both glucose and arginine administration was markedly blunted in the hyperthyroid patients, and the plasma glucagon response to arginine infusion was decreased.	Arginine	49-57	insulin	Homo sapiens	10-19
2422782-5	1986	These results indicate that fibrin protected plasmin from inactivation by alpha 2AP, leading to cleavage of Arg(42)-Ala(43) bond in beta-chain of fibrin which seems to be less susceptible to plasmin than the same bond in fibrinogen.	Arginine	108-111	serpin family F member 1	Sus scrofa	74-83
2420006-5	1986	This platelet receptor is related to the previously identified fibronectin and vitronectin receptors in that it recognizes an Arg-Gly-Asp sequence but differs from the other receptors in its wider specificity toward various adhesive proteins.	Arginine	126-129	fibronectin 1	Homo sapiens	63-74
2420006-2	1986	The binding of both of these proteins to platelets is inhibited by synthetic peptides containing the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.	Arginine	110-113	fibrinogen beta chain	Homo sapiens	224-234
3754463-3	1986	A fragment of MLCK containing the phosphorylation site was shown to have the amino acid sequence Ala-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu- Ser-Ser.	Arginine	101-104	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	14-18
3457517-2	1986	All fourteen showed a blunted GH response to insulin hypoglycaemia and, in twelve, the GH response to arginine stimulation was also subnormal.	Arginine	102-110	growth hormone 1	Homo sapiens	87-89
3005300-3	1986	The purified kinase exhibited a specific activity of 300 nmol/min/mg of protein at 30 degrees C using the synthetic peptide, Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, as substrate in the presence of insulin.	Arginine	125-128	insulin	Homo sapiens	210-217
3005300-3	1986	The purified kinase exhibited a specific activity of 300 nmol/min/mg of protein at 30 degrees C using the synthetic peptide, Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, as substrate in the presence of insulin.	Arginine	129-132	insulin	Homo sapiens	210-217
3633200-4	1986	We hypothesized that modification of arginine residues may prevent cleavage of HMW kininogen, since the initial kallikrein-induced cleavage sites on the HMW kininogen molecule are at the NH2 terminal and the COOH terminal of the bradykinin-containing portion of the molecule, each of which contains arginine.	Arginine	37-45	kininogen 1	Homo sapiens	229-239
3633200-5	1986	We found that modification with butanedione of four arginine residues in the HMW kininogen molecule prevented bradykinin release, which results from cleavage of HMW kininogen.	Arginine	52-60	kininogen 1	Homo sapiens	110-120
2869020-2	1986	A small amount of insulin was also detectable in the incubation medium when hormone secretion was stimulated by the addition of arginine or theophylline.	Arginine	128-136	insulin	Homo sapiens	18-25
3484755-4	1986	In this report, we demonstrate that this variant protein also has greatly increased inhibitory activity towards the arginine-specific enzymes of the contact system of plasma proteolysis (Factor XIa, kallikrein, and Factor XIIf), in contrast to normal alpha 1-antitrypsin, which has modest to no inhibitory activity towards these enzymes.	Arginine	116-124	serpin family A member 1	Homo sapiens	251-270
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Arginine	291-294	fibronectin 1	Homo sapiens	129-140
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Arginine	291-294	fibronectin 1	Homo sapiens	129-140
3514020-1	1986	The peak levels of serum growth hormone (GH) obtained in response to administration of insulin and arginine in 26 children with constitutional delay in growth (CDG) are compared to similar test results in 7 normal children.	Arginine	99-107	growth hormone 1	Homo sapiens	25-39
2935541-4	1986	Both MEL cells and reticulocytes attached to the same site on fibronectin as do fibroblasts since adhesion of erythroid cells to fibronectin was specifically blocked by a monoclonal antibody directed against the cell-binding fragment of fibronectin and by a synthetic peptide containing the Arg-Gly-Asp-Ser sequence found in the cell-binding fragment of fibronectin.	Arginine	291-294	fibronectin 1	Homo sapiens	129-140
3086526-3	1986	After 10 days of reaction with alpha-dicarbonyls, the amino acid composition of lysozyme was markedly affected; i.e., 30-70% of lysine, 40-50% of tryptophan and 90% of arginine were lost respectively.	Arginine	168-176	lysozyme	Homo sapiens	80-88
3947350-3	1986	Synthetic peptides of apoE corresponding to residues 129-169, 139-169, and 144-169, but not 148-169, bound [125I] heparin suggesting that residues 144-147 (Leu-Arg-Lys-Arg) in E22 are important for binding.	Arginine	160-163	apolipoprotein E	Homo sapiens	22-26
3947350-3	1986	Synthetic peptides of apoE corresponding to residues 129-169, 139-169, and 144-169, but not 148-169, bound [125I] heparin suggesting that residues 144-147 (Leu-Arg-Lys-Arg) in E22 are important for binding.	Arginine	168-171	apolipoprotein E	Homo sapiens	22-26
3514020-1	1986	The peak levels of serum growth hormone (GH) obtained in response to administration of insulin and arginine in 26 children with constitutional delay in growth (CDG) are compared to similar test results in 7 normal children.	Arginine	99-107	growth hormone 1	Homo sapiens	41-43
2427462-0	1986	Sensory neuropeptides (substance P) and 4-11 SP enhance human neutrophils chemiluminescence; the role of L-arginine.	Arginine	105-115	tachykinin precursor 1	Homo sapiens	23-34
3024961-1	1986	Quantum mechanical simulations of the mechanism of action of superoxide dismutase (SOD) indicate that the presence of Arg-141 in the active site of the enzyme is responsible for the formation of an intermediate complex between superoxide and the enzyme in which the copper is not reduced.	Arginine	118-121	superoxide dismutase 1	Homo sapiens	61-81
3024961-1	1986	Quantum mechanical simulations of the mechanism of action of superoxide dismutase (SOD) indicate that the presence of Arg-141 in the active site of the enzyme is responsible for the formation of an intermediate complex between superoxide and the enzyme in which the copper is not reduced.	Arginine	118-121	superoxide dismutase 1	Homo sapiens	83-86
20493060-1	1986	Using specific antibodies to met-enkephalin, met-enkephalin-Arg(6)-Phe(7) and met-enkephalin-Arg(6)-Gly(7)-Leu(8), we have studied the distribution of these opioid peptides in the frog adrenal gland by means of the indirect immunofluorescence technique.	Arginine	60-63	proopiomelanocortin	Homo sapiens	45-59
20493060-9	1986	HPLC separation showed the presence of a peptide co-eluting with synthetic met-enkephalin-Arg(6)-Phe(7).	Arginine	90-93	proopiomelanocortin	Homo sapiens	75-89
3743871-2	1986	Reassociation experiments with chemically modified lysozymes indicate that positively charged amino acid residues of lysozyme (the epsilon-amino group of lysine and the guanidino group of arginine) are involved in the interaction with other proteins of the vitelline membrane.	Arginine	188-196	lysozyme	Homo sapiens	51-59
2438487-2	1986	ACE also has important arginine and tyrosine residues that are involved in substrate binding and a lysine that binds chloride.	Arginine	23-31	angiotensin I converting enzyme	Homo sapiens	0-3
3304396-0	1986	[Insulin secretion and utilization of insulin in piglets after insulin, arginine and glucose loads].	Arginine	72-80	insulin	Homo sapiens	1-8
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Arginine	352-360	arginine decarboxylase	Nicotiana tabacum	62-65
11539094-4	1986	Two kinds of evidence presented here support a major role for ADC in the generation of putrescine going into alkaloids:  (a) A specific "suicide inhibitor" of ADC effectively inhibits the biosynthesis of nicotine and nornicotine in tobacco callus, while the analogous inhibitor of ODC is less effective, and (b) the flow of 14C from uniformly labelled arginine into nicotine is much more efficient than that from ornithine.	Arginine	352-360	arginine decarboxylase	Nicotiana tabacum	159-162
20493060-1	1986	Using specific antibodies to met-enkephalin, met-enkephalin-Arg(6)-Phe(7) and met-enkephalin-Arg(6)-Gly(7)-Leu(8), we have studied the distribution of these opioid peptides in the frog adrenal gland by means of the indirect immunofluorescence technique.	Arginine	60-63	proopiomelanocortin	Homo sapiens	45-59
3877935-0	1985	The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.	Arginine	14-17	fibrinogen beta chain	Homo sapiens	49-59
4091829-4	1985	By contrast, modification of the arginine residues of plasma fibronectin resulted in a marked diminution of protein-fibroblast binding.	Arginine	33-41	fibronectin 1	Homo sapiens	61-72
4093448-5	1985	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequent fluorography for the products of prothrombin activation by staphylocoagulase in the presence of [3H]diisopropylphosphofluoridate (DFP) demonstrated the formation of a DFP-sensitive active site in the prothrombin molecule, and no cleavage of the Arg-Ile bond linking the A and B chains of alpha-thrombin was found.	Arginine	318-321	coagulation factor II, thrombin	Homo sapiens	106-117
4093448-5	1985	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequent fluorography for the products of prothrombin activation by staphylocoagulase in the presence of [3H]diisopropylphosphofluoridate (DFP) demonstrated the formation of a DFP-sensitive active site in the prothrombin molecule, and no cleavage of the Arg-Ile bond linking the A and B chains of alpha-thrombin was found.	Arginine	318-321	coagulation factor II, thrombin	Homo sapiens	109-117
3877935-1	1985	The Arg-Gly-Asp sequence resides in the cell attachment region of fibronectin.	Arginine	4-7	fibronectin 1	Homo sapiens	66-77
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Arginine	0-3	fibronectin 1	Homo sapiens	94-105
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Arginine	0-3	fibronectin 1	Homo sapiens	119-130
3877935-2	1985	Arg-Gly-Asp-containing peptides support fibroblast attachment, inhibit fibroblast adhesion to fibronectin, and inhibit fibronectin binding to thrombin-stimulated platelets.	Arginine	0-3	coagulation factor II, thrombin	Homo sapiens	142-150
4058253-6	1985	We have applied this HPLC-AECD methodology to quantitate ME, ME-Arg-Phe, ME-Arg-Gly-Leu and LE in pheochromocytoma tumors.	Arginine	64-67	proopiomelanocortin	Homo sapiens	61-63
2416502-1	1985	The endocrine pancreatic functions were evaluated in 19 patients with pancreatic head cancer by measuring plasma immunoreactive pancreatic glucagon (IRG) and insulin (IRI) responses to an intravenous dose of 30 g of arginine.	Arginine	216-224	insulin	Homo sapiens	158-171
3904455-3	1985	In the amniotic fluid obtained after arginine challenge in diabetic pregnant women, C peptide concentration was correlated with both insulin concentration (r = 0.61) and birth weight (r = 0.53).	Arginine	37-45	insulin	Homo sapiens	133-140
3904455-6	1985	Finally insulin and C peptide concentrations in the amniotic fluid obtained after arginine challenge in diabetic pregnant women showed a correlation with maternal metabolic control but not with the degree (White classification) of maternal diabetes.	Arginine	82-90	insulin	Homo sapiens	8-15
4091848-1	1985	Evidence is presented that the hypoglycemic action of the human growth hormone fragment, Ile-Pro-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala (hGH 4-15) is due to the interaction of hGH 4-15 with plasma membrane resulting in a time- and temperature-dependent release of a cellular mediator which acts to increase insulin binding and hexose transport with consequent potentiation of insulin action.	Arginine	105-108	growth hormone 1	Homo sapiens	64-78
2864239-3	1985	Perifusion studies measured nonstimulated and glucose- and arginine-stimulated insulin release from the three islet tissues.	Arginine	59-67	insulin	Homo sapiens	79-86
2864239-8	1985	Glucose (5.5-30 mM) and L-arginine (5-20 mM) elicited first phase insulin responses from single islet cells that were not significantly different from those observed with intact islets; in contrast, second phase responses of single islets to glucose were approximately 50% those seen with intact islets, and their second phase responses to arginine were absent.	Arginine	26-34	insulin	Homo sapiens	66-73
2864239-8	1985	Glucose (5.5-30 mM) and L-arginine (5-20 mM) elicited first phase insulin responses from single islet cells that were not significantly different from those observed with intact islets; in contrast, second phase responses of single islets to glucose were approximately 50% those seen with intact islets, and their second phase responses to arginine were absent.	Arginine	24-34	insulin	Homo sapiens	66-73
2864239-10	1985	Reaggregation of single islet cells was associated with markedly increased first and second phase insulin responses to both glucose and arginine stimulation.	Arginine	136-144	insulin	Homo sapiens	98-105
4055729-6	1985	The sequence determined for the flavin-peptide from sarcosine dehydrogenase contained 14 amino acid residues Leu-Thr-Ser-Gly-Thr-Thr-Trp-His(flavin)-Thr-Ala-Gly-Leu-Gly-Arg.	Arginine	169-172	sarcosine dehydrogenase	Rattus norvegicus	52-75
2867029-2	1985	Partial nucleotide sequence analysis of the coding region showed that it has only a single nucleotide difference from the Thy-1.2 gene, namely that amino acid 89 reads CGA (Arg) in Thy-1.1 and CAA (Glu) in Thy-1.2, corresponding to the amino acid substitutions previously identified.	Arginine	173-176	thymus cell antigen 1, theta	Mus musculus	122-129
2867029-2	1985	Partial nucleotide sequence analysis of the coding region showed that it has only a single nucleotide difference from the Thy-1.2 gene, namely that amino acid 89 reads CGA (Arg) in Thy-1.1 and CAA (Glu) in Thy-1.2, corresponding to the amino acid substitutions previously identified.	Arginine	173-176	thymus cell antigen 1, theta	Mus musculus	181-188
2995350-4	1985	Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen.	Arginine	34-37	fibronectin 1	Homo sapiens	96-107
2995350-4	1985	Moreover, the amino acid sequence Arg-Gly-Asp-Ser, corresponding to the cell attachment site of fibronectin, is located near the carboxyl-terminal region of the alpha-chain of fibrinogen.	Arginine	34-37	fibrinogen beta chain	Homo sapiens	176-186
2414098-7	1985	An Arg-Gly-Asp sequence, which has previously been shown to be the cell attachment site in fibronectin, was found in vitronectin immediately after the NH2-terminal somatomedin B sequence.	Arginine	3-6	fibronectin 1	Homo sapiens	91-102
3876125-4	1985	The smallest peptide from the cell-binding region of fibronectin which retained full activity was arg-gly-asp-ser.	Arginine	98-101	fibronectin 1	Homo sapiens	53-64
3876125-6	1985	Peptides containing the arg-gly-asp-ser sequence were also capable of inhibiting the adhesion of platelets to fibrinogen and von Willebrand factor substrates.	Arginine	24-27	fibrinogen beta chain	Homo sapiens	110-120
2863141-5	1985	All selected polypeptides have one single major cleavage site and both Arg-Xaa and Lys-Xaa bonds were found to be selectively cleaved by alpha-thrombin.	Arginine	71-74	coagulation factor II, thrombin	Homo sapiens	143-151
3934020-3	1985	An increase in insulin release was observed when microencapsulated islets were stimulated by glucose+theophylline, and when microencapsulated RINm5F cells were stimulated by arginine+theophylline.	Arginine	174-182	insulin	Homo sapiens	15-22
2864688-10	1985	The tetrapeptide sequence of Arg-Gly-Asp-Ser, which mediates the cell attachment and platelet binding activity of fibronectin, was also identified in the carboxyl-terminal portion of von Willebrand factor.	Arginine	29-32	fibronectin 1	Homo sapiens	114-125
2864688-10	1985	The tetrapeptide sequence of Arg-Gly-Asp-Ser, which mediates the cell attachment and platelet binding activity of fibronectin, was also identified in the carboxyl-terminal portion of von Willebrand factor.	Arginine	29-32	von Willebrand factor	Homo sapiens	183-204
4040873-5	1985	TK-I and TK-II can phosphorylate the synthetic peptide Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly (as well as its derivative with Orn in place of Arg), angiotensin II and poly(Glu, Tyr) 4:1 which exhibits different km values with TK-I and TK-II, (100 and 10 microM, respectively).	Arginine	79-82	angiotensinogen	Rattus norvegicus	149-163
2412224-0	1985	A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.	Arginine	80-88	fibronectin 1	Homo sapiens	142-153
2412224-5	1985	In contrast, liposomes containing a previously identified 140-kDa fibronectin receptor, which interacts with the Arg-Gly-Asp sequence in fibronectin, did not bind to vitronectin.	Arginine	113-116	fibronectin 1	Homo sapiens	66-77
2412224-5	1985	In contrast, liposomes containing a previously identified 140-kDa fibronectin receptor, which interacts with the Arg-Gly-Asp sequence in fibronectin, did not bind to vitronectin.	Arginine	113-116	fibronectin 1	Homo sapiens	137-148
2991265-8	1985	Both lung and brain ACE cleave Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (substance P) via two pathways.	Arginine	31-34	angiotensin I converting enzyme	Rattus norvegicus	20-23
2862561-2	1985	Somatostatin release induced by 19 mM arginine in the presence of 11 mM glucose or 10(-6)M glucagon in the presence of 5.5 mM glucose was suppressed by vagal stimulation.	Arginine	38-46	somatostatin	Rattus norvegicus	0-12
2862561-3	1985	This suppressive effect on somatostatin was eliminated in the presence of 10(-5)M atropine plus glucagon, while somatostatin release was significantly enhanced in the presence of atropine plus arginine.	Arginine	193-201	somatostatin	Rattus norvegicus	112-124
3160809-0	1985	Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser.	Arginine	66-69	fibronectin 1	Homo sapiens	0-11
2873008-3	1985	As a result of investigations of insulin and glucagon responses to glucose or arginine in vivo and in vitro using isolated islets obtained by the collagenase procedure, a decreased insulin response and paradoxical glucagon response to glucose, and an excessive glucagon response to arginine were found in the diabetic animals.	Arginine	78-86	insulin	Cricetulus griseus	33-40
3874235-4	1985	Of interest in this comparison is that both hFPA and hFPB are amino terminal peptides on the A and B chain of fibrinogen, respectively, and are readily cleaved by thrombin during fibrin formation and by other trypsin-like enzymes, leaving a carboxyl terminal Arg.	Arginine	259-262	fibrinogen beta chain	Homo sapiens	110-120
3874235-4	1985	Of interest in this comparison is that both hFPA and hFPB are amino terminal peptides on the A and B chain of fibrinogen, respectively, and are readily cleaved by thrombin during fibrin formation and by other trypsin-like enzymes, leaving a carboxyl terminal Arg.	Arginine	259-262	coagulation factor II, thrombin	Homo sapiens	163-171
3874206-0	1985	Specific modification of the functional arginine residue in soybean trypsin inhibitor (Kunitz) by peptidylarginine deiminase.	Arginine	40-48	kunitz trypsin protease inhibitor	Glycine max	68-124
2861079-2	1985	The influence of perfusate calcium, potassium, arginine, and glucose on release of somatostatin (SS) was measured using an isolated, perfused dog ileum preparation.	Arginine	47-55	somatostatin	Canis lupus familiaris	83-95
2992465-5	1985	A critical role of an Arg residue in ACE and, to a lesser extent, in "enkephalinase" (but not in thermolysin) is suggested to be responsible for the preferential dipeptidylcarboxypeptidase activity of these two enzymes.	Arginine	22-25	angiotensin I converting enzyme	Homo sapiens	37-40
4037298-6	1985	Human erythrocyte acetylcholinesterase contained two N-terminal amino acids with stoichiometries of 0.66 Glu and 0.34 Arg per 70-kDa subunit.	Arginine	118-121	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
2861079-5	1985	The addition of arginine (10 mM) elicited a prominent rise in SS secretion (from 105 +/- 8 pg/ml to 184 +/- 30 pg/ml; 2 P less than 0.05) while enhancement in glucose from 5-20 mM was without effect (57 +/- 13 pg/ml vs. 57 +/- 14 pg/ml).	Arginine	16-24	somatostatin	Canis lupus familiaris	62-64
3902521-14	1985	On the other hand, lower responses of blood glucose, insulin, glucagon and growth hormone to arginine were observed in subjects with hyperthyroidism than in the controls.	Arginine	93-101	insulin	Homo sapiens	53-60
4019786-7	1985	Furthermore, it indicates that arginine at 65 is essential for the conversion of proinsulin to insulin.	Arginine	31-39	insulin	Homo sapiens	81-91
4019786-7	1985	Furthermore, it indicates that arginine at 65 is essential for the conversion of proinsulin to insulin.	Arginine	31-39	insulin	Homo sapiens	84-91
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Arginine	158-161	proopiomelanocortin	Bos taurus	67-87
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Arginine	193-196	proopiomelanocortin	Bos taurus	67-87
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Arginine	193-196	proopiomelanocortin	Bos taurus	217-237
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Arginine	193-196	proopiomelanocortin	Bos taurus	67-87
2987247-7	1985	NH2- and COOH-terminal analysis of the products indicated that the pro-opiomelanocortin converting enzyme cleaves the peptide bond either between the Lys and Arg or on the carboxyl side of the Arg at Lys-Arg pairs of pro-opiomelanocortin.	Arginine	193-196	proopiomelanocortin	Bos taurus	217-237
3902521-14	1985	On the other hand, lower responses of blood glucose, insulin, glucagon and growth hormone to arginine were observed in subjects with hyperthyroidism than in the controls.	Arginine	93-101	growth hormone 1	Homo sapiens	75-89
3891467-2	1985	Plasma C-peptide responses to glucose and to arginine in the diabetic subjects were both significantly reduced at all glucose concentrations studied (P less than 0.01-0.005).	Arginine	45-53	insulin	Homo sapiens	7-16
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Arginine	289-297	HDL3	Homo sapiens	244-248
2985590-4	1985	Our results and the results from the literature search suggest that the aminopeptidase cleaves amino-terminal methionine when it precedes residues of alanine, glycine, proline, serine, threonine, and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine glutamic acid, isoleucine, leucine, lysine, or methionine.	Arginine	244-252	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
3996323-3	1985	In the presence of PTH (44 ng/ml) and when the ambient calcium concentration was 9.0 mg/dl, arginine (168 mg/dl)-induced glucagon secretion was augmented.	Arginine	92-100	parathyroid hormone	Rattus norvegicus	19-22
3922972-10	1985	At the codon for amino acid residue 112, the apo-E gene contained CGC, specifying Arg, whereas the cDNA contained TGC, specifying Cys.	Arginine	82-85	apolipoprotein E	Homo sapiens	45-50
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Arginine	289-297	HDL3	Homo sapiens	255-259
2986587-7	1985	Assuming a single receptor model, we found that 2.9 x 10(15) receptors/mg membrane protein bound with an affinity KD = 3.5 x 10(-7) M at 0 to 4 degrees C and KD = 1.9 x 10(-7) M at 37 degrees C. The binding was effectively competed with intact HDL3, with HDL3 that had undergone selective arginine and lysine residue modification, and with antibodies to apolipoproteins A-I and A-II.	Arginine	289-297	apolipoprotein A1	Homo sapiens	354-382
3998120-0	1985	Aminopeptidase activity in arginine-utilizing Mycoplasma spp.	Arginine	27-35	carboxypeptidase Q	Homo sapiens	0-14
3886433-8	1985	Evidence for arginine in the regulation of NAG synthesis is not as clear as for NAG on carbamoyl phosphate synthetase I.	Arginine	13-21	N-acetyl-alpha-glucosaminidase	Homo sapiens	43-46
3884753-5	1985	This review discusses the influence of dietary arginine on insulin secretion, glucose tolerance and repletion of lean body mass in animals.	Arginine	47-55	insulin	Homo sapiens	59-66
3884709-9	1985	These results indicate that leukocyte chemotactic and polarization responses to C5a and C5a des Arg vary, depending on the target cell type.	Arginine	96-99	complement C5a receptor 1	Homo sapiens	88-91
2992119-2	1985	Arginine infusion elicited increases in plasma insulin and glucagon in 6 patients with liver cell carcinoma as well as 8 patients with liver cirrhosis compared with the controls.	Arginine	0-8	insulin	Homo sapiens	47-54
3980461-10	1985	These data suggest that the Arg-Gly-Asp-Ser tetrapeptide contains a recognition specificity involved in the binding of Fn to platelets and that platelets share features of this recognition specificity with fibroblasts.	Arginine	28-31	fibronectin 1	Homo sapiens	119-121
3884709-0	1985	Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg.	Arginine	109-112	complement C5a receptor 1	Homo sapiens	101-104
3884709-1	1985	We examined responses of human peripheral blood polymorphonuclear leukocytes (PMN) and monocytes to the highly purified human complement-derived peptides C5a and C5a des Arg.	Arginine	170-173	complement C5a receptor 1	Homo sapiens	162-165
3884709-2	1985	As reported previously, C5a proved to be approximately 10- to 20-fold more potent than C5a des Arg as a chemoattractant for human PMN.	Arginine	95-98	complement C5a receptor 1	Homo sapiens	87-90
3980461-5	1985	Of the smaller peptides studied from this sequence, all peptides containing the Arg-Gly-Asp-Ser sequence, including the tetrapeptide itself, were active in inhibiting Fn binding to platelets (ID50 values approximately 10-20 microM).	Arginine	80-83	fibronectin 1	Homo sapiens	167-169
3980461-9	1985	In addition, Arg-Gly-Asp-Ser-containing peptides inhibited the rate and extent of thrombin-induced platelet aggregation.	Arginine	13-16	coagulation factor II, thrombin	Homo sapiens	82-90
2982683-5	1985	1984; 246:E405-11), is an index of the ability of hyperglycemia to potentiate the insulin response to arginine and as such is a measure of beta-cell responsiveness to glucose.	Arginine	102-110	insulin	Homo sapiens	82-89
3155608-3	1985	The rise in C3b receptor number was ascribed to up-regulation by C3a and C5a des Arg from complement activation and also, in the cases where sepsis occurred, to the presence of bacterial chemotactic peptides.	Arginine	81-84	complement C5a receptor 1	Homo sapiens	73-76
2936500-0	1985	[Hb J Camaguey [alpha 141 (HC3) Arg-Gly]--the first case identified in China].	Arginine	32-35	CYCS pseudogene 24	Homo sapiens	27-30
3890484-0	1985	Leucocytes activated by C5a des Arg promote endothelial prostacyclin (PGI2) production via release of oxygen species in vitro.	Arginine	32-35	complement C5a receptor 1	Homo sapiens	24-27
3916937-1	1985	Methylated lysine, arginine and histidine residues are found in a number of proteins (for example, histones, non-histone chromosomal proteins, ribosomal proteins, calmodulin, cytochrome C, etc.).	Arginine	19-27	cytochrome c, somatic	Homo sapiens	175-187
3925116-0	1985	Binding of 2-(4"-hydroxyphenylazo) benzoic acid with arginine, lysine, tyrosine and tryptophan modified bovine serum albumin.	Arginine	53-61	albumin	Homo sapiens	111-124
2981722-4	1985	N-terminal sequence analysis of peptide CP2bRA4SP9 established that C1r activation involves the cleavage of a single Arg-Ile bond, located in the sequence: ... Gln-Arg-Gln-Arg-Ile-Ile-Gly-Gly ... .	Arginine	117-120	complement C1r	Homo sapiens	68-71
3898762-3	1985	Maximal glycemic potentiation of the acute insulin response to IV arginine occurs at a glucose level of approx.	Arginine	66-74	insulin	Homo sapiens	43-50
3898762-8	1985	Similarly, insulin responses to nonglucose stimuli such as arginine often appear normal in NIDDM because of potentiation by hyperglycemia.	Arginine	59-67	insulin	Homo sapiens	11-18
3898762-9	1985	However, insulin responses to arginine are lower than those of nondiabetic controls when compared at multiple matched glucose levels.	Arginine	30-38	insulin	Homo sapiens	9-16
3898762-10	1985	Indeed, maximal potentiation by glucose of the insulin response to arginine is markedly subnormal in NIDDM, suggesting a loss of functional B cell secretory capacity.	Arginine	67-75	insulin	Homo sapiens	47-54
3909766-6	1985	Impaired plasma growth-hormone responses to insulin and arginine were more common and impaired plasma thyrotropin responses to TRH were less common in the Werner syndrome patients than in aged subjects.	Arginine	56-64	growth hormone 1	Homo sapiens	16-30
2878649-0	1985	Selective inhibitory effect of the analog D5-F-TrP8-D-Cys14 somatostatin on the arginine induced release of insulin, growth hormone and glucagon, in normal human beings.	Arginine	80-88	insulin	Homo sapiens	108-115
2878649-0	1985	Selective inhibitory effect of the analog D5-F-TrP8-D-Cys14 somatostatin on the arginine induced release of insulin, growth hormone and glucagon, in normal human beings.	Arginine	80-88	growth hormone 1	Homo sapiens	117-131
2579066-4	1985	The sequence obtained further predicted an arginine-rich sequence (RPRR) immediately upstream of the N-terminal threonine of C5a, indicating that the promolecule form of C5 is synthesized with a beta alpha-chain orientation as previously shown for pro-C3 and pro-C4.	Arginine	43-51	complement C5a receptor 1	Homo sapiens	125-128
3913601-0	1985	[Effect of smoking on the secretion of immunoreactive insulin (IRI) induced by the administration of L-arginine or glucagon].	Arginine	101-111	insulin	Homo sapiens	54-61
3155652-2	1985	A large cell-attachment-promoting fibronectin fragment was used as the affinity matrix, and specific elution was effected by using synthetic peptides containing the sequence Arg-Gly-Asp, which is derived from the cell recognition sequence in the fibronectin cell attachment site.	Arginine	174-177	fibronectin 1	Homo sapiens	246-257
3913581-1	1985	The nerve growth factor dimer (beta NGF) can undergo two proteolytic modifications, one near the amino terminus where a unique histidine/methionine bond is cleaved and the other at the carboxy terminus releasing the terminal arginine residue.	Arginine	225-233	nerve growth factor	Homo sapiens	31-39
3880560-5	1985	We also evaluated beta-cell responsiveness independently by measuring the plasma insulin response to arginine injections at three levels of glycemia and calculated potentiation slope from the relationship between the acute insulin response to arginine and the prestimulus glucose level.	Arginine	101-109	insulin	Homo sapiens	81-88
3937827-0	1985	Hb Tacoma [beta 30(B12) Arg----Ser], a slightly unstable hemoglobin variant found in Japan.	Arginine	24-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
2409028-11	1985	Using high performance liquid chromatography we have separated bradykinin from kallidin, des-Arg9-bradykinin (the degradation product of carboxypeptidase N) as well as the fragments Arg-Pro-Pro-Gly-Phe, Ser-Pro, and Phe-Arg, the degradation products formed by angiotensin-converting enzyme.	Arginine	93-96	kininogen 1	Homo sapiens	63-73
3897015-0	1985	Growth hormone responses to sleep, insulin hypoglycaemia and arginine infusion.	Arginine	61-69	growth hormone 1	Homo sapiens	0-14
3880560-5	1985	We also evaluated beta-cell responsiveness independently by measuring the plasma insulin response to arginine injections at three levels of glycemia and calculated potentiation slope from the relationship between the acute insulin response to arginine and the prestimulus glucose level.	Arginine	243-251	insulin	Homo sapiens	223-230
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	angiotensin I converting enzyme	Homo sapiens	37-40
3883047-2	1985	Considering this fact glucagon and insulin responses to oral glucose and intravenous arginine were studied in 22 CF children and adolescents.	Arginine	85-93	insulin	Homo sapiens	35-42
3883047-13	1985	Quantitative diminution in arginine stimulated insulin-output has been found to be independent of the degree of carbohydrate intolerance.	Arginine	27-35	insulin	Homo sapiens	47-54
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	tachykinin precursor 1	Homo sapiens	102-104
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	kininogen 1	Homo sapiens	106-116
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	tachykinin precursor 1	Homo sapiens	210-212
4089188-0	1985	Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine.	Arginine	85-93	prolactin	Homo sapiens	30-39
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	171-179	angiotensin I converting enzyme	Homo sapiens	37-40
2417254-5	1985	Modification of arginine residues in ACE with cylcohexanedione or butanedione inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	171-179	tachykinin precursor 1	Homo sapiens	102-104
6511917-4	1984	Using three different chemotactic stimuli, N-formylmethionylleucylphenylalanine, lymphocyte-derived chemotactic factor, and C5a des Arg, we studied the chemotactic responses of monocytes from seven homosexual men with AIDS, three homosexuals with lymphadenopathy and an abnormal immunological profile, seven healthy homosexual men, and 23 heterosexual control individuals.	Arginine	132-135	complement C5a receptor 1	Homo sapiens	124-127
6501302-5	1984	The results indicate that DARPP-32 is phosphorylated at a single threonine residue contained in the sequence Arg-Arg-Arg-Pro-Thr(P)-Pro-Ala-Met-Leu-Phe-Arg.	Arginine	109-112	protein phosphatase 1 regulatory inhibitor subunit 1B	Homo sapiens	26-34
6501302-5	1984	The results indicate that DARPP-32 is phosphorylated at a single threonine residue contained in the sequence Arg-Arg-Arg-Pro-Thr(P)-Pro-Ala-Met-Leu-Phe-Arg.	Arginine	113-116	protein phosphatase 1 regulatory inhibitor subunit 1B	Homo sapiens	26-34
6501302-5	1984	The results indicate that DARPP-32 is phosphorylated at a single threonine residue contained in the sequence Arg-Arg-Arg-Pro-Thr(P)-Pro-Ala-Met-Leu-Phe-Arg.	Arginine	113-116	protein phosphatase 1 regulatory inhibitor subunit 1B	Homo sapiens	26-34
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Arginine	85-93	insulin	Homo sapiens	36-46
6389572-2	1984	When the conversion of radiolabeled proinsulin to insulin was inhibited by replacing arginine and lysine with the aminoacid analogs, canavanine and thialysine, the nonconverted radioactive material remained associated with Golgi-derived, coated secretory granules.	Arginine	85-93	insulin	Homo sapiens	39-46
6532933-0	1984	The effect of acute hypercalcaemia on arginine induced growth hormone release in diabetic man.	Arginine	38-46	growth hormone 1	Homo sapiens	55-69
6532933-3	1984	Mild hypercalcaemia significantly diminished the GH response to arginine in patients with secondary diabetes, but not in those with ID.	Arginine	64-72	growth hormone 1	Homo sapiens	49-51
6497161-2	1984	Levels of C3a des Arg and C5a des Arg were elevated in 35 and 38 patients, respectively, and in all 25 with positive blood cultures.	Arginine	34-37	complement C5a receptor 1	Homo sapiens	26-29
6497161-3	1984	Highest C5a des Arg levels occurred in patients with hypotension (less than 90 mmHg) and/or acidemia.	Arginine	16-19	complement C5a receptor 1	Homo sapiens	8-11
6497161-4	1984	The C5a des Arg concentrations were significantly higher in patients with than in those without neutrophil-chemotactic activity.	Arginine	12-15	complement C5a receptor 1	Homo sapiens	4-7
6208326-3	1984	Serine-115 of MBP, in the sequence (-Arg-Phe-Ser(115)-Trp-), was found to be a preferred and probably major phosphorylation site for PL-Ca-PK.	Arginine	37-40	myelin basic protein	Bos taurus	14-17
6394628-0	1984	Arginine infusion stimulates prolactin, growth hormone, insulin, and subsequent lactation in pregnant dairy cows.	Arginine	0-8	prolactin	Bos taurus	29-38
6394628-7	1984	Therefore, repeated arginine infusion in late-pregnant cows dramatically increased prolactin, growth hormone, and insulin and tended to increase subsequent milk yield.	Arginine	20-28	prolactin	Bos taurus	83-92
6093114-3	1984	The proteolytic cleavage/activation site of F, to yield F2 and F1, contains five arginine residues.	Arginine	81-89	coagulation factor II, thrombin	Homo sapiens	56-65
6495993-2	1984	Met-enkephalin-Arg-Gly-Leu-like immunoreactivity (-LI) and Met-enkephalin-Arg-Phe-LI existed together with Met-enkephalin-LI and Leu-enkephalin-LI in 16 phaeochromocytomas.	Arginine	15-18	proopiomelanocortin	Homo sapiens	0-14
6495993-7	1984	These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.	Arginine	90-93	proopiomelanocortin	Homo sapiens	75-89
6495993-7	1984	These results indicate the co-existence of Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Gly-Leu and Met-enkephalin-Arg-Phe in human phaeochromocytomas, suggesting the preservation of amino acid sequences of these four opioid peptides even in neoplastic tissues.	Arginine	90-93	proopiomelanocortin	Homo sapiens	75-89
6207064-2	1984	Two HPI-specific mouse Mabs (GS-4G9 and GS-9A8) reacted with the same antigenic determinant, GS, which was localized to the site of linkage of the B-chain to the C-peptide (Arg-Arg) at positions 31-32.	Arginine	173-176	insulin	Homo sapiens	162-171
6499961-9	1984	Further, decreased activities of argininosuccinate synthetase and argininosuccinase together with increased arginase activity could lead to the depletion of arginine in senile cataracts.	Arginine	157-165	argininosuccinate synthase 1	Bos taurus	33-61
6392056-0	1984	The possible role of calmodulin in the arginine-induced glucagon release.	Arginine	39-47	calmodulin 1	Homo sapiens	21-31
6490722-3	1984	Fibroblast adhesion to fibronectin is competitively inhibited by certain synthetic peptides, including the decapeptide Arg-Gly-Asp-Ser-Pro-Ala-Ser-Ser-Lys-Pro, which appears to contain the cell recognition sequence.	Arginine	119-122	fibronectin 1	Homo sapiens	23-34
6490722-6	1984	Negative controls included another conserved fibronectin peptide from the collagen-binding region containing the sequence Cys-Gln-Asp-Ser-Glu-Thr-Arg-Thr-Phe-Tyr and another peptide.	Arginine	146-149	fibronectin 1	Homo sapiens	45-56
6501563-1	1984	Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.	Arginine	86-89	complement C5a receptor 1	Homo sapiens	78-81
6501563-6	1984	Purified C5a and C5a des arg were essentially equal in their ability to enhance neutrophil adherence, in contrast to the previously described greater in vitro potency of C5a compared with C5a des arg in stimulating neutrophil chemotaxis and enzyme release.	Arginine	25-28	complement C5a receptor 1	Homo sapiens	17-20
6501563-6	1984	Purified C5a and C5a des arg were essentially equal in their ability to enhance neutrophil adherence, in contrast to the previously described greater in vitro potency of C5a compared with C5a des arg in stimulating neutrophil chemotaxis and enzyme release.	Arginine	25-28	complement C5a receptor 1	Homo sapiens	17-20
6501563-6	1984	Purified C5a and C5a des arg were essentially equal in their ability to enhance neutrophil adherence, in contrast to the previously described greater in vitro potency of C5a compared with C5a des arg in stimulating neutrophil chemotaxis and enzyme release.	Arginine	25-28	complement C5a receptor 1	Homo sapiens	17-20
6238316-3	1984	Insulin responses to arginine was reduced in both groups, whereas glucagon response was increased in group C and reduced in group S. Plasma concentrations of branched-chain amino acids were reduced in both groups, irrespective of the degree of hyperinsulinism.	Arginine	21-29	insulin	Homo sapiens	0-7
6085034-0	1984	Synthesis of substance P analogs with arginine in position eleven.	Arginine	38-46	tachykinin precursor 1	Homo sapiens	13-24
6238619-8	1984	(1980) Biochemistry 19, 2343] that the A alpha and B beta chains behave independently in their competition for thrombin; i.e., the hydrolyzable Arg-Gly bonds of the A alpha and B beta chains are both accessible to thrombin.	Arginine	144-147	coagulation factor II, thrombin	Homo sapiens	111-119
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Arginine	43-46	fibronectin 1	Homo sapiens	182-193
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Arginine	43-46	fibronectin 1	Homo sapiens	309-320
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Arginine	111-114	fibronectin 1	Homo sapiens	182-193
6237366-5	1984	Assay of peptides containing the structure Arg-Gly-Asp-X (where X = another amino acid residue) showed that an Arg-Gly-Asp-Val sequence predicted to be present in some, but not all, fibronectin molecules as a result of alternative RNA splicings could potentially create a second cell attachment site in those fibronectin polypeptide chains carrying that sequence.	Arginine	111-114	fibronectin 1	Homo sapiens	309-320
6237366-8	1984	The result presented here show that the arginine, glycine, and aspartic acid residues are absolutely required for the cell recognition, and that the surrounding amino acids may play a role in the expression of cell attachment activity in fibronectin and other proteins having this sequence.	Arginine	40-48	fibronectin 1	Homo sapiens	238-249
6089896-6	1984	We have also demonstrated, using whole intestinal mucosal cells, that lysine and arginine-modified HDL3 inhibited binding of normal 125I-labeled HDL3 to the same extent as normal excess HDL3.	Arginine	81-89	HDL3	Homo sapiens	99-103
6089896-6	1984	We have also demonstrated, using whole intestinal mucosal cells, that lysine and arginine-modified HDL3 inhibited binding of normal 125I-labeled HDL3 to the same extent as normal excess HDL3.	Arginine	81-89	HDL3	Homo sapiens	145-149
6384269-2	1984	The acute insulin response to 5 g intravenous arginine was measured at five matched plasma glucose levels that ranged from approximately 100-615 mg/dl.	Arginine	46-54	insulin	Homo sapiens	10-17
6384269-5	1984	Insulin responses to arginine were lower in diabetics than in controls at all matched glucose levels (P less than 0.001 at all levels).	Arginine	21-29	insulin	Homo sapiens	0-7
6237366-1	1984	A tetrapeptide sequence, Arg-Gly-Asp-Ser, is the minimal structure recognized by cells in the large, adhesive glycoprotein fibronectin.	Arginine	25-28	fibronectin 1	Homo sapiens	123-134
6089896-6	1984	We have also demonstrated, using whole intestinal mucosal cells, that lysine and arginine-modified HDL3 inhibited binding of normal 125I-labeled HDL3 to the same extent as normal excess HDL3.	Arginine	81-89	HDL3	Homo sapiens	145-149
6381002-5	1984	The arginine-induced increase in plasma glucagon and C-peptide concentrations correlated significantly with urinary PABA excretion in chronic pancreatitis (P less than 0.001, P less than 0.01, respectively).	Arginine	4-12	insulin	Homo sapiens	53-62
6091745-3	1984	Phosvitin contains a core region of 99 amino acids, consisting of 80 serines, grouped in runs of maximally 14 residues interspersed by arginines, lysines, and asparagines.	Arginine	135-144	Casein kinase II subunit beta	Gallus gallus	0-9
6149574-6	1984	Examination of the amino acid sequences of C4a, and comparison with those of the homologous molecules C3a and C5a, shows that there is a marked difference in the distribution of basic residues near the C-terminal arginine residue which is the site of action of C1s.	Arginine	213-221	complement C5a receptor 1	Homo sapiens	110-113
6148165-7	1984	A temporal relationship was observed between the SRIF, insulin and glucagon responses following arginine infusion, while the GH levels increased only after the SRIF levels had declined, indicating an inhibition of GH.	Arginine	96-104	insulin	Homo sapiens	55-62
6746865-0	1984	Cholinergic mediation of growth hormone secretion elicited by arginine, clonidine, and physical exercise in man.	Arginine	62-70	growth hormone 1	Homo sapiens	25-39
6429132-8	1984	The following unique NH2-terminal amino acid sequence of the purified PSF was obtained: NH2ALA -SER-Ile-Ser-X-X-Asp-Thr-His-Arg-Leu-Thr-Arg-.	Arginine	124-127	interleukin 3	Mus musculus	70-73
6236212-2	1984	Edman degradation of six different preparations revealed the amino-terminal sequence of thrombospondin (TSP) to be Asn-Arg-Ile-Pro-Glu-Ser-Gly-Gly-Asp-Asn-Ser-Val-Phe-.	Arginine	119-122	thrombospondin 1	Homo sapiens	88-102
6236212-2	1984	Edman degradation of six different preparations revealed the amino-terminal sequence of thrombospondin (TSP) to be Asn-Arg-Ile-Pro-Glu-Ser-Gly-Gly-Asp-Asn-Ser-Val-Phe-.	Arginine	119-122	thrombospondin 1	Homo sapiens	104-107
6381061-6	1984	Postoperatively there was a significant correlation between peak insulin levels following arginine infusion and growth velocity in all patients.	Arginine	90-98	insulin	Homo sapiens	65-72
6329312-1	1984	Chemical modification of lysine or arginine residues of apolipoprotein B-100 in human low-density lipoprotein (LDL) with respectively reductive methylation (Me-LDL) or cyclohexanedione treatment (CHD-LDL) was applied to determine the role of these amino acids in LDL recognition by the various liver cell types.	Arginine	35-43	apolipoprotein B	Homo sapiens	56-76
6088878-3	1984	For maximum nonadherence, the optimum concentration was about 2 X 10(-11) M LTB4, 10(-9) M C5a des arg, 2 X 10(-8) M FMLP, 2 X 10(-9) M PAF, and 2 X 10(-8) M PMA.	Arginine	99-102	complement C5a receptor 1	Homo sapiens	91-94
6088878-9	1984	A competitive inhibitor of leukotriene slow-reacting substance of anaphylaxis, FPL 55712, blocked in a dose-response fashion LTB4-, C5a des arg-, and FMLP-triggered LAI.	Arginine	140-143	complement C5a receptor 1	Homo sapiens	132-135
6088878-10	1984	Eicosatetraenoic acid and nordihydroguaiaretic acid, cyclo-oxygenase-lipoxygenase pathway inhibitors, also markedly antagonized LTB4-, C5a des arg-, and FMLP-triggered LAI.	Arginine	143-146	complement C5a receptor 1	Homo sapiens	135-138
6088878-11	1984	Indomethacin (10(-5) M), piroxicam (10(-6) M), and aspirin, cyclooxygenase antagonists, negated LTB4-, C5a des arg-, and FMLP-induced LAI.	Arginine	111-114	complement C5a receptor 1	Homo sapiens	103-106
6088878-11	1984	Indomethacin (10(-5) M), piroxicam (10(-6) M), and aspirin, cyclooxygenase antagonists, negated LTB4-, C5a des arg-, and FMLP-induced LAI.	Arginine	111-114	formyl peptide receptor 1	Homo sapiens	121-125
6474412-1	1984	An assay for thrombin is presented wherein thrombin-catalyzed hydrolysis at Arg-A alpha-16 to release fibrinopeptide A (FPA) from fibrinogen is measured using high-performance liquid chromatography (HPLC).	Arginine	76-79	coagulation factor II, thrombin	Homo sapiens	13-21
6474412-1	1984	An assay for thrombin is presented wherein thrombin-catalyzed hydrolysis at Arg-A alpha-16 to release fibrinopeptide A (FPA) from fibrinogen is measured using high-performance liquid chromatography (HPLC).	Arginine	76-79	coagulation factor II, thrombin	Homo sapiens	43-51
6474412-1	1984	An assay for thrombin is presented wherein thrombin-catalyzed hydrolysis at Arg-A alpha-16 to release fibrinopeptide A (FPA) from fibrinogen is measured using high-performance liquid chromatography (HPLC).	Arginine	76-79	fibrinogen beta chain	Homo sapiens	130-140
6745415-4	1984	The sequence of human GIP is thus: (Formula: see text) Amino acid residues 18 and 34 are Arg and Ser, respectively, in porcine GIP.	Arginine	89-92	gastric inhibitory polypeptide	Homo sapiens	22-25
6745415-4	1984	The sequence of human GIP is thus: (Formula: see text) Amino acid residues 18 and 34 are Arg and Ser, respectively, in porcine GIP.	Arginine	89-92	gastric inhibitory polypeptide	Homo sapiens	127-130
6429132-8	1984	The following unique NH2-terminal amino acid sequence of the purified PSF was obtained: NH2ALA -SER-Ile-Ser-X-X-Asp-Thr-His-Arg-Leu-Thr-Arg-.	Arginine	136-139	interleukin 3	Mus musculus	70-73
6373920-9	1984	C5a des arg partially inhibited the binding of Fl-C5a to neutrophils, but was 1000-fold less effective than C5a.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
6208535-8	1984	Modification of arginine residues in ACE with cyclohexanedione or butanedione similarly inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	181-189	angiotensin I converting enzyme	Homo sapiens	37-40
6208535-8	1984	Modification of arginine residues in ACE with cyclohexanedione or butanedione similarly inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	angiotensin I converting enzyme	Homo sapiens	37-40
6208535-8	1984	Modification of arginine residues in ACE with cyclohexanedione or butanedione similarly inhibited hydrolysis of SP, bradykinin and Bz-Gly-Phe-Arg (80-93%) indicating an active site arginine is required for hydrolysis of SP.	Arginine	16-24	kininogen 1	Homo sapiens	116-126
6539375-5	1984	Both parents were heterozygous for the hGH-N gene deletion and had a low hGH response to arginine and L-dopa tolerance tests, but had normal basal somatomedin-C levels and normal somatomedin-C generation tests.	Arginine	89-97	growth hormone 1	Homo sapiens	39-44
6373920-9	1984	C5a des arg partially inhibited the binding of Fl-C5a to neutrophils, but was 1000-fold less effective than C5a.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	50-53
6373920-9	1984	C5a des arg partially inhibited the binding of Fl-C5a to neutrophils, but was 1000-fold less effective than C5a.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	50-53
6463563-0	1984	Testosterone treatment and arginine-induced growth hormone stimulation in male delayed puberty: effects on serum calcium, phosphate and vitamin D metabolites.	Arginine	27-35	growth hormone 1	Homo sapiens	44-58
6463563-1	1984	Hormonal changes after arginine-induced growth hormone stimulation and subsequent testosterone treatment were examined in 5 patients classified as having male delayed puberty.	Arginine	23-31	growth hormone 1	Homo sapiens	40-54
6144033-2	1984	Insulin and somatostatin levels rose significantly compared to those in lean littermate controls during arginine infusion.	Arginine	104-112	somatostatin	Rattus norvegicus	12-24
6730854-1	1984	The effect of [1-(beta-mercapto-beta, beta- cyclopentamethylene -propionic acid),2-0- ethyltyrosine ,4-valine]-arginine vasopressin on the water metabolism was studied in rats.	Arginine	110-119	arginine vasopressin	Rattus norvegicus	120-131
6547060-7	1984	The kinetics of phosphorylation of shortened peptides corresponding to this 18-residue sequence together with those of another related sequence, RPQRAKAKTTKATSNVFS , indicated that the myosin light chain kinase had a relatively stronger dependence on lysine residues, whereas the cAMP-dependent protein kinase depends more on arginine residues.	Arginine	326-334	myosin light chain kinase	Gallus gallus	185-210
6326579-3	1984	On a molar basis the amount of C5a des Arg calculated to be in our preparation of ZAP was found to be up to approximately 80 times more potent than LTB4, although in vitro the two chemotaxins have been reported to be about equipotent.	Arginine	39-42	complement C5a receptor 1	Homo sapiens	31-34
6326579-4	1984	ZAP is more representative of what may happen in vivo than its principal constituent C5a des Arg, but for a more precise comparison the purified and isolated peptide will have to be compared with synthetic LTB4.	Arginine	93-96	complement C5a receptor 1	Homo sapiens	85-88
6443592-7	1984	The two residues at the C-terminus of E3, Lys-Arg, are removed during or shortly after cleavage from PE2.	Arginine	46-49	ETS2 repressor factor	Homo sapiens	101-104
6609366-4	1984	In transformed NIH 3T3 mouse fibroblast cells labeled with [35S]methionine, the ratio of pp21 to p21 was strikingly modulated by the amino acid at residue 12. v-Ha-ras p21 has an arginine at position 12, and 24% of total p21 was in the phosphorylated form.	Arginine	179-187	transcription elongation factor A (SII)-like 1	Mus musculus	89-93
6609366-4	1984	In transformed NIH 3T3 mouse fibroblast cells labeled with [35S]methionine, the ratio of pp21 to p21 was strikingly modulated by the amino acid at residue 12. v-Ha-ras p21 has an arginine at position 12, and 24% of total p21 was in the phosphorylated form.	Arginine	179-187	transcription elongation factor A (SII)-like 1	Mus musculus	90-93
6711579-3	1984	Deficient secretion of growth hormone was documented during multiple arginine-insulin tolerance tests, and gonadotropin levels were low.	Arginine	69-77	growth hormone 1	Homo sapiens	23-37
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Arginine	129-132	calmodulin 1	Homo sapiens	40-50
6722127-1	1984	Tryptic fragmentation of Ca2+-saturated calmodulin (CaM) takes place mainly at Lys-77; however, proteolysis can occur instead at Arg-74 or Lys-75.	Arginine	129-132	calmodulin 1	Homo sapiens	52-55
6709646-2	1984	The enzyme also catalyzes the cleavage of arginine from des-[Arg9]-bradykinin and the hydrolysis of several X-proline dipeptides including L-arginyl-L-proline, L-leucyl-L-proline, and L-alanyl-L-proline.	Arginine	42-50	kininogen 1	Homo sapiens	67-77
6370761-0	1984	Time-dependent inhibition of insulin release: suppression of the arginine effect by hyperglycaemia.	Arginine	65-73	insulin	Homo sapiens	29-36
6203623-5	1984	Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp).	Arginine	105-108	proopiomelanocortin	Homo sapiens	78-81
6203623-5	1984	Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp).	Arginine	105-108	proopiomelanocortin	Homo sapiens	82-86
6142577-6	1984	SS-28 completely inhibited the arginine-stimulated insulin increase while SS-14 only partially inhibited the insulin increase.	Arginine	31-39	insulin	Homo sapiens	51-58
6142577-7	1984	Since insulin opposes the increase in serum potassium by stimulating cellular uptake of this cation, the enhanced rise in serum potassium in response to arginine hydrochloride during the SS-28 infusion is likely due to the potent insulin suppressing effect of SS-28.	Arginine	153-175	insulin	Homo sapiens	230-237
6140160-5	1984	The perfusate somatostatin response to arginine also was exaggerated in the VMH-lesioned rats.	Arginine	39-47	somatostatin	Rattus norvegicus	14-26
6370761-1	1984	Brief stimulation of the pancreas with arginine causes a refractory state which reduces the insulin response to subsequent stimulations (time-dependent inhibition).	Arginine	39-47	insulin	Homo sapiens	92-99
6370761-2	1984	In control subjects, a pair of arginine injections (75 mg/kg) at a 30-min interval resulted in 20% reduction of peak and integrated insulin responses to the second injection.	Arginine	31-39	insulin	Homo sapiens	132-139
6370761-3	1984	In Type 2 (non-insulin-dependent) diabetic patients and in obese subjects, the inhibitory effect of repeated arginine stimuli was abolished.	Arginine	109-117	insulin	Homo sapiens	15-22
6370761-5	1984	This induced a three- to fivefold greater insulin response to arginine.	Arginine	62-70	insulin	Homo sapiens	42-49
6370761-7	1984	When the arginine stimulation was repeated 30 min later, no inhibition was observed, the second insulin response being instead augmented 1.5- to 1.8-fold.	Arginine	9-17	insulin	Homo sapiens	96-103
6428892-2	1984	Growth hormone secretion responded to glucagon-propranolol and showed a good response to arginine.	Arginine	89-97	growth hormone 1	Homo sapiens	0-14
6428892-4	1984	After the oral administration of arginine hydrochloride, growth hormone showed a good response to insulin and glucagon-propranolol, and gain in height and weight accelerated.	Arginine	33-55	growth hormone 1	Homo sapiens	57-71
6144197-5	1984	Plasma insulin concentrations in response to oral glucose tolerance test and arginine infusion were markedly low.	Arginine	77-85	insulin	Homo sapiens	7-14
6524712-6	1984	By homology with the sequence of human serum transferrin (MacGillivray et al., 1982) the Lys:Arg and Asp:Gly substitutions probably occur at residues 527 and 446, respectively, from the N-terminus.	Arginine	93-96	transferrin	Homo sapiens	45-56
6146518-0	1984	Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin, GH and glucagon in normal men.	Arginine	53-61	insulin	Homo sapiens	81-88
6437213-2	1984	The purified enzyme cleaved arginine from des-(Arg9)-bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe) had a molecular weight in nondenaturing buffers of 155,000 +/- 6,900 daltons, was not inactivated by chelating agents, had a pH optimum of 7.2, and was stimulated by manganous ions.	Arginine	28-36	kininogen 1	Homo sapiens	53-63
6437213-4	1984	Extensively washed and intact human erythrocytes cleaved arginine from exogenously supplied des-(Arg9)-bradykinin; arginine was the earliest-appearing reaction product.	Arginine	57-65	kininogen 1	Homo sapiens	103-113
6437213-4	1984	Extensively washed and intact human erythrocytes cleaved arginine from exogenously supplied des-(Arg9)-bradykinin; arginine was the earliest-appearing reaction product.	Arginine	115-123	kininogen 1	Homo sapiens	103-113
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	23-26	T4t004	Escherichia phage T4	18-22
6714935-11	1984	Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine.	Arginine	146-154	carboxypeptidase Q	Homo sapiens	0-14
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	152-155	T4t004	Escherichia phage T4	18-22
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	177-180	insulin	Homo sapiens	146-156
6661434-4	1983	Furthermore, the time course of release, in relation to that of fibrinopeptide A, suggested that some des-A-fibrinogen species (e.g., alpha 2B beta 2 gamma 2) may be the true activator for promoting the cleavage of the Arg-36 peptide bonds in the a subunits of factor XIII.	Arginine	219-222	fibrinogen beta chain	Homo sapiens	108-118
6362661-9	1983	The typical serine proteinase active-site residues are clearly conserved in C1s, and the specificity-related side chain of the substrate-binding pocket is aspartic acid, as in trypsin, consistent with the proteolytic action of C1s on C4 at an arginine residue.	Arginine	243-251	complement C1s	Homo sapiens	227-230
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	177-180	insulin	Homo sapiens	149-156
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	183-186	insulin	Homo sapiens	146-156
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	183-186	insulin	Homo sapiens	149-156
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	183-186	insulin	Homo sapiens	146-156
6196183-6	1983	This structure could not be regenerated by mixing equimolar amounts of human insulin and C-peptide, including the chemically synthesized complete proinsulin connecting segment (Arg X Arg X HCP X Lys X Arg), which contains the entire sequence removed from proinsulin in the conversion to mature insulin.	Arginine	183-186	insulin	Homo sapiens	149-156
6664356-3	1983	Growth-hormone (GH) was measured after i.v.-Arginine-provocationtest; in 7 cases GH-peaks did not rise over 10 ng/ml, 4 of the children showed GH-peaks of less than 4 ng/ml.	Arginine	44-52	growth hormone 1	Homo sapiens	0-14
6324142-2	1983	Analysis of tryptic digests of these reptile beta-endorphins by paper electrophoresis at pH 3.5 and gel filtration on a Sephadex G-15 column indicated that there are two tyrosine residues, two arginine residues and one methionine residue in reptile beta-endorphin.	Arginine	193-201	proopiomelanocortin	Homo sapiens	45-59
6556144-2	1983	Bradykinin is destroyed by two enzymes: a plasma carboxypeptidase (anaphylatoxin inactivator) removes the COOH-terminal arginine to yield an inactive octapeptide, and a dipeptidase (identical to the angiotensin-converting enzyme) removes the COOH-terminal Phe-Arg to yield a fragment of seven amino acids that is further fragmented to an end product of five amino acids.	Arginine	120-128	kininogen 1	Homo sapiens	0-10
6418218-0	1983	Importance of arginine residues in the determination of the biological activity of human corticosteroid-binding globulin.	Arginine	14-22	serpin family A member 6	Homo sapiens	89-120
6356742-2	1983	Growth hormone, insulin and glucose levels after arginine administration were significantly higher before parathyroidectomy compared with the corresponding data obtained in the post-operative state, whereas plasma prolactin concentrations did not differ before and after operation.	Arginine	49-57	growth hormone 1	Homo sapiens	0-14
6648427-5	1983	It is therefore concluded that fibrinogen Bern II undergoes substitution of arginine in position 16 of the A alpha-chain by histidine.	Arginine	76-84	fibrinogen beta chain	Homo sapiens	31-41
6418218-1	1983	The binding activity of human corticosteroid-binding globulin (CBG) is pH dependent and governed in alkaline pH ranges by the pK of arginine.	Arginine	132-140	serpin family A member 6	Homo sapiens	30-61
6418218-1	1983	The binding activity of human corticosteroid-binding globulin (CBG) is pH dependent and governed in alkaline pH ranges by the pK of arginine.	Arginine	132-140	serpin family A member 6	Homo sapiens	63-66
6418218-5	1983	Therefore the surprising stability of CBG up to pH 11.5 may be explained by a large dependence of the CBG tertiary structure on the integrity of one arginine residue : as long as the ionized state of this single residue is not changed (pH less than pK of the guanidyl group) the tertiary structure of the biologically active CBG is maintained in alkaline pH ranges.	Arginine	149-157	serpin family A member 6	Homo sapiens	38-41
6642786-3	1983	Arginine infusion test (for GH and PRL response) was performed only in ASA-treated subjects.	Arginine	0-8	growth hormone 1	Homo sapiens	28-30
6642786-4	1983	Arginine-induced GH and PRL release was abolished and enhanced, respectively, by ASA pre-treatment.	Arginine	0-8	growth hormone 1	Homo sapiens	17-19
6684664-3	1983	Here we show that incubation of chicken embryo erythroid cells in a medium in which arginine has been substituted by its amino acid analogue, canavanine, results in the inhibition of the posttranslational assembly of vimentin into the TX-100-insoluble filaments.	Arginine	84-92	vimentin	Gallus gallus	217-225
6361008-5	1983	The specificity constant (kcat/Km) for the hydrolysis of PTA-GPA by trypsin was about 4 times larger than that of PTA-Arg.	Arginine	118-121	glycophorin A (MNS blood group)	Homo sapiens	61-64
6361008-7	1983	However, PTA derivatives of GPA and Arg were hydrolyzed with kcat/Km values smaller than those of N alpha-benzoyl ethyl esters of L-GPA and L-Arg by factors of 4 and 17, respectively.	Arginine	36-39	glycophorin A (MNS blood group)	Homo sapiens	132-135
6361008-7	1983	However, PTA derivatives of GPA and Arg were hydrolyzed with kcat/Km values smaller than those of N alpha-benzoyl ethyl esters of L-GPA and L-Arg by factors of 4 and 17, respectively.	Arginine	140-145	glycophorin A (MNS blood group)	Homo sapiens	28-31
6684664-7	1983	These results suggest that arginine residues play an essential role in the assembly of vimentin in vivo.	Arginine	27-35	vimentin	Gallus gallus	87-95
6604220-6	1983	This finding indicates that the reactive center of alpha 1-antitrypsin is methionine 358, which acts as a bait for elastase, just as the normal reactive center of antithrombin III is arginine 393, which acts as a bait for thrombin.	Arginine	183-191	serpin family A member 1	Homo sapiens	51-70
6412234-3	1983	The Tangier isoprotein 2 was shown to correspond to pro-apo A-I, having a six-amino acid amino-terminal extension with the sequence: Arg-His-Phe-Trp-Gln-Gln-.	Arginine	133-136	apolipoprotein A1	Homo sapiens	56-63
6310515-2	1983	Our sequence shows that haptoglobin is very likely synthesized as a single polypeptide chain which is then cleaved at an Arg residue to generate its two characteristic alpha and beta subunit.	Arginine	121-124	haptoglobin	Homo sapiens	24-35
6354722-0	1983	The effect of glucose, tolbutamide, and arginine on C-peptide release during remission in type I diabetes mellitus.	Arginine	40-48	insulin	Homo sapiens	52-61
6193199-3	1983	The microELISA technique used in this study is specific for human C5a and C5a des arg (C5a antigen) but not for human C5.	Arginine	82-85	complement C5a receptor 1	Homo sapiens	74-77
6193199-3	1983	The microELISA technique used in this study is specific for human C5a and C5a des arg (C5a antigen) but not for human C5.	Arginine	82-85	complement C5a receptor 1	Homo sapiens	74-77
6225101-2	1983	Insulin secretion was investigated in 65 insulin-dependent diabetic patients by determining C peptide levels before and after stimulation with either an 800 calories test meal or an injection of glucagon or arginine i.v.	Arginine	207-215	insulin	Homo sapiens	0-7
6139329-0	1983	Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients.	Arginine	47-55	insulin	Homo sapiens	64-71
6139329-0	1983	Dissociated effects of somatostatin analogs on arginine-induced insulin, glucagon and growth hormone release in acromegalic patients.	Arginine	47-55	growth hormone 1	Homo sapiens	86-100
6354722-8	1983	arginine test determining the C-peptide response by calculating the area under the curve above baseline levels.	Arginine	0-8	insulin	Homo sapiens	30-39
6354722-13	1983	In contrast, C-peptide secretion during arginine infusion following i.v.	Arginine	40-48	insulin	Homo sapiens	13-22
6354722-15	1983	tolbutamide was significantly enhanced compared to the C-peptide secretion observed during arginine infusion alone.	Arginine	91-99	insulin	Homo sapiens	55-64
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Arginine	58-61	coagulation factor II, thrombin	Homo sapiens	81-89
6354722-19	1983	tolbutamide without themselves being an appropriate signal for C-peptide release amplify the response to a subsequent arginine infusion under appropriate conditions.	Arginine	118-126	insulin	Homo sapiens	63-72
6195896-5	1983	One of the complement protein fragments, C5a (with or without carboxyl terminal arginine which is necessary for histamine release), is very potent in increasing vascular permeability.	Arginine	80-88	complement C5a receptor 1	Homo sapiens	41-44
6349379-2	1983	Insulin release in vivo during a 15-min intravenous infusion of leucine (0.97 mM) or arginine (0.97 mM) with GIP (17 ng/min) was greater than with infusion of either amino acid or GIP alone.	Arginine	85-93	gastric inhibitory polypeptide	Rattus norvegicus	109-112
6657512-4	1983	Argo-Met-enkephalin was hydrolyzed by aminoenkephalinases to form Arg, Tyr, and Gly-Gly-Phe-Met in a substrate-inhibited manner.	Arginine	0-3	proopiomelanocortin	Homo sapiens	5-19
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Arginine	58-61	fibrinogen beta chain	Homo sapiens	249-259
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Arginine	58-61	S100 calcium binding protein A10	Homo sapiens	474-477
6136627-3	1983	Basal levels of growth hormone and of pancreatic and gastric hormones were reduced and the response of growth hormone, insulin and C-peptide to stimuli such as arginine, glucose, glibenclamide and calcium was virtually abolished.	Arginine	160-168	insulin	Homo sapiens	119-126
6346005-5	1983	After restoration of normocalcemia and normocalcemia and normophosphatemia we found significantly lower glucose and insulin levels following arginine infusion and a significantly increased hypoglycemic response to parenterally administered insulin, probably indicating partial improvement of glucose tolerance after surgery.	Arginine	141-149	insulin	Homo sapiens	116-123
6345197-6	1983	Of the functional positions known to be involved in substrate or inhibitor binding, Asp 97, Lys 143 and Arg 217 (Leu in TPA) may contribute to plasminogen activating specificity.	Arginine	104-107	plasminogen activator, tissue type	Homo sapiens	120-123
6684048-3	1983	Two of 4 patients undergoing arginine provocation testing had a partial response to tamoxifen and both exhibited marked diminution of growth hormone stimulation which was not seen in the non-responders.	Arginine	29-37	growth hormone 1	Homo sapiens	134-148
6414103-7	1983	It is concluded 1) that even in hypophysectomized normoprolactinemic patients the circulating PRL may originate mainly from the residual tumor cells, and 2) that the sulpiride test is useful to detect the abnormalities of hypothalamo-pituitary axis in operated patients with PRL-secreting adenomas, whereas TRH, arginine, and L-dopa tests are less useful for such purposes.	Arginine	312-320	prolactin	Homo sapiens	94-97
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Arginine	71-74	neurotensin	Homo sapiens	28-39
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Arginine	71-74	tachykinin precursor 1	Homo sapiens	44-55
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Arginine	75-78	neurotensin	Homo sapiens	28-39
6193076-0	1983	Conformational study of the neurotensin and substance P fragments: Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro.	Arginine	75-78	tachykinin precursor 1	Homo sapiens	44-55
6193076-1	1983	The conformational behaviour of the basic hydrophilic Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro peptides, neurotensin (NT) and Substance P fragments, has been taken up by semi-empirical calculations.	Arginine	58-61	neurotensin	Homo sapiens	100-111
6193076-1	1983	The conformational behaviour of the basic hydrophilic Pro-Arg-Arg-Pro and Arg-Pro-Lys-Pro peptides, neurotensin (NT) and Substance P fragments, has been taken up by semi-empirical calculations.	Arginine	58-61	tachykinin precursor 1	Homo sapiens	121-132
6405779-4	1983	An additional thrombin cleavage site in profragment 1 has been identified at arginine 54 by automated sequence analysis of thrombin digests by prothrombin.	Arginine	77-85	coagulation factor II, thrombin	Homo sapiens	14-22
6348222-9	1983	We conclude that insulin is an important mediator of arginine- and glucose-induced hypercalciuria in the rat.	Arginine	53-61	insulin	Homo sapiens	17-24
6409108-4	1983	The amino-terminal sequence of proapoA-I isolated from human lymph revealed the presence of 6 additional amino acids, Arg-His-Phe-Trp-Gln-Gln, on the amino-terminal end of apoA-I consistent with the proapoA-I sequence determined by nucleic acid sequence analysis of cloned apoA-I.	Arginine	118-121	apolipoprotein A1	Homo sapiens	34-40
6409108-4	1983	The amino-terminal sequence of proapoA-I isolated from human lymph revealed the presence of 6 additional amino acids, Arg-His-Phe-Trp-Gln-Gln, on the amino-terminal end of apoA-I consistent with the proapoA-I sequence determined by nucleic acid sequence analysis of cloned apoA-I.	Arginine	118-121	apolipoprotein A1	Homo sapiens	172-178
6405779-4	1983	An additional thrombin cleavage site in profragment 1 has been identified at arginine 54 by automated sequence analysis of thrombin digests by prothrombin.	Arginine	77-85	coagulation factor II, thrombin	Homo sapiens	123-131
6849832-0	1983	Fibrinogen Manchester: identification of an abnormal fibrinopeptide A with a C-terminal arginine leads to histidine substitution.	Arginine	88-96	fibrinogen beta chain	Homo sapiens	0-10
6349864-1	1983	The effect of acetyl-salicylic acid (ASA, 3 g/d for three days) on basal and arginine-stimulated concentrations of insulin and growth hormone was studied in seven type II diabetics.	Arginine	77-85	insulin	Homo sapiens	115-122
6349864-1	1983	The effect of acetyl-salicylic acid (ASA, 3 g/d for three days) on basal and arginine-stimulated concentrations of insulin and growth hormone was studied in seven type II diabetics.	Arginine	77-85	growth hormone 1	Homo sapiens	127-141
6846278-2	1983	Her growth hormone (GH) response to insulin-induced hypoglycemia and arginine infusion was blunted.	Arginine	69-77	growth hormone 1	Homo sapiens	4-18
6846278-2	1983	Her growth hormone (GH) response to insulin-induced hypoglycemia and arginine infusion was blunted.	Arginine	69-77	growth hormone 1	Homo sapiens	20-22
6354533-10	1983	Base sequencing of MSG renin cDNA indicated an Arg-Arg residue additional to the published amino acid sequence of the heavy chain.	Arginine	47-50	renin	Homo sapiens	23-28
6882831-2	1983	The action of thrombin on the esters, Tos-P2-Arg-OCH3 and Tos-P3-P2-Arg-OCH3, where P2 and P3 are the residues of L-, D- or N-methylamino acids, has been studied.	Arginine	45-48	coagulation factor II, thrombin	Homo sapiens	14-22
6853490-4	1983	A single nucleotide change in the codon for arginine 50 (CGA leads to GGA) could explain this substitution.	Arginine	44-52	chromogranin A	Homo sapiens	57-60
6408432-0	1983	[Inhibition of arginine-stimulated pancreatic glucagon secretion with biosynthetic human insulin and swine insulin in healthy subjects and diabetics].	Arginine	15-23	insulin	Homo sapiens	89-96
6347264-0	1983	[Function of the arginine residue in the active center of baker"s yeast transketolase].	Arginine	17-25	transketolase	Homo sapiens	72-85
6347264-1	1983	The binding of anionic and non-anionic donor substrates to baker"s yeast transketolase modified at the arginine residue by 2,3-butanedione was studied.	Arginine	103-111	transketolase	Homo sapiens	73-86
6354533-10	1983	Base sequencing of MSG renin cDNA indicated an Arg-Arg residue additional to the published amino acid sequence of the heavy chain.	Arginine	51-54	renin	Homo sapiens	23-28
6300236-4	1983	These smooth muscle cells also respond to purified human anaphylatoxin; exposure to the cells to purified human C5a or C5a des Arg produce contractions of the smooth muscle cells that are accompanied by increased Ca2+ influx.	Arginine	127-130	complement C5a receptor 1	Homo sapiens	119-122
6101263-1	1983	The protein kinase associated with the purified epidermal growth factor (EGF) receptor from membrane (Mr = 150,000) or vesicle (Mr = 170,000) preparations of A-431 cells was shown to catalyze the phosphorylation of the peptide Leu-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly at the tyrosine residue.	Arginine	259-262	epidermal growth factor receptor	Homo sapiens	48-86
6101263-1	1983	The protein kinase associated with the purified epidermal growth factor (EGF) receptor from membrane (Mr = 150,000) or vesicle (Mr = 170,000) preparations of A-431 cells was shown to catalyze the phosphorylation of the peptide Leu-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly at the tyrosine residue.	Arginine	263-266	epidermal growth factor receptor	Homo sapiens	48-86
6101263-1	1983	The protein kinase associated with the purified epidermal growth factor (EGF) receptor from membrane (Mr = 150,000) or vesicle (Mr = 170,000) preparations of A-431 cells was shown to catalyze the phosphorylation of the peptide Leu-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Arg-Arg-Gly at the tyrosine residue.	Arginine	263-266	epidermal growth factor receptor	Homo sapiens	48-86
6134651-8	1983	In comparison with control subjects, insulin release was normal in response to arginine and tolbutamide but was reduced in response to oral and intravenous glucose, while glucagon and growth hormone release were similar in both groups.	Arginine	79-87	insulin	Homo sapiens	37-44
6341118-1	1983	A synthetic amino-terminal fragment of human growth hormone (hGH) containing the sequence H2N-Leu-Ser-Arg-Leu-Phe-Asp-Asn-Ala-COOH (hGH 6-13) was shown to increase [125I]iodoinsulin binding to rat hepatic receptors in vivo.	Arginine	102-105	growth hormone 1	Homo sapiens	45-59
6340676-4	1983	The concordant results obtained and the inhibitory action of aprotinin observed in these experiments led us to conclude to the existence in plasma of a trypsin dependent C-peptidase with a specificity for the COOH terminus of the complete CPR (Arg - Arg - C-peptide - Lys - Arg).	Arginine	244-247	cytochrome p450 oxidoreductase	Homo sapiens	239-242
6340676-4	1983	The concordant results obtained and the inhibitory action of aprotinin observed in these experiments led us to conclude to the existence in plasma of a trypsin dependent C-peptidase with a specificity for the COOH terminus of the complete CPR (Arg - Arg - C-peptide - Lys - Arg).	Arginine	244-247	insulin	Homo sapiens	256-265
6340676-4	1983	The concordant results obtained and the inhibitory action of aprotinin observed in these experiments led us to conclude to the existence in plasma of a trypsin dependent C-peptidase with a specificity for the COOH terminus of the complete CPR (Arg - Arg - C-peptide - Lys - Arg).	Arginine	250-253	cytochrome p450 oxidoreductase	Homo sapiens	239-242
6340676-4	1983	The concordant results obtained and the inhibitory action of aprotinin observed in these experiments led us to conclude to the existence in plasma of a trypsin dependent C-peptidase with a specificity for the COOH terminus of the complete CPR (Arg - Arg - C-peptide - Lys - Arg).	Arginine	250-253	insulin	Homo sapiens	256-265
6687626-7	1983	As is the case for the bovine arginine-vasopressin-neurophysin II (AVP-NpII) precursor, the signal sequence of the OT-NpI precursor is immediately followed by the nonapeptide hormone which is connected to neurophysin I by a Gly-Lys-Arg sequence.	Arginine	232-235	oxytocin/neurophysin I prepropeptide	Bos taurus	115-121
6877243-2	1983	CRP binds with phosphocholine and phosphate esters; initiates reactions of agglutination, opsonization and complement consumption; and precipitates with protamine and synthetic polymers of lysine and arginine, and these reactivities are modulated by calcium and phosphocholine.	Arginine	200-208	C-reactive protein	Homo sapiens	0-3
6339205-15	1983	In conclusion, when given as a constant infusion in rats, both PHI and VIP exert a direct hypoglycemic effect and modulate the influence of glucose and arginine on insulin and glucagon secretion.	Arginine	152-160	vasoactive intestinal peptide	Rattus norvegicus	71-74
6600480-6	1983	The carboxyterminal arginine of C5a is not essential in order for C5a to enhance immune responses.	Arginine	20-28	complement C5a receptor 1	Homo sapiens	32-35
6405197-0	1983	Effect of chemical modification of arginine and lysine residues of fibronectin on its antigenic and gelatin-binding activity.	Arginine	35-43	fibronectin 1	Homo sapiens	67-78
6405197-1	1983	The effect of chemical modification of arginine and lysine residues of fibronectin on its antigenic and gelatin-binding activity was studied by enzyme immunoassay techniques.	Arginine	39-47	fibronectin 1	Homo sapiens	71-82
6405197-5	1983	The results suggest that arginine residues are directly involved in the binding of fibronectin to gelatin.	Arginine	25-33	fibronectin 1	Homo sapiens	83-94
6342632-0	1983	[Biphasic response of insulin secretion to arginine stimulation: daily changes].	Arginine	43-51	insulin	Homo sapiens	22-29
6303156-2	1983	Activity of purified catalytic subunit toward the synthetic peptide Leu-Arg-Arg-Ala-Ser-Leu-Gly (PK-1; Kemptide) was 1.5- to 45-fold greater than activity toward other commonly used substrates such as histone fractions, casein, and protamine.	Arginine	72-75	pyruvate kinase L/R	Homo sapiens	97-101
6338832-1	1983	The inhibition of thrombin by antithrombin-III involves formation of a 1:1 covalent complex between protease and inhibitor and concomitant cleavage of the antithrombin-III peptide chain after Arg-385.	Arginine	192-195	coagulation factor II, thrombin	Homo sapiens	18-26
6188072-4	1983	The C-terminal hexa- and octapeptides of neurotensin (Arg-Arg-Pro-Tyr-Ile-Leu and Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu, respectively) induced a non-cytolytic release of histamine with the latter peptide being more active (ED50 = 90 microM for the hexapeptide and 13 microM for the octapeptide).	Arginine	54-57	neurotensin	Homo sapiens	41-52
6338832-6	1983	The initial sites of proteolytic attack on the complex are after Arg-13 of the thrombin A chain and Arg-68 of the thrombin B chain.	Arginine	65-68	coagulation factor II, thrombin	Homo sapiens	79-87
6338832-6	1983	The initial sites of proteolytic attack on the complex are after Arg-13 of the thrombin A chain and Arg-68 of the thrombin B chain.	Arginine	100-103	coagulation factor II, thrombin	Homo sapiens	114-122
6600480-7	1983	C5ades Arg was found to augment the immune response to the level of C5a-mediated enhancement.	Arginine	7-10	complement C5a receptor 1	Homo sapiens	0-3
6403444-5	1983	The response of growth hormone to arginine, and irregular spikes in growth hormone concentrations following TRH seen in the euglycaemic state were suppressed during hyperglycaemia.	Arginine	34-42	growth hormone 1	Homo sapiens	16-30
6677247-2	1983	Plasma fibronectin was purified on gelatin-sepharose with 1 M arginine elution and iodinated with 125I by the solid phase glycoluril method.	Arginine	62-70	fibronectin 1	Homo sapiens	7-18
6403444-6	1983	The suppression of the arginine-induced release of growth hormone by hyperglycaemia was observed both with and without concomitant administration of exogenous insulin.	Arginine	23-31	growth hormone 1	Homo sapiens	51-65
6403444-7	1983	The rise in serum prolactin concentrations in response to arginine was unaffected by hyperglycaemia, whereas the TRH-induced release of prolactin was suppressed.	Arginine	58-66	prolactin	Homo sapiens	18-27
6403444-8	1983	Since arginine induces the release of growth hormone and prolactin via the hypothalamus, while TRH acts at the pituitary level, the glycaemic state appears to exert a modulatory effect on the secretion of growth hormone and prolactin in type II-diabetics at both locations.	Arginine	6-14	growth hormone 1	Homo sapiens	38-52
6403444-8	1983	Since arginine induces the release of growth hormone and prolactin via the hypothalamus, while TRH acts at the pituitary level, the glycaemic state appears to exert a modulatory effect on the secretion of growth hormone and prolactin in type II-diabetics at both locations.	Arginine	6-14	prolactin	Homo sapiens	57-66
6131858-0	1983	On the inhibitory effects of somatostatin on arginine-induced insulin and growth hormone secretion in man: influence of aminophylline.	Arginine	45-53	insulin	Homo sapiens	62-69
6848611-5	1983	These properties are identical with those of chemotactic C5-derived peptides (C5a and/or C5a des Arg).	Arginine	97-100	complement C5a receptor 1	Homo sapiens	89-92
6816799-2	1982	The protein was bound strongly to the arginine column and thus could be separated from fibronectin.	Arginine	38-46	fibronectin 1	Homo sapiens	87-98
6664256-6	1983	These results indicate the co-existence of met-enkephalin, leu-enkephalin, met-enkephalin-Arg-Phe, met-enkephalin-Arg-Gly-Leu and their high molecular weight forms derived from preproenkephalin A in human pheochromocytomas and suggest the association of preproenkephalin A synthesis with epinephrine production in human pheochromocytomas.	Arginine	90-93	proopiomelanocortin	Homo sapiens	75-89
6664256-6	1983	These results indicate the co-existence of met-enkephalin, leu-enkephalin, met-enkephalin-Arg-Phe, met-enkephalin-Arg-Gly-Leu and their high molecular weight forms derived from preproenkephalin A in human pheochromocytomas and suggest the association of preproenkephalin A synthesis with epinephrine production in human pheochromocytomas.	Arginine	90-93	proopiomelanocortin	Homo sapiens	75-89
6424106-2	1983	Aminopeptidase II1 preferred L-arginine- and L-lysine-beta-naphthylamides or p-nitroanilides as substrate, with low or negligible hydrolysis of other amino acid derivatives.	Arginine	29-39	carboxypeptidase Q	Homo sapiens	0-14
6763264-0	1982	[Insulin secretion induced by glucose or arginine in non-obese volunteers.	Arginine	41-49	insulin	Homo sapiens	1-8
7160472-0	1982	Interaction of fibronectin with arginine-agarose.	Arginine	32-40	fibronectin 1	Homo sapiens	15-26
7174788-1	1982	We have previously shown a marked difference in the inflammatory response to human C5a or C5a des arginine (Arg) instilled in rabbit lungs.	Arginine	108-111	complement C5a receptor 1	Homo sapiens	90-93
6818083-1	1982	Insulin secretion was monitored in monkey islets isolated by collagenase digestion and exposed to leucine and arginine with and without glucose.	Arginine	110-118	insulin	Homo sapiens	0-7
7174788-0	1982	In vivo clearance and tissue distribution of C5a and C5a des arginine complement fragments in rabbits.	Arginine	61-69	complement C5a receptor 1	Homo sapiens	53-56
7174788-4	1982	Although greater than 50% of the injected radioactivity was cleared from the circulation within 2 min for both mediators, C5a des Arg persisted in the circulation longer than C5a.	Arginine	130-133	complement C5a receptor 1	Homo sapiens	122-125
7174788-5	1982	C5a instillation caused an acute neutropenia, whereas C5a des Arg caused a less severe and more prolonged neutropenia, preceding a neutrophilic response observed with both mediators.	Arginine	62-65	complement C5a receptor 1	Homo sapiens	54-57
7174788-10	1982	These results indicate that C5a and C5a des Arg are rapidly removed from the circulation by specific accumulation in vascularized tissues.	Arginine	44-47	complement C5a receptor 1	Homo sapiens	36-39
7174788-12	1982	These experiments further suggest there are neutrophil-dependent and neutrophil-independent mechanisms involved in the removal of C5a and C5a des Arg from the circulation and that binding of C5 fragments in the pulmonary vasculature may precede and then induce neutrophil sequestration.	Arginine	146-149	complement C5a receptor 1	Homo sapiens	130-133
7174788-12	1982	These experiments further suggest there are neutrophil-dependent and neutrophil-independent mechanisms involved in the removal of C5a and C5a des Arg from the circulation and that binding of C5 fragments in the pulmonary vasculature may precede and then induce neutrophil sequestration.	Arginine	146-149	complement C5a receptor 1	Homo sapiens	138-141
6761899-8	1982	Following arginine infusion, plasma IRI and CPR increased in the normal subjects and the patients with moderate diabetes.	Arginine	10-18	cytochrome p450 oxidoreductase	Homo sapiens	44-47
7145556-4	1982	There was a significant increase in peak growth hormone response to arginine stimulation among subjects receiving methylphenidate therapy; however, this appeared to correlate with acute methylphenidate administration.	Arginine	68-76	growth hormone 1	Homo sapiens	41-55
7172090-8	1982	Specific chemical modification studies revealed that human apo E isomorphism is due, in part, to differences in arginine and cysteine residues but not to lysine residues.	Arginine	112-120	apolipoprotein E	Homo sapiens	59-64
7150549-3	1982	The rates of hydrolysis of the Arg-Gly bond in these peptides by thrombin were measured, and the rate for the Phe-containing peptide F-6 was found to be much larger than that for F-7.	Arginine	31-34	coagulation factor II, thrombin	Homo sapiens	65-73
6765550-3	1982	The delayed increments of glucagon under human insulin following arginine stimulation may be the result of a more rapid insulin absorption from subcutaneous tissue and a greater biologic action of this insulin in comparison with the PPI.	Arginine	65-73	insulin	Homo sapiens	47-54
6765550-3	1982	The delayed increments of glucagon under human insulin following arginine stimulation may be the result of a more rapid insulin absorption from subcutaneous tissue and a greater biologic action of this insulin in comparison with the PPI.	Arginine	65-73	insulin	Homo sapiens	120-127
6765550-3	1982	The delayed increments of glucagon under human insulin following arginine stimulation may be the result of a more rapid insulin absorption from subcutaneous tissue and a greater biologic action of this insulin in comparison with the PPI.	Arginine	65-73	insulin	Homo sapiens	120-127
6749882-2	1982	We have synthesized the 12 amino acid C-peptide region of IGF-I (Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Glu-Thr) and developed a RIA based on antibodies against this synthetic peptide.	Arginine	89-92	insulin like growth factor 1	Homo sapiens	58-63
6749882-2	1982	We have synthesized the 12 amino acid C-peptide region of IGF-I (Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Glu-Thr) and developed a RIA based on antibodies against this synthetic peptide.	Arginine	93-96	insulin like growth factor 1	Homo sapiens	58-63
6293985-0	1982	Beta-endorphin: synthesis and properties of analogs with replacement of lysine residues by arginine.	Arginine	91-99	proopiomelanocortin	Homo sapiens	0-14
6757593-0	1982	[Response of growth hormone (HGH) to L-dopa, L-arginine and their combination in normal individuals].	Arginine	45-55	growth hormone 1	Homo sapiens	13-27
7118924-1	1982	We have studied the effects of phenylglyoxal and other related arginine-specific reagents on the mammary cytoplasmic glucocorticoid receptor.	Arginine	63-71	nuclear receptor subfamily 3 group C member 1	Homo sapiens	117-140
7118924-5	1982	Thus, these studies suggest that arginine residues may be involved in the binding of glucocorticoids to mammary cytoplasmic glucocorticoid receptor.	Arginine	33-41	nuclear receptor subfamily 3 group C member 1	Homo sapiens	124-147
7151830-1	1982	Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism.	Arginine	35-43	prolactin	Homo sapiens	18-21
7151830-3	1982	Arginine infusion elicited significant (P less than 0.05) rises in plasma PRL in all groups.	Arginine	0-8	prolactin	Homo sapiens	74-77
7151830-4	1982	The maximal increment of plasma PRL above the baseline level after arginine stimulation was significantly larger (P less than 0.05) in pubertal than in prepubertal females and was significantly smaller (P less than 0.05) in patients with hyperthyroidism than in age- and sex-matched controls.	Arginine	67-75	prolactin	Homo sapiens	32-35
7151830-6	1982	These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children.	Arginine	24-32	prolactin	Homo sapiens	75-78
7151830-6	1982	These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children.	Arginine	24-32	prolactin	Homo sapiens	87-90
7151830-0	1982	Prolactin response to arginine in children with hyperthyroidism and primary hypothyroidism.	Arginine	22-30	prolactin	Homo sapiens	0-9
7151830-1	1982	Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism.	Arginine	35-43	prolactin	Homo sapiens	7-16
7151830-6	1982	These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children.	Arginine	103-111	prolactin	Homo sapiens	87-90
6752282-0	1982	Purification of human C5a des arg by immunoadsorbent and molecular sieve chromatography.	Arginine	30-33	complement C5a receptor 1	Homo sapiens	22-25
7151830-7	1982	Plasma PRL response to arginine is suppressed in children with hyperthyroidism and the basal plasma PRL is markedly elevated in primary hypothyroidism.	Arginine	23-31	prolactin	Homo sapiens	7-10
6213638-2	1982	The formation of the fibrinogen-thrombospondin complex was specific, saturable, and partially inhibited by mannosamine, glucosamine, and arginine.	Arginine	137-145	fibrinogen beta chain	Homo sapiens	21-31
6286669-5	1982	The site of insulin-directed phosphorylation of ATP-citrate lyase (Thr-Ala-Ser(32P)-Phe-Ser-Glu-Ser-Arg) is the same as that directed by glucagon, and, in turn, identical with that phosphorylated by the cAMP-dependent protein kinase in vitro.	Arginine	100-103	insulin	Homo sapiens	12-19
6752282-1	1982	Human C5a des arg was isolated from complement-activated serum by immunoadsorption followed by Sephadex G-75 chromatography.	Arginine	14-17	complement C5a receptor 1	Homo sapiens	6-9
6752282-2	1982	C5a des arg obtained by this 2-step procedure was shown to be immunologically identical to C5a des arg purified by a conventional multi-step method, homogeneous on SDS-polyacrylamide gels, and biologically active.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
6752282-2	1982	C5a des arg obtained by this 2-step procedure was shown to be immunologically identical to C5a des arg purified by a conventional multi-step method, homogeneous on SDS-polyacrylamide gels, and biologically active.	Arginine	99-102	complement C5a receptor 1	Homo sapiens	0-3
6752282-2	1982	C5a des arg obtained by this 2-step procedure was shown to be immunologically identical to C5a des arg purified by a conventional multi-step method, homogeneous on SDS-polyacrylamide gels, and biologically active.	Arginine	99-102	complement C5a receptor 1	Homo sapiens	91-94
6752282-3	1982	Although this technique yields approximately the same amount of C5a des arg/liter of activated serum as that obtained by conventional methods, its simplicity and relative rapidity make it a practical alternative.	Arginine	72-75	complement C5a receptor 1	Homo sapiens	64-67
6751896-0	1982	Insulin delivery rate in response to glucose and arginine infusion in hyperthyroidism.	Arginine	49-57	insulin	Homo sapiens	0-7
6751896-1	1982	Insulin delivery rates were estimated from the peripheral serum insulin response to a single bolus injection of glucose or arginine in eight normal subjects and eight patients with hyperthyroidism.	Arginine	123-131	insulin	Homo sapiens	0-7
6751896-1	1982	Insulin delivery rates were estimated from the peripheral serum insulin response to a single bolus injection of glucose or arginine in eight normal subjects and eight patients with hyperthyroidism.	Arginine	123-131	insulin	Homo sapiens	64-71
6751896-7	1982	Insulin delivery showed a monophasic pattern following arginine infusion in both patients and control subjects.	Arginine	55-63	insulin	Homo sapiens	0-7
7044143-0	1982	Interaction of arginine and gastric inhibitory polypeptide on insulin release in man.	Arginine	15-23	insulin	Homo sapiens	62-69
6180381-4	1982	Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1).	Arginine	92-95	interferon gamma	Homo sapiens	40-49
6180381-4	1982	Nucleotide sequence analysis of several IFN-gamma cDNA clones showed the presence of a CGA (Arg) codon at position 140 of mature IFN-gamma in contrast with the CAA (Gln) codon, which is found in p69 (1).	Arginine	92-95	interferon gamma	Homo sapiens	129-138
6180780-3	1982	The C-terminal heptapeptide and the dipeptide Arg-Pro negligibly inhibited ACE activity.	Arginine	46-49	angiotensin I converting enzyme	Homo sapiens	75-78
7045153-5	1982	In nine patients, arginine-stimulated acute insulin responses (AIR) were studied at each of three plasma glucose (PG) levels both before and during chlorpropamide treatment.	Arginine	18-26	insulin	Homo sapiens	44-51
6289314-3	1982	At sites A/B, apo-E2, -E3, and -E4 contain cysteine/cysteine, cysteine/arginine, and arginine/arginine, respectively.	Arginine	71-79	apolipoprotein E	Homo sapiens	14-34
6289314-3	1982	At sites A/B, apo-E2, -E3, and -E4 contain cysteine/cysteine, cysteine/arginine, and arginine/arginine, respectively.	Arginine	85-93	apolipoprotein E	Homo sapiens	14-34
6289314-3	1982	At sites A/B, apo-E2, -E3, and -E4 contain cysteine/cysteine, cysteine/arginine, and arginine/arginine, respectively.	Arginine	85-93	apolipoprotein E	Homo sapiens	14-34
6289314-4	1982	We demonstrated that the substitution of cysteine for arginine at site B is at least partly responsible for the defective binding of apo-E2 to human fibroblast low density lipoprotein receptors, compared to the normal binding activity of apo-E3 or -E4.	Arginine	54-62	apolipoprotein E	Homo sapiens	133-139
6289314-4	1982	We demonstrated that the substitution of cysteine for arginine at site B is at least partly responsible for the defective binding of apo-E2 to human fibroblast low density lipoprotein receptors, compared to the normal binding activity of apo-E3 or -E4.	Arginine	54-62	apolipoprotein E	Homo sapiens	238-244
6756004-3	1982	For glucagon, the increase was present at all times tested, for insulin this rise was significant only during the first 60 min of the arginine test and during the rapid secretory phase following glucose injection.	Arginine	134-142	insulin	Homo sapiens	64-71
7044143-4	1982	When the stimulatory effect of the secretagogue(s) alone on insulin (IRI) is computed, the increase due to OG (A) and to 7.5 g.m-2.h-1 Arg (D) were similar and additive (A + D approximately equal to E).	Arginine	135-138	insulin	Homo sapiens	60-67
7125955-2	1982	The present study demonstrates that growth hormone secretion stimulated by arginine is also inhibited by hemodialysis.	Arginine	75-83	growth hormone 1	Homo sapiens	36-50
7044143-6	1982	The 15 and 7.5 g.m-2.h-1 Arg infusion produced different patterns of insulin and glucagon secretions.	Arginine	25-28	insulin	Homo sapiens	69-76
6759231-3	1982	Insulin secretion in response to intravenous arginine and glucose was evaluated in S2H, S0H, and matched controls.	Arginine	45-53	insulin	Homo sapiens	0-7
6176283-2	1982	Anti-FBP sera varied in the extent to which they cross-reacted with fibrinogen, the NH2-terminal disulfide knot of fibrinogen (N-DSK), B beta 1(Pyr)-118(Met), B beta 1(Pyr)-42(Arg), and desarginyl-FPB.	Arginine	176-179	ECB2	Homo sapiens	5-8
7037370-13	1982	Higher doses of GIP significantly potentiated insulin release stimulated by glucose or arginine.	Arginine	87-95	gastric inhibitory polypeptide	Rattus norvegicus	16-19
6130017-8	1982	Various secretagogues such as IBMX, 8-bromo cyclic AMP, and L-arginine increased insulin, somatostatin, and glucagon secretory rates in an expected manner.	Arginine	60-70	somatostatin	Rattus norvegicus	90-102
7055587-0	1982	A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain.	Arginine	95-103	Fc gamma receptor and transporter	Homo sapiens	134-145
6811468-1	1982	A protected tridecapeptide of the sequence Boc-Lys(2CIZ)-Arg(Tos)-Leu-Glu (OcHex)-Trp(For)-Ile-Ala-Ala-Ser(Bzl)-Arg(Tos)-Asn-Lys(2CIZ)-Gly-OH, representing residues 43-55 of the variable region of the heavy chain of mouse myeloma protein M603, was synthesized.	Arginine	57-60	zinc finger protein 384	Mus musculus	52-55
6759231-4	1982	Intravenous arginine and glucose elicited an exaggerated acute phase of insulin secretion in S2H compared with controls when analyzed as incremental insulin area 0-10", peak level attained, and mean insulin levels postinjection.	Arginine	12-20	insulin	Homo sapiens	72-79
7067169-0	1982	Inhibition of arginine- and hypoglycemia- induced growth hormone release by acetate in dialyzed patients.	Arginine	14-22	growth hormone 1	Homo sapiens	50-64
7067169-2	1982	The present study was designed to clarify the potency and characteristics of the growth hormone suppressive effect of acetate by applying two powerful growth hormone stimuli: arginine infusion and insulin hypoglycemia.	Arginine	175-183	growth hormone 1	Homo sapiens	81-95
6759231-4	1982	Intravenous arginine and glucose elicited an exaggerated acute phase of insulin secretion in S2H compared with controls when analyzed as incremental insulin area 0-10", peak level attained, and mean insulin levels postinjection.	Arginine	12-20	insulin	Homo sapiens	149-156
7067169-3	1982	In four non-diabetic uremic and three diabetic uremic subjects, arginine infusion caused a rise in plasma growth hormone to 22.8 +/- 3.3 ng/ml and 22.0 +/- 5.6 ng/ml (mean +/- SEM, P less than 0.05).	Arginine	64-72	growth hormone 1	Homo sapiens	106-120
6759231-5	1982	Insulin responses to arginine and glucose in S0H and matched controls were identical.	Arginine	21-29	insulin	Homo sapiens	0-7
7090924-1	1982	Human eosinophil peroxidase is a cationic protein with a higher content of arginine, the enzyme being poorly soluble in water.	Arginine	75-83	eosinophil peroxidase	Homo sapiens	6-27
7094206-10	1982	After hydrolysis, the non-histones were found to contain a labeled lysine and arginine derivative, but in the histone fraction only labeled lysine was found.	Arginine	78-86	H2B clustered histone 1	Rattus norvegicus	26-33
7137951-1	1982	A 14-year-old girl and a 13-year-old boy were found to be growth hormone deficient by insulin-arginine stimulation tests, and were also found to be zinc deficient.	Arginine	94-102	growth hormone 1	Homo sapiens	58-72
7137951-1	1982	A 14-year-old girl and a 13-year-old boy were found to be growth hormone deficient by insulin-arginine stimulation tests, and were also found to be zinc deficient.	Arginine	94-102	insulin	Homo sapiens	86-93
6127053-3	1982	Saturation constants (Ks) of P17 with acetate, arginine, aspartate, glutamate, lactate, succinate, malonate, p-hydroxybenzoate and glucose were all below 1 microM.	Arginine	47-55	family with sequence similarity 72 member B	Homo sapiens	29-32
7100893-1	1982	The present paper describes the structural analysis of an abnormal hemoglobin variant of alpha-chain found in a Chinese woman in the Hechi district of the Zhuang Autonomous Region of Guangxi, and finds it to be hemoglobin Handsworth (alpha 18(A16) Gly leads to Arg).	Arginine	261-264	Fc gamma receptor and transporter	Homo sapiens	89-100
7068434-0	1982	Hemoglobin Kawachi [alpha 44 (CE2) Pro leads to Arg]: a new hemoglobin variant of high oxygen affinity with amino acid substitution at alpha 1 beta 2 contact.	Arginine	48-51	carboxylesterase 2	Homo sapiens	30-33
7117668-0	1982	Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage.	Arginine	103-111	coagulation factor II, thrombin	Homo sapiens	14-22
7117668-0	1982	Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage.	Arginine	103-111	fibrinogen beta chain	Homo sapiens	35-45
7117668-0	1982	Inhibition of thrombin cleavage of fibrinogen by polyestradiol phosphate; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage.	Arginine	103-111	fibrinogen beta chain	Homo sapiens	124-134
6764509-5	1982	Serum immunoreactive insulin concentrations increased in response to eating and arginine, but hGH did not alter the insulin secretory response to either stimulus.	Arginine	80-88	insulin	Homo sapiens	21-28
6170701-0	1981	Human C5a des Arg increases vascular permeability.	Arginine	14-17	complement C5a receptor 1	Homo sapiens	6-9
7037487-2	1981	The present study was aimed at investigating the effect of metergoline, a powerful and long-lasting antiserotoninergic agent, on insulin responses to glucose and arginine in adult-onset diabetic subjects.	Arginine	162-170	insulin	Homo sapiens	129-136
7044895-1	1981	A gene has been constructed which codes for an analog of human proinsulin in which the normal 35-amino acid connecting peptide is replaced by a "mini-C" peptide of six amino acids (Arg-Arg-Gly-Ser-Lys-Arg).	Arginine	181-184	insulin	Homo sapiens	63-73
7044895-1	1981	A gene has been constructed which codes for an analog of human proinsulin in which the normal 35-amino acid connecting peptide is replaced by a "mini-C" peptide of six amino acids (Arg-Arg-Gly-Ser-Lys-Arg).	Arginine	185-188	insulin	Homo sapiens	63-73
7044895-1	1981	A gene has been constructed which codes for an analog of human proinsulin in which the normal 35-amino acid connecting peptide is replaced by a "mini-C" peptide of six amino acids (Arg-Arg-Gly-Ser-Lys-Arg).	Arginine	185-188	insulin	Homo sapiens	63-73
6170701-2	1981	The carboxypeptidase inhibitor was added to prevent cleavage of the carboxyl terminal arginine from C5a and enabled it to be purified on the basis of spasmogenic activity on the guinea-pig isolated ileum.	Arginine	86-94	complement C5a receptor 1	Homo sapiens	100-103
6170701-6	1981	The observation that both human C5a and C5a des Arg were able to increase vascular permeability in vivo suggested a parallel with leukotactic activity in vitro.	Arginine	48-51	complement C5a receptor 1	Homo sapiens	40-43
7040494-9	1981	Insulin levels with arginine infusion were significantly increased, and growth hormone levels decreased with bumetanide but not with furosemide.	Arginine	20-28	insulin	Homo sapiens	0-7
7334949-4	1981	Thus, two molecules of neurotensin placed head to tail can form a Kusnetsov-Ghokov grid with four cross-links (p glu and glu to arg - arg) x 2.	Arginine	128-131	neurotensin	Homo sapiens	23-34
7334949-4	1981	Thus, two molecules of neurotensin placed head to tail can form a Kusnetsov-Ghokov grid with four cross-links (p glu and glu to arg - arg) x 2.	Arginine	134-137	neurotensin	Homo sapiens	23-34
6117495-2	1981	To investigate this, the effect of D-glyceraldehyde, dihydroxyacetone, D-mannoheptulose and glucose variations during arginine stimulation on the release of somatostatin and glucagon from the isolated pancreas of normal and streptozotocin diabetic dogs was studied.	Arginine	118-126	somatostatin	Canis lupus familiaris	157-169
6117495-9	1981	In both the diabetic and the normal animals, arginine (5 mmol/l) stimulated somatostatin and glucagon secretion.	Arginine	45-53	somatostatin	Canis lupus familiaris	76-88
6790534-5	1981	Rat alpha-1-antitrypsin showed significant differences in amino acid composition when compared to human alpha-1-antitrypsin, particularly in lysine, glutamic acid, arginine, methionine, and tyrosine content.	Arginine	164-172	serpin family A member 1	Homo sapiens	4-23
7299121-0	1981	Response of human neutrophils to C5a: a role for the oligosaccharide moiety of human C5ades Arg-74 but not of C5a in biologic activity.	Arginine	92-95	complement C5a receptor 1	Homo sapiens	85-88
6117511-3	1981	Besides there exists a decreased stimulation of growth hormone (HGH) excretion after arginine infusion at different stages of the treatment.	Arginine	85-93	growth hormone 1	Homo sapiens	48-62
7276568-3	1981	C-reactive protein previously was shown to selectively and reversibly precipitate with certain small polymers of arginine and lysine.	Arginine	113-121	C-reactive protein	Homo sapiens	0-18
7319114-8	1981	These findings indicate that insulin protect against arginine-induced hyperkalaemia and that this metabolic alteration does not depend on glucagon, acidosis, enhance plasma osmolality, nor the suppression of aldosterone secretion.	Arginine	53-61	insulin	Homo sapiens	29-36
7026970-3	1981	We examined the effects of infusions of either prostaglandin E2 (PGE2) or sodium salicylate (SS), a PG synthesis inhibitor, on the acute insulin responses (AIR"s) to arginine and isoproterenol and on the glucose potentiation of the insulin response to arginine in both normal and diabetic subjects.	Arginine	166-174	insulin	Homo sapiens	137-144
7035234-6	1981	In the arginine infusion test, insulin response was not so exaggerated but plasma glucagon was significantly higher (p less than 0.05 vs control value) at each 30, 45, 60 minutes after arginine infusion, and the mean glucagon area under the curves was significantly greater (p less than 0.05 vs control value).	Arginine	7-15	insulin	Homo sapiens	31-38
7035234-6	1981	In the arginine infusion test, insulin response was not so exaggerated but plasma glucagon was significantly higher (p less than 0.05 vs control value) at each 30, 45, 60 minutes after arginine infusion, and the mean glucagon area under the curves was significantly greater (p less than 0.05 vs control value).	Arginine	7-15	glucagon	Homo sapiens	82-90
7035234-6	1981	In the arginine infusion test, insulin response was not so exaggerated but plasma glucagon was significantly higher (p less than 0.05 vs control value) at each 30, 45, 60 minutes after arginine infusion, and the mean glucagon area under the curves was significantly greater (p less than 0.05 vs control value).	Arginine	185-193	glucagon	Homo sapiens	82-90
7026333-0	1981	Failure of indomethacin to affect arginine-induced C-peptide and glucagon release in insulin-treated diabetics.	Arginine	34-42	insulin	Homo sapiens	51-60
7026333-8	1981	Confirming previous reports, we found that the blood glucose rise after arginine was three to four times higher in subjects without C-peptide than in subjects with C-peptide.	Arginine	72-80	insulin	Homo sapiens	132-141
7026333-8	1981	Confirming previous reports, we found that the blood glucose rise after arginine was three to four times higher in subjects without C-peptide than in subjects with C-peptide.	Arginine	72-80	insulin	Homo sapiens	164-173
6167628-2	1981	The EAE-inducing determinant (synthetic peptide S6) H-Ala-Gln-Gly-His-Arg-Pro-Gln-Asp-Glu-Asn-OH (residues 75 to 84) of the bovine MBP induced clinical and histologic signs of EAE when it was administered at doses of 0.5 micrograms or higher.	Arginine	70-73	myelin basic protein	Bos taurus	131-134
6115583-2	1981	In our perfusion experiment, the somatostatin response to 19 mM arginine in the presence of 4.4 mM glucose was significantly greater in both ventromedial hypothalamus (VMH)-lesioned and Zucker fa/fa rats than in their controls, as was the perfusate insulin.	Arginine	64-72	somatostatin	Rattus norvegicus	33-45
7029989-0	1981	Effect of Calcitonin on plasma glucose, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetic subjects.	Arginine	92-100	growth hormone 1	Homo sapiens	64-78
7306088-0	1981	Potent inhibition of thrombin by the newly synthesized arginine derivative No.	Arginine	55-63	coagulation factor II, thrombin	Homo sapiens	21-29
7029989-1	1981	The present study was aimed at investigating the effect of calcitonin on plasma glucose, C-peptide, glucagon and growth hormone (GH) responses to arginine in insulin-dependent diabetic subjects.	Arginine	146-154	growth hormone 1	Homo sapiens	113-127
7029989-1	1981	The present study was aimed at investigating the effect of calcitonin on plasma glucose, C-peptide, glucagon and growth hormone (GH) responses to arginine in insulin-dependent diabetic subjects.	Arginine	146-154	growth hormone 1	Homo sapiens	129-131
7029989-5	1981	Plasma GH rise following arginine administration was significantly inhibited by calcitonin.	Arginine	25-33	growth hormone 1	Homo sapiens	7-9
7019246-9	1981	Their acute glucagon response to arginine was inhibited by the insulin infusion: 701 +/- 112 (basal), 427 +/- 33 (rate 1), and 293 +/- 67 ng/liter per 10 min (rate 2) as was their peak glucagon response: 268 +/- 69, 170 +/- 36, and 115 +/- 33 ng/liter (all P less than 0.01).	Arginine	33-41	insulin	Homo sapiens	63-70
6266543-3	1981	The side chain of arginine, n-propylguanidinium (nPG), reversibly decreases peak sodium conductance and increases the speed of sodium current decay, when perfused internally.	Arginine	18-26	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	49-52
6113132-0	1981	Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas.	Arginine	34-42	somatostatin	Rattus norvegicus	54-66
6113132-2	1981	Insulin (15 mU/ml) significantly and rapidly suppressed glucose- and arginine-stimulated somatostatin release.	Arginine	69-77	somatostatin	Rattus norvegicus	89-101
7311080-0	1981	[The inhibitory effect of sulpiride on arginine-stimulated serum gastrin and growth hormone in normal subjects and peptic ulcer patients (author"s transl)].	Arginine	39-47	growth hormone 1	Homo sapiens	77-91
7242371-0	1981	Dopaminergic modulation of arginine mediated growth hormone and prolactin release in man.	Arginine	27-35	growth hormone 1	Homo sapiens	45-59
6785297-5	1981	Thus, the release of LH, FSH, TSH, and PRL in response to adequate acute stimuli at the pituitary level is not modulated by hyperglycemia in insulin-dependent diabetes, while arginine-induced GH release is suppressed.	Arginine	175-183	prolactin	Homo sapiens	39-42
6117112-0	1981	[Lack of activity of diphenhydramine in the secretion of prolactin and insulin induced by arginine].	Arginine	90-98	insulin	Homo sapiens	71-78
6791697-7	1981	Modification of 5--6 of the 9 apolipoprotein B arginine residues with 1,2-cyclohexanedione/borate or of 10--15 of the 20 lysine residues by reductive methylation does not alter the ability of LDL to bind to erythrocytes.	Arginine	47-55	apolipoprotein B	Homo sapiens	30-46
7242673-0	1981	A human proinsulin variant at arginine 65.	Arginine	30-38	insulin	Homo sapiens	8-18
7032508-0	1981	The role of the arginine-B22 residue in insulin action.	Arginine	16-24	insulin	Homo sapiens	40-47
7032508-1	1981	We describe the modification of the side chain of the arginine-B22 residue of insulin by the N8N9-(1, 2-dihydroxycyclohex-1,2-ylene) group and by the adipoyl group.	Arginine	54-62	insulin	Homo sapiens	78-85
7032508-2	1981	These are the first insulin derivatives described that contain a modified arginine residue in an otherwise unaltered molecule.	Arginine	74-82	insulin	Homo sapiens	20-27
6790279-1	1981	Previous studies have shown that a modified form of antithrombin, cleaved at a single Arg-Ser bond near the carboxy-terminal end of the chain, is formed during the reaction with thrombin concurrent with the formation of the inactive enzyme-inhibitor complex.	Arginine	86-89	coagulation factor II, thrombin	Homo sapiens	56-64
6788884-5	1981	Comparative mapping of the arginine-labeled tryptic peptides from Qa-2, H-2Kb, and H-2Db molecules indicate that Qa-2 is structurally distinct but that there is considerable structural homology; 21-43% of the Qa-2 peptides co-chromatograph with peptides derived from H-2Db and H-2Kb, respectively.	Arginine	27-35	Qa lymphocyte antigen 2 region	Mus musculus	66-70
6165919-4	1981	(2) Intravenous arginine infusion (30 G/30 min) induced identical patterns of plasma growth hormone in 8 patients with multiple sclerosis in relapse, in 6 patients with multiple sclerosis in the stable phase, and in 7 patients in whom no neurological disease was eventually diagnosed.	Arginine	16-24	growth hormone 1	Homo sapiens	85-99
7250128-0	1981	Modification of arginine residues in porcine pancreatic phospholipase A2.	Arginine	16-24	phospholipase A2 group IB	Homo sapiens	56-72
7250128-3	1981	Upon reaction of [7-(14)C]phenylglyoxal monohydrate with alpha-amino-blocked phospholipase A2 analogs, two molecules of the reagent were incorporated per protein molecule, which were found to be present on Arg-6.	Arginine	206-209	phospholipase A2 group IB	Homo sapiens	77-93
7250128-7	1981	Cyclohexanedione modification of Arg-6 in phospholipase A2 does not significantly influence its catalytic activity when assayed toward monomeric and micellar substrates.	Arginine	33-36	phospholipase A2 group IB	Homo sapiens	42-58
6788884-5	1981	Comparative mapping of the arginine-labeled tryptic peptides from Qa-2, H-2Kb, and H-2Db molecules indicate that Qa-2 is structurally distinct but that there is considerable structural homology; 21-43% of the Qa-2 peptides co-chromatograph with peptides derived from H-2Db and H-2Kb, respectively.	Arginine	27-35	Qa lymphocyte antigen 2 region	Mus musculus	113-117
6788884-5	1981	Comparative mapping of the arginine-labeled tryptic peptides from Qa-2, H-2Kb, and H-2Db molecules indicate that Qa-2 is structurally distinct but that there is considerable structural homology; 21-43% of the Qa-2 peptides co-chromatograph with peptides derived from H-2Db and H-2Kb, respectively.	Arginine	27-35	Qa lymphocyte antigen 2 region	Mus musculus	113-117
6113182-3	1981	In perfused rat pancreas from 36 h fasted rats a 5 min pulse of arginine (8 mmol/l) rapidly elicited a peak of somatostatin release.	Arginine	64-72	somatostatin	Rattus norvegicus	111-123
6111928-5	1981	By 3.5 of analogue infusion, plasma glucose had risen by 116 +/- 13 mg/dl, and base-line insulin levels and the insulin responses to both isoproterenol and arginine, but not glucose, increased toward control values.	Arginine	156-164	insulin	Homo sapiens	112-119
6789321-4	1981	Examination of the amphiphilic alpha-helical segments of apo A-I suggested that the preferential interaction of apo A-I with the mixed vesicles might be due to the presence of polar arginine residues in the otherwise hydrophobic regions of two of the helices.	Arginine	182-190	apolipoprotein A1	Homo sapiens	57-64
6789321-4	1981	Examination of the amphiphilic alpha-helical segments of apo A-I suggested that the preferential interaction of apo A-I with the mixed vesicles might be due to the presence of polar arginine residues in the otherwise hydrophobic regions of two of the helices.	Arginine	182-190	apolipoprotein A1	Homo sapiens	112-119
7209542-1	1981	The affinity of the amino terminal tetrapeptide of the beta chain of fibrin, Gly-His-Arg-Pro, for fibrinogen dramatically increases in the presence of 2 millimolar calcium ion.	Arginine	85-88	fibrinogen beta chain	Homo sapiens	98-108
7018149-13	1981	By contrast, insulin and glucagon responses to arginine infusion were significantly reduced by the drug.	Arginine	47-55	insulin	Homo sapiens	13-20
7018150-6	1981	When arginine was preceded by a small oral glucose load (0.5 g/kg) the initial insulin response to arginine was augmented, the initial glucagon response was slightly but significantly depressed and blood glucose lowered while the growth hormone response was unaffected.	Arginine	5-13	insulin	Homo sapiens	79-86
7018150-6	1981	When arginine was preceded by a small oral glucose load (0.5 g/kg) the initial insulin response to arginine was augmented, the initial glucagon response was slightly but significantly depressed and blood glucose lowered while the growth hormone response was unaffected.	Arginine	99-107	insulin	Homo sapiens	79-86
7030721-4	1981	Insulin secretion was significantly increased in IAP treated pancreatic islets by the glucose and the arginine stimuli.	Arginine	102-110	insulin	Homo sapiens	0-7
6113182-4	1981	A similar somatostatin response was evoked by a second, identical, pulse of arginine after perfusion with "basal" glucose (3.9 mmol/l) for 45 min.	Arginine	76-84	somatostatin	Rattus norvegicus	10-22
6113182-5	1981	On the other hand when 27.7 mmol/l D-glucose, was administered for 20 min between arginine pulses, there was significant stimulation of somatostatin secretion.	Arginine	82-90	somatostatin	Rattus norvegicus	136-148
6113182-8	1981	The somatostatin response to arginine was higher in pancreata from fed than from 36 h fasted animals as was also basal release (22.8 +/- 5.0 vs 9.0 +/- 2.0 pg/min).	Arginine	29-37	somatostatin	Rattus norvegicus	4-16
6792262-1	1981	To investigate a possible hypothalamic alteration in obesity, we have studied the pattern of PRL secretion in response to insulin hypoglycemia, arginine infusion and TRH injection in 12 grossly obese patients and in 12 normal-weight controls.	Arginine	144-152	prolactin	Homo sapiens	93-96
6792262-2	1981	In the obese patients, PRL secretion was significantly lower than in normal subjects in response to insulin hypoglycemia and arginine infusion, while it was not significantly different from that in controls in response to TRH.	Arginine	125-133	prolactin	Homo sapiens	23-26
7244331-0	1981	[Effect of phentolamine, diphenhydramine and cyproheptadine on arginine-induced growth hormone secretion (author"s transl)].	Arginine	63-71	growth hormone 1	Homo sapiens	80-94
6109991-0	1981	Effects of prosomatostatin on growth hormone and prolactin response to arginine in man.	Arginine	71-79	prolactin	Homo sapiens	49-58
6109991-2	1981	The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS).	Arginine	81-89	growth hormone 1	Homo sapiens	98-112
6109991-2	1981	The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS).	Arginine	81-89	growth hormone 1	Homo sapiens	114-116
6113955-9	1981	These results seem to support the idea that endogenous somatostatin suppressed glucose-induced insulin and arginine-induced glucagon secretion.	Arginine	107-115	somatostatin	Rattus norvegicus	55-67
7009630-5	1981	In the arginine infusion test, the insulin response was not as exaggerated.	Arginine	7-15	insulin	Homo sapiens	35-42
7009630-6	1981	Plasma glucagon, however, was significantly higher (P less than 0.05 vs. the control value) 30, 45, and 60 min after arginine infusion, and the mean glucagon area under the curves was significantly greater (P less than 0.05 vs. the control value).	Arginine	117-125	glucagon	Homo sapiens	7-15
7205129-1	1981	Arginine is a potent stimulus to the secretion of placental lactogen (PL) as well as GH and prolactin in sheep.	Arginine	0-8	chorionic somatomammotropin hormone	Ovis aries	50-68
6161885-5	1981	Pure preparations of polymorphonuclear neutrophils liberate PAF passively, when challenged with C5a, neutrophil cationic proteins (CP), their carboxypeptidase B derived products (C5a des Arg, CP des Arg) or under phagocytic stimuli.	Arginine	187-190	complement C5a receptor 1	Homo sapiens	179-182
7216471-2	1981	MCP-1 was remarkably rich in arginine (25.5 mol%) and half cystine (18.7 mol%) residues and constituted approximately 1.5% of the total protein content of Freund adjuvant-elicited alveolar macrophages.	Arginine	29-37	corticostatin-3	Oryctolagus cuniculus	0-5
7205129-1	1981	Arginine is a potent stimulus to the secretion of placental lactogen (PL) as well as GH and prolactin in sheep.	Arginine	0-8	chorionic somatomammotropin hormone	Ovis aries	70-72
7205129-7	1981	The results indicate that ornithine is also a potent stimulus to the secretion of PL, GH and prolactin and suggest that arginine-induced PL secretion may result from the conversion of arginine to ornithine.	Arginine	120-128	chorionic somatomammotropin hormone	Ovis aries	82-84
7205129-7	1981	The results indicate that ornithine is also a potent stimulus to the secretion of PL, GH and prolactin and suggest that arginine-induced PL secretion may result from the conversion of arginine to ornithine.	Arginine	120-128	chorionic somatomammotropin hormone	Ovis aries	137-139
7205129-7	1981	The results indicate that ornithine is also a potent stimulus to the secretion of PL, GH and prolactin and suggest that arginine-induced PL secretion may result from the conversion of arginine to ornithine.	Arginine	184-192	chorionic somatomammotropin hormone	Ovis aries	137-139
7451994-0	1981	Enhancement of the chemotactic activity of human C5a des Arg by an anionic polypeptide ("cochemotaxin") in normal serum and plasma.	Arginine	57-60	complement C5a receptor 1	Homo sapiens	49-52
7044004-3	1981	Aminopeptidase preferred Lys-, Phe-, ARg-, and Met-2-naphthylamides as substrates.	Arginine	37-40	carboxypeptidase Q	Homo sapiens	0-14
7451994-1	1981	The potent chemoattractant, C5a is converted rapidly to C5a des Arg by a carboxypeptidase-like enzyme in normal human serum and plasma.	Arginine	64-67	complement C5a receptor 1	Homo sapiens	28-31
7451994-1	1981	The potent chemoattractant, C5a is converted rapidly to C5a des Arg by a carboxypeptidase-like enzyme in normal human serum and plasma.	Arginine	64-67	complement C5a receptor 1	Homo sapiens	56-59
7451994-2	1981	Highly purified human C5a des Arg, at concentrations less than 120 ng/ml, is devoid of chemotactic activity for polymorphonuclear leukocytes.	Arginine	30-33	complement C5a receptor 1	Homo sapiens	22-25
7451994-7	1981	Purified "cochemotaxin" acted in a concentration-dependent fashion to permit low concentrations (20 to 160 ng/ml) of C5a des Arg to attract polymorphonuclear leukocytes.	Arginine	125-128	complement C5a receptor 1	Homo sapiens	117-120
7451994-8	1981	Chemotactic activity varied with the input of C5a des Arg and "cochemotaxin" and was maximal when the 2 polypeptides were combined at equal protein concentrations.	Arginine	54-57	complement C5a receptor 1	Homo sapiens	46-49
7451994-9	1981	The profile of chemotactic activity exhibited by C5a des Arg and its "cochemotaxin" very closely resembled that exhibited by dilutions of activated serum and by highly purified C5a.	Arginine	57-60	complement C5a receptor 1	Homo sapiens	49-52
7451994-9	1981	The profile of chemotactic activity exhibited by C5a des Arg and its "cochemotaxin" very closely resembled that exhibited by dilutions of activated serum and by highly purified C5a.	Arginine	57-60	complement C5a receptor 1	Homo sapiens	177-180
7451994-10	1981	These data suggest that the bulk of chemotactic activity generated in whole serum after complement activation can be accounted for by C5a des Arg and its "cochemotaxin".	Arginine	142-145	complement C5a receptor 1	Homo sapiens	134-137
7013296-3	1981	The cholinergic stimulation increased, and the cholinergic blockade decreased the insulin and glucagon secretion during intravenous L-arginine infusion, both in healthy subjects and in diabetics, these effects being less marked (not significantly) in the latter group of test persons.	Arginine	132-142	insulin	Homo sapiens	82-89
6765589-1	1981	The effect of arginine infusion on blood glucose and plasma levels of insulin, C-peptide and glucagon has been studied in leukemic children before and after treatment with L-asparaginase (10,000 U/m2/day for 10 days).	Arginine	14-22	insulin	Homo sapiens	70-77
6765589-1	1981	The effect of arginine infusion on blood glucose and plasma levels of insulin, C-peptide and glucagon has been studied in leukemic children before and after treatment with L-asparaginase (10,000 U/m2/day for 10 days).	Arginine	14-22	insulin	Homo sapiens	79-88
6784135-7	1981	Acute insulin response to arginine (5 g iv) was also increased by LAS infusion.	Arginine	26-34	insulin	Homo sapiens	6-13
7017570-3	1981	There was a markedly blunted insulin secretory response to glucagon, tolbutamide, glucose, and arginine.	Arginine	95-103	insulin	Homo sapiens	29-36
7237270-4	1980	The CB-1 peptide moved rapidly to the cathode in polyacrylamide gel electrophoresis at pH 3.9 and contained nine arginine residues, three lysine residues, and no acidic amino acid residues.	Arginine	113-121	cannabinoid receptor 1	Homo sapiens	4-8
6162771-3	1980	Glucose (10 mg/kg/min) or arginine (250 mg/kg/min) infusion for 5 min into the superior pancreaticoduodenal artery caused a prompt, parallel increase in IRI and CPR.	Arginine	26-34	cytochrome p450 oxidoreductase	Canis lupus familiaris	161-164
6109241-2	1980	The plasma growth hormone level after arginine simulations was normal in 13 out of 15 children.	Arginine	38-46	growth hormone 1	Homo sapiens	11-25
7012801-0	1980	[Blood serum C-peptide level after arginine stimulation in the early and later stage of insulin-dependent diabetes].	Arginine	35-43	insulin	Homo sapiens	13-22
7213342-10	1980	Treatment of the cleavage products of the complex with carboxypeptidase B yields 1 mumol of arginine, a new C-terminal amino acid, per mumol of thrombin dissociated.	Arginine	92-100	coagulation factor II, thrombin	Homo sapiens	144-152
6256217-0	1980	[Insulin response to glucose and arginine in patients with isolated ACTH deficiency (author"s transl)].	Arginine	33-41	proopiomelanocortin	Homo sapiens	68-72
7001174-0	1980	Portal and peripheral vein concentrations of insulin and glucagon after arginine infusion in morbidly obese subjects.	Arginine	72-80	insulin	Homo sapiens	45-52
7213342-11	1980	The results indicate that during formation of the antithrombin III--thrombin complex, the inhibitor is cleaved at an arginine--X bond; this arginine residue forms a carboxylic ester with the enzyme, while the excised polypeptide remains bound through a disulphide bridge(s).	Arginine	117-125	coagulation factor II, thrombin	Homo sapiens	54-62
7213342-11	1980	The results indicate that during formation of the antithrombin III--thrombin complex, the inhibitor is cleaved at an arginine--X bond; this arginine residue forms a carboxylic ester with the enzyme, while the excised polypeptide remains bound through a disulphide bridge(s).	Arginine	140-148	coagulation factor II, thrombin	Homo sapiens	54-62
7391083-6	1980	The decrease in enzymatic activity correlates with the modification of about 1 arginine residue/phospholipase A2 molecule.	Arginine	79-87	phospholipase A2 group IB	Homo sapiens	96-112
7438472-5	1980	There was a paradoxical decline of GH levels following arginine-insulin infusion and an abnormal GH release with TRH administration.	Arginine	55-63	growth hormone 1	Homo sapiens	35-37
6106616-4	1980	Glucagon secretion stimulated by arginine in the presence of 4.4 mmol/l glucose was potentiated by VIP.	Arginine	33-41	vasoactive intestinal peptide	Rattus norvegicus	99-102
6997162-10	1980	By contrast, glucose (100 and 300 mg/100 ml), tolbutamide (100 microgram/ml), L-arginine (10 mM) and caffeine (5 mM) caused a significant increase of insulin release from adult pancreata.	Arginine	78-88	insulin	Homo sapiens	150-157
6105610-1	1980	Cyclic somatostatin, at a dose of 700 but not 70 ng/kg/min, inhibited arginine-induced insulin and glucagon release as well as glucose stimulated insulin release in rats in vivo.	Arginine	70-78	somatostatin	Rattus norvegicus	7-19
7002690-3	1980	In summary, these results clearly demonstrate that the exaggerated response of A-cell secretion against arginine challenges in insulin-deficient diabetics is secondary to insulin lack, and the perfect normalization of its response is achieved only when both plasma insulin concentration and glycemic control simulate those of healthy subjects.	Arginine	104-112	insulin	Homo sapiens	127-134
6997331-2	1980	Those acromegalic subjects who were not diabetic exhibited excessive insulin responses to glucose and arginine stimulation.	Arginine	102-110	insulin	Homo sapiens	69-76
6105610-5	1980	A fourth analog, D-Trp8-somatostatin, was more potent than somatostatin with regard to arginine stimulated insulin and glucagon release, and equipotent with somatostatin with respect to glucose stimulated insulin release.	Arginine	87-95	somatostatin	Rattus norvegicus	59-71
6105610-5	1980	A fourth analog, D-Trp8-somatostatin, was more potent than somatostatin with regard to arginine stimulated insulin and glucagon release, and equipotent with somatostatin with respect to glucose stimulated insulin release.	Arginine	87-95	somatostatin	Rattus norvegicus	59-71
6105610-6	1980	These studies show, firstly, that the inhibitory effect of somatostatin analogs on arginine induced insulin release may be different from that when glucose is used as a stimulant and, secondly, that Ala2-D-Trp8-D-Cys14-somatostatin inhibits arginine-induced glucagon release while enhancing insulin release on glucose stimulation.	Arginine	83-91	somatostatin	Rattus norvegicus	59-71
6105610-6	1980	These studies show, firstly, that the inhibitory effect of somatostatin analogs on arginine induced insulin release may be different from that when glucose is used as a stimulant and, secondly, that Ala2-D-Trp8-D-Cys14-somatostatin inhibits arginine-induced glucagon release while enhancing insulin release on glucose stimulation.	Arginine	83-91	somatostatin	Rattus norvegicus	219-231
6105610-6	1980	These studies show, firstly, that the inhibitory effect of somatostatin analogs on arginine induced insulin release may be different from that when glucose is used as a stimulant and, secondly, that Ala2-D-Trp8-D-Cys14-somatostatin inhibits arginine-induced glucagon release while enhancing insulin release on glucose stimulation.	Arginine	241-249	somatostatin	Rattus norvegicus	59-71
6994940-2	1980	While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase after MCP ingestion was observed.	Arginine	62-70	growth hormone 1	Homo sapiens	28-30
6777326-6	1980	Protease solubilized NADPH-cytochrome P450 reductase is inactivated by reagents directed to histidine, arginine and lysine residues.	Arginine	103-111	cytochrome p450 oxidoreductase	Homo sapiens	21-52
6772230-3	1980	It was similar to the chicken riboflavin-binding protein in its behavior on ion-exchange celluloses and affinity to interact with the flavin and its coenzymes, but differed significantly in amino acid composition in that it completely lacked proline and contained less of methionine and arginine.	Arginine	287-295	riboflavin binding protein	Gallus gallus	30-56
6989851-0	1980	Unchanged arginine-induced stimulation of insulin, glucagon, growth hormone, and prolactin after pretreatment with indomethacin in normal man.	Arginine	10-18	insulin	Homo sapiens	42-49
6989851-0	1980	Unchanged arginine-induced stimulation of insulin, glucagon, growth hormone, and prolactin after pretreatment with indomethacin in normal man.	Arginine	10-18	growth hormone 1	Homo sapiens	61-75
6989851-1	1980	The arginine-induced release of insulin, glucagon, GH, and PRL was studied in eight normal male volunteers.	Arginine	4-12	insulin	Homo sapiens	32-39
6108678-5	1980	Similarly, the secretion of insulin, glucagon, pancreatic polypeptide, and somatostatin in response to arginine and acetylcholine was unchanged; arginine stimulated the secretion of all four peptides, whereas acetylcholine stimulated the secretion of insulin and pancreatic polypeptide and inhibited glucagon and somatostatin secretion.	Arginine	103-111	insulin	Homo sapiens	28-35
6998800-3	1980	The acute insulin response (mean change from 3-10 min) to the second arginine pulse was significantly inhibited by furosemide (mean increase: 14.8 +/- 3.0 microU/ml versus 11.7 +/- 2.5 microU/ml, p < 0.01).	Arginine	69-77	insulin	Homo sapiens	10-17
6998800-6	1980	In control experiments, in which saline rather than furosemide was administered, the acute insulin and glucagon response to the first arginine pulse did not differ from that observed with the second pulse.	Arginine	134-142	insulin	Homo sapiens	91-98
6776055-2	1980	The influence of an intravenous supplement of arginine to stimulate endogenous human growth hormone (HGH) secretion, e.g. 4 U HGH/day, on nitrogen retention was studied.	Arginine	46-54	growth hormone 1	Homo sapiens	85-99
7362869-5	1980	To study the mechanism of RFN depletion, we investigated the ability of C5a des arg to aggregate various human neutrophil suspensions.	Arginine	80-83	complement C5a receptor 1	Homo sapiens	72-75
7362869-6	1980	Unfractionated neutrophils and RFN demonstrated prompt in vitro aggregation in response to C5a des arg, whereas this activated complement fragment induced little aggregation in a population enriched for non-RFN.	Arginine	99-102	complement C5a receptor 1	Homo sapiens	91-94
6991327-1	1980	To determine how sulfonylureas affect beta cell function, insulin release in response to isoproterenol and arginine was assessed in 32 normal subjects before and during a tolbutamide infusion.	Arginine	107-115	insulin	Homo sapiens	58-65
6991327-3	1980	When plasma glucose levels were maintained by means of a concomitant variable glucose infusion during tolbutamide, the insulin responses to both isoproterenol and arginine were enhanced (isoproterenol: delta AIR = +55 +/- 15 microU/ml, n = 6, p less than 0.001; arginine: delta AIR = +137 +/- 34 microU/ml, n = 8, p less than 0.001).	Arginine	163-171	insulin	Homo sapiens	119-126
6991327-3	1980	When plasma glucose levels were maintained by means of a concomitant variable glucose infusion during tolbutamide, the insulin responses to both isoproterenol and arginine were enhanced (isoproterenol: delta AIR = +55 +/- 15 microU/ml, n = 6, p less than 0.001; arginine: delta AIR = +137 +/- 34 microU/ml, n = 8, p less than 0.001).	Arginine	262-270	insulin	Homo sapiens	119-126
6987123-3	1980	The infusion of 19 mM arginine significantly augmented secretion of somatostatin and glucagon and attenuated insulin secretion in 48-h fasted rats.	Arginine	22-30	somatostatin	Rattus norvegicus	68-80
6993549-3	1980	In addition, there was a highly significant correlation (p less than 0.01) between these falls and the insulin peaks induced by arginine.	Arginine	128-136	insulin	Homo sapiens	103-110
6993549-9	1980	These findings show that arginine is responsible for a fall in plasma phosphorus that may well be partly related to the insulin response, and an increase in plasma potassium of clinical significance, whose mechanism(s), however, are still obscure.	Arginine	25-33	insulin	Homo sapiens	120-127
6989660-0	1980	Effects of acetylsalicylic acid on blood glucose, plasma FFA, glycerol, 3-hydroxybutyrate, alanine, C-peptide, glucagon and growth hormone responses to arginine in insulin-dependent diabetics.	Arginine	152-160	growth hormone 1	Homo sapiens	124-138
6153930-2	1980	It codes for a signal peptide of 16 amino acids, the HA1 chain of the mature hemagglutinin of 329 amino acids, a connecting region between HA1 and HA2 consisting of a single arginine residue and the HA2 portion of 221 amiino acids.	Arginine	174-182	keratin 32	Homo sapiens	147-150
6990147-0	1980	Interaction of a newly isolated intestinal polypeptide (PHI) with glucose and arginine to effect the secretion of insulin and glucagon.	Arginine	78-86	insulin	Homo sapiens	114-121
6987353-0	1980	C-peptide response to arginine stimulation in diabetic children.	Arginine	22-30	insulin	Homo sapiens	0-9
6987353-2	1980	In control subjects a significant rise of C-peptide levels occurred after the infusion with arginine.	Arginine	92-100	insulin	Homo sapiens	42-51
7376785-3	1980	In 17 obese children SM was within the normal range, when Tf levels were higher and arginine-induced GH peaks lower than in the controls, and a negative correlation was found between Tf basal levels and GH peaks (r = -0.608, P less than 0.01).	Arginine	84-92	growth hormone 1	Homo sapiens	101-103
6892927-3	1980	A peptide, labeled with methionine, leucine, and arginine, which is selectively released from after discharging bag cell clusters comigrates with marker ELH, purified from cluster homogenates, on P-6 gel filtration columns and subsequent isoelectric focusing gels.	Arginine	49-57	S100 calcium binding protein A12	Homo sapiens	196-199
6986529-0	1980	Portal and peripheral vein concentrations of insulin after glucose and arginine infusions in morbidly obese subjects.	Arginine	71-79	insulin	Homo sapiens	45-52
6986310-4	1980	Insulin secretion was stimulated during perifusion with 19.3 mM glucose (1.6 X prestimulation level), 1.5 microM glucagon (2.4), 5mM leucine (2.4), 10 mM arginine (2.7), and 10 mM theophylline (10.0).	Arginine	154-162	insulin	Homo sapiens	0-7
6103639-1	1980	Arginine significantly stimulated the release of insulin, glucagon and somatostatin from the isolated perfused rat pancreas.	Arginine	0-8	somatostatin	Rattus norvegicus	71-83
6103639-2	1980	A sulphonylurea, glibenclamide, markedly enhanced the effect of arginine on somatostatin release and inhibited its effect on glucagon release.	Arginine	64-72	somatostatin	Rattus norvegicus	76-88
6769309-0	1980	Improvement of defective insulin responses to glucose, arginine, and beta-adrenergic stimulation in diabetics by sodium salicylate.	Arginine	55-63	insulin	Homo sapiens	25-32
6103853-0	1980	Somatostatin concentration responds to arginine in portal plasma: effects of fasting, streptozotocin diabetes, and insulin administration in diabetic rats.	Arginine	39-47	somatostatin	Rattus norvegicus	0-12
6103853-3	1980	In both normal and diabetic animals fasted for 24 h, the basal level of somatostatin declined but the magnitude of the arginine-induced elevation of somatostatin was not affected, suggesting a physiologic role of the tetradecapeptide in nutrient homeostasis.	Arginine	119-127	somatostatin	Rattus norvegicus	149-161
6103853-4	1980	When compared with intact rats, diabetic animals were shown to have increased levels of somatostatin before and after arginine administration, both of which were attenuated by insulin replacement therapy.	Arginine	118-126	somatostatin	Rattus norvegicus	88-100
6991312-5	1980	Both phases of the normal biphasic insulin response to arginine were decreased during the initial arginine infusion.	Arginine	55-63	insulin	Homo sapiens	35-42
6991312-5	1980	Both phases of the normal biphasic insulin response to arginine were decreased during the initial arginine infusion.	Arginine	98-106	insulin	Homo sapiens	35-42
518871-7	1979	However, in this case the latent thrombin activity is progressively diminished during the heating process in terms of both clotting activity and hydrolysis of the amide substrate H-D-Phe-Pip-Arg-pNA.	Arginine	191-194	prolactin induced protein	Bos taurus	187-190
7429653-3	1980	Evidence that C5adesArg owns all activities studied is further given by the following findings: chromatographic separation of mixtures of C5a and C5adesArg results in the appearance of two peaks of spasmogenic activity; treatment of C5adesArg with carbopeptidase B does neither lead to release of detectable arginine nor abrogate any of the biological effects; treatment of C5a with carboxypeptidase B reduces the activities quantitatively to those of C5adesArg, and liberates the theoretically expected amount of arginine.	Arginine	308-316	complement C5a receptor 1	Homo sapiens	14-17
7429653-3	1980	Evidence that C5adesArg owns all activities studied is further given by the following findings: chromatographic separation of mixtures of C5a and C5adesArg results in the appearance of two peaks of spasmogenic activity; treatment of C5adesArg with carbopeptidase B does neither lead to release of detectable arginine nor abrogate any of the biological effects; treatment of C5a with carboxypeptidase B reduces the activities quantitatively to those of C5adesArg, and liberates the theoretically expected amount of arginine.	Arginine	308-316	complement C5a receptor 1	Homo sapiens	138-141
7429653-3	1980	Evidence that C5adesArg owns all activities studied is further given by the following findings: chromatographic separation of mixtures of C5a and C5adesArg results in the appearance of two peaks of spasmogenic activity; treatment of C5adesArg with carbopeptidase B does neither lead to release of detectable arginine nor abrogate any of the biological effects; treatment of C5a with carboxypeptidase B reduces the activities quantitatively to those of C5adesArg, and liberates the theoretically expected amount of arginine.	Arginine	514-522	complement C5a receptor 1	Homo sapiens	14-17
7429653-3	1980	Evidence that C5adesArg owns all activities studied is further given by the following findings: chromatographic separation of mixtures of C5a and C5adesArg results in the appearance of two peaks of spasmogenic activity; treatment of C5adesArg with carbopeptidase B does neither lead to release of detectable arginine nor abrogate any of the biological effects; treatment of C5a with carboxypeptidase B reduces the activities quantitatively to those of C5adesArg, and liberates the theoretically expected amount of arginine.	Arginine	514-522	complement C5a receptor 1	Homo sapiens	138-141
6773256-8	1980	Arginine showed a mild, but significant potentiating effect on leucine-stimulated insulin release.	Arginine	0-8	insulin	Homo sapiens	82-89
6989887-0	1980	Plasma C-peptide response to arginine in insulin-dependent diabetic subjects.	Arginine	29-37	insulin	Homo sapiens	7-16
6989887-1	1980	Plasma C-peptide concentrations have been determined in the basal state and in response to intravenous arginine in 10 insulin-dependent diabetics.	Arginine	103-111	insulin	Homo sapiens	7-16
6989887-2	1980	Five patients had fasting C-peptide levels above 0.08 pmol/ml and responded to the arginine infusion with a rise in C-peptide levels of more than 0.2 pmol/ml (responsive diabetics).	Arginine	83-91	insulin	Homo sapiens	116-125
6989887-5	1980	The magnitude of blood glucose rise in response to arginine was inversely correlated with increments in plasma C-peptide.	Arginine	51-59	insulin	Homo sapiens	111-120
44874-5	1979	In six normal subjects, the test was repeated with the addition of somatostatin (250 micrograms bolus, followed by 500 micrograms/hr), which abolished the insulin and growth hormone response to arginine.	Arginine	194-202	growth hormone 1	Homo sapiens	167-181
44874-7	1979	These findings show that arginine is responsible for a fall in plasma phosphorus related to the insulin response, and for an increase in plasma potassium of clinical significance, the mechanism(s) of which, however, are still obscure.	Arginine	25-33	insulin	Homo sapiens	96-103
524350-0	1979	Effect of insulin treatment upon response of extrapancreatic glucagon to arginine.	Arginine	73-81	insulin	Homo sapiens	10-17
395063-0	1979	Influence of therapeutic doses of vincristine on the arginine-induced insulin and growth hormone secretions in man.	Arginine	53-61	insulin	Homo sapiens	70-77
395063-0	1979	Influence of therapeutic doses of vincristine on the arginine-induced insulin and growth hormone secretions in man.	Arginine	53-61	growth hormone 1	Homo sapiens	82-96
488008-1	1979	These studies assessed the ability of glucose infusions to potentiate the acute insulin response (AIR) to iv isoproterenol (12 micrograms), arginine (750 mg), or glucose (5 g) that was previously inhibited by an infusion of somatostatin (SRIF).	Arginine	140-148	insulin	Homo sapiens	80-87
534500-3	1979	The novel features of our method are the use of arginine in the elution of fibronectin from immobilized gelatin [Vuento & Vaheri (1978) Biochem.	Arginine	48-56	fibronectin 1	Homo sapiens	75-86
500110-1	1979	Effects of chemical modification of tyrosine and arginine residues on the conformation and immunochemistry of a fragment corresponding to the last third of bovine serum albumin.	Arginine	49-57	albumin	Homo sapiens	163-176
499636-0	1979	Effect of calcitonin on insulin response to arginine in man.	Arginine	44-52	insulin	Homo sapiens	24-31
499636-1	1979	The aim of the present study was to evaluate the effect of calcitonin on insulin response to intravenous arginine in normal humans.	Arginine	105-113	insulin	Homo sapiens	73-80
499636-3	1979	Calcitonin caused a clear inhibition of the insulin response to arginine (p less than 0.01) and also exaggerated the rise in plasma glucose seen with iv arginine (p less than 0.01).	Arginine	64-72	insulin	Homo sapiens	44-51
505364-1	1979	Modification of 12 arginine residues of bovine Factor Xa with 1,2-cyclohexanedione has resulted in a decrease in heparin sensitivity of the reaction between enzyme and antithrombin-III, whereas the antithrombin-III sensitivity of modified Factor Xa was only slightly affected.	Arginine	19-27	serpin family C member 1	Bos taurus	168-184
505364-1	1979	Modification of 12 arginine residues of bovine Factor Xa with 1,2-cyclohexanedione has resulted in a decrease in heparin sensitivity of the reaction between enzyme and antithrombin-III, whereas the antithrombin-III sensitivity of modified Factor Xa was only slightly affected.	Arginine	19-27	serpin family C member 1	Bos taurus	198-214
474034-0	1979	Study on the reproducibility of human prolactin response to sulpiride, benserazide, insulin hypoglycaemia and arginine infusion.	Arginine	110-118	prolactin	Homo sapiens	38-47
231062-1	1979	Effects of somatostatin on fasting and arginine-or tolbutamide-stimulated insulin release were studied in four patients with insulinoma.	Arginine	39-47	insulin	Homo sapiens	74-81
121658-4	1979	In our patients growth hormone response to arginine infusion was in the normal range, whereas PRL response to TRH was slightly but significantly supranormal in terms of maximum value and maximum increment above baseline value.	Arginine	43-51	growth hormone 1	Homo sapiens	16-30
387543-4	1979	In contrast, the insulin response to intravenously infused arginine was impaired in the short-term group, but was at an approximately normal level in the long-term group.	Arginine	59-67	insulin	Homo sapiens	17-24
489255-2	1979	Application of a new arginine derivative, NG-mesitylene-2-sulfonylarginine, to the synthesis of substance P and neurotensin.	Arginine	21-29	neurotensin	Homo sapiens	112-123
489255-3	1979	A new devised arginine derivative, NG-mesitylene-2-sulfonylarginine, Arg(Mts), was employed for the synthesis of hypothalamic substance P and neurotensin.	Arginine	14-22	neurotensin	Homo sapiens	142-153
489255-3	1979	A new devised arginine derivative, NG-mesitylene-2-sulfonylarginine, Arg(Mts), was employed for the synthesis of hypothalamic substance P and neurotensin.	Arginine	69-72	neurotensin	Homo sapiens	142-153
464051-3	1979	Synthetic inhibitor studies indicate that mouse acrosin has a serine and histidine at its active site and hydrolyzes the peptide bonds of lysine and arginine but of not phenylalanine.	Arginine	149-157	acrosin prepropeptide	Mus musculus	48-55
526090-2	1979	Insulin, gastrin and glucagon responses to oral glucose and intravenous arginine in peptic ulcer patients.	Arginine	72-80	insulin	Homo sapiens	0-7
35531-0	1979	A functional arginine residue in NADPH-dependent aldehyde reductase from pig kidney.	Arginine	13-21	aldo-keto reductase family 1 member B	Sus scrofa	49-67
438602-3	1979	Both arginine and glucose, known modulators of insulin and glucagon secretion, were found to stimulate somatostatin release.	Arginine	5-13	somatostatin	Rattus norvegicus	103-115
477677-0	1979	Pattern of growth hormone response to insulin, arginine and haemodialysis in uraemic children.	Arginine	47-55	growth hormone 1	Homo sapiens	11-25
447838-6	1979	Serum insulin in normal subjects increased 15-20 muU/ml with each arginine infusion.	Arginine	66-74	insulin	Homo sapiens	6-13
35531-6	1979	Butanedione-modified aldehyde reductase could still bind to a blue dextran-Sepharose 4B column suggesting that the modified arginine did not bind NADPH.	Arginine	124-132	aldo-keto reductase family 1 member B	Sus scrofa	21-39
436775-2	1979	[D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity (SLI) to cholecystokinin and arginine.	Arginine	151-159	somatostatin	Canis lupus familiaris	16-28
453245-3	1979	Intravenous glucose tolerance, pituitary GH release in response to arginine infusion, hyperglycemia, and hypoglycemia, and insulin secretion in response to arginine infusion and to hyperglycemia were analyzed.	Arginine	67-75	growth hormone 1	Homo sapiens	41-43
436775-2	1979	[D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity (SLI) to cholecystokinin and arginine.	Arginine	151-159	somatostatin	Canis lupus familiaris	87-99
426665-4	1979	On the other hand, the serum insulin response to arginine was significantly less in both PD and ALS patients than in controls.	Arginine	49-57	insulin	Homo sapiens	29-36
426665-5	1979	Arginine stimulated the release of growth hormone to a similar degree in all three patient groups.	Arginine	0-8	growth hormone 1	Homo sapiens	35-49
429103-4	1979	It is proposed that this feature (in which Phe could be situated near Val and near the Arg-Gly bond of the A alpha chain in the three-dimensional structure of fibrinogen) may be especially advantageous for binding to the enzyme.	Arginine	87-90	fibrinogen beta chain	Homo sapiens	159-169
425782-2	1979	A rise in both, Prl and GH with a maximal increment of 15.9 +/- 6.7 (SE) ng/ml, and 12.4 +/- 4.9 ng/ml above basal levels, respectively, (P less than 0.05) was observed after iv arginine.	Arginine	178-186	prolactin	Homo sapiens	16-19
425782-2	1979	A rise in both, Prl and GH with a maximal increment of 15.9 +/- 6.7 (SE) ng/ml, and 12.4 +/- 4.9 ng/ml above basal levels, respectively, (P less than 0.05) was observed after iv arginine.	Arginine	178-186	growth hormone 1	Homo sapiens	24-26
398985-0	1979	Acetylsalicylic acid augments insulin and C-peptide responses to arginine in diabetes mellitus.	Arginine	65-73	insulin	Homo sapiens	30-37
369260-0	1979	Potentiation and inhibition of insulin release in man following priming with glucose and with arginine--effect of somatostatin.	Arginine	94-102	insulin	Homo sapiens	31-38
421970-4	1979	In the postabsorptive state, arginine infusion was accompanied by an eightfold and a fivefold increment, respectively, in the hepatic venous concentration of insulin and glucagon; SGO doubled and blood glucose increased by 30%.	Arginine	29-37	insulin	Homo sapiens	158-165
421970-9	1979	In the 60-h fasted group, arginine infusion was accompanied by a minimal increase in insulin but a fivefold elevation of the glucagon level.	Arginine	26-34	insulin	Homo sapiens	85-92
456548-0	1979	Influence of acetylsalicylic acid on insulin, glucagon and growth hormone responses to glucose and arginine in healthy subjects.	Arginine	99-107	growth hormone 1	Homo sapiens	59-73
763156-1	1979	In man, the infusion of arginine or isoproterenol elevates immunoreactive glucagon and insulin levels.	Arginine	24-32	insulin	Homo sapiens	87-94
763156-4	1979	Arginine administered as a pulse elicited both insulin and glucagon responses whereas pulses of isoproterenol, at half maximal and maximal insulin-stimulating doses, had little effect on glucagon levels.	Arginine	0-8	insulin	Homo sapiens	47-54
369391-0	1979	Early insulin and glucagon response to subsequent pulses of arginine, glucose, and tolbutamide in normal man.	Arginine	60-68	insulin	Homo sapiens	6-13
495279-0	1979	Effect of intravenous glucose,leucine and arginine on concerntration of insulin in maternal and umbilical cord serum.	Arginine	42-50	insulin	Homo sapiens	72-79
120672-6	1979	Oral glucose load and arginine infusion resulted in a significantly enhanced insulin release.	Arginine	22-30	insulin	Homo sapiens	77-84
35240-4	1979	It is shown that the two biologically essential arginine residues (Arg1 and Arg9) are important for the specific folded bradykinin conformation.	Arginine	48-56	kininogen 1	Homo sapiens	120-130
395095-4	1979	Growth hormone response to arginine infusion was clearly reduced in the second test.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
759249-0	1979	Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine.	Arginine	85-93	somatostatin	Canis lupus familiaris	0-12
759249-6	1979	Biphasic release of glucagon, somatostatin, and pancreatic polypeptide was evoked by 10 mM arginine, the responses first being apparent within less than 30 s. Exogenous insulin (50 mU/ml) infused for 10 min had no statistically significant effect on glucagon, somatostatin, or pancreatic polypeptide secretion.	Arginine	91-99	somatostatin	Canis lupus familiaris	30-42
387567-3	1979	In patients with chronic pancreatitis the plasma insulin response to oral glucose and intravenous arginine was reduced.	Arginine	98-106	insulin	Homo sapiens	49-56
499100-0	1979	Increase by somatostatin of the arginine induced rise in blood glucose in untreated insulin requiring diabetics.	Arginine	32-40	insulin	Homo sapiens	84-91
500381-10	1979	Arginine infusion led to a normal insulin and growth hormone release.	Arginine	0-8	insulin	Homo sapiens	34-41
492415-0	1979	Response of insulin, glucagon and growth hormone to arginine infusion in patients with chronic renal failure.	Arginine	52-60	insulin	Homo sapiens	12-19
478977-6	1979	Structural studies by component isolation, globin chain separation, peptide mapping and aminoacid analysis of abnormal peptides showed that the leucine residue 109 of the alpha-chain was replaced by arginine.	Arginine	199-207	Fc gamma receptor and transporter	Homo sapiens	171-182
492415-0	1979	Response of insulin, glucagon and growth hormone to arginine infusion in patients with chronic renal failure.	Arginine	52-60	growth hormone 1	Homo sapiens	34-48
492415-1	1979	To determine whether glucose intolerance in patients with chronic renal failure could improve by hemodialysis, the effects of arginine infusion on the concentration of blood sugar, insulin, glucagon, growth hormone were examined in healthy volunteers, undialyzed and dialyzed patients with chronic renal failure.	Arginine	126-134	insulin	Homo sapiens	181-188
492415-1	1979	To determine whether glucose intolerance in patients with chronic renal failure could improve by hemodialysis, the effects of arginine infusion on the concentration of blood sugar, insulin, glucagon, growth hormone were examined in healthy volunteers, undialyzed and dialyzed patients with chronic renal failure.	Arginine	126-134	growth hormone 1	Homo sapiens	200-214
492415-4	1979	However, plasma concentrations of growth hormone in both patients 180 min after beginning of arginine infusion gave statistically significant differences.	Arginine	93-101	growth hormone 1	Homo sapiens	34-48
747897-0	1978	Growth hormone modulation of arginine-induced glucagon release: studies of isolated growth hormone deficiency and acromegaly.	Arginine	29-37	growth hormone 1	Homo sapiens	0-14
747897-1	1978	Plasma glucagon and insulin responses to L-arginine were compared in normal controls and patients with isolated growth hormone deficiency and acromegaly.	Arginine	41-51	insulin	Homo sapiens	20-27
711738-7	1978	The loss of enzyme activity in sulfur-rhodanese does not involve cysteinyl residues but can be correlated with the modification of guanidino groups, notably that of Arg-186, the side chain of which may play a role in substrate binding.	Arginine	165-168	thiosulfate sulfurtransferase	Bos taurus	38-47
728996-5	1978	Both the delta- and beta-globin genes contain a large noncoding intervening sequence (950 and 900 bp, respectively) located between the codons for amino acids 104 (arginine) and 105 (leucine).	Arginine	164-172	hemoglobin subunit delta	Homo sapiens	9-31
216007-3	1978	The nucleotide sequences coding for corticotropin and beta-lipotropin are separated on the cDNA by a 6-base-pair sequence encoding lysine and arginine, indicating that the carboxyl terminus of corticotropin is connected on the precursor peptide with the amino terminus of beta-lipotropin by these two amino acids.	Arginine	142-150	proopiomelanocortin	Bos taurus	54-69
687639-1	1978	X-Pro dipeptidyl-aminopeptidase (EC 3.4.14.1) purified homogeneously from the human submaxillary gland was proved to hydrolyze N-terminal dipeptide Arg1-Pro2 and subsequent dipeptide Lys3-Pro4 from substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-gly-Leu-Met-NH2).	Arginine	148-151	tachykinin precursor 1	Homo sapiens	198-209
682972-4	1978	Infusion of somatostatin resulted in supression of both arginine-induced insulin and arginine-induced glucagon release, and marked hyperglycemia ensued.	Arginine	56-64	somatostatin	Rattus norvegicus	12-24
682972-4	1978	Infusion of somatostatin resulted in supression of both arginine-induced insulin and arginine-induced glucagon release, and marked hyperglycemia ensued.	Arginine	85-93	somatostatin	Rattus norvegicus	12-24
682972-5	1978	The administration of [D-Cys14]-somatostatin during arginine infusion produced no associated hyperglycemia.	Arginine	52-60	somatostatin	Rattus norvegicus	32-44
682972-7	1978	These results demonstrate that the hyperglycemic effects of somatostatin in arginine-treated animals do not arise in animals treated with glucagon-specific somatostatin analogs.	Arginine	76-84	somatostatin	Rattus norvegicus	60-72
748015-1	1978	Arginine has been demonstrated to be a potent stimulus to GH and PRL secretion.	Arginine	0-8	prolactin	Homo sapiens	65-68
707342-3	1978	The mean arginine-induced insulin peak and the growth hormone peaks after arginine and insulin remained very high after DM.	Arginine	9-17	insulin	Homo sapiens	26-33
707342-3	1978	The mean arginine-induced insulin peak and the growth hormone peaks after arginine and insulin remained very high after DM.	Arginine	9-17	insulin	Homo sapiens	87-94
707342-3	1978	The mean arginine-induced insulin peak and the growth hormone peaks after arginine and insulin remained very high after DM.	Arginine	74-82	growth hormone 1	Homo sapiens	47-61
687639-3	1978	In contrast, the N-terminal Arg-Pro of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) was not cleaved by the enzyme.	Arginine	28-31	kininogen 1	Homo sapiens	39-49
687639-3	1978	In contrast, the N-terminal Arg-Pro of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) was not cleaved by the enzyme.	Arginine	51-54	kininogen 1	Homo sapiens	39-49
744105-4	1978	Arginine"stimulated IRG secretion in the presence of low glucose (2.7 mM) was potentiated by GIP.	Arginine	0-8	gastric inhibitory polypeptide	Rattus norvegicus	93-96
744105-5	1978	In contrast, GIP augmented arginine-stimulated insulin release only in the presence of arginine concentrations of (less than 20 mM, producing no further increase over a maximal arginine stimulus.	Arginine	27-35	gastric inhibitory polypeptide	Rattus norvegicus	13-16
744105-5	1978	In contrast, GIP augmented arginine-stimulated insulin release only in the presence of arginine concentrations of (less than 20 mM, producing no further increase over a maximal arginine stimulus.	Arginine	87-95	gastric inhibitory polypeptide	Rattus norvegicus	13-16
744105-5	1978	In contrast, GIP augmented arginine-stimulated insulin release only in the presence of arginine concentrations of (less than 20 mM, producing no further increase over a maximal arginine stimulus.	Arginine	87-95	gastric inhibitory polypeptide	Rattus norvegicus	13-16
744105-6	1978	The glucagonotropic effect of GIP in the presence of arginine was found to be suppressed by glucose, with the opposite effect observed with insulin release.	Arginine	53-61	gastric inhibitory polypeptide	Rattus norvegicus	30-33
668153-0	1978	Glucagon response to arginine in growth hormone deficient children before and after treatment with growth hormone and in children with non-endocrine short stature.	Arginine	21-29	growth hormone 1	Homo sapiens	33-47
672618-1	1978	The effect of calcitonin administration on basal and arginine-stimulated growth hormone and insulin plasma levels was investigated.	Arginine	53-61	growth hormone 1	Homo sapiens	73-87
672618-1	1978	The effect of calcitonin administration on basal and arginine-stimulated growth hormone and insulin plasma levels was investigated.	Arginine	53-61	insulin	Homo sapiens	92-99
668153-2	1978	60 min after arginine infusion, the growth hormone deficient children had significantly higher (P less than 0.05) plasma glucagon values than the children with non-endocrine short stature.	Arginine	13-21	growth hormone 1	Homo sapiens	36-50
668153-3	1978	Following short-term growth hormone therapy (2 iu qd or bid for 5 days) in eleven of these growth hormone deficient children, plasma pancreatic glucagon response to arginine was diminished, and there was a significantly (P less than 0.02) more rapid return to basal values than in the untreated group.	Arginine	165-173	growth hormone 1	Homo sapiens	21-35
668153-6	1978	The persistent glucagon response to arginine noted in growth hormone deficient children might reflect a greater gluconeogenic stress imposed upon these children during fasting or decreased catabolism of glucagon in the growth hormone deficient state.	Arginine	36-44	growth hormone 1	Homo sapiens	54-68
668153-6	1978	The persistent glucagon response to arginine noted in growth hormone deficient children might reflect a greater gluconeogenic stress imposed upon these children during fasting or decreased catabolism of glucagon in the growth hormone deficient state.	Arginine	36-44	growth hormone 1	Homo sapiens	219-233
279010-5	1978	The ligand (C5a) displays specific structural features that are required for binding because analogs of C5a such as C5ades Arg or a yeast carboxypeptidase-digested C5a derivative C5a-(I-69) inhibited the binding but C3a anaphylatoxin, which resembles C5a chemically, did not.	Arginine	123-126	complement C5a receptor 1	Homo sapiens	12-15
350677-2	1978	The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion.	Arginine	137-145	insulin	Homo sapiens	15-24
350677-2	1978	The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion.	Arginine	223-231	insulin	Homo sapiens	15-24
694820-0	1978	Substrate activation in the thrombin-catalyzed hydrolysis of synthetic esters of arginine.	Arginine	81-89	coagulation factor II, thrombin	Homo sapiens	28-36
669099-0	1978	The effect of acetylsalicylic acid on insulin response to glucose and arginine in normal man.	Arginine	70-78	insulin	Homo sapiens	38-45
669099-5	1978	Arginine stimulated insulin levels were increased after ASA (p is less than 0.01 at 15 min; p is less than 0.05 at 30 min; p is less than 0.05 at 45 min), whereas glucose values were lower than under basal conditions at all times, with significant differences at 105 (p is less than 0.02) and 120 (p is less than 0.05) min.	Arginine	0-8	insulin	Homo sapiens	20-27
669099-6	1978	A possible role of prostaglandins upon the insulin responses to glucose and arginine is discussed.	Arginine	76-84	insulin	Homo sapiens	43-50
680309-0	1978	Plasma insulin response to arginine stimulation in children and adolescents with constitutional short stature according to sex, age, sexual development and skinfold thickness.	Arginine	27-35	insulin	Homo sapiens	7-14
680309-1	1978	The plasma insulin response to a standard arginine stimulation test was studied in 247 children and adolescents (177 males and 70 females) with constitutional growth retardation as compared with the response obtained in a matched group of 42 normal subjects and a group of 57 obese subjects.	Arginine	42-50	insulin	Homo sapiens	11-18
641622-0	1978	Differential effects of cranial radiation on growth hormone response to arginine and insulin infusion.	Arginine	72-80	growth hormone 1	Homo sapiens	45-59
641622-1	1978	The growth hormone responses to arginine infusion and to insulin-induced hypoglycemia were studied in 13 patients with neoplastic disease after treatment with radiation and chemotherapy.	Arginine	32-40	growth hormone 1	Homo sapiens	4-18
678219-7	1978	(4) Of the essential amino acids valine, isoleucine, leucine and arginine were taken up in excess of their requirement for milk protein synthesis.	Arginine	65-73	Weaning weight-maternal milk	Bos taurus	123-127
691822-2	1978	Changes of plasma glucagon and insulin levels in response to arginine infusion (author"s transl)].	Arginine	61-69	insulin	Homo sapiens	31-38
634772-5	1978	Secretion of growth hormone after an infusion of arginine and insulin hypoglycaemia seem to be significantly reduced in comparison with normal subjects and those suffering from common diabetes, paired and explored using the same protocol.	Arginine	49-57	growth hormone 1	Homo sapiens	13-27
97104-0	1978	Growth hormone response to arginine infusion in malnourished children.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
75835-3	1978	3:219, 1974) a hypothesis was proposed that the high dose inhibition of encephalitogenicity in giunea pigs seen with the tryptophan peptide, phe ser trp gly ala glu gly gln arg, and not observed with the whole myelin basic protein which contains this sequence, was the result of competitive inhibition by non-encephalitogenic fragments of the tryptophan peptide produced in vivo possibly by exopeptidases.	Arginine	173-176	myelin basic protein	Sus scrofa	210-230
629857-1	1978	Chemical substitution of the exposed residues of tryptophan, tyrosine, histidine and arginine in carcinoembryonic antigen (CEA), using appropriately selective reagents, caused no significant change in the capacity of the antigen to bind to anti-CEA serum.	Arginine	85-93	CEA cell adhesion molecule 3	Homo sapiens	97-121
629857-1	1978	Chemical substitution of the exposed residues of tryptophan, tyrosine, histidine and arginine in carcinoembryonic antigen (CEA), using appropriately selective reagents, caused no significant change in the capacity of the antigen to bind to anti-CEA serum.	Arginine	85-93	CEA cell adhesion molecule 3	Homo sapiens	123-126
110024-2	1978	The results are compared with the response of serum prolactin to arginine, insulin and TRH.	Arginine	65-73	prolactin	Homo sapiens	52-61
31111-2	1978	Thrombin severs four ARG-GLY bonds in the alpha A and beta B chains of its molecule, on the side of the terminal-N.	Arginine	21-24	coagulation factor II, thrombin	Homo sapiens	0-8
752016-7	1978	Finally, after intravenous arginine, a delayed increase of hPP values was observed, occurring subsequently to the plasma glucose drop.	Arginine	27-35	familial progressive hyperpigmentation 1	Homo sapiens	59-62
603274-4	1977	Serum gastrin levels in response to this dose of arginine were determined before and three weeks, three months and one year after resection of the jejunum and of the ileum.	Arginine	49-57	gastrin	Canis lupus familiaris	6-13
377185-0	1978	C-peptide response to arginine infusion in insulin requiring diabetics.	Arginine	22-30	insulin	Homo sapiens	0-9
377185-0	1978	C-peptide response to arginine infusion in insulin requiring diabetics.	Arginine	22-30	insulin	Homo sapiens	43-50
605445-4	1977	In the old low insulin responders, insulin secretion stimulated by arginine was significantly lower than that in the control group, but the growth hormone secretion was not different from that in control.	Arginine	67-75	insulin	Homo sapiens	15-22
895526-2	1977	Intravenous arginine challenge resulted in similar glucose and glucagon responses and threefold greater integrated insulin responses in the obese when compared to the normal subjects.	Arginine	12-20	insulin	Homo sapiens	115-122
605445-0	1977	Insulin and growth hormone secretion stimulated by intravenous administration of arginine in the low insulin responders (prediabetes?).	Arginine	81-89	insulin	Homo sapiens	0-7
605445-0	1977	Insulin and growth hormone secretion stimulated by intravenous administration of arginine in the low insulin responders (prediabetes?).	Arginine	81-89	growth hormone 1	Homo sapiens	12-26
605445-0	1977	Insulin and growth hormone secretion stimulated by intravenous administration of arginine in the low insulin responders (prediabetes?).	Arginine	81-89	insulin	Homo sapiens	101-108
605445-3	1977	Insulin secretion stimulated by arginine in 6 young low responders was not different from that in the control group matched with regard to age and body weight, and the values of growth hormone during arginine infusion were higher than those of the control group.	Arginine	32-40	insulin	Homo sapiens	0-7
605445-3	1977	Insulin secretion stimulated by arginine in 6 young low responders was not different from that in the control group matched with regard to age and body weight, and the values of growth hormone during arginine infusion were higher than those of the control group.	Arginine	200-208	growth hormone 1	Homo sapiens	178-192
605445-5	1977	The present study showed that insulin and growth hormone secretion stimulated by arginine in young low-insulin-responders were different from those in the old ones.	Arginine	81-89	insulin	Homo sapiens	30-37
605445-5	1977	The present study showed that insulin and growth hormone secretion stimulated by arginine in young low-insulin-responders were different from those in the old ones.	Arginine	81-89	growth hormone 1	Homo sapiens	42-56
605445-5	1977	The present study showed that insulin and growth hormone secretion stimulated by arginine in young low-insulin-responders were different from those in the old ones.	Arginine	81-89	insulin	Homo sapiens	103-110
921942-1	1977	In human deoxyhemoglobin a salt bridge links the alpha carboxyl of Arg-141 of each alpha chain to the epsilon-amino group of Lys-127 of the opposite alpha chain.	Arginine	67-70	Fc gamma receptor and transporter	Homo sapiens	83-94
921942-1	1977	In human deoxyhemoglobin a salt bridge links the alpha carboxyl of Arg-141 of each alpha chain to the epsilon-amino group of Lys-127 of the opposite alpha chain.	Arginine	67-70	Fc gamma receptor and transporter	Homo sapiens	149-160
72949-5	1977	epidemiologically linked with West Africa are more susceptible to tetracycline, require arginine for growth, and their gene coding for beta-lactamase synthesis is contained in a smaller 3-2 X 10(6) dalton plasmid.	Arginine	88-96	beta-lactamase	Neisseria gonorrhoeae	135-149
330566-4	1977	Acute insulin responses to arginine (2 g i.v.)	Arginine	27-35	insulin	Homo sapiens	6-13
409475-0	1977	Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects.	Arginine	124-132	insulin	Homo sapiens	69-76
617571-1	1977	A 28-year-old man with chronic hydrocephalus due to aqueductal stenosis was found to have a subnormal response of growth hormone to arginine infusion.	Arginine	132-140	growth hormone 1	Homo sapiens	114-128
863126-1	1977	The effect of arginine infusion on blood sugar and plasma levels of growth hormone and glucagon has been studied in children with clinical diabetes mellitus and in obese children with normal carbohydrate tolerance.	Arginine	14-22	growth hormone 1	Homo sapiens	68-82
866345-0	1977	Growth hormone response to arginine in normal subjects and in patients with chemical diabetes and effect of clofibrate and of metergoline.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
870793-1	1977	A 20-yr-old female with congenital lipoatrophic diabetes was studied, with the following findings: (1) Serum insulin levels increased after both oral glucose and intravenous arginine administration; there was no growth hormone response to the latter.	Arginine	174-182	insulin	Homo sapiens	109-116
320224-2	1977	Insulin responses to tolbutamide, glucagon, arginine and leucine were determined and insulin resistance was measured with exogenous iv insulin.	Arginine	44-52	insulin	Homo sapiens	0-7
265133-2	1977	Insulin and growth hormone secretion, studied with arginine and insulin stimulation tests, showed a high peak of serum insulin and no response of growth hormone.	Arginine	51-59	insulin	Homo sapiens	0-7
265133-2	1977	Insulin and growth hormone secretion, studied with arginine and insulin stimulation tests, showed a high peak of serum insulin and no response of growth hormone.	Arginine	51-59	growth hormone 1	Homo sapiens	12-26
870515-6	1977	BG rises seen after iv arginine were increased by the administration of GH-RIH both in healthy subjects (P less than 0.001) and in maturity onset diabetics (P less than 0.05).	Arginine	23-31	growth hormone 1	Homo sapiens	72-74
870515-8	1977	IRG increases after arginine administration were diminished by GH-RIH in both groups (P less than 0.01).	Arginine	20-28	growth hormone 1	Homo sapiens	63-65
870515-9	1977	Our data demonstrate that GH-RIH impairs the iv carbohydrate tolerance in healthy subjects and facilities an increased hepatic glucose output upon administration of arginine both in controls and in maturity onset diabetics.	Arginine	165-173	growth hormone 1	Homo sapiens	26-28
559563-0	1977	[Reaction of immunoreactive insulin (IRI) under arginine loading and post-glucose arginine infusion in OGTT-normal insulin low responders].	Arginine	48-56	insulin	Homo sapiens	28-35
842341-1	1977	The glucagon and insulin responses to intravenous arginine were studied in 17 children with cystic fibrosis and in 9 control children.	Arginine	50-58	insulin	Homo sapiens	17-24
920023-0	1977	Comparative effects of glucagon and arginine upon growth hormone secretion in children and adolescents.	Arginine	36-44	growth hormone 1	Homo sapiens	50-64
841147-0	1977	[Inhibition by nonesterified fatty acids of growth hormone secretion induced by intravenous arginine infusion].	Arginine	92-100	growth hormone 1	Homo sapiens	44-58
404727-1	1977	Changes in growth hormone (gh) release in response to L-dopa, TRH, arginine and LH-RH were studied in 15 patients with acromegaly to investigate the mechanism of so-called "paradoxical decrease" of GH secretion often observed in acromegalics after the administration of L-dopa.	Arginine	67-75	growth hormone 1	Homo sapiens	11-25
404727-1	1977	Changes in growth hormone (gh) release in response to L-dopa, TRH, arginine and LH-RH were studied in 15 patients with acromegaly to investigate the mechanism of so-called "paradoxical decrease" of GH secretion often observed in acromegalics after the administration of L-dopa.	Arginine	67-75	growth hormone 1	Homo sapiens	27-29
321441-8	1977	Extensive modification of the arginine residues by PGO occurred with RCM-derivatives of ribonuclease A and insulin B chain.	Arginine	30-38	insulin	Homo sapiens	107-114
194605-1	1977	The polypeptides ACTH and ATCH4-10 (OI 63) witha sequence of amino acids H-Met-Glu-His-Phe-Arg-Trp-Gly-OH, have similar stimulating effects  on motor units in lower mammals.	Arginine	91-94	proopiomelanocortin	Homo sapiens	17-21
612271-3	1977	Intracellular potassium depletion was associated with a slight impaired carbohydrate tolerance and with decreased growth hormone response to arginine infusion and insulin-induced hypoglycemia.	Arginine	141-149	growth hormone 1	Homo sapiens	114-128
844789-2	1977	Exaggerated response of plasma glucagon to arginine infusion in diabetic subjects was normalized in those successfully treated with sulfonylureas and significantly improved in those treated with insulin.	Arginine	43-51	insulin	Homo sapiens	195-202
320081-0	1977	An apparent inhibition of insulin biosynthesis resulting from inhibition of transport of neutral amino acids by arginine.	Arginine	112-120	insulin	Homo sapiens	26-33
320081-1	1977	At concentrations higher than 10 mM, the cationic amino acid, arginine, inhibited the incorporation of neutral amino acids such as alanine, threonine, valine and leucine into insulin in the presence of glucose.	Arginine	62-70	insulin	Homo sapiens	175-182
320081-4	1977	Arginine inhibited the incorporation of leucine not only into insulin but also into other islet proteins.	Arginine	0-8	insulin	Homo sapiens	62-69
136379-9	1977	However, arginine infusion provoked an elevated insulin response in those with a diabetic GTT, and an exaggerated growth hormone response in the majority of the patients.	Arginine	9-17	insulin	Homo sapiens	48-55
893128-5	1977	Analogous to a modification of HbA, i.e. Hb Koelliker (alpha2 minus 141 Arg beta2), the structure of the degradation product of HbF is alpha2 minus 141 Arg gamma2 (HbF Koelliker).	Arginine	152-155	tryptophanyl-tRNA synthetase 1	Homo sapiens	156-162
908554-2	1977	Arginine-insulin stimulation and IV glucose suppression (AIGT) tests were used to evaluate release of insulin and growth hormone.	Arginine	0-8	insulin	Homo sapiens	9-16
834141-2	1977	In addition, the secretory capacities of the alpha and beta cells were assessed by measurement of the amounts of glucagon and insulin released after intravenous administration of glucose and arginine, respectively.	Arginine	191-199	insulin	Homo sapiens	126-133
852930-1	1977	The C-terminal undecapeptide of ovine prolactin, H-Leu-Asn-Cys-Arg-Ile-Ile-Try-Asn-Asn-Asn-Cys-OH possesses several structural features common to protein proteinase inhibitors, yet has no inhibitor properties.	Arginine	63-66	prolactin	Homo sapiens	38-47
852930-1	1977	The C-terminal undecapeptide of ovine prolactin, H-Leu-Asn-Cys-Arg-Ile-Ile-Try-Asn-Asn-Asn-Cys-OH possesses several structural features common to protein proteinase inhibitors, yet has no inhibitor properties.	Arginine	63-66	endogenous retrovirus group K member 25	Homo sapiens	154-164
874581-3	1977	The amount of carbon dioxide gas adsorbed by lysozyme, its hydrolyzates and gelatin hydrolyzates depended upon the lysine content, arginine content and average molecular weight.	Arginine	131-139	lysozyme	Homo sapiens	45-53
562351-0	1977	Synthesis of analogues of bradykinin with replacement of the arginine residues by 4-guanidinophenyl-l-alanine.	Arginine	61-69	kininogen 1	Homo sapiens	26-36
834141-6	1977	Similarly, insulin responses after arginine infusion between young and old were indistinguishable.	Arginine	35-43	insulin	Homo sapiens	11-18
976604-7	1976	Infusion of insulin under these conditions progressively decreased glucagon responses to arginine to values (9.6 +/- 0.8; p less than 0.01) that, at four hours, were similar to those of normal subjects and to values found at the end of the 14-hour infusion of insulin in the same diabetic individuals.	Arginine	89-97	insulin	Homo sapiens	12-19
1002996-12	1976	Human C5a contains a COOH-terminal arginine which is essential for anaphylatoxin activity and a sequence of Gln-Leu-Gly-Arg-COOH at the COOH-terminus which compares favorably with that of human C3a (Gly-Leu-Ala-Arg-COOH).	Arginine	35-43	complement C5a receptor 1	Homo sapiens	6-9
1002996-12	1976	Human C5a contains a COOH-terminal arginine which is essential for anaphylatoxin activity and a sequence of Gln-Leu-Gly-Arg-COOH at the COOH-terminus which compares favorably with that of human C3a (Gly-Leu-Ala-Arg-COOH).	Arginine	120-123	complement C5a receptor 1	Homo sapiens	6-9
996852-4	1976	In group I, the mean plasma insulin levels during glucose tolerance test were the same as those in the controls, but the insulin response to arginine was reduced except in two cases.	Arginine	141-149	insulin	Homo sapiens	121-128
996852-6	1976	The ratio of increment area of insulin to that of glucagon during arginine infusion in the patients was slightly decreased in comparison with the controls.	Arginine	66-74	insulin	Homo sapiens	31-38
188635-7	1976	Insulin, glucagon and growth hormone secretions caused by arginine were also found normal, but during the period the patient was on propranolol therapy, all responses were decreased, within the normal range.	Arginine	58-66	insulin	Homo sapiens	0-7
188635-9	1976	They do not either agree with the contention that secretions of insulin, glucagon and growth hormone induced by arginine are mediated through beta-receptors.	Arginine	112-120	insulin	Homo sapiens	64-71
190057-3	1976	The pancreatic islets of tumor-bearing animals secreted less glucagon and insulin in response to arginine or to changes in the glucose concentration of the medium, than did the islets of control hamsters.	Arginine	97-105	insulin	Homo sapiens	74-81
993322-0	1976	Effect of the dopamine receptor blocking agent pimozide on the growth hormone response to arginine and exercise and on the spontaneous growth hormone fluctuations.	Arginine	90-98	growth hormone 1	Homo sapiens	63-77
976605-7	1976	Pretreatment with either glucose or xylitol almost completely restored the biphasic insulin response to arginine in patients with hyperthyroidism, whereas pretreatment with aminophylline only partially improved the insulin response.	Arginine	104-112	insulin	Homo sapiens	84-91
976605-9	1976	with arginine also restored the normal second-phase insulin release, with blood glucose rises similar to those in normal subjects given arginine alone.	Arginine	5-13	insulin	Homo sapiens	52-59
976605-10	1976	It is concluded that the plasma insulin response to arginine is impaired, especially in its second phase, in patients with hyperthyroidism due to the absence of a blood glucose rise.	Arginine	52-60	insulin	Homo sapiens	32-39
976605-11	1976	The second phase of arginine-induced insulin release seems more dependent on glucose than the first phase.	Arginine	20-28	insulin	Homo sapiens	37-44
976604-8	1976	These results demonstrate a rapid effect of insulin on glucagon responses to arginine and suggest that the abnormal responses seen in diabetes mellitus are the immediate result of insulin deficiency.	Arginine	77-85	insulin	Homo sapiens	44-51
976605-0	1976	Imparied plasma insulin response to arginine in hyperthyroidism.	Arginine	36-44	insulin	Homo sapiens	16-23
976605-6	1976	of arginine provoked similar uniphasic plasma insulin responses in both normal subjects and hyperthyroid patients.	Arginine	3-11	insulin	Homo sapiens	46-53
956343-0	1976	Effect of the antihistaminic agents meclastine and dexchlorpheniramine on the response of human growth hormone to arginine infusion and insulin hypoglycemia.	Arginine	114-122	growth hormone 1	Homo sapiens	96-110
783201-0	1976	Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects.	Arginine	0-8	insulin	Homo sapiens	35-42
783201-6	1976	Although the acute insulin response to arginine was normal, there was marked attentuation of the early beta-cell response upon stimulation by glucose.	Arginine	39-47	insulin	Homo sapiens	19-26
958001-5	1976	Intravenous administration of arginine resulted in a subnormal insulin response of 28 muU/ml in the base-line test and an increase to 59 muU/ml after potassium stores were repleted.	Arginine	30-38	insulin	Homo sapiens	63-70
958001-6	1976	Growth hormone response to arginine infusion was also initially minimal at 12.5 ng/ml, increasing markedly to 26 ng/ml after potassium replenishment.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
937363-3	1976	Growth hormone secretion was provoked by arginine infusion but not by hypoglycemia.	Arginine	41-49	growth hormone 1	Homo sapiens	0-14
991831-0	1976	Direct inhibitions of basal and arginine-induced plasma gastrin secretion by somatostatin in anesthetized dogs.	Arginine	32-40	gastrin	Canis lupus familiaris	56-63
991831-3	1976	Somatostatin suppressed basal gastrin level promptly in the right gastroepiploic vein and impaired the normal gastrin secretion in response to intravenous infusion of arginine.	Arginine	167-175	gastrin	Canis lupus familiaris	110-117
795689-4	1976	Parenteral administration of synthetic SRIF inhibits the release of growth hormone, basal and stimulated by muscular exercise, arginine, L-DOPA, insulin-induced hypoglycemia, and sleeping.	Arginine	127-135	growth hormone 1	Homo sapiens	68-82
820711-0	1976	Suppression by thyrotropin-releasing hormone (TRH) of growth hormone release induced by arginine and insulin-induced hypoglycemia in man.	Arginine	88-96	growth hormone 1	Homo sapiens	54-68
820711-1	1976	Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)-induced hypoglycemia in normal men.	Arginine	73-83	growth hormone 1	Homo sapiens	7-21
2474-3	1976	Since in the single crystal structure tyrosine-10 is involved in an intermolecular interaction with arginine-42 of the neighboring protein molecule, the NMR data thus reveal a local conformation difference for bovine pancreatic trypsin inhibitor in solution and in the crystalline form which appears to result primarily from intermolecular interaction in the crystal lattice.	Arginine	100-108	trophoblast Kunitz domain protein 1	Bos taurus	228-245
773953-15	1976	Growth hormone values in serum after the infusion of arginine followed a similar pattern, i.e., decreased after high carbohydrate but unaffected by other diets in men; high carbohydrate diets did not alter the growth hormone response of women to arginine.	Arginine	53-61	growth hormone 1	Homo sapiens	0-14
1255312-1	1976	Subnormal growth hormone responses to both insulin-induced hypoglycemia and arginine infusion (peak response less than or equal to 5 ng/ml) were found in five male subjects (aged 10 to 14 years) with short stature but with normal interval growth rates and normal bone ages (in 4 cases).	Arginine	76-84	growth hormone 1	Homo sapiens	10-24
959042-0	1976	Serum insulin, pancreatic glucagon and growth hormone levels in response to intravenous infusion of L-arginine in patients with recently detected juvenile diabetes.	Arginine	100-110	insulin	Homo sapiens	6-13
959042-0	1976	Serum insulin, pancreatic glucagon and growth hormone levels in response to intravenous infusion of L-arginine in patients with recently detected juvenile diabetes.	Arginine	100-110	growth hormone 1	Homo sapiens	39-53
1258634-5	1976	In 34 of 40 patients, the response to the short test was comparable to the response during the arginine-insulin test; only 3 patients with a normal 11-DOCS rise to the short test had a low response to insulin and vice versa.	Arginine	95-103	insulin	Homo sapiens	104-111
1261961-0	1976	Effect of metergoline, a specific serotonin antagonist, on human growth hormone response to arginine and L-dopa.	Arginine	92-100	growth hormone 1	Homo sapiens	65-79
1107504-3	1976	Plasma GH values were suppressed following oral administration of glucose and increased following insulin-induced hypoglycemia, L-dopa, and arginine.	Arginine	140-148	insulin	Homo sapiens	98-105
3198-2	1976	N-acetyl-L-phenylalaninamide, support our previous conclusion (Biochemistry 12, 3780, 1973) that the positive 221-nm CD band of bradykinin is a composite of bands due to two chromophores, the 217-nm band characteristic of the Phe residues overlying the 223-nm band of the N-terminal sequence, Arg-Pro-Pro.	Arginine	293-296	kininogen 1	Homo sapiens	128-138
1012175-0	1976	[Personal research on the determination of somatotropin following arginine, insulin and testosterone administration].	Arginine	66-74	growth hormone 1	Homo sapiens	43-55
946565-2	1976	Effect of somatostatin on arginine induced release of insulin and glucagon in man and perfused rat pancreas.	Arginine	26-34	insulin	Homo sapiens	54-61
946565-3	1976	In man, 3 mug per kg per 90 min of linear somatostatin significantly inhibited basal as well as arginine induced insulin and glucagon release.	Arginine	96-104	insulin	Homo sapiens	113-120
1262446-2	1976	Intravenous infusion of arginine caused biphasic increases in plasma glucagon and insulin in all subjects studied.	Arginine	24-32	insulin	Homo sapiens	82-89
1262446-4	1976	Plasma insulin response to arginine was exaggerated by xylitol infusion.	Arginine	27-35	insulin	Homo sapiens	7-14
1262446-5	1976	Repeated arginine pulses given at 30 min intervals evoked uniphasic and almost identical rises of plasma insulin and glucagon with each pulse.	Arginine	9-17	insulin	Homo sapiens	105-112
1262446-6	1976	Intravenous xylitol infusions significantly blunted plasma glucagon responses and augumented the plasma insulin response to arginine pulses, despite only slight elevations of plasma glucose.	Arginine	124-132	insulin	Homo sapiens	104-111
1254112-0	1976	Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes mellitus.	Arginine	58-66	insulin	Homo sapiens	10-17
1254112-1	1976	The effect of insulin on the glucagon response to intravenous arginine was studied in eight juvenile-type and six adult-onset diabetics.	Arginine	62-70	insulin	Homo sapiens	14-21
1254112-8	1976	This study demonstrates that in juvenile-type diabetics concomitant administration of supraphysiologic quantities of insulin can reduce the exaggerated glucagon response to intravenous arginine to normal, whereas in the adult-type group, it has no apparent effect.	Arginine	185-193	insulin	Homo sapiens	117-124
2300-3	1976	Degradation of arginine vasopressin is slower than oxytocin in all species studied, and appears to occur by a different overall mechanism since cleavage of the Pro-Arg bond is more significant than hydrolysis of the Arg-Gly bond.	Arginine	164-167	arginine vasopressin	Homo sapiens	24-35
2300-3	1976	Degradation of arginine vasopressin is slower than oxytocin in all species studied, and appears to occur by a different overall mechanism since cleavage of the Pro-Arg bond is more significant than hydrolysis of the Arg-Gly bond.	Arginine	216-219	arginine vasopressin	Homo sapiens	24-35
179927-1	1976	The insulin response to oral glucose, tolbutamide, arginine, pancreozymin and cerulein was studied in a group of subjects with insuloma and a group of normal control subjects.	Arginine	51-59	insulin	Homo sapiens	4-11
212233-6	1976	The following conclusion was drawn: alpha-MSH possesses (in contrast to ACTH) two message sequences (active sites), (i)-Glu-His-Phe-Arg-Trp-, and (ii)-Gly-Lys-Pro-Val-NH2 which are capable of independently triggering the hormone receptor responsible for melanin dispersion.	Arginine	132-135	proopiomelanocortin	Homo sapiens	36-45
1206104-1	1975	Infusion of insulin (1 U/hr) for 14 hr suppressed basal glucagon levels and normalized previously excessive glucagon responses to arginine in juvenile-onset, insulin-dependent diabetic subjects, indicating that abnormal pancreatic alpha-cell function in human juvenile-onset diabetes mellitus may be a consequence of insulin lack.	Arginine	130-138	insulin	Homo sapiens	12-19
1249182-0	1976	Prolactin response to arginine in normal subjects and in patients with hyperthyroidism.	Arginine	22-30	prolactin	Homo sapiens	0-9
1249182-1	1976	The effect of arginine on serum prolactin concentrations was studied in 18 normal subjects and in 7 patients with hyperthyroidism in normal subjects, arginine infusion produced an increase of serum prolactin at least 6 ng/ml from the baseline, and the mean peak level (25.2 +/- 3.3 ng/ml, mean +/- SE) was significantly higher than the basal level (8.6 +/- 5.2 ng/ml, P less than 0.001).	Arginine	14-22	prolactin	Homo sapiens	32-41
1249182-1	1976	The effect of arginine on serum prolactin concentrations was studied in 18 normal subjects and in 7 patients with hyperthyroidism in normal subjects, arginine infusion produced an increase of serum prolactin at least 6 ng/ml from the baseline, and the mean peak level (25.2 +/- 3.3 ng/ml, mean +/- SE) was significantly higher than the basal level (8.6 +/- 5.2 ng/ml, P less than 0.001).	Arginine	150-158	prolactin	Homo sapiens	198-207
1249182-4	1976	In hyperthyroid patients, the increment of serum prolactin after arginine infusion at 30 min (3.9 +/- 1.5 ng/ml) was significantly lower than that of the normal controls which were matched by age and sex (17.1 +/- 4.4 ng/ml, P less than 0.05).	Arginine	65-73	prolactin	Homo sapiens	49-58
1249182-5	1976	After treatment when these patients were euthyroid, the increment of prolactin after arginine infusion at 30 min was significantly increased (16.3 +/- 4.3 ng/ml, P less than 0.05) and had reached the level of control subjects.	Arginine	85-93	prolactin	Homo sapiens	69-78
1249182-6	1976	These data indicate that the prolactin response to arginine in hyperthyroidism is diminished.	Arginine	51-59	prolactin	Homo sapiens	29-38
1206104-0	1975	Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin.	Arginine	91-99	insulin	Homo sapiens	152-159
1278844-9	1976	The growth-hormone response to an arginine stimulus was lower after alcohol than after saline in all subjects.	Arginine	34-42	growth hormone 1	Homo sapiens	4-18
1185416-5	1975	Growth hormone responses to arginine, insulin, sleep, L-dopa, and glucagon were uniformly less than 2.5 ng/ml.	Arginine	28-36	growth hormone 1	Homo sapiens	0-14
1191673-6	1975	Modification of arginine residues in thrombin did not result in decreased thrombin activity and decreased sensitivity to antithrombin, whereas the heparin sensitivity of the enzyme and the thrombin-antithrombin reaction were diminished.	Arginine	16-24	coagulation factor II, thrombin	Homo sapiens	37-45
1691-1	1975	The major protein in beta nerve growth factor preparations, beta1NGF, is a dimer in which both peptide chains have COOH-terminal arginine residues.	Arginine	129-137	nerve growth factor	Homo sapiens	21-45
1201152-0	1975	Growth hormone response to insulin and to arginine in patients with familial hypercholesterolaemia.	Arginine	42-50	growth hormone 1	Homo sapiens	0-14
1159580-0	1975	Evaluation of growth hormone release in children using arginine and L-dopa in combination.	Arginine	55-63	growth hormone 1	Homo sapiens	14-28
1183925-0	1975	Effect of aminophylline on growth hormone and insulin responses to arginine in normal subjects.	Arginine	67-75	insulin	Homo sapiens	46-53
1105371-0	1975	Plasma growth hormone, insulin, and glucagon responses to arginine infusion in children and adolescents with idiopathic short stature, isolated growth hormone deficiency, panhypopituitarism, and anorexia nervosa.	Arginine	58-66	growth hormone 1	Homo sapiens	7-21
807787-5	1975	Insulin response, both to glucose and to arginine infusion, was clearly reduced.	Arginine	41-49	insulin	Homo sapiens	0-7
1183914-0	1975	The influence of plasma triglycerides on human growth hormone response to arginine and insulin: a study in hyperlipemics and normal subjects.	Arginine	74-82	growth hormone 1	Homo sapiens	47-61
1183914-1	1975	Human growth hormone (HGH) response to arginine (25 gm IV in 30 min) and to insulin (0.1 U/kg B.W.)	Arginine	39-47	growth hormone 1	Homo sapiens	6-20
1105371-3	1975	After arginine infusion, four- to sixfold increases of plasma GH were observed in the normal children, and similar increases were seen in those with idiopathic short stature as well as in those with anorexia nervosa; whereas, in the children with isolated growth hormone deficiency or panhypopituitarism, there was no significant increase in plasma GH.	Arginine	6-14	growth hormone 1	Homo sapiens	62-64
1105371-3	1975	After arginine infusion, four- to sixfold increases of plasma GH were observed in the normal children, and similar increases were seen in those with idiopathic short stature as well as in those with anorexia nervosa; whereas, in the children with isolated growth hormone deficiency or panhypopituitarism, there was no significant increase in plasma GH.	Arginine	6-14	growth hormone 1	Homo sapiens	349-351
1202424-1	1975	Studies were conducted in four normal and six diabetic children to assess the role of adrenergic blockade on basal and arginine-stimulated growth hormone and glucagon secreation.	Arginine	119-127	growth hormone 1	Homo sapiens	139-153
1158037-0	1975	Arginine-stimulated acute phase of insulin and glucagon secretion.	Arginine	0-8	insulin	Homo sapiens	35-42
1158037-5	1975	Peak glucagon and insulin levels averaging four and five times basal levels respectively were reached two to five minutes after arginine administration and had returned to baseline levels by fifteen to thirty minutes.	Arginine	128-136	insulin	Homo sapiens	18-25
1158037-12	1975	The effect of induced hyperglycemia on the acute phase of insulin and glucagon secretion was assessed by administering the arginine during marked elevation of ambient glucose concentration achieved by the intravenous administration of glucose.	Arginine	123-131	insulin	Homo sapiens	58-65
1143089-1	1975	Arginine-induced insulin and glucagon secretion preceding and following clofibrate treatment was studied in 13 patients with endogenous hypertriglyceridemia.	Arginine	0-8	insulin	Homo sapiens	17-24
1143089-7	1975	After clofibrate treatment there is also a significant reduction in fasting GLI levels and in the insulin response to arginine, and an increase in the glucagon response.	Arginine	118-126	insulin	Homo sapiens	98-105
170711-4	1975	Increased levels in the maximal plasma insulin were observed in 63%, 100% and 56% through the glucose test, the tolbutamide test and the arginine test, respectively.	Arginine	137-145	insulin	Homo sapiens	39-46
1155081-4	1975	In the arginine and insulin tolerance tests the initially high immunoreactive growth hormone levels were later followed by a decrease to high normal values.	Arginine	7-15	growth hormone 1	Homo sapiens	78-92
1138156-2	1975	In normal subjects 150 mug of somatostatin completly suppressed GH and IRI responses to arginine, while with 75 and 37.5 mug only a partial suppression was usually observed.	Arginine	88-96	growth hormone 1	Homo sapiens	64-66
125287-0	1975	Exaggerated growth hormone response to arginine infusion in Huntington"s disease.	Arginine	39-47	growth hormone 1	Homo sapiens	12-26
125287-1	1975	Growth hormone regulation was studied in 10 patients with Huntington"s disease after intravenous administration of arginine.	Arginine	115-123	growth hormone 1	Homo sapiens	0-14
125287-2	1975	In 20 control subjects arginine infusion resulted in a rise of plasma growth hormone levels from a mean baseline value of 3.2+/-0.6 ng/ml to a peak level of 17.6+/-2.7 ng/ml at 60 min.	Arginine	23-31	growth hormone 1	Homo sapiens	70-84
125287-4	1975	Carbohydrate tolerance of these patients was previously examined, and 4 with normal glucose tolerance and normal insulin responses to arginine infusion had growth hormone levels significantly higher than controls at 30 min.	Arginine	134-142	insulin	Homo sapiens	113-120
125287-4	1975	Carbohydrate tolerance of these patients was previously examined, and 4 with normal glucose tolerance and normal insulin responses to arginine infusion had growth hormone levels significantly higher than controls at 30 min.	Arginine	134-142	growth hormone 1	Homo sapiens	156-170
125287-5	1975	Six patients with impaired carbohydrate tolerance and exaggerated insulin responses to arginine had significantly higher growth hormone responses at 30 min and also at 60 min.	Arginine	87-95	insulin	Homo sapiens	66-73
125287-5	1975	Six patients with impaired carbohydrate tolerance and exaggerated insulin responses to arginine had significantly higher growth hormone responses at 30 min and also at 60 min.	Arginine	87-95	growth hormone 1	Homo sapiens	121-135
125287-7	1975	The observations that growth hormone responds in an exaggerated fashion to stimulation by arginine infusion or falling glucose levels as previously described may be explained by intrahypothalamic dysfunction such as impairment of somatostatin secretion.	Arginine	90-98	growth hormone 1	Homo sapiens	22-36
1223943-1	1975	Twenty hyperthyroid patients were investigated for growth hormone (GH) and immunoreactive insulin (IRI) secretion in response to insulin hypoglycaemia, arginine infusion and glucose-induced hyperglycaemia.	Arginine	152-160	insulin	Homo sapiens	90-97
1236817-14	1975	Effect of arginine on the concentrations of serum hGH, hPRL and hCS during pregnancy.	Arginine	10-18	prolactin	Homo sapiens	55-59
1236817-18	1975	Effect of arginine on the concentrations of serum hGH and hPRL in puerperium.	Arginine	10-18	prolactin	Homo sapiens	58-62
1138243-0	1975	[Blood levels of insulin, pancreatic glucagon and growth hormone following intravenous infusion of L-arginine in patients with recently diagnosed juvenile diabetes].	Arginine	99-109	insulin	Homo sapiens	17-24
811925-1	1975	The effects of tolbutamide, glibenclamide, arginine and arginine in combination with glibenclamide upon insulin, glucagon and glucose serum levels have been studied in healthy young men.	Arginine	56-64	insulin	Homo sapiens	104-111
1223943-2	1975	GH response to either insulin hypoglycaemia or arginine infusion was significantly reduced in these patients compared with 20 normal subjects.	Arginine	47-55	growth hormone 1	Homo sapiens	0-2
1149950-5	1975	Under similar conditions, metergoline administration caused a slight but significant decrease in arginine-induced insulin release, both in normal subjects and in chemical diabetics.	Arginine	97-105	insulin	Homo sapiens	114-121
165218-2	1975	A marked growth hormone (GH) response was seen only in 2 out of 8 constitutionally small children with a normal GH response to insulin and arginine stimulation.	Arginine	139-147	growth hormone 1	Homo sapiens	9-23
165218-2	1975	A marked growth hormone (GH) response was seen only in 2 out of 8 constitutionally small children with a normal GH response to insulin and arginine stimulation.	Arginine	139-147	growth hormone 1	Homo sapiens	25-27
1153917-0	1975	The effect of somatostatin on the rise of growth hormone and glucagon secretion induced by arginine and L-dopa in diabetic patients.	Arginine	91-99	growth hormone 1	Homo sapiens	42-56
1153917-2	1975	The plasma growth hormone response to arginine and L-dopa was completely inhibited by somatostatin.	Arginine	38-46	growth hormone 1	Homo sapiens	11-25
166707-0	1975	[Hydrolysis of the methyl esters of the N-arylsulfonyl derivatives of L-arginine by thrombin and trypsin].	Arginine	70-80	coagulation factor II, thrombin	Homo sapiens	84-92
1092707-6	1975	These data establish that the administration of somatostatin can effectively block the release of insulin stimulated by arginine and glucose, can attenuate the release of glucagon induced by arginine and can enhance the glucose-mediated glucagon suppression.	Arginine	120-128	insulin	Homo sapiens	98-105
1116488-3	1975	Both oxytocin and vasopressin are degraded by an enzyme which cleaves their Pro-X bonds, to release Leu-Gly-NH2 from oxytocin and Arg-Gly-NH2 from vasopressin.	Arginine	130-133	arginine vasopressin	Rattus norvegicus	18-29
1116488-3	1975	Both oxytocin and vasopressin are degraded by an enzyme which cleaves their Pro-X bonds, to release Leu-Gly-NH2 from oxytocin and Arg-Gly-NH2 from vasopressin.	Arginine	130-133	arginine vasopressin	Rattus norvegicus	147-158
1116650-6	1975	Arginine, in the presence of glucose and theophylline, caused excessive glucagon release but nearly normal insulin release in the diabetics.	Arginine	0-8	insulin	Cricetulus griseus	107-114
235578-3	1975	Buffalo beta-casein possesses identical end-groups to those of cow beta-casein; namely N-terminal arginine and assuming a single polypeptide chain a possible C-terminal sequence of Ile-Ile-Val.	Arginine	98-106	casein beta	Bos taurus	8-19
1112778-6	1975	Bovine panctreatic RNase A loses approximately 90% of its activity on cyclohexanedione treatment with the modification of 2 to 3 arginine residues.	Arginine	129-137	ribonuclease pancreatic	Bos taurus	19-26
48419-8	1975	The following amino acids were found in CEA: lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, emthionine, isoleucine, leucine, tyrosine, phenylalanine, and cysteine.	Arginine	64-72	CEA cell adhesion molecule 3	Homo sapiens	40-43
817219-5	1975	Somatostatin, MIF, oxytocin, arg-vasopressin, arg-vasotocin, neurophysin II and glucagon do not compete; and pGlu-His-Pro-OH, Glu-His-Pro-OH, pGlu-His, His-Pro-NH2, and Pro-NH2 do not affect enzyme activity.	Arginine	29-32	arginine vasopressin	Rattus norvegicus	33-44
1207275-0	1975	[Effect of arginine on insulin liberation during intra-abdominal operations].	Arginine	11-19	insulin	Homo sapiens	23-30
1207275-2	1975	An arginine-infusion of 0,5 g/kg over 30 minutes is able to stimulate the basal as well as the glucose stimulated insulin secretion under stress condition.	Arginine	3-11	insulin	Homo sapiens	114-121
1207275-3	1975	A synergism between the effect of arginine and blood glucose concentration concerning the influence on insulin secretion can be proven.	Arginine	34-42	insulin	Homo sapiens	103-110
1227012-0	1975	[Inhibition of endotoxin-, hyperthermia- as well as arginine-induced growth hormone secretion due to somatostatin in healthy subjects and insulin-dependent diabetics].	Arginine	52-60	growth hormone 1	Homo sapiens	69-83
1234063-1	1975	The insulin and glucagon responses to arginine infusion were investigated in patients with maturity-onset diabetes under control conditions and during metformin therapy.	Arginine	38-46	insulin	Homo sapiens	4-11
4620121-0	1974	Effect of ageing on insulin and growth hormone response to glucose and arginine in normal subjects.	Arginine	71-79	growth hormone 1	Homo sapiens	32-46
4431650-0	1974	[Effect of intravenous arginine loading on the release of growth hormone and level of plasma immunoreactive insulin in obese children].	Arginine	23-31	growth hormone 1	Homo sapiens	58-72
4431650-0	1974	[Effect of intravenous arginine loading on the release of growth hormone and level of plasma immunoreactive insulin in obese children].	Arginine	23-31	insulin	Homo sapiens	108-115
4421828-0	1974	Insulin response to arginine in normal newborn infants and infants of diabetic mothers.	Arginine	20-28	insulin	Homo sapiens	0-7
4478623-0	1974	[Proceedings: Arginine and synthesis and secretory functions of growth hormone and prolactin].	Arginine	14-22	growth hormone 1	Homo sapiens	64-78
4375978-4	1974	It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp- in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly- which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far.	Arginine	105-108	proopiomelanocortin	Homo sapiens	32-40
4826615-0	1974	Endocrine function of the pancreas in cystic fibrosis: evidence for an impaired glucagon and insulin response following arginine infusion.	Arginine	120-128	insulin	Homo sapiens	93-100
4478623-0	1974	[Proceedings: Arginine and synthesis and secretory functions of growth hormone and prolactin].	Arginine	14-22	prolactin	Homo sapiens	83-92
4375978-4	1974	It appears to be related to the beta-MSH species of mammalian species but has only the sequence -His-Phe-Arg-Trp- in common with the heptapeptide core -Met-Glu-His-Phe-Arg-Trp-Gly- which is characteristic not only of the MSH peptides but also of the adrenocorticotrophins and lipotrophins studied so far.	Arginine	168-171	proopiomelanocortin	Homo sapiens	32-40
4831710-0	1974	Plasma insulin and glucagon responses to arginine in patients with thyroid dysfunction.	Arginine	41-49	insulin	Homo sapiens	7-14
4816888-0	1974	Quantitative study on the potentiating effect of arginine on glucose-induced insulin response in healthy, prediabetic, and diabetic subjects.	Arginine	49-57	insulin	Homo sapiens	77-84
4476360-0	1974	[Proceedings: Effects of aging on arginine induction of insulin secretion].	Arginine	34-42	insulin	Homo sapiens	56-63
4452431-0	1974	Growth hormone responses to arginine infusion in patients with chronic pancreatitis: relationship to glucose intolerance and insulinopenia.	Arginine	28-36	growth hormone 1	Homo sapiens	0-14
4450221-0	1974	Suppressive effect of glucocorticoid on arginine-induced growth hormone release in normal subjects.	Arginine	40-48	growth hormone 1	Homo sapiens	57-71
4350845-0	1973	Effect of clofibrate on arginine-induced insulin and glucagon secretion.	Arginine	24-32	insulin	Homo sapiens	41-48
4201417-0	1973	Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF.	Arginine	78-86	prolactin	Homo sapiens	0-9
4201417-0	1973	Prolactin and growth hormone release in response to sequential stimulation by arginine and synthetic TRF.	Arginine	78-86	growth hormone 1	Homo sapiens	14-28
4728208-0	1973	Human growth hormone secretion after double stimulation with arginine in normal and insulin-dependent diabetic women.	Arginine	61-69	growth hormone 1	Homo sapiens	6-20
4710580-0	1973	pH dependence of the equilibrium constant for the hydrolysis of the Arg 63 -Ile reactive-site peptide bond in soybean trypsin inhibitor (Kunitz).	Arginine	68-71	kunitz trypsin protease inhibitor	Glycine max	118-135
4735568-9	1973	Blunted GH response to both arginine and insulin-induced hypoglycaemia may also result from continuous secretion and reduced pituitary storage of growth hormone.	Arginine	28-36	growth hormone 1	Homo sapiens	146-160
4698247-0	1973	Effects of single and multiple pulses of arginine on insulin release in man.	Arginine	41-49	insulin	Homo sapiens	53-60
4723200-0	1973	[Serum growth hormone and insulin level in newborn infants, in basal conditions, after oral glucose load and after intravenous arginine perfusion].	Arginine	127-135	growth hormone 1	Homo sapiens	7-21
4542150-0	1973	Modification of basal and arginine-induced growth hormone secretion by concomitant fat administration.	Arginine	26-34	growth hormone 1	Homo sapiens	43-57
4750802-0	1973	Serum insulin and growth hormone response to arginine infusion in healthy and psoriatic persons.	Arginine	45-53	growth hormone 1	Homo sapiens	18-32
4653986-0	1972	The advantages of combined stimulation by arginine and insulin in the study of the secretion of growth hormone.	Arginine	42-50	growth hormone 1	Homo sapiens	96-110
4665093-1	1972	Human growth hormone (HGH) responses in 20 healthy adults to subcutaneous glucagon, arginine infusion and tolbutamide and insulin hypoglycemia were compared.	Arginine	84-92	growth hormone 1	Homo sapiens	6-20
5068400-0	1972	Stimulation of immunoreactive insulin and human growth hormone release by administration of arginine in patients with diabetic retinopathy.	Arginine	92-100	insulin	Homo sapiens	30-37
5068400-0	1972	Stimulation of immunoreactive insulin and human growth hormone release by administration of arginine in patients with diabetic retinopathy.	Arginine	92-100	growth hormone 1	Homo sapiens	48-62
5066206-0	1972	[Comparison between insulin and arginine in secretion stimulation tests of growth hormone].	Arginine	32-40	growth hormone 1	Homo sapiens	75-89
4346919-2	1973	Interaction of tolbutamide with glucagon, aminophylline and arginine in stimulating insulin response.	Arginine	60-68	insulin	Homo sapiens	84-91
4696695-0	1973	Simultaneous identification of PTH derivatives of histidine and arginine by thin-layer chromatography.	Arginine	64-72	parathyroid hormone	Homo sapiens	31-34
4553012-0	1972	Insulin release from human foetal pancreas in response to glucose, leucine and arginine.	Arginine	79-87	insulin	Homo sapiens	0-7
4647913-0	1972	The plasma insulin response to arginine infusion in six non-diabetic patients given an acute overload of thyroid hormone.	Arginine	31-39	insulin	Homo sapiens	11-18
5037840-0	1972	[Plasma levels of growth hormone, insulin and glucose, during sequential intravenous administration of L-arginine and insulin].	Arginine	103-113	growth hormone 1	Homo sapiens	18-32
5071662-0	1972	Blood glucose, serum insulin and growth hormone response to intravenous administration of arginine in premature infants.	Arginine	90-98	growth hormone 1	Homo sapiens	33-47
5135634-0	1971	The serum insulin and growth hormone response to arginine and to arginine with glucose in the premature infant.	Arginine	49-57	growth hormone 1	Homo sapiens	22-36
5156957-0	1971	The adrenergic modulation of the serum insulin response to intravenous arginine in man.	Arginine	71-79	insulin	Homo sapiens	39-46
5135634-0	1971	The serum insulin and growth hormone response to arginine and to arginine with glucose in the premature infant.	Arginine	65-73	growth hormone 1	Homo sapiens	22-36
4673887-2	1972	This third protein (PE2) has now been identified as a precursor of the other viral envelope protein (E2) on the basis of two observations: (i) the simultaneous disappearance of radioactive PE2 and appearance of labeled E2 in pulse-chase experiments, and (ii) the identity of (14)C-arginine tryptic peptides in fingerprints of the two proteins.	Arginine	281-289	ETS2 repressor factor	Homo sapiens	20-23
5172022-0	1971	Reproducibility of plasma growth hormone and insulin responses after double infusion of arginine solution.	Arginine	88-96	growth hormone 1	Homo sapiens	26-40
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Arginine	143-151	somatotropin	Oryctolagus cuniculus	5-19
5563962-0	1971	Human maternal and fetal insulin response to arginine.	Arginine	45-53	insulin	Homo sapiens	25-32
5566388-0	1971	Effects of feeding, fasting, glucose or arginine on plasma prolactin levels in the bovine.	Arginine	40-48	prolactin	Bos taurus	59-68
4928263-5	1971	Alpha adrenergic blockade by the intravenous infusion of phenotolamine significantly suppressed plasma HGH responses to insulin-induced hypoglycemia and to arginine infusion, and enhanced plasma insulin response to arginine infusion.	Arginine	215-223	insulin	Homo sapiens	195-202
4923414-0	1971	The effect of weight loss on the growth hormone response to arginine infusion in obesity.	Arginine	60-68	growth hormone 1	Homo sapiens	33-47
5103997-0	1971	Presence of arginine residues at the strong, hydrophobic anion binding sites of bovine serum albumin.	Arginine	12-20	albumin	Homo sapiens	87-100
5502099-0	1970	Arginine-induced growth hormone responses in children: effect of age and puberty.	Arginine	0-8	growth hormone 1	Homo sapiens	17-31
4098468-0	1970	Arginine-infusion test for growth-hormone secretion.	Arginine	0-8	growth hormone 1	Homo sapiens	27-41
4187998-0	1969	Growth hormone responses to saline and L-arginine.	Arginine	39-49	growth hormone 1	Homo sapiens	0-14
5429963-0	1970	Effect of arginine infusion on plasma levels of growth hormone, insulin, and glucose during pregnancy and the puerperium.	Arginine	10-18	growth hormone 1	Homo sapiens	48-62
5429963-0	1970	Effect of arginine infusion on plasma levels of growth hormone, insulin, and glucose during pregnancy and the puerperium.	Arginine	10-18	insulin	Homo sapiens	64-71
5090059-4	1971	The plasma HGH (human growth hormone) inhibition was associated with elevation in plasma triglycerides and inhibition of plasma FFA (free fatty acid) depression after insulin or arginine.	Arginine	178-186	growth hormone 1	Homo sapiens	22-36
5439008-0	1970	[Estimate of the growth hormone secretion by means of arginine intravenous perfusion in 8 cases of primary hypothyroidism.	Arginine	54-62	growth hormone 1	Homo sapiens	17-31
4895859-0	1969	Arginine induced growth hormone release after clomiphene treatment.	Arginine	0-8	growth hormone 1	Homo sapiens	17-31
5388896-0	1969	Diminished growth hormone response to arginine in the puerperium.	Arginine	38-46	growth hormone 1	Homo sapiens	11-25
5788263-0	1969	Fluctuations of human growth hormone secretion during menstrual cycle: response to arginine.	Arginine	83-91	growth hormone 1	Homo sapiens	22-36
5792915-1	1969	alpha-Adrenergic blockade with phentolamine significantly enhances the insulin response to arginine.	Arginine	91-99	insulin	Homo sapiens	71-78
5792915-2	1969	In women phentolamine may inhibit the growth hormone response to arginine.	Arginine	65-73	growth hormone 1	Homo sapiens	38-52
5817638-0	1969	Serum insulin and growth hormone responses to arginine infusion before and during treatment with contraceptive steroids.	Arginine	46-54	insulin	Homo sapiens	6-13
5817638-0	1969	Serum insulin and growth hormone responses to arginine infusion before and during treatment with contraceptive steroids.	Arginine	46-54	growth hormone 1	Homo sapiens	18-32
12332173-0	1969	Serum insulin and growth hormone responses to arginine infusion before and during treatment with contraceptive steroids.	Arginine	46-54	insulin	Homo sapiens	6-13
12332173-0	1969	Serum insulin and growth hormone responses to arginine infusion before and during treatment with contraceptive steroids.	Arginine	46-54	growth hormone 1	Homo sapiens	18-32
5804184-0	1969	Comparison of arginine infusion and diethylstilbestrol as a means of provoking growth hormone secretion.	Arginine	14-22	growth hormone 1	Homo sapiens	79-93
5786514-0	1969	Arginine-initiated release of human growth hormone.	Arginine	0-8	growth hormone 1	Homo sapiens	36-50
5763118-0	1969	Response of plasma insulin and human growth hormone to arginine in pregnant and postpartum females.	Arginine	55-63	insulin	Homo sapiens	19-26
5774112-3	1969	In response to prolonged intravenous infusion of arginine with pancreozymin there was a maintained rise in immunoreactive insulin and glucagon-like immunoreactivity in the blood.	Arginine	49-57	insulin	Homo sapiens	122-129
5774112-4	1969	These effects of pancreozymin and arginine were not reproduced with secretin and arginine, and may have been due to the stimulation of glucagon secretion together with insulin by pancreozymin.	Arginine	34-42	insulin	Homo sapiens	168-175
5774112-6	1969	Enteric infusion of arginine, presumed to cause release of endogenous pancreozymin, led to a rise in serum immunoreactive insulin not attributable to effects of circulating glucose and amino acids.	Arginine	20-28	insulin	Homo sapiens	122-129
5818625-0	1969	Growth hormone response to arginine in normal and hyperthyroid females under propanolol.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
5762883-0	1969	The effect of arginine infusion on plasma growth hormone and insulin in children.	Arginine	14-22	growth hormone 1	Homo sapiens	42-56
5762883-0	1969	The effect of arginine infusion on plasma growth hormone and insulin in children.	Arginine	14-22	insulin	Homo sapiens	61-68
5776519-4	1969	The expression of resistance to p-fluorophenylalanine by fpr-1 can be suppressed by genes controlling a requirement for lysine or arginine.	Arginine	130-138	formyl peptide receptor 1	Homo sapiens	57-62
5763118-0	1969	Response of plasma insulin and human growth hormone to arginine in pregnant and postpartum females.	Arginine	55-63	growth hormone 1	Homo sapiens	37-51
5376983-0	1969	[Glycoregulation and thyrotoxicosis: insulin secretion during arginine perfusion; role of catecholamines].	Arginine	62-70	insulin	Homo sapiens	37-44
5762319-0	1969	Responses of plasma growth hormone and corticosteroids to insulin and arginine with or without prior administration of dexamethasone.	Arginine	70-78	growth hormone 1	Homo sapiens	20-34
4175511-0	1968	Failure of suppression of arginine-induced growth-hormone response by dexamethasone.	Arginine	26-34	growth hormone 1	Homo sapiens	43-57
4885979-0	1968	Circulating levels of anterior pituitary hormones and insulin after arginine infusion.	Arginine	68-76	insulin	Homo sapiens	54-61
4168383-0	1967	A comparison of the effects of insulin hypoglycaemia and arginine infusion on release of human growth hormone.	Arginine	57-65	growth hormone 1	Homo sapiens	95-109
4173258-0	1968	Non-specificity of arginine infusion as a test for growth-hormone secretion.	Arginine	19-27	growth hormone 1	Homo sapiens	51-65
13573743-0	1957	[The oxidative metabolism of L-arginine in insects; catalase and L-amino acid oxidase activities].	Arginine	29-39	catalase	Homo sapiens	52-60
31253034-2	1968	Blood glucose elevation in response to arginine infusion gives a rough estimate of pancreatic capacity to release insulin.	Arginine	39-47	insulin	Homo sapiens	114-121
6027286-0	1967	Effect of arginine on serum levels of insulin and growth hormone in obese subjects.	Arginine	10-18	insulin	Homo sapiens	38-45
6027286-0	1967	Effect of arginine on serum levels of insulin and growth hormone in obese subjects.	Arginine	10-18	growth hormone 1	Homo sapiens	50-64
5891215-0	1965	Comparative activity of thrombin on substituted arginine and lysine esters.	Arginine	48-56	coagulation factor II, thrombin	Homo sapiens	24-32
6041638-0	1967	The influence of chlorpropamide pre-treatment on insulin and growth hormone release after arginine.	Arginine	90-98	growth hormone 1	Homo sapiens	61-75
4158217-0	1965	Effect of arginine on serum-levels of human growth-hormone.	Arginine	10-18	growth hormone 1	Homo sapiens	44-58
33726573-7	2021	RESULTS: The expression of MeCP2 in H9c2 cells was decreased after H/R treatment.	Arginine	0-1	methyl CpG binding protein 2	Rattus norvegicus	27-32
33872861-0	2021	A Dual Zinc plus Arginine formulation protects against tumor necrosis factor-alpha-induced barrier dysfunction and enhances cell proliferation and migration in an in vitro gingival keratinocyte model.	Arginine	17-25	tumor necrosis factor	Homo sapiens	55-82
33872861-1	2021	OBJECTIVE: To investigate the effects of Dual Zinc plus Arginine formulations (aqueous solution and dentifrice) on tumor necrosis factor-alpha (TNF-alpha)-induced barrier dysfunction as well as on cell proliferation and migration in an in vitro gingival keratinocyte model.	Arginine	56-64	tumor necrosis factor	Homo sapiens	115-142
33872861-1	2021	OBJECTIVE: To investigate the effects of Dual Zinc plus Arginine formulations (aqueous solution and dentifrice) on tumor necrosis factor-alpha (TNF-alpha)-induced barrier dysfunction as well as on cell proliferation and migration in an in vitro gingival keratinocyte model.	Arginine	56-64	tumor necrosis factor	Homo sapiens	144-153
33872861-6	2021	RESULTS: Under conditions where TNF-alpha induces loss of keratinocyte barrier integrity, the Dual Zinc plus Arginine formulations (aqueous solution and dentifrice) protected the keratinocyte tight junction against the damages since they prevented the TNF-alpha-induced drop in TER and increase in FITC-dextran paracellular flux in the in vitro model.	Arginine	109-117	tumor necrosis factor	Homo sapiens	252-261
33872861-10	2021	CONCLUSIONS: The ability of the Dual Zinc plus Arginine formulations to protect the barrier integrity of gingival keratinocytes from TNF-alpha-induced damage and to promote their proliferation and migration suggests that they may offer benefits for oral health.	Arginine	47-55	tumor necrosis factor	Homo sapiens	133-142
33873056-6	2021	The distances from ADP to the His20 in the His-Ser-His motif and the Arg finger (Arg353 or Arg378) in both RUVBL1/2 complex structures bound with or without ADP have significant differences, suggesting dramatically different interactions of the binding site with ADP.	Arginine	69-72	RuvB like AAA ATPase 1	Homo sapiens	107-115
33933489-3	2021	The Pt-Au/R-TNTs with 0.33 wt% of SA metals, exhibited a maximum of 149 times higher photocatalytic performance than unmodified R-TNT and a total apparent quantum yield (AQY) of 17.9%, in which the yield of CH4 and C2H6 reached to 360.0 and 28.8 mumol g-1 h-1, respectively.	Arginine	10-11	chromosome 16 open reading frame 82	Homo sapiens	12-15
34050775-0	2021	A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.	Arginine	117-125	insulin	Homo sapiens	54-61
33848730-4	2021	The resultant CCFS-PVP-L-Arg (CPA) system shows excellent synergetic photothermal and gas therapy (PTT/GT).	Arginine	25-28	carboxypeptidase A1	Homo sapiens	30-33
33848730-7	2021	In addition, NO release from CPA is triggered by decomposition of L-Arg in the H2O2-rich and acidic tumor microenvironment, permitting localized NO gas therapy in the tumor site.	Arginine	66-71	carboxypeptidase A1	Homo sapiens	29-32
34023918-3	2021	Here, we use functional investigation of CFTR to show that a nearby arginine (R134) plays a functionally analogous role.	Arginine	68-76	CF transmembrane conductance regulator	Homo sapiens	41-45
34050775-5	2021	The IR binding assay was used to determine unknown amounts of insulin secreted by MIN6 beta cell line after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.	Arginine	134-142	insulin	Homo sapiens	62-69
34050775-7	2021	We observed the stimulation of glucose-induced insulin secretion from MIN6 cells by arginine, weaker stimulation by ornithine, but inhibitory effects of dopamine.	Arginine	84-92	insulin	Homo sapiens	47-54
34037752-4	2022	METHODS: We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous measurement of circulating GDF-8 and GDF-11 that employs denaturation, reduction and alkylation; cation-exchange solid-phase extraction; tryptic digestion; followed by separation and quantification using two signature peptides for MRM and C-terminal [ 13C6  15N4]-Arg peptides as internal standards.	Arginine	370-373	myostatin	Homo sapiens	133-138
34020248-7	2021	Interestingly, the chronic administration of a combination of firibastat with [Enalapril+HCTZ] reduced plasma arginine-vasopressin levels by 62% relative to those measured in DOCA-salt rats receiving bitherapy.	Arginine	110-118	arginine vasopressin	Rattus norvegicus	119-130
33989303-2	2021	Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes the symmetric di-methylation of arginine residues, is frequently overexpressed and dysregulated in both human solid and hematologic malignancies.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
34001852-2	2021	Protein arginine methyltransferase 6 (PRMT6) is an epigenetic regulator of gene expression mainly through methylating arginines at histone H3.	Arginine	118-127	protein arginine methyltransferase 6	Homo sapiens	0-36
34001852-2	2021	Protein arginine methyltransferase 6 (PRMT6) is an epigenetic regulator of gene expression mainly through methylating arginines at histone H3.	Arginine	118-127	protein arginine methyltransferase 6	Homo sapiens	38-43
33999432-5	2021	PRMT1 methylates several arginine residues in the C-terminal nuclear/nucleolar localization sequence (NLS/NoLS) of p14ARF .	Arginine	25-33	cyclin dependent kinase inhibitor 2A	Homo sapiens	115-121
33999432-6	2021	In the absence of cellular stress, these arginines are crucial for nucleolar localization of p14ARF .	Arginine	41-50	cyclin dependent kinase inhibitor 2A	Homo sapiens	93-99
33999432-7	2021	Genotoxic stress causes augmented interaction between PRMT1 and p14ARF , accompanied by arginine methylation of p14ARF .	Arginine	88-96	cyclin dependent kinase inhibitor 2A	Homo sapiens	112-118
33999432-10	2021	Our data reveal that PRMT1-mediated arginine methylation is an important trigger for p14ARF "s stress-induced tumor-suppressive function.	Arginine	36-44	cyclin dependent kinase inhibitor 2A	Homo sapiens	85-91
33962943-5	2021	The alpha5beta1-fibronectin complex revealed simultaneous interactions at the arginine-glycine-aspartate loop, the synergy site, and a newly identified binding site proximal to adjacent to metal ion-dependent adhesion site, inducing the translocation of helix alpha1 to secure integrin opening.	Arginine	78-86	fibronectin 1	Homo sapiens	16-27
33979616-4	2021	Under arginine starvation, ASS1 transcription is induced by ATF4 and CEBPbeta binding to an enhancer within ASS1.	Arginine	6-14	CCAAT enhancer binding protein alpha	Homo sapiens	69-77
33979616-6	2021	Arginine starvation drives global chromatin compaction and repressive histone methylation, which disrupts ATF4/CEBPbeta binding and target gene transcription.	Arginine	0-8	CCAAT enhancer binding protein alpha	Homo sapiens	111-119
33881837-4	2021	After loaded with l-arginine (l-Arg) and sealed with poly(acrylic acid) (PAA), hollow Fe3O4 NPs were fabricated into LPFe3O4 NPs, which could release l-Arg based on pH-responsive PAA and produce nitric oxide (NO) with the help of nitric oxide synthase (iNOS) overexpressed by M1 TAMs, as a result of additional tumor elimination for gas therapy.	Arginine	150-155	nitric oxide synthase 2	Homo sapiens	253-257
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	383-393	interleukin 23 receptor	Mus musculus	18-32
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	383-393	interleukin 23 receptor	Mus musculus	34-40
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	385-388	interleukin 23 receptor	Mus musculus	18-32
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	385-388	interleukin 23 receptor	Mus musculus	34-40
33926963-5	2021	Seven SLAC1-conserved arginines are poised in BdSLAC1 for regulatory interaction with the N-terminal extension.	Arginine	22-31	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	6-11
33910429-3	2021	The developed PBPK model was successful in capturing an increase in exposures of R and S-carvedilol, due to the time-based inhibition of CYP2D6 enzyme caused by paroxetine.Conclusion: The developed model can be used for exploring complex clinical scenarios, where multiple drugs are given concurrently, particularly in diseased populations where no clinical trial data is available.	Arginine	81-82	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	137-143
33421881-8	2021	Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8.	Arginine	0-8	interleukin 6	Homo sapiens	91-95
33421881-8	2021	Arginine and vitamin B6 supplemented into cell culture effectively decreased the levels of IL-6 and IL-8.	Arginine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	100-104
33887226-0	2021	Dual Arginine Recognition of LRRK2 phosphorylated Rab GTPases.	Arginine	5-13	leucine rich repeat kinase 2	Homo sapiens	29-34
33459949-5	2021	The promoting influence of miR-362-3p mimic on the proliferation and the inhibitory effect of miR-362-3p mimic on the apoptosis of H/R-stimulated cardiomyocytes were eliminated by overexpression of ORM1.	Arginine	29-30	orosomucoid 1	Homo sapiens	198-202
33377241-2	2021	During the derivatisation of VB with Ns-MOK-(R)-Pro-OSu at 60 C, the nosyl (Ns) group, which was introduced to protect a phenolic hydroxy group, was released within 30 min to produce MOK-(R)-Pro-VB, which was detected fluorimetrically at 448 nm with an excitation wavelength of 333 nm.	Arginine	44-48	MOK protein kinase	Homo sapiens	40-43
33494955-4	2021	Whole exome sequencing, using DNA from peripheral blood of both brothers, identified a pathogenic variant, c.2776 C > T, p.(Arg 926*) in exon 9 of IQSEC2 (NM 001111125.3).	Arginine	124-127	IQ motif and Sec7 domain ArfGEF 2	Homo sapiens	147-153
33581580-8	2021	In addition, Nrf2 inhibition markedly abrogated GRX2-mediated protective effects against H/R-induced apoptosis, oxidative stress and inflammation.	Arginine	49-50	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
33189476-6	2021	However, steaks from ARG and ARGLYS maintained superior color stability coupled with lower mitochondrial membrane permeability and higher cytochrome c redox stability compared to control (P < 0.05).	Arginine	21-24	cytochrome c, somatic	Homo sapiens	138-150
33951695-5	2021	Moreover, miR-129-5p mimics inhibited reactive oxygen species production and upsurged superoxide dismutase activity in H9c2 cells exposed to H/R, and suppressed H/R-caused massive release of proinflammatory cytokines TNF-alpha and IL-1beta.	Arginine	12-13	tumor necrosis factor	Rattus norvegicus	217-226
33951695-5	2021	Moreover, miR-129-5p mimics inhibited reactive oxygen species production and upsurged superoxide dismutase activity in H9c2 cells exposed to H/R, and suppressed H/R-caused massive release of proinflammatory cytokines TNF-alpha and IL-1beta.	Arginine	12-13	interleukin 1 alpha	Rattus norvegicus	231-239
33711406-1	2021	OBJECTIVE: To examine the biochemical components of multi-species biofilm on the arginine (Arg)-sodium fluoride (NaF) varnish-treated enamel following bacterial pH-cycling.	Arginine	81-89	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33711406-1	2021	OBJECTIVE: To examine the biochemical components of multi-species biofilm on the arginine (Arg)-sodium fluoride (NaF) varnish-treated enamel following bacterial pH-cycling.	Arginine	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	113-116
33711406-4	2021	The experimental and control groups were: 1%, 2%, 4% Arg-NaF, NaF, and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33711406-8	2021	RESULTS: The total carbohydrate content of the biofilm was the lowest for the 2% and 4% Arg-NaF (p < 0.05).	Arginine	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	92-95
33711406-9	2021	Except for 2% Arg-NaF, the biofilm proteins for 4% Arg-NaF were significantly higher than the other groups (p < 0.05).	Arginine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
33711406-9	2021	Except for 2% Arg-NaF, the biofilm proteins for 4% Arg-NaF were significantly higher than the other groups (p < 0.05).	Arginine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
33711406-10	2021	The amyloids for Arg-NaF groups were significantly lower than the controls (p < 0.05).	Arginine	17-20	C-X-C motif chemokine ligand 8	Homo sapiens	21-24
33711406-11	2021	The eDNA for 4% Arg-NaF was significantly higher than the controls (p < 0.05).	Arginine	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	20-23
33711406-12	2021	The 2% and 4% Arg-NaF-treated enamel had increased biofilm Pi and F compared to the NaF-treated enamel (p < 0.05).	Arginine	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	18-21
33711406-13	2021	The proportion of biofilm EPS matrix to bacteria was significantly reduced in Arg-NaF groups compared to the controls (p < 0.05).	Arginine	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	82-85
33711406-14	2021	The dead bacterial proportions of 4% Arg-NaF were significantly higher than the controls (p < 0.05).	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
33711406-15	2021	CONCLUSION: Higher concentrations (i.e. 2%/4%) of Arg in 5% NaF varnish have the potential to modulate the biochemical composition of the biofilm growing on the treated enamel.	Arginine	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Arginine	144-152	fibronectin 1	Homo sapiens	24-26
33465368-11	2021	miR103a-3p promoted demethylation of an arginine residue of GATA3 by down-regulating protein arginine methyltransferase 5 (PRMT5) mRNA.	Arginine	40-48	protein arginine methyltransferase 5	Homo sapiens	85-121
33465368-11	2021	miR103a-3p promoted demethylation of an arginine residue of GATA3 by down-regulating protein arginine methyltransferase 5 (PRMT5) mRNA.	Arginine	40-48	protein arginine methyltransferase 5	Homo sapiens	123-128
33538046-2	2021	Derived from the enzymatic conversion of arginine by several nitric oxide synthases (NOS), NO plays significant roles in neuronal developmental events such as the establishment of dendritic branching or arbors.	Arginine	41-49	nitric oxide synthase 2	Homo sapiens	61-83
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	192-223
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	SET domain containing 6, protein lysine methyltransferase	Homo sapiens	225-230
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Arginine	144-152	fibronectin 1	Homo sapiens	57-59
33931940-5	2021	The characterization of Fn-modified surfaces showed that Fn grating via phosphonate has led to the highest amount of Fn cell-binding site (RGD, arginine, glycine, and aspartate) available on the surface.	Arginine	144-152	fibronectin 1	Homo sapiens	57-59
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	BAG cochaperone 1	Homo sapiens	121-125
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	caspase 3	Homo sapiens	127-132
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	DNA damage regulated autophagy modulator 1	Homo sapiens	134-139
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	WD repeat domain 45	Homo sapiens	179-184
33864889-8	2021	Elevated asymmetric and symmetric dimethylarginine combined with reduced arginine levels compromised endothelial nitric oxide synthase activity and nitric oxide signaling.	Arginine	42-50	nitric oxide synthase 3	Homo sapiens	101-134
33896016-7	2021	Mechanistically, Prmt5, encoding protein arginine methyltransferase 5, which catalyzes SDMA formation from arginine, was highly induced in HCC and identified as a direct MYC target gene.	Arginine	41-49	protein arginine methyltransferase 5	Homo sapiens	17-22
33512531-3	2021	Disease arises from somatic gain-of-function variants at the R201 codon in GNAS, replacing arginine by either cysteine or histidine.	Arginine	91-99	GNAS complex locus	Homo sapiens	75-79
33989998-4	2021	The present study aims to study the effect of charge-specific modification of basic amino acids (Lys, Arg) and guanidination on the interaction of insulin with its receptor using molecular modelling.	Arginine	102-105	insulin	Homo sapiens	147-154
33730849-5	2021	Here, we show that additional attractive interactions between arginine and tripolyphosphate determine the re-entrant condensation and decondensation boundaries of the cationic, intrinsically disordered saliva protein, histatin 5.	Arginine	62-70	histatin 3	Homo sapiens	218-228
33920834-7	2021	The interactions between D77-R280 and T243-TM7 could be related to the functional conformation of CXCR6; alternatively, the interaction between Q195-Q244 and N248 could be related to an inactive state due to the loss of this interaction, and an arginine cage broken in the presence of CXCL16s allows the meta-active state of CXCR6.	Arginine	245-253	C-X-C motif chemokine ligand 16	Homo sapiens	285-291
33852844-0	2021	Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.	Arginine	46-54	protein arginine methyltransferase 6	Homo sapiens	70-75
33872411-4	2021	Protein arginine methyltransferase 5 (PRMT5) functions in concert with the methylosome protein 50 (MEP50) cofactor to catalyze symmetric dimethylation of key arginine resides in histones 3 and 4 which modifies the chromatin environment to alter tumor suppressor and oncogene expression and enhance cancer cell survival.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
33853830-4	2021	Here we report that loss of LKB1 results in increased secretion of the C-X-C motif (CXC) chemokines with an NH2-terminal Glu-Leu-Arg (ELR) motif in premalignant and cancerous cells, as well as in genetically engineered murine models (GEMM) of NSCLC.	Arginine	129-132	serine/threonine kinase 11	Mus musculus	28-32
33730849-7	2021	Hence, we conclude that arginine-phosphate-specific interactions not only regulate solution properties but also influence the conformational ensemble of histatin 5, which is shown to vary with the number of arginine residues.	Arginine	24-32	histatin 3	Homo sapiens	153-163
33857479-8	2021	Binding of these alternative import receptors required arginine residues within FUS-RG/RGG motifs, and was weakened by arginine methylation.	Arginine	55-63	FUS RNA binding protein	Homo sapiens	80-83
33548461-0	2021	In vitro Functional characterization of Androgen Receptor Gene Mutations at Arginine p.856 of the Ligand-Binding-Domain Associated with Androgen Insensitivity Syndrome.	Arginine	76-84	androgen receptor	Homo sapiens	40-57
33591753-1	2021	Protein arginine methyltransferase 6 (PRMT6) catalyzes monomethylation and asymmetric dimethylation of arginine residues in various proteins, plays important roles in biological processes, and is associated with multiple cancers.	Arginine	8-16	protein arginine methyltransferase 6	Homo sapiens	38-43
33591753-5	2021	Notably, the crystal structure of the PRMT6-(R)-2 complex and kinetic studies revealed (R)-2 binds a unique, induced allosteric pocket.	Arginine	44-48	protein arginine methyltransferase 6	Homo sapiens	38-43
33506493-7	2021	KEY RESULTS: We identified a conserved arginine in the beta3-strand that exhibits a non-conserved function in nAChR.	Arginine	39-47	immunoglobulin kappa variable 2D-28	Homo sapiens	55-60
33506493-7	2021	KEY RESULTS: We identified a conserved arginine in the beta3-strand that exhibits a non-conserved function in nAChR.	Arginine	39-47	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	110-115
33506493-8	2021	In alpha4beta2 nAChR, the arginine forms a salt-bridge with an aspartate residue in loop B that is necessary for receptor expression, whereas in alpha7 nAChR, this residue is not stabilised by electrostatic interactions, making its side chain highly mobile.	Arginine	26-34	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	15-20
33506493-10	2021	CONCLUSIONS AND IMPLICATIONS: We conclude that the high mobility of the beta3-strand arginine in the alpha7 nAChR influences agonist binding, and possibly gating network and desensitisation.	Arginine	85-93	immunoglobulin kappa variable 2D-28	Homo sapiens	72-77
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	100-110	myeloperoxidase	Homo sapiens	4-7
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	100-110	nitric oxide synthase 3	Homo sapiens	32-36
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	100-110	nitric oxide synthase 3	Homo sapiens	85-89
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	228-238	myeloperoxidase	Homo sapiens	4-7
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	228-238	nitric oxide synthase 3	Homo sapiens	32-36
33539947-6	2021	The MPO-dependent activation of eNOS occurred despite reduced cellular uptake of the eNOS substrate L-arginine, which involved a decrease in the maximal activity (Vmax), but not substrate affinity (Km), of the major endothelial L-arginine transporter, cationic amino acid transporter-1.	Arginine	228-238	nitric oxide synthase 3	Homo sapiens	85-89
33693729-9	2021	Relative to the CON and CON + H2O2 groups, Arg supplementation resulted in 33.0%-59.2% and 14.6%-37.7% lower (P < 0.05) abundance of proapoptotic, mitophagy, and cytoplasmic cytochrome c protein, respectively.	Arginine	43-46	cytochrome c, somatic	Homo sapiens	174-186
33743287-7	2021	l-arginine pretreatment protects the cells by reducing apoptosis, acidosis, oxidative and nitrosative stress, arginase activity and AGE accumulation.	Arginine	0-10	renin binding protein	Homo sapiens	132-135
33675123-1	2021	Protein arginine methyltransferase 5 (PRMT5) is a type of methyltransferase enzyme that can catalyse arginine methylation of histones and non-histone proteins.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
33683322-7	2021	Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing angiotensin 1-7 and activating the MasR while blocking angiotensin III formation, contributes to the antihypertensive effect and the decrease in arginine-vasopressin release induced by RB150/firibastat.	Arginine	300-308	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	190-194
33548859-6	2021	Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation).	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	65-98
33548859-6	2021	Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation).	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	100-104
33548859-6	2021	Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation).	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	144-148
33548859-6	2021	Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation).	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	144-148
33548859-6	2021	Another mechanism is the progressive inhibition of the placental endothelial nitric oxide synthase (eNOS) by oxidative stress, which results in eNOS uncoupling via several events such as a depletion of the eNOS substrate L-arginine due to increased arginase activity, an oxidation of the eNOS cofactor tetrahydrobiopterin (BH4), or eNOS post-translational modifications (for instance by S-glutathionylation).	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	144-148
33625212-6	2021	Subsequently, the classic inducible nitric oxide synthase (iNOS) pathway aroused by immune response was revolutionarily utilized to oxidize the l-arginine substrates for NO production, the process for which could also be promoted by the high reactive oxygen species level generated by chemo-PTT.	Arginine	144-154	nitric oxide synthase 2	Homo sapiens	26-57
33625212-6	2021	Subsequently, the classic inducible nitric oxide synthase (iNOS) pathway aroused by immune response was revolutionarily utilized to oxidize the l-arginine substrates for NO production, the process for which could also be promoted by the high reactive oxygen species level generated by chemo-PTT.	Arginine	144-154	nitric oxide synthase 2	Homo sapiens	59-63
33745155-5	2021	Increased arginine-vasopressin expression and corticosterone levels were observed only at P21.	Arginine	10-18	arginine vasopressin	Rattus norvegicus	19-30
33758287-6	2021	Molecular dynamics simulations suggested that the Arg additive interacts with specific residues of FUS, thereby inhibiting the cation-pi and electrostatic interactions between the FUS molecules.	Arginine	50-53	FUS RNA binding protein	Homo sapiens	99-102
33758287-6	2021	Molecular dynamics simulations suggested that the Arg additive interacts with specific residues of FUS, thereby inhibiting the cation-pi and electrostatic interactions between the FUS molecules.	Arginine	50-53	FUS RNA binding protein	Homo sapiens	180-183
33758287-7	2021	Second, we observed that Arg polymers promote FUS droplet formation, unlike Arg monomers, by bridging the FUS molecules.	Arginine	25-28	FUS RNA binding protein	Homo sapiens	46-49
33758287-7	2021	Second, we observed that Arg polymers promote FUS droplet formation, unlike Arg monomers, by bridging the FUS molecules.	Arginine	25-28	FUS RNA binding protein	Homo sapiens	106-109
33758287-8	2021	Third, we found that the Arg additive suppressed solid aggregate formation of FUS, while Arg polymer enhanced it.	Arginine	25-28	FUS RNA binding protein	Homo sapiens	78-81
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	chromodomain helicase DNA binding protein 4	Homo sapiens	18-22
33653952-4	2021	We report that the p53 mutant R248Q (R, arginine; Q, glutamine) forms, both in cancer cells and in solutions, a condensate with unique properties, mesoscopic protein-rich clusters.	Arginine	40-48	tumor protein p53	Homo sapiens	19-22
33539787-6	2021	EPZ020411, a specific small-molecule inhibitor for PRMT6, suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.	Arginine	74-82	protein arginine methyltransferase 6	Homo sapiens	51-56
33539787-6	2021	EPZ020411, a specific small-molecule inhibitor for PRMT6, suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.	Arginine	74-82	regulator of chromosome condensation 1	Homo sapiens	69-73
33783993-5	2021	In this conjugate, DNA aptamer selected against PDAC cell line confers the function of specifically recognizing and binding to the PDAC cells and activated pancreatic stellate cells (PSCs) in stroma; cell penetrating peptide (Arg)9 facilitates the intracellular delivery of fused proteins; SH2 superbinder conducts the drastic blockade of multiple phosphotyrosines (pY)-based signaling pathways in tumor cells.	Arginine	226-229	sperm hammerhead 2	Mus musculus	290-293
33783993-12	2021	RESULTS: XQ-2d-His-SH2 CM-(Arg)9 conjugate restrained proliferation, invasion, and metastasis of PDAC cells with potent efficacy via blocking the activity of several pY-related signaling cascades.	Arginine	27-31	sperm hammerhead 2	Mus musculus	19-22
33411976-0	2021	Cytoplasmic granule formation by FUS-R495X is attributable to arginine methylation in all Gly-rich, RGG1 and RGG2 domains.	Arginine	62-70	FUS RNA binding protein	Homo sapiens	33-36
33492002-4	2021	RECENT FINDINGS: Cells harboring splicing factor mutations have increased aberrant splicing leading to R-loop formation and cell cycle stalling that create dependencies on Checkpoint kinase 1 (CHK1) activation and canonical splicing maintained by protein arginine methyltransferase activity.	Arginine	255-263	checkpoint kinase 1	Homo sapiens	172-191
33492002-4	2021	RECENT FINDINGS: Cells harboring splicing factor mutations have increased aberrant splicing leading to R-loop formation and cell cycle stalling that create dependencies on Checkpoint kinase 1 (CHK1) activation and canonical splicing maintained by protein arginine methyltransferase activity.	Arginine	255-263	checkpoint kinase 1	Homo sapiens	193-197
33459381-4	2021	Mouse embryonic stem cells (mESCs) expressing arginine methylation-deficient METTL14 exhibit significantly reduced global m6 A levels.	Arginine	46-54	methyltransferase like 14	Mus musculus	77-84
33459381-5	2021	Transcriptome-wide m6 A analysis identified 1,701 METTL14 arginine methylation-dependent m6 A sites located in 1,290 genes involved in various cellular processes, including stem cell maintenance and DNA repair.	Arginine	58-66	methyltransferase like 14	Mus musculus	50-57
33459381-6	2021	These arginine methylation-dependent m6 A sites are associated with enhanced translation of genes essential for the repair of DNA interstrand crosslinks; thus, METTL14 arginine methylation-deficient mESCs are hypersensitive to DNA crosslinking agents.	Arginine	6-14	methyltransferase like 14	Mus musculus	160-167
33459381-6	2021	These arginine methylation-dependent m6 A sites are associated with enhanced translation of genes essential for the repair of DNA interstrand crosslinks; thus, METTL14 arginine methylation-deficient mESCs are hypersensitive to DNA crosslinking agents.	Arginine	168-176	methyltransferase like 14	Mus musculus	160-167
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	29-37	argininosuccinate synthase 1	Bos taurus	195-223
33373331-3	2021	Argininosuccinate lyase (ASL) is the only mammalian enzyme capable of synthesizing arginine, the sole precursor for nitric oxide synthase (NOS)-dependent NO synthesis.	Arginine	83-91	nitric oxide synthase 2	Homo sapiens	116-137
33657586-2	2021	Arginase competes with NO synthase (NOS) for L-arginine, and its upregulation may reduce NOS-derived NO formation or induce production of reactive oxygen species (ROS) via uncoupling of NOS, resulting in endothelial dysfunction.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	23-34
33755849-7	2021	Induction of MI/R model resulted in cardiac dysfunction, oxidative stress, increased activity of RIPK1-RIPK3-MLKL axis and RhoA/ROCK pathway, extension of fibrosis and heart tissue damage.	Arginine	16-17	mixed lineage kinase domain like pseudokinase	Rattus norvegicus	109-113
33995950-4	2021	Materials and Methods: In the current study, different sequences of cell-penetrating peptides (CPPs) containing tryptophan, lysine, and arginine and their nano-complexes were synthesized and their impact on the expression and activity of the ABCB1 gene was evaluated in the A549 lung carcinoma cell line.	Arginine	136-144	ATP binding cassette subfamily B member 1	Homo sapiens	242-247
32720093-2	2021	Most studies use the growth-hormone-releasing hormone plus arginine (GHRH-arginine) test.	Arginine	59-67	growth hormone releasing hormone	Homo sapiens	69-73
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	74-82	argininosuccinate synthase 1	Bos taurus	195-223
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	138-148	argininosuccinate synthase 1	Bos taurus	195-223
33630211-0	2021	Arginine Regulates NLRP3 Inflammasome Activation Through SIRT1 in Vascular Endothelial Cells.	Arginine	0-8	NLR family pyrin domain containing 3	Homo sapiens	19-24
33576751-1	2021	Electrochemical and spectroscopic studies demonstrated that the N-truncated amyloid beta peptide Abeta5-9 (Arg-His-Asp-Ser-Gly-NH2) possessing histidine at position 2 (His-2) formed ternary complexes with copper(ii) and phosphate anions or phosphate groups of biomolecules.	Arginine	107-110	histatin 3	Homo sapiens	168-173
33639734-2	2021	In the present work, extensive atomistic molecular dynamics simulations were performed to investigate the hydration properties of aqueous solutions of concentrated arginine, histidine, and lysine and their comparative efficiency on regulating the conformational stability of the insulin monomer.	Arginine	164-172	insulin	Homo sapiens	279-286
33639734-5	2021	We observed that while the salt bridges formed by the lysine as an additive contributed more toward the direct interactions with insulin, the cation-pi was more prominent for the insulin-arginine interactions.	Arginine	187-195	insulin	Homo sapiens	179-186
33639734-6	2021	Importantly, it was observed that the preferentially more excluded arginine, compared to histidine and lysine from the insulin surface, enriches the hydration layer of the protein.	Arginine	67-75	insulin	Homo sapiens	119-126
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Arginine	73-81	insulin	Homo sapiens	62-69
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Arginine	73-81	insulin	Homo sapiens	312-319
33639734-7	2021	Our study reveals that the loss of configurational entropy of insulin in arginine solution, as compared to that in pure water, is more as compared to the entropy loss in the other two amino acid solutions, which, moreover, was found to be due to the presence of motionally bound less entropic hydration water of insulin in arginine solution than in histidine or lysine solution.	Arginine	323-331	insulin	Homo sapiens	62-69
33637050-9	2021	DTG also achieved greater increase in CD4+ cells from baseline compared to EFV [32.6(10.7,54.7)], ritonavir-boosted darunavir [DRV/r:25.7(3.6,48.1)] and BIC [24.7(1.5,47.7)].	Arginine	19-20	CD4 molecule	Homo sapiens	38-41
33533925-0	2021	A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol.	Arginine	9-17	primase and DNA directed polymerase	Homo sapiens	86-93
33630211-3	2021	In this study, we aimed to confirm the modulatory effect of Arg on NLRP3 inflammasome and the underlying mechanisms in vascular endothelial cells (ECs).	Arginine	60-63	NLR family pyrin domain containing 3	Homo sapiens	67-72
33630211-4	2021	Arg suppressed NLRP3 inflammasome activation in ECs stimulated with lipopolysaccharide (LPS) and adenosine triphosphate (ATP).	Arginine	0-3	NLR family pyrin domain containing 3	Homo sapiens	15-20
33630211-6	2021	Importantly, knockdown of SIRT1 abolished the inhibitory potential of Arg on the activation of NLRP3 inflammasome.	Arginine	70-73	NLR family pyrin domain containing 3	Homo sapiens	95-100
33630211-8	2021	In addition, Arg may regulate NLRP3 inflammasome activation partly through suppression of ROS production.	Arginine	13-16	NLR family pyrin domain containing 3	Homo sapiens	30-35
33630211-9	2021	In combination, we speculate that Arg exerts an inhibitory effect on the activation of NLRP3 inflammasome in ECs, which may be partly mediated by SIRT1 and ROS.	Arginine	34-37	NLR family pyrin domain containing 3	Homo sapiens	87-92
33471524-2	2021	Nevertheless, thrombin cleaves peptide chains solely after Arg, and trypsin after Lys and Arg.	Arginine	59-62	coagulation factor II, thrombin	Homo sapiens	14-22
33624332-2	2021	Several proteins have been reported to act as adaptor proteins which recruit substrate proteins to the active site of PRMT5 for methylation of arginine residues.	Arginine	143-151	protein arginine methyltransferase 5	Homo sapiens	118-123
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	paraoxonase 1	Mus musculus	125-138
33594058-8	2021	Significantly, AKT and RNF167-mediated CASTOR1 degradation activates mTORC1 independent of arginine and promotes breast cancer progression.	Arginine	91-99	AKT serine/threonine kinase 1	Homo sapiens	15-18
33580145-8	2021	FUS(R495X) uses its C-terminal tandem arginine-glycine-glycine regions, RGG2 and RGG3, to bind the PY-NLS binding site of Kapbeta2 for nuclear localization in cells when arginine methylation is inhibited.	Arginine	38-46	FUS RNA binding protein	Homo sapiens	0-3
33580145-8	2021	FUS(R495X) uses its C-terminal tandem arginine-glycine-glycine regions, RGG2 and RGG3, to bind the PY-NLS binding site of Kapbeta2 for nuclear localization in cells when arginine methylation is inhibited.	Arginine	170-178	FUS RNA binding protein	Homo sapiens	0-3
34026434-0	2021	PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.	Arginine	42-50	protein arginine methyltransferase 5	Homo sapiens	0-5
34026434-0	2021	PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.	Arginine	42-50	signal transducer and activator of transcription 3	Homo sapiens	21-26
34026434-0	2021	PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7.	Arginine	42-50	SMAD family member 7	Homo sapiens	78-83
34026434-1	2021	Protein arginine methyltransferase 5 (PRMT5) is the type II arginine methyltransferase that catalyzes the mono- and symmetrical dimethylation of protein substrates at the arginine residues.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
34026434-7	2021	Mechanistically, PRMT5 binds to and methylates Smad7 on Arg-57, enhances Smad7 binding to IL-6 co-receptor gp130, and consequently ensures robust STAT3 activation.	Arginine	56-59	protein arginine methyltransferase 5	Homo sapiens	17-22
34026434-7	2021	Mechanistically, PRMT5 binds to and methylates Smad7 on Arg-57, enhances Smad7 binding to IL-6 co-receptor gp130, and consequently ensures robust STAT3 activation.	Arginine	56-59	SMAD family member 7	Homo sapiens	47-52
33508935-2	2021	In the human population, the two most common ZnT8 variants carry an arginine (R325) or a tryptophan (W325) in position 325.	Arginine	68-76	solute carrier family 30 member 8	Homo sapiens	45-49
33680983-4	2020	Availability of L-Arginine, a semi-essential amino acid is required for inducible nitric oxide synthase (iNOS) mediated NO production.	Arginine	16-26	nitric oxide synthase 2	Homo sapiens	72-103
33680983-4	2020	Availability of L-Arginine, a semi-essential amino acid is required for inducible nitric oxide synthase (iNOS) mediated NO production.	Arginine	16-26	nitric oxide synthase 2	Homo sapiens	105-109
33680983-5	2020	However, arginase is another enzyme, which if expressed concomitantly, may strongly compete for L-Arginine, and suppress NO production by iNOS.	Arginine	96-106	nitric oxide synthase 2	Homo sapiens	138-142
33596708-3	2021	Moreover, postoperative infection is an important factor affecting bone healing.AcN-RADARADARADARADA-CONH2 (RADA) is a new type of self-assembling peptide(SAP) composed of Arg,Ala,Asp and other amino acids was designed and prepared.	Arginine	172-175	SH2 domain containing 1A	Homo sapiens	155-158
33574439-9	2021	In addition, supplementation of L-arginine to DDAH-1-/- rats was used to explore its role in regulating NO.	Arginine	32-42	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	46-52
33152393-5	2021	In this study, to improve gene delivery efficiency, histidine and arginine were conjugated on the primary amines of PG2, synthesizing PG2HR.	Arginine	66-74	delta like non-canonical Notch ligand 1	Homo sapiens	116-119
33152393-6	2021	The gene delivery efficiency of PG2HR was higher than that of PG2 or of PG2 conjugated with only arginine (PG2R), which may be due to higher cellular uptake and endosomal escape of the plasmid DNA (pDNA)/PG2HR complex.	Arginine	97-105	delta like non-canonical Notch ligand 1	Homo sapiens	32-35
34027271-13	2021	C3a and C5a play a role in this liver-lung and liver-adipose interaction in alcohol-fed mice deficient in liver arginine methylation.	Arginine	112-120	hemolytic complement	Mus musculus	8-11
33571523-7	2021	Computational modeling suggested two amino acids in alpha7-nAChRs, arginine 208 and glutamate 211, were important for the interaction between Abeta and alpha7-containing nAChRs.	Arginine	67-75	amyloid beta precursor protein	Homo sapiens	142-147
33559459-7	2021	Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group.	Arginine	106-111	myeloperoxidase	Homo sapiens	202-205
33575089-6	2021	Knockdown of HIF1alpha reduced the expression of nNOS and P4HA1, the concentration of NO and the invasiveness of cells, while increased the concentration of L-Arg.	Arginine	157-162	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-22
33556161-2	2021	Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues and is overexpressed in GBM.	Arginine	87-95	protein arginine methyltransferase 5	Homo sapiens	0-36
33556161-2	2021	Protein Arginine Methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues and is overexpressed in GBM.	Arginine	87-95	protein arginine methyltransferase 5	Homo sapiens	38-43
33127435-5	2021	Even though TGF-beta1 has been shown to participate in ER stress, its regulatory effect on CF apoptosis and ER stress-induced by sI/R or TN has not been evaluated yet.	Arginine	56-57	transforming growth factor, beta 1	Rattus norvegicus	12-21
33536412-2	2021	In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the expansion of the fusion pore and thereby the concentration of neurotransmitter released.	Arginine	17-25	secretoglobin family 2B member 3, pseudogene	Homo sapiens	88-91
33536412-5	2021	These data indicate that the C2B domain has at least two distinct molecular roles in the fusion event, and the data are consistent with a model where the arginine apex of C2B positions the domain at the curved membrane surface of the expanding fusion pore.	Arginine	154-162	secretoglobin family 2B member 3, pseudogene	Homo sapiens	29-32
33536412-5	2021	These data indicate that the C2B domain has at least two distinct molecular roles in the fusion event, and the data are consistent with a model where the arginine apex of C2B positions the domain at the curved membrane surface of the expanding fusion pore.	Arginine	154-162	secretoglobin family 2B member 3, pseudogene	Homo sapiens	171-174
33189785-6	2021	Substitution of two putative phylogenetically well-conserved small ubiquitin-like modifier (SUMO) acceptor sites, lysine 102 (K102) and 577 (K577) by arginine residues (R) modulated Nur77 transcriptional activity.	Arginine	150-158	nuclear receptor subfamily 4 group A member 1	Homo sapiens	182-187
33221341-2	2021	Arginine scanning of the six CDR loops of U33 was done to identify initial binding determinants since uPA prefers arginine in its primary substrate binding pocket.	Arginine	0-8	plasminogen activator, urokinase	Homo sapiens	102-105
33221341-2	2021	Arginine scanning of the six CDR loops of U33 was done to identify initial binding determinants since uPA prefers arginine in its primary substrate binding pocket.	Arginine	114-122	plasminogen activator, urokinase	Homo sapiens	102-105
33469838-2	2021	Arginine methylation by PRMT5 has been implicated in gene transcription, ribosome biogenesis, RNA transport, pre-mRNA splicing and signal transduction.	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	24-29
33355364-11	2021	Furthermore, Ad-hTK1/hTIMP1 significantly enhanced proliferation, migration and tube formation in H/R-treated CMVECs.	Arginine	100-101	thymidine kinase 1	Homo sapiens	16-20
33355364-11	2021	Furthermore, Ad-hTK1/hTIMP1 significantly enhanced proliferation, migration and tube formation in H/R-treated CMVECs.	Arginine	100-101	TIMP metallopeptidase inhibitor 1	Homo sapiens	21-27
33832413-1	2021	L-arginine is a key metabolite for nitric oxide production by endothelial cells, as well as signaling molecule of the mTOR signaling pathway.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	118-122
33832413-2	2021	mTOR supports endothelial cells homeostasis and regulates activity of L-arginine-metabolizing enzymes, endothelial nitric oxide synthase, and arginase II.	Arginine	70-80	mechanistic target of rapamycin kinase	Homo sapiens	0-4
33127435-12	2021	In conclusion, TGF-beta1 partially protects CF apoptosis induced by sI/R or Tn, through a mechanism that would involve ER stress.	Arginine	71-72	transforming growth factor, beta 1	Rattus norvegicus	15-24
33747724-4	2021	Mechanistically, PADI2 interacting and catalyzing MEK1 citrullination at arginine 113/189 facilitates MEK1 on extracellular signal-regulated protein kinases 1/2 (ERK1/2) phosphorylation, which activates insulin-like growth factor-II binding protein 1 (IGF2BP1) expression.	Arginine	73-81	mitogen-activated protein kinase 3	Homo sapiens	162-168
33466626-7	2021	FN3K is a unique protein that mediates deglycation by phosphorylating basic amino acids lysine and arginine in various proteins such as Nrf2.	Arginine	99-107	fructosamine 3 kinase	Homo sapiens	0-4
33495423-5	2021	Furthermore, recombinant murine IL-22 (rIL-22) was administrated to L-arginine-induced SAP mice by intraperitoneal injection.	Arginine	68-78	interleukin 22	Rattus norvegicus	39-45
33495423-10	2021	Furthermore, Larginine- induced SAP was attenuated by rIL-22 treatment.	Arginine	13-22	interleukin 22	Rattus norvegicus	54-60
33495423-14	2021	Conclusions: Exogenous rIL-22 attenuates L-arginine-induced acute pancreatitis and intestinal mucosa injury in mice, via activating STAT3 signaling pathway and enhancing the expression of antimicrobial peptides and antiapoptotic genes.	Arginine	41-51	interleukin 22	Rattus norvegicus	23-29
33495423-14	2021	Conclusions: Exogenous rIL-22 attenuates L-arginine-induced acute pancreatitis and intestinal mucosa injury in mice, via activating STAT3 signaling pathway and enhancing the expression of antimicrobial peptides and antiapoptotic genes.	Arginine	41-51	signal transducer and activator of transcription 3	Mus musculus	132-137
33495566-1	2021	Protein arginine methyltransferase 3 (PRMT3) regulates protein functions by introducing asymmetric dimethylation marks at the arginine residues in proteins.	Arginine	8-16	protein arginine methyltransferase 3	Homo sapiens	38-43
33499404-1	2021	Nitric oxide (NO) is formed during the oxidation of L-arginine to L-citrulline by the action of multiple isoenzymes of NO synthase (NOS): neuronal NOS (nNOS), endotelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	119-130
33472061-1	2021	The chromatin-associated protein WDR5 is a promising pharmacological target in cancer, with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called the WIN site.	Arginine	140-148	WD repeat domain 5	Homo sapiens	33-37
33472061-1	2021	The chromatin-associated protein WDR5 is a promising pharmacological target in cancer, with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called the WIN site.	Arginine	140-148	WD repeat domain 5	Homo sapiens	167-171
33307682-8	2021	Computational modeling identified a likely mode of interaction of the negatively charged side chain in GLP-1-CYA with an arginine on GLP-1R.	Arginine	121-129	glucagon	Homo sapiens	103-108
33144068-1	2021	We investigated the role of protein arginine methylation (PAM) in estrogen receptor (ER)-positive breast cancer cells through pharmacological intervention.	Arginine	36-44	estrogen receptor 1	Homo sapiens	66-83
33144068-1	2021	We investigated the role of protein arginine methylation (PAM) in estrogen receptor (ER)-positive breast cancer cells through pharmacological intervention.	Arginine	36-44	estrogen receptor 1	Homo sapiens	85-87
33664859-1	2021	Background: Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that symmetrically di-methylates arginine residues on both histone and non-histone protein substrates.	Arginine	20-28	protein arginine methyltransferase 5	Homo sapiens	50-55
33574759-8	2020	Taken together, our data indicated that Arctigenin reduced cardiomyocytes apoptosis against AMI/R-induced oxidative stress and inflammation at least via AMPK/SIRT1 pathway.	Arginine	96-97	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	153-157
33574759-8	2020	Taken together, our data indicated that Arctigenin reduced cardiomyocytes apoptosis against AMI/R-induced oxidative stress and inflammation at least via AMPK/SIRT1 pathway.	Arginine	96-97	sirtuin 1	Rattus norvegicus	158-163
33406258-8	2021	Functionally, a CtIP mutant where K578 is substituted with a non-SUMOylatable arginine residue is defective in promoting DNA end resection, homologous recombination, and in protecting stalled replication forks from excessive nucleolytic degradation.	Arginine	78-86	RB binding protein 8, endonuclease	Homo sapiens	16-20
33644712-3	2021	c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation.	Arginine	6-9	interferon gamma	Homo sapiens	117-125
33495408-10	2021	Furthermore, CARM1 regulates arginine methylation of Smad7, activates the TGF-beta/Smad pathway and induces epithelial-to-mesenchymal transition (EMT), thereby promoting SCLC chemoresistance.	Arginine	29-37	SMAD family member 7	Homo sapiens	53-58
33495408-10	2021	Furthermore, CARM1 regulates arginine methylation of Smad7, activates the TGF-beta/Smad pathway and induces epithelial-to-mesenchymal transition (EMT), thereby promoting SCLC chemoresistance.	Arginine	29-37	SMAD family member 7	Homo sapiens	53-57
33038288-2	2021	Reduction yielded the corresponding 2-aza-1,3-diphospha-indane-1,3-diyls ( 1 ), which can be described as phosphorus-centered singlet biradical(oid)s. Their stability depends on the size of the substituent R: While derivatives with R = Dmp (2,6-dimethylphenyl) or Ter (2,6-dimesitylphenyl) underwent oligomerisation, the derivative with very bulky R = t Bu Bhp (2,6-bis(benzhydryl)-4-tertbutylphenyl) was stable with respect to oligomerisation in its monomeric form.	Arginine	0-1	trans-2,3-enoyl-CoA reductase	Homo sapiens	264-267
33038288-2	2021	Reduction yielded the corresponding 2-aza-1,3-diphospha-indane-1,3-diyls ( 1 ), which can be described as phosphorus-centered singlet biradical(oid)s. Their stability depends on the size of the substituent R: While derivatives with R = Dmp (2,6-dimethylphenyl) or Ter (2,6-dimesitylphenyl) underwent oligomerisation, the derivative with very bulky R = t Bu Bhp (2,6-bis(benzhydryl)-4-tertbutylphenyl) was stable with respect to oligomerisation in its monomeric form.	Arginine	206-207	trans-2,3-enoyl-CoA reductase	Homo sapiens	264-267
33183638-0	2021	Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin for oral insulin delivery.	Arginine	51-59	insulin	Homo sapiens	110-117
33183638-4	2021	In this study, a novel N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin (NAC-HP-beta-CD-Arg) was successfully synthesized and characterized.	Arginine	47-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	105-112
33466626-7	2021	FN3K is a unique protein that mediates deglycation by phosphorylating basic amino acids lysine and arginine in various proteins such as Nrf2.	Arginine	99-107	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
33488621-2	2020	Here, we develop a simple platform using a conserved human melanoma peptide antigen (Trp2) modified with cationic arginine residues that condenses an anionic toll-like receptor agonist (TLRa), CpG, into polyplex-like nanoparticles.	Arginine	114-122	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	85-89
33423701-10	2021	In conclusion, here we identify, for the first time, an autophagy-mediated inhibition of RhoA that plays an important role in regulating ovarian cancer cells motility and adhesion in response to arginine depletion.	Arginine	195-203	ras homolog family member A	Homo sapiens	89-93
33413061-3	2021	While the exact mechanisms of endothelial dysfunction in RA remain to be established, there is good evidence that RA patients have relatively high circulating concentrations of the methylated arginine asymmetric dimethylarginine (ADMA), a potent endogenous inhibitor of endothelial NO synthase (eNOS).	Arginine	192-200	nitric oxide synthase 3	Homo sapiens	295-299
33423701-9	2021	In addition, we were able to establish through pull-down assays and reversal experiments, that arginine deprivation-mediated autophagy inhibits cell migration through a direct inhibition of RhoA, member of the Rho family of GTPases.	Arginine	95-103	ras homolog family member A	Homo sapiens	190-194
33419170-6	2021	In contrast, the genes that maintain mitochondrial functions and neuronal survival, including Hba-a2 and Hbb-b2, were significantly increased in mice that ingested Arg.	Arginine	164-167	hemoglobin alpha, adult chain 2	Mus musculus	94-100
33488621-5	2020	We show antigen loading can be tuned by interchanging Trp2 peptides with defined charges and numbers of arginine residues.	Arginine	104-112	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	54-58
33443146-1	2021	The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway of protein degradation.	Arginine	182-185	arginyltransferase 1	Mus musculus	14-18
33402116-11	2021	We found that miR-205, one of the DEMs, was negatively regulated the expression of ARG (NKX2-3).	Arginine	83-86	NK2 homeobox 3	Homo sapiens	88-94
33402116-18	2021	MiR-205 was negatively regulated the expression of ARG (NKX2-3).	Arginine	51-54	NK2 homeobox 3	Homo sapiens	56-62
33443146-1	2021	The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway of protein degradation.	Arginine	182-185	arginyltransferase 1	Mus musculus	120-154
33443146-1	2021	The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway of protein degradation.	Arginine	182-185	arginyltransferase 1	Mus musculus	156-160
33315404-0	2021	Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates.	Arginine	29-31	ATP binding cassette subfamily B member 1	Homo sapiens	62-76
33096224-0	2021	Insulin requires A2B adenosine receptors to modulate the L-arginine/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia.	Arginine	57-67	insulin	Homo sapiens	0-7
32328671-9	2021	Our data indicate that MAF interfere with intracellular CTL signaling via soluble mediators leading to CTL anergy and modify immune checkpoint receptor availability via L-arginine depletion.	Arginine	169-179	MAF bZIP transcription factor	Homo sapiens	23-26
33096224-14	2021	Thus, LOPE alters endothelial function, causing an imbalance in the L-arginine/NO signalling pathway to reduce the umbilical vein dilation to insulin requiring A2BAR activation in HUVECs.	Arginine	68-78	insulin	Homo sapiens	142-149
33202281-0	2021	Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.	Arginine	24-34	sirtuin 1	Rattus norvegicus	66-71
33202281-0	2021	Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.	Arginine	24-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	72-76
33202281-0	2021	Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis.	Arginine	24-34	tumor necrosis factor	Rattus norvegicus	77-80
33202281-8	2021	RESULTS: l-arginine group displayed AP as manifested by a significant increase in serum lipase and amylase, MDA, NOx, IL-6, TNF-alpha, caspase-3 with iNOS immuno-expression.	Arginine	9-19	tumor necrosis factor	Rattus norvegicus	124-133
33202281-8	2021	RESULTS: l-arginine group displayed AP as manifested by a significant increase in serum lipase and amylase, MDA, NOx, IL-6, TNF-alpha, caspase-3 with iNOS immuno-expression.	Arginine	9-19	nitric oxide synthase 2	Rattus norvegicus	150-154
33758649-5	2021	Specifically, the Arginine 69 residue in the SARS-CoV-2 E-SLiM is the key residue able to both enhance the specific polar interaction with negatively charged pockets of the PALS1 PDZ domain and reduce significantly the mobility of the viral peptide.	Arginine	18-26	PDZ and LIM domain 2	Homo sapiens	58-62
32891986-14	2021	Maternal dietary L-Arg supplementation significantly improved the expression of CPS1 gene, OTC gene (1.16%, 1.35%, and 1.55%), and ASS gene (1.35% and 1.55%) in the liver (P < 0.05), and also enhanced the CPS1 gene (except 1.35%) and OTC gene (1.55% and 1.74%) expression in the breast muscle (P < 0.05).	Arginine	17-22	carbamoyl-phosphate synthase 1	Gallus gallus	80-84
32348225-4	2021	The enzyme nitric oxide synthase (NOS) is responsible for the generation of NO in different cells by conversion of L-arginine (Arg) to L-citrulline.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	11-32
32348225-4	2021	The enzyme nitric oxide synthase (NOS) is responsible for the generation of NO in different cells by conversion of L-arginine (Arg) to L-citrulline.	Arginine	127-130	nitric oxide synthase 2	Homo sapiens	11-32
32891986-14	2021	Maternal dietary L-Arg supplementation significantly improved the expression of CPS1 gene, OTC gene (1.16%, 1.35%, and 1.55%), and ASS gene (1.35% and 1.55%) in the liver (P < 0.05), and also enhanced the CPS1 gene (except 1.35%) and OTC gene (1.55% and 1.74%) expression in the breast muscle (P < 0.05).	Arginine	17-22	carbamoyl-phosphate synthase 1	Gallus gallus	205-209
33043402-10	2021	Diphtheria toxin-induced knockdown of glucagon producing cells led to reduced somatostatin secretion in response to 12 mmol/l glucose and arginine infusions.	Arginine	138-146	somatostatin	Mus musculus	78-90
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
33043402-12	2021	However, infusion of exendin 9-39 in Gcgr-/- mice completely abolished somatostatin secretion in response to glucose and arginine.	Arginine	121-129	somatostatin	Mus musculus	71-83
33320105-8	2021	The beneficial effects of H/R treatment were mechanistically mediated via the restoration of Nrf2/HO-1 anti-oxidant signaling pathway in the liver of GDM mice.	Arginine	28-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
33320105-8	2021	The beneficial effects of H/R treatment were mechanistically mediated via the restoration of Nrf2/HO-1 anti-oxidant signaling pathway in the liver of GDM mice.	Arginine	28-29	heme oxygenase 1	Mus musculus	98-102
33320105-9	2021	CONCLUSION: Our study, for the first time, suggests that H/R treatment is a potentially novel therapeutic approach against GDM symptoms, by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.	Arginine	59-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
33320105-9	2021	CONCLUSION: Our study, for the first time, suggests that H/R treatment is a potentially novel therapeutic approach against GDM symptoms, by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.	Arginine	59-60	heme oxygenase 1	Mus musculus	160-164
33391421-1	2021	Introduction: Previous studies have shown that peptides containing the asparagine-glycine-arginine (NGR) sequence can specifically bind to CD13 (aminopeptidase N) receptor, a tumor neovascular biomarker that is over-expressed on the surface of angiogenic blood vessels and various tumor cells, and it plays an important role in angiogenesis and tumor progression.	Arginine	90-98	reticulon 4 receptor	Mus musculus	100-103
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	solute carrier family 7 member 5	Bos taurus	146-152
33188848-15	2021	The Arg-NaF varnish appears a promising caries-preventive regimen that counters the pathogenic biofilms by Arg and promotes remineralization with fluorides.	Arginine	4-7	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33188848-15	2021	The Arg-NaF varnish appears a promising caries-preventive regimen that counters the pathogenic biofilms by Arg and promotes remineralization with fluorides.	Arginine	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	8-11
33868616-6	2021	These R&R structures are composed of inosine monophosphate dehydrogenase type 2 (IMPDH2), and their formation can be induced in vitro by several small-molecule inhibitors.	Arginine	6-7	inosine monophosphate dehydrogenase 2	Homo sapiens	81-87
33868616-6	2021	These R&R structures are composed of inosine monophosphate dehydrogenase type 2 (IMPDH2), and their formation can be induced in vitro by several small-molecule inhibitors.	Arginine	8-9	inosine monophosphate dehydrogenase 2	Homo sapiens	81-87
32654243-9	2021	Arginine increased CAT-1 in the jejunum and ileum under DEX treatment.	Arginine	0-8	solute carrier family 7 member 1	Gallus gallus	19-24
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-4	2021	Experimental and control groups were: 1% Arg-NaF; 2% Arg-NaF; 4% Arg-NaF; NaF and no treatment.	Arginine	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	57-60
33188848-8	2021	RESULTS: Increasing concentrations of Arg in NaF varnish significantly increased the EFU of incipient caries-like lesions (p < 0.001).	Arginine	38-41	C-X-C motif chemokine ligand 8	Homo sapiens	45-48
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	15-18	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33188848-9	2021	The PFU for 1% Arg-NaF was significantly higher than 4% Arg-NaF and the control NaF (p < 0.05).	Arginine	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	60-63
33188848-10	2021	Post pH-cycling, Ca/P ratio with 1%/2% Arg-NaF was closest to hydroxyapatite (1.67).	Arginine	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	43-46
33188848-11	2021	Mineral gain and % remineralization of 1%/2% Arg-NaF was significantly higher than the control NaF varnish (p < 0.05).	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
33129925-4	2021	l-Arginine, the substrate of iNOS, restores the promotion effect of VPA, being against MDLA.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	29-33
33129839-6	2021	In vivo functional parameters of insulin secretion, assessed by hyperglycemic clamp, negatively correlated with the increase in fibers [beta-cell Glucose Sensitivity (r = -0.84; p = 0.01), incremental second-phase insulin secretion (r = -0.84, p = 0.03) and arginine-stimulated insulin secretion (r = -0.76, p = 0.04)].	Arginine	258-266	insulin	Homo sapiens	33-40
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	BCL2, apoptosis regulator	Rattus norvegicus	98-103
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	BCL2, apoptosis regulator	Rattus norvegicus	120-125
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	BCL2, apoptosis regulator	Rattus norvegicus	98-103
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	BCL2, apoptosis regulator	Rattus norvegicus	120-125
34009196-5	2020	Results showed that the combined therapy (HU + L-Arginine) decreased SBP, DBP, MAP and PP (p <0.01 in each case) but increased %HbF, Hb and PCV (p< o.001 in each case).	Arginine	47-57	D-box binding PAR bZIP transcription factor	Homo sapiens	74-77
33457206-6	2021	Arginine at position 72 plays a role in NFS1-ISD11 complex formation; therefore, its substitution with glutamine is expected to affect complex stability and function.	Arginine	0-8	LYR motif containing 4	Homo sapiens	45-50
33376131-1	2021	Protein arginine methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues in various proteins affecting diverse cellular processes such as transcriptional regulation, splicing, DNA repair, differentiation, and cell cycle.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
33357437-6	2020	Arginine-rich DPRs promote phase separation and insolubility of TDP-43 in vitro and in cells, and this pathological interaction is suppressed by elevating importin concentrations.	Arginine	0-8	TAR DNA binding protein	Homo sapiens	64-70
33380261-0	2022	Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5.	Arginine	42-50	protein arginine methyltransferase 5	Homo sapiens	89-94
33380261-2	2022	In this study, we determined how local changes on adjacent residues in the histone H4 substrate regulate arginine asymmetric dimethylation and symmetric dimethylation catalysed by the major protein arginine methyltransferase (PRMT) enzymes PRMT1 and PRMT5, respectively.	Arginine	105-113	protein arginine methyltransferase 5	Homo sapiens	250-255
33169770-1	2020	Water-dispersed gold nanoparticles decorated with an amphiphilic cyclotetrasiloxane scaffold hold promise for the catalytic transformation of diorganosilanes to tetraorganodisiloxane-1,3-diols, (RR1SiOH)2O [R = Me or Ph R1 = Ph, cyclo-Hex] via en route formation of a Pickering emulsion.	Arginine	195-196	pleckstrin homology domain containing B1	Homo sapiens	217-222
33414716-6	2020	NO is produced by the activity of endothelial NO synthase (eNOS) on its substrate, L-arginine.	Arginine	83-93	nitric oxide synthase 3	Homo sapiens	34-57
33414716-6	2020	NO is produced by the activity of endothelial NO synthase (eNOS) on its substrate, L-arginine.	Arginine	83-93	nitric oxide synthase 3	Homo sapiens	59-63
33414716-7	2020	Reduced availability of L-arginine to eNOS has been implicated in vascular dysfunction in diabetes.	Arginine	24-34	nitric oxide synthase 3	Homo sapiens	38-42
33349091-8	2020	In addition, treatment with PMS attenuated H/R-stimulated production of TNF-alpha, IL-6 and IL-1beta in H9c2 cells.	Arginine	45-46	tumor necrosis factor	Rattus norvegicus	72-81
33349091-8	2020	In addition, treatment with PMS attenuated H/R-stimulated production of TNF-alpha, IL-6 and IL-1beta in H9c2 cells.	Arginine	45-46	interleukin 6	Rattus norvegicus	83-87
33349091-8	2020	In addition, treatment with PMS attenuated H/R-stimulated production of TNF-alpha, IL-6 and IL-1beta in H9c2 cells.	Arginine	45-46	interleukin 1 alpha	Rattus norvegicus	92-100
32905759-4	2020	We reveal that the 3,849 + 10 kb C>T-induced CFTR pseudo exon is regulated by phosphorylation of serine/arginine-rich splicing factors, and their functional inhibition by a CDC-like kinase inhibitor restores normal splicing of CFTR.	Arginine	104-112	CF transmembrane conductance regulator	Homo sapiens	45-49
32905759-4	2020	We reveal that the 3,849 + 10 kb C>T-induced CFTR pseudo exon is regulated by phosphorylation of serine/arginine-rich splicing factors, and their functional inhibition by a CDC-like kinase inhibitor restores normal splicing of CFTR.	Arginine	104-112	CF transmembrane conductance regulator	Homo sapiens	227-231
33210935-2	2020	This investigation studied the effect of apocynin, an NADPH oxidase inhibitor and catalase, an H2O2 scavenger on L-arginine induced oxidative stress and hypotension.	Arginine	113-123	catalase	Rattus norvegicus	82-90
33210935-10	2020	Renal Nox4 mRNA activity was approximately 2.1 fold higher (P<0.05) in the L-arginine treated rats but was normalized by apocynin and apocynin plus catalase treatment.	Arginine	75-85	catalase	Rattus norvegicus	148-156
33210935-11	2020	Administration of apocynin and catalase, but not catalase alone to rats fed L-arginine, restored the deranged renal function and structure, prevented hypotension and enhanced the antioxidant capacity and suppressed Nox4 expression.	Arginine	76-86	catalase	Rattus norvegicus	31-39
33339152-0	2020	Physicochemical Characteristics of Arginine Enriched NaF Varnish: An In Vitro Study.	Arginine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
33339152-1	2020	The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release.	Arginine	64-72	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
33339152-1	2020	The in vitro study objectives were to investigate the effect of arginine (Arg) incorporation in a 5% sodium fluoride (NaF) varnish on its physical and chemical properties including F/Arg release.	Arginine	74-77	C-X-C motif chemokine ligand 8	Homo sapiens	118-121
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	81-84	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-4	2020	Molecular dynamics were simulated to identify post-dynamics total energy for NaF=Arg/Arg>NaF/Arg<NaF concentrations.	Arginine	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	77-80
33339152-6	2020	Incorporation of L-Arg in NaF varnish significantly influences physical properties ameliorating retention (p < 0.001).	Arginine	17-22	C-X-C motif chemokine ligand 8	Homo sapiens	26-29
33339152-7	2020	L-Arg in NaF varnish institutes the Arg-F complex.	Arginine	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
33339152-7	2020	L-Arg in NaF varnish institutes the Arg-F complex.	Arginine	2-5	C-X-C motif chemokine ligand 8	Homo sapiens	9-12
33339152-8	2020	Molecular dynamics suggests that NaF>Arg concentration denotes the stabilized environment compared to NaF<Arg (p < 0.001).	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	33-36
33339152-9	2020	The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001).	Arginine	7-10	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
33339152-9	2020	The 2% Arg-NaF exhibits periodic perennial Arg/F release and shows significantly higher integrated mean F release than NaF (p < 0.001).	Arginine	43-46	C-X-C motif chemokine ligand 8	Homo sapiens	11-14
33339152-10	2020	Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control.	Arginine	17-27	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33339152-10	2020	Incorporating 2% L-arginine in 5% NaF varnish improves its physical properties and renders a stable matrix with enduring higher F/Arg release than control.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	34-37
33317692-3	2020	Copeptin, which is a split product of the vasopressin pre-propeptide, appears to be a robust biomarker in the circulation and a promising tool for the diagnosis of patients with polyuria and polydipsia, especially when measured in conjunction with intravenous infusion of arginine, as summarised in this review.	Arginine	272-280	arginine vasopressin	Homo sapiens	0-8
33303990-6	2021	Similar results were observed in L-arg-pretreated cultured endothelial cells, showing markedly decreased ROS accumulation and AKT/eNOS/NO signaling impairment induced by aflibercept.	Arginine	33-38	thymoma viral proto-oncogene 1	Mus musculus	126-129
33229537-5	2020	2) Glucocorticoid receptor (GR), an immunity-modulating transcription factor (TF), is up-regulated in 2-KO cells and also physically binds to UBR1, strongly suggesting that GR is a physiological substrate of the Arg/N-degron pathway.	Arginine	212-215	nuclear receptor subfamily 3 group C member 1	Homo sapiens	3-26
33293536-0	2020	Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.	Arginine	7-15	RuvB like AAA ATPase 1	Homo sapiens	0-6
33229537-5	2020	2) Glucocorticoid receptor (GR), an immunity-modulating transcription factor (TF), is up-regulated in 2-KO cells and also physically binds to UBR1, strongly suggesting that GR is a physiological substrate of the Arg/N-degron pathway.	Arginine	212-215	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-30
33229537-5	2020	2) Glucocorticoid receptor (GR), an immunity-modulating transcription factor (TF), is up-regulated in 2-KO cells and also physically binds to UBR1, strongly suggesting that GR is a physiological substrate of the Arg/N-degron pathway.	Arginine	212-215	nuclear receptor subfamily 3 group C member 1	Homo sapiens	173-175
33109615-8	2020	Among the G12/13 pathway alterations were mutations in Arg-200 of Galpha13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-depedent (SRE.L) transcriptional activity.	Arginine	55-58	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	110-113
33302356-9	2020	In addition, all the DEHP metabolites and testosterone showed a common hydrogen bonding interaction with amino-acid Arg-752 of AR.	Arginine	116-119	androgen receptor	Homo sapiens	127-129
33080171-4	2020	In mammalian embryonic stem cells and cultured neurons, SRPK phosphorylates Ser-Arg motifs in RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual disability syndrome.	Arginine	80-83	ring finger protein, LIM domain interacting	Homo sapiens	94-99
33080171-4	2020	In mammalian embryonic stem cells and cultured neurons, SRPK phosphorylates Ser-Arg motifs in RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual disability syndrome.	Arginine	80-83	ring finger protein, LIM domain interacting	Homo sapiens	100-104
33280590-10	2022	RESULTS: Eight amino acid levels (methionine, arginine, cystine, glutamine, proline, asparagine, serine, aspartate) were significantly altered in patients with neurofibromatosis type 1.	Arginine	46-54	neurofibromin 1	Homo sapiens	160-184
33038622-5	2020	The decreased abundance of two mobile genetic elements and impaired conjugative transfer of RP4 plasmid in the presence of PA, F2 and F3 demonstrated that the weakened horizontal gene transfer (HGT) contributed to the reduced ARG level.	Arginine	226-229	rhodopsin	Homo sapiens	92-95
32163000-6	2020	Four long primer pairs with sticky end were used to synthesize CGA-N12 expression sequence which contains four copies of CGA-N12 flanked by a Lys-Arg pair and two Glu-Ala repeating units.	Arginine	146-149	chromogranin A	Homo sapiens	63-66
32698065-5	2020	We found that 0.13 M histidine, 1.64 M methionine, 0.33 M cysteine, and 0.34 M arginine in addition to the GSH/GSSG is the optimal condition for refolding of reteplase.	Arginine	79-87	plasminogen activator, tissue type	Homo sapiens	158-167
32725514-5	2020	IFN-gamma increased the activity of arginase II and reduced the level of arginine in cells, while the addition of arginine inhibited the expression of TLR4 and CCL5.	Arginine	73-81	interferon gamma	Mus musculus	0-9
32725514-8	2020	These data reveal that increased IFN-gamma reduces arginine levels and activates TLR4-CCL5 signaling, leading to enhanced susceptibility of BMECs to S. aureus.	Arginine	51-59	interferon gamma	Mus musculus	33-42
33248609-4	2020	The proportions of CD3+ and CD4+/CD8+ lymphocytes responded in a linear (P < 0.05) manner and those of CD4+ in a linear or quadratic (P < 0.05) manner as dietary Arg levels increased.	Arginine	162-165	CD3d molecule	Gallus gallus	19-22
33222863-12	2020	The individual AA Leu, Met, Ile, and Arg increased S6K1 phosphorylation in an insulin-dependent manner.	Arginine	37-40	ribosomal protein S6 kinase B1	Bos taurus	51-55
33290139-9	2020	Conclusion: The p53 rs1042522 arg allele together with tobacco smoking and alcohol drinking, was associated with an increased risk, for gastric cancer and EC, but not the survival among northwestern Chinese patients.	Arginine	30-33	tumor protein p53	Homo sapiens	16-19
33380527-4	2020	The ability to measure a stimulated copeptin level, either with hypertonic saline or arginine infusion, has led to greater diagnostic accuracy.	Arginine	85-93	arginine vasopressin	Homo sapiens	36-44
33248609-4	2020	The proportions of CD3+ and CD4+/CD8+ lymphocytes responded in a linear (P < 0.05) manner and those of CD4+ in a linear or quadratic (P < 0.05) manner as dietary Arg levels increased.	Arginine	162-165	T-cell surface glycoprotein CD4	Gallus gallus	103-106
33248609-5	2020	Dietary Arg level had a linear (P < 0.05) or quadratic (P < 0.05) effect on the gene expression of glutathione peroxidase 1, heme oxygenase 1, nuclear factor erythroid 2-related factor 2, and the activities of glutathione peroxidase and total antioxidative capacity in the jejunum and ileum.	Arginine	8-11	glutathione peroxidase 1	Gallus gallus	99-123
33248609-5	2020	Dietary Arg level had a linear (P < 0.05) or quadratic (P < 0.05) effect on the gene expression of glutathione peroxidase 1, heme oxygenase 1, nuclear factor erythroid 2-related factor 2, and the activities of glutathione peroxidase and total antioxidative capacity in the jejunum and ileum.	Arginine	8-11	nuclear factor, erythroid 2 like 2	Gallus gallus	143-186
33215568-5	2020	The expression of the Bcl-2 gene was upregulated and the expression of Bax, caspase-3, and PARP gene were downregulated when L-arginine was added to the cultured cells.	Arginine	125-135	B cell leukemia/lymphoma 2	Mus musculus	22-27
33184450-5	2021	The SUMOylation sites of TAB2 mediated by TRIM60 were identified as K329 and K562; substitution of these lysines with arginines abolished the SUMOylation of TAB2.	Arginine	118-127	tripartite motif-containing 60	Mus musculus	42-48
33496113-8	2020	As compared with the normal group, the le-vels of TNF-alpha and IL-6 mRNA in the pancreatic tissues of the CUS +L-Arg group were significantly increased(P<0.01); the levels of TNF-alpha mRNA in the pancreatic tissues of the CUS group were significantly increased(P<0.05), but IL-6 mRNA level only showed a rising trend, indicating that only the CUS + L-Arg method can be used to replicate the AP damage in the disease-syndrome combination model.	Arginine	112-117	tumor necrosis factor	Rattus norvegicus	50-59
33496113-8	2020	As compared with the normal group, the le-vels of TNF-alpha and IL-6 mRNA in the pancreatic tissues of the CUS +L-Arg group were significantly increased(P<0.01); the levels of TNF-alpha mRNA in the pancreatic tissues of the CUS group were significantly increased(P<0.05), but IL-6 mRNA level only showed a rising trend, indicating that only the CUS + L-Arg method can be used to replicate the AP damage in the disease-syndrome combination model.	Arginine	112-117	interleukin 6	Rattus norvegicus	64-68
33496113-8	2020	As compared with the normal group, the le-vels of TNF-alpha and IL-6 mRNA in the pancreatic tissues of the CUS +L-Arg group were significantly increased(P<0.01); the levels of TNF-alpha mRNA in the pancreatic tissues of the CUS group were significantly increased(P<0.05), but IL-6 mRNA level only showed a rising trend, indicating that only the CUS + L-Arg method can be used to replicate the AP damage in the disease-syndrome combination model.	Arginine	112-117	tumor necrosis factor	Rattus norvegicus	176-185
33496113-8	2020	As compared with the normal group, the le-vels of TNF-alpha and IL-6 mRNA in the pancreatic tissues of the CUS +L-Arg group were significantly increased(P<0.01); the levels of TNF-alpha mRNA in the pancreatic tissues of the CUS group were significantly increased(P<0.05), but IL-6 mRNA level only showed a rising trend, indicating that only the CUS + L-Arg method can be used to replicate the AP damage in the disease-syndrome combination model.	Arginine	112-117	interleukin 6	Rattus norvegicus	276-280
33496113-8	2020	As compared with the normal group, the le-vels of TNF-alpha and IL-6 mRNA in the pancreatic tissues of the CUS +L-Arg group were significantly increased(P<0.01); the levels of TNF-alpha mRNA in the pancreatic tissues of the CUS group were significantly increased(P<0.05), but IL-6 mRNA level only showed a rising trend, indicating that only the CUS + L-Arg method can be used to replicate the AP damage in the disease-syndrome combination model.	Arginine	351-356	tumor necrosis factor	Rattus norvegicus	176-185
33260536-3	2020	The PON1-Q192R polymorphism involves a change from glutamine (Q variant) to arginine (R variant) at position 192 of the PON1 protein and affects its enzymatic activity.	Arginine	76-84	paraoxonase 1	Homo sapiens	4-8
33260536-3	2020	The PON1-Q192R polymorphism involves a change from glutamine (Q variant) to arginine (R variant) at position 192 of the PON1 protein and affects its enzymatic activity.	Arginine	76-84	paraoxonase 1	Homo sapiens	120-124
33170672-5	2020	Recent high-resolution structures of TAR-protein complexes have unveiled new details, including (i) arginine interactions with the phosphate backbone and the major-groove edge of guanine and (ii) simultaneous cation-pi contacts between the guanidinium group and flanking nucleobases.	Arginine	100-108	RNA binding motif protein 8A	Homo sapiens	37-40
33266231-2	2020	However, at an inflammatory focus, arginine residues in LL-37 can be converted to citrulline via a reaction catalyzed by peptidyl-arginine deiminases (PAD2 and PAD4), which are expressed in neutrophils and are highly active during the formation of neutrophil extracellular traps (NETs).	Arginine	35-43	cathelicidin antimicrobial peptide	Homo sapiens	56-61
33266231-5	2020	To test this hypothesis, we synthetized LL-37 in which arginine residues were substituted by homoarginine (hArg-LL-37).	Arginine	55-63	cathelicidin antimicrobial peptide	Homo sapiens	40-45
33191336-14	2020	MiR-324/SOCS3 axis could improve the H/R-induced injury of cardiomyocytes via regulating TNF/NF-kappaB signaling pathway, and this might provide a new therapy strategy for myocardial ischemia.	Arginine	2-3	tumor necrosis factor	Homo sapiens	89-92
33191336-14	2020	MiR-324/SOCS3 axis could improve the H/R-induced injury of cardiomyocytes via regulating TNF/NF-kappaB signaling pathway, and this might provide a new therapy strategy for myocardial ischemia.	Arginine	2-3	nuclear factor kappa B subunit 1	Homo sapiens	93-102
33245113-7	2020	In MCF-7 cells, it inhibited PRMT6-dependent methylation of histone H3 at arginine 2 (H3R2), which resulted in a significant repression of estrogen receptor activity.	Arginine	74-82	protein arginine methyltransferase 6	Homo sapiens	29-34
33245113-7	2020	In MCF-7 cells, it inhibited PRMT6-dependent methylation of histone H3 at arginine 2 (H3R2), which resulted in a significant repression of estrogen receptor activity.	Arginine	74-82	estrogen receptor 1	Homo sapiens	139-156
33170672-3	2020	Nearly 30 years ago, a theoretical arginine fork model was posited to account for the specificity between the HIV-1 Tat protein and TAR RNA.	Arginine	35-43	RNA binding motif protein 8A	Homo sapiens	132-135
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Arginine	248-258	superoxide dismutase 1	Homo sapiens	190-193
32918517-5	2020	Gain-of-function of PRMT1V2 clearly activated the gluconeogenic program in hepatocytes via interactions with PGC1alpha, a key transcriptional coactivator regulating gluconeogenesis, enhancing its activity via arginine methylation, while no effects of PRMT1V1 were observed.	Arginine	209-217	PPARG coactivator 1 alpha	Homo sapiens	109-118
33047125-0	2020	Impact of arginine supplementation on serum prolactin and mRNA abundance of amino acid transporter genes in mammary tissue of lactating sows.	Arginine	10-18	prolactin	Homo sapiens	44-53
33047125-1	2020	This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2 and SLC6A14 in mammary parenchymal tissue.	Arginine	74-77	prolactin	Homo sapiens	130-139
33047125-12	2020	Compared to controls, serum prolactin concentrations tended to be greater (P = 0.08) in ARG sows on d 4 of lactation, and did not differ on d 18.	Arginine	88-91	prolactin	Homo sapiens	28-37
33047125-14	2020	Dietary Arg supplementation at a rate of 0.10 g/kg BW during late pregnancy and lactation tended to increase serum prolactin concentrations with no increase in mammary transcript abundance of SLC7A1, SLC7A2 and SLC6A14 in early lactation.	Arginine	8-11	prolactin	Homo sapiens	115-124
32891072-6	2020	We further showed by pharmacological treatments that dynamic microtubule (MT) organization and Ca2+ signaling are both critical for FER-mediated ARG.	Arginine	145-148	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	132-135
32956589-7	2020	Radical capture represents the key Csp-Csp3 bond forming step in the copper catalyzed C-H functionalization of benzylic substrates R-H with alkynes H-C CR" (R" = (hetero)aryl, silyl) that provide Csp-Csp3 coupled products R-C CR via radical relay with tBuOOtBu as oxidant.	Arginine	0-1	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	35-38
32956589-7	2020	Radical capture represents the key Csp-Csp3 bond forming step in the copper catalyzed C-H functionalization of benzylic substrates R-H with alkynes H-C CR" (R" = (hetero)aryl, silyl) that provide Csp-Csp3 coupled products R-C CR via radical relay with tBuOOtBu as oxidant.	Arginine	0-1	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	39-42
33180886-5	2020	The results obtained by transfection assays of recombinant wild type and mutated forms of Danio rerio Fabp2 in Caco-2 cell cultures, showed that lysine 17, arginine 29 and lysine 30 residues, which are located in the helix-turn-helix region, would constitute a functional non-classical three-dimensional NLS.	Arginine	156-164	fatty acid binding protein 2, intestinal	Danio rerio	102-107
33106423-8	2020	Binding to Scap requires an arginine residue in exon 18 of SREBP2.	Arginine	28-36	sterol regulatory element binding transcription factor 2	Homo sapiens	59-65
33160404-6	2020	We carried out a multivariate Cox regression analysis and developed six ARG-related prognostic signature for the survival prediction of patients with squamous cell cervical cancer (Risk score = - 0.63*ATG3-0.42*BCL2 + 0.85*CD46-0.38*IFNG+ 0.23*NAMPT+ 0.82*TM9SF1).	Arginine	72-75	BCL2 apoptosis regulator	Homo sapiens	211-215
33160404-6	2020	We carried out a multivariate Cox regression analysis and developed six ARG-related prognostic signature for the survival prediction of patients with squamous cell cervical cancer (Risk score = - 0.63*ATG3-0.42*BCL2 + 0.85*CD46-0.38*IFNG+ 0.23*NAMPT+ 0.82*TM9SF1).	Arginine	72-75	interferon gamma	Homo sapiens	233-237
33343341-10	2020	Additionally, wortmannin and Akt inhibitor VIII blocked the protective effect of gastrin on viability of HK-2 cells subjected to H/R treatment.	Arginine	131-132	AKT serine/threonine kinase 1	Homo sapiens	29-32
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	nitric oxide synthase 2, inducible	Mus musculus	176-180
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	nitric oxide synthase 2, inducible	Mus musculus	176-180
32707041-6	2020	PRMT5 knockdown increased the levels of amino acids and carbohydrates, particularly related to the arginine metabolism such as glutamate, glutamine (Gln), proline, creatine, creatinine and phosphocreatine (PCr).	Arginine	99-107	protein arginine methyltransferase 5	Homo sapiens	0-5
32707041-7	2020	CONCLUSIONS: These findings revealed a key role for PRMT5 as a regulator of CRC cell metabolism to mediate arginine methylation in CRC cells.	Arginine	107-115	protein arginine methyltransferase 5	Homo sapiens	52-57
32743799-5	2020	Liver of Gldc-deficient mice accumulated glycine and numerous glycine derivatives, including multiple acylglycines, indicating increased flux through reactions mediated by enzymes including glycine-N-acyltransferase and arginine:glycine amidinotransferase.	Arginine	220-228	glycine decarboxylase	Mus musculus	9-13
33111589-9	2021	The L-arginine antagonist, NG-Nitro-L-arginine Methyl Ester, reduced caspase-3 activity in A23187-stimulated PLPs generated from ASA-incubated Meg-01 cells.	Arginine	4-14	caspase 3	Homo sapiens	69-78
33097830-6	2020	Mechanistically, we find that L-arginine stimulates Wnt2b secretion by CD90+ stromal cells through the mammalian target of rapamycin complex 1 (mTORC1) and that blocking Wnt2b production prevents L-arginine-induced ISC expansion.	Arginine	196-206	Wnt family member 2B	Homo sapiens	170-175
32800549-0	2020	The yeast alpha-arrestin Art3 is a key regulator for arginine-induced endocytosis of the high-affinity proline transporter Put4.	Arginine	53-61	Aly2p	Saccharomyces cerevisiae S288C	25-29
33097830-0	2020	Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b.	Arginine	10-20	thymus cell antigen 1, theta	Mus musculus	69-73
33097830-5	2020	Furthermore, CD90+ intestinal stromal cells augment stem-cell function in response to L-arginine in co-culture experiments.	Arginine	86-96	thymus cell antigen 1, theta	Mus musculus	13-17
33097830-6	2020	Mechanistically, we find that L-arginine stimulates Wnt2b secretion by CD90+ stromal cells through the mammalian target of rapamycin complex 1 (mTORC1) and that blocking Wnt2b production prevents L-arginine-induced ISC expansion.	Arginine	30-40	Wnt family member 2B	Homo sapiens	52-57
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	membrane metalloendopeptidase	Homo sapiens	41-51
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	membrane metalloendopeptidase	Homo sapiens	53-56
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	membrane metalloendopeptidase	Homo sapiens	41-51
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	membrane metalloendopeptidase	Homo sapiens	53-56
32959643-2	2020	Herein, we report the rational design of the bioinspired 4-(2-guanidino)-1,8-naphthalimide fluorescent probes NAP-DCP-1 and NAP-DCP-3 from arginine-specific protein modifications.	Arginine	139-147	decapping mRNA 1B	Homo sapiens	114-119
32800549-9	2020	More importantly, we discovered that deletion of ART3 remarkably canceled the inhibitory effects of arginine on proline utilization.	Arginine	100-108	Aly2p	Saccharomyces cerevisiae S288C	49-53
33053340-4	2020	A patient-derived R140Q FMRP point mutation mislocalizes PKA-SPARK activity, whereas deletion of the RNA-binding arginine-glycine-glycine (RGG) box (hFMRP-DeltaRGG) produces fibrillar PKA-SPARK assemblies colocalizing with ribonucleoprotein (RNP) and aggregation (thioflavin T) markers, demonstrating fibrillar partitioning of cytosolic protein aggregates.	Arginine	113-121	fragile X messenger ribonucleoprotein 1	Homo sapiens	149-154
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	332-361
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	363-367
33057142-4	2020	In the case of Type-2 Diabetes, this study demonstrated that possible glycation of the OC protein can occur through covalent crosslinking between Arginine and N-terminus regions, causing disruption of alpha-helices leading to a lower protein affinity to the HAp surface.	Arginine	146-154	bone gamma-carboxyglutamate protein	Homo sapiens	87-89
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	AKT serine/threonine kinase 1	Homo sapiens	215-218
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	AKT serine/threonine kinase 1	Homo sapiens	219-222
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	mitogen-activated protein kinase 1	Homo sapiens	258-299
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	mitogen-activated protein kinase 3	Homo sapiens	301-307
32452600-7	2020	While complexes [Ru(R-PYA-pincer)(PPh 3 )(MeCN) 2 ](PF 6 ) 2  were only isolated for R = H, Me, an  in situ  protocol was developed to generate these complexes  in situ  for R = OMe, Cl, CF 3  by using a 1:2 ratio of the complexes and PPh 3 .	Arginine	17-18	caveolin 1	Homo sapiens	34-39
32452600-7	2020	While complexes [Ru(R-PYA-pincer)(PPh 3 )(MeCN) 2 ](PF 6 ) 2  were only isolated for R = H, Me, an  in situ  protocol was developed to generate these complexes  in situ  for R = OMe, Cl, CF 3  by using a 1:2 ratio of the complexes and PPh 3 .	Arginine	17-18	caveolin 1	Homo sapiens	235-240
32658257-3	2020	We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.	Arginine	46-48	Fc gamma receptor and transporter	Homo sapiens	152-172
33051367-4	2020	The sensor promptly activates a mitogen-activated protein kinase 2 (MAPK2)-mediated arginine deprivation response (ADR) pathway, resulting in upregulating the abundance and activity of the Leishmania arginine transporter (AAP3).	Arginine	84-92	mitogen-activated protein kinase 1	Homo sapiens	32-66
33051367-4	2020	The sensor promptly activates a mitogen-activated protein kinase 2 (MAPK2)-mediated arginine deprivation response (ADR) pathway, resulting in upregulating the abundance and activity of the Leishmania arginine transporter (AAP3).	Arginine	84-92	mitogen-activated protein kinase 1	Homo sapiens	68-73
32960212-8	2020	PRMT5-induced symmetrical di-methylation of arginine residues of hnRNP A1 enabled the ITAF to stimulate the HIV-1 and HTLV-1 IRESs while reducing the stimulatory ability of the ITAF over the MMTV IRES.	Arginine	44-52	protein arginine methyltransferase 5	Homo sapiens	0-5
32207970-0	2020	A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5.	Arginine	9-17	WD repeat domain 5	Homo sapiens	93-97
32207970-0	2020	A binary arginine methylation switch on histone H3 Arginine 2 regulates its interaction with WDR5.	Arginine	51-59	WD repeat domain 5	Homo sapiens	93-97
32207970-7	2020	Despite modest structural differences at the binding interface, our study supports an interaction model regulated by a binary arginine methylation switch: H3R2me2a prevents interaction with WDR5, whereas H3R2me0/me1/me2s are equally permissive.	Arginine	126-134	WD repeat domain 5	Homo sapiens	190-194
32945480-7	2020	The results showed that, miR-30a-5p mimic reduced the production of ROS in HK-2 cells treated with H/R, but increased the activity of SOD, CAT and GPx.	Arginine	27-28	superoxide dismutase 1	Homo sapiens	134-137
32568451-4	2020	Endothelial NO, synthesized from L-arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis and tumor cell proliferation.	Arginine	33-43	nitric oxide synthase 3	Homo sapiens	72-76
32830871-10	2020	Collectively, arginine-rich DPR-mediated impairment of EXOSC10 and the RNA exosome complex compromises repeat RNA metabolism and may thus exacerbate C9orf72-FTLD/ALS pathologies in a vicious cycle.	Arginine	14-22	exosome component 10	Homo sapiens	55-62
32725787-1	2020	HLA-A*31:72 has one nucleotide change from HLA-A*31:01:02:01 where Histidine (188) is changed to Arginine.	Arginine	97-105	major histocompatibility complex, class I, A	Homo sapiens	0-5
32725787-1	2020	HLA-A*31:72 has one nucleotide change from HLA-A*31:01:02:01 where Histidine (188) is changed to Arginine.	Arginine	97-105	major histocompatibility complex, class I, A	Homo sapiens	43-48
32945431-8	2020	Furthermore, the silencing of PRMT6 significantly reduced the enrichment of Histone H3 asymmetric demethylation at arginine 2 in the promoter region of the p18 gene, thereby activating the expression of the gene.	Arginine	115-123	protein arginine methyltransferase 6	Homo sapiens	30-35
32945431-8	2020	Furthermore, the silencing of PRMT6 significantly reduced the enrichment of Histone H3 asymmetric demethylation at arginine 2 in the promoter region of the p18 gene, thereby activating the expression of the gene.	Arginine	115-123	H3 histone pseudogene 12	Homo sapiens	156-159
32945480-7	2020	The results showed that, miR-30a-5p mimic reduced the production of ROS in HK-2 cells treated with H/R, but increased the activity of SOD, CAT and GPx.	Arginine	27-28	catalase	Homo sapiens	139-142
33214833-1	2020	Protein arginine methyltransferase 5 (PRMT5) is an enzyme that can symmetrically dimethylate arginine residues in histones and nonhistone proteins by using S-adenosyl methionine (SAM) as the methyl donating cofactor.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
32997990-2	2020	From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of actin (R256me1).	Arginine	71-79	actin	Saccharomyces cerevisiae S288C	5-10
32997990-2	2020	From actin-containing chromatin remodeling complexes, we discovered an arginine mono-methylation mark on an evolutionarily conserved R256 residue of actin (R256me1).	Arginine	71-79	actin	Saccharomyces cerevisiae S288C	149-154
33209735-1	2020	The RARS2 gene encodes mitochondrial arginine-tRNA synthetase.	Arginine	37-45	arginyl-tRNA synthetase 2, mitochondrial	Homo sapiens	4-9
32995772-3	2020	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	vascular endothelial growth factor A	Homo sapiens	116-122
32985589-5	2020	Our findings reveal for the first time that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical for YBX1-mediated NF-kappaB activation and its downstream target gene expression.	Arginine	83-91	protein arginine methyltransferase 5	Homo sapiens	44-49
32985589-5	2020	Our findings reveal for the first time that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical for YBX1-mediated NF-kappaB activation and its downstream target gene expression.	Arginine	83-91	Y-box binding protein 1	Homo sapiens	75-79
32985589-5	2020	Our findings reveal for the first time that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical for YBX1-mediated NF-kappaB activation and its downstream target gene expression.	Arginine	83-91	Y-box binding protein 1	Homo sapiens	97-101
32985589-5	2020	Our findings reveal for the first time that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical for YBX1-mediated NF-kappaB activation and its downstream target gene expression.	Arginine	83-91	Y-box binding protein 1	Homo sapiens	97-101
32985589-5	2020	Our findings reveal for the first time that PRMT5 catalyzes methylation of YBX1 at arginine 205 (YBX1-R205me2), an event that is critical for YBX1-mediated NF-kappaB activation and its downstream target gene expression.	Arginine	83-91	nuclear factor kappa B subunit 1	Homo sapiens	156-165
32995772-3	2020	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	vascular endothelial growth factor A	Homo sapiens	78-114
32623092-5	2020	DNA sequence analysis of the BR receptor-1 (BRI-1) gene detected a single-nucleotide A > G substitution at the position 2612 in the kinase domain which resulted in the change of His (CAC) to Arg (CGC) at residue 857 in subdomain IV of the kinase domain of the respective polypeptide.	Arginine	191-194	BRI1	Hordeum vulgare	44-49
32780724-7	2020	High levels of arginase-1 in Tim-4+ TAMs contributed to potent mitophagy activities via weakened mTORC1 activation due to low arginine resultant from arginase-1-mediated metabolism.	Arginine	126-134	T cell immunoglobulin and mucin domain containing 4	Mus musculus	29-34
32905770-6	2020	Furthermore, ectopic expression of AtAN3 from Arabidopsis thaliana ameliorates the defective arginine metabolism and promotes gametophore formation in Ppan3 mutants.	Arginine	93-101	SSXT family protein	Arabidopsis thaliana	35-40
32449816-1	2020	It was anticipated that the potassium reagent RK (R = CH(SiMe3)2 or N(SiMe3)2) reacts with the low-valent Al(I) complex (DIPPBDI)Al (DIPPBDI = HC[C(Me)N(DIPP)]2, DIPP = 2,6-iPr-phenyl) to the anionic Al complex [(DIPPBDI)AlR]-K+.	Arginine	46-47	nudix hydrolase 4	Homo sapiens	162-170
32474021-16	2020	MD-2 deficiency also blocked H/R-mediated activation of the TLR4/TRAF6/NF-kappaB pathway, and pyrrolidinedithiocarbamate (PDTC) pretreatment strengthened the anti-inflammatory and antioxidant damage effects of MD-2 silencing.	Arginine	31-32	toll-like receptor 4	Mus musculus	60-64
32474021-16	2020	MD-2 deficiency also blocked H/R-mediated activation of the TLR4/TRAF6/NF-kappaB pathway, and pyrrolidinedithiocarbamate (PDTC) pretreatment strengthened the anti-inflammatory and antioxidant damage effects of MD-2 silencing.	Arginine	31-32	TNF receptor-associated factor 6	Mus musculus	65-70
32474021-16	2020	MD-2 deficiency also blocked H/R-mediated activation of the TLR4/TRAF6/NF-kappaB pathway, and pyrrolidinedithiocarbamate (PDTC) pretreatment strengthened the anti-inflammatory and antioxidant damage effects of MD-2 silencing.	Arginine	31-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
32886592-4	2020	Depending on l-arginine availability, nitric oxide synthase 2 (NOS2) of the host cell produces nitric oxide (NO) controlling the parasite growth.	Arginine	13-23	nitric oxide synthase 2, inducible	Mus musculus	38-61
32886592-4	2020	Depending on l-arginine availability, nitric oxide synthase 2 (NOS2) of the host cell produces nitric oxide (NO) controlling the parasite growth.	Arginine	13-23	nitric oxide synthase 2, inducible	Mus musculus	63-67
32848060-2	2020	Unlike other coactivators, PGC-1alpha contains protein domains involved in RNA regulation such as serine/arginine (SR) and RNA recognition motifs (RRMs).	Arginine	105-113	PPARG coactivator 1 alpha	Homo sapiens	27-37
32899690-0	2020	Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA.	Arginine	8-16	fms related receptor tyrosine kinase 1	Homo sapiens	63-70
32899690-0	2020	Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA.	Arginine	8-16	fms related receptor tyrosine kinase 1	Homo sapiens	72-77
32899690-8	2020	In this review, we introduce and discuss the mechanism of alternative polyadenylation of VEGFR-1 mediated by protein arginine methylation.	Arginine	117-125	fms related receptor tyrosine kinase 1	Homo sapiens	89-96
32387127-7	2020	While the former showed high diagnostic accuracy and superiority over the indirect water deprivation test in a recent validation study, the diagnostic accuracy for arginine-stimulated copeptin was slightly lower, but superior in test tolerance.	Arginine	164-172	arginine vasopressin	Homo sapiens	184-192
32518064-5	2020	In HNF1A mutation carriers, we observed: 1) hypoinsulinemia, 2) insulinotropic effects of both GIP and GLP-1, 3) additive to supra-additive effects on insulin secretion when combining SU+GIP and SU+GLP-1, respectively, and 4) increased fasting and arginine-induced glucagon levels compared with control subjects without diabetes.	Arginine	248-256	HNF1 homeobox A	Homo sapiens	3-8
32557770-9	2020	We then observed that arginine induced the endocytosis of the proline transporters Put4 and Gap1, whereas ammonium induced the endocytosis of only Gap1.	Arginine	22-30	amino acid permease GAP1	Saccharomyces cerevisiae S288C	92-96
32867030-0	2020	L-Arginine Modulates Neonatal Leukocyte Recruitment in a Gestational Age-Dependent Manner.	Arginine	0-10	renin binding protein	Homo sapiens	69-72
32817790-6	2020	These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis (sterol regulatory element-binding protein-1, acetyl-CoA carboxylase alpha, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid beta-oxidation (carnitine palmitoyltransferase 1alpha and peroxisome proliferator-activated receptor alpha).	Arginine	17-25	acetyl-CoA carboxylase 1	Oreochromis niloticus	152-180
32854180-8	2020	Of these peptides, Isoleucine-Lysine- Glutamic Acid-Valine-Threonine-Glutamic Acid-Arginine (IKEVTER) demonstrated the highest ACE inhibitory activity.	Arginine	83-91	angiotensin I converting enzyme	Homo sapiens	127-130
32814773-0	2020	Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming.	Arginine	27-35	mitogen-activated protein kinase 1	Homo sapiens	63-66
32814773-6	2020	When integrated with metabolomic profiling, this multi-omic analysis reveals that cellular response to arginine starvation is mediated by adaptive ERK signaling and activation of the Myc-Max transcriptional network.	Arginine	103-111	mitogen-activated protein kinase 1	Homo sapiens	147-150
32884268-9	2020	The phosphor imaging autoradiography (PI-ARG) results corroborated the PET and gamma counter measurements, showing higher accumulation of 89Zr-Mal-HSA in the aortas of Apoe-/- mice than in WT mice (9.4+-1.4 vs 0.8+-0.3%; P<0.001).	Arginine	41-44	apolipoprotein E	Mus musculus	168-172
32824565-3	2020	B2R is activated by kinins, while B1R is activated by kinins that lack the C-terminal arginine residue.	Arginine	86-94	bradykinin receptor B1	Homo sapiens	34-37
32783662-4	2020	In addition, L-arginine injections significantly (p < .0001) increased the expression of TNF-alpha mRNA and protein, and decreased phospho-AMPK and IL-10 mRNA and protein that was significantly (p < .0001) protected by vitamin E.	Arginine	13-23	tumor necrosis factor	Rattus norvegicus	89-98
32783662-4	2020	In addition, L-arginine injections significantly (p < .0001) increased the expression of TNF-alpha mRNA and protein, and decreased phospho-AMPK and IL-10 mRNA and protein that was significantly (p < .0001) protected by vitamin E.	Arginine	13-23	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	139-143
32783662-6	2020	CONCLUSIONS: L-arginine-induced acute pancreatitis modulates TNF-alpha-AMPK axis, IL-10 and other AP biomarkers, which is protected by vitamin E; thus, may offer therapeutic potential in humans.	Arginine	13-23	tumor necrosis factor	Homo sapiens	61-70
32424988-7	2020	MPO was increased in HFpEF compared with controls, 101 (81;132) vs. 86 (74;101 ng/mL, P = 0.015), as was uric acid 369 (314;439) vs. 289 (252;328 mumol/L, P < 0.001), calprotectin, asymmetric dimethyl arginine (ADMA), and symmetric dimethyl arginine (SDMA), while arginine was decreased.	Arginine	201-209	myeloperoxidase	Homo sapiens	0-3
32450093-3	2020	Here, a six-arginine-tailed anti-epidermal growth factor receptor (EGFR) affibody was employed to easily synthesize the highly reactive oxygen species (hROS)- and trypsin-responsive 11-mercaptoundecanoic acid-modified gold nanoclusters (MUA-Au NCs) for tumor-targeted drug delivery.	Arginine	12-20	epidermal growth factor receptor	Homo sapiens	33-65
32450093-3	2020	Here, a six-arginine-tailed anti-epidermal growth factor receptor (EGFR) affibody was employed to easily synthesize the highly reactive oxygen species (hROS)- and trypsin-responsive 11-mercaptoundecanoic acid-modified gold nanoclusters (MUA-Au NCs) for tumor-targeted drug delivery.	Arginine	12-20	epidermal growth factor receptor	Homo sapiens	67-71
32944135-1	2020	Protein arginine methyltransferase 5 (PRMT5) belongs to a family of enzymes that regulate the posttranslational modification of histones and other proteins via methylation of arginine.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
32848891-9	2020	Conclusion: The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients.	Arginine	53-61	nitric oxide synthase 3	Homo sapiens	112-135
32848891-9	2020	Conclusion: The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients.	Arginine	53-61	nitric oxide synthase 3	Homo sapiens	137-141
32898326-8	2020	RESULTS: In the "long survivor" group, deleterious/loss-of-function variants were enriched in genes including CLCN6 (a voltage-dependent chloride channel for which rare deleterious variants have been associated with lower blood pressure) and OGHDL (important in arginine metabolism, which is a therapeutic target in SCA).	Arginine	262-270	chloride voltage-gated channel 6	Homo sapiens	110-115
32862756-8	2020	Arg-1 expression was significantly increased in a group that received an heme oxygenase 1 (HO-1) agonist and significantly decreased in a group that received an HO-1 inhibitor but there were no differences in the expression of iNOS or Nrf2.	Arginine	0-3	heme oxygenase 1	Mus musculus	73-89
32404595-12	2020	CONCLUSIONS: HBSP inhibits excessive autophagy and apoptosis induced by H/R by activating the PI3K/Akt pathway.	Arginine	74-75	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
32725957-6	2020	Pre-treatment with L-arginine enhances the ISCs pool and protects the gut in response to injury provoked by murine tumor necrosis factor alpha (TNF-alpha) and 5-Fluorouracil (5-FU).	Arginine	19-29	tumor necrosis factor	Mus musculus	115-142
32725957-6	2020	Pre-treatment with L-arginine enhances the ISCs pool and protects the gut in response to injury provoked by murine tumor necrosis factor alpha (TNF-alpha) and 5-Fluorouracil (5-FU).	Arginine	19-29	tumor necrosis factor	Mus musculus	144-153
32862756-8	2020	Arg-1 expression was significantly increased in a group that received an heme oxygenase 1 (HO-1) agonist and significantly decreased in a group that received an HO-1 inhibitor but there were no differences in the expression of iNOS or Nrf2.	Arginine	0-3	heme oxygenase 1	Mus musculus	91-95
32862756-8	2020	Arg-1 expression was significantly increased in a group that received an heme oxygenase 1 (HO-1) agonist and significantly decreased in a group that received an HO-1 inhibitor but there were no differences in the expression of iNOS or Nrf2.	Arginine	0-3	heme oxygenase 1	Mus musculus	161-165
32850814-6	2020	Subsequent immunoprecipitation analysis, including different MAPK1 mutants, revealed that VB1 directly interacted with the residues, glutamic acid 58 (E58) and arginine 65 (R65) of MAPK1, leading to the partial reversal of UVA-induced senescence in HEK293T cells.	Arginine	160-168	mitogen-activated protein kinase 1	Homo sapiens	181-186
32412630-7	2020	Arg supplementation decreased (P < 0.05) the protein abundance of apoptosis antigen 1 (FAS) (52.0% and 43.9%) but increased (P < 0.05) those of nuclear respiratory factor 1 (31.3% and 22.9%) and inducible NO synthase (35.2% and 41.8%) relative to the CON and CON + NAME groups, respectively.	Arginine	0-3	nitric oxide synthase 2	Homo sapiens	195-216
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	35-43	amino acid permease GAP1	Saccharomyces cerevisiae S288C	55-59
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	amino acid permease GAP1	Saccharomyces cerevisiae S288C	55-59
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	amino acid permease GAP1	Saccharomyces cerevisiae S288C	55-59
32633941-6	2020	First, the fibronectin overexpressed in the extracellular matrix (ECM) of TNBC was used as a biomarker for targeting theranostics using the Cys-Arg-Glu-Lys-Ala (CREKA) peptide.	Arginine	144-147	fibronectin 1	Homo sapiens	11-22
32727419-8	2020	CONCLUSIONS: This pilot study suggests that both the Arg/Arg and Arg/Pro genotypes of p53 codon 72 polymorphism may have value as independent prognostic or predictive parameters for bevacizumab treatment response and failure.	Arginine	53-56	tumor protein p53	Homo sapiens	86-89
32722521-4	2020	By producing L-ornithine while competing with nitric oxide synthase (NOS) for the same substrate (L-arginine), arginase can influence the endogenous levels of polyamines, proline, and NO .	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	46-67
32711437-12	2020	Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively).	Arginine	57-60	tumor protein p53	Homo sapiens	78-82
32532885-3	2020	Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells.	Arginine	131-139	relaxin family peptide receptor 3	Rattus norvegicus	88-93
32676531-1	2020	The article shows dataset of the proteolysis of a natural variant of apolipoprotein A-I (apoA-I) with a substitution of a leucine by and arginine in position 60 (L60R), in comparison with the protein with the native sequence (Wt).	Arginine	137-145	apolipoprotein A1	Homo sapiens	69-87
32676531-1	2020	The article shows dataset of the proteolysis of a natural variant of apolipoprotein A-I (apoA-I) with a substitution of a leucine by and arginine in position 60 (L60R), in comparison with the protein with the native sequence (Wt).	Arginine	137-145	apolipoprotein A1	Homo sapiens	89-95
32709847-2	2020	E2F1 is the major target through which pRb exerts its effects and arginine methylation by PRMT5 plays a key role in dictating E2F1 activity.	Arginine	66-74	protein arginine methyltransferase 5	Homo sapiens	90-95
33005891-3	2020	Most of the mutations are substitutions to a non-charged residue, from the positively charged arginine (R) in transmembrane segment 4 (S4) of a voltage sensor in either CaV1.1 or NaV1.4.	Arginine	94-102	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	169-175
32754051-5	2020	L-arginine treatment during 7 days of rat HS prevented HS-induced NO content decrease and slow MyHC mRNA transcription decrease and attenuated fast MyHC IIb mRNA transcription increase; it also prevented NFATc1 nuclear content decrease, calsarcin-2 expression increase, and GSK-3beta Ser 9 phosphorylation decrease.	Arginine	0-10	myosin heavy chain 13	Rattus norvegicus	95-99
32754051-5	2020	L-arginine treatment during 7 days of rat HS prevented HS-induced NO content decrease and slow MyHC mRNA transcription decrease and attenuated fast MyHC IIb mRNA transcription increase; it also prevented NFATc1 nuclear content decrease, calsarcin-2 expression increase, and GSK-3beta Ser 9 phosphorylation decrease.	Arginine	0-10	myosin heavy chain 13	Rattus norvegicus	148-152
32754051-6	2020	Moreover, L-arginine administration prevented the HS-induced myh7b and PGC1alpha mRNAs content decreases and slow-type genes repressor SOX6 mRNA transcription increase.	Arginine	10-20	PPARG coactivator 1 alpha	Rattus norvegicus	71-80
32501667-7	2020	Arg-rich poly(epsilon-caprolactone) (PCL)-b-PArg, a macromolecular NO donor, was accurately synthesized to avoid premature L-Arg leakage during in vivo transportation.	Arginine	0-3	poly(ADP-ribose) glycohydrolase	Homo sapiens	44-48
32501667-7	2020	Arg-rich poly(epsilon-caprolactone) (PCL)-b-PArg, a macromolecular NO donor, was accurately synthesized to avoid premature L-Arg leakage during in vivo transportation.	Arginine	123-128	poly(ADP-ribose) glycohydrolase	Homo sapiens	44-48
32711445-9	2020	RESULTS: Administration of L-arginine to cisplatin-treated rats induced significant decrease in the average ABR threshold shifts at all frequencies, tissue TGF-beta1, TNF-alpha and IL-15 associated with significant increase in tissue antioxidant enzymes, total nitrate/nitrite and Nrf2/HO-1 content compared to cisplatin group.	Arginine	27-37	transforming growth factor, beta 1	Rattus norvegicus	156-165
32711445-9	2020	RESULTS: Administration of L-arginine to cisplatin-treated rats induced significant decrease in the average ABR threshold shifts at all frequencies, tissue TGF-beta1, TNF-alpha and IL-15 associated with significant increase in tissue antioxidant enzymes, total nitrate/nitrite and Nrf2/HO-1 content compared to cisplatin group.	Arginine	27-37	tumor necrosis factor	Rattus norvegicus	167-176
32711445-9	2020	RESULTS: Administration of L-arginine to cisplatin-treated rats induced significant decrease in the average ABR threshold shifts at all frequencies, tissue TGF-beta1, TNF-alpha and IL-15 associated with significant increase in tissue antioxidant enzymes, total nitrate/nitrite and Nrf2/HO-1 content compared to cisplatin group.	Arginine	27-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	281-285
32236441-1	2020	CONTEXT: Arginine stimulates pituitary hormones, like growth hormone and vasopressin, but its effect on the hypothalamic-pituitary-adrenal (HPA) axis is unknown.	Arginine	9-17	growth hormone 1	Homo sapiens	54-68
32353563-6	2020	Curiously, the deletion of arginine(s) of MTRR could not affect the electron relay, if only the FMN_Red domain was intact, but by degrees reduced the ability to promote MTR catalysis in methionine formation.	Arginine	27-35	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	42-46
32353563-8	2020	The tandem arginines at the end of MTRR N-terminus conferring high affinity to MTR were indispensable for stimulating methyltransferase activity perhaps via triggering allosteric effect that could be attenuated by removal of the arginine(s).	Arginine	11-20	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	35-39
32353563-8	2020	The tandem arginines at the end of MTRR N-terminus conferring high affinity to MTR were indispensable for stimulating methyltransferase activity perhaps via triggering allosteric effect that could be attenuated by removal of the arginine(s).	Arginine	11-19	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	35-39
32353563-9	2020	It was concluded that MTRR could also propel MTR enzymatic reaction relying on the tandem arginines at N-terminus more than just only implicated in electron transfer in MTR reactivation cycle.	Arginine	90-99	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	22-26
32513315-5	2020	We discuss the association between genetic variation in RYR2, particularly mutations causing replacement of arginine at position 169 of RYR2 and structural cardiac abnormalities.	Arginine	108-116	ryanodine receptor 2	Homo sapiens	56-60
32513315-5	2020	We discuss the association between genetic variation in RYR2, particularly mutations causing replacement of arginine at position 169 of RYR2 and structural cardiac abnormalities.	Arginine	108-116	ryanodine receptor 2	Homo sapiens	136-140
32426941-10	2020	Importantly, additional supplementation of L-arginine significantly increased the number of cured mice that were treated with CP and anti-PD-1 antibody.	Arginine	43-53	programmed cell death 1	Mus musculus	138-142
32017362-4	2020	RESULTS: The acute insulin response to glucose potentiation of arginine-induced insulin release was less in non-obese T2D than in controls and associated with impaired beta-cell sensitivity to glucose (PG50 ).	Arginine	63-71	insulin	Homo sapiens	19-26
32017362-4	2020	RESULTS: The acute insulin response to glucose potentiation of arginine-induced insulin release was less in non-obese T2D than in controls and associated with impaired beta-cell sensitivity to glucose (PG50 ).	Arginine	63-71	insulin	Homo sapiens	80-87
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Arginine	203-211	HNF1 homeobox A	Homo sapiens	80-85
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Arginine	203-211	albumin	Homo sapiens	121-128
32474770-7	2020	Western blotting showed that the levels both activating and inhibitory C/EBPbeta isoforms were significantly increased in cells grown in arginine medium.	Arginine	137-145	CCAAT enhancer binding protein alpha	Homo sapiens	71-80
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Arginine	19-27	albumin	Homo sapiens	43-50
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Arginine	19-27	CCAAT enhancer binding protein alpha	Homo sapiens	177-186
32236441-1	2020	CONTEXT: Arginine stimulates pituitary hormones, like growth hormone and vasopressin, but its effect on the hypothalamic-pituitary-adrenal (HPA) axis is unknown.	Arginine	9-17	arginine vasopressin	Homo sapiens	73-84
32236441-2	2020	Arginine may also stimulate the HPA axis, possibly through a mechanism involving vasopressin.	Arginine	0-8	arginine vasopressin	Homo sapiens	81-92
32236441-3	2020	OBJECTIVE: To investigate the effect of arginine on adrenocorticotropic hormone (ACTH) and cortisol in subjects with and without vasopressin deficiency.	Arginine	40-48	proopiomelanocortin	Homo sapiens	81-85
32236441-6	2020	INTERVENTION: Arginine infusion with measurement of ACTH, cortisol and copeptin at baseline and 30/45/60/90/120 minutes.	Arginine	14-22	proopiomelanocortin	Homo sapiens	52-56
32236441-6	2020	INTERVENTION: Arginine infusion with measurement of ACTH, cortisol and copeptin at baseline and 30/45/60/90/120 minutes.	Arginine	14-22	arginine vasopressin	Homo sapiens	71-79
32236441-7	2020	RESULTS: We found different response patterns to arginine: In patients with diabetes insipidus (and low stimulated copeptin levels) median [IQR] ACTH and cortisol increased from 22.9 [16.8, 38.7] to 36.6 [26.2, 52.1] ng/l and from 385 [266, 463] to 467 [349, 533] nmol/l, respectively.	Arginine	49-57	arginine vasopressin	Homo sapiens	115-123
32236441-7	2020	RESULTS: We found different response patterns to arginine: In patients with diabetes insipidus (and low stimulated copeptin levels) median [IQR] ACTH and cortisol increased from 22.9 [16.8, 38.7] to 36.6 [26.2, 52.1] ng/l and from 385 [266, 463] to 467 [349, 533] nmol/l, respectively.	Arginine	49-57	proopiomelanocortin	Homo sapiens	145-149
32236441-9	2020	CONCLUSION: Diabetes insipidus is associated with increased responsiveness of ACTH/cortisol to arginine.	Arginine	95-103	proopiomelanocortin	Homo sapiens	78-82
32409599-4	2020	Here we show that in the presence of arginine, the arginine sensor ArgR, identified through this screen, directly activates expression of the genes encoding the T3SS.	Arginine	37-45	arginine repressor	Escherichia coli	67-71
32561357-2	2020	OBJECTIVE: This meta-analysis was performed to assess the effects of l-arginine supplementation on indices of glycemic control, including fasting blood glucose (FBG), hemoglobin A1c (HbA1c), serum insulin and homeostatic model assessment of insulin resistance (HOMA-IR) levels in randomized controlled trials (RCTs).	Arginine	69-79	insulin	Homo sapiens	197-204
32561357-2	2020	OBJECTIVE: This meta-analysis was performed to assess the effects of l-arginine supplementation on indices of glycemic control, including fasting blood glucose (FBG), hemoglobin A1c (HbA1c), serum insulin and homeostatic model assessment of insulin resistance (HOMA-IR) levels in randomized controlled trials (RCTs).	Arginine	69-79	insulin	Homo sapiens	241-248
32561357-9	2020	RESULTS: Pooled random-effect analysis revealed that l-arginine supplementation could significantly decrease FBG level (weighted mean difference [WMD]: 3.35 mg/dL; 95% confidence interval [CI] = [-6.55, -0.16]; P = 0.04) and serum insulin level (WMD: -2.19 muIU/mL; 95% CI = [-3.70, -0.67]; P = 0.005).	Arginine	53-63	insulin	Homo sapiens	231-238
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Arginine	144-147	lactalbumin alpha	Homo sapiens	67-84
32088030-4	2020	Arginine activates the mechanistic target of rapamycin (MTOR) nutrient sensing cell signaling pathway to stimulate proliferation, migration, differentiation and translation of mRNAs essential for growth and development of the conceptus.	Arginine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	23-54
32088030-4	2020	Arginine activates the mechanistic target of rapamycin (MTOR) nutrient sensing cell signaling pathway to stimulate proliferation, migration, differentiation and translation of mRNAs essential for growth and development of the conceptus.	Arginine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	56-60
32630528-2	2020	The histidine to arginine substitution at position 6 of the Abeta sequence (H6R, English mutation) leads to an early onset of AD.	Arginine	17-25	amyloid beta precursor protein	Homo sapiens	60-65
32312763-1	2020	l-Arginine metabolism through arginase 1 (Arg-1) and inducible nitric oxide synthase (NOS2) constitutes a fundamental axis for the resolution or progression of leishmaniasis.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	86-90
32312763-3	2020	In this work, we analyzed in an in vivo model the capacity of two L. mexicana isolates, one obtained from a patient with LCL and the other from a patient with DCL, to regulate the metabolism of l-arginine through Arg-1 and NOS2.	Arginine	194-204	nitric oxide synthase 2	Homo sapiens	223-227
32350111-7	2020	We demonstrate that unique BMP15 finger residues at this site (Arg-301, Gly-304, His-307, and Met-369) enable potent activation of the SMAD2/3 pathway.	Arginine	63-66	bone morphogenetic protein 15	Homo sapiens	27-32
32593534-7	2020	For the same R, there was a decrease with H compared to V (HRb versus VR30 and VR40; and HR30 versus VR30 and VR40).	Arginine	13-14	ArfGAP with FG repeats 1	Homo sapiens	59-62
32581305-5	2020	Glycine (Gly) substituted by arginine (Arg) at position 43 (p.Gly43Arg) in PBK cosegregated with the disease in affected members of this family, but was absent in 180 normal control subjects from the same local population.	Arginine	29-37	PDZ binding kinase	Homo sapiens	75-78
32581305-5	2020	Glycine (Gly) substituted by arginine (Arg) at position 43 (p.Gly43Arg) in PBK cosegregated with the disease in affected members of this family, but was absent in 180 normal control subjects from the same local population.	Arginine	39-42	PDZ binding kinase	Homo sapiens	75-78
32479724-0	2020	Insights into the Sensitivity of Arginine Concentration to Preserve the Folded Form of Insulin Monomer Under Thermal Stress.	Arginine	33-41	insulin	Homo sapiens	87-94
32479724-2	2020	Driven by such controversial evidences, in this work we performed a series of atom- istic molecular dynamics simulations of insulin monomer, a biologically active hormone protein, in arginine solution of varying concentrations (0.5 M, 1 M, and 2 M) at am- bient and elevated temperature (400 K) to explore the arginine concentration driven structure-based stability of the protein.	Arginine	183-191	insulin	Homo sapiens	124-131
32479724-2	2020	Driven by such controversial evidences, in this work we performed a series of atom- istic molecular dynamics simulations of insulin monomer, a biologically active hormone protein, in arginine solution of varying concentrations (0.5 M, 1 M, and 2 M) at am- bient and elevated temperature (400 K) to explore the arginine concentration driven structure-based stability of the protein.	Arginine	310-318	insulin	Homo sapiens	124-131
32479724-5	2020	The replica-exchange MD (REMD) of insulin in 2 M arginine solution further supports the fact.	Arginine	49-57	insulin	Homo sapiens	34-41
32479724-9	2020	Importantly, apart from the protein-solvent hydrogen bonding in- teractions, the anion-pi interactions, established between the carboxyl group of arginine and the aromatic amino acid residues of insulin were recognized to facilitate the protein to maintain its native folded form at the experimental temperatures.	Arginine	146-154	insulin	Homo sapiens	195-202
32524920-1	2020	BACKGROUND: Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg).	Arginine	170-180	nitric oxide synthase 2	Homo sapiens	12-33
32524920-1	2020	BACKGROUND: Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg).	Arginine	170-175	nitric oxide synthase 2	Homo sapiens	12-33
32487995-4	2020	We report a dramatic reduction in serum amyloid A1 protein in ICM hearts, perturbed thyroid hormone signalling pathways and significant reductions in oxidoreductase co-factor riboflavin-5-monophosphate and glycolytic intermediate fructose-6-phosphate in both; unveil gender-specific changes in HF, including nitric oxide-related arginine metabolism, mitochondrial substrates, and X chromosome-linked protein and metabolite changes; and provide an interactive online application as a publicly-available resource.	Arginine	329-337	serum amyloid A1	Homo sapiens	34-50
32482183-2	2020	There is evidence that amino acids such as leucine, arginine and glutamine could stimulate the mammalian target of rapamycin (mTOR) pathway, which plays a pivotal role in primordial follicle activation.	Arginine	52-60	mechanistic target of rapamycin kinase	Homo sapiens	95-124
32482183-2	2020	There is evidence that amino acids such as leucine, arginine and glutamine could stimulate the mammalian target of rapamycin (mTOR) pathway, which plays a pivotal role in primordial follicle activation.	Arginine	52-60	mechanistic target of rapamycin kinase	Homo sapiens	126-130
32409599-4	2020	Here we show that in the presence of arginine, the arginine sensor ArgR, identified through this screen, directly activates expression of the genes encoding the T3SS.	Arginine	51-59	arginine repressor	Escherichia coli	67-71
32856018-1	2020	Background: Electrostatic complexes of poly (l-Arginine) (pArg) and hyaluronic acid (HA) have been investigated for their functional applications to supply free or polymeric form of l-Arginine (Arg) to target cells.	Arginine	45-55	poly(ADP-ribose) glycohydrolase	Homo sapiens	58-62
32592343-1	2020	BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer.	Arginine	124-132	tumor protein p53	Homo sapiens	56-60
32592343-1	2020	BACKGROUND: A transversion missense polymorphism of the TP53 tumor suppressor gene at the codon 72 codes proline instead of arginine causes an altered p53 protein expression and has been found to be associated with an elevated risk of various cancer; especially breast and lung cancer.	Arginine	124-132	tumor protein p53	Homo sapiens	151-154
32112882-0	2020	Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer.	Arginine	14-22	nitric oxide synthase 2	Homo sapiens	68-89
32112882-4	2020	We tested whether supplementing sepiapterin, the precursor of tetrahydrobiopterin (BH4)-the nitric oxide synthase (NOS) cofactor-redirects arginine metabolism from the pathway synthesizing polyamines to that of synthesizing nitric oxide (NO) and make breast tumors more immunogenic.	Arginine	139-147	nitric oxide synthase 2	Homo sapiens	92-113
32856018-1	2020	Background: Electrostatic complexes of poly (l-Arginine) (pArg) and hyaluronic acid (HA) have been investigated for their functional applications to supply free or polymeric form of l-Arginine (Arg) to target cells.	Arginine	47-50	poly(ADP-ribose) glycohydrolase	Homo sapiens	58-62
32856018-11	2020	At pH 7.4, pArg-HA iNCs released 30% of the total Arg-content, while at pH 5.0, 60% of Arg was released after 24 h. These electrostatically stabilized complexes were found to promote growth of human dermal fibroblasts (HDF) in wound-healing assay and increased nitric oxide (NO) activity in these cells in a time-dependent manner.	Arginine	50-53	poly(ADP-ribose) glycohydrolase	Homo sapiens	11-15
32547619-0	2020	Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests.	Arginine	56-64	growth hormone 1	Homo sapiens	84-98
31522785-10	2020	RESULTS: Pr-aCO2 increased only in the l-arginine group (p = 0.006), without a significant between-group difference (p = 0.17).	Arginine	39-49	aconitase 2	Homo sapiens	12-16
31522785-16	2020	Administration is safe with regard to global hemodynamics, but the observed increase in Pr-aCO2 and intra-abdominal pressure warrants careful application of l-arginine infusion and further research, especially in the early stage of septic shock.	Arginine	157-167	aconitase 2	Homo sapiens	91-95
32273272-4	2020	Insulin sensitivity and secretion were assessed by hyperinsulinemic-euglycemic clamp and arginine-stimulation testing in a subset of 8 TNDM participants and 7 relatives carrying genetic abnormalities, with and without diabetes, compared with 17 unrelated control subjects without diabetes.	Arginine	89-97	insulin	Homo sapiens	0-7
32424519-5	2020	The results indicate that the TP53 Arg/Pro heterozygosity (adjusted OR   2.32, 95% CI  1.28-4.34, p = 0.01), Pro/Pro mutant homozygosity (adjusted OR  4.15, 95% CI  1.75-9.86, p = 0.001), along with the combined genotype (Arg/Pro + Pro/Pro) (adjusted OR  2.83, 95% CI  1.61-4.97, p < 0.001) significantly increases the risk of cervical cancer.	Arginine	35-38	tumor protein p53	Homo sapiens	30-34
32424519-5	2020	The results indicate that the TP53 Arg/Pro heterozygosity (adjusted OR   2.32, 95% CI  1.28-4.34, p = 0.01), Pro/Pro mutant homozygosity (adjusted OR  4.15, 95% CI  1.75-9.86, p = 0.001), along with the combined genotype (Arg/Pro + Pro/Pro) (adjusted OR  2.83, 95% CI  1.61-4.97, p < 0.001) significantly increases the risk of cervical cancer.	Arginine	222-225	tumor protein p53	Homo sapiens	30-34
32356124-13	2020	Online protein structure predictions revealed that BRCA1 (3326A>T) mutations mutated AGA at this site to TGA resulting in a translated Arg (arginine) mutation as a stop codon, while BRCA2 (1342A>C) mutated AAT at this site to CAT resulting in a translated Asn mutation to His.	Arginine	135-138	catalase	Homo sapiens	226-229
32165314-1	2020	Insulin regulates the l-arginine/nitric oxide (NO) pathway in human umbilical vein endothelial cells (HUVECs), increasing the plasma membrane expression of the l-arginine transporter hCAT-1 and inducing vasodilation in umbilical and placental veins.	Arginine	22-32	insulin	Homo sapiens	0-7
32165314-3	2020	The aim of this study was to determine the contribution of KCa channels in both insulin-induced l-arginine transport and NO synthesis, and its relationship with placental vascular relaxation.	Arginine	96-106	insulin	Homo sapiens	80-87
32456215-2	2020	Importantly, our previous work demonstrated that PRMT5 overexpression could substantially augment activation of the nuclear factor kappa B (NF-kappaB) via methylation of arginine 30 (R30) on its p65 subunit, while knockdown of PRMT5 showed the opposite effect.	Arginine	170-178	protein arginine methyltransferase 5	Homo sapiens	49-54
32478190-8	2020	The result revealed 94.9% polymorphism of PON1 Q192R, which was higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes.	Arginine	83-86	paraoxonase 1	Homo sapiens	42-46
32456215-2	2020	Importantly, our previous work demonstrated that PRMT5 overexpression could substantially augment activation of the nuclear factor kappa B (NF-kappaB) via methylation of arginine 30 (R30) on its p65 subunit, while knockdown of PRMT5 showed the opposite effect.	Arginine	170-178	nuclear factor kappa B subunit 1	Homo sapiens	116-138
32131024-2	2020	One such role ascribed to arginase has been that of regulating nitric oxide (NO) production by a substrate (l-arginine) competition between arginase and nitric oxide synthase (NOS).	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	153-174
32456215-2	2020	Importantly, our previous work demonstrated that PRMT5 overexpression could substantially augment activation of the nuclear factor kappa B (NF-kappaB) via methylation of arginine 30 (R30) on its p65 subunit, while knockdown of PRMT5 showed the opposite effect.	Arginine	170-178	nuclear factor kappa B subunit 1	Homo sapiens	140-149
32478190-8	2020	The result revealed 94.9% polymorphism of PON1 Q192R, which was higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes.	Arginine	87-90	paraoxonase 1	Homo sapiens	42-46
32429593-0	2020	The MKK-Dependent Phosphorylation of p38alpha Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.	Arginine	62-70	mitogen-activated protein kinase 14	Homo sapiens	37-45
32430022-7	2020	RESULTS: The carriers of the C allele (Arg at 64th position was encoded by the C allele) had higher levels of leptin and lower levels of adiponectin than the non-carriers.	Arginine	39-42	adiponectin, C1Q and collagen domain containing	Homo sapiens	137-148
32429593-11	2020	Together, this study unveils a novel regulatory mechanism of p38alpha activation via protein arginine methylation on R49/R149 by PRMT1, which impacts partner interaction and thus promotes erythroid differentiation.	Arginine	93-101	mitogen-activated protein kinase 14	Homo sapiens	61-69
32032598-10	2020	Overall, our data for the first time provide evidence that kappa-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to MI/R injury via STAT3-OPA1 pathway.	Arginine	163-164	signal transducer and activator of transcription 3	Mus musculus	176-181
32397647-1	2020	Hexameric arginine repressor, ArgR, is the feedback regulator of bacterial L-arginine regulons, and sensor of L-arg that controls transcription of genes for its synthesis and catabolism.	Arginine	10-18	arginine repressor	Escherichia coli	30-34
32397647-1	2020	Hexameric arginine repressor, ArgR, is the feedback regulator of bacterial L-arginine regulons, and sensor of L-arg that controls transcription of genes for its synthesis and catabolism.	Arginine	75-85	arginine repressor	Escherichia coli	30-34
32397647-1	2020	Hexameric arginine repressor, ArgR, is the feedback regulator of bacterial L-arginine regulons, and sensor of L-arg that controls transcription of genes for its synthesis and catabolism.	Arginine	75-80	arginine repressor	Escherichia coli	30-34
32397647-2	2020	Although ArgR function, as well as its secondary, tertiary, and quaternary structures, is essentially the same in E. coli and B. subtilis, the two proteins differ significantly in sequence, including residues implicated in the response to L-arg.	Arginine	239-244	arginine repressor	Escherichia coli	9-13
32397647-7	2020	The dynamic consequences of L-arg binding for transcriptional activation of intact ArgR are evaluated here for the first time in two-microsecond simulations of B. subtilis ArgR.	Arginine	28-33	arginine repressor	Escherichia coli	83-87
32397647-7	2020	The dynamic consequences of L-arg binding for transcriptional activation of intact ArgR are evaluated here for the first time in two-microsecond simulations of B. subtilis ArgR.	Arginine	28-33	arginine repressor	Escherichia coli	172-176
32397647-8	2020	L-arg binding to intact B. subtilis ArgR causes a significant further shift in the angle of rotation between trimers that causes the N-terminal DNA-binding domains lose their interactions with the C-terminal domains, and is likely the first step toward adopting DNA-binding-competent conformations.	Arginine	0-5	arginine repressor	Escherichia coli	36-40
32062385-8	2020	RESULTS: At 72 h after the induction of AP with l-arginine, significantly lower levels of serum amylase, lipase, TNF-alpha, and IL-1beta were observed in KO mice when compared with WT controls.	Arginine	48-58	tumor necrosis factor	Mus musculus	113-122
32543134-1	2020	Objective: TRAIL-Mu3 was obtained by mutating the N-terminus of human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene to an eight continuous arginine sequence.	Arginine	162-170	TNF superfamily member 10	Homo sapiens	11-16
32388084-0	2020	Arctium lappa root extract containing L-arginine prevents TNF-alpha-induced early atherosclerosis in vitro and in vivo.	Arginine	38-48	tumor necrosis factor	Mus musculus	58-67
32388084-8	2020	Notably, L-arginine suppressed TNF-alpha-induced monocyte adhesion to HUVECs.	Arginine	9-19	tumor necrosis factor	Mus musculus	31-40
31502681-4	2020	l-Arginine, being a substrate for iNOS, is the natural lead to develop iNOS inhibitors.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	34-38
31502681-4	2020	l-Arginine, being a substrate for iNOS, is the natural lead to develop iNOS inhibitors.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	71-75
32216867-5	2020	A 1021 argI1 null mutant lacked arginase activity and grew at a drastically reduced rate with arginine as sole nitrogen source.	Arginine	94-102	arginase	Sinorhizobium meliloti 1021	7-12
32216867-7	2020	In the wild-type, arginase activity and argI1 transcription were induced several fold by exogenous arginine.	Arginine	99-107	arginase	Sinorhizobium meliloti 1021	40-45
32216867-11	2020	A Lrp-like regulator (smc03092) divergently transcribed from argI1 was required for arginase induction by arginine or ornithine.	Arginine	106-114	arginase	Sinorhizobium meliloti 1021	61-66
32216867-14	2020	Our results indicate that ArgI1 is the sole arginase in S. meliloti, that it contributes substantially to arginine catabolism in vivo and that argI1 induction by arginine is dependent on ArgIR.	Arginine	106-114	arginase	Sinorhizobium meliloti 1021	26-31
32216867-14	2020	Our results indicate that ArgI1 is the sole arginase in S. meliloti, that it contributes substantially to arginine catabolism in vivo and that argI1 induction by arginine is dependent on ArgIR.	Arginine	162-170	arginase	Sinorhizobium meliloti 1021	26-31
32216867-14	2020	Our results indicate that ArgI1 is the sole arginase in S. meliloti, that it contributes substantially to arginine catabolism in vivo and that argI1 induction by arginine is dependent on ArgIR.	Arginine	162-170	arginase	Sinorhizobium meliloti 1021	143-148
32123042-4	2020	We found that Tyr 96, Glu 201, Arg 204, and Trp 234 in the presumptive active site of JIP60 are conserved in 815 plant RIPs in the Pfam database that were identified by HUMMR as containing a RIP domain.	Arginine	31-34	Protein synthesis inhibitor II	Hordeum vulgare	119-122
32165496-5	2020	pncRNA-D was highly m6A-methylated in control cells, but osmotic stress reduced the methylation and also arginine methylation of TLS in the nucleus.	Arginine	105-113	FUS RNA binding protein	Homo sapiens	129-132
32353864-2	2020	NEI-01 was designed as a novel arginine-depleting enzyme comprising an albumin binding domain capable of binding to human serum albumin to lengthen its half-life.	Arginine	31-39	albumin	Homo sapiens	122-135
32326637-4	2020	Several reported CaM interactors lack these anchors but contain Lys/Arg-rich polybasic sequences adjacent to a lipidated N- or C-terminus.	Arginine	68-71	calmodulin 1	Homo sapiens	17-20
32191634-2	2020	Based on recent observations that PRMT5 and arginine methylation is upregulated in activated memory T cells, we hypothesized that PRMT5 is involved in the pathogenesis of aGVHD.	Arginine	44-52	protein arginine methyltransferase 5	Homo sapiens	130-135
32494626-4	2020	Here, we found a small-molecule compound CYD19 that forms a high-affinity interaction with the evolutionarily conserved arginine-174 pocket of Snail protein.	Arginine	120-128	snail family transcriptional repressor 1	Homo sapiens	143-148
32290120-12	2020	The favorable effects of Arg were abrogated when an iNOS inhibitor was administered, which indicated that NO may be participated in regulating the homeostasis of Th/Treg cells and subsequent liver inflammation during sepsis.	Arginine	25-28	nitric oxide synthase 2, inducible	Mus musculus	52-56
32015149-6	2020	Furthermore, the fusion of beta-lactamase C-terminal to the FecR transmembrane helix results in translocation of the C-terminal domain that is dependent on the twin-arginine translocation (Tat) system.	Arginine	165-173	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	189-192
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Arginine	97-105	Beta-lactamase	Escherichia coli	11-16
32015149-11	2020	As such, FecR represents a new class of bitopic Tat-dependent membrane proteins with an internal twin-arginine signal sequence.	Arginine	102-110	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	48-51
32025719-0	2020	PRMT5-mediated histone arginine methylation antagonizes transcriptional repression by polycomb complex PRC2.	Arginine	23-31	protein arginine methyltransferase 5	Homo sapiens	0-5
32283586-5	2020	We have earlier shown that KSHV ORF59, viral processivity factor, binds to a protein arginine methyl transferase 5 (PRMT5) to alter the histone arginine methylation during reactivation.	Arginine	85-93	protein arginine methyltransferase 5	Homo sapiens	116-121
31996893-2	2020	WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the "WIN" site) showing efficacy against a range of cancer cell lines in vitro.	Arginine	111-119	WD repeat domain 5	Homo sapiens	0-4
31996893-2	2020	WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the "WIN" site) showing efficacy against a range of cancer cell lines in vitro.	Arginine	111-119	WD repeat domain 5	Homo sapiens	138-142
32060017-2	2020	RESEARCH DESIGN AND METHODS: A Stepped Insulin Secretion Test with Arginine was used to quantify functional beta-cell capacity by hyperglycemia and arginine stimulation.	Arginine	67-75	insulin	Homo sapiens	39-46
32006292-5	2020	Postload beta-cell function was measured by 2-hour C-peptide (2hCP) and the acute C-peptide response (ACPR) to arginine.	Arginine	111-119	insulin	Homo sapiens	82-91
32006292-8	2020	CONCLUSIONS: ACPR evaluated by the arginine stimulation test may be superior to other commonly used beta-cell function parameters to reflect glycemic fluctuation in insulin-treated patients with type 2 diabetes.	Arginine	35-43	insulin	Homo sapiens	165-172
32087767-3	2020	With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the four Arg/N-degron-dependent ubiquitin ligases, UBR1, UBR2, UBR4, and UBR5, we demonstrated decreased cell migration and proliferation and increased spontaneous apoptosis in cancer cells.	Arginine	107-110	ubiquitin protein ligase E3 component n-recognin 5	Mus musculus	171-175
32007273-4	2020	We show here that rat LGP85 is polyubiquitinated at the N-terminal short cytoplasmic domain that comprises of only three amino acid residues, alanine, arginine, and cysteine.	Arginine	151-159	scavenger receptor class B, member 2	Rattus norvegicus	22-27
32169720-9	2020	The RT-PCR analysis confirmed the modifications of Fibrillin-1, ADAMTSL4, Basigin and Xanthine Oxidase, whose expression levels increase after stimulation with LPS and are reduced by l-Arginine (p < 0.05).	Arginine	183-193	fibrillin 1	Bos taurus	51-62
32025719-1	2020	Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
32309436-9	2020	In addition, we observed that the apoptotic index of cells with H/R stimulation was reduced when NCMs were pretreated with PERK-rAAV9, Nrf2-rAAV9, or HO-1-rAAV9.	Arginine	66-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
31469916-4	2020	We found PRMT6 to methylate CRAF at arginine 100, interfere with its RAS/RAF binding potential and as a result alter ERK-mediated PKM2 translocation into the nucleus.	Arginine	36-44	protein arginine methyltransferase 6	Homo sapiens	9-14
32309436-9	2020	In addition, we observed that the apoptotic index of cells with H/R stimulation was reduced when NCMs were pretreated with PERK-rAAV9, Nrf2-rAAV9, or HO-1-rAAV9.	Arginine	66-67	heme oxygenase 1	Mus musculus	150-154
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Arginine	116-119	coagulation factor II, thrombin	Homo sapiens	12-20
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Arginine	116-119	coagulation factor II, thrombin	Homo sapiens	93-101
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Arginine	155-158	coagulation factor II, thrombin	Homo sapiens	12-20
32011145-1	2020	Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg.	Arginine	155-158	coagulation factor II, thrombin	Homo sapiens	93-101
32256584-6	2020	HIF-1 signaling pathway modulating P-glycoproteins expression, PI3K-Akt pathway regulating survivin expression, and oxidative phosphorylation were upregulated, while arginine and proline metabolism regulating NO production and glycolysis/gluconeogenesis were downregulated during osimertinib resistance.	Arginine	166-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
31895699-3	2020	All groups with detectable MMTT C-peptide demonstrated acute C-peptide and proinsulin responses to arginine that were positively correlated with peak MMTT C-peptide (P < 0.0001 for both analytes).	Arginine	99-107	insulin	Homo sapiens	32-41
31895699-3	2020	All groups with detectable MMTT C-peptide demonstrated acute C-peptide and proinsulin responses to arginine that were positively correlated with peak MMTT C-peptide (P < 0.0001 for both analytes).	Arginine	99-107	insulin	Homo sapiens	75-85
32197481-1	2020	Nitric oxide (NO ), synthesized from L-arginine by nitric oxide synthase (NOS), is involved in sperm functionality.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	51-72
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	87-90	agouti related neuropeptide	Mus musculus	46-50
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	154-157	agouti related neuropeptide	Mus musculus	46-50
32292506-9	2020	Consistently, the promoters of this gene cohort were enriched for both PRMT5-mediated symmetric di-methylation of histone H4 on Arg 3 (H4R3me2s) and c-Myc, and c-Myc depletion also upregulated their expression.	Arginine	128-131	protein arginine methyltransferase 5	Homo sapiens	71-76
31764069-10	2020	At 4 weeks, INSTI-treated patients had gained on average 40 CD4 cells/mul (P = 0.05) over PI/r-treated ones; mean CD4 counts were similar in the two groups at 48 weeks.	Arginine	19-20	CD4 molecule	Homo sapiens	60-63
31779731-3	2020	Results showed that dietary supplementation of 1 0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group.	Arginine	53-56	T cell receptor gamma constant 1	Homo sapiens	231-253
31779731-3	2020	Results showed that dietary supplementation of 1 0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group.	Arginine	53-56	troponin C1, slow skeletal and cardiac type	Homo sapiens	262-267
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	PPARG coactivator 1 alpha	Homo sapiens	66-95
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	PPARG coactivator 1 alpha	Homo sapiens	97-107
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	cytochrome c, somatic	Homo sapiens	124-136
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	PPARG coactivator 1 alpha	Homo sapiens	175-185
32420297-9	2020	Arg-96 is a critical amino acid enhancing anonaine, isolaureline-FTO binding.	Arginine	0-3	FTO, alpha-ketoglutarate dependent dioxygenase	Rattus norvegicus	65-68
32188159-0	2020	Effect of Arginine on Chaperone-Like Activity of HspB6 and Monomeric 14-3-3zeta.	Arginine	10-18	heat shock protein family B (small) member 6	Homo sapiens	49-79
32188159-2	2020	A significant increase in the anti-aggregation activity of HspB6 and 14-3-3zetam was demonstrated in the presence of 0.1 M arginine (Arg).	Arginine	123-131	heat shock protein family B (small) member 6	Homo sapiens	59-64
32188159-2	2020	A significant increase in the anti-aggregation activity of HspB6 and 14-3-3zetam was demonstrated in the presence of 0.1 M arginine (Arg).	Arginine	133-136	heat shock protein family B (small) member 6	Homo sapiens	59-64
32188159-5	2020	The changes in the structures of HspB6 and 14-3-3zetam induced by binding of Arg were evaluated by the fluorescence spectroscopy and differential scanning calorimetry.	Arginine	77-80	heat shock protein family B (small) member 6	Homo sapiens	33-38
31641819-8	2020	Pre-treatment with ARG and/or CAR significantly mitigated the neural changes induced by hypoxia and attenuated the elevated levels of NF-kappaB, TNF-alpha, IL-6, caspase-3, and BAX, while ameliorated the reduced levels of Bcl-2, NADR, DOP, SER, and GABA, with the best improvement observed with the combination.	Arginine	19-22	tumor necrosis factor	Rattus norvegicus	145-154
32144153-0	2020	Withdrawal: Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.	Arginine	76-84	BTG3 associated nuclear protein	Homo sapiens	29-34
32144153-0	2020	Withdrawal: Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.	Arginine	76-84	tumor protein p53	Homo sapiens	60-63
32226302-2	2020	NO is mainly produced from L-arginine by inducible NO synthase (iNOS).	Arginine	27-37	nitric oxide synthase 2	Homo sapiens	41-62
32226302-2	2020	NO is mainly produced from L-arginine by inducible NO synthase (iNOS).	Arginine	27-37	nitric oxide synthase 2	Homo sapiens	64-68
32064872-0	2020	L-arginine ameliorates lipopolysaccharide-induced intestinal inflammation through inhibiting the TLR4/NF-kappaB and MAPK pathways and stimulating beta-defensins expression in vivo and in vitro.	Arginine	0-10	nuclear factor kappa B subunit 1	Homo sapiens	102-111
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	interleukin 6	Homo sapiens	110-114
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	C-X-C motif chemokine ligand 8	Homo sapiens	133-137
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	tumor necrosis factor	Homo sapiens	186-195
32064872-5	2020	Furthermore, L-arginine diminished the LPS-induced expression of toll-like receptor 4 (TLR4) and inhibited activation of TLR4-mediated nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	Arginine	13-23	nuclear factor kappa B subunit 1	Homo sapiens	135-157
32064872-5	2020	Furthermore, L-arginine diminished the LPS-induced expression of toll-like receptor 4 (TLR4) and inhibited activation of TLR4-mediated nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	Arginine	13-23	nuclear factor kappa B subunit 1	Homo sapiens	159-168
32064872-6	2020	Importantly, we proposed a new mechanism that L-arginine had the ability to stimulate the expression of porcine epithelial beta-defensins through activating the mammalian target of rapamycin (mTOR) pathway, which exerts anti-inflammatory influence.	Arginine	46-56	mechanistic target of rapamycin kinase	Homo sapiens	161-190
32064872-6	2020	Importantly, we proposed a new mechanism that L-arginine had the ability to stimulate the expression of porcine epithelial beta-defensins through activating the mammalian target of rapamycin (mTOR) pathway, which exerts anti-inflammatory influence.	Arginine	46-56	mechanistic target of rapamycin kinase	Homo sapiens	192-196
32064872-8	2020	The present study indicated L-arginine enhanced disease resistance through inhibiting the TLR4/NF-kappaB and MAPK pathways and partially, possibly through increasing the intestinal beta-defensins expression.	Arginine	28-38	nuclear factor kappa B subunit 1	Homo sapiens	95-104
32267121-9	2020	Further investigation revealed that the addition of 240 microg/ml of arginine into the culture medium of LMH cells infected with FAdV-4 for 24 hr led to a significant increase in the mRNA levels of iNOS but a significant reduction in the viral load of FAdV-4.	Arginine	69-77	nitric oxide synthase 2	Gallus gallus	198-202
31665349-10	2020	In exposed subjects, insulin secretion during graded IV glucose infusion and after arginine administration decreased by 17% (P = 0.02) and 22% (P = 0.002), respectively, while glucagon secretion after arginine increased.	Arginine	201-209	glucagon	Homo sapiens	176-184
31641819-8	2020	Pre-treatment with ARG and/or CAR significantly mitigated the neural changes induced by hypoxia and attenuated the elevated levels of NF-kappaB, TNF-alpha, IL-6, caspase-3, and BAX, while ameliorated the reduced levels of Bcl-2, NADR, DOP, SER, and GABA, with the best improvement observed with the combination.	Arginine	19-22	interleukin 6	Rattus norvegicus	156-160
31641819-8	2020	Pre-treatment with ARG and/or CAR significantly mitigated the neural changes induced by hypoxia and attenuated the elevated levels of NF-kappaB, TNF-alpha, IL-6, caspase-3, and BAX, while ameliorated the reduced levels of Bcl-2, NADR, DOP, SER, and GABA, with the best improvement observed with the combination.	Arginine	19-22	BCL2, apoptosis regulator	Rattus norvegicus	222-227
32010934-9	2020	Direct sequencing revealed a heterozygous c. 34 C>T variation in the alphaA-crystallin protein (CRYAA) gene, which resulted in the replacement of a highly conserved arginine by cystine at codon 12 (p.R12C).	Arginine	165-173	crystallin alpha A	Homo sapiens	96-101
31838061-12	2020	Overexpressing NKILA led to the suppression of the NF-kappaB pathway and successfully prevented the cell apoptosis and inflammatory responses caused by H/R stimulation in H9c2 cells.	Arginine	154-155	NF-kappaB interacting lncRNA	Homo sapiens	15-20
32092898-8	2020	In the myocardium, in response to cellular injury, an arginine-specific mono-ADP-ribosylation cycle, involving ART1 and ARH1, regulated the level and cellular distribution of ADP-ribosylated tripartite motif-containing protein 72 (TRIM72).	Arginine	54-62	ADP-ribosyltransferase 1	Homo sapiens	111-115
32029006-12	2020	Purified T cells showed declined re-expression of CD3zeta when co-cultured with peritoneal cells from infected mice, and CD3zeta was regenerated by supplement of L-arginine or arginase inhibitor BEC, rather than NOS inhibitor L-NMMA or catalase.	Arginine	162-172	CD247 antigen	Mus musculus	121-128
32041521-6	2020	RESULTS: Based on a list of colour genes of the International Federation of Pigment Cell Societies, a non-synonymous mutation with exchange of a glycine residue at position 291 of the tyrosinase protein by arginine was identified as the cause of dilution of the coat colour.	Arginine	206-214	tyrosinase	Bos taurus	184-194
32117246-4	2020	However, LL-37 is known to be susceptible to the enzymatic activity of peptidyl arginine deiminases (PAD), and exposure of the peptide to these enzymes results in the conversion of positively charged arginines to neutral citrullines (citrullination).	Arginine	200-209	cathelicidin antimicrobial peptide	Homo sapiens	9-14
31765670-0	2020	Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.	Arginine	21-29	protein arginine methyltransferase 5	Homo sapiens	6-11
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	29-37	protein arginine methyltransferase 5	Homo sapiens	68-73
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	279-287	protein arginine methyltransferase 5	Homo sapiens	68-73
32761572-6	2020	Glutamine, arginine and D-aspartate also exert their muscle effects through mTOR.	Arginine	11-19	mechanistic target of rapamycin kinase	Homo sapiens	76-80
31759053-2	2020	The 92nd arginine to glutamine mutation (R92Q) of cTnT was one of the mutant hotspots in hypertrophic cardiomyopathy (HCM).	Arginine	9-17	troponin T2, cardiac type	Homo sapiens	50-54
31870966-6	2020	In addition, supplementation of l-arginine to DDAH-1 KO rats was used to explore the role of DDAH-1 in regulating NO.	Arginine	32-42	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	46-52
31822509-3	2020	We identified enrichment of histone 3 dimethylation at Arg-8 (H3(Me2)R8) in the promoter regions of miR33b, miR96, and miR503.	Arginine	55-58	microRNA 96	Homo sapiens	108-113
31822509-3	2020	We identified enrichment of histone 3 dimethylation at Arg-8 (H3(Me2)R8) in the promoter regions of miR33b, miR96, and miR503.	Arginine	55-58	microRNA 503	Homo sapiens	119-125
31953250-0	2020	Correction: A nitric oxide synthase-like protein from Synechococcus produces NO/NO3 - from l-arginine and NADPH in a tetrahydrobiopterin- and Ca2+-dependent manner.	Arginine	91-101	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
31909745-2	2020	TRX from the extremely halophilic archaeon Halobacterium salinarum NRC-1 (HsTRX-A), which has the highest acidic residue content [(Asp + Glu)/(Arg + Lys + His) = 9.0] among known TRXs, was chosen to elucidate the catalytic mechanism and evolutionary characteristics associated with haloadaptation.	Arginine	143-146	thioredoxin family protein	Halobacterium salinarum NRC-1	0-3
31667789-1	2020	Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) with two added excipients, L-arginine and niacinamide, to ensure formulation stability with accelerated initial absorption after subcutaneous administration compared with previously developed rapid-acting insulins.	Arginine	95-105	insulin	Homo sapiens	12-19
31647043-7	2020	l-Arg also decreased the expression of arginase II in the ileum, arginine:glycine amidinotransferase in the liver and the kidney and glyoxalase I in the liver, ileum and brain, but increased the expression of arginine decarboxylase and polyamines levels in the liver.	Arginine	0-5	glyoxalase 1	Rattus norvegicus	133-145
31814314-1	2020	OBJECTIVE: Biallelic variants in RARS1, encoding the cytoplasmic tRNA synthetase for arginine (ArgRS), cause a hypomyelinating leukodystrophy.	Arginine	85-93	arginyl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-100
31672462-2	2020	NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	60-81
31000813-7	2020	PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2.	Arginine	44-52	SUFU negative regulator of hedgehog signaling	Mus musculus	101-105
31672462-2	2020	NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).	Arginine	23-33	nitric oxide synthase 3	Homo sapiens	138-153
31672462-2	2020	NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	186-199
31672462-2	2020	NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	201-205
32306315-8	2020	An arginine-containing buffer is essential for the elution of bacterially expressed PTX3 N-terminal domain to minimize aggregation.	Arginine	3-11	pentraxin 3	Homo sapiens	84-88
31192483-1	2020	A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l-arginine.	Arginine	210-220	nitric oxide synthase 2	Homo sapiens	132-163
31192483-1	2020	A considerable number of human diseases have an inflammatory component, and a key mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS), which produces nitric oxide (NO) from l-arginine.	Arginine	210-220	nitric oxide synthase 2	Homo sapiens	165-169
32814314-3	2020	It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO and citrulline.	Arginine	117-125	nitric oxide synthase 3	Homo sapiens	39-62
32814314-3	2020	It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO and citrulline.	Arginine	117-125	nitric oxide synthase 3	Homo sapiens	64-68
33202416-10	2020	Arginine-stimulated insulin and glucagon release showed no pre- to postoperative change.	Arginine	0-8	insulin	Homo sapiens	20-27
32115479-2	2020	NO was a widely noted gas with diverse functions, having arginine (L-Arg) as a substrate for the NO synthase (NOS).	Arginine	57-65	nitric oxide synthase 2	Homo sapiens	97-108
32115479-2	2020	NO was a widely noted gas with diverse functions, having arginine (L-Arg) as a substrate for the NO synthase (NOS).	Arginine	67-72	nitric oxide synthase 2	Homo sapiens	97-108
32416844-1	2020	N-carbamylglutamate (NCG), an analogue of N-acetyl-L-glutamate (NAG), can increase arginine synthesis in mammals and improve the reproductive performance.	Arginine	83-91	neuroblastoma amplified sequence	Gallus gallus	64-67
31642121-5	2020	Using this tool, we have identified a putative domain enriched in hydrophilic and disorder-promoting residues (Pro, Ser, and Thr) and depleted in positive charges (Arg and Lys) bordering the folded DNA-binding domains of several transcription factors (p53, GCR, NAC46, MYB28, and MYB29).	Arginine	164-167	tumor protein p53	Homo sapiens	252-255
31642121-5	2020	Using this tool, we have identified a putative domain enriched in hydrophilic and disorder-promoting residues (Pro, Ser, and Thr) and depleted in positive charges (Arg and Lys) bordering the folded DNA-binding domains of several transcription factors (p53, GCR, NAC46, MYB28, and MYB29).	Arginine	164-167	nuclear receptor subfamily 3 group C member 1	Homo sapiens	257-260
32454488-9	2020	Arg-II knockout enhances Arg-I expression and activity, but inhibits interleukin (IL)-6 expression and secretion and reduces active p38mapk in aging adipose tissue macrophages and stromal cells.	Arginine	0-3	interleukin 6	Mus musculus	69-87
31780028-0	2019	Effect of l-arginine supplementation on C-reactive protein and other inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.	Arginine	10-20	C-reactive protein	Homo sapiens	40-58
33148838-5	2020	RESULTS: Results: It has been established that individuals with mutant genotypes Arg/Gln of TLR-2, Leu/Phe, Phe/Phe of TLR-3, Asp/Gly of TLR-4 genes have a vaccinal response to administering anti-influenza vaccine at the level of subjects with normal distribution of TLR alleles, as evidenced by the growth in dynamics of mean geometric titers of antibodies to vaccine strains, the level of seroprotection and seroconversion.	Arginine	81-84	toll like receptor 2	Homo sapiens	92-97
31189070-4	2019	We sought to determine the role of l-arginine uptake via SLC6A14 in modifying F508del-CFTR channel activity in airway cells from patients with cystic fibrosis (CF).	Arginine	35-45	CF transmembrane conductance regulator	Homo sapiens	86-90
31189070-9	2019	l-arginine uptake via SLC6A14 augmented F508del-CFTR function at baseline and after treatment with lumacaftor.	Arginine	0-10	CF transmembrane conductance regulator	Homo sapiens	48-52
31189070-12	2019	In summary, SLC6A14-mediated l-arginine transport augments residual F508del-CFTR channel function via a noncanonical, NO pathway.	Arginine	29-39	CF transmembrane conductance regulator	Homo sapiens	76-80
31733991-5	2019	The interface also sandwiches a critical Set1 arginine-rich motif (ARM) that autoinhibits COMPASS.	Arginine	46-54	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	41-45
31780028-1	2019	OBJECTIVES: We carried out a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of L-arginine on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6) and TNFalpha.	Arginine	128-138	C-reactive protein	Homo sapiens	176-194
31780028-7	2019	However, when subgroup analysis was performed, we found that L-arginine supplementation increased CRP levels in subjects with ages >60 years old, participants with baseline circulating CRP levels >3 mg/dl, patients with cancer and when used in enteral formula.	Arginine	61-71	C-reactive protein	Homo sapiens	98-101
31780028-7	2019	However, when subgroup analysis was performed, we found that L-arginine supplementation increased CRP levels in subjects with ages >60 years old, participants with baseline circulating CRP levels >3 mg/dl, patients with cancer and when used in enteral formula.	Arginine	61-71	C-reactive protein	Homo sapiens	185-188
31780028-8	2019	CONCLUSION: Results of the present meta-analysis indicated that L-arginine supplementation increased the circulating concentrations of CRP in subjects with ages >60 years old, subjects with higher levels of CRP, patients with cancer and when used in enteral formula.	Arginine	64-74	C-reactive protein	Homo sapiens	135-138
31780028-8	2019	CONCLUSION: Results of the present meta-analysis indicated that L-arginine supplementation increased the circulating concentrations of CRP in subjects with ages >60 years old, subjects with higher levels of CRP, patients with cancer and when used in enteral formula.	Arginine	64-74	C-reactive protein	Homo sapiens	207-210
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	AKT serine/threonine kinase 1	Homo sapiens	156-159
31032902-7	2019	Mechanistically, TGFbeta-induced Snail1 promotes the epigenetic mark of asymmetrically dimethylated arginine.	Arginine	100-108	snail family transcriptional repressor 1	Homo sapiens	33-39
31576512-0	2019	L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway.	Arginine	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	138-142
31576512-5	2019	This study tested the hypothesis that L-arginine regulates the TJ network by activating AMP-activated protein kinase (AMPK) signaling, which in turn improves intestinal barrier functions under HS.	Arginine	38-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	88-116
31576512-5	2019	This study tested the hypothesis that L-arginine regulates the TJ network by activating AMP-activated protein kinase (AMPK) signaling, which in turn improves intestinal barrier functions under HS.	Arginine	38-48	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	118-122
31576512-11	2019	According to KEGG pathway analysis, L-arginine activated the AMPK signaling pathway.	Arginine	36-46	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	61-65
31576512-15	2019	L-Arginine had the same effect as AICAR both in vitro and in vivo, namely increasing p-AMPK protein expression.	Arginine	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	87-91
31576512-16	2019	L-Arginine and AICAR also upregulated the mRNA expression level of HSP70 and HSP90, and downregulated mRNA expression of MLCK (P < 0.05).	Arginine	0-10	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	77-82
31576512-16	2019	L-Arginine and AICAR also upregulated the mRNA expression level of HSP70 and HSP90, and downregulated mRNA expression of MLCK (P < 0.05).	Arginine	0-10	myosin light chain kinase 3	Rattus norvegicus	121-125
31576512-18	2019	Our findings indicate that activation of AMPK signaling by L-arginine is associated with improved intestinal mucosal barrier functions by enhancing the expression of TJs in rat small intestines and IEC-6 cells during HS.	Arginine	59-69	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	41-45
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	mitogen-activated protein kinase 1	Homo sapiens	165-202
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	mitogen-activated protein kinase 1	Homo sapiens	204-207
31683975-7	2019	In current users of beta2-agonists, the risk of COPD exacerbation decreased by 30% (hazard ratio (HR); 0.70, 95% CI: 0.59-0.84) for each copy of the Arg allele of rs1042713 and by 20% (HR; 0.80, 95% CI: 0.69-0.94) for each copy of the Gln allele of rs1042714.	Arginine	149-152	G protein-coupled receptor 162	Homo sapiens	20-25
31496325-11	2019	Meanwhile, OMT inhibited Arg-induced expression of CD44 and CD55 in intestinal injury.	Arginine	25-28	CD55 molecule (Cromer blood group)	Rattus norvegicus	60-64
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	C-reactive protein	Homo sapiens	81-99
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	C-reactive protein	Homo sapiens	101-104
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	tumor necrosis factor	Homo sapiens	107-134
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	tumor necrosis factor	Homo sapiens	136-145
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	interleukin 6	Homo sapiens	151-164
31699008-2	2021	Recently, scientists studied L-arginine effect on inflammatory mediators such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6).	Arginine	29-39	interleukin 6	Homo sapiens	166-170
31699008-10	2021	L-arginine could not reduce inflammatory mediators among patients with and without cancer except one article which indicated that taking L-arginine for 6 months decreased IL-6 among cardiopathic nondiabetic patients.	Arginine	137-147	interleukin 6	Homo sapiens	171-175
31504841-4	2019	OBJECTIVE: The review was performed to answer the following research question: "In VPNs, are high amounts of arginine in PN, compared with low amounts of arginine, associated with appropriate circulating concentrations of arginine?"	Arginine	109-117	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	84-86
31504841-5	2019	Therefore, the aims were to 1) quantify the relationship between parenteral arginine intakes and plasma arginine concentrations in PN-dependent VPNs; 2) identify any features of study design that affect this relationship; and 3) estimate the target parenteral arginine dose to achieve desirable preterm plasma arginine concentrations.	Arginine	76-84	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	131-133
31504841-5	2019	Therefore, the aims were to 1) quantify the relationship between parenteral arginine intakes and plasma arginine concentrations in PN-dependent VPNs; 2) identify any features of study design that affect this relationship; and 3) estimate the target parenteral arginine dose to achieve desirable preterm plasma arginine concentrations.	Arginine	104-112	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	131-133
31504841-5	2019	Therefore, the aims were to 1) quantify the relationship between parenteral arginine intakes and plasma arginine concentrations in PN-dependent VPNs; 2) identify any features of study design that affect this relationship; and 3) estimate the target parenteral arginine dose to achieve desirable preterm plasma arginine concentrations.	Arginine	104-112	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	131-133
31504841-5	2019	Therefore, the aims were to 1) quantify the relationship between parenteral arginine intakes and plasma arginine concentrations in PN-dependent VPNs; 2) identify any features of study design that affect this relationship; and 3) estimate the target parenteral arginine dose to achieve desirable preterm plasma arginine concentrations.	Arginine	104-112	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	131-133
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	tumor necrosis factor	Rattus norvegicus	77-86
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	interleukin 6	Rattus norvegicus	88-92
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	interleukin 1 beta	Rattus norvegicus	94-102
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	Eph receptor B1	Rattus norvegicus	170-173
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	tumor necrosis factor	Rattus norvegicus	202-211
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	interleukin 6	Rattus norvegicus	213-217
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	interleukin 1 beta	Rattus norvegicus	219-227
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	Eph receptor B1	Rattus norvegicus	251-254
31445222-3	2019	At 25 days, IGF1 gene was more expressed in embryos from ARG than in embryos from control gilts (CON) (P = 0.05).	Arginine	57-60	insulin like growth factor 1	Homo sapiens	12-16
31445222-6	2019	These results indicate that duration of supplementation is determinant for arginine effects, not only on the females performance but also on the conceptuses, since supplementation upregulated IGF1 expression at 25 days, in addition to the reduction of cephalic-caudal length of 35-day fetuses.	Arginine	75-83	insulin like growth factor 1	Homo sapiens	192-196
31747921-11	2019	Pravastatin induces the placental microsomal arginine uptake leading to the rapid activation of eNOS independently of Ser1177 phosphorylation.	Arginine	45-53	nitric oxide synthase 3	Homo sapiens	96-100
31558604-8	2019	We propose that IGF-1 Glu-58 interacts with IGF-1R Arg-704 and belongs to IGF-1 site 1, a finding supported by the NMR structure of the less active Asp-58-IGF-1 variant.	Arginine	51-54	insulin like growth factor 1	Homo sapiens	16-21
31722313-2	2019	ADAR2 regulates Ca<sup>2+</sup> influx through alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors via adenosine-to-inosine conversion at the glutamine/arginine site of GluA2 mRNA, which makes ADAR2 a key factor in acquired Ca<sup>2+</sup> resistance in motor neurons.	Arginine	175-183	adenosine deaminase, RNA-specific, B1	Mus musculus	0-5
31492697-2	2019	To check wheth er peptides built exclusively from arginine residues will interact with different nAChR subtypes or with such their structural homologues as the acetylcholine binding protein and ligand binding domain of nAChR alpha9 subunit, we synthesized a series of R3, R6, R8 and R16 oligoarginines and investigate their activity by competition with radioiodinated alpha- bungarotoxin, by two electrode voltage clamp electrophysiology and calcium imaging.	Arginine	50-58	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	97-102
31653061-1	2019	Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus.	Arginine	102-105	prolactin releasing hormone	Homo sapiens	0-27
31654065-6	2019	Angiotensin II can reduce l-arginine transport and hence NO production.	Arginine	26-36	angiotensinogen	Homo sapiens	0-14
31653061-1	2019	Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus.	Arginine	102-105	prolactin releasing hormone	Homo sapiens	29-33
31624244-5	2019	Furthermore, we show that UHRF1 interacts with PRMT5, an arginine methyltransferase, to regulate the repressive histone arginine modifications (H4R3me2s and H3R2me2s), and cooperates with the PIWI pathway during spermatogenesis.	Arginine	57-65	protein arginine methyltransferase 5	Homo sapiens	47-52
31519807-0	2019	The lncRNA hsromega regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila.	Arginine	30-38	FUS RNA binding protein	Homo sapiens	62-65
31519807-3	2019	Here, we show that knockdown of the Drosophila lncRNA hsromega causes a shift in the methylation status of human FUS from mono- (MMA) to di-methylated (DMA) arginine via upregulation of the arginine methyltransferase 5 (PRMT5, known as ART5 in flies).	Arginine	157-165	FUS RNA binding protein	Homo sapiens	113-116
31519807-3	2019	Here, we show that knockdown of the Drosophila lncRNA hsromega causes a shift in the methylation status of human FUS from mono- (MMA) to di-methylated (DMA) arginine via upregulation of the arginine methyltransferase 5 (PRMT5, known as ART5 in flies).	Arginine	157-165	protein arginine methyltransferase 5	Homo sapiens	220-225
30485425-5	2019	Inhibition of arginine metabolism enhanced the proliferation and cytotoxicity of anti-NY-ESO T cells against AZA/VOR treated AML blasts, and can boost anti-CD33 Chimeric Antigen Receptor-T cell cytotoxicity.	Arginine	14-22	CD33 molecule	Homo sapiens	156-160
31352175-4	2019	Our results showed that levels of ERbeta and PGR expression were significantly increased by nutrient restriction, but L-Arg counteracted the effect of nutrient restriction on ERbeta and PGR expression (p < 0.05).	Arginine	118-123	estrogen receptor beta	Ovis aries	175-181
31533925-1	2019	Protein arginine methyltransferase 5 (Prmt5), a type II arginine methyltransferase, symmetrically dimethylates arginine in nuclear and cytoplasmic proteins.	Arginine	8-16	protein arginine methyltransferase 5	Danio rerio	38-43
31533925-5	2019	Moreover, arginine methylation of the germ-cell-specific proteins Zili and Vasa, as well as histones H3 (H3R8me2s) and H4 (H4R3me2s), was reduced in the gonads of prmt5-null zebrafish.	Arginine	10-18	protein arginine methyltransferase 5	Danio rerio	163-168
31352175-9	2019	The expression levels of endothelial nitric oxide synthase, ERbeta, and PGR were significantly increased in response to low-concentration (200 mumol) L-Arg supplementation, which subsequently decreased with a high concentration (800 mumol) (p < 0.05).	Arginine	150-155	nitric oxide synthase, endothelial	Ovis aries	25-58
31533925-8	2019	Our results revealed a novel mechanism associated with prmt5, i.e., prmt5 apparently controls germ cell development in vertebrates by catalyzing arginine methylation of the germline-specific proteins Zili and Vasa.	Arginine	145-153	protein arginine methyltransferase 5	Danio rerio	55-60
31533925-8	2019	Our results revealed a novel mechanism associated with prmt5, i.e., prmt5 apparently controls germ cell development in vertebrates by catalyzing arginine methylation of the germline-specific proteins Zili and Vasa.	Arginine	145-153	protein arginine methyltransferase 5	Danio rerio	68-73
31352175-9	2019	The expression levels of endothelial nitric oxide synthase, ERbeta, and PGR were significantly increased in response to low-concentration (200 mumol) L-Arg supplementation, which subsequently decreased with a high concentration (800 mumol) (p < 0.05).	Arginine	150-155	estrogen receptor beta	Ovis aries	60-66
31037357-3	2019	Therefore, this study assesses PIM recruitment in the lungs of a mouse model of acute necrotizing pancreatitis (ANP) induced with L-arginine monohydrochloride.	Arginine	130-158	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	31-34
31492752-5	2019	A p53 mutant with arginine substitutions of its 18 lysine residues was not ubiquitinated.	Arginine	18-26	tumor protein p53	Homo sapiens	2-5
31254933-2	2019	The porcine alpha1,3 galactosyltransferase (alpha1,3 GT) induce the hyperacute rejection by synthesizing Galalpha1-3Galbeta1-(3)4GlcNAc-R (alphaGal) on the surface of graft endothelial cells (ECs) during xeno-transplantation.	Arginine	135-137	BCL2 related protein A1	Homo sapiens	44-55
30872107-6	2019	Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart (IAsp) containing the excipients niacinamide and L-arginine.	Arginine	133-143	insulin	Homo sapiens	12-19
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	57-65	fms related receptor tyrosine kinase 3	Homo sapiens	49-53
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	57-65	fms related receptor tyrosine kinase 3	Homo sapiens	141-145
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	33-34	fms related receptor tyrosine kinase 3	Homo sapiens	49-53
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	33-34	fms related receptor tyrosine kinase 3	Homo sapiens	141-145
31395602-10	2019	These results indicate that abolishing FLT3 arginine methylation through PRMT1 inhibition represents a promising strategy to target MLL-r ALL cells.	Arginine	44-52	fms related receptor tyrosine kinase 3	Homo sapiens	39-43
31330236-9	2019	Specifically, we identified a conserved arginine (R107) residue in the turn of beta3 and beta4 sheet in the C-terminus of the DBD of HsfA1a that is highly conserved in plant HsfA1 proteins, but is replaced by leucine and cysteine in tomato HsfA1c and HsfA1e, respectively.	Arginine	40-48	heat shock factor protein HSF8	Solanum lycopersicum	133-139
31307994-4	2019	We suggest that NEP-based BNP cleavage at position 17-18 results in BNP ring opening and formation of a novel epitope with C-terminal Arg-17 (BNP-neo17 form).	Arginine	134-137	membrane metalloendopeptidase	Homo sapiens	16-19
31485918-7	2019	Fast-acting insulin aspart is a modified formulation of insulin aspart containing niacinamide and L-arginine.	Arginine	98-108	insulin	Homo sapiens	12-19
31485918-7	2019	Fast-acting insulin aspart is a modified formulation of insulin aspart containing niacinamide and L-arginine.	Arginine	98-108	insulin	Homo sapiens	56-63
31218444-2	2019	CPM catalytic domain hydrolyzes Arg from C-terminal peptides (i.e., bradykinin and kallidin), generating des-Arg-kinins, the agonists of B1 receptor (B1R).	Arginine	32-35	carboxypeptidase M	Mus musculus	0-3
31218444-2	2019	CPM catalytic domain hydrolyzes Arg from C-terminal peptides (i.e., bradykinin and kallidin), generating des-Arg-kinins, the agonists of B1 receptor (B1R).	Arginine	32-35	bradykinin receptor, beta 1	Mus musculus	137-154
31427400-4	2019	Now, we show that the addition of arginine together with inhibition of intracellular arginase activity increased cytosolic nitric oxide and enhanced the rescue effect of ORKAMBI on F508del-CFTR-mediated chloride conductance at the cell surface of patient-derived bronchial and nasal epithelial cultures.	Arginine	34-42	CF transmembrane conductance regulator	Homo sapiens	189-193
31427400-8	2019	In this case, we observed enhancement of pharmacologically rescued F508del-CFTR by arginine-dependent, nitric oxide signaling through inhibition of endogenous arginase activity.	Arginine	83-91	CF transmembrane conductance regulator	Homo sapiens	75-79
31437685-7	2019	The homozygous mutant-type TLR2 Gln/Gln (A/A) was represented to be associated with the occurrence of RH (P = 0.04) and conferred a 9 fold risk for susceptibility, while the heterozygous mutant-type TLR2 Arg/Gln (G/A) indicated a tendency to be associated with the occurrence of RH (P = 0.07).	Arginine	204-207	toll like receptor 2	Homo sapiens	27-31
31292260-8	2019	Conversely, noncanonical SR protein Serine-arginine repetitive matrix 2/3/4 (Srrm234) is a main determinant of exon inclusion in the Dscam exon 9 cluster.	Arginine	43-51	Down syndrome cell adhesion molecule 1	Drosophila melanogaster	133-138
31146155-9	2019	The LC-PCB sulfates formed hydrogen bond interaction with arginine 228 residue of TRalpha by their sulfate groups, which might facilitate the TR binding and agonistic activity.	Arginine	58-66	pyruvate carboxylase	Homo sapiens	7-10
31300852-6	2019	Arginine prevented biofilm formation by reducing FLO11 gene expression; its addition did not affect cell viability and was even found to enhance cell metabolism (vitality marker) as determined by phenotype microarray (PM) analysis.	Arginine	0-8	Flo11p	Saccharomyces cerevisiae S288C	49-54
31429546-3	2019	Here, we compared downregulation and deletion of the transcriptional repressor ArgR in arginine overproducing Escherichia coli.	Arginine	87-95	arginine repressor	Escherichia coli	79-83
31429546-5	2019	Metabolomics and proteomics data revealed that poor growth of the ArgR deletion strain was caused by a limitation of pyrimidine nucleotide biosynthesis, because a 17-fold overexpression of ornithine carbamoyltransferase (ArgI) perturbed the arginine-pyrimidine branch point.	Arginine	241-249	arginine repressor	Escherichia coli	66-70
31616317-0	2019	Effect of L-Arginine on Titin Expression in Rat Soleus Muscle After Hindlimb Unloading.	Arginine	10-20	titin	Rattus norvegicus	24-29
31616317-8	2019	Furthermore, L-arginine administration under unloading resulted in increased titin mRNA level (by 76%, p &lt; 0.05) and decreased phosphorylation level of T2 (by 28%, p &lt; 0.05), compared to those in the HS group.	Arginine	13-23	titin	Rattus norvegicus	77-82
31616317-9	2019	These results suggest that administration of L-arginine, the NO precursor, under unloading decreased the degree of atrophy changes, increased gene expression of titin and prevented the decrease in levels of T1 in the rat soleus muscle.	Arginine	45-55	titin	Rattus norvegicus	161-166
31226655-11	2019	The NF-kappaB inhibitory effect depended on the N-terminal cysteine and the neighboring Arg-Ser-Ala-Gly-Ser-Ile (RSAGSI) domain of NF-kappaB.	Arginine	88-91	nuclear factor kappa B subunit 1	Homo sapiens	4-13
31226655-11	2019	The NF-kappaB inhibitory effect depended on the N-terminal cysteine and the neighboring Arg-Ser-Ala-Gly-Ser-Ile (RSAGSI) domain of NF-kappaB.	Arginine	88-91	nuclear factor kappa B subunit 1	Homo sapiens	131-140
33455163-4	2019	In this study, we uncover the interaction between an angiopoietin-1 mimetic peptide, QHREDGS (glutamine-histidine-arginine-glutamic acid-aspartic acid-glycine-serine), immobilized to a collagen-chitosan hydrogel, and murine bone marrow derived macrophages.	Arginine	114-122	angiopoietin 1	Mus musculus	53-67
30980288-7	2019	In conclusion, phenylalanine, arginine, and lysine were found to affect the nucleation phase of lysozyme aggregation and could be considered as suitable stabilizing structures for this enzyme.	Arginine	30-38	lysozyme	Homo sapiens	96-104
31533268-1	2019	Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS).	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	95-106
31411472-7	2019	The model clearly disambiguates the position of the Arg-195 sidechain disputed previously and shows a number of interactions for loop C, both with the ar/R filter and a number of other residues on the extracellular side of hAQP1.	Arginine	52-55	aquaporin 1 (Colton blood group)	Homo sapiens	223-228
31500090-3	2019	Nitric oxide (NO) is a free radical synthesized from L-arginine by the action of the NO synthase (NOS) enzyme.	Arginine	53-63	nitric oxide synthase 2	Homo sapiens	85-96
31409663-0	2019	Triple arginines as molecular determinants for pentameric assembly of the intracellular domain of 5-HT3A receptors.	Arginine	7-16	5-hydroxytryptamine receptor 3A	Homo sapiens	98-104
31300852-0	2019	The administration of L-cysteine and L-arginine inhibits biofilm formation in wild-type biofilm-forming yeast by modulating FLO11 gene expression.	Arginine	37-47	Flo11p	Saccharomyces cerevisiae S288C	124-129
30267646-7	2019	Similarly, by cleaving mono-ADP-ribosylated arginine on target proteins, ARH1 appears to inhibit tumor formation, suggesting that ARH1 is a tumor-suppressor gene.	Arginine	44-52	ADP-ribosylarginine hydrolase	Mus musculus	73-77
30267646-7	2019	Similarly, by cleaving mono-ADP-ribosylated arginine on target proteins, ARH1 appears to inhibit tumor formation, suggesting that ARH1 is a tumor-suppressor gene.	Arginine	44-52	ADP-ribosylarginine hydrolase	Mus musculus	130-134
31116442-7	2019	The adolescents were re-examined after 3 months off rhGH using both IGF-1 and GHRH-arginine tests.	Arginine	83-91	growth hormone releasing hormone	Homo sapiens	78-82
31385938-6	2019	The more recently developed fast-acting insulin aspart (faster aspart) is an ultrafast-acting mealtime insulin that contains the conventional insulin aspart in a new formulation with the excipients niacinamide and L-arginine to achieve faster insulin absorption than RHI and the conventional insulin aspart formulation.	Arginine	214-224	insulin	Homo sapiens	40-47
31144428-1	2019	Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart (IAsp) containing the additional excipients niacinamide and L-arginine.	Arginine	144-154	insulin	Homo sapiens	12-19
31474872-6	2019	Silencing HIF1alpha, but not HIF2alpha, reversed hypoxia-induced upregulation of Arg-II.	Arginine	81-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-19
31656992-10	2019	Copeptin reliably differentiates various entities of the polyuria polydipsia syndrome; baseline levels >20 pmol/L without prior fluid deprivation identify patients with nephrogenic diabetes insipidus, whereas levels measured upon osmotic stimulation with hypertonic saline or upon non-osmotic stimulation with arginine differentiate primary polydipsia from central diabetes insipidus.	Arginine	310-318	arginine vasopressin	Homo sapiens	0-8
31439799-4	2019	Nuclear magnetic resonance spectroscopy of FMRP-CAPRIN1 condensates revealed interactions involving arginine-rich and aromatic-rich regions.	Arginine	100-108	cell cycle associated protein 1	Homo sapiens	48-55
31248335-8	2019	Using mass spectrometry and in vitro studies, we found that r-huPAD4 citrullinates ADAMTS13 on specific arginine residues and that this modification dramatically inhibits ADAMTS13 enzymatic activity.	Arginine	104-112	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	83-91
31309634-7	2019	Distinct from other identified CBG-binding sequences, an arginine residue flanking the KXL motif of ORC1 inserts into a neighboring acidic pocket, contributing to the strong ORC1-Cyclin A association.	Arginine	57-65	serpin family A member 6	Homo sapiens	31-34
31309634-7	2019	Distinct from other identified CBG-binding sequences, an arginine residue flanking the KXL motif of ORC1 inserts into a neighboring acidic pocket, contributing to the strong ORC1-Cyclin A association.	Arginine	57-65	cyclin A2	Homo sapiens	179-187
31446431-8	2019	Together, our results show that the apoptotic effect of Abeta peptides is linked to their impairment of Ate1 catalytic activity leading to suppression of the Arg/N-end rule pathway proteolytic activity and ultimately cell death.	Arginine	158-161	arginyltransferase 1	Mus musculus	104-108
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	40-43	formyl peptide receptor 1	Homo sapiens	108-138
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	40-43	formyl peptide receptor 1	Homo sapiens	140-144
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	48-51	formyl peptide receptor 1	Homo sapiens	108-138
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	48-51	formyl peptide receptor 1	Homo sapiens	140-144
31408619-3	2019	Here, we identify that inhibiting symmetric or asymmetric dimethylation of arginine, mediated by PRMT5 and type I protein arginine methyltransferases (PRMTs), respectively, reduces splicing fidelity and results in preferential killing of SF-mutant leukemias over wild-type counterparts.	Arginine	75-83	protein arginine methyltransferase 5	Homo sapiens	97-102
31314511-5	2019	In contrast to the arginine-enriched mutant (7KR) scFv exhibited strong reversible association.	Arginine	19-27	immunglobulin heavy chain variable region	Homo sapiens	50-54
31314511-7	2019	Studies of single-point arginine to lysine scFv mutants indicated that the observed aggregation propensity of arginine under denaturing conditions was nonspecific.	Arginine	110-118	immunglobulin heavy chain variable region	Homo sapiens	43-47
31314511-8	2019	Interestingly, one such swap generated a scFv with especially low aggregation rates under low/high ionic strengths and denaturing buffers; molecular modeling identified hydrogen bonding between the arginine side chain and main chain peptide groups, stabilizing the structure.	Arginine	198-206	immunglobulin heavy chain variable region	Homo sapiens	41-45
31579486-8	2019	Taken together, we suggest that iNOS inhibitor can be a novel treatment for the prevention and treatment of vitiligo by combination of NBUVB therapy, furthermore; NO agents like L-arginine could also increase the effectiveness of phototherapy.	Arginine	178-188	nitric oxide synthase 2, inducible	Mus musculus	32-36
31428367-9	2019	Conclusions: Arginine prevented C. perfringens challenge-induced circulated arginine deficiency, normalized intestinal arginine transport and catabolism, down-regulated JAK-STAT signalling pathway and attenuated the inflammatory response, which exerted protective effects on the intestine of broiler chickens.	Arginine	13-21	Janus kinase 3	Gallus gallus	169-172
31390828-5	2019	The most potent PRMT1 inhibitor, compound 9a, displayed non-competitive pattern with respect to either SAM or substrate arginine, and showed the strong selectivity to PRMT1 compared to PRMT5, which belongs to the type II PRMT family.	Arginine	120-128	protein arginine methyltransferase 5	Homo sapiens	185-190
31217189-0	2019	PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.	Arginine	20-28	fms related receptor tyrosine kinase 3	Homo sapiens	15-19
31290614-0	2019	Roles of the Conserved Amino Acid Residues in Reduced Human Defensin 5: Cysteine and Arginine Are Indispensable for Its Antibacterial Action and LPS Neutralization.	Arginine	85-93	defensin alpha 5	Homo sapiens	60-70
31230395-2	2019	Preclinical and clinical studies indicate that insulin and C-peptide levels measured after intravenous administration of the beta cell secretagogue arginine can be used to estimate the available islet mass.	Arginine	148-156	insulin	Homo sapiens	47-54
31177555-5	2019	RESULTS: An association with the T allele of rs11575542 coding for an arginine to glutamine substitution in the L-aromatic amino acid decarboxylase (AADC) enzyme was replicated in a meta-analysis of 3 independent cohorts.	Arginine	70-78	dopa decarboxylase	Homo sapiens	149-153
31101937-2	2019	Three predominant types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric (Rme2s/SDMA), and asymmetric (Rme2a/ADMA).	Arginine	27-35	monocyte to macrophage differentiation associated	Homo sapiens	87-90
31378783-5	2019	PRMT3 activated the expression of miR-3648 by enhancing histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) levels at promoter region of the gene.	Arginine	67-75	protein arginine methyltransferase 3	Homo sapiens	0-5
30950230-4	2019	We previously demonstrated that overexpression of mutant FGFR1-25R (25 out of 29 intracellular lysines replaced with arginine) results in enhanced receptor recycling as compared to wild-type FGFR1 followed by strong stimulation of elongative axon growth in vitro.	Arginine	117-125	fibroblast growth factor receptor 1	Homo sapiens	57-62
31230395-7	2019	The acute insulin response to arginine (AIRarg) was not significantly correlated with IEQ (r = 0.38, P = 0.095) or IPN (r = 0.41, P = 0.071).	Arginine	30-38	insulin	Homo sapiens	10-17
31267554-0	2019	Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	58-63
31150637-3	2019	Positively charged arginine (R) and histidine (H) of mouse AQP0 ELA and ELC were substituted individually with glutamine (Q) to create R33Q, H40Q, R113Q and H122Q by mutagenesis.	Arginine	19-27	major intrinsic protein of lens fiber	Mus musculus	59-63
31088907-1	2019	We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant of codon 72 (R72) of TP53 and that R72 increases the risk for angiomyolipoma.	Arginine	138-146	tumor protein p53	Homo sapiens	176-180
30205752-7	2019	We further found that Lys, Glu, Gln, Asn, and Arg residues shared the major contribution toward the intermolecular interactions in XPA homo-dimers.	Arginine	46-49	XPA, DNA damage recognition and repair factor	Homo sapiens	131-134
30633341-1	2019	Serine-arginine protein kinase 1 (SRPK1) is the main regulator in alternative splicing by phosphorylating splicing factors rich in serine/arginine repeats.	Arginine	7-15	serine/arginine-rich protein specific kinase 1	Mus musculus	34-39
31312965-1	2019	Protein arginine methyltransferase 5 (PRMT5) is responsible for the mono-methylation and symmetric dimethylation of arginine, and its expression level and methyl transferring activity have been demonstrated to have a close relationship with tumorigenesis, development and poor clinical outcomes of human cancers.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
31147442-3	2019	JMJD6 is also reported to catalyze N-demethylation of N-methylated (both mono- and di-methylated) arginine residues of histones and other proteins, including HSP70 (heat-shock protein 70), estrogen receptor alpha, and RNA helicase A.	Arginine	98-106	estrogen receptor 1	Homo sapiens	189-212
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Arginine	85-88	tumor protein p53	Homo sapiens	33-37
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Arginine	89-92	tumor protein p53	Homo sapiens	33-37
31369573-5	2019	RESULTS: The allele frequency of TP53 codon 72 in our cohort was 37, 42, and 21% for Arg/Arg, Arg/Pro, and Pro/Pro, respectively.	Arginine	89-92	tumor protein p53	Homo sapiens	33-37
31369573-8	2019	In NMIBC, FGFR1 expression was higher in patients without the Arg allele and FGFR3 expression was higher in patients with the Arg allele.	Arginine	62-65	fibroblast growth factor receptor 1	Homo sapiens	10-15
31022534-1	2019	Nitric oxide synthase (NOS) catalyzes the transformation of l-arginine, molecular oxygen (O2), and NADPH-derived electrons to nitric oxide (NO) and l-citrulline.	Arginine	60-70	nitric oxide synthase 2	Homo sapiens	0-21
30953277-7	2019	In del6, the mutation causes a substitution of the glutamine (Gln) for the conserved basic amino acid arginine (Arg) in the NLS of the SBP domain, and disrupts the normal nuclear localization and function of SPL9.	Arginine	112-115	squamosa promoter binding protein-like 9	Arabidopsis thaliana	208-212
31417499-0	2019	Accuracy and Limitations of the Growth Hormone (GH) Releasing Hormone-Arginine Retesting in Young Adults With Childhood-Onset GH Deficiency.	Arginine	70-78	growth hormone 1	Homo sapiens	32-46
31417499-0	2019	Accuracy and Limitations of the Growth Hormone (GH) Releasing Hormone-Arginine Retesting in Young Adults With Childhood-Onset GH Deficiency.	Arginine	70-78	growth hormone 1	Homo sapiens	48-50
31366981-7	2019	Further analysis of the highly similar Cr-AGO2 and Cr-AGO 3 sequences (90% amino acid identity) revealed a glycine-arginine rich N-terminal extension of ~100 amino acids that, given previous work on unicellular protists, may associate AGO with the translation machinery.	Arginine	115-123	uncharacterized protein	Chlamydomonas reinhardtii	54-59
31360909-2	2019	Inhibitors of an arginine-binding cavity in WDR5, known as the WDR5-interaction (WIN) site, have been proposed to selectively kill MLL-rearranged malignancies via an epigenetic mechanism.	Arginine	17-25	WD repeat domain 5	Homo sapiens	44-48
31360909-2	2019	Inhibitors of an arginine-binding cavity in WDR5, known as the WDR5-interaction (WIN) site, have been proposed to selectively kill MLL-rearranged malignancies via an epigenetic mechanism.	Arginine	17-25	WD repeat domain 5	Homo sapiens	63-67
31337005-3	2019	NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS.	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	0-12
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Arginine	99-102	ring finger protein 34	Homo sapiens	10-15
31363388-8	2019	Sanger sequencing of proband"s DNA identified mutation of HNF1A at codon 203 which changed amino acid from arginine to cysteine (R203C).	Arginine	107-115	HNF1 homeobox A	Homo sapiens	58-63
31337005-3	2019	NO synthases (NOS) use l-arginine (Arg) as a substrate, as asymmetric dimethylarginine (ADMA) is a direct endogenous inhibitor of NOS.	Arginine	35-38	nitric oxide synthase 2	Homo sapiens	0-12
30973645-13	2019	CONCLUSIONS: In a large group of previously GH-treated young adults with PWS, approximately 1 in 7 exhibited a GH peak &lt;9 mug/L during a GHRH-arginine test.	Arginine	145-153	growth hormone releasing hormone	Homo sapiens	140-144
31396302-9	2019	IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA.	Arginine	37-47	interleukin 6	Homo sapiens	0-4
31396302-9	2019	IL-6 was an independent predictor of L-arginine/ADMA, VEGF-A of ADMA, G-CSF of L-arginine/SDMA, and GM-CSF of L-citrulline and SDMA.	Arginine	79-89	interleukin 6	Homo sapiens	0-4
31354664-0	2019	Competitive Repression of the artPIQM Operon for Arginine and Ornithine Transport by Arginine Repressor and Leucine-Responsive Regulatory Protein in Escherichia coli.	Arginine	49-57	arginine repressor	Escherichia coli	85-103
31354664-5	2019	Whereas repression by ArgR requires arginine as corepressor, repression of P artP by Lrp is partially counteracted by leucine, its major effector molecule.	Arginine	36-44	arginine repressor	Escherichia coli	22-26
31354664-11	2019	Direct arginine and ArgR-dependent repression of lrp could be observed with a 25-bp deletion mutant, in which the ArgR binding site was artificially moved to a position immediately downstream of the lrp transcription initiation site.	Arginine	7-15	arginine repressor	Escherichia coli	114-118
31287990-2	2019	Using a combination of GSK3368715 with PRMT5 inhibitors, the authors show that a threshold of overall arginine methylation reduction needs to be achieved for synergistic anti-tumor activity.	Arginine	102-110	protein arginine methyltransferase 5	Homo sapiens	39-44
32184956-3	2020	Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors.	Arginine	114-117	proopiomelanocortin	Homo sapiens	135-139
32184956-3	2020	Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors.	Arginine	114-117	STAM binding protein	Homo sapiens	140-149
31103260-7	2019	These results suggest that Hsp70/CHIP chaperone-mediated protein degradation system is crucial in the regulation of PRMT5-v2 turnover, which has the potential to balance the symmetrical arginine dimethylation in cells.	Arginine	186-194	heat shock protein 1B	Mus musculus	27-32
31155767-10	2019	Activator of transcription 3 (STAT3) mRNA expression was linearly reduced with increasing ARG (p &lt; 0.05), the transcriptional repressor B-cell lymphoma 6 (BCL6) mRNA expression was quadratically (p &lt; 0.05) responded, and these cytokines had the lowest expression at 19.1 g/kg.	Arginine	90-93	signal transducer and activator of transcription 3	Gallus gallus	30-35
31155767-11	2019	ARG supplementation (&gt;14.7 g/kg) did not significantly improve the growth performance, while it may have a potential negative regulatory effect on B-cell-mediated humoral immunity in chickens associated with suppression of the STAT3 expression associated with the JAK/STAT3 pathway.	Arginine	0-3	signal transducer and activator of transcription 3	Gallus gallus	230-235
31155767-11	2019	ARG supplementation (&gt;14.7 g/kg) did not significantly improve the growth performance, while it may have a potential negative regulatory effect on B-cell-mediated humoral immunity in chickens associated with suppression of the STAT3 expression associated with the JAK/STAT3 pathway.	Arginine	0-3	Janus kinase 3	Gallus gallus	267-270
30963326-2	2019	Mpr1 protects yeast cells from oxidative stresses possibly by activating a novel L-arginine biosynthesis.	Arginine	81-91	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
31249870-2	2019	Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism.	Arginine	36-44	protein arginine methyltransferase 5	Homo sapiens	66-71
31068428-8	2019	However, alteration of Q428 to an arginine or lysine resulted in markedly greater resistance to eCD4-Ig and CD4-Ig, with correspondingly dramatic losses in infectivity and greater sensitivity to a V3 antibody and to serum from an infected individual.	Arginine	34-42	CD4 molecule	Homo sapiens	97-100
30956113-2	2019	Although arginine is metabolically important, the physiological arginine sensor that activates mTOR remains unclear.	Arginine	64-72	mechanistic target of rapamycin kinase	Homo sapiens	95-99
30956113-4	2019	TM4SF5 bound active mTOR upon arginine sufficiency and constitutively bound amino acid transporter SLC38A9.	Arginine	30-38	mechanistic target of rapamycin kinase	Homo sapiens	20-24
31217904-9	2019	We also show that YY1 is a substrate of CARM1 mediated arginine methylation, where the latter could coactivate YY1 mediated reporter gene activation in vivo.	Arginine	55-63	YY1 transcription factor	Homo sapiens	18-21
30916320-9	2019	Together, these findings demonstrate that there is a degree of redundancy between the PRMT5 and PRMT1 pathways, even though these two enzymes deposit different types of arginine methylation marks.	Arginine	169-177	protein arginine methyltransferase 5	Homo sapiens	86-91
31217904-9	2019	We also show that YY1 is a substrate of CARM1 mediated arginine methylation, where the latter could coactivate YY1 mediated reporter gene activation in vivo.	Arginine	55-63	YY1 transcription factor	Homo sapiens	111-114
31160378-0	2019	Robust repression of tRNA gene transcription during stress requires protein arginine methylation.	Arginine	76-84	mitochondrially encoded tRNA glycine	Homo sapiens	21-25
31155612-8	2019	In mAoSMCs from ApoE-null mice fed a high-cholesterol diet (ApoE-/- +HCD), Arg activity was increased, and spermine concentration was higher than that of wild-type mice.	Arginine	75-78	apolipoprotein E	Mus musculus	16-20
31155612-8	2019	In mAoSMCs from ApoE-null mice fed a high-cholesterol diet (ApoE-/- +HCD), Arg activity was increased, and spermine concentration was higher than that of wild-type mice.	Arginine	75-78	apolipoprotein E	Mus musculus	60-64
30802296-6	2019	The remaining enzymes, Adam19 and Furin, were found to be capable of cleavage at arginine residues, and inhibitors for both proteases were added to cell-free media to determine if the product degradation could be reduced.	Arginine	81-89	LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 19	Cricetulus griseus	23-29
30849519-8	2019	A lys151 to arginine mutant of TTF1 (TTF1K151R) is resistant to PMA- or HECW1-mediated ubiquitination and degradation.	Arginine	12-20	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	Homo sapiens	72-77
30903920-2	2019	PRMT5 is the major type II arginine methyltransferase that catalyzes the transfer of two methyl groups symmetrically to the arginine residues of either histone or non-histone proteins.	Arginine	27-35	protein arginine methyltransferase 5	Homo sapiens	0-5
30861422-5	2019	To antagonize intracellular MDM2/MDMX for p53 activation, we extended this protein, PMIBcr/Abl, by a C-terminal Arg-repeating hexapeptide to facilitate its cellular uptake.	Arginine	112-115	tumor protein p53	Homo sapiens	42-45
30417362-9	2019	Our results demonstrated that under the Abeta treatment, ornithine decarboxylase (ODC), a rate-limiting enzyme in the regulation of arginine catabolism, regulates microglial activation by altering the antizyme (AZ) + 1 ribosomal frameshift.	Arginine	132-140	amyloid beta precursor protein	Homo sapiens	40-45
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	DOT1 like histone lysine methyltransferase	Homo sapiens	39-44
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	DOT1 like histone lysine methyltransferase	Homo sapiens	118-123
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	DOT1 like histone lysine methyltransferase	Homo sapiens	118-123
30649354-0	2019	Function of essential chloride and arginine residue in nucleotide binding to vesicular nucleotide transporter.	Arginine	35-43	solute carrier family 17 member 9	Homo sapiens	77-109
30649354-6	2019	Here, we examined the functional roles of Cl- and essential arginine residue on ATP binding to VNUT using the fluorescent ATP analogue trinitrophenyl-ATP (TNP-ATP).	Arginine	60-68	solute carrier family 17 member 9	Homo sapiens	95-99
31015230-6	2019	C/EBPalpha associated with and was methylated by PRMT1 at three arginine residues (R35, R156, and R165).	Arginine	64-72	CCAAT enhancer binding protein alpha	Homo sapiens	0-10
30937466-10	2019	The former one is mainly related to inflammatory inhibition and protection of the PKB-eNOS signaling pathway; whereas the latter one is associated with the addition of the L-arginine substrate of eNOS, arginase inhibition, and the supplement of tetrahydrobiopterin, which can elevate no level.	Arginine	172-182	nitric oxide synthase 3	Homo sapiens	196-200
30511344-8	2019	The receptor-based molecular docking exposed the best binding interaction of Notch-1 with ganoderic acid A with GScore (- 8.088), kcal/mol, Lipophilic EvdW (- 1.74), Electro (- 1.18), Glide emodel (- 89.944) with the active participation of Arg 189, Arg 199, Glu 232 residues.	Arginine	241-244	notch receptor 1	Homo sapiens	77-84
31015037-9	2019	In conclusion, sequential activation of LOX-1, JNK, and L-arginine consuming enzyme arginase-I in diabetes elicits superoxide-dependent oxidative stress and impairs endothelial NO-mediated dilation in coronary arterioles.	Arginine	56-66	arginase 1	Sus scrofa	84-94
30511344-8	2019	The receptor-based molecular docking exposed the best binding interaction of Notch-1 with ganoderic acid A with GScore (- 8.088), kcal/mol, Lipophilic EvdW (- 1.74), Electro (- 1.18), Glide emodel (- 89.944) with the active participation of Arg 189, Arg 199, Glu 232 residues.	Arginine	250-253	notch receptor 1	Homo sapiens	77-84
30902834-5	2019	Overexpression of SseK1 greatly broadened substrate specificity, whereas ectopic co-expression of SseK1 and TRADD increased the range of modified arginine residues within the death domain of TRADD.	Arginine	146-154	TNFRSF1A associated via death domain	Homo sapiens	108-113
30808730-7	2019	We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous pyrimidines partially rescues the impairment in cell growth.	Arginine	70-78	epidermal growth factor receptor	Homo sapiens	13-17
30902834-5	2019	Overexpression of SseK1 greatly broadened substrate specificity, whereas ectopic co-expression of SseK1 and TRADD increased the range of modified arginine residues within the death domain of TRADD.	Arginine	146-154	TNFRSF1A associated via death domain	Homo sapiens	191-196
30922994-2	2019	In activated microglia, l-arginine is metabolized competitively by inducible nitric oxide synthase (iNOS) and arginase (Arg), which then synthesize NO or polyamines, respectively.	Arginine	24-34	nitric oxide synthase 2, inducible	Mus musculus	67-98
31007021-0	2019	Transepithelial Transport Route and Liposome Encapsulation of Milk-Derived ACE-Inhibitory Peptide Arg-Leu-Ser-Phe-Asn-Pro.	Arginine	98-101	angiotensin I converting enzyme	Homo sapiens	75-78
29737046-4	2019	The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs.	Arginine	92-95	BCL2 related protein A1	Homo sapiens	34-41
31000626-6	2019	We noted that in both crystal structures, the linker tethering indomethacin to the dansyl moiety passes through the constriction at the mouth of the COX-2 active site, resulting in displacement and disorder of Arg-120, located at the opening to the active site.	Arginine	210-213	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Arginine	13-16	tumor protein p53	Homo sapiens	0-4
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Arginine	13-16	tumor protein p53	Homo sapiens	217-221
31128065-0	2019	TP53 Gene 72 Arg/Pro (rs1042522) Single Nucleotide Polymorphism Contribute to Increase the Risk of B-Chronic Lymphocytic Leukemia in the Sudanese Population Objective: This study aimed at exploring the association of TP53 72Arg/Pro polymorphism and Risk of ChronicLymphocytic Leukemia and to assess the correlation between TP53 72Arg/Pro polymorphism and clinical parameter,hematological profile and some biological prognostic markers among Sudanese patients with chronic lymphocyticleukemia.	Arginine	13-16	tumor protein p53	Homo sapiens	217-221
31286103-9	2019	On follow-up, GH deficiency due to GHRH resistance was suspected and confirmed by clonidine and arginine stimulation tests.	Arginine	96-104	growth hormone releasing hormone	Homo sapiens	35-39
30922994-2	2019	In activated microglia, l-arginine is metabolized competitively by inducible nitric oxide synthase (iNOS) and arginase (Arg), which then synthesize NO or polyamines, respectively.	Arginine	24-34	nitric oxide synthase 2, inducible	Mus musculus	100-104
30922994-9	2019	These findings indicate that Sema4D regulates microglial proliferation at least in part by regulating the competitive balance of l-arginine metabolism.	Arginine	129-139	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	Mus musculus	29-35
30722038-5	2019	Cancer-associated arginine mutations in the WD40 domain (R465H, R479Q and R505C) abolish both FBXW7 interaction with PAR and recruitment to DNA damage sites, causing inhibition of XRCC4 polyubiquitination and NHEJ.	Arginine	18-26	F-box and WD repeat domain containing 7	Homo sapiens	94-99
31190807-0	2019	NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells.	Arginine	30-38	NLR family pyrin domain containing 3	Homo sapiens	0-5
31223455-0	2019	Modifications at Arg and Ile Give Neurotensin(8-13) Derivatives with High Stability and Retained NTS1 Receptor Affinity.	Arginine	17-20	neurotensin	Homo sapiens	97-101
30928100-2	2019	Other in vivo physiological roles have been established for this vertebrate enzyme, such as the processing of Arg-extended forms of human insulin and cholecystokinin 9 and the degradation of viral epitopes in the cytoplasm.	Arginine	110-113	insulin	Homo sapiens	138-167
30743172-3	2019	All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine.	Arginine	27-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70
30753862-0	2019	Histidine and arginine modulate intestinal cell restitution via transforming growth factor-beta1.	Arginine	14-22	transforming growth factor, beta 1	Rattus norvegicus	64-96
30753862-10	2019	Supplementation of 10 microM histidine to DeltaHis or 50 microM arginine to DeltaArg recovered the decreases in both cell restitution and TGF-beta1 extracellular concentration.	Arginine	64-72	transforming growth factor, beta 1	Rattus norvegicus	138-147
30753862-13	2019	The present findings suggested that deletion of histidine or arginine led to a decrease in IEC restitution through a decrease in TGF-beta1.	Arginine	61-69	transforming growth factor, beta 1	Rattus norvegicus	129-138
30929300-3	2019	Here, we constructed two Solo mutants (L14R/L17R and L49R/L52R) with leucine-to-arginine replacements in the N-terminal conserved region (which we termed the Solo domain) and analyzed their K18-binding activities.	Arginine	80-88	Rho guanine nucleotide exchange factor 40	Homo sapiens	25-29
30916578-9	2019	l-arginine showed anti-inflammatory effect through the reduction of liver expression of iNOS, TNF-alpha, and NF-kappabeta, which were ameliorated to significant levels.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	88-92
30916578-9	2019	l-arginine showed anti-inflammatory effect through the reduction of liver expression of iNOS, TNF-alpha, and NF-kappabeta, which were ameliorated to significant levels.	Arginine	0-10	tumor necrosis factor	Rattus norvegicus	94-103
30938419-10	2019	Remarkably, expression of UPF1, a core gene in the NMD pathway, efficiently blocked neurotoxicity caused by arginine-rich dipeptide repeats in both cellular and Drosophila models.	Arginine	108-116	Upf1 RNA helicase	Drosophila melanogaster	26-30
30957988-2	2019	Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of arginines on histone and non-histone proteins, has recently emerged as a putative target for cancer therapy.	Arginine	91-100	protein arginine methyltransferase 5	Homo sapiens	0-36
30957988-2	2019	Protein arginine methyltransferase 5 (PRMT5), an enzyme which catalyzes the methylation of arginines on histone and non-histone proteins, has recently emerged as a putative target for cancer therapy.	Arginine	91-100	protein arginine methyltransferase 5	Homo sapiens	38-43
30929300-3	2019	Here, we constructed two Solo mutants (L14R/L17R and L49R/L52R) with leucine-to-arginine replacements in the N-terminal conserved region (which we termed the Solo domain) and analyzed their K18-binding activities.	Arginine	80-88	Rho guanine nucleotide exchange factor 40	Homo sapiens	158-162
30954674-1	2019	We have previously reported cognitive impairments in both young and old mice, particularly in female mice expressing mouse Arg-61 apoE, with a point mutation to mimic the domain interaction feature of human apoE4, as compared to the wildtype mouse (C57BL/6J) apoE.	Arginine	123-126	apolipoprotein E	Mus musculus	130-134
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Arginine	188-196	vascular endothelial growth factor A	Homo sapiens	17-51
30392062-1	2019	The protein arginine methyltransferase 5 (PRMT5) and its catalytic partner methylosome protein MEP50 (WDR77) catalyse the mono- and symmetric di-methylation of selective arginines in various histones and non-histone target proteins.	Arginine	170-179	protein arginine methyltransferase 5	Homo sapiens	4-40
30392062-1	2019	The protein arginine methyltransferase 5 (PRMT5) and its catalytic partner methylosome protein MEP50 (WDR77) catalyse the mono- and symmetric di-methylation of selective arginines in various histones and non-histone target proteins.	Arginine	170-179	protein arginine methyltransferase 5	Homo sapiens	42-47
30896798-6	2019	The increased [Ca2+]c induced by RSV and L-Arg treatments resulted in CaMKII-dependent MLC20 phosphorylation.	Arginine	41-46	myosin light chain 12B	Homo sapiens	87-92
30954674-3	2019	The results of behavioral performance consistently support our previous report that the young female Arg-61 apoE showed cognitive impairment versus C57BL/6J at the same age.	Arginine	101-104	apolipoprotein E	Mus musculus	108-112
30954674-4	2019	The cyto-architectural results showed that volume of the granular cell layer (GCL) was significantly larger in both 5- and 10-month old Arg-61 apoE mice versus C57BL/6J mice.	Arginine	136-139	apolipoprotein E	Mus musculus	143-147
30954674-7	2019	In conclusion, impaired cognitive functions in female Arg-61 apoE mice appear correlated with larger GCL volume and higher calretinin-positive cell number and suggest a compensatory cellular response that may be related to amyloid beta perturbations early in life.	Arginine	54-57	apolipoprotein E	Mus musculus	61-65
31014000-2	2019	It is known that CFTR exit from the ER is mediated by specific retention/sorting signals that include four arginine-framed tripeptide (AFT) retention motifs and a diacidic (DAD) exit code that controls the interaction with the COPII machinery.	Arginine	107-115	CF transmembrane conductance regulator	Homo sapiens	17-21
30651598-2	2019	Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa.	Arginine	124-132	tumor protein p53	Homo sapiens	44-47
31040342-14	2019	BH4, L-arginine, or BH4 plus L-arginine inhibited eNOS monomerization.	Arginine	5-15	nitric oxide synthase 3	Homo sapiens	50-54
31040342-14	2019	BH4, L-arginine, or BH4 plus L-arginine inhibited eNOS monomerization.	Arginine	29-39	nitric oxide synthase 3	Homo sapiens	50-54
31015538-6	2019	L-arginine improved pregnancy-induced insulin resistance and increased maternal L-arginine and L-ornithine plasma concentrations but foal plasma amino acid concentrations were not affected at birth.	Arginine	0-10	insulin	Homo sapiens	38-45
30869672-4	2019	Our results indicated that the IUGR suckling Hu lambs in the Arg or NCG groups were associated with reduced (P &lt; 0.05) plasma diamine oxidase (DAO) and d-lactic acid levels compared with IUGR suckling lambs.	Arginine	61-64	D-amino-acid oxidase	Ovis aries	129-144
30869672-4	2019	Our results indicated that the IUGR suckling Hu lambs in the Arg or NCG groups were associated with reduced (P &lt; 0.05) plasma diamine oxidase (DAO) and d-lactic acid levels compared with IUGR suckling lambs.	Arginine	61-64	D-amino-acid oxidase	Ovis aries	146-149
30869672-8	2019	IUGR suckling Hu lambs in the Arg or NCG group were linked with a lower ratio of pAMPKalpha/tAMPKalpha and protein expression of Sirt1 and PGC1alpha in the ileum relative to those of the IUGR suckling Hu lambs (P &lt; 0.05).	Arginine	30-33	NAD-dependent protein deacetylase sirtuin-1	Ovis aries	129-134
31179409-0	2019	Identification of Specific Lysines and Arginines That Mediate Angiomotin Membrane Association.	Arginine	39-48	angiomotin	Homo sapiens	62-72
30896163-4	2019	( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect.	Arginine	2-5	tumor necrosis factor	Homo sapiens	81-108
30896163-4	2019	( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect.	Arginine	2-5	tumor necrosis factor	Homo sapiens	110-119
30896163-4	2019	( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect.	Arginine	2-5	interleukin 6	Homo sapiens	125-138
30896163-4	2019	( R)-1 efficiently inhibited the lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), while ( S)-1 produced no significant anti-inflammatory effect.	Arginine	2-5	interleukin 6	Homo sapiens	140-144
30796162-7	2019	In summary, our results reveal that the PD-associated substitutions at Arg-1441 of LRRK2 alter monomer-dimer dynamics and thereby trap its GTPase domain in an activated state.	Arginine	71-74	leucine rich repeat kinase 2	Homo sapiens	83-88
30979040-0	2019	L-Arginine Inhibited Inflammatory Response and Oxidative Stress Induced by Lipopolysaccharide via Arginase-1 Signaling in IPEC-J2 Cells.	Arginine	0-10	arginase 1	Sus scrofa	98-108
30979040-7	2019	Furthermore, L-arginine increased the activity of arginase-1 (Arg-1), while Arg-1 inhibitor abolished the protection of arginine against LPS-induced inflammation and oxidative stress.	Arginine	13-23	arginase 1	Sus scrofa	50-60
30979040-7	2019	Furthermore, L-arginine increased the activity of arginase-1 (Arg-1), while Arg-1 inhibitor abolished the protection of arginine against LPS-induced inflammation and oxidative stress.	Arginine	13-23	arginase 1	Sus scrofa	62-67
30979040-7	2019	Furthermore, L-arginine increased the activity of arginase-1 (Arg-1), while Arg-1 inhibitor abolished the protection of arginine against LPS-induced inflammation and oxidative stress.	Arginine	15-23	arginase 1	Sus scrofa	50-60
30979040-7	2019	Furthermore, L-arginine increased the activity of arginase-1 (Arg-1), while Arg-1 inhibitor abolished the protection of arginine against LPS-induced inflammation and oxidative stress.	Arginine	15-23	arginase 1	Sus scrofa	62-67
30979040-8	2019	Taken together, these results suggested that L-arginine exerted its anti-inflammatory and antioxidant effects to protect IPEC-J2 cells from inflammatory response and oxidative stress challenged by LPS at least partly via the Arg-1 signaling pathway.	Arginine	45-55	arginase 1	Sus scrofa	225-230
30829471-6	2019	More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH.	Arginine	128-133	interferon gamma	Homo sapiens	56-72
30685036-0	2019	Pressure assisted partial filling affinity capillary electrophoresis employed for determination of binding constants of human insulin hexamer complexes with serotonin, dopamine, arginine, and phenol.	Arginine	178-186	insulin	Homo sapiens	126-133
30848915-1	2019	In microorganisms and plants, N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step in l-arginine synthesis, the phosphorylation of N-Acetyl-l-glutamate (NAG) to give N-acetyl-l-glutamate-5-phosphate.	Arginine	94-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	139-159
30848915-1	2019	In microorganisms and plants, N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step in l-arginine synthesis, the phosphorylation of N-Acetyl-l-glutamate (NAG) to give N-acetyl-l-glutamate-5-phosphate.	Arginine	94-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	59-62
30848915-1	2019	In microorganisms and plants, N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step in l-arginine synthesis, the phosphorylation of N-Acetyl-l-glutamate (NAG) to give N-acetyl-l-glutamate-5-phosphate.	Arginine	94-104	N-acetyl-alpha-glucosaminidase	Homo sapiens	30-50
30829471-6	2019	More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH.	Arginine	116-126	interferon gamma	Homo sapiens	56-72
30829471-6	2019	More importantly, the probe revealed that NO induced by interferon-gamma (IFN-gamma), lipopolysaccharide (LPS), and l-arginine (l-Arg) could also elicit the augmentation of intracellular GSH.	Arginine	128-133	interferon gamma	Homo sapiens	74-83
30940768-0	2019	Proteomics profiling of arginine methylation defines PRMT5 substrate specificity.	Arginine	24-32	protein arginine methyltransferase 5	Homo sapiens	53-58
30628488-2	2019	In vitro, iNOS-derived NO production has been shown to depend on the uptake of l-arginine by the cationic amino acid transporters (CAT).	Arginine	79-89	nitric oxide synthase 2, inducible	Mus musculus	10-14
30886105-0	2019	PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.	Arginine	5-13	protein arginine methyltransferase 6	Homo sapiens	29-34
30610471-1	2019	L-Arginine is converted by nitric oxide synthase (NOS) to L-citrulline and nitric oxide (NO).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	27-48
30847846-3	2019	These short, linear segments, known as tankyrase-binding motifs (TBMs), contain some highly conserved features: an arginine at position 1, which occupies a predominantly acidic binding site, and a glycine at position 6 that is sandwiched between two aromatic side chains on the surface of the ARC domain.	Arginine	115-123	tankyrase	Homo sapiens	39-48
30940768-7	2019	Through in vitro methylation assays, we validated a set of PRMT5 targets identified by mass spectrometry and provided previously unknown mechanistic insights into the preference of the enzyme to methylate arginine sandwiched between two neighboring glycines (a Gly-Arg-Gly, or "GRG," sequence).	Arginine	205-213	protein arginine methyltransferase 5	Homo sapiens	59-64
31138989-6	2019	Mutagenesis-based structure-activity analysis revealed that positively charged arginine residue at 165 in TTYH1 and 164 in TTYH2 is critical for the formation of the channel-pore.	Arginine	79-87	tweety family member 2	Homo sapiens	123-128
30865893-0	2019	p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.	Arginine	96-104	tumor protein p53	Homo sapiens	0-3
30632491-8	2019	One of the mutations occurred at the 100th position of mature NGF resulting in a change of residue from arginine to tryptophan (R100W).	Arginine	104-112	nerve growth factor	Homo sapiens	62-65
30298626-4	2019	High nutrient diets upregulated (P &lt; 0.05) mRNA expression of arginase I (Arg I), Pro oxidase and spermidine synthetase (SRM) in the fetal placenta, as well as Arg II, SRM and spermine synthetase (SMS) expression in the fetal liver (most pronounced on day 45 of pregnancy).	Arginine	77-80	arginase 1	Sus scrofa	65-75
30996821-2	2019	It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a pterin cofactor.	Arginine	70-80	nitric oxide synthase 2	Homo sapiens	34-45
30923526-11	2019	Therefore, we provided evidence that, in the context of the full length C1q protein, a key contribution to the interaction with both PTX3 and IgM is given by the B chain Arg residues that line the side of the gC1q heterotrimer, with a minor participation of a Lys residue located at the apex of gC1q.	Arginine	170-173	pentraxin 3	Homo sapiens	133-137
30508037-0	2019	Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression.	Arginine	39-47	protein arginine methyltransferase 6	Homo sapiens	53-58
30320908-4	2019	We observed an increase in aspartate and alanine, together with a decrease in arginine levels, on overexpression of NSD3s or Pdp3, suggesting an increase in the rate of glutaminolysis.	Arginine	78-86	Pdp3p	Saccharomyces cerevisiae S288C	125-129
30918657-5	2019	Two missense mutation in the exon region of the caprine CIITA gene resulted in replacement of arginine with cysteine at position 9473550 (R9473550C) and aspartic acid with glutamic acid at position 9473870 (D9473870E).	Arginine	94-102	MHC class II transactivator	Capra hircus	56-61
30865893-6	2019	We also show that increased intracellular arginine levels following glutamine deprivation are dependent on p53.	Arginine	42-50	tumor protein p53	Homo sapiens	107-110
30202013-1	2019	We recently reported that a CB2R agonist, GW405833 (GW), reduced both the ACh-induced Ca2+ oscillations and the L-arginine-induced Ca2+ signal enhancement in mouse pancreatic acinar cells, suggesting that GW-induced inhibition may prevent the pathogenesis of acute pancreatitis.	Arginine	112-122	cannabinoid receptor 2 (macrophage)	Mus musculus	28-32
30590162-8	2019	Surplus arginine significantly reduced IL-8, Cox2 and TNF-alpha transcription in head kidney cells.	Arginine	8-16	interleukin 8	Salmo salar	39-43
30203124-5	2019	METHODS: Fasting glucagon levels as well as glucagon secretion induced by intravenous administration of arginine were measured in hospitalized 83 patients with diabetes mellitus, including 4 with FT1DM, 18 with type 1 diabetes mellitus (T1DM), 40 with type 2 diabetes mellitus (T2DM), 5 with slowly progressive insulin-dependent diabetes mellitus (SPIDDM), and 16 with pancreatic diabetes mellitus (PDM).	Arginine	104-112	glucagon	Homo sapiens	44-52
30203124-6	2019	RESULTS: The area under the curve for serum glucagon levels after arginine infusion in FT1DM patients was significantly smaller than that in T1DM, T2DM, or SPIDDM patients but was similar to that in PDM patients.	Arginine	66-74	glucagon	Homo sapiens	44-52
30844720-3	2019	Nitric oxide synthase (NOS) is an enzyme that converts L-arginine to nitric oxide (NO), which functions to maintain vascular and adipocyte homeostasis.	Arginine	55-65	nitric oxide synthase 2	Homo sapiens	0-21
30573097-3	2019	The results showed significant correlations (p &lt; 0.05) between sediment ARG levels, especially for tetracycline and sulfonamides (e.g., tet(A), tet(D), tet(E), tet(O), sul1, sul2 and int-1) and specific heavy metals (Fe, Mn, Cr, Cu, Zn, among others) in the Lake.	Arginine	75-78	Wnt family member 1	Homo sapiens	186-191
30639019-2	2019	Methionine supplementation improves milk protein, whereas Arg is taken up in excess by mammary cells to produce energy and nonessential AA that can be incorporated into milk protein.	Arginine	58-61	casein beta	Bos taurus	169-181
30639019-11	2019	Greater supply of Met or Arg reversed most of the effects of HS occurring at the mRNA level and upregulated the abundance of HSPA1A.	Arginine	25-28	heat shock 70 kDa protein 1B	Bos taurus	125-131
30590162-8	2019	Surplus arginine significantly reduced IL-8, Cox2 and TNF-alpha transcription in head kidney cells.	Arginine	8-16	tnf-alpha	Salmo salar	54-63
30590162-11	2019	In addition, in head kidney cells, surplus arginine, when cultured together with LPS, increased the transcription of ornithine decarboxylase (ODC) the limiting enzyme of polyamine synthesis.	Arginine	43-51	ornithine decarboxylase	Salmo salar	117-140
30590162-11	2019	In addition, in head kidney cells, surplus arginine, when cultured together with LPS, increased the transcription of ornithine decarboxylase (ODC) the limiting enzyme of polyamine synthesis.	Arginine	43-51	ornithine decarboxylase	Salmo salar	142-145
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	mitogen-activated protein kinase 1	Mus musculus	121-126
30408659-8	2019	According to the canonical correlation analysis between process operation and ARG removal in MBR, sludge retention time (SRT) seemed to be the major factor affecting removal of dominant ARGs and int1.	Arginine	78-81	Wnt family member 1	Homo sapiens	195-199
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	204-210
30461096-8	2019	This approach was applied to Src mutant libraries randomized in the highly conserved HRD motif in the catalytic loop, and revealed that structurally diverse residues can replace the His and Arg residues, while the Asp residue is irreplaceable for catalytic activity.	Arginine	190-193	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-32
30408659-7	2019	The separation coefficient (Ksw) was proposed to represent the contribution of solid separation on ARG removal, subsequent analysis revealed surprisingly strong correlation between Ksw values of dominant ARGs (ermB, sul1 and int1) and their log removal by MBR (R = 0.79-0.96, p &lt; 0.05), while such correlation was much weaker in traditional process (R = 0.33-0.37), indicating solid separation was the major pathway for removal of dominant ARGs and int1.	Arginine	99-102	Wnt family member 1	Homo sapiens	225-229
31069134-6	2019	The modification of arginine to citrulline enhanced binding of the peptides to HLA-DP4 and induced high-frequency CD4 responses in HLA-DP4 transgenic mouse models.	Arginine	20-28	major histocompatibility complex, class II, DR beta 1	Homo sapiens	131-134
31069134-6	2019	The modification of arginine to citrulline enhanced binding of the peptides to HLA-DP4 and induced high-frequency CD4 responses in HLA-DP4 transgenic mouse models.	Arginine	20-28	major histocompatibility complex, class II, DR beta 1	Homo sapiens	79-82
31069134-6	2019	The modification of arginine to citrulline enhanced binding of the peptides to HLA-DP4 and induced high-frequency CD4 responses in HLA-DP4 transgenic mouse models.	Arginine	20-28	transcription factor Dp family member 3	Homo sapiens	135-138
31069134-6	2019	The modification of arginine to citrulline enhanced binding of the peptides to HLA-DP4 and induced high-frequency CD4 responses in HLA-DP4 transgenic mouse models.	Arginine	20-28	transcription factor Dp family member 3	Homo sapiens	83-86
30717826-6	2019	However, Vpu-mediated inhibition of immune activation required an arginine residue in the cytoplasmic domain that is critical for blocking NF-kappaB signaling downstream of tetherin.	Arginine	66-74	nuclear factor kappa B subunit 1	Homo sapiens	139-148
30510081-1	2019	Approximately 8% to 19% of patients with acute myeloid leukemia (AML) have isocitrate dehydrogenase-2 (IDH2) mutations, which occur at active site arginine residues R140 and R172.	Arginine	147-155	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	75-101
30510081-1	2019	Approximately 8% to 19% of patients with acute myeloid leukemia (AML) have isocitrate dehydrogenase-2 (IDH2) mutations, which occur at active site arginine residues R140 and R172.	Arginine	147-155	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	103-107
30736843-4	2019	PRMT5 and PRMT1, which are important members of the PRMT family, catalyze the transfer of methyl groups to the arginine of substrate proteins.	Arginine	111-119	protein arginine methyltransferase 5	Homo sapiens	0-5
30736843-5	2019	PRMT5 can monomethylate or symmetrically dimethylate arginine residues, while PRMT1 can monomethylate or asymmetrically dimethylate arginine residues.	Arginine	53-61	protein arginine methyltransferase 5	Homo sapiens	0-5
30783097-0	2019	Dual regulation of Arabidopsis AGO2 by arginine methylation.	Arginine	39-47	Argonaute family protein	Arabidopsis thaliana	31-35
30783097-4	2019	Arginine methylation has dual functions in AGO2 regulation.	Arginine	0-8	Argonaute family protein	Arabidopsis thaliana	43-47
30783097-5	2019	Methylated arginine residues can promote AGO2 protein degradation and are also bound by Tudor-domain proteins (TSNs), which can degrade AGO2-associated small RNAs (sRNAs).	Arginine	11-19	Argonaute family protein	Arabidopsis thaliana	41-45
30783097-5	2019	Methylated arginine residues can promote AGO2 protein degradation and are also bound by Tudor-domain proteins (TSNs), which can degrade AGO2-associated small RNAs (sRNAs).	Arginine	11-19	Argonaute family protein	Arabidopsis thaliana	136-140
30783097-7	2019	We speculate that reduced PRMT5 expression during infection may lead to reduced arginine methylation of AGO2, resulting in accumulation of both AGO2 and, via reduced interaction with TSNs, accumulation of AGO2-associated sRNAs, to promote plant immunity.	Arginine	80-88	Argonaute family protein	Arabidopsis thaliana	104-108
30783097-7	2019	We speculate that reduced PRMT5 expression during infection may lead to reduced arginine methylation of AGO2, resulting in accumulation of both AGO2 and, via reduced interaction with TSNs, accumulation of AGO2-associated sRNAs, to promote plant immunity.	Arginine	80-88	Argonaute family protein	Arabidopsis thaliana	144-148
30783097-7	2019	We speculate that reduced PRMT5 expression during infection may lead to reduced arginine methylation of AGO2, resulting in accumulation of both AGO2 and, via reduced interaction with TSNs, accumulation of AGO2-associated sRNAs, to promote plant immunity.	Arginine	80-88	Argonaute family protein	Arabidopsis thaliana	144-148
30783097-8	2019	These results reveal that both the arginine methylation writer (PRMT5) and readers (TSNs) can regulate AGO2-mediated RNAi.	Arginine	35-43	Argonaute family protein	Arabidopsis thaliana	103-107
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	131-135
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	catalase	Homo sapiens	187-190
30759380-6	2019	The structure reveals that Dot1L engages the nucleosome acidic patch using a variant arginine anchor and occupies a conformation poised for methylation.	Arginine	85-93	DOT1 like histone lysine methyltransferase	Homo sapiens	27-32
30391783-6	2019	Mechanistic investigations showed that arginine-61 in MKK6 is critical for binding with gossypetin.	Arginine	39-47	mitogen-activated protein kinase kinase 6	Homo sapiens	54-58
30448895-7	2019	Notably, the UTRs of HAstVs contain putative binding sites for the serine/arginine-rich factors SRSF2, SRSF5, SRSF6, SRSF3, and the multifunctional hnRNPE2 protein.	Arginine	74-82	poly(rC) binding protein 2	Homo sapiens	148-155
30146690-5	2019	Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance.	Arginine	79-87	insulin	Homo sapiens	195-202
30684979-0	2019	50 Years Ago in The Journal of Pediatrics: The Effect of Arginine Infusion on Plasma Growth Hormone and Insulin in Children.	Arginine	57-65	insulin	Homo sapiens	104-111
30545920-0	2019	Macrophage-Derived IL1beta and TNFalpha Regulate Arginine Metabolism in Neuroblastoma.	Arginine	49-57	interleukin 1 beta	Homo sapiens	19-26
30545920-0	2019	Macrophage-Derived IL1beta and TNFalpha Regulate Arginine Metabolism in Neuroblastoma.	Arginine	49-57	tumor necrosis factor	Homo sapiens	31-39
30289978-1	2019	Protein arginine methyltransferase 5 (PRMT5) is the main enzyme responsible for the symmetrical dimethylation of arginine residues on target proteins in both the cytoplasm and the nucleus.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
30710016-10	2019	Mutational studies suggest that allosteric modulation requires a direct interaction between the carboxyl group of allosteric effectors and Arg-120 of Eallo; however, structural studies show some allosterically active FAs positioned in COX-2 in a conformation lacking an interaction with Arg-120.	Arginine	287-290	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-240
30307373-2	2019	This acts as a prelude to the rewarding collaborative studies in the Gait and Wood research groups aimed toward the enhanced delivery of charge neutral ON drugs and the development of a series of Arg-rich cell-penetrating peptides called Pip (peptide nucleic acid/phosphorodiamidate morpholino oligonucleotide [PNA/PMO] internalization peptides) as conjugates of such ONs.	Arginine	196-199	prolactin induced protein	Homo sapiens	238-241
30678118-6	2019	Permanent GHD was defined as a GH peak of &lt;19 ng/mL after administration of growth hormone-releasing hormone (GHRH) + arginine as a provocative test.	Arginine	121-129	growth hormone 1	Homo sapiens	10-12
30598326-6	2019	The apoE variants relate to different amino acids at positions 112 and 158: cysteine in both for apoE2, arginine at both sites for apoE4, and respectively cysteine and arginine for apoE3 that is viewed as the wild type.	Arginine	104-112	apolipoprotein E	Homo sapiens	4-8
30598326-6	2019	The apoE variants relate to different amino acids at positions 112 and 158: cysteine in both for apoE2, arginine at both sites for apoE4, and respectively cysteine and arginine for apoE3 that is viewed as the wild type.	Arginine	104-112	apolipoprotein E	Homo sapiens	131-136
30598326-6	2019	The apoE variants relate to different amino acids at positions 112 and 158: cysteine in both for apoE2, arginine at both sites for apoE4, and respectively cysteine and arginine for apoE3 that is viewed as the wild type.	Arginine	168-176	apolipoprotein E	Homo sapiens	4-8
30598326-6	2019	The apoE variants relate to different amino acids at positions 112 and 158: cysteine in both for apoE2, arginine at both sites for apoE4, and respectively cysteine and arginine for apoE3 that is viewed as the wild type.	Arginine	168-176	apolipoprotein E	Homo sapiens	181-186
30445466-6	2019	Depletion of RNF8 or expression of NONO with lysine to arginine substitutions at positions 279, 290 and 295 prolonged CHK1 phosphorylation over an extended period of time.	Arginine	55-63	checkpoint kinase 1	Homo sapiens	118-122
30621047-5	2019	The resulting vascular subnetwork demonstrates that ellagic acid, caffeic acid, protocatechuic acid, cryptotanshinone, tanshinone I, and tanshinone IIA are linked to NOS3, ARG2, and EDN1 for vascular dilation, implicated with arginine/proline metabolism.	Arginine	226-234	nitric oxide synthase 3	Homo sapiens	166-170
30834358-6	2019	The main outcome measure was maximal insulin secretion quantified after arginine stimulation (AinsRmax).	Arginine	72-80	insulin	Homo sapiens	37-44
30655613-5	2019	The Arg variant of TP53 is more efficient at inducing apoptosis, whereas the Pro variant is a more potent inductor of cell cycle arrest and DNA repair.	Arginine	4-7	tumor protein p53	Homo sapiens	19-23
30723500-10	2019	In addition, arginine supplementation associated with aerobic exercise promoted a decrease in interleukin-6 (IL-6) and interleukin-8 (IL-8) serum levels when compared to the fructose group, demonstrating an anti-inflammatory effect.	Arginine	13-21	interleukin 6	Rattus norvegicus	94-107
30723500-10	2019	In addition, arginine supplementation associated with aerobic exercise promoted a decrease in interleukin-6 (IL-6) and interleukin-8 (IL-8) serum levels when compared to the fructose group, demonstrating an anti-inflammatory effect.	Arginine	13-21	interleukin 6	Rattus norvegicus	109-113
30557648-6	2019	The relative bioavailability of insulin co-administered intranasally using PTD4, 16 mg/mL glycerin and 100 mM ArgHCl was 58% and that using PTD4, 1 w/v% sucrose, and 25 mM ArgHCl was 53% of the bioavailability obtained via the subcutaneous route.	Arginine	110-116	insulin	Homo sapiens	32-39
30557648-6	2019	The relative bioavailability of insulin co-administered intranasally using PTD4, 16 mg/mL glycerin and 100 mM ArgHCl was 58% and that using PTD4, 1 w/v% sucrose, and 25 mM ArgHCl was 53% of the bioavailability obtained via the subcutaneous route.	Arginine	172-178	insulin	Homo sapiens	32-39
30617637-2	2019	For the effective transfection of p11 gene intracellularly, two cationic lipids based on phospholipid DOPE conjugated to basic amino acids histidine and arginine were synthesised, used for liposome formulation and evaluated for their ability as gene delivery vectors.	Arginine	153-161	S100 calcium binding protein A10	Homo sapiens	34-37
30621047-5	2019	The resulting vascular subnetwork demonstrates that ellagic acid, caffeic acid, protocatechuic acid, cryptotanshinone, tanshinone I, and tanshinone IIA are linked to NOS3, ARG2, and EDN1 for vascular dilation, implicated with arginine/proline metabolism.	Arginine	226-234	endothelin 1	Homo sapiens	182-186
30472187-2	2019	Here, we identify a new modification at the CTD, the deimination of arginine and its conversion to citrulline by peptidyl arginine deiminase 2 (PADI2), an enzyme that has been associated with several diseases, including cancer.	Arginine	68-76	CTD	Homo sapiens	44-47
30391748-6	2019	MGO (100 microM) inhibited IFN-gamma and LPS-stimulated iNOS expression through inhibiting Akt phosphorylation and inhibition of iNOS expression was prevented by L-arginine (100 microM) co-treatment.	Arginine	162-172	nitric oxide synthase 2	Rattus norvegicus	56-60
30391748-6	2019	MGO (100 microM) inhibited IFN-gamma and LPS-stimulated iNOS expression through inhibiting Akt phosphorylation and inhibition of iNOS expression was prevented by L-arginine (100 microM) co-treatment.	Arginine	162-172	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
30391748-6	2019	MGO (100 microM) inhibited IFN-gamma and LPS-stimulated iNOS expression through inhibiting Akt phosphorylation and inhibition of iNOS expression was prevented by L-arginine (100 microM) co-treatment.	Arginine	162-172	nitric oxide synthase 2	Rattus norvegicus	129-133
30462524-3	2019	Compared with WT controls, GIP receptor KO mice had normal glucagon responses to oral protein and intravenous arginine, except for an enhanced 1-min response to arginine, whereas glucagon levels after oral protein and intravenous arginine were enhanced in GLP-1 receptor KO mice.	Arginine	110-118	gastric inhibitory polypeptide	Mus musculus	27-30
30462524-3	2019	Compared with WT controls, GIP receptor KO mice had normal glucagon responses to oral protein and intravenous arginine, except for an enhanced 1-min response to arginine, whereas glucagon levels after oral protein and intravenous arginine were enhanced in GLP-1 receptor KO mice.	Arginine	161-169	gastric inhibitory polypeptide	Mus musculus	27-30
30462524-3	2019	Compared with WT controls, GIP receptor KO mice had normal glucagon responses to oral protein and intravenous arginine, except for an enhanced 1-min response to arginine, whereas glucagon levels after oral protein and intravenous arginine were enhanced in GLP-1 receptor KO mice.	Arginine	161-169	gastric inhibitory polypeptide	Mus musculus	27-30
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Arginine	137-140	C-X-C motif chemokine ligand 14	Homo sapiens	17-23
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Arginine	137-140	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Arginine	137-140	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Arginine	137-140	C-X-C motif chemokine ligand 14	Homo sapiens	37-43
30321592-0	2019	Arginine 313 of the putative 8th helix mediates Galphaq/14 coupling of human CC chemokine receptors CCR2a and CCR2b.	Arginine	0-8	C-C motif chemokine receptor 2	Homo sapiens	100-105
30321592-0	2019	Arginine 313 of the putative 8th helix mediates Galphaq/14 coupling of human CC chemokine receptors CCR2a and CCR2b.	Arginine	0-8	C-C motif chemokine receptor 2	Homo sapiens	110-115
30321592-5	2019	Interestingly, the CCR2 receptor isoforms are identical up to arginine 313 (R313) that is part of the putative 8th helix in CCR2 receptors, and the 8th helix has been implicated in the interaction of rhodopsin-like G protein-coupled receptors with Galphaq.	Arginine	62-70	C-C motif chemokine receptor 2	Homo sapiens	19-23
30321592-5	2019	Interestingly, the CCR2 receptor isoforms are identical up to arginine 313 (R313) that is part of the putative 8th helix in CCR2 receptors, and the 8th helix has been implicated in the interaction of rhodopsin-like G protein-coupled receptors with Galphaq.	Arginine	62-70	C-C motif chemokine receptor 2	Homo sapiens	124-128
30321592-5	2019	Interestingly, the CCR2 receptor isoforms are identical up to arginine 313 (R313) that is part of the putative 8th helix in CCR2 receptors, and the 8th helix has been implicated in the interaction of rhodopsin-like G protein-coupled receptors with Galphaq.	Arginine	62-70	rhodopsin	Homo sapiens	200-209
31298161-10	2019	The present review summarizes the role of NRF-2 mediated antioxidant response on the synergistic antitumor effect of L-Arginine and 5-FU in BAC.	Arginine	117-127	NFE2 like bZIP transcription factor 2	Homo sapiens	42-47
28990530-10	2019	When applied to SS-scrambled IGF-1 oligomers, both pH and arginine gradient exhibited an efficient separation of the oligomers.	Arginine	58-66	insulin like growth factor 1	Homo sapiens	29-34
31560593-1	2019	Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit.	Arginine	35-43	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
30377712-15	2019	During OGTT, L-arginine lowered plasma glucose concentrations (AUC0-2 h - 9%, p &lt; 0.01), insulin excursion (AUC0-2 h - 26%, p &lt; 0.05) and peak insulin concentrations (-26%, p &lt; 0.05) in Europid but not South Asian men.	Arginine	13-23	insulin	Homo sapiens	92-99
30377712-15	2019	During OGTT, L-arginine lowered plasma glucose concentrations (AUC0-2 h - 9%, p &lt; 0.01), insulin excursion (AUC0-2 h - 26%, p &lt; 0.05) and peak insulin concentrations (-26%, p &lt; 0.05) in Europid but not South Asian men.	Arginine	13-23	insulin	Homo sapiens	149-156
30467244-9	2019	CONCLUSIONS: The TP53 codon 72 Arg allele and XRCC1 codon 399 Gln allele are likely to have a protective effect against lung adenocarcinoma, especially in individuals older than 50 years of age.	Arginine	31-34	tumor protein p53	Homo sapiens	17-21
31298161-0	2019	Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF-2) Mediated Antioxidant Response on the Synergistic Antitumor Effect of L-Arginine and 5-Fluro Uracil (5FU) in Breast Adenocarcinoma.	Arginine	129-139	NFE2 like bZIP transcription factor 2	Homo sapiens	8-51
31298161-0	2019	Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF-2) Mediated Antioxidant Response on the Synergistic Antitumor Effect of L-Arginine and 5-Fluro Uracil (5FU) in Breast Adenocarcinoma.	Arginine	129-139	NFE2 like bZIP transcription factor 2	Homo sapiens	53-58
31560593-1	2019	Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit.	Arginine	35-38	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
31560593-5	2019	Results: The percentage remineralization of the 2% Arg-NaF and 1100-ppm NaF groups was significantly higher than the 600-ppm NaF group (p<0.001).	Arginine	51-54	C-X-C motif chemokine ligand 8	Homo sapiens	55-58
31560593-7	2019	The EFU, Ca/P ratio, PO43- content of the 2% Arg-NaF group were significantly higher than the 600-ppm NaF group (p<0.01); while no significant difference was found between the 2% Arg-NaF and 1100-ppm NaF groups.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	49-52
31560593-8	2019	Conclusion: Within the limitations of the present study, incorporation of 2% arginine in 600-ppm NaF child formula dentifrice enhanced the remineralization potential of artificial enamel caries, to a level comparable to 1100-ppm NaF adult formula dentifrice.	Arginine	77-85	C-X-C motif chemokine ligand 8	Homo sapiens	97-100
30785340-9	2019	However, women in the SPS+/PE + group had a significantly lower Arg/ADMA ratio than those in the other 3 groups (p = .02).	Arginine	64-67	selenophosphate synthetase 1	Homo sapiens	22-25
30523330-1	2019	In this Letter, "released" should have been "regulated" in the sentence starting: "Deletion of Atg5 in the host similarly regulated circulating arginine and suppressed tumorigenesis..." This has been corrected online.	Arginine	144-152	autophagy related 5	Homo sapiens	95-99
30647491-1	2018	Nitric oxide (NO) is generated by a family of enzymes termed NO synthases (NOS) that convert L-arginine to NO and citrulline.	Arginine	93-103	nitric oxide synthase 2	Homo sapiens	61-73
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	4-7	interleukin 1 beta	Homo sapiens	84-88
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	124-134	interleukin 1 beta	Homo sapiens	84-88
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	interleukin 1 beta	Homo sapiens	132-136
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	interleukin 1 beta	Homo sapiens	204-208
30837762-6	2018	In the frontal lobe, L-Arginine significantly increased (p &lt; 0.05)catalase and GSH levels compared to other groups while in the hippocampus, it significantly (p &lt; 0.05) reduced MDA withno change in other parameters.	Arginine	21-31	catalase	Rattus norvegicus	69-77
30512152-6	2018	Genetic analysis showed that g.7476 G&gt;A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His).	Arginine	121-129	fibrinogen gamma chain	Homo sapiens	87-90
30619275-14	2018	Both L-arginine and L-citrulline therapy were also noted to decrease SMAD7 expression and enhance SIRT-1 abundance.	Arginine	5-15	SMAD family member 7	Rattus norvegicus	69-74
30619275-14	2018	Both L-arginine and L-citrulline therapy were also noted to decrease SMAD7 expression and enhance SIRT-1 abundance.	Arginine	5-15	sirtuin 1	Rattus norvegicus	98-104
30607176-8	2018	The genotypic distribution at codon 72 of TP53 in control group was 20%, 62.4% and 16.6% for Arg (wildtype), Arg/Pro (heterozygous) and Pro (homozygous variant) respectively.	Arginine	93-96	tumor protein p53	Homo sapiens	42-46
30607176-8	2018	The genotypic distribution at codon 72 of TP53 in control group was 20%, 62.4% and 16.6% for Arg (wildtype), Arg/Pro (heterozygous) and Pro (homozygous variant) respectively.	Arginine	109-112	tumor protein p53	Homo sapiens	42-46
30607176-10	2018	The absence of Arg at codon 72 of TP53 is relevant with age higher than 40 years and metastasis to other organs.	Arginine	15-18	tumor protein p53	Homo sapiens	34-38
29965771-8	2018	Our results allow us to determine kinetic parameters of l-Arg binding to the ferrous deoxy iNOS protein for the first time and also provide clues regarding the nature of structural differences between the two interconverting species.	Arginine	56-61	nitric oxide synthase 2, inducible	Mus musculus	91-95
30446222-5	2018	Mechanistically, we demonstrated that LINC01138 interacts with PRMT5 to increase arginine methylation and protein stability of SREBP1, promoting lipid desaturation and cell proliferation in ccRCC.	Arginine	81-89	protein arginine methyltransferase 5	Homo sapiens	63-68
30512152-6	2018	Genetic analysis showed that g.7476 G&gt;A heterozygous missense mutation in exon 8 of FGG gene resulted in mutations in arginine at position 275 of fibrinogen gamma D domain to histidine (Arg275His).	Arginine	121-129	fibrinogen beta chain	Homo sapiens	149-159
30522493-16	2018	CONCLUSIONS: It is proposed that haemozoin interacts with L-arginine reducing its availability for iNOS, and thus decreasing nitric oxide production.	Arginine	58-68	nitric oxide synthase 2	Homo sapiens	99-103
30077773-4	2018	METHODS: Using site-directed mutagenesis, the human GAPDH clone was mutated at one of the NAD+-binding sites, (i.e.) arginine (R13) and isoleucine (I14) to glutamine (Q13) and phenylalanine (F14), respectively.	Arginine	117-125	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
30066085-3	2018	Arginine-framed tripeptides (AFTs) are ER retention motifs shown to modulate CFTR retention.	Arginine	0-8	CF transmembrane conductance regulator	Homo sapiens	77-81
30189247-2	2018	PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2s) and arginine 8 on histone 3 (H3R8me2s), arginine 3 on histones 2A and 4 (H2A/H4R3me2s) as well as several non-histone substrates like Sm proteins.	Arginine	50-58	protein arginine methyltransferase 5	Homo sapiens	0-5
30189247-2	2018	PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2s) and arginine 8 on histone 3 (H3R8me2s), arginine 3 on histones 2A and 4 (H2A/H4R3me2s) as well as several non-histone substrates like Sm proteins.	Arginine	76-84	protein arginine methyltransferase 5	Homo sapiens	0-5
30189247-2	2018	PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2s) and arginine 8 on histone 3 (H3R8me2s), arginine 3 on histones 2A and 4 (H2A/H4R3me2s) as well as several non-histone substrates like Sm proteins.	Arginine	76-84	protein arginine methyltransferase 5	Homo sapiens	0-5
29870258-1	2018	PRMT5 is a major enzyme responsible for symmetric dimethylation of arginine residues on both histone and non-histone proteins, regulating many biological pathways in mammalian cells.	Arginine	67-75	protein arginine methyltransferase 5	Homo sapiens	0-5
30309894-3	2018	We previously showed that three mutants based on apoE3 sequence, in which an arginine was substituted by proline, are thermodynamically destabilized and aggregation-prone.	Arginine	77-85	apolipoprotein E	Homo sapiens	49-54
30513637-7	2018	Excessive supply of NO donor l-arginine reversed the alpha-MSH-induced angiogenesis inhibition in vitro and in vivo.	Arginine	29-39	proopiomelanocortin	Homo sapiens	53-62
30500844-5	2018	ARH1 specifically cleaves the ADP-ribose-arginine bond.	Arginine	41-49	ADP-ribosylarginine hydrolase	Mus musculus	0-4
30475879-11	2018	Finally, the high prevalence of ESBL-producing E. coli with transmissible ARG emphasizes the need to establish legal critical values and monitoring guidelines for ARB in irrigation water.	Arginine	74-77	EsbL	Escherichia coli	32-36
30477550-14	2018	Thermal shift analysis of recombinant p.Q188R GALT protein in the presence of arginine did not exhibit a positive effect.	Arginine	78-86	galactose-1-phosphate uridylyltransferase	Homo sapiens	46-50
30305303-4	2018	Inactivating phosphorylation of its NES, arginine methylation of its RG-repeats, and sumoylation redirect separase from the cytosol to DSBs.	Arginine	41-49	extra spindle pole bodies like 1, separase	Homo sapiens	106-114
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	29-37	ADP-ribosyltransferase 1	Mus musculus	60-84
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	29-37	ADP-ribosyltransferase 1	Mus musculus	86-90
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	29-37	ADP-ribosylarginine hydrolase	Mus musculus	161-192
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	29-37	ADP-ribosylarginine hydrolase	Mus musculus	194-198
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosyltransferase 1	Mus musculus	60-84
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosyltransferase 1	Mus musculus	86-90
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosylarginine hydrolase	Mus musculus	161-192
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosylarginine hydrolase	Mus musculus	194-198
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosyltransferase 1	Mus musculus	60-84
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosyltransferase 1	Mus musculus	86-90
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosylarginine hydrolase	Mus musculus	161-192
30413791-11	2018	These findings suggest that cleavage at S2" is carried out by proteases recognizing a single arginine, most likely TMPRSS2 and cathepsin L.	Arginine	93-101	transmembrane serine protease 2	Homo sapiens	115-122
30413791-11	2018	These findings suggest that cleavage at S2" is carried out by proteases recognizing a single arginine, most likely TMPRSS2 and cathepsin L.	Arginine	93-101	cathepsin L	Homo sapiens	127-138
30256050-1	2018	Competitive inhibition of endothelial nitric oxide synthase (eNOS) is the main biological effect of asymmetric dimethylarginine (ADMA), i.e. the methylated derivative of L-arginine.	Arginine	170-180	nitric oxide synthase 3	Homo sapiens	26-59
30746248-2	2018	Protein arginine methyltransferase 5 (PRMT5) is a primary enzyme in charge of symmetric dimethylation (me2s) of arginine residues.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
30230652-4	2018	We find that P. merdae GUS exhibits a distinct tetrameric quaternary structure and that the mL2 motif traces a unique path within the active site, which also includes two arginines distinctive to this GUS.	Arginine	171-180	skull development traits QTL 2	Mus musculus	92-95
30547036-1	2018	RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich region.	Arginine	150-158	RNA binding motif protein 20	Mus musculus	0-5
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Arginine	121-129	RNA binding motif protein 20	Mus musculus	29-34
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Arginine	121-129	RNA binding motif protein 20	Mus musculus	238-243
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Arginine	137-145	RNA binding motif protein 20	Mus musculus	29-34
30547036-5	2018	Considering that most of the RBM20 mutations identified in familial DCM cases were heterozygous missense mutations in an arginine-serine-arginine-serine-proline (RSRSP) stretch whose phosphorylation is crucial for nuclear localization of RBM20, characterization of a knock-in animal model is awaited.	Arginine	137-145	RNA binding motif protein 20	Mus musculus	238-243
30282806-9	2018	Examination of MOG1"s 3D structure revealed that Glu-83 and the loop containing Asp-148, Arg-150, and Ser-151 are spatially proximal, suggesting that these residues form a critical binding site for Nav1.5.	Arginine	89-92	RAN guanine nucleotide release factor	Homo sapiens	15-19
30429362-1	2018	Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) - i.e., transfer of ADP-ribose from NAD to arginine - is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose-arginine bond.	Arginine	135-143	ADP-ribosylarginine hydrolase	Mus musculus	194-198
30257864-1	2018	Protein arginine methyltransferase 5 (PRMT5) is a member of the arginine methyltransferase protein family that critically mediates the symmetric dimethylation of Arg-3 at histone H4 (H4R3me2s) and is involved in many key cellular processes, including hematopoiesis.	Arginine	162-165	protein arginine methyltransferase 5	Homo sapiens	0-36
30257864-1	2018	Protein arginine methyltransferase 5 (PRMT5) is a member of the arginine methyltransferase protein family that critically mediates the symmetric dimethylation of Arg-3 at histone H4 (H4R3me2s) and is involved in many key cellular processes, including hematopoiesis.	Arginine	162-165	protein arginine methyltransferase 5	Homo sapiens	38-43
30257864-4	2018	Biochemical assays revealed that coactivator-associated arginine methyltransferase 1 (CARM1) interacts directly with and methylates PRMT5 at Arg-505 both in vivo and in vitro.	Arginine	141-144	protein arginine methyltransferase 5	Homo sapiens	132-137
30257864-5	2018	Substitutions at Arg-505 significantly reduced PRMT5"s methyltransferase activity, decreased H4R3me2s enrichment at the gamma-globin gene promoter, and increased the expression of the gamma-globin gene in Lys-562 cells.	Arginine	17-20	protein arginine methyltransferase 5	Homo sapiens	47-52
30082494-4	2018	PRMT5 contributes to GC formation and affinity maturation at least in part through its direct interaction with and methylation of BCL6 at arginine 305 (R305), a modification necessary for the full transcriptional repressive effects of BCL6.	Arginine	138-146	protein arginine methyltransferase 5	Homo sapiens	0-5
30153414-0	2018	Can Arginine Inhibit Insulin Aggregation?	Arginine	4-12	insulin	Homo sapiens	21-28
30153414-2	2018	The oligomeric state of the storage form of human insulin in the pancreas, which may be affected by several endogenous components of beta-cell storage granules such as arginine, is not known.	Arginine	168-176	insulin	Homo sapiens	50-57
30153414-3	2018	Here, the effect of arginine on insulin oligomerization is investigated independently by protein crystallography, molecular dynamics simulations, and capillary electrophoresis.	Arginine	20-28	insulin	Homo sapiens	32-39
30153414-6	2018	In contrast, crystallographic data at high/molar ionic strength indicate inhibition of insulin hexamerization by arginine due to its binding at the site relevant for intermolecular contacts, which was also observed in MD simulations.	Arginine	113-121	insulin	Homo sapiens	87-94
30153414-8	2018	The present findings add to a molecular understanding of in vivo insulin oligomerization and storage, with additional implications for insulin stability in arginine-rich injections.	Arginine	156-164	insulin	Homo sapiens	135-142
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 2	Homo sapiens	137-141
29478426-11	2018	In ovo feeding of Arg also enhanced mammalian target of rapamycin, ribosomal protein S6 kinase-1 and eIF4E-bindingprotein-1 messenger RNA expression levels at hatch compared with those of control groups (P&lt;0.05).	Arginine	18-21	mechanistic target of rapamycin kinase	Homo sapiens	36-65
30348823-3	2018	When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry.	Arginine	135-143	interferon gamma	Homo sapiens	117-133
30348823-3	2018	When human islets were exposed to inflammatory stress induced by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma, arginine residue R510 within GRP78 was converted into citrulline, as evidenced by liquid chromatography-tandem mass spectrometry.	Arginine	135-143	heat shock protein family A (Hsp70) member 5	Homo sapiens	164-169
29715549-7	2018	However, in eukaryotes, SEPHS1 contains other amino acids such as Thr, Arg, Gly, or Leu at the catalytic domain, and SEPHS2 contains only a Sec.	Arginine	71-74	selenophosphate synthetase 1	Homo sapiens	24-30
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 2	Homo sapiens	145-149
30011137-1	2018	Copeptin is a glycosylated peptide derived from the cleavage of the precursor of arginine-vasopressin.	Arginine	81-89	arginine vasopressin	Homo sapiens	0-8
30011137-1	2018	Copeptin is a glycosylated peptide derived from the cleavage of the precursor of arginine-vasopressin.	Arginine	81-89	arginine vasopressin	Homo sapiens	90-101
30142362-7	2018	CONCLUSIONS: Our data provide evidence of a substantial different Zn homeostasis regulation between Znt8 Arg-325 and Trp-325 carriers in PBMCs from T2DM patients.	Arginine	105-108	solute carrier family 30 member 10	Homo sapiens	100-104
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	myosin heavy chain, cardiac muscle complex	Mus musculus	101-119
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	myosin heavy chain, cardiac muscle complex	Mus musculus	121-125
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	myosin heavy chain, cardiac muscle complex	Mus musculus	315-319
30236872-3	2018	In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells.	Arginine	19-27	myosin heavy chain, cardiac muscle complex	Mus musculus	78-82
30236872-3	2018	In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells.	Arginine	19-27	myosin heavy chain, cardiac muscle complex	Mus musculus	106-110
30236872-3	2018	In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells.	Arginine	19-27	myosin heavy chain, cardiac muscle complex	Mus musculus	106-110
30236872-3	2018	In C2C12 myotubes, arginine significantly increased the protein level of slow MyHC and the number of slow MyHC-positive cells, as well as significantly decreased the protein level of fast MyHC and the number of fast MyHC-positive cells.	Arginine	19-27	myosin heavy chain, cardiac muscle complex	Mus musculus	106-110
30236872-6	2018	However, inhibition of AMPK activity by compound C significantly attenuated the effects of arginine on slow MyHC and fast MyHC expressions in C2C12 myotubes.	Arginine	91-99	myosin heavy chain, cardiac muscle complex	Mus musculus	108-112
30236872-6	2018	However, inhibition of AMPK activity by compound C significantly attenuated the effects of arginine on slow MyHC and fast MyHC expressions in C2C12 myotubes.	Arginine	91-99	myosin heavy chain, cardiac muscle complex	Mus musculus	122-126
30236872-7	2018	Finally, we showed that inhibition of Sirt1 expression by EX527 attenuated arginine-induced increase in the protein levels of phospho-AMPK and slow MyHC, the mRNA level of nitric oxide synthase (NOS) and the contents of NOS and NO, as well as decrease in fast MyHC protein level.	Arginine	75-83	myosin heavy chain, cardiac muscle complex	Mus musculus	148-152
30236872-7	2018	Finally, we showed that inhibition of Sirt1 expression by EX527 attenuated arginine-induced increase in the protein levels of phospho-AMPK and slow MyHC, the mRNA level of nitric oxide synthase (NOS) and the contents of NOS and NO, as well as decrease in fast MyHC protein level.	Arginine	75-83	myosin heavy chain, cardiac muscle complex	Mus musculus	260-264
29870781-11	2018	In co-treatment of TR-BBB cells with l-arginine, a NO donor, and glutamate, NO levels were increased and expression levels of iNOS mRNA were similar compared to those in cells treated with glutamate alone.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	126-130
30429607-10	2018	Liver-specific deletion of Atg7 produced circulating ARG1, and reduced both serum arginine and tumour growth.	Arginine	82-90	autophagy related 7	Mus musculus	27-31
30358156-0	2018	L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.	Arginine	0-10	peptide YY	Homo sapiens	56-59
30358156-8	2018	RESULTS: At a dose of 17.1 mmol, L-arginine was well tolerated and stimulated the release of plasma GLP-1 (P &lt; 0.05) and PYY (P &lt; 0.001) following an ad libitum meal.	Arginine	33-43	peptide YY	Homo sapiens	124-127
30358156-10	2018	CONCLUSIONS: L-arginine can significantly elevate GLP-1 and PYY in healthy human volunteers in combination with a meal.	Arginine	13-23	peptide YY	Homo sapiens	60-63
30375398-7	2018	Further investigation revealed that PANDAR-reduced cisplatin sensitivity was likely or partly due to the PANDAR-binding protein SFRS2 (arginine/serine-rich 2), a splicing factor with the ability to negative regulate p53 and its phosphorylation at Serine 15 (Ser15).	Arginine	135-143	tumor protein p53	Homo sapiens	216-219
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Arginine	162-172	tumor necrosis factor	Homo sapiens	6-15
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Arginine	162-172	interleukin 6	Homo sapiens	17-21
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Arginine	162-172	interleukin 1 beta	Homo sapiens	23-31
29894789-4	2018	While TNF-alpha, IL-6, IL-1beta, and NF-kappaB mRNA and protein expression were higher in control HOb-OA cells, the combined supplementation with allopurinol and l-arginine substantially reduced their expression in HOb-OA cells by &gt;40%.	Arginine	162-172	nuclear factor kappa B subunit 1	Homo sapiens	37-46
30142362-2	2018	The Arg-325 risk variant shows accelerated zinc (Zn) transport kinetic and reduced glucose-stimulated insulin secretion in pancreatic cells.	Arginine	4-7	insulin	Homo sapiens	102-109
30142362-4	2018	METHODS AND RESULTS: A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044).	Arginine	99-102	solute carrier family 30 member 10	Homo sapiens	94-98
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	21-24	solute carrier family 30 member 1	Homo sapiens	127-131
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	21-24	solute carrier family 30 member 10	Homo sapiens	133-137
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	21-24	solute carrier family 39 member 2	Homo sapiens	139-143
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	25-28	solute carrier family 30 member 1	Homo sapiens	127-131
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	25-28	solute carrier family 30 member 10	Homo sapiens	133-137
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	25-28	solute carrier family 39 member 2	Homo sapiens	139-143
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interleukin 1 beta	Homo sapiens	29-37
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interferon gamma	Homo sapiens	39-48
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	tumor necrosis factor	Homo sapiens	63-72
30185622-3	2018	Protein phosphatase 1 (PP1) regulates the SR proteins by controlling phosphorylation of a C-terminal arginine-serine-rich (RS) domain.	Arginine	101-109	inorganic pyrophosphatase 1	Homo sapiens	0-21
30185622-3	2018	Protein phosphatase 1 (PP1) regulates the SR proteins by controlling phosphorylation of a C-terminal arginine-serine-rich (RS) domain.	Arginine	101-109	inorganic pyrophosphatase 1	Homo sapiens	23-26
30340470-16	2018	CONCLUSIONS: In summary, we described a case of human congenital cataract and microphthalmia caused by a novel mutation in the CRYAA gene, which substituted an arginine at position 12 in the N-terminal region of alphaA-crystallin.	Arginine	160-168	crystallin alpha A	Homo sapiens	127-132
30332648-5	2018	Integrated transcriptome and protein-protein interaction studies revealed an enrichment of genes implicated in RAS signaling and showed that PRMT6 interacted with CRAF on arginine 100, which decreased its RAS binding potential and altered its downstream MEK/ERK signaling.	Arginine	171-179	mitogen-activated protein kinase kinase 7	Homo sapiens	254-257
30332648-5	2018	Integrated transcriptome and protein-protein interaction studies revealed an enrichment of genes implicated in RAS signaling and showed that PRMT6 interacted with CRAF on arginine 100, which decreased its RAS binding potential and altered its downstream MEK/ERK signaling.	Arginine	171-179	mitogen-activated protein kinase 1	Homo sapiens	258-261
30332648-6	2018	Our work describes a critical repressive function for PRMT6 in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100.	Arginine	163-171	mitogen-activated protein kinase kinase 7	Homo sapiens	118-121
30332648-6	2018	Our work describes a critical repressive function for PRMT6 in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100.	Arginine	163-171	mitogen-activated protein kinase 1	Homo sapiens	122-125
30007131-9	2018	Intensity of staining for NPY-containing fibers tended to decrease (P = 0.10) in Res and Res-Arg compared with Con.	Arginine	93-96	pro-neuropeptide Y	Ovis aries	26-29
30142362-8	2018	Moreover, Znt8 Arg-325 risk variant shows an enhanced inflammatory response upon LPS stimulation that might aggravate insulin resistance and the progression of diabetes cardiovascular complications.	Arginine	15-18	solute carrier family 30 member 10	Homo sapiens	10-14
30142362-8	2018	Moreover, Znt8 Arg-325 risk variant shows an enhanced inflammatory response upon LPS stimulation that might aggravate insulin resistance and the progression of diabetes cardiovascular complications.	Arginine	15-18	insulin	Homo sapiens	118-125
30774789-2	2018	Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control.	Arginine	103-111	tumor protein p53	Homo sapiens	32-35
30323285-6	2018	Inhibition of PGK1 results in accumulation of the reactive metabolite methylglyoxal, which selectively modifies KEAP1 to form a methylimidazole crosslink between proximal cysteine and arginine residues (MICA).	Arginine	184-192	kelch like ECH associated protein 1	Homo sapiens	112-117
30091165-5	2018	Furthermore, l-arginine upregulated mRNA expressions of GSH-Px, SOD, and CAT.	Arginine	13-23	catalase	Mus musculus	73-76
30117761-8	2018	At baseline glucose, L-arginine increased total and active GLP-1 and glucagon concentrations in all GT populations (all P &lt; 0.05).	Arginine	21-31	glucagon	Homo sapiens	59-64
30774789-2	2018	Our research was aimed to study p53 protein codon 72 polymorphism, a single base pair change of either arginine (Arg; CGC) or proline (Pro; CCC) that creates 3 distinct genotypes in reticular oral lichen planus (OLP) in comparison to oral SCC which is the most common oral mucosal malignancy as positive control and inflammatory fibrous hyperplasia (IFH) lesion as negative control.	Arginine	113-116	tumor protein p53	Homo sapiens	32-35
30231473-13	2018	Quantum calculations on the Kv1.2 potassium channel VSD show how; the key is the amphoteric nature of the arginine side chain, which allows it to transfer a proton.	Arginine	106-114	potassium voltage-gated channel subfamily A member 2	Homo sapiens	28-33
30081186-5	2018	The levels of fractalkine on day 0 and 7th day, IP-10 on 4th and 7th day, and IFN-gamma on 7th day in ARG was significantly higher than that in NRG.	Arginine	102-105	C-X3-C motif chemokine ligand 1	Homo sapiens	14-25
30081186-5	2018	The levels of fractalkine on day 0 and 7th day, IP-10 on 4th and 7th day, and IFN-gamma on 7th day in ARG was significantly higher than that in NRG.	Arginine	102-105	interferon gamma	Homo sapiens	78-87
30456381-5	2018	We identified the major CARM1-mediated MED12 methylation site as arginine 1899 (R1899), which interacts with the Tudor domain-containing effector molecule, TDRD3.	Arginine	65-73	tudor domain containing 3	Homo sapiens	156-161
29803864-5	2018	The transistors were able to monitor L-arginine in the 10-1000 muM linear range with a LOD of 10 muM, displaying a fast response and a good long-term stability.	Arginine	37-47	latexin	Homo sapiens	63-66
29803864-5	2018	The transistors were able to monitor L-arginine in the 10-1000 muM linear range with a LOD of 10 muM, displaying a fast response and a good long-term stability.	Arginine	37-47	latexin	Homo sapiens	97-100
29987190-5	2018	We found that TDP43247 is degraded primarily by the Arg/N-end rule pathway, whereas degradation of TDP43219 continues in the absence of ATE1.	Arginine	52-55	TAR DNA binding protein	Homo sapiens	14-22
30152697-3	2018	The peptide sequence Arg-Gly-Asp (RGD), which is present in a number of endogenous integrin ligands like fibronectin, vitronectin, and related proteins of the extracellular matrix (ECM), has been extensively used as a targeting vector for therapeutic as well as diagnostic purposes, and cilengitide, a cyclic RGD peptide, has entered clinical trials for the treatment of various cancers.	Arginine	21-24	fibronectin 1	Homo sapiens	105-116
29902553-7	2018	However, RES-alpha-dicarbonyl conjugates oxidized Cys34 and lysine, arginine and/or proline by a nucleophilic attack on SH and epsilon-NH groups in HSA.	Arginine	68-76	albumin	Homo sapiens	148-151
30232003-4	2018	CARM1 methylates GAPDH at arginine 234 (R234), inhibiting its catalytic activity.	Arginine	26-34	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	17-22
29482350-7	2018	Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process.	Arginine	129-132	tumor protein p53	Homo sapiens	13-17
29482350-7	2018	Knowing that TP53 is an antioncogene protein that acts as a tumor suppressor and regulator of apoptosis, the lowest frequency of Arg/Arg genotype observed in these high-risk patients may indicate lower protection from the atherosclerosis process.	Arginine	133-136	tumor protein p53	Homo sapiens	13-17
30175262-8	2018	Compared with the DT group, the DT + Arg and DT + NCG groups manifested improved anti-hydroxyl radical, catalase, and total superoxide dismutase (T-SOD) activities, increased glutathione content (P &lt; 0.05), and decreased malondialdehyde content (P &lt; 0.05).	Arginine	37-40	superoxide dismutase 1	Homo sapiens	124-144
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	superoxide dismutase 1	Homo sapiens	99-119
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	superoxide dismutase 1	Homo sapiens	121-124
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	188-231
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	233-237
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	kelch like ECH associated protein 1	Homo sapiens	240-275
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	kelch like ECH associated protein 1	Homo sapiens	276-282
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	mechanistic target of rapamycin kinase	Homo sapiens	289-318
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	mechanistic target of rapamycin kinase	Homo sapiens	320-324
30088839-0	2018	Sensing of L-Arginine by Gut-Expressed Calcium Sensing Receptor Stimulates Gut Satiety Hormones Cholecystokinin and Glucose-Dependent Insulinotropic Peptide Secretion in Pig Model.	Arginine	11-21	cholecystokinin	Sus scrofa	96-111
30194083-3	2018	IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic enzyme activity resulting in the accumulation of D-2-hydroxyglutarate (2-HG).	Arginine	51-59	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
29574762-4	2018	DC activation by lipopolysaccharide (LPS), CD40L or TLR8 agonist significantly enhanced Arg II expression without affecting Arg I expression.	Arginine	88-91	toll-like receptor 8	Mus musculus	52-56
29574762-6	2018	In addition, Arg I and Arg II were regulated differentially during Th1 and Th17 cell polarization.	Arginine	13-16	negative elongation factor complex member C/D, Th1l	Mus musculus	67-70
29574762-6	2018	In addition, Arg I and Arg II were regulated differentially during Th1 and Th17 cell polarization.	Arginine	23-26	negative elongation factor complex member C/D, Th1l	Mus musculus	67-70
30042193-6	2018	Comparisons of gene expression profiles in kidney tissues at P22 and P30 in PKD and WT mice revealed that arginine metabolism was significantly activated; 204 differentially expressed genes (DEGs), including Arg1, an arginine metabolism-associated gene, were identified in late-stage polycystic kidneys.	Arginine	106-114	dynein cytoplasmic 1 heavy chain 1	Mus musculus	61-64
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	39-49	cholecystokinin	Sus scrofa	84-99
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	39-49	cholecystokinin	Sus scrofa	101-104
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	39-44	cholecystokinin	Sus scrofa	84-99
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	39-44	cholecystokinin	Sus scrofa	101-104
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	51-56	cholecystokinin	Sus scrofa	84-99
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	51-56	cholecystokinin	Sus scrofa	101-104
30088839-6	2018	Our data showed that treatment with 20 and 50 mM l-Arg induced CCK and GIP secretion compared with 0 mM l-Arg.	Arginine	49-54	cholecystokinin	Sus scrofa	63-66
30088839-8	2018	The potency of l-Arg to induce CCK and GIP secretion was enhanced in the presence of extracellular Ca2+ and CaSR agonist cinacalcet.	Arginine	15-20	cholecystokinin	Sus scrofa	31-34
30088839-9	2018	However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC).	Arginine	23-26	cholecystokinin	Sus scrofa	30-33
30088839-10	2018	Taken all together, pig duodenum provides an appropriate model to explore the effects of l-Arg on the secretion of the satiety-related gut hormones CCK and GIP and the role of CaSR in this effect.	Arginine	89-94	cholecystokinin	Sus scrofa	148-151
30088839-12	2018	PRACTICAL APPLICATION: l-Arginine is able to modulate cholecystokinin and glucose-dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.	Arginine	23-33	cholecystokinin	Sus scrofa	54-69
30015927-10	2018	Furthermore, B-cell lymphoma-2 (Bcl-2) mRNA expression was increased in OTA-treated cells when pretreated with CAG, L-Arg, Sil and GA.	Arginine	116-121	BCL2, apoptosis regulator	Gallus gallus	13-30
30184221-1	2018	Background: The endogenous production of arginine relies on the synthesis of citrulline by enteral ornithine transcarbamylase (OTC).	Arginine	41-49	ornithine transcarbamylase	Mus musculus	99-125
30184221-1	2018	Background: The endogenous production of arginine relies on the synthesis of citrulline by enteral ornithine transcarbamylase (OTC).	Arginine	41-49	ornithine transcarbamylase	Mus musculus	127-130
30015927-10	2018	Furthermore, B-cell lymphoma-2 (Bcl-2) mRNA expression was increased in OTA-treated cells when pretreated with CAG, L-Arg, Sil and GA.	Arginine	116-121	BCL2, apoptosis regulator	Gallus gallus	32-37
30054435-5	2018	In the present study, the effects of Pb on the PRMT5 and MEP50 expression and formation of the symmetrically dimethylated arginine (SDMA), the catalytic product of the PRMT5-MEP50 complex were analyzed in vitro after exposing the A549 and MCF-7 cells.	Arginine	122-130	protein arginine methyltransferase 5	Homo sapiens	168-173
30122195-6	2018	In turn, l-Arg mitigated the downregulation and delocalization of adherens junction protein E-cadherin in HS-exposed cells.	Arginine	9-14	cadherin 1	Homo sapiens	92-102
30122195-8	2018	Inhibition of inducible NO synthase by the NO synthase inhibitor l-NG-nitroarginine methyl ester abrogated the effect of l-Arg on preserving intestinal integrity under HS conditions as measured by transepithelial electrical resistance, Lucifer Yellow flux, and E-cadherin expression.	Arginine	121-126	nitric oxide synthase 2	Homo sapiens	14-35
30122195-8	2018	Inhibition of inducible NO synthase by the NO synthase inhibitor l-NG-nitroarginine methyl ester abrogated the effect of l-Arg on preserving intestinal integrity under HS conditions as measured by transepithelial electrical resistance, Lucifer Yellow flux, and E-cadherin expression.	Arginine	121-126	cadherin 1	Homo sapiens	261-271
30040980-9	2018	In addition, PENK- and POMC-KO mice also attenuated the arginine-induced analgesia.	Arginine	56-64	preproenkephalin	Mus musculus	13-17
30054435-3	2018	The protein arginine methyltransferase 5 (PRMT5) and its partner methylosome protein 50 (MEP50) together catalyze the mono- and symmetric dimethylation of arginine residues in many histone and non-histone protein substrates.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	42-47
30256751-11	2018	Serum growth hormone (GH) levels were significantly higher for patients whose total intake was &gt; 80% of planned volume in the HMB/Arg/Gln group.	Arginine	133-136	growth hormone 1	Homo sapiens	6-20
30256751-11	2018	Serum growth hormone (GH) levels were significantly higher for patients whose total intake was &gt; 80% of planned volume in the HMB/Arg/Gln group.	Arginine	133-136	growth hormone 1	Homo sapiens	22-24
30256751-13	2018	The efficacy of HMB/Arg/Gln for increasing serum GH levels needs to be validated in another large-scale randomized controlled trial.	Arginine	20-23	growth hormone 1	Homo sapiens	49-51
30057274-6	2018	Mechanistically, the loss of arginine methylation at R554 of the PDGFRalpha intracellular domain unmasks a Cbl binding site at Y555.	Arginine	29-37	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	65-75
30581610-4	2019	The treatment with Al further stimulated NO production in root cells while root exposure to NO3 -, L-arginine (Arg) or the NO donor S-nitrosoglutathione (GSNO) decreased both Al and lipid peroxide accumulation in both cultivars.	Arginine	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
29907569-0	2018	Arginine methylation of SMAD7 by PRMT1 in TGF-beta-induced epithelial-mesenchymal transition and epithelial stem-cell generation.	Arginine	0-8	SMAD family member 7	Homo sapiens	24-29
29907569-0	2018	Arginine methylation of SMAD7 by PRMT1 in TGF-beta-induced epithelial-mesenchymal transition and epithelial stem-cell generation.	Arginine	0-8	transforming growth factor beta 1	Homo sapiens	42-50
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Arginine	75-78	fibronectin 1	Homo sapiens	0-11
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Arginine	75-78	fibronectin 1	Homo sapiens	13-15
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Arginine	158-161	fibronectin 1	Homo sapiens	0-11
30044634-2	2018	Fibronectin (Fn) holds two peptide sequences that favor cell adhesion: the Arg-Gly-Asp (RGD) loop on the tenth type-III domain (Fn-III10) and the Pro-His-Ser-Arg-Asn (PHSRN) synergy site on the ninth type-III domain (Fn-III9).	Arginine	158-161	fibronectin 1	Homo sapiens	13-15
30065615-3	2018	Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort.	Arginine	26-34	tumor protein p53	Homo sapiens	9-12
30110646-6	2018	Validation of hemopexin (HPX) as a ARTC1-target protein confirmed the functional importance of ARTC1-mediated extracellular arginine ADP-ribosylation at the systems level.	Arginine	124-132	ADP-ribosyltransferase 1	Mus musculus	35-40
30110646-6	2018	Validation of hemopexin (HPX) as a ARTC1-target protein confirmed the functional importance of ARTC1-mediated extracellular arginine ADP-ribosylation at the systems level.	Arginine	124-132	ADP-ribosyltransferase 1	Mus musculus	95-100
29933199-4	2018	CASE: A novel mutation in the EIF2B5 gene was detected in the heterozygous state; c.1688G > A (p. Arg563Gln) mutation in exon 12, accompanied by a previously detected c.806G > A (p. Arg269Gln) mutation in exon 6, leading to substitution of arginine for a glutamine.	Arginine	240-248	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	30-36
29852244-3	2018	We conducted in vitro functional studies to determine if this Leu-to-Arg mutation alters the function of GIRK2 channels.	Arginine	69-72	potassium inwardly rectifying channel subfamily J member 6	Homo sapiens	105-110
30288482-4	2018	Objective: This study was designed to examine associations of TP53 72 Arg&gt;Pro (rs1042522), and MDM2 309 T&gt;G (rs937283) polymorphisms with spermatogenetic failure in Iranian population.	Arginine	70-73	tumor protein p53	Homo sapiens	62-66
29982753-9	2018	GHRH and arginine stimulation performed almost similarly to the ITT; however, in one study GHRH with arginine stimulation had 66% sensitivity and 88% specificity compared with the ITT.	Arginine	101-109	growth hormone releasing hormone	Homo sapiens	91-95
29941497-5	2018	Arginine-stimulated C-peptide and insulin responses were also greater in youth (1.6- and 1.7-fold, respectively; each P &lt; 0.001).	Arginine	0-8	insulin	Homo sapiens	34-41
30047986-5	2018	Although there is a conserved Arg/Lys rich motif in the Hif-3alpha N-terminal region, deletion of this region has minimal effect on Hif-3alpha nuclear localization.	Arginine	30-33	hypoxia inducible factor 3 subunit alpha	Homo sapiens	56-66
30021151-4	2018	Although the prion-like domain is generally considered to mediate aggregation of FUS, we find that arginine residues in the C-terminal low-complexity domain are also required for maturation of FUS in cellular stress granules.	Arginine	99-107	fusilli	Drosophila melanogaster	193-196
29679612-1	2018	Protein arginine methyltransferase 5 (PRMT5) functions as a tumor initiator to regulate several cancer progressions, such as proliferation and apoptosis, by catalyzing the symmetrical dimethylation (me2s) of arginine residues within targeted molecules.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
29950483-0	2018	Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	32-37
29950483-3	2018	Here, we report that the protein arginine methyltransferase 5 (Prmt5) and symmetric dimethylation at histone H4 arginine 3 (H4R3sme2) directly associate with chromatin of Bmp4 to suppress its transcription.	Arginine	33-41	protein arginine methyltransferase 5	Homo sapiens	63-68
29950483-6	2018	Inhibition of BMP signaling by Noggin rescues the lung branching defects of Prmt5 mutant in vitro Taken together, our results identify a novel mechanism through which Prmt5-mediated histone arginine methylation represses canonical BMP signaling to regulate lung branching morphogenesis.	Arginine	190-198	protein arginine methyltransferase 5	Homo sapiens	76-81
29950483-6	2018	Inhibition of BMP signaling by Noggin rescues the lung branching defects of Prmt5 mutant in vitro Taken together, our results identify a novel mechanism through which Prmt5-mediated histone arginine methylation represses canonical BMP signaling to regulate lung branching morphogenesis.	Arginine	190-198	protein arginine methyltransferase 5	Homo sapiens	167-172
30022074-4	2018	This requires p62 to associate via the Tudor protein SMN with proteins, including FUS, that are symmetrically methylated on arginines.	Arginine	124-133	FUS RNA binding protein	Homo sapiens	82-85
30036999-0	2018	The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.	Arginine	16-24	crystallin alpha A	Homo sapiens	117-122
30036999-0	2018	The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.	Arginine	16-24	heat shock protein family B (small) member 6	Homo sapiens	131-136
30036999-0	2018	The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.	Arginine	16-24	heat shock protein family B (small) member 8	Homo sapiens	142-147
30036999-4	2018	Substitution of this arginine with an alanine induced changes in thermal stability and/or intrinsic fluorescence of the related HspB1 and HspB8, but yielded only modest changes in the same biophysical properties of HspB4, HspB5, and HspB6 which together belong to another clade of vertebrate sHsps.	Arginine	21-29	heat shock protein family B (small) member 8	Homo sapiens	138-143
30036999-4	2018	Substitution of this arginine with an alanine induced changes in thermal stability and/or intrinsic fluorescence of the related HspB1 and HspB8, but yielded only modest changes in the same biophysical properties of HspB4, HspB5, and HspB6 which together belong to another clade of vertebrate sHsps.	Arginine	21-29	heat shock protein family B (small) member 6	Homo sapiens	233-238
29746817-0	2018	Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo.	Arginine	0-8	interferon gamma	Homo sapiens	58-74
29746817-5	2018	The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway.	Arginine	26-34	interferon gamma	Homo sapiens	128-137
29746817-0	2018	Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo.	Arginine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	87-96
29746817-5	2018	The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway.	Arginine	26-34	nuclear factor kappa B subunit 1	Homo sapiens	227-236
29746817-7	2018	Furthermore, the investigation of the clinical data also revealed that the plasma or tissue from human breast cancer patients owned lower arginine level and higher IFN-gamma level than that from patients with benign breast disease, showing IFN-gamma may be a potential control target.	Arginine	138-146	interferon gamma	Homo sapiens	240-249
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	signal transducer and activator of transcription 3	Mus musculus	136-141
29746817-8	2018	Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women.	Arginine	30-38	interferon gamma	Homo sapiens	135-144
29746817-8	2018	Our findings demonstrate that arginine supplement could antagonize the malignant transformation of mammary epithelial cells induced by IFN-gamma (nutritionally induced) both in vitro and in vivo, and IFN-gamma was higher in breast cancer women.	Arginine	30-38	interferon gamma	Homo sapiens	200-209
29784880-0	2018	Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	24-51
29775649-3	2018	B1R and B2R are induced by proinflammatory cytokines and their activation by bradykinin (BK: B2R agonist) or des-arg-kallidin (DAKD: B1R agonist), induces NO and PGI2 production which is key for reducing collagen I levels.	Arginine	112-116	bradykinin receptor B1	Homo sapiens	0-11
29775649-3	2018	B1R and B2R are induced by proinflammatory cytokines and their activation by bradykinin (BK: B2R agonist) or des-arg-kallidin (DAKD: B1R agonist), induces NO and PGI2 production which is key for reducing collagen I levels.	Arginine	112-116	bradykinin receptor B1	Homo sapiens	0-3
29784880-0	2018	Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	53-56
29784880-0	2018	Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	113-116
29784880-0	2018	Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.	Arginine	0-8	CREB binding protein	Homo sapiens	140-143
29784880-3	2018	Although post-translational modifications of TLS, such as arginine methylation, are known to regulate TLS"s nucleocytoplasmic shuttling and assembly in stress granules, its interactions with RNAs remain poorly characterized.	Arginine	58-66	FUS RNA binding protein	Homo sapiens	45-48
29784880-3	2018	Although post-translational modifications of TLS, such as arginine methylation, are known to regulate TLS"s nucleocytoplasmic shuttling and assembly in stress granules, its interactions with RNAs remain poorly characterized.	Arginine	58-66	FUS RNA binding protein	Homo sapiens	102-105
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	FUS RNA binding protein	Homo sapiens	85-88
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	FUS RNA binding protein	Homo sapiens	188-191
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	FUS RNA binding protein	Homo sapiens	188-191
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	CREB binding protein	Homo sapiens	275-278
29784880-5	2018	This result indicated that arginine methylation of TLS abrogates both binding to pncRNA and TLS-mediated inhibition of CBP/p300 HAT activities.	Arginine	27-35	FUS RNA binding protein	Homo sapiens	51-54
29784880-5	2018	This result indicated that arginine methylation of TLS abrogates both binding to pncRNA and TLS-mediated inhibition of CBP/p300 HAT activities.	Arginine	27-35	FUS RNA binding protein	Homo sapiens	92-95
29784880-5	2018	This result indicated that arginine methylation of TLS abrogates both binding to pncRNA and TLS-mediated inhibition of CBP/p300 HAT activities.	Arginine	27-35	CREB binding protein	Homo sapiens	119-122
29784880-6	2018	We also report that an arginine residue within the Arg-Gly-Gly domain of TLS, Arg-476, serves as the major determinant for binding to pncRNA.	Arginine	23-31	FUS RNA binding protein	Homo sapiens	73-76
29784880-6	2018	We also report that an arginine residue within the Arg-Gly-Gly domain of TLS, Arg-476, serves as the major determinant for binding to pncRNA.	Arginine	51-54	FUS RNA binding protein	Homo sapiens	73-76
29784880-6	2018	We also report that an arginine residue within the Arg-Gly-Gly domain of TLS, Arg-476, serves as the major determinant for binding to pncRNA.	Arginine	78-81	FUS RNA binding protein	Homo sapiens	73-76
29784880-7	2018	Either methylation or mutation of Arg-476 of TLS significantly decreased pncRNA binding and thereby prevented a pncRNA-induced allosteric alteration in TLS that is required for its interaction with CBP/p300.	Arginine	34-37	FUS RNA binding protein	Homo sapiens	45-48
29784880-7	2018	Either methylation or mutation of Arg-476 of TLS significantly decreased pncRNA binding and thereby prevented a pncRNA-induced allosteric alteration in TLS that is required for its interaction with CBP/p300.	Arginine	34-37	FUS RNA binding protein	Homo sapiens	152-155
29784880-7	2018	Either methylation or mutation of Arg-476 of TLS significantly decreased pncRNA binding and thereby prevented a pncRNA-induced allosteric alteration in TLS that is required for its interaction with CBP/p300.	Arginine	34-37	CREB binding protein	Homo sapiens	198-201
29784880-9	2018	Taken together, we propose the hypothesis that arginine methylation of TLS regulates both TLS-nucleic acid and TLS-protein interactions and thereby participates in transcriptional regulation.	Arginine	47-55	FUS RNA binding protein	Homo sapiens	71-74
29784880-9	2018	Taken together, we propose the hypothesis that arginine methylation of TLS regulates both TLS-nucleic acid and TLS-protein interactions and thereby participates in transcriptional regulation.	Arginine	47-55	FUS RNA binding protein	Homo sapiens	90-93
29784880-9	2018	Taken together, we propose the hypothesis that arginine methylation of TLS regulates both TLS-nucleic acid and TLS-protein interactions and thereby participates in transcriptional regulation.	Arginine	47-55	FUS RNA binding protein	Homo sapiens	90-93
29990354-7	2018	At T2, NF-kappaB p65 activation was positively related with arginine.	Arginine	60-68	nuclear factor kappa B subunit 1	Homo sapiens	7-16
29722926-4	2018	Akin to cytochrome-b5 (cyt-b5 ), Arg 125 on the C-helix of CYP450s is found to be important for effective electron transfer, thus supporting the competitive behavior of redox partners for CYP450s.	Arginine	33-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	59-65
30038627-1	2018	On murine T cells, GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) ADP-ribosylates the P2X7 ion channel at arginine 125 in response to nicotinamide adenine dinucleotide (NAD+) released during cell preparation.	Arginine	109-117	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	89-93
29983416-6	2018	In addition to these interactions, Arg-49 residue of p38 was also found to interact with Glu-456 of TRF2.	Arginine	35-38	mitogen-activated protein kinase 14	Homo sapiens	53-56
29990383-0	2018	Substitutions for arginine at position 780 in triple helical domain of the alpha1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta.	Arginine	18-26	collagen type I alpha 2 chain	Homo sapiens	112-130
29665354-0	2018	PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH.	Arginine	75-83	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	99-104
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Arginine	120-123	FUS RNA binding protein	Homo sapiens	0-3
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Arginine	120-123	FUS RNA binding protein	Homo sapiens	4-7
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Arginine	158-166	FUS RNA binding protein	Homo sapiens	0-3
29800261-3	2018	TLS/FUS binding to G-quadruplex telomere DNA and telomeric repeat-containing RNA depends especially on RGG3, comprising Arg-Gly-Gly repeats with proline- and arginine-rich regions.	Arginine	158-166	FUS RNA binding protein	Homo sapiens	4-7
29800261-7	2018	Our findings suggest that the G-quadruplex-specific binding abilities of TLS/FUS require RGG3 with a beta-spiral structure stabilized by adjacent proline- and arginine-regions.	Arginine	159-167	FUS RNA binding protein	Homo sapiens	73-76
29800261-7	2018	Our findings suggest that the G-quadruplex-specific binding abilities of TLS/FUS require RGG3 with a beta-spiral structure stabilized by adjacent proline- and arginine-regions.	Arginine	159-167	FUS RNA binding protein	Homo sapiens	77-80
29665354-4	2018	Here, we found that protein arginine methyltransferase 1 (PRMT1) mediated arginine methylation of GAPDH in primary bone marrow-derived macrophages in a NO-dependent manner.	Arginine	28-36	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	98-103
29665354-7	2018	Taken together, our results suggest that PRMT1 has a previously unrecognized function to inhibit activation-induced cell death of macrophages through arginine methylation of GAPDH.	Arginine	150-158	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	174-179
29743242-5	2018	Molecular dynamics simulations revealed that the CDK9/CycT1 interface is stabilized by intramolecular hydrogen bonding of pThr-186 by an arginine triad and Glu-96 of CycT1.	Arginine	137-145	cyclin dependent kinase 9	Homo sapiens	49-53
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Arginine	136-139	fibronectin 1	Homo sapiens	157-168
29749478-1	2018	Protein arginine methyltransferase 5 (PRMT5) is a protein that catalyzes transfer of methyl groups to the arginine residues of proteins and is involved in diverse cellular and biological responses.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
29743242-5	2018	Molecular dynamics simulations revealed that the CDK9/CycT1 interface is stabilized by intramolecular hydrogen bonding of pThr-186 by an arginine triad and Glu-96 of CycT1.	Arginine	137-145	cyclin T1	Homo sapiens	54-59
29743242-6	2018	Arginine triad substitutions that disrupted CDK9/CycT1 assembly accumulated Thr-186-dephosphorylated CDK9 associated with the cytoplasmic Hsp90/Cdc37 chaperone.	Arginine	0-8	cyclin dependent kinase 9	Homo sapiens	44-48
29743242-6	2018	Arginine triad substitutions that disrupted CDK9/CycT1 assembly accumulated Thr-186-dephosphorylated CDK9 associated with the cytoplasmic Hsp90/Cdc37 chaperone.	Arginine	0-8	cyclin T1	Homo sapiens	49-54
29743242-6	2018	Arginine triad substitutions that disrupted CDK9/CycT1 assembly accumulated Thr-186-dephosphorylated CDK9 associated with the cytoplasmic Hsp90/Cdc37 chaperone.	Arginine	0-8	cyclin dependent kinase 9	Homo sapiens	101-105
29953499-0	2018	Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-kappaB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.	Arginine	41-44	nuclear factor kappa B subunit 1	Homo sapiens	60-69
29743236-0	2018	IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.	Arginine	5-8	tumor protein p53	Homo sapiens	69-72
29920217-0	2018	Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation.	Arginine	53-61	protein arginine methyltransferase 5	Homo sapiens	38-43
29718323-0	2018	PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.	Arginine	15-23	protein arginine methyltransferase 5	Homo sapiens	0-5
29718323-2	2018	Here we show that the protein arginine methyltransferase PRMT5 enhances the repair of Top1cc by direct binding to TDP1 and arginine dimethylation of TDP1 at residues R361 and R586.	Arginine	30-38	protein arginine methyltransferase 5	Homo sapiens	57-62
29920217-4	2018	DUSP14 is methylated by PRMT5 at arginine 17, 38, and 45 residues.	Arginine	33-41	protein arginine methyltransferase 5	Homo sapiens	24-29
29920217-5	2018	The DUSP14 triple-methylation mutant was impaired in PRMT5-mediated arginine methylation, TRAF2-mediated lysine ubiquitination, and DUSP14 phosphatase activity.	Arginine	68-76	protein arginine methyltransferase 5	Homo sapiens	53-58
29920217-8	2018	Together, these findings reveal a novel regulatory mechanism of DUSP14 by which PRMT5-mediated arginine methylation may sequentially stimulate TRAF2-mediated DUSP14 ubiquitination and phosphatase activity, leading to inhibition of TCR signaling.-Yang, C.-Y., Chiu, L.-L., Chang, C.-C., Chuang, H.-C., Tan, T.-H.	Arginine	95-103	protein arginine methyltransferase 5	Homo sapiens	80-85
29920217-9	2018	Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation.	Arginine	53-61	protein arginine methyltransferase 5	Homo sapiens	38-43
29196973-10	2018	Sequence alignments of the amino acids for beta-III-spectrin indicated that the arginine at 414 is highly conserved among various species and located towards the end of first spectrin repeat domain.	Arginine	80-88	spectrin beta, non-erythrocytic 2	Homo sapiens	43-60
29884816-4	2018	Based on structural differences in the substrate binding pockets to either side of the P1 Arg, we mutated the P2 and P1" residues to Lys.	Arginine	90-93	inorganic pyrophosphatase 1	Homo sapiens	110-120
29804448-6	2018	Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P &lt; 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P &lt; 0.05) and proline stimulated lamin A/C expression ( P &lt; 0.05).	Arginine	38-46	nitric oxide synthase 3	Homo sapiens	92-96
29614254-6	2018	On the other hand, exchange of the aspartic acid for alanine and then arginine resulted in an increasingly greater bias toward protein phosphatase-1 (PP1) relative to MLCP inhibition, an outcome that resulted in increased paracellular permeability for solutes in the size range of therapeutic peptides, but with a significant increase in cytotoxicity.	Arginine	70-78	inorganic pyrophosphatase 1	Homo sapiens	127-148
29614254-6	2018	On the other hand, exchange of the aspartic acid for alanine and then arginine resulted in an increasingly greater bias toward protein phosphatase-1 (PP1) relative to MLCP inhibition, an outcome that resulted in increased paracellular permeability for solutes in the size range of therapeutic peptides, but with a significant increase in cytotoxicity.	Arginine	70-78	inorganic pyrophosphatase 1	Homo sapiens	150-153
29322360-3	2018	In the present study, we have characterized in vitro Arg   Trp mutant of hCTSK and the same mutant of hCTSL.	Arginine	53-56	cathepsin L	Homo sapiens	102-107
29645362-1	2018	As a reader of di-methylated arginine on various proteins, such as histone, RNA polymerase II, PIWI and Fragile X mental retardation protein, the Tudor domain of Tudor domain-containing protein 3 (TDRD3) mediates transcriptional activation in nucleus and formation of stress granules in the cytoplasm.	Arginine	29-37	fragile X messenger ribonucleoprotein 1	Homo sapiens	104-140
29645362-1	2018	As a reader of di-methylated arginine on various proteins, such as histone, RNA polymerase II, PIWI and Fragile X mental retardation protein, the Tudor domain of Tudor domain-containing protein 3 (TDRD3) mediates transcriptional activation in nucleus and formation of stress granules in the cytoplasm.	Arginine	29-37	tudor domain containing 3	Homo sapiens	162-195
29645362-1	2018	As a reader of di-methylated arginine on various proteins, such as histone, RNA polymerase II, PIWI and Fragile X mental retardation protein, the Tudor domain of Tudor domain-containing protein 3 (TDRD3) mediates transcriptional activation in nucleus and formation of stress granules in the cytoplasm.	Arginine	29-37	tudor domain containing 3	Homo sapiens	197-202
29645362-2	2018	Despite the TDRD3 implication in cancer cell proliferation and invasion, warheads to block the di-methylated arginine recognition pocket of the TDRD3 Tudor domain have not yet been uncovered.	Arginine	109-117	tudor domain containing 3	Homo sapiens	12-17
29645362-2	2018	Despite the TDRD3 implication in cancer cell proliferation and invasion, warheads to block the di-methylated arginine recognition pocket of the TDRD3 Tudor domain have not yet been uncovered.	Arginine	109-117	tudor domain containing 3	Homo sapiens	144-149
29755973-4	2018	Work here shows that mutagenesis of two conserved arginine residues in loop D slowed the activation of the AQP1 ion conductance and impaired the sensitivity of the channel to block by AqB011.	Arginine	50-58	aquaporin 1 (Colton blood group)	Homo sapiens	107-111
29772534-1	2018	The three mammalian isoforms of nitric oxide synthase (NOS) produce the signalling molecule nitric oxide (NO) from L-arginine, molecular oxygen, and NADPH.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	32-53
30191154-9	2018	The glucose/insulin ratio was significantly lower at MGT end (p=0.033) only in arg after training.	Arginine	79-82	insulin	Homo sapiens	12-19
29751999-2	2018	Dyrk1b is an arginine-directed serine/threonineprotein kinase that is expressed at elevated levels in many cancers but remains unknown in the pathologies of neuroinflammation.	Arginine	13-21	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	0-6
29714061-3	2018	In addition to reducing high blood pressure in spontaneously hypertensive rats, egg white ovotransferrin-derived antihypertensive IRW (Ile-Arg-Trp) was shown to exert antiproliferative, antioxidant, and anti-inflammatory effects in A7r5 cells (a vascular smooth muscle cell line) against Ang II stimulation, further indicating its potential in retarding vascular remodelling.	Arginine	139-142	angiotensinogen	Rattus norvegicus	288-294
29257879-3	2018	The aim of this study was to explore the potential of replacing the disulfide bridge in chimeric AGRP-melanocortin peptide Tyr-c[Cys-His-d-Phe-Arg-Trp-Asn-Ala-Phe-Cys]-Tyr-NH2 (1) with 1,2,3-triazole moieties.	Arginine	143-146	agouti related neuropeptide	Mus musculus	97-101
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Arginine	31-39	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-148
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Arginine	31-39	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	150-154
29685038-0	2018	Arginine Promotes Slow Myosin Heavy Chain Expression via Akirin2 and the AMP-Activated Protein Kinase Signaling Pathway in Porcine Skeletal Muscle Satellite Cells.	Arginine	0-8	akirin 2	Homo sapiens	57-64
29685038-1	2018	This study aimed to investigate the effect of arginine on the expression of slow myosin heavy chain (MyHC) I and its underlying mechanism in porcine skeletal muscle satellite cells.	Arginine	46-54	myosin heavy chain 6	Homo sapiens	101-105
29685038-2	2018	Our results showed that arginine upregulated the mRNA (1.54 +- 0.08; p &lt; 0.01) and protein (2.01 +- 0.01; p &lt; 0.001) levels of MyHC I.	Arginine	24-32	myosin heavy chain 6	Homo sapiens	133-137
29685038-3	2018	We also showed that arginine upregulated the expression of Akirin2 (1.35 +- 0.1; p &lt; 0.05) and increased the NO content (1.56 +- 0.04; p &lt; 0.001).	Arginine	20-28	akirin 2	Homo sapiens	59-66
29685038-4	2018	Akirin2 siRNA abolished arginine-induced upregulation of MyHC I and the increase of the NO content.	Arginine	24-32	akirin 2	Homo sapiens	0-7
29685038-4	2018	Akirin2 siRNA abolished arginine-induced upregulation of MyHC I and the increase of the NO content.	Arginine	24-32	myosin heavy chain 6	Homo sapiens	57-61
29685038-6	2018	AMPKalpha2 silencing or AMPK inhibitor Compound C abolished arginine-induced upregulation of MyHC I.	Arginine	60-68	myosin heavy chain 6	Homo sapiens	93-97
29685038-7	2018	Our results provide, for the first time, evidence for the involvement of Akirin2 and the AMPK signaling pathway in arginine-induced MyHC I expression in porcine skeletal muscle satellite cells.	Arginine	115-123	akirin 2	Homo sapiens	73-80
29685038-7	2018	Our results provide, for the first time, evidence for the involvement of Akirin2 and the AMPK signaling pathway in arginine-induced MyHC I expression in porcine skeletal muscle satellite cells.	Arginine	115-123	myosin heavy chain 6	Homo sapiens	132-136
29713719-5	2018	The binding interactions between gamma-carboxyl glutamate and the C-terminal and, interestingly, the arginine side chains of OCN and IACs stabilize under-coordinated IACs, thus promoting their growth.	Arginine	101-109	bone gamma-carboxyglutamate protein	Homo sapiens	125-128
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	WD repeat domain 5	Homo sapiens	120-124
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	125-130
29435722-4	2018	The present study was conducted with porcine mammary epithelial cells (PMECs) to test the hypothesis that Arg enhances milk protein synthesis via activation of the mechanistic target of rapamycin (mTOR) cell signaling.	Arginine	106-109	mechanistic target of rapamycin kinase	Homo sapiens	164-195
29435722-4	2018	The present study was conducted with porcine mammary epithelial cells (PMECs) to test the hypothesis that Arg enhances milk protein synthesis via activation of the mechanistic target of rapamycin (mTOR) cell signaling.	Arginine	106-109	mechanistic target of rapamycin kinase	Homo sapiens	197-201
29435722-8	2018	Addition of 50-500 mumol/L Arg to culture medium increased (P &lt; 0.05) the proliferation of PMECs and the synthesis of proteins (including beta-casein and alpha-lactalbumin), while reducing the rates of proteolysis, in a dose-dependent manner.	Arginine	27-30	lactalbumin alpha	Homo sapiens	157-174
29577948-0	2018	l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.	Arginine	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
29577948-4	2018	After 14 days feeding, the mRNA levels and protein expressions of Keap1 and Cul3 were gradually reduced by increasing l-arginine intake, resulting that the nuclear factor Nrf2 was activated.	Arginine	118-128	NFE2 like bZIP transcription factor 2	Rattus norvegicus	171-175
29577948-5	2018	Upon activation of Nrf2, the expressions of antioxidant responsive element (ARE)-dependent genes and proteins (GCLC, GCLM, GS, GR, GST, GPx, CAT, SOD, NQO1, HO-1) were up-regulated by l-arginine feeding, indicating an upward trend in antioxidant capacity uniformly with the increasing consumption of l-arginine.	Arginine	184-194	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-23
29577948-5	2018	Upon activation of Nrf2, the expressions of antioxidant responsive element (ARE)-dependent genes and proteins (GCLC, GCLM, GS, GR, GST, GPx, CAT, SOD, NQO1, HO-1) were up-regulated by l-arginine feeding, indicating an upward trend in antioxidant capacity uniformly with the increasing consumption of l-arginine.	Arginine	300-310	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-23
29577948-6	2018	The present study demonstrates that the supplementation of l-arginine stimulates GSH synthesis and activates Nrf2 pathway, leading to the up-regulation of ARE-driven antioxidant expressions via Nrf2-Keap1 pathway.	Arginine	59-69	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
29577948-6	2018	The present study demonstrates that the supplementation of l-arginine stimulates GSH synthesis and activates Nrf2 pathway, leading to the up-regulation of ARE-driven antioxidant expressions via Nrf2-Keap1 pathway.	Arginine	59-69	NFE2 like bZIP transcription factor 2	Rattus norvegicus	194-198
29605732-1	2018	Bradykinin-potentiating peptides (BPPs - 5a, 7a, 9a, 10c, 11e, and 12b) of Bothrops jararaca (Bj) were described as argininosuccinate synthase (AsS) activators, improving l-arginine availability.	Arginine	171-181	kininogen 1	Homo sapiens	0-10
29550892-7	2018	The presence of a single nucleotide polymorphism causing an amino acid change in a near actin-interacting domain of Arg, in addition to altered lymphocyte activation in the congenic mice upon immunization with myelin antigen, makes Abl2/Arg a candidate gene for EAE.	Arginine	116-119	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	Mus musculus	232-236
29695495-0	2018	Multiple Arginine Residues Are Methylated in Drosophila Mre11 and Required for Survival Following Ionizing Radiation.	Arginine	9-17	meiotic recombination 11	Drosophila melanogaster	56-61
29695495-2	2018	Previous studies have shown that mammalian Mre11 is methylated at multiple arginines in its C-terminal Glycine-Arginine-Rich motif (GAR) by protein arginine methyltransferase PRMT1.	Arginine	75-84	MRE11 homolog, double strand break repair nuclease	Homo sapiens	43-48
29695495-2	2018	Previous studies have shown that mammalian Mre11 is methylated at multiple arginines in its C-terminal Glycine-Arginine-Rich motif (GAR) by protein arginine methyltransferase PRMT1.	Arginine	111-119	MRE11 homolog, double strand break repair nuclease	Homo sapiens	43-48
29695495-3	2018	Here, we found that the Drosophila Mre11 is methylated at arginines 559, 563, 565, and 569 in the GAR motif by DART1, the Drosophila homolog of PRMT1.	Arginine	58-67	meiotic recombination 11	Drosophila melanogaster	35-40
29695495-5	2018	Arginines methylated Mre11 localizes exclusively in the nucleus as soluble nuclear protein or chromatin-binding protein.	Arginine	0-9	meiotic recombination 11	Drosophila melanogaster	21-26
29695495-9	2018	Thus, we provided evidence that arginines in Drosophila Mre11 are methylated by DART1 methytransferase and flies loss of arginine methylation are sensitive to irradiation.	Arginine	32-41	meiotic recombination 11	Drosophila melanogaster	56-61
29695495-9	2018	Thus, we provided evidence that arginines in Drosophila Mre11 are methylated by DART1 methytransferase and flies loss of arginine methylation are sensitive to irradiation.	Arginine	32-40	meiotic recombination 11	Drosophila melanogaster	56-61
29714061-0	2018	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Inhibits Angiotensin II-Stimulated Migration of Vascular Smooth Muscle Cells via Angiotensin Type I Receptor.	Arginine	52-55	angiotensinogen	Rattus norvegicus	70-84
29867908-0	2018	Arginine Catabolic Mobile Elements in Livestock-Associated Methicillin-Resistant Staphylococcal Isolates From Bovine Mastitic Milk in China.	Arginine	0-8	Weaning weight-maternal milk	Bos taurus	126-130
29054638-8	2018	The expression and activity of arginine and lysine methylation enzymes, protein arginine methyltransferase 5 (PRMT5) and Enhancer of Zeste homolog 2 (EZH2), respectively, were also found to be modulated by alpha-endosulfan.	Arginine	31-39	protein arginine methyltransferase 5	Homo sapiens	72-108
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	8-11	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	60-64
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	21-24	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	60-64
28759296-7	2018	Confirming to this suggestion, both L-arg and vit E reduced TNF-alpha and IL-6 levels and consequently decreased bone resorption as indicated by reduced serum CTx level.	Arginine	36-41	tumor necrosis factor	Rattus norvegicus	60-69
28759296-7	2018	Confirming to this suggestion, both L-arg and vit E reduced TNF-alpha and IL-6 levels and consequently decreased bone resorption as indicated by reduced serum CTx level.	Arginine	36-41	interleukin 6	Rattus norvegicus	74-78
29211299-11	2018	Above all, LOX-1+  CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress.	Arginine	112-115	fucosyltransferase 4	Homo sapiens	19-23
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Arginine	88-96	defensin beta 1	Homo sapiens	40-43
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Arginine	88-96	defensin beta 4A	Homo sapiens	58-61
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Arginine	88-96	defensin beta 1	Homo sapiens	100-103
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Arginine	88-96	defensin beta 4A	Homo sapiens	122-125
29430769-7	2018	Moreover, exchange of various surface residues of SPIp for arginine and glutamate/aspartate outside the glutamine donor region influences the efficiency of modification by MTG.	Arginine	59-67	chromogranin A	Homo sapiens	50-54
29410170-2	2018	l-Arginine is the substrate for endothelial NO synthase (eNOS) which is activated by intracellular alkalization, but nothing is known regarding modulation of system y+/CATs and system y+L activity, and eNOS activity by the pHi in HUVECs.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	32-55
29854093-4	2018	L-Arg supplementation increased the activity of inducible nitric oxide synthase (iNOS), the rate of protein synthesis, and the phosphorylation of mTOR (Thr 2446) and p70S6K (Thr 389).	Arginine	0-5	nitric oxide synthase 2, inducible	Mus musculus	48-79
29854093-4	2018	L-Arg supplementation increased the activity of inducible nitric oxide synthase (iNOS), the rate of protein synthesis, and the phosphorylation of mTOR (Thr 2446) and p70S6K (Thr 389).	Arginine	0-5	nitric oxide synthase 2, inducible	Mus musculus	81-85
29897600-5	2018	Here, we present the structure of the RbBP5 beta-propeller domain revealing a distinct, feature rich surface, dominated by clusters of Arginine residues.	Arginine	135-143	RB binding protein 5, histone lysine methyltransferase complex subunit	Homo sapiens	38-43
29641989-3	2018	Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1.	Arginine	165-173	epidermal growth factor receptor	Homo sapiens	94-98
29471495-4	2018	Protein arginine methyltransferase (PRMT) 1, PRMT3 and PRMT6 all methylate TOP3B in vitro at its C-terminal arginine (R) and glycine (G)-rich motif.	Arginine	8-16	protein arginine methyltransferase 3	Homo sapiens	45-50
29471495-4	2018	Protein arginine methyltransferase (PRMT) 1, PRMT3 and PRMT6 all methylate TOP3B in vitro at its C-terminal arginine (R) and glycine (G)-rich motif.	Arginine	8-16	protein arginine methyltransferase 6	Homo sapiens	55-60
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Arginine	244-252	fibrinogen beta chain	Homo sapiens	113-123
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Arginine	244-252	fibrinogen beta chain	Homo sapiens	175-185
29662311-4	2018	Results: Atomic force microscopy-based force spectroscopy measurements showed a significant decrease both on the fibrinogen-erythrocyte binding force and on its frequency for fibrinogen with the D97E mutation, indicating that the corresponding arginine-glycine-aspartate sequence (residues 95-97) is involved in this interaction, and supporting that the fibrinogen receptor on erythrocytes has a beta3 subunit.	Arginine	244-252	fibrinogen beta chain	Homo sapiens	175-185
29688887-11	2018	Three subjects developed hematuria after GH stimulation testing (clonidine/arginine).	Arginine	75-83	growth hormone 1	Homo sapiens	41-43
29677514-0	2018	Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.	Arginine	73-81	FUS RNA binding protein	Homo sapiens	20-23
29677514-4	2018	In FTD-FUS patients, Transportin is aggregated, and post-translational arginine methylation, which regulates the FUS-Transportin interaction, is lost.	Arginine	71-79	FUS RNA binding protein	Homo sapiens	7-10
29677514-5	2018	Here, we show that Transportin and arginine methylation have a crucial function beyond nuclear import-namely to suppress RGG/RG-driven phase separation and stress granule association of FUS.	Arginine	35-43	FUS RNA binding protein	Homo sapiens	186-189
29677514-6	2018	ALS-associated FUS-NLS mutations weaken the chaperone activity of Transportin and loss of FUS arginine methylation, as seen in FTD-FUS, promote phase separation, and stress granule partitioning of FUS.	Arginine	94-102	FUS RNA binding protein	Homo sapiens	15-18
29677514-6	2018	ALS-associated FUS-NLS mutations weaken the chaperone activity of Transportin and loss of FUS arginine methylation, as seen in FTD-FUS, promote phase separation, and stress granule partitioning of FUS.	Arginine	94-102	FUS RNA binding protein	Homo sapiens	90-93
29677514-6	2018	ALS-associated FUS-NLS mutations weaken the chaperone activity of Transportin and loss of FUS arginine methylation, as seen in FTD-FUS, promote phase separation, and stress granule partitioning of FUS.	Arginine	94-102	FUS RNA binding protein	Homo sapiens	90-93
29337275-2	2018	Phosphorylation of a stretch of arginine-serine (RS) dipeptides in the amino-terminal nucleoplasmic domain of LBR regulates the interactions of the receptor with other nuclear proteins, DNA and RNA and thus modulates tethering of heterochromatin to the nuclear envelope.	Arginine	32-40	lamin B receptor	Rattus norvegicus	110-113
29410170-2	2018	l-Arginine is the substrate for endothelial NO synthase (eNOS) which is activated by intracellular alkalization, but nothing is known regarding modulation of system y+/CATs and system y+L activity, and eNOS activity by the pHi in HUVECs.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	57-61
29131380-8	2018	NF-kappaB was identified as a substrate for arginine methylation and interacted with PRMT6 in MES-13 cells.	Arginine	44-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
29430837-4	2018	Vascular endothelial growth factor (VEGF) binds to the b1 domain of NRP1 through interactions between the C-terminal arginine of VEGF and residues in the NRP1-binding site including Tyr297, Tyr353, Asp320, Ser346 and Thr349.	Arginine	117-125	vascular endothelial growth factor A	Homo sapiens	0-34
29430837-4	2018	Vascular endothelial growth factor (VEGF) binds to the b1 domain of NRP1 through interactions between the C-terminal arginine of VEGF and residues in the NRP1-binding site including Tyr297, Tyr353, Asp320, Ser346 and Thr349.	Arginine	117-125	vascular endothelial growth factor A	Homo sapiens	36-40
29430837-4	2018	Vascular endothelial growth factor (VEGF) binds to the b1 domain of NRP1 through interactions between the C-terminal arginine of VEGF and residues in the NRP1-binding site including Tyr297, Tyr353, Asp320, Ser346 and Thr349.	Arginine	117-125	vascular endothelial growth factor A	Homo sapiens	129-133
30279891-4	2018	Although prothrombin abnormality typically shows a bleeding tendency, variations of arginine at position 596 in the gene encoding prothrombin have been reported to conversely cause thrombosis.	Arginine	84-92	coagulation factor II, thrombin	Homo sapiens	130-141
29383875-1	2018	Ring 1 and YY1 binding protein (RYBP) was first identified in 1999, and its structure includes a conserved Npl4 Zinc finger motif at the N-terminus, a central region that is characteristically enriched with arginine and lysine residues and a C-terminal region enriched with serine and threonine amino acids.	Arginine	207-215	RING1 and YY1 binding protein	Homo sapiens	0-30
29383875-1	2018	Ring 1 and YY1 binding protein (RYBP) was first identified in 1999, and its structure includes a conserved Npl4 Zinc finger motif at the N-terminus, a central region that is characteristically enriched with arginine and lysine residues and a C-terminal region enriched with serine and threonine amino acids.	Arginine	207-215	RING1 and YY1 binding protein	Homo sapiens	32-36
29475987-7	2018	Conversely, LL-37 with Arg residues substituted by homoarginine, which cannot be deiminated, elicited full activity of native LL-37 regardless of PAD2 treatment.	Arginine	23-26	cathelicidin antimicrobial peptide	Homo sapiens	12-17
29475987-7	2018	Conversely, LL-37 with Arg residues substituted by homoarginine, which cannot be deiminated, elicited full activity of native LL-37 regardless of PAD2 treatment.	Arginine	23-26	cathelicidin antimicrobial peptide	Homo sapiens	126-131
29261364-1	2018	BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma.	Arginine	38-46	tumor protein p53	Homo sapiens	16-20
29261364-1	2018	BACKGROUND: The TP53 codon 72 Proline-Arginine polymorphism (TP53 P72R) is the most widely studied candidate among those evaluated for a putative association between impaired apoptosis and glaucoma.	Arginine	38-46	tumor protein p53	Homo sapiens	61-65
29261364-2	2018	Considering the earlier findings about enhanced apoptotic potential by the Arg variant of TP53 P72R and the conflicting results about its association with glaucoma, we initiated a hospital-based case-control association study in a north Indian cohort to investigate the association of TP53 P72R with glaucoma.	Arginine	75-78	tumor protein p53	Homo sapiens	90-94
29397169-8	2018	When Arg was infused with nor-NOHA, the activity of total arginase, ornithine decarboxylase, and nitric oxide synthase, and the concentration of casein, protein, and fat in milk did not change compared with the nor-NOHA group, but the milk protein yield, the expression of some Arg transporters (SLC7A5 and SLC7A8), and milk yield increased.	Arginine	5-8	ornithine decarboxylase	Bos taurus	68-91
29397169-8	2018	When Arg was infused with nor-NOHA, the activity of total arginase, ornithine decarboxylase, and nitric oxide synthase, and the concentration of casein, protein, and fat in milk did not change compared with the nor-NOHA group, but the milk protein yield, the expression of some Arg transporters (SLC7A5 and SLC7A8), and milk yield increased.	Arginine	5-8	solute carrier family 7 member 5	Bos taurus	296-302
29429990-9	2018	Mutations in the arginine-/serine repeat elements of the Gli2 PPD involved in phosphorylation and ubiquitinylation blocked the binding to AR.	Arginine	17-25	GLI family zinc finger 2	Homo sapiens	57-61
29636689-0	2018	D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases.	Arginine	2-5	bradykinin receptor B2	Rattus norvegicus	58-69
29636689-0	2018	D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases.	Arginine	18-21	bradykinin receptor B2	Rattus norvegicus	58-69
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Arginine	60-68	tumor protein p53	Homo sapiens	115-118
29568320-3	2018	The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein.	Arginine	28-36	tumor protein p53	Homo sapiens	241-244
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Arginine	60-68	DEAD-box helicase 17	Homo sapiens	133-136
29557783-3	2018	In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele has a weaker p53 activity and function in tumor suppression.	Arginine	60-68	tumor protein p53	Homo sapiens	157-160
29359547-3	2018	Our previous work has shown that inducible nitric oxide synthase (iNOS) films release NO fluxes upon enzymatic conversion of the substrate l-arginine.	Arginine	139-149	nitric oxide synthase 2	Homo sapiens	33-64
29511098-3	2018	Here, we generated and characterized GrnR493X knockin mice, which model the most common human GRN mutation, a premature stop codon at arginine 493 (R493X).	Arginine	134-142	granulin precursor	Homo sapiens	94-97
29616026-4	2018	When SLC7A7/y+LAT1 was silenced in human THP-1 macrophages and A549 airway epithelial cells by means of short interference RNA (siRNA), a significant induction of the expression and release of the inflammatory mediators IL1beta and TNFalpha was observed, no matter the intracellular arginine availability.	Arginine	283-291	GLI family zinc finger 2	Homo sapiens	41-46
29600168-8	2018	This transition was located in the first base pair of codon 367 (GGA&gt;AGA) in exon 3 of MYOC and was predicted to be a missense substitution of glycine to arginine (p.G367R) in myocilin.	Arginine	157-165	myocilin	Homo sapiens	90-94
29600168-8	2018	This transition was located in the first base pair of codon 367 (GGA&gt;AGA) in exon 3 of MYOC and was predicted to be a missense substitution of glycine to arginine (p.G367R) in myocilin.	Arginine	157-165	myocilin	Homo sapiens	179-187
29359547-3	2018	Our previous work has shown that inducible nitric oxide synthase (iNOS) films release NO fluxes upon enzymatic conversion of the substrate l-arginine.	Arginine	139-149	nitric oxide synthase 2	Homo sapiens	66-70
29386226-5	2018	Importantly, this high expression level is sufficient to ascertain whether HypoPP mutant channels are leaky because of missense mutations at arginine residues in S4 segments of the voltage sensor domains.	Arginine	141-149	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	75-81
29545752-1	2018	Protein arginine methyltransferase 5 (PRMT5) is able to regulate gene transcription by catalyzing the symmetrical dimethylation of arginine residue of histone, which plays a key role in tumorigenesis.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
29309642-7	2018	The Grhl1 DNA-binding domain binds duplex DNA containing the consensus recognition element in a dimeric arrangement, supporting parsimonious target-sequence selection through two conserved arginine residues.	Arginine	189-197	grainyhead like transcription factor 1	Homo sapiens	4-9
29023917-13	2018	We examined 25 human HCC specimens and found a strong correlation (R = 0.8; P &lt; 0.01) between arginine methylation levels and Hnf4alpha expression in these specimens, suggesting that the above mechanism is relevant in patients.	Arginine	97-105	hepatocyte nuclear factor 4 alpha	Homo sapiens	129-138
28556616-1	2018	INTRODUCTION: Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with two added excipients (niacinamide and L-arginine) in order to obtain accelerated absorption after subcutaneous dosing.	Arginine	146-156	insulin	Homo sapiens	26-33
28771730-0	2018	In ovo feeding of l-arginine regulates intestinal barrier functions of posthatch broilers by activating the mTOR signaling pathway.	Arginine	18-28	mechanistic target of rapamycin	Gallus gallus	108-112
28771730-5	2018	The IOF of Arg also increased (P &lt; 0.05) the percentage of proliferating cell nuclear antigen positive cells of villus, and the mRNA expressions of mucin-2, claudin-1, zonula occludens-1 and -2 in jejunal mucosa of 21-day-old broilers.	Arginine	11-14	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	151-158
28771730-5	2018	The IOF of Arg also increased (P &lt; 0.05) the percentage of proliferating cell nuclear antigen positive cells of villus, and the mRNA expressions of mucin-2, claudin-1, zonula occludens-1 and -2 in jejunal mucosa of 21-day-old broilers.	Arginine	11-14	claudin 1	Gallus gallus	160-196
28771730-6	2018	Meanwhile, IOF of Arg increased (P &lt; 0.05) the protein abundance of phosphorylated mechanistic target of rapamycin (mTOR), ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E binding protein 1 in jejunal mucosa.	Arginine	18-21	mechanistic target of rapamycin	Gallus gallus	86-117
28771730-6	2018	Meanwhile, IOF of Arg increased (P &lt; 0.05) the protein abundance of phosphorylated mechanistic target of rapamycin (mTOR), ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E binding protein 1 in jejunal mucosa.	Arginine	18-21	mechanistic target of rapamycin	Gallus gallus	119-123
28771730-7	2018	CONCLUSION: The IOF of Arg improved the development and barrier functions of small intestine, which might be associated with activating the mTOR pathway.	Arginine	23-26	mechanistic target of rapamycin	Gallus gallus	140-144
29341046-1	2018	The purpose of the study was to evaluate the relationship between arginine-levodopa-induced growth hormone (GH) secretion and nonalcoholic fatty liver disease (NAFLD) in obese children.	Arginine	66-74	growth hormone 1	Homo sapiens	92-106
29309642-8	2018	We elucidate the molecular basis of a cancer-related mutation in Grhl1 involving one of these arginines, which completely abrogates DNA binding in biochemical assays and transcriptional activation of a reporter gene in a human cell line.	Arginine	94-103	grainyhead like transcription factor 1	Homo sapiens	65-70
29448109-9	2018	Mutation (lysine residues to arginine (R)) analysis showed that in the presence of cycloheximide K479R- and K491R-hGCPII mutants were less ubiquitinylated and degraded, and decrease in the level of GCPII protein by HDAC1 was significantly blocked by K479R mutants.	Arginine	29-37	folate hydrolase 1	Homo sapiens	115-120
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	55-58	cathepsin L	Homo sapiens	111-122
29478970-6	2018	One hour after study drug, blood was sampled and then arginine (30 g IV) was given to stimulate GH.	Arginine	54-62	growth hormone 1	Homo sapiens	96-98
29278321-1	2018	This study investigated the effect of the excipients, including glycine, mannitol, arginine, trehalose, sorbitol, and poloxamer188, on the stability of recombinant human fibroblast growth factor 21(FGF21) during the process of lyophilization and storage.	Arginine	83-91	fibroblast growth factor 21	Homo sapiens	170-197
29298051-1	2018	We present here an integrated nanotechnology/biology strategy for cancer immunotherapy that uses arginine nanoparticles (ArgNPs) to deliver CRISPR-Cas9 gene editing machinery into cells to generate SIRP-alpha knockout macrophages.	Arginine	97-105	signal regulatory protein alpha	Homo sapiens	198-208
29212318-6	2018	For cytochrome C, arginine resulted in a significant decrease and increase in the adsorption and desorption rates, respectively, while guanidine produced a dramatic increase in the desorption rate, with minimal effect on the adsorption rate.	Arginine	18-26	cytochrome c, somatic	Homo sapiens	4-16
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	cathepsin L	Homo sapiens	111-122
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	cathepsin L	Homo sapiens	96-107
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	cathepsin L	Homo sapiens	247-258
29439465-3	2018	Arginine to cysteine substitutions that occur at either the X or Y position within the Gly-X-Y cause different phenotypes like Stickler syndrome and congenital spondyloepiphyseal dysplasia (SEDC).	Arginine	0-8	collagen type II alpha 1 chain	Homo sapiens	190-194
29244490-1	2018	PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins.	Arginine	48-56	protein arginine methyltransferase 3	Homo sapiens	0-5
29401205-8	2018	RESULTS Our results demonstrated that L-Arg significantly activated PKG II and effectively ameliorated xenograft tumor development through inhibiting cancer growth, angiogenesis, and metastasis, which was partially dependent on blocking of epidermal growth factor receptor (EGFR) activity, as well as downstream signaling pathways such as Erk1/2.	Arginine	38-43	epidermal growth factor receptor	Homo sapiens	240-272
29425510-5	2018	Structure-function analyses revealed similar N-C interaction in TRPP2 as well as TRPM8/-V1/-C4 via highly conserved tryptophan and lysine/arginine residues.	Arginine	138-146	polycystin 2, transient receptor potential cation channel	Homo sapiens	64-69
29401205-8	2018	RESULTS Our results demonstrated that L-Arg significantly activated PKG II and effectively ameliorated xenograft tumor development through inhibiting cancer growth, angiogenesis, and metastasis, which was partially dependent on blocking of epidermal growth factor receptor (EGFR) activity, as well as downstream signaling pathways such as Erk1/2.	Arginine	38-43	epidermal growth factor receptor	Homo sapiens	274-278
29401205-8	2018	RESULTS Our results demonstrated that L-Arg significantly activated PKG II and effectively ameliorated xenograft tumor development through inhibiting cancer growth, angiogenesis, and metastasis, which was partially dependent on blocking of epidermal growth factor receptor (EGFR) activity, as well as downstream signaling pathways such as Erk1/2.	Arginine	38-43	mitogen-activated protein kinase 3	Homo sapiens	339-345
29074451-4	2018	METHODS: Pancreatitis was induced in C57BL/6J mice (control) and mice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administration of L-arginine (also in rats), caerulein, bile acid, or an AP-inducing diet.	Arginine	164-174	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	111-124
29074451-15	2018	In particular, the pathway involving enhanced interaction of cyclophilin D with ATP synthase mediates L-arginine-induced pancreatitis, a model of severe AP the pathogenesis of which has remained unknown.	Arginine	102-112	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	61-74
28278764-5	2018	Using circular dichroism (CD) spectroscopy and changing the possible salt-bridging residues to new combinations of Lys, Arg, Glu, and Asp, we found that our most helical improvements came from the Arg-Glu combination, whereas the Lys-Asp was not significantly different from the Lys-Glu of the parent scaffold, PT3.	Arginine	120-123	zinc finger protein 135	Homo sapiens	311-314
28278764-5	2018	Using circular dichroism (CD) spectroscopy and changing the possible salt-bridging residues to new combinations of Lys, Arg, Glu, and Asp, we found that our most helical improvements came from the Arg-Glu combination, whereas the Lys-Asp was not significantly different from the Lys-Glu of the parent scaffold, PT3.	Arginine	197-200	zinc finger protein 135	Homo sapiens	311-314
28278764-6	2018	The marked 310-helical contributions in PT3 were lessened in the Arg-Glu-containing peptide with the beginning of cooperative unfolding seen through a thermal denaturation.	Arginine	65-68	zinc finger protein 135	Homo sapiens	40-43
29208698-0	2018	Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity.	Arginine	0-8	apolipoprotein A1	Homo sapiens	16-34
29208698-3	2018	Our recent crystal structure of Delta(185-243)apoA-I showed the tunnel formed by helices 5/5, with two positively charged residues arginine 123 positioned at the edge of the hydrophobic tunnel.	Arginine	131-139	apolipoprotein A1	Homo sapiens	46-52
29479097-9	2018	CONCLUSIONS: In Pakistani women the association of TP53 gene codon 72 arginine/proline polymorphism was present..	Arginine	70-78	tumor protein p53	Homo sapiens	51-55
29355491-13	2018	Substitution of these lysine residues with arginine eliminated HDAC6 effects.	Arginine	43-51	histone deacetylase 6	Homo sapiens	63-68
29490093-0	2018	Arginine Metabolism Is Altered in Adults with A-beta + Ketosis-Prone Diabetes.	Arginine	0-8	amyloid beta precursor protein	Homo sapiens	46-52
29490093-4	2018	Methods: Kinetics of arginine and related metabolites were measured with stable isotope tracers, and insulin secretory responses to arginine and glucose were determined under euglycemic and hyperglycemic conditions in 6 KPD patients and 6 age-, gender-, and body mass index-matched control participants.	Arginine	132-140	insulin	Homo sapiens	101-108
29490093-8	2018	In both euglycemia and hyperglycemia, the first-phase insulin responses to glucose stimulation were lower in KPD patients (euglycemic insulin AUC 282 +- 108 compared with 926 +- 257 min   muU   mL-1, P = 0.02; hyperglycemic insulin AUC 358 +- 79 compared with 866 +- 292 min   muU   mL-1, P = 0.05), but exogenous arginine restored first-phase insulin secretion in KPD patients to the level of control participants.	Arginine	314-322	insulin	Homo sapiens	54-61
29490093-11	2018	Exogenous arginine administration restores a normal insulin secretory response.	Arginine	10-18	insulin	Homo sapiens	52-59
29594587-4	2018	With increased concentrations of Arg, the ratio of I616/I412 linearly decreases with Arg concentration ranging from 0 to 50 muM and from 50 to 100 muM, respectively.	Arginine	33-36	latexin	Homo sapiens	124-127
29358076-0	2018	Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.	Arginine	120-128	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	20-27
29358076-6	2018	Conversely, arginine methylation reduces hnRNPA2 phase separation, disrupting arginine-mediated contacts.	Arginine	12-20	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	41-48
28649743-7	2018	Prior, l-arginine supplementation attenuates neutrophil infiltration (5622; P&lt;.0001), and also TNF-alpha (506.01; P&lt;.05) and IL-6 (2.51, P&lt;.05) levels.	Arginine	7-17	tumor necrosis factor	Rattus norvegicus	98-107
28649743-7	2018	Prior, l-arginine supplementation attenuates neutrophil infiltration (5622; P&lt;.0001), and also TNF-alpha (506.01; P&lt;.05) and IL-6 (2.51, P&lt;.05) levels.	Arginine	7-17	interleukin 6	Rattus norvegicus	131-135
28649743-9	2018	RE animals displayed increased of atrogin-1 (1.9 fold) and MuRF-1 (3.2 fold) mRNA levels, reversed by l-arg supplementation [atrogin-1 (0.6 fold; P&lt;.001); MuRF-1 (0.8-fold; P&lt;.001)] at 24 hours post-RE.	Arginine	102-107	F-box protein 32	Rattus norvegicus	125-134
29080813-8	2018	RESULTS: Arg inhibited the TLR4 downstream pathway by binding to TLR4 and consequently activated Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway.	Arginine	9-12	toll-like receptor 4	Mus musculus	27-31
29080813-8	2018	RESULTS: Arg inhibited the TLR4 downstream pathway by binding to TLR4 and consequently activated Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway.	Arginine	9-12	toll-like receptor 4	Mus musculus	65-69
29080813-10	2018	Arg activity was absent in liver-specific TLR4 knockout mice and was greatly suppressed in liver with overexpressed TLR4, suggesting that hepatic TLR4 was required and sufficient to induce GH resistance.	Arginine	0-3	toll-like receptor 4	Mus musculus	42-46
29080813-10	2018	Arg activity was absent in liver-specific TLR4 knockout mice and was greatly suppressed in liver with overexpressed TLR4, suggesting that hepatic TLR4 was required and sufficient to induce GH resistance.	Arginine	0-3	toll-like receptor 4	Mus musculus	116-120
29080813-10	2018	Arg activity was absent in liver-specific TLR4 knockout mice and was greatly suppressed in liver with overexpressed TLR4, suggesting that hepatic TLR4 was required and sufficient to induce GH resistance.	Arginine	0-3	toll-like receptor 4	Mus musculus	116-120
29080813-13	2018	CONCLUSIONS: Our results demonstrate a previously unappreciated pathway involving Arg that reverses GH resistance and alleviates malnutrition-induced growth restriction through the inhibition of TLR4-mediated inflammatory pathway.	Arginine	82-85	toll-like receptor 4	Mus musculus	195-199
28044061-9	2018	Overall, our in silico search for post-transcriptional regulators identified miR-495 as a novel regulator of multiple ARGs that have a role in modulating motivation for cocaine.	Arginine	118-122	microRNA 495	Rattus norvegicus	77-84
29594587-4	2018	With increased concentrations of Arg, the ratio of I616/I412 linearly decreases with Arg concentration ranging from 0 to 50 muM and from 50 to 100 muM, respectively.	Arginine	33-36	latexin	Homo sapiens	147-150
29594587-4	2018	With increased concentrations of Arg, the ratio of I616/I412 linearly decreases with Arg concentration ranging from 0 to 50 muM and from 50 to 100 muM, respectively.	Arginine	85-88	latexin	Homo sapiens	124-127
29386660-2	2018	The exploration of FBXW7 mutations in human primary cancer has revealed three mutation hotspots at conserved arginine residues (Arg465, Arg479, and Arg505) in the WD40 domain, which are critical for substrate recognition.	Arginine	109-117	F-box and WD repeat domain containing 7	Homo sapiens	19-24
29594587-4	2018	With increased concentrations of Arg, the ratio of I616/I412 linearly decreases with Arg concentration ranging from 0 to 50 muM and from 50 to 100 muM, respectively.	Arginine	85-88	latexin	Homo sapiens	147-150
29158275-4	2018	We then replaced the noncationic and nonhydrophobic residues with electropositive Arg to increase the antibacterial activity of HD5 derivative that contains a Cys2-4 bond, obtaining another derivative termed HD5d5.	Arginine	82-85	defensin alpha 5	Homo sapiens	128-131
29358647-1	2018	Twin-arginine translocation (Tat) systems transport folded proteins that harbor a conserved arginine pair in their signal peptides.	Arginine	5-13	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	29-32
29976090-8	2018	By forming a complex with PARK7 (and possibly misfolded protein cargoes), R-HSPA5 binds SQSTM1 through its Nt-Arg, facilitating self-polymerization of SQSTM1 and the targeting of SQSTM1-cargo complexes to phagophores.	Arginine	110-113	heat shock protein family A (Hsp70) member 5	Homo sapiens	74-81
29158051-5	2018	Subsequent post-transcriptional modifications, including phosphorylation, ubiquitination, acetylation, deacetylation, arginine methylation and O-GlcNAcylation, activate or inhibit FOXO1.	Arginine	118-126	forkhead box O1	Homo sapiens	180-185
29321566-0	2018	N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-beta(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer"s disease.	Arginine	98-106	amyloid beta precursor protein	Homo sapiens	67-79
29227283-4	2018	Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI.	Arginine	107-115	protein arginine methyltransferase 5	Homo sapiens	10-15
29127889-1	2018	OBJECTIVE: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS).	Arginine	67-77	nitric oxide synthase 2	Homo sapiens	97-108
29351814-10	2018	CONCLUSIONS: Our results demonstrate a novel and unexpected role for SETDB1 in protecting IAPs from TET2-dependent histone arginine demethylation.	Arginine	123-131	SET domain, bifurcated 1	Mus musculus	69-75
29330450-0	2018	C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.	Arginine	17-25	RNA binding motif protein 8A	Homo sapiens	73-76
29330450-0	2018	C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.	Arginine	17-25	RNA binding motif protein 8A	Homo sapiens	78-83
28986316-9	2018	Analysis of the top 5 mutated positions of each gene (210 DNA segments for 42 TS genes) identified that CG nucleotides of the amino acid codons (e.g., Arginine) are most susceptible to mutation, and found a consensus DNA "T/AGC/GAGGA/TG" sequence present in these mutation prone DNA segments.	Arginine	151-159	TSC complex subunit 1	Homo sapiens	78-80
29301528-5	2018	Nitric oxide synthase (NOS) catalyzes the conversion of Arg (high affinity) and hArg (low affinity) to nitric oxide (NO) which is a pleiotropic signaling molecule.	Arginine	56-59	nitric oxide synthase 2	Homo sapiens	0-21
28936587-2	2018	In this study we examined the association of metabolite levels and pairwise metabolite ratios with insulin responses after glucose, glucagon-like peptide-1 (GLP-1) and arginine stimulation.	Arginine	168-176	insulin	Homo sapiens	99-106
28643125-3	2018	Recently, it has been reported that arginine 198/200 in EGFR extracellular domain is methylated by PRMT1 and that the methylation confers resistance to EGFR monoclonal antibody cetuximab in colorectal cancer cells.	Arginine	36-44	epidermal growth factor receptor	Homo sapiens	56-60
28643125-3	2018	Recently, it has been reported that arginine 198/200 in EGFR extracellular domain is methylated by PRMT1 and that the methylation confers resistance to EGFR monoclonal antibody cetuximab in colorectal cancer cells.	Arginine	36-44	epidermal growth factor receptor	Homo sapiens	152-156
30245763-1	2018	NG-hydroxy-L-arginine (NOHA) is a stable intermediate product in the consumption of L-arginine in the urea cycle by nitric oxide synthase (NOS) to produce nitric oxide (NO) and L-citrulline.	Arginine	11-21	nitric oxide synthase 2	Homo sapiens	116-137
29439324-11	2018	Our findings demonstrate that AbetaPP/Abeta alters arginine metabolism and induces a shift of cellular homeostasis that may support the oxidative/nitrosative stress observed in AD.	Arginine	51-59	amyloid beta precursor protein	Homo sapiens	30-35
29887621-3	2018	NO is synthesized by nitric oxide synthase (NOS) during two-step oxidation of l-arginine to l-citrulline.	Arginine	78-88	nitric oxide synthase 2	Homo sapiens	21-42
29202399-2	2018	We and others have previously documented that the uPAR(84-95) sequence, interacts with the formyl peptide receptors (FPR)s, henceforth inducing cell migration of several cell lines, including leukocytes, and the synthetic shorter peptide (Ser88-Arg-Ser-Arg-Tyr92, SRSRY) retains chemotactic activity in vitro and in vivo.	Arginine	245-248	plasminogen activator, urokinase	Homo sapiens	50-54
29143452-4	2018	We designed variants of Hst-5 with its lysine residues substituted with arginine or leucine to evaluate the effect on proteolysis by Saps.	Arginine	72-80	histatin 3	Homo sapiens	24-29
29307398-6	2018	TP53 codon 72 (arginine) exhibits higher rates of apoptosis and leukemia inhibitory factor expression, whereas the C allele (proline) reduces leukemia inhibitory factor expression.	Arginine	15-23	tumor protein p53	Homo sapiens	0-4
30170650-8	2018	As well as, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as liver injury indices, increased in MI-groups and decreased by training and L-arginine.	Arginine	158-168	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	12-38
30170650-8	2018	As well as, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as liver injury indices, increased in MI-groups and decreased by training and L-arginine.	Arginine	158-168	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	40-43
29128891-3	2018	Moreover, protein arginine methyltransferase (PRMT)1-dependent arginine modification of forkhead box other (FoxO)1 protein interferes with Akt-dependent phosphorylation.	Arginine	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	139-142
29077951-6	2018	The plasma glucose and insulin levels were higher in the Arg group than in the non-injected and diluent-injected control groups (P &lt; 0.05).	Arginine	57-60	insulin	Homo sapiens	23-30
30467554-1	2018	Activated mouse macrophages metabolize arginine via NO synthase (NOS2) to produce NO as an antimicrobial effector.	Arginine	39-47	nitric oxide synthase 2, inducible	Mus musculus	65-69
30362913-5	2018	Arginine has an effect on the DNA-binding activity of NF-kappaB, a dominant transcriptional factor in inflammation.	Arginine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	54-63
29683372-1	2018	Chtop binds competitively to the arginine methyltransferases PRMT1 and PRMT5, thereby promoting the asymmetric or symmetric methylation of arginine residues, respectively.	Arginine	33-41	protein arginine methyltransferase 5	Homo sapiens	71-76
28986506-4	2018	Furthermore, methylation of arginines in the RGG domain abolishes the protein-protein interaction and the inhibitory effect of Sbp1 on translation initiation of Pab1 mRNA.	Arginine	28-37	poly(A) binding protein cytoplasmic 1 pseudogene 10	Homo sapiens	161-165
29129203-0	2017	NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.	Arginine	61-69	two pore segment channel 1	Homo sapiens	34-52
29271175-11	2017	The NR1-S1 and NR1-S2 were linked with G (arginine) and T (threonine) amino acid as a combined fragment.	Arginine	42-50	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	4-7
29271175-11	2017	The NR1-S1 and NR1-S2 were linked with G (arginine) and T (threonine) amino acid as a combined fragment.	Arginine	42-50	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	15-18
29259090-9	2017	Together, these findings suggest that SLC6A14 activity plays a role in the modification of the initial stages of airway infection by altering the level of l-arginine in the ASL, which in turn affects the attachment of P. aeruginosaIMPORTANCE CF patients with shared CFTR gene mutations show significant variability in their clinical presentation of infectious lung disease.	Arginine	155-165	CF transmembrane conductance regulator	Homo sapiens	266-270
29312811-0	2017	Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.	Arginine	0-8	epidermal growth factor receptor	Homo sapiens	24-28
29312811-0	2017	Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.	Arginine	0-8	epidermal growth factor receptor	Homo sapiens	80-84
29312811-1	2017	Arginine methylation of the epidermal growth factor receptor (meEGFR) increases the binding affinity of EGFR ligands and is reported to have a role in predicting response to anti-EGFR agents.	Arginine	0-8	epidermal growth factor receptor	Homo sapiens	64-68
29312811-1	2017	Arginine methylation of the epidermal growth factor receptor (meEGFR) increases the binding affinity of EGFR ligands and is reported to have a role in predicting response to anti-EGFR agents.	Arginine	0-8	epidermal growth factor receptor	Homo sapiens	104-108
29951436-0	2017	Association of p53 codon 72 Arg&gt;Pro polymorphism and risk of cancer in Iranian population: A systematic review and meta-analysis.	Arginine	28-31	tumor protein p53	Homo sapiens	15-18
29951436-1	2017	Background: Different studies have investigated the association between p53 codon 72 Arg&gt;Pro polymorphism and cancer risk.	Arginine	85-88	tumor protein p53	Homo sapiens	72-75
29951436-12	2017	Conclusion: Our study revealed that p53 codon 72 Arg&gt;Pro polymorphism was not associated with overall cancer odds in Iranian population.	Arginine	49-52	tumor protein p53	Homo sapiens	36-39
29292255-5	2017	RESULTS: Among the 9 protein arginine methylation enzyme family genes that were tissue?specifically expressed in the DRG, Prmt2 and Prmt3 showed the highest and Prmt6 showed the lowest basal expression.	Arginine	29-37	protein arginine N-methyltransferase 3	Mus musculus	132-137
29025897-3	2017	A single nucleotide polymorphism (SNP) variant in human TRIB3, which results in a glutamine (Q) to arginine (R) missense mutation in a conserved motif at position 84, confers stronger Akt binding, resulting in reduced Akt phosphorylation, and is associated with a predisposition to Type 2 diabetes, cardiovascular disease, diabetic nephropathy, chronic kidney disease and leukemogenesis.	Arginine	99-107	AKT serine/threonine kinase 1	Homo sapiens	184-187
29025897-3	2017	A single nucleotide polymorphism (SNP) variant in human TRIB3, which results in a glutamine (Q) to arginine (R) missense mutation in a conserved motif at position 84, confers stronger Akt binding, resulting in reduced Akt phosphorylation, and is associated with a predisposition to Type 2 diabetes, cardiovascular disease, diabetic nephropathy, chronic kidney disease and leukemogenesis.	Arginine	99-107	AKT serine/threonine kinase 1	Homo sapiens	218-221
29025897-6	2017	Consistent with the functional conservation of this arginine in modulating Akt activity, mouse Trib3 R84 misexpressed in the fly fat body blocked dAkt phosphorylation with a strength similar to wild-type Trbl.	Arginine	52-60	thymoma viral proto-oncogene 1	Mus musculus	75-78
30263714-3	2017	l-Arginine significantly induced the gene expression of GH and IGF-1 in GH3 pituitary epithelium and HepG2 hepatocytes respectively, and reduced IGF binding protein-1 gene expression in HepG2 cells assessed via quantitative polymerase chain reaction analysis.	Arginine	0-10	insulin like growth factor 1	Homo sapiens	63-68
30263714-4	2017	l-Arginine also significantly induced GH and IGF-1 hormone secretion from GH3 and HepG2 cells, respectively.	Arginine	0-10	insulin like growth factor 1	Homo sapiens	45-50
30263714-5	2017	In addition, the multi-target ELISA analysis conducted revealed that phosphorylation of p-38 MAPK, MEK, and JNK were significantly increased in HepG2 cells, suggesting l-arginine-induced activation of the MAPK signaling pathway.	Arginine	168-178	mitogen-activated protein kinase kinase 7	Homo sapiens	99-102
30263714-5	2017	In addition, the multi-target ELISA analysis conducted revealed that phosphorylation of p-38 MAPK, MEK, and JNK were significantly increased in HepG2 cells, suggesting l-arginine-induced activation of the MAPK signaling pathway.	Arginine	168-178	mitogen-activated protein kinase 8	Homo sapiens	108-111
30263714-6	2017	These results suggest that l-arginine promotes the synthesis and secretion of GH and IGF-1 in vitro and induces the MAPK signaling cascade in cultured hepatocytes.	Arginine	27-37	insulin like growth factor 1	Homo sapiens	85-90
28992603-4	2017	Moreover, two SNPs (CYP17 -34 T:C (MSP AI) and CYP19 T:C (Trp:Arg)) of cytochrome P450, which is involved in steroid metabolism pathways, were analysed between the groups.	Arginine	62-65	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	47-52
29129203-3	2017	Here we report that a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth transmembrane region (S4) but to a cytosolic downstream region (S4-S5 linker).	Arginine	33-41	two pore segment channel 1	Homo sapiens	112-116
29024618-1	2017	BACKGROUND: Our previous study suggested that a lower l-arginine level (&lt;70muM) at early gestation is associated with pregnancy-induced hypertension.	Arginine	54-64	latexin	Homo sapiens	78-81
29079528-5	2017	Six early lysine (Amadori) and one advanced arginine glycation were detected in Trf.	Arginine	44-52	telomeric repeat binding factor 1	Homo sapiens	80-83
29038915-0	2017	Glycation of Lys-16 and Arg-5 in amyloid-beta and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer"s disease.	Arginine	24-27	amyloid beta precursor protein	Homo sapiens	33-45
29415833-0	2017	Short-term l-arginine supplementation attenuates elevation of interleukin 6 level after resistance exercise in overweight men.	Arginine	11-21	interleukin 6	Homo sapiens	62-75
29415833-10	2017	IL-6 levels increased significantly after exercise in the placebo group compared with the l-arg group (P &lt; 0.05).	Arginine	90-95	interleukin 6	Homo sapiens	0-4
29415833-12	2017	The IL-6/IL-10 ratio showed a statistically significant increase in the placebo group after exercise compared to the l-arg group (P &lt; 0.05).	Arginine	117-122	interleukin 6	Homo sapiens	4-8
28677244-9	2017	Five of nine phthalate compounds and cortisol shared a hydrogen bonding interaction with the Arg-252 residue of CBG.	Arginine	93-96	serpin family A member 6	Homo sapiens	112-115
29038915-4	2017	Mass spectral (MS) analysis of the reactions of Abeta with two representative sugars, ribose-5-phosphate (R5P) and methylglyoxal (MG), revealed Lys-16 and Arg-5 as the primary glycation sites.	Arginine	155-158	amyloid beta precursor protein	Homo sapiens	48-53
29302583-3	2017	The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant.	Arginine	102-105	tumor protein p53	Homo sapiens	66-69
29040630-2	2017	Objective: To investigate both acute insulin response to arginine at hyperglycemia (AIRmax), as a correlate of beta cell mass, and beta cell function by the intravenous glucose tolerance test (IVGTT) in subjects at early stages of T1D.	Arginine	57-65	insulin	Homo sapiens	37-44
29302583-3	2017	The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant.	Arginine	102-105	tumor protein p53	Homo sapiens	116-120
28919396-9	2017	Interestingly, CGA reduced the serum and pancreatic levels of macrophage migration inhibitory factor (MIF) in mice with l-arginine-induced pancreatitis.	Arginine	120-130	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	62-100
28386107-2	2017	As with ABL, translocations that fuse ARG to ETV6/TEL have been identified in patients with leukemia.	Arginine	38-41	ETS variant transcription factor 6	Homo sapiens	50-53
28919396-9	2017	Interestingly, CGA reduced the serum and pancreatic levels of macrophage migration inhibitory factor (MIF) in mice with l-arginine-induced pancreatitis.	Arginine	120-130	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	102-105
29096248-3	2017	We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p.	Arginine	25-28	fibrinogen beta chain	Homo sapiens	96-106
28165180-1	2017	BACKGROUND: Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide).	Arginine	131-141	insulin	Homo sapiens	26-33
29094484-0	2017	Degradation of AMPK-alpha1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.	Arginine	81-89	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	38-42
28648831-1	2017	Alterations in arginine metabolism and accelerated formation of advanced glycation end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1).	Arginine	15-23	glucagon	Homo sapiens	170-193
28648831-1	2017	Alterations in arginine metabolism and accelerated formation of advanced glycation end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1).	Arginine	15-23	glucagon	Homo sapiens	195-200
28648831-4	2017	By binding to its widely distributed receptor, GLP-1 blunts the effects of RAGE activation and arginine dysregulation.	Arginine	95-103	glucagon	Homo sapiens	47-52
29099132-6	2017	Using biotinylated histone H4 as a substrate, and S-adenosyl-l-methionine as a methyl donor, PRMT5 symmetrically dimethylated H4 at arginine (R) 3.	Arginine	132-140	protein arginine methyltransferase 5	Homo sapiens	93-98
29079688-1	2017	A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders.	Arginine	73-81	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	122-135
29079688-1	2017	A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders.	Arginine	73-81	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	137-142
29079688-1	2017	A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders.	Arginine	83-86	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	122-135
29079688-1	2017	A single nucleotide polymorphism substitution from glutamine (Gln, Q) to arginine (Arg, R) at codon 460 of the purinergic P2X7 receptor (P2X7R) has repeatedly been associated with mood disorders.	Arginine	83-86	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	137-142
29126407-7	2017	RESULTS: Patients with Arg/Arg and Arg/Pro at codon 72 of TP53 had a higher complete response rate (61% vs. 44%, P = 0.007) than those with Pro/Pro.	Arginine	23-26	tumor protein p53	Homo sapiens	58-62
29155876-2	2017	Our group found a variant with a single nucleotide polymorphism in the IL13 gene at position +2044G&gt;A (rs20541) that was expected to result in the non-conservative replacement of a positively charged arginine (R) with a neutral glutamine (Q) at position 144.	Arginine	203-211	interleukin 13	Homo sapiens	71-75
28987270-9	2017	Our qRT-PCR exerted that there was a continuous elevation of iNOS and COX-2 genes expression over 6 and 24h after pilocarpine administration in SE and L-arginine+Zolpidem groups while in AG/L-NAME+Zolpidem and zolpidem groups this upregulation was prevented.	Arginine	151-161	nitric oxide synthase 2	Rattus norvegicus	61-65
29118143-0	2017	Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.	Arginine	21-29	tudor and KH domain containing	Homo sapiens	79-84
29118143-5	2017	Unlike most other Tudor domains, the extended Tudor domain of mammalian Tudor domain-containing protein 2 (TDRD2) preferentially recognizes an unmethylated arginine-rich sequence from PIWI-like protein 1 (PIWIL1).	Arginine	156-164	tudor and KH domain containing	Homo sapiens	72-105
29118143-5	2017	Unlike most other Tudor domains, the extended Tudor domain of mammalian Tudor domain-containing protein 2 (TDRD2) preferentially recognizes an unmethylated arginine-rich sequence from PIWI-like protein 1 (PIWIL1).	Arginine	156-164	tudor and KH domain containing	Homo sapiens	107-112
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	70-73	DNA damage inducible transcript 3	Homo sapiens	29-33
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	70-73	DNA damage inducible transcript 3	Homo sapiens	37-41
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	74-77	DNA damage inducible transcript 3	Homo sapiens	29-33
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	74-77	DNA damage inducible transcript 3	Homo sapiens	37-41
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	74-77	DNA damage inducible transcript 3	Homo sapiens	29-33
29126407-8	2017	In the subgroup treated with CHOP or CHOP-like therapy, patients with Arg/Arg and Arg/Pro showed a higher 5-year overall survival (OS) rate than those with Pro/Pro (68.8% vs. 23.2%, P = 0.001).	Arginine	74-77	DNA damage inducible transcript 3	Homo sapiens	37-41
28977470-3	2017	ZNF326 is symmetrically dimethylated at arginine 175 (R175) and this modification is lost in a PRMT5 and WDR77-dependent manner.	Arginine	40-48	zinc finger protein 326	Homo sapiens	0-6
28977470-3	2017	ZNF326 is symmetrically dimethylated at arginine 175 (R175) and this modification is lost in a PRMT5 and WDR77-dependent manner.	Arginine	40-48	protein arginine methyltransferase 5	Homo sapiens	95-100
28612866-5	2017	A putative mechanism of retention in the cytoplasm of cells could be the interaction of the complex with inducible nitric oxide synthase (iNOS), which is the enzyme responsible for the catalytic oxidation of l-Arg to citrulline and nitric oxide.	Arginine	208-213	nitric oxide synthase 2	Homo sapiens	105-136
28741166-13	2017	CONCLUSIONS: Our results indicate that DDAH-1 expression is increased in human HCC, which is associated with an increase in the arginine/ADMA ratio and enhanced NO formation.	Arginine	128-136	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	39-45
28801345-3	2017	Here, the electropositive P4 pocket of HLA-DRB1 accommodates self-peptide residues containing citrulline but not arginine.	Arginine	113-121	major histocompatibility complex, class II, DR beta 1	Homo sapiens	39-47
28801345-13	2017	Consequent to the His13betaSer polymorphism and altered P4 pocket of HLA-DRB1*14:02, both citrulline and arginine were accommodated in opposite orientations.	Arginine	105-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	69-77
28801345-14	2017	Oligoclonal autoreactive CD4+ effector T cells reactive with both citrulline and arginine forms of vimentin59-71 were observed in patients with HLA-DRB1*14:02+ RA and at-risk ACPA- first-degree relatives.	Arginine	81-89	major histocompatibility complex, class II, DR beta 1	Homo sapiens	144-152
28418601-0	2017	Two arginine residues in the COOH-terminal of human beta-defensin-3 constitute an essential motif for antimicrobial activity and IL-6 production.	Arginine	4-12	interleukin 6	Homo sapiens	129-133
28766141-9	2017	The paradoxical decrease of the slope factor of the steady-state inactivation and acceleration of inactivation kinetics upon charge neutralization in segment IS4 may reflect the loss of stabilizing interactions of arginines and lysine with surrounding residues.	Arginine	214-223	IS4	Homo sapiens	158-161
28817220-7	2017	A key arginine residue in both HAI-1 and HAI-2 is responsible for their interaction with the S1 pocket in KLK14.	Arginine	6-14	kallikrein related peptidase 14	Homo sapiens	106-111
28842952-1	2017	HLA-DRB1*14:32:03 has one synonymous nucleotide change from HLA-DRB1*14:32:02at nucleotide 303 (codon 72 Arginine).	Arginine	105-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-8
28842952-1	2017	HLA-DRB1*14:32:03 has one synonymous nucleotide change from HLA-DRB1*14:32:02at nucleotide 303 (codon 72 Arginine).	Arginine	105-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	60-68
28987235-11	2017	Association of AIT with Arg supplementation was able to improve hemodynamic responses (left ventricular systolic pressure (LVSP), systolic blood pressure (SBP), +dP/dtmax, and -dP/dtmax (p&lt;0.05), likewise, decrease muscular and renal lipid peroxidation and tumor necrosis factor (TNF)-alpha, and increase interleukin (IL)-10/TNF-alpha plasmatic levels (p&lt;0.01).	Arginine	24-27	tumor necrosis factor	Rattus norvegicus	260-293
28987235-11	2017	Association of AIT with Arg supplementation was able to improve hemodynamic responses (left ventricular systolic pressure (LVSP), systolic blood pressure (SBP), +dP/dtmax, and -dP/dtmax (p&lt;0.05), likewise, decrease muscular and renal lipid peroxidation and tumor necrosis factor (TNF)-alpha, and increase interleukin (IL)-10/TNF-alpha plasmatic levels (p&lt;0.01).	Arginine	24-27	tumor necrosis factor	Rattus norvegicus	328-337
28882669-8	2017	Moreover, we used this probe to study the L-arginine-dependency of NO generation by iNOS on the level of single cells.	Arginine	42-52	nitric oxide synthase 2	Homo sapiens	84-88
28803324-2	2017	NO is a gas synthesized from Larginine (a conditionally essential amino acid) and oxygen by endothelial nitric oxide synthase (eNOS).	Arginine	29-38	nitric oxide synthase 3	Homo sapiens	92-125
28612866-5	2017	A putative mechanism of retention in the cytoplasm of cells could be the interaction of the complex with inducible nitric oxide synthase (iNOS), which is the enzyme responsible for the catalytic oxidation of l-Arg to citrulline and nitric oxide.	Arginine	208-213	nitric oxide synthase 2	Homo sapiens	138-142
29204107-2	2017	The CD13-targeting moiety NGR was synthesized and cyclized by native chemical ligation (NCL) instead of disulfide bridging, leading to a cyclic peptide backbone: cyclo(Cys-Asn-Gly-Arg-Gly) (coNGR).	Arginine	180-183	reticulon 4 receptor	Mus musculus	26-29
28893906-7	2017	On the basis of a homology model of the 35-amino acid NTR of MYO1C35 (NTR35) docked to the X-ray structure of MYO1CC, we predicted that MYO1C35 NTR residue Arg-21 would engage in a specific interaction with post-relay helix residue Glu-469, which affects the mechanics of the myosin power stroke.	Arginine	156-159	myosin IC	Homo sapiens	61-66
28579117-2	2017	The core sequence of NDP-alpha-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs).	Arginine	44-47	proopiomelanocortin	Homo sapiens	25-34
29065155-3	2017	Here we demonstrate that PRMT5 interacts with the HBV core (HBc) protein and dimethylates arginine residues within the arginine-rich domain (ARD) of the carboxyl-terminus.	Arginine	90-98	protein arginine methyltransferase 5	Homo sapiens	25-30
29065155-3	2017	Here we demonstrate that PRMT5 interacts with the HBV core (HBc) protein and dimethylates arginine residues within the arginine-rich domain (ARD) of the carboxyl-terminus.	Arginine	119-127	protein arginine methyltransferase 5	Homo sapiens	25-30
29033328-10	2017	We propose that plants sense multiple abiotic stresses through the Cys-Arg/N-end rule pathway either directly (via oxygen sensing) or indirectly (via NO sensing downstream of NR activity).	Arginine	71-74	nitrate reductase 1	Arabidopsis thaliana	175-177
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Arginine	131-134	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
28814503-4	2017	This conformational change unveils a region of the N-terminal cytosolic tail targeted by the Art1 alpha-arrestin, which is activated via the TORC1 kinase complex upon arginine uptake.	Arginine	167-175	Ldb19p	Saccharomyces cerevisiae S288C	93-97
28991911-5	2017	In contrast to other IgG subclasses, IgG3 is highly polymorphic and usually contains an arginine at position 435, which reduces its binding affinity to FcRn in vitro.	Arginine	88-96	Fc gamma receptor and transporter	Homo sapiens	152-156
27862398-0	2017	Milk protein responses to balanced amino acid and removal of Leucine and Arginine supplied from jugular-infused amino acid mixture in lactating dairy cows.	Arginine	73-81	Weaning weight-maternal milk	Bos taurus	0-4
27862398-1	2017	This study was undertaken to evaluate the milk protein response when cows were supplied a balanced AA profile and to determine whether a deficiency of Leucine (Leu) or Arginine (Arg) had a negative effect on milk protein.	Arginine	168-176	Weaning weight-maternal milk	Bos taurus	208-212
27862398-1	2017	This study was undertaken to evaluate the milk protein response when cows were supplied a balanced AA profile and to determine whether a deficiency of Leucine (Leu) or Arginine (Arg) had a negative effect on milk protein.	Arginine	168-171	Weaning weight-maternal milk	Bos taurus	208-212
27862398-9	2017	The -Arg treatment decreased the plasma Arg concentration than the Casein treatment, whereby resulted in the decrease of milk yield (5.7%, p = 0.073), milk protein yield (60 g, p = 0.011) and milk protein efficiency (0.04, p = 0.037).	Arginine	5-8	Weaning weight-maternal milk	Bos taurus	121-125
27862398-9	2017	The -Arg treatment decreased the plasma Arg concentration than the Casein treatment, whereby resulted in the decrease of milk yield (5.7%, p = 0.073), milk protein yield (60 g, p = 0.011) and milk protein efficiency (0.04, p = 0.037).	Arginine	5-8	Weaning weight-maternal milk	Bos taurus	151-155
28864764-3	2017	Because interaction of kindlin-2 with alphaVbeta3 requires the C-terminal three residues of the beta3 cytoplasmic tail (Arg-Gly-Thr; RGT), optogenetic probes LOVpep and ePDZ1 were fused to beta3DeltaRGT-GFP and mCherry-kindlin-2, respectively, and expressed in beta3 integrin-null microvascular endothelial cells.	Arginine	120-123	FERM domain containing kindlin 2	Homo sapiens	23-32
28815970-7	2017	Structural and affinity analyses reveal that the CBP bromodomain prefers an aromatic residue at the -2 position and an arginine at the -4 position from the acetyl-lysine, and that the CBP bromodomain selectively recognizes an extended conformation of the H3 alphaN helix that contains H3K56ac.	Arginine	119-127	CREB binding protein	Homo sapiens	49-52
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Arginine	143-146	tumor protein p53	Homo sapiens	22-25
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Arginine	147-150	tumor protein p53	Homo sapiens	22-25
29308362-6	2017	Molecular analysis of p53 codon 72 gene polymorphism was performed by polymerase chain reaction - restriction fragment length polymorphism for Arg/Arg, Arg/Pro, and Pro/Pro.	Arginine	147-150	tumor protein p53	Homo sapiens	22-25
29308362-8	2017	Results: Genotype frequencies of 35 carcinoma cases of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 23%, 57%, and 20%, respectively, and six leukoplakia cases of p53 Arg/Arg and Arg/Pro genotype were 50% and 50%, respectively.	Arginine	59-62	tumor protein p53	Homo sapiens	55-58
28551094-4	2017	METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr705, and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin.	Arginine	131-134	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
28523359-0	2017	Arginine CGA codons as a source of nonsense mutations: a possible role in multivariant gene expression, control of mRNA quality, and aging.	Arginine	0-8	chromogranin A	Homo sapiens	9-12
28523359-8	2017	As a special case, in the biosynthesis of a particular group of proteins called selenoproteins, the mutation CGA UGA would not lead to the premature translation termination and NMD but rather to the insertion of selenocysteine or cysteine instead of former arginine.	Arginine	257-265	chromogranin A	Homo sapiens	109-112
28523359-3	2017	Among CG-containing codons, CGA codons for arginine are unique due to their ability to create stop codons TGA (UGA in mRNA) upon epigenetic-mediated mutation.	Arginine	43-51	chromogranin A	Homo sapiens	28-31
28523359-11	2017	A hypothesis was put forward highlighting a role of arginine CGA codons together with glutamine CAA and CAG codons in the control of mRNA quality and life span.	Arginine	52-60	chromogranin A	Homo sapiens	61-64
28894006-7	2017	Observation of a network of interchain interactions, as established by NOE spectroscopy, shows the importance of Phe and Arg interactions in driving the phase separation of Ddx4, while the salt dependence of both low- and high-concentration regions of phase diagrams establishes an important role for electrostatic interactions.	Arginine	121-124	DEAD-box helicase 4	Homo sapiens	173-177
29033912-10	2017	The conversion of arginine to citrulline increases the peptide binding affinity to HLA-DRB1SE.	Arginine	18-26	major histocompatibility complex, class II, DR beta 1	Homo sapiens	83-86
29018805-5	2017	Using surface plasmon resonance we demonstrated that Grb7-SH2 binding to G7-18NATE is reduced 3.3-fold when the arginine is mutated to the corresponding Grb2 amino acid.	Arginine	112-120	growth factor receptor bound protein 2	Homo sapiens	153-157
29018805-6	2017	The reverse mutation in Grb2-SH2 (serine to arginine), however, was insufficient to restore binding of G7-18NATE to Grb2-SH2.	Arginine	44-52	growth factor receptor bound protein 2	Homo sapiens	24-28
28791342-0	2017	Generation of a novel TRAIL mutant by proline to arginine substitution based on codon bias and its antitumor effects.	Arginine	49-57	TNF superfamily member 10	Homo sapiens	22-27
29018805-4	2017	We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing protein that shares the same consensus binding motif as Grb7.	Arginine	19-27	growth factor receptor bound protein 2	Homo sapiens	77-81
28812766-6	2017	Arginine supplementation up-regulated muscle HSP70 and HSP90 and serum HSP70, however, none of the amino acids affected the HSP25.	Arginine	0-8	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	55-60
28695568-5	2017	We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs.	Arginine	31-39	signal transducer and activator of transcription 3	Mus musculus	54-59
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	histone deacetylase 2	Homo sapiens	33-38
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-98
28883660-5	2017	We previously demonstrated that ASS1 silencing is controlled by HIF-1alpha and Arg starvation-reactivated ASS1 is associated with HIF-1alpha downregulation.	Arginine	79-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	histone deacetylase 2	Homo sapiens	59-64
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	egl-9 family hypoxia inducible factor 1	Homo sapiens	199-203
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	hypoxia inducible factor 1 subunit alpha	Homo sapiens	216-226
28883660-10	2017	Arg starvation induces PHD2 and HDAC2 interaction which is sensitive to antioxidants.	Arginine	0-3	egl-9 family hypoxia inducible factor 1	Homo sapiens	23-27
28883660-10	2017	Arg starvation induces PHD2 and HDAC2 interaction which is sensitive to antioxidants.	Arginine	0-3	histone deacetylase 2	Homo sapiens	32-37
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	glutathione peroxidase 3	Homo sapiens	69-73
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	93-96	tumor protein p53	Homo sapiens	192-195
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	197-200	tumor protein p53	Homo sapiens	85-88
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	197-200	tumor protein p53	Homo sapiens	192-195
28874563-5	2017	We present evidence that PRMT7-mediated monomethylation of histone H4 Arg-17 regulates PRMT5 activity at Arg-3 in the same protein.	Arginine	70-73	protein arginine methyltransferase 5	Homo sapiens	87-92
28874563-5	2017	We present evidence that PRMT7-mediated monomethylation of histone H4 Arg-17 regulates PRMT5 activity at Arg-3 in the same protein.	Arginine	105-108	protein arginine methyltransferase 5	Homo sapiens	87-92
28874563-8	2017	Most interestingly, monomethylation at Arg-17 in histone H4 not only raised the general activity of PRMT5 with this substrate, but also ameliorated the low activity of PRMT5 at low substrate concentrations.	Arginine	39-42	protein arginine methyltransferase 5	Homo sapiens	100-105
28874563-8	2017	Most interestingly, monomethylation at Arg-17 in histone H4 not only raised the general activity of PRMT5 with this substrate, but also ameliorated the low activity of PRMT5 at low substrate concentrations.	Arginine	39-42	protein arginine methyltransferase 5	Homo sapiens	168-173
28943853-6	2017	Ablation of Arg-II gene significantly reduces the aging marker p16INK4a levels in these tissues of old female mice, whereas in the male mice this effect of Arg-II deficiency is weaker.	Arginine	12-15	cyclin dependent kinase inhibitor 2A	Mus musculus	63-71
28943853-10	2017	Genetic disruption of Arg-II in mouse extends lifespan predominantly in females, which relates to inhibition of S6K1, p66Shc, and p16INK4a.	Arginine	22-25	cyclin dependent kinase inhibitor 2A	Mus musculus	130-138
28874603-6	2017	An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi.	Arginine	3-6	tumor protein p53	Homo sapiens	72-75
28874603-6	2017	An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi.	Arginine	3-6	tumor protein p53	Homo sapiens	77-80
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	nuclear factor kappa B subunit 1	Homo sapiens	93-101
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	superoxide dismutase 1	Homo sapiens	110-114
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	glutamate-cysteine ligase modifier subunit	Homo sapiens	119-123
28857739-7	2017	Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.	Arginine	14-17	tumor protein p53	Homo sapiens	10-13
28857739-7	2017	Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.	Arginine	18-21	tumor protein p53	Homo sapiens	10-13
28857739-7	2017	Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.	Arginine	18-21	tumor protein p53	Homo sapiens	10-13
28857739-7	2017	Moreover, p53 arg/arg patients infected by an HPV16 prototype strain were associated with an increased risk of more severe lesions, while a significant relationship between the p53 arg/arg genotype in patients with T350G sequence variation and the risk of high-grade squamous intraepithelial lesions (HSILs) was revealed.	Arginine	18-21	tumor protein p53	Homo sapiens	10-13
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	89-92	tumor protein p53	Homo sapiens	85-88
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	89-92	tumor protein p53	Homo sapiens	192-195
28857739-8	2017	CONCLUSION: The oncogenic potential of the virus is increased by the presence of the p53 arg/arg genotype in the Greek population in such a way that the specific protein interaction E6 (L83V)-p53 (Arg-72) can modify an individual"s susceptibility to cervical disease.	Arginine	93-96	tumor protein p53	Homo sapiens	85-88
28904082-2	2017	We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages.	Arginine	109-119	nitric oxide synthase 3	Homo sapiens	58-91
28904082-10	2017	The relative L-arginine deficiency may be related to elevated levels of the methylarginine L-NMMA, which would compete with L-arginine for eNOS and for intracellular transport, reducing NO biosynthesis.	Arginine	13-23	nitric oxide synthase 3	Homo sapiens	139-143
28904082-2	2017	We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages.	Arginine	109-119	nitric oxide synthase 3	Homo sapiens	93-97
28273031-9	2017	The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p &lt;= 0.046).	Arginine	69-72	interleukin 1 beta	Rattus norvegicus	9-17
28851320-7	2017	In the multiple regression analysis performed in cilostazol group, serum L-arginine levels were inversely correlated with FMD at T1 (ss = -0.050, SE: 0.012, p &lt; 0.001) with age, total cholesterol levels, and C-reactive protein as confounders.	Arginine	73-83	C-reactive protein	Homo sapiens	211-229
28784805-0	2017	Histone phosphorylation by TRPM6"s cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.	Arginine	70-78	transient receptor potential cation channel, subfamily M, member 6	Mus musculus	27-32
28716421-2	2017	Ornithine decarboxylase (ODC) converts ornithine directly to putrescine, while a second route for putrescine biosynthesis utilizes arginine decarboxylase (ADC) to convert arginine to agmatine, and two additional enzymes, agmatine iminohydrolase (AIH) and N-carbamoyl putrescine aminohydrolase (NLP1) to complete this pathway.	Arginine	131-139	nitrilase-like protein 1	Arabidopsis thaliana	294-298
28811641-6	2017	Citrullination of integrin ligands was selected for further studies since fibronectin R234 in isoDGR was among the most frequently citrullinated arginines in synovial fluid.	Arginine	145-154	fibronectin 1	Homo sapiens	74-85
28813479-10	2017	The functional consequence of increased ADMA and decreased L-arginine in context of all cumulative metabolic changes in plasma resulted in reduced iNOS supporting activity associated with sepsis.	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	147-151
28672221-3	2017	Two, processing of diarginyl insulin, produced in the latter process, by carboxypeptidase B then needed to be rapid to remove the two arginine residues, Three, both these operations were to be efficient whether the N-terminal methionine was acylated or not.	Arginine	134-142	insulin	Homo sapiens	29-36
28797075-1	2017	AIMS: Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals.	Arginine	6-14	nitric oxide synthase 2	Homo sapiens	30-61
28797075-1	2017	AIMS: Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals.	Arginine	6-14	nitric oxide synthase 2	Homo sapiens	63-67
28797075-5	2017	RESULTS: Asthmatics with high FENO (&gt;= 35 ppb; 44% of asthmatics) had higher expression of iNOS (P = 0.04) and ARG2 (P = 0.05) in the airway, indicating FENO is a marker of the high arginine metabolic endotype.	Arginine	185-193	nitric oxide synthase 2	Homo sapiens	94-98
28450045-0	2017	Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes.	Arginine	0-8	cathelicidin antimicrobial peptide	Homo sapiens	39-44
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	91-94	AKT serine/threonine kinase 1	Homo sapiens	232-235
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	91-94	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	192-196
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	224-227	AKT serine/threonine kinase 1	Homo sapiens	115-118
28854561-1	2017	Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
28436014-3	2017	We assessed the extent to which the pharmacokinetic characteristics are a function of the staple for a peptide inhibiting the interaction of p53 with the human double minute 2 (Hdm2) protein and differ from those of the standard cationic cell-penetrating peptide nona-arginine.	Arginine	268-276	tumor protein p53	Homo sapiens	141-144
28854561-1	2017	Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	174-179
28236308-5	2017	In cell culture-based models for HBV infection and in liver tissues of patients with chronic HBV infection, we found that symmetric dimethylation of arginine 3 on H4 on cccDNA was a repressive marker of cccDNA transcription and was regulated by PRMT5 depending on its methyltransferase domain.	Arginine	149-157	protein arginine methyltransferase 5	Homo sapiens	245-250
28236308-6	2017	Moreover, PRMT5-triggered symmetric dimethylation of arginine 3 on H4 on the cccDNA minichromosome involved an interaction with the HBV core protein and the Brg1-based human SWI/SNF chromatin remodeler, which resulted in down-regulation of the binding of RNA polymerase II to cccDNA.	Arginine	53-61	protein arginine methyltransferase 5	Homo sapiens	10-15
28798743-5	2017	Infection of THP-1-derived macrophage/human monocyte-derived macrophage (hMDM) with Leishmania, resulted in upregulation of l-arginine transport.	Arginine	124-134	GLI family zinc finger 2	Homo sapiens	13-18
28755537-1	2017	OBJECTIVE: Data on the effect of gender on the interpretation of the GHRH plus arginine stimulation test (GHRH+ARG test) is controversial.	Arginine	79-87	growth hormone releasing hormone	Homo sapiens	106-110
28755537-11	2017	CONCLUSIONS: The GH response to stimulation by GHRH+ARG is gender-dependent, being lower in healthy males than in females.	Arginine	52-55	growth hormone releasing hormone	Homo sapiens	47-51
27381509-4	2017	Arginine residue in 521 position (R521) of PY-NLS plays a vital role in the binding of FUS protein with Kapbeta2.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	87-90
28659245-8	2017	Using an arginine cutoff of 60muM and an arginine/(phenylalanine x leucine) ratio of 1.4, reportedly used in one screening program, or the R4S Tool Runner, would have resulted in a recall rate of &lt;0.005%.	Arginine	9-17	latexin	Homo sapiens	30-33
28789369-5	2017	Notably, the Pro72 allele was significantly enriched in patients with ESCC compared with its abundance in the healthy control group, and the genotype of Pro/Arg on p53 codon 72 was confirmed to exhibit a significant correlation with ESCC in Mongolian patients.	Arginine	157-160	tumor protein p53	Homo sapiens	164-167
28789369-7	2017	Mongolian patients who carry the partocular genotype of Arg/Pro or Pro/Pro on p53 codon 72 may be more likely to develop ESCC.	Arginine	56-59	tumor protein p53	Homo sapiens	78-81
28658579-6	2017	These findings highlight the importance of the conformational plasticity and accessibility of the arginine-glycine-aspartic acid (RGD) binding site in FN, which, in turn, mediates cell signaling in physiological and synthetic environments.	Arginine	98-106	fibronectin 1	Homo sapiens	151-153
28640323-4	2017	Mutation of one, two, or three Lys residues or the Arg residue alone decreased the catalytic efficiency of TAFI activation by thrombin-TM by 2.4-, 3.2-, 4.7-, and 15.0-fold, respectively, and increased the TAFI concentrations required for half-maximal prolongation of clot lysis times (K1/2) by 3-, 4,- 15-, and 24-fold, respectively.	Arginine	51-54	coagulation factor II, thrombin	Homo sapiens	126-134
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Arginine	38-41	coagulation factor II, thrombin	Homo sapiens	95-103
28727810-4	2017	Unexpectedly, a CMV mutant, designated CMVRA that harbors an alanine substitution in the N-terminal arginine-rich region of the coat protein (CP) persistently invaded the SAM and resulted in visible reductions in apical dominance.	Arginine	100-108	golgi phosphoprotein 3	Homo sapiens	128-140
28791021-5	2017	Here, we demonstrate that anti-CD3/anti-CD28-activated human primary CD4+ and CD8+ T cells upregulate ASS expression in response to low extracellular arginine concentrations, while ASL is expressed constitutively.	Arginine	150-158	CD4 molecule	Homo sapiens	69-72
28727810-4	2017	Unexpectedly, a CMV mutant, designated CMVRA that harbors an alanine substitution in the N-terminal arginine-rich region of the coat protein (CP) persistently invaded the SAM and resulted in visible reductions in apical dominance.	Arginine	100-108	golgi phosphoprotein 3	Homo sapiens	142-144
28714883-2	2017	The central sequence of alpha-MSH (His-Phe-Arg-Trp) has been identified as being essential for receptor binding.	Arginine	43-46	proopiomelanocortin	Homo sapiens	24-33
28644004-10	2017	Strikingly, a marked increase in the rate of arginine methylation was observed for PRMT3.	Arginine	45-53	protein arginine methyltransferase 3	Homo sapiens	83-88
28644004-11	2017	Finally, N-terminal acetylation reduced the rate of arginine methylation by PRMT3 but had little influence on PRMT1, -5, and -8 activity.	Arginine	52-60	protein arginine methyltransferase 3	Homo sapiens	76-81
28750050-10	2017	Arg697 in KpPriA is known to play a critical role in altering the SSB35/SSB65 distribution, but this corresponding residue in SaPriA is Glu767 instead, which has an opposite charge to Arg.	Arginine	0-3	AT695_RS13435	Staphylococcus aureus	66-69
28644004-6	2017	Our studies found that acylations of H4K5 resulted in decreased levels of arginine methylation by PRMT1, PRMT3, and PRMT8.	Arginine	74-82	protein arginine methyltransferase 3	Homo sapiens	105-110
28644004-7	2017	In contrast, PRMT5 exhibits an increased rate of arginine methylation upon H4K5 acetylation, propionylation, and crotonylation, but not upon H4K5 methylation, butyrylation, or 2-hydroxyisobutyrylation.	Arginine	49-57	protein arginine methyltransferase 5	Homo sapiens	13-18
28671612-6	2017	The extraordinary loss of arginine may be attributed to some extent to composition of its codons as well as to the importance of arginine in the functioning of prominent tumor suppressor proteins like p53.	Arginine	26-34	tumor protein p53	Homo sapiens	201-204
28708111-5	2017	A review of all current studies would suggest that IPC/RIPC relies on creating a small tissue injury resulting in the release of adenosine and l-arginine which act through the Adenosine receptors and the haem-oxygenase and endothelial nitric oxide synthase systems to reduce hepatocyte necrosis and improve the hepatic microcirculation post reperfusion.	Arginine	143-153	nitric oxide synthase 3	Homo sapiens	223-256
28678843-8	2017	Reduction in arginine methylation correlated with the binding of ORF59 on the viral chromatin and disruption of PRMT5 from its adapter protein, COPR5 (cooperator of PRMT5).	Arginine	13-21	protein arginine methyltransferase 5	Homo sapiens	112-117
28678843-8	2017	Reduction in arginine methylation correlated with the binding of ORF59 on the viral chromatin and disruption of PRMT5 from its adapter protein, COPR5 (cooperator of PRMT5).	Arginine	13-21	coordinator of PRMT5 and differentiation stimulator	Homo sapiens	144-149
28678843-8	2017	Reduction in arginine methylation correlated with the binding of ORF59 on the viral chromatin and disruption of PRMT5 from its adapter protein, COPR5 (cooperator of PRMT5).	Arginine	13-21	protein arginine methyltransferase 5	Homo sapiens	165-170
28678843-9	2017	Binding of PRMT5 through COPR5 is important for symmetric methylation of H4R3 and the expression of ORF59 competitively reduces the association of PRMT5 with COPR5, leading to a reduction in PRMT5 mediated arginine methylation.	Arginine	206-214	protein arginine methyltransferase 5	Homo sapiens	11-16
28678843-9	2017	Binding of PRMT5 through COPR5 is important for symmetric methylation of H4R3 and the expression of ORF59 competitively reduces the association of PRMT5 with COPR5, leading to a reduction in PRMT5 mediated arginine methylation.	Arginine	206-214	coordinator of PRMT5 and differentiation stimulator	Homo sapiens	25-30
28678843-9	2017	Binding of PRMT5 through COPR5 is important for symmetric methylation of H4R3 and the expression of ORF59 competitively reduces the association of PRMT5 with COPR5, leading to a reduction in PRMT5 mediated arginine methylation.	Arginine	206-214	protein arginine methyltransferase 5	Homo sapiens	147-152
28678843-9	2017	Binding of PRMT5 through COPR5 is important for symmetric methylation of H4R3 and the expression of ORF59 competitively reduces the association of PRMT5 with COPR5, leading to a reduction in PRMT5 mediated arginine methylation.	Arginine	206-214	coordinator of PRMT5 and differentiation stimulator	Homo sapiens	158-163
28678843-9	2017	Binding of PRMT5 through COPR5 is important for symmetric methylation of H4R3 and the expression of ORF59 competitively reduces the association of PRMT5 with COPR5, leading to a reduction in PRMT5 mediated arginine methylation.	Arginine	206-214	protein arginine methyltransferase 5	Homo sapiens	147-152
28698590-1	2017	Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain.	Arginine	119-127	tudor domain containing 3	Homo sapiens	0-33
28698590-1	2017	Tudor domain containing protein 3 (TDRD3) is a modular protein identified based on its ability to recognize methylated arginine motifs through its Tudor domain.	Arginine	119-127	tudor domain containing 3	Homo sapiens	35-40
28683085-1	2017	Coagulation Factor VIII is activated by an ordered limited thrombin proteolysis with different catalytic efficiency at three P1 Arginine residues: Arg759&gt; Arg1708&gt;Arg391, indicating the flanking residues of the latter to be less optimal.	Arginine	128-136	coagulation factor II, thrombin	Homo sapiens	59-67
28903384-6	2017	Mechanistic studies further revealed that PRMT5 (Protein arginine methyltransferase 5), responsible for catalyzing arginine methylation on histones, is a novel cofactor of SHARPIN.	Arginine	57-65	protein arginine methyltransferase 5	Homo sapiens	42-47
28671612-6	2017	The extraordinary loss of arginine may be attributed to some extent to composition of its codons as well as to the importance of arginine in the functioning of prominent tumor suppressor proteins like p53.	Arginine	129-137	tumor protein p53	Homo sapiens	201-204
28389817-6	2017	Arginine mutants of DmHsp22 are efficient chaperones to retard aggregation of CS and Luc.	Arginine	0-8	Heat shock protein 22	Drosophila melanogaster	20-27
28285006-7	2017	Conversion of lysine to arginine at these two sites did not affect subcellular localization, but did affect the transcriptional activity of GATA5.	Arginine	24-32	GATA binding protein 5	Danio rerio	140-145
28475405-3	2017	A common coding region variant at amino acid 72 of p53 encodes either proline (P72) or arginine (R72).	Arginine	87-95	tumor protein p53	Homo sapiens	51-54
28389817-7	2017	In summary, this study shows that mutations of arginine to glycine in DmHsp22 ACD induce a number of structural changes, some of which differ from those described in mammalian sHsps.	Arginine	47-55	Heat shock protein 22	Drosophila melanogaster	70-77
28727112-8	2017	For 21-d-old broilers, IOF of the 1% Arg solution increased ( &lt; 0.05) the concentrations of ghrelin and glucagon-like peptide 2; the activities of digestive enzymes, alkaline phosphatase, maltase, and sucrase in the jejunum; and the concentrations of serum AA of Val, Met, Ile, Leu, Arg, and Pro compared with those of the noninjected control and diluent-injected group.	Arginine	37-40	glucagon	Homo sapiens	107-130
28455769-3	2017	NO is synthesized from L-arginine by endothelial NO synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	49-60
28954469-2	2017	Our current study was aimed to explore the effect of L-arginine on skin fibroblast (L929) signaling pathways involved in cell proliferation (Akt-pAkt kinase, Erk/pErk1/2 kinase, JNK/pJNK kinase and pStat-1), apoptosis (Bcl2 and Bax) and immune defense (NF-kappaB and CD26).	Arginine	53-63	thymoma viral proto-oncogene 1	Mus musculus	141-144
28954469-2	2017	Our current study was aimed to explore the effect of L-arginine on skin fibroblast (L929) signaling pathways involved in cell proliferation (Akt-pAkt kinase, Erk/pErk1/2 kinase, JNK/pJNK kinase and pStat-1), apoptosis (Bcl2 and Bax) and immune defense (NF-kappaB and CD26).	Arginine	53-63	B cell leukemia/lymphoma 2	Mus musculus	219-223
28954469-5	2017	The exposure of skin fibroblasts to L-arginine increased anti-apoptotic Bcl2/Bax stoichiometry ratio (p&lt;0.05), obtained by calculation of their individual quantities.	Arginine	36-46	B cell leukemia/lymphoma 2	Mus musculus	72-76
28654706-8	2017	ENOS-cofactors dynamic assay showed that Hsp90 enhanced WT eNOS affinity to NADPH, L-arginine, and CaM but not to Ca2+ and BH4.	Arginine	83-93	nitric oxide synthase 3	Bos taurus	0-4
28401430-6	2017	Preferentially bound excipients (propanediol and arginine) suppressed BSA aggregation, but arginine failed to inhibit OVA aggregation, which might be attributed to the disparate conformational perturbing effects of arginine on aromatic hydrophobic regions of BSA and OVA.	Arginine	49-57	albumin	Homo sapiens	70-73
28654706-8	2017	ENOS-cofactors dynamic assay showed that Hsp90 enhanced WT eNOS affinity to NADPH, L-arginine, and CaM but not to Ca2+ and BH4.	Arginine	83-93	nitric oxide synthase 3	Bos taurus	59-63
28654706-13	2017	In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability.	Arginine	146-156	nitric oxide synthase 3	Bos taurus	27-31
28654706-13	2017	In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability.	Arginine	146-156	nitric oxide synthase 3	Bos taurus	69-73
28654706-13	2017	In conclusion, by changing eNOS structure, Hsp90 profoundly affected eNOS functions, including change of affinity of eNOS to cofactors like Ca2+, L-arginine, BH4 and further affecting NO generation capability.	Arginine	146-156	nitric oxide synthase 3	Bos taurus	69-73
28483572-4	2017	We found that l-arginine and M40403 restored diabetes-induced impairment of phospho-5"-AMP-activated protein kinase alpha (AMPKalpha) signaling by upregulating AMPKalpha protein itself and its downstream effectors, peroxisome proliferator-activated receptor-gamma coactivator-1alpha and nuclear respiratory factor 1.	Arginine	14-24	nuclear respiratory factor 1	Rattus norvegicus	287-315
28483572-4	2017	We found that l-arginine and M40403 restored diabetes-induced impairment of phospho-5"-AMP-activated protein kinase alpha (AMPKalpha) signaling by upregulating AMPKalpha protein itself and its downstream effectors, peroxisome proliferator-activated receptor-gamma coactivator-1alpha and nuclear respiratory factor 1.	Arginine	14-24	PPARG coactivator 1 alpha	Rattus norvegicus	215-282
28617308-2	2017	Diabetes can reduce NO by increasing ROS and by increasing activity of arginase, which competes with nitric oxide synthase (NOS) for their commons substrate l-arginine.	Arginine	157-167	nitric oxide synthase 2	Homo sapiens	101-122
28535671-3	2017	Treatment with Arg + MeSA not only enhanced the activities of superoxide dismutase, catalase, and peroxidase but also promoted the expression levels of pathogenesis-related protein 1 gene and the activities of defense-related enzymes of phenylalanine ammonia-lyase, polyphenol oxidase, beta-1,3-glucanase, and chitinase during most of the storage periods, which were associated with lower disease incidence and disease index.	Arginine	15-18	phenylalanine ammonia-lyase	Solanum lycopersicum	237-264
28665920-4	2017	alpha-like cells (iAlpha cells) were generated from mouse fibroblasts by transduction of transcription factors, including Hhex, Foxa3, Gata4, Pdx1 and Pax4, which induce alpha-cell-specific gene expression and glucagon secretion in response to KCl and Arg stimulation.	Arginine	252-255	hematopoietically expressed homeobox	Mus musculus	122-126
28342021-9	2017	In addition, in the MAPK signaling pathway, pSAPK/JNK and p-Erk1/2 in LPS with Arg-Arg treatment were upregulated than that in LPS treatment.	Arginine	79-82	mitogen-activated protein kinase 1	Mus musculus	20-24
28559318-2	2017	However, apoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine in apoE3.	Arginine	88-96	apolipoprotein E	Homo sapiens	9-14
28559318-2	2017	However, apoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine in apoE3.	Arginine	88-96	apolipoprotein E	Homo sapiens	28-33
28559318-2	2017	However, apoE4 differs from apoE3 by only a single amino acid at position 112, which is arginine in apoE4 and cysteine in apoE3.	Arginine	88-96	apolipoprotein E	Homo sapiens	100-105
28701241-8	2017	Supplementation with Arg significantly decreased crypt depth (P&lt;0 05), suppressed CAT-1 mRNA expression induced by diquat (P&lt;0 05), increased ARGII and endothelial nitric oxide synthase mRNA levels (P&lt;0 05), and effectively relieved the TNF- alpha mRNA expression induced by diquat in the jejunum (P&lt;0 05).	Arginine	21-24	tumor necrosis factor	Homo sapiens	246-256
28356354-1	2017	The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus.	Arginine	110-118	transportin 3	Homo sapiens	16-31
28356354-1	2017	The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus.	Arginine	110-118	transportin 3	Homo sapiens	33-40
28356354-1	2017	The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus.	Arginine	110-118	transportin 3	Homo sapiens	42-47
28462834-3	2017	X-ray crystallography shows that the 1,2,3-triazol-4-one/ol acts as a carboxylic acid isostere, making a bi-dentate interaction with an arginine residue of Sortilin, an interaction which has not been previously characterised for this heterocycle.	Arginine	136-144	sortilin 1	Homo sapiens	156-164
28342021-9	2017	In addition, in the MAPK signaling pathway, pSAPK/JNK and p-Erk1/2 in LPS with Arg-Arg treatment were upregulated than that in LPS treatment.	Arginine	83-86	mitogen-activated protein kinase 1	Mus musculus	20-24
28374504-1	2017	Nitric oxide synthase (NOS) catalyses the production of nitric oxide (NO) from L-Arginine, which participates in diverse biological processes including inflammation and apoptosis.	Arginine	79-89	nitric oxide synthase 2	Homo sapiens	0-21
28559451-5	2017	Surface plasmon resonance and crystallography studies revealed that the arginine-to-leucine polymorphism within ULBP0602 affected the NKG2D-ULBP6 interaction by generating an energetic hotspot.	Arginine	72-80	retinoic acid early transcript 1L	Homo sapiens	140-145
28558680-9	2017	Arginine supplementation increased the gene expression of FABP1, which contributes for triacylglycerols synthesis without affecting hepatic fatty acids content.	Arginine	0-8	fatty acid binding protein 1	Sus scrofa	58-63
28315470-7	2017	Bioinformatic analysis identified differentially regulated pathways where NOS2 is known to play an important role including citrulline/arginine metabolism, epithelial cell junctions and oxidative stress.	Arginine	135-143	nitric oxide synthase 2	Homo sapiens	74-78
28515311-6	2017	These and related results revealed a major role of Nt-acetylation in the Hsp90-mediated protein homeostasis, a strong up-regulation of the Arg/N-end rule pathway in the absence of NatA, and showed that a number of Hsp90 clients are previously unknown substrates of the Arg/N-end rule pathway.	Arginine	269-272	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	214-219
28515311-2	2017	Chk1, a mitotic checkpoint kinase and a client of Hsp90, was degraded relatively slowly in wild-type cells but was rapidly destroyed in naa10Delta cells by the Arg/N-end rule pathway, which recognized a C terminus-proximal degron of Chk1.	Arginine	160-163	serine/threonine protein kinase CHK1	Saccharomyces cerevisiae S288C	0-4
28314095-4	2017	Residues in the Pim1 catalytic domain interacting directly with a critical arginine residue in the substrate were substituted to produce a kinase mutant that instead accommodates a hydrophobic residue.	Arginine	75-83	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	16-20
28515311-2	2017	Chk1, a mitotic checkpoint kinase and a client of Hsp90, was degraded relatively slowly in wild-type cells but was rapidly destroyed in naa10Delta cells by the Arg/N-end rule pathway, which recognized a C terminus-proximal degron of Chk1.	Arginine	160-163	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	50-55
28515311-2	2017	Chk1, a mitotic checkpoint kinase and a client of Hsp90, was degraded relatively slowly in wild-type cells but was rapidly destroyed in naa10Delta cells by the Arg/N-end rule pathway, which recognized a C terminus-proximal degron of Chk1.	Arginine	160-163	serine/threonine protein kinase CHK1	Saccharomyces cerevisiae S288C	233-237
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	serine/threonine protein kinase CHK1	Saccharomyces cerevisiae S288C	33-37
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	204-209
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	221-226
28515311-4	2017	Protection of Chk1 by Hsp90 could be overridden not only by ablation of the NatA Nt-acetylase but also by overexpression of the Arg/N-end rule pathway in wild-type cells.	Arginine	128-131	serine/threonine protein kinase CHK1	Saccharomyces cerevisiae S288C	14-18
28515311-4	2017	Protection of Chk1 by Hsp90 could be overridden not only by ablation of the NatA Nt-acetylase but also by overexpression of the Arg/N-end rule pathway in wild-type cells.	Arginine	128-131	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	22-27
28525989-4	2017	Of these, only the SNP, c.271C &gt; T (rs442346530), in exon 5 of CDKN1A gene was predicted to result in an amino acid replacement from arginine to tryptophan.	Arginine	136-144	cyclin dependent kinase inhibitor 1A	Bos taurus	66-72
28513569-7	2017	Arg administration promoted mobilization of circulating proangiogenic cells while it downregulated the production of inflammatory cytokines and expression of Angpt/Tie-2 genes in the lung.	Arginine	0-3	TEK receptor tyrosine kinase	Mus musculus	164-169
28513569-8	2017	The results of this investigation suggested that intravenous administration of Arg shortly after the onset of sepsis enhanced the mobilization of circulating proangiogenic cells, maintained the homeostasis of the Angpt/Tie-2 axis, and attenuated remote organ injury in polymicrobial sepsis.	Arginine	79-82	TEK receptor tyrosine kinase	Mus musculus	219-224
28489004-5	2017	We found that heightened ERK signaling activity in aRG is tightly linked to the temporal formation and the relative abundance of bRG in human and mouse cortices.	Arginine	51-54	mitogen-activated protein kinase 1	Homo sapiens	25-28
28302728-4	2017	Using thrombin as the protease, Cdc50p remains intact and in complex with Drs2p, which is cleaved at two positions, namely after Arg104 and after Arg 1290, resulting in a homogeneous sample lacking 104 and 65 residues from its N and C termini, respectively.	Arginine	129-132	aminophospholipid translocase regulatory protein CDC50	Saccharomyces cerevisiae S288C	32-38
28484595-6	2017	Supplementing functional amino acids (e.g., arginine and glutamine) and vitamins (e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation.	Arginine	44-52	mechanistic target of rapamycin kinase	Homo sapiens	130-159
28409923-1	2017	The unusual Met-Tyr-Trp adduct composed of cross-linked side chains along with an associated mobile Arg is essential for catalase activity in catalase-peroxidases.	Arginine	100-103	catalase	Homo sapiens	121-129
28214592-4	2017	We found that the polymorphism rs1042522:C &gt; G in codon 72 of exon 4 of the TP53 gene, whose C variant produces a proline and is more common in most ethnicities, has a G variant producing an arginine in 79.8% of NFPAs (n = 42; p &lt; 1.411 x 10-18 vs. 1000 Genomes database), causing patients to present a decade earlier with symptomatic NFPAs.	Arginine	194-202	tumor protein p53	Homo sapiens	79-83
28409923-1	2017	The unusual Met-Tyr-Trp adduct composed of cross-linked side chains along with an associated mobile Arg is essential for catalase activity in catalase-peroxidases.	Arginine	100-103	catalase	Homo sapiens	142-150
28260165-2	2017	The present study tested the hypothesis that L-arginine stimulates growth and development of brown adipocyte precursor cells (BAPCs) through activation of mammalian target of rapamycin cell signaling.	Arginine	45-55	mechanistic target of rapamycin kinase	Homo sapiens	155-184
28237651-10	2017	In summary, rat GIP(3-30)NH2 is a high affinity competitive GIPR antagonist and effectively antagonizes GIP-mediated G protein-signaling as well as pancreatic hormone release, while human GIP(3-30)NH2, despite a difference of only one amino acid between the two (arginine in position 18 in rat GIP(3-30)NH2; histidine in human), is unsuitable in the rat system.	Arginine	263-271	gastric inhibitory polypeptide	Rattus norvegicus	16-19
28131820-5	2017	All the results pointing that arginine and lysine residues of chymase play the most significant role in inhibitor binding revealed by energy decomposition.	Arginine	30-38	chymase 1	Homo sapiens	62-69
28415785-3	2017	We report that inhibition of nitric oxide synthase (NOS) significantly induced cell apoptosis (p &lt; 0.05), and promoted the rate of Arginine uptake and the expressions of protein for CAT-2 and y+LAT-1 (p &lt; 0.05), while reduced protein expression of CAT-1.	Arginine	134-142	nitric oxide synthase 2	Sus scrofa	29-50
28415785-4	2017	And NOS inhibition markedly decreased the activation of mammalian target of rapamycin (mTOR) and PI3K-Akt pathways by Arginine in the IPEC-1 cells (p &lt; 0.05).	Arginine	118-126	mechanistic target of rapamycin kinase	Homo sapiens	56-85
28415785-4	2017	And NOS inhibition markedly decreased the activation of mammalian target of rapamycin (mTOR) and PI3K-Akt pathways by Arginine in the IPEC-1 cells (p &lt; 0.05).	Arginine	118-126	mechanistic target of rapamycin kinase	Homo sapiens	87-91
28093506-3	2017	Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes.	Arginine	52-60	anorexia	Mus musculus	161-164
28093506-3	2017	Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes.	Arginine	52-60	anorexia	Mus musculus	219-222
28840768-1	2017	HBD: c.442T&gt;C is a new mutation at the stop codon (TGA&gt;CGA) of the delta-globin gene, which produces a new codon for arginine.	Arginine	123-131	chromogranin A	Homo sapiens	61-64
28198180-5	2017	CLPs containing 120 GFP molecules and those containing approximately 150 dye molecules were both shown to bind human integrin via a naturally occurring Arg-Gly-Asp motif found on an exposed loop of the VP7 trimeric spike.	Arginine	152-155	colipase	Homo sapiens	0-4
28198180-5	2017	CLPs containing 120 GFP molecules and those containing approximately 150 dye molecules were both shown to bind human integrin via a naturally occurring Arg-Gly-Asp motif found on an exposed loop of the VP7 trimeric spike.	Arginine	152-155	VP7	Bluetongue virus	202-205
28176353-4	2017	TRPA1 and TRPV1 channels are activated by intracellular LPA, but not by extracellular LPA following LPA5 receptor activation with an activity of Ca2+ -independent phospholipase A2 and phospholipase D. Intracellular LPA interaction sites of TRPA1 are KK672-673 and KR977-978 (K: lysine, R: arginine).	Arginine	289-297	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	10-15
28410371-8	2017	Two arginine residues (131 and 203) in the HNF1A protein are highly conserved residues and contribute to the function of the protein.	Arginine	4-12	HNF1 homeobox A	Homo sapiens	43-48
28223245-0	2017	Potential of single cationic amino acid molecule "Arginine" for stimulating oral absorption of insulin.	Arginine	50-58	insulin	Homo sapiens	95-102
28223245-4	2017	The results demonstrated that a remarkable enhancement of intestinal insulin absorption was observed after coadministration of insulin with l-arginine.	Arginine	140-150	insulin	Homo sapiens	69-76
28223245-8	2017	Oral administration study in mice demonstrated that the stronger hypoglycemic effects were observed after coadministration of insulin with l-arginine.	Arginine	139-149	insulin	Homo sapiens	126-133
28223245-9	2017	In this study, we found that arginine is a key cationic amino acid for delivering insulin across intestinal epithelial barriers and hopefully accelerating the clinical development of oral insulin delivery systems.	Arginine	29-37	insulin	Homo sapiens	82-89
28071686-11	2017	ARG1 and NOS3 in cluster 4 were enriched in biological process of arginine catabolic process.	Arginine	66-74	nitric oxide synthase 3	Homo sapiens	9-13
27355867-9	2017	Altogether, these data suggest that swapping residue 188 identity effectively flips the membrane binding profile of wild-type RhoA and RhoC through positive arginine contribution rather than negative phosphoserine regulation.	Arginine	157-165	ras homolog family member A	Homo sapiens	126-130
28740730-3	2017	Arginine and glutamate activate both interleukin-2 and lysozyme with a concentration dependence of the saturation type.	Arginine	0-8	interleukin 15	Gallus gallus	37-50
28143899-7	2017	The missense mutation (p.C391R) reported here results in the replacement of a conserved cysteine residue by an arginine in the CULT (cereblon domain of unknown activity, binding cellular ligands and thalidomide) domain of CRBN, which contains a zinc-binding site.	Arginine	111-119	cereblon	Homo sapiens	222-226
28512575-1	2017	Multiple possibilities for the coordination of fac-[Re(CO)3(H2O)3]+ to a protein have been determined and include binding to Asp, Glu, Arg and His amino-acid residues as well as to the C-terminal carboxylate in the vicinity of Leu and Pro.	Arginine	135-138	FA complementation group C	Homo sapiens	47-50
27714957-1	2017	Protein arginine methyltransferase 5 (PRMT5) is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate proteins.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
28334039-0	2017	L-arginine attenuates Interleukin-1beta (IL-1beta) induced Nuclear Factor Kappa-Beta (NF-kappaB) activation in Caco-2 cells.	Arginine	0-10	interleukin 1 beta	Homo sapiens	22-39
28186725-9	2017	Free energy calculations for the wild-type and mutant uPAR bound to uPA or 12 show that Arg-53 interacts with uPA or with 12 in a highly cooperative manner, thereby altering the contributions of hot spots to uPAR binding.	Arginine	88-91	plasminogen activator, urokinase	Homo sapiens	54-57
28186725-9	2017	Free energy calculations for the wild-type and mutant uPAR bound to uPA or 12 show that Arg-53 interacts with uPA or with 12 in a highly cooperative manner, thereby altering the contributions of hot spots to uPAR binding.	Arginine	88-91	plasminogen activator, urokinase	Homo sapiens	68-71
28334039-0	2017	L-arginine attenuates Interleukin-1beta (IL-1beta) induced Nuclear Factor Kappa-Beta (NF-kappaB) activation in Caco-2 cells.	Arginine	0-10	interleukin 1 beta	Homo sapiens	41-49
28334039-9	2017	SNP attenuated the IL-1beta-induced increase in NF-kappaB luciferase activity and expression, whereas NNA diminished the inhibitory effects of L-Arg on IL-1beta-inducible NF- kappaB luciferase activity.	Arginine	143-148	interleukin 1 beta	Homo sapiens	152-160
28334039-0	2017	L-arginine attenuates Interleukin-1beta (IL-1beta) induced Nuclear Factor Kappa-Beta (NF-kappaB) activation in Caco-2 cells.	Arginine	0-10	nuclear factor kappa B subunit 1	Homo sapiens	86-95
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	interleukin 1 beta	Homo sapiens	47-55
28367063-10	2017	In addition, PD-L1/PD1 engagement can induce autophagy in nearby T-cells due to a decrease in the amino acids tryptophan and arginine and due to the deprivation of nutrients such as glucose followed by a reduction in glucose metabolism.	Arginine	125-133	CD274 molecule	Sus scrofa	13-18
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	nuclear factor kappa B subunit 1	Homo sapiens	65-74
28334039-2	2017	We hypothesized the anti-inflammatory effects of L-Arg require active transport and metabolism by inducible nitric oxide synthase (iNOS) to generate nitric oxide (NO).	Arginine	49-54	nitric oxide synthase 2	Homo sapiens	98-129
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	interleukin 1 beta	Homo sapiens	158-166
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	nuclear factor kappa B subunit 1	Homo sapiens	189-198
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	nitric oxide synthase 2	Homo sapiens	222-226
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	110-115	interleukin 1 beta	Homo sapiens	47-55
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	110-115	nuclear factor kappa B subunit 1	Homo sapiens	65-74
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	43-48	nuclear factor kappa B subunit 1	Homo sapiens	52-61
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	43-48	nitric oxide synthase 2	Homo sapiens	97-101
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	43-48	interleukin 1 beta	Homo sapiens	165-173
28334039-2	2017	We hypothesized the anti-inflammatory effects of L-Arg require active transport and metabolism by inducible nitric oxide synthase (iNOS) to generate nitric oxide (NO).	Arginine	49-54	nitric oxide synthase 2	Homo sapiens	131-135
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	43-48	nuclear factor kappa B subunit 1	Homo sapiens	183-192
28334039-7	2017	RESULTS: IL-1beta increased NF-kappaB luciferase activity (8-fold) and NF-kappaB expression (mRNA and protein), both of these were significantly decreased by L-Arg.	Arginine	158-163	interleukin 1 beta	Homo sapiens	9-17
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	156-161	nuclear factor kappa B subunit 1	Homo sapiens	52-61
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	156-161	nitric oxide synthase 2	Homo sapiens	97-101
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	156-161	interleukin 1 beta	Homo sapiens	165-173
28334039-7	2017	RESULTS: IL-1beta increased NF-kappaB luciferase activity (8-fold) and NF-kappaB expression (mRNA and protein), both of these were significantly decreased by L-Arg.	Arginine	158-163	nuclear factor kappa B subunit 1	Homo sapiens	28-37
28334039-11	2017	Our data suggest the inhibitory effects of L-Arg on NF-kappaB activation are mediated in part by iNOS since SNP preserves and NNA attenuates the effects of L-Arg on IL-1beta-mediated NF-kappaB-activation and expression.	Arginine	156-161	nuclear factor kappa B subunit 1	Homo sapiens	183-192
28334039-7	2017	RESULTS: IL-1beta increased NF-kappaB luciferase activity (8-fold) and NF-kappaB expression (mRNA and protein), both of these were significantly decreased by L-Arg.	Arginine	158-163	nuclear factor kappa B subunit 1	Homo sapiens	71-80
28289592-3	2016	A G&gt;T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg Cys mutation reported in all cases of porcine stress syndrome (PSS).	Arginine	90-98	ryanodine receptor 1	Homo sapiens	31-35
28214233-1	2017	An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA.	Arginine	3-11	golgin B1	Homo sapiens	91-94
28287151-4	2017	Lys-rich sequences (EK3 (AEEEKKK) and EK2R1 (AEEEKRK)) both form SAHs, of which EK2R1 is more helical and thermo-stable suggesting Arg increases stability.	Arginine	131-134	EPH receptor A8	Homo sapiens	20-23
28287151-5	2017	Substituting Lys with Arg (or vice versa) in the naturally-occurring myosin-6 SAH similarly increased (or decreased) its stability.	Arginine	22-25	myosin heavy chain 6	Homo sapiens	69-77
28263986-3	2017	TDRD6 also associates with spliceosomal core protein SmB in the absence of RNA and in an arginine methylation dependent manner.	Arginine	89-97	tudor domain containing 6	Homo sapiens	0-5
28289592-3	2016	A G&gt;T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg Cys mutation reported in all cases of porcine stress syndrome (PSS).	Arginine	188-191	ryanodine receptor 1	Homo sapiens	31-35
28223511-5	2017	We isolated substitutions, locating to the transmembrane helix of TatB that restored transport activity to Tat signal peptides with inactivating twin arginine substitutions.	Arginine	150-158	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	66-69
28263986-4	2017	In Tdrd6-/- diplotene spermatocytes PRMT5 association with SmB and arginine dimethylation of SmB are much reduced.	Arginine	67-75	tudor domain containing 6	Homo sapiens	3-8
27730472-2	2017	The aim is to prospectively compare the growth hormone deficiency/insulin-like growth factor-1 status of 71 human immunodeficiency virus-infected patients with impaired growth hormone response to growth hormone releasing hormone + Arginine with that of 65 hypopituitary patients affected by a true growth hormone deficiency secondary to pituitary disease.	Arginine	231-239	growth hormone 1	Homo sapiens	169-183
28238654-6	2017	Taken together, our findings reveal the importance of PRMT5-mediated arginine methylation during DSB repair pathway choice through its ability to regulate acetylation-dependent control of 53BP1 localization.	Arginine	69-77	protein arginine methyltransferase 5	Homo sapiens	54-59
27913198-7	2017	Mechanistically, the Gln-deprivation response, like the arginine-auxotrophic response, downregulates HIF-1alpha resulting in de-silencing of ASS1.	Arginine	56-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	101-111
27546619-1	2017	Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme that mainly represses transcription of target genes via symmetric dimethylation of arginine residues on histones H4R3, H3R8 and H2AR3.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
26826259-7	2017	Glutamine, arginine, and vitamin D3, but not ALA, significantly attenuated IL-8 production.	Arginine	11-19	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
28611978-6	2017	KEY MESSAGE: High rates of tumor suppressor gene p53 mutations, particularly p53 arginine mutations, were detected in pancreatic cancer patients.	Arginine	81-89	tumor protein p53	Homo sapiens	49-52
28611978-6	2017	KEY MESSAGE: High rates of tumor suppressor gene p53 mutations, particularly p53 arginine mutations, were detected in pancreatic cancer patients.	Arginine	81-89	tumor protein p53	Homo sapiens	77-80
28611978-8	2017	Oral bacteria peptidylarginine deiminases might lead to the p53 and K-ras point mutations by degrading arginine.	Arginine	22-30	tumor protein p53	Homo sapiens	60-63
27903843-8	2017	Together, these results show that the treatment with iNOS and Arg inhibitors leads to increased expression of co-stimulatory molecules in DCs, and provides evidences that L-arginine metabolism may be an important therapeutic target for modulating immune responses in inflammatory disorders.	Arginine	171-181	nitric oxide synthase 2, inducible	Mus musculus	53-57
27903463-6	2017	Structural analysis of HER2 TMD association revealed that mutations at positions V659 and G660 to the highly polar residues glutamic acid, aspartic acid, or arginine should stabilize homodimerization and heterodimerization of HER2 in the active conformation.	Arginine	157-165	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
27903463-6	2017	Structural analysis of HER2 TMD association revealed that mutations at positions V659 and G660 to the highly polar residues glutamic acid, aspartic acid, or arginine should stabilize homodimerization and heterodimerization of HER2 in the active conformation.	Arginine	157-165	erb-b2 receptor tyrosine kinase 2	Homo sapiens	226-230
26826259-8	2017	Glutamine and arginine led to phosphorylation blockade of the signaling components in NF-kappaB and P38 pathways, reduction in kinase activity, and enhancement in NO production.	Arginine	14-22	mitogen-activated protein kinase 14	Homo sapiens	100-103
26826259-9	2017	Combining glutamine, arginine, and curcumin at optimal concentrations completely abolished the IL-8 response.	Arginine	21-29	C-X-C motif chemokine ligand 8	Homo sapiens	95-99
27569446-1	2017	Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1), endothelial (NOS3), and inducible (NOS2) nitric oxide synthases.	Arginine	61-71	nitric oxide synthase 2	Homo sapiens	127-131
28138708-1	2017	Arginine-specific mono-ADP-ribosyltransferase 1 (ART1) is an important enzyme that catalyzes arginine-specific mono-ADP-ribosylation.	Arginine	93-101	ADP-ribosyltransferase 1	Mus musculus	0-47
28138708-1	2017	Arginine-specific mono-ADP-ribosyltransferase 1 (ART1) is an important enzyme that catalyzes arginine-specific mono-ADP-ribosylation.	Arginine	93-101	ADP-ribosyltransferase 1	Mus musculus	49-53
28140572-2	2017	The guanidine moiety of arginine is involved in the active sites of a variety of enzymes, such as nitric oxide synthase (NOS) and NiFe hydrogenase.	Arginine	24-32	nitric oxide synthase 2	Homo sapiens	98-119
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Arginine	124-127	fibrinogen beta chain	Homo sapiens	28-38
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Arginine	124-127	fibrinogen beta chain	Homo sapiens	190-200
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Arginine	124-127	fibrinogen beta chain	Homo sapiens	190-200
29296957-2	2017	The interaction between the fibrinogen C-terminal gamma-chain peptide composed of residues gamma-404-411 (GAKQAGDV) and the Arg-Gly-Asp (RGD) binding pocket on alphaIIbbeta3 is required for fibrinogen-mediated platelet aggregation, but data suggest that other ancillary binding sites on both fibrinogen and alphaIIbbeta3 may lead to higher-affinity fibrinogen binding and clot retraction.	Arginine	124-127	fibrinogen beta chain	Homo sapiens	190-200
28069708-7	2017	Arginine substitution of the ubiquitylated lysine impairs this inactivation mechanism and results in unrestrained FGFR1 ubiquitylation in cells.	Arginine	0-8	fibroblast growth factor receptor 1	Homo sapiens	114-119
28357076-5	2017	The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93).	Arginine	43-51	tumor protein p53	Homo sapiens	30-33
27987858-4	2017	The in vitro antitumor efficacy of Arg-CNCs co-delivering paclitaxel and recombinant human caspase-3 was evaluated in HeLa cells.	Arginine	35-38	caspase 3	Homo sapiens	91-100
28074644-3	2017	Herein, inspired by viral structures that are optimized for gene delivery, we designed a small-molecule gene vector (TR4) with aggregation-induced emission properties by capping a peptide containing four arginine residues with tetraphenylethene (TPE) and a lipophilic tail.	Arginine	204-212	nuclear receptor subfamily 2 group C member 2	Homo sapiens	117-120
27903582-1	2017	l-Arginine (L-Arg) is the substrate for nitric oxide synthase (NOS) to produce nitric oxide (NO), a signaling molecule that is key in cardiovascular physiology and pathology.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	40-61
27903582-1	2017	l-Arginine (L-Arg) is the substrate for nitric oxide synthase (NOS) to produce nitric oxide (NO), a signaling molecule that is key in cardiovascular physiology and pathology.	Arginine	12-17	nitric oxide synthase 2	Homo sapiens	40-61
28382155-3	2017	Lactam bridge-cyclized alpha-melanocyte-stimulating hormone (Ac-Nle4-cyclo[Asp5-His-D-Phe7-Arg-Trp-Lys10]-NH2, or Nle-CycMSHhex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT).	Arginine	91-94	melanocortin 1 receptor	Mus musculus	188-192
28357076-5	2017	The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93).	Arginine	53-56	tumor protein p53	Homo sapiens	30-33
28357076-5	2017	The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93).	Arginine	58-61	tumor protein p53	Homo sapiens	30-33
28357076-5	2017	The distribution frequency of p53 sites of arginine (Arg)/Arg, Arg/proline (Pro), Pro/Pro were 18.4, 48.8 and 32.8% in the control group, as compared with 18.7, 49.9 and 31.4% in the case group, which indicated that there was no difference between two groups (chi2=0.14; P=0.93).	Arginine	58-61	tumor protein p53	Homo sapiens	30-33
26732027-10	2017	The GH/IGF-1 axis was evaluated by peak GH response after GHRH + ARGININE and IGF-1 standard deviation score (SDS).	Arginine	65-73	insulin like growth factor 1	Homo sapiens	7-12
28045576-5	2017	We found that L-arginine significantly elevated the number of splenic CD8+ T-cells, the level of serum interferon-gamma, and CD8+ T-cell infiltration.	Arginine	14-24	interferon gamma	Mus musculus	103-119
27400413-5	2017	We identify PADI2 as one of the most highly upregulated transcripts in BMMSCs from both MGUS and MM patients, and that through its enzymatic deimination of histone H3 arginine 26, PADI2 activity directly induces the upregulation of interleukin-6 expression.	Arginine	167-175	interleukin 6	Homo sapiens	232-245
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Arginine	25-34	thymoma viral proto-oncogene 1	Mus musculus	68-71
27909743-9	2017	Stimulation of RASMCs with IL-1beta caused a marked increase in transplasmalemmal L-arginine uptake into RASMCs.	Arginine	82-92	interleukin 1 beta	Rattus norvegicus	27-35
27909743-10	2017	L-Arginine uptake in the presence of IL-1beta was markedly inhibited by R59949, while basal L-arginine uptake was not significantly affected by R59949.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	37-45
27909743-11	2017	Both IL-1beta-induced NO production and L-arginine uptake were abolished in the presence of cycloheximide (1 muM).	Arginine	40-50	interleukin 1 beta	Rattus norvegicus	5-13
28035420-3	2017	Our laboratory has previously demonstrated that arginine metabolic enzyme argininosuccinate lyase (ASL) promoted HCC formation in part via maintenance of cyclin A2 protein expression and arginine production for channeling to nitric oxide synthase.	Arginine	48-56	cyclin A2	Homo sapiens	154-163
27921110-4	2017	In this study, we report the use of polyethyleneimine (PEI)-entrapped gold nanoparticles (Au PENPs) modified with an arginine-glycine-aspartic (Arg-Gly-Asp, RGD) peptide via a poly(ethylene glycol) (PEG) spacer as a vector for Bcl-2 (B-cell lymphoma-2) siRNA delivery to glioblastoma cells.	Arginine	144-147	BCL2 apoptosis regulator	Homo sapiens	227-232
27921110-4	2017	In this study, we report the use of polyethyleneimine (PEI)-entrapped gold nanoparticles (Au PENPs) modified with an arginine-glycine-aspartic (Arg-Gly-Asp, RGD) peptide via a poly(ethylene glycol) (PEG) spacer as a vector for Bcl-2 (B-cell lymphoma-2) siRNA delivery to glioblastoma cells.	Arginine	144-147	BCL2 apoptosis regulator	Homo sapiens	234-251
28120917-2	2017	In this study, we showed that the methylation of Arg 138 and the phosphorylation of Ser 140 on p16 were critical for the control of cell proliferation and apoptosis.	Arginine	49-52	cyclin dependent kinase inhibitor 2A	Homo sapiens	95-98
28045525-4	2017	The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the native Asn of AGRP or a diaminopropionic (Dap) acid residue previously shown to increase antagonist potency at the mMC4R.	Arginine	26-29	agouti related neuropeptide	Mus musculus	102-106
28045525-4	2017	The tetrapeptide His-DPhe-Arg-Trp or tripeptide DPhe-Arg-Trp replaced the Arg-Phe-Phe sequence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the native Asn of AGRP or a diaminopropionic (Dap) acid residue previously shown to increase antagonist potency at the mMC4R.	Arginine	53-56	agouti related neuropeptide	Mus musculus	102-106
28067368-3	2017	We showed that the mRNA and protein expressions of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha were upregulated by arginine supplementation.	Arginine	177-185	CCAAT enhancer binding protein alpha	Sus scrofa	120-156
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Arginine	63-66	fibrinogen beta chain	Homo sapiens	32-42
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Arginine	67-70	fibrinogen beta chain	Homo sapiens	32-42
27929198-8	2017	Clots made from plasma-purified fibrinogen of individuals with Arg/Arg, Arg/Lys and Lys/Lys genotypes showed differences in fibre thickness (46.75 +- 8.07, 38.40 +- 6.04 and 25 +- 4.99 nm, respectively; p&lt;0.001) and clot lysis time (419 +- 64, 442 +- 87 and 517 +- 65 s, respectively; p=0.02), directly implicating the polymorphism in the observed changes.	Arginine	67-70	fibrinogen beta chain	Homo sapiens	32-42
28120917-5	2017	Furthermore, the elevated arginine methylation in p16S140A mutant and increased serine phosphorylation in p16R138K mutant suggest that a antagonizing mechanism coordinating Arg 138 methylation and Ser 140 phosphorylation to regulates p16 function as well as cellular apoptosis and senescence.	Arginine	26-34	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
27270440-0	2017	A TGFbeta-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.	Arginine	84-92	transforming growth factor beta 1	Homo sapiens	2-9
27920205-4	2017	We report that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd3+ binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5.	Arginine	15-18	transient receptor potential cation channel subfamily C member 5	Homo sapiens	66-71
27920205-4	2017	We report that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd3+ binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5.	Arginine	15-18	transient receptor potential cation channel subfamily C member 5	Homo sapiens	186-191
27270440-0	2017	A TGFbeta-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.	Arginine	84-92	protein arginine methyltransferase 5	Homo sapiens	10-15
27849571-10	2017	These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis.	Arginine	28-36	myogenic differentiation 1	Homo sapiens	112-116
27270440-1	2017	Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
28074910-0	2017	Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.	Arginine	54-62	ras homolog family member A	Homo sapiens	23-27
28074910-0	2017	Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.	Arginine	54-62	protein arginine methyltransferase 5	Homo sapiens	96-132
28074910-5	2017	Silencing of MYPT1 increased the level of the PRMT5-specific symmetric dimethylation on arginine residues of histone 2 A/4, a repressing gene expression mark, and it resulted in a global change in the expression of genes affecting cellular processes like growth, proliferation and cell death, also affecting the expression of the retinoblastoma protein and c-Myc.	Arginine	88-96	protein arginine methyltransferase 5	Homo sapiens	46-51
28074910-8	2017	Our results suggest the tumor suppressor role of MP via inhibition of PRMT5 thereby regulating gene expression through histone arginine dimethylation.	Arginine	127-135	protein arginine methyltransferase 5	Homo sapiens	70-75
27503676-7	2017	Such a proline-arginine sequence has been associated with the arginine methyl-transferases CARM1 and PRMT5.	Arginine	15-23	protein arginine methyltransferase 5	Homo sapiens	101-106
27660387-5	2017	Instead, AQP0 phosphorylation alters calcium sensitivity by modifying the AQP0-CaM interaction interface, particularly at an arginine-rich loop that connects the fourth and fifth transmembrane helices.	Arginine	125-133	major intrinsic protein of lens fiber	Homo sapiens	9-13
27624579-8	2017	The ratio of IAPP/C-peptide during the first (225 mg/dl) and second step (400 mg/dl), and in response to arginine, was decreased in T2DM versus both NGT and IGT (p &lt; 0.01).	Arginine	105-113	insulin	Homo sapiens	18-27
28849501-6	2017	Taurine and L-arginine promoted apoptosis of VSMCs via increasing the Bax protein expression and decreasing the Bcl-2 protein expression.	Arginine	12-22	BCL2, apoptosis regulator	Rattus norvegicus	112-117
28950949-9	2017	As inflammation persists, a GPI-linked carboxypeptidase M removes the C-terminal arginine from the primary kinin, converting the B2R agonist into a high-affinity ligand for B1R, a GPCR subtype that is transcriptionally upregulated in injured/inflamed tissues.	Arginine	81-89	bradykinin receptor, beta 1	Mus musculus	173-176
27660387-5	2017	Instead, AQP0 phosphorylation alters calcium sensitivity by modifying the AQP0-CaM interaction interface, particularly at an arginine-rich loop that connects the fourth and fifth transmembrane helices.	Arginine	125-133	calmodulin 1	Homo sapiens	79-82
29119105-5	2017	The mutation replaces a highly conserved arginine residue with glutamine within the Frag1 (FGF receptor activating) domain of PGAP2.	Arginine	41-49	post-GPI attachment to proteins 2	Homo sapiens	84-89
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Arginine	101-104	angiotensinogen	Rattus norvegicus	56-62
29119105-5	2017	The mutation replaces a highly conserved arginine residue with glutamine within the Frag1 (FGF receptor activating) domain of PGAP2.	Arginine	41-49	post-GPI attachment to proteins 2	Homo sapiens	126-131
28347732-0	2017	Association between the p53 arginine/arginine homozygous genotype at codon 72 and human papillomavirus E6/E7 mRNA expression.	Arginine	28-36	tumor protein p53	Homo sapiens	24-27
28347732-0	2017	Association between the p53 arginine/arginine homozygous genotype at codon 72 and human papillomavirus E6/E7 mRNA expression.	Arginine	37-45	tumor protein p53	Homo sapiens	24-27
28347732-9	2017	CONCLUSION: The presence of the p53 arginine/arginine homozygous genotype at codon 72 was significantly associated with the positive HPV E6/E7 mRNA expression.	Arginine	36-44	tumor protein p53	Homo sapiens	32-35
28347732-9	2017	CONCLUSION: The presence of the p53 arginine/arginine homozygous genotype at codon 72 was significantly associated with the positive HPV E6/E7 mRNA expression.	Arginine	45-53	tumor protein p53	Homo sapiens	32-35
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	250-291
27768124-5	2017	The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein.	Arginine	103-111	tumor protein p53	Homo sapiens	10-14
27768124-5	2017	The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein.	Arginine	103-111	tumor protein p53	Homo sapiens	11-14
27768124-9	2017	Patients harboring the Pro allele of the Tp53 Arg72Pro SNP showed higher levels of circulating EPC-containing CD34+ cells, EPC-mobilizing cytokines - vascular endothelial growth factor and stromal cell-derived factor-1alpha - and good functional outcome following ICH, when compared with the homozygous Arg allele patients, which is compatible with increased neovascularization.	Arginine	46-49	tumor protein p53	Homo sapiens	41-45
27768124-9	2017	Patients harboring the Pro allele of the Tp53 Arg72Pro SNP showed higher levels of circulating EPC-containing CD34+ cells, EPC-mobilizing cytokines - vascular endothelial growth factor and stromal cell-derived factor-1alpha - and good functional outcome following ICH, when compared with the homozygous Arg allele patients, which is compatible with increased neovascularization.	Arginine	46-49	CD34 molecule	Homo sapiens	110-114
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	293-298
28158539-0	2017	Defects in methylation of arginine 37 on CENP-A/Cse4 are compensated by the ubiquitin ligase complex Ubr2/Mub1.	Arginine	26-34	putative ubiquitin-protein ligase UBR2	Saccharomyces cerevisiae S288C	101-105
27356939-8	2017	Accumulating studies have indicated that L-arginine may have potential to prevent and/or relieve type 2 diabetes via restoring insulin sensitivity in vivo.	Arginine	41-51	insulin	Homo sapiens	127-134
28854440-0	2017	The Nrf2/HO-1 Pathway Mediates the Antagonist Effect of L-Arginine On Renal Ischemia/Reperfusion Injury in Rats.	Arginine	56-66	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
27796631-6	2017	The probe for Arg, in turn, has a linear range in the 10-180 muM concentration range, and the limit of detection is 0.5 muM.	Arginine	14-17	latexin	Homo sapiens	61-64
27796631-6	2017	The probe for Arg, in turn, has a linear range in the 10-180 muM concentration range, and the limit of detection is 0.5 muM.	Arginine	14-17	latexin	Homo sapiens	120-123
27830885-11	2017	Also, L-arg-induced AP caused a significant elevation of the serum levels of AM, LP, IL-6.	Arginine	6-11	interleukin 6	Rattus norvegicus	85-89
29333597-2	2017	TP53 codon 72 polymorphism (P72R) results in proline (P) or arginine (R) at 72 amino acid position, which causes synthesis of proteins with distinct functions.	Arginine	60-68	tumor protein p53	Homo sapiens	0-4
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Arginine	248-251	CD4 molecule	Homo sapiens	14-17
28478454-0	2017	Vascular Endothelial Growth Factor Augments Arginine Transport and Nitric Oxide Generation via a KDR Receptor Signaling Pathway.	Arginine	44-52	vascular endothelial growth factor A	Homo sapiens	0-34
28478454-3	2017	Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown to modulate eNOS activity.	Arginine	12-20	nitric oxide synthase 3	Homo sapiens	39-43
28478454-3	2017	Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown to modulate eNOS activity.	Arginine	12-20	nitric oxide synthase 3	Homo sapiens	120-124
28478454-4	2017	The current studies were designed to test the hypothesis that VEGF enhances eNOS activity via modulation of arginine transport by CAT-1.	Arginine	108-116	vascular endothelial growth factor A	Homo sapiens	62-66
28478454-8	2017	RESULTS: VEGF (50 and 100 ng/ml) significantly augmented endothelial arginine transport in a time dependent manner, an effect which was prevented by Sunitinib (2 microM), a multi targeted receptor tyrosine kinase inhibitor.	Arginine	69-77	vascular endothelial growth factor A	Homo sapiens	9-13
28478454-9	2017	The increase in arginine transport velocities by VEGF was not affected by silencing Flt-1 while silencing KDR abrogated VEGF effect.	Arginine	16-24	vascular endothelial growth factor A	Homo sapiens	49-53
28478454-14	2017	CONCLUSIONS: VEGF increases arginine transport via modulation of CAT-1 in endothelial cells.	Arginine	28-36	vascular endothelial growth factor A	Homo sapiens	13-17
28854440-7	2017	The expression levels of Nrf2, HO-1, and HSP70 were strongly increased, and the expression of NF-kappaB and production of ROS were significantly decreased in the L-arginine group compared to that of the I/R group.	Arginine	162-172	NFE2 like bZIP transcription factor 2	Rattus norvegicus	25-29
28854440-9	2017	CONCLUSION: These findings suggested that L-arginine/NO reduces renal dysfunction associated with I/R of the kidney and may act as a trigger to regulate the NF-kappaB, HSP70 and Nrf2/HO-1 signaling cascades.	Arginine	42-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	178-182
28271477-2	2017	PRMT5 in complex with MEP50/p44/WDR77 associates with a plethora of partner proteins to symmetrically dimethylate arginine residues on target proteins in both the nucleus and the cytoplasm.	Arginine	114-122	protein arginine methyltransferase 5	Homo sapiens	0-5
27761847-3	2017	Recently, the role of alphav integrins, which recognize the Arg-Gly-Asp (RGD) tripeptide, in the release and signal transduction activation of TGFbeta1 became evident.	Arginine	60-63	transforming growth factor beta 1	Homo sapiens	143-151
27875315-3	2016	A genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325), which is also a higher frequency (&gt;50%) allele, is correlated with zinc transport activity.	Arginine	202-205	solute carrier family 30 member 8	Homo sapiens	27-31
27875315-9	2016	In agreement with the human genetic finding that rare loss-of-function mutations in ZnT8 are associated with reduced T2D risk, our results suggested that the common high risk Arg-325 variant is hyperactive, and thus may be targeted for inhibition to reduce T2D risk in the general populations.	Arginine	175-178	solute carrier family 30 member 8	Homo sapiens	84-88
27956631-1	2016	Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies.	Arginine	78-86	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	46-50
27799302-5	2016	In the absence of Rictor, CD4+ T cells proliferate normally in limiting arginine or leucine.	Arginine	72-80	CD4 molecule	Homo sapiens	26-29
27803162-4	2016	The binding interface was further refined through molecular modeling and mutagenesis and shown to be comprised of complementary charged residues in the NCAM Ig2 domain (Arg-156 and Lys-162) and the EphA3 CRD (Glu-248 and Glu-264).	Arginine	169-172	neural cell adhesion molecule 1	Mus musculus	152-156
27765932-0	2016	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.	Arginine	41-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	130-140
27765932-9	2016	Using two proteasomal inhibitors bortezomib and carfilzomib which induce HIF-1alpha accumulation, we further demonstrated that HIF-1alpha is involved in ASS1 silencing for the maintenance of Arg auxotrophy for targeted Arg-starvation therapy.	Arginine	191-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
27765932-9	2016	Using two proteasomal inhibitors bortezomib and carfilzomib which induce HIF-1alpha accumulation, we further demonstrated that HIF-1alpha is involved in ASS1 silencing for the maintenance of Arg auxotrophy for targeted Arg-starvation therapy.	Arginine	219-222	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
27934952-2	2016	In microorganisms and plants, NAG is the first intermediate of the L-arginine biosynthesis; in animals, NAG is an allosteric activator of carbamylphosphate synthetase I and III.	Arginine	67-77	N-acetyl-alpha-glucosaminidase	Homo sapiens	30-33
27934952-2	2016	In microorganisms and plants, NAG is the first intermediate of the L-arginine biosynthesis; in animals, NAG is an allosteric activator of carbamylphosphate synthetase I and III.	Arginine	67-77	N-acetyl-alpha-glucosaminidase	Homo sapiens	104-107
27637923-5	2016	Additionally, ADAM15 efficiently processed Dabcyl-Leu-Arg-Glu-Gln-Gln-Arg-Leu-Lys-Ser-Lys(FAM)-NH2 (PEPDAB022), which is based on a physiological CD23 cleavage site, with a specificity constant (kcat/Km) of 5200 M-1 s-1.	Arginine	54-57	ADAM metallopeptidase domain 15	Homo sapiens	14-20
27990297-5	2016	We show that the mitochondrial stress-induced transcription coactivator hnRNAP2 acetylates Lys 8 of H4 through an intrinsic histone lysine acetyltransferase (KAT) activity with Arg 48 and Arg 50 of hnRNAP2 being essential for acetyl-CoA binding and acetyltransferase activity.	Arginine	177-180	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	158-161
27990297-5	2016	We show that the mitochondrial stress-induced transcription coactivator hnRNAP2 acetylates Lys 8 of H4 through an intrinsic histone lysine acetyltransferase (KAT) activity with Arg 48 and Arg 50 of hnRNAP2 being essential for acetyl-CoA binding and acetyltransferase activity.	Arginine	188-191	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	158-161
27914500-7	2016	RESULTS: Higher l-arginine was associated with higher risk of IHD (odds ratio [OR] 1.18 per SD increase, 95% CI 1.03-1.36) and of myocardial infarction (OR 1.29, 95% CI 1.10-1.51), based on 2 SNPs from MED23.	Arginine	16-26	mediator complex subunit 23	Homo sapiens	202-207
27637923-5	2016	Additionally, ADAM15 efficiently processed Dabcyl-Leu-Arg-Glu-Gln-Gln-Arg-Leu-Lys-Ser-Lys(FAM)-NH2 (PEPDAB022), which is based on a physiological CD23 cleavage site, with a specificity constant (kcat/Km) of 5200 M-1 s-1.	Arginine	70-73	ADAM metallopeptidase domain 15	Homo sapiens	14-20
27839876-9	2016	If l-arginine was below the cutoff value of 35 mumol/L, jugular S100B concentration was higher 24 h post-operatively (p = .03), and jugular lactate levels were increased during reperfusion (p = .02).	Arginine	3-13	S100 calcium binding protein B	Homo sapiens	64-69
28033105-6	2016	Multivariate analysis showed a significant association with NSCLC for the combination between the TP53 codon72 Arg/Pro and the Pro/Pro genotypes (OR 2.21, 95 % CI 1.390-3.51; p=0.001).	Arginine	111-114	tumor protein p53	Homo sapiens	98-102
27839876-13	2016	The inverse correlation between pre-operative l-arginine concentration and both jugular lactate and S100B during carotid clamping suggests a protective role of the NO donor l-arginine.	Arginine	46-56	S100 calcium binding protein B	Homo sapiens	100-105
27839876-13	2016	The inverse correlation between pre-operative l-arginine concentration and both jugular lactate and S100B during carotid clamping suggests a protective role of the NO donor l-arginine.	Arginine	173-183	S100 calcium binding protein B	Homo sapiens	100-105
27920724-0	2016	Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways.	Arginine	184-194	insulin	Homo sapiens	0-7
28035186-6	2016	Sequencing of the SOD1 gene by PCR revealed a missense mutation of G to C (c.37G&gt;C) in exon 1, and amino acid substitution of glycine by arginine (p.Gly13Arg).	Arginine	140-148	superoxide dismutase 1	Homo sapiens	18-22
27681598-9	2016	Furthermore, an l-ANT mutant with the P1 Ile mutated to Arg inhibits thrombin nearly 1500-fold faster than the wild type, which is further accelerated by high molecular weight heparin.	Arginine	56-59	coagulation factor II, thrombin	Homo sapiens	69-77
27733068-8	2016	RESULTS: Mice submitted to l-arginine injections developed abdominal hyperalgesia and increased serum amylase, lipase, C-reactive protein and IL-6 concentrations; and increased pancreatic myeloperoxidase activity, edema index, MDA, and 3-nitrotyrosine contents.	Arginine	27-37	interleukin 6	Mus musculus	142-146
28053964-7	2016	p53 gene polymorphism at codon 72 is statistically significant in Arg/Arg and Pro/Pro genotypes.	Arginine	66-69	tumor protein p53	Homo sapiens	0-3
28053964-7	2016	p53 gene polymorphism at codon 72 is statistically significant in Arg/Arg and Pro/Pro genotypes.	Arginine	70-73	tumor protein p53	Homo sapiens	0-3
27934649-1	2016	l-Arginine (Arg) appears to have a beneficial effect on the regulation of nutrient metabolism to enhance lean tissue deposition and on insulin resistance in humans.	Arginine	0-10	insulin	Homo sapiens	135-142
27934649-1	2016	l-Arginine (Arg) appears to have a beneficial effect on the regulation of nutrient metabolism to enhance lean tissue deposition and on insulin resistance in humans.	Arginine	2-5	insulin	Homo sapiens	135-142
27934649-5	2016	Several recent studies have shown beneficial effects of Arg in individuals with obesity, insulin resistance, and diabetes.	Arginine	56-59	insulin	Homo sapiens	89-96
29979511-3	2016	As L-arginine acts as the substrate of endothelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation.	Arginine	3-13	nitric oxide synthase 3	Homo sapiens	39-72
29979511-3	2016	As L-arginine acts as the substrate of endothelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation.	Arginine	3-13	nitric oxide synthase 3	Homo sapiens	74-78
29979511-3	2016	As L-arginine acts as the substrate of endothelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation.	Arginine	5-13	nitric oxide synthase 3	Homo sapiens	39-72
29979511-3	2016	As L-arginine acts as the substrate of endothelial nitric oxide synthase (eNOS), arginine supplementation can enhance NO formation.	Arginine	5-13	nitric oxide synthase 3	Homo sapiens	74-78
27920724-1	2016	HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxide in human placenta.The relaxation induced by insulin is dependent on BKCa channels activity in human placenta.	Arginine	60-70	insulin	Homo sapiens	38-45
27920724-1	2016	HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxide in human placenta.The relaxation induced by insulin is dependent on BKCa channels activity in human placenta.	Arginine	60-70	insulin	Homo sapiens	163-170
27920724-1	2016	HIGHLIGHTS Short-term incubation with insulin increases the L-arginine transport in HUVECs.Short-term incubation with insulin increases the NO synthesis in HUVECs.Insulin induces relaxation in human placental vascular bed.Insulin attenuates the constriction induced by hydrogen peroxide in human placenta.The relaxation induced by insulin is dependent on BKCa channels activity in human placenta.	Arginine	60-70	insulin	Homo sapiens	222-229
27920724-8	2016	Insulin increases L-arginine transport and NO synthesis in HUVECs.	Arginine	18-28	insulin	Homo sapiens	0-7
27920724-11	2016	Insulin rapidly dilates the placental vasculature through a mechanism involving activity of BKCa channels and L-arginine/NO pathway in endothelial cells.	Arginine	110-120	insulin	Homo sapiens	0-7
27814427-2	2016	We show that experimental CREBBP binding affinities of small-molecules with aromatic or heteroaromatic functional groups are strongly influenced by a cation-pi interaction with a positively charged arginine residue.	Arginine	198-206	CREB binding protein	Homo sapiens	26-32
27687728-6	2016	We found that the H684R substitution within human Abeta, which replaces the histidine in the human protein with the arginine found at the corresponding position in mouse, facilitated beta" cleavage irrespective of the species origin of BACE1, thereby significantly increasing the level of Abeta(11-XX) and decreasing the level of Abeta(1-XX).	Arginine	116-124	amyloid beta precursor protein	Homo sapiens	50-55
27717730-0	2016	L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation.	Arginine	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	121-124
27717730-0	2016	L-Arginine supplementation improves insulin sensitivity and beta cell function in the offspring of diabetic rats through AKT and PDX-1 activation.	Arginine	0-10	pancreatic and duodenal homeobox 1	Rattus norvegicus	129-134
27717730-5	2016	We observed that l-Arg improved insulin sensitivity in the offspring of diabetic mothers (DA), reflected by higher insulin-induced phosphorylation of Akt in muscle and adipose tissue.	Arginine	17-22	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
27717730-10	2016	In addition it is possible that l-Arg exerts its effects directly onto essential molecules for the maintenance and survival of pancreatic islets, decreasing protein expression of p47PHOX while increasing Akt phosphorylation and PDX-1 expression.	Arginine	32-37	AKT serine/threonine kinase 1	Rattus norvegicus	204-207
27717730-10	2016	In addition it is possible that l-Arg exerts its effects directly onto essential molecules for the maintenance and survival of pancreatic islets, decreasing protein expression of p47PHOX while increasing Akt phosphorylation and PDX-1 expression.	Arginine	32-37	pancreatic and duodenal homeobox 1	Rattus norvegicus	228-233
27697841-5	2016	In this work we show through N-terminal sequencing, pharmacologic studies, and mutational analysis that proprotein convertases (PCs) proteolytically process human Pxdn at Arg-1336, a location relatively close to its C terminus.	Arginine	171-174	peroxidasin	Homo sapiens	163-167
26567043-2	2016	We recently developed several potent hexapeptidic agonists derived from NMU that share a common Pro-Arg-Asn-NH2 (PRN) sequence at their C-termini and found that the amide bond between Arg and Asn is rapidly degraded in serum.	Arginine	100-103	neuromedin U	Homo sapiens	72-75
27744706-1	2016	This study describes an effective strategy to improve pharmacokinetics of Abeta imaging agents, offering a novel class of (R)- and (S)-18F-labeled 2-arylbenzoheterocyclic derivatives which bear an additional chiral hydroxyl group on the side chain.	Arginine	122-125	amyloid beta precursor protein	Homo sapiens	74-79
27867347-12	2016	Furthermore, seeding the aggregation of DTT/EDTA-treated SOD1G37R with preformed SOD1G93A fibrils elicited minimal aggregation response, suggesting that the arginine substitution at position-37 blocks the templating of SOD1 onto preformed fibrils.	Arginine	157-165	superoxide dismutase 1	Homo sapiens	57-61
27809896-4	2016	METHODS: We selected four HLA molecules (one HLA-DR and three HLA-DQ molecules) that could potentially prefer citrulline over arginine residues in specific pockets and in addition two HLA-SE alleles as a method validation control.	Arginine	126-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	45-48
27406711-2	2016	Arginase and nitric oxide synthase (NOS) both use L-arginine as a common substrate.	Arginine	50-60	nitric oxide synthase 2	Homo sapiens	13-34
27809896-4	2016	METHODS: We selected four HLA molecules (one HLA-DR and three HLA-DQ molecules) that could potentially prefer citrulline over arginine residues in specific pockets and in addition two HLA-SE alleles as a method validation control.	Arginine	126-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	45-48
27809896-4	2016	METHODS: We selected four HLA molecules (one HLA-DR and three HLA-DQ molecules) that could potentially prefer citrulline over arginine residues in specific pockets and in addition two HLA-SE alleles as a method validation control.	Arginine	126-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	45-48
27809896-6	2016	RESULTS: Pocket 4 of HLA-DRB1*04:04 and -DRB1*04:05 displayed a preference for citrulline over arginine, a property found in other pockets as well.	Arginine	95-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	21-29
27809896-6	2016	RESULTS: Pocket 4 of HLA-DRB1*04:04 and -DRB1*04:05 displayed a preference for citrulline over arginine, a property found in other pockets as well.	Arginine	95-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	25-29
27809896-8	2016	In contrast, several peptide-binding pockets of the analyzed HLA-DQ molecules showed enhanced affinities for citrulline compared to arginine residues: i.e., pockets 4, 6, 7, and 9 of HLA-DQ2 and pockets 1, 6, and 9 of HLA-DQ7 and HLA-DQ8.	Arginine	132-140	major histocompatibility complex, class II, DR beta 1	Homo sapiens	61-64
27809896-8	2016	In contrast, several peptide-binding pockets of the analyzed HLA-DQ molecules showed enhanced affinities for citrulline compared to arginine residues: i.e., pockets 4, 6, 7, and 9 of HLA-DQ2 and pockets 1, 6, and 9 of HLA-DQ7 and HLA-DQ8.	Arginine	132-140	major histocompatibility complex, class II, DR beta 1	Homo sapiens	183-186
27809896-8	2016	In contrast, several peptide-binding pockets of the analyzed HLA-DQ molecules showed enhanced affinities for citrulline compared to arginine residues: i.e., pockets 4, 6, 7, and 9 of HLA-DQ2 and pockets 1, 6, and 9 of HLA-DQ7 and HLA-DQ8.	Arginine	132-140	major histocompatibility complex, class II, DR beta 1	Homo sapiens	183-186
27809896-8	2016	In contrast, several peptide-binding pockets of the analyzed HLA-DQ molecules showed enhanced affinities for citrulline compared to arginine residues: i.e., pockets 4, 6, 7, and 9 of HLA-DQ2 and pockets 1, 6, and 9 of HLA-DQ7 and HLA-DQ8.	Arginine	132-140	major histocompatibility complex, class II, DR beta 1	Homo sapiens	183-186
27809896-9	2016	CONCLUSIONS: Arginine-to-citrulline conversion of peptides can also enhance the binding affinity for non-HLA-SE molecules.	Arginine	13-21	major histocompatibility complex, class II, DR beta 1	Homo sapiens	105-108
27706921-8	2016	The bottom-up analysis also showed that the NESP biosimilars, as well as a rEPO biosimilar, contain not only the des-arginine product but also the C-terminal arginine product comprising 166 amino acids, whereas the innovator products contain des-arginine EPO comprising only 165 amino acids.	Arginine	117-125	GNAS complex locus	Homo sapiens	44-48
27706921-9	2016	The C-terminal arginine EPO would be used as a potential marker for doping with EPO bisimilaras.	Arginine	15-23	erythropoietin	Homo sapiens	24-27
27706921-9	2016	The C-terminal arginine EPO would be used as a potential marker for doping with EPO bisimilaras.	Arginine	15-23	erythropoietin	Homo sapiens	80-83
26979994-8	2016	The results showed that silymarin and L-Arg macroscopically and microscopically ameliorated TNBS-induced colitis; significantly decreased the serum levels of TNF-alpha; inhibited the colonic expression of iNOS, NF-kappaB, and cytochrome c; and increased expression of HSP70.	Arginine	38-43	tumor necrosis factor	Rattus norvegicus	158-167
26979994-8	2016	The results showed that silymarin and L-Arg macroscopically and microscopically ameliorated TNBS-induced colitis; significantly decreased the serum levels of TNF-alpha; inhibited the colonic expression of iNOS, NF-kappaB, and cytochrome c; and increased expression of HSP70.	Arginine	38-43	nitric oxide synthase 2	Rattus norvegicus	205-209
27809896-0	2016	The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules.	Arginine	91-99	major histocompatibility complex, class II, DR beta 1	Homo sapiens	160-163
27809896-3	2016	To better understand the HLA-RA connection, we aimed to investigate if the enhanced capacity to present arginine-to-citrulline-converted peptides is unique for HLA-SE alleles.	Arginine	104-112	major histocompatibility complex, class II, DR beta 1	Homo sapiens	25-28
27809896-3	2016	To better understand the HLA-RA connection, we aimed to investigate if the enhanced capacity to present arginine-to-citrulline-converted peptides is unique for HLA-SE alleles.	Arginine	104-112	major histocompatibility complex, class II, DR beta 1	Homo sapiens	160-163
27809896-4	2016	METHODS: We selected four HLA molecules (one HLA-DR and three HLA-DQ molecules) that could potentially prefer citrulline over arginine residues in specific pockets and in addition two HLA-SE alleles as a method validation control.	Arginine	126-134	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-29
27593239-7	2016	This was accompanied by the improvement/restitution of eNOS and HO1 or MnSOD and GSH-Px protein expression levels in diabetic skin following L-arginine, i.e. SOD mimic treatments, respectively.	Arginine	141-151	glutathione peroxidase 1	Rattus norvegicus	81-87
27636828-9	2016	This mutation substitutes a highly conserved glutamic to arginine at the position of the 47th amino acid which was shown to be located on the flank of the pleated sheet domain in PATE1 protein by the 3D model given by the Protein Model Portal (PMP).	Arginine	57-65	prostate and testis expressed 1	Homo sapiens	179-184
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Arginine	56-64	androgen receptor	Homo sapiens	3-5
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Arginine	56-64	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Arginine	56-64	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Arginine	56-64	androgen receptor	Homo sapiens	66-68
27659526-6	2016	An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, and xenograft tumor formation due to attenuation of AR nuclear translocation, whereas, construct mimicking neutral polar substitution acetylation at K618 by glutamine (AR-618Q) enhanced these effects beyond that of the wild-type AR.	Arginine	56-64	androgen receptor	Homo sapiens	66-68
27710858-0	2016	Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen.	Arginine	31-34	fibrinogen beta chain	Homo sapiens	6-9
27895230-1	2016	Arginase and nitric oxide synthase (NOS) share a common substrate, l-arginine, and have opposing effects on vascular remodeling.	Arginine	67-77	nitric oxide synthase 2	Homo sapiens	13-34
27710858-0	2016	Novel FGB mutation Bbeta240Cys Arg confirms importance of the Bbeta211-240 disulphide for plasma expression of fibrinogen.	Arginine	31-34	fibrinogen beta chain	Homo sapiens	111-121
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	33-41	T cell receptor alpha variable 20	Homo sapiens	83-89
27593859-0	2016	Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation.	Arginine	79-89	nitric oxide synthase 3	Homo sapiens	100-133
27593859-8	2016	The decreased eNOS phosphorylation at Ser1177 and the increased at Thr495 by SIN-1 were restored with arginase inhibitor and L-arginine.	Arginine	125-135	nitric oxide synthase 3	Homo sapiens	14-18
27593859-8	2016	The decreased eNOS phosphorylation at Ser1177 and the increased at Thr495 by SIN-1 were restored with arginase inhibitor and L-arginine.	Arginine	125-135	MAPK associated protein 1	Homo sapiens	77-82
27593859-10	2016	SIN-1 decreased NO production and increased ROS generation in the aortic endothelium, all of which was reversed by arginase inhibitor or L-arginine.	Arginine	137-147	MAPK associated protein 1	Homo sapiens	0-5
27561318-1	2016	Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.	Arginine	228-231	coagulation factor II, thrombin	Homo sapiens	84-92
27363479-11	2016	We thus established a production process for high-purity recombinant human glargine insulin and a method to block Arg (B31)-insulin formation.	Arginine	114-117	insulin	Homo sapiens	124-131
27782840-5	2016	In particular, ICln regulates MyoD expression via its interaction with PRMT5 by an epigenetic modification that utilizes symmetrical di-methylation of histone H3 on arginine 8.	Arginine	165-173	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	15-19
27776129-7	2016	Methylation-deficient mutation of Scd6 suppressed the phenotypic defects of scd6 dhh1 double mutant, whereas methylation-mimic mutation did not, suggesting that the arginine methylation might negatively regulate Scd6 function relating to Dhh1.	Arginine	165-173	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	81-85
27776129-7	2016	Methylation-deficient mutation of Scd6 suppressed the phenotypic defects of scd6 dhh1 double mutant, whereas methylation-mimic mutation did not, suggesting that the arginine methylation might negatively regulate Scd6 function relating to Dhh1.	Arginine	165-173	DExD/H-box ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae S288C	238-242
27745970-5	2016	Proteome-wide probing of structural alterations, validated by the analysis of knockout T cell clones, identified three transcriptional regulators (BAZ1B, PSIP1, and TSN) that sensed L-arginine levels and promoted T cell survival.	Arginine	182-192	bromodomain adjacent to zinc finger domain 1B	Homo sapiens	147-152
27561318-1	2016	Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.	Arginine	228-231	coagulation factor II thrombin receptor	Homo sapiens	14-43
27561318-1	2016	Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.	Arginine	228-231	coagulation factor II thrombin receptor	Homo sapiens	45-49
27649793-3	2016	Egg white ovotransferrin-derived tripeptide IRW (Ile-Arg-Trp) was previously shown to exert antihypertensive effect by reducing Ang II synthesis as well as endothelial cell inflammation and endothelial dysfunction.	Arginine	53-56	angiotensinogen	Homo sapiens	128-134
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	148-156	T cell receptor alpha variable 20	Homo sapiens	83-89
27927271-9	2016	In addition, the lnc-ARG located within the upstream of ALOX5 was sorted as a noncoding transcript by analyzing the protein-coding potential using computational analysis.	Arginine	21-24	arachidonate 5-lipoxygenase	Homo sapiens	56-61
27643437-9	2016	This study suggests that epigenetic methylation modification on histone protein arginine residues is a regulatory mechanism to control self-renewal of LSCs and indicates that PRMT5 may represent a potential therapeutic target against LSCs.	Arginine	80-88	protein arginine methyltransferase 5	Homo sapiens	175-180
27480107-0	2016	Structural basis of arginine asymmetrical dimethylation by PRMT6.	Arginine	20-28	protein arginine methyltransferase 6	Homo sapiens	59-64
27927271-10	2016	Furthermore, we found that lnc-ARG can decrease the mRNA level of ALOX5 and reactive oxygen species production in HeLa cells.	Arginine	31-34	arachidonate 5-lipoxygenase	Homo sapiens	66-71
27426075-9	2016	DMSO significantly increased the abundance of phosphorylated CAT-1 (the inactive form) and phosphorylated PKC-alpha protein, an effect that was attenuated by l-arginine.	Arginine	158-168	protein kinase C alpha	Homo sapiens	106-115
27426075-10	2016	GO 6976 (PKC-alpha antagonist) prevented the decrease in arginine transport caused by DMSO.	Arginine	57-65	protein kinase C alpha	Homo sapiens	9-18
27392809-4	2016	Reduction of arginine conversion was best obtained by adding 5 mM l-ornithine, followed by 3.5 mM l-proline and by lowering the arginine concentration in the medium to 99.5 muM.	Arginine	128-136	latexin	Homo sapiens	173-176
27385642-7	2016	Mutation of arginine 286 to alanine impairs dimer formation, interaction with COP1 and function in vivo, whereas mutation to lysine gives a weakened dimer that is functional in vivo, indicating the importance of the positive charge of the arginine/lysine residue for dimer formation.	Arginine	12-20	COP1 E3 ubiquitin ligase	Homo sapiens	78-82
27300576-1	2016	CONTEXT: Recently, an arginine-to-cysteine homozygous mutation at position 25 in mature PTH was reported in a Korean patient with hypoparathyroidism.	Arginine	22-30	parathyroid hormone	Homo sapiens	88-91
27392809-4	2016	Reduction of arginine conversion was best obtained by adding 5 mM l-ornithine, followed by 3.5 mM l-proline and by lowering the arginine concentration in the medium to 99.5 muM.	Arginine	13-21	latexin	Homo sapiens	173-176
27510035-1	2016	Nalpha-terminal arginylation (Nt-arginylation) of proteins is mediated by the Ate1 arginyltransferase (R-transferase), a component of the Arg/N-end rule pathway.	Arginine	138-141	arginyltransferase 1	Mus musculus	78-82
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Arginine	103-106	cytochrome p450 oxidoreductase	Homo sapiens	27-30
27583975-7	2016	Modulation of water permeation may occur as a result of rearrangement of side chains from loop C in the extracellular vestibule of hAQP1, affecting the aromatic arginine selectivity filter.	Arginine	161-169	aquaporin 1 (Colton blood group)	Homo sapiens	131-136
27641898-7	2016	A previously unrecognized arginine-rich motif in Dysf is crucial for PS accumulation.	Arginine	26-34	dysferlin	Homo sapiens	49-53
27461959-1	2016	Cytochrome P450 reductase (CPR) contains a loop within the active site (comprising Asp(634), Ala(635), Arg(636) and Asn(637); human CPR numbering) that relocates upon NADPH binding.	Arginine	103-106	cytochrome p450 oxidoreductase	Homo sapiens	0-25
27533248-2	2016	P45 is a hybrid peptide composed of an Arg-Gly-Asp motif linked to the human matrilin-1 C-terminal domain by a serine linker.	Arginine	39-42	nuclear factor, erythroid 2	Homo sapiens	0-3
27288240-3	2016	This permeability, which increases neuronal excitability, is due to the lack of the GluA2 subunit, encoded by the GRIA2A gene, and/or the presence of an unedited GluA2 subunit Q/R site (glutamine instead of arginine).	Arginine	207-215	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	162-167
27737343-0	2016	Oral or topical administration of L-arginine changes the expression of TGF and iNOS and results in early wounds healing.	Arginine	34-44	nitric oxide synthase 2, inducible	Mus musculus	79-83
27407117-6	2016	In the AST, insulin secretory response to arginine at basal glucose and during hyperglycemia was lower in T2DM compared with NGT and PDM (&gt;58%; all P &lt; 0.001).	Arginine	42-50	insulin	Homo sapiens	12-19
28139534-1	2016	BACKGROUND &amp; OBJECTIVES: The Arg&gt;Pro polymorphism in codon 72 of p53 gene is known to affect the susceptibility of cervical cancer differently in different population worldwide although information regarding its role in determining survival status and disease outcome in patients is lacking.	Arginine	33-36	tumor protein p53	Homo sapiens	72-75
28139534-2	2016	The present study was conducted to determine the genotype frequency and prognostic role of p53 codon 72 Arg&gt;Pro polymorphism in patients with advanced stage cervical cancer in India.	Arginine	104-107	tumor protein p53	Homo sapiens	91-94
27121159-3	2016	We tested the hypothesis that aerobic training and l-arginine supplementation promotes cardiac and skeletal muscles arteriogenesis after myocardial infarction (MI) parallel to upregulation of TGF-beta and downregulation of angiostatin.	Arginine	51-61	transforming growth factor, beta 1	Rattus norvegicus	192-200
27121159-9	2016	Aerobic training and l-arginine increased the number of cardiac arterioles with 11-25 and 26-50 mum diameters parallel to TGF-beta overexpression.	Arginine	21-31	transforming growth factor, beta 1	Rattus norvegicus	122-130
27121159-12	2016	Results showed that 10 weeks aerobic exercise training and l-arginine supplementation promotes arteriogenesis of heart and gastrocnemius muscles parallel to overexpression of TGF-beta and downregulation of angiostatin in MI rats.	Arginine	59-69	transforming growth factor, beta 1	Rattus norvegicus	175-183
26923761-1	2016	In inflammatory arthritis peptidyl arginine deiminase (PAD) enzymes can citrullinate arginine residues in extracellular matrix (ECM) proteins, such as collagens and fibronectin.	Arginine	35-43	fibronectin 1	Homo sapiens	165-176
27507154-8	2016	Intracellular arginine was increased by 18.9% or 13.1% respectively by overexpression of ARG4 or disruption of CAR1, which enhanced yeast tolerance to ethanol stress.	Arginine	14-22	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	89-93
27297094-6	2016	Inhibition of ubiquitin-activating enzyme E1 by PYR-41 or blocking the formation of ubiquitin chains by over-expressing the lysine to arginine mutation of ubiquitin K48 (K48R) inhibited A3G degradation.	Arginine	134-142	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	186-189
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Arginine	84-87	epidermal growth factor receptor	Homo sapiens	18-22
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Arginine	88-91	epidermal growth factor receptor	Homo sapiens	18-22
27601918-11	2016	The expression of EGFR was higher in patients with genotypes of -216T/T or -216G/T, Arg/Arg or Arg/Lys, and shorter CA-SSR1 (&lt;17) than that in patients with genotypes of -216G/G, Lys/Lys, and longer CA-SSR1 (&gt;=17), respectively.	Arginine	88-91	epidermal growth factor receptor	Homo sapiens	18-22
27358479-0	2016	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	Arginine	42-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
27358479-0	2016	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	Arginine	42-45	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	21-24
27358479-0	2016	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	Arginine	42-45	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	29-32
27358479-8	2016	Src-mediated Arg activation is required for efficient uptake.	Arginine	13-16	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
27470910-7	2016	In the ARG, the osteoblasts viability, TGF-beta1, BMP-2, IGF-I and Cbfalpha1 mRNA expressions and the GSH-Px and SOD activities were significantly increased, the ROS concentration was significantly decreased, and osteoblasts histology lesion was attenuated compared with the AG.	Arginine	7-10	transforming growth factor, beta 1	Rattus norvegicus	39-48
27470910-7	2016	In the ARG, the osteoblasts viability, TGF-beta1, BMP-2, IGF-I and Cbfalpha1 mRNA expressions and the GSH-Px and SOD activities were significantly increased, the ROS concentration was significantly decreased, and osteoblasts histology lesion was attenuated compared with the AG.	Arginine	7-10	RUNX family transcription factor 2	Rattus norvegicus	67-76
27179212-6	2016	The VO2max was significantly higher and the maximal DBP was significantly lower in the ARG than in the NRG (p&lt;0.05).	Arginine	87-90	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
27247266-7	2016	Depletion of PRMT5, the primary protein arginine methyltransferase responsible for symmetric arginine dimethylation, including Lsm4, resulted in loss of PBs.	Arginine	40-48	protein arginine methyltransferase 5	Homo sapiens	13-18
27480244-1	2016	BACKGROUND: Protein arginine methyltransferase 5 (PRMT5) catalyzes the formation of symmetrical dimethylation of arginine residues in proteins.	Arginine	20-28	protein arginine methyltransferase 5	Homo sapiens	50-55
27498764-6	2016	We observed a significant decrease in the NOS substrate l-arginine in plasma from CRPS patients, suggesting reduced miR-939 levels may contribute to an increase in endogenous NOS2A levels and NO, and thereby to pain and inflammation.	Arginine	56-66	microRNA 939	Homo sapiens	116-123
27498764-6	2016	We observed a significant decrease in the NOS substrate l-arginine in plasma from CRPS patients, suggesting reduced miR-939 levels may contribute to an increase in endogenous NOS2A levels and NO, and thereby to pain and inflammation.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	175-180
27183873-0	2016	Methylation of arginine by PRMT1 regulates Nrf2 transcriptional activity during the antioxidative response.	Arginine	15-23	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
27183873-4	2016	Here we demonstrate that the arginine methyltransferase-1 (PRMT1) methylates Nrf2 protein at a single residue of arginine 437, both in vitro and in vivo.	Arginine	29-37	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
27298228-7	2016	A further TGF-beta1 increase was induced by Arg silencing with siRNA, as with the Arg tyrosine kinase inhibitor Imatinib.	Arginine	44-47	transforming growth factor beta 1	Homo sapiens	10-19
27345715-1	2016	The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals.	Arginine	136-139	arginyltransferase 1	Mus musculus	143-147
27312592-8	2016	We found that the amylolytic activity of Amyrel is about thirty times weaker than the classical Drosophila alpha-amylase, and that the substitution of the arginine by a glutamine in D. melanogaster suppressed the chloride-dependence but was detrimental to activity.	Arginine	155-163	amyrel	Drosophila melanogaster	41-47
27277835-1	2016	Arginine-specific ADP-ribosytransferases 1 (ART1) is able to modify the arginine of specific proteins by mono-ADP-ribosylation.	Arginine	72-80	ADP-ribosyltransferase 1	Mus musculus	44-48
29894073-12	2016	They may therefore, conclude that detection of allelic polymorphisms of codon 72 of the p53 gene including arginine/arginine could be a risk factor predisposition for breast cancer and valuable tool for determining prognosis, progress, and treatment purposes.	Arginine	107-115	tumor protein p53	Homo sapiens	88-91
29894073-12	2016	They may therefore, conclude that detection of allelic polymorphisms of codon 72 of the p53 gene including arginine/arginine could be a risk factor predisposition for breast cancer and valuable tool for determining prognosis, progress, and treatment purposes.	Arginine	116-124	tumor protein p53	Homo sapiens	88-91
27263035-9	2016	Strong negative correlation was found between IL-6 and L-arginine levels in the hyperacute phase in patients with poststroke infection.	Arginine	55-65	interleukin 6	Homo sapiens	46-50
27063995-10	2016	A significant redundant interaction between IL1B +3954 C/T and FCGR2A 131His/Arg was observed.	Arginine	77-80	interleukin 1 beta	Homo sapiens	44-48
27466704-4	2016	Methylation of KCNQ2 channels at 4 arginine residues by Prmt1 enhances PIP2 binding, and Prmt1 depletion lowers PIP2 affinity of KCNQ2 channels and thereby the channel activities.	Arginine	35-43	potassium voltage-gated channel, subfamily Q, member 2	Mus musculus	15-20
27104830-1	2016	BACKGROUND: L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzymes.	Arginine	12-22	nitric oxide synthase 2	Homo sapiens	95-99
27104830-1	2016	BACKGROUND: L-arginine (L-Arg) is the substrate for both inducible nitric oxide (NO) synthase (NOS2) and arginase (ARG) enzymes.	Arginine	24-29	nitric oxide synthase 2	Homo sapiens	95-99
27104830-16	2016	CONCLUSIONS: Patients with UC exhibit diminished tissue L-Arg, likely attributable to decreased cellular uptake and increased consumption by NOS2.	Arginine	56-61	nitric oxide synthase 2	Homo sapiens	141-145
27226634-9	2016	However, similar to another family member, RdmB, it catalyzes the introduction of a hydroxyl group, in the case of NDUFAF5, into Arg-73 in the NDUFS7 subunit of human complex I.	Arginine	129-132	NADH:ubiquinone oxidoreductase complex assembly factor 5	Homo sapiens	115-122
27512387-7	2016	identified two distinct gsp somatic mutations affecting arginine residues on codon 201 of GNAS in a few patients with PMAH who lacked any features or manifestations of MAS.	Arginine	56-64	GNAS complex locus	Homo sapiens	24-27
27512387-7	2016	identified two distinct gsp somatic mutations affecting arginine residues on codon 201 of GNAS in a few patients with PMAH who lacked any features or manifestations of MAS.	Arginine	56-64	GNAS complex locus	Homo sapiens	90-94
27432473-8	2016	Collectively, we provide novel evidence that activation of CB2Rs eliminates ACh-induced Ca(2+) oscillations and L-arginine-induced enhancement of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechanism of CB2R-mediated protection in acute pancreatitis.	Arginine	112-122	cannabinoid receptor 2 (macrophage)	Mus musculus	59-62
27432473-8	2016	Collectively, we provide novel evidence that activation of CB2Rs eliminates ACh-induced Ca(2+) oscillations and L-arginine-induced enhancement of Ca(2+) signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechanism of CB2R-mediated protection in acute pancreatitis.	Arginine	112-122	cannabinoid receptor 2 (macrophage)	Mus musculus	59-63
27287681-9	2016	SIGNIFICANCE: Exogenous l-arginine diminished metalloproteinase-2 and -9 activities and MMP-9/TIMP-1 ratio along with restoring the oxidative stress balance in patients with hypertension.	Arginine	24-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	94-100
27335408-0	2016	Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice.	Arginine	144-147	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	Mus musculus	139-143
27174096-7	2016	Two structural features are responsible for apoE4 dysfunction: domain interaction, in which arginine-61 interacts ionically with glutamic acid-255, and a less stable conformation than apoE3 and apoE2.	Arginine	92-100	apolipoprotein E	Homo sapiens	44-49
27061807-3	2016	At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were modified.	Arginine	42-45	heat shock protein family B (small) member 6	Homo sapiens	12-17
27061807-3	2016	At high MGO/HspB6 ratio, practically, all Arg and Lys residues of HspB6 were modified.	Arginine	42-45	heat shock protein family B (small) member 6	Homo sapiens	66-71
27061807-9	2016	It is concluded that Arg residues located in the N-terminal domain of HspB6 are easily accessible to MGO modification and that even mild modification by MGO affects susceptibility to trypsinolysis, phosphorylation by cAMP-dependent protein kinase, and chaperone-like activity of HspB6.	Arginine	21-24	heat shock protein family B (small) member 6	Homo sapiens	70-75
27061807-9	2016	It is concluded that Arg residues located in the N-terminal domain of HspB6 are easily accessible to MGO modification and that even mild modification by MGO affects susceptibility to trypsinolysis, phosphorylation by cAMP-dependent protein kinase, and chaperone-like activity of HspB6.	Arginine	21-24	heat shock protein family B (small) member 6	Homo sapiens	279-284
26508575-6	2016	NOS3 is highly expressed in the central nervous system (including cerebellum), neurons and endothelial cells, and is one of three enzymes that converts l-arginine to the neurotransmitter NO.	Arginine	152-162	nitric oxide synthase 3	Homo sapiens	0-4
27214549-1	2016	High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma.	Arginine	15-23	nitric oxide synthase 2, inducible	Mus musculus	56-87
27214549-1	2016	High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma.	Arginine	15-23	nitric oxide synthase 2, inducible	Mus musculus	89-93
27214549-1	2016	High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma.	Arginine	224-232	nitric oxide synthase 2, inducible	Mus musculus	89-93
27296367-5	2016	In this study, we mutate this arginine to a histidine in the human glutamate transporter EAAT1 and investigate the role of the protonation state of this residue on anion selectivity and transporter function.	Arginine	30-38	solute carrier family 1 member 3	Homo sapiens	89-94
27355158-6	2021	The mean GH peak after L-arginine stimulation was 2.9 +- 2.9 ng/ml.	Arginine	23-33	growth hormone 1	Homo sapiens	9-11
27417628-1	2016	The arginine metabolite asymmetric dimethylarginine (ADMA) is a competitive inhibitor and uncoupler of endothelial nitric oxide synthase (eNOS), an enzyme that acts in multifarious ways to promote cardiovascular health.	Arginine	4-12	nitric oxide synthase 3	Homo sapiens	103-136
27417628-1	2016	The arginine metabolite asymmetric dimethylarginine (ADMA) is a competitive inhibitor and uncoupler of endothelial nitric oxide synthase (eNOS), an enzyme that acts in multifarious ways to promote cardiovascular health.	Arginine	4-12	nitric oxide synthase 3	Homo sapiens	138-142
27417628-3	2016	Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental citrulline.	Arginine	103-111	nitric oxide synthase 3	Homo sapiens	47-51
27084712-5	2016	When the fibronectin peptide reacted with methylglyoxal, modifications occurred at lysine and arginine residues.	Arginine	94-102	fibronectin 1	Homo sapiens	9-20
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Arginine	28-36	reticulon 4 receptor	Mus musculus	4-7
27332127-6	2016	The substitution of hydrophobic Ala with His or Arg in the central region of the EDEM1 or SPAST peptides, respectively, attenuated their ability to flip phospholipids.	Arginine	48-51	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	81-86
27332127-9	2016	The EDEM1 peptide exhibited high activity at significantly low peptide concentrations, suggesting that the same side positioning of Arg and His in alpha-helix structure is critical for the flip-flop promotion and that the EDEM1 protein is a candidate flippase in the ER.	Arginine	132-135	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	4-9
27284014-8	2016	The functional PI3K/Akt signaling is tightly responsive to FOXO3a activation alongside doxorubicin treatment, which directs FOXO3a arginine hypermethylation.	Arginine	131-139	AKT serine/threonine kinase 1	Homo sapiens	20-23
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	calmodulin 1	Homo sapiens	216-219
27275094-1	2016	AIM: To investigate the potential protective effect of exogenous recombinant interleukin-22 (rIL-22) on L-arginine-induced acute severe pancreatitis (SAP)-associated lung injury and the possible signaling pathway involved.	Arginine	104-114	interleukin 22	Rattus norvegicus	93-99
27129265-6	2016	Significant stabilization of anionic trypsinogen against degradation was achieved by simultaneous mutations of CTRC cleavage sites Leu-81 and Leu-148, autolytic cleavage site Arg-122, and restoration of the missing disulfide bridge.	Arginine	175-178	serine protease 2	Homo sapiens	29-48
27153778-0	2016	Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization.	Arginine	54-62	aryl-hydrocarbon receptor	Mus musculus	0-25
27214780-5	2016	In addition to a phosphonate warhead, these dipeptides possess two benzguanidine moieties as arginine mimetics to provide affinity for matriptase-2 by binding to the S1 and S3/S4 subpockets, respectively.	Arginine	93-101	transmembrane serine protease 6	Homo sapiens	135-147
27284014-8	2016	The functional PI3K/Akt signaling is tightly responsive to FOXO3a activation alongside doxorubicin treatment, which directs FOXO3a arginine hypermethylation.	Arginine	131-139	forkhead box O3	Homo sapiens	59-65
27284014-8	2016	The functional PI3K/Akt signaling is tightly responsive to FOXO3a activation alongside doxorubicin treatment, which directs FOXO3a arginine hypermethylation.	Arginine	131-139	forkhead box O3	Homo sapiens	124-130
27275094-16	2016	CONCLUSION: Exogenous recombinant IL-22 protects mice against L-arginine-induced SAP-associated lung injury by enhancing the expression of anti-apoptosis genes through the STAT3 signaling pathway.	Arginine	62-72	signal transducer and activator of transcription 3	Mus musculus	172-177
27210019-4	2016	By changing lysines 351 and 357 to arginine, thereby blocking all post-translational modifications of these residues, DNA binding and transcriptional regulation by p53 remain virtually unchanged.	Arginine	35-43	tumor protein p53	Homo sapiens	164-167
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Arginine	67-75	Avt1p	Saccharomyces cerevisiae S288C	9-13
27304453-10	2016	The results revealed that (1) homozygosity of the Pro72 variant of p53 was present in 26 laryngeal carcinoma patients (65%), (2) heterozygosity for the Pro/Arg genotype was present in 13 patients (32.5%), and (3) the Arg72 variant of the p53 allele was present in 1 patient (2.5%) before treatment.	Arginine	156-159	tumor protein p53	Homo sapiens	67-70
27246354-2	2016	In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs).	Arginine	27-32	nitric oxide synthase 2	Homo sapiens	48-71
27246354-2	2016	In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs).	Arginine	27-32	nitric oxide synthase 2	Homo sapiens	73-77
27173462-8	2016	The acute insulin response was greater with two or more metabolic syndrome components, and late glucose-stimulated and L-arginine-stimulated insulin responses exhibited a similar trend.	Arginine	119-129	insulin	Homo sapiens	141-148
26212097-7	2016	Prima facie, the comparative molecular dynamics study, over total 500 ns, identifies Arg(74)-Tyr(23) and Arg(37)-Phe(51) "cation-pi" pairs as the molecular "allosteric switches" on (h)C5a that potentially functions as a damper of C5aR signaling.	Arginine	85-88	complement C5a receptor 1	Homo sapiens	184-187
26212097-7	2016	Prima facie, the comparative molecular dynamics study, over total 500 ns, identifies Arg(74)-Tyr(23) and Arg(37)-Phe(51) "cation-pi" pairs as the molecular "allosteric switches" on (h)C5a that potentially functions as a damper of C5aR signaling.	Arginine	85-88	complement C5a receptor 1	Homo sapiens	230-234
26212097-7	2016	Prima facie, the comparative molecular dynamics study, over total 500 ns, identifies Arg(74)-Tyr(23) and Arg(37)-Phe(51) "cation-pi" pairs as the molecular "allosteric switches" on (h)C5a that potentially functions as a damper of C5aR signaling.	Arginine	105-108	complement C5a receptor 1	Homo sapiens	184-187
26212097-7	2016	Prima facie, the comparative molecular dynamics study, over total 500 ns, identifies Arg(74)-Tyr(23) and Arg(37)-Phe(51) "cation-pi" pairs as the molecular "allosteric switches" on (h)C5a that potentially functions as a damper of C5aR signaling.	Arginine	105-108	complement C5a receptor 1	Homo sapiens	230-234
27376811-2	2016	The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA).	Arginine	19-27	tumor protein p53	Homo sapiens	106-109
27376811-2	2016	The change from an arginine (Arg) to a proline (Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion (RSA).	Arginine	29-32	tumor protein p53	Homo sapiens	106-109
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Arginine	117-120	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Arginine	121-124	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Arginine	121-124	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Arginine	121-124	tumor protein p53	Homo sapiens	44-47
27376811-7	2016	There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model (Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14-2.24) and co-dominant model (Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02-2.12) whether the study that was deviated from HWE was eliminated or not.	Arginine	121-124	tumor protein p53	Homo sapiens	44-47
26724939-6	2016	Lastly, we proved that the (78)Arg-Ser-Ser motif of porcine TNFalpha contained the essential information for efficient cleavage.	Arginine	31-34	tumor necrosis factor	Homo sapiens	60-68
26876596-3	2016	Here, we report on the cooperative effect of Tet2 inactivation and DNMT3A mutation affecting arginine 882 (DNMT3A(R882H)) using a murine bone marrow transplantation assay.	Arginine	93-101	DNA methyltransferase 3A	Mus musculus	67-73
26876596-3	2016	Here, we report on the cooperative effect of Tet2 inactivation and DNMT3A mutation affecting arginine 882 (DNMT3A(R882H)) using a murine bone marrow transplantation assay.	Arginine	93-101	DNA methyltransferase 3A	Mus musculus	107-113
27156372-7	2016	l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p&lt;0.001 in each case).	Arginine	0-10	solute carrier family 17 member 5	Homo sapiens	56-59
27126696-9	2016	This work also provides the first direct evidence of (1) intracellular cleavage at the Arg(1648) FVIII processing site promoted by wild-type PACE and PCSK7 and (2) proteolytic processing at the Arg(1648) FVIII processing site by PCSK6.	Arginine	87-90	proprotein convertase subtilisin/kexin type 7	Homo sapiens	150-155
27156372-7	2016	l-Arginine caused greater percent reductions in ALT and AST in SCA subjects but greater percent reduction in ALP in NSCA subjects (p&lt;0.001 in each case).	Arginine	0-10	alkaline phosphatase, placental	Homo sapiens	109-112
27025389-0	2016	Arginine Supplementation Recovered the IFN-gamma-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2alpha Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells.	Arginine	0-8	interferon gamma	Homo sapiens	39-48
27221710-4	2016	We found that synthetic monomeric Abeta40 bound through its RHDS (Arg-His-Asp-Ser) sequence to integrin alphaIIbbeta3, which is the receptor for the extracellular matrix protein fibrinogen, and stimulated the secretion of adenosine diphosphate (ADP) and the chaperone protein clusterin from platelets.	Arginine	66-69	fibrinogen beta chain	Homo sapiens	178-188
27116363-0	2016	Time Resolved EPR Study on the Photoinduced Long-Range Charge-Separated State in Protein: Electron Tunneling Mediated by Arginine Residue in Human Serum Albumin.	Arginine	121-129	albumin	Homo sapiens	147-160
26826314-3	2016	Arginine and urea are both used to assist in proinsulin refolding, however the efficacy and possible mechanism was found to be different.	Arginine	0-8	insulin	Homo sapiens	45-55
27226058-1	2016	The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRgamma, which differs by a single arginine within the DNA binding domain.	Arginine	156-164	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-27
27226058-1	2016	The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRgamma, which differs by a single arginine within the DNA binding domain.	Arginine	156-164	nuclear receptor subfamily 3 group C member 1	Homo sapiens	29-31
27025389-0	2016	Arginine Supplementation Recovered the IFN-gamma-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2alpha Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells.	Arginine	0-8	casein beta	Bos taurus	70-82
27159678-0	2016	Association of p53 codon72 Arg&gt;Pro polymorphism with susceptibility to nasopharyngeal carcinoma: evidence from a case-control study and meta-analysis.	Arginine	27-30	tumor protein p53	Homo sapiens	15-18
27183006-3	2016	ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761.	Arginine	68-76	ETS transcription factor ERG	Homo sapiens	0-3
27183006-3	2016	ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761.	Arginine	68-76	protein arginine methyltransferase 5	Homo sapiens	13-18
27183006-3	2016	ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761.	Arginine	68-76	androgen receptor	Homo sapiens	22-24
27183006-3	2016	ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761.	Arginine	68-76	protein arginine methyltransferase 5	Homo sapiens	45-50
27183006-3	2016	ERG recruits PRMT5 to AR-target genes, where PRMT5 methylates AR on arginine 761.	Arginine	68-76	androgen receptor	Homo sapiens	62-64
27183006-8	2016	Moreover, methylation of AR at arginine 761 highlights a mechanism for how the ERG oncogene may coax AR towards inducing proliferation versus differentiation.	Arginine	31-39	androgen receptor	Homo sapiens	25-27
27183006-8	2016	Moreover, methylation of AR at arginine 761 highlights a mechanism for how the ERG oncogene may coax AR towards inducing proliferation versus differentiation.	Arginine	31-39	ETS transcription factor ERG	Homo sapiens	79-82
27183006-8	2016	Moreover, methylation of AR at arginine 761 highlights a mechanism for how the ERG oncogene may coax AR towards inducing proliferation versus differentiation.	Arginine	31-39	androgen receptor	Homo sapiens	101-103
27045109-6	2016	RAGE or absent in melanoma 2 depletion in mice limited tissue injury, reduced systemic inflammation, and protected against AP induced by l-arginine or cerulein in experimental animal models.	Arginine	137-147	advanced glycosylation end product-specific receptor	Mus musculus	0-4
27109002-11	2016	Relative to those of the diquat group, higher CAT activity and GSH content were noted in the plasma of the DT + ARG group and in the liver of both DT + ARG and DT + NCG groups (P &lt; 0.05).	Arginine	112-115	catalase	Rattus norvegicus	46-49
27109002-11	2016	Relative to those of the diquat group, higher CAT activity and GSH content were noted in the plasma of the DT + ARG group and in the liver of both DT + ARG and DT + NCG groups (P &lt; 0.05).	Arginine	152-155	catalase	Rattus norvegicus	46-49
27159678-3	2016	Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC).	Arginine	102-110	tumor protein p53	Homo sapiens	34-37
27159678-3	2016	Single-nucleotide polymorphism of p53 at codon72 leading to substitution of proline (Pro) in place of arginine (Arg) has been identified as a risk factor for development of many cancers, including nasopharyngeal carcinoma (NPC).	Arginine	112-115	tumor protein p53	Homo sapiens	34-37
27159678-5	2016	We aimed to conduct a case-control study for a possible relation of p53 codon72 Arg&gt;Pro polymorphism with NPC risk in underdeveloped states of India, combine the result with previously available records from different databases and perform a meta-analysis to draw a more definitive conclusion.	Arginine	80-83	tumor protein p53	Homo sapiens	68-71
27159678-7	2016	The p53 codon72 Arg&gt;Pro polymorphism was typed by polymerase chain reaction, which showed an association with NPC risk.	Arginine	16-19	tumor protein p53	Homo sapiens	4-7
27159678-11	2016	The outcome of the study indicated that both allele frequency and genotype distribution of p53 codon72 Arg&gt;Pro polymorphism were significantly associated with NPC risk.	Arginine	103-106	tumor protein p53	Homo sapiens	91-94
27102373-4	2016	The utility of Cys(Hmb(off/on)) is demonstrated by the chemical synthesis of an erythropoietin segment, EPO[Cys(98)-Arg(166)]-OH through native chemical ligation.	Arginine	116-119	erythropoietin	Homo sapiens	80-94
27102373-4	2016	The utility of Cys(Hmb(off/on)) is demonstrated by the chemical synthesis of an erythropoietin segment, EPO[Cys(98)-Arg(166)]-OH through native chemical ligation.	Arginine	116-119	erythropoietin	Homo sapiens	104-107
26957205-3	2016	To date, the recognized targets of thrombin cleavage and activation for signaling are PAR1 and PAR4, in which thrombin cleaves at a conserved target arginine to reveal a tethered ligand.	Arginine	149-157	coagulation factor II, thrombin	Homo sapiens	35-43
26940553-0	2016	Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.	Arginine	30-38	chromatin licensing and DNA replication factor 1	Mus musculus	51-55
26940553-0	2016	Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.	Arginine	30-38	geminin	Mus musculus	108-115
26940553-5	2016	We mutagenized the 223th arginine of mouse Cdt1 (mCdt1) to cysteine or serine (R-S or R-C, respectively) and 342nd and 346th arginines constituting an arginine finger-like structure to alanine (RR-AA).	Arginine	25-33	chromatin licensing and DNA replication factor 1	Mus musculus	43-47
26940553-5	2016	We mutagenized the 223th arginine of mouse Cdt1 (mCdt1) to cysteine or serine (R-S or R-C, respectively) and 342nd and 346th arginines constituting an arginine finger-like structure to alanine (RR-AA).	Arginine	25-33	chromatin licensing and DNA replication factor 1	Mus musculus	49-54
26325019-14	2016	Asp interacted with arginine residues of bovine serum albumin particularly ARG 194, ARG 198, and ARG 217 thereby stabilized the protein complex.	Arginine	20-28	albumin	Homo sapiens	48-61
26325019-14	2016	Asp interacted with arginine residues of bovine serum albumin particularly ARG 194, ARG 198, and ARG 217 thereby stabilized the protein complex.	Arginine	75-78	albumin	Homo sapiens	48-61
26325019-14	2016	Asp interacted with arginine residues of bovine serum albumin particularly ARG 194, ARG 198, and ARG 217 thereby stabilized the protein complex.	Arginine	84-87	albumin	Homo sapiens	48-61
26325019-14	2016	Asp interacted with arginine residues of bovine serum albumin particularly ARG 194, ARG 198, and ARG 217 thereby stabilized the protein complex.	Arginine	84-87	albumin	Homo sapiens	48-61
26940553-5	2016	We mutagenized the 223th arginine of mouse Cdt1 (mCdt1) to cysteine or serine (R-S or R-C, respectively) and 342nd and 346th arginines constituting an arginine finger-like structure to alanine (RR-AA).	Arginine	125-134	chromatin licensing and DNA replication factor 1	Mus musculus	43-47
26940553-5	2016	We mutagenized the 223th arginine of mouse Cdt1 (mCdt1) to cysteine or serine (R-S or R-C, respectively) and 342nd and 346th arginines constituting an arginine finger-like structure to alanine (RR-AA).	Arginine	125-133	chromatin licensing and DNA replication factor 1	Mus musculus	43-47
26940553-10	2016	Our results show that conserved arginine residues play critical roles in interaction with Geminin and Mcm that are crucial for proper conformation of the complexes and its licensing activity.	Arginine	32-40	geminin	Mus musculus	90-97
26957205-3	2016	To date, the recognized targets of thrombin cleavage and activation for signaling are PAR1 and PAR4, in which thrombin cleaves at a conserved target arginine to reveal a tethered ligand.	Arginine	149-157	coagulation factor II thrombin receptor	Homo sapiens	86-90
26957205-3	2016	To date, the recognized targets of thrombin cleavage and activation for signaling are PAR1 and PAR4, in which thrombin cleaves at a conserved target arginine to reveal a tethered ligand.	Arginine	149-157	coagulation factor II, thrombin	Homo sapiens	110-118
26957205-4	2016	PAR2, which like PAR1 is also cleaved at an N-terminal arginine to unmask its tethered ligand, is generally regarded as a target for trypsin but not for thrombin signaling.	Arginine	55-63	coagulation factor II thrombin receptor	Homo sapiens	17-21
27017485-0	2016	Regulation of autophagy by systemic admission of microRNA-141 to target HMGB1 in l-arginine-induced acute pancreatitis in vivo.	Arginine	81-91	microRNA 141	Mus musculus	49-61
26708258-8	2016	We identified and confirmed six metabolites that were significantly associated with knee OA, of which arginine was the most significant metabolite (P &lt; 3.5 x 10(-13)) with knee OA patients having on average 69 muM lower than that in controls.	Arginine	102-110	latexin	Homo sapiens	213-216
27017485-10	2016	Furthermore, systemic administration of the miR-141 knock-down the expression of HMGB1 protein and further antagonized the downstream protein Beclin-1, leading to the reduction of autophagosomes and autolysosomes, blockade of the LC3-II level and the increased levels of p62 protein after injection of l-arginine.	Arginine	302-312	microRNA 141	Mus musculus	44-51
26975471-6	2016	Moreover, the results reported here suggest that Arg-24 of Atg16L1 is crucial for its interaction with Atg5 which will have further implication in the binding of the dimeric complex to Rab33B.	Arginine	49-52	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	59-66
26708258-10	2016	The optimal cutoff of arginine concentration was 57 muM with 98.3% sensitivity and 89% specificity.	Arginine	22-30	latexin	Homo sapiens	52-55
27051065-0	2016	Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFalpha/NF-kappaB response.	Arginine	11-19	tumor necrosis factor	Homo sapiens	81-89
27051065-0	2016	Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFalpha/NF-kappaB response.	Arginine	11-19	nuclear factor kappa B subunit 1	Homo sapiens	90-99
27051065-8	2016	Our findings provide evidence for the asymmetric arginine dimethylation of RelA and unveil a unique mechanism controlling TNFalpha/NF-kappaB signaling.	Arginine	49-57	tumor necrosis factor	Homo sapiens	122-130
27051065-8	2016	Our findings provide evidence for the asymmetric arginine dimethylation of RelA and unveil a unique mechanism controlling TNFalpha/NF-kappaB signaling.	Arginine	49-57	nuclear factor kappa B subunit 1	Homo sapiens	131-140
26912789-2	2016	We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83.	Arginine	57-65	protein arginine methyltransferase 5	Homo sapiens	13-18
27105349-6	2016	Combined our results provide evidence that Akt kinases directly phosphorylate an RS domain-containing protein and that both the residues N-terminal the phosphosite and at position +1 are essential for Akt specificity, with the latter substrate position being compatible with the arginine residue of RS-repeats.	Arginine	279-287	AKT serine/threonine kinase 1	Homo sapiens	43-46
27105349-6	2016	Combined our results provide evidence that Akt kinases directly phosphorylate an RS domain-containing protein and that both the residues N-terminal the phosphosite and at position +1 are essential for Akt specificity, with the latter substrate position being compatible with the arginine residue of RS-repeats.	Arginine	279-287	AKT serine/threonine kinase 1	Homo sapiens	201-204
26912789-2	2016	We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83.	Arginine	57-65	AKT serine/threonine kinase 1	Homo sapiens	169-172
26771234-8	2016	On the other hand, overexpression of Atg5 or AMPK-alpha1 in BR cells can redirect arginine deprivation-induced apoptosis toward autophagy.	Arginine	82-90	autophagy related 5	Homo sapiens	37-41
27043018-7	2016	Phosphoproteomics and genetic analysis indicates that the arginine-deprivation response is mediated through a mitogen-activated protein kinase-2-dependent signaling cascade.	Arginine	58-66	mitogen-activated protein kinase 1	Homo sapiens	110-144
26895297-4	2016	To do so, we generated FUS-specific monoclonal antibodies that specifically recognize unmethylated arginine (UMA), monomethylated arginine (MMA) or asymmetrically dimethylated arginine (ADMA).	Arginine	99-107	FUS RNA binding protein	Homo sapiens	23-26
26800978-6	2016	The method is responsive to arginine without the interference from other species in the cerebral system; under the optimized conditions, the A 650/A 520 values are linear with the concentration of arginine within a concentration range from 0.80 to 64 muM, yet remain unchanged with the addition of other kinds of amino acids or the species in the central nervous system into the Au-NPs dispersion containing cysteine.	Arginine	28-36	latexin	Homo sapiens	251-254
26800978-6	2016	The method is responsive to arginine without the interference from other species in the cerebral system; under the optimized conditions, the A 650/A 520 values are linear with the concentration of arginine within a concentration range from 0.80 to 64 muM, yet remain unchanged with the addition of other kinds of amino acids or the species in the central nervous system into the Au-NPs dispersion containing cysteine.	Arginine	197-205	latexin	Homo sapiens	251-254
27058169-7	2016	The HAESA co-receptor SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in IDA.	Arginine	157-160	mitogen-activated protein kinase kinase 4	Homo sapiens	22-27
26771234-0	2016	BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma.	Arginine	52-60	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
26972470-2	2016	The protein contains a functional PDZ domain that has been solved in complex with a phage display-derived heptapeptide: Asp-6 Ser-5 Arg-4 Ile-3 Trp-2 Trp-1 Val0 .	Arginine	132-135	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	144-149
26927423-5	2016	Concurrent crystallography-driven exploration of the ribose pocket and the solvent front led to analogs with optimized kinome and JAK1 selectivities over the JAK2 isoform by targeting several residues unique to JAK1, such as Arg-879 and Glu-966.	Arginine	225-228	Janus kinase 1	Homo sapiens	211-215
26878866-3	2016	The bactericidal and immunomodulatory properties of LL-37 depend on its secondary structure and cationic nature, which are conferred by arginine and lysine residues.	Arginine	136-144	cathelicidin antimicrobial peptide	Homo sapiens	52-57
27083312-2	2016	Asymmetrical dimethylarginine (ADMA), formed by the hydrolysis of proteins containing methylated arginine residues, is an endogenous inhibitor of nitric oxide synthase (NOS), which oxidize l-arginine to citruline and nitric oxide (NO), related to hyperinsulinaemia and hyperlipidaemia.	Arginine	21-29	nitric oxide synthase 2	Homo sapiens	146-167
27083312-2	2016	Asymmetrical dimethylarginine (ADMA), formed by the hydrolysis of proteins containing methylated arginine residues, is an endogenous inhibitor of nitric oxide synthase (NOS), which oxidize l-arginine to citruline and nitric oxide (NO), related to hyperinsulinaemia and hyperlipidaemia.	Arginine	189-199	nitric oxide synthase 2	Homo sapiens	146-167
26874855-2	2016	We aimed to establish a cut-off value for the GHRH-arginine test (GHRH+ARG) at the typical age of retesting at near-adult height.	Arginine	51-59	growth hormone releasing hormone	Homo sapiens	46-50
26874855-2	2016	We aimed to establish a cut-off value for the GHRH-arginine test (GHRH+ARG) at the typical age of retesting at near-adult height.	Arginine	51-59	growth hormone releasing hormone	Homo sapiens	66-70
26874855-2	2016	We aimed to establish a cut-off value for the GHRH-arginine test (GHRH+ARG) at the typical age of retesting at near-adult height.	Arginine	71-74	growth hormone releasing hormone	Homo sapiens	46-50
26792398-3	2016	These hindered the amyloidogenesis of Abeta and its neurotoxicity in vitro, suggesting a basis for the design of a new small peptide in D-isomeric form, linked to the arginine-rich TAT sequence [Abeta1-6A2V-TAT(D)], to allow translocation across biological membranes and the blood-brain barrier.	Arginine	167-175	amyloid beta precursor protein	Homo sapiens	38-43
26536822-3	2016	In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	Arginine	144-152	protein arginine methyltransferase 5	Homo sapiens	14-19
26603295-3	2016	Since the arginine methylations are implicated in the nuclear-cytoplasmic shuttling of FUS, a methylation inhibitor could be one of therapeutic targets for FUS-linked ALS.	Arginine	10-18	FUS RNA binding protein	Homo sapiens	87-90
26908914-8	2016	The PTDM group also exhibited a significantly lower insulin response to arginine (P = 0.01) but similar glucagon and proinsulin responses compared with control subjects.	Arginine	72-80	insulin	Homo sapiens	52-59
26786060-5	2016	TAFI also plays a role in inflammatory processes via the removal of C-terminal arginine or lysine residues from bradykinin, thrombin-cleaved osteopontin, C3a, C5a and chemerin.	Arginine	79-87	kininogen 1	Homo sapiens	112-122
26786060-5	2016	TAFI also plays a role in inflammatory processes via the removal of C-terminal arginine or lysine residues from bradykinin, thrombin-cleaved osteopontin, C3a, C5a and chemerin.	Arginine	79-87	complement C5a receptor 1	Homo sapiens	159-162
27117808-0	2016	A novel mutation affecting the arginine-137 residue of AVPR2 in dizygous twins leads to nephrogenic diabetes insipidus and attenuated urine exosome aquaporin-2.	Arginine	31-39	arginine vasopressin receptor 2	Homo sapiens	55-60
27117808-3	2016	We present a novel mutation in codon 137 within AVPR2 with substitution of glycine for arginine in male dizygotic twins.	Arginine	87-95	arginine vasopressin receptor 2	Homo sapiens	48-53
27020049-4	2016	Macrophages use L-arginine to synthesize nitric oxide (NO) through inducible NO synthase (iNOS), and the released NO contributes to the tumoricidal activity of macrophages.	Arginine	16-26	nitric oxide synthase 2, inducible	Mus musculus	67-88
27060305-9	2016	DNA sequencing has confirmed that the proband, his mother, brother, and nephew have all carried a g.5877G&gt;A mutation in the exon 8 of the FGG gene, which resulted in replacement of arginine (Arg) by histidine (His) at position 275.	Arginine	184-192	fibrinogen gamma chain	Homo sapiens	141-144
27060305-9	2016	DNA sequencing has confirmed that the proband, his mother, brother, and nephew have all carried a g.5877G&gt;A mutation in the exon 8 of the FGG gene, which resulted in replacement of arginine (Arg) by histidine (His) at position 275.	Arginine	194-197	fibrinogen gamma chain	Homo sapiens	141-144
26096933-4	2016	Here, we report that an immediate-early event of Arg-auxotrophic response involves reactive oxygen species-mediated secretion of Gas6, which interacts with its receptor Axl and activates the downstream Ras/PI3K/Akt growth signal leading to accumulation of c-Myc by protein stabilization.	Arginine	49-52	AKT serine/threonine kinase 1	Homo sapiens	211-214
27020049-4	2016	Macrophages use L-arginine to synthesize nitric oxide (NO) through inducible NO synthase (iNOS), and the released NO contributes to the tumoricidal activity of macrophages.	Arginine	16-26	nitric oxide synthase 2, inducible	Mus musculus	90-94
26934207-5	2016	Treatment with AR was furthermore shown to promote thermotolerance in a DAF-16- and SIR-2.1-dependent manner, where DAF-16 and SIR-2.1 are homologs of FoxO and SirT1, respectively.	Arginine	15-17	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	84-91
26934207-5	2016	Treatment with AR was furthermore shown to promote thermotolerance in a DAF-16- and SIR-2.1-dependent manner, where DAF-16 and SIR-2.1 are homologs of FoxO and SirT1, respectively.	Arginine	15-17	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	127-134
26934207-6	2016	Taken together, these data suggest that AR is one of the active components of NP and promotes thermotolerance via the activation of DAF-16 and SIR-2.1.	Arginine	40-42	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	143-150
27014078-0	2016	Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels.	Arginine	68-78	insulin	Homo sapiens	25-32
27117097-6	2016	Because of the low concentration of L-aspartate (L-Asp) in the blood, AST is the only enzyme, which supply of this amino acid as a substrate for many metabolic processes, such as urea cycle or purine and pyrimidine nucleotides in the liver, synthesis of L-arginine in the kidney and purine nucleotide cycle in the brain and the skeletal muscle.	Arginine	254-264	solute carrier family 17 member 5	Homo sapiens	70-73
26763231-10	2016	These findings support a molecular model of prothrombin activation where Lnk2 presents the sites of cleavage at Arg(271) and Arg(320) to factor Xa in different orientations by pivoting the C-terminal kringle-2/protease domain pair on the N-terminal Gla domain/kringle-1 pair anchored to the membrane.	Arginine	112-115	coagulation factor II, thrombin	Homo sapiens	44-55
26763231-10	2016	These findings support a molecular model of prothrombin activation where Lnk2 presents the sites of cleavage at Arg(271) and Arg(320) to factor Xa in different orientations by pivoting the C-terminal kringle-2/protease domain pair on the N-terminal Gla domain/kringle-1 pair anchored to the membrane.	Arginine	125-128	coagulation factor II, thrombin	Homo sapiens	44-55
26986975-2	2016	A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders.	Arginine	65-73	purinergic receptor P2X 7	Homo sapiens	124-137
26986975-2	2016	A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders.	Arginine	65-73	purinergic receptor P2X 7	Homo sapiens	139-144
26986975-2	2016	A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders.	Arginine	75-78	purinergic receptor P2X 7	Homo sapiens	124-137
26986975-2	2016	A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders.	Arginine	75-78	purinergic receptor P2X 7	Homo sapiens	139-144
26409025-8	2016	This probe was used for the screening of ALP inhibitors, including Na3VO4, imidazole, and arginine.	Arginine	90-98	alkaline phosphatase, placental	Homo sapiens	41-44
26811873-6	2016	A metabolic pathway analysis also indicated that insulin affected the metabolism of alanine, aspartate and glutamate, as well as that of arginine and proline.	Arginine	137-145	insulin	Homo sapiens	49-56
27014078-2	2016	In human endothelium, cationic amino acid transporter 1 (hCAT-1) is related to the synthesis of nitric oxide (NO) and insulin has a vascular effect in endothelial cells through a signaling pathway that involves increases in hCAT-1 expression and L-arginine transport.	Arginine	246-256	insulin	Homo sapiens	118-125
28955863-3	2016	RESULTS: In case of CuO np-HSA interaction, the distances from the centre of Subdomain IIIA to Arg-472 is 2.113 A and Lys 475, Glu 492, Ala 490, Cys 487, Ala 490 are the bound neighbouring residues with Lys 475, Glu 492 at aliphatic region.	Arginine	95-98	albumin	Homo sapiens	27-30
26940652-7	2016	The critical regulatory metabolites succinate, gamma-aminobutyric acid, arginine, ornithine and adenosine were increased in LPS-stimulated macrophages from young mice, but not macrophages from old mice.	Arginine	72-80	toll-like receptor 4	Mus musculus	124-127
26826241-11	2016	Suppression of IFN-gamma production was reversed by l-arginine supplementation, consistent with increased MDSC arginase-1 activity.	Arginine	52-62	interferon gamma	Homo sapiens	15-24
26759235-0	2016	Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth.	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	36-41
26630691-1	2016	BACKGROUND: The growth hormone (GH) stimulation protocols for clonidine and arginine tests are non-standardized and can be lengthy.	Arginine	76-84	growth hormone 1	Homo sapiens	16-30
26630691-1	2016	BACKGROUND: The growth hormone (GH) stimulation protocols for clonidine and arginine tests are non-standardized and can be lengthy.	Arginine	76-84	growth hormone 1	Homo sapiens	32-34
26710791-0	2016	Insulin requires A1 adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium.	Arginine	93-103	insulin	Homo sapiens	0-7
25135690-0	2016	Arginine Supplementation Induces Arginase Activity and Inhibits TNF-alpha Synthesis in Mice Spleen Macrophages After Intestinal Obstruction.	Arginine	0-8	tumor necrosis factor	Mus musculus	64-73
25135690-1	2016	BACKGROUND: The purpose of this study was to assess the effect of arginine supplementation on arginase activity, tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) synthesis in cultured splenic macrophages from a murine model of intestinal obstruction (IO).	Arginine	66-74	interleukin 10	Mus musculus	157-171
25135690-7	2016	Arginine was also related to a decrease in TNF-alpha levels (Arg vs IO group, P &lt; .05) and maintenance of IL-10 levels (Arg vs other groups, P &gt; .05).	Arginine	0-8	tumor necrosis factor	Mus musculus	43-52
25135690-7	2016	Arginine was also related to a decrease in TNF-alpha levels (Arg vs IO group, P &lt; .05) and maintenance of IL-10 levels (Arg vs other groups, P &gt; .05).	Arginine	0-8	interleukin 10	Mus musculus	109-114
25135690-7	2016	Arginine was also related to a decrease in TNF-alpha levels (Arg vs IO group, P &lt; .05) and maintenance of IL-10 levels (Arg vs other groups, P &gt; .05).	Arginine	0-3	tumor necrosis factor	Mus musculus	43-52
25135690-7	2016	Arginine was also related to a decrease in TNF-alpha levels (Arg vs IO group, P &lt; .05) and maintenance of IL-10 levels (Arg vs other groups, P &gt; .05).	Arginine	0-3	interleukin 10	Mus musculus	109-114
25135690-10	2016	Arginine availability decreased plasma TNF-alpha levels, which may be directly related to nitric oxide derived from arginine.	Arginine	0-8	tumor necrosis factor	Mus musculus	39-48
25135690-10	2016	Arginine availability decreased plasma TNF-alpha levels, which may be directly related to nitric oxide derived from arginine.	Arginine	116-124	tumor necrosis factor	Mus musculus	39-48
26710791-2	2016	In this study we aim to determine whether insulin reverses GDM-increased L-arginine transport requiring adenosine receptors expression in HUVECs.	Arginine	73-83	insulin	Homo sapiens	42-49
26710791-4	2016	Insulin effect was assayed on human cationic amino acid transporter 1 (hCAT1) expression (protein, mRNA, SLC7A1 promoter activity) and activity (initial rates of L-arginine transport) in the absence or presence of adenosine receptors agonists or antagonists.	Arginine	162-172	insulin	Homo sapiens	0-7
26901772-4	2016	We have previously reported that the protein arginine methyltransferase PRMT5 catalyzes symmetrical dimethylation of the NF-kappaB subunit p65 in EC at multiple arginine residues.	Arginine	45-53	protein arginine methyltransferase 5	Homo sapiens	72-77
26927806-7	2016	Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association.	Arginine	72-75	S100 calcium binding protein B	Homo sapiens	132-135
26927806-7	2016	Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association.	Arginine	92-95	S100 calcium binding protein B	Homo sapiens	132-135
26909997-6	2016	TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg.	Arginine	140-143	tumor protein p53	Homo sapiens	0-4
26909997-6	2016	TP53*72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Arg; in the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg.	Arginine	241-244	tumor protein p53	Homo sapiens	0-4
26909997-10	2016	In TP53*248, there was 100% homozygous Arg distribution in both groups.	Arginine	39-42	tumor protein p53	Homo sapiens	3-7
26704974-4	2016	PARP-2 has a modular architecture composed of a C-terminal catalytic domain (CAT), a central Trp-Gly-Arg (WGR) domain and an N-terminal region (NTR).	Arginine	101-104	poly(ADP-ribose) polymerase 2	Homo sapiens	0-6
26901772-4	2016	We have previously reported that the protein arginine methyltransferase PRMT5 catalyzes symmetrical dimethylation of the NF-kappaB subunit p65 in EC at multiple arginine residues.	Arginine	45-53	nuclear factor kappa B subunit 1	Homo sapiens	121-130
26824386-6	2016	Screening a fragment library against PRMT6 produced numerous hits, including a 300 nM inhibitor (ligand efficiency of 0.56) that decreased global histone 3 arginine 2 methylation in cells, and can serve as a warhead for the development of PRMT chemical probes.	Arginine	156-164	protein arginine methyltransferase 6	Homo sapiens	37-42
26865023-2	2016	Arginine uptake mainly occurs through three amino acid permeases, Alp1p, Gap1p and Can1p, which act as both transporters and receptors for amino acid utilization.	Arginine	0-8	amino acid permease GAP1	Saccharomyces cerevisiae S288C	73-78
26567119-2	2016	METHODS: For this purpose, several ZnT8 C-terminal domain variants were designed: monomer carrying Arg325 or Trp325, homo-dimers ZnT8-Arg-Arg325 and ZnT8-Trp-Trp325, and hetero-dimer ZnT8-Arg-Trp325.	Arginine	99-102	solute carrier family 30 member 8	Homo sapiens	35-39
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Arginine	65-73	heat shock protein family A (Hsp70) member 9	Homo sapiens	233-238
26515034-2	2016	NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes.	Arginine	23-31	nitric oxide synthase 2	Homo sapiens	61-72
26718886-9	2016	The patients with a proline (Pro) polymorphism in SNP72 of TP53 showed significantly higher PrP-positive rates than those with arginine (Arg).	Arginine	137-140	tumor protein p53	Homo sapiens	59-63
26728997-0	2016	Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.	Arginine	72-80	fms related receptor tyrosine kinase 1	Homo sapiens	22-27
26728997-0	2016	Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation.	Arginine	72-80	fms related receptor tyrosine kinase 1	Homo sapiens	29-36
26728997-8	2016	These findings indicate that hnRNP D and arginine methylation play important roles in the regulation of Flt-1 mRNA alternative polyadenylation.	Arginine	41-49	fms related receptor tyrosine kinase 1	Homo sapiens	104-109
26751966-4	2016	Tumor suppressor protein p53 activation and G1/G0 cell cycle arrest support cell survival upon prolonged arginine starvation.	Arginine	105-113	tumor protein p53	Homo sapiens	25-28
26751966-5	2016	Cells with the mutant or deleted TP53 fail to stop cell cycle progression at defined cell cycle checkpoints which appears to be associated with reduced recovery after durable metabolic stress triggered by arginine withdrawal.	Arginine	205-213	tumor protein p53	Homo sapiens	33-37
26454877-0	2016	Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast.	Arginine	116-126	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	80-84
26454877-1	2016	Previously, N-Acetyltransferase Mpr1 was suggested to be involved in a novel pathway of L-arginine biosynthesis in yeast.	Arginine	88-98	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	32-36
26454877-6	2016	Our growth assay suggests that overexpression of the stable Mpr1 variants increase L-arginine synthesis in yeast cells.	Arginine	83-93	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	60-64
26454877-7	2016	Our finding is the first report on the rational engineering of Mpr1 for thermostabilization and could be useful in the construction of new yeast strains with higher L-arginine synthetic activity and also improved fermentation ability.	Arginine	165-175	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	63-67
26448477-1	2016	Nitric oxide synthase (NOS) is a multidomain enzyme that catalyzes the production of nitric oxide (NO) by oxidizing L-Arg to NO and L-citrulline.	Arginine	116-121	nitric oxide synthase 2	Homo sapiens	0-21
26628340-8	2016	In conclusion, the dietary level of L-Arg increased the liver fractional protein synthesis rate and fractional protein gain rate of laying hens, and the action of an appropriate level of dietary L-Arg involves upregulating the gene expression of the TOR signaling pathway accompanied by suppressing the mRNA expression of cathepsin B and 20S proteasome in the liver.	Arginine	195-200	cathepsin B	Gallus gallus	322-333
26657730-8	2016	We show that BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239.	Arginine	102-110	activating transcription factor 4	Mus musculus	33-37
26761588-1	2016	Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG).	Arginine	57-65	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	85-89
26811329-6	2016	More interestingly, GGA3 physically interacted with alpha2B-AR, and the interaction sites were identified as the triple Arg motif in the third intracellular loop of the receptor and the acidic motif EDWE in the VHS domain of GGA3.	Arginine	120-123	golgi associated, gamma adaptin ear containing, ARF binding protein 3	Homo sapiens	20-24
26657730-8	2016	We show that BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239.	Arginine	102-110	activating transcription factor 4	Mus musculus	149-153
26612772-3	2016	The analysis of candidate genes showed that patient was homozygous for a variant (c.1594 C&gt;T) in the APOB gene causing arginine to tryptophan conversion at position 505 of mature apoB (Arg505Trp).	Arginine	122-130	apolipoprotein B	Homo sapiens	104-108
26612772-3	2016	The analysis of candidate genes showed that patient was homozygous for a variant (c.1594 C&gt;T) in the APOB gene causing arginine to tryptophan conversion at position 505 of mature apoB (Arg505Trp).	Arginine	122-130	apolipoprotein B	Homo sapiens	182-186
27173965-5	2016	SAA2 specifically displayed binding to the N-terminal Thr1 residue in the S1 pocket of Mus musculus beta5 proteasome along with threonine, lysine and arginine; conventionally involved major amino acid residues in ligand binding.	Arginine	150-158	serum amyloid A 2	Mus musculus	0-4
26739766-0	2016	Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway.	Arginine	123-133	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	42-46
26739766-9	2016	In summary, here we report for the first time that inhibition of UT-B plays an important role in regulating vasorelaxations and blood pressure via up-regulation of L-arginine-eNOS-NO pathway, and it may become another potential therapeutic target for the treatment of hypertension.	Arginine	164-174	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	65-69
26742086-5	2016	Instead, arginine specifically suppresses lysosomal localization of the TSC complex and interaction with its target small GTPase protein, Rheb.	Arginine	9-17	TSC complex subunit 1	Homo sapiens	72-75
26742086-6	2016	By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC.	Arginine	38-46	TSC complex subunit 1	Homo sapiens	20-23
26742086-6	2016	By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC.	Arginine	38-46	TSC complex subunit 1	Homo sapiens	89-92
26610360-7	2016	Genetic assessment carried out a year and a half later confirmed the diagnosis, with arginine substitution at position 201 of Gs alpha protein.	Arginine	85-93	GNAS complex locus	Homo sapiens	126-134
28757709-7	2016	The nucleotide exchange leads to an amino acid alteration to the protein sequence of DRB1*16:02:01 at residue 93 where the arginine (R) of DRB1*16:02:01 is changed to the tryptophan (W) of DRB1*16:35.	Arginine	123-131	major histocompatibility complex, class II, DR beta 1	Homo sapiens	85-89
26696550-5	2016	RESULTS: The Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to capecitabine plus paclitaxel chemotherapy in patients with gastric cancer when compared to the Arg/Arg genotype (30.6 vs. 63.2%, p value 0.000).	Arginine	203-206	tumor protein p53	Homo sapiens	34-38
26696550-5	2016	RESULTS: The Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to capecitabine plus paclitaxel chemotherapy in patients with gastric cancer when compared to the Arg/Arg genotype (30.6 vs. 63.2%, p value 0.000).	Arginine	207-210	tumor protein p53	Homo sapiens	34-38
26797053-5	2016	Following cytosolic relocalization and arginylation, Nt-arginylated HSPA5 (R-HSPA5) is targeted to autophagosomes and degraded by lysosomal hydrolases through the interaction of its N-terminal Arg (Nt-Arg) with ZZ domain of SQSTM1.	Arginine	193-196	heat shock protein family A (Hsp70) member 5	Homo sapiens	68-73
26797053-5	2016	Following cytosolic relocalization and arginylation, Nt-arginylated HSPA5 (R-HSPA5) is targeted to autophagosomes and degraded by lysosomal hydrolases through the interaction of its N-terminal Arg (Nt-Arg) with ZZ domain of SQSTM1.	Arginine	193-196	heat shock protein family A (Hsp70) member 5	Homo sapiens	75-82
26872252-8	2016	A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF.	Arginine	35-43	gremlin 1, DAN family BMP antagonist	Homo sapiens	118-127
28757709-7	2016	The nucleotide exchange leads to an amino acid alteration to the protein sequence of DRB1*16:02:01 at residue 93 where the arginine (R) of DRB1*16:02:01 is changed to the tryptophan (W) of DRB1*16:35.	Arginine	123-131	major histocompatibility complex, class II, DR beta 1	Homo sapiens	139-143
28757709-7	2016	The nucleotide exchange leads to an amino acid alteration to the protein sequence of DRB1*16:02:01 at residue 93 where the arginine (R) of DRB1*16:02:01 is changed to the tryptophan (W) of DRB1*16:35.	Arginine	123-131	major histocompatibility complex, class II, DR beta 1	Homo sapiens	139-143
27464520-2	2016	It is produced from the amino acid L-Arginine and oxygen by the enzymatic action of three isoforms of the Nitric Oxide Synthase (NOS), differently expressed and regulated in tissues.	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	106-127
26971935-0	2016	Altered Arginine Metabolism in Cells Transfected with Human Wild-Type Beta Amyloid Precursor Protein (betaAPP).	Arginine	8-16	amyloid beta precursor protein	Homo sapiens	70-100
26971935-2	2016	Despite strong association of arginine changes with nitric oxide (NO) pathway, the impact of amyloid beta (Abeta) peptides on arginine degradation and re-synthesis is unknown.	Arginine	126-134	amyloid beta precursor protein	Homo sapiens	107-112
26971935-12	2016	Our results indicate that Abeta affects arginine metabolism and this influence might have important role in the pathomechanism of AD.	Arginine	40-48	amyloid beta precursor protein	Homo sapiens	26-31
26738694-7	2016	Moreover, genotype analysis revealed a statistically significant association between Pro/Pro genotype of p53 Arg72Pro polymorphism and increased frequencies of MN both spontaneous and AFB1-induced cultures when compared Arg/Arg genotype (0.69 +- 0.19 versus 0.46 +- 0.13, p &lt; 0.001; 1.59 +- 0.65 versus 1.01 +- 0.41 p &lt; 0.001; respectively).	Arginine	109-112	tumor protein p53	Homo sapiens	105-108
26738694-7	2016	Moreover, genotype analysis revealed a statistically significant association between Pro/Pro genotype of p53 Arg72Pro polymorphism and increased frequencies of MN both spontaneous and AFB1-induced cultures when compared Arg/Arg genotype (0.69 +- 0.19 versus 0.46 +- 0.13, p &lt; 0.001; 1.59 +- 0.65 versus 1.01 +- 0.41 p &lt; 0.001; respectively).	Arginine	220-223	tumor protein p53	Homo sapiens	105-108
26449889-5	2016	Both naive and memory CD4(+) T cells as well as CD8(+) T cells specifically upregulated the human cationic amino acid transporter-1 (hCAT-1), with an enhanced and persistent expression under arginine starvation.	Arginine	191-199	CD4 molecule	Homo sapiens	22-25
26209050-10	2016	The gene-gene interaction of these polymorphisms increased EOC risk in a more than additive manner (ORs for the presence of both BAX AA and TP53 Arg/Pro genotypes = 8.7, 95 % CI = 1.66-45.48).	Arginine	145-148	tumor protein p53	Homo sapiens	140-144
26763441-0	2016	MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCdelta/p38delta Signaling.	Arginine	47-55	protein arginine methyltransferase 5	Homo sapiens	6-11
27610157-3	2016	Molecular modeling studies indicated that the methylsulfonyl substituent can be inserted into the secondary pocket of COX-2 active site for interactions with Arg(513).	Arginine	158-161	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	118-123
25730443-0	2016	Interaction of arginine, lysine, and guanidine with surface residues of lysozyme: implication to protein stability.	Arginine	15-23	lysozyme	Homo sapiens	72-80
25730443-3	2016	To understand this, we herein perform molecular dynamics simulations of lysozyme in the presence of three commonly used additives: arginine, lysine, and guanidine.	Arginine	131-139	lysozyme	Homo sapiens	72-80
28203651-6	2016	SNP analysis of p53 codon 72 demonstrated the highest prevalence of the Arg/Arg (56%) phenotype, followed by Arg/Pro (33%) and Pro/Pro (11%).	Arginine	72-75	tumor protein p53	Homo sapiens	16-19
28203651-6	2016	SNP analysis of p53 codon 72 demonstrated the highest prevalence of the Arg/Arg (56%) phenotype, followed by Arg/Pro (33%) and Pro/Pro (11%).	Arginine	76-79	tumor protein p53	Homo sapiens	16-19
28203651-6	2016	SNP analysis of p53 codon 72 demonstrated the highest prevalence of the Arg/Arg (56%) phenotype, followed by Arg/Pro (33%) and Pro/Pro (11%).	Arginine	76-79	tumor protein p53	Homo sapiens	16-19
26365434-12	2016	L-Arg consentrations in Group 1 were 8.7 +- 4.1 muM/L and 11.9 +- 5.0 muM/L in first and seventh day, respectively.	Arginine	0-5	latexin	Homo sapiens	48-51
26365434-12	2016	L-Arg consentrations in Group 1 were 8.7 +- 4.1 muM/L and 11.9 +- 5.0 muM/L in first and seventh day, respectively.	Arginine	0-5	latexin	Homo sapiens	70-73
26365434-13	2016	L-Arg consentrations were 12.6 +- 4.5 muM/Land 10.9 +- 5.4 muM/L in Group 2 and 8.6 +- 5.1 muM/L and 9.4 +- 4.1 muM/L in Group 3.	Arginine	0-5	latexin	Homo sapiens	38-41
26365434-13	2016	L-Arg consentrations were 12.6 +- 4.5 muM/Land 10.9 +- 5.4 muM/L in Group 2 and 8.6 +- 5.1 muM/L and 9.4 +- 4.1 muM/L in Group 3.	Arginine	0-5	latexin	Homo sapiens	59-62
26365434-13	2016	L-Arg consentrations were 12.6 +- 4.5 muM/Land 10.9 +- 5.4 muM/L in Group 2 and 8.6 +- 5.1 muM/L and 9.4 +- 4.1 muM/L in Group 3.	Arginine	0-5	latexin	Homo sapiens	59-62
26365434-13	2016	L-Arg consentrations were 12.6 +- 4.5 muM/Land 10.9 +- 5.4 muM/L in Group 2 and 8.6 +- 5.1 muM/L and 9.4 +- 4.1 muM/L in Group 3.	Arginine	0-5	latexin	Homo sapiens	59-62
26763441-0	2016	MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCdelta/p38delta Signaling.	Arginine	47-55	mitogen-activated protein kinase 13	Homo sapiens	101-109
26763441-3	2016	Protein arginine methyltransferase 5 (PRMT5) is an arginine methyltransferase that symmetrically dimethylates arginine residues.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
26763441-9	2016	We propose that PRMT5/MEP50-dependent methylation is an epigenetic mechanism that assists in silencing of hINV expression, and that PKCdelta signaling activates gene expression by directly activating transcription and by suppressing PRMT5/MEP50-dependent arginine dimethylation of promoter-associated histones.	Arginine	255-263	protein arginine methyltransferase 5	Homo sapiens	16-21
26763441-9	2016	We propose that PRMT5/MEP50-dependent methylation is an epigenetic mechanism that assists in silencing of hINV expression, and that PKCdelta signaling activates gene expression by directly activating transcription and by suppressing PRMT5/MEP50-dependent arginine dimethylation of promoter-associated histones.	Arginine	255-263	protein arginine methyltransferase 5	Homo sapiens	233-238
26602113-1	2016	Arginine is the substrate for nitric oxide synthases (NOS), thus the production of nitric oxide (NO) is based on arginine availability.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	30-52
26545797-11	2016	A homology model of 17beta-HSD3 predicted that arginine or any other bulky residue at position 133 causes steric hindrance of cofactor NADPH binding, whereas substrate binding seems to be unaffected.	Arginine	47-55	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	20-31
26602113-1	2016	Arginine is the substrate for nitric oxide synthases (NOS), thus the production of nitric oxide (NO) is based on arginine availability.	Arginine	113-121	nitric oxide synthase 2	Homo sapiens	30-52
26188014-3	2016	IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG).	Arginine	134-137	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	167-171
26471966-3	2016	As a free radical, NO is synthesized in all mammalian cells by L-Arg with the activity of NO synthase (NOS).	Arginine	63-68	nitric oxide synthase 2	Homo sapiens	90-101
26429923-7	2016	We found that a high arginine content in protamine 1 associates with a lower sperm head width, which may have an impact on sperm swimming velocity.	Arginine	21-29	protamine 1	Homo sapiens	41-52
26429923-8	2016	Increase in arginine content in protamine 1 across mammals appears to take place in a way consistent with sexual selection.	Arginine	12-20	protamine 1	Homo sapiens	32-43
26188014-3	2016	IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG).	Arginine	155-158	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	167-171
26721863-4	2016	RZ-1B and RZ-1C were localized to nuclear speckles and interacted with a spectrum of serine/arginine-rich (SR) proteins through their C termini.	Arginine	92-100	RNA-binding (RRM/RBD/RNP motifs) family protein with retrovirus zinc finger-like domain-containing protein	Arabidopsis thaliana	10-15
26785263-1	2016	BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele.	Arginine	70-78	tumor protein p53	Homo sapiens	99-103
26785263-1	2016	BACKGROUND: In human papillomavirus (HPV)-induced carcinogenesis, the arginine (Arg) allele of the TP53 codon 72 polymorphism binds more efficiently to the HPV E6 oncoprotein than the proline (Pro) allele.	Arginine	80-83	tumor protein p53	Homo sapiens	99-103
26785263-8	2016	Most OPSCC patients had the TP53 Arg/Arg or Arg/Pro genotype.	Arginine	33-36	tumor protein p53	Homo sapiens	28-32
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	9-17	chromogranin A	Homo sapiens	0-3
27586181-3	2016	While apoA-I possesses class A amphipathic helical structures, apoE possesses a 59 residue long amphipathic helical domain linked to a four helix bundle containing the Arg-rich, 10 residue receptor binding domain.	Arginine	168-171	apolipoprotein E	Homo sapiens	63-67
27586181-7	2016	When this peptide (18A) was covalently linked to the Arg-rich receptor binding domain of apoE, the resulting peptide Ac-hE18A-NH2, in which hE refers to the 141-150 Arg-rich region of apoE, dramatically reduced plasma cholesterol in several dyslipidemic animal models, resulting in the reduction of lesion formation.	Arginine	53-56	apolipoprotein E	Homo sapiens	89-93
26795139-2	2016	PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine and arginine at position 192 and the other leucine and methionine at position 55.	Arginine	100-108	paraoxonase 1	Homo sapiens	0-4
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	161-169	chromogranin A	Homo sapiens	0-3
26464485-0	2015	Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine beta-synthase p.R336C.	Arginine	51-54	cystathionine beta-synthase	Homo sapiens	100-127
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Arginine	78-81	tumor protein p53	Homo sapiens	12-15
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Arginine	122-125	tumor protein p53	Homo sapiens	12-15
26782376-10	2015	Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes.	Arginine	122-125	tumor protein p53	Homo sapiens	12-15
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Arginine	135-138	cystathionine beta-synthase	Homo sapiens	94-97
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Arginine	240-243	cystathionine beta-synthase	Homo sapiens	94-97
26420019-5	2015	Arginine analogue 10a, characterized by an acylsulfonamide isosteric replacement of the carboxylate, showed a 13-fold greater inhibitory potential relative to the known DDAH-1 inhibitor, L-257.	Arginine	0-8	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	169-175
26522927-8	2015	In isolated cardiomyocytes (n=3-5), 1nM insulin caused cationic amino acid transporter-1 to redistribute to the cellular membrane from the cytosol and the effects of insulin on l-arginine uptake were partially dependent on the PI3K/Akt pathway.	Arginine	177-187	thymoma viral proto-oncogene 1	Mus musculus	232-235
26420019-0	2015	Arginine analogues incorporating carboxylate bioisosteric functions are micromolar inhibitors of human recombinant DDAH-1.	Arginine	0-8	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	115-121
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Arginine	81-89	signal transducer and activator of transcription 3	Mus musculus	184-234
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Arginine	81-89	signal transducer and activator of transcription 3	Mus musculus	236-241
26653556-2	2015	The objective of this study was to evaluate the efficacy of L-arginine (L-Arg) and vitamin C supplementation as a potentially useful strategy for modulation of serum homocysteine (Hcy) levels, tumor necrosis factor alpha (TNF-alpha), oxidative stress, and insulin resistance induced by HFD in rats.	Arginine	60-70	tumor necrosis factor	Rattus norvegicus	193-220
26507655-6	2015	We then introduced arginine residues at all positions in the 12 TM segments (223 mutants) of P-gp.	Arginine	19-27	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
26399751-5	2015	Positively charged residues with different side chain lengths were incorporated at each Arg and Lys position in the Tat-derived peptide to enhance TAR RNA binding.	Arginine	88-91	RNA binding motif protein 8A	Homo sapiens	147-150
26446785-1	2015	Our molecular modeling studies suggest a charge-dependent interaction between residues Glu-497 in the relay domain and Arg-712 in the converter domain of human beta-cardiac myosin.	Arginine	119-122	Myosin heavy chain	Drosophila melanogaster	173-179
26215736-4	2015	Preinduction of HSP70 enhanced serum arginine and intestinal SCL7A7 expression and inhibited NF-kappaB activation compared with PI-IBS model.	Arginine	37-45	heat shock protein 1B	Mus musculus	16-21
26653556-2	2015	The objective of this study was to evaluate the efficacy of L-arginine (L-Arg) and vitamin C supplementation as a potentially useful strategy for modulation of serum homocysteine (Hcy) levels, tumor necrosis factor alpha (TNF-alpha), oxidative stress, and insulin resistance induced by HFD in rats.	Arginine	60-70	tumor necrosis factor	Rattus norvegicus	222-231
26653556-2	2015	The objective of this study was to evaluate the efficacy of L-arginine (L-Arg) and vitamin C supplementation as a potentially useful strategy for modulation of serum homocysteine (Hcy) levels, tumor necrosis factor alpha (TNF-alpha), oxidative stress, and insulin resistance induced by HFD in rats.	Arginine	72-77	tumor necrosis factor	Rattus norvegicus	193-220
26653556-7	2015	Moreover, Hcy and TNF-alpha levels were reduced in L-Arg supplemented group.	Arginine	51-56	tumor necrosis factor	Rattus norvegicus	18-27
26653556-9	2015	L-Arg plus vitamin C enhanced L-Arg effect on TAS and protected against TNF-alpha increase.	Arginine	0-5	tumor necrosis factor	Rattus norvegicus	72-81
26362868-0	2015	The regulation of ER export and Golgi retention of ST3Gal5 (GM3/GM4 synthase) and B4GalNAcT1 (GM2/GD2/GA2 synthase) by arginine/lysine-based motif adjacent to the transmembrane domain.	Arginine	119-127	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	51-58
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-34	nitric oxide synthase 2, inducible	Mus musculus	79-92
26349791-11	2015	l-Arginine 100mg/kg+theophylline 20mg/kg suppressed TNF-alpha and elevates IL-10 level as well as reversed adjuvant-induced elevated arthritic parameters as compared to only adjuvant and prednisone group (p&lt;0.001).	Arginine	0-10	tumor necrosis factor	Rattus norvegicus	52-61
26571394-0	2015	Old dog, new tricks: extracellular domain arginine methylation regulates EGFR function.	Arginine	42-50	epidermal growth factor receptor	Canis lupus familiaris	73-77
26519531-7	2015	In this study, we demonstrate that the leucine-rich hydrophobic sequence stretches (with the central leucine residues L20 and L66) in the first and second TM helix of TAP2 form a functional unit acting as a docking site for optimal TPN/MHC I recruitment, whereas three distinct highly conserved arginine and/or aspartate residues inside or flanking these TM helices are dispensable.	Arginine	295-303	TAP binding protein	Homo sapiens	232-235
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-34	nitric oxide synthase 2, inducible	Mus musculus	94-98
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-29	nitric oxide synthase 2, inducible	Mus musculus	79-92
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-29	nitric oxide synthase 2, inducible	Mus musculus	94-98
26491198-9	2015	The abrogation of suppressive function is due to low intracellular l-Arg levels, which leads to the impaired ability of NOS2 to catalyze l-Arg-dependent metabolic processes.	Arginine	67-72	nitric oxide synthase 2, inducible	Mus musculus	120-124
26491198-9	2015	The abrogation of suppressive function is due to low intracellular l-Arg levels, which leads to the impaired ability of NOS2 to catalyze l-Arg-dependent metabolic processes.	Arginine	137-142	nitric oxide synthase 2, inducible	Mus musculus	120-124
26577684-3	2015	Transfection of HA-PEI/pDNA-IL4 and HA-PEI/pDNA-IL10 NPs increased IL4 and IL10 gene expression in J774 macrophages which could re-program the macrophages from M1 to M2 phenotype as evidenced by a significant increase in the Arg/iNOS level, and upregulation of CD206 and CD163 compared to untreated macrophages.	Arginine	225-228	interleukin 10	Mus musculus	48-52
26482848-4	2015	Using peptide mass fingerprinting, we identified protein arginine N-methyltransferase 5 (PRMT5), a type II protein arginine N-methyltransferase that monomethylates and symmetrically dimethylates arginine residues, as a novel protein that interacts with RASSF1A.	Arginine	57-65	protein arginine methyltransferase 5	Homo sapiens	89-94
26577684-5	2015	In an in vivo model of stimulated peritoneal macrophages, IP administration of HA-PEI/pDNA-IL4 and HA-PEI/pDNA-IL10 to C57BL/6 mice significantly increased the Arg/iNOS ratio and CD163 expression in the cells.	Arginine	160-163	interleukin 10	Mus musculus	111-115
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Arginine	141-144	N-terminal Xaa-Pro-Lys N-methyltransferase 1	Homo sapiens	46-51
26463133-1	2015	The dual inhibitory action of the pain related peptide opiorphin (H-Gln-Arg-Phe-Ser-Arg-OH) against neutral endopeptidase (NEP) and aminopeptidase N (AP-N) was further investigated by a SAR study involving minor modifications on the polar side chains of Arg residues and glycosylation with monosaccharides at Ser.	Arginine	72-75	opiorphin prepropeptide	Homo sapiens	55-64
26463133-1	2015	The dual inhibitory action of the pain related peptide opiorphin (H-Gln-Arg-Phe-Ser-Arg-OH) against neutral endopeptidase (NEP) and aminopeptidase N (AP-N) was further investigated by a SAR study involving minor modifications on the polar side chains of Arg residues and glycosylation with monosaccharides at Ser.	Arginine	72-75	membrane metalloendopeptidase	Homo sapiens	100-121
26463133-1	2015	The dual inhibitory action of the pain related peptide opiorphin (H-Gln-Arg-Phe-Ser-Arg-OH) against neutral endopeptidase (NEP) and aminopeptidase N (AP-N) was further investigated by a SAR study involving minor modifications on the polar side chains of Arg residues and glycosylation with monosaccharides at Ser.	Arginine	72-75	membrane metalloendopeptidase	Homo sapiens	123-126
26643924-6	2015	In summary, this investigation provides new evidence on the effect of ZIP2 Gln/Arg/Leu polymorphism on proinflammatory mediators and zinc homeostasis in elderly population with a more pronounced anti-inflammatory effect of zinc supplementation in subjects carrying ZIP2 Leu- (Arg43Arg) genotype.	Arginine	79-82	solute carrier family 39 member 2	Homo sapiens	70-74
26386436-1	2015	In the immune system, macrophages in tumor tissue generate nitric oxide (NO), producing versatile effects including apoptosis of tumor cells, because inducible NO synthase (iNOS) in the cytoplasm of a macrophage produces NO using l-arginine as a substrate.	Arginine	230-240	nitric oxide synthase 2, inducible	Mus musculus	150-171
26386436-1	2015	In the immune system, macrophages in tumor tissue generate nitric oxide (NO), producing versatile effects including apoptosis of tumor cells, because inducible NO synthase (iNOS) in the cytoplasm of a macrophage produces NO using l-arginine as a substrate.	Arginine	230-240	nitric oxide synthase 2, inducible	Mus musculus	173-177
26386436-4	2015	iNOS treatment of PEG-b-P(l-Arg) did not generate NO, but NO molecules were detected after trypsin pretreatment, indicating that hydrolysis of P(l-Arg) to monomeric arginine was taking place in vitro.	Arginine	26-31	nitric oxide synthase 2, inducible	Mus musculus	0-4
26386436-4	2015	iNOS treatment of PEG-b-P(l-Arg) did not generate NO, but NO molecules were detected after trypsin pretreatment, indicating that hydrolysis of P(l-Arg) to monomeric arginine was taking place in vitro.	Arginine	165-173	nitric oxide synthase 2, inducible	Mus musculus	0-4
26312620-1	2015	PURPOSE: To report 2 cases of corneal perforation associated with a persistent epithelial defect (PED), which were treated with eye drops containing the fibronectin-derived peptide PHSRN (Pro-His-Ser-Arg-Asn).	Arginine	200-203	fibronectin 1	Homo sapiens	153-164
25966637-0	2015	Arg(1809) substitution in neurofibromin: further evidence of a genotype-phenotype correlation in neurofibromatosis type 1.	Arginine	0-3	neurofibromin 1	Homo sapiens	26-39
25966637-0	2015	Arg(1809) substitution in neurofibromin: further evidence of a genotype-phenotype correlation in neurofibromatosis type 1.	Arginine	0-3	neurofibromin 1	Homo sapiens	97-121
26277751-0	2015	Role of the salt bridge between glutamate 546 and arginine 907 in preservation of autoinhibited form of Apaf-1.	Arginine	50-58	apoptotic peptidase activating factor 1	Homo sapiens	104-110
26218495-1	2015	Though l-arginine-containing polymers show versatile biological functions, a precisely controlled synthesis of poly(ethylene glycol)-b-poly(l-arginine) (PEG-b-PArg) block copolymers has not been reported.	Arginine	7-17	poly(ADP-ribose) glycohydrolase	Homo sapiens	159-163
26342955-3	2015	This study investigates whether L-arginine (substrate for nitric oxide synthase (NOS) or endothelin-A receptor antagonist BQ123 administration reverses hypoxia-induced changes in perfusion pressure in the fetal compartment in dual-perfused placental cotyledons.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	58-79
26385052-0	2015	Pharmacogenetic influence of eNOS gene variant on endothelial and glucose metabolism responses to L-arginine supplementation: Post hoc analysis of the L-arginine trial.	Arginine	151-161	nitric oxide synthase 3	Homo sapiens	29-33
26385052-1	2015	OBJECTIVE: To evaluate whether variants of the eNOS gene are associated with endothelial and metabolic responses to L-arginine (L-arg) supplementation.	Arginine	116-126	nitric oxide synthase 3	Homo sapiens	47-51
26385052-1	2015	OBJECTIVE: To evaluate whether variants of the eNOS gene are associated with endothelial and metabolic responses to L-arginine (L-arg) supplementation.	Arginine	116-121	nitric oxide synthase 3	Homo sapiens	47-51
26385052-2	2015	MATERIAL AND METHODS: We examined a single nucleotide polymorphism of the eNOS gene (rs753482-A&gt;C) to investigate the effects of this variant on endothelial function (EF), colony-forming unit-endothelial cell (CFU-EC) number, asymmetric-dimethylarginine (ADMA) level, insulin sensitivity index (ISI), and insulin secretion (IS) in a post hoc analysis of the L-arg trial.	Arginine	361-366	nitric oxide synthase 3	Homo sapiens	74-78
26218495-7	2015	Thus, PIC micelles containing PArg are a potentially effective arginine carrier for the development of in vivo therapeutic applications for various diseases related to nitric oxide, which is generated from inducible nitric oxide synthase in macrophages using l-arginine as a substrate.	Arginine	63-71	poly(ADP-ribose) glycohydrolase	Homo sapiens	30-34
26218495-7	2015	Thus, PIC micelles containing PArg are a potentially effective arginine carrier for the development of in vivo therapeutic applications for various diseases related to nitric oxide, which is generated from inducible nitric oxide synthase in macrophages using l-arginine as a substrate.	Arginine	259-269	poly(ADP-ribose) glycohydrolase	Homo sapiens	30-34
26385052-0	2015	Pharmacogenetic influence of eNOS gene variant on endothelial and glucose metabolism responses to L-arginine supplementation: Post hoc analysis of the L-arginine trial.	Arginine	98-108	nitric oxide synthase 3	Homo sapiens	29-33
26202060-1	2015	BACKGROUND: Carboxypeptidase-D (CPD) cleaves C-terminal arginine for conversion to nitric oxide (NO) by nitric oxide synthase (NOS).	Arginine	56-64	nitric oxide synthase 2	Homo sapiens	104-125
26342079-4	2015	Our study maps the important ISD11 amino acid residues belonging to putative helix 1 (Phe-40), helix 3 (Leu-63, Arg-68, Gln-69, Ile-72, Tyr-76), and C-terminal segment (Leu-81, Glu-84) are critical for in vivo Fe-S cluster biogenesis.	Arginine	112-115	LYR motif containing 4	Homo sapiens	29-34
26497740-1	2015	BACKGROUND: Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens.	Arginine	63-73	nitric oxide synthase 2	Homo sapiens	12-43
26497740-1	2015	BACKGROUND: Inducible nitric oxide synthase (iNOS) metabolizes L-arginine to produce nitric oxide (NO) which was originally identified in myeloid cells as a host defense mechanism against pathogens.	Arginine	63-73	nitric oxide synthase 2	Homo sapiens	45-49
26318455-2	2015	The vast majority of Fn-integrin interactions are mediated through the Fn Arg-Gly-Asp (RGD) motif located within the tenth type III repeat.	Arginine	74-77	fibronectin 1	Homo sapiens	21-23
26488656-5	2015	Conservation of the arginine component of the ionic lock among Rhodopsin-like G-protein-coupled receptors suggests that intracellular lipid ingression between receptor helices H6 and H7 may be a general mechanism for active-state stabilization.	Arginine	20-28	rhodopsin	Homo sapiens	63-72
26318455-2	2015	The vast majority of Fn-integrin interactions are mediated through the Fn Arg-Gly-Asp (RGD) motif located within the tenth type III repeat.	Arginine	74-77	fibronectin 1	Homo sapiens	71-73
26499181-4	2015	In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite.	Arginine	53-63	nitric oxide synthase 3	Homo sapiens	78-111
26463841-4	2015	RESULTS: The administration of Arg either before or after IL significantly ameliorated uncontrolled elevation of TBARS content, CYP2E1 activity (0.32 +- 0.01 or 0.3 +- 0.02 IU/mg) and TNF-alpha level.	Arginine	31-34	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	128-134
26463841-4	2015	RESULTS: The administration of Arg either before or after IL significantly ameliorated uncontrolled elevation of TBARS content, CYP2E1 activity (0.32 +- 0.01 or 0.3 +- 0.02 IU/mg) and TNF-alpha level.	Arginine	31-34	tumor necrosis factor	Rattus norvegicus	184-193
26463841-7	2015	CONCLUSIONS: These results proved that pre- and post-treatment with Arg blocked oxidative stress-induced NASH by inhibiting CYP2E1 activity, decreasing TNF- alpha level and restoration activities of eNOS and antioxidant enzymes as well as glutathione level.	Arginine	68-71	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	124-130
26463841-7	2015	CONCLUSIONS: These results proved that pre- and post-treatment with Arg blocked oxidative stress-induced NASH by inhibiting CYP2E1 activity, decreasing TNF- alpha level and restoration activities of eNOS and antioxidant enzymes as well as glutathione level.	Arginine	68-71	tumor necrosis factor	Rattus norvegicus	152-162
25865156-10	2015	Combination of ISO and ARG led to a decrease in cav-1 expression, a further increase in MYH7 expression and a down-regulation of MYH6 that inversely correlated with gp91phox mRNA levels.	Arginine	23-26	caveolin 1	Rattus norvegicus	48-53
26147657-1	2015	In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (alpha-KG) to R-2-hydroxyglutarate (2-HG).	Arginine	142-150	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	61-65
26147657-1	2015	In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (alpha-KG) to R-2-hydroxyglutarate (2-HG).	Arginine	142-150	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	193-197
26664375-5	2015	The study showed that the p-SO2Me-phenyl fragment of 5e inserted inside secondary COX-2 binding site (Arg(513), Phe(518), Gly(519), and His(90)).	Arginine	102-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
25966956-8	2015	We observed decreased expression of the L-arg-sensitive CD3zeta on T cells, consistent with decreased functional activity.	Arginine	40-45	CD247 antigen	Mus musculus	56-63
26436589-0	2015	PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.	Arginine	78-86	protein arginine methyltransferase 6	Homo sapiens	0-5
26436589-0	2015	PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.	Arginine	78-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-47
26436589-0	2015	PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.	Arginine	78-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-53
26436589-2	2015	Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, resulting in the increase of cytoplasmic localization of p21.	Arginine	33-41	protein arginine methyltransferase 6	Homo sapiens	63-68
26436589-2	2015	Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, resulting in the increase of cytoplasmic localization of p21.	Arginine	33-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-84
26436589-2	2015	Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, resulting in the increase of cytoplasmic localization of p21.	Arginine	33-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-153
26436589-2	2015	Here we demonstrate that protein arginine methyltransferase 6 (PRMT6) methylates p21 at arginine 156 and promotes phosphorylation of threonine 145 on p21, resulting in the increase of cytoplasmic localization of p21.	Arginine	33-41	cyclin dependent kinase inhibitor 1A	Homo sapiens	150-153
26254336-5	2015	Analyzing antioxidant enzyme levels and activities, we found that ErbB2(tg) hearts have increased levels of glutathione peroxidase 1 (GPx1) protein (P &lt; 0.0001) and GPx activity (P = 0.0031) in addition to increased levels of two known GPx activators, c-Abl (P = 0.0284) and Arg (P &lt; 0.0001).	Arginine	278-281	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-75
25112958-4	2015	The enzymatic activity of PON1 against OPs depends on the genetic polymorphisms present at position 192 (glutamine or arginine).	Arginine	118-126	paraoxonase 1	Homo sapiens	26-30
26151339-2	2015	Protein arginine methyltransferase 5 (PRMT5) methylates arginines of Golgi components and other factors exerting diverse effects on cell growth/differentiation, but the underlying molecular basis for its subcellular distribution and diverse roles has not been fully understood.	Arginine	56-65	protein arginine methyltransferase 5	Homo sapiens	0-36
26151339-2	2015	Protein arginine methyltransferase 5 (PRMT5) methylates arginines of Golgi components and other factors exerting diverse effects on cell growth/differentiation, but the underlying molecular basis for its subcellular distribution and diverse roles has not been fully understood.	Arginine	56-65	protein arginine methyltransferase 5	Homo sapiens	38-43
26517932-4	2015	Studies carried out in several cultured cells clearly report that the TRIB3 Q84R missense polymorphism, is a gain-of-function amino acid substitution, with the Arg(84) variant being a stronger inhibitor of insulin-mediated AKT activation as compared with the more frequent Gln(84) variant.	Arginine	160-163	insulin	Homo sapiens	206-213
26517932-4	2015	Studies carried out in several cultured cells clearly report that the TRIB3 Q84R missense polymorphism, is a gain-of-function amino acid substitution, with the Arg(84) variant being a stronger inhibitor of insulin-mediated AKT activation as compared with the more frequent Gln(84) variant.	Arginine	160-163	AKT serine/threonine kinase 1	Homo sapiens	223-226
26517932-5	2015	Given the key role of AKT in modulating not only insulin signalling but also insulin secretion, it was not surprising that beta-cells and human pancreatic islets carrying the Arg(84) variant showed also impaired insulin secretion.	Arginine	175-178	AKT serine/threonine kinase 1	Homo sapiens	22-25
26517932-5	2015	Given the key role of AKT in modulating not only insulin signalling but also insulin secretion, it was not surprising that beta-cells and human pancreatic islets carrying the Arg(84) variant showed also impaired insulin secretion.	Arginine	175-178	insulin	Homo sapiens	49-56
26517932-5	2015	Given the key role of AKT in modulating not only insulin signalling but also insulin secretion, it was not surprising that beta-cells and human pancreatic islets carrying the Arg(84) variant showed also impaired insulin secretion.	Arginine	175-178	insulin	Homo sapiens	77-84
26517932-6	2015	Also, of note is that in human vein endothelial cells carrying the Arg(84) variant showed a reduced insulin-induced nitric oxide release, an established early atherosclerotic step.	Arginine	67-70	insulin	Homo sapiens	100-107
26517932-7	2015	Accordingly with in vitro studies, in vivo studies indicate that TRIB3 Arg(84) is associated with insulin resistance, T2DM and several aspects of atherosclerosis, including overt CVD.	Arginine	71-74	insulin	Homo sapiens	98-105
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Arginine	26-34	cyclin dependent kinase inhibitor 2A	Homo sapiens	63-66
26238930-1	2015	Previous studies have demonstrated that the alpha5beta1 integrin-mediated interaction with fibronectin (FN) occurs through the Arg-Gly-Asp (RGD) cell-binding sequence in repeat III10.	Arginine	127-130	fibronectin 1	Homo sapiens	91-102
26252573-4	2015	A single base mutation from cytosine to guanine at site 1582 was identified in exon 11 of CACNA1S in one FHPP pedigree, resulting in an arginine to glycine (R528G) substitution.	Arginine	136-144	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	90-97
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Arginine	26-34	cyclin dependent kinase inhibitor 2A	Homo sapiens	191-194
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Arginine	128-136	cyclin dependent kinase inhibitor 2A	Homo sapiens	63-66
26622834-3	2015	In the present study, the arginine 22, 131 and 138 residues of p16 were found to be methylation sites, as the mutation of these arginine residues to lysine resulted in the hypomethylation of p16.	Arginine	128-136	cyclin dependent kinase inhibitor 2A	Homo sapiens	191-194
26622834-4	2015	Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues.	Arginine	25-33	protein arginine methyltransferase 6	Homo sapiens	87-92
26622834-4	2015	Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues.	Arginine	25-33	cyclin dependent kinase inhibitor 2A	Homo sapiens	151-154
26622834-7	2015	Preliminarily, the crosstalk between the phosphorylation and arginine methylation modification of p16 was examined.	Arginine	61-69	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
26622834-8	2015	These findings predict a role for serine phosphorylation against arginine methylation of p16.	Arginine	65-73	cyclin dependent kinase inhibitor 2A	Homo sapiens	89-92
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	protein arginine methyltransferase 5	Homo sapiens	50-55
26428638-6	2015	L-arginine acts to increase the production of nitric oxide and Pycnogenol( ) activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	91-124
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	BCL2 associated X, apoptosis regulator	Homo sapiens	281-284
26374839-2	2015	FMRP uses an arginine-glycine-rich (RGG) motif for specific interactions with guanine (G)-quadruplexes, mRNA elements implicated in the disease-associated regulation of specific mRNAs.	Arginine	13-21	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
26252621-7	2015	The histidine residue binds heme, while the arginine and the tyrosine act as key second sphere residues of the heme-Abeta active site that play a crucial role in its reactivity.	Arginine	44-52	amyloid beta precursor protein	Homo sapiens	116-121
26420962-0	2015	TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.	Arginine	14-17	tumor protein p53	Homo sapiens	0-4
26420962-0	2015	TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.	Arginine	18-21	tumor protein p53	Homo sapiens	0-4
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Arginine	92-100	tumor protein p53	Homo sapiens	46-50
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Arginine	92-100	tumor protein p53	Homo sapiens	163-167
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Arginine	102-105	tumor protein p53	Homo sapiens	46-50
26420962-4	2015	A single nucleotide polymorphism (SNP) in the TP53 gene resulting in the presence of either arginine (Arg) or proline (Pro) or both at codon 72 was shown to alter TP53 tumor-suppressor properties.	Arginine	102-105	tumor protein p53	Homo sapiens	163-167
26420962-8	2015	RESULTS: The most frequent TP53 genotype in IBD patients was Arg/Arg occurring in 54%-64% of cases (and in only 32% of controls).	Arginine	61-64	tumor protein p53	Homo sapiens	27-31
26420962-8	2015	RESULTS: The most frequent TP53 genotype in IBD patients was Arg/Arg occurring in 54%-64% of cases (and in only 32% of controls).	Arginine	65-68	tumor protein p53	Homo sapiens	27-31
26420962-11	2015	CONCLUSION: The data suggests that the TP53 codon 72 Arg/Arg genotype is associated with increased risk for IBD development.	Arginine	53-56	tumor protein p53	Homo sapiens	39-43
26420962-11	2015	CONCLUSION: The data suggests that the TP53 codon 72 Arg/Arg genotype is associated with increased risk for IBD development.	Arginine	57-60	tumor protein p53	Homo sapiens	39-43
26407009-2	2015	Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an endogenous NO synthase (NOS) inhibitor, and arginine, the NOS substrate.	Arginine	8-16	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	41-45
26407009-2	2015	Dimethylarginine dimethylaminohydrolase (DDAH) regulates endothelial NO synthesis by maintaining homeostasis between asymmetric dimethylarginine (ADMA), an endogenous NO synthase (NOS) inhibitor, and arginine, the NOS substrate.	Arginine	8-16	nitric oxide synthase 2	Homo sapiens	167-178
26203187-4	2015	Here we show that substitution of a conserved positively charged residue (Arg-388, hEAAT1) in transmembrane domain 7 with a negatively charged amino acid eliminates the ability of glutamate to further activate the anion conductance.	Arginine	74-77	solute carrier family 1 member 3	Homo sapiens	83-89
26203187-9	2015	Our data provide additional insights into the mechanism by which substrates gate the anion conductance in EAATs and suggest that in EAAT1, Arg-388 is a critical element for the structural coupling between the substrate translocation and the gating mechanisms of the EAAT-associated anion channel.	Arginine	139-142	solute carrier family 1 member 3	Homo sapiens	132-137
26337909-5	2015	Recent evidence from our laboratories and others indicates that, in addition to various posttranslational modifications of NF-kappaB that have been observed previously, including phosphorylation, ubiquitination, and acetylation, NF-kappaB can be methylated reversibly on lysine or arginine residues by histone-modifying enzymes, including lysine and arginine methyl transferases and demethylases.	Arginine	281-289	nuclear factor kappa B subunit 1	Homo sapiens	123-132
26199422-3	2015	In the crystal structure, the cleavage site (P1-P1") of the vaspin reactive centre loop is fairly rigid compared with the flexible residues before P2, possibly supported by an ionic interaction of P1" glutamate (Glu(379)) with an arginine residue (Arg(302)) of the beta-sheet C. A P1" glutamate seems highly unusual and unfavourable for the protease KLK7.	Arginine	230-238	serpin family A member 12	Homo sapiens	60-66
26199422-3	2015	In the crystal structure, the cleavage site (P1-P1") of the vaspin reactive centre loop is fairly rigid compared with the flexible residues before P2, possibly supported by an ionic interaction of P1" glutamate (Glu(379)) with an arginine residue (Arg(302)) of the beta-sheet C. A P1" glutamate seems highly unusual and unfavourable for the protease KLK7.	Arginine	248-251	serpin family A member 12	Homo sapiens	60-66
26199422-6	2015	Arg(302) is a crucial contact to enable vaspin recognition by KLK7 and it supports moderate inhibition of the serpin despite the presence of the detrimental P1" Glu(379), which clearly represents a major limiting factor for vaspin-inhibitory activity.	Arginine	0-3	serpin family A member 12	Homo sapiens	40-46
26199422-6	2015	Arg(302) is a crucial contact to enable vaspin recognition by KLK7 and it supports moderate inhibition of the serpin despite the presence of the detrimental P1" Glu(379), which clearly represents a major limiting factor for vaspin-inhibitory activity.	Arginine	0-3	serpin family A member 12	Homo sapiens	224-230
26337909-5	2015	Recent evidence from our laboratories and others indicates that, in addition to various posttranslational modifications of NF-kappaB that have been observed previously, including phosphorylation, ubiquitination, and acetylation, NF-kappaB can be methylated reversibly on lysine or arginine residues by histone-modifying enzymes, including lysine and arginine methyl transferases and demethylases.	Arginine	281-289	nuclear factor kappa B subunit 1	Homo sapiens	229-238
26078354-11	2015	Collectively, our findings provide new evidence that PRMT5 plays an important role in CRC pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E and FGFR3.	Arginine	137-145	protein arginine methyltransferase 5	Homo sapiens	53-58
25628417-6	2015	Therefore, we hypothesize that the decrease in CBS expression in the RVLM may be involved in the disorder of l-arginine/NO pathway, which subsequently affects BP in SHR.	Arginine	109-119	cystathionine beta synthase	Rattus norvegicus	47-50
25990963-6	2015	Presence of arginine residues in the carrier peptide proved to be a prerequisite for complexation with insulin as well as for enhanced transepithelial insulin permeation in vitro.	Arginine	12-20	insulin	Homo sapiens	103-110
25990963-6	2015	Presence of arginine residues in the carrier peptide proved to be a prerequisite for complexation with insulin as well as for enhanced transepithelial insulin permeation in vitro.	Arginine	12-20	insulin	Homo sapiens	151-158
26055922-4	2015	In the present study, we measured the concentrations of the nitric oxide (NO) metabolites nitrate and nitrite, the endogenous substrates of NO synthase (NOS) L-arginine (Arg) and L-homoarginine (hArg), and asymmetric dimethylarginine (ADMA), the endogenous inhibitor of NOS activity, in the serum and cerebrospinal fluid (CSF) of patients with MS, NMO or other neurologic diseases (OND).	Arginine	158-168	nitric oxide synthase 2	Homo sapiens	140-151
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	368-371	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	247-255	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	257-260	tumor protein p53	Homo sapiens	40-43
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	368-371	tumor protein p53	Homo sapiens	40-43
26303972-6	2015	The amino-terminal Arg of BiP binds p62, which triggers p62 oligomerization and enhances p62-LC3 interaction, thereby stimulating autophagic delivery and degradation of misfolded proteins, promoting cell survival.	Arginine	19-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	26-29
26617937-6	2015	Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Treponema denticola possess the PAD enzyme, and p53 arginine mutations have been detected in patients with pancreatic cancer.	Arginine	127-135	tumor protein p53	Homo sapiens	123-126
25772817-9	2015	The molecular explanation of lower serum SDMA is unclear, but the established relationships with indices of disease activity and insulin resistance, may underline the pathogenetic role of the L-arginine/NO pathway dysregulation in the development of atherosclerosis in RA.	Arginine	192-202	insulin	Homo sapiens	129-136
25979114-5	2015	Emerging evidence suggests that two key post-translational modifications of polyglutamine-expanded androgen receptor, namely serine phosphorylation by protein kinase B/Akt and arginine methylation by protein arginine methyltransferases, occur at the same consensus site, are mutually exclusive, and have opposing effects on neurotoxicity.	Arginine	176-184	androgen receptor	Homo sapiens	99-116
25979114-5	2015	Emerging evidence suggests that two key post-translational modifications of polyglutamine-expanded androgen receptor, namely serine phosphorylation by protein kinase B/Akt and arginine methylation by protein arginine methyltransferases, occur at the same consensus site, are mutually exclusive, and have opposing effects on neurotoxicity.	Arginine	208-216	androgen receptor	Homo sapiens	99-116
26617937-9	2015	The hypothesis in question can be tested if the DNA of P. gingivalis or the antibodies against P. gingivalis can be detected in patients with the p53 arginine mutation.If this hypothesis is true, it could reveal the real cause of pancreatic cancer, which is a fatal disease.	Arginine	150-158	tumor protein p53	Homo sapiens	146-149
26086249-1	2015	The protein arginine methyltransferase 5 (PRMT5) controls cell growth and apoptosis by catalyzing mono and symmetric dimethylation of arginine residues.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	42-47
26179100-2	2015	The genetic basis has been identified as a cytosine to thymine mutation in the CWC15 gene that changes an amino acid from arginine to a stop code.	Arginine	122-130	CWC15 spliceosome associated protein homolog	Bos taurus	79-84
26178996-6	2015	We mapped the PRMT6 interaction motif to the pUL69 N terminus and identified critical amino acids within the arginine-rich R1 box of pUL69 that were crucial for PRMT6 and/or UAP56 recruitment.	Arginine	109-117	protein arginine methyltransferase 6	Homo sapiens	14-19
26178996-6	2015	We mapped the PRMT6 interaction motif to the pUL69 N terminus and identified critical amino acids within the arginine-rich R1 box of pUL69 that were crucial for PRMT6 and/or UAP56 recruitment.	Arginine	109-117	protein arginine methyltransferase 6	Homo sapiens	161-166
26178996-8	2015	Thus, we were able to discriminate between arginines within the R1 box of pUL69 that were crucial for UAP56/PRMT6-interaction and/or mRNA export activity.	Arginine	43-52	protein arginine methyltransferase 6	Homo sapiens	108-113
26178996-13	2015	Furthermore, arginine residues with a crucial function for RNA export and for binding of the cellular RNA export factor UAP56 as well as PRMT6 were mapped within the arginine-rich R1 motif of pUL69.	Arginine	166-174	protein arginine methyltransferase 6	Homo sapiens	137-142
26160175-6	2015	TG2 residues Arg-116 and His-134 were identified to be critical for binding of 679-14-E06 as well as other epitope 1 antibodies.	Arginine	13-16	transglutaminase 2	Homo sapiens	0-3
26047835-6	2015	The levels of 17beta-estradiol and the activities of alkaline phosphatase (ALP) were significantly increased by PPE or Arg in the serum of OVX mice.	Arginine	119-122	alkaline phosphatase, placental	Homo sapiens	75-78
26047835-9	2015	Finally, PPE or Arg increased the activations of ALP and extracellular signal-regulated kinase 1/2 in the MG-63 cells.	Arginine	16-19	alkaline phosphatase, placental	Homo sapiens	49-52
26047835-9	2015	Finally, PPE or Arg increased the activations of ALP and extracellular signal-regulated kinase 1/2 in the MG-63 cells.	Arginine	16-19	mitogen-activated protein kinase 3	Homo sapiens	57-98
26425661-3	2015	Recent studies suggest that PRMT5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin D1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis.	Arginine	152-160	protein arginine methyltransferase 5	Homo sapiens	28-33
26425661-3	2015	Recent studies suggest that PRMT5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin D1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis.	Arginine	152-160	tumor protein p53	Homo sapiens	138-141
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Arginine	93-96	amyloid beta precursor protein	Homo sapiens	192-196
26062636-10	2015	GO-6976 (PKCalpha inhibitor) prevented the progesterone-induced decrease in arginine transport.	Arginine	76-84	protein kinase C alpha	Homo sapiens	9-17
26336611-6	2015	The C peptide immunoreactivity (CPR) responses after arginine were diminished in both groups.	Arginine	53-61	cytochrome p450 oxidoreductase	Homo sapiens	32-35
26313940-3	2015	We hypothesized that L-arginine (L-Arg) precursor of NO-synthase (NOS) and asymmetric dimethylarginine (ADMA), an inhibitor of NOS, are present in PF of cardiac patients and their altered levels may contribute to altered cardiac morphology.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	53-64
26313940-3	2015	We hypothesized that L-arginine (L-Arg) precursor of NO-synthase (NOS) and asymmetric dimethylarginine (ADMA), an inhibitor of NOS, are present in PF of cardiac patients and their altered levels may contribute to altered cardiac morphology.	Arginine	33-38	nitric oxide synthase 2	Homo sapiens	53-64
26170455-8	2015	Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3).	Arginine	95-98	C-type lectin domain family 18 member A	Homo sapiens	10-16
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	Arginine	25-28	C-type lectin domain family 18 member A	Homo sapiens	14-21
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	Arginine	25-28	C-type lectin domain family 18 member A	Homo sapiens	35-42
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	Arginine	25-28	C-type lectin domain family 18 member A	Homo sapiens	35-42
26170455-9	2015	The Ser(339) (CLEC18A)   Arg(339) (CLEC18A-1) mutation completely abolishes CLEC18A-1 binding to GLPS-F3, and a sugar competition assay shows that CLEC18 preferentially binds to fucoidan, beta-glucans, and galactans.	Arginine	25-28	C-type lectin domain family 18 member A	Homo sapiens	14-20
26286023-1	2015	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease.	Arginine	69-79	nitric oxide synthase 3	Homo sapiens	0-33
26286023-1	2015	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease.	Arginine	69-79	nitric oxide synthase 3	Homo sapiens	35-39
26100624-8	2015	These results directly demonstrate that the interface for GCAP binding on RetGC1 requires not only the kinase homology region but also directly involves the dimerization domain and especially its portion containing Arg(822) and Met(823).	Arginine	215-218	guanylate cyclase activator 1A	Homo sapiens	58-62
26149688-0	2015	Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome.	Arginine	54-62	paired box 3	Homo sapiens	11-15
26149688-5	2015	Moreover, loading of PAX3 on mitotic chromosomes requires arginine methylation, which is regulated by methyltransferase PRMT5 and demethylase JMJD6.	Arginine	58-66	paired box 3	Homo sapiens	21-25
26149688-5	2015	Moreover, loading of PAX3 on mitotic chromosomes requires arginine methylation, which is regulated by methyltransferase PRMT5 and demethylase JMJD6.	Arginine	58-66	protein arginine methyltransferase 5	Homo sapiens	120-125
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Arginine	288-291	transmembrane serine protease 6	Homo sapiens	179-186
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Arginine	288-291	transmembrane serine protease 6	Homo sapiens	190-202
26051280-0	2015	The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis.	Arginine	17-20	vascular endothelial growth factor A	Homo sapiens	42-46
26059749-0	2015	Unaltered ratio of circulating levels of growth hormone/GH isoforms in adults with Prader-Willi syndrome after GHRH plus arginine administration.	Arginine	121-129	growth hormone 1	Homo sapiens	41-55
26247205-3	2015	Our data demonstrate that ATC has potent insulin-releasing properties, due to the additive action of its two components; thiazolidine carboxylate (TC) and L-arginine.	Arginine	155-165	insulin	Homo sapiens	41-48
26247205-5	2015	L-arginine serves as the substrate for NO synthase (NOS), which results in cADPR synthesis via cGMP formation.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	39-50
25953850-8	2015	Arg(432) and Arg(434) in domain V of MARCO are required for the polarization of macrophages to a profibrotic phenotype as mutation of these residues reduced FIZZ1 expression (17-fold) compared with cells expressing MARCO.	Arginine	0-3	resistin like alpha	Mus musculus	157-162
26063599-1	2015	HLA-A alleles are characterized by tandem arginine and histidine/arginine motifs (i.e., R65 and H151R motifs) present on the alpha1- and alpha2-helix, respectively.	Arginine	42-50	major histocompatibility complex, class I, A	Homo sapiens	0-5
26063599-1	2015	HLA-A alleles are characterized by tandem arginine and histidine/arginine motifs (i.e., R65 and H151R motifs) present on the alpha1- and alpha2-helix, respectively.	Arginine	65-73	major histocompatibility complex, class I, A	Homo sapiens	0-5
26059749-0	2015	Unaltered ratio of circulating levels of growth hormone/GH isoforms in adults with Prader-Willi syndrome after GHRH plus arginine administration.	Arginine	121-129	growth hormone 1	Homo sapiens	56-58
26271664-7	2015	The purified ArgJ was highly active in NAO deacetylation/glutamate transacetylation and was significantly inhibited by ornithine but not by arginine.	Arginine	140-148	bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ	Sinorhizobium meliloti 1021	13-17
26026257-1	2015	BACKGROUND: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis.	Arginine	63-71	nitric oxide synthase 2	Homo sapiens	12-33
25277268-5	2015	Patch clamp current recordings show that a rise in [Cl(-)]o stimulates CFTR channel activity, an effect conferred by a single arginine residue, R899, in extracellular loop 4 of the protein.	Arginine	126-134	CF transmembrane conductance regulator	Homo sapiens	71-75
25891130-2	2015	ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain.	Arginine	46-49	ADAM metallopeptidase domain 15	Homo sapiens	0-6
26026257-1	2015	BACKGROUND: Nitric oxide synthase (NOS) mediated conversion of arginine (ARG) to citrulline (CIT) is a key pathway for nitric oxide synthesis.	Arginine	73-76	nitric oxide synthase 2	Homo sapiens	12-33
25953061-1	2015	Physical training decreases glucose- and arginine-stimulated insulin secretion.	Arginine	41-49	insulin	Homo sapiens	61-68
27026770-5	2016	The sequence analysis revealed c.241 adenine (A)&gt;thymine (T) [p. arginine (Arg) 81 Tryptophan (Trp)] alteration in exon-3 of the TBX5 gene in affected family members and fetus.	Arginine	68-76	T-box transcription factor 5	Homo sapiens	132-136
26068400-4	2015	The Phe(5/8) and Arg(9) residues of BK generally participated in the interactions with colloidal suspended Ag surfaces.	Arginine	17-20	kininogen 1	Homo sapiens	36-38
27026770-5	2016	The sequence analysis revealed c.241 adenine (A)&gt;thymine (T) [p. arginine (Arg) 81 Tryptophan (Trp)] alteration in exon-3 of the TBX5 gene in affected family members and fetus.	Arginine	78-81	T-box transcription factor 5	Homo sapiens	132-136
25978582-1	2015	Nitric oxide (NO) is a key immune defense agent that is produced from l-arginine in the airways by leukocytes and airway epithelial cells, primarily via inducible nitric oxide synthase (iNOS).	Arginine	70-80	nitric oxide synthase 2, inducible	Mus musculus	153-184
26451317-8	2015	Blocking transforming growth factor beta (TGFbeta) or inducible nitric oxide synthase (iNOS) significantly abolished the T-MDSC-induced upregulation of COX-2 and EMT scores in NPC cells, whereas the administration of TGFbeta or L-arginine supplements upregulated COX-2 expression and EMT scores in NPC cells.	Arginine	228-238	nitric oxide synthase 2	Homo sapiens	54-85
26451317-8	2015	Blocking transforming growth factor beta (TGFbeta) or inducible nitric oxide synthase (iNOS) significantly abolished the T-MDSC-induced upregulation of COX-2 and EMT scores in NPC cells, whereas the administration of TGFbeta or L-arginine supplements upregulated COX-2 expression and EMT scores in NPC cells.	Arginine	228-238	nitric oxide synthase 2	Homo sapiens	87-91
26029979-2	2015	Here, we designed a histidylated arginine-grafted bioreducible polymer (HABP) as a nonviral gene carrier using different ratios of histidine and arginine-grafted bioreducible poly(cystaminebis(acrylamide)-diaminohexane) (poly(CBA-DAH)), known as ABP, to increase cellular uptake and endosomal escape efficiency.	Arginine	33-41	glutamate receptor interacting protein 2	Rattus norvegicus	73-76
25978582-1	2015	Nitric oxide (NO) is a key immune defense agent that is produced from l-arginine in the airways by leukocytes and airway epithelial cells, primarily via inducible nitric oxide synthase (iNOS).	Arginine	70-80	nitric oxide synthase 2, inducible	Mus musculus	186-190
25960296-3	2015	GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin alpha subtypes (alpha1, alpha2 and alpha4).	Arginine	57-65	tripartite motif containing 28	Homo sapiens	71-77
25979344-1	2015	Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA.	Arginine	14-22	splicing factor 3b subunit 2	Homo sapiens	114-119
25979344-1	2015	Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA.	Arginine	14-22	splicing factor 3b subunit 2	Homo sapiens	121-127
25979344-3	2015	In contrast to what had been observed with other PRMTs and their physiological substrates, a peptide containing the methylatable Arg-508 of SF3B2 was not recognized by PRMT9 in vitro.	Arginine	129-132	splicing factor 3b subunit 2	Homo sapiens	140-145
26075355-4	2015	R-BiP binds the autophagic adaptor p62 through the interaction of its N-terminal arginine with the p62 ZZ domain.	Arginine	81-89	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-5
26034040-12	2015	USF1 complexes containing the histone H3 asymmetrically dimethylated on Arg-17 signature of PRMT4 are increased with LRP6-VKO.	Arginine	72-75	upstream transcription factor 1	Mus musculus	0-4
26211584-9	2015	Our investigation has identified the residue Arg 105 to be more frequently involved in drug binding to CYP3A4.	Arginine	45-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-109
26095298-5	2015	Most influenza virus strains contain a HA sequence with a single arginine at the cleavage site suitable for processing by the trypsin-like serine proteases human airway trypsin-like protease (HAT) and transmembrane protease serine 2 (TMPRSS2), albeit a minority of viruses possesses HA cleavage site motifs that are processed by other proteases.	Arginine	65-73	transmembrane serine protease 2	Homo sapiens	201-232
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Arginine	25-28	tumor protein p53	Homo sapiens	48-51
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Arginine	29-32	tumor protein p53	Homo sapiens	48-51
25232917-8	2015	Patients with homozygous Arg/arg at codon 72 of P53 had a better median OS months than Arg/Pro and Pro/Pro (13.4 vs. 8.4 vs. 1.5 months, respectively; P = 0.045).	Arginine	87-90	tumor protein p53	Homo sapiens	48-51
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	208-211	tumor protein p53	Homo sapiens	0-3
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	289-292	tumor protein p53	Homo sapiens	0-3
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	289-292	tumor protein p53	Homo sapiens	0-3
26100532-11	2015	CONCLUSIONS: L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity.	Arginine	79-89	interleukin 6	Mus musculus	145-149
25940993-5	2015	rs1059449-A, which encodes arginine (R) at codon 56 of alpha1-helix of HLA-A protein, was postulated to be crucial for such a pattern of negative association with NPC.	Arginine	27-35	major histocompatibility complex, class I, A	Homo sapiens	71-76
25723054-2	2015	It was reported that obesity causes some variations on the serum levels of fetuin-A and is associated with arginine metabolism, especially arginase-1 levels.	Arginine	107-115	alpha 2-HS glycoprotein	Homo sapiens	75-83
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Arginine	47-50	tumor protein p53	Homo sapiens	43-46
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Arginine	136-139	tumor protein p53	Homo sapiens	43-46
26123760-10	2015	However, a significant association between p53 Arg72Pro polymorphism and the risk of oral cancer with HPV infection was detected in the Arg/Arg vs. Arg/Pro + Pro/Pro model.	Arginine	136-139	tumor protein p53	Homo sapiens	43-46
26024338-7	2015	In addition, our data support the idea that the positively charged arginine at position 303 poses a pure electrostatic action in determining the single-channel current amplitude of CFTR and the effect of an open-channel blocker glibencalmide.	Arginine	67-75	CF transmembrane conductance regulator	Homo sapiens	181-185
25898270-3	2015	Herein, we report AGRP-derived peptides designed to mimic the active beta-hairpin secondary structure that contains the hypothesized Arg-Phe-Phe pharmacophore.	Arginine	133-136	agouti related neuropeptide	Mus musculus	18-22
26070945-9	2015	RESULTS: Pretreatment of mice with L-Arg significantly increased the transcript level of iNOS in spleen cells and the amount of NO synthesized.	Arginine	35-40	nitric oxide synthase 2, inducible	Mus musculus	89-93
25662273-2	2015	The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1, Skb1, Capsuleen, or Dart5) is the major enzyme responsible for mono- and symmetric dimethylation of arginine.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	42-47
26240838-5	2015	Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres.	Arginine	72-75	microtubule-associated protein 2	Mus musculus	239-271
25248562-6	2015	Moreover, the Erk-mediated metastatic action was abolished by the mutation of leucine into arginine within the heptad leucine repeat region, which affects protein-protein interactions.	Arginine	91-99	mitogen-activated protein kinase 1	Homo sapiens	14-17
25934150-6	2015	Furthermore, treatment with insulin increased histone 3 methylation at arginine 17 and 26 in HepG2 cells.	Arginine	71-79	insulin	Homo sapiens	28-35
25662273-2	2015	The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1, Skb1, Capsuleen, or Dart5) is the major enzyme responsible for mono- and symmetric dimethylation of arginine.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	69-73
25662273-2	2015	The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1, Skb1, Capsuleen, or Dart5) is the major enzyme responsible for mono- and symmetric dimethylation of arginine.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	75-79
25346517-10	2015	The study demonstrated that immobilization of amino acids (Glu and Arg) on the surface of HA promoted osteoblast proliferation and ALP activity.	Arginine	67-70	alkaline phosphatase, placental	Homo sapiens	131-134
24865414-7	2015	Biochemical analyses revealed that ESBL producers more frequently utilized inositol, ornithine, sorbitol, melibiose, and saccharose, whereas the control group more frequently used esculin, lysine, arginine, and dulcitol.	Arginine	197-205	EsbL	Escherichia coli	35-39
25855119-10	2015	ICR mice showed at least a 2-fold greater expression (P &lt; 0.001) of ornithine transcarbamylase (OTC) than BL6 mice, which translated into a greater rate of citrulline (25%) and arginine synthesis (49%, P &lt; 0.002).	Arginine	180-188	ornithine transcarbamylase	Mus musculus	71-97
25216787-1	2015	Nitric oxide (NO) is a gas with biological and regulatory properties, produced from arginine by the way of nitric oxide synthases (NOS), and with a very short half-life (few seconds).	Arginine	84-92	nitric oxide synthase 2	Homo sapiens	107-129
25855119-10	2015	ICR mice showed at least a 2-fold greater expression (P &lt; 0.001) of ornithine transcarbamylase (OTC) than BL6 mice, which translated into a greater rate of citrulline (25%) and arginine synthesis (49%, P &lt; 0.002).	Arginine	180-188	ornithine transcarbamylase	Mus musculus	99-102
25855119-13	2015	CONCLUSION: Our data indicate that a reduced expression of OTC in BL6 mice translates into a reduced production of citrulline and arginine compared with ICR mice, which results in a dietary arginine requirement for growth in BL6 mice, but not in ICR mice.	Arginine	130-138	ornithine transcarbamylase	Mus musculus	59-62
25855119-13	2015	CONCLUSION: Our data indicate that a reduced expression of OTC in BL6 mice translates into a reduced production of citrulline and arginine compared with ICR mice, which results in a dietary arginine requirement for growth in BL6 mice, but not in ICR mice.	Arginine	190-198	ornithine transcarbamylase	Mus musculus	59-62
26035101-0	2015	Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations.	Arginine	56-64	protein arginine methyltransferase 5	Homo sapiens	113-118
25733201-7	2015	Moreover, insulin sensitizer therapy significantly reduced three functionally clustered AA and metabolite pairs: i) phenylalanine/tyrosine, ii) citrulline/arginine, and iii) lysine/alpha-aminoadipic acid.	Arginine	155-163	insulin	Homo sapiens	10-17
25862457-6	2015	ICP55 also removed single amino acids from mitochondrial proteins known to be cleaved at nonconserved arginine sites, a subset of mitochondrial proteins specific to plants.	Arginine	102-110	aminopeptidase	Saccharomyces cerevisiae S288C	0-5
25961538-2	2015	L-Arginine (Arg) confers a cytoprotective effect on lipopolysaccharide (LPS)-treated enterocytes through activation of the mammalian target of the rapamycin (mTOR) signaling pathway.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	158-162
25961538-2	2015	L-Arginine (Arg) confers a cytoprotective effect on lipopolysaccharide (LPS)-treated enterocytes through activation of the mammalian target of the rapamycin (mTOR) signaling pathway.	Arginine	2-5	mechanistic target of rapamycin kinase	Homo sapiens	158-162
25534683-2	2015	METHODS: Arginine, cysteine, and histidine modified trimethyl chitosan were synthesized and employed to self-assemble with plasmid DNA (pDNA) to form nanocomplexes, namely TRNC, TCNC, and THNC, respectively.	Arginine	9-17	mitochondrially encoded tRNA cysteine	Homo sapiens	172-176
25862457-5	2015	Monitoring of amino-terminal peptides showed that Arabidopsis ICP55 was responsible for the removal of single amino acids, and its action explained the -3 arginine processing motif of a number of mitochondrial proteins.	Arginine	155-163	aminopeptidase	Saccharomyces cerevisiae S288C	62-67
26035101-7	2015	Moreover, our results show that PRMT5 has an energetic preference for the first methylation on Neta1 followed by the second methylation on a different omega-guanidino nitrogen of arginine (Neta2).The first and second methyl transfers are estimated to have free energy barriers of 19-20 and 18-19 kcal/mol respectively.	Arginine	179-187	protein arginine methyltransferase 5	Homo sapiens	32-37
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	67-75	twist family bHLH transcription factor 1	Homo sapiens	103-109
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	67-75	cadherin 1	Homo sapiens	156-166
25851901-1	2015	Protein arginine methyltransferase 5 (PRMT5) is a key epigenetic regulator that symmetrically dimethylates arginine residues on histones H3 and H4 to silence gene expression.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	80-83	twist family bHLH transcription factor 1	Homo sapiens	103-109
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	80-83	cadherin 1	Homo sapiens	156-166
25851901-9	2015	We further show that PKCdelta/p38delta signaling suppresses MEP50 expression, leading to reduced H3/H4 arginine dimethylation at the p21(Cip1) promoter, and that this is associated with enhanced p21(Cip1) expression and reduced cell proliferation.	Arginine	103-111	mitogen-activated protein kinase 13	Homo sapiens	30-38
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	130-138	twist family bHLH transcription factor 1	Homo sapiens	103-109
25851901-9	2015	We further show that PKCdelta/p38delta signaling suppresses MEP50 expression, leading to reduced H3/H4 arginine dimethylation at the p21(Cip1) promoter, and that this is associated with enhanced p21(Cip1) expression and reduced cell proliferation.	Arginine	103-111	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-136
25851901-9	2015	We further show that PKCdelta/p38delta signaling suppresses MEP50 expression, leading to reduced H3/H4 arginine dimethylation at the p21(Cip1) promoter, and that this is associated with enhanced p21(Cip1) expression and reduced cell proliferation.	Arginine	103-111	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-141
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	130-138	cadherin 1	Homo sapiens	156-166
25847239-7	2015	Moreover, methylated Twist1 (Arg-34), as such, could also emerge as a potential important biomarker for lung cancer.	Arginine	29-32	twist family bHLH transcription factor 1	Homo sapiens	21-27
25172623-7	2015	Subgroup analysis of patients, however, demonstrated that the genotype C/C at position 1165 resulting in 389 Arg/Arg of the beta1 receptor was more frequent in women compared to those without FMV/MVP syndrome and to normal control women (p&lt;0.025).	Arginine	109-112	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	124-129
25973680-3	2015	We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carrying EGFP or TNF-related apoptosis-inducing ligand (TRAIL) gene (Onco(Ad).RGD-hTERT-EGFP/TRAIL), and applied them to CAR-negative bladder cancer T24 cells and cancer-initiating T24 sphere cells.	Arginine	15-18	TNF superfamily member 10	Homo sapiens	81-118
25973680-3	2015	We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carrying EGFP or TNF-related apoptosis-inducing ligand (TRAIL) gene (Onco(Ad).RGD-hTERT-EGFP/TRAIL), and applied them to CAR-negative bladder cancer T24 cells and cancer-initiating T24 sphere cells.	Arginine	15-18	TNF superfamily member 10	Homo sapiens	120-125
25973680-3	2015	We constructed Arg-Gly-Asp (RGD)-modified oncolytic adenovirus, carrying EGFP or TNF-related apoptosis-inducing ligand (TRAIL) gene (Onco(Ad).RGD-hTERT-EGFP/TRAIL), and applied them to CAR-negative bladder cancer T24 cells and cancer-initiating T24 sphere cells.	Arginine	15-18	TNF superfamily member 10	Homo sapiens	157-162
25744057-1	2015	Two isomeric piperidine derivatives (meta and para isomers) were used as arginine mimics in the P1 position of a cyclic peptidic inhibitor (CPAYSRYLDC) of urokinase-type plasminogen activator.	Arginine	73-81	plasminogen activator, urokinase	Homo sapiens	155-191
25996214-2	2015	NO is produced from l-arginine by constitutive NO synthase (NOS) and inducible NOS enzymatic pathways.	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	47-58
25945585-2	2015	The DYRK kinases are very unusual with respect to the sequence of the catalytic loop, in which the otherwise highly conserved arginine of the HRD motif is replaced by a cysteine.	Arginine	126-134	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	4-8
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Arginine	72-80	C-type lectin domain family 2 member A	Homo sapiens	9-13
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Arginine	72-80	C-type lectin domain family 2 member A	Homo sapiens	129-133
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Arginine	72-80	killer cell lectin like receptor F2	Homo sapiens	157-162
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Arginine	72-80	C-type lectin domain family 2 member A	Homo sapiens	129-133
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Arginine	0-8	C-type lectin domain family 2 member A	Homo sapiens	74-78
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Arginine	0-8	C-type lectin domain family 2 member A	Homo sapiens	139-143
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Arginine	0-8	killer cell lectin like receptor F2	Homo sapiens	144-149
25510854-10	2015	Arginine 158 and isoleucine 161 located at the membrane-distal surface of KACL were defined as residues, decisively determining functional KACL-NKp65 interaction that is independent of KACL glycosylation.	Arginine	0-8	C-type lectin domain family 2 member A	Homo sapiens	139-143
25172623-7	2015	Subgroup analysis of patients, however, demonstrated that the genotype C/C at position 1165 resulting in 389 Arg/Arg of the beta1 receptor was more frequent in women compared to those without FMV/MVP syndrome and to normal control women (p&lt;0.025).	Arginine	113-116	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	124-129
24983667-1	2015	OBJECTIVE: Nitric oxide (NO) formed by the enzyme NO synthase (NOS) from L-arginine, is an important mediator for pathogen elimination.	Arginine	73-83	nitric oxide synthase 2	Homo sapiens	50-61
25682972-17	2015	CONCLUSION: L-Arginine exerts its nephro- and cardio-protective potential in EG-induced urolithiasis in uninephrectomized hypertensive rats via modulation of KIM-1, NGAL, eNOS, and iNOs mRNA expression.	Arginine	12-22	nitric oxide synthase 2	Rattus norvegicus	181-185
25765074-8	2015	Expression of the protein arginine methyltransferase (PRMT) genes PRMT1, PRMT3 and PRMT5 throughout development was not affected by arginine.	Arginine	26-34	protein arginine methyltransferase 3	Homo sapiens	73-78
25690668-0	2015	von Willebrand factor arginine 1205 substitution results in accelerated macrophage-dependent clearance in vivo.	Arginine	22-30	von Willebrand factor	Homo sapiens	0-21
25680754-11	2015	Inhibition of pontin activity enhanced human receptor plasma membrane levels and signaling at 37 C. Our results demonstrate that human alpha2C-AR has a unique temperature-sensitive traffic pattern within the G protein-coupled receptor class due to interactions with different molecular chaperones, mediated in part by strict spatial localization of specific arginine residues.	Arginine	358-366	RuvB like AAA ATPase 1	Homo sapiens	14-20
25765074-7	2015	Embryos cultured in 1.69mM arginine had lower SLC7A1 levels and a higher abundance of messages involved with glycolysis (hexokinase 1, hexokinase 2 and glutamic pyruvate transaminase (alanine aminotransferase) 2) and decreased expression of genes involved with blocking the tricarboxylic acid cycle (pyruvate dehydrogenase kinase, isozyme 1) and the pentose phosphate pathway (transaldolase 1).	Arginine	27-35	hexokinase 1	Homo sapiens	121-133
25765074-8	2015	Expression of the protein arginine methyltransferase (PRMT) genes PRMT1, PRMT3 and PRMT5 throughout development was not affected by arginine.	Arginine	26-34	protein arginine methyltransferase 5	Homo sapiens	83-88
25621824-2	2015	PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine residues at ER binding sites.	Arginine	118-126	estrogen receptor 1	Homo sapiens	21-38
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Arginine	109-112	cadherin 1	Homo sapiens	68-72
25811913-1	2015	Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	0-21
25925198-6	2015	L-Arg treatment increased the population of CD4(+)T-bet(+)IFN-gamma(+) Th1 cells and the activated macrophages (F4/80(+)CD36(+)) in the spleen.	Arginine	0-5	interferon gamma	Homo sapiens	58-67
25925198-7	2015	The levels of pro-inflammatory cytokines, IFN-gamma and TNF-alpha, in splenocyte cultures were also increased by L-Arg treatment.	Arginine	113-118	interferon gamma	Homo sapiens	42-51
25925198-7	2015	The levels of pro-inflammatory cytokines, IFN-gamma and TNF-alpha, in splenocyte cultures were also increased by L-Arg treatment.	Arginine	113-118	tumor necrosis factor	Homo sapiens	56-65
25966185-9	2015	Similarly, the mEH Arg-allele was not associated with breast carcinoma risk based on the allelic contrast model (OR = 0.97, 95%CI = 0.91-1.04, P = 0.44), dominant genetic model (OR = 1.01, 95%CI = 0.84-1.21, P = 0.94), or recessive genetic model (OR = 1.04, 95%CI = 0.96-1.12, P = 0.35).	Arginine	19-22	epoxide hydrolase 1, microsomal	Mus musculus	15-18
25728001-1	2015	PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins.	Arginine	48-56	protein arginine methyltransferase 3	Homo sapiens	0-5
25742700-3	2015	EBV(+) lymphomas and transformed cell lines exhibited abundant expression of PRMT5, a type II PRMT enzyme that promotes transcriptional silencing of target genes by methylating arginine residues on histone tails.	Arginine	177-185	protein arginine methyltransferase 5	Homo sapiens	77-82
25889455-8	2015	In vitro experiments in cell lines indicated that enzymes controlling DNA methylation were differentially regulated by codon 72 Arg or Pro isoforms of p53.	Arginine	128-131	tumor protein p53	Homo sapiens	151-154
26131172-10	2015	Interestingly, in the subgroup analysis regarding P53 codon 72 polymorphism, increased HCC risk could be observed in the Pro/Pro+Pro/Arg subgroup under a recessive model (OR=1.78; 95% CI=1.29-2.44).	Arginine	133-136	tumor protein p53	Homo sapiens	50-53
25884909-6	2015	Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y(+)L-type amino acid transporter-1 (y(+)LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p &lt; 0.05).	Arginine	240-243	solute carrier family 2 member 2	Sus scrofa	72-98
25884909-6	2015	Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y(+)L-type amino acid transporter-1 (y(+)LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p &lt; 0.05).	Arginine	240-243	solute carrier family 2 member 2	Sus scrofa	100-106
25875935-12	2015	Vascular dysfunction caused by high D-glucose is likely attenuated by insulin through the L-arginine/NO and O2 -/NADPH oxidase pathways.	Arginine	90-100	insulin	Homo sapiens	70-77
25713080-11	2015	We propose a model in which MEP50 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site.	Arginine	112-120	protein arginine methyltransferase 5	Homo sapiens	38-43
25666610-8	2015	Recruitment of WDR5 to the midbody dark zone appears to require integrity of the WDR5 central arginine-binding cavity, as mutations that disrupt histone H3 and MLL1 binding to this pocket also abolish the midbody localization of WDR5.	Arginine	94-102	WD repeat domain 5	Homo sapiens	15-19
25666610-8	2015	Recruitment of WDR5 to the midbody dark zone appears to require integrity of the WDR5 central arginine-binding cavity, as mutations that disrupt histone H3 and MLL1 binding to this pocket also abolish the midbody localization of WDR5.	Arginine	94-102	WD repeat domain 5	Homo sapiens	81-85
25666610-8	2015	Recruitment of WDR5 to the midbody dark zone appears to require integrity of the WDR5 central arginine-binding cavity, as mutations that disrupt histone H3 and MLL1 binding to this pocket also abolish the midbody localization of WDR5.	Arginine	94-102	WD repeat domain 5	Homo sapiens	81-85
25608846-3	2015	The catalytic performance of iNOS is proposed to rely mainly on the haem midpoint potential and the ability of the substrate L-Arg to provide a hydrogen bond for oxygen activation (O-O scission).	Arginine	125-130	nitric oxide synthase 2	Homo sapiens	29-33
25887882-4	2015	The most widely and accurately described is the single nucleotide polymorphism, which impacts the conversion of glutamine (Q) to arginine (R) and has the effect of altering the hydrolytic activity of the PON1 form.	Arginine	129-137	paraoxonase 1	Homo sapiens	204-208
25838543-3	2015	To address these questions, we generated mice lacking the vertebrate- and neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4).	Arginine	94-97	serine/arginine repetitive matrix 4	Mus musculus	133-139
25838543-3	2015	To address these questions, we generated mice lacking the vertebrate- and neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4).	Arginine	94-97	serine/arginine repetitive matrix 4	Mus musculus	140-145
24728914-2	2015	We examined the concept that expression levels of endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil integrins Mac-1 and LFA-1 are modulated by the kinin B1 receptor (B1R) agonist, Lys-des[Arg(9)]bradykinin (LDBK).	Arginine	208-211	bradykinin receptor B1	Homo sapiens	186-189
25704252-10	2015	As assessed by in silico studies, we concluded that some arginines in the von Willebrand domain appear TMPRSS6 insensitive, likely because of partial protein structure destabilization.	Arginine	57-66	transmembrane serine protease 6	Homo sapiens	103-110
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Arginine	132-140	ADP-ribosyltransferase 1	Homo sapiens	32-61
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Arginine	132-140	ADP-ribosyltransferase 1	Homo sapiens	63-67
25128692-2	2015	Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which selectively transfers the ADP-ribose moiety from NAD to arginine residues, ADP-ribosylates LL-37 in vitro.	Arginine	132-140	cathelicidin antimicrobial peptide	Homo sapiens	167-172
25128692-4	2015	Mass-spectrometry showed that up to four of the five arginine residues present in LL-37 could be ADP-ribosylated on the same peptide when incubated at a high NAD concentration in the presence of ART1.	Arginine	53-61	cathelicidin antimicrobial peptide	Homo sapiens	82-87
25128692-4	2015	Mass-spectrometry showed that up to four of the five arginine residues present in LL-37 could be ADP-ribosylated on the same peptide when incubated at a high NAD concentration in the presence of ART1.	Arginine	53-61	ADP-ribosyltransferase 1	Homo sapiens	195-199
25128692-5	2015	The attachment of negatively charged ADP-ribose moieties considerably alters the positive charge of the arginine residues thus reducing the cationicity of LL-37.	Arginine	104-112	cathelicidin antimicrobial peptide	Homo sapiens	155-160
24939696-6	2015	Furthermore, mutation of Arg(205), which intercepts annexin 1-formyl peptide receptor binding, also decreased annexin 1 nuclear translocation.	Arginine	25-28	annexin A1	Rattus norvegicus	52-61
25745086-3	2015	Previously, we reported selective uptake of (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T::hB1R tumor xenografts in mice.	Arginine	81-84	bradykinin receptor, beta 1	Mus musculus	117-121
25745086-3	2015	Previously, we reported selective uptake of (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T::hB1R tumor xenografts in mice.	Arginine	81-84	bradykinin receptor, beta 1	Mus musculus	117-120
24939696-6	2015	Furthermore, mutation of Arg(205), which intercepts annexin 1-formyl peptide receptor binding, also decreased annexin 1 nuclear translocation.	Arginine	25-28	annexin A1	Rattus norvegicus	110-119
25577037-0	2015	Dual receptor-targeting 99mTc-labeled Arg-Gly-Asp-conjugated Alpha-Melanocyte stimulating hormone hybrid peptides for human melanoma imaging.	Arginine	38-41	proopiomelanocortin	Homo sapiens	61-97
25676786-11	2015	Arginine 493 is conserved among multiple species and all human nuclear receptors and its mutation has also been found in the human GR, androgen receptor, and mineralocorticoid receptor.	Arginine	0-8	androgen receptor	Homo sapiens	135-152
25694433-2	2015	beta1 integrins signal through the Abl2/Arg (Abl-related gene) nonreceptor tyrosine kinase to control fibroblast cell motility, neuronal dendrite morphogenesis and stability, and cancer cell invasiveness, but the molecular mechanisms by which integrin beta1 activates Arg are unknown.	Arginine	40-43	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-5
25615019-6	2015	Here, we describe the in vitro and in vivo characterization of such Las17 G-actin-binding motif (LGM) and its dependence on a group of conserved arginine residues.	Arginine	145-153	actin-binding protein LAS17	Saccharomyces cerevisiae S288C	68-73
25615019-6	2015	Here, we describe the in vitro and in vivo characterization of such Las17 G-actin-binding motif (LGM) and its dependence on a group of conserved arginine residues.	Arginine	145-153	actin	Saccharomyces cerevisiae S288C	76-81
25735747-6	2015	Moreover, the three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences.	Arginine	74-77	arginine repressor	Escherichia coli	20-24
25735747-6	2015	Moreover, the three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences.	Arginine	74-77	arginine repressor	Escherichia coli	192-196
25735747-6	2015	Moreover, the three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences.	Arginine	137-140	arginine repressor	Escherichia coli	20-24
25735747-6	2015	Moreover, the three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences.	Arginine	137-140	arginine repressor	Escherichia coli	192-196
25753662-6	2015	MBD2IDR also recruits the histone deacetylase core components (RbAp48, HDAC2 and MTA2) of NuRD through a critical contact region requiring two contiguous amino acid residues, Arg(286) and Leu(287).	Arginine	175-178	histone deacetylase 2	Homo sapiens	71-76
25451601-0	2015	Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.	Arginine	37-47	solute carrier family 38, member 8	Mus musculus	87-94
25451601-4	2015	We show that SLC38A8 has preference for transporting L-glutamine, L-alanine, L-arginine, L-histidine and L-aspartate using a Na+-dependent transport mechanism and that the functional characteristics of SNAT8 have highest similarity to the known System A transporters.	Arginine	77-87	solute carrier family 38, member 8	Mus musculus	13-20
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Arginine	24-27	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	122-127
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Arginine	151-154	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	122-127
25416280-2	2015	FMRP is a selective RNA binding protein owing to two central K-homology domains and a C-terminal arginine-glycine-glycine (RGG) box.	Arginine	97-105	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
25693919-1	2015	Herein, we design a label-free PET nanochannel for enantioselective recognition of Arg by adding bovine serum albumin (BSA) as chiral selector.	Arginine	83-86	albumin	Homo sapiens	104-117
25749046-6	2015	The underlying mechanism is complex, but increased DNA damage upon arginine deprivation due to decreased DNA repair proteins, FANCD2, ATM, and CHK1/2 most likely leads to increased apoptosis.	Arginine	67-75	checkpoint kinase 1	Homo sapiens	143-149
25807393-7	2015	We also identified important roles of a novel cluster of arginine residues in MAEL HMG-box in these interactions.	Arginine	57-65	maelstrom spermatogenic transposon silencer	Mus musculus	78-82
25805888-5	2015	We found that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; also known as PRMT4) methylated NICD at five conserved arginine residues within the C-terminal transactivation domain.	Arginine	66-74	coactivator-associated arginine methyltransferase 1	Danio rerio	36-41
25805888-5	2015	We found that the methyltransferase CARM1 (coactivator-associated arginine methyltransferase 1; also known as PRMT4) methylated NICD at five conserved arginine residues within the C-terminal transactivation domain.	Arginine	66-74	coactivator-associated arginine methyltransferase 1	Danio rerio	110-115
25774791-4	2015	RESULTS: The pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% CI = 1.55-1.99, Pheterogeneity = 0.075).	Arginine	104-107	tumor protein p53	Homo sapiens	100-103
26064201-1	2015	BACKGROUND: The polymorphism of TP53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer.	Arginine	73-76	tumor protein p53	Homo sapiens	32-36
26064201-3	2015	Thus, we performed a meta-analysis by pooling all currently available case-control studies to estimate the effect of TP53 codon 72 Arg/Pro polymorphism on the development of lung cancer in the Chinese population.	Arginine	131-134	tumor protein p53	Homo sapiens	117-121
25609251-3	2015	A His(nuc) to Ala mutant protein is reportedly inactive, whereas the autosomal recessive neurodegenerative disease SCAN1 has been attributed to the enhanced stability of the Tdp1-DNA intermediate induced by mutation of His(gab) to Arg.	Arginine	231-234	tyrosyl-DNA phosphodiesterase 1	Saccharomyces cerevisiae S288C	174-178
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	140-143	guanylate cyclase activator 1A	Homo sapiens	9-14
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	149-152	guanylate cyclase activator 1A	Homo sapiens	9-14
25636591-0	2015	Improvement of the physical performance is associated with activation of NO/PGC-1alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine.	Arginine	225-235	PPARG coactivator 1 alpha	Rattus norvegicus	76-86
25636591-10	2015	KEY FINDINGS: 8-week l-arginine supplementation associated with physical training was effective in promoting greater tolerance to exercise that was accompanied by up-regulation of the protein expressions of mtTFA, PGC-1alpha, ATP synthase subunit c, COXIV, Cu/Zn-SOD and Mn-SOD.	Arginine	21-31	PPARG coactivator 1 alpha	Rattus norvegicus	214-224
25636591-10	2015	KEY FINDINGS: 8-week l-arginine supplementation associated with physical training was effective in promoting greater tolerance to exercise that was accompanied by up-regulation of the protein expressions of mtTFA, PGC-1alpha, ATP synthase subunit c, COXIV, Cu/Zn-SOD and Mn-SOD.	Arginine	21-31	superoxide dismutase 1	Rattus norvegicus	257-266
25549551-5	2015	Docking study showed that the methoxy moeities of 6a inserted deep inside the 2 -pocket of the COX-2 active site, where the O-atoms of such groups underwent an H-bonding interaction with His(90) (3.02 A), Arg(513) (1.94, 2.83 A), and Gln(192) (3.25 A).	Arginine	205-208	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
25617479-7	2015	l-Arginine and soy enriched diet normalized serum PTH level and increased serum osteocalcin level; bone osteocalcin, osteoprotegerin and runt-related transcription factor2 mRNA levels compared to diabetic rats.	Arginine	0-10	parathyroid hormone	Rattus norvegicus	50-53
25890272-11	2015	The  adiA,  speC,  speF,  argR,  argA mutant with high gene copy number of argA214 and argO produced 11.64 g/L of arginine in batch fermentation, thereby demonstrating the potential of E. coli as an industrial producer of arginine.	Arginine	114-122	arginine repressor	Escherichia coli	26-30
25890272-11	2015	The  adiA,  speC,  speF,  argR,  argA mutant with high gene copy number of argA214 and argO produced 11.64 g/L of arginine in batch fermentation, thereby demonstrating the potential of E. coli as an industrial producer of arginine.	Arginine	222-230	arginine repressor	Escherichia coli	26-30
25617479-7	2015	l-Arginine and soy enriched diet normalized serum PTH level and increased serum osteocalcin level; bone osteocalcin, osteoprotegerin and runt-related transcription factor2 mRNA levels compared to diabetic rats.	Arginine	0-10	bone gamma-carboxyglutamate protein	Rattus norvegicus	80-91
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	46-54	splicing factor 3b subunit 2	Homo sapiens	13-19
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	46-54	protein arginine methyltransferase 9	Homo sapiens	37-42
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	99-107	splicing factor 3b subunit 2	Homo sapiens	13-19
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	99-107	protein arginine methyltransferase 9	Homo sapiens	37-42
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	99-107	splicing factor 3b subunit 2	Homo sapiens	13-19
25737013-3	2015	We show that SAP145 is methylated by PRMT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethylated arginine (SDMA).	Arginine	99-107	protein arginine methyltransferase 9	Homo sapiens	37-42
25737013-5	2015	Methylation of SAP145 on Arg 508 generates a binding site for the Tudor domain of the Survival of Motor Neuron (SMN) protein, and RNA-seq analysis reveals gross splicing changes when PRMT9 levels are attenuated.	Arginine	25-28	splicing factor 3b subunit 2	Homo sapiens	15-21
26005978-9	2015	Indians compared to control population presented: - TP53 super representation of Arg/Arg haplotype, 74.5% versus 42.5%, p&lt;0.0001.	Arginine	81-84	tumor protein p53	Homo sapiens	52-56
25893041-1	2015	The protein arginine methyltransferases PRMT7 and PRMT5, respectively, monomethylate and symmetrically dimethylate arginine side-chains of proteins involved in diverse cellular mechanisms, including chromatin-mediated control of gene transcription, splicing, and the RAS to ERK transduction cascade.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	50-55
25893041-1	2015	The protein arginine methyltransferases PRMT7 and PRMT5, respectively, monomethylate and symmetrically dimethylate arginine side-chains of proteins involved in diverse cellular mechanisms, including chromatin-mediated control of gene transcription, splicing, and the RAS to ERK transduction cascade.	Arginine	12-20	mitogen-activated protein kinase 1	Homo sapiens	274-277
25653279-10	2015	Collectively, our results indicate that arginine is essential for oTr1 cell proliferation and IFNT production via the NO/polyamine-TSC2-MTOR signaling pathways, particularly the pathway involving polyamine biosynthesis.	Arginine	40-48	mechanistic target of rapamycin kinase	Homo sapiens	136-140
25226867-7	2015	TP53 sequence analysis of the index patient revealed the germline mutation c.1025G &gt; C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53.	Arginine	156-164	tumor protein p53	Homo sapiens	0-4
25226867-7	2015	TP53 sequence analysis of the index patient revealed the germline mutation c.1025G &gt; C in a heterozygous state, resulting in an amino acid exchange from arginine to proline (p.Arg342Pro) in the tetramerization domain of p53.	Arginine	156-164	tumor protein p53	Homo sapiens	223-226
25653279-2	2015	Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways.	Arginine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	129-133
25582697-5	2015	Molecular analysis of lymphomas revealed that arginine methylation of p53 selectively suppresses expression of crucial proapoptotic and antiproliferative target genes, thereby sustaining tumor cell self-renewal and proliferation and bypassing the need for the acquisition of inactivating p53 mutations.	Arginine	46-54	tumor protein p53	Homo sapiens	70-73
25582697-5	2015	Molecular analysis of lymphomas revealed that arginine methylation of p53 selectively suppresses expression of crucial proapoptotic and antiproliferative target genes, thereby sustaining tumor cell self-renewal and proliferation and bypassing the need for the acquisition of inactivating p53 mutations.	Arginine	46-54	tumor protein p53	Homo sapiens	288-291
26005978-9	2015	Indians compared to control population presented: - TP53 super representation of Arg/Arg haplotype, 74.5% versus 42.5%, p&lt;0.0001.	Arginine	85-88	tumor protein p53	Homo sapiens	52-56
26090102-13	2015	Outcomes observed with TS1.6 and TS3.2 mice, respectively, confirm the hypothesis and reveal l-Arg as part of the mechanism.	Arginine	93-98	Trichinella spiralis resistance 3	Mus musculus	33-36
25573092-0	2015	Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia.	Arginine	17-27	insulin	Homo sapiens	0-7
25605962-0	2015	Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.	Arginine	0-8	splicing factor proline and glutamine rich	Homo sapiens	43-86
25605962-0	2015	Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.	Arginine	0-8	splicing factor proline and glutamine rich	Homo sapiens	88-92
25605962-0	2015	Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA.	Arginine	0-8	splicing factor proline and glutamine rich	Homo sapiens	93-96
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	49-57	splicing factor proline and glutamine rich	Homo sapiens	73-77
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	49-57	splicing factor proline and glutamine rich	Homo sapiens	78-81
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	49-57	splicing factor proline and glutamine rich	Homo sapiens	167-171
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	49-57	splicing factor proline and glutamine rich	Homo sapiens	172-175
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	129-138	splicing factor proline and glutamine rich	Homo sapiens	73-77
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	129-138	splicing factor proline and glutamine rich	Homo sapiens	78-81
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	129-138	splicing factor proline and glutamine rich	Homo sapiens	167-171
25605962-4	2015	In addition, we have identified several sites of arginine methylation in SFPQ/PSF using mass spectrometry and found that several arginines in the N-terminal domain of SFPQ/PSF are asymmetrically dimethylated.	Arginine	129-138	splicing factor proline and glutamine rich	Homo sapiens	172-175
25605962-6	2015	Arginine methylation and citrullination of SFPQ/PSF does not affect complex formation with NONO.	Arginine	0-8	splicing factor proline and glutamine rich	Homo sapiens	48-51
25561730-4	2015	Here, using chimeric and point-mutated GLP1R, we determined that the evolutionarily conserved amino acid residue Arg(380) flanked by hydrophobic Leu(379) and Phe(381) in extracellular loop 3 (ECL3) may have an interaction with Asp(9) and Gly(4) of the GLP-1 peptide.	Arginine	113-116	glucagon	Homo sapiens	252-257
25749850-3	2015	We developed a novel arginine-formulated fibrinogen from cryoprecipitates of porcine plasma.	Arginine	21-29	fibrinogen beta chain	Homo sapiens	41-51
25502809-10	2015	mRNA expression analysis indicated a shift in the arginine metabolism from NO formation to polyamine metabolism starting within 2 hours (h) of reperfusion and translated into protein expression within 24 h. Inhibition of the TNF-alpha pathway and captopril attenuated these delayed effects on post-ischaemic recovery.	Arginine	50-58	tumor necrosis factor	Rattus norvegicus	225-234
25527324-6	2015	It was shown that modification of the net charge of insulin induced by changes in the pH level of the incubation medium results in dramatic changes in the interaction of the protein with Arg.	Arginine	187-190	insulin	Homo sapiens	52-59
25706374-5	2015	For example, arginine, which is often found in the CDR-H3 of dsDNA binding autoantibodies, is under-represented in the commonly used DH RFs rearranged by deletion, but is a frequent component of rarely used inverted RF1 (iRF1), which is rearranged by inversion.	Arginine	13-21	retroperitoneal fat pad weight 1	Mus musculus	216-219
25444745-2	2015	Nitric oxide (NO) is produced from l-arginine in a reaction catalyzed by three distinct isoforms of NO synthase (NOS).	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	100-111
25527324-7	2015	We have revealed the dual effects of Arg, highly dependent on the pH level of the solution - suppression or acceleration of the aggregation of insulin at pH 7.0 or 8.0, respectively.	Arginine	37-40	insulin	Homo sapiens	143-150
25178386-1	2015	Variant-specific zinc transporter 8 autoantibodies (ZnT8A) against either arginine (R) or tryptophan (W) at amino acid (aa) position 325 of the zinc transporter 8 (ZnT8) has been identified in type 1 diabetes (T1D) patients.	Arginine	74-82	solute carrier family 30 member 8	Homo sapiens	17-35
25550342-1	2015	I. cooperative effects of arginine and secreted phosphoprotein 1 on proliferation of ovine trophectoderm cells via activation of the PDK1-Akt/PKB-TSC2-MTORC1 signaling cascade.	Arginine	26-34	AKT serine/threonine kinase 1	Homo sapiens	138-141
25550342-1	2015	I. cooperative effects of arginine and secreted phosphoprotein 1 on proliferation of ovine trophectoderm cells via activation of the PDK1-Akt/PKB-TSC2-MTORC1 signaling cascade.	Arginine	26-34	AKT serine/threonine kinase 1	Homo sapiens	142-145
25178386-1	2015	Variant-specific zinc transporter 8 autoantibodies (ZnT8A) against either arginine (R) or tryptophan (W) at amino acid (aa) position 325 of the zinc transporter 8 (ZnT8) has been identified in type 1 diabetes (T1D) patients.	Arginine	74-82	solute carrier family 30 member 8	Homo sapiens	144-162
25178386-1	2015	Variant-specific zinc transporter 8 autoantibodies (ZnT8A) against either arginine (R) or tryptophan (W) at amino acid (aa) position 325 of the zinc transporter 8 (ZnT8) has been identified in type 1 diabetes (T1D) patients.	Arginine	74-82	solute carrier family 30 member 8	Homo sapiens	52-56
25480793-9	2015	We show that the presence of an arginine rather than serine 512 provoked transporter misfolding, enhanced association to the ER-chaperone calnexin, altered association with the coat-protein complex II component Sec24D, and thereby impeded ER exit.	Arginine	32-40	SEC24 homolog D, COPII coat complex component	Homo sapiens	211-217
25521062-6	2015	Native NMU was found to be rapidly cleaved at the C-terminus between Arg(24) and Asn(25) , followed by cleavage between Arg(16) and Gly(17) .	Arginine	69-72	neuromedin U	Homo sapiens	7-10
25521062-6	2015	Native NMU was found to be rapidly cleaved at the C-terminus between Arg(24) and Asn(25) , followed by cleavage between Arg(16) and Gly(17) .	Arginine	120-123	neuromedin U	Homo sapiens	7-10
25560770-8	2015	The increased activation of intraplatelet arginase and platelet aggregability, in addition to an overexpression of PDE5 and oxidative stress may contribute to alterations in L-arginine-NO-cGMP pathway and in platelet function, and consequently to the increased thrombotic risk in MD.	Arginine	174-184	phosphodiesterase 5A	Homo sapiens	115-119
25447237-3	2015	It has been shown in cell culture that the nuclear import of FUS is mediated by transportin, which binds the PY-NLS and the last arginine/glycine/glycine-rich (RGG) domain of FUS.	Arginine	129-137	FUS RNA binding protein	Homo sapiens	61-64
25447237-3	2015	It has been shown in cell culture that the nuclear import of FUS is mediated by transportin, which binds the PY-NLS and the last arginine/glycine/glycine-rich (RGG) domain of FUS.	Arginine	129-137	FUS RNA binding protein	Homo sapiens	175-178
25480336-8	2015	Downregulation of c-Abl expression with siRNA attenuates LPS-induced VCAM-1 expression, whereas specific reduction of Arg reduces VE-cadherin expression in 18% CS-challenged ECs to mimic the imatinib effects.	Arginine	118-121	cadherin 5	Mus musculus	130-141
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Arginine	68-76	tumor protein p53	Homo sapiens	39-43
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Arginine	68-76	DEAD-box helicase 17	Homo sapiens	103-106
25256710-2	2015	Several genetic polymorphisms exist in TP53, including a proline to arginine variant at amino acid 72 (P72 and R72, respectively); this polymorphism alters p53 function.	Arginine	68-76	tumor protein p53	Homo sapiens	156-159
25529432-4	2015	The result showed that arginine preferentially bond to the aromatic amino acids of proteins mainly through hydrogen bonds and Van der Waals" forces, while the binding constant K of arginine with BSA and OVA at 298K was 41.92 and 5.77L/mol, respectively.	Arginine	23-31	albumin	Homo sapiens	195-198
25529432-4	2015	The result showed that arginine preferentially bond to the aromatic amino acids of proteins mainly through hydrogen bonds and Van der Waals" forces, while the binding constant K of arginine with BSA and OVA at 298K was 41.92 and 5.77L/mol, respectively.	Arginine	181-189	albumin	Homo sapiens	195-198
25529432-6	2015	We also found the attenuated electrostatic repulsion among BSA and OVA molecules after adding arginine.	Arginine	94-102	albumin	Homo sapiens	59-62
25529432-7	2015	These findings provided strong evidence that arginine possessed negative effects on tertiary conformational and colloidal stability of BSA and OVA during the preferential binding process.	Arginine	45-53	albumin	Homo sapiens	135-138
25729975-8	2015	In all patients, DNA sequencing of the CRYAA gene revealed a novel 3-bp deletion mutation in exon 3 (c.246_248delCGC), which led to deletion of codon 117 encoding arginine (p.117delR) in the peptide chain.	Arginine	163-171	crystallin alpha A	Homo sapiens	39-44
25425006-4	2015	NO is synthesized endogenously by the conversion of l-arginine into citrulline through nitric oxide synthase (NOS).	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	87-108
25642384-2	2015	Human protamine-1 (hPRM1) has been developed as a magnetic resonance imaging (MRI) chemical exchange saturation transfer (CEST) reporter gene, based on a sequence that is approximately 50% arginine, which has a side chain with rapidly exchanging protons.	Arginine	189-197	protamine 1	Homo sapiens	6-17
25642384-2	2015	Human protamine-1 (hPRM1) has been developed as a magnetic resonance imaging (MRI) chemical exchange saturation transfer (CEST) reporter gene, based on a sequence that is approximately 50% arginine, which has a side chain with rapidly exchanging protons.	Arginine	189-197	protamine 1	Homo sapiens	19-24
25425006-6	2015	O-ASCs and cancer cell cocultures revealed that cancer cells use O-ASC-secreted arginine and in turn secrete citrulline in the microenvironment.	Arginine	80-88	PYD and CARD domain containing	Homo sapiens	2-5
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Arginine	140-143	BW4	Homo sapiens	159-162
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Arginine	248-251	BW4	Homo sapiens	159-162
25480565-8	2015	Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding.	Arginine	81-84	BW4	Homo sapiens	37-40
25635535-4	2015	Silencing Arg-II or p38alpha in senescent cells recouples eNOS and inhibits IL-6 and IL-8 secretion.	Arginine	10-13	interleukin 6	Mus musculus	76-80
25585209-3	2015	We demonstrated that PRMT5-mediated histone arginine methylation is required to elicit ZNF224 transcriptional repression.	Arginine	44-52	protein arginine methyltransferase 5	Homo sapiens	21-26
25585209-5	2015	Also, we present evidence that the methylation of KAP1 arginine residues regulate the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification could actively contribute to the regulation of ZNF224-mediated repression.	Arginine	55-63	tripartite motif containing 28	Homo sapiens	50-54
25585209-5	2015	Also, we present evidence that the methylation of KAP1 arginine residues regulate the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification could actively contribute to the regulation of ZNF224-mediated repression.	Arginine	55-63	tripartite motif containing 28	Homo sapiens	86-90
25585209-5	2015	Also, we present evidence that the methylation of KAP1 arginine residues regulate the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification could actively contribute to the regulation of ZNF224-mediated repression.	Arginine	55-63	tripartite motif containing 28	Homo sapiens	86-90
25635535-6	2015	Moreover, p38 activation and expression of IL-6 and KC (the murine IL-8 homologue) are increased in the heart and/or aortas of wild type (WT) old mice, which is abolished in mice with Arg-II gene deficiency (Arg-II-/-).	Arginine	184-187	interleukin 6	Mus musculus	43-54
25747984-3	2015	The purpose of this study was to clarify the molecular mechanism(s) of uptake of L-Arg in retinal pericytes using a conditionally immortalized rat retinal pericyte cell line (TR-rPCT1 cells) which expresses the mRNAs of endothelial NO synthase and inducible NO synthase.	Arginine	81-86	nitric oxide synthase 2	Rattus norvegicus	248-269
25921167-1	2015	OBJECTIVE: To assess associations between codon 72 polymorphisms (Pro or B and Arg or b alleles) of the TP53 gene and lung cancer risk among Bangladeshis.	Arginine	79-82	tumor protein p53	Homo sapiens	104-108
24794573-0	2015	Structure of the Na,K-ATPase regulatory protein FXYD2b in micelles: implications for membrane-water interfacial arginines.	Arginine	112-121	FXYD domain containing ion transport regulator 2	Homo sapiens	48-53
26320432-1	2015	BACKGROUND: Earlier studies on the association between p53 codon 72 Arg&gt;Pro polymorphism and cancer risk were inconclusive and conflicting for the Saudi population.	Arginine	68-71	tumor protein p53	Homo sapiens	55-58
26320432-9	2015	CONCLUSIONS: The current meta-analysis suggests that the codon 72 Arg&gt;Pro polymorphism of the p53 gene might not contribute to cancer susceptibility in Saudi population.	Arginine	66-69	tumor protein p53	Homo sapiens	97-100
26662654-5	2015	This mutation results in arginine to glutamine substitution at the protein level, while phenotypically this condition presents with a loss of body fat, insulin resistance, dyslipidaemia, and other features mimicking PCOS.	Arginine	25-33	insulin	Homo sapiens	152-159
25324168-2	2015	In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2.	Arginine	111-119	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	142-146
25927346-0	2015	PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington"s disease (HD).	Arginine	26-34	protein arginine methyltransferase 5	Homo sapiens	0-5
25927346-2	2015	Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimethylation of arginine (sDMA) of key cellular proteins, including histones, and spliceosomal Sm proteins.	Arginine	63-71	protein arginine methyltransferase 5	Homo sapiens	93-98
25927346-9	2015	These studies revealed a potential new mechanism for disruption of gene expression and RNA processing in HD, involving a loss of normal function of Htt in facilitation of PRMT5, supporting the idea that epigenetic regulation of gene transcription may be involved in HD and highlighting symmetric dimethylation of arginine as potential new therapeutic target.	Arginine	313-321	protein arginine methyltransferase 5	Homo sapiens	171-176
26642706-9	2015	RESULTS: Two ZnT8 antigens (arginine and tryptophan ZnT8 at position 325) were successfully produced.	Arginine	28-36	solute carrier family 30 member 8	Homo sapiens	13-17
25092678-4	2015	Mice with deletion of PTEN, a negative regulator of this pathway, in alpha-cells show reduced circulating glucagon levels and attenuated l-arginine-stimulated glucagon secretion both in vivo and in vitro.	Arginine	137-147	phosphatase and tensin homolog	Mus musculus	22-26
26424307-5	2015	Genetic testing revealed a novel missense mutation at codon 561 in exon 10, resulting in an amino acid substitution from methionine to arginine (M561R) in the MEN1 gene.	Arginine	135-143	menin 1	Homo sapiens	159-163
25323013-13	2015	CONCLUSION: In critical illnesses, insulin therapy under overfed conditions may impair the physiological supply of AAs and conditionally essential AA starvation, such as glutamine and arginine, and may have an adverse impact on the prognosis of patients.	Arginine	184-192	insulin	Homo sapiens	35-42
25039245-8	2015	This was related to the inability of C3-deficient DC to up-regulate the arginine-consuming enzyme, inducible nitric oxide synthase (Nos-2), in the presence of antigen-specific Treg cells and peptide, leading to reduced Treg cell generation.	Arginine	72-80	nitric oxide synthase 2, inducible	Mus musculus	99-130
26260685-3	2015	Interestingly, in cell-based studies CREBBP activity is modulated by post-translational modifications such as methylation on arginine residues which is catalyzed by coactivator-associated arginine methyltransferase 1 (CARM1).	Arginine	125-133	coactivator-associated arginine methyltransferase 1	Danio rerio	165-216
26260685-3	2015	Interestingly, in cell-based studies CREBBP activity is modulated by post-translational modifications such as methylation on arginine residues which is catalyzed by coactivator-associated arginine methyltransferase 1 (CARM1).	Arginine	125-133	coactivator-associated arginine methyltransferase 1	Danio rerio	218-223
25692069-14	2015	Our results suggest that arginases can compete with NOS2 for L-arginine during Behcet disease.	Arginine	61-71	nitric oxide synthase 2	Homo sapiens	52-56
26598853-5	2015	Individual amino acids such as lysine and arginine have been found to be factors linked to growth hormone release in young children via the somatotropic axis and high intakes are inversely associated with fat mass index in pre-pubertal lean girls.	Arginine	42-50	growth hormone 1	Homo sapiens	91-105
26576438-2	2015	Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand beta1 and the beginning of strand beta2, respectively.	Arginine	51-60	islet amyloid polypeptide	Mus musculus	103-109
25614305-3	2015	A correlation between LPI and growth hormone deficiency (GHD) has also been postulated because of the known interaction between the AA arginine, ornithine, and lysine and growth hormone (GH) secretion.	Arginine	135-143	growth hormone 1	Homo sapiens	30-44
25463020-7	2015	Mutational analysis of Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel confirmed their role in binding and inhibition of COX-2 by IBP.	Arginine	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	139-144
25734763-3	2015	PON1 activity shows great variability in the population as a result of a polymorphism in the coding sequence that is expressed as a Glu(Q)/Arg(R) substitution at position 192 of the amino acid sequence.	Arginine	139-142	paraoxonase 1	Homo sapiens	0-4
25814382-0	2015	Arginine Functionally Improves Clinically Relevant Human Galactose-1-Phosphate Uridylyltransferase (GALT) Variants Expressed in a Prokaryotic Model.	Arginine	0-8	galactose-1-phosphate uridylyltransferase	Homo sapiens	57-98
25814382-0	2015	Arginine Functionally Improves Clinically Relevant Human Galactose-1-Phosphate Uridylyltransferase (GALT) Variants Expressed in a Prokaryotic Model.	Arginine	0-8	galactose-1-phosphate uridylyltransferase	Homo sapiens	100-104
25814382-4	2015	Arginine is a known stabilizer of aggregation-prone proteins, having already shown a beneficial effect in other inherited metabolic disorders.Herein we developed a prokaryotic model of galactose sensitivity that allows evaluating in a cellular context the mutations" impact on GALT function, as well as the potential effect of arginine in functionally rescuing clinically relevant variants.This study revealed that some hGALT variants, previously described to exhibit no detectable activity in vitro, actually present residual activity when determined in vivo.	Arginine	0-8	galactose-1-phosphate uridylyltransferase	Homo sapiens	277-281
25814382-4	2015	Arginine is a known stabilizer of aggregation-prone proteins, having already shown a beneficial effect in other inherited metabolic disorders.Herein we developed a prokaryotic model of galactose sensitivity that allows evaluating in a cellular context the mutations" impact on GALT function, as well as the potential effect of arginine in functionally rescuing clinically relevant variants.This study revealed that some hGALT variants, previously described to exhibit no detectable activity in vitro, actually present residual activity when determined in vivo.	Arginine	0-8	galactose-1-phosphate uridylyltransferase	Homo sapiens	420-425
25336270-0	2015	L-arginine stimulates CAT-1-mediated arginine uptake and regulation of inducible nitric oxide synthase for the growth of chick intestinal epithelial cells.	Arginine	0-10	solute carrier family 7 member 1	Gallus gallus	22-27
26788019-5	2015	However, at codon 88, one of the interaction sites between IL17A and its receptor IL17RA, there is an Arg&gt;Pro mutation that only occurs in European rabbit and European brown hare.	Arginine	102-105	interleukin-17A	Oryctolagus cuniculus	59-64
26788019-5	2015	However, at codon 88, one of the interaction sites between IL17A and its receptor IL17RA, there is an Arg&gt;Pro mutation that only occurs in European rabbit and European brown hare.	Arginine	102-105	interleukin-17 receptor A	Oryctolagus cuniculus	82-88
25502079-3	2015	A common polymorphism of the p53 codon 72 in exon 4 with two alleles encoding arginine or proline is known at this locus.	Arginine	78-86	tumor protein p53	Homo sapiens	29-32
25336270-0	2015	L-arginine stimulates CAT-1-mediated arginine uptake and regulation of inducible nitric oxide synthase for the growth of chick intestinal epithelial cells.	Arginine	2-10	solute carrier family 7 member 1	Gallus gallus	22-27
25336270-2	2015	The present study was conducted to investigate the extracellular concentrations of L-Arg regulating the CAT-1, CAT-4 and inducible NOS (iNOS) in chick intestinal epithelial cells.	Arginine	83-88	solute carrier family 7 member 1	Gallus gallus	104-109
25336270-2	2015	The present study was conducted to investigate the extracellular concentrations of L-Arg regulating the CAT-1, CAT-4 and inducible NOS (iNOS) in chick intestinal epithelial cells.	Arginine	83-88	nitric oxide synthase 2	Gallus gallus	121-134
25336270-2	2015	The present study was conducted to investigate the extracellular concentrations of L-Arg regulating the CAT-1, CAT-4 and inducible NOS (iNOS) in chick intestinal epithelial cells.	Arginine	83-88	nitric oxide synthase 2	Gallus gallus	136-140
25336270-7	2015	Increasing extracellular concentrations of L-Arg from 10 to 400 muM dose dependently increased the levels of CAT-1 mRNA and protein, while no effect on CAT-4 mRNA abundance was found.	Arginine	43-48	solute carrier family 7 member 1	Gallus gallus	109-114
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	53-58	nitric oxide synthase 2	Gallus gallus	89-93
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	53-58	nitric oxide synthase 2	Gallus gallus	136-140
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	160-165	nitric oxide synthase 2	Gallus gallus	89-93
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	160-165	nitric oxide synthase 2	Gallus gallus	136-140
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	160-165	nitric oxide synthase 2	Gallus gallus	89-93
25336270-8	2015	Furthermore, supplementation of 100, 200, or 400 muM L-Arg upregulated the expression of iNOS mRNA, and the relative protein levels for iNOS in 200 and 400 muM L-Arg groups were higher than those in 10 and 100 muM L-Arg groups.	Arginine	160-165	nitric oxide synthase 2	Gallus gallus	136-140
25336270-9	2015	Collectively, we conclude that the CAT-1 isoform plays a role in L-Arg uptake, and L-Arg-mediated elevation of NO via iNOS promotes the growth of chick intestinal epithelial cells.	Arginine	65-70	solute carrier family 7 member 1	Gallus gallus	35-40
25336270-9	2015	Collectively, we conclude that the CAT-1 isoform plays a role in L-Arg uptake, and L-Arg-mediated elevation of NO via iNOS promotes the growth of chick intestinal epithelial cells.	Arginine	83-88	nitric oxide synthase 2	Gallus gallus	118-122
25734013-11	2015	Arginine treated patients had significantly increased BMI at the end of the first and second months of treatment (P = 0.032 and P = 0.04) and a reduced CRP at the end of the first month of treatment (P = 0.03) versus placebo group.	Arginine	0-8	C-reactive protein	Homo sapiens	152-155
26368055-8	2015	However, the levels of 7 amino acids showed significantly different alteration between atg5 and WT in the dark: 6 amino acids, particularly arginine and alanine, were much more deficient in the atg5 mutants, irrespective of the early degradation of Rubisco protein.	Arginine	140-148	Atg5p	Saccharomyces cerevisiae S288C	194-198
25452338-5	2015	One linker position, glycine in NagC and arginine in Mlc, corresponds to the major specificity determinant for the two proteins.	Arginine	41-49	modulator of VRAC current 1	Homo sapiens	53-56
25452338-6	2015	In certain contexts it is possible to switch repression from Mlc-style to NagC-style, by interchanging this glycine and arginine.	Arginine	120-128	modulator of VRAC current 1	Homo sapiens	61-64
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Arginine	66-69	proopiomelanocortin	Homo sapiens	3-12
25543846-1	2014	BACKGROUND: Trypsinogen is the inactive precursor of trypsin, a serine protease that cleaves proteins and peptides after arginine and lysine residues.	Arginine	121-129	trypsinogen	Cavia porcellus	12-23
25382150-9	2015	All animals exhibited insulin, C-peptide, and glucagon responses to both glucose and arginine challenge; however, significant interindividual variation was observed.	Arginine	85-93	insulin	Homo sapiens	22-29
25541963-8	2014	Maximal insulin response following arginine challenge was also significantly attenuated (iAUC HME: 7.14 [4.22-10.5] vs. controls 10.2 [7.91-12.70] nmol l-1 min-1 p&lt;0.05), indicative of an impaired beta-cell reserve.	Arginine	35-43	CD59 molecule (CD59 blood group)	Homo sapiens	156-161
25526208-6	2014	The p53 codon 72 Pro/Pro genotype was associated with a longer median PFS time of 30.3 months compared with 18.2 months for patients with Arg/Arg variants.	Arginine	138-141	tumor protein p53	Homo sapiens	4-7
25485739-5	2014	Our studies confirm that arginine 3 is the only site of methylation in both histone H4 and H4 tail peptide analogues and that sites distal to the site of methylation promote the efficient symmetric dimethylation of PRMT5 substrates by increasing the affinity of the monomethylated substrate for the enzyme.	Arginine	25-33	protein arginine methyltransferase 5	Homo sapiens	215-220
25526208-6	2014	The p53 codon 72 Pro/Pro genotype was associated with a longer median PFS time of 30.3 months compared with 18.2 months for patients with Arg/Arg variants.	Arginine	142-145	tumor protein p53	Homo sapiens	4-7
25381251-4	2014	The mutant ETBR (designated "5KR mutant") in which 5 lysine residues in the C-tail were substituted to arginine was not ubiquitinated, and its rates of internalization and degradation after ET-1 stimulation became slower, being comparable with those of ETAR.	Arginine	103-111	endothelin receptor type B	Homo sapiens	11-15
25381251-7	2014	A series of ETBR mutants (designated "4KR mutant"), in which either one of 5 arginine residues of the 5KR mutant was reverted to lysine, were normally ubiquitinated, internalized, and degraded, with ERK phosphorylation being normalized.	Arginine	77-85	endothelin receptor type B	Homo sapiens	12-16
25526208-7	2014	Moreover, the p53 codon 72 Pro/ Pro genotype was associated with a longer median OS time of 31.6 months compared with 25.8 months for those with Arg/Arg variants; the P value was marginally significant.	Arginine	145-148	tumor protein p53	Homo sapiens	14-17
25526208-7	2014	Moreover, the p53 codon 72 Pro/ Pro genotype was associated with a longer median OS time of 31.6 months compared with 25.8 months for those with Arg/Arg variants; the P value was marginally significant.	Arginine	149-152	tumor protein p53	Homo sapiens	14-17
25392530-2	2014	Airway epithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to arginines 14 and 24 of HNP-1.	Arginine	32-40	ADP-ribosyltransferase 1	Homo sapiens	50-80
25392530-2	2014	Airway epithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to arginines 14 and 24 of HNP-1.	Arginine	139-148	ADP-ribosyltransferase 1	Homo sapiens	50-80
25392530-7	2014	Thus, arginines 14 and 24, which can be ADP ribosylated by ART1, are critical to the regulation of the cytotoxic and antibacterial effects of HNP-1.	Arginine	6-15	ADP-ribosyltransferase 1	Homo sapiens	59-63
25399921-3	2014	Rodent Abeta (rAbeta) differs from human Abeta (hAbeta) only in the three substitutions of Arg to Gly, Tyr to Phe, and His to Arg at positions 5, 10, and 13, respectively.	Arginine	91-94	amyloid beta precursor protein	Homo sapiens	7-12
25399921-3	2014	Rodent Abeta (rAbeta) differs from human Abeta (hAbeta) only in the three substitutions of Arg to Gly, Tyr to Phe, and His to Arg at positions 5, 10, and 13, respectively.	Arginine	91-94	amyloid beta precursor protein	Homo sapiens	48-54
25458834-6	2014	There is a common interaction mode between consecutive acidic residues on the ligands and the same arginine residues on CLEC-2.	Arginine	99-107	C-type lectin domain family 1 member B	Homo sapiens	120-126
25103594-10	2014	This revealed the presence of a substitution Arg&gt;Cys in position 275 of the gamma-chain of the fibrinogen.	Arginine	45-48	fibrinogen beta chain	Homo sapiens	98-108
25810899-2	2014	We previously identified that TLS was associated with protein arginine methyltransferase 1 (PRMT1), and four arginine residues within TLS (R216, R218, R242 and R394) were consistently dimethylated.	Arginine	62-70	FUS RNA binding protein	Homo sapiens	30-33
25810899-4	2014	RESULTS: To understand the biological role of arginine methylation of RNA-binding protein, we prepared and characterized a mouse monoclonal antibody against asymmetric dimethylarginine of TLS.	Arginine	46-54	FUS RNA binding protein	Homo sapiens	188-191
25810899-7	2014	2B12 was also validated GST tagged TLS with PRMT1 by in vitro arginine methylation assays.	Arginine	62-70	FUS RNA binding protein	Homo sapiens	35-38
25096520-6	2014	Our results show that arginine: increased the ratio of phosphorylated to total mTOR (146 %), S6 (40 %) and 4EBP1 (69 %); increased protein synthesis (69 %) during the first hour of treatment; and increased myotube diameter by ~15 %.	Arginine	22-30	mechanistic target of rapamycin kinase	Homo sapiens	79-83
25096520-6	2014	Our results show that arginine: increased the ratio of phosphorylated to total mTOR (146 %), S6 (40 %) and 4EBP1 (69 %); increased protein synthesis (69 %) during the first hour of treatment; and increased myotube diameter by ~15 %.	Arginine	22-30	nuclear factor kappa B subunit 1	Homo sapiens	108-112
25501750-0	2014	A novel role for SIRT-1 in L-arginine protection against STZ induced myocardial fibrosis in rats.	Arginine	27-37	sirtuin 1	Rattus norvegicus	17-23
25027835-2	2014	The PON1 gene has single nucleotide polymorphisms (SNPs) including a codon 192 arginine (R) to glutamine (Q) and methionine (M) to leucine (L) at codon 55.	Arginine	79-87	paraoxonase 1	Homo sapiens	4-8
25501750-3	2014	Accordingly, this study aimed at delineating a role for SIRT-1 in mediating L-ARG protection against streptozotocin (STZ) induced myocardial fibrosis.	Arginine	76-81	sirtuin 1	Rattus norvegicus	56-62
25501750-6	2014	RESULTS: L-ARG increased myocardial SIRT-1 expression as well as its protein content.	Arginine	9-14	sirtuin 1	Rattus norvegicus	36-42
25501750-9	2014	Moreover, L-ARG increased MMP-2 expression in addition to its protein content while decreasing expression of PAI-1.	Arginine	10-15	serpin family E member 1	Rattus norvegicus	109-114
25501750-12	2014	CONCLUSION: Collectively, these findings associate a role for SIRT-1 in L-ARG defense against diabetic cardiac fibrosis via equilibrating the balance between profibrotic and antifibrotic mediators.	Arginine	72-77	sirtuin 1	Rattus norvegicus	62-68
25503125-2	2014	Exposure of these ASS-negative cells to the arginine degrading enzyme, arginine deiminase (ADI-PEG20), for 72 h results in significant increases in cleaved caspase-3.	Arginine	44-52	caspase 3	Homo sapiens	156-165
25253739-3	2014	As previously reported, an arginine in the pre-helix loop of GDF5 defines the high binding specificity to its type 1 receptor.	Arginine	27-35	growth differentiation factor 5	Homo sapiens	61-65
25253739-4	2014	Interestingly, bioactive mouse GDF9 and human BMP15 share the conserved arginine in the pre-helix loop, but their low-activity counterparts (mouse BMP15 and human GDF9) have a glycine or a proline instead.	Arginine	72-80	bone morphogenetic protein 15	Homo sapiens	46-51
25245031-8	2014	CONCLUSIONS: These genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2.	Arginine	119-129	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	75-80
25245031-8	2014	CONCLUSIONS: These genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2.	Arginine	119-129	mediator complex subunit 23	Homo sapiens	85-90
25245031-8	2014	CONCLUSIONS: These genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2.	Arginine	119-129	alanine--glyoxylate aminotransferase 2	Homo sapiens	214-219
24115240-1	2014	BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro).	Arginine	76-84	tumor protein p53	Homo sapiens	16-20
24115240-1	2014	BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro).	Arginine	86-89	tumor protein p53	Homo sapiens	16-20
25318354-2	2014	It differs from HLA-A*68:01:02 at five nucleotides, three intronic, nt 699 T-&gt;G (intron 2), nt 705 T-&gt;C (intron 2) and nt 2770 G-&gt;A (intron 7), and two located in exon 3, at positions 726 A-G (codon 94 Ile-&gt;Val) and 733 T-G (codon 97 Arg-&gt;Met), respectively.	Arginine	246-249	major histocompatibility complex, class I, A	Homo sapiens	16-21
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Arginine	136-146	nitric oxide synthase 2	Homo sapiens	0-31
26171365-4	2014	We describe here a novel heterozygous -T to -C transition at codon 202 (TGC CGC) of the GJB2 gene in a patient, 40-year-old Iranian woman, which replaces a cysteine with an arginine residue (C202R).	Arginine	173-181	gap junction protein beta 2	Homo sapiens	88-92
25531191-7	2014	Activity of e-NOS in sperm was evaluated in parallel by measuring the quantity of L-citulline produced from L-arginine.	Arginine	108-118	nitric oxide synthase 3	Homo sapiens	12-17
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Arginine	148-153	nitric oxide synthase 2	Homo sapiens	0-31
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Arginine	148-153	nitric oxide synthase 2	Homo sapiens	33-37
25187572-4	2014	O-GlcNAc modification occurs in close proximity to phosphorylated residues and novel sites of arginine methylation within regions known to regulate Runx2 transactivation.	Arginine	94-102	RUNX family transcription factor 2	Homo sapiens	148-153
25187573-13	2014	The more positively charged lysine and arginine residues in the N and C termini suggest that synovial lubricin exists as an amphoteric molecule.	Arginine	39-47	proteoglycan 4	Homo sapiens	102-110
25823239-3	2014	NO is generated through the conversion of L-arginine to L-citrulline by the action of nitric oxide synthase (NOS) and iNOS is highly expressed in asthmatic airways.	Arginine	42-52	nitric oxide synthase 2	Homo sapiens	86-107
25823239-3	2014	NO is generated through the conversion of L-arginine to L-citrulline by the action of nitric oxide synthase (NOS) and iNOS is highly expressed in asthmatic airways.	Arginine	42-52	nitric oxide synthase 2	Homo sapiens	118-122
25454139-8	2014	Furthermore, using low concentration of l-arginine combined with urea as common aggregation suppressor additives showed insignificant change in kinetics of refolding of lysozyme on SEC.	Arginine	40-50	lysozyme	Homo sapiens	169-177
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Arginine	77-85	B cell leukemia/lymphoma 2	Mus musculus	8-13
25429397-5	2014	Accordingly, more mucous cells are present in primary human airway cultures with p53(Arg) compared with p53(Pro).	Arginine	85-88	tumor protein p53	Homo sapiens	81-84
25653844-1	2014	Inducible nitric oxide synthase (iNOS) is a homodimeric heme enzyme that catalyzes the formation of nitric oxide (NO) from dioxygen and L-arginine (L-Arg) in a two-step process.	Arginine	136-146	nitric oxide synthase 2	Homo sapiens	33-37
25324545-4	2014	Here, we report that PPAD citrullination of a critical C-terminal arginine of the anaphylatoxin C5a disabled the protein function.	Arginine	66-74	complement C5a receptor 1	Homo sapiens	96-99
25422897-7	2014	In contrast, a high local density of arginines from lysozyme allows strong binding with Abeta peptide monomers, resulting in stable complexes.	Arginine	37-46	amyloid beta precursor protein	Homo sapiens	88-93
25427151-6	2014	The results of this study have pointed to a central role of the conserved His-Arg-Asp (HRD) motif in the catalytic loop and the Asp-Phe-Gly (DFG) motif as key mediators of structural stability and allosteric communications in the ErbB kinases.	Arginine	78-81	epidermal growth factor receptor	Homo sapiens	230-234
25423173-1	2014	The insulin gene mutation c.137G&gt;A (R46Q), which changes an arginine at the B22 position of the mature hormone to glutamine, causes the monogenic diabetes variant maturity-onset diabetes of the young (MODY).	Arginine	63-71	insulin	Homo sapiens	4-11
25324545-7	2014	Further, after treatment of C5 with outer membrane vesicles naturally shed by P. gingivalis, we observed generation of C5a totally citrullinated at the C-terminal Arg-74 residue (Arg74Cit).	Arginine	163-166	complement C5a receptor 1	Homo sapiens	119-122
25418316-1	2014	Relaxation of a hERG K(+) channel model during molecular-dynamics simulation in a hydrated POPC bilayer was accompanied by transitions of an arginine gating charge across a charge transfer center in two voltage sensor domains.	Arginine	141-149	ETS transcription factor ERG	Homo sapiens	16-20
25352667-7	2014	Because this invariant Arg is strictly required to stimulate Torsin ATPase activity but is dispensable for Torsin binding, we propose that LAP1 and LULL1 regulate Torsin ATPase activity through an active site complementation mechanism.	Arginine	23-26	torsin 1A interacting protein 1	Homo sapiens	139-143
26019598-7	2014	eNOS is a subgroup of this family of enzymes that catalyses the production of nitric oxide (NO) from L-arginine and oxygen, which leads to vascular relaxation by activating the guanylate cyclase.	Arginine	101-111	nitric oxide synthase 3	Homo sapiens	0-4
25429216-5	2014	Herein, we developed a novel PHD2 silencing system based on arginine-terminated generation 4 poly(amidoamine) (Arg-G4) nanoparticles.	Arginine	60-68	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-33
25429216-5	2014	Herein, we developed a novel PHD2 silencing system based on arginine-terminated generation 4 poly(amidoamine) (Arg-G4) nanoparticles.	Arginine	111-114	egl-9 family hypoxia inducible factor 1	Homo sapiens	29-33
25429216-9	2014	This work demonstrated that an Arg-G4 nanovector-based PHD2 silencing system could enhance the efficiency of MSC transplantation for infarcted myocardium repair.	Arginine	31-34	egl-9 family hypoxia inducible factor 1	Homo sapiens	55-59
25367122-6	2014	RESULTS: Mutation of arginine 74 induced only limited and local changes to the gal-7 fold.	Arginine	21-29	galectin 7	Homo sapiens	79-84
25205820-0	2014	Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Galpha(i2).	Arginine	32-42	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	85-94
25205820-9	2014	In contrast, the two- to threefold increase in insulin secretion evoked by L-arginine or L-ornithine (in the presence of 16 mM glucose) was significantly reduced in islets lacking Galpha(i2).	Arginine	75-85	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	180-189
25281873-1	2014	Protein arginine methyltransferase 5 (PRMT5) symmetrically methylates arginine residues of histones and non-histone protein substrates and regulates a variety of cellular processes through epigenetic control of target gene expression or post-translational modification of signaling molecules.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
25149208-1	2014	RNA helicase A (RHA), a DExD/H protein, contains a stretch of repeated arginine and glycine-glycine (RGG) residues and an oligonucleotide/oligosaccharide-binding fold (OB-fold) at the C-terminus.	Arginine	71-79	DExH-box helicase 9	Homo sapiens	0-14
25149208-1	2014	RNA helicase A (RHA), a DExD/H protein, contains a stretch of repeated arginine and glycine-glycine (RGG) residues and an oligonucleotide/oligosaccharide-binding fold (OB-fold) at the C-terminus.	Arginine	71-79	DExH-box helicase 9	Homo sapiens	16-19
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Arginine	185-188	albumin	Homo sapiens	63-66
25288495-0	2014	Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.	Arginine	19-22	MAS-related G-protein coupled receptor, member C	Rattus norvegicus	81-85
25301772-7	2014	Docking experiments revealed that fluconazole and DTP binds in HSA mainly by hydrophobic interaction with the possibility of hydrogen bonds formation between the drugs and the residues Arg 222, Lys 199 and Lys 195 in HSA.	Arginine	185-188	albumin	Homo sapiens	217-220
25347266-7	2014	As determined from the spleen after the FST: Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	53-56	interleukin 1 beta	Mus musculus	82-90
25347266-7	2014	As determined from the spleen after the FST: Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	106-109	interleukin 6	Mus musculus	135-139
25347266-9	2014	As determined from the serum after the TST: PE and Gly regulated the effects of TNF-alpha; Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	99-102	interleukin 1 beta	Mus musculus	128-136
25347266-9	2014	As determined from the serum after the TST: PE and Gly regulated the effects of TNF-alpha; Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	152-155	interleukin 6	Mus musculus	181-185
24766780-3	2014	The combined (1)H-NMR spectroscopic and molecular dynamics methods were used to investigate the conformational behavior of an Arg-Gly-Asp (RGD)-containing peptide, GRGDSPC, the cell-binding heptapeptide of extracellular matrix protein, fibronectin.	Arginine	126-129	fibronectin 1	Homo sapiens	236-247
25304217-3	2014	Lyophilized tPA, obtained as Actilyse 50 mg from Boehringer Ingelheim containing arginine was utilized.	Arginine	81-89	plasminogen activator, tissue type	Homo sapiens	12-15
25092686-3	2014	beta-Cell function was assessed by the C-peptide response to arginine stimulation.	Arginine	61-69	insulin	Homo sapiens	39-48
25092686-6	2014	RESULTS: Compared with the control subjects, T2DM subjects had threefold reduced C-peptide responses to arginine stimulation.	Arginine	104-112	insulin	Homo sapiens	81-90
25263501-10	2014	LPS/D-GalN-induced inflammation, as confirmed by the increased MPO activity, created an asymmetrical distribution of arginine and ADMA between the tissue and plasma.	Arginine	117-125	galanin and GMAP prepropeptide	Rattus norvegicus	6-10
25304217-13	2014	The 0.423 mug of arginine, which is associated with 0.01 mug tPA, was injected alone and had no effect.	Arginine	17-25	plasminogen activator, tissue type	Homo sapiens	61-64
25172508-4	2014	When a series of galectin-7 fragments containing beta-strand peptides were prepared to compare their amyloidogenesis, Ser(31)-Gln(67) and Arg(120)-Phe(136) were aggregated to form amyloid fibrils at pH 2.0.	Arginine	138-141	galectin 7	Homo sapiens	17-27
25252954-2	2014	The mice inherited abolished IgG serum titers in a recessive manner caused by a spontaneous G   A transition mutation in codon 112 of the aicda gene, leading to an arginine to histidine replacement (AID(R112H)).	Arginine	164-172	activation-induced cytidine deaminase	Mus musculus	199-202
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Arginine	22-25	parathyroid hormone	Homo sapiens	32-51
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Arginine	22-25	parathyroid hormone	Homo sapiens	53-56
25218037-0	2014	A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.	Arginine	22-25	parathyroid hormone 1 receptor	Homo sapiens	77-90
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Arginine	76-79	parathyroid hormone	Homo sapiens	0-3
25218037-2	2014	PTH"s interaction with the N-terminal domain of PTH1 is mediated in part by Arg-20 on the peptide which forms a number of interactions with the receptor: a charge-charge interaction with Asp-137; hydrogen bonds with the backbone of Asp-29 and Met-32; and hydrophobic interactions with Met-32 and Gln-37.	Arginine	76-79	parathyroid hormone	Homo sapiens	48-52
25218037-4	2014	The substitution of Arg-20 with norleucine resulted in a 50-fold reduction in potency at PTH1 and Asp-137-Glu while, in contrast, both Asp-137-Asn and Asp-137-Ala receptors were largely insensitive to this ligand modification.	Arginine	20-23	parathyroid hormone	Homo sapiens	89-93
25218037-7	2014	These data demonstrate that a negative charge at residue-137 is important for interacting with ligands containing a positive charge at residue-20, and that the Arg-20 interaction with Asp-137, observed in the crystal structure of the isolated N-terminal domain of PTH1, is likely to be present in the full length receptor where it provides an important affinity- and potency-generating interaction through a salt bridge.	Arginine	160-163	parathyroid hormone	Homo sapiens	264-268
26814446-4	2014	However, ELISA results showed that the Arg-Gly-Asp (RGD) activity of adsorbed Fn decreased with the increase of PHEMA thickness.	Arginine	39-42	fibronectin 1	Homo sapiens	78-80
25195797-5	2014	A reduction of arginine levels, accomplished using an arginine auxotrophic ARG4-deletion strain in the presence of limiting amounts of arginine or through CAR1 overexpression, did however not correlate with an increased ethylene production.	Arginine	15-23	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	75-79
25195797-6	2014	As expected, arginine was necessary for ethylene production as ethylene production in the ARG4-deletion strain ceased at the time when arginine was depleted.	Arginine	13-21	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	90-94
25195797-6	2014	As expected, arginine was necessary for ethylene production as ethylene production in the ARG4-deletion strain ceased at the time when arginine was depleted.	Arginine	135-143	argininosuccinate lyase ARG4	Saccharomyces cerevisiae S288C	90-94
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	170-173	tumor protein p53	Homo sapiens	55-59
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	170-173	tumor protein p53	Homo sapiens	165-169
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	170-173	tumor protein p53	Homo sapiens	165-169
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	174-177	tumor protein p53	Homo sapiens	55-59
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	174-177	tumor protein p53	Homo sapiens	165-169
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	174-177	tumor protein p53	Homo sapiens	165-169
25316267-5	2014	Analysis of combined MDM2/TP53 polymorphisms revealed that T/T-Pro/Arg genotype decreased EC risk, whereas G/G-Arg/Arg genotype increased it.	Arginine	67-70	tumor protein p53	Homo sapiens	26-30
25316267-6	2014	Association of these genetic polymorphisms with histological grading showed increased MDM2 G/G homozygote and TP53 Arg/Arg homozygote frequencies in grading 2 as well as allele G overrepresentation in G1 and G3 EC patients.	Arginine	115-118	tumor protein p53	Homo sapiens	110-114
25316267-6	2014	Association of these genetic polymorphisms with histological grading showed increased MDM2 G/G homozygote and TP53 Arg/Arg homozygote frequencies in grading 2 as well as allele G overrepresentation in G1 and G3 EC patients.	Arginine	119-122	tumor protein p53	Homo sapiens	110-114
25316267-7	2014	Finally, with clinical FIGO staging under evaluation, an increase in MDM2 G/G and TP53 Arg/Arg homozygote frequencies in staging I and TP53 Arg/Arg homozygote frequencies in staging II were observed.	Arginine	87-90	tumor protein p53	Homo sapiens	82-86
25316267-7	2014	Finally, with clinical FIGO staging under evaluation, an increase in MDM2 G/G and TP53 Arg/Arg homozygote frequencies in staging I and TP53 Arg/Arg homozygote frequencies in staging II were observed.	Arginine	91-94	tumor protein p53	Homo sapiens	82-86
25316267-7	2014	Finally, with clinical FIGO staging under evaluation, an increase in MDM2 G/G and TP53 Arg/Arg homozygote frequencies in staging I and TP53 Arg/Arg homozygote frequencies in staging II were observed.	Arginine	91-94	tumor protein p53	Homo sapiens	82-86
25316267-7	2014	Finally, with clinical FIGO staging under evaluation, an increase in MDM2 G/G and TP53 Arg/Arg homozygote frequencies in staging I and TP53 Arg/Arg homozygote frequencies in staging II were observed.	Arginine	91-94	tumor protein p53	Homo sapiens	82-86
25341359-5	2014	The putative NLS of c-Met is unique in that it relies on histidines, whose positive charge changes depending on pH, rather than the lysines or arginines, commonly found in classical bipartite NLSs, suggesting the possible "pH-dependency" of this NLS.	Arginine	143-152	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
25159323-3	2014	This study was designed to quantify the insulin response to arg and glgn and determine test repeatability and tolerability.	Arginine	60-63	insulin	Homo sapiens	40-47
25117899-4	2014	We used the H2CN NMR pulse sequence to detect heparin binding through the side-chain resonances Hepsilon-Cepsilon-Nzeta of Lys and Hdelta-Cdelta-Nepsilon of Arg in the two proteins of hepatoma-derived growth factor (HDGF) and basic fibroblast growth factor (FGF2).	Arginine	157-160	fibroblast growth factor 2	Homo sapiens	258-262
25181320-9	2014	The mRNA expression of mechanistic target of rapamycin (mTOR) complex 1 pathway genes (mTOR and RPS6KB1) and the anti-apoptosis gene Bcl-2 quadratically responded to increasing dietary Arg supplementation (P&lt; 0 05).	Arginine	185-188	mechanistic target of rapamycin	Gallus gallus	23-54
25181320-9	2014	The mRNA expression of mechanistic target of rapamycin (mTOR) complex 1 pathway genes (mTOR and RPS6KB1) and the anti-apoptosis gene Bcl-2 quadratically responded to increasing dietary Arg supplementation (P&lt; 0 05).	Arginine	185-188	mechanistic target of rapamycin	Gallus gallus	56-60
25181320-9	2014	The mRNA expression of mechanistic target of rapamycin (mTOR) complex 1 pathway genes (mTOR and RPS6KB1) and the anti-apoptosis gene Bcl-2 quadratically responded to increasing dietary Arg supplementation (P&lt; 0 05).	Arginine	185-188	mechanistic target of rapamycin	Gallus gallus	87-91
25181320-9	2014	The mRNA expression of mechanistic target of rapamycin (mTOR) complex 1 pathway genes (mTOR and RPS6KB1) and the anti-apoptosis gene Bcl-2 quadratically responded to increasing dietary Arg supplementation (P&lt; 0 05).	Arginine	185-188	BCL2, apoptosis regulator	Gallus gallus	133-138
25181320-10	2014	These results indicate that dietary Arg supplementation attenuates intestinal mucosal disruption in coccidiosis-challenged chickens probably through suppressing TLR4 and activating mTOR complex 1 pathways.	Arginine	36-39	mechanistic target of rapamycin	Gallus gallus	181-185
25170076-5	2014	First, we generated high purity apoA-I from human plasma, using thiophilic interaction chromatography followed by enzymatic digestion specifically at lysine or arginine residues.	Arginine	160-168	apolipoprotein A1	Homo sapiens	32-38
25122770-5	2014	A new intercomplex contact was found between SH3 Glu-93, and Nef Arg-105.	Arginine	65-68	S100 calcium binding protein B	Homo sapiens	61-64
25335675-0	2014	Effect of L-arginine supplementation on insulin resistance and adipocitokines levels in head and neck cancer non diabetic patients after surgery.	Arginine	10-20	insulin	Homo sapiens	40-47
25335675-1	2014	INTRODUCTION: Previous studies have found that L-arginine induced beneficial effects over insulin resistance both in type 2 diabetes mellitus patients and healthy individuals.	Arginine	47-57	insulin	Homo sapiens	90-97
25335675-2	2014	The aim of our study was to investigate whether an L-arginine enteral supplementation (20 g per day) in head and neck cancer patients could modify insulin resistance, leptin and adiponectin levels after surgery.	Arginine	51-61	insulin	Homo sapiens	147-154
25335675-2	2014	The aim of our study was to investigate whether an L-arginine enteral supplementation (20 g per day) in head and neck cancer patients could modify insulin resistance, leptin and adiponectin levels after surgery.	Arginine	51-61	adiponectin, C1Q and collagen domain containing	Homo sapiens	178-189
25335675-6	2014	Insulin levels UI/L (-0.21+/-0.18) and HOMA units (-0.07+/-0.13) decreased in the arginine group.	Arginine	82-90	insulin	Homo sapiens	0-7
25335675-7	2014	Adiponectin levels (+1.8+/-2.3ng/ml) increased in the arginine group.	Arginine	54-62	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
25335675-8	2014	CONCLUSION: Short-term enteral L-arginine therapy addeded to usual enteral nutrition of patients affected by head and neck cancer and surgery without diabetes mellitus type 2 is able to improve insulin resistance and adiponectin levels.	Arginine	31-41	insulin	Homo sapiens	194-201
25335675-8	2014	CONCLUSION: Short-term enteral L-arginine therapy addeded to usual enteral nutrition of patients affected by head and neck cancer and surgery without diabetes mellitus type 2 is able to improve insulin resistance and adiponectin levels.	Arginine	31-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	217-228
32261813-4	2014	Sulfated chitosan-arginine was found to bind and signal fibroblast growth factor 2.	Arginine	18-26	fibroblast growth factor 2	Homo sapiens	56-82
25224370-11	2014	Arg can protect against colonic inflammation; an effect that probably be attributed to its nitric oxide-donating property, resulting in modulatory effects on the expression of NF-kappaB/p65 in the colon tissues.	Arginine	0-3	synaptotagmin 1	Rattus norvegicus	186-189
25153662-8	2014	Moreover, this association was enhanced when combined with HPV-16 seropositivity and p53 Arg/Arg or Arg/Pro genotypes.	Arginine	89-92	tumor protein p53	Homo sapiens	85-88
25153662-8	2014	Moreover, this association was enhanced when combined with HPV-16 seropositivity and p53 Arg/Arg or Arg/Pro genotypes.	Arginine	93-96	tumor protein p53	Homo sapiens	85-88
25153662-8	2014	Moreover, this association was enhanced when combined with HPV-16 seropositivity and p53 Arg/Arg or Arg/Pro genotypes.	Arginine	93-96	tumor protein p53	Homo sapiens	85-88
24697328-0	2014	L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway.	Arginine	0-10	interleukin 2	Homo sapiens	66-79
25224370-0	2014	L-arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of nuclear factor-kappaB/p65.	Arginine	0-10	synaptotagmin 1	Rattus norvegicus	138-141
24697328-11	2014	Exogenous l-arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway.	Arginine	10-20	interleukin 2	Homo sapiens	79-92
25345946-5	2014	Combined analysis of the polymorphisms showed that the percentage of +33371Gln/Arg (A/A)/CYP2E1-Rsa I (c2/c2) was 32.	Arginine	79-82	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	89-95
24178590-8	2014	When FN molecules adsorbed onto the surfaces of TiNTs, their RGD (Arg-Gly-Asp) sites were easily exposed to outside and more likely to bond with the fibronectin receptors, in turn regulating the cellular behaviors.	Arginine	66-69	fibronectin 1	Homo sapiens	5-7
24178590-8	2014	When FN molecules adsorbed onto the surfaces of TiNTs, their RGD (Arg-Gly-Asp) sites were easily exposed to outside and more likely to bond with the fibronectin receptors, in turn regulating the cellular behaviors.	Arginine	66-69	fibronectin 1	Homo sapiens	149-160
25478411-4	2014	RESULTS: The cord serum NO levels (mumol/lt) showed a significant increase &amp; SOD (U/ml) &amp; GSH (U/lt) values were increased in newborns to mothers diagnosed with IUGR after treatment with L-arginine.	Arginine	195-205	superoxide dismutase 1	Homo sapiens	81-84
25236163-5	2014	When added from Days 1 to 8, 50 mM L-arginine decreased blastocyst rates (P &lt; 0.001); in contrast, when added from Days 5 to 8, 1 mM L-arginine improved embryo hatching rates (P &lt; 0.05) and quality (P &lt; 0.05) as well as increased POU5F1 gene expression (P &lt; 0.05) as compared to the untreated control.	Arginine	136-146	POU domain, class 5, transcription factor 1	Bos taurus	239-245
25345946-8	2014	9527, P&lt;0.01), and statistical analysis suggested an interaction between smoking and +33371Gln/Arg (A/A)/CYP2E1-Rsa I (c2/c2) to increase the risk of NAFLD (OR=34.6764, 95% CI=18.9076-61.5825).	Arginine	98-101	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	108-114
25239335-15	2014	ARG/ADMA decreased proportional to greater oxygen debt during hemorrhage and greater IL-6 levels with fluid resuscitation.	Arginine	0-3	interleukin-6	Sus scrofa	85-89
24096994-9	2014	After GHRH-ARG the mean GH peak levels (GH-P) and GH response (as Area Under Curve, GH-AUC) were lower in SH+ than in SH- patients (15.2 +- 8.1 vs 44.5 +- 30.9 mug/L, P = 0.004 and 1,418 +- 803 vs 4,028 +- 2,476 mug/L/120 min, P = 0.002, respectively), after adjusting for age and BMI.	Arginine	11-14	growth hormone releasing hormone	Homo sapiens	6-10
25239335-17	2014	The ARG/ADMA ratio reflects both of these parameters and corresponds to the increase in IL-6 and persistent ischemia after resuscitation.	Arginine	4-7	interleukin-6	Sus scrofa	88-92
25226365-5	2014	In those subjects we assessed acute insulin responses to arginine, a glucose clamp study, whole-body fat mass and fat-free mass.	Arginine	57-65	insulin	Homo sapiens	36-43
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Arginine	47-50	tumor protein p53	Homo sapiens	19-22
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
25034526-6	2014	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in lung cancer were 25.5, 37.7, and 36.8 %, respectively; frequencies in the controls were 53.4, 30.2, and 16.4 %, respectively (p &lt; 0.01).	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
25193696-8	2014	However, three of these residues (Arg(5), Tyr(10) and His(13)) identified in this study are all absent in rodents, where rodent Abeta-heme complex lacks peroxidase activity and it does not show AD, implicating the novel significance of these residues as well as human Abeta-heme peroxidase in the pathology of AD.	Arginine	34-37	amyloid beta precursor protein	Homo sapiens	128-133
25201986-3	2014	The production of NO by granuloma macrophages expressing nitric oxide synthase-2 (NOS2) via l-arginine and oxygen is a key protective mechanism against mycobacteria.	Arginine	92-102	nitric oxide synthase 2, inducible	Mus musculus	82-86
25226365-7	2014	The presence of islet Ab correlated with severely impaired beta-cell function as demonstrated by remarkably low acute insulin response to arginine (AIR) when compared to that of the Ab negative group.	Arginine	138-146	insulin	Homo sapiens	118-125
24748005-5	2014	The deletion of the arginine cluster and the mutation of acidic residues to basic residues are predicted to delay disease development by abolishing CD4 downmodulation and causing diminution of major histocompatibility complex class I (MHC-I) downregulation, respectively.	Arginine	20-28	CD4 molecule	Homo sapiens	148-151
25030615-1	2014	Peptide-like compounds containing an arginine have been shown to bind and stabilize the central helix of the Alzheimer"s disease related amyloid-beta peptide (Abeta) in an alpha-helical conformation, thereby delaying its aggregation into cytotoxic species.	Arginine	37-45	amyloid beta precursor protein	Homo sapiens	159-164
25212999-2	2014	Here, we show that a neurostimulant, para-chloroamphetamine (PCA), specifically inhibits the Arg/N-end rule pathway, delaying the degradation of its artificial and physiological substrates, including regulators of G protein signaling 4 (RGS4), in vitro and in cultured cells.	Arginine	93-96	regulator of G-protein signaling 4	Mus musculus	200-235
25212999-2	2014	Here, we show that a neurostimulant, para-chloroamphetamine (PCA), specifically inhibits the Arg/N-end rule pathway, delaying the degradation of its artificial and physiological substrates, including regulators of G protein signaling 4 (RGS4), in vitro and in cultured cells.	Arginine	93-96	regulator of G-protein signaling 4	Mus musculus	237-241
25043977-4	2014	Second, we demonstrated that two positively charged B-chain Arg residues (B13Arg and B23Arg) in human INSL5 were involved in receptor binding and activation.	Arginine	60-63	insulin like 5	Homo sapiens	102-107
24858214-1	2014	Nitric oxide (NO) can be generated by two-step reduction pathway in which nitrate is converted first into nitrite and then into NO via several mechanisms, as well as from arginine by endogenous nitric oxide synthase (NOS).	Arginine	171-179	nitric oxide synthase 2	Homo sapiens	194-215
24793417-3	2014	Since arginine is the obliged substrate of iNOS (inducible nitric oxide synthase), the enzyme that produces large amount of NO, the aim of this work is to investigate arginine metabolic pathways in RAW264.7 murine macrophages after treatment with PT-gliadin (PTG) in the absence and in the presence of IFNgamma.	Arginine	6-14	nitric oxide synthase 2, inducible	Mus musculus	43-47
24793417-3	2014	Since arginine is the obliged substrate of iNOS (inducible nitric oxide synthase), the enzyme that produces large amount of NO, the aim of this work is to investigate arginine metabolic pathways in RAW264.7 murine macrophages after treatment with PT-gliadin (PTG) in the absence and in the presence of IFNgamma.	Arginine	6-14	nitric oxide synthase 2, inducible	Mus musculus	49-80
24793417-3	2014	Since arginine is the obliged substrate of iNOS (inducible nitric oxide synthase), the enzyme that produces large amount of NO, the aim of this work is to investigate arginine metabolic pathways in RAW264.7 murine macrophages after treatment with PT-gliadin (PTG) in the absence and in the presence of IFNgamma.	Arginine	6-14	interferon gamma	Mus musculus	302-310
24793417-3	2014	Since arginine is the obliged substrate of iNOS (inducible nitric oxide synthase), the enzyme that produces large amount of NO, the aim of this work is to investigate arginine metabolic pathways in RAW264.7 murine macrophages after treatment with PT-gliadin (PTG) in the absence and in the presence of IFNgamma.	Arginine	167-175	nitric oxide synthase 2, inducible	Mus musculus	43-47
24793417-3	2014	Since arginine is the obliged substrate of iNOS (inducible nitric oxide synthase), the enzyme that produces large amount of NO, the aim of this work is to investigate arginine metabolic pathways in RAW264.7 murine macrophages after treatment with PT-gliadin (PTG) in the absence and in the presence of IFNgamma.	Arginine	167-175	nitric oxide synthase 2, inducible	Mus musculus	49-80
24799458-1	2014	This study demonstrates how the multimodal Capto adhere resin can be used in concert with calcium chloride or arginine hydrochloride as mobile phase modifiers to create a highly selective purification process for a modified human growth hormone.	Arginine	110-132	growth hormone 1	Homo sapiens	230-244
25025520-2	2014	The arginine allele at codon 72 in p53 tumor suppressor gene has been reported to be a risk-factor in different ethnic groups.	Arginine	4-12	tumor protein p53	Homo sapiens	35-38
24969577-4	2014	Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the beta-cell secretory capacity.	Arginine	27-35	insulin	Homo sapiens	6-13
24969577-4	2014	Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the beta-cell secretory capacity.	Arginine	181-189	insulin	Homo sapiens	198-205
24969577-4	2014	Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the beta-cell secretory capacity.	Arginine	181-189	insulin	Homo sapiens	198-205
24969577-4	2014	Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the beta-cell secretory capacity.	Arginine	181-189	insulin	Homo sapiens	198-205
24969577-4	2014	Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the beta-cell secretory capacity.	Arginine	181-189	insulin	Homo sapiens	198-205
25149676-6	2014	+1245 MT1A G+ (Arginine) genotype showed higher plasma AGEs and ROS production in peripheral blood mononuclear cells (PBMCs) than G- (Lysine) one at the baseline.	Arginine	15-23	metallothionein 1A	Homo sapiens	6-10
24970008-14	2014	MIBG inhibited the migration and invasion of HepG2 cells, possibly through the inhibition of arginine-specific single-adenosine diphosphate ribosylation and the suppression of the protein expression of integrin alpha7beta1, FAK and PI3K and the secretion of uPA, leading to reduced invasion by HepG2 cells.	Arginine	93-101	plasminogen activator, urokinase	Homo sapiens	258-261
25536560-2	2014	To set of p53-mediated apoptosis gene polymorphisms (TP53 codon 72 Arg/Pro, r21 codon 31 Ser/Arg, MDM2 SNP309) for the occurrence of CLL in patients who were exposed to ionizing radiation (IR) from the Chornobyl accident.	Arginine	67-70	tumor protein p53	Homo sapiens	10-13
25536560-2	2014	To set of p53-mediated apoptosis gene polymorphisms (TP53 codon 72 Arg/Pro, r21 codon 31 Ser/Arg, MDM2 SNP309) for the occurrence of CLL in patients who were exposed to ionizing radiation (IR) from the Chornobyl accident.	Arginine	93-96	tumor protein p53	Homo sapiens	10-13
25536560-7	2014	The distribution of genotypes in patients with CLL did not differ from controls, except for reduced the frequency of homozygotes Arg/Arg TP53 among patients with CLL (p = 0.01).	Arginine	129-132	tumor protein p53	Homo sapiens	137-141
25536560-7	2014	The distribution of genotypes in patients with CLL did not differ from controls, except for reduced the frequency of homozygotes Arg/Arg TP53 among patients with CLL (p = 0.01).	Arginine	133-136	tumor protein p53	Homo sapiens	137-141
25061098-10	2014	Thus, the adverse effect of MAO-NOS3 to reduce NO generation and the transport of arginine and ornithine into conceptuses is central to an explanation for failure of normal development of MAO-NOS3, compared to control conceptuses.	Arginine	82-90	nitric oxide synthase 3	Homo sapiens	32-36
25061098-12	2014	Our data suggest that NOS3 is the key enzyme for NO production by conceptus Tr and that this protein also regulates the availability of arginine in conceptus tissues for synthesis of polyamines that are essential for conceptus survival and development.	Arginine	136-144	nitric oxide synthase 3	Homo sapiens	22-26
24424122-6	2014	Our analysis revealed that 23/108 (21.3%) of E-cadherin-mutant families carried nonsense mutations that could be potentially corrected by eight suppressor-tRNAs, and arginine was the most frequently affected amino acid.	Arginine	166-174	cadherin 1	Homo sapiens	45-55
24561640-7	2014	RESULTS: L-Arg significantly inhibited growth of SCG-7901 gastric cancer cells and downregulated expression of antiapoptotic gene Bcl-2 and survivin.	Arginine	9-14	BCL2 apoptosis regulator	Homo sapiens	130-135
24561640-8	2014	By contrast, expression of p53 was upregulated by L-Arg.	Arginine	50-55	tumor protein p53	Homo sapiens	27-30
24561640-9	2014	CONCLUSION: Regulation of apoptosis by L-Arg via downregulation of antiapoptotic proteins Bcl-2 and surviving, and upregulation of proapoptotic protein p53 may represent the mechanism behind antitumor effects of L-Arg.	Arginine	39-44	BCL2 apoptosis regulator	Homo sapiens	90-95
25012667-1	2014	Protein arginine methyltransferase 5 (PRMT5), a protein arginine methyltransferase that catalyzes the symmetrical dimethylation of arginine residues within target proteins, has been implicated in many essential cellular processes ranging from the regulation of gene expression to cell proliferation and differentiation.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
24853465-3	2014	In the course of model experiments, a striking potential of the amino acids L-arginine (Arg) and L-lysine (Lys) and a number of positively charged peptides to induce formation of heterogenic supramolecular structures of insulin was demonstrated under environment conditions where the protein aggregation in their absence was not observed.	Arginine	76-86	insulin	Homo sapiens	220-227
25177931-6	2014	TP53 72 showed the following genotypic distribution: the control group was 29.75% homozygous wild-type (Arg), 47.11% heterozygous (Arg-Pro), and 23.14% homozygous variant (Pro).	Arginine	104-107	tumor protein p53	Homo sapiens	0-4
24853465-3	2014	In the course of model experiments, a striking potential of the amino acids L-arginine (Arg) and L-lysine (Lys) and a number of positively charged peptides to induce formation of heterogenic supramolecular structures of insulin was demonstrated under environment conditions where the protein aggregation in their absence was not observed.	Arginine	88-91	insulin	Homo sapiens	220-227
25177931-6	2014	TP53 72 showed the following genotypic distribution: the control group was 29.75% homozygous wild-type (Arg), 47.11% heterozygous (Arg-Pro), and 23.14% homozygous variant (Pro).	Arginine	131-134	tumor protein p53	Homo sapiens	0-4
25177931-8	2014	Only one patient had the homozygous TP53 248 genotype (Arg-Trp/Gln); all other patients were homozygous wild-type in both the control and endometriosis groups (P = 0.51; NS).	Arginine	55-58	tumor protein p53	Homo sapiens	36-40
25148519-10	2014	The two sites within proSAAS that are known to be efficiently cleaved by furin were altered by site-directed mutagenesis to convert the P4 Arg into Lys; this change converts the sequences from furin consensus sites into prohormone convertase consensus sites.	Arginine	139-142	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	21-28
25149450-4	2014	While LAP1 lacks canonical nucleotide binding motifs, its strictly conserved arginine 563 is positioned exactly where the arginine finger of canonical AAA+ ATPases is found.	Arginine	77-85	torsin 1A interacting protein 1	Homo sapiens	6-10
25149450-6	2014	The experimental data show that mutation of arginine 563 in LAP1 reduces its ability to stimulate TorsinA ATPase hydrolysis.	Arginine	44-52	torsin 1A interacting protein 1	Homo sapiens	60-64
25068569-5	2014	Of interest are two arginine residues, R181 and R274, that are highly conserved in Vangl protein homologues and found to be independently mutated in VANGL1 (R181Q and R274Q) and VANGL2 (R177H and R270H) in human cases of NTDs.	Arginine	20-28	VANGL planar cell polarity protein 2	Homo sapiens	178-184
25033468-1	2014	In healthy human subjects, less than 0.2% of l-arginine is converted to l-citrulline and nitric oxide (NO) by NO synthases (NOS), a metabolic pathway present in all cell types.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	110-122
25258482-4	2014	The G915C polymorphism changes codon 25 which encodes arginine into proline in the signal peptide of TGF-beta1.	Arginine	54-62	transforming growth factor beta 1	Homo sapiens	101-110
25258482-7	2014	The arginine substitution into proline decreased the polarity of the signal peptide for TGF-beta1.	Arginine	4-12	transforming growth factor beta 1	Homo sapiens	88-97
25099799-8	2014	An in vitro assessment of tracer uptake suggests that the IC pocket residue Arg-143 plays an essential role on the modulation of the hCx26 hemichannel permeability.	Arginine	76-79	gap junction protein beta 2	Homo sapiens	133-138
24943844-5	2014	Substitution of K45 with arginine reduces SUMOylation, whereas substitution of K71 or both K45 and K71 with arginine abolishes SUMOylation, with more of the double mutant GPS2 appearing in the cytosol than in the nucleus compared with wild type and the two-single-mutant GPS2.	Arginine	108-116	keratin 71	Homo sapiens	99-102
25152637-4	2014	It is derived from L-arginine that selectively and reversibly inhibits thrombin, both clot-bound and free, at the catalytic site.	Arginine	19-29	coagulation factor II, thrombin	Homo sapiens	71-79
25099801-7	2014	Residues lining this cavity in EAAT1, including Ser-366, Leu-369, Phe-373, Arg-388, Pro-392, and Thr-396, were mutated to small hydrophobic residues.	Arginine	75-78	solute carrier family 1 member 3	Homo sapiens	31-36
24721162-0	2014	Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.	Arginine	0-8	signal transducer and activator of transcription 3	Homo sapiens	51-56
24705954-2	2014	Interindividual differences in activity of PON1 (catalytic bioscavenger) and substrate specificity are strongly associated with the substitution of two amino acids: Leu/Met (L/M) at position 55 (rs854560) and Gln/Arg (Q/R) at position 192 (rs662).	Arginine	213-216	paraoxonase 1	Homo sapiens	43-47
24721162-0	2014	Arginine residues within the DNA binding domain of STAT3 promote intracellular shuttling and phosphorylation of STAT3.	Arginine	0-8	signal transducer and activator of transcription 3	Homo sapiens	112-117
24721162-2	2014	STAT3 harbors non-acetylatable arginine moieties at the corresponding sites R414 and R417.	Arginine	31-39	signal transducer and activator of transcription 3	Homo sapiens	0-5
24721162-4	2014	Here, we show that an arginine-glutamine-exchange at the STAT3 moieties R414 and R417 (R414Q and R417Q) reduces cytokine-dependent tyrosine phosphorylation of STAT3.	Arginine	22-30	signal transducer and activator of transcription 3	Homo sapiens	57-62
24721162-4	2014	Here, we show that an arginine-glutamine-exchange at the STAT3 moieties R414 and R417 (R414Q and R417Q) reduces cytokine-dependent tyrosine phosphorylation of STAT3.	Arginine	22-30	signal transducer and activator of transcription 3	Homo sapiens	159-164
24721162-11	2014	We further analyzed a STAT3 arginine-lysine-exchange mutant (R414K/R417K).	Arginine	28-36	signal transducer and activator of transcription 3	Homo sapiens	22-27
24777312-1	2014	The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called C5L2).	Arginine	121-124	complement C5a receptor 1	Homo sapiens	113-116
24859349-8	2014	This SS driven cleavage is blocked by a deleting amino acids 55-81 as well as simply mutating arginine residues at positions 80 and 81 to alanine of EpCAM.	Arginine	94-102	epithelial cell adhesion molecule	Homo sapiens	149-154
24777312-1	2014	The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called C5L2).	Arginine	121-124	complement C5a receptor 1	Homo sapiens	178-190
24777312-1	2014	The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called C5L2).	Arginine	121-124	complement C5a receptor 2	Homo sapiens	254-258
24777312-3	2014	A bioluminescence resonance energy transfer (BRET) assay was used to assess the recruitment of beta-arrestins by C5a and C5a-des Arg at the C5a1 and C5a2 receptors.	Arginine	129-132	complement C5a receptor 1	Homo sapiens	121-124
24777312-1	2014	The complement system is a major component of our innate immune system, in which the complement proteins C5a and C5a-des Arg bind to two G-protein-coupled receptors: namely, the C5a receptor (C5a1) and C5a receptor like-2 receptor (C5a2, formerly called C5L2).	Arginine	121-124	complement C5a receptor 1	Homo sapiens	202-214
24777312-6	2014	Interestingly, both C5a and C5a-des Arg exhibited higher potency for beta-arrestin 2 recruitment via C5a2, indicating preference for C5a2 over C5a1.	Arginine	36-39	complement C5a receptor 1	Homo sapiens	28-31
24777312-6	2014	Interestingly, both C5a and C5a-des Arg exhibited higher potency for beta-arrestin 2 recruitment via C5a2, indicating preference for C5a2 over C5a1.	Arginine	36-39	arrestin beta 2	Homo sapiens	69-84
23475592-2	2014	This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms.	Arginine	27-35	tumor protein p53	Homo sapiens	76-79
24578133-6	2014	Furthermore, we identified arginines in the basic domain (RKKRRQRRR) of Tat as essential for (1) targeting Tat to LRs, (2) Tat-mediated increases in the expression of Rho-A and matrix metalloproteinase-9 in LRs, and (3) Tat-mediated enhancement of FGF-2 signaling in human podocytes and HIV-transgenic mouse kidneys and the exacerbation of renal lesions in these mice.	Arginine	27-36	ras homolog family member A	Homo sapiens	167-203
24578133-6	2014	Furthermore, we identified arginines in the basic domain (RKKRRQRRR) of Tat as essential for (1) targeting Tat to LRs, (2) Tat-mediated increases in the expression of Rho-A and matrix metalloproteinase-9 in LRs, and (3) Tat-mediated enhancement of FGF-2 signaling in human podocytes and HIV-transgenic mouse kidneys and the exacerbation of renal lesions in these mice.	Arginine	27-36	fibroblast growth factor 2	Homo sapiens	248-253
24920161-6	2014	Through the identification of PARP-1 in vitro automodification sites as well as endogenous ADP-ribosylation sites from whole cells, we have shown that ADP-ribose can exist on adjacent amino acid residues as well as both lysine and arginine in addition to known acidic modification sites.	Arginine	231-239	poly(ADP-ribose) polymerase 1	Homo sapiens	30-36
25434084-6	2014	After pretreated L-Arg, expressions of TNF-alpha and IL-1beta mRNA were markedly increased (P&lt;0.05).	Arginine	17-22	tumor necrosis factor	Rattus norvegicus	39-48
25434084-6	2014	After pretreated L-Arg, expressions of TNF-alpha and IL-1beta mRNA were markedly increased (P&lt;0.05).	Arginine	17-22	interleukin 1 beta	Rattus norvegicus	53-61
24895248-5	2014	Standard calibration curves revealed that the assay was linear in the concentration range 0.2-1.0 muM for methylated arginines and 40-200 muM for L-arginine.	Arginine	117-126	latexin	Homo sapiens	98-101
24895248-5	2014	Standard calibration curves revealed that the assay was linear in the concentration range 0.2-1.0 muM for methylated arginines and 40-200 muM for L-arginine.	Arginine	146-156	latexin	Homo sapiens	138-141
23475592-2	2014	This SNP encodes either an arginine or proline at position 72 (R72P) of the p53 protein, which can alter the apoptotic activity of p53 via transcriptional and non-transcriptional mechanisms.	Arginine	27-35	tumor protein p53	Homo sapiens	131-134
25220593-9	2014	Knockdown of LCE1 by specific small interfering RNAs significantly increased the symmetric dimethylation of histone H3 arginine 8, a substrate of PRMT5, and overexpression of LCE1F remarkably decreased its methylation level.	Arginine	119-127	protein arginine methyltransferase 5	Homo sapiens	146-151
24782034-9	2014	The most frequent genotype in both CIN(+) and CIN(-) patients was Arg/Pro TP53 codon 72 and A1A1 for 16-bp Del in intron 3.	Arginine	66-69	tumor protein p53	Homo sapiens	74-78
24907272-6	2014	Furthermore, we proved that arginines 73 and 74 within the ARM of RNF4 are required for efficient recruitment to KAP1 or accelerated degradation of promyelocytic leukemia protein (PML) under stress.	Arginine	28-37	tripartite motif containing 28	Homo sapiens	113-117
29259398-9	2015	Conclusions: We conclude: the p53 codon 72*Arg/*Arg genotype, with its strong apoptotic effects, negatively influences spermatozoa motility and male fertility.	Arginine	43-46	tumor protein p53	Homo sapiens	30-33
29259398-9	2015	Conclusions: We conclude: the p53 codon 72*Arg/*Arg genotype, with its strong apoptotic effects, negatively influences spermatozoa motility and male fertility.	Arginine	48-51	tumor protein p53	Homo sapiens	30-33
24907272-0	2014	An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.	Arginine	3-11	tripartite motif containing 28	Homo sapiens	185-189
24814653-0	2014	Dual effect of arginine on aggregation of phosphorylase kinase.	Arginine	15-23	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	42-62
24907272-0	2014	An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.	Arginine	3-11	tripartite motif containing 28	Homo sapiens	191-197
25051975-8	2014	In these conditions, the inhibition of mTOR led to a significant up-regulation of iNOS, and in parallel to the down-regulation of both ARG and IL-10 gene expression.	Arginine	135-138	mechanistic target of rapamycin kinase	Homo sapiens	39-43
25076951-0	2014	BASIC AMINO ACID CARRIER 2 gene expression modulates arginine and urea content and stress recovery in Arabidopsis leaves.	Arginine	53-61	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-26
25076951-4	2014	When BAC2 is overexpressed in vivo, it triggers catabolism of arginine, a basic amino acid, leading to arginine depletion and urea accumulation in leaves.	Arginine	62-70	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	5-9
25076951-4	2014	When BAC2 is overexpressed in vivo, it triggers catabolism of arginine, a basic amino acid, leading to arginine depletion and urea accumulation in leaves.	Arginine	103-111	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	5-9
25076951-8	2014	The expression of genes encoding stress-related transcription factors (TF), arginine metabolism enzymes, and transporters is particularly disturbed in bac2-1, and in control conditions, the bac2-1 transcriptome has some hallmarks of a wild-type stress transcriptome.	Arginine	76-84	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	151-155
25076951-9	2014	The BAC2 carrier is therefore involved in controlling the balance of arginine and arginine-derived metabolites and its associated amino acid metabolism is physiologically important in equipping plants to respond to and recover from stress.	Arginine	69-77	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	4-8
25076951-9	2014	The BAC2 carrier is therefore involved in controlling the balance of arginine and arginine-derived metabolites and its associated amino acid metabolism is physiologically important in equipping plants to respond to and recover from stress.	Arginine	82-90	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	4-8
25089090-2	2014	The PON1 gene contains several polymorphisms including a glutamine (Q) to arginine (R) transition at position 192 encoding circulating allozymes with higher antioxidant activity that might influence both parameters.	Arginine	74-82	paraoxonase 1	Homo sapiens	4-8
25054323-3	2014	Arginine potently induced the expression of type Ialpha1 collagen, osteocalcin, and ALP in a dose-dependent manner without causing cytotoxicity.	Arginine	0-8	bone gamma-carboxyglutamate protein	Homo sapiens	67-78
25054323-4	2014	Arginine significantly increased the mRNA expression of the osteogenic transcription factors runt-related transcription factor 2 (Runx2), DIx5, and osterix.	Arginine	0-8	RUNX family transcription factor 2	Homo sapiens	130-135
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	204-252
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	254-263
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	CCAAT enhancer binding protein alpha	Homo sapiens	266-302
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	CCAAT enhancer binding protein alpha	Homo sapiens	304-314
25054323-6	2014	This effect was associated with increased expression of Wnt5a, and nuclear factor of activated T-cells (NFATc), and was abrogated by antagonists of Wnt and NFATc, which indicated a role of Wnt and NFATc signaling in the switch from adipogenesis to osteoblastogenesis induced by arginine.	Arginine	278-286	Wnt family member 5A	Homo sapiens	56-61
25054323-7	2014	In conclusion, this is the first report of the dual action of arginine in promoting osteogenesis and inhibiting adipocyte formation through involving Wnt5a and NFATc signaling pathway.	Arginine	62-70	Wnt family member 5A	Homo sapiens	150-155
24992688-0	2014	A novel arginine to tryptophan (R144W) mutation in troponin T (cTnT) gene in an indian multigenerational family with dilated cardiomyopathy (FDCM).	Arginine	8-16	troponin T2, cardiac type	Homo sapiens	63-67
24992688-4	2014	Interestingly, a novel R144W mutation, that substitutes polar-neutral tryptophan for a highly conserved basic arginine in cTnT, altering the charge drastically, was identified in a DCM, with a family history of sudden-cardiac death (SCD).	Arginine	110-118	troponin T2, cardiac type	Homo sapiens	122-126
24686079-5	2014	Stimulation with Apelin-13 and des -Arg(9)-BK enhanced the phosphorylation of eNOS in HUVECs, which could be dampened by the knockdown of APJ or B1R, indicating the co-existence of APJ and B1R is critical for eNOS phosphorylation in HUVECs.	Arginine	36-39	bradykinin receptor B1	Homo sapiens	145-148
24686079-5	2014	Stimulation with Apelin-13 and des -Arg(9)-BK enhanced the phosphorylation of eNOS in HUVECs, which could be dampened by the knockdown of APJ or B1R, indicating the co-existence of APJ and B1R is critical for eNOS phosphorylation in HUVECs.	Arginine	36-39	bradykinin receptor B1	Homo sapiens	189-192
24527810-10	2014	Here, we show that HPCs secrete arginase, an enzyme that scavenges l-arginine, leading to metabolites that down-regulate CD3 zeta chain.	Arginine	67-77	CD247 antigen	Mus musculus	121-124
24814653-3	2014	The investigation is concerned with the effects of arginine on protein-protein interactions using phosphorylase kinase (PhK) as an example.	Arginine	51-59	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	98-118
24814653-3	2014	The investigation is concerned with the effects of arginine on protein-protein interactions using phosphorylase kinase (PhK) as an example.	Arginine	51-59	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	120-123
24814653-5	2014	On the basis of light scattering measurements it was shown that arginine induced aggregation of Ca(2+)-free PhK.	Arginine	64-72	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	108-111
24814653-6	2014	On the contrary, when studying Ca(2+), Mg(2+)-induced aggregation of PhK at 37 C, the protective effect of arginine was demonstrated.	Arginine	107-115	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	69-72
24814653-7	2014	The data on analytical ultracentrifugation are indicative of disruption of PhK hexadecameric structure under the action of arginine.	Arginine	123-131	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	75-78
24047476-6	2014	Our results showed a significantly lower frequency of the BCL2L10-21Arg allele in patients with t-MN and de novo MDS compared to controls (Leu/Arg + Arg/Arg: 50.6% vs. 65.9%, p = 0.017 and 45.8% vs. 65.9%, p = 0.0003, respectively).	Arginine	68-71	BCL2 like 10	Homo sapiens	58-65
24047476-6	2014	Our results showed a significantly lower frequency of the BCL2L10-21Arg allele in patients with t-MN and de novo MDS compared to controls (Leu/Arg + Arg/Arg: 50.6% vs. 65.9%, p = 0.017 and 45.8% vs. 65.9%, p = 0.0003, respectively).	Arginine	143-146	BCL2 like 10	Homo sapiens	58-65
24047476-6	2014	Our results showed a significantly lower frequency of the BCL2L10-21Arg allele in patients with t-MN and de novo MDS compared to controls (Leu/Arg + Arg/Arg: 50.6% vs. 65.9%, p = 0.017 and 45.8% vs. 65.9%, p = 0.0003, respectively).	Arginine	143-146	BCL2 like 10	Homo sapiens	58-65
24914981-4	2014	The function of anaphylatoxins is regulated by circulating carboxypeptidases that remove their C-terminal arginine residue, yielding C3a-desArg and C5a-desArg.	Arginine	106-114	complement C5a receptor 1	Homo sapiens	148-151
24967964-10	2014	Through both NO synthesis inhibition (using L-arginine deprivation, arginine is a substrate for NO synthase (NOS), which catalyzes NO synthesis; using L-Name, a NOS inhibitor) and NO donor (using DETA-NONOate) analysis, we show that NO not only positively regulates tumor growth but also inhibits mitochondrial respiration in OVCA cells, shifting these cells towards glycolysis to maintain their ATP production.	Arginine	44-54	nitric oxide synthase 2	Homo sapiens	96-107
24967964-10	2014	Through both NO synthesis inhibition (using L-arginine deprivation, arginine is a substrate for NO synthase (NOS), which catalyzes NO synthesis; using L-Name, a NOS inhibitor) and NO donor (using DETA-NONOate) analysis, we show that NO not only positively regulates tumor growth but also inhibits mitochondrial respiration in OVCA cells, shifting these cells towards glycolysis to maintain their ATP production.	Arginine	46-54	nitric oxide synthase 2	Homo sapiens	96-107
24814345-4	2014	In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively.	Arginine	36-44	ribosomal protein L27a	Homo sapiens	248-254
24870066-3	2014	Here, we used both experimental and theoretical approaches to investigate the interactions of SWCNTs with human serum albumin (HSA, one of the most abundant proteins in blood circulation) and found that the binding was involved in the electrostatic interactions of positively charged Arg residues of HSA with the carboxyls on the nanotubes, along with the pi-pi stacking interactions between SWCNTs and aromatic Tyr residues in HSA.	Arginine	284-287	albumin	Homo sapiens	112-125
24901643-8	2014	The N-terminal amino acid sequence CDD which is conserved between Kv2 and KvS subunits appeared to be a key determinant since charge reversals with arginine substitutions abolished the interaction between the N-terminus of Kv2.1 and the C-terminus of both Kv2.1 and Kv6.4.	Arginine	148-156	natriuretic peptide A	Homo sapiens	35-38
24901643-8	2014	The N-terminal amino acid sequence CDD which is conserved between Kv2 and KvS subunits appeared to be a key determinant since charge reversals with arginine substitutions abolished the interaction between the N-terminus of Kv2.1 and the C-terminus of both Kv2.1 and Kv6.4.	Arginine	148-156	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	266-271
24743655-7	2014	Several novel RNAi suppressors of Tp53 were identified, one of which, PRDM1beta (BLIMP-1), was confirmed to be an Arg-specific transcript.	Arginine	114-117	tumor protein p53	Homo sapiens	34-38
24743655-7	2014	Several novel RNAi suppressors of Tp53 were identified, one of which, PRDM1beta (BLIMP-1), was confirmed to be an Arg-specific transcript.	Arginine	114-117	PR/SET domain 1	Homo sapiens	81-88
24860166-6	2014	Brd4 PID shows a surprising sequence motif similarity to the trans-activating Tat protein from HIV-1, which includes a core RxL motif, a polybasic cluster known as arginine-rich motif, and a C-terminal leucine motif.	Arginine	164-172	bromodomain containing 4	Homo sapiens	0-4
24691905-5	2014	By employing homologous recombination, we introduced various combinations of missense mutations (lysine to arginine) into eight acetylation sites of the endogenous p53 gene in human embryonic stem cells (hESCs).	Arginine	107-115	tumor protein p53	Homo sapiens	164-167
24802752-8	2014	Using molecular modeling, we hypothesized that Arg(28) might contribute to IL-6R/CNTFR plasticity of CNTF.	Arginine	47-50	interleukin 6 receptor	Homo sapiens	75-80
24474455-8	2014	The Arg72Pro-p53 polymorphism showed for the genotypes Arg/Pro and Pro/Pro, and for the Pro allele, a significant association only to the risk for CIN (p&lt;0.03).	Arginine	4-7	tumor protein p53	Homo sapiens	13-16
24657947-0	2014	Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment.	Arginine	39-47	vascular endothelial growth factor A	Homo sapiens	104-108
24530559-6	2014	Arg-UPEA/GMA-chitosan hybrid hydrogels activated both TNF-alpha and NO production by RAW 264.7 macrophages, and the arginase activity was also elevated.	Arginine	0-3	tumor necrosis factor	Homo sapiens	54-63
24915079-1	2014	Transportin SR2 (TRN-SR2) is a beta-type karyopherin responsible for the nuclear import of specific cargoes, including serine/arginine-rich splicing factors.	Arginine	126-134	transportin 3	Homo sapiens	0-15
24915079-1	2014	Transportin SR2 (TRN-SR2) is a beta-type karyopherin responsible for the nuclear import of specific cargoes, including serine/arginine-rich splicing factors.	Arginine	126-134	transportin 3	Homo sapiens	17-24
24710610-2	2014	A common polymorphism of the encoding TP53 gene (codon 72, Pro &gt; Arg, rs1042522) is associated with susceptibility to virus-related and other cancers.	Arginine	68-71	tumor protein p53	Homo sapiens	38-42
24710610-5	2014	The allele frequency of TP53 codon 72 Arg was 0.30 among 314 Ghanaian primiparae and 0.31 among 545 Rwandan children, respectively, and it was not associated with infection prevalence or parasite density.	Arginine	38-41	tumor protein p53	Homo sapiens	24-28
24828792-7	2014	RESULTS: A variant (cG1553A) was found in a single patient in the GRIN2A gene, causing an arginine to histidine change at site 518, a predicted glutamate binding site.	Arginine	90-98	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	66-72
24573419-5	2014	We also show that like human apoE, recombinant NapoE is able to inhibit LDL oxidation, and it is the N-terminal domain of NapoE with lysine or arginine residues that plays a key role in inhibition of LDL oxidation.	Arginine	143-151	apolipoprotein E	Homo sapiens	29-33
24322605-7	2014	Additionally, in the chronic phase, GHRH-arginine test was used for the diagnosis of growth hormone (GH) deficiency.	Arginine	41-49	growth hormone releasing hormone	Homo sapiens	36-40
24771854-4	2014	Therefore, we hypothesized that PAD-mediated citrullination of the arginine residues within LL-37 will abrogate its immunomodulatory functions.	Arginine	67-75	cathelicidin antimicrobial peptide	Homo sapiens	92-97
23775820-8	2014	Also, the simulations revealed different conformations of fibronectin on each scaffold type after adsorption, with the arginine-glycine-aspartic acid sequence appearing most accessible on the aminated scaffolds.	Arginine	119-127	fibronectin 1	Homo sapiens	58-69
24814006-5	2014	Lysozyme was modified specifically at Arginine residues by the action of phenylglyoxal, and was extensively studied in this work to better characterize the mixed-mode interactions of HEA HyperCel  and PPA HyperCel  chromatographic supports.	Arginine	38-46	lysozyme	Homo sapiens	0-8
24670969-7	2014	Finally, arginine supplementation reduced (P &lt; 0.05) expression of the proteins for NF-kappaB, MAPK, and PI3K-Akt signaling pathways but activated (P &lt; 0.05) p38 and c-Jun N-terminal protein kinase in the jejunum and the ileum, respectively.	Arginine	9-17	thymoma viral proto-oncogene 1	Mus musculus	113-116
24670969-8	2014	Collectively, dietary arginine supplementation of mice changes the intestinal microbiota, contributing to the activation of intestinal innate immunity through NF-kappaB, MAPK, and PI3K-phosphorylated Akt signaling pathways.	Arginine	22-30	thymoma viral proto-oncogene 1	Mus musculus	200-203
24625390-6	2014	In the event of pairwise combinations of the single nucleotide polymorphisms, a risk elevation was shown for MDM2 GG homozygotes/p53 wild-type Arg in hereditary melanoma (P=0.01).	Arginine	143-146	tumor protein p53	Homo sapiens	129-132
24750273-5	2014	The Elp1 carboxy-terminal domain contains a highly conserved arginine/lysine-rich region that resembles a nuclear localization sequence (NLS).	Arginine	61-69	Elongator subunit IKI3	Saccharomyces cerevisiae S288C	4-8
24837102-5	2014	This amplification required arginine residues in the ICOSL cytoplasmic tail that recruited the adaptor protein RACK1 and the kinases PKC and JNK leading to PKC, MAPK, and NF-kappaB activation.	Arginine	28-36	mitogen-activated protein kinase 8	Homo sapiens	141-144
24753409-6	2014	Mutation of this site to arginine abolishes Rad1 sumoylation and impairs Rad1-mediated repair at high doses of DNA damage, but sustains the repair of a single double-stranded break.	Arginine	25-33	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	44-48
24753409-6	2014	Mutation of this site to arginine abolishes Rad1 sumoylation and impairs Rad1-mediated repair at high doses of DNA damage, but sustains the repair of a single double-stranded break.	Arginine	25-33	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	73-77
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Arginine	41-49	peroxisomal biogenesis factor 10	Homo sapiens	84-90
24753255-6	2014	Furthermore, NF-kappaB p65, a critical driver of TNF-alpha-mediated CXCL10 induction, was determined to be methylated at arginine residues.	Arginine	121-129	tumor necrosis factor	Homo sapiens	49-58
24657665-3	2014	The G to T transversion at the third position of codon 249 (AGG) of the TP53 gene, substituting arginine to serine, is the most common aflatoxin-induced mutation linked to HCC.	Arginine	96-104	tumor protein p53	Homo sapiens	72-76
24843801-7	2014	There is a statistically significant association between p53 codon 72 polymorphism and allergic asthma: Arg/Arg genotype is more represented in asthmatic patients than in controls (P=0.018).	Arginine	104-107	tumor protein p53	Homo sapiens	57-60
24843801-7	2014	There is a statistically significant association between p53 codon 72 polymorphism and allergic asthma: Arg/Arg genotype is more represented in asthmatic patients than in controls (P=0.018).	Arginine	108-111	tumor protein p53	Homo sapiens	57-60
24600012-3	2014	The type II transmembrane serine protease TMPRSS2 is expressed in the respiratory tract and is capable of activating a variety of respiratory viruses, including low-pathogenic (LP) IAVs possessing a single arginine residue at the cleavage site.	Arginine	206-214	transmembrane serine protease 2	Homo sapiens	42-49
24573245-3	2014	We have found that the best proteinogenic amino acid recognized by LTA4H is arginine.	Arginine	76-84	leukotriene A4 hydrolase	Homo sapiens	67-72
24268865-0	2014	Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection.	Arginine	0-8	albumin	Homo sapiens	49-62
24268865-5	2014	Fourier transform infrared spectroscopy showed that BSA is in its native state even in the presence of ArgHCl, LysHCl, and NaCl at high protein concentrations.	Arginine	103-109	albumin	Homo sapiens	52-55
24676941-0	2014	Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.	Arginine	22-30	ADP-ribosyltransferase 1	Mus musculus	40-64
24705350-1	2014	This work is based on previous evidence showing that chemotactic sequence of the urokinase receptor (uPAR(88-92)) drives angiogenesis in vitro and in vivo in a protease-independent manner, and that the peptide Ac-Arg-Glu-Arg-Phe-NH(2) (RERF) prevents both uPAR(88-92)- and VEGF-induced angiogenesis.	Arginine	213-216	plasminogen activator, urokinase receptor	Mus musculus	101-105
24705350-1	2014	This work is based on previous evidence showing that chemotactic sequence of the urokinase receptor (uPAR(88-92)) drives angiogenesis in vitro and in vivo in a protease-independent manner, and that the peptide Ac-Arg-Glu-Arg-Phe-NH(2) (RERF) prevents both uPAR(88-92)- and VEGF-induced angiogenesis.	Arginine	213-216	plasminogen activator, urokinase receptor	Mus musculus	256-260
24650257-6	2014	Results from protein-ligand docking calculations predict S2" subsite residues Arg 102 and Arg 110 of NEP participate in specific interactions with Abeta.	Arginine	78-81	membrane metalloendopeptidase	Homo sapiens	101-104
24615730-13	2014	Our study implicates a critical role for the T/PRL-stimulated CPD-Arg-NO pathway in pCa progression, and suggests that AR+PRLR inhibition is a more effective treatment for pCa.	Arginine	66-69	prolactin	Homo sapiens	47-50
24650257-6	2014	Results from protein-ligand docking calculations predict S2" subsite residues Arg 102 and Arg 110 of NEP participate in specific interactions with Abeta.	Arginine	90-93	membrane metalloendopeptidase	Homo sapiens	101-104
24642397-1	2014	This study highlights the ability of arginine to elute bovine serum albumin (BSA) and a monoclonal antibody against interleukin-8 (mAb-IL8) from Capto MMC, which is a multimodal cation exchanger.	Arginine	37-45	albumin	Homo sapiens	62-75
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	casein beta	Bos taurus	48-52
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	casein kappa	Bos taurus	54-58
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	ribosomal protein S6 kinase B1	Bos taurus	82-85
24283776-1	2014	BACKGROUND AND PURPOSE: It has been proposed that arginine residues lining the intracellular portals of the homomeric 5-HT3 A receptor cause electrostatic repulsion of cation flow, accounting for a single-channel conductance substantially lower than that of the 5-HT3 AB heteromer.	Arginine	50-58	5-hydroxytryptamine receptor 3A	Homo sapiens	118-125
24710345-6	2014	RESULTS: A combination of WES and Sanger sequencing revealed the genetic defect to be a novel compound heterozygous genotype in PKHD1, including the missense mutation c.2507 T&gt;C, predicted to cause a valine to alanine substitution at codon 836 (c.2507T&gt;C, p.Val836Ala), and the nonsense mutation c.2341C&gt;T, which is predicted to result in an arginine to stop codon at codon 781 (c.2341C&gt;T, p.Arg781*).	Arginine	351-359	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	128-133
24384472-8	2014	Through this study, we have provided the first evidence on the pivotal role of arginine 213 that determines the p53 mediated functions of p21 in human cancer cells.	Arginine	79-87	tumor protein p53	Homo sapiens	112-115
24747975-0	2014	Evaluating the association between p53 codon 72 Arg&gt;pro polymorphism and risk of ovary cancer: a meta-analysis.	Arginine	48-51	tumor protein p53	Homo sapiens	35-38
24747975-3	2014	Therefore, we performed this meta-analysis to investigate the relation between p53 codon 72 Arg&gt;Pro polymorphism and overall OC susceptibility.	Arginine	92-95	tumor protein p53	Homo sapiens	79-82
24747975-4	2014	METHODS: We searched all eligible published studies based on the association between codon 72 of the p53 Arg&gt;Pro polymorphism and risk of OC.	Arginine	105-108	tumor protein p53	Homo sapiens	101-104
24747975-10	2014	CONCLUSIONS: This meta-analysis suggested that codon 72 of the p53 Arg&gt;Pro polymorphism may not significantly contribute in ovary cancer susceptibility.	Arginine	67-70	tumor protein p53	Homo sapiens	63-66
24574257-2	2014	In this study, N(5) -(1-imino-2-chloroethyl)-L-ornithine (Cl-NIO) is shown to be a potent time- and concentration-dependent inhibitor of purified human DDAH-1 (KI =1.3+-0.6 muM; kinact =0.34+-0.07 min(-1) ), with &gt;500-fold selectivity against two arginine-handling enzymes in the same pathway.	Arginine	250-258	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	152-158
24495993-7	2014	Intake of other AA like alanine and/or arginine was also inversely associated with serum TC, LDL-c and Apo B/Apo A1 ratio only in girls.	Arginine	39-47	apolipoprotein B	Homo sapiens	103-108
24472006-13	2014	These studies show that L-Arg blunts AngII-mediated vascular contraction by an endothelial- and nitric oxide synthase-dependent mechanism involving cellular uptake of L-Arg.	Arginine	24-29	angiotensinogen	Rattus norvegicus	37-42
24472006-13	2014	These studies show that L-Arg blunts AngII-mediated vascular contraction by an endothelial- and nitric oxide synthase-dependent mechanism involving cellular uptake of L-Arg.	Arginine	167-172	angiotensinogen	Rattus norvegicus	37-42
24472006-0	2014	Exogenous L-arginine attenuates the effects of angiotensin II on renal hemodynamics and the pressure natriuresis-diuresis relationship.	Arginine	10-20	angiotensinogen	Rattus norvegicus	47-61
24472006-1	2014	Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats.	Arginine	28-38	angiotensinogen	Rattus norvegicus	58-72
24472006-1	2014	Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats.	Arginine	28-38	angiotensinogen	Rattus norvegicus	74-79
24472006-1	2014	Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats.	Arginine	40-45	angiotensinogen	Rattus norvegicus	58-72
24472006-1	2014	Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats.	Arginine	40-45	angiotensinogen	Rattus norvegicus	74-79
24472006-7	2014	Supplementation of L-Arg reversed the vasoconstrictor effects of AngII and restored pressure-dependent diuresis to levels not significantly different from control rats.	Arginine	19-24	angiotensinogen	Rattus norvegicus	65-70
24472006-9	2014	Contraction to 10(-7) mol/L AngII was blunted by 75 +- 3% with 10(-4) mol/L L-Arg.	Arginine	76-81	angiotensinogen	Rattus norvegicus	28-33
24472006-10	2014	The influence of L-Arg to blunt AngII-mediated contraction was eliminated by endothelial denudation or incubation with nitric oxide synthase inhibitors.	Arginine	17-22	angiotensinogen	Rattus norvegicus	32-37
24100601-3	2014	The objective of this study was to determine the influence of long-term L-arginine supplementation on the expression of the three isoforms of nitric oxide synthase (NOS) and VIP in small intestine of rats acclimated to room temperature or cold.	Arginine	72-82	vasoactive intestinal peptide	Rattus norvegicus	174-177
24100601-6	2014	RESULTS: Long-term dietary L-arginine supplementation increases VIP and NOSs immunoexpression at room temperature while at cold increases the endothelial NOS, inducible NOS and VIP but decrease neuronal NOS in rat small intestine.	Arginine	27-37	vasoactive intestinal peptide	Rattus norvegicus	64-67
24100601-6	2014	RESULTS: Long-term dietary L-arginine supplementation increases VIP and NOSs immunoexpression at room temperature while at cold increases the endothelial NOS, inducible NOS and VIP but decrease neuronal NOS in rat small intestine.	Arginine	27-37	vasoactive intestinal peptide	Rattus norvegicus	177-180
24100601-7	2014	CONCLUSION: Our results demonstrate that long-term dietary L-arginine supplementation modulates NOSs and VIP immunoexpression in rat small intestine with respect to ambient temperature, pointing out the eNOS as a predominant NOS isoform with an immunoexpression pattern similar to VIP.	Arginine	59-69	vasoactive intestinal peptide	Rattus norvegicus	105-108
24100601-7	2014	CONCLUSION: Our results demonstrate that long-term dietary L-arginine supplementation modulates NOSs and VIP immunoexpression in rat small intestine with respect to ambient temperature, pointing out the eNOS as a predominant NOS isoform with an immunoexpression pattern similar to VIP.	Arginine	59-69	vasoactive intestinal peptide	Rattus norvegicus	281-284
24417973-7	2014	Interestingly, treatment with L-Leucine or L-Arginine, amino acids that augment mRNA translation via mTOR pathway, rescued the morphological defects and resulted in a substantial recovery of erythroid cells.	Arginine	43-53	mechanistic target of rapamycin kinase	Danio rerio	101-105
24495993-7	2014	Intake of other AA like alanine and/or arginine was also inversely associated with serum TC, LDL-c and Apo B/Apo A1 ratio only in girls.	Arginine	39-47	apolipoprotein A1	Homo sapiens	109-115
26005655-3	2014	Although some studies have indicated an association between the TP53 Arg/Arg variant and an increased risk for prostate cancer, other studies have shown a positive correlation between the TP53 Pro/Pro genotype instead.	Arginine	69-72	tumor protein p53	Homo sapiens	64-68
26005655-3	2014	Although some studies have indicated an association between the TP53 Arg/Arg variant and an increased risk for prostate cancer, other studies have shown a positive correlation between the TP53 Pro/Pro genotype instead.	Arginine	73-76	tumor protein p53	Homo sapiens	64-68
24210052-7	2014	A novel metabolism of proline and arginine catalyzed by N-acetyltransferase Mpr1 in the mitochondria eventually leads to synthesis of nitric oxide, which confers oxidative stress tolerance on yeast cells.	Arginine	34-42	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	76-80
24451227-1	2014	c.224G&gt;A, p.Arg75Gln (R75Q) presumably leads to an amino-acid change from arginine to glutamine in the membrane-spanning domain of the CFTR protein.	Arginine	77-85	CF transmembrane conductance regulator	Homo sapiens	138-142
24225560-0	2014	Oral L-arginine before resistance exercise blunts growth hormone in strength trained males.	Arginine	5-15	growth hormone 1	Homo sapiens	50-64
24225560-1	2014	Acute resistance exercise and L-arginine have both been shown to independently elevate plasma growth hormone (GH) concentrations; however, their combined effect is controversial.	Arginine	30-40	growth hormone 1	Homo sapiens	94-108
24225560-1	2014	Acute resistance exercise and L-arginine have both been shown to independently elevate plasma growth hormone (GH) concentrations; however, their combined effect is controversial.	Arginine	30-40	growth hormone 1	Homo sapiens	110-112
24225560-8	2014	GH-inhibiting hormone was significantly lower in the ARG condition.	Arginine	53-56	growth hormone 1	Homo sapiens	0-2
24225560-9	2014	However, integrated area under the curve for GH was blunted in the ARG condition (L-arginine = 288.4 +- 368.7 vs. placebo = 487.9+- 482.0 min ng mL1, p &lt; .05).	Arginine	67-70	growth hormone 1	Homo sapiens	45-47
24225560-9	2014	However, integrated area under the curve for GH was blunted in the ARG condition (L-arginine = 288.4 +- 368.7 vs. placebo = 487.9+- 482.0 min ng mL1, p &lt; .05).	Arginine	82-92	growth hormone 1	Homo sapiens	45-47
24225560-10	2014	L-arginine ingested before resistance exercise significantly elevated plasma L-arginine concentration but attenuated plasma GH in strength trained individuals despite a lower GHIH.	Arginine	0-10	growth hormone 1	Homo sapiens	124-126
24022566-0	2014	Oral L-arginine modulates blood lactate and interleukin-6 after exercise in HIV-infected men.	Arginine	5-15	interleukin 6	Homo sapiens	44-57
24022566-9	2014	L-arg administration had no significant effect on TNF-alpha or IL-10 concentrations, but increased post-exercise IL-6 (placebo=19+-3pg.mL-1; L-arg=63+-8 pg.mL-1; p&lt;0.05).	Arginine	0-5	interleukin 6	Homo sapiens	113-117
24022566-10	2014	In HIV-1 infected men, acute administration of L-arg reduces post-exercise blood LAC and increases IL-6 levels, suggesting the activation of the L-arg-NO pathway, with possible anti-inflammatory consequences.	Arginine	47-52	interleukin 6	Homo sapiens	99-103
24726125-7	2014	RESULTS: All affected individuals carry a novel heterozygous nonsense mutation in the EDNRB gene (c.C397T,p.R133X,refNM_000115), changing an arginine at position 133 into a premature stop codon.	Arginine	141-149	endothelin receptor type B	Homo sapiens	86-91
24615009-7	2014	Notably, patients with TP53 mutation and the Pro72 allele experienced a 23.7-fold increase in hazard ratio (95% CI 3.38-165.9; P = 0.001) for OS compared with patients with wild-type p53 and those with the Arg/Arg genotype.	Arginine	206-209	tumor protein p53	Homo sapiens	23-27
24453360-6	2014	We found that a specific arginine residue and several aromatic residues, as well as the zinc-coordinating cysteines in the C-terminal domain, are necessary for mA3 packaging; a structural model of this domain suggests that these residues line a potential nucleic acid-binding interface.	Arginine	25-33	olfactory receptor family 2 subfamily B member 4	Mus musculus	160-163
24615009-7	2014	Notably, patients with TP53 mutation and the Pro72 allele experienced a 23.7-fold increase in hazard ratio (95% CI 3.38-165.9; P = 0.001) for OS compared with patients with wild-type p53 and those with the Arg/Arg genotype.	Arginine	210-213	tumor protein p53	Homo sapiens	23-27
24510189-8	2014	They also revealed a crucial role for a conserved asparagine-arginine containing loop (the NR-loop) in the DCP1 EVH1 domain in DCP2 activation.	Arginine	61-69	decapping mRNA 1B	Homo sapiens	107-111
24678288-1	2014	BACKGROUND: Nutritional supplements based on the amino acid L-arginine have been hypothesized to improve exercise performance by increasing levels of insulin and growth hormone (GH).	Arginine	60-70	insulin	Homo sapiens	150-157
24326769-0	2014	The association between polymorphism of P53 Codon72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3,704 cases.	Arginine	52-55	tumor protein p53	Homo sapiens	40-43
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	33-41	tumor protein p53	Homo sapiens	16-19
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	33-41	tumor protein p53	Homo sapiens	104-107
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	43-46	tumor protein p53	Homo sapiens	16-19
24326769-2	2014	Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	43-46	tumor protein p53	Homo sapiens	104-107
24326769-3	2014	It has been suggested that p53 codon72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC).	Arginine	39-42	tumor protein p53	Homo sapiens	27-30
24326769-10	2014	This meta-analysis suggests that p53 codon72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus.	Arginine	45-48	tumor protein p53	Homo sapiens	33-36
26104420-1	2014	OBJECTIVE: To evaluate the l-arginine/NO system and its role in insulin signaling and endothelial function during the pregnancy of women of different BMI categories.	Arginine	27-37	insulin	Homo sapiens	64-71
26104420-6	2014	In the 1st trimester, the insulin levels were significantly reduced in both groups after l-Arg infusion.	Arginine	89-94	insulin	Homo sapiens	26-33
24509845-8	2014	We further report that the Sgf11 ZnF, but not the Sgf73 ZnF, binds to nucleosomal DNA with a binding interface composed of arginine residues located within the ZnF alpha-helix.	Arginine	123-131	SAGA histone acetyltransferase complex subunit SGF11	Saccharomyces cerevisiae S288C	27-32
24678288-1	2014	BACKGROUND: Nutritional supplements based on the amino acid L-arginine have been hypothesized to improve exercise performance by increasing levels of insulin and growth hormone (GH).	Arginine	60-70	growth hormone 1	Homo sapiens	162-176
24678288-1	2014	BACKGROUND: Nutritional supplements based on the amino acid L-arginine have been hypothesized to improve exercise performance by increasing levels of insulin and growth hormone (GH).	Arginine	60-70	growth hormone 1	Homo sapiens	178-180
24678288-3	2014	OBJECTIVE: The aim of the study was to evaluate the effect of L-arginine supplementation on serum insulin, GH, Growth Factor Insulin-like (IGF-1), and cortisol in response to exercise.	Arginine	62-72	insulin	Homo sapiens	98-105
24678288-3	2014	OBJECTIVE: The aim of the study was to evaluate the effect of L-arginine supplementation on serum insulin, GH, Growth Factor Insulin-like (IGF-1), and cortisol in response to exercise.	Arginine	62-72	growth hormone 1	Homo sapiens	107-109
24678288-3	2014	OBJECTIVE: The aim of the study was to evaluate the effect of L-arginine supplementation on serum insulin, GH, Growth Factor Insulin-like (IGF-1), and cortisol in response to exercise.	Arginine	62-72	insulin	Homo sapiens	125-132
24678288-3	2014	OBJECTIVE: The aim of the study was to evaluate the effect of L-arginine supplementation on serum insulin, GH, Growth Factor Insulin-like (IGF-1), and cortisol in response to exercise.	Arginine	62-72	insulin like growth factor 1	Homo sapiens	139-144
24655927-3	2014	METHODS: We examined the immunohistochemical expression of two markers of microglial phenotype, the arginine-metabolizing enzymes inducible nitric oxide synthase (iNOS) and arginase1 (Arg1), in the spinal cord of a mouse model carrying an ALS-linked mutant human superoxide dismutase transgene (SOD1(G93A)) and in non-transgenic wild-type (WT) mice.	Arginine	100-108	nitric oxide synthase 2, inducible	Mus musculus	130-161
24435975-7	2014	However, in a multivariate analysis adjusted for alcohol consumption, smoking, ethnicity, and number of pregnancies, the interaction between the genotypes TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) showed to be associated to RPL, increasing the risk for this condition (OR = 2.58, 95% CI: 1.31-5.07, p = 0.006).	Arginine	160-163	tumor protein p53	Homo sapiens	155-159
24643009-6	2014	The gating mechanism in the inward-facing state of EAAT3 is found to be different from that of GltPh, which is traced to the relocation of an arginine residue from the HP1 segment in GltPh to the TM8 segment in EAAT3.	Arginine	142-150	solute carrier family 1 member 1	Homo sapiens	51-56
24643009-6	2014	The gating mechanism in the inward-facing state of EAAT3 is found to be different from that of GltPh, which is traced to the relocation of an arginine residue from the HP1 segment in GltPh to the TM8 segment in EAAT3.	Arginine	142-150	solute carrier family 1 member 1	Homo sapiens	211-216
24412336-4	2014	Some amino acids namely arginine, glycine and histidine showed good retention of catalase functionality after spray drying and subsequent storage stress.	Arginine	24-32	catalase	Homo sapiens	81-89
24224890-2	2014	ASS is the rate-limiting enzyme in the urea cycle and along with nitric oxide synthase 2 (NOS2), it endows cells with the l-citrulline/NO  salvage pathway to continuously supply l-arginine from l-citrulline for sustained NO  generation.	Arginine	178-188	nitric oxide synthase 2, inducible	Mus musculus	65-88
24224890-2	2014	ASS is the rate-limiting enzyme in the urea cycle and along with nitric oxide synthase 2 (NOS2), it endows cells with the l-citrulline/NO  salvage pathway to continuously supply l-arginine from l-citrulline for sustained NO  generation.	Arginine	178-188	nitric oxide synthase 2, inducible	Mus musculus	90-94
24354792-3	2014	A key N-terminal arginine in each of PARs 1 to 4 has been singled out as a target for cleavage by thrombin (PARs 1, 3 and 4), trypsin (PARs 2 and 4) or other proteases to unmask the TL that activates signalling via Gq , Gi or G12 /13 .	Arginine	17-25	coagulation factor II, thrombin	Homo sapiens	98-106
24354792-3	2014	A key N-terminal arginine in each of PARs 1 to 4 has been singled out as a target for cleavage by thrombin (PARs 1, 3 and 4), trypsin (PARs 2 and 4) or other proteases to unmask the TL that activates signalling via Gq , Gi or G12 /13 .	Arginine	17-25	coagulation factor II thrombin receptor	Homo sapiens	108-123
24651445-0	2014	L-arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway.	Arginine	0-10	AKT serine/threonine kinase 1	Homo sapiens	82-85
24651445-4	2014	We also sought to elucidate the signaling pathways involved in mediating the effects of arginine on fibroblasts by evaluation of extracellular signal-related kinase (ERK) 1/2 activation, which is important for cell growth, survival, and differentiation.	Arginine	88-96	mitogen-activated protein kinase 3	Homo sapiens	129-174
24651445-6	2014	In vitro kinase assays demonstrated that arginine supplementation activated ERK1/2, Akt, PKA and its downstream target, cAMP response element binding protein (CREB).	Arginine	41-49	mitogen-activated protein kinase 3	Homo sapiens	76-82
24651445-6	2014	In vitro kinase assays demonstrated that arginine supplementation activated ERK1/2, Akt, PKA and its downstream target, cAMP response element binding protein (CREB).	Arginine	41-49	AKT serine/threonine kinase 1	Homo sapiens	84-87
24651445-8	2014	The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival.	Arginine	109-117	AKT serine/threonine kinase 1	Homo sapiens	84-87
24591642-7	2014	This interaction site, which we have named the arginine site, allowed us to define unique PP1 binding motifs, which advances our ability to predict how more than a quarter of the known PP1 regulators bind PP1.	Arginine	47-55	inorganic pyrophosphatase 1	Homo sapiens	90-93
24591642-7	2014	This interaction site, which we have named the arginine site, allowed us to define unique PP1 binding motifs, which advances our ability to predict how more than a quarter of the known PP1 regulators bind PP1.	Arginine	47-55	inorganic pyrophosphatase 1	Homo sapiens	185-188
24591642-7	2014	This interaction site, which we have named the arginine site, allowed us to define unique PP1 binding motifs, which advances our ability to predict how more than a quarter of the known PP1 regulators bind PP1.	Arginine	47-55	inorganic pyrophosphatase 1	Homo sapiens	185-188
24453002-3	2014	PRMT5 silences the transcription of regulatory genes by catalyzing symmetric dimethylation of arginine residues on histone tails.	Arginine	94-102	protein arginine methyltransferase 5	Homo sapiens	0-5
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Arginine	129-137	amino acid permease GAP1	Saccharomyces cerevisiae S288C	46-50
26417255-7	2014	According to our data, substitution of the Arginine residue by the uncharged state of this residue induces some reversible structural alterations in the intrinsically flexible loop area including residues 167-171 of PrP.	Arginine	43-51	prion protein	Homo sapiens	216-219
24442486-9	2014	The upregulation of ARG II was accompanied by a downregulation of eNOS but an induction of iNOS in HCMV-infected endothelial cells.	Arginine	20-23	nitric oxide synthase 2	Homo sapiens	91-95
24213248-4	2014	Arg-9, penetratin, and TAT-D displayed consistent and high level neuroprotective activity in both the glutamic acid (IC50: 0.78, 3.4, 13.9 muM) and kainic acid (IC50: 0.81, 2.0, 6.2 muM) injury models, while Pep-1 was ineffective.	Arginine	0-3	latexin	Homo sapiens	139-142
24213248-4	2014	Arg-9, penetratin, and TAT-D displayed consistent and high level neuroprotective activity in both the glutamic acid (IC50: 0.78, 3.4, 13.9 muM) and kainic acid (IC50: 0.81, 2.0, 6.2 muM) injury models, while Pep-1 was ineffective.	Arginine	0-3	latexin	Homo sapiens	182-185
24188174-6	2014	Further, we demonstrate the ability of fibronectin and other plasma proteins to act through cell adhesion via the ubiquitous arginine-glycine-aspartic (RGD) motif to drive monocyte-to-DC differentiation, with high-density RGD substrates supporting 54 1 +- 5 8% differentiation via alphaVbeta3 and alpha5beta1integrin signalling.	Arginine	125-133	fibronectin 1	Homo sapiens	39-50
24451260-4	2014	Novel evidence links hypoxia and HIF-1 to arginine methylation, an important protein modification.	Arginine	42-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-38
24435975-7	2014	However, in a multivariate analysis adjusted for alcohol consumption, smoking, ethnicity, and number of pregnancies, the interaction between the genotypes TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) showed to be associated to RPL, increasing the risk for this condition (OR = 2.58, 95% CI: 1.31-5.07, p = 0.006).	Arginine	164-167	tumor protein p53	Homo sapiens	155-159
24435975-8	2014	In conclusion, our study indicates that the combination of TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) genotypes may be a risk factor for RPL.	Arginine	64-67	tumor protein p53	Homo sapiens	59-63
24435975-8	2014	In conclusion, our study indicates that the combination of TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) genotypes may be a risk factor for RPL.	Arginine	68-71	tumor protein p53	Homo sapiens	59-63
24375409-7	2014	Asn(7.32) is affected by modifications on position Arg(33) of hPP, suggesting a hydrogen bond between these two residues.	Arginine	51-54	familial progressive hyperpigmentation 1	Homo sapiens	62-65
24366026-2	2014	The polymorphism in the p53 72nd codon involves a proline to arginine substitution, leading to changes in gene transcription activity, interaction with other proteins and modulation of apoptosis.	Arginine	61-69	tumor protein p53	Homo sapiens	24-27
24303925-7	2014	Our research indicated that blue light irradiation caused cleavage throughout the A2E molecule closest to the pyridinium ring, and attached to the fibronectin peptide preferentially at lysine and arginine residues.	Arginine	196-204	fibronectin 1	Homo sapiens	147-158
24320160-1	2014	Protein arginine N-methyltransferase 3 (PRMT3) belongs to the family of type I PRMTs and harbors the activity to use S-adenosyl-l-methionine (SAM) as a methyl-donor cofactor for protein arginine labeling.	Arginine	8-16	protein arginine methyltransferase 3	Homo sapiens	40-45
24488111-7	2014	Mutation of a pair of conserved arginine residues in the Dicer-2 PAZ domain blocked cleavage of short, but not long, dsRNA.	Arginine	32-40	Dicer-2	Drosophila melanogaster	57-64
24468086-6	2014	gammaGlu47 may also form salt bridges with two conserved arginines (Arg75 and Arg184 in Cx26), which are considered important in stabilizing the structure of the extracellular region.	Arginine	57-66	gap junction protein beta 2	Homo sapiens	88-92
24587255-8	2014	We also demonstrated that cell lines bearing Pro/Pro homozygosity in codon72 of p53 exon4, which is important for NF-kappaB binding to p53, are more resistant to 5-FU than those with Arg/Arg homozygosity.	Arginine	183-186	tumor protein p53	Homo sapiens	80-83
24587255-8	2014	We also demonstrated that cell lines bearing Pro/Pro homozygosity in codon72 of p53 exon4, which is important for NF-kappaB binding to p53, are more resistant to 5-FU than those with Arg/Arg homozygosity.	Arginine	187-190	tumor protein p53	Homo sapiens	80-83
24570487-4	2014	In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes.	Arginine	62-70	cAMP responsive element binding protein 1	Mus musculus	135-139
24449914-4	2014	A constellation of charged residues on and around the arginine-rich helix of Tnpo3 HEAT repeat 15 engage the phosphorylated RS domain and are critical for the recognition and nuclear import of ASF/SF2.	Arginine	54-62	transportin 3	Homo sapiens	77-82
24611012-2	2014	TAT peptide (TATp), is an amphipathic, arginine-rich, cationic peptide that promotes penetration and translocation of various molecules and nanoparticles into cells.	Arginine	39-47	tyrosine aminotransferase	Bos taurus	0-3
24611012-2	2014	TAT peptide (TATp), is an amphipathic, arginine-rich, cationic peptide that promotes penetration and translocation of various molecules and nanoparticles into cells.	Arginine	39-47	tyrosine aminotransferase	Bos taurus	13-17
24285724-12	2014	Taken together, our findings argue that arginine deprivation combined with antifolates warrants clinical investigation in ASS1-negative urothelial and related cancers, using FLT-PET as an early surrogate marker of response.	Arginine	40-48	fms related receptor tyrosine kinase 1	Homo sapiens	174-177
24334254-8	2014	This is clearly illustrated by the differences in copy numbers not only in gene PUT1, the main player in the assimilation of proline as a nitrogen source, but also in CAR2, involved in arginine catabolism.	Arginine	185-193	proline dehydrogenase	Saccharomyces cerevisiae S288C	80-84
24498420-0	2014	JMJD6 regulates ERalpha methylation on arginine.	Arginine	39-47	estrogen receptor 1	Homo sapiens	16-23
24498420-1	2014	ERalpha functions are tightly controlled by numerous post-translational modifications including arginine methylation, which is required to mediate the extranuclear functions of the receptor.	Arginine	96-104	estrogen receptor 1	Homo sapiens	0-7
24186145-8	2014	RESULTS: The plasma arginine level was significantly inversely correlated with plasma levels of total and free estradiol and IGF-1 after adjusting for age, body mass index, and phase of the menstrual cycle.	Arginine	20-28	insulin like growth factor 1	Homo sapiens	125-130
24186145-11	2014	CONCLUSIONS: Plasma levels of some specific amino acids, such as arginine, leucine, tyrosine, and asparagine, were associated with the levels of sex hormones, SHBG, or IGF-1 in premenopausal women.	Arginine	65-73	sex hormone binding globulin	Homo sapiens	159-163
24186145-11	2014	CONCLUSIONS: Plasma levels of some specific amino acids, such as arginine, leucine, tyrosine, and asparagine, were associated with the levels of sex hormones, SHBG, or IGF-1 in premenopausal women.	Arginine	65-73	insulin like growth factor 1	Homo sapiens	168-173
24523531-6	2014	Furthermore, Coronin 6 forms a complex with AChRs and actin in a manner dependent on its C-terminal region and a conserved Arg(29) residue at the N terminus, both of which are critical for the cytoskeletal anchorage of AChRs.	Arginine	123-126	coronin 6	Mus musculus	13-22
24505477-6	2014	Dietary arginine or glutamine supplementation had significant (P&lt;0.05) influence on the clinical and biochemical parameters (T-SOD, IL-17 and TNF-alpha) in colitis model.	Arginine	8-16	tumor necrosis factor	Homo sapiens	145-154
24102471-6	2014	In addition, abnormal iNOS activity can up-regulate arginase activity, allowing it to compete with eNOS for L-arginine, thereby resulting in reduced NO bioavailability.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	22-26
24333670-7	2014	Serine/arginine-rich splicing factor 3 was a promising candidate for the serine/arginine-rich splicing factors responsible for the alternative splicing of p53 in response to caffeine treatment.	Arginine	7-15	tumor protein p53	Homo sapiens	155-158
23928928-10	2014	In addition, ETS-exposed carriers of the Arg allele of mEH exon 4 have a 2.1-fold increased risk of lung cancer (OR 2.1, P = 0.024).	Arginine	41-44	epoxide hydrolase 1, microsomal	Mus musculus	55-58
24284322-3	2014	Here we show that the EBNA1-nucleophosmin interaction is direct and requires the Gly-Arg-rich sequences that contribute to transactivation.	Arginine	85-88	EBNA-1	Human gammaherpesvirus 4	22-27
24551296-11	2014	), which is from an arginine codon (CGA) to a Glycine codon (GGA).	Arginine	20-28	chromogranin A	Homo sapiens	36-39
24138139-4	2014	The arginine-rich hPRM1 (47% arginine residues) generates high MRI contrast based on the chemical exchange saturation transfer (CEST) contrast mechanism.	Arginine	4-12	protamine 1	Homo sapiens	18-23
24138139-4	2014	The arginine-rich hPRM1 (47% arginine residues) generates high MRI contrast based on the chemical exchange saturation transfer (CEST) contrast mechanism.	Arginine	29-37	protamine 1	Homo sapiens	18-23
24333681-5	2014	This trypsin-like serine protease recognizes and cleaves viral polyproteins at the C-terminal end of an arginine residue, opening an avenue for the development of peptide-based antivirals.	Arginine	104-112	coagulation factor II, thrombin	Homo sapiens	18-33
24388985-11	2014	We conclude that the arginine residue at position 482 of the ABCG2 molecule is of major importance for the interaction of telmisartan with this ABC transporter.	Arginine	21-29	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-66
24388985-11	2014	We conclude that the arginine residue at position 482 of the ABCG2 molecule is of major importance for the interaction of telmisartan with this ABC transporter.	Arginine	21-29	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-159
24405844-8	2014	RESULTS: Direct sequencing of MIP in all affected members revealed a heterozygous nucleotide exchange c.337C&gt;T predicting an arginine to a stop codon exchange (p.R113X).	Arginine	128-136	major intrinsic protein of lens fiber	Homo sapiens	30-33
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Arginine	30-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
24275664-4	2014	In proTNF-alpha the Arg-Ser-Ser-Ser-Arg sequence is situated next to the previously established ADAM17 cleavage site.	Arginine	20-23	a disintegrin and metallopeptidase domain 17	Mus musculus	96-102
24275664-4	2014	In proTNF-alpha the Arg-Ser-Ser-Ser-Arg sequence is situated next to the previously established ADAM17 cleavage site.	Arginine	36-39	a disintegrin and metallopeptidase domain 17	Mus musculus	96-102
24275664-7	2014	Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of knock-in of the Arg-Ser-Ser-Arg sequence in mouse CD163 revealed a receptor shedding comparable with that of human CD163.	Arginine	108-111	CD163 antigen	Mus musculus	142-147
24454848-4	2014	Most (24 of 33) ApoE mutant proteins registered to date with Online Mendelian Inheritance in Man, such as ApoE2 and ApoE4, involve lysine and arginine mutations.	Arginine	142-150	apolipoprotein E	Homo sapiens	16-20
24454848-4	2014	Most (24 of 33) ApoE mutant proteins registered to date with Online Mendelian Inheritance in Man, such as ApoE2 and ApoE4, involve lysine and arginine mutations.	Arginine	142-150	apolipoprotein E	Homo sapiens	106-111
24454848-4	2014	Most (24 of 33) ApoE mutant proteins registered to date with Online Mendelian Inheritance in Man, such as ApoE2 and ApoE4, involve lysine and arginine mutations.	Arginine	142-150	apolipoprotein E	Homo sapiens	116-121
24275664-7	2014	Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of knock-in of the Arg-Ser-Ser-Arg sequence in mouse CD163 revealed a receptor shedding comparable with that of human CD163.	Arginine	120-123	CD163 antigen	Mus musculus	142-147
24803226-5	2014	In addition to Abeta peptides starting with an Asp at position 1, a variety of different N-truncated Abeta peptides have been identified starting with amino residue Ala-2, pyroglutamylated Glu-3, Phe-4, Arg-5, His-6, Asp-7, Ser-8, Gly-9, Tyr-10 and pyroglutamylated Glu-11.	Arginine	203-206	amyloid beta precursor protein	Homo sapiens	101-106
24293384-8	2014	At the same time, it was observed that L-arginine supplementation reduced the effect of the high-fat diet on insulin, TNF alpha, and TAS.	Arginine	39-49	tumor necrosis factor	Rattus norvegicus	118-127
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	46-49	tumor protein p53	Homo sapiens	16-19
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	46-49	tumor protein p53	Homo sapiens	41-44
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	46-49	tumor protein p53	Homo sapiens	41-44
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	16-19
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	41-44
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	41-44
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	16-19
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	41-44
25422197-11	2014	The analysis of p53 72 SNP revealed that p53 (Arg/Arg), (Pro /Arg) variant are higher (40.59% and 33.66%) as compared to p53 pro/pro variant (25.74%) in the healthy population.	Arginine	50-53	tumor protein p53	Homo sapiens	41-44
24761888-6	2014	Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively.	Arginine	112-115	tumor protein p53	Homo sapiens	54-57
24293384-12	2014	We concluded that the beneficial influence of L-arginine on insulin, TAS, and TNF alpha serum level is associated with changes in the iron and copper status in rats fed with a high-fat diet.	Arginine	46-56	tumor necrosis factor	Rattus norvegicus	78-87
24727379-7	2014	The structure establishes that the Tat-TAR recognition motif (TRM) in Cyclin T1 interacts with both Tat and AFF4, leading to the exposure of arginine side chains for binding to TAR RNA.	Arginine	141-149	cyclin T1	Homo sapiens	70-79
25215298-6	2014	Moreover, we conducted p53 mutation analysis and revealed a mutation at codon 273 which led to the replacement of arginine by histidine.	Arginine	114-122	tumor protein p53	Homo sapiens	23-26
24369116-4	2014	Our results show considerable differences in H43R compared to WT and W32F mutated SOD1, such as increasing distances between the critical residues results in open conformation at the active site, strong fluctuations in the important loops (Zinc and electrostatic loops) and weakening of important hydrogen bonds especially between N (His 43/Arg 43) and carbonyl oxygen (His 120) in agreement with the experimental report.	Arginine	341-344	superoxide dismutase 1	Homo sapiens	82-86
25121106-8	2014	Elimination of ADMA via overexpression of dimethylarginine dimethylaminohydrolase 2 (DDAH2) and L-arginine both blocks the effects of ADMA on the activation of Rho/ROCK and extra cellular signal-regulated kinase (ERK) in VSMCs.	Arginine	96-106	mitogen-activated protein kinase 1	Homo sapiens	173-211
25121106-8	2014	Elimination of ADMA via overexpression of dimethylarginine dimethylaminohydrolase 2 (DDAH2) and L-arginine both blocks the effects of ADMA on the activation of Rho/ROCK and extra cellular signal-regulated kinase (ERK) in VSMCs.	Arginine	96-106	mitogen-activated protein kinase 1	Homo sapiens	213-216
24180383-7	2014	In addition, eNOS associations with cationic amino acid transporter-1 (CAT-1), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and soluble guanylate cyclase (sGC) facilitate directed delivery of substrate (L-arginine) to eNOS and optimizing NO production and NO action on its target.	Arginine	223-233	nitric oxide synthase 3	Homo sapiens	13-17
25345515-8	2014	His-121, Ser-205, Arg-207 which were found to be playing crucial role in the binding of the selected compounds within the active site of caspase-3.	Arginine	18-21	caspase 3	Homo sapiens	137-146
24766729-7	2014	APOE4 protein, the isoform with arginines at residue 112 and 158, was found to form aggregates with more Abeta (P &lt; 0.001) and APOE (P &lt; 0.05) protein content in 10 mM FA than aggregates formed with either APOE3 or APOE2 protein.	Arginine	32-41	apolipoprotein E	Homo sapiens	0-5
24766729-7	2014	APOE4 protein, the isoform with arginines at residue 112 and 158, was found to form aggregates with more Abeta (P &lt; 0.001) and APOE (P &lt; 0.05) protein content in 10 mM FA than aggregates formed with either APOE3 or APOE2 protein.	Arginine	32-41	apolipoprotein E	Homo sapiens	0-4
24194506-9	2014	RESULTS: Primary outcomes are clamp-derived glucose-stimulated C-peptide secretion and maximal C-peptide response to arginine during hyperglycemia.	Arginine	117-125	insulin	Homo sapiens	95-104
23708056-0	2014	Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation.	Arginine	110-120	insulin	Homo sapiens	62-69
23708056-6	2014	RESULTS: We found that 6 months of L-arginine supplementation resulted in significant increases in insulin sensitivity (Delta1.1 mg/kg/min, P &lt; 0.01) and zinc levels (Delta1.5 mumol/L, P &lt; 0.001).	Arginine	35-45	insulin	Homo sapiens	99-106
25070816-0	2014	L-arginine enhances arginine deiminase induced human lymphoma cell growth inhibition through NF-kBp65 and p53 expression in vitro.	Arginine	0-10	tumor protein p53	Homo sapiens	106-109
25070816-6	2014	RESULTS AND CONCLUSIONS: L-arginine enhanced ADI-induced inhibited cell growth through expression of NF-kappaBp65 and p53 in a dose-dependent manner.	Arginine	25-35	tumor protein p53	Homo sapiens	118-121
23857333-8	2014	Ethanol suppressed arginine-methylation of FOXO3 promoting nuclear export and degradation of the JNK phosphorylated form.	Arginine	19-27	forkhead box O3	Homo sapiens	43-48
24205981-2	2014	In the present study, we show that, under normal growth conditions without stress, SERBP1 interacts with arginine-methylated and stress granule-associated proteins such as heterogeneous nuclear ribonucleoprotein A1, fragile X mental retardation protein and fragile X mental retardation syndrome-related protein 1 in an RNA-dependent manner.	Arginine	105-113	SERPINE1 mRNA binding protein 1	Homo sapiens	83-89
23857333-8	2014	Ethanol suppressed arginine-methylation of FOXO3 promoting nuclear export and degradation of the JNK phosphorylated form.	Arginine	19-27	mitogen-activated protein kinase 8	Homo sapiens	97-100
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	76-84	interferon regulatory factor 7	Homo sapiens	158-163
24084210-6	2014	Aortic uptake of radiolabeled L-arginine was attenuated in AI animals and was associated with a reduced expression of the L-arginine transporter CAT-1.	Arginine	30-40	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	145-150
24610624-0	2014	The effect of L-arginine supplementation on serum resistin concentration in insulin resistance in animal models.	Arginine	14-24	insulin	Homo sapiens	76-83
24610624-2	2014	AIM: The aim of this study was to examine the effects of L-arginine on the secretion of resistin in the context of insulin resistance in animal models.	Arginine	57-67	insulin	Homo sapiens	115-122
24610624-15	2014	CONCLUSIONS: L-arginine supplementation improves insulin sensitivity in rats fed a high-fat diet, independently of resistin activity.	Arginine	13-23	insulin	Homo sapiens	49-56
24953047-6	2014	The sequence analysis of the patient"s DNA revealed a new variant of apo E, which involves a single substitution of one serine (AGC) for one arginine (CGC) at position 142, thereby adding one negatively charged unit to apo E2.	Arginine	141-149	apolipoprotein E	Homo sapiens	69-74
24953047-9	2014	Since the presence of arginine at the amino acid residue 142 of apo E is considered to play an important role in binding to LDL receptors, the mutation apo E1 Nagoya (Arg142Ser) likely contributed to the expression of severe type III hyperlipoproteinemia in this patient.	Arginine	22-30	apolipoprotein E	Homo sapiens	64-69
24178787-3	2014	DESIGN: A total of 39 obese men and women with reduced GH secretion as determined by GHRH-arginine stimulation tests underwent magnetic resonance spectroscopy as part of a 12-month, double-blind, randomized, placebo-controlled trial comparing tesamorelin vs placebo.	Arginine	90-98	growth hormone releasing hormone	Homo sapiens	85-89
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	107-110	interferon regulatory factor 7	Homo sapiens	158-163
24482829-0	2014	Assessment of beta-cell function in young patients with type 2 diabetes: arginine-stimulated insulin secretion may reflect  beta-cell reserve.	Arginine	73-81	insulin	Homo sapiens	93-100
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	120-123	interferon regulatory factor 7	Homo sapiens	158-163
24482829-7	2014	The acute insulin and C-peptide responses to arginine (AIRarg and Ac-pepRarg, respectively) and to glucose (AIRglu and Ac-pepRglu, respectively)were estimated.Homeostasis model assessment of b-cell function(HOMA-b) andCpeptide assessments were also used for comparisons between patients with T2D and control participants.	Arginine	45-53	insulin	Homo sapiens	10-17
24482829-7	2014	The acute insulin and C-peptide responses to arginine (AIRarg and Ac-pepRarg, respectively) and to glucose (AIRglu and Ac-pepRglu, respectively)were estimated.Homeostasis model assessment of b-cell function(HOMA-b) andCpeptide assessments were also used for comparisons between patients with T2D and control participants.	Arginine	45-53	insulin	Homo sapiens	22-31
23875992-4	2014	Increased l-arginine uptake via hCAT-1 and NO synthesis by eNOS is associated with GDM.	Arginine	10-20	nitric oxide synthase 3	Homo sapiens	59-63
24482829-13	2014	arginine-stimulated insulin release is better preserved and can distinguish between patients with different disease duration and antidiabetic therapies.	Arginine	0-8	insulin	Homo sapiens	20-27
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Arginine	19-27	transmembrane serine protease 2	Homo sapiens	113-120
24249225-2	2014	FMRP, which is proposed to be involved in the translational regulation of specific neuronal messenger RNA (mRNA) targets, contains an arginine-glycine-glycine (RGG) box RNA binding domain that has been shown to bind with high affinity to G-quadruplex forming mRNA structures.	Arginine	134-142	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
23740826-3	2014	L-Arg is the precursor for the synthesis of nitric oxide (NO); a key signaling molecule via NO synthase (NOS).	Arginine	0-5	nitric oxide synthase 2	Homo sapiens	92-103
24418244-1	2014	It has been hypothesized that L-arginine improves exercise performance by increasing nitric oxide synthesis and levels of insulin and growth hormone (GH).	Arginine	30-40	insulin	Homo sapiens	122-129
24418244-1	2014	It has been hypothesized that L-arginine improves exercise performance by increasing nitric oxide synthesis and levels of insulin and growth hormone (GH).	Arginine	30-40	growth hormone 1	Homo sapiens	134-148
24418244-1	2014	It has been hypothesized that L-arginine improves exercise performance by increasing nitric oxide synthesis and levels of insulin and growth hormone (GH).	Arginine	30-40	growth hormone 1	Homo sapiens	150-152
25189392-5	2014	The availability of the amino acid L-Arg can be a key factor to control the expression of inducible nitric oxide synthase (NOS2) and cellular NO levels.	Arginine	35-40	nitric oxide synthase 2	Homo sapiens	123-127
24094605-1	2014	BACKGROUND: Removal of C-terminal lysine residues that are continuously exposed in lysing fibrin is an established anti-fibrinolytic mechanism dependent on the plasma carboxypeptidase TAFIa, which also removes arginines that are exposed at the time of fibrinogen clotting by thrombin.	Arginine	210-219	coagulation factor II, thrombin	Homo sapiens	275-283
24366091-3	2013	It was revealed that the FN-III10 is the most important module among FN-III7-10 in promoting fibronectin binding to HAP by optimizing the interaction energy; the arginine residues were observed to directly interact with the hydroxyl group of HAP through electrostatic forces and hydrogen bonding.	Arginine	162-170	fibronectin 1	Homo sapiens	93-104
24392309-4	2013	Data indicate that the functioning of common molecules with enzymatic activities, such are inducible nitric oxide synthase (iNOS), arginase, heme oxygenase-1 (HO-1) or indoleamine-2,3-dioxygenase (IDO), the bioavailability of their substrates (L-arginine, tryptophan, heme) and the cytotoxic and regulatory actions of their small gaseous products (NO, CO) can be the ultimate mechanisms responsible for effector or regulatory reactions.	Arginine	244-254	nitric oxide synthase 2	Homo sapiens	91-122
24392309-4	2013	Data indicate that the functioning of common molecules with enzymatic activities, such are inducible nitric oxide synthase (iNOS), arginase, heme oxygenase-1 (HO-1) or indoleamine-2,3-dioxygenase (IDO), the bioavailability of their substrates (L-arginine, tryptophan, heme) and the cytotoxic and regulatory actions of their small gaseous products (NO, CO) can be the ultimate mechanisms responsible for effector or regulatory reactions.	Arginine	244-254	nitric oxide synthase 2	Homo sapiens	124-128
24264242-7	2014	Since arginase and iNOS use the L-arginine as substrate, the amount of this amino acid available for both pathways is critical for parasite replication.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	19-23
24377430-8	2013	Our patient was very short (131.1cm, -4.9 standard deviation) at 14.3 years and showed profoundly impaired growth hormone responses to pharmacological stimulants: 0.15mug/L to insulin-induced hypoglycemia and 0.39mug/L to arginine.	Arginine	222-230	growth hormone 1	Homo sapiens	107-121
24376578-10	2013	In the MDM2 SNP309-TP53 R72P interaction analysis, we found that subjects with MDM2 309TT and TP53 Pro/Pro genotype, MDM2 309 TG and TP53 Arg/Pro genotype, and MDM2 309 GG and TP53 Pro/Pro genotype were associated with significantly increased risk of developing HCC as compared with the reference MDM2 309TT and TP53 Arg/Arg genotype.	Arginine	138-141	tumor protein p53	Homo sapiens	19-23
24314273-5	2013	The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity.	Arginine	83-93	interleukin 1 beta	Rattus norvegicus	4-12
24349476-4	2013	However, little is known about how histone arginine methylation regulates the expression of WUS and other genes.	Arginine	43-51	Homeodomain-like superfamily protein	Arabidopsis thaliana	92-95
24349250-7	2013	We demonstrate that this difference in calmodulin binding was due to the unique cysteine residue in the KCNQ2 subunit at aa 527 in Helix B, which corresponds to an arginine residue in other KCNQ subunits including KCNQ3.	Arginine	164-172	calmodulin 1	Homo sapiens	39-49
24314273-0	2013	L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1beta administration to normal rats.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	81-98
24178300-1	2013	Recent studies have documented the ability of prothrombin to spontaneously convert to the mature protease thrombin when Arg-320 becomes exposed to solvent for proteolytic attack upon mutation of residues in the activation domain.	Arginine	120-123	coagulation factor II, thrombin	Homo sapiens	49-57
24154564-3	2013	Indeed, it is well established that alphavbeta3 integrin plays a key role in tumor angiogenesis acting like a receptor for the extracellular matrix proteins like vitronectin, fibronectin through the arginine-glycine-aspartic acid (RGD) sequence.	Arginine	199-207	fibronectin 1	Homo sapiens	175-186
24314273-5	2013	The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity.	Arginine	83-93	interleukin 1 beta	Rattus norvegicus	180-188
23958999-9	2013	We have also found that SNAP and l-arginine induced AKT translocation into the nucleus of retinal neurons as well as other neuronal cell lines.	Arginine	33-43	AKT serine/threonine kinase 1	Homo sapiens	52-55
24319749-2	2013	Administration of L-arginine induced positive changes in the LPO-antioxidant enzyme system and elevated NO concentration in blood serum, whereas L-NAME, inhibitor of eNOS (NOS-III) increased LPO intensity via SOD inhibition and reduced NO content.	Arginine	18-28	lactoperoxidase	Homo sapiens	61-64
23958999-4	2013	Our results demonstrate that SNAP or l-arginine enhances AKT phosphorylation on both serine-473 and threonine-308 residues in a concentration and time-dependent manner.	Arginine	37-47	AKT serine/threonine kinase 1	Homo sapiens	57-60
24140967-2	2013	The involvement of dimethylarginine dimethylaminohydrolase (DDAH), the l-arginine analogue asymmetric dimethylarginine (ADMA) degrading enzyme, in FA-induced cell death in lung epithelial cells has not been investigated.	Arginine	71-81	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	19-58
24140967-2	2013	The involvement of dimethylarginine dimethylaminohydrolase (DDAH), the l-arginine analogue asymmetric dimethylarginine (ADMA) degrading enzyme, in FA-induced cell death in lung epithelial cells has not been investigated.	Arginine	71-81	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	60-64
24013475-4	2013	The EGF dressing (with EGF, Arg, VC) significantly enhanced the production of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) by CDS as compared to the EGF-free dressing (with Arg, VC).	Arginine	28-31	vascular endothelial growth factor A	Homo sapiens	78-112
24013475-4	2013	The EGF dressing (with EGF, Arg, VC) significantly enhanced the production of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) by CDS as compared to the EGF-free dressing (with Arg, VC).	Arginine	28-31	vascular endothelial growth factor A	Homo sapiens	114-118
23864434-13	2013	Arginine treatment increased IL-10 and sIgA levels when compared with the Sham and IO groups (p &lt; 0.05).	Arginine	0-8	interleukin 10	Mus musculus	29-34
24115463-6	2013	The LODs (S/N 3:1) were 0.012 muM for both dimethylarginines and 0.013 muM for L-arginine; the linearity of the method was from 0.1 to 20 muM for both dimethylarginines and from 1 to 200 muM for L-arginine.	Arginine	79-89	latexin	Homo sapiens	71-74
24115463-6	2013	The LODs (S/N 3:1) were 0.012 muM for both dimethylarginines and 0.013 muM for L-arginine; the linearity of the method was from 0.1 to 20 muM for both dimethylarginines and from 1 to 200 muM for L-arginine.	Arginine	79-89	latexin	Homo sapiens	71-74
24115463-6	2013	The LODs (S/N 3:1) were 0.012 muM for both dimethylarginines and 0.013 muM for L-arginine; the linearity of the method was from 0.1 to 20 muM for both dimethylarginines and from 1 to 200 muM for L-arginine.	Arginine	79-89	latexin	Homo sapiens	71-74
24065300-3	2013	Stat3-binding assay indicated that EGCG significantly interrupted Stat3 peptide binding at micromolar concentrations, and the docking experiments indicated that EGCG had a strong interaction with Arg-609, one of the key residues in the STAT3 SH2 domain that contributes greatly to Stat3 and phosphorylated peptide binding.	Arginine	196-199	signal transducer and activator of transcription 3	Homo sapiens	0-5
24065300-3	2013	Stat3-binding assay indicated that EGCG significantly interrupted Stat3 peptide binding at micromolar concentrations, and the docking experiments indicated that EGCG had a strong interaction with Arg-609, one of the key residues in the STAT3 SH2 domain that contributes greatly to Stat3 and phosphorylated peptide binding.	Arginine	196-199	signal transducer and activator of transcription 3	Homo sapiens	236-241
24121512-3	2013	Mutation of a conserved arginine residue (R298S) in the cytosolic domain of NBCe1 (SLC4A4) is linked to proximal renal tubular acidosis and results in impaired transport function, suggesting that the cytosolic domain plays a role in substrate permeation.	Arginine	24-32	solute carrier family 4 member 4	Homo sapiens	83-89
24278136-1	2013	Endothelial nitric oxide synthase 3 (NOS3) catalyzes the production of nitric oxide from L-arginine in endothelial cells.	Arginine	89-99	nitric oxide synthase 3	Homo sapiens	37-41
24246134-12	2013	In addition, the benefit of our innovative concept without prior functional hypothesis was demonstrated by data suggesting that NCAPG might contribute to vascular smooth muscle contraction by indirect effects on the NO pathway via modulation of arginine metabolism.	Arginine	245-253	non-SMC condensin I complex subunit G	Bos taurus	128-133
24089531-0	2013	NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.	Arginine	19-27	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	38-44
24089531-8	2013	In the present study, the presence of NDUFAF7 in the mitochondrial matrix has been confirmed, and it has been demonstrated that it is a protein methylase that symmetrically dimethylates the omega-N(G),N(G") atoms of residue Arg-85 in the NDUFS2 subunit of complex I.	Arginine	224-227	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	238-244
24140420-5	2013	EPG-11/PRMT-1 directly methylates arginines in the RGG domains of PGL-1 and PGL-3.	Arginine	34-43	Guanyl-specific ribonuclease pgl-1	Caenorhabditis elegans	66-71
23512866-5	2013	RESULTS: Five polymorphisms were nominally associated with plasma adiponectin levels in the meta-analysis (P = 0.035-1.02 x 10(-6) ) including a low frequency arginine to cysteine mutation (R55C) which reduced plasma adiponectin levels to &lt;15% of the mean.	Arginine	159-167	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
23512866-5	2013	RESULTS: Five polymorphisms were nominally associated with plasma adiponectin levels in the meta-analysis (P = 0.035-1.02 x 10(-6) ) including a low frequency arginine to cysteine mutation (R55C) which reduced plasma adiponectin levels to &lt;15% of the mean.	Arginine	159-167	adiponectin, C1Q and collagen domain containing	Homo sapiens	217-228
23859953-1	2013	Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS.	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	102-106
23859953-1	2013	Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS.	Arginine	64-69	nitric oxide synthase 2	Homo sapiens	102-106
24268778-3	2013	Both the low-complexity domain and the arginine-glycine rich domain of FUS contribute to assembly.	Arginine	39-47	FUS RNA binding protein	Homo sapiens	71-74
24510541-1	2013	Arginine is the substrate for nitric oxide synthases (NOS), and arginine availability regulates the production of nitric oxide.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	30-52
24190431-4	2013	Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04.	Arginine	36-44	major histocompatibility complex, class II, DR beta 1	Homo sapiens	70-78
24100041-5	2013	Double knockdown of the serine/arginine-rich (SR)-like proteins BCLAF1 and THRAP3 by siRNA resulted in a decrease in the nuclear speckle localization of WTAP, whereas the nuclear speckles were intact.	Arginine	31-39	thyroid hormone receptor associated protein 3	Homo sapiens	75-81
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Arginine	187-190	cannabinoid receptor 1	Homo sapiens	119-122
24152914-6	2013	When Cu,Zn-SOD that has been exposed to acrolein was subsequently analyzed by amino acid analysis, serine, histidine, arginine, threonine and lysine residues were particularly sensitive.	Arginine	118-126	superoxide dismutase 1	Homo sapiens	11-14
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Arginine	107-115	filamin A	Homo sapiens	205-209
24030822-2	2013	Consistent with these models, two arginine residues (Arg(436) and Arg(440)) within the MA helix of 5-hydroxytryptamine type 3A (5-HT3A) receptors act singularly as rate-limiting determinants of single-channel conductance (gamma).	Arginine	34-42	5-hydroxytryptamine receptor 3A	Homo sapiens	128-134
24030822-2	2013	Consistent with these models, two arginine residues (Arg(436) and Arg(440)) within the MA helix of 5-hydroxytryptamine type 3A (5-HT3A) receptors act singularly as rate-limiting determinants of single-channel conductance (gamma).	Arginine	53-56	5-hydroxytryptamine receptor 3A	Homo sapiens	128-134
24030822-2	2013	Consistent with these models, two arginine residues (Arg(436) and Arg(440)) within the MA helix of 5-hydroxytryptamine type 3A (5-HT3A) receptors act singularly as rate-limiting determinants of single-channel conductance (gamma).	Arginine	66-69	5-hydroxytryptamine receptor 3A	Homo sapiens	128-134
24030822-4	2013	We probed the majority of residues within the MA helix of the human 5-HT3A subunit using alanine- and arginine-scanning mutagenesis and the substituted cysteine accessibility method to determine their relative influences upon gamma.	Arginine	102-110	5-hydroxytryptamine receptor 3A	Homo sapiens	68-74
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	114-124	interleukin 1 beta	Homo sapiens	0-8
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	114-124	vascular endothelial growth factor A	Homo sapiens	22-26
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	175-185	interleukin 1 beta	Homo sapiens	0-8
24142467-4	2013	IL-1beta up-regulated VEGF mRNA (1.8-fold) and this response was attenuated by L-NAME (1.1-fold) and augmented by L-arginine (3.8-fold) at 4 h. Restoration of a NO pathway by L-arginine in L-NAME-treated cells resulted in elevated VEGF mRNA levels (2.2-fold).	Arginine	175-185	vascular endothelial growth factor A	Homo sapiens	22-26
24060963-5	2013	BRET experiments indicated the presence of constitutive C5aR-C5L2 heteromers, where C5a, but not C5a-des Arg, was able to induce further heteromer formation, which was inhibited by a C5aR-specific antagonist.	Arginine	105-108	complement C5a receptor 2	Homo sapiens	61-65
24060963-7	2013	There was also a significant difference in the levels of the anti-inflammatory cytokine IL-10 detected in HMDM following exposure to C5a compared with that seen for C5a-des Arg but no differences in the pro-inflammatory cytokines TNFalpha and IL-6.	Arginine	173-176	complement C5a receptor 1	Homo sapiens	165-168
23979600-8	2013	Replacement of two major acetylation sites of Rad53 with arginine reduces its activity and further suppresses the adaptation defect of rpd3Delta cells, indicating that Rpd3 facilitates adaptation by preventing Rad53 overactivation.	Arginine	57-65	histone deacetylase 1	Homo sapiens	168-172
23897760-8	2013	Fasting human C-peptide levels were similar between groups throughout the study, but only NKX6.1-high grafts displayed robust meal-, glucose- and arginine-responsive insulin secretion as early as 3 months post-transplant.	Arginine	146-154	insulin	Homo sapiens	166-173
24079887-8	2013	Using a novel chimeric C-furSema, we demonstrate that combining a single C-terminal arginine with the helical motif is necessary and sufficient for potent inhibition of binding of VEGF-A to Nrp1.	Arginine	84-92	vascular endothelial growth factor A	Homo sapiens	180-186
23954258-0	2013	Association of interleukin-13 SNP rs20541 (Arg&gt;Gln) to allergic rhinitis in an Asian population of ethnic Chinese in Singapore.	Arginine	43-46	interleukin 13	Homo sapiens	15-29
24019517-1	2013	In most cells, cationic amino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L (y(+)LAT) amino acid transporters.	Arginine	44-54	catalase	Homo sapiens	111-114
25606382-0	2013	The association between polymorphism of P53 codon 72 Arg/Pro and hepatocellular carcinoma susceptibility: evidence from a meta-analysis of 15 studies with 3704 cases.	Arginine	53-56	tumor protein p53	Homo sapiens	40-43
25606382-2	2013	Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	34-37	tumor protein p53	Homo sapiens	16-19
25606382-2	2013	Polymorphism of p53 gene codon 72 Arg/Pro (rs1042522) may influence the function of p53 protein and then affect the processing of carcinogenesis.	Arginine	34-37	tumor protein p53	Homo sapiens	84-87
25606382-3	2013	It has been suggested that p53 codon 72 Arg/Pro polymorphism is associated with susceptibility to hepatocellular carcinoma (HCC).	Arginine	40-43	tumor protein p53	Homo sapiens	27-30
25606382-10	2013	CONCLUSIONS/SIGNIFICANCE: This meta-analysis suggests that p53 codon 72 Arg/Pro polymorphism may be associated with the risk of HCC, especially in subgroup analysis of Asian and Caucasian population, hospital-based population, the female, and the individuals infected with hepatitis virus.	Arginine	72-75	tumor protein p53	Homo sapiens	59-62
24083983-4	2013	Drug rescue of P-gp processing mutants containing an arginine at each position in TM5 was used to identify positions facing the lipid or internal aqueous chamber.	Arginine	53-61	ATP binding cassette subfamily B member 1	Homo sapiens	15-19
23952216-6	2013	Conversely, GCF from Pg+ sites rapidly degraded synthetic LL-37 which was prevented in the presence of Arg- and Lys- gingipain inhibitors.	Arginine	103-106	cathelicidin antimicrobial peptide	Homo sapiens	58-63
23928483-3	2013	The apparent binding affinity of C18-Glu to l-arginine was obtained by fitting the plots of the change in mean molecular area of C18-Glu vs. l-arginine concentration.	Arginine	44-54	Bardet-Biedl syndrome 9	Homo sapiens	33-36
23928483-3	2013	The apparent binding affinity of C18-Glu to l-arginine was obtained by fitting the plots of the change in mean molecular area of C18-Glu vs. l-arginine concentration.	Arginine	44-54	Bardet-Biedl syndrome 9	Homo sapiens	129-132
23928483-3	2013	The apparent binding affinity of C18-Glu to l-arginine was obtained by fitting the plots of the change in mean molecular area of C18-Glu vs. l-arginine concentration.	Arginine	141-151	Bardet-Biedl syndrome 9	Homo sapiens	33-36
23928483-3	2013	The apparent binding affinity of C18-Glu to l-arginine was obtained by fitting the plots of the change in mean molecular area of C18-Glu vs. l-arginine concentration.	Arginine	141-151	Bardet-Biedl syndrome 9	Homo sapiens	129-132
23928483-5	2013	We found that N-stearoyl-l-glutamic acid (C18-l-Glu) had a stronger binding affinity to l-arginine as compared to N-stearoyl-d-glutamic acid (C18-d-Glu) at low to moderate surface pressures (below ~22mN/m).	Arginine	88-98	Bardet-Biedl syndrome 9	Homo sapiens	42-45
23928483-6	2013	The C18-d-Glu had stronger binding to l-arginine at higher surface pressure.	Arginine	38-48	Bardet-Biedl syndrome 9	Homo sapiens	4-7
23928483-8	2013	Herein, we present a mechanism for C18-l-Glu and C18-d-Glu interacting with l-arginine at the air/water interface.	Arginine	76-86	Bardet-Biedl syndrome 9	Homo sapiens	35-38
23928483-8	2013	Herein, we present a mechanism for C18-l-Glu and C18-d-Glu interacting with l-arginine at the air/water interface.	Arginine	76-86	Bardet-Biedl syndrome 9	Homo sapiens	49-52
23886590-6	2013	Homozygosity mapping with four microsatellite markers and subsequent direct sequencing of MYOC revealed a novel heterozygous transition c.1130 C&gt;G, substituting Threonine in to Arginine at codon 377 (p.Thr377Arg) of MYOC.	Arginine	180-188	myocilin	Homo sapiens	90-94
23886590-6	2013	Homozygosity mapping with four microsatellite markers and subsequent direct sequencing of MYOC revealed a novel heterozygous transition c.1130 C&gt;G, substituting Threonine in to Arginine at codon 377 (p.Thr377Arg) of MYOC.	Arginine	180-188	myocilin	Homo sapiens	219-223
23837945-8	2013	RESULTS: Patients carrying p53 Arg/Arg or Arg/Pro had a higher risk of esophageal SCC (P&lt;0.001, Odds ratio [OR] 4.98, 95% confidential interval [CI] 3.46-7.17), however, not found in MDM2 rs937283.	Arginine	31-34	tumor protein p53	Homo sapiens	27-30
23837945-8	2013	RESULTS: Patients carrying p53 Arg/Arg or Arg/Pro had a higher risk of esophageal SCC (P&lt;0.001, Odds ratio [OR] 4.98, 95% confidential interval [CI] 3.46-7.17), however, not found in MDM2 rs937283.	Arginine	35-38	tumor protein p53	Homo sapiens	27-30
23837945-8	2013	RESULTS: Patients carrying p53 Arg/Arg or Arg/Pro had a higher risk of esophageal SCC (P&lt;0.001, Odds ratio [OR] 4.98, 95% confidential interval [CI] 3.46-7.17), however, not found in MDM2 rs937283.	Arginine	35-38	tumor protein p53	Homo sapiens	27-30
23837945-9	2013	The risk of esophageal SCC increased significantly among patients carrying p53 Arg/Arg, or Arg/Pro and HPV16-seropositivity (P&lt;0.001, OR 9.33, 95% CI 5.44-16.0), but not for MDM2 rs937283.	Arginine	79-82	tumor protein p53	Homo sapiens	75-78
23837945-11	2013	CONCLUSION: HPV16 seropositivity synergized with p53 Arg/Arg or Arg/Pro and increased ESCC risk, especially in smokers or drinkers.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
23445176-8	2013	The subset of 12 patients with ALMS tested for GHRH-arg showed a significantly shorter stature than age-matched controls (154 7 +- 10 6 cm vs 162 9 +- 4 8 cm, P = 0 009) and a mild increase in BMI (Kg/m(2) ) (27 8 +- 4 8 vs 24 1 +- 2 5, P = 0 007).	Arginine	52-55	growth hormone releasing hormone	Homo sapiens	47-51
23949315-2	2013	IDH2 mutations are heterozygous; they alter a single arginine residue at position 140 or 172 and have distinct prognostic significance.	Arginine	53-61	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	tight junction protein 1	Homo sapiens	126-130
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	mitogen-activated protein kinase 8	Homo sapiens	228-251
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	mitogen-activated protein kinase 8	Homo sapiens	253-256
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	mitogen-activated protein kinase 1	Homo sapiens	259-296
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	mitogen-activated protein kinase 1	Homo sapiens	298-301
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	nuclear factor kappa B subunit 1	Homo sapiens	307-329
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	nuclear factor kappa B subunit 1	Homo sapiens	331-340
23897620-1	2013	Some species of the genus Mycoplasma code for the arginine deiminase pathway (ADI), which enables these bacteria to produce ATP from arginine by the successive reaction of three enzymes: arginine deiminase (ArcA), ornithine carbamoyltransferase (ArcB), and carbamate kinase (ArcC).	Arginine	50-58	arginine deiminase-like protein	Mycoplasma pneumoniae M129	207-211
23928057-6	2013	Both PRMT5 binding and histone H4 arginine 3 methylation (H4R3m2s) are decreased at the GLI1 promoter in MEN1-excised cells.	Arginine	34-42	menin 1	Homo sapiens	105-109
23552798-2	2013	Previous studies have linked alterations in local L-arginine metabolism, principally mediated by the enzymes arginase (Arg) and inducible nitric oxide synthase (iNOS), to pathological wound healing.	Arginine	50-60	nitric oxide synthase 2, inducible	Mus musculus	128-159
23552798-2	2013	Previous studies have linked alterations in local L-arginine metabolism, principally mediated by the enzymes arginase (Arg) and inducible nitric oxide synthase (iNOS), to pathological wound healing.	Arginine	50-60	nitric oxide synthase 2, inducible	Mus musculus	161-165
23812725-0	2013	P53 codon 72 Arg/Pro polymorphism and lung cancer risk in Asians: an updated meta-analysis.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	144-147	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-161
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	144-147	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-161
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-161
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-161
24005533-8	2013	However, a significant 2.21-fold increase in the chance of developing breast cancer was observed in the candidates carrying at least one allele Arg mutant in p21/CIP1 genotype (i.e., Ser/Arg + Arg/Arg) with age &gt;50 (OR = 2.21; 95 % CI 1.03-4.79).	Arginine	187-190	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
23146907-3	2013	Activation of Src, Erk1/2, Abl and Arg downstream of epidermal growth factor receptor (EGFR) modulates invadopodia activity through phosphorylation of the actin regulatory protein cortactin.	Arginine	35-38	epidermal growth factor receptor	Homo sapiens	53-85
23146907-3	2013	Activation of Src, Erk1/2, Abl and Arg downstream of epidermal growth factor receptor (EGFR) modulates invadopodia activity through phosphorylation of the actin regulatory protein cortactin.	Arginine	35-38	epidermal growth factor receptor	Homo sapiens	87-91
23146907-4	2013	In MDA-MB-231 breast cancer cells, Abl and Arg function downstream of Src to phosphorylate cortactin, promoting invadopodia ECM degradation activity and thus assigning a pro-invasive role for Ableson kinases.	Arginine	43-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
23146907-8	2013	Src-transformed Abl(-/-)/Arg(-/-) fibroblasts produced ECM degrading invadopodia containing pY421 cortactin, indicating that Abl/Arg are dispensable for invadopodia function in this system.	Arginine	25-28	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
23146907-8	2013	Src-transformed Abl(-/-)/Arg(-/-) fibroblasts produced ECM degrading invadopodia containing pY421 cortactin, indicating that Abl/Arg are dispensable for invadopodia function in this system.	Arginine	129-132	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
24011641-7	2013	Together with recent data demonstrating differences in the arginine methylation status of FUS in FTLD-FUS and ALS-FUS, these findings strongly imply at least partially distinct underlying disease mechanisms in these molecular subtypes of ALS and FTLD.	Arginine	59-67	FUS RNA binding protein	Homo sapiens	90-93
23860773-0	2013	P53 codon 72 Arg/Pro polymorphism and glioma risk: an updated meta-analysis.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
23860773-1	2013	P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
23860773-1	2013	P53 codon 72 Arg/Pro is a C/G variation upstream of the p53 gene on human chromosome 17p13.	Arginine	13-16	tumor protein p53	Homo sapiens	56-59
23860773-2	2013	Many case-control studies have investigated the association between p53 codon 72 Arg/Pro polymorphism and glioma risk but provided inconsistent findings.	Arginine	81-84	tumor protein p53	Homo sapiens	68-71
23860773-5	2013	The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to estimate the effect of p53 codon 72 Arg/Pro variant on the development of glioma.	Arginine	121-124	tumor protein p53	Homo sapiens	108-111
23860773-9	2013	Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a protective role in the development of glioblastoma.	Arginine	57-60	tumor protein p53	Homo sapiens	44-47
23860773-10	2013	The relationship of p53 codon 72 Arg/Pro polymorphism with the susceptibility to glioma needs further estimation by more individual studies with high quality across ethnicities.	Arginine	33-36	tumor protein p53	Homo sapiens	20-23
23715779-9	2013	Concerning the histological types of lung cancer, the p53 codon 72 variant exerts risk effect on the lung carcinogenesis in patients with adenocarcinoma (OR Arg/Pro vs. Arg/Arg = 1.10, 95 % CI = 1.00-1.22, P OR = 0.048).	Arginine	157-160	tumor protein p53	Homo sapiens	54-57
23715779-9	2013	Concerning the histological types of lung cancer, the p53 codon 72 variant exerts risk effect on the lung carcinogenesis in patients with adenocarcinoma (OR Arg/Pro vs. Arg/Arg = 1.10, 95 % CI = 1.00-1.22, P OR = 0.048).	Arginine	169-172	tumor protein p53	Homo sapiens	54-57
23715779-9	2013	Concerning the histological types of lung cancer, the p53 codon 72 variant exerts risk effect on the lung carcinogenesis in patients with adenocarcinoma (OR Arg/Pro vs. Arg/Arg = 1.10, 95 % CI = 1.00-1.22, P OR = 0.048).	Arginine	169-172	tumor protein p53	Homo sapiens	54-57
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Arginine	232-235	tumor protein p53	Homo sapiens	76-79
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Arginine	232-235	tumor protein p53	Homo sapiens	76-79
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Arginine	232-235	tumor protein p53	Homo sapiens	76-79
23812725-1	2013	The polymorphism of p53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer.	Arginine	60-63	tumor protein p53	Homo sapiens	20-23
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Arginine	232-235	tumor protein p53	Homo sapiens	76-79
23715779-10	2013	Additionally, subgroup analysis by the smoking status demonstrated that the p53 codon 72 variant seemed to play a protective role in lung carcinogenesis among the non-smokers but not the smokers in the contrast model of Arg/Pro vs. Arg/Arg (OR Arg/Pro vs. Arg/Arg = 0.71, 95 % CI = 0.50-1.00, P OR = 0.049).	Arginine	232-235	tumor protein p53	Homo sapiens	76-79
23812725-3	2013	Thus, we performed a meta-analysis by pooling all currently available case-control studies to estimate the effect of p53 codon 72 Arg/Pro polymorphism on the development of lung cancer.	Arginine	130-133	tumor protein p53	Homo sapiens	117-120
23812725-6	2013	The overall OR for the dominant genetic model indicated that the p53 codon 72 Arg/Pro variant was positively correlated with lung cancer risk (ORArg/Pro + Pro/Pro vs. Arg/Arg = 1.14, 95 %CI 1.07-1.23, P OR &lt; 0.001).	Arginine	78-81	tumor protein p53	Homo sapiens	65-68
23812725-6	2013	The overall OR for the dominant genetic model indicated that the p53 codon 72 Arg/Pro variant was positively correlated with lung cancer risk (ORArg/Pro + Pro/Pro vs. Arg/Arg = 1.14, 95 %CI 1.07-1.23, P OR &lt; 0.001).	Arginine	145-148	tumor protein p53	Homo sapiens	65-68
23812725-6	2013	The overall OR for the dominant genetic model indicated that the p53 codon 72 Arg/Pro variant was positively correlated with lung cancer risk (ORArg/Pro + Pro/Pro vs. Arg/Arg = 1.14, 95 %CI 1.07-1.23, P OR &lt; 0.001).	Arginine	145-148	tumor protein p53	Homo sapiens	65-68
23812725-10	2013	The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for lung cancer in the Asian population.	Arginine	57-60	tumor protein p53	Homo sapiens	44-47
24098712-0	2013	Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	24-32
23851158-8	2013	In particular, metabolites associated with arginine and proline metabolism, and glycerolipid metabolism, were markedly different between genotypes suggesting a constitutive role for PPARbeta/delta in the metabolism of these amino acids.	Arginine	43-51	peroxisome proliferator activator receptor delta	Mus musculus	182-190
23940050-4	2013	Using desGla prothrombin variants in which the individual cleavage sites have been singly rendered uncleavable, we find that loss of membrane binding and other Gla-dependent functions in the substrate leads to a decrease in the rate of cleavage at Arg(320) and a surprising increase in the rate of cleavage at Arg(271).	Arginine	248-251	coagulation factor II, thrombin	Homo sapiens	13-24
23940050-4	2013	Using desGla prothrombin variants in which the individual cleavage sites have been singly rendered uncleavable, we find that loss of membrane binding and other Gla-dependent functions in the substrate leads to a decrease in the rate of cleavage at Arg(320) and a surprising increase in the rate of cleavage at Arg(271).	Arginine	310-313	coagulation factor II, thrombin	Homo sapiens	13-24
24019961-2	2013	We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1).	Arginine	155-163	tumor protein p53	Homo sapiens	66-69
23980157-4	2013	Using mass spectrometry, we find that one of these core residues, arginine 42 of histone H3 (H3R42), is dimethylated in mammalian cells by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo, and we demonstrate that methylation of H3R42 stimulates transcription in vitro from chromatinized templates.	Arginine	66-74	protein arginine methyltransferase 6	Homo sapiens	215-251
23980157-4	2013	Using mass spectrometry, we find that one of these core residues, arginine 42 of histone H3 (H3R42), is dimethylated in mammalian cells by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo, and we demonstrate that methylation of H3R42 stimulates transcription in vitro from chromatinized templates.	Arginine	66-74	protein arginine methyltransferase 6	Homo sapiens	253-258
23889568-5	2013	CIEF immunoassay and immunoprecipitation mass spectrometry analysis identified peptides starting at residue Arg(5) as the main amino-terminal Abeta variants produced in the presence of tripartite BACE1 inhibitor in our cell culture model.	Arginine	108-111	amyloid beta precursor protein	Homo sapiens	142-147
23889568-5	2013	CIEF immunoassay and immunoprecipitation mass spectrometry analysis identified peptides starting at residue Arg(5) as the main amino-terminal Abeta variants produced in the presence of tripartite BACE1 inhibitor in our cell culture model.	Arginine	108-111	beta-secretase 1	Homo sapiens	196-201
23742976-9	2013	On the basis of docking studies, a direct hydrogen bond was formed between liensinine and arginine 482 which is a hot spot of BCRP for substrate specificity; and dauricine had hydrophobic interaction with BCRP.	Arginine	90-98	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	126-130
23742976-9	2013	On the basis of docking studies, a direct hydrogen bond was formed between liensinine and arginine 482 which is a hot spot of BCRP for substrate specificity; and dauricine had hydrophobic interaction with BCRP.	Arginine	90-98	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	205-209
24019961-2	2013	We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to arginine 72 (R72); one of these genes is macrophage colony stimulating factor (CSF1).	Arginine	155-163	DEAD-box helicase 17	Homo sapiens	71-74
23958248-2	2013	Optimal activity of iNOS is dependent on the intracellular availability of L-Arg and BH4 via prevention of NOS decoupling and subsequent ROS formation.	Arginine	75-80	nitric oxide synthase 2	Rattus norvegicus	20-24
23483183-1	2013	PURPOSE: It was shown that individuals homozygous for the Arg-encoding allele of codon 72 TP53 gene may have an increased risk to human papillomavirus (HPV)-related cervical carcinomas.	Arginine	58-61	tumor protein p53	Homo sapiens	90-94
23483183-9	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of codon 72 of TP53 gene was: 63.3, 34.7, and 2.0 % in the cervical carcinomas and 58.1, 33.8, and 8.1 % in the control group.	Arginine	29-32	tumor protein p53	Homo sapiens	84-88
23483183-9	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of codon 72 of TP53 gene was: 63.3, 34.7, and 2.0 % in the cervical carcinomas and 58.1, 33.8, and 8.1 % in the control group.	Arginine	33-36	tumor protein p53	Homo sapiens	84-88
23483183-9	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of codon 72 of TP53 gene was: 63.3, 34.7, and 2.0 % in the cervical carcinomas and 58.1, 33.8, and 8.1 % in the control group.	Arginine	33-36	tumor protein p53	Homo sapiens	84-88
23483183-11	2013	CONCLUSIONS: The results indicate that carriers of Arg allele of codon 72 TP53 gene have an increased risk for development of cervical carcinoma in Serbian women.	Arginine	51-54	tumor protein p53	Homo sapiens	74-78
23958248-9	2013	CONCLUSIONS: Fine-tuning of iNOS function by L-Arg and BH4 supplementation in the transduced vasculature augments the therapeutic potential of gene therapy with iNOS for the prevention of restenosis.	Arginine	45-50	nitric oxide synthase 2	Rattus norvegicus	28-32
23958248-9	2013	CONCLUSIONS: Fine-tuning of iNOS function by L-Arg and BH4 supplementation in the transduced vasculature augments the therapeutic potential of gene therapy with iNOS for the prevention of restenosis.	Arginine	45-50	nitric oxide synthase 2	Rattus norvegicus	161-165
23774601-6	2013	Treatment with gamma interferon (IFN-gamma), l-arginine, and tetrahydrobiopterin enhanced expression of NOS2 and NOS3 isoforms, as well as NO production.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	104-108
23835419-4	2013	Many arginine suppressors that mimic drug-rescue have been identified in the P-gp transmembrane (TM) domains (TMDs) that rescue by forming hydrogen bonds with residues in adjacent helices to promote packing of the TM segments.	Arginine	5-13	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
24067187-8	2013	Specifically, the tetrahydrobiopterin (BH4)-dependent enzyme nitric oxide synthase (NOS) showed significantly lower activities (citrulline-to-arginine ratio decreased from baseline median 0.21 to 0.14 at 6265 m), indicating lower NO availability resulting in less vasodilatative activity.	Arginine	142-150	nitric oxide synthase 2	Homo sapiens	61-82
23913118-4	2013	We analyzed the GH-IGF1 axis by GHRH-arginine test in 30 healthy adolescents with normal stature during the transition period from 14 to 18 years.	Arginine	37-45	growth hormone releasing hormone	Homo sapiens	32-36
23774601-6	2013	Treatment with gamma interferon (IFN-gamma), l-arginine, and tetrahydrobiopterin enhanced expression of NOS2 and NOS3 isoforms, as well as NO production.	Arginine	45-55	nitric oxide synthase 3	Homo sapiens	113-117
23333044-2	2013	We studied safety and efficacy of repeated inhalations of nebulized L-arginine, the substrate for NO synthase (NOS), in patients with CF.	Arginine	68-78	nitric oxide synthase 2	Homo sapiens	98-109
23812551-10	2013	On postoperative day 7, CD4(+) T cells, NK cells, IgM and IgG levels of the arginine-supplemented group increased prominently and were significantly higher than those of the control group and those on preoperative day 1.	Arginine	76-84	CD4 molecule	Homo sapiens	24-27
23635657-2	2013	FUS contains a methylated arginine-glycine-glycine domain that is required for transport into the nucleus.	Arginine	26-34	FUS RNA binding protein	Homo sapiens	0-3
23830845-9	2013	Excessive arginase activity reduces the l-arginine supply for nitric oxide synthase (NOS), causing it to become uncoupled and produce superoxide and less NO.	Arginine	40-50	nitric oxide synthase 2	Homo sapiens	62-83
23582621-1	2013	OBJECTIVES: Monomethylated L-arginine (L-NMMA) has been proven to be a strong inhibitor of nitric oxide synthase (NOS) and has been used as an exogenous tool in experimental evaluation of cerebrovascular reactivity leading to vasoconstriction.	Arginine	27-37	nitric oxide synthase 2	Homo sapiens	91-112
23940600-4	2013	Spectroscopic, chemical, molecular modelling and biochemical studies reported here show that the color change is mediated by selective recognition between the conjugate base of the sulfonamide group within the probe and the conjugate acid of the arginine residue within the active site of both hNAT1 and mNat2.	Arginine	246-254	N-acetyltransferase 2 (arylamine N-acetyltransferase)	Mus musculus	304-309
24479328-5	2013	It was shown that the affinity constant of iNOS affinity for L-arginine is 5.4-fold lower than for eNOS of blood lymphocytes of persons in the control group.	Arginine	61-71	nitric oxide synthase 2	Homo sapiens	43-47
24090136-10	2013	While there has been speculation that arginine methylation within these RGG domains modulates the incorporation of FUS into stress granules, our results demonstrate that this post-translational modification is not involved.	Arginine	38-46	FUS RNA binding protein	Homo sapiens	115-118
23844999-6	2013	and (ii) arginine derivatives designed as NPFF receptor ligands.	Arginine	9-17	neuropeptide FF-amide peptide precursor	Homo sapiens	42-46
23904475-4	2013	We now report that, in response to IL-1beta, the p65 subunit of NF-kappaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).	Arginine	93-101	interleukin 1 beta	Homo sapiens	35-43
23904475-4	2013	We now report that, in response to IL-1beta, the p65 subunit of NF-kappaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).	Arginine	93-101	protein arginine methyltransferase 5	Homo sapiens	114-150
23904475-4	2013	We now report that, in response to IL-1beta, the p65 subunit of NF-kappaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).	Arginine	93-101	protein arginine methyltransferase 5	Homo sapiens	152-157
23978640-2	2013	This SNP causes Arg to Gln (Q) substitution at position 110 in the mature IL-13 protein.	Arginine	16-19	interleukin 13	Homo sapiens	74-79
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Arginine	140-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Arginine	140-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Arginine	140-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
23831350-0	2013	Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.	Arginine	64-72	PR/SET domain 4	Rattus norvegicus	27-30
23831350-0	2013	Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.	Arginine	64-72	PR/SET domain 4	Rattus norvegicus	31-36
23833192-4	2013	FUS recruitment is mediated by the arginine/glycine-rich domains, which interact directly with PAR.	Arginine	35-43	FUS RNA binding protein	Homo sapiens	0-3
23836915-3	2013	EBNA1 localizes to cellular chromosomes (chromatin) via its chromosome binding domains (CBDs), which are rich in glycine and arginine residues.	Arginine	125-133	EBNA-1	Human gammaherpesvirus 4	0-5
23836915-5	2013	Mutation analyses revealed that stepwise substitution of arginine residues within the CBD1 (amino acids 40-54) and CBD2 (amino acids 328-377) regions with alanines progressively impaired chromosome binding activity of EBNA1.	Arginine	57-65	EBNA-1	Human gammaherpesvirus 4	218-223
23836915-6	2013	The complete arginine-to-alanine substitutions within the CBD1 and -2 regions abolished the ability of EBNA1 to stably maintain EBV-derived oriP plasmids in dividing cells.	Arginine	13-21	EBNA-1	Human gammaherpesvirus 4	103-108
23775088-2	2013	The prothrombinase complex assembled on the surface of platelets converts prothrombin to thrombin by cleaving at Arg-271 and Arg-320.	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	4-15
23775088-2	2013	The prothrombinase complex assembled on the surface of platelets converts prothrombin to thrombin by cleaving at Arg-271 and Arg-320.	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	7-15
23775088-2	2013	The prothrombinase complex assembled on the surface of platelets converts prothrombin to thrombin by cleaving at Arg-271 and Arg-320.	Arginine	125-128	coagulation factor II, thrombin	Homo sapiens	4-15
23775088-2	2013	The prothrombinase complex assembled on the surface of platelets converts prothrombin to thrombin by cleaving at Arg-271 and Arg-320.	Arginine	125-128	coagulation factor II, thrombin	Homo sapiens	7-15
23775088-10	2013	Burial of Arg-320 prevents prothrombin autoactivation and directs prothrombinase to cleave at Arg-271 first.	Arginine	10-13	coagulation factor II, thrombin	Homo sapiens	27-38
23894162-1	2013	BACKGROUND: Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R).	Arginine	204-212	paraoxonase 1	Homo sapiens	12-25
23775088-11	2013	Reversal of the local electrostatic potential then redirects prothrombinase toward Arg-320, leading to thrombin generation via the prethrombin-2 intermediate.	Arginine	83-86	coagulation factor II, thrombin	Homo sapiens	64-72
23604405-1	2013	Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, alpha-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties.	Arginine	131-139	glucagon	Homo sapiens	100-108
23604405-1	2013	Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, alpha-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties.	Arginine	131-139	nardilysin convertase	Homo sapiens	0-10
23894162-1	2013	BACKGROUND: Paraoxonase 1 (PON1), an esterase that hydrolyzes toxic organophosphates and has antioxidative and antiatherogenic properties, contains a common polymorphism at position 192: glutamine (Q) or arginine (R).	Arginine	204-212	paraoxonase 1	Homo sapiens	27-31
23707396-2	2013	Arg promotes actin-based cell protrusions and spreading, and inhibits cell migration by attenuating stress fiber formation and contractility via activation of the RhoA inhibitor, p190RhoGAP, and by regulating focal adhesion dynamics also via CrkII phosphorylation.	Arginine	0-3	ras homolog family member A	Homo sapiens	163-167
23707396-2	2013	Arg promotes actin-based cell protrusions and spreading, and inhibits cell migration by attenuating stress fiber formation and contractility via activation of the RhoA inhibitor, p190RhoGAP, and by regulating focal adhesion dynamics also via CrkII phosphorylation.	Arginine	0-3	CRK proto-oncogene, adaptor protein	Homo sapiens	242-247
23707396-5	2013	The transfected 1BSCTS Arg isoform has a nuclear distribution and phosphorylates CrkII in the nucleus, whilst the other isoforms are detected in the cytoplasm.	Arginine	23-26	CRK proto-oncogene, adaptor protein	Homo sapiens	81-86
23649769-1	2013	The close relationship between aflatoxins and 249ser TP53 gene mutation (AGG to AGT, Arg to Ser) in hepatocellular carcinoma (HCC) makes this mutation an indirect indicator of dietary contamination with this toxin.	Arginine	85-88	tumor protein p53	Homo sapiens	53-57
24209971-5	2013	By using genomic DNA from dogs of various breeds with and without ITP, sequencing of PCR products encompassing all coding regions and exon-intron boundaries for these 3 genes revealed 4 single-nucleotide polymorphisms in ITGA2B resulting in amino acid polymorphisms in the canine genome, 3 previously reported and 1 newly identified (Gly[GGG]/Arg[AGG] at amino acid position 576 of ITGA2B.	Arginine	343-346	integrin subunit alpha 2b	Canis lupus familiaris	221-227
23319437-1	2013	L-arginine may enhance endurance performance mediated by two primary mechanisms including enhanced secretion of endogenous growth hormone (GH) and as a precursor of nitric oxide (NO); however, research in trained participants has been equivocal.	Arginine	0-10	growth hormone 1	Homo sapiens	123-137
23866860-1	2013	BACKGROUND: Protein arginine methyltransferase 6 (PRMT6) is a nuclear enzyme that methylates arginine residues on histones and transcription factors.	Arginine	20-28	protein arginine methyltransferase 6	Homo sapiens	50-55
23683469-5	2013	The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg).	Arginine	115-123	tumor protein p53	Homo sapiens	4-7
23683469-5	2013	The p53 gene contains a single nucleotide polymorphism at codon 72 of exon 4 which encodes either proline (Pro) or arginine (Arg).	Arginine	125-128	tumor protein p53	Homo sapiens	4-7
23909418-3	2013	The proinsulin consists of six components: an initiating methionine, 48 amino acids from human growth hormones (HGH, used as the protection peptide), first connecting Arg-residue, B-chain of insulin, and second connecting Arg-peptide and A-chain of insulin.	Arginine	167-170	insulin	Homo sapiens	4-14
23909418-3	2013	The proinsulin consists of six components: an initiating methionine, 48 amino acids from human growth hormones (HGH, used as the protection peptide), first connecting Arg-residue, B-chain of insulin, and second connecting Arg-peptide and A-chain of insulin.	Arginine	167-170	insulin	Homo sapiens	7-14
23909418-3	2013	The proinsulin consists of six components: an initiating methionine, 48 amino acids from human growth hormones (HGH, used as the protection peptide), first connecting Arg-residue, B-chain of insulin, and second connecting Arg-peptide and A-chain of insulin.	Arginine	222-225	insulin	Homo sapiens	4-14
23909418-3	2013	The proinsulin consists of six components: an initiating methionine, 48 amino acids from human growth hormones (HGH, used as the protection peptide), first connecting Arg-residue, B-chain of insulin, and second connecting Arg-peptide and A-chain of insulin.	Arginine	222-225	insulin	Homo sapiens	7-14
23632240-6	2013	The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301).	Arginine	22-25	tumor protein p53	Homo sapiens	17-21
23632240-6	2013	The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301).	Arginine	26-29	tumor protein p53	Homo sapiens	17-21
23632240-8	2013	CONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T&gt;C, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population.	Arginine	107-110	tumor protein p53	Homo sapiens	102-106
23632240-8	2013	CONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T&gt;C, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population.	Arginine	111-114	tumor protein p53	Homo sapiens	102-106
23818613-2	2013	Mpr1 mediates the L-proline and L-arginine metabolism by acetylating L-Delta(1)-pyrroline-5-carboxylate, leading to the L-arginine-dependent production of nitric oxide, which confers oxidative stress tolerance.	Arginine	32-42	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
23818613-2	2013	Mpr1 mediates the L-proline and L-arginine metabolism by acetylating L-Delta(1)-pyrroline-5-carboxylate, leading to the L-arginine-dependent production of nitric oxide, which confers oxidative stress tolerance.	Arginine	120-130	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	0-4
23709221-1	2013	Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function.	Arginine	87-90	CF transmembrane conductance regulator	Homo sapiens	59-63
23709221-1	2013	Previous studies have identified two salt bridges in human CFTR chloride ion channels, Arg(352)-Asp(993) and Arg(347)-Asp(924), that are required for normal channel function.	Arginine	109-112	CF transmembrane conductance regulator	Homo sapiens	59-63
23696643-5	2013	PID bound to iNOS heme to generate an irreversible PID-iNOS monomer complex that could not be converted to active dimers by tetrahydrobiopterin (H4B) and l-arginine (Arg).	Arginine	166-169	nitric oxide synthase 2	Homo sapiens	13-17
23847624-3	2013	In endothelial cells, NO is generated by endothelial nitric oxide synthase (eNOS) through the conversion of its substrate, l-arginine to l-citrulline.	Arginine	123-133	nitric oxide synthase 3	Homo sapiens	41-74
23696643-5	2013	PID bound to iNOS heme to generate an irreversible PID-iNOS monomer complex that could not be converted to active dimers by tetrahydrobiopterin (H4B) and l-arginine (Arg).	Arginine	166-169	nitric oxide synthase 2	Homo sapiens	55-59
23847616-1	2013	Nitric oxide (NO) generated through L-arginine metabolism by endothelial nitric oxide synthase (eNOS) is an important regulator of the vessel wall.	Arginine	36-46	nitric oxide synthase 3	Homo sapiens	61-94
23714778-4	2013	Tdrkh partners with Miwi and Miwi2 via symmetrically dimethylated arginine residues in Miwi and Miwi2.	Arginine	66-74	tudor and KH domain containing	Homo sapiens	0-5
23449734-8	2013	Interestingly, the integrin-blocking peptide Arg-Gly-Asp-Ser, as well as integrin alpha5beta1 function-blocking antibodies, inhibited the effects of TGF-beta1 and its combination with methacholine on cell proliferation.	Arginine	45-48	transforming growth factor beta 1	Homo sapiens	149-158
23604587-5	2013	With respect to other concomitant pathologies commonly found in elderly individuals, cases with TDP-43 had a greater prevalence of argyrophilic grains (ARG) (40 vs. 18.6 %) and overall ARG density (moderate vs. sparse).	Arginine	152-155	TAR DNA binding protein	Homo sapiens	96-102
23604587-5	2013	With respect to other concomitant pathologies commonly found in elderly individuals, cases with TDP-43 had a greater prevalence of argyrophilic grains (ARG) (40 vs. 18.6 %) and overall ARG density (moderate vs. sparse).	Arginine	185-188	TAR DNA binding protein	Homo sapiens	96-102
23604587-7	2013	These results indicate deposition of TDP-43 occurs in a substantial subset of cognitively normal elderly subjects and is more common in those with ARG, supporting some previous studies linking pathological TDP-43 deposition with ARG and other pathological tau protein deposits.	Arginine	147-150	TAR DNA binding protein	Homo sapiens	37-43
23604587-7	2013	These results indicate deposition of TDP-43 occurs in a substantial subset of cognitively normal elderly subjects and is more common in those with ARG, supporting some previous studies linking pathological TDP-43 deposition with ARG and other pathological tau protein deposits.	Arginine	147-150	TAR DNA binding protein	Homo sapiens	206-212
23604587-7	2013	These results indicate deposition of TDP-43 occurs in a substantial subset of cognitively normal elderly subjects and is more common in those with ARG, supporting some previous studies linking pathological TDP-43 deposition with ARG and other pathological tau protein deposits.	Arginine	229-232	TAR DNA binding protein	Homo sapiens	37-43
23604587-7	2013	These results indicate deposition of TDP-43 occurs in a substantial subset of cognitively normal elderly subjects and is more common in those with ARG, supporting some previous studies linking pathological TDP-43 deposition with ARG and other pathological tau protein deposits.	Arginine	229-232	TAR DNA binding protein	Homo sapiens	206-212
23541506-0	2013	Effect of different arginine methylations on the thermodynamics of Tat peptide binding to HIV-1 TAR RNA.	Arginine	20-28	RNA binding motif protein 8A	Homo sapiens	96-99
23541506-4	2013	This paper describes a comparative study of the thermodynamics of unmodified and modified Tat peptide interaction with TAR RNA, where the peptide is methylated at epsilon (e) and eta (eta) nitrogen atoms of guanidinium group of arginine side chain at position 52 or 53.	Arginine	228-236	RNA binding motif protein 8A	Homo sapiens	119-122
23696563-0	2013	Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth hormone and insulin release in mice.	Arginine	71-81	somatostatin	Mus musculus	11-23
23897679-10	2013	Furthermore, low levels of tetrahydrobiopterin (BH4) and L-arginine the rate limiting cofactor and substrate for endothelial nitric oxide synthase (eNOS), can cause the uncoupling of eNOS, resulting in decreased NO production and increased ROS production.	Arginine	57-67	nitric oxide synthase 3	Homo sapiens	113-146
23793604-7	2013	The P53 Arg/Pro genotype or Pro/Pro genotype was significantly associated with an increased risk of developing breast cancer, compared to the P53 Arg/Arg genotype in both the case-control sets (all P &lt; 0.05).	Arginine	8-11	tumor protein p53	Homo sapiens	4-7
23486015-6	2013	Our results show that PELP1 recognizes histones modified by arginine and lysine dimethylation.	Arginine	60-68	proline, glutamate and leucine rich protein 1	Homo sapiens	22-27
23486015-9	2013	Chromatin immunoprecipitation assays revealed that PELP1 alters histone H3 arginine methylation status at ERalpha target gene promoters.	Arginine	75-83	proline, glutamate and leucine rich protein 1	Homo sapiens	51-56
23486015-9	2013	Chromatin immunoprecipitation assays revealed that PELP1 alters histone H3 arginine methylation status at ERalpha target gene promoters.	Arginine	75-83	estrogen receptor 1	Homo sapiens	106-113
23486015-11	2013	The critical role of PELP1 status in modulating arginine methylation status was also observed through in vivo studies where PELP1 knockdown mediated decreased tumorigenesis correlated with decreased arginine dimethylation.	Arginine	48-56	proline, glutamate and leucine rich protein 1	Homo sapiens	21-26
23486015-11	2013	The critical role of PELP1 status in modulating arginine methylation status was also observed through in vivo studies where PELP1 knockdown mediated decreased tumorigenesis correlated with decreased arginine dimethylation.	Arginine	48-56	proline, glutamate and leucine rich protein 1	Homo sapiens	124-129
23486015-11	2013	The critical role of PELP1 status in modulating arginine methylation status was also observed through in vivo studies where PELP1 knockdown mediated decreased tumorigenesis correlated with decreased arginine dimethylation.	Arginine	199-207	proline, glutamate and leucine rich protein 1	Homo sapiens	21-26
23486015-11	2013	The critical role of PELP1 status in modulating arginine methylation status was also observed through in vivo studies where PELP1 knockdown mediated decreased tumorigenesis correlated with decreased arginine dimethylation.	Arginine	199-207	proline, glutamate and leucine rich protein 1	Homo sapiens	124-129
23486015-13	2013	Our findings show PELP1 is a reader of histone arginine methyl modifications and deregulation promotes tumor proliferation via epigenetic alterations at ERalpha target promoters.	Arginine	47-55	proline, glutamate and leucine rich protein 1	Homo sapiens	18-23
23486015-13	2013	Our findings show PELP1 is a reader of histone arginine methyl modifications and deregulation promotes tumor proliferation via epigenetic alterations at ERalpha target promoters.	Arginine	47-55	estrogen receptor 1	Homo sapiens	153-160
23696563-2	2013	It has been hypothesized that l-Arg stimulates GH release by lowering hypothalamic somatostatin (SST) tone.	Arginine	30-35	somatostatin	Mus musculus	83-95
23935755-0	2013	Stimulation of insulin secretion by large-dose oral arginine administration in healthy adults.	Arginine	52-60	insulin	Homo sapiens	15-22
23423302-1	2013	The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial.	Arginine	92-102	nitric oxide synthase 2	Homo sapiens	53-74
23423302-1	2013	The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial.	Arginine	104-107	nitric oxide synthase 2	Homo sapiens	53-74
23935755-1	2013	The effects of large-dose oral arginine administration on the secretion of insulin by islet beta-cells in healthy adults were determined.	Arginine	31-39	insulin	Homo sapiens	75-82
23935755-8	2013	Large-dose oral arginine administration may slightly stimulate insulin secretion by islet beta-cells in healthy adults with normal glucose tolerance in a manner that is independent of glucose concentration.	Arginine	16-24	insulin	Homo sapiens	63-70
23608612-1	2013	The present study aimed to design a PEGylated VIP derivative, [Arg(15, 20, 21), Leu(17)]-VIP-GRR (IK312532), with improved metabolic stability, and develop its respirable powder (RP) formulation for inhalation therapy.	Arginine	63-66	vasoactive intestinal peptide	Rattus norvegicus	46-49
23375628-4	2013	Additionally, Arg1 inhibits nitric oxide-mediated inflammatory pathways by competing with iNOS for the same substrate, l-arginine.	Arginine	119-129	nitric oxide synthase 2	Homo sapiens	90-94
23840386-2	2013	By site-directed mutatgenesis, we have previously shown that basic amino acids in positions 143 and 192 (Arg and Lys respectively) of the human mast cell chymase are responsible for an acidic amino acid residue preference in the P2" position of substrates.	Arginine	105-108	chymase 1	Homo sapiens	154-161
23686481-5	2013	Site-directed mutagenesis established that the combination of arginine at residue 11 and glutamic acid at residue 35 in KIR2DL3*005 were critical to the observed phenotype.	Arginine	62-70	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3	Homo sapiens	120-127
23589577-10	2013	Arginine depletion by ADI significantly increased tumor necrosis factor alpha and decreased interleukin-10 (IL-10) and IL-12p40 secretion.	Arginine	0-8	tumor necrosis factor	Homo sapiens	50-77
23624782-9	2013	The combination of SNP309 GG + TG and TP53 codon 72 Arg/Arg significantly increased endometrial cancer risk.	Arginine	52-55	tumor protein p53	Homo sapiens	38-42
23624782-9	2013	The combination of SNP309 GG + TG and TP53 codon 72 Arg/Arg significantly increased endometrial cancer risk.	Arginine	56-59	tumor protein p53	Homo sapiens	38-42
23624782-12	2013	The presence of the SNP309 G allele and TP53 codon 72 Arg/Arg genotype is associated with an increased risk of endometrial cancer in Japanese women.	Arginine	54-57	tumor protein p53	Homo sapiens	40-44
23624782-12	2013	The presence of the SNP309 G allele and TP53 codon 72 Arg/Arg genotype is associated with an increased risk of endometrial cancer in Japanese women.	Arginine	58-61	tumor protein p53	Homo sapiens	40-44
23709277-7	2013	Mutational analysis of Apt1-S showed that three guanines of the motif are important for Runt binding as are the three guanines of RDE, which are directly recognized by three arginine residues of the Runt domain.	Arginine	174-182	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	23-27
23608612-1	2013	The present study aimed to design a PEGylated VIP derivative, [Arg(15, 20, 21), Leu(17)]-VIP-GRR (IK312532), with improved metabolic stability, and develop its respirable powder (RP) formulation for inhalation therapy.	Arginine	63-66	vasoactive intestinal peptide	Rattus norvegicus	89-92
23504664-7	2013	Based on the virtual screening and on the results obtained above, the activity may be due to their capacity to reduce the NO synthesis by blocking the bind of L-Arg in the active site of iNOS, the compounds binding the synthase by hydrogen bonds between the NH (2 and/or 4) of thiosemicarbazide fragment (Th-2-8) or N2/N3 from azole cycles and by the thiol function (Th-9-22).	Arginine	159-164	nitric oxide synthase 2	Homo sapiens	187-191
23524183-6	2013	The occurrence of anticonvulsant activity of GSE was significantly delayed in the presence of selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (60 mg/kg), which was inhibited by the NO precursor, L-arginine (500 mg/kg).	Arginine	222-232	nitric oxide synthase 2	Rattus norvegicus	104-135
23524183-6	2013	The occurrence of anticonvulsant activity of GSE was significantly delayed in the presence of selective inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (60 mg/kg), which was inhibited by the NO precursor, L-arginine (500 mg/kg).	Arginine	222-232	nitric oxide synthase 2	Rattus norvegicus	137-141
23659383-10	2013	Mutation of Arg2116 to hydrophobic residues resulted in variable decreases in stability and thrombin generation parameters, suggesting a role of this Arg residue contributing to FVIII structure.	Arginine	12-15	coagulation factor II, thrombin	Homo sapiens	92-100
23552121-2	2013	L-Arginine and its homolog L-homoarginine are competitive substrates of nitric oxide synthase (NOS), whereas asymmetric dimethylarginine (ADMA) is a NOS inhibitor.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	72-93
23602444-0	2013	Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors.	Arginine	42-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
23602444-2	2013	Among all the peptides, cyclic decapeptide C[RW]5 containing alternative arginine (R) and tryptophan (W) residues was found to be the most potent Src kinase inhibitor.	Arginine	73-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	146-149
23602444-4	2013	Thus, the cyclic nature, the presence of arginine, ring size, and the number of amino acids in the structure of the peptide were found to be critical in Src kinase inhibitory potency.	Arginine	41-49	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	153-156
23404443-6	2013	Insulin levels were negatively correlated with variables of vagal control, reaching significance for rMSSD and log10HF, but not for pvRSA, during the last four phases of the hyperglycaemic clamp (hyperglycaemic second phase, GLP-1 first and second phases, and arginine).	Arginine	260-268	insulin	Homo sapiens	0-7
23918883-8	2013	The initial results showed an activation of both l-arginine influx and via system y (+ )L associated with reduced intraplatelet cGMP levels in periodontitis patients and increased systemic levels of CRP.	Arginine	49-59	C-reactive protein	Homo sapiens	199-202
23516040-4	2013	The central region in apoA-I sequence is suggested to influence the proper positioning of cholesterol molecule toward LCAT active center with major contribution of arginine residue(s).	Arginine	164-172	apolipoprotein A1	Homo sapiens	22-28
23771660-6	2013	When the inhibitor and stimulator of TLR4, namely L-Arg and L-NAME, were added respectively, lung injury was correspondingly relieved or aggravated (P&lt;0.05 or P&lt;0.01).	Arginine	50-55	toll-like receptor 4	Rattus norvegicus	37-41
23583342-2	2013	In our previous study, an elevated level of dimethylarginine dimethylaminohydrolase 1 (DDAH1) protein was observed in different brain regions of acute methamphetamine (METH) treated rats, indicating the possibility of an enhanced expression of protein nitration that is mediated by excess NO through the DDAH1/ADMA (Asymmetric Dimethylated l-arginine)/NOS (Nitric Oxide Synthase) pathway.	Arginine	340-350	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	44-85
23583342-2	2013	In our previous study, an elevated level of dimethylarginine dimethylaminohydrolase 1 (DDAH1) protein was observed in different brain regions of acute methamphetamine (METH) treated rats, indicating the possibility of an enhanced expression of protein nitration that is mediated by excess NO through the DDAH1/ADMA (Asymmetric Dimethylated l-arginine)/NOS (Nitric Oxide Synthase) pathway.	Arginine	340-350	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	87-92
23564481-0	2013	Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk.	Arginine	37-40	tumor protein p53	Homo sapiens	24-27
23782374-4	2013	Genetic analysis found a C-T exchange in exon 2 at cDNA position 568, which changes the codon CGG for arginine to TGG for tryptophan (R190W) of the runt-related transcription factor 2 RUNX2 gene.	Arginine	102-110	RUNX family transcription factor 2	Homo sapiens	184-189
23629834-5	2013	Substitution of a conserved arginine to lysine in the first beta-strand of ERF189 relaxes its interaction with the second GC pair of the GCC DNA sequence.	Arginine	28-36	ethylene-responsive transcription factor 13-like	Nicotiana tabacum	75-81
23564481-1	2013	Previous studies regarding the association of p53 codon 72 Arg/Pro polymorphism with hepatocellular carcinoma (HCC) risk have provided conflicting and inconclusive findings.	Arginine	59-62	tumor protein p53	Homo sapiens	46-49
23564481-4	2013	The strength of the association of p53 codon 72 Arg/Pro polymorphism with HCC risk was estimated by the pooled odds ratio (OR) with its corresponding 95 % confidence interval (95 % CI).	Arginine	48-51	tumor protein p53	Homo sapiens	35-38
23564481-9	2013	This meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism may play a critical role in the development of HCC, and gender and family history of HCC may not modulate the effect of p53 codon 72 Arg/Pro in HCC risk.	Arginine	50-53	tumor protein p53	Homo sapiens	37-40
23741493-3	2013	Glycation of lipid-free apoA-I by methylglyoxal and glycolaldehyde resulted in Arg, Lys and Trp loss, advanced glycation end-product formation and protein cross-linking.	Arginine	79-82	apolipoprotein A1	Homo sapiens	24-30
23720861-16	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	fibrinogen beta chain	Homo sapiens	44-54
23617808-5	2013	Our NMR data, combined with precipitation assays, show that there are additional SNARE complex/synaptotagmin-1 interactions that lead to aggregation and that involve in part two arginines at the bottom of the C2B domain.	Arginine	178-187	small NF90 (ILF3) associated RNA E	Homo sapiens	81-86
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Arginine	115-123	lysine demethylase 4B	Homo sapiens	21-26
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Arginine	115-123	lysine demethylase 4B	Homo sapiens	175-180
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Arginine	115-123	lysine demethylase 4B	Homo sapiens	175-180
23718875-1	2013	BACKGROUND: Our prior study revealed the loss in short-term L-Arginine (ARG) therapeutic efficacy after continuous exposure; resulting in tolerance development, mediated by endothelial nitric oxide synthase (eNOS) down-regulation, secondary to oxidative stress and induced glucose accumulation.	Arginine	60-70	nitric oxide synthase 3	Homo sapiens	173-206
23718875-1	2013	BACKGROUND: Our prior study revealed the loss in short-term L-Arginine (ARG) therapeutic efficacy after continuous exposure; resulting in tolerance development, mediated by endothelial nitric oxide synthase (eNOS) down-regulation, secondary to oxidative stress and induced glucose accumulation.	Arginine	72-75	nitric oxide synthase 3	Homo sapiens	173-206
23244702-7	2013	We found that the treatment of Shunt lambs with L-arginine prevented the ADMA-mediated mitochondrial redistribution of eNOS, the nitration-mediated inhibition of CrAT, and maintained carnitine homeostasis.	Arginine	48-58	nitric oxide synthase, endothelial	Ovis aries	119-123
23452237-1	2013	The Tat (twin-arginine translocation) system is a protein targeting pathway utilized by prokaryotes and chloroplasts.	Arginine	14-22	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	4-7
23691096-4	2013	METHODS AND RESULTS: We analyzed the amino acid sequence of P2X7 for any potential trafficking signals and found that P2X7 contains putative Arg-X-Arg ER retention sequences.	Arginine	141-144	purinergic receptor P2X 7	Homo sapiens	118-122
23244702-7	2013	We found that the treatment of Shunt lambs with L-arginine prevented the ADMA-mediated mitochondrial redistribution of eNOS, the nitration-mediated inhibition of CrAT, and maintained carnitine homeostasis.	Arginine	48-58	carnitine O-acetyltransferase	Ovis aries	162-166
23527953-2	2013	Here, we design a nonviral siRNA gene carrier using a combination of an arginine-grafted bioreducible polymer (ABP), microbubbles (MB), and ultrasound (US), for targeting vascular endothelial growth factor (VEGF) in a human ovarian cancer cell line.	Arginine	72-80	vascular endothelial growth factor A	Homo sapiens	171-205
23663243-1	2013	BACKGROUND: Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with the ability of the gene to induce cell apoptosis.	Arginine	22-25	tumor protein p53	Homo sapiens	100-103
23661003-6	2013	We also find that oligomeric Abeta activates FoxO3a by MST1 phosphorylation and arginine methylation in primary cultures of hippocampal and cortical neurons.	Arginine	80-88	forkhead box O3	Homo sapiens	45-51
23527953-2	2013	Here, we design a nonviral siRNA gene carrier using a combination of an arginine-grafted bioreducible polymer (ABP), microbubbles (MB), and ultrasound (US), for targeting vascular endothelial growth factor (VEGF) in a human ovarian cancer cell line.	Arginine	72-80	vascular endothelial growth factor A	Homo sapiens	207-211
23486913-0	2013	Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	0-8	mechanistic target of rapamycin kinase	Sus scrofa	100-104
23642268-7	2013	Three identified proteins: splicing factor, proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences.	Arginine	214-222	splicing factor proline and glutamine rich	Homo sapiens	27-71
23642268-7	2013	Three identified proteins: splicing factor, proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences.	Arginine	214-222	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	80-126
23642268-7	2013	Three identified proteins: splicing factor, proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences.	Arginine	214-222	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	128-136
23486913-10	2013	Collectively, these results indicate that Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	42-45	mechanistic target of rapamycin kinase	Sus scrofa	143-147
23507581-0	2013	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	Arginine	50-58	calmodulin 1	Homo sapiens	127-137
23658699-0	2013	Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetes.	Arginine	35-45	insulin	Homo sapiens	0-7
23658699-2	2013	Given that cardiovascular diseases are also associated with insulin resistance, and insulin is known to induce vasodilation via a NO-dependent pathway, we hypothesised that abnormal insulin modulation of L-arginine transport may contribute to vascular dysfunction in diabetes.	Arginine	204-214	insulin	Homo sapiens	84-91
23658699-2	2013	Given that cardiovascular diseases are also associated with insulin resistance, and insulin is known to induce vasodilation via a NO-dependent pathway, we hypothesised that abnormal insulin modulation of L-arginine transport may contribute to vascular dysfunction in diabetes.	Arginine	204-214	insulin	Homo sapiens	84-91
23658699-5	2013	The effect of locally delivered insulin on arginine transport was assessed during an intra-arterial infusion of [4,5-(3)H] L-arginine.	Arginine	43-51	insulin	Homo sapiens	32-39
23658699-9	2013	CONCLUSION: These findings suggest that insulin resistance may contribute substantially to the onset and development of cardiovascular disease in type 2 diabetics via abnormal insulin-mediated regulation of L-arginine transport.	Arginine	207-217	insulin	Homo sapiens	40-47
23507581-5	2013	To characterize the interaction between the homologous Arg of rat nNOS (R753) and murine iNOS (R530) with CaM, the Arg was mutated to Ala and, in iNOS, to Glu.	Arginine	55-58	calmodulin 1	Homo sapiens	106-109
23507581-10	2013	Our data show that this Arg residue plays an important role in CaM binding and influences FMN binding.	Arginine	24-27	calmodulin 1	Homo sapiens	63-66
23528298-6	2013	The study showed that the homosulfonamide fragment of 8a inserted deep inside the 2 -pocket of the COX-2 active site, where the SO2NH2 group underwent H-bonding interaction with Gln(192)(2.95 A), Phe(518)(2.82 A) and Arg(513)(2.63 and 2.73 A).	Arginine	217-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
22748943-7	2013	In addition, plasma interleukin-6 was significantly decreased by arginine and/or L-NAME treatment, and plasma prostaglandin E2 was significantly decreased by arginine plus L-NAME treatment.	Arginine	65-73	interleukin 6	Rattus norvegicus	20-33
23503772-2	2013	Three apoE isoforms (E4, E3, and E2) are the result of cysteine-arginine interchanges at two sites: there are zero interchanges in E4, one interchange in E3, and two interchanges in E2.	Arginine	64-72	apolipoprotein E	Homo sapiens	6-10
23525231-4	2013	HELZ2 interacts with the serine/arginine-rich domain and Bcl2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2.	Arginine	32-40	helicase with zinc finger 2, transcriptional coactivator	Mus musculus	0-5
23639512-3	2013	The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p53-R72).	Arginine	172-180	tumor protein p53	Homo sapiens	14-17
23639512-3	2013	The wild-type p53 codon has two common polymorphic variants from a single-base-pair substitution at codon 72, where either C-C-C encodes proline (p53-p72) or C-G-C encodes arginine (p53-R72).	Arginine	172-180	DEAD-box helicase 17	Homo sapiens	150-153
23778535-3	2013	Btf and TRAP150 are serine-arginine-rich (SR) proteins with significant sequence similarity, but the extent of their functional overlap is not yet clear.	Arginine	27-35	thyroid hormone receptor associated protein 3	Homo sapiens	8-15
23499006-3	2013	Here, we show that the natural C-terminal fragments of Tau, TDP43, and alpha-synuclein are short-lived substrates of the Arg/N-end rule pathway, a processive proteolytic system that targets proteins bearing "destabilizing" N-terminal residues.	Arginine	121-124	TAR DNA binding protein	Mus musculus	60-65
23571759-6	2013	We identify lysine 301 as the major conjugation site and demonstrate that its replacement with arginine completely abolishes Lif1 SUMOylation in vivo and in vitro.	Arginine	95-103	Lif1p	Saccharomyces cerevisiae S288C	125-129
23726607-6	2013	The intensity of TNF-alpha and IFN-gamma in ARG (144.47 +- 81.21 and 116.61 +- 53.89, respectively) was significant higher than STA (P &lt; .001).	Arginine	44-47	tumor necrosis factor	Homo sapiens	17-26
23726607-6	2013	The intensity of TNF-alpha and IFN-gamma in ARG (144.47 +- 81.21 and 116.61 +- 53.89, respectively) was significant higher than STA (P &lt; .001).	Arginine	44-47	interferon gamma	Homo sapiens	31-40
23726607-8	2013	The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma.	Arginine	41-44	tumor necrosis factor	Homo sapiens	241-250
23726607-8	2013	The intensity in noncultured plasma from ARG or STA was significant lower than that in culture supernates from ARG and STA with sensitivity and specificity to predict acute rejection episodes of 63.6% and 73.3%, respectively, when combining TNF-alpha and IFN-gamma.	Arginine	41-44	interferon gamma	Homo sapiens	255-264
23499006-4	2013	Furthermore, a natural TDP43 fragment is shown to be metabolically stabilized in Ate1(-/-) fibroblasts that lack the arginylation branch of the Arg/N-end rule pathway, leading to accumulation and aggregation of this fragment.	Arginine	144-147	TAR DNA binding protein	Mus musculus	23-28
23499006-6	2013	The discovery that neurodegeneration-associated natural fragments of TDP43, Tau, alpha-synuclein, and APP can be selectively destroyed by the Arg/N-end rule pathway suggests that this pathway counteracts neurodegeneration.	Arginine	142-145	TAR DNA binding protein	Mus musculus	69-74
23620769-4	2013	FUS belongs to the family of TET proteins, which are regulated at the post-translational level by arginine methylation.	Arginine	98-106	FUS RNA binding protein	Homo sapiens	0-3
23620769-5	2013	Here, we investigated the impact of arginine methylation in the pathogenesis of FUS-related ALS.	Arginine	36-44	FUS RNA binding protein	Homo sapiens	80-83
23620769-11	2013	These results support a role for arginine methylation in the pathogenesis of FUS-related ALS.	Arginine	33-41	fusilli	Drosophila melanogaster	77-80
23521535-10	2013	When this residue (arginine) is engineered into the MyT1-F2F3 sequence, the affinity for beta-RAR DNA increases.	Arginine	19-27	myelin transcription factor 1	Homo sapiens	52-61
23554347-7	2013	However, although a substrate-attached synthetic arginine-glycine-aspartic acid (RGD) peptide alone was able to promote the attachment and spreading of fibroblasts, it was inactive for hES cells, indicating that stem cells have different requirements in order to attach and spread on the central fibronectin RGD-cell-binding domain.	Arginine	49-57	fibronectin 1	Homo sapiens	296-307
23559011-7	2013	We also found lysine residue 195 (K195) to be essential for c-FLIP(L) ubiquitination and proteolysis, as mutant c-FLIP(L) lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia.	Arginine	133-141	CASP8 and FADD like apoptosis regulator	Homo sapiens	60-66
23559011-7	2013	We also found lysine residue 195 (K195) to be essential for c-FLIP(L) ubiquitination and proteolysis, as mutant c-FLIP(L) lysine 195 arginine (arginine replacing lysine) was left virtually un-ubiquitinated and was refractory to hyperthermia-triggered degradation, and thus partially blocked the synergistic effect of Mapa and hyperthermia.	Arginine	133-141	CASP8 and FADD like apoptosis regulator	Homo sapiens	112-118
23517305-11	2013	The most likely site of the short H-bond in complexes of thrombin with the hirudin family of inhibitors is in the hydrophobic patch of the C-terminus of hirudin where Glu(57") and Glu(58") are embedded and interact with Arg(75) and Arg(77) and their solvate water (on thrombin).	Arginine	220-223	coagulation factor II, thrombin	Homo sapiens	57-65
23517305-11	2013	The most likely site of the short H-bond in complexes of thrombin with the hirudin family of inhibitors is in the hydrophobic patch of the C-terminus of hirudin where Glu(57") and Glu(58") are embedded and interact with Arg(75) and Arg(77) and their solvate water (on thrombin).	Arginine	220-223	coagulation factor II, thrombin	Homo sapiens	268-276
23517305-11	2013	The most likely site of the short H-bond in complexes of thrombin with the hirudin family of inhibitors is in the hydrophobic patch of the C-terminus of hirudin where Glu(57") and Glu(58") are embedded and interact with Arg(75) and Arg(77) and their solvate water (on thrombin).	Arginine	232-235	coagulation factor II, thrombin	Homo sapiens	57-65
23593250-8	2013	Docking analysis of the interaction of BPs in the ligand-binding pocket of ERalpha suggests that the minimum structural requirement for the estrogenic activity of BPs is a hydroxyl (OH) group in the phenyl A-ring that allows interaction with Glu-353, Arg-394 or Phe-404, which enhances the stability between BPs and ERalpha.	Arginine	251-254	estrogen receptor 1	Homo sapiens	75-82
23522190-5	2013	The frequency of p53 protein degradation was also much higher in HPV 16/18 E6-positive/Arg/Arg lung tumors than in the other 3 groups.	Arginine	87-90	tumor protein p53	Homo sapiens	17-20
23423487-5	2013	However, the TP53 codon 72 polymorphism had a prominent correlation with clinical outcome of patients receiving 5-fluorouracil (5-Fu)-based postoperative chemotherapy [Arg/Arg + Arg/Pro vs. Pro/Pro, adjusted hazard ratio (HR) = 1.63, 95 % confidence interval (CI) = 1.08-2.44].	Arginine	168-171	tumor protein p53	Homo sapiens	13-17
23313574-7	2013	Fibronectin was cleaved into distinct fragments by all three gingipains; however, only arginine-specific HRgpA and RgpB but not lysine-specific Kgp destroyed its cell-spreading activity.	Arginine	87-95	fibronectin 1	Homo sapiens	0-11
23423487-5	2013	However, the TP53 codon 72 polymorphism had a prominent correlation with clinical outcome of patients receiving 5-fluorouracil (5-Fu)-based postoperative chemotherapy [Arg/Arg + Arg/Pro vs. Pro/Pro, adjusted hazard ratio (HR) = 1.63, 95 % confidence interval (CI) = 1.08-2.44].	Arginine	172-175	tumor protein p53	Homo sapiens	13-17
23423487-5	2013	However, the TP53 codon 72 polymorphism had a prominent correlation with clinical outcome of patients receiving 5-fluorouracil (5-Fu)-based postoperative chemotherapy [Arg/Arg + Arg/Pro vs. Pro/Pro, adjusted hazard ratio (HR) = 1.63, 95 % confidence interval (CI) = 1.08-2.44].	Arginine	172-175	tumor protein p53	Homo sapiens	13-17
23557559-14	2013	No p53 gene mutation was detected on the exon 4 - 9, and Pro/Arg SNPs on p53 codon 72 were detected in the cutaneous NK/T-cell lymphoma.	Arginine	61-64	tumor protein p53	Homo sapiens	73-76
23325127-5	2013	The base substitutions change a glycine to arginine in the fibronectin type 3 domain of nephrin and a proline to arginine in a conserved proline-rich region in Neph3.	Arginine	113-121	kirre like nephrin family adhesion molecule 2	Homo sapiens	160-165
23441062-1	2013	SUMMARY: Nitric oxide synthase (NOS) is a critical enzyme for the production of the messenger molecule nitric oxide (NO) from L-arginine.	Arginine	126-136	nitric oxide synthase 2	Homo sapiens	9-30
22732180-11	2013	In a group of patients treated with L-arginine, negative correlation between a change of insulin sensitivity value and a change of PAI 1 concentration was found.	Arginine	36-46	insulin	Homo sapiens	89-96
23530136-7	2013	In addition, A3-613X unmasked a threefold decrease in apparent cGMP affinity with PIP(n) application to homomeric channels, and this effect was dependent on conserved arginines within the N-terminal region of A3.	Arginine	167-176	prolactin induced protein	Homo sapiens	82-85
23521792-3	2013	Here, we show that the Arg-Gly-Gly domain in the C-terminal region of TLS forms a ternary complex with human telomere G-quadruplex DNA and TERRA in vitro.	Arginine	23-26	FUS RNA binding protein	Homo sapiens	70-73
23438481-2	2013	Micromolar concentration of ADMA and NMMA can compete with arginine for nitric oxide synthase (NOS) reducing nitric oxide (NO) formation, whereas SDMA does not.	Arginine	59-67	nitric oxide synthase 2	Homo sapiens	72-93
23362144-0	2013	Functional polymorphisms affecting the clinically important arginine-137 residue of AVPR2 do not influence serum sodium concentration at the population level.	Arginine	60-68	arginine vasopressin receptor 2	Homo sapiens	84-89
23265743-0	2013	Molecular defect of "Prothrombin Amrita": substitution of arginine by glutamine (Arg553 to Gln) near the Na(+) binding loop of prothrombin.	Arginine	58-66	coagulation factor II, thrombin	Homo sapiens	21-32
23335559-6	2013	Mutation of Lys-5-57 to arginines prevented binding of the VCP-UBXD1 complex and, importantly, strongly reduced recruitment of VCP-UBXD1 to endocytic compartments.	Arginine	24-33	UBX domain protein 6	Homo sapiens	63-68
23335559-6	2013	Mutation of Lys-5-57 to arginines prevented binding of the VCP-UBXD1 complex and, importantly, strongly reduced recruitment of VCP-UBXD1 to endocytic compartments.	Arginine	24-33	UBX domain protein 6	Homo sapiens	131-136
23372161-10	2013	We constructed a series of mutants by replacing single or double Arg residues in the corin propeptide and identified Arg-530 in the Fz2 domain as the alternative autocleavage site.	Arginine	65-68	corin, serine peptidase	Homo sapiens	85-90
23372161-10	2013	We constructed a series of mutants by replacing single or double Arg residues in the corin propeptide and identified Arg-530 in the Fz2 domain as the alternative autocleavage site.	Arginine	117-120	corin, serine peptidase	Homo sapiens	85-90
23467560-7	2013	In vitro studies showed that amino acids such as cysteine, histidine, arginine, and lysine, as well as other nucleophiles such as taurine, inhibited cyanate-induced C-Alb formation at physiologic pH and temperature.	Arginine	70-78	albumin	Homo sapiens	167-170
23233327-6	2013	The role of individual CRT arginine residues was determined by site-directed mutagenesis, and nitric oxide levels were measured using a fluorochrome-based assay.	Arginine	27-35	calreticulin	Homo sapiens	23-26
23233327-10	2013	Site-directed mutation analysis identified Arg(205), which is spatially adjacent to the SE binding site in the CRT P-domain, as a dominant inhibitor of SE-CRT interaction and signaling, while a more remote arginine residue, Arg(261), was found to enhance these SE functions.	Arginine	43-46	calreticulin	Homo sapiens	111-114
23233327-10	2013	Site-directed mutation analysis identified Arg(205), which is spatially adjacent to the SE binding site in the CRT P-domain, as a dominant inhibitor of SE-CRT interaction and signaling, while a more remote arginine residue, Arg(261), was found to enhance these SE functions.	Arginine	43-46	calreticulin	Homo sapiens	155-158
23433851-0	2013	Arginine homozygosity in codon 72 of p53 correlates with failure to imatinib response in chronic myeloid leukemia.	Arginine	0-8	tumor protein p53	Homo sapiens	37-40
23265743-0	2013	Molecular defect of "Prothrombin Amrita": substitution of arginine by glutamine (Arg553 to Gln) near the Na(+) binding loop of prothrombin.	Arginine	58-66	coagulation factor II, thrombin	Homo sapiens	127-138
22527286-6	2013	The anti-inflammatory effects of arginine and glutamine were associated with decreased activation levels of signaling molecules known to be involved in mast cell cytokine expression such as MAPK family members extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, and the protein kinase B (Akt).	Arginine	33-41	mitogen-activated protein kinase 14	Homo sapiens	278-281
22527286-6	2013	The anti-inflammatory effects of arginine and glutamine were associated with decreased activation levels of signaling molecules known to be involved in mast cell cytokine expression such as MAPK family members extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, and the protein kinase B (Akt).	Arginine	33-41	AKT serine/threonine kinase 1	Homo sapiens	309-312
23111882-13	2013	The results suggest that L-arginine and GSNO-mediated NO leads to the inhibition of key apoptotic processes including caspase-3 activation, PS exposure and low mitochondrial membrane potential in washed platelets.	Arginine	25-35	caspase 3	Homo sapiens	118-127
23184052-7	2013	Subgroup analyses by ethnicity showed that TP53 Arg72Pro polymorphism contributed to bladder cancer risk in East Asians in three genetic models (For Pro vs. Arg, Fixed-effects OR 1.18, 95 % CI 1.05-1.32; For ProPro vs. ArgArg, Fixed-effects OR 1.40, 95 % CI 1.11-1.77; For ProPro vs. ArgPro/ArgArg, Fixed-effects OR 1.32, 95 % CI 1.07-1.62).	Arginine	48-51	tumor protein p53	Homo sapiens	43-47
23415437-4	2013	APOA-I gene sequencing revealed a novel heterozygous in-frame insertion mutation with duplication of nucleotides 1535 through 1552 inserted at position 1553, causing a new amino acid glycine at codon 157 and a duplication of amino acids alanine, arginine, alanine, histidine, and leucine at codons 158-162.	Arginine	246-254	apolipoprotein A1	Homo sapiens	0-6
23068452-7	2013	Rs1047286 is in strong linkage disequilibrium with Rs2230199 (C3 Arg102Gly), of which the Arg/Arg genotype was associated with higher CSF levels of C3 and lower levels of C5a and terminal complement complex (TCC; soluble C5b-9), indicating decreased consumption of C3 and less activation of the complement system.	Arginine	65-68	complement C5a receptor 1	Homo sapiens	171-174
23068452-7	2013	Rs1047286 is in strong linkage disequilibrium with Rs2230199 (C3 Arg102Gly), of which the Arg/Arg genotype was associated with higher CSF levels of C3 and lower levels of C5a and terminal complement complex (TCC; soluble C5b-9), indicating decreased consumption of C3 and less activation of the complement system.	Arginine	90-93	complement C5a receptor 1	Homo sapiens	171-174
23269800-4	2013	Based on arginine-rich features and adaptive evolution characteristics of vertebrate defensins, we conducted a screen for HD5 derivatives with enhanced anti-HSV-2 activity by a single arginine substitution at the adaptive evolution sites.	Arginine	9-17	defensin alpha 5	Homo sapiens	122-125
23269800-4	2013	Based on arginine-rich features and adaptive evolution characteristics of vertebrate defensins, we conducted a screen for HD5 derivatives with enhanced anti-HSV-2 activity by a single arginine substitution at the adaptive evolution sites.	Arginine	184-192	defensin alpha 5	Homo sapiens	122-125
23269800-9	2013	This study demonstrates that arginine mutagenesis at appropriate evolution sites may significantly enhance the antiviral activity of HD5, which also paves a facile way to search for potent antiviral drugs based on natural antimicrobial peptides.	Arginine	29-37	defensin alpha 5	Homo sapiens	133-136
23278594-3	2013	Whether protein arginine methylation affects B cell division and/or isotype switching to IgG1 in response to LPS, IL-4, and CD40-L was examined using the arginine methyl transferase inhibitor adenosine-2",3"-dialdehyde (AdOx).	Arginine	16-24	CD40 ligand	Homo sapiens	124-130
23278594-7	2013	Taken together, arginine methylation appears to be involved in B cell isotype switching, as well as in clonal expansion of B cells in response to LPS/IL-4/CD40-L.	Arginine	16-24	interleukin 4	Homo sapiens	150-154
23278594-7	2013	Taken together, arginine methylation appears to be involved in B cell isotype switching, as well as in clonal expansion of B cells in response to LPS/IL-4/CD40-L.	Arginine	16-24	CD40 ligand	Homo sapiens	155-161
23192612-1	2013	Among many alterations within the TP53 gene the rs1042522 (C72G, p.Pro72Arg) has been associated with numerous cancers , however the results differ between populations for opposite Pro or Arg alleles.	Arginine	72-75	tumor protein p53	Homo sapiens	34-38
23321422-0	2013	The Arabidopsis TUMOR PRONE5 gene encodes an acetylornithine aminotransferase required for arginine biosynthesis and root meristem maintenance in blue light.	Arginine	91-99	HOPW1-1-interacting 1	Arabidopsis thaliana	16-28
23358825-5	2013	The remodeling function is mediated by a bipartite Gly-Arg rich domain of EBNA1 that resembles the AT-hook of High Mobility Group A (HMGA) architectural transcription factors.	Arginine	55-58	EBNA-1	Human gammaherpesvirus 4	74-79
23321422-3	2013	We report the cloning and characterization of the TUMOR PRONE5 (TUP5) gene of Arabidopsis (Arabidopsis thaliana) encoding an acetylornithine aminotransferase (ACOAT), catalyzing the fourth step of arginine biosynthesis.	Arginine	197-205	HOPW1-1-interacting 1	Arabidopsis thaliana	50-62
23321422-3	2013	We report the cloning and characterization of the TUMOR PRONE5 (TUP5) gene of Arabidopsis (Arabidopsis thaliana) encoding an acetylornithine aminotransferase (ACOAT), catalyzing the fourth step of arginine biosynthesis.	Arginine	197-205	HOPW1-1-interacting 1	Arabidopsis thaliana	64-68
23321422-4	2013	The free arginine content was strongly reduced in the chemically induced recessive mutant tup5-1, root growth was restored by supplementation with arginine and its metabolic precursors, and a yeast (Saccharomyces cerevisiae) ACOAT mutant was complemented by TUP5.	Arginine	9-17	HOPW1-1-interacting 1	Arabidopsis thaliana	90-94
23321422-4	2013	The free arginine content was strongly reduced in the chemically induced recessive mutant tup5-1, root growth was restored by supplementation with arginine and its metabolic precursors, and a yeast (Saccharomyces cerevisiae) ACOAT mutant was complemented by TUP5.	Arginine	9-17	HOPW1-1-interacting 1	Arabidopsis thaliana	258-262
23321422-4	2013	The free arginine content was strongly reduced in the chemically induced recessive mutant tup5-1, root growth was restored by supplementation with arginine and its metabolic precursors, and a yeast (Saccharomyces cerevisiae) ACOAT mutant was complemented by TUP5.	Arginine	147-155	HOPW1-1-interacting 1	Arabidopsis thaliana	90-94
23321422-5	2013	Two null alleles of TUP5 caused a reduced viability of gametes and embryo lethality, possibly caused by insufficient Arg supply from maternal tissue.	Arginine	117-120	HOPW1-1-interacting 1	Arabidopsis thaliana	20-24
23266819-5	2013	The substitution of arginine for cysteine eliminates several hydrogen bonds and reduces the van der Waals interaction between HSD10 subunits.	Arginine	20-28	fibrous sheath interacting protein 1	Homo sapiens	126-131
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Arginine	109-112	kininogen 1	Homo sapiens	73-83
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Arginine	165-168	kininogen 1	Homo sapiens	73-83
23374218-5	2013	Using a UV-vis spectrophotometer, the method enables the detection of arginine in the range of 0.08-13.2 muM with a detection limit (3sigma/slope) of 16 nM.	Arginine	70-78	latexin	Homo sapiens	105-108
23374218-6	2013	Particularly, as low as 0.4 muM arginine can be easily detected by the naked eye without using any complicated or expensive instruments.	Arginine	32-40	latexin	Homo sapiens	28-31
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	38-41	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
23138654-6	2013	The effects of arginine on the thermal stability and size of lysozyme and ovalbumin are measured over a wide concentration range (0 to 2 M), and we find that the formation of protein-associated Arg(+) clusters consistently explains the complex effects of arginine on protein stability and size.	Arginine	15-23	lysozyme	Homo sapiens	61-69
23138654-6	2013	The effects of arginine on the thermal stability and size of lysozyme and ovalbumin are measured over a wide concentration range (0 to 2 M), and we find that the formation of protein-associated Arg(+) clusters consistently explains the complex effects of arginine on protein stability and size.	Arginine	194-197	lysozyme	Homo sapiens	61-69
23358683-2	2013	Besides proteinogenic amino acids also the guanidiniocarbonyl pyrrole cation (abbreviated as GCP), as an artificial arginine analog, was introduced into the arms of the ligands to investigate its influence on protein surface binding and enzyme inhibition.	Arginine	116-124	golgin B1	Homo sapiens	93-96
23255592-3	2013	In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg.	Arginine	231-236	interleukin 1 beta	Homo sapiens	36-53
23255592-3	2013	In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg.	Arginine	231-236	interferon gamma	Homo sapiens	58-74
23255592-3	2013	In inflamed HLMVEC (pretreated with interleukin-1beta and interferon-gamma), we found enhanced binding of eNOS to calcium-calmodulin at basal Ca(2+) levels, thereby increasing its basal activity that was dependent on extracellular l-Arg.	Arginine	231-236	nitric oxide synthase 3	Homo sapiens	106-110
23356331-1	2013	Human leukocyte antigen (HLA)-A*02:357 differs from A*02:01:01:01 by a single nucleotide at position 840 from A to T exon 4, leading to amino acid substitution from Arg to Ser.	Arginine	165-168	major histocompatibility complex, class I, A	Homo sapiens	0-31
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	38-41	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	38-41	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	20-24
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23264629-4	2013	Among the recurrent IDH2 mutations at Arg-172 and Arg-140, IDH2 Arg-172 mutations consistently led to greater 2HG accumulation than IDH2 Arg-140 mutations, and the degree of 2HG accumulation correlated with the ability of these mutations to block cellular differentiation.	Arginine	50-53	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	59-63
23245845-6	2013	Treatments of cytokine IL-4 and/or IL-13 to ATMs reduced iNOS expression but increased Arg-I expression which were exacerbated when treated with T cell- and adipocyte-conditioned medium.	Arginine	87-90	interleukin 4	Homo sapiens	23-27
22870827-1	2013	The cellular uptake of L-arginine and other cationic amino acids (such as L-lysine and L-ornithine) is mainly mediated by cationic amino acid transporter (CAT) proteins.	Arginine	23-33	catalase	Homo sapiens	155-158
23245845-6	2013	Treatments of cytokine IL-4 and/or IL-13 to ATMs reduced iNOS expression but increased Arg-I expression which were exacerbated when treated with T cell- and adipocyte-conditioned medium.	Arginine	87-90	interleukin 13	Homo sapiens	35-40
23245845-8	2013	This study was the first to show the effect of IL-4 and IL-13 on collagen formation, through iNOS and Arg-I expressions, that was exacerbated in a condition that mimics in vivo condition of active lesions.	Arginine	102-105	interleukin 4	Homo sapiens	47-51
23245845-8	2013	This study was the first to show the effect of IL-4 and IL-13 on collagen formation, through iNOS and Arg-I expressions, that was exacerbated in a condition that mimics in vivo condition of active lesions.	Arginine	102-105	interleukin 13	Homo sapiens	56-61
23172304-3	2013	Mutations at the P1 (Arg(15)) site in combination with P2" (Met(17)) mutations profoundly affect inhibition of FXIa, plasmin, kallikrein, factor Xa and thrombin.	Arginine	21-24	coagulation factor II	Mus musculus	152-160
23258564-5	2013	Additionally, HFI could easily precipitate and had progressive characteristics and thus, the buffer system of the additive phosphate-citric acid buffer, arginine, Triton X-100 or Tween-80, the establishment of a microfiltration, ion exchange, affinity chromatography and gel filtration chromatography-based purification process were explored.	Arginine	153-161	major intrinsic protein of lens fiber	Mus musculus	14-17
23365131-10	2013	Molecular analysis revealed that ovarian tumor cells harbored the Arg 201 activating mutation in the GNAS1 gene.	Arginine	66-69	GNAS complex locus	Homo sapiens	101-106
23192640-1	2013	The genetic polymorphism of p53 codon 72 Arg/Pro has been implicated in oral cancer risk, but the results of previous studies remain controversial and ambiguous.	Arginine	41-44	tumor protein p53	Homo sapiens	28-31
23204298-2	2013	An arginine-to-cysteine polymorphism at position 92 of colipase (Arg92Cys) associates with an increased risk for developing type-2 diabetes through an undefined mechanism.	Arginine	3-11	colipase	Homo sapiens	55-63
23040413-1	2013	OBJECTIVE: The aim of this study was to evaluate the effects of a new L-arginine-enriched biscuit on endothelial function, insulin sensitivity/secretion and body composition.	Arginine	70-80	insulin	Homo sapiens	123-130
23040413-11	2013	In the second study, the L-arginine-enriched biscuit recipient group displayed increased L-arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group.	Arginine	25-35	insulin	Homo sapiens	180-190
23040413-11	2013	In the second study, the L-arginine-enriched biscuit recipient group displayed increased L-arginine, NOx, cGMP, PI-BF, and Matsuda index levels, whereas their circulating glucose, proinsulin/insulin ratio and fat mass were decreased compared with the placebo biscuit recipient group.	Arginine	25-35	insulin	Homo sapiens	183-190
23040413-12	2013	CONCLUSIONS: L-Arginine-enriched biscuits with low sugar and protein content enhance endothelial function and improve glucose metabolism, insulin sensitivity and insulin secretion in subjects with IGT and MS.	Arginine	13-23	insulin	Homo sapiens	138-145
23180246-0	2013	TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation.	Arginine	98-106	TNF superfamily member 10	Homo sapiens	0-5
23180246-8	2013	Inhibitors for caspase-3, 6, 9, and 10 were able to block the cleavage of these two autophagic proteins to some extent and correspondingly rescue cells from the cytotoxicity of the combination of TRAIL and arginine deprivation.	Arginine	206-214	caspase 3	Homo sapiens	15-30
23155057-5	2013	In this work, we prepared various rat alpha1-antitrypsin variants containing Arg at the P1 site within the reactive site loop, and examined their respective selectivity.	Arginine	77-80	serpin family A member 1	Homo sapiens	38-56
23192640-2	2013	To estimate the effect of the p53 codon 72 Arg/Pro polymorphism on the risk of oral cancer, a meta-analysis was performed.	Arginine	43-46	tumor protein p53	Homo sapiens	30-33
23192640-3	2013	Based on a comprehensive search in PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases, we identified all available publications assessing the association between p53 codon 72 Arg/Pro polymorphism and oral cancer risk.	Arginine	217-220	tumor protein p53	Homo sapiens	204-207
23365224-0	2013	Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways.	Arginine	5-8	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	Mus musculus	0-4
23169299-14	2013	CONCLUSION: asparagine-glycine-arginine-hTNF can be safely escalated at doses higher than MTD and induces low receptors shedding and early antivascular effects.	Arginine	31-39	tumor necrosis factor	Homo sapiens	40-44
23233678-7	2013	Our results indicate dual critical roles of the arginine residue at position 26 in apoA-I(Iowa): destabilization of the N-terminal helix bundle structure in full-length protein and enhancement of amyloid fibril formation by the N-terminal 1-83 fragment.	Arginine	48-56	apolipoprotein A1	Homo sapiens	83-95
23166320-5	2013	Neutralization (Arg Ala substitution) of the N-terminal, but not of the C-terminal basic motif, causes the loss of p17 heparin-binding capacity.	Arginine	16-19	family with sequence similarity 72 member B	Homo sapiens	115-118
23234567-3	2013	According to infrared absorption, fibrils from bovine insulin ([BI]) and Lys(B31)-Arg(B32) human insulin analogue ([KR]) cross-seed each other and imprint distinct structural features in daughter fibrils.	Arginine	82-85	insulin	Homo sapiens	97-104
24397513-12	2013	Arginine addition decreased TG, cholesterol and A1-c haemoglobin concentration and increased PPARalpha, PPARgamma and iNOS expression.	Arginine	0-8	peroxisome proliferator activated receptor alpha	Gallus gallus	93-102
24324968-4	2013	The binding analysis suggested that they have a strong mechanistic ability to correct the pathological structural orientation of ApoE4 by preventing repulsion between Arg 61 and Arg 112, thus inhibiting the formation of a salt bridge between Arg 61 and Glu 255.	Arginine	167-170	apolipoprotein E	Homo sapiens	129-134
24324968-4	2013	The binding analysis suggested that they have a strong mechanistic ability to correct the pathological structural orientation of ApoE4 by preventing repulsion between Arg 61 and Arg 112, thus inhibiting the formation of a salt bridge between Arg 61 and Glu 255.	Arginine	178-181	apolipoprotein E	Homo sapiens	129-134
24324968-4	2013	The binding analysis suggested that they have a strong mechanistic ability to correct the pathological structural orientation of ApoE4 by preventing repulsion between Arg 61 and Arg 112, thus inhibiting the formation of a salt bridge between Arg 61 and Glu 255.	Arginine	178-181	apolipoprotein E	Homo sapiens	129-134
23384217-3	2013	Growth hormone (GH) was measured by both spontaneous overnight testing and following arginine/glucagon stimulation administration.	Arginine	85-93	growth hormone 1	Homo sapiens	0-14
23984333-8	2013	The presence of the epitope Bw4 determines a conformational change which leads to a stronger interaction between nonpolymorphic arginine at position 79 of HLA-B and KIR3DL1*001 136-142 loop.	Arginine	128-136	BW4	Homo sapiens	28-31
24397513-12	2013	Arginine addition decreased TG, cholesterol and A1-c haemoglobin concentration and increased PPARalpha, PPARgamma and iNOS expression.	Arginine	0-8	nitric oxide synthase 2	Gallus gallus	118-122
22933436-10	2013	In response to combined arginine and glucose stimulation, maximal insulin response was reduced.	Arginine	24-32	insulin	Homo sapiens	66-73
23164986-3	2013	This review will focus on the eNOS substrate (L-arginine), its cofactor (tetrahydrobiopterin), and mechanisms related to the uncoupling of eNOS activity.	Arginine	46-56	nitric oxide synthase 3	Homo sapiens	30-34
23164986-4	2013	RECENT FINDINGS: The global arginine bioavailability ratio has been proposed as a biomarker reflective of L-arginine availability, arginase activity, and citrulline cycling, as all of these processes impact eNOS activity.	Arginine	28-36	nitric oxide synthase 3	Homo sapiens	207-211
23164986-6	2013	Identification of transporters for biopterin species as well as signals that regulate endogenous arginine production have provided insight for alternative strategies to raise endothelial tetrahydrobiopterin levels while reducing dihydrobiopterin and alter eNOS activity.	Arginine	97-105	nitric oxide synthase 3	Homo sapiens	256-260
23457309-4	2013	A novel missense mutation with a transversion of G to A at position 1462 in exon 12 of the DUOX2 gene that caused a replacement of glycine (G) with arginine (R) at codon 488 of the protein (c.1462G&gt;A, p.[G488R]) was identified.	Arginine	148-156	dual oxidase 2	Homo sapiens	91-96
23210739-3	2013	The frequencies of GG genotype at 309 position in the second promoter (P2) of MDM2 and Arginine in codon72 of p53 were found to be 3.5 (odds ratio [OR]=3.51; 95% confidence interval [CI]=1.93-6.4; p&lt;0.0001) and 5 (OR=4.978; 95% CI=2.7-9.2; p&lt;0.0001) fold higher, respectively, in cases than in the control.	Arginine	87-95	tumor protein p53	Homo sapiens	110-113
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	96-99	tumor protein p53	Homo sapiens	43-46
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	96-99	tumor protein p53	Homo sapiens	92-95
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	100-103	tumor protein p53	Homo sapiens	43-46
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	100-103	tumor protein p53	Homo sapiens	92-95
23210739-5	2013	We found an association of p53 codon72 arginine and MDM2 SNP309 GG genotype with different clinical and histological grades, human papillomavirus (HPV) infection, and age at the time of diagnosis of cervical cancer.	Arginine	39-47	tumor protein p53	Homo sapiens	27-30
23210739-6	2013	In conclusion, Arginine at codon72 of p53 and GG genotype at 309 in P2 of MDM2 together reveal a direct proportionality with the tumor grade of cervical cancer along with HPV infection in postmenopausal women.	Arginine	15-23	tumor protein p53	Homo sapiens	38-41
23041330-13	2013	CONCLUSIONS: Pancreas-specific deletion of IkappaBalpha results in nuclear translocation of RelA and reduces AP induction and trypsin activation in mice after administration of cerulein or L-arginine.	Arginine	189-199	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	43-55
24282631-5	2013	We make use of modeling and docking studies of adenylate kinase (ADK) to reveal the effects produced by the incorporation of the arginine mimetics on the structure of ADK and its action.	Arginine	129-137	adenosine kinase	Homo sapiens	47-63
24282631-5	2013	We make use of modeling and docking studies of adenylate kinase (ADK) to reveal the effects produced by the incorporation of the arginine mimetics on the structure of ADK and its action.	Arginine	129-137	adenosine kinase	Homo sapiens	65-68
24282631-5	2013	We make use of modeling and docking studies of adenylate kinase (ADK) to reveal the effects produced by the incorporation of the arginine mimetics on the structure of ADK and its action.	Arginine	129-137	adenosine kinase	Homo sapiens	167-170
23164225-0	2013	Milk protein responses in dairy cows to changes in postruminal supplies of arginine, isoleucine, and valine.	Arginine	75-83	Weaning weight-maternal milk	Bos taurus	0-4
23991369-2	2013	In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide.	Arginine	155-163	tumor protein p53	Homo sapiens	26-29
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Arginine	4-7	tumor protein p53	Homo sapiens	66-69
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Arginine	8-11	tumor protein p53	Homo sapiens	66-69
23124863-1	2013	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene in association with human papillomavirus (HPV) 16 E6 variants has been implicated as a risk marker in cervical neoplasia.	Arginine	8-11	tumor protein p53	Homo sapiens	66-69
23124863-4	2013	The data obtained showed statistically significant different distribution of p53 genotypes between healthy controls and precursor lesions, with the p53 arginine homozygous increased in high-grade squamous intraepithelial lesions.	Arginine	152-160	tumor protein p53	Homo sapiens	77-80
23124863-4	2013	The data obtained showed statistically significant different distribution of p53 genotypes between healthy controls and precursor lesions, with the p53 arginine homozygous increased in high-grade squamous intraepithelial lesions.	Arginine	152-160	tumor protein p53	Homo sapiens	148-151
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	19-27	tumor protein p53	Homo sapiens	15-18
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	19-27	tumor protein p53	Homo sapiens	181-184
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	185-188	tumor protein p53	Homo sapiens	15-18
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	185-188	tumor protein p53	Homo sapiens	181-184
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	189-192	tumor protein p53	Homo sapiens	15-18
23124863-7	2013	In conclusion, p53 arginine homozygous was found to be increased in high-grade lesions, supporting the results of previous investigations indicating that HPV-positive patients with p53 Arg/Arg have an increased risk of developing pre-cancerous lesions.	Arginine	189-192	tumor protein p53	Homo sapiens	181-184
23124863-8	2013	In addition, T350G HPV 16 variant was over-represented in p53 Arg homozygous women with cervical lesions.	Arginine	62-65	tumor protein p53	Homo sapiens	58-61
23594562-3	2013	SUBJECT AND METHOD: The frequency of HER1 Arg(R) 497Lys (K) and HER2 Ile (I) 655Val (V) polymorphisms were tested in 64 breast cancer patients and 86 normal control by polymerase chain reaction followed by restriction fragment polymorphism detection.	Arginine	42-45	epidermal growth factor receptor	Homo sapiens	37-41
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Arginine	29-32	tumor protein p53	Homo sapiens	87-91
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Arginine	33-36	tumor protein p53	Homo sapiens	87-91
23092908-7	2013	RESULTS: The distribution of Arg/Arg, Arg/Pro and Pro/Pro genotypes of codon 72 of the TP53 gene was: 46.8%, 46.8% and 6.4%, respectively in the ovarian carcinomas and 64.3%, 31.4% and 4.3%, respectively in the control group.	Arginine	33-36	tumor protein p53	Homo sapiens	87-91
23710196-4	2013	Newer evidence suggests that a potential explanation for this paradoxical relationship is related to nitric oxide synthase (NOS) uncoupling, which occurs due to an imbalance between L-arginine (NOS substrate) and its endogenous inhibitor, asymmetric di-methyl arginine (ADMA).	Arginine	182-192	nitric oxide synthase 2	Homo sapiens	101-122
23100584-11	2013	Arginine infusion induced a brief 5 to 15 min increase in plasma concentrations of insulin that was not different in saline- and ACTH-treated foals.	Arginine	0-8	insulin	Homo sapiens	83-90
22889511-7	2013	L-NAME treatment suppressed Arg effects on: 1) nitrite and c-GMP content; 2) glycogen synthesis and glucose uptake; 3) basal and insulin-stimulated p-Akt (Ser(473)), total and p-AMPK-alpha and ACC, and nNOS expression.	Arginine	28-31	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
22504132-5	2013	In the present study, we hypothesized that omega-3 FA emulsion pretreatment would decrease the production of NO in LPS-stimulated macrophages and that this effect would occur through alterations in the cellular uptake of l-arginine and CAT-2 expression, in addition to iNOS expression.	Arginine	221-231	nitric oxide synthase 2, inducible	Mus musculus	269-273
22504132-14	2013	CONCLUSIONS: These experiments demonstrated that, in addition to other anti-inflammatory effects, omega-3 FA lipid emulsion also significantly lowers NO production and l-arginine transport through altered expression of iNOS and CAT-2 in LPS-stimulated RAW264.7 macrophage cells.	Arginine	168-178	nitric oxide synthase 2, inducible	Mus musculus	219-223
23097442-5	2013	Alanine scanning mutagenesis revealed that Lys(97) and Arg(98) in the alpha-helix of the JEV core protein play a crucial role in the interaction with Caprin-1.	Arginine	55-58	cell cycle associated protein 1	Homo sapiens	150-158
22889511-6	2013	RESULTS: Arg-treatment increased: 1) basal and insulin-stimulated glycogen synthesis; 2) glucose uptake; 3) palmitate oxidation; 4) p-Akt (Ser(473)), total and plasma membrane GLUT4 content, total and p-AMPK-alpha and p-ACC (Ser(79)), p-GSK-3alpha/beta (Ser(21/9)) and 5) nitrite and c-GMP levels.	Arginine	9-12	AKT serine/threonine kinase 1	Rattus norvegicus	134-137
22889511-8	2013	CONCLUSION: We provide evidence that Arg improves glucose and lipid metabolism in skeletal muscle, in parallel with increased phosphorylation of Akt and AMPK-alpha.	Arginine	37-40	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
22889511-10	2013	Thus, arginine treatment enhances signal transduction and has a beneficial effect of metabolism in skeletal muscle through direct activation of Akt and AMPK pathways.	Arginine	6-14	AKT serine/threonine kinase 1	Rattus norvegicus	144-147
23122700-3	2013	Arginase-2 competes with eNOS for l-arginine and counteracts the NOS-dependent relaxation in umbilical vessels from normal pregnancies.	Arginine	34-44	nitric oxide synthase 3	Homo sapiens	25-29
24107492-2	2013	L-Arginine, a semi-essential amino acid, is a common substrate for both the arginases and NO synthase (NOS) enzyme families.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	90-101
23085017-13	2013	Interleukin-6, tumor necrosis factor-alpha, and NO production in the macrophages decreased and arginase-1 was upregulated in the ARG-treated rats.	Arginine	129-132	interleukin 6	Rattus norvegicus	0-42
23179835-8	2013	In response to an inflammatory stimulus like LPS, M1 macrophages produce inducible nitric oxide synthase (iNOS) which uses L-arginine as a substrate to produce nitric oxide (NO).	Arginine	123-133	nitric oxide synthase 2, inducible	Mus musculus	73-104
23179835-8	2013	In response to an inflammatory stimulus like LPS, M1 macrophages produce inducible nitric oxide synthase (iNOS) which uses L-arginine as a substrate to produce nitric oxide (NO).	Arginine	123-133	nitric oxide synthase 2, inducible	Mus musculus	106-110
23179835-9	2013	M2 macrophages constitutively produce the enzyme arginase I (argI), which sequesters L-arginine from iNOS and results in the production of ornithine and downstream polyamines and L-proline.	Arginine	85-95	nitric oxide synthase 2, inducible	Mus musculus	101-105
23469172-8	2013	Testing our method on models for the arginine catabolism and the negative feedback loop of the p53 signalling pathway, we found that it estimated the parameters with high accuracy and within a reasonable computation time compared to well-known approaches, including Particle Swarm Optimization, Nelder-Mead, and Firefly Algorithm.	Arginine	37-45	tumor protein p53	Homo sapiens	95-98
24367270-4	2013	We had shown that mutation of arginines R36 and R42 in the F plasmid CBP, SopB, reduces stimulation of SopA-catalyzed ATP hydrolysis without changing SopA-SopB affinity, suggesting the role of hydrolysis could be analyzed using SopA with normal conformational responses to ATP.	Arginine	30-39	CREB binding protein	Homo sapiens	69-72
23126564-1	2013	The single nucleotide polymorphism (SNP) rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein.	Arginine	70-78	solute carrier family 30 (zinc transporter), member 8	Mus musculus	149-167
23483889-13	2013	Taken together, our findings unveil a link between PRMT1 and p38alpha in regulating the erythroid differentiation program and provide evidence suggesting a novel regulatory mechanism for p38alpha through arginine methylation.	Arginine	204-212	mitogen-activated protein kinase 14	Homo sapiens	187-195
23308182-7	2013	Akt sites on Clk1 are in the serine/arginine-rich domain and not the kinase domain.	Arginine	36-44	thymoma viral proto-oncogene 1	Mus musculus	0-3
23126564-1	2013	The single nucleotide polymorphism (SNP) rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein.	Arginine	70-78	solute carrier family 30 (zinc transporter), member 8	Mus musculus	169-173
23285494-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
23832586-6	2013	This review describes the essential role of quantum chemical interactions via the arginine side chain in the mechanism of BACE1 inhibition, and proposes an "electron donor/acceptor bioisostere" concept for medicinal science based on quantum chemical interactions.	Arginine	82-90	beta-secretase 1	Homo sapiens	122-127
23832586-7	2013	Several potent BACE1 inhibitors, as well as the first peptides with BACE1 inhibiting activity were designed and synthesized based on studies of quantum chemical interactions via arginine side chain and the "electron donor bioisostere" concept.	Arginine	178-186	beta-secretase 1	Homo sapiens	15-20
23256225-11	2004	They are also amenable to modification with bulky substituents that interact with the arginine patch or tunnel region on PSMA.	Arginine	86-94	folate hydrolase 1	Homo sapiens	121-125
23263669-1	2012	Nitric oxide (NO) is a free radical and a signaling molecule in several pathways, produced by nitric oxide synthase (NOS) from the conversion of L-arginine to citrulline.	Arginine	145-155	nitric oxide synthase 2	Homo sapiens	94-115
23256224-11	2004	They are also amenable to modification with bulky substituents that interact with the arginine patch or tunnel region on PSMA.	Arginine	86-94	folate hydrolase 1	Homo sapiens	121-125
23099479-7	2012	Indeed, Arg was activated by endothelial stimulation with thrombin, histamine, and vascular endothelial growth factor.	Arginine	8-11	coagulation factor II	Mus musculus	58-66
23267435-2	2012	Almost all described mutations are heterozygous missense mutations affecting a conserved arginine residue in the substrate binding site of IDH1 (R132) or IDH2 (R172).	Arginine	89-97	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	154-158
23462742-7	2013	Moreover, the present study identified Arg as a key CaM interacting residue from Nm/Ng.	Arginine	39-42	calmodulin 1	Homo sapiens	52-55
23043193-10	2012	Individuals with type 2 diabetes had lower insulin sensitivity (-33 +- 11%) and insulin secretory responses to glucose, GLP-1, and arginine (-40 +- 11, -58 +- 7, and -36 +- 13%, respectively) and higher plasma glucagon and endogenous glucose production compared with normal glucose-tolerant subjects (all P &lt; 0.05).	Arginine	131-139	insulin	Homo sapiens	80-87
23399839-6	2012	L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK zeta chain and the NK-92 intracellular production of IFN-gamma.	Arginine	0-5	interferon gamma	Homo sapiens	161-170
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	84-87	insulin	Homo sapiens	50-57
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	84-87	insulin	Homo sapiens	104-111
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	84-87	insulin	Homo sapiens	104-111
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	94-97	insulin	Homo sapiens	50-57
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	94-97	insulin	Homo sapiens	104-111
23093664-1	2012	OBJECTIVE: In vivo, after subcutaneous injection, insulin glargine (21(A)-Gly-31(B)-Arg-32(B)-Arg-human insulin) is enzymatically processed into 21(A)-Gly-human insulin (metabolite 1 [M1]).	Arginine	94-97	insulin	Homo sapiens	104-111
23897115-1	2012	L-arginine is the common substrate for arginase and nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	52-73
22965295-11	2012	Isolated islets and alpha (but not beta) cell fractions released GLP-1, which was regulated by glucose and arginine.	Arginine	107-115	glucagon	Homo sapiens	65-70
23032699-0	2012	Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation.	Arginine	30-38	protein arginine methyltransferase 6	Homo sapiens	15-20
23032699-0	2012	Suppression of PRMT6-mediated arginine methylation of p16 protein potentiates its ability to arrest A549 cell proliferation.	Arginine	30-38	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-57
23032699-4	2012	We then determined that the arginine 22, 131 and 138 of p16 were the main methylation sites.	Arginine	28-36	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-59
23032699-6	2012	Furthermore, co-immunoprecipitation assays suggested that decrease of p16 arginine methylation level promoted the association of p16 with CDK4.	Arginine	74-82	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-73
23032699-6	2012	Furthermore, co-immunoprecipitation assays suggested that decrease of p16 arginine methylation level promoted the association of p16 with CDK4.	Arginine	74-82	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
23032699-7	2012	Additionally, we determined that the protein arginine methyltransferase 6 (PRMT6) was responsible for the p16 arginine methylation.	Arginine	45-53	protein arginine methyltransferase 6	Homo sapiens	75-80
23032699-7	2012	Additionally, we determined that the protein arginine methyltransferase 6 (PRMT6) was responsible for the p16 arginine methylation.	Arginine	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	106-109
23032699-10	2012	Together, data presented in this report establish that methylation at specific arginine residues of p16 protein by PRMT6 may be critical for the activity of p16.	Arginine	79-87	cyclin dependent kinase inhibitor 2A	Homo sapiens	100-103
23032699-10	2012	Together, data presented in this report establish that methylation at specific arginine residues of p16 protein by PRMT6 may be critical for the activity of p16.	Arginine	79-87	protein arginine methyltransferase 6	Homo sapiens	115-120
23032699-10	2012	Together, data presented in this report establish that methylation at specific arginine residues of p16 protein by PRMT6 may be critical for the activity of p16.	Arginine	79-87	cyclin dependent kinase inhibitor 2A	Homo sapiens	157-160
23053979-0	2012	p53 Codon 72 arginine/proline polymorphism and cancer in Sudan.	Arginine	13-21	tumor protein p53	Homo sapiens	0-3
23105135-4	2012	Additionally, when challenged with mycobacterial agonists, macrophages from TLR1 602S/S individuals resist induction of host arginase-1, an enzyme that depletes cellular arginine stores required for the production of antimicrobial reactive nitrogen intermediates.	Arginine	170-178	toll like receptor 1	Homo sapiens	76-80
22987726-2	2012	NO is synthesized from the amino acid L-arginine by nitric oxide synthases (NOS1, NOS2, and NOS3), which are encoded by separate genes and display different tissue distributions.	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	82-86
22987726-2	2012	NO is synthesized from the amino acid L-arginine by nitric oxide synthases (NOS1, NOS2, and NOS3), which are encoded by separate genes and display different tissue distributions.	Arginine	38-48	nitric oxide synthase 3	Homo sapiens	92-96
22183716-4	2012	Arginine deprivation induced a significant burst of p21cip1 in both cell lines that were reversible in MCF7 and irreversible in MCF10 cells.	Arginine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-59
23053979-1	2012	The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan.	Arginine	84-87	tumor protein p53	Homo sapiens	71-74
23053979-2	2012	p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR.	Arginine	12-15	tumor protein p53	Homo sapiens	0-3
23053979-5	2012	Breast carcinoma patients most prominently showed excess of homozygous arg genotype as compared to controls with an Odd ratio (OR) of 19.44, 95 %CI: 6.6-78.3, P &lt; 0.0001.	Arginine	71-74	odd-skipped related transcription factor 1	Homo sapiens	116-119
23053979-8	2012	We concluded that p53 arg/pro polymorphism has different pattern of frequency in different types of cancer among Sudanese patients, indicating perhaps different etiology and biology of these tumours.	Arginine	22-25	tumor protein p53	Homo sapiens	18-21
28153330-0	2012	Human Erythropoietin Gene Delivery Using an Arginine-grafted Bioreducible Polymer System.	Arginine	44-52	erythropoietin	Homo sapiens	6-20
23164735-1	2012	Nebivolol is a novel beta1-selective beta-blocker with vasodilator properties mediated through activation of the l-arginine-nitric oxide pathway.	Arginine	113-123	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	21-26
23047948-7	2012	This positive feedback function of Mek1 is independent of Mek1"s kinase activity, but dependent on Mek1"s forkhead-associated (FHA) domain and its arginine 51 residue.	Arginine	147-155	serine/threonine protein kinase MEK1	Saccharomyces cerevisiae S288C	35-39
23047948-8	2012	Arginine 51 directly mediates the interaction of Mek1-FHA and phosphorylated Hop1-T318.	Arginine	0-8	serine/threonine protein kinase MEK1	Saccharomyces cerevisiae S288C	49-53
23066109-0	2012	Recognition of asymmetrically dimethylated arginine by TDRD3.	Arginine	43-51	tudor domain containing 3	Homo sapiens	55-60
23079002-11	2012	In this study, we found that PRM1 variant rs35576928 (Arg&gt;Ser) played a protective role against severe oligozoospermia.	Arginine	54-57	protamine 1	Homo sapiens	29-33
23079002-14	2012	Our findings indicate that the PRM1 variant rs35576928 (Arg&gt;Ser) is associated with spermatogenesis defect in the Chinese Han population.	Arginine	56-59	protamine 1	Homo sapiens	31-35
23079002-0	2012	PRM1 variant rs35576928 (Arg&gt;Ser) is associated with defective spermatogenesis in the Chinese Han population.	Arginine	25-28	protamine 1	Homo sapiens	0-4
23127165-2	2012	Here we study the formation of amyloid fibrils from bovine insulin and the recombinant Lys(B31)-Arg(B32) human insulin analog.	Arginine	96-99	insulin	Homo sapiens	111-118
23461200-4	2012	The incubation of cells with L-arginine creates conditions for switching on the signal pathway with participation of eNOS --&gt; NO --&gt; sGC --&gt; cGMP --&gt; PKG --&gt; CD38 --&gt; RyR --&gt; Ca2+ and for switching of the PLC - IP3R-dependent pathway.	Arginine	29-39	ryanodine receptor 1, skeletal muscle	Mus musculus	185-188
23127165-5	2012	Although the differences in primary structure between bovine insulin and the Lys(B31)-Arg(B32) analog of human insulin lie outside of the polypeptide"s critical amyloidogenic regions, they affect the secondary structure of fibrils, possibly the formation of intermolecular salt bridges, and the susceptibility to dissection and denaturation with dimethyl sulfoxide (DMSO).	Arginine	86-89	insulin	Homo sapiens	111-118
23443113-4	2012	Nitric oxide (NO) is a gaseous molecule generated from L-arginine during the catalization of nitric oxide synthase (NOS), and it plays crucial roles in catalization and in the nervous, cardiovascular and immune systems.	Arginine	55-65	nitric oxide synthase 2	Homo sapiens	93-114
23103544-0	2012	L-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats.	Arginine	0-10	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
23060444-2	2012	RESULTS: A putative NEG2-CL3 electrostatic attraction, possibly weakened by Arg-764/Arg-766 of the R domain, prohibited CFTR activation.	Arginine	76-79	CF transmembrane conductance regulator	Homo sapiens	120-124
23060444-2	2012	RESULTS: A putative NEG2-CL3 electrostatic attraction, possibly weakened by Arg-764/Arg-766 of the R domain, prohibited CFTR activation.	Arginine	84-87	CF transmembrane conductance regulator	Homo sapiens	120-124
23103544-3	2012	In the present study we investigated, whether L-arginine supplementation would improve the myocardial antioxidant defense under hyperglycemia through activation of Nrf2 signaling.	Arginine	46-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-168
23103544-9	2012	qRT-PCR studies revealed that L-arginine treatment upregulated the transcription of Akt and downregulated NF-kappaB.	Arginine	30-40	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
23103544-11	2012	Under these findings, we suggest that targeting of eNOS and Nrf2 signaling by L-arginine supplementation could be used as a potential treatment method to alleviate the late diabetic complications.	Arginine	78-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	60-64
22968170-4	2012	Here, we show that arginine methylation modulates nuclear import of FUS via a novel TRN-binding epitope.	Arginine	19-27	FUS RNA binding protein	Homo sapiens	68-71
23011059-4	2012	A small fraction of arginine enters the NO synthase (NOS) pathway.	Arginine	20-28	nitric oxide synthase 2	Homo sapiens	40-51
23011059-9	2012	Reduced arginine availability stemming from reduced de novo production and elevated arginase activity have been reported in various conditions of acute and chronic stress, which are often characterized by increased NOS2 and reduced NOS3 activity.	Arginine	8-16	nitric oxide synthase 2	Homo sapiens	215-219
23011059-9	2012	Reduced arginine availability stemming from reduced de novo production and elevated arginase activity have been reported in various conditions of acute and chronic stress, which are often characterized by increased NOS2 and reduced NOS3 activity.	Arginine	8-16	nitric oxide synthase 3	Homo sapiens	232-236
23011059-11	2012	Therapeutic applications to influence (de novo) arginine and NO metabolism aim at increasing substrate availability or at influencing the metabolic fate of specific pathways related to NO bioavailability and prevention of NOS3 uncoupling.	Arginine	48-56	nitric oxide synthase 3	Homo sapiens	222-226
22968170-0	2012	Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	92-95
22968170-5	2012	Chemical or genetic inhibition of arginine methylation restores TRN-mediated nuclear import of ALS-associated FUS mutants.	Arginine	34-42	FUS RNA binding protein	Homo sapiens	110-113
22968170-8	2012	Together with recent findings that FUS co-aggregates with two related proteins of the FET family and TRN in FTLD-FUS but not in ALS-FUS, our study provides evidence that these two diseases may be initiated by distinct pathomechanisms and implicates alterations in arginine methylation in pathogenesis.	Arginine	264-272	FUS RNA binding protein	Homo sapiens	35-38
23085990-0	2012	The FUS about arginine methylation in ALS and FTLD.	Arginine	14-22	FUS RNA binding protein	Homo sapiens	4-7
23014354-0	2012	The L-arginine/asymmetric dimethylarginine ratio is improved by anti-tumor necrosis factor-alpha therapy in inflammatory arthropathies.	Arginine	4-14	tumor necrosis factor	Homo sapiens	69-96
22995517-2	2012	Dimethylarginine dimethylaminohydrolase (DDAH), which has 2 isoforms, metabolizes asymmetrically methylated arginines (asymmetric mono- or di-methylarginine), endogenously produced NO synthase inhibitors.	Arginine	108-117	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	0-39
22995517-2	2012	Dimethylarginine dimethylaminohydrolase (DDAH), which has 2 isoforms, metabolizes asymmetrically methylated arginines (asymmetric mono- or di-methylarginine), endogenously produced NO synthase inhibitors.	Arginine	108-117	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	41-45
22969085-6	2012	Based on reported mutagenesis data and comparison of the VanG and VanA structures, we show that residues Asp-243, Phe-252, and Arg-324 are molecular determinants for d-Ser selectivity.	Arginine	127-130	VanA	Enterococcus faecalis	66-70
23014354-4	2012	We examined the effect of TNF-alpha antagonists on ADMA and l-arginine/ADMA, and associations between ADMA, L-arginine/ADMA, aortic stiffness and carotid intima media thickness (CIMT) in patients with inflammatory arthropathies.	Arginine	60-70	tumor necrosis factor	Homo sapiens	26-35
23014354-9	2012	Baseline aPWV was associated with ADMA (P = 0.02) and L-arginine/ADMA (P = 0.02) in multiple regression analyses, and the L-arginine/ADMA ratio was continuously associated with aPWV after initiation of anti-TNF-alpha therapy (P = 0.03).	Arginine	122-132	tumor necrosis factor	Homo sapiens	207-216
23014354-11	2012	CONCLUSION: Anti-TNF-alpha therapy improved the L-arginine/ADMA ratio in patients with inflammatory arthropathies.	Arginine	48-58	tumor necrosis factor	Homo sapiens	17-26
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	BCL2 apoptosis regulator	Homo sapiens	68-73
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	BCL2 apoptosis regulator	Homo sapiens	140-144
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	mitogen-activated protein kinase 8	Homo sapiens	49-54
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	mitogen-activated protein kinase 8	Homo sapiens	56-59
22269898-8	2012	Animals supplemented with parenteral arginine had significantly decreased productions of concanavalin (Con) A- and lipopolysaccharide (LPS)-stimulated TNF-alpha in PBLs and splenocytes, spontaneous IL-6 and LPS-stimulated IFN-gamma in PBLs, and LPS-stimulated IL-6 in splenocytes.	Arginine	37-45	tumor necrosis factor	Rattus norvegicus	151-160
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	BCL2 apoptosis regulator	Homo sapiens	62-66
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Arginine	70-73	membrane metalloendopeptidase	Homo sapiens	9-19
22892830-1	2012	The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients.	Arginine	4-7	tumor protein p53	Homo sapiens	28-31
22892830-1	2012	The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients.	Arginine	4-7	tumor protein p53	Homo sapiens	95-98
22942126-4	2012	The Am-tra2 transcripts are alternatively (but non-sex-specifically) spliced, and they are translated into six protein isoforms that all share the basic RNA-binding domain/RS (arginine/serine) domain structure.	Arginine	176-184	transformer-2 sex-determining protein	Apis mellifera	7-11
23025756-5	2012	This suppression was partially reversed by catalase addition (P &lt; 0 01) and largely reversed by addition of exogenous interleukin-2 (P &lt; 0 001) but was not significantly reduced by nitric oxide synthase inhibition, myeloperoxidase inhibition or addition of excess arginine.	Arginine	270-278	interleukin 2	Homo sapiens	121-134
23044006-8	2012	In addition to these two IRCs, the B5K strain produced three different IRCs, Arg(A(0))-insulin (IRC 1), prepeptide-insulin (IRC 2), and Glu(A(22))-insulin (IRC 3).	Arginine	77-80	insulin	Homo sapiens	87-94
23044006-10	2012	Among these IRCs, Arg(A(0))-insulin, prepeptide-insulin, and desthreonine insulin originated from incomplete enzyme reaction.	Arginine	18-21	insulin	Homo sapiens	28-35
23044006-16	2012	Arg(B(31))-insulin originated from incomplete enzyme reaction.	Arginine	0-3	insulin	Homo sapiens	11-18
22269898-8	2012	Animals supplemented with parenteral arginine had significantly decreased productions of concanavalin (Con) A- and lipopolysaccharide (LPS)-stimulated TNF-alpha in PBLs and splenocytes, spontaneous IL-6 and LPS-stimulated IFN-gamma in PBLs, and LPS-stimulated IL-6 in splenocytes.	Arginine	37-45	interleukin 6	Rattus norvegicus	198-202
22269898-8	2012	Animals supplemented with parenteral arginine had significantly decreased productions of concanavalin (Con) A- and lipopolysaccharide (LPS)-stimulated TNF-alpha in PBLs and splenocytes, spontaneous IL-6 and LPS-stimulated IFN-gamma in PBLs, and LPS-stimulated IL-6 in splenocytes.	Arginine	37-45	interleukin 6	Rattus norvegicus	260-264
22269898-10	2012	High-dose arginine significantly increased spontaneous TNF-alpha, and Con A stimulated IL-4 and IL-6 in PBLs.	Arginine	10-18	tumor necrosis factor	Rattus norvegicus	55-64
22269898-10	2012	High-dose arginine significantly increased spontaneous TNF-alpha, and Con A stimulated IL-4 and IL-6 in PBLs.	Arginine	10-18	interleukin 6	Rattus norvegicus	96-100
23040521-6	2012	Subjects had significantly increased levels of argininosuccinate (P&lt;0.03) and AST levels (P&lt;0.01) after treatment with high-dose arginine.	Arginine	135-143	solute carrier family 17 member 5	Homo sapiens	81-84
23040521-7	2012	In the subset of subjects with elevated AST or ALT, treatment with high-dose of arginine was associated with further increases in plasma levels of both aminotransferases.	Arginine	80-88	solute carrier family 17 member 5	Homo sapiens	40-43
23040521-10	2012	CONCLUSIONS: Administering higher doses of arginine in subjects with ASA results in increases in AST and ALT levels, especially in the subset of patients with elevated baseline aminotransferases.	Arginine	43-51	solute carrier family 17 member 5	Homo sapiens	97-100
22889169-0	2012	A conserved N-terminal arginine-motif in GOLPH3-family proteins mediates binding to coatomer.	Arginine	23-31	golgi phosphoprotein 3	Homo sapiens	41-47
22889169-2	2012	We identify a cluster of arginine residues at the N-terminal end of GOLPH3 proteins that are necessary and sufficient to mediate coatomer binding.	Arginine	25-33	golgi phosphoprotein 3	Homo sapiens	68-74
22832094-7	2012	Stabilization of complexed insulin against enzymatic degradation by trypsin and alpha-chymotrypsin is observed especially for the high molecular weight PEGylated arginine-based derivative.	Arginine	162-170	insulin	Homo sapiens	27-34
23071334-2	2012	PRMT5 symmetrically di-methylates the two-terminal omega-guanidino nitrogens of arginine residues on substrate proteins.	Arginine	80-88	protein arginine methyltransferase 5	Homo sapiens	0-5
22932905-4	2012	Transcriptional regulation of SEPP1 is directed by the same transcription factors that control the expression of G6PC and PCK1, and these factors are activated by methylation of arginine residues.	Arginine	178-186	selenoprotein P	Homo sapiens	30-35
22217383-0	2012	Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.	Arginine	8-18	AKT serine/threonine kinase 1	Homo sapiens	98-101
22217383-0	2012	Dietary L-arginine supplementation improves the intestinal development through increasing mucosal Akt and mammalian target of rapamycin signals in intra-uterine growth retarded piglets.	Arginine	8-18	mechanistic target of rapamycin kinase	Homo sapiens	106-135
22217383-10	2012	Diet supplemented with Arg also increased (P &lt; 0 05) the levels of Arg, insulin, phosphorylated Akt and mTOR in SI mucosa of IUGR piglets, and decreased (P &lt; 0 05) the AI and caspase-3 activity.	Arginine	23-26	insulin	Homo sapiens	75-82
22217383-10	2012	Diet supplemented with Arg also increased (P &lt; 0 05) the levels of Arg, insulin, phosphorylated Akt and mTOR in SI mucosa of IUGR piglets, and decreased (P &lt; 0 05) the AI and caspase-3 activity.	Arginine	23-26	AKT serine/threonine kinase 1	Homo sapiens	99-102
22217383-10	2012	Diet supplemented with Arg also increased (P &lt; 0 05) the levels of Arg, insulin, phosphorylated Akt and mTOR in SI mucosa of IUGR piglets, and decreased (P &lt; 0 05) the AI and caspase-3 activity.	Arginine	23-26	mechanistic target of rapamycin kinase	Homo sapiens	107-111
22217383-10	2012	Diet supplemented with Arg also increased (P &lt; 0 05) the levels of Arg, insulin, phosphorylated Akt and mTOR in SI mucosa of IUGR piglets, and decreased (P &lt; 0 05) the AI and caspase-3 activity.	Arginine	23-26	caspase 3	Homo sapiens	181-190
22217383-11	2012	In conclusion, Arg has a beneficiary effect in improving the impaired SI development in IUGR piglets via regulating cell apoptosis and activating Akt and mTOR signals in SI mucosa.	Arginine	15-18	AKT serine/threonine kinase 1	Homo sapiens	146-149
22217383-11	2012	In conclusion, Arg has a beneficiary effect in improving the impaired SI development in IUGR piglets via regulating cell apoptosis and activating Akt and mTOR signals in SI mucosa.	Arginine	15-18	mechanistic target of rapamycin kinase	Homo sapiens	154-158
23115806-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
22832094-8	2012	Insulin release rates in simulated intestinal fluid are controlled by the length of PEG chains and the presence of arginine end-groups.	Arginine	115-123	insulin	Homo sapiens	0-7
22420465-8	2012	All four deiminated arginines and one acetylated lysine were first experimentally revealed in this study for bovine MBP.	Arginine	20-29	myelin basic protein	Bos taurus	116-119
22420465-10	2012	A few PTMs were also revealed in rattlesnake MBP: mono- and dimethylated Arg, protein N-terminal acetylation, and deiminated Arg.	Arginine	73-76	myelin basic protein	Bos taurus	45-48
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Arginine	149-152	transportin 3	Homo sapiens	124-131
22420465-10	2012	A few PTMs were also revealed in rattlesnake MBP: mono- and dimethylated Arg, protein N-terminal acetylation, and deiminated Arg.	Arginine	125-128	myelin basic protein	Bos taurus	45-48
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Arginine	180-183	transportin 3	Homo sapiens	124-131
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Arginine	106-109	proopiomelanocortin	Homo sapiens	114-123
22872638-7	2012	Through site-specific mutagenesis, we defined the following sets of amino acids in IN as important for the interaction with TRN-SR2: Phe-185/Lys-186/Arg-187/Lys-188 in the CCD and Arg-262/Arg-263/Lys-264 and Lys-266/Arg-269 in the CTD.	Arginine	180-183	transportin 3	Homo sapiens	124-131
22252936-6	2012	Matured osteoclasts expressed mRNA for the amino acid transporter B(0,+) (ATB(0,+) ) and the system alanine, serine, and cysteine amino acid transporter-2 (ASCT2), which are individually capable of similarly incorporating extracellular L- and D-Ser.	Arginine	236-238	solute carrier family 1 member 5	Rattus norvegicus	156-161
22696147-8	2012	Finally, both Arg- and Lys-gingipains purified from P. gingivalis were found to modulate fibronectin fragmentation.	Arginine	14-17	fibronectin 1	Homo sapiens	89-100
22532369-3	2012	Previously, it was demonstrated that protein arginine methyltransferase 1 (PRMT1)-dependent arginine modification of FoxO1 interferes with Akt-dependent phosphorylation, both in cancer cells and in the Caenorhabditis elegans model, suggesting that this additional modification of FoxO1 might be critical in its transcriptional activity.	Arginine	45-53	thymoma viral proto-oncogene 1	Mus musculus	139-142
22402736-6	2012	Endothelial nitric oxide synthase (eNOS) activation was measured by conversion of L-arginine to L-citrulline in endothelial cells incubated with HDL from 49 subjects.	Arginine	82-92	nitric oxide synthase 3	Homo sapiens	0-33
22643973-6	2012	We have identified three amino-terminal domains of Nef as necessary for secretion: (i) the four arginine residues (17,19,21, 22) comprising the basic region; (ii) the phosphofurin acidic cluster sequence (PACS) composed of four glutamic acid residues (61-64); (iii) a previously unknown motif spanning amino acid residues 65-69 (VGFPV) which we named the secretion modification region (SMR).	Arginine	96-104	S100 calcium binding protein B	Homo sapiens	51-54
22885934-5	2012	Analysis of tobacco (Nicotiana tabacum) Osmotic Stress-Activated Protein Kinase activity in tobacco Bright Yellow 2 cells indicates that reactive oxygen species (ROS) and nitric oxide, produced mainly via an l-arginine-dependent process, contribute to the kinase activation in response to cadmium.	Arginine	208-218	mitogen-activated protein kinase kinase kinase NPK1	Nicotiana tabacum	65-79
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	139-149	nitric oxide synthase 2, inducible	Mus musculus	32-63
22771373-5	2012	DPPB (1-10 muM) treatment for 24 h induced a significant and dose-dependent increase in eNOS activity as determined by the [(14)C]L-arginine/[(14)C]L-citrulline conversion assay.	Arginine	130-140	latexin	Homo sapiens	11-14
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	139-149	nitric oxide synthase 2, inducible	Mus musculus	65-69
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	151-156	nitric oxide synthase 2, inducible	Mus musculus	32-63
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	151-156	nitric oxide synthase 2, inducible	Mus musculus	65-69
22711313-1	2012	Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine and oxygen by the enzyme nitric oxide synthase (NOS).	Arginine	83-93	nitric oxide synthase 2	Homo sapiens	119-140
22708516-1	2012	PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl groups from S-adenosyl methionine to the arginine residues of histones or non-histone proteins and is involved in a variety of cellular processes.	Arginine	15-23	protein arginine methyltransferase 5	Homo sapiens	0-5
22759779-0	2012	Arg(972) insulin receptor substrate-1 is associated with elevated plasma endothelin-1 level in hypertensives.	Arginine	0-3	endothelin 1	Homo sapiens	73-85
21978975-0	2012	Responses to GHRH plus arginine test are more concordant with IGF-I circulating levels than responses to arginine and clonidine provocative tests.	Arginine	23-31	insulin like growth factor 1	Homo sapiens	62-67
22759779-1	2012	OBJECTIVES: To explore the association among Arg(972) insulin receptor substrate-1 (IRS-1), hypertension, insulin resistance, and plasma levels of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1).	Arginine	45-48	insulin	Homo sapiens	54-61
22759779-7	2012	CONCLUSIONS: Based on both in-vivo and in-vitro data, we have shown a potential causal association between Arg(972) IRS-1 and elevated plasma ET-1 level in hypertensives, which may account for the aggravated hypertension observed in hypertensives with heterozygous Arg(972) IRS-1.	Arginine	265-268	endothelin 1	Homo sapiens	142-146
22759779-1	2012	OBJECTIVES: To explore the association among Arg(972) insulin receptor substrate-1 (IRS-1), hypertension, insulin resistance, and plasma levels of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1).	Arginine	45-48	nitric oxide synthase 3	Homo sapiens	147-180
22759779-5	2012	RESULTS: There was no significant difference in allelic frequency between patients with and without primary hypertension or insulin resistance, in the hypertensives, heterozygous Arg(972) IRS-1 carriers had significantly higher plasma ET-1 levels and blood pressure (BP) than the homozygous carriers.	Arginine	179-182	endothelin 1	Homo sapiens	235-239
22759779-6	2012	Although shear stress decreased ET-1 expression in control HUVECs as well as cells transfected with wild type Arg(972) IRS-1, it increased the mRNA dose-dependently and secreted protein levels of ET-1 in cells transfected with Arg(972) IRS-1.	Arginine	110-113	endothelin 1	Homo sapiens	196-200
22759779-6	2012	Although shear stress decreased ET-1 expression in control HUVECs as well as cells transfected with wild type Arg(972) IRS-1, it increased the mRNA dose-dependently and secreted protein levels of ET-1 in cells transfected with Arg(972) IRS-1.	Arginine	227-230	endothelin 1	Homo sapiens	196-200
22759779-7	2012	CONCLUSIONS: Based on both in-vivo and in-vitro data, we have shown a potential causal association between Arg(972) IRS-1 and elevated plasma ET-1 level in hypertensives, which may account for the aggravated hypertension observed in hypertensives with heterozygous Arg(972) IRS-1.	Arginine	107-110	endothelin 1	Homo sapiens	142-146
22137265-0	2012	L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	26-30
22137265-4	2012	The present study tested the hypothesis that Arg stimulates the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis in porcine conceptus trophectoderm (pTr2) cells.	Arginine	45-48	mechanistic target of rapamycin kinase	Homo sapiens	64-93
22137265-4	2012	The present study tested the hypothesis that Arg stimulates the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis in porcine conceptus trophectoderm (pTr2) cells.	Arginine	45-48	mechanistic target of rapamycin kinase	Homo sapiens	95-99
22137265-8	2012	Addition of 100 and 350 muM Arg to culture medium dose-dependently increased (a) protein synthesis and decreased protein degradation and (b) the abundance of total and phosphorylated mTOR, p70S6K and 4EBP1 proteins.	Arginine	28-31	mechanistic target of rapamycin kinase	Homo sapiens	183-187
22401943-5	2012	Ammonia treatment increased the expression of the brain specific y(+)L isoform, y(+)LAT2, both at the mRNA and protein level, and silencing of the Slc7a6 gene coding for y(+)LAT2 protein specifically reduced the ammonia-induced [(3)H]Arg uptake.	Arginine	234-237	solute carrier family 7 member 6	Rattus norvegicus	147-153
22751928-5	2012	We also identified three arginine residues of beta-TrCP that participate in Nrf2 docking.	Arginine	25-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
22692183-7	2012	p53 allele frequency             for Arg/Arg was 43.6% (34/78), for Arg/Pro 37.2% (29/78) and for Pro/Pro 19.2%             (15/78).	Arginine	37-40	tumor protein p53	Homo sapiens	0-3
22692183-7	2012	p53 allele frequency             for Arg/Arg was 43.6% (34/78), for Arg/Pro 37.2% (29/78) and for Pro/Pro 19.2%             (15/78).	Arginine	41-44	tumor protein p53	Homo sapiens	0-3
22692183-7	2012	p53 allele frequency             for Arg/Arg was 43.6% (34/78), for Arg/Pro 37.2% (29/78) and for Pro/Pro 19.2%             (15/78).	Arginine	41-44	tumor protein p53	Homo sapiens	0-3
22692183-10	2012	Although the p53 arginine allele is itself             an important risk factor for cervical cancer, the combined risk with LOH of Rb,             which appears to be greater, might indicate a possible epistatic effect of the             two genes/polymorphisms.	Arginine	17-25	tumor protein p53	Homo sapiens	13-16
22686132-0	2012	Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.	Arginine	42-50	solute carrier family 30 member 8	Homo sapiens	86-90
22686132-0	2012	Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.	Arginine	42-50	insulin	Homo sapiens	107-116
22686132-0	2012	Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.	Arginine	42-50	solute carrier family 30 member 8	Homo sapiens	66-84
22686132-6	2012	RESULTS: The levels of all ZnT8Ab [ZnT8Arg (arginine), ZnT8Trp (tryptophan), ZnT8Gln (glutamine)] tended to decrease during disease progression.	Arginine	44-52	solute carrier family 30 member 8	Homo sapiens	27-31
22787143-6	2012	Noticeably, arginine transport by the hCAT-2/SLC7A14 chimera was pH-dependent, trans-stimulated, and inhibited by alpha-trimethyl-L-lysine, properties assigned to lysosomal transport system c in human skin fibroblasts.	Arginine	12-20	solute carrier family 7 member 14	Homo sapiens	45-52
22787143-0	2012	A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.	Arginine	123-131	solute carrier family 7 member 14	Homo sapiens	63-70
22686132-9	2012	CONCLUSIONS: The levels of the Arg variant of the ZnT8 autoantibodies are associated with higher levels of stimulated C-peptide after diagnosis of T1D and during follow-up.	Arginine	31-34	solute carrier family 30 member 8	Homo sapiens	50-54
22686132-9	2012	CONCLUSIONS: The levels of the Arg variant of the ZnT8 autoantibodies are associated with higher levels of stimulated C-peptide after diagnosis of T1D and during follow-up.	Arginine	31-34	insulin	Homo sapiens	118-127
22929836-7	2012	Nitric oxide (NO) synthase which comes in three isoforms, as inducible-, neuronal- and endothelial-NOS, or iNOS, nNOS or eNOS, respectively, catalyzes the conversion of L- arginine to L-citrulline, using NADPH to produce NO.	Arginine	169-180	nitric oxide synthase 2	Homo sapiens	107-111
22730318-2	2012	Argininosuccinate synthase (AS) is a ubiquitous enzyme in mammals and the key enzyme of the NO-citrulline cycle, because it provides the substrate L-arginine for subsequent NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS).	Arginine	147-157	nitric oxide synthase 2	Homo sapiens	226-237
22947940-7	2012	hAQP1 shows how the p(f) correlates with structural changes around the aromatic/arginine region of the pore.	Arginine	80-88	aquaporin 1 (Colton blood group)	Homo sapiens	0-5
22929836-7	2012	Nitric oxide (NO) synthase which comes in three isoforms, as inducible-, neuronal- and endothelial-NOS, or iNOS, nNOS or eNOS, respectively, catalyzes the conversion of L- arginine to L-citrulline, using NADPH to produce NO.	Arginine	169-180	nitric oxide synthase 3	Homo sapiens	121-125
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Arginine	114-117	twist family bHLH transcription factor 1	Homo sapiens	25-31
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Arginine	114-117	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
22841042-3	2012	The developed QD based probe gives excellent selectivity and reproducibility (1.7% relative standard deviation for 11 replicate detections of 10 muM arginine) and low detection limit (3 s, 0.23 muM), and favors biological applications due to the effective elimination of interference from scattering light and autofluorescence.	Arginine	149-157	latexin	Homo sapiens	145-148
22841042-3	2012	The developed QD based probe gives excellent selectivity and reproducibility (1.7% relative standard deviation for 11 replicate detections of 10 muM arginine) and low detection limit (3 s, 0.23 muM), and favors biological applications due to the effective elimination of interference from scattering light and autofluorescence.	Arginine	149-157	latexin	Homo sapiens	194-197
22891766-5	2012	In this novel mechanism, TWIST1-mediated IL8 transcription is induced through the TWIST1 carboxy-terminal WR (Trp-Arg) domain instead of the classic DNA binding bHLH domain.	Arginine	114-117	twist family bHLH transcription factor 1	Homo sapiens	82-88
22665483-5	2012	In this investigation, we demonstrate that arginine 3765 of the MLL1 Win motif is required to co-immunoprecipitate WRAD from mammalian cells, suggesting that the WDR5-Win motif interaction is important for the assembly of the MLL1 core complex in vivo.	Arginine	43-51	WD repeat domain 5	Homo sapiens	162-166
22853951-0	2012	Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation.	Arginine	8-16	estrogen receptor 1	Homo sapiens	89-112
22853951-2	2012	Here, we found that stimulation of ERalpha-positive cells with 17beta-estradiol (E2) promotes global citrullination of histone H3 arginine 26 (H3R26) on chromatin.	Arginine	130-138	estrogen receptor 1	Homo sapiens	35-42
24832226-6	2012	In support of the Brim model, arginine to glutamate substitutions at positions 213, 215, and 320 also compromised these APOBEC3G activities.	Arginine	30-38	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	120-128
22068917-10	2012	Arginine only significantly decreased TNF-alpha mRNA abundance in the ileum, while glutamine significantly decreased both TNF-alpha and IL-10 mRNA in the ileum.	Arginine	0-8	tumor necrosis factor	Rattus norvegicus	38-47
22068917-11	2012	A combination of arginine and glutamine significantly decreased TNF-alpha and IL-1beta mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum.	Arginine	17-25	tumor necrosis factor	Rattus norvegicus	64-73
22068917-11	2012	A combination of arginine and glutamine significantly decreased TNF-alpha and IL-1beta mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum.	Arginine	17-25	interleukin 1 beta	Rattus norvegicus	78-86
22944684-0	2012	Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin.	Arginine	153-157	ETS transcription factor ELK3	Homo sapiens	32-36
22904127-5	2012	We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT).	Arginine	64-72	catalase	Homo sapiens	110-113
21997536-1	2012	Upregulation of L-arginine transport by pro-inflammatory mediators is a widely reported phenomenon which accompanies the expression of the inducible nitric oxide synthase (iNOS) enzyme in various cells.	Arginine	16-26	nitric oxide synthase 2	Rattus norvegicus	139-170
21997536-1	2012	Upregulation of L-arginine transport by pro-inflammatory mediators is a widely reported phenomenon which accompanies the expression of the inducible nitric oxide synthase (iNOS) enzyme in various cells.	Arginine	16-26	nitric oxide synthase 2	Rattus norvegicus	172-176
21997536-6	2012	Our current data directly demonstrate that induced L: -arginine transport is critically dependent on the activation of NF-kappaB, and further confirmed its role in the induction of iNOS in rat aortic smooth muscle cells.	Arginine	51-63	nitric oxide synthase 2	Rattus norvegicus	181-185
22636782-2	2012	An inducible nitric oxide synthase (iNOS) in various mammalian cells produces higher levels of NO  from l-arginine upon infections to eliminate pathogens.	Arginine	104-114	nitric oxide synthase 2	Homo sapiens	3-34
22522052-3	2012	We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production.	Arginine	44-47	kininogen 1	Homo sapiens	79-89
22522052-3	2012	We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production.	Arginine	44-47	kininogen 1	Homo sapiens	91-93
22522052-3	2012	We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production.	Arginine	44-47	mitogen-activated protein kinase 3	Homo sapiens	309-315
22716077-1	2012	In a brief overview, in NO-sGC-cGMP signaling in a blood vessel, l-arginine is converted in the endothelium monolayer by the endothelial nitric oxide synthase (eNOS) to NO which diffuses into both the vessel lumen and the vessel wall, thereby activating soluble guanylate cyclase (sGC).	Arginine	65-75	nitric oxide synthase 3	Homo sapiens	125-158
22508683-4	2012	The CCS mutation, p.Arg163Trp, predicts substitution of a highly conserved arginine residue at position 163, with tryptophan in domain II of CCS, which interacts directly with superoxide dismutase 1 (SOD1).	Arginine	75-83	superoxide dismutase 1	Homo sapiens	176-198
22508683-4	2012	The CCS mutation, p.Arg163Trp, predicts substitution of a highly conserved arginine residue at position 163, with tryptophan in domain II of CCS, which interacts directly with superoxide dismutase 1 (SOD1).	Arginine	75-83	superoxide dismutase 1	Homo sapiens	200-204
23130157-10	2012	Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core.	Arginine	57-60	apolipoprotein E	Mus musculus	13-29
22636782-2	2012	An inducible nitric oxide synthase (iNOS) in various mammalian cells produces higher levels of NO  from l-arginine upon infections to eliminate pathogens.	Arginine	104-114	nitric oxide synthase 2	Homo sapiens	36-40
23130157-10	2012	Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core.	Arginine	57-60	apolipoprotein E	Mus musculus	31-35
23130157-10	2012	Furthermore, apolipoprotein E (ApoE)-deficient mice with Arg-II deficiency (ApoE(-/-)Arg-II(-/-)) display reduced lesion size with characteristics of stable plaques, such as decreased macrophage inflammation and necrotic core.	Arginine	57-60	apolipoprotein E	Mus musculus	76-80
22709481-6	2012	Moreover, L-Arg-pretreated mice developed more splenic myeloid and plasmacytoid dendritic cells with up-regulated expression of MHC II, CD86 and TLR9.	Arginine	10-15	histocompatibility-2, MHC	Mus musculus	128-134
22491354-5	2012	The Arg(447) substitution in the TPH2 enzyme resulted in a significant reduction of the brain serotonin (5-HT) in vivo synthesis rate.	Arginine	4-7	tryptophan hydroxylase 2	Mus musculus	33-37
22442049-4	2012	Arginines in the middle RG and C-terminal RGG region of SERBP1 are methylated based on the analyses of different deletion constructs.	Arginine	0-9	SERPINE1 mRNA binding protein 1	Homo sapiens	56-62
22707142-7	2012	Our study suggests that, among Asians, the p53 codon 72 Arg/Arg genotype is associated with a modestly decreased risk of gastric cancer, and that this difference in genotype distribution may be associated with cancer stage, location, differentiation and metastasis.	Arginine	56-59	tumor protein p53	Homo sapiens	43-46
22707142-7	2012	Our study suggests that, among Asians, the p53 codon 72 Arg/Arg genotype is associated with a modestly decreased risk of gastric cancer, and that this difference in genotype distribution may be associated with cancer stage, location, differentiation and metastasis.	Arginine	60-63	tumor protein p53	Homo sapiens	43-46
22547391-7	2012	A p27 mutant in which K100 was substituted by arginine (p27-K100R) cannot be acetylated by PCAF and has a half-life much higher than that of p27WT.	Arginine	46-54	zinc ribbon domain containing 2	Homo sapiens	2-5
22547391-7	2012	A p27 mutant in which K100 was substituted by arginine (p27-K100R) cannot be acetylated by PCAF and has a half-life much higher than that of p27WT.	Arginine	46-54	zinc ribbon domain containing 2	Homo sapiens	56-59
22052810-2	2012	A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior.	Arginine	57-65	tumor protein p53	Homo sapiens	36-40
22052810-2	2012	A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior.	Arginine	57-65	tumor protein p53	Homo sapiens	120-123
22709481-6	2012	Moreover, L-Arg-pretreated mice developed more splenic myeloid and plasmacytoid dendritic cells with up-regulated expression of MHC II, CD86 and TLR9.	Arginine	10-15	CD86 antigen	Mus musculus	136-140
25683401-5	2012	Peptide Thr-Asn-Gly-Ile-Ile-Arg (TNGIIR) exhibited higher activity against ACE to other two new peptides.	Arginine	28-31	angiotensin I converting enzyme	Homo sapiens	75-78
22249977-0	2012	Impact of codon 72 Arg &gt; Pro single nucleotide polymorphism in TP53 gene in the risk of kangri cancer: a case control study in Kashmir.	Arginine	19-22	tumor protein p53	Homo sapiens	66-70
22414890-2	2012	The aims of this study were to determine the frequency of the Arg/Pro SNP in p53 in Thoroughbred mares on one stud in Brazil and to correlate p53 genotypes with reproductive performance.	Arginine	62-65	tumor protein p53	Equus caballus	77-80
22696221-1	2012	Endothelial nitric-oxide synthase (eNOS) utilizes l-arginine as its principal substrate, converting it to l-citrulline and nitric oxide (NO).	Arginine	50-60	nitric oxide synthase 3	Bos taurus	0-33
22696221-2	2012	l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase, providing the substrate arginine for eNOS and NO production in endothelial cells.	Arginine	28-38	argininosuccinate synthase 1	Bos taurus	55-81
22696221-2	2012	l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase, providing the substrate arginine for eNOS and NO production in endothelial cells.	Arginine	30-38	argininosuccinate synthase 1	Bos taurus	55-81
22778397-5	2012	The Kapbeta2-binding epitopes of the FUS PY-NLS consist of an N-terminal PGKM hydrophobic motif, a central arginine-rich alpha-helix, and a C-terminal PY motif.	Arginine	107-115	FUS RNA binding protein	Homo sapiens	37-40
22490677-7	2012	This correspondence is demonstrated by binding of integrin alpha(IIb)beta(3) to the fourth module seen in EM, VWC4, which bears the VWF Arg-Gly-Asp motif.	Arginine	136-139	von Willebrand factor	Homo sapiens	132-135
22762146-5	2012	RESULTS: Exposure of BM cells to GM-CSF and IL-6 activated, within 24 h, L-Arg metabolizing enzymes which are responsible for the MDSCs immunosuppressive potential.	Arginine	73-78	interleukin 6	Mus musculus	44-48
22577142-2	2012	In eukaryotes, the major way to generate N-degrons is through arginylation by ATE1 arginyl-tRNA-protein transferases, which transfer Arg from aminoacyl-tRNA to N-terminal Asp and Glu (and Cys as well in mammals).	Arginine	133-136	arginyltransferase 1	Mus musculus	78-82
22637473-2	2012	Through mutational analysis of HD5, we have identified arginine residues that contribute to antiviral activity against AdV and HPV.	Arginine	55-63	defensin alpha 5	Homo sapiens	31-34
22637473-3	2012	Of two arginine residues paired on one face of HD5, Arg-28 is critical for both viruses, while Arg-9 is only important for AdV.	Arginine	7-15	defensin alpha 5	Homo sapiens	47-50
22637473-3	2012	Of two arginine residues paired on one face of HD5, Arg-28 is critical for both viruses, while Arg-9 is only important for AdV.	Arginine	52-55	defensin alpha 5	Homo sapiens	47-50
22637473-3	2012	Of two arginine residues paired on one face of HD5, Arg-28 is critical for both viruses, while Arg-9 is only important for AdV.	Arginine	95-98	defensin alpha 5	Homo sapiens	47-50
22637473-10	2012	Rather, these studies confirm that the major mechanism of HD5-mediated neutralization of AdV depends upon specific binding to the viral capsid through interactions mediated in part by critical arginine residues, hydrophobicity at residue 29, and multimerization of HD5, which increases initial binding of virus to the cell but prevents subsequent viral uncoating and genome delivery to the nucleus.	Arginine	193-201	defensin alpha 5	Homo sapiens	58-61
22637474-4	2012	Mutational analyses have established that an interaction of the carboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2, suggesting that hydrophobic interactions between the omega-end of substrates and cyclooxygenase channel residues play a significant role in COX-2-mediated oxygenation.	Arginine	87-90	cytochrome c oxidase I, mitochondrial	Mus musculus	136-141
22731716-3	2012	Using an in vitro SUMOylation assay, we identified K218 as a conjugation site on claudin-2; mutation of that lysine to arginine blocked SUMOylation.	Arginine	119-127	claudin 2	Homo sapiens	81-90
22828337-9	2012	The results indicate that bsNOS, like iNOS, has the capacity to generate a pterin radical during Arg oxidation.	Arginine	97-100	nitric oxide synthase 2	Homo sapiens	38-42
22518022-0	2012	Arginine attenuates methylglyoxal- and high glucose-induced endothelial dysfunction and oxidative stress by an endothelial nitric-oxide synthase-independent mechanism.	Arginine	0-8	nitric oxide synthase 3	Homo sapiens	111-144
22539596-3	2012	Cadherin 6 is expressed on the platelet surface and contains an arginine-glycine-aspartic acid motif, suggesting that it might have a supportive role in thrombus formation.	Arginine	64-72	cadherin 6	Mus musculus	0-10
22539596-6	2012	Platelet adhesion to immobilized cadherin 6 was inhibited by arginine-glycine-aspartic acid-serine tetrapeptides.	Arginine	61-69	cadherin 6	Mus musculus	33-43
22577163-6	2012	The enzyme modulation by C-peptide was abolished when C-terminal basic lysine residue (K434) of the enzyme was replaced by neutral alanine or acidic glutamate, but not with basic arginine.	Arginine	179-187	insulin	Homo sapiens	25-34
22522653-4	2012	Furthermore, these cells readily express inducible nitric oxide synthase (iNOS), an enzyme that promotes T-cell tolerance by catabolism of the limiting amino acid arginine.	Arginine	163-171	nitric oxide synthase 2	Homo sapiens	41-72
22522653-4	2012	Furthermore, these cells readily express inducible nitric oxide synthase (iNOS), an enzyme that promotes T-cell tolerance by catabolism of the limiting amino acid arginine.	Arginine	163-171	nitric oxide synthase 2	Homo sapiens	74-78
22518022-2	2012	We tested the hypothesis that L-arginine, and its inactive isomer D-arginine, can efficiently scavenge MG, administered exogenously or produced endogenously from high glucose, and attenuate its harmful effects including endothelial dysfunction and oxidative stress by an endothelial nitric-oxide synthase (eNOS)-independent mechanism.	Arginine	30-40	nitric oxide synthase 3	Homo sapiens	271-304
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	213-221	PHD and ring finger domains 1	Homo sapiens	131-136
22532692-9	2012	More importantly, mutations of the arginine and lysine to alanine or glutamic acid in the receptor-binding region ablated the heparin-binding activity of apoE, as determined by an in vitro heparin pulldown assay.	Arginine	35-43	apolipoprotein E	Homo sapiens	154-158
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	213-221	interferon regulatory factor 7	Homo sapiens	167-171
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	223-226	interferon regulatory factor 7	Homo sapiens	167-171
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	223-226	interferon regulatory factor 7	Homo sapiens	177-181
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	213-221	interferon regulatory factor 7	Homo sapiens	177-181
22433914-2	2012	Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.	Arginine	223-226	PHD and ring finger domains 1	Homo sapiens	131-136
22356895-9	2012	In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use.	Arginine	46-49	tumor protein p53	Homo sapiens	97-100
22472948-0	2012	Human erythropoietin gene delivery using an arginine-grafted bioreducible polymer system.	Arginine	44-52	erythropoietin	Homo sapiens	6-20
22472948-3	2012	Here, we show the application of an arginine-grafted bioreducible poly(disulfide amine) (ABP) polymer gene delivery system as a platform for in vivo transfer of human erythropoietin plasmid DNA (phEPO) to produce long-term, therapeutic erythropoiesis.	Arginine	36-44	erythropoietin	Homo sapiens	167-181
22356895-9	2012	In contrast, the predictive utility of the 72 Arg/Pro SNP in p53 requires mutational analysis of p53, limiting its routine clinical use.	Arginine	46-49	tumor protein p53	Homo sapiens	61-64
26105290-10	2012	Nitric oxide is produced by the five-electron oxidation of L-arginine which is catalyzed by the enzyme eNOS.	Arginine	59-69	nitric oxide synthase 3	Homo sapiens	103-107
22615372-2	2012	ApoE4 contains an arginine residue at position 112, whereas apoE3 has a cysteine at this position.	Arginine	18-26	apolipoprotein E	Homo sapiens	0-5
22642810-5	2012	Mutation of these highly conserved arginines, including a replication of the prevalent MMACHC missense mutation, Arg161Gln, disrupts GSH binding and dealkylation.	Arginine	35-44	metabolism of cobalamin associated C	Homo sapiens	87-93
22650761-2	2012	We found that Rps2 is substoichiometrically modified at arginine-10 by the Rmt1 methyltransferase.	Arginine	56-64	ribosomal 40S subunit protein S2	Saccharomyces cerevisiae S288C	14-18
22650761-3	2012	We demonstrated that Rps3 is stoichiometrically modified by omega-monomethylation at arginine-146 by mass spectrometric and site-directed mutagenic analyses.	Arginine	85-93	ribosomal 40S subunit protein S3	Saccharomyces cerevisiae S288C	21-25
22650761-5	2012	Analysis of the three-dimensional structure of Rps3 in S. cerevisiae shows that arginine-146 makes contacts with the small subunit rRNA.	Arginine	80-88	ribosomal 40S subunit protein S3	Saccharomyces cerevisiae S288C	47-51
22535958-6	2012	Removal of the N-terminal 27 amino acids of Ostbeta resulted in a transporter complex that reached the plasma membrane and exhibited transport activity at 30  C. Complete deletion of the C terminus of Ostbeta abolished [(3)H]taurocholate transport activity, but reinsertion of two native arginines immediately C-terminal to the TM domain rescued this defect.	Arginine	288-297	solute carrier family 51 subunit beta	Homo sapiens	44-51
22535958-6	2012	Removal of the N-terminal 27 amino acids of Ostbeta resulted in a transporter complex that reached the plasma membrane and exhibited transport activity at 30  C. Complete deletion of the C terminus of Ostbeta abolished [(3)H]taurocholate transport activity, but reinsertion of two native arginines immediately C-terminal to the TM domain rescued this defect.	Arginine	288-297	solute carrier family 51 subunit beta	Homo sapiens	201-208
22642810-0	2012	Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.	Arginine	31-39	metabolism of cobalamin associated C	Homo sapiens	13-19
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Arginine	71-79	gastric inhibitory polypeptide	Rattus norvegicus	122-125
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Arginine	81-84	gastric inhibitory polypeptide	Rattus norvegicus	122-125
22572614-7	2012	The administration of L-Arg promoted the synthesis of NO and significantly elevated the expressions of VEGF, eNOS and PTC density with the conspicuous loss of HIF-1alpha and TGF-beta1 expressions and ultimately ameliorated renal fibrosis, which was markedly aggravated by L-NAME administration.	Arginine	22-27	transforming growth factor, beta 1	Rattus norvegicus	174-183
22591353-2	2012	Because there is no tRNA-Dnmt2 cocrystal structure available, we have mapped the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants.	Arginine	162-170	tRNA aspartic acid methyltransferase 1	Homo sapiens	102-107
21902583-1	2012	The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain.	Arginine	114-122	CD4 molecule	Homo sapiens	48-60
22258307-11	2012	CONCLUSION: This meta-analysis suggests that p53 codon 72 Pro/Pro + Arg/Pro genotypes are associated with increased risk of endometriosis in Asian.	Arginine	68-71	tumor protein p53	Homo sapiens	45-48
21638020-5	2012	Compared with the control diets, dietary Arg or NCG supplementation enhanced the reproductive performance of sows, significantly increased (P&lt;0.05) plasma arginine and decreased plasma VEGF and eNOS (P&lt;0.05).	Arginine	41-44	vascular endothelial growth factor A	Homo sapiens	188-192
21638020-5	2012	Compared with the control diets, dietary Arg or NCG supplementation enhanced the reproductive performance of sows, significantly increased (P&lt;0.05) plasma arginine and decreased plasma VEGF and eNOS (P&lt;0.05).	Arginine	41-44	nitric oxide synthase 3	Homo sapiens	197-201
21638020-8	2012	The expression of eNOS in both Arg-supplemented and NCG-supplemented group were lower (P&lt;0.05) than in the control group.	Arginine	31-34	nitric oxide synthase 3	Homo sapiens	18-22
21638020-9	2012	The expression of VEGFA was higher (P&lt;0.05) in the NCG-supplemented group than in the Arg-supplemented and the control group.	Arginine	89-92	vascular endothelial growth factor A	Homo sapiens	18-23
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Arginine	52-55	vascular endothelial growth factor A	Homo sapiens	129-134
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Arginine	52-55	nitric oxide synthase 3	Homo sapiens	139-143
21638020-0	2012	Effects of dietary L-arginine or N-carbamylglutamate supplementation during late gestation of sows on the miR-15b/16, miR-221/222, VEGFA and eNOS expression in umbilical vein.	Arginine	19-29	nitric oxide synthase 3	Homo sapiens	141-145
22682770-0	2012	Effect of dietary arginine and N-carbamoylglutamate supplementation on reproduction and gene expression of eNOS, VEGFA and PlGF1 in placenta in late pregnancy of sows.	Arginine	18-26	nitric oxide synthase 3	Homo sapiens	107-111
22682770-6	2012	The results showed that compared with the control group, the average birth weight of all piglets born alive were 16.2% and 14.3% higher in the Arg and NCG groups (P&lt;0.05), respectively; plasma VEGFA was higher in the Arg group (P&lt;0.05).	Arginine	143-146	vascular endothelial growth factor A	Homo sapiens	196-201
22682770-6	2012	The results showed that compared with the control group, the average birth weight of all piglets born alive were 16.2% and 14.3% higher in the Arg and NCG groups (P&lt;0.05), respectively; plasma VEGFA was higher in the Arg group (P&lt;0.05).	Arginine	220-223	vascular endothelial growth factor A	Homo sapiens	196-201
22682770-7	2012	The expression of VEGFA in the allantochorion tissue of the NCG-supplemented group was higher (P&lt;0.01), and tended to be higher in the Arg-supplemented group (0.05&lt;P&lt;0.1).	Arginine	138-141	vascular endothelial growth factor A	Homo sapiens	18-23
26558026-10	2012	l-Arginine was the next best effect to blockade the renin-angiotensin system for renoprotection.	Arginine	0-10	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	52-57
21477265-9	2012	An increased risk was also associated with the TP53 Pro/Pro genotype (OR = 2.19, 95% CI = 1.54-3.06) compared with the Arg/Arg genotype.	Arginine	119-122	tumor protein p53	Homo sapiens	47-51
22182949-0	2012	Arginine availability modulates arginine metabolism and TNFalpha production in peritoneal macrophages from Zucker Diabetic Fatty rats.	Arginine	0-8	tumor necrosis factor	Rattus norvegicus	56-64
22182949-6	2012	In parallel, Arg downregulated TNFalpha production in both groups and IL-6 only in control.	Arginine	13-16	tumor necrosis factor	Rattus norvegicus	31-39
22300440-6	2012	Also, CYP19A1 arginine allele in homozygosity or heterozygosity (TC/CC) was associated with a significant increased risk for breast cancer when associated to GSTM1 null genotype (OR=6.158; 95% CI=2.676-14.171; p&lt;0.001) and GSTT1 null genotype (OR=4.870; 95% CI=2.216-10.700; p&lt;0.001).	Arginine	14-22	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	6-13
22300440-6	2012	Also, CYP19A1 arginine allele in homozygosity or heterozygosity (TC/CC) was associated with a significant increased risk for breast cancer when associated to GSTM1 null genotype (OR=6.158; 95% CI=2.676-14.171; p&lt;0.001) and GSTT1 null genotype (OR=4.870; 95% CI=2.216-10.700; p&lt;0.001).	Arginine	14-22	glutathione S-transferase mu 1	Homo sapiens	158-163
22913215-0	2012	Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity.	Arginine	18-28	insulin	Homo sapiens	48-55
22913215-4	2012	AIM: The aim of the study was to evaluate the influence of L-arginine supplementation on tumor necrosis factor alpha, insulin resistance and selected anthropometric and biochemical parameters in patients with visceral obesity.	Arginine	59-69	tumor necrosis factor	Homo sapiens	89-116
22913215-4	2012	AIM: The aim of the study was to evaluate the influence of L-arginine supplementation on tumor necrosis factor alpha, insulin resistance and selected anthropometric and biochemical parameters in patients with visceral obesity.	Arginine	59-69	insulin	Homo sapiens	118-125
22913215-12	2012	We found that 3-month L-arginine supplementation resulted in significant decrease of HOMA-IR and insulin concentration.	Arginine	22-32	insulin	Homo sapiens	97-104
21477265-9	2012	An increased risk was also associated with the TP53 Pro/Pro genotype (OR = 2.19, 95% CI = 1.54-3.06) compared with the Arg/Arg genotype.	Arginine	123-126	tumor protein p53	Homo sapiens	47-51
22913215-15	2012	3-months L-arginine supplementation in a dose of 9 g improves insulin sensitivity in patients with visceral obesity with no impact on tumor necrosis factor alpha concentration.	Arginine	9-19	insulin	Homo sapiens	62-69
22682929-1	2012	Nitric oxide (NO) is synthesized from l-arginine by endothelium nitric oxide synthase (NOS3) and plays important roles in many physiologic and pathologic processes.	Arginine	38-48	nitric oxide synthase 3	Homo sapiens	87-91
22323043-7	2012	FBXW7 does not obviously follow a "continuum" or "fail-safe" model and the most common mutant genotypes are mono-allelic missense changes that affect critical arginine residues involved in interactions with substrates.	Arginine	159-167	F-box and WD repeat domain containing 7	Homo sapiens	0-5
22734755-3	2012	Mice (five per group) were intravenously treated with an Arg-Gly-Asp peptide-nanoparticle/Raf-1 kinase inhibitor protein complex [RGD-NP/RAF(-)] or with a nanoparticle control.	Arginine	57-60	zinc fingers and homeoboxes 2	Mus musculus	137-140
22517776-4	2012	Mutated arginine makes hPTH" fill the receptor cavity better as well as forms hydrogen bonds with Val193.	Arginine	8-16	parathyroid hormone	Homo sapiens	23-28
22651890-4	2012	We hypothesized that any Nef-SH3 domain interactions would be lost upon mutation of the prolines or arginine of PXXPXR.	Arginine	100-108	S100 calcium binding protein B	Homo sapiens	25-28
22273601-3	2012	Signals comparable to those obtained with BSA were observed with poly(L-Trp, L-Lys), poly(L-Trp, L-Arg) or poly(L-Trp, L-Orn) at pH 7.0.	Arginine	97-102	albumin	Homo sapiens	42-45
22273601-9	2012	As a matter of fact, HSA and BSA contain an internal tryptophan in close proximity to lysine and arginine residues and therefore suitable for pi-cation interactions.	Arginine	97-105	albumin	Homo sapiens	29-32
22273601-12	2012	Based on preliminary results that have shown that LIOAS signal at 532 nm depended on the aggregation state of BSA and/or on the oxidation state of its Cys-34, we postulate that the LIOAS signal observed with proteins and tryptophan-containing polypeptides are related to Trp-Lys or Trp-Arg interactions and that the intensity of the signal depends on the strength of such interactions.	Arginine	286-289	albumin	Homo sapiens	110-113
22404651-0	2012	A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export.	Arginine	9-12	SEC24 homolog C, COPII coat complex component	Homo sapiens	75-81
22484228-1	2012	The present study was undertaken to develop a respirable sustained-release powder (RP) formulation of long-acting VIP derivative, [Arg(15, 20, 21), Leu(17)]-VIP-GRR (IK312532), using PLGA nanospheres (NS) with the aim of improving the duration of action.	Arginine	131-134	vasoactive intestinal peptide	Rattus norvegicus	114-117
22484228-1	2012	The present study was undertaken to develop a respirable sustained-release powder (RP) formulation of long-acting VIP derivative, [Arg(15, 20, 21), Leu(17)]-VIP-GRR (IK312532), using PLGA nanospheres (NS) with the aim of improving the duration of action.	Arginine	131-134	vasoactive intestinal peptide	Rattus norvegicus	157-160
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Arginine	66-74	S100 calcium binding protein B	Homo sapiens	103-106
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Arginine	66-74	S100 calcium binding protein B	Homo sapiens	120-123
21907263-4	2012	Arginine can be metabolized to nitric oxide and to polyamines or act directly to activate MTOR cell signaling to stimulate proliferation, migration, and mRNA translation in trophectoderm cells.	Arginine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	90-94
22461507-7	2012	Taken together, our findings offer mechanistic insight into arginine deprivation metabolism and ADI resistance, and they illustrate how combining inhibitors of the Ras/ERK and PI3K/AKT signaling pathways may improve ADI-PEG20 anticancer responses.	Arginine	60-68	mitogen-activated protein kinase 1	Homo sapiens	168-171
22461507-7	2012	Taken together, our findings offer mechanistic insight into arginine deprivation metabolism and ADI resistance, and they illustrate how combining inhibitors of the Ras/ERK and PI3K/AKT signaling pathways may improve ADI-PEG20 anticancer responses.	Arginine	60-68	AKT serine/threonine kinase 1	Homo sapiens	181-184
21996744-2	2012	To date, mutations in three active site arginine residues, IDH1 R132, IDH2 R172 and IDH2 R140, have been shown to result in the neomorphic production of 2HG.	Arginine	40-48	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	70-74
21996744-2	2012	To date, mutations in three active site arginine residues, IDH1 R132, IDH2 R172 and IDH2 R140, have been shown to result in the neomorphic production of 2HG.	Arginine	40-48	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	84-88
22649803-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
22649804-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
22542797-3	2012	Enzymatic activity of eNOS and intracellular BH4 levels were assessed by means of an arginine-citrulline conversion assay and HPLC analysis, respectively.	Arginine	85-93	nitric oxide synthase 3	Homo sapiens	22-26
22408254-7	2012	Mutation of lysine 19 in recombinant hGLYATL2 to glutamine (K19Q) and arginine (K19R) resulted in a 50-80% lower production of N-oleoyl glycine and N-arachidonoylglycine, indicating that lysine 19 is important for enzyme function.	Arginine	70-78	glycine-N-acyltransferase like 2	Homo sapiens	37-45
22361732-4	2012	L-Arg is utilized to produce nitric oxide (NO), by inducible NO synthase (iNOS), or L-ornithine (L-Orn) by arginase (Arg) enzymes.	Arginine	0-5	nitric oxide synthase 2, inducible	Mus musculus	51-72
22556244-2	2012	Here, we identify an arginine-to-cysteine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determinant of blond hair in Solomon Islanders.	Arginine	21-29	tyrosinase related protein 1	Homo sapiens	82-110
22556244-2	2012	Here, we identify an arginine-to-cysteine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determinant of blond hair in Solomon Islanders.	Arginine	21-29	tyrosinase related protein 1	Homo sapiens	112-117
22541562-8	2012	We show that mutation to arginine at this residue causes NSUN2 to fail to localize within the nucleolus.	Arginine	25-33	NOP2/Sun RNA methyltransferase 2	Homo sapiens	57-62
22361732-4	2012	L-Arg is utilized to produce nitric oxide (NO), by inducible NO synthase (iNOS), or L-ornithine (L-Orn) by arginase (Arg) enzymes.	Arginine	0-5	nitric oxide synthase 2, inducible	Mus musculus	74-78
22774401-1	2012	BACKGROUND: The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C-&gt;T) on insulin resistance in obese patients.	Arginine	85-93	insulin	Homo sapiens	216-223
22365930-9	2012	Mutation of the species conserved Arg-91 residue, that anchors the cleft, results in the greatest changes to physicochemical properties of the protein leading to a change in the CL binding ratio required to effect structural changes and to the ligand-exchange properties of the ferrous cytochrome c/CL complex.	Arginine	34-37	cytochrome c, somatic	Homo sapiens	286-298
22551548-6	2012	RESULTS: The analysis revealed a germline nonsense mutation in exon 8 at codon 306 of the codified region of the TP53 gene, causing a change of CGA to TGA (Arg Stop) in the proband, her mother, her cousin and her maternal uncle.	Arginine	156-159	tumor protein p53	Homo sapiens	113-117
22551548-6	2012	RESULTS: The analysis revealed a germline nonsense mutation in exon 8 at codon 306 of the codified region of the TP53 gene, causing a change of CGA to TGA (Arg Stop) in the proband, her mother, her cousin and her maternal uncle.	Arginine	156-159	chromogranin A	Homo sapiens	144-147
22377531-1	2012	To test the hypothesis that sidedness of interfacial arginine (Arg) in apoA-I mimetic peptides, similar to that observed in apoA-I (Bashtovyy, D. et al.	Arginine	53-61	apolipoprotein A1	Homo sapiens	71-77
21757511-2	2012	Sequence analysis revealed a substitution (C T) at position 2211 and a deletion of G at position 2213 in exon 3 of the AR gene, resulting in the conversion of arginine(CGG) to a stop codon (TGA) of the AR.	Arginine	159-167	androgen receptor	Homo sapiens	119-121
22377531-1	2012	To test the hypothesis that sidedness of interfacial arginine (Arg) in apoA-I mimetic peptides, similar to that observed in apoA-I (Bashtovyy, D. et al.	Arginine	63-66	apolipoprotein A1	Homo sapiens	71-77
22377531-12	2012	These studies support our hypothesis that the sidedness of interfacial Arg residues in the polar face of apoA-I mimetics results in differential biological properties.	Arginine	71-74	apolipoprotein A1	Homo sapiens	105-111
22433460-1	2012	Arginase induction can play a defensive role through the reduction of arginine availability for phytophageous insects.	Arginine	70-78	arginase	Arabidopsis thaliana	0-8
22311776-5	2012	We show that changes of lysine residues of the NLS (Nuclear Localization Signal) sequence of CRY2 to arginine residues partially impair the nuclear importation of the CRY2K541R and CRY2K554/5R mutant proteins, resulting in reduced phosphorylation, physiological activities, and degradation in response to blue light.	Arginine	101-109	cryptochrome 2	Arabidopsis thaliana	93-97
22764574-0	2012	Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B.	Arginine	0-8	albumin	Homo sapiens	22-35
22477015-7	2012	Direct sequencing of MYH9 revealed that he was heterozygous for a mutation in exon 1, which was a 97T&gt;A substitution mutation affecting codon 33, substituting tryptophan with arginine (Trp33Arg).	Arginine	178-186	myosin heavy chain 9	Homo sapiens	21-25
22032286-0	2012	Full-length recombinant choline transporter-like protein 2 containing arginine 154 reconstitutes the epitope recognized by HNA-3a antibodies.	Arginine	70-78	solute carrier family 44 member 2	Homo sapiens	24-58
22480683-5	2012	Enthalpy change as a function of input concentration of arginine to a fixed concentration of the enzyme (5 muM) shows a dip at 100 mM concentration of arginine.	Arginine	56-64	latexin	Homo sapiens	107-110
22860431-4	2012	L-Arg (500 mg/kg ip ,L-Arg group) or saline (control and LPS group) was administrated at 3 h or 6 h after LPS injection respectively for 3 h. The expression of surfactant protein A (SP-A) mRNA in the lung tissue was detected by ISH.	Arginine	0-5	surfactant protein A1	Rattus norvegicus	160-180
22860431-10	2012	Compared with LPS group at the same time points, treatment with L-Arg at 3 h after LPS, the expression of SP-A mRNA in lung tissue was increased markedly, whereas TP concentration was decreased significantly.	Arginine	64-69	surfactant protein A1	Rattus norvegicus	106-110
22860431-12	2012	LDH activity, TNF-alpha and IL-6 contents were decreased in L-Arg group compared with those of LPS group.	Arginine	60-65	tumor necrosis factor	Rattus norvegicus	14-23
22860431-12	2012	LDH activity, TNF-alpha and IL-6 contents were decreased in L-Arg group compared with those of LPS group.	Arginine	60-65	interleukin 6	Rattus norvegicus	28-32
22480683-5	2012	Enthalpy change as a function of input concentration of arginine to a fixed concentration of the enzyme (5 muM) shows a dip at 100 mM concentration of arginine.	Arginine	151-159	latexin	Homo sapiens	107-110
22399291-3	2012	In this study, we examined the role of a highly conserved salt bridge residing at the extracellular loop of rat ASIC3 (Asp(107)-Arg(153)) and human ASIC1a (Asp(107)-Arg(160)) channels.	Arginine	128-131	acid sensing ion channel subunit 3	Rattus norvegicus	112-117
22367195-4	2012	Mutagenesis analysis showed that four critical residues (Arg-82, Cys-83, Asn-86, and Ser-87) located in the IRF family conserved DNA binding domain-helix alpha3 were involved in DNA binding and POLH transactivation by IRF1.	Arginine	57-60	interferon regulatory factor 1	Homo sapiens	218-222
22442146-3	2012	IDH1 and IDH2 with cancer-associated mutations at the active site arginines were unable to carry out the reductive carboxylation of alphaKG.	Arginine	66-75	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
22334670-9	2012	We found that this amino acid (Arg) is conserved in the AtMYC1 homologs GL3/EGL3 and that it is essential for their interaction with MYB proteins and for their proper functions.	Arginine	31-34	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	56-62
22474388-3	2012	Here, we report on the identification of a fourth serine protease (NSP4) with 39% identity to NE and PR3, but arginine specificity, yet sharing features like propeptide processing by dipeptidyl peptidase I, storage, and release as an active enzyme with the three active proteases.	Arginine	110-118	coagulation factor II, thrombin	Homo sapiens	50-65
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	92-95	coagulation factor II, thrombin	Homo sapiens	0-8
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor II, thrombin	Homo sapiens	0-8
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor II, thrombin	Homo sapiens	0-8
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor II, thrombin	Homo sapiens	0-8
22455313-3	2012	Examination of the P3-P3" residues flanking each P1 site revealed that those sequences at Arg(740) and Arg(1689) are more optimal for thrombin cleavage than at Arg(372), suggesting these sequences may impact reaction rates.	Arginine	90-93	coagulation factor II, thrombin	Homo sapiens	134-142
22455313-3	2012	Examination of the P3-P3" residues flanking each P1 site revealed that those sequences at Arg(740) and Arg(1689) are more optimal for thrombin cleavage than at Arg(372), suggesting these sequences may impact reaction rates.	Arginine	103-106	coagulation factor II, thrombin	Homo sapiens	134-142
22455313-3	2012	Examination of the P3-P3" residues flanking each P1 site revealed that those sequences at Arg(740) and Arg(1689) are more optimal for thrombin cleavage than at Arg(372), suggesting these sequences may impact reaction rates.	Arginine	103-106	coagulation factor II, thrombin	Homo sapiens	134-142
22455313-6	2012	Rates of thrombin cleavage at Arg(372) were increased ~10- and ~3-fold compared with that of wild-type FVIII when it was replaced with P3-P3" residues flanking Arg(740) and Arg(1689), respectively, and these values paralleled increased rates of A2 subunit generation and procofactor activation.	Arginine	30-33	coagulation factor II, thrombin	Homo sapiens	9-17
22455313-6	2012	Rates of thrombin cleavage at Arg(372) were increased ~10- and ~3-fold compared with that of wild-type FVIII when it was replaced with P3-P3" residues flanking Arg(740) and Arg(1689), respectively, and these values paralleled increased rates of A2 subunit generation and procofactor activation.	Arginine	160-163	coagulation factor II, thrombin	Homo sapiens	9-17
22455313-6	2012	Rates of thrombin cleavage at Arg(372) were increased ~10- and ~3-fold compared with that of wild-type FVIII when it was replaced with P3-P3" residues flanking Arg(740) and Arg(1689), respectively, and these values paralleled increased rates of A2 subunit generation and procofactor activation.	Arginine	160-163	coagulation factor II, thrombin	Homo sapiens	9-17
22326500-1	2012	AIMS: Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS).	Arginine	56-61	nitric oxide synthase 2	Homo sapiens	188-201
22326500-1	2012	AIMS: Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS).	Arginine	56-61	nitric oxide synthase 2	Homo sapiens	203-207
22326500-1	2012	AIMS: Nitric oxide (NO) is synthesized from L-arginine (L-Arg) by three different isoforms of NO synthase (NOS), i.e. the constitutive neuronal and endothelial NOS (nNOS and eNOS) and the inducible NOS (iNOS).	Arginine	56-61	nitric oxide synthase 3	Homo sapiens	174-178
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Arginine	104-107	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
22430140-1	2012	Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3).	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	91-114
22430140-1	2012	Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3).	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	116-120
21892207-7	2012	Additionally, we show that c-Abl and Arg are not merely redundant, as active Arg drives invasion in a STAT3-independent manner, and upregulates MMP-3 and MT1-MMP, in addition to MMP-1.	Arginine	77-80	signal transducer and activator of transcription 3	Homo sapiens	102-107
22354633-7	2012	Using site-directed mutagenesis, we pinpoint several arginine residues and Y27 as important for HD-5 antibacterial activity.	Arginine	53-61	defensin alpha 5	Homo sapiens	96-100
22181833-3	2012	We have used four representative CR domains from the principal ligand-binding cluster of LRP to determine the energetics of interaction with well-defined small ligands that include methyl esters of lysine, arginine, histidine and aspartate, as well as N-terminally blocked lysine methyl ester.	Arginine	206-214	LDL receptor related protein 1	Homo sapiens	89-92
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Arginine	137-140	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
22327112-6	2012	Amino acids of HGPRT that are frequently involved in the binding of these compounds are Lys 66, Asp 74, Arg 77, Asp 81, Val 88, Tyr 182, Arg 192 and Arg 194.	Arginine	137-140	hypoxanthine-guanine phosphoribosyltransferase	Leishmania donovani	15-20
22189507-3	2012	Using limited proteolysis and mass spectrometry, two peptide regions, which correspond to Ser(100)-Arg(114) and His(89)-Arg(114) in BID, revealed the specific PS-binding site.	Arginine	99-102	BH3 interacting domain death agonist	Homo sapiens	132-135
21848502-5	2012	Results showed that 50 mug/mL of NAC, SDC, GSH, CS, Arg, Azone, SPC, SNP, and 10 mug/mL of SNP had a significant enhancing effect on promoting the transport of insulin across the TR146 cell model.	Arginine	52-55	insulin	Homo sapiens	160-167
22269951-4	2012	Here, we elucidate the molecular mechanism of HOXA9 activation by tumor necrosis factor alpha (TNF-alpha) and show an unexpected requirement for arginine methylation by protein arginine methyltransferase 5 (PRMT5).	Arginine	145-153	protein arginine methyltransferase 5	Homo sapiens	169-205
22269951-4	2012	Here, we elucidate the molecular mechanism of HOXA9 activation by tumor necrosis factor alpha (TNF-alpha) and show an unexpected requirement for arginine methylation by protein arginine methyltransferase 5 (PRMT5).	Arginine	145-153	protein arginine methyltransferase 5	Homo sapiens	207-212
23843806-0	2012	Effect of Arginine Infusion on Ghrelin Secretion in Growth Hormone Sufficient and GH Deficient Children.	Arginine	10-18	growth hormone 1	Homo sapiens	52-66
22278846-2	2012	The tip was modified with an antibody sensitive to the exposure of the arginine-glycine-aspartic acid (RGD) groups in FN.	Arginine	71-79	fibronectin 1	Homo sapiens	118-120
22316165-3	2012	Nitric oxide synthase (NOS) enzymes manufacture NO from L-arginine.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	0-21
22189507-3	2012	Using limited proteolysis and mass spectrometry, two peptide regions, which correspond to Ser(100)-Arg(114) and His(89)-Arg(114) in BID, revealed the specific PS-binding site.	Arginine	120-123	BH3 interacting domain death agonist	Homo sapiens	132-135
22291198-8	2012	The GDU1 protein encoded by the previously characterized intragenic suppressor mutant log1-1, with an arginine in place of a conserved glycine, failed to interact in the multiple assays, suggesting that the Gdu1D phenotype requires the interaction of GDU1 with LOG2.	Arginine	102-110	glutamine dumper 1	Arabidopsis thaliana	4-8
22187158-5	2012	The arginine- and cysteine-rich domains of Tat were required for IkappaB-alpha and p65 association, respectively, and for sustaining the NF-kappaB activity.	Arginine	4-12	NFKB inhibitor alpha	Homo sapiens	65-78
22457887-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	fibronectin 1	Homo sapiens	94-105
22079445-4	2012	MATERIALS AND METHODS: Compounds X-D-Arg-D-Phe-OMe, where X=residue of lauric or myristic acid or 9-fluorenylmethoxycarbonyl, have been synthesized by conventional peptide synthesis in solution and their comparative inhibitory analysis in relation to thrombin, factor X, plasmin and trypsin has been conducted.	Arginine	37-40	coagulation factor II, thrombin	Homo sapiens	251-259
22318724-8	2012	We demonstrate that the exon 8-encoded C-terminal arginine is essential for the interaction of VEGF-A with Nrp1 and mediates high affinity Nrp binding.	Arginine	50-58	vascular endothelial growth factor A	Homo sapiens	95-101
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Arginine	102-111	forkhead box O3	Homo sapiens	91-96
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Arginine	102-111	forkhead box O3	Homo sapiens	134-139
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Arginine	102-111	forkhead box O3	Homo sapiens	134-139
22390933-7	2012	In addition, we demonstrated the increases of PGI(2) release, COX-2 expression and p38MAPK phosphorylation, when nitric oxide level was raised through the incubation of L-arginine (10 or 20nmol/L) in endothelial cells.	Arginine	169-179	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
22457888-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	fibronectin 1	Homo sapiens	94-105
22457890-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	fibronectin 1	Homo sapiens	94-105
21681430-2	2012	Little is known about the concomitant presence of the ACE gene D allele and paraoxonase (PON1) codon 192 arginine (Arg) on the severity of CAD.	Arginine	105-113	paraoxonase 1	Homo sapiens	89-93
22199349-5	2012	PRMT5 is an arginine methyltransferase that symmetrically dimethylates arginine residues on target proteins to alter target protein function.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	0-5
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Arginine	141-144	tumor protein p53	Homo sapiens	6-10
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Arginine	145-148	tumor protein p53	Homo sapiens	6-10
22357201-2	2012	Among TP53 gene polymorphisms, the most studied is the G to C transversion in exon 4 at codon 72, which results in three distinct genotypes, Arg/Arg, Pro/Pro and Arg/Pro, each one encoding different p53 isoforms.	Arginine	145-148	tumor protein p53	Homo sapiens	6-10
22357201-7	2012	In our population, p53 genotypes were in Hardy-Weinberg (HW) equilibrium (X2 HM less than 3.84), showing a predominance of arginine allele (total Arg allele frequency of 68%).	Arginine	123-131	tumor protein p53	Homo sapiens	19-22
22357201-7	2012	In our population, p53 genotypes were in Hardy-Weinberg (HW) equilibrium (X2 HM less than 3.84), showing a predominance of arginine allele (total Arg allele frequency of 68%).	Arginine	146-149	tumor protein p53	Homo sapiens	19-22
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Arginine	12-22	mechanistic target of rapamycin kinase	Homo sapiens	82-111
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Arginine	12-22	mechanistic target of rapamycin kinase	Homo sapiens	113-117
22654866-0	2012	The Arginine Residue within the C-Terminal Active Core of Bombyx mori Pheromone Biosynthesis-Activating Neuropeptide is Essential for Receptor Binding and Activation.	Arginine	4-12	PBAN-type neuropeptides	Bombyx mori	70-116
22010633-5	2012	RESULTS:   Genetic analysis revealed compound heterozygosity for two novel putative loss of function mutations in POU1F1: a transition at position +3 of intron 1 [IVS1+3nt(A&gt;G)] and a point mutation in exon 6 resulting in a substitution of arginine by tryptophan (R265W).	Arginine	243-251	POU class 1 homeobox 1	Homo sapiens	114-120
22271514-7	2012	Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA-binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90beta in vitro, indicating that STAT3 requires a functional DNA-binding domain for full direct interaction with Hsp90.	Arginine	35-43	signal transducer and activator of transcription 3	Homo sapiens	26-31
22271514-7	2012	Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA-binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90beta in vitro, indicating that STAT3 requires a functional DNA-binding domain for full direct interaction with Hsp90.	Arginine	35-43	signal transducer and activator of transcription 3	Homo sapiens	185-190
22271514-7	2012	Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA-binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90beta in vitro, indicating that STAT3 requires a functional DNA-binding domain for full direct interaction with Hsp90.	Arginine	35-43	signal transducer and activator of transcription 3	Homo sapiens	185-190
21681430-2	2012	Little is known about the concomitant presence of the ACE gene D allele and paraoxonase (PON1) codon 192 arginine (Arg) on the severity of CAD.	Arginine	115-118	paraoxonase 1	Homo sapiens	89-93
21681430-3	2012	Regarding the high rate of CAD among Iranians the aim of present study was to examine the hypothesis of synergistic effects between ACE-D and PON1-Arg alleles on predisposition and the severity of CAD in our population.	Arginine	147-150	paraoxonase 1	Homo sapiens	142-146
21681430-7	2012	We found that PON1 Arg 192 and ACE D allele act synergistically to increase the risk of CAD (OR 1.3, P = 0.044).	Arginine	19-22	paraoxonase 1	Homo sapiens	14-18
21681430-8	2012	Our results showed a significant correlation between the possession of both PON1 192 Arg and the ACE D allele and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR 2.7, P = 0.046; chi(2) = 4, P = 0.046 and OR 2.4, P = 0.051; chi(2) = 3.8, P = 0.051, respectively.	Arginine	85-88	paraoxonase 1	Homo sapiens	76-80
21681430-9	2012	We found that PON1 Arg 192 and ACE D alleles act synergistically to increase the risk of CAD in CAD patients and CAD subjects without diabetes from west of Iran, who have high frequency of three-vessel disease.	Arginine	19-22	paraoxonase 1	Homo sapiens	14-18
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	31-34	paraoxonase 1	Homo sapiens	22-26
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	31-34	paraoxonase 1	Homo sapiens	174-178
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	31-34	angiotensin I converting enzyme	Homo sapiens	195-198
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	183-186	paraoxonase 1	Homo sapiens	22-26
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	183-186	angiotensin I converting enzyme	Homo sapiens	43-46
21681430-10	2012	Our data suggest that PON1 192 Arg and the ACE D allele in combination with each other can be important independent risk factor for severity of CAD in patients carrying both PON1 192 Arg and the ACE D allele in a west population of Iran.	Arginine	183-186	paraoxonase 1	Homo sapiens	174-178
22226999-3	2012	Adenosine deaminase acting on RNA 2 (ADAR2) specifically mediates RNA editing at the glutamine/arginine (Q/R) site of GluA2 and motor neurons expressing Q/R site-unedited GluA2 undergo slow death in conditional ADAR2 knockout mice.	Arginine	95-103	adenosine deaminase, RNA-specific, B1	Mus musculus	0-35
22264771-9	2012	Among the metabolites that contributed most to the CSF signature were arginine, lysine, ornithine, serine, threonine and pyroglutamic acid, all found to be reduced in patients carrying a D90A SOD1 mutation.	Arginine	70-78	superoxide dismutase 1	Homo sapiens	192-196
22226999-3	2012	Adenosine deaminase acting on RNA 2 (ADAR2) specifically mediates RNA editing at the glutamine/arginine (Q/R) site of GluA2 and motor neurons expressing Q/R site-unedited GluA2 undergo slow death in conditional ADAR2 knockout mice.	Arginine	95-103	adenosine deaminase, RNA-specific, B1	Mus musculus	37-42
22188168-1	2012	Arabidopsis possesses two arginase-encoding genes, ARGAH1 and ARGAH2, catalysing the catabolism of arginine into ornithine and urea.	Arginine	99-107	arginase	Arabidopsis thaliana	51-57
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	41-44	WD repeat domain 82 pseudogene 1	Homo sapiens	161-164
22490158-4	2012	The levels of acute insulin response (AIR) and acute C-peptide response (ACPR) were measured by a stimulation of arginine.	Arginine	113-121	insulin	Homo sapiens	53-62
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	53-56	WD repeat domain 82 pseudogene 1	Homo sapiens	161-164
22184126-11	2012	In contrast, replacing Arg(82), but not Arg(93), substantially reduces the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays a general role in substrate recognition, whereas Arg(93) specifically functions in NCAM recognition.	Arginine	23-26	cell adhesion molecule 1	Homo sapiens	133-141
22207756-1	2012	In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX (FIX) by cleaving the zymogen at Arg(145)-Ala(146) and Arg(180)-Val(181) bonds releasing an 11-kDa activation peptide.	Arginine	117-120	coagulation factor IX	Homo sapiens	74-83
22207756-1	2012	In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX (FIX) by cleaving the zymogen at Arg(145)-Ala(146) and Arg(180)-Val(181) bonds releasing an 11-kDa activation peptide.	Arginine	139-142	coagulation factor IX	Homo sapiens	74-83
22242891-0	2012	Improved synthesis of lysine- and arginine-derived Amadori and Heyns products and in vitro measurement of their angiotensin I-converting enzyme inhibitory activity.	Arginine	34-42	angiotensin I converting enzyme	Homo sapiens	112-143
21706189-9	2012	Hormonal alterations were only slight and no signs of anterior hypopituitarism were found except for an insufficient growth hormone rise in two overweight patients in the GHRH-ARG-test.	Arginine	176-179	growth hormone releasing hormone	Homo sapiens	171-175
22266372-1	2012	Protein arginine methyltransferase 5 (PRMT5) is an enzyme that transfers one or two methyl groups to the arginine residues of histones or non-histone proteins, and that plays critical roles in cellular processes as diverse as receptor signaling and gene expression.	Arginine	8-16	protein arginine methyltransferase 5	Homo sapiens	38-43
22062693-0	2012	Erythropoietin gene delivery using an arginine-grafted bioreducible polymer system.	Arginine	38-46	erythropoietin	Homo sapiens	0-14
22052013-2	2012	Along with nitric oxide synthase (NOS)-2, ASS endows cells with the L-citrulline/nitric oxide (NO ) salvage pathway to continually supply L-arginine from L-citrulline for sustained NO  generation.	Arginine	138-148	nitric oxide synthase 2, inducible	Mus musculus	11-40
22319801-15	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	149-159
21927815-1	2012	Human endothelial nitric oxide synthase (eNOS) is one isoform of the nitric oxide synthases that are responsible for nitric oxide synthesis from L-arginine.	Arginine	145-155	nitric oxide synthase 3	Homo sapiens	6-39
21927815-1	2012	Human endothelial nitric oxide synthase (eNOS) is one isoform of the nitric oxide synthases that are responsible for nitric oxide synthesis from L-arginine.	Arginine	145-155	nitric oxide synthase 3	Homo sapiens	41-45
22103682-7	2012	We further demonstrate that the C-terminal glycine-arginine rich domain of nucleolin serves as the predominant binding domain for direct interaction with p53.	Arginine	51-59	tumor protein p53	Homo sapiens	154-157
22103682-9	2012	Conversely, the adjacent glycine-arginine rich domain of nucleolin interacted with p53 causing a modest stimulatory effect on p53 ubiquitination.	Arginine	33-41	tumor protein p53	Homo sapiens	83-86
22103682-9	2012	Conversely, the adjacent glycine-arginine rich domain of nucleolin interacted with p53 causing a modest stimulatory effect on p53 ubiquitination.	Arginine	33-41	tumor protein p53	Homo sapiens	126-129
22269954-5	2012	We separately studied four patients who were diagnosed with GHD according to the GHRH-arginine test.	Arginine	86-94	growth hormone releasing hormone	Homo sapiens	81-85
22089129-7	2012	In the present study we identified a G to C nucleotide exchange in exon 15 of the Atp7a gene in mosaic mutants, which resulted in an arginine to proline substitution in the highly conserved 6th transmembrane domain of the ATP7A protein.	Arginine	133-141	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	82-87
21740101-2	2012	To date, several potent DDAH inhibitors have been published, most of them representing analogues of l-arginine.	Arginine	100-110	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	24-28
22033378-10	2012	More striking is the role played by L-arginine as substrate for nitric oxide synthase (NOS2) in macrophages, the main route of clearance of many infectious agents including Leishmania and Trypanosoma cruzi.	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	87-91
22033378-11	2012	In infected macrophages L-arginine is catalysed by NOS2 or arginase, contributing to host defense or parasite killing, respectively.	Arginine	24-34	nitric oxide synthase 2	Homo sapiens	51-55
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	137-145	tumor protein p53	Homo sapiens	115-118
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	137-145	tumor protein p53	Homo sapiens	239-242
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	147-150	tumor protein p53	Homo sapiens	115-118
21607615-2	2012	A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	147-150	tumor protein p53	Homo sapiens	239-242
22089129-7	2012	In the present study we identified a G to C nucleotide exchange in exon 15 of the Atp7a gene in mosaic mutants, which resulted in an arginine to proline substitution in the highly conserved 6th transmembrane domain of the ATP7A protein.	Arginine	133-141	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	222-227
22156497-6	2012	Notably, we discovered that an unusual RKR motif (Arg(39)-Lys(40)-Arg(41)), conserved only in GzmH, helps define the S3" and S4" binding regions, indicating the preference for acidic residues at the P3" and P4" sites.	Arginine	50-53	granzyme H	Homo sapiens	94-98
22213184-6	2012	This approach was examined by incorporating arginine mimetics into ligands for the Src, Grb, and Crk SH3 domains at the site of the key recognition arginine.	Arginine	44-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-86
22213184-6	2012	This approach was examined by incorporating arginine mimetics into ligands for the Src, Grb, and Crk SH3 domains at the site of the key recognition arginine.	Arginine	44-52	CRK proto-oncogene, adaptor protein	Homo sapiens	97-100
22213184-6	2012	This approach was examined by incorporating arginine mimetics into ligands for the Src, Grb, and Crk SH3 domains at the site of the key recognition arginine.	Arginine	148-156	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-86
22213184-6	2012	This approach was examined by incorporating arginine mimetics into ligands for the Src, Grb, and Crk SH3 domains at the site of the key recognition arginine.	Arginine	148-156	CRK proto-oncogene, adaptor protein	Homo sapiens	97-100
22213184-8	2012	We demonstrate that paralogue specificity and target site affinity may be modulated with the use of alpha-guanidino acid-derived arginine mimetics, generating peptides that exhibit enhanced Src specificity by selection against Grb and peptides that reverse the specificity of the native peptide ligand, with enhancements in Src target specificity of up to 15-fold (1.6 kcal mol(-1)).	Arginine	129-137	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	190-193
22213184-8	2012	We demonstrate that paralogue specificity and target site affinity may be modulated with the use of alpha-guanidino acid-derived arginine mimetics, generating peptides that exhibit enhanced Src specificity by selection against Grb and peptides that reverse the specificity of the native peptide ligand, with enhancements in Src target specificity of up to 15-fold (1.6 kcal mol(-1)).	Arginine	129-137	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	324-327
22156497-6	2012	Notably, we discovered that an unusual RKR motif (Arg(39)-Lys(40)-Arg(41)), conserved only in GzmH, helps define the S3" and S4" binding regions, indicating the preference for acidic residues at the P3" and P4" sites.	Arginine	66-69	granzyme H	Homo sapiens	94-98
22052904-6	2012	Consistent with such a role, robust binding to native nucleosomes is observed when LBR-TD is extended toward its carboxyl terminus, to include an area rich in Ser-Arg residues.	Arginine	163-166	lamin B receptor	Homo sapiens	83-86
20641959-20	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	143-153
22289634-1	2012	Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution.	Arginine	77-85	tumor protein p53	Homo sapiens	6-10
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Arginine	44-53	zinc finger and BTB domain containing 17	Homo sapiens	80-84
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Arginine	44-53	tumor necrosis factor	Homo sapiens	124-133
22184250-5	2012	Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation.	Arginine	44-53	mitogen-activated protein kinase 8	Homo sapiens	142-146
22901123-7	2012	RESULTS: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22).	Arginine	73-76	tumor protein p53	Homo sapiens	69-72
22901183-5	2012	RESULTS: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737).	Arginine	47-50	poly(ADP-ribose) polymerase 1	Homo sapiens	176-181
22404633-3	2012	NO is synthesized from l-arginine and oxygen (O(2)) by the enzyme nitric oxide synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	66-87
22502699-2	2012	A common single nucleotide polymorphism located within the proline rich region of TP53 gene at codon 72 in exon 4 encodes either proline or arginine.	Arginine	140-148	tumor protein p53	Homo sapiens	82-86
22502699-3	2012	TP53 Arg 72 is more active than TP53 Pro 72 in inducing apoptosis.	Arginine	5-8	tumor protein p53	Homo sapiens	0-4
22901123-7	2012	RESULTS: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22).	Arginine	123-126	tumor protein p53	Homo sapiens	69-72
22901123-7	2012	RESULTS: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22).	Arginine	123-126	tumor protein p53	Homo sapiens	69-72
22901126-2	2012	Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP.	Arginine	34-37	tumor protein p53	Homo sapiens	58-61
22056509-0	2012	Phosphorylation of the arginine/serine repeats of lamin B receptor by SRPK1-insights from molecular dynamics simulations.	Arginine	23-31	lamin B receptor	Homo sapiens	50-66
21948347-5	2012	Simulations with lysozyme and insulin also show arginine"s preference for aromatic residues, in addition to acidic residues.	Arginine	48-56	insulin	Homo sapiens	30-37
23275693-5	2012	The involvement of residues like LYS-591, ARG-609, SER-611, GLU-612, SER-613, SER-636 and VAL-637 seems to play an important role in binding of curcumin natural derivatives and its amino acids conjugates with Src Homology (SH2) domain of Stat3 monomer.	Arginine	42-45	signal transducer and activator of transcription 3	Homo sapiens	238-243
21922321-8	2012	Arginine-stimulated (p = 0.02) insulin secretion was reduced in vivo, which was further reflected by a reduction of glucose- and potassium-stimulated insulin secretion (p = 0.002 and p = 0.04, respectively) in human islets in vitro.	Arginine	0-8	insulin	Homo sapiens	31-38
22785485-6	2012	This is the first report that the ADMA-metabolizing system, including the arginine methylation of proteins and the breakdown of free ADMA, occurs in circulating blood cell-populations, and that catalase in ECs might be a potential protein targeted by PRMT1.	Arginine	74-82	catalase	Rattus norvegicus	194-202
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Arginine	296-304	l(2)46Co	Drosophila melanogaster	374-381
22182433-4	2012	The coding region of ECM1 was amplified and sequenced, and a novel homozygous single-nucleotide substitution, c.1429T&gt;C, was found in exon 9, which converts cysteine to arginine, designated p.C477R.	Arginine	172-180	extracellular matrix protein 1	Homo sapiens	21-25
21922321-8	2012	Arginine-stimulated (p = 0.02) insulin secretion was reduced in vivo, which was further reflected by a reduction of glucose- and potassium-stimulated insulin secretion (p = 0.002 and p = 0.04, respectively) in human islets in vitro.	Arginine	0-8	insulin	Homo sapiens	150-157
23056045-0	2012	Arginine 16 Glycine Polymorphism in beta2-Adrenergic Receptor Gene is Associated with Obesity, Hyperlipidemia, Hyperleptinemia, and Insulin Resistance in Saudis.	Arginine	0-8	insulin	Homo sapiens	132-139
21965298-0	2012	Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.	Arginine	0-8	FUS RNA binding protein	Homo sapiens	89-96
21965298-9	2012	We propose that arginine methylation by PRMT1 participates in the nuclear-cytoplasmic shuttling of FUS, particularly of ALS6-associated mutants, and thus contributes to the toxic gain of function conferred by these disease-causing mutations.	Arginine	16-24	FUS RNA binding protein	Homo sapiens	120-124
22991499-9	2012	The results indicate that in certain RCC cell lines, IFNgamma modulates L-arginine metabolism by shifting from arginase to iNOS activity, thereby developing a potent inhibitory mechanism to encumber tumor cell proliferation and survival.	Arginine	72-82	interferon gamma	Mus musculus	53-61
22991499-9	2012	The results indicate that in certain RCC cell lines, IFNgamma modulates L-arginine metabolism by shifting from arginase to iNOS activity, thereby developing a potent inhibitory mechanism to encumber tumor cell proliferation and survival.	Arginine	72-82	nitric oxide synthase 2, inducible	Mus musculus	123-127
22991499-10	2012	Elucidating the cellular events triggered by IFNgamma in murine RCC cell lines will permit anti-tumor effects to be exploited in the development of new combination therapies that interfere with L-arginine metabolism to effectively combat RCC in patients.	Arginine	194-204	interferon gamma	Mus musculus	45-53
22100383-3	2012	In the N-terminal lobe, the anion-binding residue Arg was substituted with Lys, which represents a common feature in fish and implies a selective preference in the transferrin evolutionary process.	Arginine	50-53	transferrin	Homo sapiens	164-175
21311889-9	2012	While the resting tension of the right atrium was decreased by the NO precursor L-arginine (1-100 muM), it was increased by the nitric oxide synthase inhibitor L-NMMA (0.1-100 muM).	Arginine	80-90	latexin	Homo sapiens	98-101
22210716-9	2012	Our study indicated that a high prevalence of the genotype Arg/Pro at the p53 codon 72 may contribute to susceptibility to OSCC, especially in combination with the use of carcinogenic tobacco-specific nitrosamine (TSNA)-rich toombak.	Arginine	59-62	tumor protein p53	Homo sapiens	74-77
22619531-5	2012	PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles.	Arginine	84-92	fibronectin 1	Homo sapiens	64-75
23109853-1	2012	l-Arginine (Arg) is oxidized to l-citrulline and nitric oxide (NO) by the action of endothelial nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	84-117
23109853-1	2012	l-Arginine (Arg) is oxidized to l-citrulline and nitric oxide (NO) by the action of endothelial nitric oxide synthase (NOS).	Arginine	2-5	nitric oxide synthase 3	Homo sapiens	84-117
22489133-9	2012	Furthermore, methylation potential of human FoxO3 at arginine and lysine residues and crosstalk between methylation and phosphorylation have also been described.	Arginine	53-61	forkhead box O3	Homo sapiens	44-49
21972205-2	2012	Based on the antibody-protein adhesive force maps and phase imaging, it was found that the nanomorphology of the triblock copolymer is conducive to the exposure of the arginine-glycine-aspartic acid (RGD) groups in Fn.	Arginine	168-176	fibronectin 1	Homo sapiens	215-217
22513384-6	2012	Next, we incubated CADM1-targeted and non-targeted alphaTC6 cells in a medium containing 1 mM glucose and 200 mM arginine for 30 min to induce glucagon secretion, and found that the targeted cells secreted three times more glucagon than did the non-targeted.	Arginine	113-121	cell adhesion molecule 1	Mus musculus	19-24
23133647-3	2012	This is in contrast to mutations within a heparin-binding TB domain (TB5), which is downstream of the arg-gly-asp cell adhesion domain, which can cause Weill-Marchesani syndrome (WMS) or Acromicric (AD) and Geleophysic Dysplasias (GD).	Arginine	102-105	transforming growth factor beta regulator 1	Homo sapiens	69-72
22613405-1	2012	OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial.	Arginine	137-145	tumor protein p53	Homo sapiens	79-82
22613405-1	2012	OBJECTIVE: The association between codon 72 polymorphism of the tumour protein p53 (TP53) gene - which results in a missense mutation of arginine (R) to proline (P) - and susceptibility to hepatocellular carcinoma (HCC) is controversial.	Arginine	137-145	tumor protein p53	Homo sapiens	84-88
23075551-3	2012	L-Arginine is the main precursor of NO via nitric oxide synthase (NOS) activity.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	43-64
23152885-0	2012	The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS.	Arginine	29-37	FUS RNA binding protein	Homo sapiens	138-145
23152885-4	2012	The modulation of arginine methylation levels by a general methyltransferase inhibitor or conditional over-expression of PRMT1 altered slightly the nucleus-cytoplasmic ratio of FUS/TLS in cell fractionation assays.	Arginine	18-26	FUS RNA binding protein	Homo sapiens	177-184
23152885-8	2012	These findings indicate that PRMT1-mediated arginine methylation could be implicated in the nucleus-cytoplasmic shuttling of FUS/TLS and in the SGs formation and the detergent-insoluble inclusions of ALS-linked FUS/TLS mutants.	Arginine	44-52	FUS RNA binding protein	Homo sapiens	125-132
23152885-8	2012	These findings indicate that PRMT1-mediated arginine methylation could be implicated in the nucleus-cytoplasmic shuttling of FUS/TLS and in the SGs formation and the detergent-insoluble inclusions of ALS-linked FUS/TLS mutants.	Arginine	44-52	FUS RNA binding protein	Homo sapiens	211-218
23155712-0	2012	Self-limiting hematuria following growth hormone provocative testing with arginine hydrochloride.	Arginine	74-96	growth hormone 1	Homo sapiens	34-48
22738901-2	2012	IFNT also acts with P4 to induce expression of genes for transport of nutrients, such as glucose (Gluc) and arginine (Arg) into the uterine lumen to activate mechanistic mammalian target of rapamycin (MTOR) cell signaling that stimulates proliferation, migration, gene transcription and mRNA translation by conceptus trophectoderm (Tr).	Arginine	108-116	mechanistic target of rapamycin kinase	Homo sapiens	170-199
22738901-2	2012	IFNT also acts with P4 to induce expression of genes for transport of nutrients, such as glucose (Gluc) and arginine (Arg) into the uterine lumen to activate mechanistic mammalian target of rapamycin (MTOR) cell signaling that stimulates proliferation, migration, gene transcription and mRNA translation by conceptus trophectoderm (Tr).	Arginine	108-116	mechanistic target of rapamycin kinase	Homo sapiens	201-205
22738901-2	2012	IFNT also acts with P4 to induce expression of genes for transport of nutrients, such as glucose (Gluc) and arginine (Arg) into the uterine lumen to activate mechanistic mammalian target of rapamycin (MTOR) cell signaling that stimulates proliferation, migration, gene transcription and mRNA translation by conceptus trophectoderm (Tr).	Arginine	118-121	mechanistic target of rapamycin kinase	Homo sapiens	170-199
22738901-2	2012	IFNT also acts with P4 to induce expression of genes for transport of nutrients, such as glucose (Gluc) and arginine (Arg) into the uterine lumen to activate mechanistic mammalian target of rapamycin (MTOR) cell signaling that stimulates proliferation, migration, gene transcription and mRNA translation by conceptus trophectoderm (Tr).	Arginine	118-121	mechanistic target of rapamycin kinase	Homo sapiens	201-205
22738901-5	2012	Arg increases expression of GTP cyclohydrolase 1 (GCH1) and IFNT mRNAs while Arg and Gluc increase ornithine decarboxylase, nitric oxide synthase 2, and GCH1 mRNAs and proteins by Tr cells.	Arginine	77-80	ornithine decarboxylase 1	Sus scrofa	99-122
22738901-5	2012	Arg increases expression of GTP cyclohydrolase 1 (GCH1) and IFNT mRNAs while Arg and Gluc increase ornithine decarboxylase, nitric oxide synthase 2, and GCH1 mRNAs and proteins by Tr cells.	Arginine	77-80	nitric oxide synthase 2	Sus scrofa	124-147
22738901-11	2012	Arg and Leu increase MTOR cell signaling and proliferation of pig Tr, as do Gluc and fructose.	Arginine	0-3	mechanistic target of rapamycin kinase	Sus scrofa	21-25
22815628-7	2012	A C&gt;T substitution at codon 240 converts an arginine codon (CGA) to a termination codon (TGA).The same mutation was detected in the sporadic patient by chance.	Arginine	47-55	chromogranin A	Homo sapiens	63-66
22862164-1	2012	Nitric oxide (NO), is endogenously synthesized from L-arginine by nitric oxide synthase (NOS), exhibits a dual role in sensitivity to radiotherapy and chemotherapy of cancer cells.	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	66-87
22100620-8	2012	The differential specificities of CRTAase to PA were found to positively correlate with increased production of NO upon incubation of PRP with PA and l-arginine.	Arginine	150-160	complement component 4 binding protein alpha	Homo sapiens	134-137
21935580-0	2012	Arginine 482 to glycine mutation in ABCG2/BCRP increases etoposide transport             and resistance to the drug in HEK-293 cells.	Arginine	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	36-41
21935580-0	2012	Arginine 482 to glycine mutation in ABCG2/BCRP increases etoposide transport             and resistance to the drug in HEK-293 cells.	Arginine	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	42-46
22814004-1	2012	L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both in vitro and in vivo, with N(omega)-nitro-L-arginine methyl ester (L-NAME) being at the head.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	51-72
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Arginine	56-59	tumor protein p53	Homo sapiens	25-29
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Arginine	60-63	tumor protein p53	Homo sapiens	25-29
23071787-7	2012	The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered.	Arginine	137-140	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
23049825-3	2012	In this study we evaluate the association between a p53 variant functionally known to influence apoptosis (codon 72 Pro/Arg) and the subset of primary open angle glaucoma (POAG) patients with early loss of central visual field.	Arginine	120-123	tumor protein p53	Homo sapiens	52-55
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Arginine	60-63	tumor protein p53	Homo sapiens	25-29
23071787-6	2012	The frequency of somatic TP53 inactivation was 25.4% in Arg/Arg, 20.9% in Arg/Pro, and 16.7% in Pro/Pro patients, which may reflect a higher selective pressure to mutate the Arg-allele.	Arginine	60-63	tumor protein p53	Homo sapiens	25-29
23071787-7	2012	The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered.	Arginine	133-136	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
23049825-4	2012	METHODS: Genotypes for the p53 codon 72 polymorphism (Pro/Arg) were obtained for 264 POAG patients and 400 controls from the U.S. and in replication studies for 308 POAG patients and 178 controls from Australia (GIST).	Arginine	58-61	tumor protein p53	Homo sapiens	27-30
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Arginine	26-35	cyclin-dependent kinase 4	Mus musculus	85-89
22916108-1	2012	PRMT6 belongs to the family of Protein Arginine Methyltransferase (PRMT) enzymes that catalyze the methylation of guanidino nitrogens of arginine residues.	Arginine	137-145	protein arginine methyltransferase 6	Homo sapiens	0-5
22916108-7	2012	Our findings imply arginine methylation of histones by PRMT6 in cell cycle regulation.	Arginine	19-27	protein arginine methyltransferase 6	Homo sapiens	55-60
22844517-0	2012	Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium.	Arginine	18-28	insulin	Homo sapiens	0-7
22911765-8	2012	Further, ChIP analysis of two of the most highly up- and down-regulated genes (PTN and MAGEA12, respectively) found that PAD2 binds directly to these gene promoters and that the likely mechanism by which PAD2 regulates expression of these genes is via citrullination of arginine residues 2-8-17 on histone H3 tails.	Arginine	270-278	pleiotrophin	Homo sapiens	79-82
22844517-4	2012	However, whether A(2A)AR plays a role in insulin-mediated increase in L-arginine transport in HUVECs is unknown.	Arginine	70-80	insulin	Homo sapiens	41-48
22844517-7	2012	Insulin and NBTI increased the extracellular adenosine concentration, the maximal velocity for L-arginine transport without altering the apparent K(m) for L-arginine transport, hCAT-1 protein and mRNA expression levels, and SLC7A1 transcriptional activity.	Arginine	95-105	insulin	Homo sapiens	0-7
22693611-6	2012	In vitro studies revealed that COUP-TFII interacts with the C-terminal arginine-glycine repeat (RGG) domain of nucleolin.	Arginine	71-79	nuclear receptor subfamily 2 group F member 2	Homo sapiens	31-40
22848442-9	2012	In trophoblast JAR cells, treatment with arginine and its metabolites enhanced Stat3, PKB, and S6K1 activation and facilitated cellular adhesion activity.	Arginine	41-49	signal transducer and activator of transcription 3	Homo sapiens	79-84
22808006-7	2012	These dibasic amino acids share plasma membrane transporters with arginine, the rate-limiting substrate for nitric oxide synthase (NOS), a critical mediator of cardiovascular health.	Arginine	66-74	nitric oxide synthase 2	Homo sapiens	108-129
22701565-3	2012	The latter include members of three different families of proteins: the well characterized arginine-specific ecto-enzymes ARTCs, two sirtuins and, more recently, novel members of the poly(ADP-ribose) polymerase (PARP/ARTD) family that have been suggested to act as cellular mono-ADP-ribosyltransferases.	Arginine	91-99	poly(ADP-ribose) polymerase 1	Homo sapiens	212-216
22666345-7	2012	However, processes such as RNA processing, cellular metal ion homeostasis and protein transport and were enriched in genes up-regulated under cold exposure for 48 h. Pathways such as mTOR signalling, p53 signalling and circadian rhythm were enriched among cold-induced genes, while adipocytokine signalling, protein export and arginine and praline metabolism were enriched among heat-induced genes.	Arginine	327-335	mechanistic target of rapamycin kinase	Danio rerio	183-187
22701565-3	2012	The latter include members of three different families of proteins: the well characterized arginine-specific ecto-enzymes ARTCs, two sirtuins and, more recently, novel members of the poly(ADP-ribose) polymerase (PARP/ARTD) family that have been suggested to act as cellular mono-ADP-ribosyltransferases.	Arginine	91-99	poly(ADP-ribose) polymerase 1	Homo sapiens	183-210
22666356-12	2012	Jejunal tissues in the L-Citrulline-supplemented group showed, compared to the endotoxemic and L-Arginine-supplemented endotoxemic group, an increase in degree of phosphorylation of eNOS (Ser 1177) and a decrease in iNOS protein level.	Arginine	95-105	nitric oxide synthase 2, inducible	Mus musculus	216-220
22403718-4	2012	Simulations of HLA:peptide systems suggest that peptide-stabilizing interactions of the Arg62 residue observed in crystal structures are metastable for both B27 subtypes under physiological conditions, rendering this arginine solvent-exposed and, probably, a key residue for TCR interaction more than peptide-binding.	Arginine	217-225	melanocortin 2 receptor accessory protein	Homo sapiens	157-160
22428068-9	2012	Because CAT2 induction was sustained during L-Arg treatment and inducible nitric oxide (NO) synthase (iNOS) requires uptake of L-Arg for generation of NO, we tested the effect of L-Arg in iNOS(-/-) mice and found that its benefits in DSS colitis were eliminated.	Arginine	127-132	nitric oxide synthase 2, inducible	Mus musculus	102-106
22428068-9	2012	Because CAT2 induction was sustained during L-Arg treatment and inducible nitric oxide (NO) synthase (iNOS) requires uptake of L-Arg for generation of NO, we tested the effect of L-Arg in iNOS(-/-) mice and found that its benefits in DSS colitis were eliminated.	Arginine	127-132	nitric oxide synthase 2, inducible	Mus musculus	102-106
22848454-3	2012	Gating of murine P2X7 can be induced by the soluble ligand ATP, as well as by NAD(+)-dependent ADP-ribosylation of arginine 125, a posttranslational protein modification catalyzed by the toxin-related ecto-enzymes ART2.1 and ART2.2.	Arginine	115-123	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	17-21
22363433-3	2012	Recently, TDRD3 was shown to be a transcriptional coactivator, and its transcriptional activity is dependent on its ability to bind arginine-methylated histone marks.	Arginine	132-140	tudor domain containing 3	Homo sapiens	10-15
22253860-7	2012	The overall best model by MDR was tobacco habit/p53(Arg/Arg)/XRCC1(Arg399His)/mEH(Tyr113His) that had highest Cross Validation Consistency (8.3) and test accuracy (0.69).	Arginine	52-55	epoxide hydrolase 1, microsomal	Mus musculus	78-81
22395499-10	2012	Frequency of Arg/Arg genotype of p53 gene was higher among cases (43%) compared with controls (33.3%), but the difference was not statistically significant (p=0.75).	Arginine	13-16	tumor protein p53	Homo sapiens	33-36
22395499-10	2012	Frequency of Arg/Arg genotype of p53 gene was higher among cases (43%) compared with controls (33.3%), but the difference was not statistically significant (p=0.75).	Arginine	17-20	tumor protein p53	Homo sapiens	33-36
22363433-5	2012	Our results show that TDRD3 preferentially recognizes asymmetrical dimethylated arginine mark, and SMN is a very promiscuous effector molecule, which recognizes different arginine containing sequence motifs and preferentially binds symmetrical dimethylated arginine.	Arginine	80-88	tudor domain containing 3	Homo sapiens	22-27
22864347-8	2012	M1-GM3S is stably localized in the endoplasmic reticulum (ER), as a result of retrograde transport signals (arginine [R]-based motifs); consequently, its in vivo GM3 synthesis activity is very low compared with that of other isoforms.	Arginine	108-116	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	3-7
22143770-0	2011	Structural insights into protein arginine symmetric dimethylation by PRMT5.	Arginine	33-41	protein arginine methyltransferase 5	Homo sapiens	69-74
22500392-3	2012	RESULTS: There was significant difference in the frequency of the genotype Arg/Gln + Gln/Gln in the TLR2 Arg753Gln genetic polymorphisms [26.	Arginine	75-78	toll like receptor 2	Homo sapiens	100-104
22143770-4	2011	Changing it to a methionine significantly elevates the overall methylase activity, but also converts PRMT5 to an enzyme that catalyzes both symmetric and asymmetric dimethylation of arginine.	Arginine	182-190	protein arginine methyltransferase 5	Homo sapiens	101-106
21982800-6	2011	Subjects with the p53 Arg/Pro + Pro/Pro genotype or MDM2 SNP309 TG+GG genotype, in conjunction with high urinary total arsenic (&gt;=14.02mug/L), had a signicantly higher RCC risk than those with the p53 Arg/Arg or MDM2 SNP309 TT genotypes and low urinary total arsenic.	Arginine	22-25	tumor protein p53	Homo sapiens	18-21
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Arginine	189-192	actin	Saccharomyces cerevisiae S288C	74-79
22020933-5	2011	NHE1-phosphoinositide binding was enhanced by acidic pH, and abolished by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic interactions.	Arginine	79-82	solute carrier family 9 member A1	Homo sapiens	0-4
22020933-5	2011	NHE1-phosphoinositide binding was enhanced by acidic pH, and abolished by NHE1 Arg/Lys to Ala mutations within two juxtamembrane domains, consistent with electrostatic interactions.	Arginine	79-82	solute carrier family 9 member A1	Homo sapiens	74-78
21914450-8	2011	Simvastatin induced an increase in eNOS mRNA expression and protein levels in the presence of arginine or citrulline.	Arginine	94-102	nitric oxide synthase 3	Bos taurus	35-39
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Arginine	189-192	actin	Saccharomyces cerevisiae S288C	32-37
21958471-8	2011	Interestingly, complementing Lactobacillus with arginine revealed a synergistic decrease not only in the liver markers but also in NO and TNF-alpha along with increased intensity of ornithine and methionine.	Arginine	48-56	tumor necrosis factor	Rattus norvegicus	138-147
21958548-1	2011	Inducible nitric oxide synthase (iNOS) catalyzes the reaction that converts the substrates O(2) and l-arginine to the products nitric oxide (NO) and l-citrulline.	Arginine	100-110	nitric oxide synthase 2	Homo sapiens	0-31
21958548-1	2011	Inducible nitric oxide synthase (iNOS) catalyzes the reaction that converts the substrates O(2) and l-arginine to the products nitric oxide (NO) and l-citrulline.	Arginine	100-110	nitric oxide synthase 2	Homo sapiens	33-37
21831234-1	2011	Nitric oxide (NO) is produced via oxidation of l-arginine by nitric oxide synthases (NOSs), and is known as inducible (iNOS), neuronal, endothelial or testis-specific.	Arginine	47-57	nitric oxide synthase 2, inducible	Mus musculus	119-123
22014686-2	2011	Factors in physiological fluids that regulate the chemotactic activity of complement activation peptides C5a and C5a des Arg are not well understood.	Arginine	121-124	complement C5a receptor 1	Homo sapiens	113-116
22014686-3	2011	The vitamin D binding protein (DBP) has been shown to significantly enhance chemotaxis to C5a/C5a des Arg.	Arginine	102-105	D-box binding PAR bZIP transcription factor	Homo sapiens	31-34
22014686-3	2011	The vitamin D binding protein (DBP) has been shown to significantly enhance chemotaxis to C5a/C5a des Arg.	Arginine	102-105	complement C5a receptor 1	Homo sapiens	90-93
22014686-3	2011	The vitamin D binding protein (DBP) has been shown to significantly enhance chemotaxis to C5a/C5a des Arg.	Arginine	102-105	complement C5a receptor 1	Homo sapiens	94-97
22014686-12	2011	The results clearly demonstrate that C5a/C5a des Arg needs both DBP and TSP-1 for maximal chemotactic activity and suggest that the regulation of C5a chemotactic activity in physiological fluids is more complex than previously thought.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	37-40
22014686-12	2011	The results clearly demonstrate that C5a/C5a des Arg needs both DBP and TSP-1 for maximal chemotactic activity and suggest that the regulation of C5a chemotactic activity in physiological fluids is more complex than previously thought.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
22014686-12	2011	The results clearly demonstrate that C5a/C5a des Arg needs both DBP and TSP-1 for maximal chemotactic activity and suggest that the regulation of C5a chemotactic activity in physiological fluids is more complex than previously thought.	Arginine	49-52	D-box binding PAR bZIP transcription factor	Homo sapiens	64-67
22014686-12	2011	The results clearly demonstrate that C5a/C5a des Arg needs both DBP and TSP-1 for maximal chemotactic activity and suggest that the regulation of C5a chemotactic activity in physiological fluids is more complex than previously thought.	Arginine	49-52	thrombospondin 1	Homo sapiens	72-77
22014686-12	2011	The results clearly demonstrate that C5a/C5a des Arg needs both DBP and TSP-1 for maximal chemotactic activity and suggest that the regulation of C5a chemotactic activity in physiological fluids is more complex than previously thought.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
21875681-1	2011	The production of nitric oxide (NO) from l-arginine is catalyzed by NO synthase (NOS), which exists as the following three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	41-51	nitric oxide synthase 2	Rattus norvegicus	185-189
21967851-0	2011	Manipulating the proximal triad His-Asn-Arg in human myeloperoxidase.	Arginine	40-43	myeloperoxidase	Homo sapiens	53-68
21923750-3	2011	L-arginine (L-arg) is the substrate for NO synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	40-51
21923750-3	2011	L-arginine (L-arg) is the substrate for NO synthase (NOS).	Arginine	0-5	nitric oxide synthase 2	Homo sapiens	40-51
21858699-1	2011	The possible hydrolysis of substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met) in presence of the osteoblastic cell line SaOS-2 was measured by capillary electrophoresis coupled to mass detection.	Arginine	40-43	tachykinin precursor 1	Homo sapiens	27-38
22153010-0	2011	[L-arginine suppresses ischemia/reperfusion induced up-regulation of endothelin-1 production in a rat model of acute myocardial injury].	Arginine	1-11	endothelin 1	Rattus norvegicus	69-81
22153010-7	2011	administration of L-Arg significantly suppressed the up-regulation of tissue content of ET-1 mRNA /peptide in I/R treated animals (ET-1 mRNA: 0.340 +- 0.049 vs. 0.775 +- 0.029; ET-1 peptide: 0.390 +- 0.094 vs. 0.773 +- 0.055, both P &lt; 0.05).	Arginine	18-23	endothelin 1	Rattus norvegicus	88-92
22153010-7	2011	administration of L-Arg significantly suppressed the up-regulation of tissue content of ET-1 mRNA /peptide in I/R treated animals (ET-1 mRNA: 0.340 +- 0.049 vs. 0.775 +- 0.029; ET-1 peptide: 0.390 +- 0.094 vs. 0.773 +- 0.055, both P &lt; 0.05).	Arginine	18-23	endothelin 1	Rattus norvegicus	131-135
22153010-7	2011	administration of L-Arg significantly suppressed the up-regulation of tissue content of ET-1 mRNA /peptide in I/R treated animals (ET-1 mRNA: 0.340 +- 0.049 vs. 0.775 +- 0.029; ET-1 peptide: 0.390 +- 0.094 vs. 0.773 +- 0.055, both P &lt; 0.05).	Arginine	18-23	endothelin 1	Rattus norvegicus	131-135
22153010-8	2011	CONCLUSION: L-Arg may be tested during certain stage of I/R injury as a therapeutic intervention for the suppression of ET-1 up-regulation.	Arginine	12-17	endothelin 1	Rattus norvegicus	120-124
21914450-10	2011	Combining statin with arginine or citrulline increased NO production in endothelial cells by increasing eNOS protein levels.	Arginine	22-30	nitric oxide synthase 3	Bos taurus	104-108
21986532-1	2011	We examined the relative contributory roles of extracellular vs. intracellular L-arginine (ARG) toward cellular activation of endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Arginine	79-89	nitric oxide synthase 3	Homo sapiens	126-159
21921039-1	2011	Nitric-oxide synthases (NOS) are heme-thiolate enzymes that generate nitric oxide (NO) from L-arginine.	Arginine	92-102	nitric oxide synthase 2	Homo sapiens	0-22
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Arginine	79-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-108
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Arginine	79-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-178
21986532-1	2011	We examined the relative contributory roles of extracellular vs. intracellular L-arginine (ARG) toward cellular activation of endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Arginine	91-94	nitric oxide synthase 3	Homo sapiens	126-159
21986532-10	2011	It is likely that once transported inside the cell, ARG can no longer gain access to the membrane-bound eNOS.	Arginine	52-55	nitric oxide synthase 3	Homo sapiens	104-108
21986532-1	2011	We examined the relative contributory roles of extracellular vs. intracellular L-arginine (ARG) toward cellular activation of endothelial nitric oxide synthase (eNOS) in human endothelial cells.	Arginine	91-94	nitric oxide synthase 3	Homo sapiens	161-165
21839088-3	2011	Our previous data with human umbilical vein (HUVEC) and EA.hy.926 endothelial cells demonstrated that eNOS can obtain its substrate from the conversion of l-citrulline to l-arginine and from protein breakdown.	Arginine	171-181	nitric oxide synthase 3	Homo sapiens	102-106
21649863-11	2011	CONCLUSION: Intact renal L-arginine transport attenuates the vasoconstrictor effects of circulating angiotensin II in the renal cortex in SD rats.	Arginine	25-35	angiotensinogen	Rattus norvegicus	100-114
21649863-12	2011	L-arginine also plays an important role in protecting the renal medullary circulation from the ischemic effects of angiotensin II in Dahl S rats.	Arginine	0-10	angiotensinogen	Rattus norvegicus	115-129
21852363-9	2011	Arginine increased TGF-beta1 (185 +- 40 vs. 15 +- 2 ng/ml; P &lt;0.01) that was blunted by TRF (53 +- 19; P &lt; 0.01).	Arginine	0-8	transforming growth factor beta 1	Homo sapiens	19-28
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Arginine	47-50	tumor protein p53	Homo sapiens	19-22
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
21595775-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in EC were 39.4%, 45.6%, and 15.0%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively.	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
21302286-1	2011	Insulin causes endothelium-derived nitric oxide (NO)-dependent vascular relaxation, and increases L-arginine transport via cationic amino acid transporter 1 (hCAT-1) and endothelial NO synthase (eNOS) expression and activity in human umbilical vein endothelium (HUVEC).	Arginine	98-108	insulin	Homo sapiens	0-7
21302286-7	2011	Insulin increased hCATs-L-arginine transport, maximal transport capacity (V(max) /K(m) ), and hCAT-1 expression.	Arginine	24-34	insulin	Homo sapiens	0-7
21302286-11	2011	Insulin increased NO synthesis and caused endothelium-dependent vessel relaxation and reduced U46619-induced contraction, effects blocked by NEM and L-lysine, and dependent on extracellular L-arginine.	Arginine	190-200	insulin	Homo sapiens	0-7
21302286-12	2011	We suggest that insulin induces human umbilical vein relaxation by increasing HUVEC L-arginine transport via hCATs (likely hCAT-1) most likely requiring Sp1-activated SLC7A1 expression.	Arginine	84-94	insulin	Homo sapiens	16-23
21839088-0	2011	Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase.	Arginine	35-45	nitric oxide synthase 3	Homo sapiens	81-114
21649863-0	2011	Role of L-arginine uptake mechanisms in renal blood flow responses to angiotensin II in rats.	Arginine	8-18	angiotensinogen	Rattus norvegicus	70-84
21302286-0	2011	Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation.	Arginine	19-29	insulin	Homo sapiens	0-7
21900158-4	2011	The major distinction of SLA-1 0401 is that Arg(156) has a "one-ballot veto" function in peptide binding, due to its flexible side chain.	Arginine	44-47	MHC class I antigen 1	Sus scrofa	25-30
21465165-1	2011	The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial.	Arginine	73-81	paraoxonase 1	Homo sapiens	29-33
21465165-8	2011	We found a significant association between the PON1-Arg-192 genotype (QR + RR) and the extent of CAD in CAD patients and CAD subjects without diabetes, represented by the increased frequency of three-vessel disease with OR = 1.49, P = 0.046; chi2 = 3.82, P = 0.048 and OR = 1.46, P = 0.05; chi2 = 3.48, P = 0.051, respectively.	Arginine	52-55	paraoxonase 1	Homo sapiens	47-51
21465165-9	2011	The CAD patients carrying PON1-Arg-192 genotype (QR + RR) had lower plasma HDL-C level (P = 0.019) and higher plasma LDL-C(P = 0.01) and TG(P = 0.05).	Arginine	31-34	paraoxonase 1	Homo sapiens	26-30
21465165-10	2011	Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile.	Arginine	32-35	paraoxonase 1	Homo sapiens	27-31
21465165-10	2011	Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile.	Arginine	32-35	paraoxonase 1	Homo sapiens	142-146
21465165-10	2011	Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile.	Arginine	147-150	paraoxonase 1	Homo sapiens	27-31
21465165-10	2011	Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile.	Arginine	147-150	paraoxonase 1	Homo sapiens	142-146
21839088-8	2011	eNOS activity was fully restored by supplementing either l-citrulline or l-arginine-containing dipeptides.	Arginine	73-83	nitric oxide synthase 3	Homo sapiens	0-4
21778808-7	2011	Collectively, we demonstrated that eEF2, a key factor involved in protein translational elongation is symmetrically arginine-methylated in a reversible manner, being regulated by bFGF through MAPK signaling pathway.	Arginine	116-124	mitogen-activated protein kinase 1	Mus musculus	192-196
22041521-9	2011	A functionally relevant p53 missense mutation in codon 273 of exon 8 [CGT (Arg) -&gt; CAT (His)] was confirmed by direct sequencing.	Arginine	75-78	tumor protein p53	Homo sapiens	24-27
22168140-7	2011	RESULTS: Pigs differ from NHPs and humans by a much lower C-peptide level (0.42 vs. 1.3 to 2.0 ng/ml, respectively) and a 2- to 7-fold lower C-peptide response to arginine stimulation.	Arginine	163-171	insulin	Homo sapiens	141-150
22168140-8	2011	In contrast, NHPs have the highest metabolic demand as evidenced by a high C-peptide and high C-peptide response to arginine stimulation; values are about twice higher than in humans.	Arginine	116-124	insulin	Homo sapiens	94-103
21550413-2	2011	NO is produced when L-arginine is converted to L-citrulline by NO synthase (NOS); however, L-arginine is also the substrate for arginase and both enzymes are upregulated in asthma.	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	63-74
22057999-9	2011	Meta-analysis results  showed that the Pro allele and Pro carrier (Arg/Pro + Pro/Pro) of p53 codon 72  polymorphism were significantly related with endometrial cancer risk (OR =  1.25, 95%CI = 1.10-1.41, P = 0.0005; OR = 1.34, 95%CI = 1.12-1.59, P = 0.001,  respectively).	Arginine	67-70	tumor protein p53	Homo sapiens	89-92
22057999-11	2011	We  concluded that the Pro allele (Arg/Pro + Pro/Pro) of p53 codon 72 polymorphism  is a potential risk factor for endometrial cancer.	Arginine	35-38	tumor protein p53	Homo sapiens	57-60
21987804-0	2011	Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.	Arginine	133-141	stromal interaction molecule 1	Homo sapiens	49-54
21948080-3	2011	Fine mapping of this locus with interval-specific congenic lines and association experiments using single nucleotide polymorphisms (SNPs) identified a nonsynonymous SNP in the Vav1 gene that leads to the substitution of an arginine by a tryptophan (p.Arg63Trp).	Arginine	223-231	vav guanine nucleotide exchange factor 1	Rattus norvegicus	176-180
22125489-4	2011	We focus on positions P-2 and P-5, commonly occupied by Arginine (Arg) in substrates of basophilic Ser/Thr kinases.	Arginine	56-64	solute carrier family 10 member 5	Homo sapiens	22-33
22125489-4	2011	We focus on positions P-2 and P-5, commonly occupied by Arginine (Arg) in substrates of basophilic Ser/Thr kinases.	Arginine	56-59	solute carrier family 10 member 5	Homo sapiens	22-33
22125489-9	2011	The acidic residue at position 230 serves as a pivotal element in recognizing Arg from both the P-2 and P-5 positions.	Arginine	78-81	solute carrier family 10 member 5	Homo sapiens	96-107
22180090-4	2011	Grb14 competes with cGMP for the CNGA1 binding pocket and electrostatically interacts with Arg(559) through a negatively charged beta-turn at its RA domain.	Arginine	91-94	growth factor receptor bound protein 14	Homo sapiens	0-5
21756062-1	2011	PURPOSE: Nitric oxide (NO), a reactive radical, is formed in higher amounts from L-arginine by inducible NO synthase (iNOS) during early response to ionizing radiation presumably as a part of signal transduction pathways.	Arginine	81-91	nitric oxide synthase 2	Rattus norvegicus	95-116
21878618-3	2011	Conserved amino acids Asp-102 and Arg-106 of FAHD1 were found important for its catalytic activity, and Mg(2+) was required for maximal enzyme activity.	Arginine	34-37	fumarylacetoacetate hydrolase domain containing 1	Homo sapiens	45-50
21849499-7	2011	The cleavage site in SelK was identified between Arg(81) and Gly(82) and the resulting truncated SelK was shown to lack selenocysteine, the amino acid that defines selenoproteins.	Arginine	49-52	selenoprotein K	Mus musculus	21-25
21849499-7	2011	The cleavage site in SelK was identified between Arg(81) and Gly(82) and the resulting truncated SelK was shown to lack selenocysteine, the amino acid that defines selenoproteins.	Arginine	49-52	selenoprotein K	Mus musculus	97-101
21793865-0	2011	Effect of exogenous l-arginine and ageing on NO and ET-1 in penile tissue of rat.	Arginine	20-30	endothelin 1	Rattus norvegicus	52-56
21740530-2	2011	Delivery of the nitric oxide synthase (NOS) substrate l-arginine, pharmacological nitric oxide (NO) donors, NO gas or overexpression of NOS proteins can inhibit SMC proliferation and reduce the injury responses within the blood vessel wall.	Arginine	54-64	nitric oxide synthase 2	Homo sapiens	16-37
21063737-0	2011	A role for PPARalpha in the regulation of arginine metabolism and nitric oxide synthesis.	Arginine	42-50	peroxisome proliferator activated receptor alpha	Mus musculus	11-20
21063737-9	2011	PPARalpha deficiency also increased plasma arginine and decreased citrulline concentration in plasma.	Arginine	43-51	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Arginine	12-20	SH3 domain containing kinase binding protein 1	Homo sapiens	62-67
21806669-4	2011	It is generated from the amino acid L-arginine via NO synthase (NOS).	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	51-62
21756062-1	2011	PURPOSE: Nitric oxide (NO), a reactive radical, is formed in higher amounts from L-arginine by inducible NO synthase (iNOS) during early response to ionizing radiation presumably as a part of signal transduction pathways.	Arginine	81-91	nitric oxide synthase 2	Rattus norvegicus	118-122
21807618-2	2011	Since tetrahydrobiopterin (BH(4)) is an essential cofactor for endothelial nitric oxide synthase (NOS3), decreased bioavailability of the substrate l-arginine and/or BH(4) may contribute to decreased NO production with hypercholesterolaemia.	Arginine	148-158	nitric oxide synthase 3	Homo sapiens	63-96
22331725-11	2011	The distribution of codon 72 TP53 genotypes was: Arg/Arg 38.5%, Arg/Pro 50.0%, Pro/Pro 11.5%.	Arginine	49-52	tumor protein p53	Homo sapiens	29-33
22417578-1	2011	A bioactive peptide Arg-Val-Pro-Ser-Leu (RVPSL) obtained from egg white protein was characterized by LC-MS and further chemically synthesized by the Fmoc solid phase method and investigated in terms of its angiotensin converting enzyme (ACE)-inhibitory activity, antioxidant property, and anticoagulation activity, as well as its stability in a simulated gastrointestinal digestion.	Arginine	20-23	angiotensin I converting enzyme	Homo sapiens	206-235
22417578-1	2011	A bioactive peptide Arg-Val-Pro-Ser-Leu (RVPSL) obtained from egg white protein was characterized by LC-MS and further chemically synthesized by the Fmoc solid phase method and investigated in terms of its angiotensin converting enzyme (ACE)-inhibitory activity, antioxidant property, and anticoagulation activity, as well as its stability in a simulated gastrointestinal digestion.	Arginine	20-23	angiotensin I converting enzyme	Homo sapiens	237-240
21784777-7	2011	DNA sequencing revealed a homozygous C T mutation at nucleotide-6392 in exon 10 of the C1R gene, resulting in a nonsense mutation from Arg-380 (R380X).	Arginine	135-138	complement C1r	Homo sapiens	87-90
21647154-4	2011	By contrast, mutations in IDH2 did not affect the homologous residue but instead altered codon 140, resulting in replacement of arginine with either glutamine (N=4) or tryptophan (N=1).	Arginine	128-136	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	26-30
21719463-0	2011	Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs.	Arginine	159-167	coagulation factor II, thrombin	Homo sapiens	114-129
21865597-8	2011	Mutation of Arg-90 of SGK3 disrupted the endosomal localization of SGK3 and delayed NHE3 activation.	Arginine	12-15	serum/glucocorticoid regulated kinase 3	Mus musculus	22-26
21865597-8	2011	Mutation of Arg-90 of SGK3 disrupted the endosomal localization of SGK3 and delayed NHE3 activation.	Arginine	12-15	serum/glucocorticoid regulated kinase 3	Mus musculus	67-71
21865597-8	2011	Mutation of Arg-90 of SGK3 disrupted the endosomal localization of SGK3 and delayed NHE3 activation.	Arginine	12-15	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	84-88
20641531-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	143-153
22038003-6	2011	Expression patterns of adipogenic transcription factors showed that exogenous myostatin suppressed PPARgamma2 and aP2 expression (P&lt;0.01), while supplemental arginine or myostatin antibody promoted ADD1 expression (P&lt;0.01).	Arginine	161-169	adducin 1	Homo sapiens	201-205
22038003-7	2011	Furthermore, compared with the addition of either myostatin protein or antibody alone, ADD1 and PPARdelta expression were promoted by the combination of arginine and myostatin (P&lt;0.01), and arginine combined with myostatin antibody promoted the expression of ADD1, PPARdelta, C/EBPalpha, PPARgamma2 and LPL in pMDSCs (P&lt;0.05).	Arginine	153-161	adducin 1	Homo sapiens	87-91
22038003-8	2011	These results suggest that myostatin inhibits adipogenesis in pMDSCs, and that this can be alleviated by arginine supplementation, at least in part, through promoting ADD1 and PPARdelta expression.	Arginine	105-113	adducin 1	Homo sapiens	167-171
21893043-3	2011	Substitution of alanine for Arg(93) or Arg(175) induced a 7-8-fold decrease in inhibition potency, while Arg(165)Ala, Lys(169)Ala, Arg(173)Ala and Arg(233)Ala thrombin mutants displayed a 2-4-fold decrease.	Arginine	28-31	coagulation factor II, thrombin	Homo sapiens	159-167
21893043-6	2011	Comparison of thrombin, factor Xa, factor IXa and factor VIIa primary sequences reiterated Arg(93) and Arg(175) as residues likely to be targeted by sulfated LMWLs.	Arginine	91-94	coagulation factor II, thrombin	Homo sapiens	14-56
21834532-1	2011	Mammalian nitric oxide synthase (NOS) is a flavo-hemoprotein that catalyzes the oxidation of L-arginine to nitric oxide.	Arginine	93-103	nitric oxide synthase 2	Homo sapiens	10-31
21517890-0	2011	HNA-3a-specific antibodies recognize choline transporter-like protein-2 peptides containing arginine, but not glutamine at Position 154.	Arginine	92-100	solute carrier family 44 member 2	Homo sapiens	37-71
21808068-7	2011	Catalysis required Arg-803 of RUTBC1, and RUTBC1 could activate a catalytically inhibited Rab33B mutant (Q92A), in support of a dual finger mechanism for RUTBC1 action.	Arginine	19-22	small G protein signaling modulator 2	Homo sapiens	30-36
21749319-8	2011	This identified Thr654 in EGFR as the PKN1 phosphorylation site and this retains an arginine residue at the -3 position.	Arginine	84-92	epidermal growth factor receptor	Homo sapiens	26-30
21884984-3	2011	We show that the neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4) negatively regulates REST (NRSF), a transcriptional repressor of genes required for neurogenesis.	Arginine	37-40	serine/arginine repetitive matrix 4	Mus musculus	76-82
21871446-0	2011	Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.	Arginine	27-37	insulin	Homo sapiens	0-7
21871446-0	2011	Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.	Arginine	27-37	AKT serine/threonine kinase 1	Homo sapiens	86-89
21871446-4	2011	In the current study we investigated the role of supply of the eNOS substrate, L-arginine as a candidate parallel mechanism underlying insulin-stimulated NO synthesis in cultured human aortic endothelial cells.	Arginine	79-89	insulin	Homo sapiens	135-142
21871446-5	2011	Insulin rapidly stimulated L-arginine transport, an effect abrogated by incubation with inhibitors of phosphatidylinositol-3"-kinase or infection with adenoviruses expressing a dominant negative mutant Akt.	Arginine	27-37	insulin	Homo sapiens	0-7
21871446-5	2011	Insulin rapidly stimulated L-arginine transport, an effect abrogated by incubation with inhibitors of phosphatidylinositol-3"-kinase or infection with adenoviruses expressing a dominant negative mutant Akt.	Arginine	27-37	AKT serine/threonine kinase 1	Homo sapiens	202-205
21871446-6	2011	Furthermore, supplementation of endothelial cells with extracellular L-arginine enhanced insulin-stimulated NO synthesis, an effect reversed by co-incubation with the L-arginine transport inhibitor, L-lysine.	Arginine	69-79	insulin	Homo sapiens	89-96
21871446-7	2011	Basal L-arginine transport was significantly increased under high glucose culture conditions, yet insulin-stimulated L-arginine transport remained unaltered.	Arginine	117-127	insulin	Homo sapiens	98-105
21871446-9	2011	We propose that rapid stimulation of L-arginine transport contributes to insulin-stimulated NO synthesis in human endothelial cells, yet attenuation of this is unlikely to underlie the inhibition of insulin-stimulated NO synthesis under high glucose conditions.	Arginine	37-47	insulin	Homo sapiens	73-80
21892948-10	2011	The mutation results in substitution of arginine for the highly conserved glycine at residue 199 located at the p53 dimer-dimer interface.	Arginine	40-48	tumor protein p53	Homo sapiens	112-115
21868366-3	2011	The arginine- and glycine-rich region of FMRP (the RGG box) is unique; it is the high-affinity RNA-binding motif in FMRP and is encoded by exon 15.	Arginine	4-12	fragile X messenger ribonucleoprotein 1	Homo sapiens	41-45
21868366-3	2011	The arginine- and glycine-rich region of FMRP (the RGG box) is unique; it is the high-affinity RNA-binding motif in FMRP and is encoded by exon 15.	Arginine	4-12	fragile X messenger ribonucleoprotein 1	Homo sapiens	116-120
21884984-3	2011	We show that the neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4) negatively regulates REST (NRSF), a transcriptional repressor of genes required for neurogenesis.	Arginine	37-40	serine/arginine repetitive matrix 4	Mus musculus	83-88
21685242-3	2011	Arginase and NO synthase (NOS) utilize the same substrate (l-arginine) and contribute to the fibrotic and inflammatory features of asthma, respectively.	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	13-24
21600318-8	2011	The induction of intrinsic disorder by arginine residues may be of primary importance in metabolism and function of exchangeable apolipoproteins, while their stability in nascent discoidal HDL is controlled by the physical state of phosphatidylcholine.	Arginine	39-47	apolipoprotein E	Homo sapiens	129-144
21600870-7	2011	Mutations of Asn227 Ala, Asp, Arg; Ile233 Ala; Leu243 Ala; Glu247 Asp; Glu248 Gln yielded significant reduction in NHE1 activity.	Arginine	30-33	solute carrier family 9 member A1	Homo sapiens	115-119
21235458-2	2011	It is produced in intact endothelial cells by endothelial NO synthase (eNOS) as the key enzyme from L-arginine.	Arginine	100-110	nitric oxide synthase 3	Homo sapiens	71-75
21723917-6	2011	OS-9 and the MPRs use the same four residues (Gln, Arg, Glu, and Tyr) to bind mannose.	Arginine	51-54	OS9 endoplasmic reticulum lectin	Homo sapiens	0-4
21177981-2	2011	Inflammation is accompanied by an increased maturation of DCs and the generation of kinins, particularly Lys-des[Arg(9)]-bradykinin (Lda-BK).	Arginine	113-116	kininogen 1	Homo sapiens	121-131
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Arginine	47-50	tumor protein p53	Homo sapiens	19-22
21816516-4	2011	It was found that the active compounds 3l, 3m and 3n intact mainly with Arg 44 amino acid, which may be involved in COX-2 inhibition.	Arginine	72-75	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
20695761-7	2011	Arginine/ADMA ratio also correlated inversely with fasting insulin (r =  -0.339, p = 0.050).	Arginine	0-8	insulin	Homo sapiens	59-66
21775527-3	2011	Therefore, we hypothesized that l-arginine, a substrate for iNOS, is acted upon by arginase-I (Arg-I), contributing to the resolution of inflammation.	Arginine	32-42	nitric oxide synthase 2, inducible	Mus musculus	60-64
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
21316118-4	2011	The frequencies of p53 codon 72 polymorphisms (Arg/Arg, Arg/Pro, and Pro/Pro) in LC were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p&lt;0.01).	Arginine	51-54	tumor protein p53	Homo sapiens	19-22
21873235-3	2011	Here we report that Malt1 cleaved the NF-kappaB family member RelB after Arg-85.	Arginine	73-76	RELB proto-oncogene, NF-kB subunit	Homo sapiens	62-66
21311355-7	2011	RESULTS: l-Arg increased the glucose rate of disappearance and glucose clearance rate during exercise; however, this was accompanied by a 150% increase in plasma insulin concentration from 65 to 75 min (P &lt; 0.05) that remained significantly elevated until 90 min of exercise.	Arginine	9-14	insulin	Homo sapiens	162-169
21311355-9	2011	CONCLUSIONS: The increase in glucose disposal after l-Arg infusion during exercise is likely due to the significantly higher plasma insulin concentration.	Arginine	52-57	insulin	Homo sapiens	132-139
21543238-1	2011	PURPOSE: The purpose of the study was to determine the frequency of occurrence of polymorphisms of genes MTHFR (C677T), MTR (A2756G), and MTHFD1 (G1958A), as well as to analyze the concentration of homocysteine (Hcy), methionine (Met), asymmetric dimethylarginine (ADMA), and arginine (Arg) in epileptics treatment with antiepileptic drugs (AEDs), and controls.	Arginine	255-263	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	138-144
21543238-1	2011	PURPOSE: The purpose of the study was to determine the frequency of occurrence of polymorphisms of genes MTHFR (C677T), MTR (A2756G), and MTHFD1 (G1958A), as well as to analyze the concentration of homocysteine (Hcy), methionine (Met), asymmetric dimethylarginine (ADMA), and arginine (Arg) in epileptics treatment with antiepileptic drugs (AEDs), and controls.	Arginine	286-289	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	138-144
21708156-2	2011	ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin).	Arginine	140-148	solute carrier family 30 member 8	Homo sapiens	0-4
21635951-7	2011	Further, NO is synthesized from l-arginine via the action of NO synthase (NOS), while NOS is blocked by endogenous l-arginine analogues such as asymmetric dimethylarginine (ADMA), a naturally occurring amino acid which is found in the plasma and various tissues.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	61-72
21635951-7	2011	Further, NO is synthesized from l-arginine via the action of NO synthase (NOS), while NOS is blocked by endogenous l-arginine analogues such as asymmetric dimethylarginine (ADMA), a naturally occurring amino acid which is found in the plasma and various tissues.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	61-72
21909878-3	2011	L-arginine (2 mM), a substrate for nitric oxide synthases (NOS), decreased COX-2 and PGE(2) levels, while N( G )-nitro-L-arginine methyl ester (L-NAME) (2 mM), a NOS inhibitor, had no influence on COX-2 and PGE(2) levels but limited tumor cell motility.	Arginine	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
21710975-5	2011	Molecular modeling and molecular dynamics simulations of AtNIP7;1 suggest that a conserved tyrosine residue (Tyr81) located in transmembrane helix 2 adjacent to the aromatic arginine (ar/R) pore selectivity region stabilizes a closed pore conformation through interaction with the canonical Arg220 in ar/R region.	Arginine	174-182	NOD26-like intrinsic protein 7;1	Arabidopsis thaliana	57-65
21490695-1	2011	BACKGROUND: Nitric oxide synthase (NOS) inhibitor asymmetrical dimethylarginine (ADMA) is synthesized by the methylation of arginine as part of the methionine/homocysteine cycle.	Arginine	71-79	nitric oxide synthase 2	Homo sapiens	12-33
21909878-3	2011	L-arginine (2 mM), a substrate for nitric oxide synthases (NOS), decreased COX-2 and PGE(2) levels, while N( G )-nitro-L-arginine methyl ester (L-NAME) (2 mM), a NOS inhibitor, had no influence on COX-2 and PGE(2) levels but limited tumor cell motility.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	35-57
21909878-3	2011	L-arginine (2 mM), a substrate for nitric oxide synthases (NOS), decreased COX-2 and PGE(2) levels, while N( G )-nitro-L-arginine methyl ester (L-NAME) (2 mM), a NOS inhibitor, had no influence on COX-2 and PGE(2) levels but limited tumor cell motility.	Arginine	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	197-202
21909878-6	2011	Summing up, we showed that addition of L-arginine at doses which did not stimulate NO level caused a significant decrease in COX-2 and PGE(2) amounts in co-cultures of colon tumor spheroids with normal epithelial cells and myofibroblasts.	Arginine	39-49	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-130
21843334-1	2011	BACKGROUND: Single-nucleotide polymorphisms within TP53 gene (codon 72 exon 4, rs1042522, encoding either arginine or proline) and MDM2 promoter (SNP309; rs2279744), have been independently associated with increased risk of several cancer types.	Arginine	106-114	tumor protein p53	Homo sapiens	51-55
21864793-1	2011	In this study, molecular dynamics simulations were carried out on Lys- and Arg-containing Ala-based peptides (i.e. Ace-(AAAAK)(n)A-NH(2) and Ace-(AAAAR)(n)A-NH(2), where n=1-4), in order to explore and characterize their folding processes.	Arginine	75-78	angiotensin I converting enzyme	Homo sapiens	115-118
21763278-16	2011	In HEK 293 cells, furin cleaved pro-BNP at Arg-76 whereas in cardiomyocytes corin cleaved pro-BNP at multiple residues including Arg-73, Arg-76 and Lys-79.	Arginine	129-132	corin, serine peptidase	Homo sapiens	76-81
21763278-16	2011	In HEK 293 cells, furin cleaved pro-BNP at Arg-76 whereas in cardiomyocytes corin cleaved pro-BNP at multiple residues including Arg-73, Arg-76 and Lys-79.	Arginine	129-132	corin, serine peptidase	Homo sapiens	76-81
21617140-6	2011	However, Arg I could attenuate the function of inducible nitric oxide synthase and inhibit the subsequent nuclear factor-kappaB activation, leading to inhibition of tumor necrosis factor-alpha generation.	Arginine	9-12	tumor necrosis factor	Homo sapiens	165-192
21529934-1	2011	Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein.	Arginine	157-160	fibrinogen beta chain	Homo sapiens	55-65
21586674-0	2011	Arginine transport in human monocytic leukemia THP-1 cells during macrophage differentiation.	Arginine	0-8	GLI family zinc finger 2	Homo sapiens	47-52
21547496-12	2011	RESULTS: Fifty-two week vildagliptin 100 mg (n = 26) treatment increased the primary efficacy variable, combined hyperglycaemia and arginine-stimulated C-peptide secretion (AIR(arg)), by 5.0 +- 1.8 nmol/l x min, while it decreased by 0.8 +- 1.8 nmol/l x min with placebo (n = 25) (between-group difference p = 0.030).	Arginine	132-140	insulin	Homo sapiens	152-161
21547496-12	2011	RESULTS: Fifty-two week vildagliptin 100 mg (n = 26) treatment increased the primary efficacy variable, combined hyperglycaemia and arginine-stimulated C-peptide secretion (AIR(arg)), by 5.0 +- 1.8 nmol/l x min, while it decreased by 0.8 +- 1.8 nmol/l x min with placebo (n = 25) (between-group difference p = 0.030).	Arginine	132-135	insulin	Homo sapiens	152-161
21461655-5	2011	RESULTS: The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively.	Arginine	28-31	tumor protein p53	Homo sapiens	75-78
21461655-5	2011	RESULTS: The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively.	Arginine	32-35	tumor protein p53	Homo sapiens	75-78
21461655-5	2011	RESULTS: The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively.	Arginine	32-35	tumor protein p53	Homo sapiens	75-78
21718007-2	2011	The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the l-arginine-bound ferric iNOS heme (Sempombe, J.; et al.	Arginine	92-102	nitric oxide synthase 2	Homo sapiens	116-120
21507611-5	2011	This mutation causes one highly conserved glycine residue transit to arginine on the 10th transmembrane region of PTCH protein.	Arginine	69-77	patched 1	Homo sapiens	114-118
21737361-1	2011	Nitric oxide (NO), the endogenous modulator of vascular tone and structure, originates from oxidation of L-arginine catalysed by NO synthase (NOS).	Arginine	105-115	nitric oxide synthase 2	Homo sapiens	129-140
21586674-3	2011	We show here that the induction of THP-1 monocyte differentiation by PMA markedly increases the expression of SLC7A7 mRNA and of y(+)LAT1 protein and consequently, the activity of system y(+)L-mediated arginine transport.	Arginine	202-210	GLI family zinc finger 2	Homo sapiens	35-40
21972595-0	2011	[L-arginine enhances Th1 immune response against Plasmodium yoelii 17XL infection in DBA/2 mice via activation of dendritic cells].	Arginine	1-11	negative elongation factor complex member C/D, Th1l	Mus musculus	21-24
21633971-6	2011	Furthermore, the basic Lys and Arg are enriched within SNARE N-terminal flanking regions.	Arginine	31-34	small NF90 (ILF3) associated RNA E	Homo sapiens	55-60
21679093-5	2011	A highly positively charged substrate, Ac-Val-Arg-Leu-Lys-His-Arg-Lys-Leu-Arg-pNA, containing the peptide surrounding the phosphorylated histidine in ion channel KCa3.1 was chemically phosphorylated using phosphoramidate.	Arginine	46-49	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	162-168
21972595-9	2011	CONCLUSION: L-Arg enhances Th1 immune responses during the early stage of P.y17XL infection in DBA/2 mice via the activation of DCs.	Arginine	12-17	negative elongation factor complex member C/D, Th1l	Mus musculus	27-30
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	36-44	epidermal growth factor receptor	Homo sapiens	170-174
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	46-49	epidermal growth factor receptor	Homo sapiens	170-174
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	51-54	epidermal growth factor receptor	Homo sapiens	170-174
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	51-54	epidermal growth factor receptor	Homo sapiens	170-174
20870896-10	2011	Finally, we found that supplementation with l-arginine restored Hsp90-GCH1 interactions and increased both BH(4) and NO(x) concentrations in Shunt lambs.	Arginine	44-54	GCH1	Ovis aries	70-74
21684157-1	2011	Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals.	Arginine	10-18	nitric oxide synthase 2	Homo sapiens	85-89
21478495-10	2011	It remains unclear whether the increased release of glutamate during the microdialysis evokes activation of inducible nitric oxide synthase (iNOS), which would utilize arginine in the formation of nitric oxide.	Arginine	168-176	nitric oxide synthase 2	Rattus norvegicus	108-139
21478495-10	2011	It remains unclear whether the increased release of glutamate during the microdialysis evokes activation of inducible nitric oxide synthase (iNOS), which would utilize arginine in the formation of nitric oxide.	Arginine	168-176	nitric oxide synthase 2	Rattus norvegicus	141-145
21439134-2	2011	NO is synthesized from l-arginine by NO synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	37-48
21638297-3	2011	L-arginine or L-citrulline administration reversed the increase in serum AST and ALT activities, urea and all lipid profiles.	Arginine	0-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	73-76
21120524-6	2011	Plasma arginine concentration was lower (p &lt; 0.05) in PH patients (23 +- 11 muM) versus non-PH patients (46 +- 24 muM).	Arginine	7-15	latexin	Homo sapiens	79-82
21617182-9	2011	Mass spectrometry peptide mapping identified arginine-18 as the hotspot site of apoB100 modification in MG(min)-LDL.	Arginine	45-53	apolipoprotein B	Homo sapiens	80-87
21120524-6	2011	Plasma arginine concentration was lower (p &lt; 0.05) in PH patients (23 +- 11 muM) versus non-PH patients (46 +- 24 muM).	Arginine	7-15	latexin	Homo sapiens	117-120
21402718-3	2011	By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele.	Arginine	124-132	tumor protein p53	Homo sapiens	15-18
21402718-4	2011	In humans, the diversity of haplotypes of the p53 gene has decreased during evolution, because the arginine allele, existing in only a subset of haplotypes, is under positive selection.	Arginine	99-107	tumor protein p53	Homo sapiens	46-49
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	23-26	ribosomal protein S2	Homo sapiens	48-52
21306304-4	2011	The arginine/ADMA ratio decreased significantly across increasing tertiles of CRP and MPO.	Arginine	4-12	C-reactive protein	Homo sapiens	78-81
21306304-4	2011	The arginine/ADMA ratio decreased significantly across increasing tertiles of CRP and MPO.	Arginine	4-12	myeloperoxidase	Homo sapiens	86-89
21306304-8	2011	Conversely, in a fully adjusted model, CRP was negatively associated with arginine [-2.8 (95% CI, -4.0 to -1.6) mumol/l arginine per S.D.	Arginine	74-82	C-reactive protein	Homo sapiens	39-42
21306304-8	2011	Conversely, in a fully adjusted model, CRP was negatively associated with arginine [-2.8 (95% CI, -4.0 to -1.6) mumol/l arginine per S.D.	Arginine	120-128	C-reactive protein	Homo sapiens	39-42
21306304-12	2011	In contrast, the relationship between CRP and arginine was not modified by levels of oxLDL.	Arginine	46-54	C-reactive protein	Homo sapiens	38-41
21447645-8	2011	administration of LCB or Sephadex beads induced within 24 h a CRTH2-dependent peritoneal eosinophilia, as well as CRTH2-independent activation of peritoneal Mphi that expressed Arg I, an M2 phenotype.	Arginine	177-180	clathrin, light polypeptide (Lcb)	Mus musculus	18-21
21447645-9	2011	LCB-induced Mphi exhibited elevated Arg I and a surface MR, reduced surface TLR2 levels, and no change in the levels of CHI3L1 or IL-10 production.	Arginine	36-39	clathrin, light polypeptide (Lcb)	Mus musculus	0-3
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	23-26	protein arginine methyltransferase 3	Homo sapiens	111-147
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	23-26	protein arginine methyltransferase 3	Homo sapiens	149-154
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	92-95	ribosomal protein S2	Homo sapiens	48-52
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	92-95	protein arginine methyltransferase 3	Homo sapiens	111-147
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	92-95	protein arginine methyltransferase 3	Homo sapiens	149-154
22470009-7	2011	hydrolyzed whey protein), which has a high content of branched-chain amino acids such as leucine, valine and others such as arginine, which leads to improvements in insulin secretion and uptake glucose, since it increases insulin sensitivity.	Arginine	124-132	insulin	Homo sapiens	165-172
21463677-4	2011	EIF2AK4 (GCN2) is activated by depletion of l-arginine, which is used by nitric oxide synthase (NOS) during the production of NO( ).	Arginine	44-54	nitric oxide synthase 2	Homo sapiens	73-94
21518769-3	2011	Substitution of leucines for three arginines on the polar surface indicated that the same helix also mediated the association of GADD34 with mitochondria.	Arginine	35-44	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	129-135
21712817-1	2011	Nitric oxide (NO) is an unstable signalling molecule synthesized de novo mainly from L-arginine by NO synthase (NOS) enzymes.	Arginine	85-95	nitric oxide synthase 2	Homo sapiens	99-110
21565201-13	2011	iNOS and NT levels were higher in the l-Arg group and lower in the Allo group.	Arginine	38-43	nitric oxide synthase 2	Rattus norvegicus	0-4
21646374-3	2011	We show here that S6 kinase, activated in the liver upon feeding, can phosphorylate PGC-1alpha directly on two sites within its arginine/serine-rich (RS) domain.	Arginine	128-136	PPARG coactivator 1 alpha	Homo sapiens	84-94
21642970-1	2011	We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA.	Arginine	68-76	fragile X messenger ribonucleoprotein 1	Homo sapiens	117-153
21642970-1	2011	We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA.	Arginine	68-76	fragile X messenger ribonucleoprotein 1	Homo sapiens	155-159
22214528-2	2011	The aim of this study was to detect the effect of increased expression of RAGE on the angiogenic response to limb ischemia in diabetes by targeting alphavbeta3 integrin with 99mTc-labeled Arg-Gly-Asp (RGD).	Arginine	188-191	advanced glycosylation end product-specific receptor	Mus musculus	74-78
21293034-4	2011	We have shown that arginine (Arg), leucine (Leu), and glucose stimulate protein synthesis through phosphorylation of MTOR signaling molecules, thereby increasing proliferation of ovine trophectoderm cells.	Arginine	19-27	mechanistic target of rapamycin kinase	Homo sapiens	117-121
21574873-2	2011	Intravenous (IV) administration of l-arginine invokes a large metabolic (nitrate/nitrite (NO(x))) and hormonal (growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin) response; however, research examining oral l-arginine supplementation is conflicting, potentially owing to dose.	Arginine	35-45	growth hormone 1	Homo sapiens	112-126
21574873-2	2011	Intravenous (IV) administration of l-arginine invokes a large metabolic (nitrate/nitrite (NO(x))) and hormonal (growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin) response; however, research examining oral l-arginine supplementation is conflicting, potentially owing to dose.	Arginine	35-45	growth hormone 1	Homo sapiens	128-130
21574873-2	2011	Intravenous (IV) administration of l-arginine invokes a large metabolic (nitrate/nitrite (NO(x))) and hormonal (growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin) response; however, research examining oral l-arginine supplementation is conflicting, potentially owing to dose.	Arginine	35-45	insulin like growth factor 1	Homo sapiens	133-161
21574873-2	2011	Intravenous (IV) administration of l-arginine invokes a large metabolic (nitrate/nitrite (NO(x))) and hormonal (growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin) response; however, research examining oral l-arginine supplementation is conflicting, potentially owing to dose.	Arginine	35-45	insulin like growth factor 1	Homo sapiens	163-168
21574873-2	2011	Intravenous (IV) administration of l-arginine invokes a large metabolic (nitrate/nitrite (NO(x))) and hormonal (growth hormone (GH), insulin-like growth factor 1 (IGF-1), and insulin) response; however, research examining oral l-arginine supplementation is conflicting, potentially owing to dose.	Arginine	35-45	insulin	Homo sapiens	133-140
21574873-3	2011	The purpose of this study was examine a low and high dose of oral l-arginine on blood l-arginine, NO(x), GH, IGF-1, and insulin response.	Arginine	66-76	growth hormone 1	Homo sapiens	105-107
21574873-3	2011	The purpose of this study was examine a low and high dose of oral l-arginine on blood l-arginine, NO(x), GH, IGF-1, and insulin response.	Arginine	66-76	insulin like growth factor 1	Homo sapiens	109-114
21574873-3	2011	The purpose of this study was examine a low and high dose of oral l-arginine on blood l-arginine, NO(x), GH, IGF-1, and insulin response.	Arginine	66-76	insulin	Homo sapiens	120-127
21574873-10	2011	Based on these findings, a low dose of l-arginine was just as effective at increasing plasma l-arginine concentrations as a high dose; however, neither dose was able to promote a significant increase in NO(x), GH, IGF-1, or insulin at rest.	Arginine	39-49	insulin	Homo sapiens	224-231
21293034-10	2011	Importantly, Arg, Leu, Gln, and glucose increased the abundance of phosphorylated MTOR, RPS6K, RPS6, and EIF4EBP1 proteins as well as NOS and ODC1 proteins, but only Arg increased the abundance of IFNT protein.	Arginine	13-16	mechanistic target of rapamycin kinase	Homo sapiens	82-86
21293034-11	2011	These findings indicate that Arg, Leu, Gln, and glucose stimulate translation of mRNAs to increase synthesis of proteins through phosphorylation and activation of components of the MTOR signaling pathway.	Arginine	29-32	mechanistic target of rapamycin kinase	Homo sapiens	181-185
21293034-12	2011	Increases in abundance of IFNT protein (the pregnancy recognition signal), NOS2, NOS3 and GCH1 for conversion of Arg to nitric oxide, and ODC1 for synthesis of polyamines are all important for growth and development of the ovine conceptus during pregnancy.	Arginine	113-116	nitric oxide synthase 2	Homo sapiens	75-79
21293034-12	2011	Increases in abundance of IFNT protein (the pregnancy recognition signal), NOS2, NOS3 and GCH1 for conversion of Arg to nitric oxide, and ODC1 for synthesis of polyamines are all important for growth and development of the ovine conceptus during pregnancy.	Arginine	113-116	nitric oxide synthase 3	Homo sapiens	81-85
21293034-4	2011	We have shown that arginine (Arg), leucine (Leu), and glucose stimulate protein synthesis through phosphorylation of MTOR signaling molecules, thereby increasing proliferation of ovine trophectoderm cells.	Arginine	29-32	mechanistic target of rapamycin kinase	Homo sapiens	117-121
20497197-2	2011	[(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation.	Arginine	19-22	prepronociceptin	Homo sapiens	36-41
20497197-2	2011	[(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation.	Arginine	19-22	prepronociceptin	Homo sapiens	64-67
21492974-5	2011	However, some metabolic steps of amino acids related to vascular complications (methionine and arginine) exhibit a defective response to insulin in T2DM subjects with nephropathy.	Arginine	95-103	insulin	Homo sapiens	137-144
20497197-2	2011	[(pF)Phe(4) Aib(7) Arg(14) Lys(15) ]N/OFQ-NH(2) (UFP-112) is an NOP receptor ligand designed using a combination of several chemical modifications in the same peptide sequence that increase NOP receptor affinity/potency and/or reduce susceptibility to enzymatic degradation.	Arginine	19-22	prepronociceptin	Homo sapiens	190-193
21067292-0	2011	Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction.	Arginine	10-20	BCL2 apoptosis regulator	Homo sapiens	42-47
21668335-2	2011	Substitution of glycine for asparagine and addition of two arginine residues raise the isoelectric point of insulin glargine and result in microprecipitates, delaying absorption from subcutaneous tissue.	Arginine	59-67	insulin	Homo sapiens	108-115
21193457-11	2011	rReg4 could protect against arginine-induced necrosis of acinar cells both in vivo and in vitro.	Arginine	28-36	regenerating family member 4	Rattus norvegicus	0-5
21193457-13	2011	It was shown that arginine induced expression of Bcl-2 and Bcl-xL, while rReg4 upregulated Bcl-2 and Bcl-xL expression by activating the EGFR/Akt pathway.	Arginine	18-26	B cell leukemia/lymphoma 2	Mus musculus	49-54
20559724-1	2011	BACKGROUND: Nitric oxide (NO), synthesized from LS: -arginine by the enzyme endothelial nitric oxide synthase (eNOS), is a potent vasodilator and has been implicated in mediating insulin-induced uptake and metabolism of glucose in skeletal muscle.	Arginine	53-61	nitric oxide synthase 3	Homo sapiens	76-109
20559724-1	2011	BACKGROUND: Nitric oxide (NO), synthesized from LS: -arginine by the enzyme endothelial nitric oxide synthase (eNOS), is a potent vasodilator and has been implicated in mediating insulin-induced uptake and metabolism of glucose in skeletal muscle.	Arginine	53-61	nitric oxide synthase 3	Homo sapiens	111-115
21067292-0	2011	Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction.	Arginine	10-20	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
21067292-1	2011	OBJECTIVE: To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta.	Arginine	40-50	BCL2 apoptosis regulator	Homo sapiens	115-120
21067292-1	2011	OBJECTIVE: To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta.	Arginine	40-50	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
21067292-10	2011	Compared with L-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group.	Arginine	14-24	BCL2 associated X, apoptosis regulator	Homo sapiens	36-39
21067292-10	2011	Compared with L-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group.	Arginine	14-24	BCL2 apoptosis regulator	Homo sapiens	66-71
21067292-11	2011	CONCLUSIONS: L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.	Arginine	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58
21067292-11	2011	CONCLUSIONS: L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.	Arginine	13-23	BCL2 apoptosis regulator	Homo sapiens	90-95
21631225-3	2011	Endothelial nitric oxide synthase genes encode eNOS, which synthesizes NO from l-arginine.	Arginine	79-89	nitric oxide synthase 3	Homo sapiens	0-33
21441599-8	2011	Replacement of Trp with Ala and Arg with dArg abolished the ability of PMX-53 to inhibit C5a-induced Ca(2+) mobilization in HMC-1 cells and to cause degranulation in RBL-2H3 cells expressing MrgX2.	Arginine	32-35	complement C5a receptor 1	Homo sapiens	89-92
21441599-11	2011	Furthermore, Trp and Arg residues are required for the ability of PMX53 to act as both a CD88 antagonist and a MrgX2 agonist.	Arginine	21-24	complement C5a receptor 1	Homo sapiens	89-93
21441599-11	2011	Furthermore, Trp and Arg residues are required for the ability of PMX53 to act as both a CD88 antagonist and a MrgX2 agonist.	Arginine	21-24	MAS related GPR family member X2	Homo sapiens	111-116
21631225-3	2011	Endothelial nitric oxide synthase genes encode eNOS, which synthesizes NO from l-arginine.	Arginine	79-89	nitric oxide synthase 3	Homo sapiens	47-51
21549779-8	2011	Taken together, these results suggest a novel way for local kinin and des-Arg-kinin generation in the nervous tissue during pathological states accompanied by interferon-gamma release.	Arginine	74-77	interferon gamma	Homo sapiens	159-175
21738492-1	2011	Transportin-SR (TRN-SR) is a member of the importin-beta super-family that functions as the nuclear import receptor for serine-arginine rich (SR) proteins, which play diverse roles in RNA metabolism.	Arginine	127-135	transportin 3	Homo sapiens	0-14
21738492-1	2011	Transportin-SR (TRN-SR) is a member of the importin-beta super-family that functions as the nuclear import receptor for serine-arginine rich (SR) proteins, which play diverse roles in RNA metabolism.	Arginine	127-135	transportin 3	Homo sapiens	16-22
21385867-2	2011	We present strong experimental evidence that two highly conserved arginine residues play a vital role in this activity of human Prx2 and Prx3.	Arginine	66-74	peroxiredoxin 2	Homo sapiens	128-132
21419856-5	2011	This increase was only partially prevented by the absence of l-arginine and by the presence of l-N-acetyl-methyl-arginine (L-NAME), strongly suggesting that this response was in part related to the activation of NO-synthase (NOS) enzyme.	Arginine	61-71	nitric oxide synthase 2	Homo sapiens	212-223
21419857-4	2011	NO is synthesized by nitric oxide synthase (NOS) using l-arginine as substrate.	Arginine	55-65	nitric oxide synthase 2	Homo sapiens	21-42
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	83-86	tumor necrosis factor	Homo sapiens	58-67
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	87-90	tumor necrosis factor	Homo sapiens	58-67
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	87-90	tumor necrosis factor	Homo sapiens	58-67
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	87-90	tumor necrosis factor	Homo sapiens	58-67
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	87-90	tumor necrosis factor	Homo sapiens	58-67
21914340-8	2011	The analysis showed that comparing with the non-carriers, TNF-alpha gene 238 locus Arg/Arg, Arg/Gln, Gln/Arg + Arg/Arg carriers were 6.03-fold (95%CI: 1.35 - 26.97), 1.87-fold (95%CI: 1.07 - 3.30) and 2.36-fold (95%CI: 1.37 - 4.07) more susceptible to pneumoconiosis.	Arginine	87-90	tumor necrosis factor	Homo sapiens	58-67
21914340-9	2011	CONCLUSION: TNF-alpha gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.	Arginine	46-49	tumor necrosis factor	Homo sapiens	12-21
21914340-9	2011	CONCLUSION: TNF-alpha gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.	Arginine	46-49	tumor necrosis factor	Homo sapiens	12-21
21914340-9	2011	CONCLUSION: TNF-alpha gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.	Arginine	46-49	tumor necrosis factor	Homo sapiens	12-21
21914340-9	2011	CONCLUSION: TNF-alpha gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.	Arginine	46-49	tumor necrosis factor	Homo sapiens	12-21
21914340-9	2011	CONCLUSION: TNF-alpha gene 308, 238 locus Arg/Arg, Gln/Arg, Gln/Arg + Arg/Arg carriers are more susceptible to pneumoconiosis.	Arginine	46-49	tumor necrosis factor	Homo sapiens	12-21
21626334-6	2011	This mutation causes a nonsense mutation (Arg-to-Stop codon) that has been shown to attenuate p53 function.	Arginine	42-45	tumor protein p53	Homo sapiens	94-97
21454715-7	2011	A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression.	Arginine	23-26	tumor protein p53	Homo sapiens	125-128
21454683-1	2011	The common polymorphism of p53 at codon 72, either encoding proline or arginine, has drawn attention as a genetic factor associated with clinical outcome or cancer risk for the last 2 decades.	Arginine	71-79	tumor protein p53	Homo sapiens	27-30
21454683-3	2011	The arginine form (p53-72R) shows significantly enhanced phosphorylation at Ser-6 and Ser-20 compared with the proline form (p53-72P).	Arginine	4-12	tumor protein p53	Homo sapiens	19-22
21454683-3	2011	The arginine form (p53-72R) shows significantly enhanced phosphorylation at Ser-6 and Ser-20 compared with the proline form (p53-72P).	Arginine	4-12	tumor protein p53	Homo sapiens	125-128
21454479-6	2011	In addition, loss of the histone chaperone Hif1p, when combined with an allele of H3 that mutates lysines 14 and 23 to arginine, has a pronounced effect on chromatin reassembly that is similar to that observed in an asf1Delta.	Arginine	119-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-48
21454715-7	2011	A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression.	Arginine	23-26	tumor protein p53	Homo sapiens	152-155
20949368-2	2011	Impaired NO formation in response to AC-conditioned medium (CM) was facilitated by arginase II (ARG II) expression, which competes with inducible NO synthase for L-arginine.	Arginine	162-172	nitric oxide synthase 2, inducible	Mus musculus	136-157
20931344-0	2011	Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: a novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates.	Arginine	113-121	N-acetylglutamate synthase	Sus scrofa	33-59
20931344-1	2011	The objective of this study was to determine developmental changes in mRNA and protein levels for N-acetylglutamate synthase (NAGS; a key enzyme in synthesis of citrulline and arginine from glutamine/glutamate and proline) in the small intestine of suckling piglets.	Arginine	176-184	N-acetylglutamate synthase	Sus scrofa	98-124
20931344-1	2011	The objective of this study was to determine developmental changes in mRNA and protein levels for N-acetylglutamate synthase (NAGS; a key enzyme in synthesis of citrulline and arginine from glutamine/glutamate and proline) in the small intestine of suckling piglets.	Arginine	176-184	N-acetylglutamate synthase	Sus scrofa	126-130
20931344-9	2011	The postnatal decrease in NAGS protein levels was consistent with the previous report of reduced NAGS enzymatic activity as well as reduced synthesis of citrulline and arginine in the small intestine of 7- to 28-day-old pigs.	Arginine	168-176	N-acetylglutamate synthase	Sus scrofa	26-30
21490317-6	2011	CONCLUSIONS: Gating pore currents arising from missense mutations at arginine residues in the voltage sensor domains of Na(V)1.4 are a common feature of HypoPP mutant channels and contribute to the attacks of paralysis.	Arginine	69-77	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	153-159
20713020-5	2011	The arginine of the conserved E/DRY motif, R3.50, is not involved in the communication paths but participates in the structure network as a stable hub, being linked to both D3.49 and E6.30 like in the inactive states of rhodopsin.	Arginine	4-12	rhodopsin	Homo sapiens	220-229
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	Arginine	122-125	cAMP responsive element binding protein 1	Mus musculus	0-4
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	Arginine	122-125	cAMP responsive element binding protein 1	Mus musculus	84-88
21406573-6	2011	Patients with high plasma concentrations of C-reactive protein and mice with acute inflammation induced by lipopolysaccharide had significant reductions of arginine metabolites in plasma compared with controls.	Arginine	156-164	C-reactive protein	Homo sapiens	44-62
21361855-5	2011	METHODS: GH concentration in 97 serum samples from children undergoing a growth hormone releasing hormone+arginine stimulation test was measured using Siemens IMMULITE electro-chemiluminescence method, calibrated with both IS 80/505 and IS 98/574 (GRH Growth hormone-Recombinant 98/574-kit).	Arginine	106-114	growth hormone 1	Homo sapiens	9-11
21307143-4	2011	METHODS: Peak GH after GHRH-Arg and IGF1.	Arginine	28-31	growth hormone releasing hormone	Homo sapiens	23-27
21454242-11	2011	The Arg52Gly mutation replaces the normal arginine residue (CGC) with a glycine residue (GGC) at position 52 of the resultant menin protein.	Arginine	42-50	menin 1	Homo sapiens	126-131
21454242-14	2011	Nonconservative replacement of arginine, a small, neutral amino acid, with glycine, a bulky positively charged amino acid, could potentially have a deleterious effect on the menin protein.	Arginine	31-39	menin 1	Homo sapiens	174-179
21307143-10	2011	CONCLUSIONS: Single peak GH cut-offs have limits to sharply differentiate GHD from normal subjects; IGF1 may be used for selecting patients to be submitted to the GHRH-Arg test; the peak GH cut-off limits to be used for identifying healthy or diseased patients depend mainly on the clinical context.	Arginine	168-171	insulin like growth factor 1	Homo sapiens	100-104
20884675-8	2011	The arginine test induced a normal GH peak in nine patients (53%; Arg+), whereas the response was absent in the remaining eight (47%; Arg-).	Arginine	4-12	growth hormone 1	Homo sapiens	35-37
21291320-10	2011	CONCLUSIONS: These data suggest that the p53 codon 72 Arg/Arg genotype and Arg allele are associated with a lower risk of bladder cancer in Chinese population.	Arginine	54-57	tumor protein p53	Homo sapiens	41-44
21291320-10	2011	CONCLUSIONS: These data suggest that the p53 codon 72 Arg/Arg genotype and Arg allele are associated with a lower risk of bladder cancer in Chinese population.	Arginine	58-61	tumor protein p53	Homo sapiens	41-44
21291320-10	2011	CONCLUSIONS: These data suggest that the p53 codon 72 Arg/Arg genotype and Arg allele are associated with a lower risk of bladder cancer in Chinese population.	Arginine	58-61	tumor protein p53	Homo sapiens	41-44
21697043-1	2011	Deimination, the conversion of protein-bound arginines into citrullines, is a post-translational modification catalyzed by a peptidylarginine deiminase (Pad).	Arginine	45-54	paddle	Mus musculus	125-151
21697043-1	2011	Deimination, the conversion of protein-bound arginines into citrullines, is a post-translational modification catalyzed by a peptidylarginine deiminase (Pad).	Arginine	45-54	paddle	Mus musculus	153-156
21623030-1	2011	Nitric oxide (NO), synthesized from the amino acid, L-arginine by nitric oxide synthase (NOS) has received attention as a neurotransmitter in the brain.	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	66-87
20884675-0	2011	Growth hormone response to arginine test differentiates between two subgroups of Huntington"s disease patients.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
20884675-3	2011	The aim of the study was to evaluate the growth hormone (GH) response to arginine infusion in a cohort of HD patients, to search for an in vivo biomarker of hypothalamic dysfunction.	Arginine	73-81	growth hormone 1	Homo sapiens	41-55
20884675-3	2011	The aim of the study was to evaluate the growth hormone (GH) response to arginine infusion in a cohort of HD patients, to search for an in vivo biomarker of hypothalamic dysfunction.	Arginine	73-81	growth hormone 1	Homo sapiens	57-59
20884675-9	2011	Arg+ and Arg- also showed two distinct endocrine/metabolic profiles with differences in insulin and lipid metabolism.	Arginine	0-3	insulin	Homo sapiens	88-95
20884675-9	2011	Arg+ and Arg- also showed two distinct endocrine/metabolic profiles with differences in insulin and lipid metabolism.	Arginine	9-12	insulin	Homo sapiens	88-95
20884675-10	2011	CONCLUSION: It remains to be clarified if these two subgroups of patients, according to the GH response to arginine, correspond to different disease stages or to different patterns of neurodegeneration.	Arginine	107-115	growth hormone 1	Homo sapiens	92-94
21441910-6	2011	Analogous to BRAF (refs 8, 9), KSR2 self-associates through a side-to-side interface involving Arg 718, a residue identified in a genetic screen as a suppressor of Ras signalling.	Arginine	95-98	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	13-17
20619625-8	2011	Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-alpha in adipose tissue.	Arginine	8-11	lipoprotein lipase	Sus scrofa	112-130
20619625-8	2011	Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-alpha in adipose tissue.	Arginine	8-11	solute carrier family 2 member 4	Sus scrofa	132-194
21439861-3	2011	Therefore, the aim of this study was to investigate the occurrence of G(s)alpha mutation at the Arg(201) codon in hBMSCs and human trabecular bone cells (hTBCs, osteoblast-like cells).	Arginine	96-99	GNAS complex locus	Homo sapiens	70-79
21439861-6	2011	We studied the G(s)alpha mutations at the Arg(201) codon by means of polymerase chain reaction (PCR)-restriction fragment length polymorphism.	Arginine	42-45	GNAS complex locus	Homo sapiens	15-24
21195184-0	2011	Refolding single-chain antibody (scFv) using lauroyl-L-glutamate as a solubilization detergent and arginine as a refolding additive.	Arginine	99-107	immunglobulin heavy chain variable region	Homo sapiens	33-37
21441910-6	2011	Analogous to BRAF (refs 8, 9), KSR2 self-associates through a side-to-side interface involving Arg 718, a residue identified in a genetic screen as a suppressor of Ras signalling.	Arginine	95-98	kinase suppressor of ras 2	Homo sapiens	31-35
21291901-7	2011	The PON1 activity toward paraoxonase was found to be significantly higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes in both workers and control subjects (p&lt;0.001).	Arginine	86-89	paraoxonase 1	Homo sapiens	4-8
21291901-7	2011	The PON1 activity toward paraoxonase was found to be significantly higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes in both workers and control subjects (p&lt;0.001).	Arginine	90-93	paraoxonase 1	Homo sapiens	4-8
21291901-7	2011	The PON1 activity toward paraoxonase was found to be significantly higher in the R/R (Arg/Arg) genotypes than Q/R (Gln/Arg) and lowest in Q/Q (Gln/Gln) genotypes in both workers and control subjects (p&lt;0.001).	Arginine	90-93	paraoxonase 1	Homo sapiens	4-8
21444773-0	2011	Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.	Arginine	0-8	BCL2 apoptosis regulator	Homo sapiens	24-29
21366335-3	2011	In alpha-amylases and ACE, removal of chloride from the binding site triggers formation of a salt bridge between the positively charged Arg or Lys residue involved in chloride binding and a nearby carboxylate residue.	Arginine	136-139	angiotensin I converting enzyme	Homo sapiens	22-25
20226548-1	2011	UNLABELLED: The synthetic arginine-derived direct thrombin inhibitor argatroban is an attractive anticoagulant for percutaneous coronary intervention (PCI), because of its rapid onset and offset, and its hepatic elimination.	Arginine	26-34	coagulation factor II, thrombin	Homo sapiens	50-58
21444773-0	2011	Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.	Arginine	0-8	AKT serine/threonine kinase 1	Homo sapiens	113-116
21444773-2	2011	We have previously reported that PRMT1 methylates Forkhead box O transcription factors at two arginine residues within an Akt consensus phosphorylation motif (RxRxxS/T), and that this methylation blocks Akt-mediated phosphorylation of the transcription factors.	Arginine	94-102	AKT serine/threonine kinase 1	Homo sapiens	122-125
21444773-2	2011	We have previously reported that PRMT1 methylates Forkhead box O transcription factors at two arginine residues within an Akt consensus phosphorylation motif (RxRxxS/T), and that this methylation blocks Akt-mediated phosphorylation of the transcription factors.	Arginine	94-102	AKT serine/threonine kinase 1	Homo sapiens	203-206
21444773-3	2011	These findings led us to hypothesize that the functional crosstalk between arginine methylation and phosphorylation could be extended to other Akt target proteins as well as Forkhead box O proteins.	Arginine	75-83	AKT serine/threonine kinase 1	Homo sapiens	143-146
21444773-6	2011	Consistent with the hypothesis, PRMT1-mediated methylation of these two arginine residues inhibits Akt-mediated phosphorylation of BAD at Ser-99 in vitro and in vivo.	Arginine	72-80	AKT serine/threonine kinase 1	Homo sapiens	99-102
21444773-10	2011	Taken together, our results add a new dimension to the complexity of posttranslational BAD regulation and provide evidence that arginine methylation within an Akt consensus phosphorylation motif functions as an inhibitory modification against Akt-dependent survival signaling.	Arginine	128-136	AKT serine/threonine kinase 1	Homo sapiens	159-162
21444773-10	2011	Taken together, our results add a new dimension to the complexity of posttranslational BAD regulation and provide evidence that arginine methylation within an Akt consensus phosphorylation motif functions as an inhibitory modification against Akt-dependent survival signaling.	Arginine	128-136	AKT serine/threonine kinase 1	Homo sapiens	243-246
21188584-12	2011	Peptides insert their two N -terminal arginines or their C-terminal tyrosines in the TLR-2 coil.	Arginine	38-47	toll like receptor 2	Homo sapiens	85-90
21396910-0	2011	A single replacement of histidine to arginine in EGFR-lytic hybrid peptide demonstrates the improved anticancer activity.	Arginine	37-45	epidermal growth factor receptor	Homo sapiens	49-53
21396910-3	2011	When cytotoxic activity of EGFR-lytic or EGFR(2R)-lytic hybrid peptides was investigated in various human cancer and normal cell lines, it was demonstrated that EGFR(2R)-lytic, in which second histidine (H) of EGFR-binding peptide was replaced to arginine (R) had 1.2-1.9-fold higher cytotoxic activity than that of original EGFR-lytic peptide.	Arginine	247-255	epidermal growth factor receptor	Homo sapiens	27-31
21396910-5	2011	These results suggest that mutated arginine on EGFR-lytic peptide produces higher binding ability to EGFR on cancer cells, and thereby the improved anticancer activity.	Arginine	35-43	epidermal growth factor receptor	Homo sapiens	47-51
21396910-5	2011	These results suggest that mutated arginine on EGFR-lytic peptide produces higher binding ability to EGFR on cancer cells, and thereby the improved anticancer activity.	Arginine	35-43	epidermal growth factor receptor	Homo sapiens	101-105
21355573-3	2011	Whereas BK exhibits a stronger interaction with the membrane and prefers to stay on the interface, des-Arg9-BK, with the loss of C-terminal Arg, penetrates further.	Arginine	103-106	kininogen 1	Homo sapiens	108-110
21428916-4	2011	In searching for a physiological process regulated by amino acids, we have demonstrated recently that arginine plays a role in the activation of LPS (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages.	Arginine	102-110	mitogen-activated protein kinase kinase 7	Homo sapiens	178-181
21428916-4	2011	In searching for a physiological process regulated by amino acids, we have demonstrated recently that arginine plays a role in the activation of LPS (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages.	Arginine	102-110	mitogen-activated protein kinase 1	Homo sapiens	183-187
21428916-4	2011	In searching for a physiological process regulated by amino acids, we have demonstrated recently that arginine plays a role in the activation of LPS (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages.	Arginine	102-110	mitogen-activated protein kinase 1	Homo sapiens	223-226
21428916-4	2011	In searching for a physiological process regulated by amino acids, we have demonstrated recently that arginine plays a role in the activation of LPS (lipopolysaccharide)-induced MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling in macrophages.	Arginine	102-110	mitogen-activated protein kinase 1	Homo sapiens	228-278
21428916-5	2011	PP2A similarly associates with the upstream regulator of MEK in this signalling pathway, TPL-2 (tumour progression locus-2), in response to arginine availability.	Arginine	140-148	mitogen-activated protein kinase kinase 7	Homo sapiens	57-60
21262961-3	2011	We inserted GFP into RyR2 after residues Arg-626 and Tyr-846 to generate GFP-RyR2 fusion proteins, RyR2Arg-626-GFP and RyR2Tyr-846-GFP.	Arginine	41-44	ryanodine receptor 2	Homo sapiens	21-25
21262961-4	2011	Insertion of GFP after residue Arg-626 abolished the binding of a bulky GST- or cyan fluorescent protein-tagged FKBP12.6 but not the binding of a smaller, nontagged FKBP12.6, suggesting that residue Arg-626 and the dantrolene-binding sequence are located near the FKBP12.6-binding site.	Arginine	31-34	FKBP prolyl isomerase 1B	Homo sapiens	112-120
21262961-7	2011	Based on the FRET efficiencies of these FRET pairs and the corresponding distance relationships, we mapped the three-dimensional location of Arg-626-GFP or -cyan fluorescent protein, hence the dantrolene-binding sequence, to domain 9 near the FKBP12.6-binding site but distant to the central region around residue Ser-2367.	Arginine	141-144	FKBP prolyl isomerase 1B	Homo sapiens	243-251
21220433-10	2011	Over the years, the test of first choice shifted from ITT toward GHRH-arginine test.	Arginine	70-78	growth hormone releasing hormone	Homo sapiens	65-69
21439247-7	2011	The results from this large-sample sized meta-analysis suggest that the p21 31Arg/Arg genotype may serve as a potential marker for increased cancer risk.	Arginine	78-81	cyclin dependent kinase inhibitor 1A	Homo sapiens	72-75
21330640-5	2011	RESULTS: Valsartan increased first-phase (P = 0.028) and second-phase (P = 0.002) glucose-stimulated insulin secretion compared with placebo, whereas the enhanced arginine-stimulated insulin secretion was comparable between groups (P = 0.25).	Arginine	163-171	insulin	Homo sapiens	183-190
21172428-1	2011	The homodimeric flavohemeprotein endothelial nitric oxide synthase (eNOS) oxidizes l-arginine to l-citrulline and nitric oxide (NO), which acutely vasodilates blood vessels and inhibits platelet aggregation.	Arginine	83-93	nitric oxide synthase 3	Homo sapiens	33-66
21338328-2	2011	It is formed from L-arginine by NOS isoforms (nNOS, iNOS and eNOS).	Arginine	18-28	nitric oxide synthase 2	Homo sapiens	52-56
21338328-2	2011	It is formed from L-arginine by NOS isoforms (nNOS, iNOS and eNOS).	Arginine	18-28	nitric oxide synthase 3	Homo sapiens	61-65
21172428-1	2011	The homodimeric flavohemeprotein endothelial nitric oxide synthase (eNOS) oxidizes l-arginine to l-citrulline and nitric oxide (NO), which acutely vasodilates blood vessels and inhibits platelet aggregation.	Arginine	83-93	nitric oxide synthase 3	Homo sapiens	68-72
21214862-9	2011	The results obtained in the present study demonstrate a direct link of early development with protein arginine methylation catalyzed by PRMT1.	Arginine	102-110	protein arginine methyltransferase 1	Danio rerio	136-141
21172428-8	2011	In addition, the related therapeutic possibilities such as supplementation with the eNOS substrate l-arginine, volatile NO, and direct NO donors as well as eNOS modulators such as the eNOS cofactor tetrahydrobiopterin and folic acid are discussed in detail.	Arginine	99-109	nitric oxide synthase 3	Homo sapiens	84-88
21273320-2	2011	At physiological concentrations (a 10-muM increase over background), the inhibitory effect of L-arginine is too weak to block feeding in hungry animals.	Arginine	94-104	latexin	Homo sapiens	38-41
21308737-2	2011	We have reported that L-arginine, released from extracellular substrates by prolactin (PRL)- and 17beta-estradiol (E2)-induced carboxypeptidase-D in the cell membrane, promotes nitric oxide (NO) production for MCF-7 cell survival.	Arginine	22-32	prolactin	Homo sapiens	87-90
20729006-5	2011	RESULTS: We found that the P53 72Arg/Arg genotype was associated with increased RP risk compared with the 72Pro/Pro genotype.	Arginine	33-36	tumor protein p53	Homo sapiens	27-30
21308737-3	2011	Arginine uptake is mediated by members of the cationic amino acid transporter (CAT) family and may coincide with induction of nitric oxide synthase (NOS) for the production of NO.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	126-147
21273320-3	2011	However, a 10-muM increase in L-arginine concentration acts along with another inhibitory stimulus, the sustained presence of food odor, to inhibit feeding after a period of access to food.	Arginine	30-40	latexin	Homo sapiens	14-17
21273320-6	2011	L-arginine is the substrate from which nitric oxide synthase (NOS) produces nitric oxide (NO).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	39-60
21273320-7	2011	Both an NO donor and a 10-muM increase in L-arginine inhibited biting in response to a weak food stimulus.	Arginine	42-52	latexin	Homo sapiens	26-29
21282198-12	2011	CONCLUSIONS: These findings suggest that both Sal B and Tan IIA have cardioprotective function in certain levels through multiple targets related with NO production, such as eNOS phosphorylation, L-arginine uptake and CAT expression, which may have major clinical implications.	Arginine	196-206	ATPase, class II, type 9A	Mus musculus	60-63
21262773-0	2011	Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	24-29
21262773-3	2011	We now show that the activity of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5).	Arginine	91-94	protein arginine methyltransferase 5	Homo sapiens	101-137
21262773-3	2011	We now show that the activity of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5).	Arginine	91-94	protein arginine methyltransferase 5	Homo sapiens	139-144
21282198-4	2011	We observed that Sal B and Tan IIA have cardioprotective effects in an in vivo myocardial infarction model of C57 mice, have vasodilator action in a ex vivo micro-artery system through the endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway and are involved in the regulation of the L-arginine/eNOS/NO pathways in human umbilical vein endothelial cells (HUVECs).	Arginine	298-308	ATPase, class II, type 9A	Mus musculus	31-34
21612679-13	2011	DNA sequencing of candidate gene CRYAA showed a heterozygous mutation c.34C &gt; T in exon 1, which led to condon 12 in peptide chain encoding arginine substituted by cysteine.	Arginine	143-151	crystallin alpha A	Homo sapiens	33-38
21288900-9	2011	In contrast, the ~160- and ~100-kDa fragments were from corin autocleavage at Arg-164 in frizzled 1 domain and Arg-427 in LDL receptor 5 domain, respectively.	Arginine	78-81	corin, serine peptidase	Homo sapiens	56-61
21314187-2	2011	A reduction in the net positive charge of myelin basic protein (MBP) via deimination of arginine to citrulline has been shown to correlate strongly with disease severity and has been linked to myelin instability and a defect that precedes neurodegeneration and leads to autoimmune attack.	Arginine	88-96	myelin basic protein	Bos taurus	42-62
21220428-6	2011	The orthosteric binding mode was verified by site-directed mutagenesis: replacement of orthosteric site arginine residues by alanine in FFA2 prevented ligand binding, and molecular modeling predicted the detailed mode of binding.	Arginine	104-112	free fatty acid receptor 2	Homo sapiens	136-140
21288900-9	2011	In contrast, the ~160- and ~100-kDa fragments were from corin autocleavage at Arg-164 in frizzled 1 domain and Arg-427 in LDL receptor 5 domain, respectively.	Arginine	111-114	corin, serine peptidase	Homo sapiens	56-61
21239484-5	2011	In C2C12 muscle cells, arginine withdrawal activated GCN2 signaling, without impacting mTORC1 signaling.	Arginine	23-31	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	53-57
21239484-6	2011	In F/A2 mice, the reduction of plasma and tissue arginine concentrations to ~25% of wild-type values activated GCN2 signaling, but mTORC1-mediated signaling remained unaffected.	Arginine	49-57	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	111-115
21247888-8	2011	Moreover, we demonstrate that Pmel17 function is independent of the sequence identity of its unconventional proprotein convertase-cleavage motif that lacks arginine in P4 position.	Arginine	156-164	premelanosome protein	Homo sapiens	30-36
21357744-3	2011	The p53 tumor suppressor protein, an important transcriptional regulator of apoptosis, naturally occurs in humans in two variants with single nucleotide polymorphisms resulting in Arg or Pro at residue 72.	Arginine	180-183	tumor protein p53	Homo sapiens	4-7
20641300-6	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	144-154
21357744-6	2011	In primary cultured neurons, Arg(72)-p53, but not Pro(72)-p53, interacted directly with mitochondrial Bcl-xL and activated the intrinsic apoptotic pathway, increasing vulnerability to ischemia-induced apoptotic cell death.	Arginine	29-32	tumor protein p53	Homo sapiens	37-40
21357744-6	2011	In primary cultured neurons, Arg(72)-p53, but not Pro(72)-p53, interacted directly with mitochondrial Bcl-xL and activated the intrinsic apoptotic pathway, increasing vulnerability to ischemia-induced apoptotic cell death.	Arginine	29-32	BCL2 like 1	Homo sapiens	102-108
21357744-7	2011	These results suggest that the Tp53 Arg/Arg genotype governs neuronal vulnerability to apoptosis and can be considered as a genetic marker predicting poor functional outcome after stroke.	Arginine	36-39	tumor protein p53	Homo sapiens	31-35
21357744-7	2011	These results suggest that the Tp53 Arg/Arg genotype governs neuronal vulnerability to apoptosis and can be considered as a genetic marker predicting poor functional outcome after stroke.	Arginine	40-43	tumor protein p53	Homo sapiens	31-35
21177244-6	2011	Further support for this idea was obtained by mutating NBD2 amino acids His(1364) and Arg(1367) at the CL5 interface, which also resulted in reduced MRP1 levels.	Arginine	86-89	ATP binding cassette subfamily B member 1	Homo sapiens	149-153
21257813-8	2011	The positive charge in K20 and the polar amide group in N27 appeared to interact with electronegative groups, since the replacement of these two residues with a positive (Arg) residue was well tolerated, while replacement with a negative (Asp) residue was detrimental to the bacteriocin activity.	Arginine	171-174	keratin 20	Homo sapiens	23-26
21448430-5	2011	Significantly reduced risk of EC was associated with TP53 genotypes for Arg/Arg + Arg/Pro vs Pro/Pro (OR = 0.73, 95% CI: 0.57-0.94, P = 0.014).	Arginine	72-75	tumor protein p53	Homo sapiens	53-57
21448430-5	2011	Significantly reduced risk of EC was associated with TP53 genotypes for Arg/Arg + Arg/Pro vs Pro/Pro (OR = 0.73, 95% CI: 0.57-0.94, P = 0.014).	Arginine	76-79	tumor protein p53	Homo sapiens	53-57
21448430-5	2011	Significantly reduced risk of EC was associated with TP53 genotypes for Arg/Arg + Arg/Pro vs Pro/Pro (OR = 0.73, 95% CI: 0.57-0.94, P = 0.014).	Arginine	76-79	tumor protein p53	Homo sapiens	53-57
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Arginine	166-174	ORAI calcium release-activated calcium modulator 3	Homo sapiens	118-123
21217072-7	2011	Interestingly, we found that the presence of N(G)-hydroxy-L-arginine (10 muM), a selective inhibitor of arginase or application of L-arginine (3 mM), restored ACh-induced coronary dilations only in patients with DM (to 47 +- 6% and to 40 +- 19%, respectively) but not in subjects without DM.	Arginine	58-68	latexin	Homo sapiens	73-76
21360837-2	2011	Here, we present experiments, using bovine serum albumin (BSA), lysozyme (LYZ), and beta-lactoglobulin (BLG) as model proteins, to show that arginine can enhance heat-induced aggregation of concentrated protein solutions, contrary to the conventional belief that arginine is a universal suppressor of aggregation.	Arginine	141-149	albumin	Homo sapiens	43-56
21360837-2	2011	Here, we present experiments, using bovine serum albumin (BSA), lysozyme (LYZ), and beta-lactoglobulin (BLG) as model proteins, to show that arginine can enhance heat-induced aggregation of concentrated protein solutions, contrary to the conventional belief that arginine is a universal suppressor of aggregation.	Arginine	141-149	lysozyme	Homo sapiens	64-72
21360837-2	2011	Here, we present experiments, using bovine serum albumin (BSA), lysozyme (LYZ), and beta-lactoglobulin (BLG) as model proteins, to show that arginine can enhance heat-induced aggregation of concentrated protein solutions, contrary to the conventional belief that arginine is a universal suppressor of aggregation.	Arginine	141-149	lysozyme	Homo sapiens	74-77
21123835-3	2011	Furthermore, prior research suggests that TP53 mutations preferentially occur on the arginine allele to selectively inactivate the p63 pathway.	Arginine	85-93	tumor protein p53	Homo sapiens	42-46
21039601-2	2011	In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine.	Arginine	155-165	nitric oxide synthase 2	Homo sapiens	85-90
21039601-2	2011	In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine.	Arginine	155-165	nitric oxide synthase 3	Homo sapiens	96-100
21228753-11	2011	However, the glycemic response to oral glucose tolerance testing, the acute insulin response to glucose, and the acute insulin response to arginine did not differ significantly between islet allograft and autograft recipients.	Arginine	139-147	insulin	Homo sapiens	119-126
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Arginine	263-266	tumor protein p53	Homo sapiens	32-35
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Arginine	267-270	tumor protein p53	Homo sapiens	32-35
21043833-10	2011	Interactions of betel quid with p53 genotypes in lung cancer showed significant increase for all the three genotypes, indicating a major role of betel quid (OR=5.90, CI=1.67-20.81, p=0.006; OR=5.44, CI=1.67-17.75, p=0.005; and OR=5.84, CI=1.70-19.97, p=0.005 for Arg/Arg, Arg/Pro, and Pro/Pro, respectively).	Arginine	267-270	tumor protein p53	Homo sapiens	32-35
21354047-4	2011	A somatic mutation in gene GNAS encoding the alpha subunit of the G protein (Gsalpha) involving the codon corresponding to Arg 201 has been identified in FD and is specifically absent in other BFOLs.	Arginine	123-126	GNAS complex locus	Homo sapiens	27-31
21354047-4	2011	A somatic mutation in gene GNAS encoding the alpha subunit of the G protein (Gsalpha) involving the codon corresponding to Arg 201 has been identified in FD and is specifically absent in other BFOLs.	Arginine	123-126	GNAS complex locus	Homo sapiens	77-84
21159997-4	2011	First, the NO-donor S-nitroso-N-acetylpenicillamine (SNAP; 10 nM) and the NO-precursor L-arginine (10 mM) were both able to increase NCX1 activity in a cGMP-independent way.	Arginine	87-97	solute carrier family 8 member A1	Homo sapiens	133-137
20972222-9	2011	Functional analyses of structure-based mutants revealed the essential Arg residues participating in tRNA recognition by TYW5.	Arginine	70-73	tRNA-yW synthesizing protein 5	Homo sapiens	120-124
21123178-4	2011	RHA contains a conserved ATPase-dependent helicase core that is flanked by two alpha-beta-beta-beta-alpha double-stranded RNA-binding domains at the N terminus and repeated arginine-glycine residues at the C terminus.	Arginine	173-181	DExH-box helicase 9	Homo sapiens	0-3
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	84-90
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	92-97
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	230-236
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 2	Homo sapiens	248-253
21271713-8	2011	In serum-free medium, the Arg(8) complex was cytotoxic (IC(50) 33 muM) and appears to be a rare example of a bioactive organometallic peptide conjugate.	Arginine	26-29	latexin	Homo sapiens	66-69
21257711-6	2011	Notably, Arg overexpression in Src knockdown cells can partially rescue actin polymerization in invadopodia while Src overexpression cannot compensate for loss of Arg, arguing that Src indirectly regulates invadopodium maturation through Arg activation.	Arginine	9-12	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	31-34
21146884-4	2011	The association between BMI and diabetes depends on p53 polymorphism: Odds Ratio shows a high significant association between BMI and diabetes in *Arg/*Arg subjects (p=0.00001).	Arginine	147-150	tumor protein p53	Homo sapiens	52-55
21146884-4	2011	The association between BMI and diabetes depends on p53 polymorphism: Odds Ratio shows a high significant association between BMI and diabetes in *Arg/*Arg subjects (p=0.00001).	Arginine	152-155	tumor protein p53	Homo sapiens	52-55
21460415-1	2011	The competition between arginases and NO synthases (NOS) for their common substrate L-arginine can be important in the airways hyperreactivity.	Arginine	84-94	nitric oxide synthase 2	Homo sapiens	38-50
21144910-8	2011	Substitution by either alanine or arginine exerted an almost identical effect on LRP binding.	Arginine	34-42	LDL receptor related protein 1	Homo sapiens	81-84
21292446-1	2011	BACKGROUND: L-Arginine (L-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes.	Arginine	12-22	nitric oxide synthase 2	Homo sapiens	179-183
21292446-1	2011	BACKGROUND: L-Arginine (L-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes.	Arginine	12-17	nitric oxide synthase 2	Homo sapiens	179-183
21292446-8	2011	CONCLUSIONS: Overexpression of L-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs.	Arginine	31-36	nitric oxide synthase 2	Homo sapiens	66-70
21167175-6	2011	The lesion is driven to an extrahelical position, and the incorporation of a C is mediated by an arginine (Arg324) that is conserved in all known orthologs of Rev1, including humans.	Arginine	97-105	REV1 DNA directed polymerase	Homo sapiens	159-163
21125212-2	2011	The molecular target of AK-ATP is Arg 34 of the Zn finger I of PARP-1, which is also a site for cation-pi interactions as a target of pi-electron donors.	Arginine	34-37	poly(ADP-ribose) polymerase 1	Homo sapiens	63-69
21182301-3	2011	P-glycoprotein (P-gp) is a useful model to identify mechanisms that repair processing defects because numerous arginine suppressor mutations have been identified in the TM segments.	Arginine	111-119	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
21182301-3	2011	P-glycoprotein (P-gp) is a useful model to identify mechanisms that repair processing defects because numerous arginine suppressor mutations have been identified in the TM segments.	Arginine	111-119	ATP binding cassette subfamily B member 1	Homo sapiens	16-20
20717004-3	2011	In sensitive cancer cells arginine starvation led to the activation of caspase-9, caspase-3 and caspase-7, cleavage of reparation enzyme, polyADP ribosyl polymerase, and DNA fragmentation, which are the typical hallmarks of intrinsic apoptosis realized by the mitochondrial pathway.	Arginine	26-34	caspase 3	Homo sapiens	82-91
20673806-6	2011	The gat1 mutant exhibited impaired growth on all amino acids tested as sole nitrogen sources, with the exception of arginine and proline.	Arginine	116-124	solute carrier family 6 member 1	Homo sapiens	4-8
21148698-1	2011	This study demonstrates a functional twin-arginine (Tat) translocation pathway present in the tsetse fly symbiont Sodalis glossinidius and its potential to export active heterologous proteins to the periplasm.	Arginine	42-50	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	52-55
20958291-7	2011	The three ligand classes acted orthosterically with respect to each other, suggesting overlapping binding sites and, consistent with this, mutation to alanine of the conserved arginine at position 3.36 or tyrosine 3.32 in transmembrane domain III abolished beta-arrestin-2 recruitment in response to each ligand at each orthologue.	Arginine	176-184	arrestin beta 2	Homo sapiens	257-272
21038436-0	2011	Role of pocket flexibility in the modulation of estrogen receptor alpha by key residue arginine 394.	Arginine	87-95	estrogen receptor 1	Homo sapiens	48-71
21038436-9	2011	Considering the sidechain flexibility in the ligand binding pocket, 17alpha-ethylestradiol-3-cyclopentylether was reported to correlate highly significantly with known induced fit conformational changes based upon proof-of-principle calculations on human ERalpha with the preservation of a strong salt bridge between glutamic acid 353 and arginine 394.	Arginine	339-347	estrogen receptor 1	Homo sapiens	255-262
21154234-7	2011	Treatment with L-arginine or SMT showed a significant reduction in CCl4-induced expression of these pro-fibrogenic factors, TNF-alpha and COX-2.	Arginine	15-25	tumor necrosis factor	Mus musculus	124-133
20419384-4	2011	PCR amplification for the analysis of p53 codon 72 arginine/proline alleles was carried out in a separate reaction.	Arginine	51-59	tumor protein p53	Homo sapiens	38-41
21257055-11	2011	Mammary uptake of energetic substrates did not vary across treatments, although milk lactose yield increased with the ARG+ treatment relative to CTL.	Arginine	118-121	Weaning weight-maternal milk	Bos taurus	80-84
21456131-1	2011	The poly(L-Arginine)(PArg)-multiwalled carbon nanotubes (MWCNTs) composite film was used to modify glassy carbon electrode (GCE) to fabricate PArg/MWCNTs/GCE through electropolymerization of L-Arginine on MWCNTs/GCE.	Arginine	9-19	poly(ADP-ribose) glycohydrolase	Homo sapiens	21-25
21257055-1	2011	This study was undertaken to determine if a limited supply of Arg would alter milk and milk protein yields, as well as mammary uptake of AA and energetic substrates.	Arginine	62-65	Weaning weight-maternal milk	Bos taurus	78-82
21257055-1	2011	This study was undertaken to determine if a limited supply of Arg would alter milk and milk protein yields, as well as mammary uptake of AA and energetic substrates.	Arginine	62-65	Weaning weight-maternal milk	Bos taurus	87-91
21257055-6	2011	Milk protein yield was increased by the ARG+ compared with the CTL treatment and deletion of Arg in the infusate (ARG-) did not impair this response.	Arginine	40-43	Weaning weight-maternal milk	Bos taurus	0-4
21257055-7	2011	Deletion of Arg from the EAA mixture decreased the mammary uptake of Arg relative to that of the CTL treatment, and although the uptake:output ratio decreased from 2.52 (ARG+) to 2.12 (ARG-), it was still largely in excess of Arg secretion in milk protein.	Arginine	12-15	Weaning weight-maternal milk	Bos taurus	243-247
21191143-6	2011	Plasma growth hormone increased to a greater degree after exercise in the ARG trial than CON trial (P &lt; 0.05).	Arginine	74-77	growth hormone 1	Homo sapiens	7-21
21456131-1	2011	The poly(L-Arginine)(PArg)-multiwalled carbon nanotubes (MWCNTs) composite film was used to modify glassy carbon electrode (GCE) to fabricate PArg/MWCNTs/GCE through electropolymerization of L-Arginine on MWCNTs/GCE.	Arginine	9-19	poly(ADP-ribose) glycohydrolase	Homo sapiens	142-146
21258366-0	2011	Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.	Arginine	18-21	epidermal growth factor receptor	Homo sapiens	89-93
21271567-11	2011	CONCLUSIONS: These results indicate that arginase I and II may play a role in the pathophysiology of allergic rhinitis, and suggest the possible role of the L-arginine metabolic pathway through modulation of L-arginine availability as a substrate for nitric oxide synthase (NOS) and arginase in the pathogenesis of allergic rhinitis.	Arginine	157-167	nitric oxide synthase 2	Homo sapiens	251-272
21258366-4	2011	Here, we show that EGFR Arg 1175 is methylated by an arginine methyltransferase, PRMT5.	Arginine	24-27	epidermal growth factor receptor	Homo sapiens	19-23
21258366-4	2011	Here, we show that EGFR Arg 1175 is methylated by an arginine methyltransferase, PRMT5.	Arginine	24-27	protein arginine methyltransferase 5	Homo sapiens	81-86
21258366-5	2011	Arg 1175 methylation positively modulates EGF-induced EGFR trans-autophosphorylation at Tyr 1173, which governs ERK activation.	Arginine	0-3	epidermal growth factor receptor	Homo sapiens	54-58
21258366-6	2011	Abolishment of Arg 1175 methylation enhances EGF-stimulated ERK activation by reducing SHP1 recruitment to EGFR, resulting in augmented cell proliferation, migration and invasion of EGFR-expressing cells.	Arginine	15-18	epidermal growth factor receptor	Homo sapiens	107-111
21258366-6	2011	Abolishment of Arg 1175 methylation enhances EGF-stimulated ERK activation by reducing SHP1 recruitment to EGFR, resulting in augmented cell proliferation, migration and invasion of EGFR-expressing cells.	Arginine	15-18	epidermal growth factor receptor	Homo sapiens	182-186
21258366-7	2011	Therefore, we propose a model in which the regulatory crosstalk between PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation.	Arginine	87-90	protein arginine methyltransferase 5	Homo sapiens	72-77
21258366-7	2011	Therefore, we propose a model in which the regulatory crosstalk between PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation.	Arginine	87-90	epidermal growth factor receptor	Homo sapiens	160-164
20946190-2	2011	The new allele differs from the sequence of HLA-A*02:01:01:01 only by a non-synonymous nucleotide exchange of Guanin (G)   Cytosin (C) at position 199 in exon 3 replacing amino acid (AA) Arginine (Arg, R) by Threonine (Thr, T) in codon 157.	Arginine	187-195	major histocompatibility complex, class I, A	Homo sapiens	44-49
21265888-0	2011	Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development.	Arginine	71-79	carbamoyl phosphate synthetase B	Arabidopsis thaliana	12-16
21265888-0	2011	Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development.	Arginine	71-79	carbamoyl phosphate synthetase A	Arabidopsis thaliana	21-25
21265888-2	2011	We performed a metabolomic analysis of one ven6 (venosa6) and three ven3 reticulate mutants that revealed altered levels of arginine precursors, namely increased ornithine and reduced citrulline levels.	Arginine	124-132	carbamoyl phosphate synthetase B	Arabidopsis thaliana	68-72
21265888-4	2011	Taken together, these results indicate that ven3 and ven6 mutants experience a blockage of the conversion of ornithine into citrulline in the arginine pathway.	Arginine	142-150	carbamoyl phosphate synthetase B	Arabidopsis thaliana	44-48
21265888-4	2011	Taken together, these results indicate that ven3 and ven6 mutants experience a blockage of the conversion of ornithine into citrulline in the arginine pathway.	Arginine	142-150	carbamoyl phosphate synthetase A	Arabidopsis thaliana	53-57
21265888-6	2011	Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), which is assumed to be required for the conversion of ornithine into citrulline in arginine biosynthesis.	Arginine	206-214	carbamoyl phosphate synthetase B	Arabidopsis thaliana	34-38
21265888-6	2011	Map-based cloning showed that the VEN3 and VEN6 genes encode subunits of Arabidopsis carbamoyl phosphate synthetase (CPS), which is assumed to be required for the conversion of ornithine into citrulline in arginine biosynthesis.	Arginine	206-214	carbamoyl phosphate synthetase A	Arabidopsis thaliana	43-47
21265888-8	2011	Detailed study of the reticulate leaf phenotype in the ven3 and ven6 mutants revealed that mesophyll development is highly sensitive to impaired arginine biosynthesis.	Arginine	145-153	carbamoyl phosphate synthetase B	Arabidopsis thaliana	55-59
21265888-8	2011	Detailed study of the reticulate leaf phenotype in the ven3 and ven6 mutants revealed that mesophyll development is highly sensitive to impaired arginine biosynthesis.	Arginine	145-153	carbamoyl phosphate synthetase A	Arabidopsis thaliana	64-68
20946190-2	2011	The new allele differs from the sequence of HLA-A*02:01:01:01 only by a non-synonymous nucleotide exchange of Guanin (G)   Cytosin (C) at position 199 in exon 3 replacing amino acid (AA) Arginine (Arg, R) by Threonine (Thr, T) in codon 157.	Arginine	187-190	major histocompatibility complex, class I, A	Homo sapiens	44-49
21187067-0	2011	TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.	Arginine	92-100	FUS RNA binding protein	Homo sapiens	0-3
21342627-10	2011	L-Arg treatment decreased significantly the Pax2 expression in 2-months- and 3-months-old rats when compared with the untreated IUGR group (P&lt;0.05).	Arginine	0-5	paired box 2	Rattus norvegicus	44-48
21342627-12	2011	Pax2 protein expression in 2-months- and 3-months-old pup rats from the IUGR and L-Arg treated groups increased significantly compared with normal controls.	Arginine	81-86	paired box 2	Rattus norvegicus	0-4
21342627-13	2011	Pax2 protein expression in the pup rats from the L-Arg treated group was significantly lower than that in the untreated IUGR pup rats (P&lt;0.01).	Arginine	49-54	paired box 2	Rattus norvegicus	0-4
21342627-15	2011	L-Arg treatment can decrease the expression of Pax2.	Arginine	0-5	paired box 2	Rattus norvegicus	47-51
21342627-0	2011	[Effect of L-arginine on Pax2 expression in the kidneys of pup rats with intrauterine growth retardation].	Arginine	11-21	paired box 2	Rattus norvegicus	25-29
21342627-1	2011	OBJECTIVE: To study the effect of L-arginine (L-Arg) on Pax2 expression in the kidneys of pup rats with intrauterine growth retardation (IUGR).	Arginine	34-44	paired box 2	Rattus norvegicus	56-60
21342627-1	2011	OBJECTIVE: To study the effect of L-arginine (L-Arg) on Pax2 expression in the kidneys of pup rats with intrauterine growth retardation (IUGR).	Arginine	46-51	paired box 2	Rattus norvegicus	56-60
21342627-8	2011	Pax2 positive cells were found in renal glomerulus and kidney tubules of 2-months- and 3-months-old rats from the IUGR and L-Arg treated groups.	Arginine	123-128	paired box 2	Rattus norvegicus	0-4
21106532-2	2011	Recent studies demonstrated that LSS also increases the expression of argininosuccinate synthetase 1 (ASS1) that regulates the provision of L-arginine, the substrate of NOS3.	Arginine	140-150	nitric oxide synthase 3	Homo sapiens	169-173
21283586-3	2011	The mechanism for this alkalinization-dependent gating has been proposed to be the neutralization of the side chain of a single arginine (lysine in TALK-2) residue near the pore of TASK-2, which occurs with the unusual pK(a) of 8.0.	Arginine	128-136	potassium two pore domain channel subfamily K member 17	Homo sapiens	148-154
21081503-3	2011	The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins.	Arginine	140-148	protein arginine methyltransferase 5	Homo sapiens	10-15
21081503-3	2011	The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins.	Arginine	140-148	protein arginine methyltransferase 5	Homo sapiens	36-41
21081503-3	2011	The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins.	Arginine	140-148	chloride nucleotide-sensitive channel 1A	Homo sapiens	104-109
21187067-0	2011	TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.	Arginine	92-100	FUS RNA binding protein	Homo sapiens	88-91
21187067-4	2011	We analyzed the methylation status of endogenous TLS and demonstrated that TLS was arginine-methylated by PRMT1.	Arginine	83-91	FUS RNA binding protein	Homo sapiens	49-52
21187067-4	2011	We analyzed the methylation status of endogenous TLS and demonstrated that TLS was arginine-methylated by PRMT1.	Arginine	83-91	FUS RNA binding protein	Homo sapiens	75-78
21187067-5	2011	Using mass spectrometry, we identified that four arginine residues within TLS (R216, R218, R242 and R394) were consistently dimethylated.	Arginine	49-57	FUS RNA binding protein	Homo sapiens	74-77
21187067-6	2011	We performed luciferase reporter assays to assess the functional consequence of TLS arginine methylation in transcriptional regulation and, interestingly, observed that TLS and PRMT1 synergistically coactivated transcription at the survivin promoter.	Arginine	84-92	FUS RNA binding protein	Homo sapiens	80-83
21187067-6	2011	We performed luciferase reporter assays to assess the functional consequence of TLS arginine methylation in transcriptional regulation and, interestingly, observed that TLS and PRMT1 synergistically coactivated transcription at the survivin promoter.	Arginine	84-92	FUS RNA binding protein	Homo sapiens	169-172
21187067-7	2011	Further analysis using a catalytic-dead PRMT1 or methylation inhibitor both showed that the synergistic transcriptional activation was mediated by TLS arginine-methylation.	Arginine	151-159	FUS RNA binding protein	Homo sapiens	147-150
21040785-5	2011	In GVHD patients, increasing arginine concentration resulted in down-regulation of IFNgamma and TNFalpha mRNA expression, whereas IL10 was up-regulated especially at physiological plasma levels (between 0 and 100 muM).	Arginine	29-37	interferon gamma	Homo sapiens	83-91
21245169-8	2011	Recruitment of BRCA1 to the p53-binding region of the p21 promoter in response to DNA damage required methylation of Arg 754 of p300 by CARM1.	Arginine	117-120	tumor protein p53	Homo sapiens	28-31
21245169-8	2011	Recruitment of BRCA1 to the p53-binding region of the p21 promoter in response to DNA damage required methylation of Arg 754 of p300 by CARM1.	Arginine	117-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	54-57
21040785-5	2011	In GVHD patients, increasing arginine concentration resulted in down-regulation of IFNgamma and TNFalpha mRNA expression, whereas IL10 was up-regulated especially at physiological plasma levels (between 0 and 100 muM).	Arginine	29-37	tumor necrosis factor	Homo sapiens	96-104
20966070-6	2011	Structural modeling highlights Ser-34 and Arg-98 as residues important for the assembly of the Myddosome, a death domain (DD) post-receptor complex involving the DD of MyD88, IRAK4, and IRAK2 or IRAK1.	Arginine	42-45	interleukin 1 receptor associated kinase 2	Homo sapiens	186-191
21141958-7	2011	Peroxidase assays of these heme-peptide complexes along with pH perturbations indicate that Arg(5) is a key second-sphere residue that H-bonds to the trans axial ligand and is responsible for the peroxidase activity of the heme-Abeta complexes.	Arginine	92-95	amyloid beta precursor protein	Homo sapiens	228-233
21047776-4	2011	Mutational studies indicate that the unusually high pH optimum can be partially ascribed to the presence of an arginine residue (Arg-795), corresponding in sequence alignments to the Glu-908 position at Ca(2+) binding site I of rabbit SERCA1a, but probably with an exposed position in LMCA1.	Arginine	111-119	sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	235-242
21047776-4	2011	Mutational studies indicate that the unusually high pH optimum can be partially ascribed to the presence of an arginine residue (Arg-795), corresponding in sequence alignments to the Glu-908 position at Ca(2+) binding site I of rabbit SERCA1a, but probably with an exposed position in LMCA1.	Arginine	129-132	sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	235-242
21116921-1	2011	L-arginine is a source of nitric oxide (NO) that is cleaved from the terminal guanidino nitrogen atom by nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	105-126
21249762-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
22393962-7	2011	CONCLUSIONS: Our results suggest that the codon 72 SNP which results in amino acid substitution of Arginine to Proline in cell cycle regulatory gene P53, is associated with sporadic CRC risk and carriers of Pro/Pro genotype and more than 50 years old may have high susceptibility.	Arginine	99-107	tumor protein p53	Homo sapiens	149-152
21846563-4	2011	Data is also available from numerous biotechnological studies wherein lysozyme has been employed as a model protein for recovering active recombinant protein from inclusion bodies using small molecules like l-arginine.	Arginine	207-217	lysozyme	Homo sapiens	70-78
21790217-3	2011	The ERE-linked p53 gene with the proline variant at codon 72 showed lower transfection rates than the gene without ERE or with the arginine variant at codon 72.	Arginine	131-139	tumor protein p53	Homo sapiens	15-18
21598212-6	2011	PCR amplification of TP53 codon 72 polymorphism: TP53 codon 72 genotypes were detected by PCR using specific primer pairs for amplifying the proline or the arginine Alleles.	Arginine	156-164	tumor protein p53	Homo sapiens	49-53
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Arginine	106-114	tumor protein p53	Homo sapiens	50-54
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Arginine	115-123	tumor protein p53	Homo sapiens	50-54
21598212-13	2011	In control samples, the genotype distribution for TP53 polymorphism showed 30.4%, 45.2% and 24.4% for the arginine/arginine, arginine/proline and proline/proline genotypes, respectively.	Arginine	115-123	tumor protein p53	Homo sapiens	50-54
21598212-18	2011	Overexpression of p53 was observed in 50.8 percent of cancer specimens which most of them were arginine/arginine genotype (P&lt;0.001).	Arginine	95-103	tumor protein p53	Homo sapiens	18-21
21598212-18	2011	Overexpression of p53 was observed in 50.8 percent of cancer specimens which most of them were arginine/arginine genotype (P&lt;0.001).	Arginine	104-112	tumor protein p53	Homo sapiens	18-21
21672450-4	2011	However, only few reports have shown an association between the Arginine (R) variant at position 52 of p53 and increased susceptibility to HPV E6 mediated degradation and thus to increased cancer susceptibility.	Arginine	64-72	tumor protein p53	Homo sapiens	103-106
21672450-7	2011	This variant seems to be differently segregated in different ethnic/geographical locations; therefore, there might be a possible role of this genetic variant associated with a certain genetic background, which can explain why some studies reveal increased risk of cervical cancer development associated with Arginine p53 variant.	Arginine	308-316	tumor protein p53	Homo sapiens	317-320
22292621-2	2011	In exon 4 of the gene TP53, a codon 72 polymorphism causing an Arg/Pro substitution has been reported in breast and other cancers.	Arginine	63-66	tumor protein p53	Homo sapiens	22-26
20844282-7	2011	Western blot analyses of whole oTr cell extracts revealed that Arg, Leu, and glucose, but not Gln, increased phosphorylated AKT1 by 2.8-, 2.5-, and 1.8-fold, respectively, within 15 min, and the increase was maintained to 60 min.	Arginine	63-66	AKT serine/threonine kinase 1	Homo sapiens	124-128
20844282-12	2011	Collectively, these results indicate that Arg, Leu, and glucose, but not Gln, in histotroph coordinately activate AKT1-mechanistic target of rapamycin and RPS6K-RPS6 cell signaling pathways to stimulate hypertrophy, hyperplasia, and migration of oTr cells.	Arginine	42-45	AKT serine/threonine kinase 1	Homo sapiens	114-118
22101376-8	2011	The individuals carrying the heterozygous genotype (Arg/Trp-Arg/Gln) in the p53 codon 248 polymorphism showed high BC risk (p &lt; 0.001).	Arginine	52-55	tumor protein p53	Homo sapiens	76-79
22101376-8	2011	The individuals carrying the heterozygous genotype (Arg/Trp-Arg/Gln) in the p53 codon 248 polymorphism showed high BC risk (p &lt; 0.001).	Arginine	60-63	tumor protein p53	Homo sapiens	76-79
21434831-3	2011	Sequence analysis of WT1 demonstrated a G-to-A substitution in exon 8 of the gene (c.1097G &gt; A), resulting in an arginine-to-histidine (R366H) substitution in the second zinc finger domain.	Arginine	116-124	WT1 transcription factor	Homo sapiens	21-24
21291370-1	2011	Nitric oxide (NO) is a diatomic free radical produced from L-arginine by constitutive and inducible nitric oxide synthase (cNOS and iNOS) in numerous mammalian cells and tissues.	Arginine	59-69	nitric oxide synthase 3	Homo sapiens	123-127
21196271-2	2011	Generated from L-arginine by the action of endothelial (or type 3) nitric oxide synthase (NOS3), NO regulates vascular tone in humans and causes endothelium-dependent vasodilation.	Arginine	15-25	nitric oxide synthase 3	Homo sapiens	90-94
21117918-4	2011	MAIN OUTCOME MEASURES: The GHRH-arginine test established GHD.	Arginine	32-40	growth hormone releasing hormone	Homo sapiens	27-31
22212723-4	2011	RESULTS: In subjects with the *Arg/*Arg genotype of p53 codon 72, no association was observed between CAD and PTPN22.	Arginine	31-34	tumor protein p53	Homo sapiens	52-55
22212723-4	2011	RESULTS: In subjects with the *Arg/*Arg genotype of p53 codon 72, no association was observed between CAD and PTPN22.	Arginine	36-39	tumor protein p53	Homo sapiens	52-55
22144986-2	2011	These alterations are seen as abnormal expression and activity of the cationic amino acid transporters and endothelial nitric oxide synthase isoform, that is, the "endothelial L-arginine/nitric oxide signalling pathway."	Arginine	176-186	nitric oxide synthase 3	Homo sapiens	107-140
21325775-10	2011	This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.	Arginine	52-60	apolipoprotein E	Homo sapiens	112-116
21797710-1	2011	We describe a high oxygen affinity hemoglobin (Hb) variant (Hb Vanderbilt) as a result of a heterozygous novel base change from T to A at codon 89 (AGT&gt;AGA) leading to an amino acid change from serine to arginine.	Arginine	207-215	angiotensinogen	Homo sapiens	148-151
21760660-6	2011	Also histopathology scoring showed that the liver injury was prevented and immunohistochemical iNOS activity was increased significantly in L-arginine group (P &lt;  .05).	Arginine	140-150	nitric oxide synthase 2	Rattus norvegicus	95-99
24453460-1	2011	Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO ) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding.	Arginine	46-56	calmodulin 1	Homo sapiens	146-156
24453460-1	2011	Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO ) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding.	Arginine	46-56	calmodulin 1	Homo sapiens	158-161
21921380-8	2011	We concluded she had RTH clinically, and we demonstrated by direct sequence analysis a mutation of the TRbeta gene, causing replacement of a glycine (G) with arginine (R) at codon 251.	Arginine	158-166	T cell receptor beta locus	Homo sapiens	103-109
20488579-6	2011	Driven by IFNgamma to express iNOS, macrophages suppressed T cell activation in vitro by arginine catabolism.	Arginine	89-97	interferon gamma	Mus musculus	10-18
21747870-3	2011	Through substrate competition, arginase decreases bioavailability of L-arginine for nitric oxide synthase (NOS), thereby limiting NO production with subsequent effects on airway tone and inflammation.	Arginine	69-79	nitric oxide synthase 2	Homo sapiens	84-105
21467726-3	2011	Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158.	Arginine	107-115	apolipoprotein E	Homo sapiens	72-77
21467726-3	2011	Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158.	Arginine	107-115	apolipoprotein E	Homo sapiens	132-136
21793404-2	2011	The results indicated that PNP at 250 mg/kg soil inhibited urease activity, nitrification potential, arginine ammonification rate and heterotrophic bacteria counts to some extents.	Arginine	101-109	purine nucleoside phosphorylase	Homo sapiens	27-30
21297920-5	2011	The protein arginine methylation elicited by carbon monoxide was attenuated by knocking down cystathionine beta-synthase with its small interfering RNA or by blocking S-adenosylhomocysteine hydrolase with adenosine dialdehyde, suggesting remethylation cycling is necessary to trigger the methylation processing.	Arginine	12-20	cystathionine beta-synthase	Homo sapiens	93-120
20530987-6	2011	The 2nd affected subject had a single missense mutation in the KAL1 gene, a T C transition in codon 163 that results in replacement of cysteine by arginine.	Arginine	147-155	anosmin 1	Homo sapiens	63-67
20811396-1	2011	Fibronectin (FN) is required for embryogenesis, morphogenesis, and wound repair, and its Arg-Gly-Asp-containing central cell-binding domain (CCBD) is essential for mesenchymal cell survival and growth.	Arginine	89-92	fibronectin 1	Homo sapiens	13-15
20811799-2	2011	IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production.	Arginine	236-244	interferon gamma	Homo sapiens	0-4
21986138-4	2011	IFN-gamma production was also measured after addition of L-arginine and/or antitransforming growth factor-beta (TGF-beta) neutralizing monoclonal antibody, and in PBMCs depleted of CD14(+)HLA-DR(-/low) cells.	Arginine	57-67	interferon gamma	Homo sapiens	0-9
20952238-7	2011	In the CYP2D6 gene, homozygosity for CYP2D6*10, which is associated with significantly reduced metabolic activity, was found in 3 cases, while 2 cases carried a different previously unreported missense mutation ((344)Arg&gt;Gln and (48)His&gt;Tyr).	Arginine	217-220	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	7-13
21625171-3	2011	However, arginine is also the substrate for a series of reactions leading to the synthesis of other AA and is an obligatory substrate for two enzymes with diverging actions, arginases and nitric oxide synthases (NOS), giving origin to urea and NO, respectively.	Arginine	9-17	nitric oxide synthase 2	Homo sapiens	188-210
21932578-5	2011	A large increase of p53 *Arg/*Arg was observed in T1D patients with age at onset &lt; 6 years.	Arginine	25-28	tumor protein p53	Homo sapiens	20-23
21932578-5	2011	A large increase of p53 *Arg/*Arg was observed in T1D patients with age at onset &lt; 6 years.	Arginine	30-33	tumor protein p53	Homo sapiens	20-23
20952238-7	2011	In the CYP2D6 gene, homozygosity for CYP2D6*10, which is associated with significantly reduced metabolic activity, was found in 3 cases, while 2 cases carried a different previously unreported missense mutation ((344)Arg&gt;Gln and (48)His&gt;Tyr).	Arginine	217-220	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	37-43
21738601-0	2011	A ribosomal misincorporation of Lys for Arg in human triosephosphate isomerase expressed in Escherichia coli gives rise to two protein populations.	Arginine	40-43	triosephosphate isomerase 1	Homo sapiens	53-78
20941622-3	2011	The three key mechanisms underlying the iNOS-dependent immunoregulation are (a) the modulation of signaling processes by NO, (b) the depletion of arginine, and (c) the alteration of accessory cell functions.	Arginine	146-154	nitric oxide synthase 2	Homo sapiens	40-44
21046201-1	2011	We previously demonstrated that enteral arginine increased c-Jun/activator protein-1 (AP-1) DNA-binding activity and iNOS expression in a rodent model of mesenteric ischemia/reperfusion (I/R).	Arginine	40-48	nitric oxide synthase 2	Rattus norvegicus	117-121
21046201-4	2011	Using a rodent model of mesenteric I/R we demonstrated that gut neutrophil infiltration, activity of c-Jun/AP-1, as well as iNOS expression were increased by I/R and further increased by arginine while lessened by inhibition of c-Jun using the pharmacologic c-Jun N-terminal kinase inhibitor, SP600125.	Arginine	187-195	nitric oxide synthase 2	Rattus norvegicus	124-128
20923691-4	2011	Here, we report the presence of (Arg(0), Trp(5), Leu(8))-bradykinin in the skin secretion of the European edible frog, Pelophylax kl.	Arginine	33-36	kininogen 1	Homo sapiens	57-67
20923691-10	2011	Synthetic (Arg(0), Trp(5), Leu(8))-bradykinin was previously reported as having multiphasic effects on arterial blood pressure in conscious trout and here we have demonstrated that it can antagonize the relaxation in rat arterial smooth muscle induced by canonical mammalian bradykinin.	Arginine	11-14	kininogen 1	Homo sapiens	35-45
20923691-10	2011	Synthetic (Arg(0), Trp(5), Leu(8))-bradykinin was previously reported as having multiphasic effects on arterial blood pressure in conscious trout and here we have demonstrated that it can antagonize the relaxation in rat arterial smooth muscle induced by canonical mammalian bradykinin.	Arginine	11-14	kininogen 1	Homo sapiens	275-285
20923691-11	2011	The discovery of (Arg(0), Trp(5), Leu(8))-bradykinin in the defensive skin secretion of this amphibian completes the spectrum of vertebrate taxon-specific BRPs identified from this source.	Arginine	18-21	kininogen 1	Homo sapiens	42-52
22194966-2	2011	This posttranslational modification of arginine was recently discovered on inflammatory chemokines including CXCL8 and CXCL10, and significantly reduced their biological activity.	Arginine	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
20695776-3	2011	During tissue development, repair, and regeneration of epithelial tissues, cells must interact with an interstitial fibronectin (Fn)-rich matrix, which has been shown to direct a more migratory/repair phenotype, presumably through interaction with Fn"s cell binding domain comprised of both synergy Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) sequences.	Arginine	311-314	fibronectin 1	Homo sapiens	116-127
21779349-3	2011	METHODS AND FINDINGS: Three COX-2 polymorphisms, including -1195G&gt;A (rs689466), -765G&gt;C (rs20417), and 587Gly&gt;Arg (rs3218625), were genotyped in 357 GCA patients and 985 controls.	Arginine	119-122	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	28-33
21695268-11	2011	Thus, whereas arginine and lysine substitutions in Cgap1p and Yap1p proteins were reported as responsible for a specific YRE-O or YRE-A preference, our analyses rather suggest that the ancestral yeast AP-1 protein could recognize both YRE-O and YRE-A motifs and that the arginine/lysine exchange is not the only determinant of the specialization of modern Yaps for one motif or another.	Arginine	14-22	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	62-67
21695268-11	2011	Thus, whereas arginine and lysine substitutions in Cgap1p and Yap1p proteins were reported as responsible for a specific YRE-O or YRE-A preference, our analyses rather suggest that the ancestral yeast AP-1 protein could recognize both YRE-O and YRE-A motifs and that the arginine/lysine exchange is not the only determinant of the specialization of modern Yaps for one motif or another.	Arginine	271-279	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	62-67
22219714-8	2011	Moreover, we demonstrated, for the first time that increased concentrations of L-arginine further potentiate iNOS-dependent O(2) ( -) formation in inflammatory macrophages.	Arginine	79-89	nitric oxide synthase 2, inducible	Mus musculus	109-113
20695776-3	2011	During tissue development, repair, and regeneration of epithelial tissues, cells must interact with an interstitial fibronectin (Fn)-rich matrix, which has been shown to direct a more migratory/repair phenotype, presumably through interaction with Fn"s cell binding domain comprised of both synergy Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) sequences.	Arginine	331-334	fibronectin 1	Homo sapiens	116-127
21179168-2	2010	In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor, from l-arginine (l-Arg) by means of electron transfer from NADPH through a flavin containing reductase domain to oxygen bound at the haem of an oxygenase domain, which also contains binding sites for tetrahydrobiopterin (BH(4)) and l-Arg.	Arginine	98-108	nitric oxide synthase 3	Homo sapiens	38-42
21179168-2	2010	In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor, from l-arginine (l-Arg) by means of electron transfer from NADPH through a flavin containing reductase domain to oxygen bound at the haem of an oxygenase domain, which also contains binding sites for tetrahydrobiopterin (BH(4)) and l-Arg.	Arginine	110-115	nitric oxide synthase 3	Homo sapiens	38-42
21179168-2	2010	In the presence of Ca(2+)/calmodulin, eNOS produces NO, endothelial-derived relaxing factor, from l-arginine (l-Arg) by means of electron transfer from NADPH through a flavin containing reductase domain to oxygen bound at the haem of an oxygenase domain, which also contains binding sites for tetrahydrobiopterin (BH(4)) and l-Arg.	Arginine	325-330	nitric oxide synthase 3	Homo sapiens	38-42
21089082-0	2010	Quantum-chemical and combined quantum-chemical/molecular-mechanical studies on the stabilization of a twin arginine pair in adenovirus Ad11.	Arginine	107-115	AD11	Homo sapiens	135-139
21172665-0	2010	TDRD3 is an effector molecule for arginine-methylated histone marks.	Arginine	34-42	tudor domain containing 3	Homo sapiens	0-5
21092923-6	2010	This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10).	Arginine	30-38	anoctamin 10	Homo sapiens	163-175
20870435-0	2010	Benign substitution (Aalpha289 Arg Gln) in the alphaC region of human fibrinogen.	Arginine	31-34	fibrinogen beta chain	Homo sapiens	70-80
21078563-0	2010	Insulin resistance in obesity and metabolic syndrome: is there a connection with platelet l-arginine transport?	Arginine	90-100	insulin	Homo sapiens	0-7
21078563-12	2010	DISCUSSION: Our study provides the first evidence that obesity and MetS lead to a dysfunction of L-arginine influx, which negatively correlates to insulin resistance.	Arginine	97-107	insulin	Homo sapiens	147-154
20937842-5	2010	In the present work, we show that matriptase-2 cleaves HJV at Arg(288), which produces one major soluble form of HJV.	Arginine	62-65	transmembrane serine protease 6	Homo sapiens	34-46
21092923-6	2010	This variant was a leucine-to-arginine substitution in the DUF 590 domain of a 16K transmembrane protein, a putative calcium-activated chloride channel encoded by anoctamin 10 (ANO10).	Arginine	30-38	anoctamin 10	Homo sapiens	177-182
20841502-0	2010	Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide.	Arginine	0-8	mechanistic target of rapamycin kinase	Sus scrofa	95-99
21204315-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	140-150
20841502-5	2010	Addition of arginine increased the activation of mTOR, p70 ribosomal protein S6 (p70 S6) kinase, and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) in a time- and dose-dependent manner.	Arginine	12-20	mechanistic target of rapamycin kinase	Sus scrofa	49-53
20841502-6	2010	The arginine-induced protein synthesis response was not inhibited by the NO inhibitors nitro-l-arginine methyl ester (l-NAME) and aminoguanidine, despite inducible NO synthase expression in IPEC-J2 cells.	Arginine	4-12	nitric oxide synthase 2	Sus scrofa	164-175
20841502-2	2010	Neonatal intestinal epithelial cells (IEC) are capable of arginine transport, catabolism, and synthesis and express nitric oxide (NO) synthase to produce NO from arginine.	Arginine	162-170	nitric oxide synthase 2	Sus scrofa	116-142
20841502-10	2010	We conclude that arginine-dependent cell survival and protein synthesis signaling in IPEC-J2 cells are mediated by mTOR, but not by NO.	Arginine	17-25	mechanistic target of rapamycin kinase	Sus scrofa	115-119
20935061-5	2010	Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pronounced in subgroups of non-smokers, non-drinkers, younger subjects (defined as &lt;=57 years), carriers of the TP53 Arg/Arg (rs1042522) genotype, patients with oropharyngeal cancer or late-stage SCCHN.	Arginine	216-219	tumor protein p53	Homo sapiens	211-215
21219031-3	2010	Albumin nanoparticles conjugated with a truncated fragment of fibronectin containing the Arg-Gly-Asp domain were successfully patterned and used as templates to elicit adhesion and spreading of human mesenchymal stem cells and fibroblasts.	Arginine	89-92	fibronectin 1	Homo sapiens	62-73
20935061-5	2010	Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pronounced in subgroups of non-smokers, non-drinkers, younger subjects (defined as &lt;=57 years), carriers of the TP53 Arg/Arg (rs1042522) genotype, patients with oropharyngeal cancer or late-stage SCCHN.	Arginine	220-223	tumor protein p53	Homo sapiens	211-215
20964645-5	2010	Porcine C-peptide was measured in urine samples under basal conditions and after stimulation with l-arginine.	Arginine	98-108	insulin	Homo sapiens	8-17
20964645-10	2010	Porcine C-peptide was present in all urine samples under basal conditions and increased post-stimulation with l-arginine.	Arginine	110-120	insulin	Homo sapiens	8-17
21092141-9	2010	Human Fbw7 mutants with mutations of arginine residues important for recognition of the CPD still ubiquitylated human c-Myb.	Arginine	37-45	F-box and WD repeat domain containing 7	Homo sapiens	6-10
20923854-1	2010	Nitric oxide (NO) is formed from arginine by the enzyme nitric oxide synthase (NOS).	Arginine	33-41	nitric oxide synthase 2	Homo sapiens	56-77
20923854-4	2010	In turn, arginine can be metabolized by the enzyme arginase, and ADMA by the enzyme dimethylarginine dimethylaminohydrolase (DDAH).	Arginine	9-17	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	84-123
20923854-4	2010	In turn, arginine can be metabolized by the enzyme arginase, and ADMA by the enzyme dimethylarginine dimethylaminohydrolase (DDAH).	Arginine	9-17	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	125-129
20690142-6	2010	Arg-Glc and His-Glc MRPs exhibited strong TAC and PPO inhibition.	Arginine	0-3	protoporphyrinogen oxidase	Homo sapiens	50-53
20309662-2	2010	The most commonly and extensively studied single nucleotide polymorphism (SNP) of p53 is Arg&gt;Pro substitution on codon 72 (R72P).	Arginine	89-92	tumor protein p53	Homo sapiens	82-85
20541608-2	2010	FMRP has two types of RNA binding domains, two K-homology domains and an arginine-glycine-glycine box domain, and it is proposed to act as a translation regulator of specific messenger RNA.	Arginine	73-81	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
20541608-5	2010	In addition, the in vitro and eukaryotic expression systems may produce FMRP which is posttranslationally modified, as phosphorylation and arginine methylation have been shown to occur on FMRP.	Arginine	139-147	fragile X messenger ribonucleoprotein 1	Homo sapiens	72-76
20541608-5	2010	In addition, the in vitro and eukaryotic expression systems may produce FMRP which is posttranslationally modified, as phosphorylation and arginine methylation have been shown to occur on FMRP.	Arginine	139-147	fragile X messenger ribonucleoprotein 1	Homo sapiens	188-192
20541608-7	2010	The expression of FMRP using E. coli renders the protein devoid of the posttranslational modifications of phosphorylation and arginine methylation, allowing the study of the direct effects of these modifications individually and simultaneously.	Arginine	126-134	fragile X messenger ribonucleoprotein 1	Homo sapiens	18-22
20541608-8	2010	In order to assure that FMRP retained activity throughout the process, we used fluorescence spectroscopy to assay the binding activity of the FMRP arginine-glycine-glycine box for the semaphorin 3F mRNA and confirmed that FMRP remained active.	Arginine	147-155	fragile X messenger ribonucleoprotein 1	Homo sapiens	24-28
20541608-8	2010	In order to assure that FMRP retained activity throughout the process, we used fluorescence spectroscopy to assay the binding activity of the FMRP arginine-glycine-glycine box for the semaphorin 3F mRNA and confirmed that FMRP remained active.	Arginine	147-155	fragile X messenger ribonucleoprotein 1	Homo sapiens	142-146
20541608-8	2010	In order to assure that FMRP retained activity throughout the process, we used fluorescence spectroscopy to assay the binding activity of the FMRP arginine-glycine-glycine box for the semaphorin 3F mRNA and confirmed that FMRP remained active.	Arginine	147-155	fragile X messenger ribonucleoprotein 1	Homo sapiens	142-146
21114867-2	2010	Endothelial NO, synthesized from L-arginine by endothelial NO synthase (eNOS), inhibits apoptosis and promotes angiogenesis, tumor cell proliferation and metastasis.	Arginine	33-43	nitric oxide synthase 3	Homo sapiens	72-76
20797433-2	2010	In the present study, using experimental COPD model rats, the therapeutic potential of a newly prepared respirable powder (RP) formulation of a long-acting VIP derivative, [Arg(15,20,21), Leu(17)]-VIP-GRR (IK312532), was assessed with a focus on pro-inflammatory biomarkers, morphological and histochemical changes, and infiltrated cells in the respiratory system.	Arginine	173-176	vasoactive intestinal peptide	Rattus norvegicus	197-200
20977583-4	2010	Genotyping of the IRS-1 Arg(972) variant was performed in type 2 diabetes patients treated with either sulphonylurea drugs, glinides or insulin or with metformin, acarbose or glitazones using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.	Arginine	24-27	insulin	Homo sapiens	136-143
20977583-6	2010	Furthermore, patients with secondary failure to insulinotropic hypoglycaemic drugs switching finally to insulin showed even higher HbA1c levels in carriers of Arg(972) compared to wild-type (8.7 vs. 7.6%, p = 0.005, independent t-test).	Arginine	159-162	insulin	Homo sapiens	48-55
20705916-5	2010	Addition of an NO donor (S-nitroso-N-acetylpenicillamine) and the NOS substrate l-arginine increased random cell migration (chemokinesis) and enhanced VEGF-dependent chemotaxis.	Arginine	80-90	vascular endothelial growth factor A	Homo sapiens	151-155
21086258-6	2010	The genotype p53Arg Arg was associated with a low risk for thyroid cancer (OR = 0.15; P &lt; 0.0001), indicating that the arginine allele in homozygosis could have a protective effect against carcinogenesis.	Arginine	122-130	tumor protein p53	Homo sapiens	13-16
20825172-7	2010	Reduced expression of proteins involved in NOS bioactivity (such as DDAH-1 and -2) suggested a role for the l-arginine/ADMA ratio in controlling VIC phenotypic profile.	Arginine	108-118	dimethylarginine dimethylaminohydrolase 1	Bos taurus	68-81
21103413-9	2010	A theoretical modeling of the corrected CD18 protein suggested that the replacement of the wild type arginine by gentamicin induced tryptophan at the position of the nonsense mutation, although enabled the expression of the entire CD18 protein, this was not sufficient to stabilize the CD18/11 heterodimer at the cell surface.	Arginine	101-109	integrin subunit beta 2	Homo sapiens	40-44
20797721-0	2010	Arginine end-functionalized poly(L-lysine) dendrigrafts for the stabilization and controlled release of insulin.	Arginine	0-8	insulin	Homo sapiens	104-111
20797721-4	2010	Stabilization of complexed insulin against enzymatic degradation by trypsin and alpha-chymotrypsin is observed especially for the highly arginine end-functionalized dendrigrafts.	Arginine	137-145	insulin	Homo sapiens	27-34
20797721-5	2010	Insulin release rates in simulated intestinal fluid are being controlled by the number of arginine end-groups and released insulin retains its conformation.	Arginine	90-98	insulin	Homo sapiens	0-7
20810653-5	2010	PRMT5 binds to the N terminus of srGAP2 (225-538 aa) and methylates its C-terminal arginine residue Arg-927.	Arginine	83-91	protein arginine methyltransferase 5	Homo sapiens	0-5
20810653-5	2010	PRMT5 binds to the N terminus of srGAP2 (225-538 aa) and methylates its C-terminal arginine residue Arg-927.	Arginine	100-103	protein arginine methyltransferase 5	Homo sapiens	0-5
21099335-5	2010	RESULTS: Arginine stimulated both glucagon and SST release from control mouse islets whereas the sympathetic neurotransmitter noradrenaline (NA) increased glucagon secretion but inhibited SST release in the presence of 2 mmol/l glucose or 20 mmol/l arginine.	Arginine	9-17	somatostatin	Mus musculus	47-50
20428984-7	2010	Interestingly, we also noted the upregulation of arginine-rich, mutated in early stage of tumours (ARMET) and cysteine-rich with EGF-like domain protein 2 (CRELD2) are two genes that have only recently been implicated in the UPR.	Arginine	49-57	cysteine-rich with EGF-like domains 2	Mus musculus	156-162
20724562-2	2010	We hypothesized that dietary supplementation with L-arginine, the substrate for NO synthase (NOS), would elicit similar responses.	Arginine	50-60	nitric oxide synthase 2	Homo sapiens	80-91
20833801-2	2010	In this study, the ldcA gene (lysine decarboxylase A; PA1818), previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism in this organism.	Arginine	120-130	lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA	Pseudomonas aeruginosa PAO1	19-23
20833801-3	2010	LdcA was purified to homogeneity from a recombinant strain of Escherichia coli, and the results of enzyme characterization revealed that this pyridoxal-5-phosphate-dependent decarboxylase takes L-lysine, but not L-arginine, as a substrate.	Arginine	212-222	lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA	Pseudomonas aeruginosa PAO1	0-4
20833801-5	2010	Contrarily, the ldcA promoter was induced by exogenous L-arginine but not by L-lysine in the wild-type strain PAO1, and the binding of ArgR to this promoter region was demonstrated by electromobility shift assays.	Arginine	55-65	lysine-specific pyridoxal 5'-phosphate-dependent carboxylase LdcA	Pseudomonas aeruginosa PAO1	16-20
21384570-2	2010	The p53 gene is characterized by Arg/Pro polymorphism in codon 72 whose alleles exhibit differential functional activity.	Arginine	33-36	tumor protein p53	Homo sapiens	4-7
20600019-3	2010	However, translation of inducible NO synthase (iNOS) and NO generation by H pylori-stimulated macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and is dependent on availability of the iNOS substrate L-arginine (L-Arg).	Arginine	244-254	nitric oxide synthase 2, inducible	Mus musculus	47-51
20600019-3	2010	However, translation of inducible NO synthase (iNOS) and NO generation by H pylori-stimulated macrophages is inhibited by the polyamine spermine derived from ornithine decarboxylase (ODC), and is dependent on availability of the iNOS substrate L-arginine (L-Arg).	Arginine	256-261	nitric oxide synthase 2, inducible	Mus musculus	47-51
20484304-8	2010	The AT-1 antagonist caused no change in the expression of renal ASS/ASL, but reduced renal and aortic arginase expression and renal arginase activity, which could explain the increased plasma L-Arg.	Arginine	192-197	angiotensin II receptor, type 1b	Rattus norvegicus	4-8
20484304-10	2010	CONCLUSION: Thus, the net result of AT-1 antagonist was an improved L-Arg to ADMA ratio due to the prevention of renal and vascular arginase activation which favours increased NO production.	Arginine	68-73	angiotensin II receptor, type 1b	Rattus norvegicus	36-40
20600019-4	2010	We determined if spermine inhibits iNOS-mediated immunity by reducing L-Arg uptake into macrophages.	Arginine	70-75	nitric oxide synthase 2, inducible	Mus musculus	35-39
20889542-0	2010	L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression.	Arginine	0-10	cyclin D3	Homo sapiens	33-42
20889542-4	2010	We sought to determine the mechanisms leading to a decreased cyclin D3 mRNA stability in activated T cells cultured in medium deprived of L-Arg.	Arginine	138-143	cyclin D3	Homo sapiens	61-70
20889542-5	2010	Results show that cyclin D3 mRNA instability induced by L-Arg deprivation is dependent on response elements found in its 3"-untranslated region (UTR).	Arginine	56-61	cyclin D3	Homo sapiens	18-27
20889542-6	2010	RNA-binding protein HuR was found to be increased in T cells cultured in medium with L-Arg and bound to the 3"-untranslated region of cyclin D3 mRNA in vitro and endogenously in activated T cells.	Arginine	85-90	cyclin D3	Homo sapiens	134-143
21055617-0	2010	Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging.	Arginine	23-26	proopiomelanocortin	Homo sapiens	46-82
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Arginine	79-82	proopiomelanocortin	Homo sapiens	108-144
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Arginine	79-82	proopiomelanocortin	Homo sapiens	146-155
21055617-1	2010	INTRODUCTION: The purpose of this study was to examine whether (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide targeting both melanocortin-1 (MC1) and alpha(v)beta(3) integrin receptors was superior in melanoma targeting to (99m)Tc-labeled alpha-MSH or RGD peptide targeting only the MC1 or alpha(v)beta(3) integrin receptor.	Arginine	79-82	proopiomelanocortin	Homo sapiens	301-310
21042587-3	2010	This phenotype exacerbated over time, cosegregates with the first heterozygous nonsense mutation p.R469[R,X] reported to date for the GR, replacing an arginine (CGA) by a stop (TGA) at amino-acid 469 in the second zinc finger of the DNA-binding domain of the receptor.	Arginine	151-159	nuclear receptor subfamily 3 group C member 1	Homo sapiens	134-136
21061495-2	2004	Ligands such as vitronectin, fibronectin, etc., which interact with integrins, are known to bind these receptors through an Arg-Gly-Asp (RGD) epitope.	Arginine	124-127	fibronectin 1	Homo sapiens	29-40
20650902-10	2010	On the other hand, point mutations of residues in the C-terminal leucine-rich repeat domain of Tmod3 (Lys-317 in the fifth leucine-rich repeat beta-sheet and Lys-344 or Arg-345/Arg-346 in the C-terminal alpha6-helix) significantly reduced pointed end-capping and nucleation without altering actin monomer binding.	Arginine	169-172	tropomodulin 3	Homo sapiens	95-100
20650902-10	2010	On the other hand, point mutations of residues in the C-terminal leucine-rich repeat domain of Tmod3 (Lys-317 in the fifth leucine-rich repeat beta-sheet and Lys-344 or Arg-345/Arg-346 in the C-terminal alpha6-helix) significantly reduced pointed end-capping and nucleation without altering actin monomer binding.	Arginine	177-180	tropomodulin 3	Homo sapiens	95-100
20974001-4	2010	L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.	Arginine	56-66	arginine vasopressin	Rattus norvegicus	78-80
20974001-4	2010	L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.	Arginine	56-66	angiotensinogen	Rattus norvegicus	197-203
21042587-3	2010	This phenotype exacerbated over time, cosegregates with the first heterozygous nonsense mutation p.R469[R,X] reported to date for the GR, replacing an arginine (CGA) by a stop (TGA) at amino-acid 469 in the second zinc finger of the DNA-binding domain of the receptor.	Arginine	151-159	chromogranin A	Homo sapiens	161-164
20847235-3	2010	We have detected heterozygous germline mutations in IDH2 that alter enzyme residue Arg(140) in 15 unrelated patients with d-2-hydroxyglutaric aciduria (D-2-HGA), a rare neurometabolic disorder characterized by supraphysiological levels of D-2-HG.	Arginine	83-86	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	52-56
20798359-4	2010	OBJECTIVE: To identify the potential role of STAT3 arginine methylation by PRMT2 in the regulation of leptin signaling and energy homeostasis.	Arginine	51-59	signal transducer and activator of transcription 3	Mus musculus	45-50
20798359-10	2010	CONCLUSIONS: These data elucidate a molecular pathway that directly links arginine methylation of STAT3 by PRMT2 to the regulation of leptin signaling, suggesting a potential role for PRMT2 antagonism in the treatment of obesity and obesity-related syndromes.	Arginine	74-82	signal transducer and activator of transcription 3	Mus musculus	98-103
20654742-7	2010	Like in other AdSS, a conserved arginine residue (Arg155) is involved in dimer crosstalk and interacts with IMP in the active site of the symmetry related subunit of PfAdSS.	Arginine	32-40	adenylosuccinate synthase 2	Homo sapiens	14-18
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	77-85	tumor protein p53	Homo sapiens	43-47
20427142-1	2010	A common polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.	Arginine	77-85	tumor protein p53	Homo sapiens	145-148
20427142-9	2010	Because of the presence of arginine, a selective trypsin proteolytic cleavage at R(72), giving rise to two selective shorter peptides, occurred in p53R(72), but was missing in the case of p53P(72) trypsin digest, in which an uncleaved longer peptide was instead identified.	Arginine	27-35	tumor protein p53	Homo sapiens	147-150
20577877-1	2010	The TP53 tumor suppressor gene contains a well-studied polymorphism that encodes either proline (P) or arginine (R) at codon 72, and over half of the world"s population is homozygous for R at this codon.	Arginine	103-111	tumor protein p53	Homo sapiens	4-8
20800479-3	2010	Durable type II inhibitors were designed which bind to arginines (Arg67 or Arg70) that function as key residues for mediating phospho-threonine 180 dependant conformational fluxing of p38-alpha from an inactive type II state to an active type I state.	Arginine	55-64	mitogen-activated protein kinase 14	Homo sapiens	184-193
20392549-9	2010	TI induced an alteration of macrophage mRNA expression of IL-6, TNF-alpha and iNOS, corrected in the TI-EN-Arg and TI-M-IED groups (p&lt;0.05), but not by the IED.	Arginine	107-110	interleukin 6	Rattus norvegicus	58-62
20532936-3	2010	Polymorphisms at codon 72 of p53 (arginine (Arg72) to proline transition) confers differences in mitochondrial translocation and apoptosis inducing capabilities of p53 in vitro.	Arginine	34-42	tumor protein p53	Homo sapiens	29-32
20634695-5	2010	Work studying molecular mechanisms indicates that 90% of the known mutations causing hypokalaemic periodic paralysis (HypoPP) result in loss of positively charged arginine residues in the S4 segments of either SCN4A or CACNA1S, possibly creating a gating-pore current that may be important in the pathogenesis of HypoPP.	Arginine	163-171	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	219-226
20532936-3	2010	Polymorphisms at codon 72 of p53 (arginine (Arg72) to proline transition) confers differences in mitochondrial translocation and apoptosis inducing capabilities of p53 in vitro.	Arginine	34-42	tumor protein p53	Homo sapiens	164-167
20412452-4	2010	Therefore, P53 Arg is an ameloblastoma-susceptible allele [OR (95% CI) = 2.06 (1.28-3.31), P = 0.002].	Arginine	15-18	tumor protein p53	Homo sapiens	11-14
20731414-8	2010	The main and primary cleavage sites were located in the N-terminal half of statherin, specifically after Arg(9), Arg(10), and Arg(13); after Phe(14) and Tyr(18); and after Gly(12), Gly(15), Gly(17) and Gly(19) while the C-terminal half of statherin remained intact.	Arginine	105-108	statherin	Homo sapiens	75-84
20731414-8	2010	The main and primary cleavage sites were located in the N-terminal half of statherin, specifically after Arg(9), Arg(10), and Arg(13); after Phe(14) and Tyr(18); and after Gly(12), Gly(15), Gly(17) and Gly(19) while the C-terminal half of statherin remained intact.	Arginine	113-116	statherin	Homo sapiens	75-84
20731414-8	2010	The main and primary cleavage sites were located in the N-terminal half of statherin, specifically after Arg(9), Arg(10), and Arg(13); after Phe(14) and Tyr(18); and after Gly(12), Gly(15), Gly(17) and Gly(19) while the C-terminal half of statherin remained intact.	Arginine	113-116	statherin	Homo sapiens	75-84
20558222-8	2010	This process was inhibited by substrates of cationic amino acid transporter (CAT)s, such as L-arginine, L-lysine, and L-ornithine.	Arginine	92-102	catalase	Rattus norvegicus	77-80
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	ras homolog family member A	Homo sapiens	118-122
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	ras homolog family member A	Homo sapiens	167-171
20412452-6	2010	Therefore, the increased risk associated with P53 Arg may not be influenced by either the sex of patients or clinical characteristics of the tumours.	Arginine	50-53	tumor protein p53	Homo sapiens	46-49
20412452-7	2010	Moreover, when compared with homozygous P53 Pro, people who carried the Arg allele had a remarkably high risk of developing ameloblastoma [adjusted OR (95% CI) = 7.26 (2.34-23.41), P &lt; 10(-3)].	Arginine	72-75	tumor protein p53	Homo sapiens	40-43
20412452-8	2010	CONCLUSION: The Arg allele of P53 gene codon 72 may increase susceptibility, and P53 may be important in the aetiology of ameloblastoma.	Arginine	16-19	tumor protein p53	Homo sapiens	30-33
20805563-6	2010	Mutations producing arginine substitutions were frequent and arose largely (66%) from base changes in just two codons: AGC and AGT.	Arginine	20-28	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	127-130
20647382-6	2010	While the NCAPG I442M mutation affected the arginine metabolism, the 204X allele in the GDF8 gene predominantly raised the carnitine level and had concordant effects on glycerophosphatidylcholines and sphingomyelins.	Arginine	44-52	non-SMC condensin I complex subunit G	Bos taurus	10-15
20669242-5	2010	These domains are known to recognize methylated lysine or arginine residues and could contribute to targeting of Pcl-PRC2.	Arginine	58-66	Polycomblike	Drosophila melanogaster	113-116
20669242-7	2010	Pcl-Tudor contains an atypical, incomplete aromatic cage that does not interact with known Tudor domain ligands, such as methylated lysines or arginines.	Arginine	143-152	Polycomblike	Drosophila melanogaster	0-9
20663104-1	2010	HLA-A*11:57 allele was different from HLA-A*11:16 by single nucleotide substitution at codon 145(CAC&gt;CGC), resulting in one amino acid change His to Arg.	Arginine	152-155	major histocompatibility complex, class I, A	Homo sapiens	0-5
20663104-1	2010	HLA-A*11:57 allele was different from HLA-A*11:16 by single nucleotide substitution at codon 145(CAC&gt;CGC), resulting in one amino acid change His to Arg.	Arginine	152-155	major histocompatibility complex, class I, A	Homo sapiens	38-43
21348305-6	2010	Peptides showed high ACE inhibitory activity when the N-terminal was hydrophobic amino acid such as Val and C-terminal tripeptide contained Phe, Trp or Arg.	Arginine	152-155	angiotensin I converting enzyme	Homo sapiens	21-24
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Arginine	77-80	tumor protein p53	Homo sapiens	69-72
20818810-6	2010	RESULTS: alpha,beta-amyrin and methylprednisolone treatments significantly (P &lt; 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6, as compared to the vehicle control.	Arginine	104-114	tumor necrosis factor	Rattus norvegicus	235-244
20687526-10	2010	In aggregate, our results suggest that the hydrogen bonding of arginine to TAR RNA dictates the binding interaction.	Arginine	63-71	RNA binding motif protein 8A	Homo sapiens	75-78
20818810-6	2010	RESULTS: alpha,beta-amyrin and methylprednisolone treatments significantly (P &lt; 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6, as compared to the vehicle control.	Arginine	104-114	interleukin 6	Rattus norvegicus	249-253
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Arginine	73-76	tumor protein p53	Homo sapiens	69-72
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Arginine	77-80	tumor protein p53	Homo sapiens	69-72
20732856-4	2010	We observed an increased risk of cervical cancer associated with the p53 Arg/Arg (OR, 2.25; 95% CI, 1.11-4.54) or p21 Ser/Ser (OR, 2.09; 95% CI, 1.04-4.19) genotype, compared with the p53 Pro/Pro or p21 Arg/Arg genotype, respectively.	Arginine	77-80	tumor protein p53	Homo sapiens	69-72
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	208-211	tumor protein p53	Homo sapiens	41-44
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	208-211	tumor protein p53	Homo sapiens	204-207
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	212-215	tumor protein p53	Homo sapiens	41-44
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	212-215	tumor protein p53	Homo sapiens	204-207
20550582-0	2010	An antioxidative mechanism mediated by the yeast N-acetyltransferase Mpr1: oxidative stress-induced arginine synthesis and its physiological role.	Arginine	100-108	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	69-73
21254629-2	2010	The NO-synthase inductor L-arginine and the inhibitor of nitric oxide synthesis, L-NAME, influenced on the amount of annexin-positive cells, the content of Bax protein, reactive oxygen species, cyclic nucleotides, and calcium homeostasis in neutrophils under conditions realizing programmed death during oxidative stress in vitro and under acute inflammation.	Arginine	25-35	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159
26443788-5	2010	Proteins are targeted to the Tat machinery by N-terminal signal peptides that contain a consensus twin arginine motif.	Arginine	103-111	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	29-32
26443788-6	2010	In Escherichia coli and Salmonella there are approximately thirty proteins with twin arginine signal peptides that are transported by the Tat pathway.	Arginine	85-93	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	138-141
20550582-7	2010	Under oxidative stress conditions, the transcription of PUT1 encoding the proline oxidase Put1 and MPR1 was strongly induced, and consequently, the arginine content was significantly increased.	Arginine	148-156	proline dehydrogenase	Saccharomyces cerevisiae S288C	56-60
20550582-7	2010	Under oxidative stress conditions, the transcription of PUT1 encoding the proline oxidase Put1 and MPR1 was strongly induced, and consequently, the arginine content was significantly increased.	Arginine	148-156	proline dehydrogenase	Saccharomyces cerevisiae S288C	90-94
20550582-9	2010	These results suggest that Mpr1-dependent arginine synthesis confers stress tolerance.	Arginine	42-50	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	27-31
20550582-10	2010	We propose an antioxidative mechanism that is involved in stress-induced arginine synthesis requiring Mpr1 and Put1.	Arginine	73-81	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	102-106
20550582-10	2010	We propose an antioxidative mechanism that is involved in stress-induced arginine synthesis requiring Mpr1 and Put1.	Arginine	73-81	proline dehydrogenase	Saccharomyces cerevisiae S288C	111-115
19481782-10	2010	The increased levels and activity of DDAH I and DDAH II enzymes following myocardial infarction suggest a potential role for them in local protection of NOS enzymes from inhibition by methylated arginines during infarct healing.	Arginine	195-204	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	37-43
20506214-8	2010	Incubation of wild-type P gingivalis with fibrinogen or alpha-enolase caused degradation of the proteins and citrullination of the resulting peptides at carboxy-terminal arginine residues, which were identified by mass spectrometry.	Arginine	170-178	fibrinogen beta chain	Homo sapiens	42-52
20541591-8	2010	CONCLUSION: Protein arginine dimethylations of hnRNPR, CstF-64, and TPI were regulated during HeLa cell cycle by respective PRMTs.	Arginine	20-28	triosephosphate isomerase 1	Homo sapiens	68-71
20541591-9	2010	GENERAL SIGNIFICANCE: These results suggest that regulation of arginine dimethylation of hnRNPR, CstF-64, and TPI at G0/G1 to G1 are most likely to modulate the cellular growth and proliferation in HeLa cell cycle.	Arginine	63-71	triosephosphate isomerase 1	Homo sapiens	110-113
20388249-0	2010	Effects of dietary arginine on inflammatory mediator and receptor of advanced glycation endproducts (RAGE) expression in rats with streptozotocin-induced type 2 diabetes.	Arginine	19-27	advanced glycosylation end product-specific receptor	Rattus norvegicus	101-105
20388249-2	2010	In vitro studies reported that Arg inhibits advanced glycation endproduct (AGE) formation; however, the effects of Arg on the receptor of AGE (RAGE) expression in inflammatory conditions are not clear.	Arginine	115-118	advanced glycosylation end product-specific receptor	Rattus norvegicus	143-147
20388249-3	2010	The present study investigated the effects of dietary Arg supplementation on inflammatory mediator production and RAGE expression in type 2 diabetic rats.	Arginine	54-57	advanced glycosylation end product-specific receptor	Rattus norvegicus	114-118
20388249-13	2010	These results suggest that supplemental dietary Arg can decrease AGE-RAGE interactions and consequently reduce tissue damage in rats with type 2 diabetes.	Arginine	48-51	advanced glycosylation end product-specific receptor	Rattus norvegicus	69-73
20421892-6	2010	Furthermore, PRMT5 methylates N-terminal arginines in GM130, and such arginine methylation appears critical for GA ribbon formation.	Arginine	41-50	protein arginine methyltransferase 5	Homo sapiens	13-18
20421892-6	2010	Furthermore, PRMT5 methylates N-terminal arginines in GM130, and such arginine methylation appears critical for GA ribbon formation.	Arginine	41-49	protein arginine methyltransferase 5	Homo sapiens	13-18
20421892-7	2010	Our findings reveal a molecular mechanism by which PRMT5-dependent arginine methylation of GM130 controls the maintenance of GA architecture.	Arginine	67-75	protein arginine methyltransferase 5	Homo sapiens	51-56
20012899-8	2010	l-arginine augmented and prolonged cold-induced UCP1 and nitrotyrosine immunopositivity, NF-kappaB activation and SODs mRNA expression increase, while l-NAME expressed an opposite effect.	Arginine	0-10	uncoupling protein 1	Rattus norvegicus	48-52
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Arginine	31-34	tumor protein p53	Homo sapiens	27-30
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Arginine	105-108	tumor protein p53	Homo sapiens	27-30
20827430-4	2010	However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.	Arginine	105-108	tumor protein p53	Homo sapiens	27-30
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Arginine	112-115	tumor protein p53	Homo sapiens	108-111
20550582-4	2010	Here, we report the synthesis of oxidative stress-induced arginine via P5C/GSA acetylation catalyzed by Mpr1.	Arginine	58-66	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	104-108
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Arginine	172-175	tumor protein p53	Homo sapiens	108-111
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Arginine	172-175	tumor protein p53	Homo sapiens	108-111
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Arginine	83-91	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	39-43
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Arginine	83-91	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	139-143
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Arginine	169-177	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	39-43
20550582-5	2010	Gene disruption analysis revealed that Mpr1 converts P5C/GSA into N-acetyl-GSA for arginine synthesis in the mitochondria, indicating that Mpr1 mediates the proline and arginine metabolic pathways.	Arginine	169-177	proteasome regulatory particle lid subunit RPN11	Saccharomyces cerevisiae S288C	139-143
20516147-9	2010	The MAD1L1 558 His/His genotype was also associated with 1.4-fold elevated lung cancer risk compared with the Arg/Arg genotype.	Arginine	110-113	mitotic arrest deficient 1 like 1	Homo sapiens	4-10
20516147-9	2010	The MAD1L1 558 His/His genotype was also associated with 1.4-fold elevated lung cancer risk compared with the Arg/Arg genotype.	Arginine	114-117	mitotic arrest deficient 1 like 1	Homo sapiens	4-10
20692206-3	2010	The heterozygous somatic mutations at arginine R132 (IDH1) and at R140 or R172 (IDH2) in the enzyme active site confer a gain of function to the enzymes, which can both produce the metabolite 2-hydroxyglutarate.	Arginine	38-46	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	80-84
19771536-4	2010	The purpose of this study was to examine whether p53 Arg at the polymorphic position 72 could represents a risk factor for women with high-risk HPV-associated malignant cervical lesions.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
20573782-5	2010	This cluster is expected to be altered upon VIP binding, because Arg(188) has been shown previously to interact with Asp(3) of VIP.	Arginine	65-68	vasoactive intestinal peptide	Homo sapiens	44-47
20573782-5	2010	This cluster is expected to be altered upon VIP binding, because Arg(188) has been shown previously to interact with Asp(3) of VIP.	Arginine	65-68	vasoactive intestinal peptide	Homo sapiens	127-130
20812283-3	2010	Inducible nitric oxide synthase (iNOS) represents one of the three isoforms that produce nitric oxide using L-arginine as a substrate in response to an increase in superoxide anion activated by NF-kB.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	0-31
20812283-3	2010	Inducible nitric oxide synthase (iNOS) represents one of the three isoforms that produce nitric oxide using L-arginine as a substrate in response to an increase in superoxide anion activated by NF-kB.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	33-37
20669954-1	2010	Nitric oxide synthase (NOS), a homodimeric enzyme with a flavin reductase domain and a P450-type heme-containing oxygenase domain, catalyzes the formation of NO from L-arginine, NADPH, and O(2) in a two-step reaction sequence.	Arginine	166-176	nitric oxide synthase 2	Homo sapiens	0-21
20736484-2	2010	The Akt, RSK, and p70 S6 family of protein kinases transmits signals by phosphorylating substrates on an RxRxxS/T motif (R, arginine; S, serine; T, threonine; and x, any amino acid).	Arginine	124-132	AKT serine/threonine kinase 1	Homo sapiens	4-7
20736484-2	2010	The Akt, RSK, and p70 S6 family of protein kinases transmits signals by phosphorylating substrates on an RxRxxS/T motif (R, arginine; S, serine; T, threonine; and x, any amino acid).	Arginine	124-132	ribosomal protein S6 kinase A2	Homo sapiens	9-12
20529840-6	2010	We conclude that the Arg(752)-Glu(47) bridging interaction is the main feature that enables CaM to activate nNOS.	Arginine	21-24	calmodulin 1	Homo sapiens	92-95
20405138-7	2010	After arginine administration, the maximal average GH concentration in serum at 30 min was also significantly lower in patients with MSA-p than in those with PD (4.07 +/- 0.80 vs. 7.89 +/- 1.29; P < 0.05) with a sensitivity and specificity of 78.26 and 73.08%.	Arginine	6-14	growth hormone 1	Homo sapiens	51-53
20405138-9	2010	However, when the clonidine and arginine were applied combined, the contrast of the maximal average GH concentration in serum in two groups was markedly increased (5.02 +/- 1.12 vs. 10.75 +/- 1.11; P < 0.05) with a sensitivity and specificity of 73.91 and 92.31%, and the specificity was notably increased in the combined GH stimulation test.	Arginine	32-40	growth hormone 1	Homo sapiens	100-102
20405138-9	2010	However, when the clonidine and arginine were applied combined, the contrast of the maximal average GH concentration in serum in two groups was markedly increased (5.02 +/- 1.12 vs. 10.75 +/- 1.11; P < 0.05) with a sensitivity and specificity of 73.91 and 92.31%, and the specificity was notably increased in the combined GH stimulation test.	Arginine	32-40	growth hormone 1	Homo sapiens	322-324
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Arginine	97-100	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Arginine	101-104	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Arginine	101-104	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Arginine	101-104	tumor protein p53	Homo sapiens	78-82
20630574-8	2010	However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians.	Arginine	101-104	tumor protein p53	Homo sapiens	78-82
19167766-6	2010	L-arginine supplementation had a significant effect on the nitrite levels, and EPC numbers, and inhibited vWF increment and atherosclerosis progression (p&lt;0.05).	Arginine	0-10	LOW QUALITY PROTEIN: von Willebrand factor	Oryctolagus cuniculus	106-109
20551327-5	2010	We show that the serine protease matriptase is an efficient, but not essential, cellular processor of CDCP1 at Arg-368.	Arginine	111-114	coagulation factor II, thrombin	Homo sapiens	17-32
20716762-2	2010	Because the production of nitric oxide (NO) from arginine by the inducible isoform of NO synthase (iNOS) in activated macrophages is essential for host defense against many pathogens, arginine availability is a critical determinant of resistance to infection.	Arginine	49-57	nitric oxide synthase 2	Homo sapiens	99-103
20716762-2	2010	Because the production of nitric oxide (NO) from arginine by the inducible isoform of NO synthase (iNOS) in activated macrophages is essential for host defense against many pathogens, arginine availability is a critical determinant of resistance to infection.	Arginine	184-192	nitric oxide synthase 2	Homo sapiens	99-103
20716763-0	2010	TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.	Arginine	77-85	toll-like receptor 4	Mus musculus	48-52
20716763-6	2010	Supplementation of starved mice with arginine promoted the subsequent activation of ERK1/2 and the production of TNF-alpha in response to LPS.	Arginine	37-45	tumor necrosis factor	Mus musculus	113-122
20213438-6	2010	Real-time polymerase chain reaction and western blotting analyses revealed that both mRNA and protein levels for heat shock protein-70 (HSP70) were higher (P&lt;0.05) in the intestinal mucosae of Arg- or NCG-supplemented pigs than in the control group.	Arginine	196-199	heat shock 70 kDa protein 6	Sus scrofa	136-141
20703075-4	2010	We previously reported that the highly conserved p53 Arg(R)-174 is substituted by lysine (K) in Spalax, identical to a tumor-associated mutation.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
20650641-4	2010	Molecular modeling studies indicated that the azido substituent can be inserted deeply into the secondary pocket of COX-2 active site for interactions with Arg(513).	Arginine	156-159	prostaglandin-endoperoxide synthase 2	Homo sapiens	116-121
20213438-8	2010	Collectively, these results indicate that dietary supplementation with 0.6% Arg or 0.08% NCG enhances intestinal HSP70 gene expression, intestinal growth and integrity, and the availability of dietary nutrients for whole-body weight gain in postweaning pigs fed a CSM-based diet.	Arginine	76-79	heat shock 70 kDa protein 6	Sus scrofa	113-118
20204431-1	2010	This work examines the effects of L-arginine (L-Arg) on the aggregation and amyloid fibrillation of bovine serum albumin (BSA).	Arginine	34-44	albumin	Homo sapiens	107-120
20204431-1	2010	This work examines the effects of L-arginine (L-Arg) on the aggregation and amyloid fibrillation of bovine serum albumin (BSA).	Arginine	46-51	albumin	Homo sapiens	107-120
20213438-0	2010	Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn- and soybean meal-based diet.	Arginine	29-39	heat shock 70 kDa protein 6	Sus scrofa	94-115
20213438-6	2010	Real-time polymerase chain reaction and western blotting analyses revealed that both mRNA and protein levels for heat shock protein-70 (HSP70) were higher (P&lt;0.05) in the intestinal mucosae of Arg- or NCG-supplemented pigs than in the control group.	Arginine	196-199	heat shock 70 kDa protein 6	Sus scrofa	113-134
20484474-1	2010	CONTEXT: The GHRH plus arginine (GHRH+Arg) test is a promising alternative to the insulin tolerance test (ITT) for diagnosis of adult GH deficiency (AGHD).	Arginine	23-31	growth hormone releasing hormone	Homo sapiens	33-37
20579874-0	2010	BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.	Arginine	78-81	beta-secretase 1	Homo sapiens	0-6
20538734-2	2010	Although its metabolites bind at several positions in TP53, a mutation at codon 249 (AGG to AGT, arginine to serine, p.R249S) accounts for 90% of TP53 mutations in AFB(1)-related HCC.	Arginine	97-105	tumor protein p53	Homo sapiens	146-150
20505044-3	2010	Since the cationic amino acid l-arginine (l-Arg) is the substrate for NO production by NO synthases (NOS), we tested whether the transporters that mediate l-Arg import in cardiac muscle cells represent an intervention point in the regulation of NO synthesis.	Arginine	30-40	nitric oxide synthase 2	Homo sapiens	87-99
20505044-3	2010	Since the cationic amino acid l-arginine (l-Arg) is the substrate for NO production by NO synthases (NOS), we tested whether the transporters that mediate l-Arg import in cardiac muscle cells represent an intervention point in the regulation of NO synthesis.	Arginine	42-47	nitric oxide synthase 2	Homo sapiens	87-99
19851859-12	2010	All the HPV-positive cases were homozygous for arginine at TP53 codon 72, a genotype associated with HPV-related cancer risk, and the tumors showed p16(INK4A) immunostaining, a marker of HPV-associated cancers.	Arginine	47-55	tumor protein p53	Homo sapiens	59-63
20399881-10	2010	These data indicate that cCAT-2A is a low affinity, high velocity transporter for lysine and arginine and is the cCAT-2 isoform responsible for lysine and arginine transport in avian skeletal muscle.	Arginine	93-101	solute carrier family 7 member 2	Gallus gallus	25-31
20399881-10	2010	These data indicate that cCAT-2A is a low affinity, high velocity transporter for lysine and arginine and is the cCAT-2 isoform responsible for lysine and arginine transport in avian skeletal muscle.	Arginine	155-163	solute carrier family 7 member 2	Gallus gallus	25-31
20460421-11	2010	CONCLUSIONS: Our study has demonstrated that the acipimox-induced acute reduction of circulating FFA levels increases mean somatotropin response to GHRH+arginine in patients with essential obesity, whereas it has no effect in hypopituitary subjects.	Arginine	153-161	growth hormone 1	Homo sapiens	123-135
20484474-1	2010	CONTEXT: The GHRH plus arginine (GHRH+Arg) test is a promising alternative to the insulin tolerance test (ITT) for diagnosis of adult GH deficiency (AGHD).	Arginine	38-41	growth hormone releasing hormone	Homo sapiens	13-17
20484474-11	2010	The cutoff value leading to 95% specificity with the GHRH+Arg test was measured at about 3.67 microg/liter (sensitivity 79.0%).	Arginine	58-61	growth hormone releasing hormone	Homo sapiens	53-57
20484050-0	2010	Inhibition of thrombin formation by active site mutated (S360A) activated protein C. Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of factor Va (FVa) by cleavage at Arg(506) and Arg(306) and of factor VIIIa (FVIIIa) by cleavage at Arg(336) and Arg(562).	Arginine	212-215	coagulation factor II, thrombin	Homo sapiens	14-22
20116391-3	2010	We have recently shown that ERalpha is methylated specifically by the arginine methyltransferase PRMT1 at arginine 260 in the DNA-binding domain of the receptor.	Arginine	70-78	estrogen receptor 1	Homo sapiens	28-35
20430034-3	2010	The present study aims to characterize the role of PKC in the regulation of arginine transport and metabolism by human umbilical vein (HUVEC) and aortic (HAEC) endothelial cells.	Arginine	76-84	protein kinase C alpha	Homo sapiens	51-54
20430034-4	2010	The results obtained demonstrate that the activation of PKCalpha by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.	Arginine	131-139	protein kinase C alpha	Homo sapiens	56-64
20430034-5	2010	PKCalpha-dependent stimulation of arginine transport requires the activation of MEK/ERK1/2 cascade, which leads to the stimulation of AP-1 and to the consequent induction of CAT2 expression.	Arginine	34-42	protein kinase C alpha	Homo sapiens	0-8
20430034-5	2010	PKCalpha-dependent stimulation of arginine transport requires the activation of MEK/ERK1/2 cascade, which leads to the stimulation of AP-1 and to the consequent induction of CAT2 expression.	Arginine	34-42	mitogen-activated protein kinase kinase 7	Homo sapiens	80-83
20430034-5	2010	PKCalpha-dependent stimulation of arginine transport requires the activation of MEK/ERK1/2 cascade, which leads to the stimulation of AP-1 and to the consequent induction of CAT2 expression.	Arginine	34-42	mitogen-activated protein kinase 3	Homo sapiens	84-90
20430034-7	2010	It is concluded that the activation of PKCalpha stimulates arginine entry in human endothelial cells and shifts the metabolism of the cationic amino acid from NO synthesis to arginase-dependent production of ornithine and urea.	Arginine	59-67	protein kinase C alpha	Homo sapiens	39-47
20421238-6	2010	We identified a novel germ line variant of the 177 mutant (Pro to Arg; P177R) of p53 by genomic sequencing.	Arginine	66-69	tumor protein p53	Homo sapiens	81-84
20484050-0	2010	Inhibition of thrombin formation by active site mutated (S360A) activated protein C. Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of factor Va (FVa) by cleavage at Arg(506) and Arg(306) and of factor VIIIa (FVIIIa) by cleavage at Arg(336) and Arg(562).	Arginine	225-228	coagulation factor II, thrombin	Homo sapiens	14-22
20484050-0	2010	Inhibition of thrombin formation by active site mutated (S360A) activated protein C. Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of factor Va (FVa) by cleavage at Arg(506) and Arg(306) and of factor VIIIa (FVIIIa) by cleavage at Arg(336) and Arg(562).	Arginine	225-228	coagulation factor II, thrombin	Homo sapiens	14-22
20484050-0	2010	Inhibition of thrombin formation by active site mutated (S360A) activated protein C. Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of factor Va (FVa) by cleavage at Arg(506) and Arg(306) and of factor VIIIa (FVIIIa) by cleavage at Arg(336) and Arg(562).	Arginine	225-228	coagulation factor II, thrombin	Homo sapiens	14-22
20493979-5	2010	Through RT-PCR we have found increased expression for MED12 and decreased levels for MED30 after l-arginine treatment; Western blot analysis do not agree entirely with the RNA data in the identification of a putative protein product.	Arginine	97-107	mediator complex subunit 30	Homo sapiens	85-90
20480122-1	2010	Two kinds of arginine-rich amphiphilic lipopeptides with hydrophobic aliphatic tails (C(12)GR(8)GDS, LP1 and C(18)GR(8)GDS, LP2) were designed and synthesized as functional gene vectors.	Arginine	13-21	ribosomal protein lateral stalk subunit P2	Homo sapiens	124-127
20513808-5	2010	IDH1 and IDH2 mutations are remarkably specific to codons that encode conserved functionally important arginines in the active site of each enzyme.	Arginine	103-112	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
20493979-6	2010	Furthermore, we have analysed the three-dimensional nuclear positions of MED12 and MED30 genes in the presence of l-arginine treatment.	Arginine	114-124	mediator complex subunit 30	Homo sapiens	83-88
20477940-0	2010	The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1.	Arginine	19-27	solute carrier family 1 member 3	Homo sapiens	118-123
20398956-10	2010	CONCLUSION: L-arginine may have an anti-senescence effect via the PI3K/Akt pathway in HUVECs exposed to high glucose and it might be a therapeutic agent for diabetic vascular complications.	Arginine	12-22	AKT serine/threonine kinase 1	Homo sapiens	71-74
19965803-5	2010	The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP).	Arginine	19-27	C-reactive protein	Homo sapiens	244-262
19965803-5	2010	The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP).	Arginine	19-27	C-reactive protein	Homo sapiens	264-267
20380571-4	2010	The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively.	Arginine	19-22	tumor protein p53	Homo sapiens	63-66
20380571-4	2010	The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively.	Arginine	23-26	tumor protein p53	Homo sapiens	63-66
20380571-4	2010	The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes for P53 codon 72 were 51.7%, 41.4%, and 6.9% in patients and 42.6%, 47.3%, and 10.1% in controls, respectively.	Arginine	23-26	tumor protein p53	Homo sapiens	63-66
20173184-2	2010	The transfection capacity of LDL is based on apo B100, as arginine/lysine clusters, suggestive of nucleic acid-binding domains and nuclear localization signal sequences, are present throughout the molecule.	Arginine	58-66	apolipoprotein B	Homo sapiens	45-53
20173184-4	2010	Synthetic peptides representing two apo B100 regions with prominent Arg/Lys clusters were shown to bind DNA.	Arginine	68-71	apolipoprotein B	Homo sapiens	36-44
20477940-8	2010	Moving the arginine residue from TM8 to HP1 in EAAT1 results in a transporter that has significantly increased affinity for both glutamate and aspartate and is K(+) independent.	Arginine	11-19	solute carrier family 1 member 3	Homo sapiens	47-52
20498050-4	2010	K2P1-Lys274 is crucial: when mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1.	Arginine	45-48	SUMO specific peptidase 1	Homo sapiens	141-146
20421418-6	2010	In this current study, we identified the direct interaction between p62 and Keap1 and the residues required for the interaction have been mapped to 349-DPSTGE-354 in p62 and three arginines in the Kelch domain of Keap1.	Arginine	180-189	kelch like ECH associated protein 1	Homo sapiens	76-81
20421418-6	2010	In this current study, we identified the direct interaction between p62 and Keap1 and the residues required for the interaction have been mapped to 349-DPSTGE-354 in p62 and three arginines in the Kelch domain of Keap1.	Arginine	180-189	kelch like ECH associated protein 1	Homo sapiens	213-218
20071141-5	2010	RESULTS: The productions of vascular endothelial growth factor, basic fibroblast growth factor, prostaglandin E(2), and matrix metalloproteinase-2 were higher with Arg 100 and 1000 micromol/L than with Arg 0 and 50 micromol/L Arg, and this was consistent with the expression of CD51/CD61 by ECs.	Arginine	164-167	vascular endothelial growth factor A	Homo sapiens	28-62
23961079-1	2010	Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.	Arginine	58-68	nitric oxide synthase 3	Homo sapiens	72-105
23961079-1	2010	Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.	Arginine	58-68	nitric oxide synthase 3	Homo sapiens	107-111
23961079-1	2010	Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.	Arginine	58-68	nitric oxide synthase 3	Homo sapiens	128-132
20421307-7	2010	CaSRDelta898 exhibits maturation comparable with full-length CaSR, suggesting that the CaSR carboxyl terminus between residues Thr(868) and Arg(898) limits maturation.	Arginine	140-143	calcium sensing receptor	Homo sapiens	0-4
20471363-1	2010	A synthetic deca-peptide corresponding to the amino acid sequence Arg(54)-Trp(63) of human tissue-type plasminogen activator (t-PA) kringle 2 domain, named TKII-10, is produced and tested for its ability to inhibit endothelial cell proliferation, migration, tube formation in vitro, and angiogenesis in vivo.	Arginine	66-69	plasminogen activator, tissue type	Homo sapiens	91-124
20471363-1	2010	A synthetic deca-peptide corresponding to the amino acid sequence Arg(54)-Trp(63) of human tissue-type plasminogen activator (t-PA) kringle 2 domain, named TKII-10, is produced and tested for its ability to inhibit endothelial cell proliferation, migration, tube formation in vitro, and angiogenesis in vivo.	Arginine	66-69	plasminogen activator, tissue type	Homo sapiens	126-130
20385709-3	2010	BK-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) in mIMCD-3 cells was reduced by approximately 65% by synthetic peptides containing an Arg-Gly-Asp sequence, supporting roles for integrins in BK-induced signaling.	Arginine	168-171	mitogen-activated protein kinase 1	Mus musculus	30-75
20385709-3	2010	BK-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) in mIMCD-3 cells was reduced by approximately 65% by synthetic peptides containing an Arg-Gly-Asp sequence, supporting roles for integrins in BK-induced signaling.	Arginine	168-171	mitogen-activated protein kinase 1	Mus musculus	77-80
20575085-4	2010	The emergence of CBP in chromosomal domains is temporally coincident with the establishments of acetylated lysine 18 (AcH3/K18), lysine 23 (AcH3/K23) and dimethylated arginine 17 (dime-H3/R17) of histone H3 at meiotic stages from germinal vesicle breakdown (GVBD) to metaphase I (MI).	Arginine	167-175	CREB binding protein	Homo sapiens	17-20
20524691-1	2010	Apolipoprotein A-I Milano (apoA-I(Milano)) is a naturally occurring human mutation of wild-type apolipoprotein A-I (apoA-I(WT)) having cystine substituted for arginine(173).	Arginine	159-167	apolipoprotein A1	Homo sapiens	0-18
20524691-1	2010	Apolipoprotein A-I Milano (apoA-I(Milano)) is a naturally occurring human mutation of wild-type apolipoprotein A-I (apoA-I(WT)) having cystine substituted for arginine(173).	Arginine	159-167	apolipoprotein A1	Homo sapiens	27-41
20524691-1	2010	Apolipoprotein A-I Milano (apoA-I(Milano)) is a naturally occurring human mutation of wild-type apolipoprotein A-I (apoA-I(WT)) having cystine substituted for arginine(173).	Arginine	159-167	apolipoprotein A1	Homo sapiens	96-114
20524691-1	2010	Apolipoprotein A-I Milano (apoA-I(Milano)) is a naturally occurring human mutation of wild-type apolipoprotein A-I (apoA-I(WT)) having cystine substituted for arginine(173).	Arginine	159-167	apolipoprotein A1	Homo sapiens	116-126
20585552-2	2010	Arginine is also a common substrate for both inducible nitric oxide synthase (iNOS) and arginase.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	45-76
20585552-2	2010	Arginine is also a common substrate for both inducible nitric oxide synthase (iNOS) and arginase.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	78-82
20585552-5	2010	The competition between iNOS and arginase for arginine can thus contribute to the outcome of several parasitic and bacterial infections.	Arginine	46-54	nitric oxide synthase 2	Homo sapiens	24-28
20129751-6	2010	Zinc ions in the eluent promoted association of insulin to hexamers, whereas arginine overruled the effect of zinc ions and induced on-column dissociation of insulin to dimers and monomers.	Arginine	77-85	insulin	Homo sapiens	158-165
20642005-12	2004	A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11).	Arginine	74-77	proopiomelanocortin	Homo sapiens	25-34
20463604-4	2010	The experimental data show that activation of alternatively activated macrophages (aaMacs) within type-2 infiltrates by IL-4 or IL-13 can inhibit B16-F1 melanoma cell proliferation through a mechanism that is dependent on arginase-1 depletion of L-arginine within the tumor cell microenvironment.	Arginine	246-256	interleukin 13	Mus musculus	128-133
20642005-12	2004	A lactam bridge-cyclized alpha-MSH analog, GlyGlu-c[Lys-Nlc-Glu-His-d-Phe-Arg-Trp-Gly-Arg-Pro-Val-Asp] (GlyGlu-CycMSH), was conjugated with DOTA (11).	Arginine	86-89	proopiomelanocortin	Homo sapiens	25-34
20532206-1	2010	An elegantly simple and probably ancient molecular mechanism of allostery is described for the Escherichia coli arginine repressor ArgR, the master feedback regulator of transcription in L-arginine metabolism.	Arginine	187-197	arginine repressor	Escherichia coli	131-135
20215577-8	2010	L-arginine increased eNOS expression, phosphorylation of eNOS at Ser(1177), and association of eNOS and HSP90 without significantly altering HSP90 expression.	Arginine	0-10	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	104-109
20215577-9	2010	L-arginine may act through three pathways, providing a substrate for NO generation, preserving eNOS expression/phosphorylation, and maintaining the association of eNOS and HSP90, which allows restoration of eNOS activity and coupling activity, to maintain the balance between NO and O(2)(*-) and delay the development of PH.	Arginine	0-10	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	172-177
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	195-198	tumor protein p53	Homo sapiens	23-26
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	195-198	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	195-198	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	199-202	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	199-202	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	199-202	tumor protein p53	Homo sapiens	175-178
19948747-4	2010	Since mutations in the p53 gene are present in approximately 40% of all human lung cancers and are more common in smokers than in nonsmokers, we aimed to detect the status of p53 at codon 72 for Arg/Arg or Arg/Pro or Pro/Pro allele polymorphism and p53 codon 249 mutation in smokers and nonsmokers of South India.	Arginine	199-202	tumor protein p53	Homo sapiens	175-178
20644702-11	2010	Aside from the insulin tolerance test, the GHRH-arginine test has become well established.	Arginine	48-56	growth hormone releasing hormone	Homo sapiens	43-47
19768790-4	2010	The presence of a small molecule that inhibits autophosphorylation of the FGF2 receptor blocked the effects of FGF2 on hMSC viability in PEG hydrogels, both in the presence and absence of the Arg-Gly-Asp-Ser-Pro (RGDSP) ligand.	Arginine	192-195	fibroblast growth factor 2	Homo sapiens	74-78
20156847-5	2010	Curiously, 14 of 15 HypoPP mutations are at arginines in S4 voltage sensors, and recent observations show that these substitutions support an alternative pathway for ion conduction, the gating pore, that may be the source of the aberrant depolarization during an attack of paralysis.	Arginine	44-53	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	20-26
19447018-9	2010	Results showed that the MMP-2, MMP-9 and VEGF receptor levels in tumors were significantly lower, whereas tumor NO levels and spleen natural killer (NK) cell activities were higher in the Arg group than in the control group.	Arginine	188-191	vascular endothelial growth factor A	Homo sapiens	41-45
20308061-4	2010	TGF-beta1 binding is predicted to alter LAP conformation, exposing ionic residues (Arg(45), Arg(50), Lys(56), and Arg(58)) on the other side of the alpha-helix, which form the binding site for latent TGF-beta-binding proteins.	Arginine	83-86	transforming growth factor beta 1	Homo sapiens	0-9
20512840-3	2010	Actually, polymorphic variants Arg and Pro were found to have different properties of regulation of TP53-dependent DNA repair target genes, that can effect various levels of chromosome aberrations in cancer patients with these genotypes.	Arginine	31-34	tumor protein p53	Homo sapiens	100-104
20512840-5	2010	It was shown that the Arg variant of TP53 gene is associated with high frequency of AC and chromatid breaks.	Arginine	22-25	tumor protein p53	Homo sapiens	37-41
20123736-4	2010	TRAP150 contains an arginine/serine-rich domain and has sequence similarity with the cell death-promoting transcriptional repressor BCLAF1.	Arginine	20-28	thyroid hormone receptor associated protein 3	Homo sapiens	0-7
20308061-4	2010	TGF-beta1 binding is predicted to alter LAP conformation, exposing ionic residues (Arg(45), Arg(50), Lys(56), and Arg(58)) on the other side of the alpha-helix, which form the binding site for latent TGF-beta-binding proteins.	Arginine	92-95	transforming growth factor beta 1	Homo sapiens	0-9
20308061-4	2010	TGF-beta1 binding is predicted to alter LAP conformation, exposing ionic residues (Arg(45), Arg(50), Lys(56), and Arg(58)) on the other side of the alpha-helix, which form the binding site for latent TGF-beta-binding proteins.	Arginine	92-95	transforming growth factor beta 1	Homo sapiens	0-9
20642000-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
20143318-6	2010	Substrate channeling between the enzymes was observed when NSE with its active regions Leu(11)-Asn(16), Arg(49)-Lys(59), and Gly(155)-Ala(158) covered the Ser(14)-Leu(30) loop of dPGM-B.	Arginine	104-107	enolase 2	Homo sapiens	59-62
20155311-5	2010	The analysis of deletions of amino acid residues 1-11, 1-22, and 22-33 of CP demonstrated that there were two separate nuclear localization signals (NLS) within the N-terminus--a strong NLS1 in the arginine-rich region (residues 22-33) and a weaker NLS2 within residues 1-22.	Arginine	198-206	major facilitator superfamily domain containing 2A	Homo sapiens	186-190
20225330-8	2010	Furthermore, stratification analyses showed that the risk of SPM associated with p53 variant genotypes (Arg/Pro + Pro/Pro) was more pronounced in several subgroups.	Arginine	104-107	tumor protein p53	Homo sapiens	81-84
20395852-0	2010	Arginine-enriched total parenteral nutrition improves survival in peritonitis by normalizing NFkappaB activation in peritoneal resident and exudative leukocytes.	Arginine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-101
20114041-1	2010	BACKGROUND: Endothelium derived nitric oxide is formed from l-arginine by endothelial nitric oxide synthase encoded by the nitric oxide synthase 3 (NOS3) gene.	Arginine	60-70	nitric oxide synthase 3	Homo sapiens	123-146
20114041-1	2010	BACKGROUND: Endothelium derived nitric oxide is formed from l-arginine by endothelial nitric oxide synthase encoded by the nitric oxide synthase 3 (NOS3) gene.	Arginine	60-70	nitric oxide synthase 3	Homo sapiens	148-152
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Arginine	93-101	tumor protein p53	Homo sapiens	12-15
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Arginine	93-101	tumor protein p53	Homo sapiens	140-143
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Arginine	103-106	tumor protein p53	Homo sapiens	12-15
20658010-1	2010	UNLABELLED: p53 tumoral suppressor gene harbors a functional polymorphism which codes either arginine (Arg) or proline (Pro) in the protein p53 of codon 72.	Arginine	103-106	tumor protein p53	Homo sapiens	140-143
20395852-8	2010	RESULTS: Experiment 1: Intranuclear NFkappaB levels in the ARG-TPN and chow groups increased dose-dependently after LPS stimulation, while the level in the STD-TPN group was unchanged.Experiment 2: Intranuclear NFkappaB level was significantly higher at 2 hours in the chow than in the STD-TPN group, whereas in the ARG-TPN mice the level was midway between those of the chow and STD-TPN groups.	Arginine	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-44
20395852-2	2010	We hypothesized that arginine (ARG)-enriched parenteral nutrition would normalize NFkappaB activation in peritoneal leukocytes, thereby improving the survival of peritonitis models.	Arginine	21-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-90
20395852-10	2010	TNFalpha was significantly higher in the ARG-TPN group than in the STD-TPN group, but the IL-10 level showed no recovery.Experiment 3: Survival times were significantly reduced in the STD-TPN as compared with the chow group, though ARG-TPN improved survival.	Arginine	41-44	tumor necrosis factor	Mus musculus	0-8
20395852-11	2010	CONCLUSION: ARG-enriched TPN is a surrogate for enteral feeding which maintains peritoneal defense by preserving NFkappaB activation in peritoneal resident and exudative leukocytes.	Arginine	12-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-121
20395852-2	2010	We hypothesized that arginine (ARG)-enriched parenteral nutrition would normalize NFkappaB activation in peritoneal leukocytes, thereby improving the survival of peritonitis models.	Arginine	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-90
20218897-5	2010	Two missense mutations in UTF1 are reported: rs11599284, which results in a glycine to an arginine change at amino acid 73, and rs4480453, resulting in a leucine to methionine change at amino acid 275.	Arginine	90-98	undifferentiated embryonic cell transcription factor 1	Homo sapiens	26-30
20138041-8	2010	Bioactive GIP was secreted from mouse and human islets after arginine stimulation.	Arginine	61-69	gastric inhibitory polypeptide	Mus musculus	10-13
20216569-2	2010	It has been shown that GH release can be promoted by administration of various amino acids (AAs), such as arginine and lysine, that are present in soy protein.	Arginine	106-114	growth hormone 1	Homo sapiens	23-25
20216569-12	2010	Arginine may be the responsible AA in the GH-promoting effect of gelatin, although each protein may have its own specific AA-spectrum involved in the stimulation of the somatotropic axis.	Arginine	0-8	growth hormone 1	Homo sapiens	42-44
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Arginine	67-75	tumor protein p53	Homo sapiens	40-43
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Arginine	67-75	tumor protein p53	Homo sapiens	98-101
20207828-6	2010	In addition, GLP-1 decreased the arginine-stimulated glucagon release (incremental AUC of 103 +/- 21 and 137 +/- 16 pmol/liter x min, with GLP-1 and saline, respectively, P &lt; 0.05).	Arginine	33-41	glucagon	Homo sapiens	13-18
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Arginine	107-115	tumor protein p53	Homo sapiens	40-43
20019240-0	2010	Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.	Arginine	107-115	tumor protein p53	Homo sapiens	98-101
20019240-4	2010	The largest difference between p53-arginine and p53-proline was found with the PERP gene involved in cell-cell adhesion and apoptosis.	Arginine	35-43	tumor protein p53	Homo sapiens	31-34
20207828-6	2010	In addition, GLP-1 decreased the arginine-stimulated glucagon release (incremental AUC of 103 +/- 21 and 137 +/- 16 pmol/liter x min, with GLP-1 and saline, respectively, P &lt; 0.05).	Arginine	33-41	glucagon	Homo sapiens	139-144
20335448-10	2010	CONCLUSIONS: Dexamethasone treatment is effective in controlling the premature pubarche, hypoglycemia, hypertension, and hypokalemia in this child case, wherein arginine 714 plays a key role in the proper formation of the ligand-binding pocket and the AF-2 surface of the GR alpha LBD.	Arginine	161-169	nuclear receptor subfamily 3 group C member 1	Homo sapiens	272-274
20207828-7	2010	CONCLUSIONS: In type 1 diabetic patients without endogenous insulin secretion, GLP-1 decreases the glucagon secretion as well as the arginine-induced glucagon response during hyperglycemia.	Arginine	133-141	glucagon	Homo sapiens	79-84
20346714-1	2010	OBJECTIVES: It is well established that fibrous dysplasia (FD) is caused by mutations of the Arg(201) codon of the GNAS gene.	Arginine	93-96	GNAS complex locus	Homo sapiens	115-119
19685013-4	2010	Here, we employed a mutant Abeta (Abeta H13R) in which a histidine residue was replaced by arginine.	Arginine	91-99	amyloid beta precursor protein	Homo sapiens	27-32
19685013-4	2010	Here, we employed a mutant Abeta (Abeta H13R) in which a histidine residue was replaced by arginine.	Arginine	91-99	amyloid beta precursor protein	Homo sapiens	34-39
20614517-3	2010	Impaired L-arginine metabolism was related to the higher activities of protein kinase C (PKC), phosphodiesterase (PDE), and 5-lipoxygenase (5-LO) along with decreased cyclooxygenase activity and drastic protein kinase A (PKA) inhibition.	Arginine	9-19	arachidonate 5-lipoxygenase	Homo sapiens	124-138
20159941-1	2010	Substitution of arginine-137 of the vasopressin type 2 receptor (V2R) for histidine (R137H-V2R) leads to nephrogenic diabetes insipidus (NDI), whereas substitution of the same residue to cysteine or leucine (R137C/L-V2R) causes the nephrogenic syndrome of inappropriate antidiuresis (NSIAD).	Arginine	16-24	arginine vasopressin receptor 2	Homo sapiens	36-68
20186136-3	2010	In 16 morbid obese subjects (9 with T2DM and 7 with normal fasting glucose (NFG)), we measured insulin secretion after glucose-dependent arginine stimulation test and after intravenous glucose tolerance test (IVGTT) before and 1 month after BPD.	Arginine	137-145	insulin	Homo sapiens	95-102
20186136-6	2010	A reduction of insulin response to arginine was observed in NFG, whereas opposite was found in T2DM.	Arginine	35-43	insulin	Homo sapiens	15-22
20186136-7	2010	In particular, acute insulin response to arginine at basal glucose concentrations (AIR(basal)) was reduced but insulin response at 14 mmol/l of plasma glucose (AIR(14)) was increased.	Arginine	41-49	insulin	Homo sapiens	21-28
20346714-3	2010	In this study, we examined COD and COF for mutations at the Arg(201) codon of the GNAS gene.	Arginine	60-63	GNAS complex locus	Homo sapiens	82-86
20346714-5	2010	We used 2 PCR-RFLP methods to detect mutations at the Arg(201) codon of the GNAS gene.	Arginine	54-57	GNAS complex locus	Homo sapiens	76-80
20188776-1	2010	The anti-hypertensive peptide Arg-Ile-Tyr, which was isolated based on its inhibitory activity (IC(50)=28microM) for angiotensin I-converting enzyme (ACE) from the subtilisin digest of rapeseed protein, exhibited vasorelaxing activity (EC(50)=5.1microM) in an endothelium-dependent manner in the mesenteric artery of spontaneously hypertensive rats (SHRs).	Arginine	30-33	angiotensin I converting enzyme	Rattus norvegicus	117-148
20188776-1	2010	The anti-hypertensive peptide Arg-Ile-Tyr, which was isolated based on its inhibitory activity (IC(50)=28microM) for angiotensin I-converting enzyme (ACE) from the subtilisin digest of rapeseed protein, exhibited vasorelaxing activity (EC(50)=5.1microM) in an endothelium-dependent manner in the mesenteric artery of spontaneously hypertensive rats (SHRs).	Arginine	30-33	angiotensin I converting enzyme	Rattus norvegicus	150-153
20346714-6	2010	RESULTS: Mutations at the Arg(201) codon of the GNAS gene were not present in any of the COD and COF examined.	Arginine	26-29	GNAS complex locus	Homo sapiens	48-52
20197274-6	2010	In this in situ based NBCe1-A topology, residues mutated in pRTA (pRTA residues) are assigned as: Ser(427), TM1; Thr(485) and Gly(486), TM3; Arg(510) and Leu(522), TM4; Ala(799), TM10; and Arg(881), TM12.	Arginine	141-144	solute carrier family 4 member 4	Homo sapiens	22-29
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Arginine	65-73	growth hormone 1	Homo sapiens	108-110
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Arginine	65-73	insulin like growth factor 1	Homo sapiens	111-116
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Arginine	75-78	growth hormone 1	Homo sapiens	108-110
19758483-2	2010	The intake of protein (PROT) as well as the specific amino acids arginine (ARG) and lysine (LYS) stimulates GH/IGF-I secretion.	Arginine	75-78	insulin like growth factor 1	Homo sapiens	111-116
20568399-6	2010	One of NFKBIL1 gene coding sequence polymorphisms is a non-synonymous thymine-cytosine substitution at position 738 (exon 4) resulting in cysteine-arginine substitution at position 224 of encoded protein.	Arginine	147-155	NFKB inhibitor like 1	Homo sapiens	7-14
20197274-6	2010	In this in situ based NBCe1-A topology, residues mutated in pRTA (pRTA residues) are assigned as: Ser(427), TM1; Thr(485) and Gly(486), TM3; Arg(510) and Leu(522), TM4; Ala(799), TM10; and Arg(881), TM12.	Arginine	189-192	solute carrier family 4 member 4	Homo sapiens	22-29
20159986-4	2010	We show that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg(158) and Arg(160) residues.	Arginine	77-80	protein arginine methyltransferase 5	Homo sapiens	13-18
20159986-4	2010	We show that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg(158) and Arg(160) residues.	Arginine	90-93	protein arginine methyltransferase 5	Homo sapiens	13-18
20156196-4	2010	Two arginine residues of endostatin, Arg27 and Arg139, are crucial for its binding to TG-2.	Arginine	4-12	transglutaminase 2	Homo sapiens	86-90
20398418-6	2010	An increased risk was also associated with the TP53 Pro/Pro genotype (OR = 2.22, 95% CI = 1.58-3.10) compared to the Arg/Arg genotype.	Arginine	117-120	tumor protein p53	Homo sapiens	47-51
20398418-6	2010	An increased risk was also associated with the TP53 Pro/Pro genotype (OR = 2.22, 95% CI = 1.58-3.10) compared to the Arg/Arg genotype.	Arginine	121-124	tumor protein p53	Homo sapiens	47-51
20659168-1	2010	The Escherichia coli arginine repressor (ArgR) is an L-arginine-dependent DNA-binding protein that controls the expression of the arginine biosynthetic genes and is required as an accessory factor for Xer site-specific recombination at cer and related recombination sites in plasmids.	Arginine	21-29	arginine repressor	Escherichia coli	41-45
20231378-3	2010	We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1.	Arginine	25-33	CD79a molecule	Homo sapiens	62-69
20231378-5	2010	Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.	Arginine	14-22	CD79a molecule	Homo sapiens	6-13
20167924-4	2010	The insertion allele disrupted binding of metal-regulatory transcription factor 1, which resulted in significant reduction of in vitro DDAH1 transcriptional activity and in vivo DDAH1 mRNA level, and in turn, increased plasma ADMA level and the ratio of ADMA to L-arginine.	Arginine	262-272	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	135-140
20167924-4	2010	The insertion allele disrupted binding of metal-regulatory transcription factor 1, which resulted in significant reduction of in vitro DDAH1 transcriptional activity and in vivo DDAH1 mRNA level, and in turn, increased plasma ADMA level and the ratio of ADMA to L-arginine.	Arginine	262-272	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	178-183
19669080-8	2010	Consistent with the data on cell growth and protein turnover, addition of 100 or 350 microM Arg to culture medium increased relative protein levels for phosphorylated mTOR and phosphorylated ribosomal protein S6 kinase-1, while reducing the relative levels of TLR4 and phosphorylated levels of nuclear factor-kappaB in LPS-treated IPEC-1 cells.	Arginine	92-95	mechanistic target of rapamycin kinase	Sus scrofa	167-171
19669080-9	2010	These results demonstrate a protective effect of Arg against LPS-induced enterocyte damage through mechanisms involving mTOR and TLR4 signaling pathways, as well as intracellular protein turnover.	Arginine	49-52	mechanistic target of rapamycin kinase	Sus scrofa	120-124
20214681-6	2010	When ZF-RNase-3 is added to E. coli cultures, it is cleaved at a specific Arg-Arg peptide bond, thus engendering two peptide fragments.	Arginine	74-77	ribonuclease like 3	Danio rerio	5-15
20214681-6	2010	When ZF-RNase-3 is added to E. coli cultures, it is cleaved at a specific Arg-Arg peptide bond, thus engendering two peptide fragments.	Arginine	78-81	ribonuclease like 3	Danio rerio	5-15
20646482-1	2010	OBJECTIVE: To explore the therapy effects of (arginine-glycine-aspartic, RGD)(3)-truncated tissue factor (tTF) fusion protein on colorectal carcinoma in mice.	Arginine	46-54	coagulation factor III	Mus musculus	91-104
19484400-0	2010	Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity.	Arginine	133-141	coagulation factor II thrombin receptor	Homo sapiens	59-63
19484400-0	2010	Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity.	Arginine	133-141	coagulation factor II, thrombin	Homo sapiens	64-72
20068133-4	2010	RESULTS: Advanced glycation end product (AGE) content of apolipoprotein B100 of LDL from type 2 diabetic patients was higher than from healthy subjects: arginine-derived AGE, 15.8 vs. 5.3 mol% (P &lt; 0.001); and lysine-derived AGE, 2.5 vs. 1.5 mol% (P &lt; 0.05).	Arginine	153-161	apolipoprotein B	Homo sapiens	57-76
20659168-4	2010	A truncated ArgR containing a stop codon at residue 150 displayed the same phenotype as the protein with the five amino acid insertion, and both mutants displayed sequence-specific DNA-binding activity that was L-arginine dependent.	Arginine	211-221	arginine repressor	Escherichia coli	12-16
19810096-5	2010	In the Arg/Arg variant, apoptotic cells induced by 5-FU treatment in patients without inactive p53 mutation were more markedly increased than those in patients with inactive p53 mutation (p = 0.037).	Arginine	7-10	tumor protein p53	Homo sapiens	95-98
20144956-7	2010	MPO activity and TNF-alpha expression in lung were upregulated in the ANP rats and further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively.	Arginine	121-126	tumor necrosis factor	Rattus norvegicus	17-26
19810096-4	2010	5-FU sensitivity of tumor cells without inactive p53 mutation in the arginine/arginine (Arg/Arg) variant was significantly higher than that of tumor cells with or without inactive p53 mutation in other variants (p = 0.022), whereas the 5-FU sensitivity of tumor cells with inactive p53 mutation in the Arg/Arg variant was significantly lower than that of tumor cells with or without inactive p53 mutation in other variants (p = 0.002).	Arginine	69-77	tumor protein p53	Homo sapiens	49-52
19810096-5	2010	In the Arg/Arg variant, apoptotic cells induced by 5-FU treatment in patients without inactive p53 mutation were more markedly increased than those in patients with inactive p53 mutation (p = 0.037).	Arginine	7-10	tumor protein p53	Homo sapiens	174-177
19810096-5	2010	In the Arg/Arg variant, apoptotic cells induced by 5-FU treatment in patients without inactive p53 mutation were more markedly increased than those in patients with inactive p53 mutation (p = 0.037).	Arginine	11-14	tumor protein p53	Homo sapiens	95-98
19810096-5	2010	In the Arg/Arg variant, apoptotic cells induced by 5-FU treatment in patients without inactive p53 mutation were more markedly increased than those in patients with inactive p53 mutation (p = 0.037).	Arginine	11-14	tumor protein p53	Homo sapiens	174-177
20164294-7	2010	MAIN OUTCOME MEASURES: We measured the GH response to GHRH-ARG in aromatase-deficient men (at baseline and during estrogen treatment) and in normal subjects.	Arginine	59-62	growth hormone releasing hormone	Homo sapiens	54-58
20125033-0	2010	L-arginine enhances nitrative stress and exacerbates tumor necrosis factor-alpha toxicity to human endothelial cells in culture: prevention by propofol.	Arginine	0-10	tumor necrosis factor	Homo sapiens	53-80
20125033-4	2010	We postulated that L-arginine may exacerbate TNF-induced endothelial cell apoptosis by enhancing peroxynitrite-mediated nitrative stress.	Arginine	19-29	tumor necrosis factor	Homo sapiens	45-48
20125033-8	2010	L-arginine did not enhance TNF-induced increases of superoxide and peroxynitrite production but further increased TNF-induced increase of nitrotyrosine production and exacerbated TNF-mediated cell apoptosis.	Arginine	0-10	tumor necrosis factor	Homo sapiens	114-117
20125033-8	2010	L-arginine did not enhance TNF-induced increases of superoxide and peroxynitrite production but further increased TNF-induced increase of nitrotyrosine production and exacerbated TNF-mediated cell apoptosis.	Arginine	0-10	tumor necrosis factor	Homo sapiens	114-117
20170338-6	2010	ACE inhibitory peptide was identified as being seven amino acid residues of Ala-Gln-Gly-Glu-Arg-His-Arg by N-terminal amino acid sequence analysis.	Arginine	92-95	angiotensin I converting enzyme	Homo sapiens	0-3
20300016-1	2010	This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes.	Arginine	85-88	insulin	Homo sapiens	202-209
20300016-6	2010	Significant increases (p &lt; 0.05) were observed in both GH and IGF-1 serum levels after arg and orn supplementation at both time points, whereas a significant decrease was seen in IGFBP-3 protein during the recovery period.	Arginine	90-93	insulin like growth factor 1	Homo sapiens	65-70
20300016-7	2010	Because there was no between-group difference in the remaining hormone levels, it appears that the GH/IGF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation.	Arginine	214-217	insulin like growth factor 1	Homo sapiens	102-107
22477579-7	2010	Cysteine, glutathione (a tripeptide), glutamate and arginine attenuate and prevent alterations that cause hypertension including insulin resistance, decreased nitric oxide bioavailability, altered renin angiotensin system function, increased oxidative stress and formation of advanced glycation end products.	Arginine	52-60	renin	Homo sapiens	197-202
20125033-11	2010	Thus, under pathological conditions associated with increased TNF production, L-arginine supplementation may further exacerbate TNF cellular toxicity by enhancing nitrative stress.	Arginine	78-88	tumor necrosis factor	Homo sapiens	62-65
20125033-11	2010	Thus, under pathological conditions associated with increased TNF production, L-arginine supplementation may further exacerbate TNF cellular toxicity by enhancing nitrative stress.	Arginine	78-88	tumor necrosis factor	Homo sapiens	128-131
20300016-0	2010	Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.	Arginine	0-8	insulin	Homo sapiens	68-75
20300016-1	2010	This placebo-controlled double-blind study was designed to investigate the effect of arginine and ornithine (arg and orn) supplementation during 3-week heavy-resistance training on serum growth hormone/insulin-like growth factor-1/insulin-like growth factor-binding protein 3 (GH/IGF-1/IGFBP-3), testosterone, cortisol, and insulin levels in experienced strength-trained athletes.	Arginine	85-93	insulin	Homo sapiens	202-209
20080302-3	2010	Our objective was to pharmacologically characterize the BBB permeability induced by the synthetic biostable BK-B2R analogue [Phe(8)psi(CH(2)NH)Arg(9)]-BK (R523) in F98 glioma-implanted Fischer rats.	Arginine	143-146	bradykinin receptor B2	Rattus norvegicus	111-114
20045558-2	2010	After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two distinct G protein-coupled receptors (GPCR), called B2 (B2R) or B1 (B1R).	Arginine	78-81	bradykinin receptor B1	Homo sapiens	171-173
20045558-2	2010	After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two distinct G protein-coupled receptors (GPCR), called B2 (B2R) or B1 (B1R).	Arginine	78-81	bradykinin receptor B1	Homo sapiens	175-178
20116077-6	2010	Based on the structure of these proteins and other enzymes from the Caricaceae family whose structures have been resolved, it is proposed that Arg(180) located in the cleft at the active site in CMS2MS2 is responsible for its resistance to cystatin.	Arginine	143-146	cystatin C	Gallus gallus	240-248
20185342-7	2010	CONCLUSIONS: The eNOS T-786C polymorphism affecting NO production is associated with NICO, may contribute to the pathogenesis of NICO, and may open therapeutic medical approaches to treatment of NICO through provision of L-arginine, the amino-acid precursor of NO.	Arginine	221-231	nitric oxide synthase 3	Homo sapiens	17-21
20075158-0	2010	Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.	Arginine	20-23	von Willebrand factor	Homo sapiens	115-136
20172963-3	2010	We investigated the biological role of the basic amino acid carrier Basic Amino Acid Carrier2 (BAC2) from Arabidopsis that is structurally and functionally similar to ARG11, a yeast ornithine and arginine carrier, and to Arabidopsis BAC1.	Arginine	196-204	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	68-93
20172963-3	2010	We investigated the biological role of the basic amino acid carrier Basic Amino Acid Carrier2 (BAC2) from Arabidopsis that is structurally and functionally similar to ARG11, a yeast ornithine and arginine carrier, and to Arabidopsis BAC1.	Arginine	196-204	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	95-99
20172963-4	2010	By studying the expression of BAC2 and the consequences of its mutation in Arabidopsis, we showed that BAC2 is a genuine mitochondrial protein and that Arabidopsis requires expression of the BAC2 gene in order to use arginine.	Arginine	217-225	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	30-34
19951310-9	2010	CONCLUSION: The low prevalence Rh antigen, Be(a), is associated with a single nucleotide change in exon 5 of RHCE*ce; that of 662C&gt;G and this change is predicted to alter proline at amino acid position 221 of Rhce to arginine.	Arginine	220-228	Rh blood group CcEe antigens	Homo sapiens	109-113
20071328-3	2010	Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties.	Arginine	93-96	coagulation factor II, thrombin	Homo sapiens	24-32
20734577-4	2010	PON1 activity is under genetic control and its molecular basis is a polymorphism in the PON1 gene that shows two common isoforms: the wild Q form (192 Gln) with high ability to protect LDL from lipid peroxidation in vitro, and the mutated R (Arg) form with lower ability.	Arginine	242-245	paraoxonase 1	Homo sapiens	0-4
20734577-4	2010	PON1 activity is under genetic control and its molecular basis is a polymorphism in the PON1 gene that shows two common isoforms: the wild Q form (192 Gln) with high ability to protect LDL from lipid peroxidation in vitro, and the mutated R (Arg) form with lower ability.	Arginine	242-245	paraoxonase 1	Homo sapiens	88-92
20155951-6	2010	A cluster of histidine and proline residues (His98-Pro99-His100-Pro101-His102) in kappa-casein binds to the C-terminal domain of the protein, where a neighboring conserved arginine residue (Arg97) is found to be important for stabilizing the binding pose.	Arginine	172-180	casein kappa	Bos taurus	82-94
19673702-6	2010	Induction of iNOS expression in RAW264.7 cells with LPS (lipopolysaccharide; 1 microg/ml) causes a significant increase in PMA-induced chemiluminescence, which could be enhanced by the NOS substrate, L-arginine, and could be abolished by the NOS inhibitor, L-NNA (NG-nitro-L-arginine).	Arginine	200-210	nitric oxide synthase 2, inducible	Mus musculus	13-17
20075158-0	2010	Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.	Arginine	30-33	von Willebrand factor	Homo sapiens	115-136
20075158-4	2010	A deletion of all these 6 amino acid residues (ie, Arg(659)-Glu(664)) from the ADAMTS13 spacer domain resulted in dramatically reduced proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid shear stress, as well as ultralarge VWF on endothelial cells.	Arginine	51-54	von Willebrand factor	Homo sapiens	163-166
20075158-4	2010	A deletion of all these 6 amino acid residues (ie, Arg(659)-Glu(664)) from the ADAMTS13 spacer domain resulted in dramatically reduced proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid shear stress, as well as ultralarge VWF on endothelial cells.	Arginine	51-54	von Willebrand factor	Homo sapiens	203-206
20075158-4	2010	A deletion of all these 6 amino acid residues (ie, Arg(659)-Glu(664)) from the ADAMTS13 spacer domain resulted in dramatically reduced proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid shear stress, as well as ultralarge VWF on endothelial cells.	Arginine	51-54	von Willebrand factor	Homo sapiens	203-206
20221403-7	2010	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PXXXPR) found in several CIN85 effectors.	Arginine	73-81	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
20221403-7	2010	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PXXXPR) found in several CIN85 effectors.	Arginine	73-81	SH3 domain containing kinase binding protein 1	Homo sapiens	114-119
20025859-4	2010	RESULTS: A substitution of C&gt;T in exon 12 was found in both subjects, changing the codon CGA for arginine (aa509) to TGA, a stop codon.	Arginine	100-108	chromogranin A	Homo sapiens	92-95
20022955-4	2010	In a promoter-specific context, inhibition of H3R17 methylation represses expression of p21, a p53-responsive gene, thus implicating a possible role for H3 Arg-17 methylation in tumor suppressor function.	Arginine	156-159	tumor protein p53	Homo sapiens	95-98
19283444-3	2010	The reported results demonstrate that the functionalization of L-ornithine side-chain with a neutral sulfamoyl group can generate an arginine bioisostere which can be used for the synthesis of prototypes of a new class of human thrombin inhibitors.	Arginine	133-141	coagulation factor II, thrombin	Homo sapiens	228-236
19951943-1	2010	Nitric-oxide synthases (NOS) are highly regulated heme-thiolate enzymes that catalyze two oxidation reactions that sequentially convert the substrate L-Arg first to N(omega)-hydroxyl-L-arginine and then to L-citrulline and nitric oxide.	Arginine	150-155	nitric oxide synthase 2	Homo sapiens	0-22
20363991-6	2010	RESULTS: There were statistically significant differences in the distribution of CDKN1A Ser/Arg genotypes and allele frequencies between colorectal cancer patients and healthy controls (p=0.040 and p=0.01, respectively).	Arginine	92-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-87
20193843-9	2010	Moreover, we identified mutation of TP53 gene in codon 273; triplet CGT coding Arg was changed to CAG coding His.	Arginine	79-82	tumor protein p53	Homo sapiens	36-40
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Arginine	58-66	tumor protein p53	Homo sapiens	28-32
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Arginine	58-66	tumor protein p53	Homo sapiens	98-101
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Arginine	68-71	tumor protein p53	Homo sapiens	28-32
20193851-1	2010	Polymorphism at codon 72 of TP53, resulting in either the arginine (Arg) or proline (Pro) form of p53 (R72P), has been associated with the susceptibility to different cancers.	Arginine	68-71	tumor protein p53	Homo sapiens	98-101
20485928-1	2010	OBJECTIVE: The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries.	Arginine	122-125	lactotransferrin	Homo sapiens	63-79
20153031-3	2010	METHODS: Different doses of L-arginine were administered to ovalbumin-sensitized and challenged mice.	Arginine	28-38	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	60-69
20485928-5	2010	The LTF A/G (Lys/Arg) polymorphism had been previously reported as located in exon 1.	Arginine	17-20	lactotransferrin	Homo sapiens	4-7
20097708-5	2010	INTERVENTION AND MAIN OUTCOME MEASURES: All participants underwent glucose-potentiated arginine testing where acute insulin responses to arginine (5 g) were determined under fasting (AIR(arg)), 230 mg/dl (AIR(pot)), and 340 mg/dl (AIR(max)) clamp conditions, and AIR(max) gives the beta-cell secretory capacity.	Arginine	137-145	insulin	Homo sapiens	116-123
20053922-3	2010	L-arginine plays a role in numerous physiological processes including nitrogen detoxification, immunocompetence, growth hormone (GH) secretion, and insulin secretion.	Arginine	0-10	growth hormone 1	Homo sapiens	113-127
20053922-3	2010	L-arginine plays a role in numerous physiological processes including nitrogen detoxification, immunocompetence, growth hormone (GH) secretion, and insulin secretion.	Arginine	0-10	growth hormone 1	Homo sapiens	129-131
19917673-0	2010	Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma.	Arginine	13-21	G protein pathway suppressor 2	Homo sapiens	70-75
19917673-7	2010	The results show for the first time that GPS-2 is differentially methylated at a site that lacks known methylation motifs and that the methylation state is detected by the immune system.-Jarmalavicius, S., Trefzer, U., Walden, P. Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma.	Arginine	243-251	G protein pathway suppressor 2	Homo sapiens	41-46
20097708-7	2010	RESULTS: Insulin responses were significantly lower than normal in the islet group for AIR(arg) (P &lt; 0.05), AIR(pot) (P &lt; 0.01), and AIR(max) (P &lt; 0.01), whereas responses in the pancreas-kidney and kidney transplant groups were not different than in the kidney donor group.	Arginine	91-94	insulin	Homo sapiens	9-16
20097867-4	2010	We have reported that macrophages can kill H. pylori in vitro by an NO-dependent mechanism, but supraphysiologic levels of the iNOS substrate l-arginine are required.	Arginine	142-152	nitric oxide synthase 2, inducible	Mus musculus	127-131
19939821-3	2010	Paraoxonase 1 polymorphism 192Gln/Arg influenced the risk of premature MI (P = .0054).	Arginine	34-37	paraoxonase 1	Homo sapiens	0-13
20110129-1	2010	Nitric oxide synthase (NOS) catalyzes the NADPH- and O(2)-dependent oxidation of l-arginine (l-Arg) to nitric oxide (NO) and citrulline via an N(G)-hydroxy-l-arginine (NHA) intermediate.	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	0-21
20110129-1	2010	Nitric oxide synthase (NOS) catalyzes the NADPH- and O(2)-dependent oxidation of l-arginine (l-Arg) to nitric oxide (NO) and citrulline via an N(G)-hydroxy-l-arginine (NHA) intermediate.	Arginine	93-98	nitric oxide synthase 2	Homo sapiens	0-21
20167108-3	2010	TTL is a member of the transthyretin-related protein family (TRP), which comprises a number of proteins with sequence homology to transthyretin (TTR) and the characteristic C-terminal sequence motif Tyr-Arg-Gly-Ser.	Arginine	203-206	coiled coil protein	Arabidopsis thaliana	0-3
20367944-14	2010	Spironolactone can inhibit the activation of L-Arg/iNOS/NO pathway.	Arginine	45-50	nitric oxide synthase 2	Rattus norvegicus	51-55
20025242-8	2010	Our observations suggest that Cdc25B and -C may adventitiously reduce arsenate to the more toxic arsenite and may also provide a framework for identifying other human protein tyrosine phosphatases containing the active site Cys-X(5)-Arg loop that might moonlight as arsenate reductases.	Arginine	233-236	cell division cycle 25B	Homo sapiens	30-36
20047279-9	2010	From this library, we found an improved clone, scFv#m2-c4 (K(a) = 6.3 x 10(8) M(-1); Lys(H19)Arg, Tyr(H56)Phe, Ser(H84)Pro, Glu(H85)Gly, Gln(L27)Arg, Leu(L36)Met, Ser(L63)Gly, and Ser(L77)Gly).	Arginine	93-96	immunglobulin heavy chain variable region	Homo sapiens	47-51
20047279-9	2010	From this library, we found an improved clone, scFv#m2-c4 (K(a) = 6.3 x 10(8) M(-1); Lys(H19)Arg, Tyr(H56)Phe, Ser(H84)Pro, Glu(H85)Gly, Gln(L27)Arg, Leu(L36)Met, Ser(L63)Gly, and Ser(L77)Gly).	Arginine	145-148	immunglobulin heavy chain variable region	Homo sapiens	47-51
19522661-7	2010	Rh-Epo association to the negatively charged head groups via lysine and arginine initiates this transformation.	Arginine	72-80	erythropoietin	Homo sapiens	3-6
20169177-5	2010	WDFY4 is a conserved protein with unknown function, but is predominantly expressed in primary and secondary immune tissues, and rs7097397 in WDFY4 changes an arginine residue to glutamine (R1816Q) in this protein.	Arginine	158-166	WDFY family member 4	Homo sapiens	0-5
20169177-5	2010	WDFY4 is a conserved protein with unknown function, but is predominantly expressed in primary and secondary immune tissues, and rs7097397 in WDFY4 changes an arginine residue to glutamine (R1816Q) in this protein.	Arginine	158-166	WDFY family member 4	Homo sapiens	141-146
20059978-2	2010	Crystallography of the REV1-DNA-dCTP ternary complex has revealed a unique mechanism by which template G is evicted from the DNA helix and incoming dCTP is recognized by an arginine residue in an alpha-loop, termed the N-digit.	Arginine	173-181	REV1 DNA directed polymerase	Homo sapiens	23-27
20181089-3	2010	The 19S ATPase Sug1 binds to histone-remodeling enzymes, and in the absence of Sug1, a subset of activating epigenetic modifications including histone H3 acetylation, H3 lysine 4 trimethylation and H3 arginine 17 dimethylation are inhibited at cytokine-inducible major histocompatibilty complex (MHC)-II and class II transactivator (CIITA) promoters, implicating Sug1 in events required to initiate mammalian transcription.	Arginine	201-209	proteasome 26S subunit, ATPase 5	Homo sapiens	15-19
20156100-7	2010	N-terminal domains were identified as critical for Nef-induced vesicle secretion: (1) a basic cluster of four arginine residues (aa 17, 19, 21, 22), (2) the phosphofurin acidic cluster sequence (PACS; Glu62-65), and (3) a previously uncharacterized domain spanning amino acid residues 66-70 (VGFPV), which we named the secretion modification region (SMR).	Arginine	110-118	S100 calcium binding protein B	Homo sapiens	51-54
19939821-5	2010	The association between PON1 genotype (192 Gln/Arg) and low-density lipoprotein cholesterol (LDL-C) (P = .036) levels was also observed.	Arginine	47-50	paraoxonase 1	Homo sapiens	24-28
19939821-5	2010	The association between PON1 genotype (192 Gln/Arg) and low-density lipoprotein cholesterol (LDL-C) (P = .036) levels was also observed.	Arginine	47-50	component of oligomeric golgi complex 2	Homo sapiens	56-91
19939821-5	2010	The association between PON1 genotype (192 Gln/Arg) and low-density lipoprotein cholesterol (LDL-C) (P = .036) levels was also observed.	Arginine	47-50	component of oligomeric golgi complex 2	Homo sapiens	93-98
19939821-7	2010	PON1 polymorphism 192Gln/Arg influenced the risk of premature MI.	Arginine	25-28	paraoxonase 1	Homo sapiens	0-4
19939821-8	2010	The association between PON1 genotype (192 Gln/Arg) and serum LDL-C levels may be explained by PON participation in reverse cholesterol transport.	Arginine	47-50	paraoxonase 1	Homo sapiens	24-28
19939821-8	2010	The association between PON1 genotype (192 Gln/Arg) and serum LDL-C levels may be explained by PON participation in reverse cholesterol transport.	Arginine	47-50	component of oligomeric golgi complex 2	Homo sapiens	62-67
19939821-8	2010	The association between PON1 genotype (192 Gln/Arg) and serum LDL-C levels may be explained by PON participation in reverse cholesterol transport.	Arginine	47-50	paraoxonase 1	Homo sapiens	24-27
20100277-0	2010	Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3.	Arginine	34-42	solute carrier organic anion transporter family member 1B3	Homo sapiens	107-149
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	27-35	albumin	Homo sapiens	67-70
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	27-35	albumin	Homo sapiens	96-99
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	27-35	albumin	Homo sapiens	96-99
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	37-40	albumin	Homo sapiens	67-70
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	37-40	albumin	Homo sapiens	96-99
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	37-40	albumin	Homo sapiens	96-99
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	144-147	albumin	Homo sapiens	67-70
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	144-147	albumin	Homo sapiens	96-99
19864017-7	2010	Chemical neutralization of arginine (Arg) residues in the adsorbed Alb layer inhibited platelet-Alb interactions significantly, indicating that Arg residues play a prominent role in mediating platelet adhesion to Alb.	Arginine	144-147	albumin	Homo sapiens	96-99
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20100277-4	2010	EXPERIMENTAL APPROACH: Residues Lys28, Lys41 and Arg580 in OATP1B3 were substituted by alanine, arginine, glutamine, glycine or lysine.	Arginine	96-104	solute carrier organic anion transporter family member 1B3	Homo sapiens	59-66
19783080-9	2010	RESULTS: Total lymphocyte yield, numbers of lymphocyte subpopulations, and intestinal IgA levels in the EN+ARG group were higher than those in the EN group (p&lt;0.05).	Arginine	107-110	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	86-89
19815563-4	2010	METHODS AND RESULTS: Mice lacking dystrophin due to a truncation mutation (mdx) were given an arginine-rich, cell-penetrating, peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) that delivered a splice-switching oligonucleotide-mediated exon skipping therapy to restore dystrophin in mdx mice before the development of detectable cardiomyopathy.	Arginine	94-102	dystrophin, muscular dystrophy	Mus musculus	75-78
19783080-10	2010	Levels of gut tissue cytokines were significantly altered with enteral Arg supplementation: levels of IL-4 and IL-10 were increased, and levels of IFN-gamma and IL-2 declined, when compared with the EN-fed mice (p&lt;0.05).	Arginine	71-74	interleukin 10	Mus musculus	111-116
19931521-1	2010	BACKGROUND: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to l-citruline for the action at the endothelial nitric oxide synthase (eNOS) is considered an important atheroprotective factor.	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	125-158
19931521-1	2010	BACKGROUND: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to l-citruline for the action at the endothelial nitric oxide synthase (eNOS) is considered an important atheroprotective factor.	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	160-164
19783080-10	2010	Levels of gut tissue cytokines were significantly altered with enteral Arg supplementation: levels of IL-4 and IL-10 were increased, and levels of IFN-gamma and IL-2 declined, when compared with the EN-fed mice (p&lt;0.05).	Arginine	71-74	interferon gamma	Mus musculus	147-156
19672627-3	2010	RESULTS: Compared with the major homozygotes at the Arg326Gln SNP in PTPRJ, a likely homologue of the mouse SCC1 (susceptible to colon cancer), Arg/Gln or Gln/Gln genotypes exhibited an increased colorectal cancer risk with adjusted odds ratios (aOR) of 1.71 (P = 0.021) and 3.74 (P = 4.14 x 10(-4)), respectively.	Arginine	52-55	protein tyrosine phosphatase, receptor type, J	Mus musculus	108-112
19672627-3	2010	RESULTS: Compared with the major homozygotes at the Arg326Gln SNP in PTPRJ, a likely homologue of the mouse SCC1 (susceptible to colon cancer), Arg/Gln or Gln/Gln genotypes exhibited an increased colorectal cancer risk with adjusted odds ratios (aOR) of 1.71 (P = 0.021) and 3.74 (P = 4.14 x 10(-4)), respectively.	Arginine	52-55	protein tyrosine phosphatase, receptor type, J	Mus musculus	69-74
20035717-0	2010	Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.	Arginine	39-47	ribosomal 40S subunit protein S2	Saccharomyces cerevisiae S288C	81-85
19822234-7	2010	Such recognition was mediated via a "second" arginine-glycine-aspartic acid (RGD) sequence that is present in the V95 subsegment in rat, but not human, FN.	Arginine	45-53	fibronectin 1	Homo sapiens	152-154
19838638-13	2010	The decrease in FE(NO) after aminoguanidine and subsequent partial reversal by L-arginine in both groups, suggests that Type II NOS contributes to the FE(NO) in both.	Arginine	79-89	nitric oxide synthase 2	Homo sapiens	120-131
19636643-7	2010	In stepwise linear regression analysis, the GH peak after GHRH + ARG was the major determinant of EWL% (p &lt; 0.0001) and FM (p = 0.001).	Arginine	65-68	growth hormone 1	Homo sapiens	44-46
19636643-9	2010	The percent of FM, FFM, and EWL were significantly correlated with the GH response to GHRH + ARG and with IGF-1 levels.	Arginine	93-96	growth hormone 1	Homo sapiens	71-73
19920152-5	2010	In studies employing the recombinant Kunitz domain of APP (APPI), we show that mesotrypsin cleaves selectively at the Arg(15)-Ala(16) reactive site bond, with kinetic constants approaching those of other proteases toward highly specific protein substrates.	Arginine	118-121	amyloid beta precursor protein	Homo sapiens	59-63
19822207-1	2010	Stimulated macrophages produce nitric oxide (NO) via inducible nitric oxide synthase (iNOS) using molecular O(2), L-arginine, and NADPH.	Arginine	114-124	nitric oxide synthase 2, inducible	Mus musculus	53-84
19822207-1	2010	Stimulated macrophages produce nitric oxide (NO) via inducible nitric oxide synthase (iNOS) using molecular O(2), L-arginine, and NADPH.	Arginine	114-124	nitric oxide synthase 2, inducible	Mus musculus	86-90
20082853-2	2010	To investigate the frequency of proline and arginine alleles of TP53 codon 72, the present study analyzed the DNA from blood samples of 30 Iranian women with endometrial cancer, in comparison with 32 healthy women.	Arginine	44-52	tumor protein p53	Homo sapiens	64-68
19954189-4	2010	When Ca(2+) is bound to both calmodulin lobes, the K(d) for the reference complex is not significantly affected, but the K(d) for the Ala variant decreases to 0.9 +/- 0.04 microM, and the values for the Arg and Met variants decrease to 0.4 +/- 0.03 microM.	Arginine	203-206	calmodulin 1	Homo sapiens	29-39
20090832-8	2010	An arginine residue at this position however, as found for example in MICA or ULBP3, would cause steric clashes with UL16 residues.	Arginine	3-11	membrane glycoprotein UL16	Human betaherpesvirus 5	117-121
19897710-5	2010	siRNA-mediated knockdown of either GR, TrxR1, or TrxR2 markedly suppressed VEGF-induced NO production (measured by an electrochemical NO sensor) and also blocked eNOS enzyme activity (using the [(3)H]arginine/[(3)H]citrulline assay).	Arginine	200-208	thioredoxin reductase 2	Homo sapiens	49-54
20029945-5	2010	Manipulations of NO biology, such as breathing NO or addition of arginine or L-NAME (N-nitro-L-arginine-methyl-ester) to the diet, caused significant modulations of TF expression.	Arginine	65-73	coagulation factor III	Mus musculus	165-167
20220325-4	2010	A functional human leptin receptor gene (LEPR) polymorphism, a glutamine to an arginine substitution at codon 223 (Gln223Arg), has been associated with insulin resistance capacity and an altered leptin-binding activity.	Arginine	79-87	insulin	Homo sapiens	152-159
19897710-5	2010	siRNA-mediated knockdown of either GR, TrxR1, or TrxR2 markedly suppressed VEGF-induced NO production (measured by an electrochemical NO sensor) and also blocked eNOS enzyme activity (using the [(3)H]arginine/[(3)H]citrulline assay).	Arginine	200-208	vascular endothelial growth factor A	Homo sapiens	75-79
20199997-4	2010	Through different mechanisms, some components of nuts such as magnesium, fiber, alpha-linolenic acid, L-arginine, antioxidants and MUFA may protect against inflammation and insulin resistance.	Arginine	102-112	insulin	Homo sapiens	173-180
20103956-1	2010	BACKGROUND AND OBJECTIVES: Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelial nitric oxide synthase (NOS3).	Arginine	78-88	nitric oxide synthase 3	Homo sapiens	92-125
20103956-1	2010	BACKGROUND AND OBJECTIVES: Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelial nitric oxide synthase (NOS3).	Arginine	78-88	nitric oxide synthase 3	Homo sapiens	127-131
21182780-7	2010	RESULTS: In total about two-thirds of the 81 arginines of human fibrinogen were found to be susceptible to citrullination by the human PAD2, the human PAD4 or the rabbit PAD2 enzymes.	Arginine	45-54	fibrinogen beta chain	Homo sapiens	64-74
19684035-3	2010	Arginase, an enzyme that competes with nitric oxide synthase (NOS) for l-arginine, not only reduces NO formation but also increases superoxide production by NOS.	Arginine	71-81	nitric oxide synthase 2	Homo sapiens	39-60
20648920-5	2010	In LPS-treated mesenteric artery, L-arginine-induced relaxation was not affected by removal of endothelium, indicating muscular inducible nitric oxide synthase (iNOS) induction.	Arginine	34-44	nitric oxide synthase 2	Rattus norvegicus	128-159
20648920-5	2010	In LPS-treated mesenteric artery, L-arginine-induced relaxation was not affected by removal of endothelium, indicating muscular inducible nitric oxide synthase (iNOS) induction.	Arginine	34-44	nitric oxide synthase 2	Rattus norvegicus	161-165
21338227-2	2010	In the tumour suppressor Trp53 gene, a codon 72 polymorphism is frequent in the form of a single nucleotide polymorphism that leads to substitution of an arginine for a proline.	Arginine	154-162	tumor protein p53	Homo sapiens	25-30
19900405-6	2010	The cleavage at arginine 570 is sensitive to a furin inhibitor.	Arginine	16-24	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	47-52
20606325-2	2010	CPR removes the C-terminal arginine from inflammatory peptides such as C3a and C5a, bradykinin, enkephalin, and the thrombin-cleaved N-terminal fragment osteopontin (cleaved N-OPN).	Arginine	27-35	hemolytic complement	Mus musculus	79-82
21071869-4	2010	After fifth-round panning of a hepta-peptide library against soluble Abeta(1-42), novel peptides containing arginine residues were enriched.	Arginine	108-116	amyloid beta precursor protein	Homo sapiens	69-74
21133638-5	2010	OBJECTIVE: The purpose of this study was to investigate the p53 polymorphism at codon 72 which results in encoding of either proline or arginine.	Arginine	136-144	tumor protein p53	Homo sapiens	60-63
20798521-0	2010	Calcium sensing receptor mutations implicated in pancreatitis and idiopathic epilepsy syndrome disrupt an arginine-rich retention motif.	Arginine	106-114	calcium sensing receptor	Homo sapiens	0-24
20798521-1	2010	Calcium sensing receptor (CaSR) mutations implicated in familial hypocalciuric hypercalcemia, pancreatitis and idiopathic epilepsy syndrome map to an extended arginine-rich region in the proximal carboxyl terminus.	Arginine	159-167	calcium sensing receptor	Homo sapiens	0-24
20798521-1	2010	Calcium sensing receptor (CaSR) mutations implicated in familial hypocalciuric hypercalcemia, pancreatitis and idiopathic epilepsy syndrome map to an extended arginine-rich region in the proximal carboxyl terminus.	Arginine	159-167	calcium sensing receptor	Homo sapiens	26-30
20798521-2	2010	Arginine-rich motifs mediate endoplasmic reticulum retention and/or retrieval of multisubunit proteins so we asked whether these mutations, R886P, R896H or R898Q, altered CaSR targeting to the plasma membrane.	Arginine	0-8	calcium sensing receptor	Homo sapiens	171-175
20798521-9	2010	A single arginine-rich region within the dimer was sufficient to confer intracellular retention comparable to wt CaSR.	Arginine	9-17	calcium sensing receptor	Homo sapiens	113-117
20798521-10	2010	We have identified an extended arginine-rich region in the proximal carboxyl terminus of CaSR (residues R890 - R898) which fosters intracellular retention of CaSR and is regulated by phosphorylation.	Arginine	31-39	calcium sensing receptor	Homo sapiens	89-93
20798521-10	2010	We have identified an extended arginine-rich region in the proximal carboxyl terminus of CaSR (residues R890 - R898) which fosters intracellular retention of CaSR and is regulated by phosphorylation.	Arginine	31-39	calcium sensing receptor	Homo sapiens	158-162
20563922-6	2010	The TP53 polymorphism distribution in this population was 64 (21.1%) Arg/Arg, 55 (18.1%) Pro/Pro, and 185 (60.9%) Arg/Pro.	Arginine	69-72	tumor protein p53	Homo sapiens	4-8
20130515-5	2010	RESULTS: Women homozygous for the p53 codon 72 Arg genotype were at a 5.6-fold higher risk for developing cervical intraepithelial neoplasia (CIN) 2 or 3 compared with those showing homozygosity for the Pro genotype or heterozygosity for the Pro/Arg genotype.	Arginine	47-50	tumor protein p53	Homo sapiens	34-37
20130515-5	2010	RESULTS: Women homozygous for the p53 codon 72 Arg genotype were at a 5.6-fold higher risk for developing cervical intraepithelial neoplasia (CIN) 2 or 3 compared with those showing homozygosity for the Pro genotype or heterozygosity for the Pro/Arg genotype.	Arginine	246-249	tumor protein p53	Homo sapiens	34-37
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Arginine	43-51	paraoxonase 1	Homo sapiens	0-4
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Arginine	43-51	paraoxonase 1	Homo sapiens	86-90
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Arginine	43-51	paraoxonase 1	Homo sapiens	86-90
19223938-3	2010	PON1 polymorphisms include a glutamine (Q)/arginine (R) substitution at position 192 (PON1(Q192R)) that affects hydrolysis of OP substrates, with the PON1(192Q) allotype hydrolyzing chlorpyrifos oxon less efficiently than the PON1(192R) allotype, a variation potentially important in determining susceptibility to chlorpyrifos.	Arginine	43-51	paraoxonase 1	Homo sapiens	86-90
19950230-8	2010	In conclusion, the substitution of amino aa70 of Arg for Gln in patients infected with HCV-1b increases with age, and it is associated with severe liver disease accompanied by elevated AST and gamma-GTP levels, as well as the development of hepatocellular carcinoma.	Arginine	49-52	solute carrier family 17 member 5	Homo sapiens	185-188
19808892-10	2010	Second-phase GSIS, insulin sensitivity index and GLP-1, or arginine-stimulated insulin release were not significantly different.	Arginine	59-67	insulin	Homo sapiens	79-86
19808892-12	2010	The slower second-phase GSIS, GLP-1, and arginine-stimulated insulin secretion are not associated, suggesting that especially processes involved in rapid granule recruitment and exocytosis are affected in the majority of risk loci.	Arginine	41-49	insulin	Homo sapiens	61-68
19249120-1	2010	High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO.	Arginine	128-131	interferon gamma	Homo sapiens	91-99
19858193-1	2010	Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	64-67	coagulation factor II, thrombin	Homo sapiens	3-11
19858193-1	2010	Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	97-100	coagulation factor II, thrombin	Homo sapiens	3-11
20505276-7	2010	Furthermore, polymerase chain reaction-single-strand conformation polymorphism and following nucleotide sequencing showed that the p53 gene was mutated at codon 215, leading to an amino acid substitution from Ser to Arg.	Arginine	216-219	tumor protein p53	Homo sapiens	131-134
20563922-6	2010	The TP53 polymorphism distribution in this population was 64 (21.1%) Arg/Arg, 55 (18.1%) Pro/Pro, and 185 (60.9%) Arg/Pro.	Arginine	73-76	tumor protein p53	Homo sapiens	4-8
20563922-6	2010	The TP53 polymorphism distribution in this population was 64 (21.1%) Arg/Arg, 55 (18.1%) Pro/Pro, and 185 (60.9%) Arg/Pro.	Arginine	73-76	tumor protein p53	Homo sapiens	4-8
20303810-1	2010	N-acetylglutamate (NAG) is a unique enzyme cofactor, essential for liver ureagenesis in mammals while it is the first committed substrate for de novo arginine biosynthesis in microorganisms and plants.	Arginine	150-158	N-acetyl-alpha-glucosaminidase	Homo sapiens	19-22
20635792-4	2010	Exon-specific amplification of genomic DNA by polymerase chain reaction followed by direct sequence analysis revealed a novel homozygous missense mutation at codon 48 in the C1q C gene causing a glycine-to-arginine substitution affecting the collagen-like region of C1q.	Arginine	206-214	complement C1q C chain	Homo sapiens	174-179
20303810-2	2010	The enzyme that produces NAG from glutamate and CoA, NAG synthase (NAGS), is allosterically inhibited by arginine in microorganisms and plants and activated in mammals.	Arginine	105-113	N-acetyl-alpha-glucosaminidase	Homo sapiens	25-28
20037594-3	2010	We show here that the HNA-3a antigen arises from a nucleotide polymorphism in the choline transporter-like protein-2 gene (SLC44A2), with the resulting variation at amino acid position 154 determining the reactivity of the protein with HNA-3a-specific antibodies; the variant with an arginine at this position, rather than a glutamine, constitutes the HNA-3a antigen.	Arginine	284-292	solute carrier family 44 member 2	Homo sapiens	82-116
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	vascular endothelial growth factor A	Homo sapiens	71-75
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	tumor protein p53	Homo sapiens	216-219
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	BCL2 apoptosis regulator	Homo sapiens	224-229
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	45-50	BCL2 associated X, apoptosis regulator	Homo sapiens	262-265
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	vascular endothelial growth factor A	Homo sapiens	71-75
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	tumor protein p53	Homo sapiens	216-219
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	BCL2 apoptosis regulator	Homo sapiens	224-229
20117988-10	2010	In cells treated with a low concentration of L-Arg, the expressions of VEGF and COX-2 were increased as compared with those in the control cells; higher concentrations of L-Arg obviously decreased the expressions of p53 and bcl-2 and increased the expression of bax.	Arginine	171-176	BCL2 associated X, apoptosis regulator	Homo sapiens	262-265
20037594-3	2010	We show here that the HNA-3a antigen arises from a nucleotide polymorphism in the choline transporter-like protein-2 gene (SLC44A2), with the resulting variation at amino acid position 154 determining the reactivity of the protein with HNA-3a-specific antibodies; the variant with an arginine at this position, rather than a glutamine, constitutes the HNA-3a antigen.	Arginine	284-292	solute carrier family 44 member 2	Homo sapiens	123-130
19904741-2	2010	ApoE3 and apoE4 differ in only a single amino acid with an arginine in apoE4 changed to a cysteine at position 112 in apoE3.	Arginine	59-67	apolipoprotein E	Homo sapiens	0-5
20117988-11	2010	CONCLUSION: Low-concentration L-Arg can promote the growth of LS174 cells probably by up-regulating VEGF and COX-2 protein under the influence of NO, the metabolite of L-Arg.	Arginine	30-35	vascular endothelial growth factor A	Homo sapiens	100-104
20117988-11	2010	CONCLUSION: Low-concentration L-Arg can promote the growth of LS174 cells probably by up-regulating VEGF and COX-2 protein under the influence of NO, the metabolite of L-Arg.	Arginine	30-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
20117988-13	2010	The mechanism of L-Arg- induced cell apoptosis may be related to the up-regulation of bax protein and the down-regulation of p53 and bcl-2 proteins.	Arginine	17-22	BCL2 associated X, apoptosis regulator	Homo sapiens	86-89
20117988-13	2010	The mechanism of L-Arg- induced cell apoptosis may be related to the up-regulation of bax protein and the down-regulation of p53 and bcl-2 proteins.	Arginine	17-22	tumor protein p53	Homo sapiens	125-128
20117988-13	2010	The mechanism of L-Arg- induced cell apoptosis may be related to the up-regulation of bax protein and the down-regulation of p53 and bcl-2 proteins.	Arginine	17-22	BCL2 apoptosis regulator	Homo sapiens	133-138
19508206-4	2010	Herein, we report the further design of the lead peptide 1 by addition of an Arg-Gly-Asp sequence to 1 to enhance binding to Grb2-SH2 and inducing apoptosis in cancer cells.	Arginine	77-80	growth factor receptor bound protein 2	Homo sapiens	125-129
19904741-2	2010	ApoE3 and apoE4 differ in only a single amino acid with an arginine in apoE4 changed to a cysteine at position 112 in apoE3.	Arginine	59-67	apolipoprotein E	Homo sapiens	10-15
19904741-2	2010	ApoE3 and apoE4 differ in only a single amino acid with an arginine in apoE4 changed to a cysteine at position 112 in apoE3.	Arginine	59-67	apolipoprotein E	Homo sapiens	71-76
19820234-8	2009	The reduction in NO production following DDAH-1 gene silencing was associated with a 48% reduction in l-Arg/ADMA and was partially restored with l-Arg supplementation.	Arginine	102-107	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	41-47
19800904-1	2010	Arginase1 and nitric oxide synthase2 (NOS2) utilize l-arginine as a substrate, with both enzymes expressed at high levels in the asthmatic lung.	Arginine	52-62	nitric oxide synthase 2, inducible	Mus musculus	14-36
19800904-1	2010	Arginase1 and nitric oxide synthase2 (NOS2) utilize l-arginine as a substrate, with both enzymes expressed at high levels in the asthmatic lung.	Arginine	52-62	nitric oxide synthase 2, inducible	Mus musculus	38-42
19800904-2	2010	Inhibition of arginase in ovalbumin-exposed C57BL/6 mice with the transition state inhibitor N(omega)-hydroxy-nor-l-arginine (nor-NOHA) significantly increased total l-arginine content in the airway compartment.	Arginine	114-124	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	26-35
19800904-13	2010	The increased l-arginine content in the airway compartment of mice treated with nor-NOHA may directly or indirectly, through NOS2, control arginase expression both in response to OVA exposure and at a basal level.	Arginine	14-24	nitric oxide synthase 2, inducible	Mus musculus	125-129
20356475-2	2010	METHODS: Plasma insulin level was detected in 201 cases before and after L-ARG stimulation test.	Arginine	73-78	insulin	Homo sapiens	16-23
20062922-6	2010	An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation of FVIII by modestly accelerating cleavage at Arg(372).	Arginine	193-196	coagulation factor II, thrombin	Homo sapiens	107-115
20062922-11	2010	This enhancing effect could be attributed to an increase in thrombin-induced activation of FVIII, mediated by cleavage at Arg(372) and a tighter interaction of thrombin with the A2 domain.	Arginine	122-125	coagulation factor II, thrombin	Homo sapiens	60-68
19820234-8	2009	The reduction in NO production following DDAH-1 gene silencing was associated with a 48% reduction in l-Arg/ADMA and was partially restored with l-Arg supplementation.	Arginine	145-150	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	41-47
19809807-2	2009	Substrate proteins of the Tat pathway are synthesised with signal peptides bearing SRRxFLK "twin-arginine" amino acid motifs.	Arginine	97-105	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	26-29
20560553-2	2009	Fibronectin is a predominant ECM protein that engages integrin cell receptors through its Arg-Gly-Asp (RGD) and Pro-His-Ser-Arg-Asn (PHSRN) peptide binding sites.	Arginine	90-93	fibronectin 1	Homo sapiens	0-11
20560553-2	2009	Fibronectin is a predominant ECM protein that engages integrin cell receptors through its Arg-Gly-Asp (RGD) and Pro-His-Ser-Arg-Asn (PHSRN) peptide binding sites.	Arginine	124-127	fibronectin 1	Homo sapiens	0-11
20641262-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
20641458-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
20641917-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
20641584-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5.	Arginine	21-24	fibrinogen beta chain	Homo sapiens	134-144
19666111-5	2009	Mutant hCRMP-2, lacking arginine residues responsible for GAP activity, inhibited microtubule assembly and neurite formation.	Arginine	24-32	dihydropyrimidinase like 2	Homo sapiens	7-14
19764997-6	2009	Single nucleotide polymorphisms (SNPs) in TP53 (codon 72, arginine &gt; proline) and MDM2 (SNP309, T &gt; G) were genotyped using PCR-RFLP, and nuclear expression levels of p53 were examined using immunohistochemistry.	Arginine	58-66	tumor protein p53	Homo sapiens	42-46
19879767-0	2009	Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.	Arginine	37-40	prepronociceptin	Homo sapiens	53-63
19879767-1	2009	[Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin.	Arginine	1-4	prepronociceptin	Homo sapiens	17-27
19879767-1	2009	[Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin.	Arginine	1-4	prepronociceptin	Homo sapiens	169-179
19879767-5	2009	In contrast, Asp206Ala and Tyr207Ala exhibited considerably reduced activity for [Arg(14),Lys(15)]nociceptin, exhibiting no synergistic activity enhancement.	Arginine	82-85	prepronociceptin	Homo sapiens	98-108
19879767-6	2009	These results suggest that Asp206 and Tyr207 are directly involved in the interaction with nociceptin-[Arg(14),Lys(15)].	Arginine	103-106	prepronociceptin	Homo sapiens	91-101
19879767-7	2009	Trp208Ala was found to bind strongly both nociceptin and [Arg(14),Lys(15)]nociceptin, although it elicited no biological activity.	Arginine	58-61	prepronociceptin	Homo sapiens	74-84
19524336-2	2009	The intake of protein as well as the specific amino acids arginine and lysine potently stimulate GH secretion.	Arginine	58-66	growth hormone 1	Homo sapiens	97-99
19821261-10	2009	In conclusion, preservation solutions attenuate accumulation and nuclear translocation of the transcription factor HIF-1alpha, and this property is seemingly related to their chemical composition (L-arginine, alpha-ketoglutarate).	Arginine	197-207	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Arginine	1-4	growth factor receptor bound protein 14	Homo sapiens	159-198
19802603-1	2009	AIMS/HYPOTHESIS: The aim of the present study was to estimate the heritability of the beta cell insulin response to glucose and to glucose combined with glucagon-like peptide-1 (GLP-1) or with GLP-1 plus arginine.	Arginine	204-212	insulin	Homo sapiens	96-103
19802603-4	2009	Insulin response of the beta cell was assessed by a modified hyperglycaemic clamp with additional GLP-1 and arginine.	Arginine	108-116	insulin	Homo sapiens	0-7
19802603-7	2009	RESULTS: The heritability of insulin levels in response to glucose was 52% and 77% for the first and second phase, respectively, 53% in response to glucose + GLP-1 and 80% in response to an additional arginine bolus.	Arginine	201-209	insulin	Homo sapiens	29-36
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Arginine	1-4	growth factor receptor bound protein 14	Homo sapiens	200-205
19802603-8	2009	Insulin responses to the administration of glucose, glucose + GLP-1 and glucose + GLP-1 + arginine were highly correlated (0.62&lt; r &lt;0.79).	Arginine	90-98	insulin	Homo sapiens	0-7
19802603-8	2009	Insulin responses to the administration of glucose, glucose + GLP-1 and glucose + GLP-1 + arginine were highly correlated (0.62&lt; r &lt;0.79).	Arginine	90-98	glucagon	Homo sapiens	82-87
19834685-8	2009	CONCLUSIONS/INTERPRETATION: The data describe a unique processing pathway for the endosomal proteolysis of [Arg(A0)]-HI which involves the removal of Arg(A0) and subsequent generation of mature human insulin through an uncovered neutral Arg-aminopeptidase activity.	Arginine	108-111	insulin	Homo sapiens	200-207
19409491-1	2009	Synthesis of nitric oxide (NO) can be blocked by inhibition of nitric oxide synthase (NOS) active site with guanidino-substituted analogues of l-arginine such as asymmetric dimethylarginine (ADMA).	Arginine	143-153	nitric oxide synthase 2	Homo sapiens	63-84
19934275-6	2009	Under arginine depletion conditions, HIF-1alpha was replaced by c-Myc in A2058 and SK-MEL-2 cells but not in A375 cells.	Arginine	6-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
19508594-4	2009	METHODS: Peak GH was assessed by GHRH/arginine stimulation testing.	Arginine	38-46	growth hormone 1	Homo sapiens	14-16
19918066-5	2009	In addition, mass spectrometry indicates that arginine residues in RG repeats at the N-termini of Miwi and Mili are methylated in vivo.	Arginine	46-54	piwi-like RNA-mediated gene silencing 2	Mus musculus	107-111
19951175-10	2009	An arginine-rich nuclear localization signal was found in 27 amino acids specific for Mx1B.	Arginine	3-11	MX dynamin like GTPase 1	Bos taurus	86-90
19897717-4	2009	ART1 on the surface of airway epithelial cells ADP-ribosylated HNP-1 specifically on arginines 14 and 24, with ADP-ribosylation altering biological activity.	Arginine	85-94	ADP-ribosyltransferase 1	Homo sapiens	0-4
19741270-4	2009	Moreover, chromatin immunoprecipitation assays show that PRMT5 is recruited to the L-type aldolase A promoter and that methylation of the nucleosomes that surround the L-type promoter region occurs in vivo on the arginine 3 of histone H4.	Arginine	213-221	protein arginine methyltransferase 5	Homo sapiens	57-62
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Arginine	128-136	ADP-ribosyltransferase 1	Homo sapiens	39-43
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Arginine	165-173	ADP-ribosyltransferase 1	Homo sapiens	39-43
19717558-11	2009	The corresponding arginine substitution in Kv6.4 prevented its heterotetrameric interaction with Kv2.1.	Arginine	18-26	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	43-48
19887642-4	2009	Substitution of Arg for these residues confers Vif resistance and restores A3G"s antiviral activity in the presence of Vif.	Arginine	16-19	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	75-78
19843866-5	2009	The PADI4 gene encodes an enzyme catalyzing the citrullination of arginine residues in proteins, and ectopic expression of p53 or PADI4 induced protein citrullination.	Arginine	66-74	tumor protein p53	Homo sapiens	123-126
18853251-1	2009	The p53 tumor suppressor gene has a central role in the defense against cancer, including breast cancer, and contains a polymorphic variant (Arg/Pro) at codon 72 that has been shown to have different biological properties regarding apoptosis and cell cycle arrest.	Arginine	141-144	tumor protein p53	Homo sapiens	4-7
19818773-2	2009	The currently-accepted mechanism involves removal of a constraint on the antithrombin reactive center loop (RCL) so that the proteinase can simultaneously engage both the P1 arginine and an exosite at Y253.	Arginine	174-182	endogenous retrovirus group K member 25	Homo sapiens	125-135
19630535-6	2009	Most importantly, of the 202 GPR42 alleles that were genotyped, 123 (61%) had arginine at amino acid 174, suggesting that GPR42 could potentially be a functional gene in a significant fraction of the human population and should therefore not be categorically characterized as an inactive pseudogene.	Arginine	78-86	G protein-coupled receptor 42	Homo sapiens	122-127
19427400-6	2009	A typical fibronectin type III (FNIII) domain was identified in p48.2 between Arg(176) and Pro(261) in which a palindromic Arg-Gly-Asp (RGD) repeat plus a putative Trp-Ser-X-Trp-Ser (WSXWS) motif were found at the domain"s C-terminus.	Arginine	78-81	interferon regulatory factor 9	Homo sapiens	64-67
19924604-7	2009	RESULTS: Insulin levels reached to peak values at the 2 (nd) hour, and decreased to baseline levels at the 5 (th) hour measurements both after the ingestion of mixed meal only and after the ingestion of mixed meal plus oral L-Arginine.	Arginine	224-234	insulin	Homo sapiens	9-16
19924604-8	2009	First and 2 (nd) hour insulin levels were significantly higher after the ingestion of mixed meal plus oral L-Arginine.	Arginine	107-117	insulin	Homo sapiens	22-29
19924604-10	2009	Increments regarding serum insulin levels after the ingestion of mixed meal plus oral L-Arginine suggest that oral L-Arginine could be benefical for the evaluation of beta cell function and secretory defects.	Arginine	86-96	insulin	Homo sapiens	27-34
19924604-10	2009	Increments regarding serum insulin levels after the ingestion of mixed meal plus oral L-Arginine suggest that oral L-Arginine could be benefical for the evaluation of beta cell function and secretory defects.	Arginine	115-125	insulin	Homo sapiens	27-34
19874399-6	2009	Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P= 0.0212).	Arginine	49-52	tumor protein p53	Homo sapiens	69-72
19874399-6	2009	Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P= 0.0212).	Arginine	53-56	tumor protein p53	Homo sapiens	69-72
19427400-6	2009	A typical fibronectin type III (FNIII) domain was identified in p48.2 between Arg(176) and Pro(261) in which a palindromic Arg-Gly-Asp (RGD) repeat plus a putative Trp-Ser-X-Trp-Ser (WSXWS) motif were found at the domain"s C-terminus.	Arginine	123-126	interferon regulatory factor 9	Homo sapiens	64-67
19747845-7	2009	The significance of arginine in the interactions was studied by comparing the affinities of synthesized peptides VCGERGF and VCGEAGF with ILPR variant a. Peptides from other regions of the proteins that are connected through disulfide linkages were also detected in some capture experiments.	Arginine	20-28	insulin	Homo sapiens	138-142
19773395-1	2009	OBJECTIVE: The objective of the study was to reevaluate the diagnostic accuracy of GH peak after GHRH plus arginine test (GHRH+ARG) according to patients" age, body mass index (BMI), and waist circumference to diagnose GH deficiency (GHD).	Arginine	107-115	growth hormone releasing hormone	Homo sapiens	122-126
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	143-146	G protein-coupled receptor 162	Homo sapiens	85-91
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	147-150	G protein-coupled receptor 162	Homo sapiens	85-91
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	147-150	G protein-coupled receptor 162	Homo sapiens	85-91
19837749-4	2009	Therefore, we hypothesized that ReCCMSH(Arg(11)) could be a good platform for the further development of an (18)F-labeled probe for PET of MC1R-positive malignant melanoma.	Arginine	40-43	melanocortin 1 receptor	Mus musculus	139-143
19823748-0	2009	Arginine-based PNA microarrays for APOE genotyping.	Arginine	0-8	apolipoprotein E	Homo sapiens	35-39
19726520-4	2009	Tat stabilization depends on the catalytic activity of PRMT6 and requires arginine methylation within the Tat basic domain.	Arginine	74-82	protein arginine methyltransferase 6	Homo sapiens	55-60
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Arginine	91-99	tumor protein p53	Homo sapiens	18-21
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Arginine	91-99	tumor protein p53	Homo sapiens	191-194
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Arginine	101-104	tumor protein p53	Homo sapiens	18-21
19423162-2	2009	A G-C exchange at p53 codon 72 polymorphism results in a substitution of proline (Pro) for arginine (Arg) in the transactivation domain, which was shown to alter the primary structure of the p53 protein.	Arginine	101-104	tumor protein p53	Homo sapiens	191-194
19737939-8	2009	The CaM-binding region together with bound CaM forms a hinge, pivots on the conserved Arg(536), and regulates electron transfer from FAD to FMN and from FMN to heme by adjusting the relative orientation and distance among the three cofactors.	Arginine	86-89	calmodulin 1	Homo sapiens	4-7
19544422-7	2009	In CARM1 overexpressing ES cells, histone H3 arginine methylation is also at the Nanog promoter to which CARM1 now associates.	Arginine	45-53	Nanog homeobox	Mus musculus	81-86
19744924-11	2009	Further mutational analysis suggested that additional mechanisms associated with methylation of Mre11 at the C-terminal glycine-arginine-rich domain contributed to the promotion of D-NHEJ by Mre11.	Arginine	128-136	MRE11 homolog, double strand break repair nuclease	Homo sapiens	96-101
19744924-11	2009	Further mutational analysis suggested that additional mechanisms associated with methylation of Mre11 at the C-terminal glycine-arginine-rich domain contributed to the promotion of D-NHEJ by Mre11.	Arginine	128-136	MRE11 homolog, double strand break repair nuclease	Homo sapiens	191-196
20067119-7	2009	The apoB100 levels increased in the non-obese females with genotype Arg/Arg and decreased in the obese females with Arg/Gly (P &lt; 0.05 ).	Arginine	68-71	apolipoprotein B	Homo sapiens	4-11
20067119-7	2009	The apoB100 levels increased in the non-obese females with genotype Arg/Arg and decreased in the obese females with Arg/Gly (P &lt; 0.05 ).	Arginine	72-75	apolipoprotein B	Homo sapiens	4-11
20067119-7	2009	The apoB100 levels increased in the non-obese females with genotype Arg/Arg and decreased in the obese females with Arg/Gly (P &lt; 0.05 ).	Arginine	72-75	apolipoprotein B	Homo sapiens	4-11
20067119-8	2009	The apoA I and apoA II levels decreased in the obese and non-obese males with Arg/Arg (P &lt; 0.05).	Arginine	78-81	apolipoprotein A1	Homo sapiens	4-10
20067119-8	2009	The apoA I and apoA II levels decreased in the obese and non-obese males with Arg/Arg (P &lt; 0.05).	Arginine	82-85	apolipoprotein A1	Homo sapiens	4-10
19737939-8	2009	The CaM-binding region together with bound CaM forms a hinge, pivots on the conserved Arg(536), and regulates electron transfer from FAD to FMN and from FMN to heme by adjusting the relative orientation and distance among the three cofactors.	Arginine	86-89	calmodulin 1	Homo sapiens	43-46
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Arginine	84-92	tumor necrosis factor	Mus musculus	102-110
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Arginine	84-92	tumor necrosis factor	Mus musculus	152-160
19911071-6	2009	It is generated from the amino acid L-arginine via constitutive and inducible isoforms of the enzyme NO synthase (NOS).	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	101-112
19717177-8	2009	Interestingly, despite the presence of similar levels of Arg-A3G (t1/2=28 min) and Asp-A3G (t1/2=65 min) into HIV-1 Deltavif virions, inhibition of viral infectivity was only evident in the presence of A3G proteins with a longer half-life (t1/2 &gt; or = 65 min).	Arginine	57-60	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	61-64
19666463-2	2009	Arg-61 apoE mice, a gene-targeted mouse model specific for domain interaction, have lower brain apoE levels and synaptic, functional, and cognitive deficits.	Arginine	0-3	apolipoprotein E	Mus musculus	7-11
19523991-6	2009	V-1880 ([deamino-Pen(1), O-Me-Tyr(2), Arg(8)]-Vasopressin, 10(-7) M), a V(1) receptor antagonist, inhibited the spontaneous contraction of the strips.	Arginine	38-41	arginine vasopressin	Rattus norvegicus	46-57
19191256-7	2009	We observed significant allelic and genotypic associations of the PCNT2 SNPs, rs2249057, rs2268524, and rs2073380 (Ser/Arg) with schizophrenia; the association of rs2249057 (P = 0.002) withstand multiple testing correction.	Arginine	119-122	pericentrin	Homo sapiens	66-71
19666463-2	2009	Arg-61 apoE mice, a gene-targeted mouse model specific for domain interaction, have lower brain apoE levels and synaptic, functional, and cognitive deficits.	Arginine	0-3	apolipoprotein E	Mus musculus	96-100
19666463-3	2009	We hypothesized that domain interaction elicits an endoplasmic reticulum (ER) stress in astrocytes and an unfolded protein response that targets Arg-61 apoE for degradation.	Arginine	145-148	apolipoprotein E	Mus musculus	152-156
19666463-4	2009	Primary Arg-61 apoE astrocytes had less intracellular apoE than wild-type astrocytes, and unfolded protein response markers OASIS (old astrocyte specifically induced substance), ATF4, and XBP-1 and downstream effectors were up-regulated.	Arginine	8-11	apolipoprotein E	Mus musculus	15-19
19666463-4	2009	Primary Arg-61 apoE astrocytes had less intracellular apoE than wild-type astrocytes, and unfolded protein response markers OASIS (old astrocyte specifically induced substance), ATF4, and XBP-1 and downstream effectors were up-regulated.	Arginine	8-11	apolipoprotein E	Mus musculus	54-58
19819787-8	2009	RESULTS: At baseline, plasma level of NOx, L-arginine, and L-arginine/ADMA ratio were lower (p&lt;0.001 for all) in patients with CSX than in the control patients.	Arginine	43-53	NK2 homeobox 5	Homo sapiens	130-133
19666463-5	2009	ER stress appears to cause global astrocyte dysfunction as glucose uptake was decreased in Arg-61 apoE astrocytes, and astrocyte-conditioned medium promoted neurite outgrowth less efficiently than wild-type medium in Neuro-2a cell cultures.	Arginine	91-94	apolipoprotein E	Mus musculus	98-102
19666463-6	2009	We showed age-dependent up-regulation of brain OASIS levels and processing in Arg-61 apoE mice.	Arginine	78-81	apolipoprotein E	Mus musculus	85-89
19819787-8	2009	RESULTS: At baseline, plasma level of NOx, L-arginine, and L-arginine/ADMA ratio were lower (p&lt;0.001 for all) in patients with CSX than in the control patients.	Arginine	59-69	NK2 homeobox 5	Homo sapiens	130-133
19819787-14	2009	CONCLUSION: Circulating endothelial function parameters (plasma ADMA, L-arginine, NOx levels) were impaired in patients with CSX.	Arginine	70-80	NK2 homeobox 5	Homo sapiens	125-128
19485892-0	2009	A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia.	Arginine	22-32	insulin	Homo sapiens	11-18
19485892-7	2009	It has been shown that insulin blocks D-glucose-increased L-arginine transport and cGMP accumulation in HUVEC, whereas in this cell type insulin also modulates high D-glucose effects by activating the transcriptional factors Sp1 and NFkappaB.	Arginine	58-68	insulin	Homo sapiens	23-30
19485892-9	2009	Recent evidences suggest that insulin blocks the stimulatory effect of D-glucose on L-arginine transport by reducing the transcriptional activity of SLC7A1 via Sp1-, NFkappaB- and ROS-dependent mechanisms.	Arginine	84-94	insulin	Homo sapiens	30-37
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	coagulation factor II, thrombin	Homo sapiens	0-8
19521721-5	2009	Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage.	Arginine	56-64	tumor protein p53	Homo sapiens	39-43
18930193-1	2009	OBJECTIVE: To determine whether the p53 codon 72 single nucleotide polymorphism, a change of the amino acid arginine (Arg) to proline (Pro) resulting from a single nucleotide mutation of guanine (G) to cytosine (C), has a clinically significant effect on implantation rate in fresh IVF cycles.	Arginine	118-121	tumor protein p53	Homo sapiens	36-39
19608678-3	2009	Recently, we discovered a new natural post-translational modification of CXCL8, i.e. the deimination of arginine into citrulline by peptidylarginine deiminases.	Arginine	104-112	interleukin-8	Oryctolagus cuniculus	73-78
19485892-9	2009	Recent evidences suggest that insulin blocks the stimulatory effect of D-glucose on L-arginine transport by reducing the transcriptional activity of SLC7A1 via Sp1-, NFkappaB- and ROS-dependent mechanisms.	Arginine	84-94	nuclear factor kappa B subunit 1	Homo sapiens	166-175
19521721-5	2009	Similarly, the alleles of rs1042522 in TP53 that encode arginine (G-allele) or proline (C-allele) at codon 72, which cause increased pro-apoptotic (G-allele) or cell-cycle arrest activities (C-allele), respectively, may moderate p53"s ability to prevent DNA damage.	Arginine	56-64	tumor protein p53	Homo sapiens	229-232
19583440-0	2009	An insight to the dynamics of conserved water molecular triad in IMPDH II (human): recognition of cofactor and substrate to catalytic Arg 322.	Arginine	134-137	inosine monophosphate dehydrogenase 2	Homo sapiens	65-73
19730129-2	2009	It is synthesized by endothelium from arginine with the catalytic help of endothelial NO synthase (eNOS).	Arginine	38-46	nitric oxide synthase 3	Homo sapiens	99-103
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19347867-7	2009	Enzymatic assays using different recombinant COX-2 variants showed that COX-2-(587)Arg had significantly higher activity towards arachidonic acid than COX-2-(587)Gly (13.8 +/- 3.2 U/mg vs. 11.2 +/- 2.4 U/mg; P = 0.012).	Arginine	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
19806578-6	2009	The nonsense mutation of C to T was detected at the nucleotide 1143, which converted the Arg codon (CGA) to a stop codon(TGA) (R261X) in exon 10.	Arginine	89-92	chromogranin A	Homo sapiens	100-103
19526276-2	2009	NO is synthesized through the conversion of L-arginine to L-citrulline by the enzyme NO synthase (NOS), which is found in three isoforms classified as neuronal (nNOS), inducible (iNOS), and endothelial (eNOS).	Arginine	44-54	nitric oxide synthase 2	Homo sapiens	179-183
19526276-2	2009	NO is synthesized through the conversion of L-arginine to L-citrulline by the enzyme NO synthase (NOS), which is found in three isoforms classified as neuronal (nNOS), inducible (iNOS), and endothelial (eNOS).	Arginine	44-54	nitric oxide synthase 3	Homo sapiens	203-207
19558415-3	2009	Here, we report on a panel of tripeptide analogs consisting of a modified alpha-MSH core His(6)-d-Phe(7)-Arg(8), which contained different N-capping groups, C-terminal modifications, or arginine mimics.	Arginine	105-108	proopiomelanocortin	Homo sapiens	74-83
19672877-4	2009	A comparison of class A beta-lactamase sequences reveals that arginine at position 244 is not conserved, although a positive charge at this structural location is conserved and is provided by an arginine at positions 220 or 276 for those enzymes lacking arginine at position 244.	Arginine	195-203	amyloid beta precursor protein	Homo sapiens	22-28
19672877-4	2009	A comparison of class A beta-lactamase sequences reveals that arginine at position 244 is not conserved, although a positive charge at this structural location is conserved and is provided by an arginine at positions 220 or 276 for those enzymes lacking arginine at position 244.	Arginine	195-203	amyloid beta precursor protein	Homo sapiens	22-28
19951554-5	2009	RESULTS: Serum contents of TNF-alpha and IL-1beta of patients in all groups increased rapidly after burn, and although contents of TNF-alpha (318 +/- 57) ng/mL and IL-1beta (218 +/- 47) pg/mL of patients in L-arginine 200 mg group peaked on PBD 5, they were still significantly lower than those of patients in control group [(389 +/- 34) ng/mL, (272 +/- 40) pg/mL, P &lt; 0.05], but they decreased on PBD 7.	Arginine	207-217	tumor necrosis factor	Homo sapiens	27-36
19951554-6	2009	Serum contents of TNF-alpha and IL-1beta in L-arginine 400 mg group were close to those of control group (P &gt; 0.05).	Arginine	44-54	tumor necrosis factor	Homo sapiens	18-27
19393615-3	2009	In this work, we have studied the peptide-membrane interactions of a model beta-sheet peptide, P(11-2) (CH(3)CO-Gln-Gln-Arg-Phe-Gln-Trp-Gln-Phe-Glu-Gln-Gln-NH(2)), by fluorescence, infrared spectroscopy, and hydrogen-deuterium exchange.	Arginine	120-123	proteasome 26S subunit, non-ATPase 1	Homo sapiens	95-101
19951554-6	2009	Serum contents of TNF-alpha and IL-1beta in L-arginine 400 mg group were close to those of control group (P &gt; 0.05).	Arginine	44-54	interleukin 1 beta	Homo sapiens	32-40
19951554-7	2009	Serum contents of TGF-beta(1) and IL-4 of patients in each group increased slowly after burn, and content of TGF-beta(1) (110 +/- 16) pg/mL of patients in L-arginine 200 mg group was significantly higher than that of patients in control group [(83 +/- 20) pg/mL, P &lt; 0.05] on PBD 5.	Arginine	155-165	transforming growth factor beta 1	Homo sapiens	18-29
19951554-7	2009	Serum contents of TGF-beta(1) and IL-4 of patients in each group increased slowly after burn, and content of TGF-beta(1) (110 +/- 16) pg/mL of patients in L-arginine 200 mg group was significantly higher than that of patients in control group [(83 +/- 20) pg/mL, P &lt; 0.05] on PBD 5.	Arginine	155-165	transforming growth factor beta 1	Homo sapiens	109-120
19784392-8	2009	CONCLUSIONS: Our preliminary results indicate that the arginine variant of rs1042522 within p53 is associated with increased risk of POAG.	Arginine	55-63	tumor protein p53	Homo sapiens	92-95
19581304-2	2009	To map the residues in the drug translocation pathway, we performed arginine-scanning mutagenesis on all transmembrane (TM) segments (total = 237 residues) of a P-gp processing mutant (G251V) defective in folding (15% maturation efficiency) (glycosylation state used to monitor folding).	Arginine	68-76	ATP binding cassette subfamily B member 1	Homo sapiens	161-165
19581304-3	2009	The rationale was that arginines introduced into the drug-binding sites would mimic drug rescue and enhance maturation of wild-type or processing mutants of P-gp.	Arginine	23-32	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
19581304-7	2009	It was found that many of the enhancer arginines caused large alterations in P-gp-drug interactions in ATPase assays.	Arginine	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Arginine	22-25	gastrin releasing peptide receptor	Homo sapiens	164-198
19617312-2	2009	NO is produced by endothelial NO synthase (eNOS) in the pulmonary vascular endothelium using l-arginine as a substrate and producing l-citrulline as a byproduct.	Arginine	93-103	nitric oxide synthase 3	Homo sapiens	43-47
19617312-3	2009	l-Citrulline is metabolized to l-arginine by two enzymes that are colocated with eNOS in pulmonary vascular endothelial cells.	Arginine	31-41	nitric oxide synthase 3	Homo sapiens	81-85
19497976-8	2009	As expected, physiological doses of l-T(4) normalized serum TSH, brain D2, and liver D1 in Wt mice but not the Mct8KO mice.	Arginine	36-38	deiodinase, iodothyronine, type I	Mus musculus	85-87
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Arginine	22-25	gastrin releasing peptide receptor	Homo sapiens	200-204
21475903-4	2009	Polymorphisms of TP53 include codon 72 containing either arginine (CGC) or proline (CCC).	Arginine	57-65	tumor protein p53	Homo sapiens	17-21
19617392-1	2009	Here we report the characterization of the Chlamydomonas reinhardtii gene ARG9, encoding the plastid resident N-acetyl ornithine aminotransferase, which is involved in arginine synthesis.	Arginine	168-176	uncharacterized protein	Chlamydomonas reinhardtii	74-78
19617392-2	2009	Integration of an engineered ARG9 cassette in the plastid chromosome of the nuclear arg9 mutant restores arginine prototrophy.	Arginine	105-113	uncharacterized protein	Chlamydomonas reinhardtii	29-33
19617392-2	2009	Integration of an engineered ARG9 cassette in the plastid chromosome of the nuclear arg9 mutant restores arginine prototrophy.	Arginine	105-113	uncharacterized protein	Chlamydomonas reinhardtii	84-88
19465072-4	2009	Effectiveness of the Pas segment in the intracellular delivery of bioactive peptides using arginine-rich CPPs was exemplified through the enhanced growth inhibition activity of the malignant glioma cells by a retro-inverso peptide derived from the p53 C-terminal 22-amino-acid segment (positions 361-382).	Arginine	91-99	tumor protein p53	Homo sapiens	248-251
19459759-6	2009	More than 2 years later, a subgroup of patients was re-evaluated using dynamic testing with ACTH and GHRH-arginine tests.	Arginine	106-114	growth hormone releasing hormone	Homo sapiens	101-105
19809994-1	2009	BACKGROUND: Asymmetric dimethylarginine (ADMA)is an endogenous amino acid similar to l-arginine and able to inhibit the enzyme endothelial nitric oxide synthase (eNOS).	Arginine	85-95	nitric oxide synthase 3	Homo sapiens	127-160
19592054-0	2009	Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass.	Arginine	5-15	insulin	Homo sapiens	78-85
19592054-1	2009	It is known that L-arginine treatment can ameliorate endothelial dysfunction and insulin sensitivity in type 2 diabetes mellitus patients, but little is known on L-arginine effects on these variables in nondiabetic patients with stable cardiovascular disease (coronary artery disease).	Arginine	17-27	insulin	Homo sapiens	81-88
19592054-7	2009	Finally, L-arginine increased insulin sensitivity index (P &lt; .05) and adiponectin (P &lt; .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels.	Arginine	9-19	insulin	Homo sapiens	30-37
19592054-7	2009	Finally, L-arginine increased insulin sensitivity index (P &lt; .05) and adiponectin (P &lt; .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels.	Arginine	9-19	adiponectin, C1Q and collagen domain containing	Homo sapiens	73-84
19592054-7	2009	Finally, L-arginine increased insulin sensitivity index (P &lt; .05) and adiponectin (P &lt; .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels.	Arginine	9-19	interleukin 6	Homo sapiens	112-125
19544385-11	2009	Increasing L-arginine availability via increased CAT1 expression or by supplementation improves myocardial responses to I-R.	Arginine	11-21	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	49-53
19657586-4	2009	We observed that carrying the Pro/Pro genotype of P53 Arg72Pro was a risk factor with respect to the Pro/Arg + Arg/Arg genotypes [Odds Ratio (OR) = 2.02; 95% Confidence Interval (CI) 1.02-4.00; p = 0.047].	Arginine	54-57	tumor protein p53	Homo sapiens	50-53
19657586-4	2009	We observed that carrying the Pro/Pro genotype of P53 Arg72Pro was a risk factor with respect to the Pro/Arg + Arg/Arg genotypes [Odds Ratio (OR) = 2.02; 95% Confidence Interval (CI) 1.02-4.00; p = 0.047].	Arginine	105-108	tumor protein p53	Homo sapiens	50-53
19657586-4	2009	We observed that carrying the Pro/Pro genotype of P53 Arg72Pro was a risk factor with respect to the Pro/Arg + Arg/Arg genotypes [Odds Ratio (OR) = 2.02; 95% Confidence Interval (CI) 1.02-4.00; p = 0.047].	Arginine	105-108	tumor protein p53	Homo sapiens	50-53
19706734-2	2009	The Ser(88)-Arg-Ser-Arg-Tyr(92) is the minimum chemotactic sequence of uPAR required to induce the same intracellular signaling as its ligand uPA.	Arginine	12-15	plasminogen activator, urokinase	Homo sapiens	71-74
19954613-7	2009	(3) There was a missense mutation 5797 C--&gt;T in the exon 40 of MYH9 gene which led to Arg changing into termination codon (Arg1933 stop).	Arginine	89-92	myosin heavy chain 9	Homo sapiens	66-70
20716909-0	2009	Oral administration of L-arginine in patients with angina or following myocardial infarction may be protective by increasing plasma superoxide dismutase and total thiols with reduction in serum cholesterol and xanthine oxidase.	Arginine	23-33	superoxide dismutase 1	Homo sapiens	132-152
20716909-3	2009	L-arginine has antioxidant and antiapoptotic properties, decreases endothelin-1 expression and improves endothelial function, thereby controlling oxidative injury caused during myocardial ischemic syndrome.	Arginine	0-10	endothelin 1	Homo sapiens	67-79
20716909-6	2009	We have observed that L-arginine administration (three grams per day for 15 days) resulted in increased activity of free radical scavenging enzyme superoxide dismutase (SOD) and increase in the levels of total thiols (T-SH) and ascorbic acid with concomitant decrease in lipid per-oxidation, carbonyl content, serum cholesterol and the activity of proxidant enzyme, xanthine oxidase (XO).	Arginine	22-32	superoxide dismutase 1	Homo sapiens	147-167
20716909-6	2009	We have observed that L-arginine administration (three grams per day for 15 days) resulted in increased activity of free radical scavenging enzyme superoxide dismutase (SOD) and increase in the levels of total thiols (T-SH) and ascorbic acid with concomitant decrease in lipid per-oxidation, carbonyl content, serum cholesterol and the activity of proxidant enzyme, xanthine oxidase (XO).	Arginine	22-32	superoxide dismutase 1	Homo sapiens	169-172
19397901-14	2009	The data presented herein indicate that GA causes post-translational modification of lysine and arginine residues, which are central to many events involving fibrinogen to fibrin conversion, as well as to fibrinolysis.	Arginine	96-104	fibrinogen beta chain	Homo sapiens	158-168
19688040-7	2009	CAPN10 SNP-43 and SNP-44 were genotyped and related to gene expression and insulin release in response to glucose, arginine and glibenclamide.	Arginine	115-123	calpain 10	Homo sapiens	0-6
19688040-9	2009	Moreover, the calpain-10 expression correlated positively with arginine-stimulated insulin release in islets from non-diabetic donors (r = 0.45, P = 0.015).	Arginine	63-71	calpain 10	Homo sapiens	14-24
19688040-9	2009	Moreover, the calpain-10 expression correlated positively with arginine-stimulated insulin release in islets from non-diabetic donors (r = 0.45, P = 0.015).	Arginine	63-71	insulin	Homo sapiens	83-90
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	93-96	coagulation factor II, thrombin	Homo sapiens	14-22
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	105-108	coagulation factor II, thrombin	Homo sapiens	14-22
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	105-108	coagulation factor II, thrombin	Homo sapiens	14-22
19589778-6	2009	Kinetic analyses revealed differential contributions toward the functional activity of Hgt1p by these residues and identified Asn-124 in transmembrane domain 1 (TMD1), Gln-222 in TMD4, Gln-526 in TMD9, and Glu-544, Arg-554, and Lys-562 in the intracellular loop region 537-568 containing the highly conserved proline-rich motif to be essential for the transport activity of the protein.	Arginine	215-218	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	87-92
19232413-6	2009	All patients were genotyped for a frequent functional variant at position 131 of the mature FcgammaRIIa, where the arginine (R) allele results in an increased signal transduction upon CRP binding.	Arginine	115-123	C-reactive protein	Homo sapiens	184-187
19555118-8	2009	Analysis of the arrestin2 structure reveals that Arg-7, Lys-10, and Lys-11 are in close proximity to Glu-389 and Asp-390, suggesting that these residues may form intramolecular interactions.	Arginine	49-52	arrestin beta 1	Homo sapiens	16-25
19492277-2	2009	The most important endothelial factor is nitric oxide (NO), which is formed from l-arginine with the help of NO synthase (NOS).	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	109-120
19589339-0	2009	Selective arginines are important for the antibacterial activity and host cell interaction of human alpha-defensin 5.	Arginine	10-19	defensin alpha 5	Homo sapiens	106-116
19509104-1	2009	CONTEXT: The use of the combined GHRH and arginine (GHRH-ARG) test has gained increasing acceptance in the United States as a reliable alternative test to the insulin tolerance test (ITT) for diagnosing adult GH deficiency (GHD).	Arginine	42-50	growth hormone releasing hormone	Homo sapiens	52-56
19577933-0	2009	Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.	Arginine	73-76	prepronociceptin	Homo sapiens	101-111
19577933-0	2009	Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.	Arginine	88-91	prepronociceptin	Homo sapiens	101-111
19435823-8	2009	A GHRH-arginine stimulation test was performed.	Arginine	7-15	growth hormone releasing hormone	Homo sapiens	2-6
19509104-3	2009	In this article, we review the existing published data and consensus guidelines and provide recommendations for alternative stimulation tests to the GHRH-ARG test.	Arginine	154-157	growth hormone releasing hormone	Homo sapiens	149-153
19509104-5	2009	EVIDENCE SYNTHESIS: Previous consensus guidelines and previous data assessing the reliability and discriminatory value of the GHRH-ARG, glucagon, ARG, and GH secretagogues on assessing GH reserve are discussed.	Arginine	131-134	growth hormone releasing hormone	Homo sapiens	126-130
19625214-11	2009	Null results were noted in studies with sound epidemiological design and conduct (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes), and studies in which TP53 genotype was determined from white blood cells (1.06 [0.87-1.29] for arginine homozygotes compared with heterozygotes).	Arginine	103-111	tumor protein p53	Homo sapiens	175-179
19523975-9	2009	In particular, our results indicate that Pro/Pro genotype plays a pivotal role in determining PAI-1 levels in aged subjects, while in Arg carriers PAI-1 levels are associated to the known insulin related determinants.	Arginine	134-137	insulin	Homo sapiens	188-195
19464298-3	2009	We show here that many of the key elements of this highly unusual strategy are conserved between yeast and human Rev1, including the eviction of template G from the DNA helix and the pairing of incoming deoxycytidine 5"-triphosphate with a surrogate arginine residue.	Arginine	250-258	REV1 DNA directed polymerase	Homo sapiens	113-117
19597544-3	2009	The high arginase activity causes local depletion of L-arginine, which impairs the capacity of T cells in the lesion to proliferate and to produce interferon-gamma, while T cells in the local draining lymph nodes respond normally.	Arginine	53-63	interferon gamma	Homo sapiens	147-163
19523887-0	2009	Refolding of scFv mini-antibodies using size-exclusion chromatography via arginine solution layer.	Arginine	74-82	immunglobulin heavy chain variable region	Homo sapiens	13-17
19420114-2	2009	We aimed to explore whether aging alters glomerular arginine uptake by CAT-1, the selective arginine supplier to eNOS in rats.	Arginine	52-60	GIT ArfGAP 1	Rattus norvegicus	71-76
19422794-4	2009	Converting the SUMO acceptor lysine residue to arginine residue significantly attenuated calpain-2 activity, correlating well with a loss of calpain-2-elicited cell motility.	Arginine	47-55	calpain 2	Homo sapiens	89-98
19422794-4	2009	Converting the SUMO acceptor lysine residue to arginine residue significantly attenuated calpain-2 activity, correlating well with a loss of calpain-2-elicited cell motility.	Arginine	47-55	calpain 2	Homo sapiens	141-150
19427829-0	2009	Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice.	Arginine	29-39	superoxide dismutase 1, soluble	Mus musculus	68-72
19575800-2	2009	Availability of the non-essential amino acid arginine in the inflamed airway mucosa of patients with asthma is reduced markedly, but it is not known whether this can also lead to an exaggerated production of IL-6 and IL-8.	Arginine	45-53	C-X-C motif chemokine ligand 8	Homo sapiens	217-221
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	interleukin 6	Homo sapiens	97-101
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	tumor necrosis factor	Homo sapiens	142-151
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	interleukin 6	Homo sapiens	160-164
19575800-7	2009	RESULTS: For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha-induced IL-6 and IL-8 production.	Arginine	47-55	C-X-C motif chemokine ligand 8	Homo sapiens	169-173
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	Arginine	7-15	interleukin 6	Homo sapiens	46-50
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	Arginine	7-15	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19420114-2	2009	We aimed to explore whether aging alters glomerular arginine uptake by CAT-1, the selective arginine supplier to eNOS in rats.	Arginine	92-100	GIT ArfGAP 1	Rattus norvegicus	71-76
19420114-11	2009	In conclusion, attenuated glomerular arginine transport by CAT-1 contributes to the age-dependent, NO-deficient state in old male rats through upregulation of PKCalpha.	Arginine	37-45	GIT ArfGAP 1	Rattus norvegicus	59-64
19300994-6	2009	An ArgR-derivative carrying a carboxy-terminal His-tag was made and this was demonstrated to localize even in an E. coli mutant devoid of the twin-arginine translocation (Tat) pathway in the periplasm.	Arginine	147-155	arginine repressor	Escherichia coli	3-7
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	203-206	tumor protein p53	Homo sapiens	31-34
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	203-206	tumor protein p53	Homo sapiens	48-51
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	203-206	tumor protein p53	Homo sapiens	48-51
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	207-210	tumor protein p53	Homo sapiens	31-34
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	207-210	tumor protein p53	Homo sapiens	48-51
19434453-8	2009	Notably, stage I patients with p53 mutation and p53 codon 72 Pro/Pro genotype experienced a 2.66-fold hazard ratio (95% CI 1.21-5.85) for overall survival when compared with those with p53 wild-type and Arg/Arg genotype.	Arginine	207-210	tumor protein p53	Homo sapiens	48-51
18712273-4	2009	Dietary supplementation with 0.8% arginine increased the numbers of white blood cells and granulocytes, and gene expression of interleukin (IL)-8 in spleen.	Arginine	34-42	C-X-C motif chemokine ligand 8	Homo sapiens	127-145
18712273-5	2009	On Day 14, compared with control piglets, granulocyte numbers were greater but lymphocyte numbers were lower in piglets supplemented with 0.2 and 0.4% arginine, whereas splenic expression of IL-8 and tumor necrosis factor-alpha genes was increased in piglets supplemented with 0.8% arginine.	Arginine	151-159	C-X-C motif chemokine ligand 8	Homo sapiens	191-227
18712273-5	2009	On Day 14, compared with control piglets, granulocyte numbers were greater but lymphocyte numbers were lower in piglets supplemented with 0.2 and 0.4% arginine, whereas splenic expression of IL-8 and tumor necrosis factor-alpha genes was increased in piglets supplemented with 0.8% arginine.	Arginine	282-290	C-X-C motif chemokine ligand 8	Homo sapiens	191-227
19275932-6	2009	Moreover, PDGFR-beta phosphorylates Arg on two additional unique sites whose function is unknown.	Arginine	36-39	platelet derived growth factor receptor beta	Homo sapiens	10-20
19298791-0	2009	Response of blood vessels in vitro to hyperbaric oxygen (HBO): modulation of VEGF and NO(x) release by external lactate or arginine.	Arginine	123-131	vascular endothelial growth factor A	Homo sapiens	77-81
19406100-0	2009	Arginine 383 is a crucial residue in ABCG2 biogenesis.	Arginine	0-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	37-42
19406100-10	2009	In conclusion, arginine 383 is a crucial residue for ABCG2 biogenesis, where even the most conservative mutations have a large impact.	Arginine	15-23	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-58
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Arginine	13-16	tumor protein p53	Homo sapiens	46-50
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Arginine	170-173	tumor protein p53	Homo sapiens	46-50
19052714-4	2009	RESULTS: The Arg/Pro and Pro/Pro genotypes of TP53 codon 72 were significantly correlated with a lower response rate to the combination chemotherapy when compared to the Arg/Arg genotype (35.7 vs. 66.7%, P-value 0.019) in a logistic regression analysis.	Arginine	170-173	tumor protein p53	Homo sapiens	46-50
19052714-5	2009	A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different.	Arginine	100-103	tumor protein p53	Homo sapiens	133-137
19052714-5	2009	A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different.	Arginine	188-191	tumor protein p53	Homo sapiens	133-137
19052714-5	2009	A multivariate survival analysis also showed that the time to progression for the patients with the Arg/Pro and Pro/Pro genotypes of TP53 codon 72 was worse than for the patients with the Arg/Arg genotype (Hazard ratio = 3.056, P-value = 0.047), whereas the overall survival was not significantly different.	Arginine	188-191	tumor protein p53	Homo sapiens	133-137
19366847-9	2009	Peak GH levels after GHRH-arginine stimulation levels were inversely associated with QoL-AGHDA scale scores (R = -0.53; P = 0.0005) and the Symptom Questionnaire Depression subscale scores (R = -0.35; P = 0.031) and positively associated with most SF-36 subscale scores.	Arginine	26-34	growth hormone releasing hormone	Homo sapiens	21-25
19828096-4	2009	Inducible nitric oxide synthase (iNOS) represents one of the three isoforms that produce nitric oxide using L-arginine as a substrate in response to an increase in superoxide anion activated by NF-kappaB.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	0-31
19828096-4	2009	Inducible nitric oxide synthase (iNOS) represents one of the three isoforms that produce nitric oxide using L-arginine as a substrate in response to an increase in superoxide anion activated by NF-kappaB.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	33-37
19308350-7	2009	The SNP rs2237897 was associated with both acute insulin and C-peptide response after arginine stimulation in a subgroup of cases (p = 0.0471 and p = 0.0156, respectively).	Arginine	86-94	insulin	Homo sapiens	61-70
19302302-8	2009	SIGNIFICANCE AND IMPACT OF THE STUDY: A possible biotechnological advantage of a gap1 mutant is its scarce consumption of arginine, whose metabolism has been related to the production of the carcinogenic ethyl carbamate.	Arginine	122-130	amino acid permease GAP1	Saccharomyces cerevisiae S288C	81-85
19318685-8	2009	Thus, both the loss of the arginine and its replacement by a cysteine contribute to the altered properties of apoA-I(M).	Arginine	27-35	apolipoprotein A1	Homo sapiens	110-116
19542469-1	2009	Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain.	Arginine	195-203	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	75-101
19542469-1	2009	Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain.	Arginine	195-203	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	103-110
19318685-9	2009	The arginine is potentially involved in an intrahelical salt bridge with E169 that is disrupted by the loss of the positively charged arginine and repelled by the cysteine, destabilizing the helix bundle domain in the apoA-I molecule and modifying its lipid binding characteristics.	Arginine	4-12	apolipoprotein A1	Homo sapiens	218-224
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Arginine	78-81	fibronectin 1	Homo sapiens	121-123
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Arginine	78-81	epidermal growth factor receptor	Homo sapiens	162-194
19815948-10	2009	L-arginine supplementation (0.15 mg/ml) through drinking water until eight weeks after alloxan injection significantly ameliorated the oxidative stress, as evidenced by lower MDA levels as well as higher levels of endogenous GSH, SOD, and CAT (p &lt; 0.001).	Arginine	0-10	catalase	Rattus norvegicus	239-242
19420140-5	2009	Specific multiple arginines (R) arranged in an R-based motif, RRXXXXR necessary for ER targeting, were found in the cytoplasmic tail of M1-SAT-I, and in vivo GM3 biosynthesis by M1-SAT-I was very low because of restricted transport to the Golgi apparatus.	Arginine	18-27	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	139-144
19420140-5	2009	Specific multiple arginines (R) arranged in an R-based motif, RRXXXXR necessary for ER targeting, were found in the cytoplasmic tail of M1-SAT-I, and in vivo GM3 biosynthesis by M1-SAT-I was very low because of restricted transport to the Golgi apparatus.	Arginine	18-27	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	181-186
19501907-11	2009	Thus, IUGR- and hypoxia-reduced l-arginine transport could result from increased PKCalpha, but reduced eNOS activity leading to a lower hCAT-1 expression in HUVEC.	Arginine	32-42	protein kinase C alpha	Homo sapiens	81-89
19501907-11	2009	Thus, IUGR- and hypoxia-reduced l-arginine transport could result from increased PKCalpha, but reduced eNOS activity leading to a lower hCAT-1 expression in HUVEC.	Arginine	32-42	nitric oxide synthase 3	Homo sapiens	103-107
19636175-11	2009	CONCLUSION: Thus, it may be concluded that L-arginine afforded significant protection from necrosis and apoptosis in I/R injury by upregulated Bcl-2 gene and nitric oxide production.	Arginine	43-53	BCL2, apoptosis regulator	Rattus norvegicus	143-148
19556165-5	2009	Since l-arginine is the substrate for both iNOS and arginase, and IL-4 increases arginase activity by inducing its production, a plausible mechanism of IL-4 inhibition of NO expression is via depletion of l-arginine through increased arginase activity.	Arginine	6-16	nitric oxide synthase 2, inducible	Mus musculus	43-47
19777799-8	2009	The insulin concentration was also higher in the arginine group as compared to that in the placebo group at the 30-min recovery point.	Arginine	49-57	insulin	Homo sapiens	4-11
19777799-10	2009	The results indicated that arginine supplementation during the exercise recovery period could increase glucose and insulin concentrations, and decrease FFA availability in the blood.	Arginine	27-35	insulin	Homo sapiens	115-122
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Arginine	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-77
19400587-3	2009	In Stx1 B, the corresponding (spatially) residue is Arg.	Arginine	52-55	syntaxin 1B	Homo sapiens	3-9
19356730-6	2009	The effect of vasopressin was completely blocked by pretreatment with the vasopressin V(1A) receptor antagonist d(CH2)5Tyr(Me)(2),Arg(8)-vasopressin.	Arginine	130-133	arginine vasopressin	Rattus norvegicus	14-25
19356730-6	2009	The effect of vasopressin was completely blocked by pretreatment with the vasopressin V(1A) receptor antagonist d(CH2)5Tyr(Me)(2),Arg(8)-vasopressin.	Arginine	130-133	arginine vasopressin	Rattus norvegicus	74-85
19470478-3	2009	The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients.	Arginine	114-122	tumor protein p53	Homo sapiens	4-7
19470478-3	2009	The p53 allele encoding proline at codon 72 (P72) was found to be significantly enriched over the allele encoding arginine (R72) among in vitro fertilization (IVF) patients.	Arginine	114-122	DEAD-box helicase 17	Homo sapiens	45-48
19523899-5	2009	Crystal structures of both Gab2 epitopes complexed with Grb2SH3C reveal that Gab2b contains a 3(10) helix that positions the arginine and lysine of the core-binding motif RxxK in parallel orientation.	Arginine	125-133	GRB2 associated binding protein 2	Homo sapiens	27-31
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Arginine	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
19435302-1	2009	The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP).	Arginine	28-31	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
19129013-5	2009	In this study, we hypothesized that PES surfaces modified with a peptide sequence based from fibronectin, such as Arg-Gly-Asp (RGD), Arg-Gly-Asp-Ser and Gly-Arg-Gly-Asp-Ser, would increase ASC adhesion compared to unmodified PES surfaces.	Arginine	114-117	fibronectin 1	Homo sapiens	93-104
19254751-5	2009	Mutation of the central arginine (R90) in a surface exposed cationic RRK motif unique to NDPK-D strongly reduced phospholipid interaction in vitro and in vivo.	Arginine	24-32	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	89-95
19010468-9	2009	Also, the plasma level of NO(x), L-arginine, and L-arginine/ADMA ratio were lower in patients with CSX than they were in the control group subjects.	Arginine	33-43	NK2 homeobox 5	Homo sapiens	99-102
19010468-9	2009	Also, the plasma level of NO(x), L-arginine, and L-arginine/ADMA ratio were lower in patients with CSX than they were in the control group subjects.	Arginine	49-59	NK2 homeobox 5	Homo sapiens	99-102
19494718-7	2009	L-arginine supplementation prevented the diabetes-induced reduction of BMD and osteocalcin, and the increase of RatLaps.	Arginine	0-10	bone gamma-carboxyglutamate protein	Rattus norvegicus	79-90
19490210-2	2009	Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired endothelial function in diabetes, probably due to polymorphisms in eNOS gene.	Arginine	38-48	nitric oxide synthase 3	Homo sapiens	77-81
19490210-2	2009	Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS), and earlier studies have provided evidence for altered NO metabolism and impaired endothelial function in diabetes, probably due to polymorphisms in eNOS gene.	Arginine	38-48	nitric oxide synthase 3	Homo sapiens	233-237
19513607-4	2009	The results showed that incubation of 293-eNOS cells with simvastatin (10 microm/L) for 2 h significantly increased in the activity of eNOS as shown by the conversion of L-arginine to L-citrulline (2889.70+/-201.51 versus 5630.18+/-218.75 pmol/min .	Arginine	170-180	nitric oxide synthase 3	Homo sapiens	42-46
19513607-4	2009	The results showed that incubation of 293-eNOS cells with simvastatin (10 microm/L) for 2 h significantly increased in the activity of eNOS as shown by the conversion of L-arginine to L-citrulline (2889.70+/-201.51 versus 5630.18+/-218.75 pmol/min .	Arginine	170-180	nitric oxide synthase 3	Homo sapiens	135-139
19465913-4	2009	Complex formation is promoted by the recognition of symmetrically dimethylated arginines at the N terminus of Mili by the tudor domains of Tdrd1.	Arginine	79-88	piwi-like RNA-mediated gene silencing 2	Mus musculus	110-114
18268501-0	2009	Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders.	Arginine	88-96	purinergic receptor P2X 7	Homo sapiens	104-109
18268501-6	2009	The effect of the polymorphism is non-conservative and results in a glutamine to arginine change (Gln460Arg), which is likely to affect P2RX7 dimerization and protein-protein interactions.	Arginine	81-89	purinergic receptor P2X 7	Homo sapiens	136-141
19460296-6	2009	Furthermore, the mto1 strains exhibited a marked reduction in the aminoacylation levels of mitochondrial tRNA(Lys), tRNA(Leu), tRNA(Arg) but almost no effect in those of tRNA(His).	Arginine	132-135	tRNA modification protein MTO1	Saccharomyces cerevisiae S288C	17-21
19255877-2	2009	Here, we examine the response of arginine mutants of P2X7 to soluble and covalently bound ligands.	Arginine	33-41	purinergic receptor P2X 7	Homo sapiens	53-57
19339032-4	2009	Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro.	Arginine	43-51	nucleosome assembly protein 1 like 1	Homo sapiens	0-4
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Arginine	231-234	lactoperoxidase	Homo sapiens	85-88
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Arginine	231-234	myeloperoxidase	Homo sapiens	144-147
19339248-7	2009	The site corresponding to the positions of Gln(423), Phe(422) oxygen, and Wat(6)" in LPO is occupied primarily by the side chain of Phe(407) in MPO due to an entirely different conformation of the loop corresponding to the segment Arg(418)-Phe(431) of LPO.	Arginine	231-234	lactoperoxidase	Homo sapiens	252-255
19309309-6	2009	A GST (glutathione transferase) pulldown assay using different deletion mutants revealed that the RGG (Arg-Gly-Gly) region of RHA was responsible for the interaction with beta-actin, and this dominant-negative mutant reduced the recruitment of Pol II (RNA polymerase II) into PICs.	Arginine	103-106	DExH-box helicase 9	Homo sapiens	126-129
19451596-7	2009	Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66).	Arginine	27-30	tumor protein p53	Homo sapiens	22-26
20540537-1	2009	Radiolabeled RGD (Arg-Gly-Asp) and bombesin (BBN) radiotracers that specifically target integrin alpha(v)beta(3) and gastrin releasing peptide receptor (GRPR) are both promising radiopharmaceuticals for tumor imaging.	Arginine	18-21	gastrin releasing peptide receptor	Homo sapiens	117-151
19451596-7	2009	Subjects carrying the TP53 Arg72Pro polymorphism were found to have a significantly increased death risk (Pro/Pro versus Arg/Arg; hazard ratio, 2.90; 95% CI, 1.28-6.66).	Arginine	121-124	tumor protein p53	Homo sapiens	22-26
19451596-8	2009	In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11).	Arginine	58-61	tumor protein p53	Homo sapiens	53-57
19451596-8	2009	In the subgroup of 130 high-grade osteosarcomas, the TP53 Arg72Pro was an independent marker of EFS (Pro/Pro versus Arg/Arg; hazard ratio, 2.67; 95% CI, 1.17-6.11).	Arginine	116-119	tumor protein p53	Homo sapiens	53-57
20641376-11	2004	To improve the tumor/kidney uptake ratio and metabolic stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	128-131	proopiomelanocortin	Homo sapiens	85-94
20641376-11	2004	To improve the tumor/kidney uptake ratio and metabolic stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	160-163	proopiomelanocortin	Homo sapiens	85-94
20641610-11	2004	To improve the tumor/kidney uptake ratio and metabolic stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (CBTE2A).	Arginine	128-131	proopiomelanocortin	Homo sapiens	85-94
20641610-11	2004	To improve the tumor/kidney uptake ratio and metabolic stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (CBTE2A).	Arginine	160-163	proopiomelanocortin	Homo sapiens	85-94
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	fatty acid binding protein 1	Rattus norvegicus	57-85
19281183-3	2009	Cc2672 was shown to catalyze the hydrolysis of l-Xaa-l-Arg/Lys dipeptides and the N-acetyl and N-formyl derivatives of lysine and arginine.	Arginine	130-138	Xaa-Pro dipeptidase	Caulobacter vibrioides CB15	0-6
19414610-2	2009	In this study, we show that interactions between Arg and the Arp2/3 complex regulator cortactin are essential to mediate actin-based cell edge protrusion during fibroblast adhesion to fibronectin.	Arginine	49-52	fibronectin 1	Homo sapiens	184-195
19130170-3	2009	In addition, glutamine and arginine stimulate the mitogen-activated protein kinase and mammalian target of rapamycin (mTOR)/p70 (s6) kinase pathways, respectively, to enhance mucosal cell migration and restitution.	Arginine	27-35	mechanistic target of rapamycin kinase	Homo sapiens	87-116
19130170-3	2009	In addition, glutamine and arginine stimulate the mitogen-activated protein kinase and mammalian target of rapamycin (mTOR)/p70 (s6) kinase pathways, respectively, to enhance mucosal cell migration and restitution.	Arginine	27-35	mechanistic target of rapamycin kinase	Homo sapiens	118-122
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	lipase C, hepatic type	Rattus norvegicus	144-158
19555809-9	2009	In addition, we found simvastatin-induced increases in aspartate transaminase and fibrinogen to be attenuated by L-arginine as compared to placebo.	Arginine	113-123	fibrinogen beta chain	Homo sapiens	82-92
19292763-7	2009	This is a novel epitope, because the clone responds to proinsulin but not to insulin, T cell recognition requires the last two residues of the C-peptide (Lys, Arg) and recognition does not depend upon a vicinal disulphide bond between the A6 and A7 cysteines.	Arginine	159-162	insulin	Homo sapiens	58-65
19116343-3	2009	In addition to impaired glucose tolerance, adult heterozygous mutant mice (Pax6(m/+)) secreted less insulin responding to glucose and arginine administration compared with control mice.	Arginine	134-142	paired box 6	Mus musculus	75-79
19366727-4	2009	Using polysome analysis and RNA-binding assays, we show that elevated levels of translation depend on an interaction between a triple arginine motif in LC3 and the AU-rich element in Fn1 mRNA.	Arginine	134-142	fibronectin 1	Homo sapiens	183-186
19055368-0	2009	VEGF siRNA delivery system using arginine-grafted bioreducible poly(disulfide amine).	Arginine	33-41	vascular endothelial growth factor A	Homo sapiens	0-4
19383811-7	2009	p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P &lt; 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg).	Arginine	230-233	tumor protein p53	Homo sapiens	0-3
19383811-7	2009	p53 Pro/Pro was strongly associated with shorter survival in the entire cohort (MS of 11.8 versus 29.1 months, P &lt; 0.0001; adjusted hazard ratio for death, 2.05; 95% confidence interval, 1.30-3.24; P = 0.002 for Pro/Pro versus Arg/Arg).	Arginine	234-237	tumor protein p53	Homo sapiens	0-3
19196887-7	2009	RESULTS: Treatment-induced change in combined glucose- and arginine-stimulated C-peptide secretion was 2.46-fold (95% CI 2.09-2.90, P &lt; 0.0001) greater after a 52-week exenatide treatment compared with insulin glargine treatment.	Arginine	59-67	insulin	Homo sapiens	205-212
19273602-6	2009	Combined lysine-to-arginine mutations on the acetylation sites, with no effects on Nrf2 protein stability, compromised the DNA-binding activity of Nrf2 in a promoter-specific manner.	Arginine	19-27	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
19153083-3	2009	Asp(26) and Asp(29) in the N-terminal domain of betaarrestin1 are critical for its binding to MEK1, whereas Arg(47) and Arg(49) in the N-terminal domain of MEK1 are critical for its binding to betaarrestin1.	Arginine	108-111	arrestin beta 1	Homo sapiens	48-61
19153083-3	2009	Asp(26) and Asp(29) in the N-terminal domain of betaarrestin1 are critical for its binding to MEK1, whereas Arg(47) and Arg(49) in the N-terminal domain of MEK1 are critical for its binding to betaarrestin1.	Arginine	120-123	arrestin beta 1	Homo sapiens	48-61
19240027-0	2009	Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII.	Arginine	12-15	coagulation factor II, thrombin	Homo sapiens	61-69
19118899-5	2009	Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1.	Arginine	44-52	karyopherin subunit alpha 1	Homo sapiens	18-23
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	109-112	coagulation factor II, thrombin	Homo sapiens	46-54
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	118-121	coagulation factor II, thrombin	Homo sapiens	46-54
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	118-121	coagulation factor II, thrombin	Homo sapiens	46-54
19240027-2	2009	The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 or Arg-372 and influences reaction rates at these sites.	Arginine	50-53	coagulation factor II, thrombin	Homo sapiens	29-37
19240027-2	2009	The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 or Arg-372 and influences reaction rates at these sites.	Arginine	84-87	coagulation factor II, thrombin	Homo sapiens	29-37
19240027-2	2009	The catalytic efficiency for thrombin cleavage at Arg-740 is greater than at either Arg-1689 or Arg-372 and influences reaction rates at these sites.	Arginine	84-87	coagulation factor II, thrombin	Homo sapiens	29-37
19240027-6	2009	Thrombin activation of the R1689H variant showed an approximately 340-fold reduction in the rate of Arg-1689 cleavage, whereas the R1689Q variant was resistant to thrombin cleavage at this site.	Arginine	100-103	coagulation factor II, thrombin	Homo sapiens	0-8
19260709-3	2009	Prior studies on protein tyrosine kinases Csk and Src revealed the potential for chemical rescue of catalytically deficient mutant kinases (Arg to Ala mutations) by small diamino compounds, particularly imidazole; however, the potency and efficiency of rescue was greater for Src.	Arginine	140-143	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-53
19441602-8	2009	A significant difference of IgE serum levels was observed among polymorphisms at position 16, with the highest IgE level in the arginine/arginine group (P = .04).	Arginine	128-136	immunoglobulin heavy constant epsilon	Homo sapiens	28-31
19441602-8	2009	A significant difference of IgE serum levels was observed among polymorphisms at position 16, with the highest IgE level in the arginine/arginine group (P = .04).	Arginine	128-136	immunoglobulin heavy constant epsilon	Homo sapiens	111-114
19441602-8	2009	A significant difference of IgE serum levels was observed among polymorphisms at position 16, with the highest IgE level in the arginine/arginine group (P = .04).	Arginine	137-145	immunoglobulin heavy constant epsilon	Homo sapiens	28-31
19441602-8	2009	A significant difference of IgE serum levels was observed among polymorphisms at position 16, with the highest IgE level in the arginine/arginine group (P = .04).	Arginine	137-145	immunoglobulin heavy constant epsilon	Homo sapiens	111-114
18462472-8	2009	Multivariate analysis showed that those with TP53 codon 72 Arg/Pro allele had significantly shorter survival than those with Arg/Arg allele (hazard ratio 1.35; 95% CI = 1.07-1.71).	Arginine	59-62	tumor protein p53	Homo sapiens	45-49
19302215-5	2009	Of the four type II transmembrane serine proteases studied, matriptase-2 was the most promiscuous, and matriptase was the most discriminating, with a distinct specificity for Arg residues at P4, P3 and P2.	Arginine	175-178	exosome component 10	Homo sapiens	191-204
19168731-8	2009	Mass spectrometric analyses of IL-4 and IL-5 showed that hydrolysis by RgpA-Kgp complexes was C terminal to Arg and Lys residues of the cytokines.	Arginine	108-111	interleukin 4	Homo sapiens	31-35
19332619-9	2009	Comparison of the outer pore regions of Kv3 and Kv1.5 channels identified an Arg residue in Kv1.5 that is replaced by a Tyr in Kv3 channels.	Arginine	77-80	potassium voltage-gated channel subfamily A member 5	Homo sapiens	48-53
19332619-9	2009	Comparison of the outer pore regions of Kv3 and Kv1.5 channels identified an Arg residue in Kv1.5 that is replaced by a Tyr in Kv3 channels.	Arginine	77-80	potassium voltage-gated channel subfamily A member 5	Homo sapiens	92-97
19386107-2	2009	This model is particularly relevant to cancer cell metastasis to bone since BSP, bound to the alphavbeta3 integrin through its arginine-glycine-aspartic acid motif, could recruit MMP-2 to the cell surface.	Arginine	127-135	integrin binding sialoprotein	Homo sapiens	76-79
19176602-4	2009	Activity of NOS3 was characterized by conversion of arginine to citrulline, BH(4) intracellular availability, cGMP, and superoxide anion production.	Arginine	52-60	nitric oxide synthase 3	Homo sapiens	12-16
19243126-9	2009	In agreement, peroxymonocarbonate was docked into the hSod1 active site, where it interacted with the conserved Arg(143).	Arginine	112-115	superoxide dismutase 1	Homo sapiens	54-59
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Arginine	83-91	SUMO-targeted ubiquitin ligase complex subunit SLX8	Saccharomyces cerevisiae S288C	152-156
19170983-10	2009	Homology modeling of the JAL+ RhCE protein suggests that the Arg--&gt;Trp change eliminates a critical loop-stabilizing H-bond between the side chain of Arg114 and the e-specific amino acid Ala226.	Arginine	61-64	Rh blood group CcEe antigens	Homo sapiens	30-34
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Arginine	70-78	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	170-174
19164285-5	2009	Here we have identified the specific cleavage site, Arg(208), of a pathological TDP-43 CTF purified from FTLD-U brains and show that the expression of this and other TDP-43 CTFs in cultured cells recapitulates key features of TDP-43 proteinopathy.	Arginine	52-55	TAR DNA binding protein	Homo sapiens	80-86
19164285-5	2009	Here we have identified the specific cleavage site, Arg(208), of a pathological TDP-43 CTF purified from FTLD-U brains and show that the expression of this and other TDP-43 CTFs in cultured cells recapitulates key features of TDP-43 proteinopathy.	Arginine	52-55	TAR DNA binding protein	Homo sapiens	166-172
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Arginine	70-78	interferon gamma	Mus musculus	196-205
19000036-10	2009	Interestingly, according to the docking results, Arg(PrP)(151) (Arg(151) from prion protein) is the key residue for the interactions with D18scFv, anchoring the PrP(C) to the cavity of the antibody.	Arginine	49-52	prion protein	Homo sapiens	53-56
19046801-12	2009	Mutations of p53 determined in NHL cases (30%) were of Arg-176 (1/20: 5%), Phe-238 (1/20: 5%), Ser-249 (2/20; 10%), Lys-249 (1/20: 5%) and Phe-250 (1/20: 5%).	Arginine	55-58	tumor protein p53	Homo sapiens	13-16
19000036-10	2009	Interestingly, according to the docking results, Arg(PrP)(151) (Arg(151) from prion protein) is the key residue for the interactions with D18scFv, anchoring the PrP(C) to the cavity of the antibody.	Arginine	64-67	prion protein	Homo sapiens	53-56
19221494-0	2009	p53 methylation--the Arg-ument is clear.	Arginine	21-24	tumor protein p53	Homo sapiens	0-3
19221494-5	2009	Most recently, arginine methylation mediated by PRMT5, has been identified as an additional and important p53 modification.	Arginine	15-23	protein arginine methyltransferase 5	Homo sapiens	48-53
19221494-5	2009	Most recently, arginine methylation mediated by PRMT5, has been identified as an additional and important p53 modification.	Arginine	15-23	tumor protein p53	Homo sapiens	106-109
19221494-6	2009	DNA damage induced p53 arginine methylation impacts on the biochemical properties and functional outcome of the p53 response.	Arginine	23-31	tumor protein p53	Homo sapiens	19-22
19221494-6	2009	DNA damage induced p53 arginine methylation impacts on the biochemical properties and functional outcome of the p53 response.	Arginine	23-31	tumor protein p53	Homo sapiens	112-115
19074424-0	2009	The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.	Arginine	22-30	coagulation factor II, thrombin	Homo sapiens	103-111
18715148-2	2009	NO, a gas, is produced from L-arginine by different isoforms of nitric oxide synthase (NOS) and serves many normal physiologic purposes, such as promoting vasodilation of blood vessels and mediating communication between nervous system cells.	Arginine	28-38	nitric oxide synthase 2	Homo sapiens	64-85
19234124-6	2009	However, the His&gt;Arg change substantially decreases the stability and affinity of HLA-A2 association, consistent with the reduced immunogenicity of the HA-1(R) variant.	Arginine	20-23	Rho GTPase activating protein 45	Homo sapiens	155-159
19257898-9	2009	The most prevalent haplotype was dhfr Arg-59 with the dhps Gly-437 mutant and the dhps 540 wild type (85.5%).	Arginine	38-41	deoxyhypusine synthase	Homo sapiens	54-58
19146426-7	2009	The insulin binding region is composed of the same amino acids in amyloidogenic human IAPP and soluble rat IAPP (with the sole exception of His/Arg-18), implying the same binding mode for both hormones.	Arginine	144-147	insulin	Homo sapiens	4-11
19146426-8	2009	This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis.	Arginine	9-12	insulin	Homo sapiens	78-85
20641276-11	2004	The peptide GGSGRSANAKC was found to be an uPA substrate that is cleaved between the Arg (R) and Ser (S) residues.	Arginine	85-88	plasminogen activator, urokinase	Homo sapiens	43-46
20641276-16	2004	The NIR fluorescence signal will increase when the Arg-Ser bond is cleaved by uPA, releasing fragments containing Cy5.5.	Arginine	51-54	plasminogen activator, urokinase	Homo sapiens	78-81
19111603-10	2009	The enzymes iNOS and arginase metabolize a common substrate, l-arginine, but produce distinct biological effects.	Arginine	61-71	nitric oxide synthase 2, inducible	Mus musculus	12-16
19212663-3	2009	For p53 genotype analysis, breast cancer patients presented a significant (p&lt;0.05) over-representation of p53 Arg homozygosity (55.5%) compared with the healthy control group (33.3%).	Arginine	113-116	tumor protein p53	Homo sapiens	109-112
19212663-6	2009	It is possible that p53 Arg homozygosity is associated with breast cancer and may represent a potential risk factor for breast tumorigenesis.	Arginine	24-27	tumor protein p53	Homo sapiens	20-23
19211775-11	2009	After IC50 determination in InteraX and cytotoxicity assays, 182 novel compounds remained as potential arginine-competitive inhibitors of dimeric iNOS.	Arginine	103-111	nitric oxide synthase 2	Homo sapiens	146-150
19234205-7	2009	This was reflected by a switch in the enzymatic pathway for arginine metabolism from arginase to inducible NO synthase and the reduced expression of RELM-alpha and Ym1.	Arginine	60-68	nitric oxide synthase 2, inducible	Mus musculus	97-118
18680102-9	2009	Additionally, UO126 and ODQ inhibited the migration restoring effects of L-arginine in L-NAME-treated cells, suggesting the involvement of cGMP and MAPK pathways in NO-mediated migration.	Arginine	73-83	mitogen-activated protein kinase 3	Homo sapiens	148-152
18680102-10	2009	GSPs inhibited L-arginine and 8-Br-cGMP-induced activation of ERK1/2 in A549 cells.	Arginine	15-25	mitogen-activated protein kinase 3	Homo sapiens	62-68
19181385-6	2009	The loss of GANP caused up-regulation of phosphorylation and arginine dimethylation of STAT6 in B cells after stimulation with LPS and IL-4 in vitro.	Arginine	61-69	minichromosome maintenance complex component 3 associated protein	Mus musculus	12-16
19181385-9	2009	GANP down-regulates JAK1/JAK3 to STAT6-signaling with regulation of arginine methylation activity, which might be responsible for the B cell endogenous suppressive mechanism of hyper-IgE.	Arginine	68-76	minichromosome maintenance complex component 3 associated protein	Mus musculus	0-4
19217439-1	2009	Nitric oxide (NO) is synthesized from arginine and O(2) by nitric oxide synthase (NOS).	Arginine	38-46	nitric oxide synthase 2	Homo sapiens	59-80
19212643-1	2009	The impact of a polymorphism of the wild-type human tumour suppressor gene p53(wt) on carcinogenesis is subject of controversy ever since a higher susceptibility of p53 to HPV-E6 mediated degradation when encoding for Arginine at codon 72 (p53Arg) was first reported.	Arginine	218-226	tumor protein p53	Homo sapiens	75-78
19212643-1	2009	The impact of a polymorphism of the wild-type human tumour suppressor gene p53(wt) on carcinogenesis is subject of controversy ever since a higher susceptibility of p53 to HPV-E6 mediated degradation when encoding for Arginine at codon 72 (p53Arg) was first reported.	Arginine	218-226	tumor protein p53	Homo sapiens	165-168
19074527-1	2009	Cytochrome P450 (P450) 2B6 metabolizes a number of clinically relevant drugs and is one of the most highly polymorphic human P450 enzymes, with the Lys(262)--&gt;Arg substitution being especially common in several genetic variants.	Arginine	162-165	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26
19100624-5	2009	In confirmation of this, we detected constitutive ligand-independent internalization of C5L2 that resulted in the rapid accumulation of C5a and its stable metabolite, C5a des Arg, within the cell with only a small net change in cell surface receptor levels.	Arginine	175-178	complement C5a receptor 2	Homo sapiens	88-92
19100624-5	2009	In confirmation of this, we detected constitutive ligand-independent internalization of C5L2 that resulted in the rapid accumulation of C5a and its stable metabolite, C5a des Arg, within the cell with only a small net change in cell surface receptor levels.	Arginine	175-178	complement C5a receptor 1	Homo sapiens	167-170
19267411-7	2009	The GHRH + arginine induced GH rise in patients with del15q11-q13 was significantly higher than subjects with UPD15 (GH peak 7.7 +/- 1.7 microg/L vs. 2.7 +/- 1.0 microg/L, P &lt; 0.05; AUC 458.5 +/- 91.0 microg/L/hr vs. 134.4 +/- 46.0 microg/L/hr, P &lt; 0.02).	Arginine	11-19	growth hormone releasing hormone	Homo sapiens	4-8
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Arginine	124-132	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	221-226
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Arginine	124-132	potassium voltage-gated channel modifier subfamily G member 4	Homo sapiens	231-236
19179283-4	2009	At these positions, many other mouse lines, including DBA/2J, encode, respectively, Glu-39 and Arg-152 (ER haplotype), amino acids found also in hSERT.	Arginine	95-98	solute carrier family 6 member 4	Homo sapiens	145-150
19217391-6	2009	Additionally, they suggest that the increased affinity of Taz2 for p53(1-39) phosphorylated at Thr(18) is due in part to electrostatic interactions of the phosphate with neighboring arginine residues in Taz2.	Arginine	182-190	tumor protein p53	Homo sapiens	67-70
19146403-2	2009	We investigate the role of arginine in suppressing protein aggregation and its mechanism by using bovine serum albumin as a model system.	Arginine	27-35	albumin	Homo sapiens	111-118
19143629-4	2009	Binding of Ca(2+) to EF3 (third EF-hand) enables the side chain of Arg(125), present in the loop connecting EF3 and EF4 (fourth EF-hand), to move sufficiently to make a primary hydrophobic pocket accessible to the critical PPYP (Pro-Pro-Tyr-Pro) motif in Alix, which partially overlaps with the GPP (Gly-Pro-Pro) motif for binding to Cep55 (centrosome protein of 55 kDa).	Arginine	67-70	centrosomal protein 55	Homo sapiens	334-339
19057517-1	2009	BACKGROUND: The effects of long-term oral administration of L-arginine, a substrate for nitric oxide (NO) production, on left ventricular (LV) remodeling, myocardial function and the prevention of heart failure (HF) was compared to the angiotensin-converting enzyme (ACE) inhibitor captopril in a rat model of hypertensive HF (aged spontaneously hypertensive rat (SHR)).	Arginine	60-70	angiotensin I converting enzyme	Rattus norvegicus	236-265
19057517-1	2009	BACKGROUND: The effects of long-term oral administration of L-arginine, a substrate for nitric oxide (NO) production, on left ventricular (LV) remodeling, myocardial function and the prevention of heart failure (HF) was compared to the angiotensin-converting enzyme (ACE) inhibitor captopril in a rat model of hypertensive HF (aged spontaneously hypertensive rat (SHR)).	Arginine	60-70	angiotensin I converting enzyme	Rattus norvegicus	267-270
19071212-3	2009	Albumin, fetal cord serum ultrafiltrate, and L-arginine triggered capacitation and ROS generation (NO* and O(2)(*)(-)) and superoxide dismutase (SOD) and NOS inhibitors prevented all these effects.	Arginine	45-55	superoxide dismutase 1	Homo sapiens	145-148
19103149-5	2009	Nuclear localization of TFPI-2 required a NLS sequence located in its Lys/Arg-rich C-terminal tail comprising residues 191-211, as a TFPI-2 construct lacking the C-terminal tail failed to localize to the nucleus.	Arginine	74-77	tissue factor pathway inhibitor 2	Homo sapiens	24-30
19143629-4	2009	Binding of Ca(2+) to EF3 (third EF-hand) enables the side chain of Arg(125), present in the loop connecting EF3 and EF4 (fourth EF-hand), to move sufficiently to make a primary hydrophobic pocket accessible to the critical PPYP (Pro-Pro-Tyr-Pro) motif in Alix, which partially overlaps with the GPP (Gly-Pro-Pro) motif for binding to Cep55 (centrosome protein of 55 kDa).	Arginine	67-70	centrosomal protein 55	Homo sapiens	341-369
18996917-7	2009	In vitro assays show that M2a macrophages reduce lysis of muscle cells by M1 macrophages through the competition of arginase in M2a cells with iNOS in M1 cells for their common, enzymatic substrate, arginine.	Arginine	199-207	nitric oxide synthase 2, inducible	Mus musculus	143-147
19309283-8	2009	With regard to the second patient, a previously described transition (c.916C&gt;T) that changed an arginine to a cysteine residue (p.R306C) in TRD domain of MeCP2 protein was revealed.	Arginine	99-107	methyl-CpG binding protein 2	Homo sapiens	157-162
19098713-2	2009	Arg 125 of RelB is in contact with an additional DNA base pair.	Arginine	0-3	RELB proto-oncogene, NF-kB subunit	Homo sapiens	11-15
19081984-0	2009	Re and (99m)Tc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase.	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	105-136
18847325-4	2009	The Wnt-4 protein contains a C-terminal arginine residue and binds to CPZ through the CRD.	Arginine	40-48	Wnt family member 4	Rattus norvegicus	4-9
18847325-11	2009	Removal of the C-terminal arginine residue of Wnt-4 by site-directed mutagenesis enhances the positive effect of Wnt-4 on terminal differentiation.	Arginine	26-34	Wnt family member 4	Rattus norvegicus	46-51
18847325-11	2009	Removal of the C-terminal arginine residue of Wnt-4 by site-directed mutagenesis enhances the positive effect of Wnt-4 on terminal differentiation.	Arginine	26-34	Wnt family member 4	Rattus norvegicus	113-118
19037250-1	2009	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms.	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	45-66
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Arginine	127-130	parathyroid hormone	Rattus norvegicus	38-41
19013489-4	2009	It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats.	Arginine	127-130	parathyroid hormone	Rattus norvegicus	56-59
19013489-6	2009	The aim of the present study was to synthesize, by the solid phase peptide synthesis method, PTH fragments including the -Arg-Lys-Lys- sequence and test their influence on blood pressure and calcium plasma concentration in rats.	Arginine	122-125	parathyroid hormone	Rattus norvegicus	93-96
19013489-8	2009	The presence of strong alkali sequence -Arg-Lys-Lys- in PTH(25-30) fragment is not sufficient to induce hypertension either in physiological or pharmacological doses in rats.	Arginine	40-43	parathyroid hormone	Rattus norvegicus	56-59
19174069-2	2009	The aim of our study was to evaluate the effect of enteral nutrition supplemented with a high dose of arginine on c-reactive protein (CRP), interleukin 6 (IL6) and tumoral necrosis factor (TNF alpha) in surgical head and neck cancer patients.	Arginine	102-110	interleukin 6	Homo sapiens	140-153
19174069-2	2009	The aim of our study was to evaluate the effect of enteral nutrition supplemented with a high dose of arginine on c-reactive protein (CRP), interleukin 6 (IL6) and tumoral necrosis factor (TNF alpha) in surgical head and neck cancer patients.	Arginine	102-110	tumor necrosis factor	Homo sapiens	189-198
19019442-1	2009	The killer cell Ig-like receptor (KIR) 3DH protein in rhesus macaques (Macaca mulatta) is thought to be an activating one because it contains a charged arginine in its transmembrane domain and has a truncated cytoplasmic domain.	Arginine	152-160	killer cell immunoglobulin-like receptor, 3 domains, hybrid	Macaca mulatta	4-42
19174069-2	2009	The aim of our study was to evaluate the effect of enteral nutrition supplemented with a high dose of arginine on c-reactive protein (CRP), interleukin 6 (IL6) and tumoral necrosis factor (TNF alpha) in surgical head and neck cancer patients.	Arginine	102-110	C-reactive protein	Homo sapiens	114-132
19013433-5	2009	By introducing point mutations of these residues within the proposed binding domains, we experimentally confirmed that arginine 279, glutamic acid 246 in Smad3 and glutamic acid 1321 in Erbin are important for the binding.	Arginine	119-127	erbb2 interacting protein	Homo sapiens	186-191
19000626-5	2009	Direct sequencing of SOD1 gene revealed a heterozygous mutation in codon 22 substituting a highly conserved amino acid, from glutamine to arginine (Q22R).	Arginine	138-146	superoxide dismutase 1	Homo sapiens	21-25
19123921-6	2009	For zinc finger 2, a second arginine residue within the alpha-helix is also critical for RNA binding, while several alpha-helical residues in zinc finger 3 contribute to the overall affinity of WT1 for RNA.	Arginine	28-36	WT1 transcription factor	Homo sapiens	194-197
19081984-4	2009	The complexes bearing guanidino substituted analogues of l-arginine still present considerable inhibitory action (N(omega)-monomethyl-l-arginine, K(i) = 36 microM; N(omega)-nitro-l-arginine, K(i) = 84 microM), being the first examples of organometallic complexes able to inhibit the iNOS.	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	283-287
19319842-6	2009	Modulation of the arginine-NO pathway by BH4 and arginine is beneficial for ameliorating vascular insulin resistance in obesity and diabetes.	Arginine	18-26	insulin	Homo sapiens	98-105
19100513-5	2009	Sequence analysis of the GATA1 gene revealed a deletion-insertion mutation within the exon 2 introducing a stop codon after Arg 64.	Arginine	124-127	GATA binding protein 1	Homo sapiens	25-30
19319842-6	2009	Modulation of the arginine-NO pathway by BH4 and arginine is beneficial for ameliorating vascular insulin resistance in obesity and diabetes.	Arginine	49-57	insulin	Homo sapiens	98-105
19319842-3	2009	Recent studies have shown that reduced synthesis of nitric oxide (NO; a major vasodilator) from L-arginine in endothelial cells is a major factor contributing to the impaired action of insulin in the vasculature of obese and diabetic subjects.	Arginine	96-106	insulin	Homo sapiens	185-192
19362296-1	2009	Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	0-31
19362296-1	2009	Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	33-37
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	interferon alpha 1	Homo sapiens	281-284
19604504-7	2009	Moreover, the ARG/GAPDH expression ratio increased from DLBCL stage I towards stage VI, all showing significantly more ARG expression than FL and BL (in all cases p&lt;0.00).	Arginine	119-122	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	18-23
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Arginine	113-121	coagulation factor II, thrombin	Homo sapiens	203-211
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	interferon alpha 1	Homo sapiens	164-167
19086919-0	2009	Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5.	Arginine	60-68	fibroblast growth factor 2	Homo sapiens	0-26
19086919-0	2009	Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5.	Arginine	60-68	fibroblast growth factor 2	Homo sapiens	28-33
19086919-0	2009	Fibroblast growth factor 2 (FGF-2) is a novel substrate for arginine methylation by PRMT5.	Arginine	60-68	protein arginine methyltransferase 5	Homo sapiens	84-89
19086919-2	2009	The higher molecular mass isoforms (FGF-2(21) and (23)) contain an arginine-rich N-terminus organized in RG-motifs followed by the 18 kDa FGF-2 (FGF-2(18)) core which is common to all isoforms.	Arginine	67-75	fibroblast growth factor 2	Homo sapiens	36-41
19086919-12	2009	With regard to function, inhibition of methyltransferase activity in HEK293T cells leads to cytoplasmic enrichment of FGF-2, indicating the importance of arginine methylation for shuttling of FGF-2(23) to the nucleus.	Arginine	154-162	fibroblast growth factor 2	Homo sapiens	118-123
19086919-12	2009	With regard to function, inhibition of methyltransferase activity in HEK293T cells leads to cytoplasmic enrichment of FGF-2, indicating the importance of arginine methylation for shuttling of FGF-2(23) to the nucleus.	Arginine	154-162	fibroblast growth factor 2	Homo sapiens	192-197
18977122-3	2009	The denatured/reduced lysozyme was adsorbed onto the zeolite and the protein was refolded by desorbing it into refolding buffer, consisting of redox reagents, guanidine hydrochloride, polyethylene glycol, and L-arginine.	Arginine	209-219	lysozyme	Homo sapiens	22-30
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Arginine	113-121	coagulation factor II, thrombin	Homo sapiens	274-282
19291875-2	2009	The p53 codon 72 Arg-Pro (CGC to CCC) polymorphism of exon 4 affects various biological properties; recently, it was reported that this polymorphism affects the ability to induce apoptosis in vitro.	Arginine	17-20	tumor protein p53	Homo sapiens	4-7
19291875-10	2009	We concluded that the p53 codon 72 Arg/Pro polymorphism is not associated with glaucoma in Brazilian patients.	Arginine	35-38	tumor protein p53	Homo sapiens	22-25
19628295-0	2009	Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha.	Arginine	68-78	nitric oxide synthase 2, inducible	Mus musculus	28-49
19628295-1	2009	In mouse inflammatory macrophages the cytokine-mediated expression of inducible nitric oxide synthase (iNOS) is regulated by the availability of the substrate l-arginine.	Arginine	159-169	nitric oxide synthase 2, inducible	Mus musculus	70-101
19628295-1	2009	In mouse inflammatory macrophages the cytokine-mediated expression of inducible nitric oxide synthase (iNOS) is regulated by the availability of the substrate l-arginine.	Arginine	159-169	nitric oxide synthase 2, inducible	Mus musculus	103-107
19628295-2	2009	Following arginine starvation the levels of iNOS mRNA remain unimpaired, whereas the translation of iNOS protein is strikingly downregulated.	Arginine	10-18	nitric oxide synthase 2, inducible	Mus musculus	44-48
19628295-6	2009	From these data we conclude that l-arginine deficiency blocks the translation of iNOS and elicits a stress response in macrophages, both of which, however, do not result from an enhanced phosphorylation of eIF2alpha.	Arginine	33-43	nitric oxide synthase 2, inducible	Mus musculus	81-85
18977386-2	2009	We have determined the crystal structures of 2Mn2+, 1Rb1+ and 4Ni2+ human arg-insulin and compared them with the 2Zn2+ structure.	Arginine	74-77	insulin	Homo sapiens	78-85
18977386-3	2009	The first two structures exist in the T3R3f state like the native 2Zn2+ arg-insulin, while the 4Ni2+ adopts a T6 conformation.	Arginine	72-75	insulin	Homo sapiens	76-83
19194554-8	2009	The expression level of iNOS mRNA and its protein that was significantly increased by L-arginine was decreased by iNOS inhibitor but not by GTE.	Arginine	86-96	nitric oxide synthase 2	Homo sapiens	114-118
19636420-7	2009	Asbestosis was associated with the homozygous SOD2 - 9Ala/Ala genotype (OR = 1.50, 95% CI 1.01-2.24), whereas the association for the SOD3 Arg/Gly genotype was not significant (OR = 1.63, 95% CI 0.62-4.27).	Arginine	139-142	superoxide dismutase 3	Homo sapiens	134-138
19489187-5	2009	The study also showed that this new arginine toothpaste provided significantly greater reductions (p &lt; 0.05) in dentin hypersensitivity in response to tactile (16.2%, 22.4%, and 21.4%) and air blast (16.2%, 29.2%, and 63.4%) stimuli than the benchmark commercial toothpaste containing 2% potassium ion and 1450 ppm NaF in a silica base, after two, four, and eight weeks of product use, respectively.	Arginine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	318-321
19489188-5	2009	The study also showed that this new arginine toothpaste provided significantly greater reductions (p &lt; 0.05) in dentin hypersensitivity in response to tactile (37.0%, 30.0%, and 12.2%) and air blast (23.9%, 32.0%, and 29.3%) stimuli than the commercial sensitive toothpaste containing 2% potassium ion and 1450 ppm fluoride as NaF in a silica base, after two weeks, four weeks, and eight weeks of product use, respectively.	Arginine	36-44	C-X-C motif chemokine ligand 8	Homo sapiens	330-333
19414966-6	2009	Presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation.	Arginine	23-31	tumor protein p53	Homo sapiens	52-55
19194554-7	2009	NO production by L-arginine was significantly suppressed by GTE and iNOS inhibitor (p&lt;0.01).	Arginine	17-27	nitric oxide synthase 2	Homo sapiens	68-72
19194554-8	2009	The expression level of iNOS mRNA and its protein that was significantly increased by L-arginine was decreased by iNOS inhibitor but not by GTE.	Arginine	86-96	nitric oxide synthase 2	Homo sapiens	24-28
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Arginine	74-77	prepronociceptin	Homo sapiens	39-44
19263877-4	2009	STUDY DESIGN: In a genetic association study, PD1.5 (7785) C/T, CTLA-4 +49 A/G, and p53 codon 72 Arg/Pro SNPs were genotyped in case-control groups with patient/control ratios of 92:295, 83:84 and 85:150, respectively.	Arginine	97-100	tumor protein p53	Homo sapiens	84-87
18987134-0	2009	An arginine switch in the species B adenovirus knob determines high-affinity engagement of cellular receptor CD46.	Arginine	3-11	CD46 molecule	Homo sapiens	109-113
18987134-8	2009	At the center of this mechanism is an Ad knob arginine that needs to switch its orientation in order to engage CD46 with high affinity.	Arginine	46-54	CD46 molecule	Homo sapiens	111-115
19347309-6	2009	NO synthase 2 (NOS2) is induced by IFN-alpha or LPS and degrades arginine into OH-arginine and then into NO.	Arginine	65-73	nitric oxide synthase 2	Homo sapiens	0-13
19347309-6	2009	NO synthase 2 (NOS2) is induced by IFN-alpha or LPS and degrades arginine into OH-arginine and then into NO.	Arginine	65-73	nitric oxide synthase 2	Homo sapiens	15-19
19347309-6	2009	NO synthase 2 (NOS2) is induced by IFN-alpha or LPS and degrades arginine into OH-arginine and then into NO.	Arginine	65-73	interferon alpha 1	Homo sapiens	35-44
18957498-12	2009	The proinsulin secretory ratio (PISR) during glucose-potentiated arginine was significantly greater with GLP-1 vs. placebo infusion in both groups (P &lt; 0.05).	Arginine	65-73	insulin	Homo sapiens	4-14
18957505-9	2009	Major Outcome Measure: We measured insulin secretion in response to iv glucose and arginine before and after treatment and after drug washout.	Arginine	83-91	insulin	Homo sapiens	35-42
19390652-13	2009	Both tyrosine in amino acid 56 in CRYGD and arginine in amino acid 12 in CRYAA have been highly conserved throughout evolution in different species.	Arginine	44-52	crystallin alpha A	Homo sapiens	73-78
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Arginine	74-77	prepronociceptin	Homo sapiens	90-95
18418358-4	2009	These effects were counteracted by the N/OFQ receptor antagonist [Nphe(1) Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) confirming the specificity of N/OFQ action.	Arginine	74-77	prepronociceptin	Homo sapiens	90-95
20072949-3	2009	In the present work the distribution of genotypes and frequency of alleles of the T/C polymorphism in promoter region of CYP17 and Trp/Arg polymorphism in codon 39 of CYP19 gene in breast cancer women were investigated.	Arginine	135-138	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	167-172
19940524-1	2009	OBJECTIVES: Several studies have examined the association of codon 72 polymorphism of the TP53 gene, encoding either arginine or proline, in several tumor types but none have investigated its role in Kaposi"s sarcoma (KS) development.	Arginine	117-125	tumor protein p53	Homo sapiens	90-94
20072949-7	2009	However, the distribution of the genotypes of the Trp/Arg polymorphism of CYP19 in both control and patients did not differ significantly (p &gt; 0.05) from those predicted by the Hardy-Weinberg distribution.	Arginine	54-57	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	74-79
19053766-4	2008	Ac-Trp-[Arg(24),Lys(25),Asp(31),Pro(34),Phe(35)]CGRP(8-37)-NH(2), 5 (K(i) = 0.06 nM) had the highest CGRP(1) receptor affinity.	Arginine	8-11	calcitonin related polypeptide alpha	Homo sapiens	48-52
18939950-4	2009	Using site-directed mutagenesis, we determined that single arginine/lysine residues within the cytoplasmic tail are sufficient to promote rapid Golgi targeting of Golgi-resident N-acetylglucosaminyltransferase I (GnTI) and alpha-mannosidase II (GMII).	Arginine	59-67	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	163-211
18939950-4	2009	Using site-directed mutagenesis, we determined that single arginine/lysine residues within the cytoplasmic tail are sufficient to promote rapid Golgi targeting of Golgi-resident N-acetylglucosaminyltransferase I (GnTI) and alpha-mannosidase II (GMII).	Arginine	59-67	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	213-217
19877424-5	2009	However in the rat heart L-arginine administration prevents from TBA-reactive products and protein carbonyl derivates accumulation and the breaches of superoxide dismutase and catalase activities.	Arginine	25-35	catalase	Rattus norvegicus	176-184
18819916-1	2008	Prediction of export pathway specificity in prokaryotes is a challenging endeavor due to the similar overall architecture of N-terminal signal peptides for the Sec-, SRP- (signal recognition particle), and Tat (twin arginine translocation)-dependent pathways.	Arginine	216-224	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	206-209
19013076-1	2008	Recent studies demonstrated that inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity could be a new strategy to indirectly affect nitric oxide (NO) formation by elevating N(omega)-methylated L-arginine (NMMA, ADMA) levels.	Arginine	209-219	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	88-92
18829462-7	2008	One of the activating mutations, R68S, occurred in a residue conserved in the mammalian Erk1 (Arg-84) and Erk2 (Arg-65) and in the Drosophila ERK Rolled (Arg-80).	Arginine	94-97	mitogen-activated protein kinase 3	Homo sapiens	88-92
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Arginine	133-136	immunglobulin heavy chain variable region	Homo sapiens	71-75
18829462-7	2008	One of the activating mutations, R68S, occurred in a residue conserved in the mammalian Erk1 (Arg-84) and Erk2 (Arg-65) and in the Drosophila ERK Rolled (Arg-80).	Arginine	112-115	mitogen-activated protein kinase 1	Homo sapiens	106-110
18829462-7	2008	One of the activating mutations, R68S, occurred in a residue conserved in the mammalian Erk1 (Arg-84) and Erk2 (Arg-65) and in the Drosophila ERK Rolled (Arg-80).	Arginine	112-115	mitogen-activated protein kinase 1	Homo sapiens	106-110
18829462-9	2008	Combination of the Arg to Ser mutation with the sevenmaker mutation (producing Erk2(R65S+D319N) and Rolled(R80S+D334N)) resulted in even higher activity (45 and 70%, respectively, in reference to fully active dually phosphorylated Erk2 or Rolled).	Arginine	19-22	mitogen-activated protein kinase 1	Homo sapiens	79-83
18829462-9	2008	Combination of the Arg to Ser mutation with the sevenmaker mutation (producing Erk2(R65S+D319N) and Rolled(R80S+D334N)) resulted in even higher activity (45 and 70%, respectively, in reference to fully active dually phosphorylated Erk2 or Rolled).	Arginine	19-22	mitogen-activated protein kinase 1	Homo sapiens	231-235
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Arginine	147-150	immunglobulin heavy chain variable region	Homo sapiens	71-75
19120306-7	2008	We conclude that the C-terminal domain of human ZnT8 contains at least two discrete epitopes, one of which is critically dependent upon the arginine residue at position 325.	Arginine	140-148	solute carrier family 30 member 8	Homo sapiens	48-52
19008859-6	2008	These RPEL(MAL):G-actin structures explain the sequence conservation defining the RPEL motif, including the invariant arginine.	Arginine	118-126	mal, T cell differentiation protein	Homo sapiens	11-14
18818200-7	2008	An enhanced response to the knob "B" mimetic peptides Gly-His-Arg-Pro(am) and Ala-His-Arg-Pro(am) suggests that incorporation of nitrated fibrinogen molecules accelerates fibrin lateral aggregation.	Arginine	62-65	fibrinogen beta chain	Homo sapiens	138-148
19003935-5	2008	Previously it was shown that there are two polymorphic areas on the PON1 gene: one causing a Leu --&gt; Met substitution at 55th position, the other causing Gln --&gt; Arg at the 192nd position.	Arginine	168-171	paraoxonase 1	Homo sapiens	68-72
18932250-4	2008	Growth hormone (GH)-releasing hormone-arginine stimulation testing was conducted to evaluate peak GH level, and insulin-like growth factor I (IGF-I) and other markers of endocrine functioning were also evaluated in relation to BMD.	Arginine	38-46	growth hormone 1	Homo sapiens	0-14
18932250-4	2008	Growth hormone (GH)-releasing hormone-arginine stimulation testing was conducted to evaluate peak GH level, and insulin-like growth factor I (IGF-I) and other markers of endocrine functioning were also evaluated in relation to BMD.	Arginine	38-46	growth hormone 1	Homo sapiens	16-18
18981330-0	2008	Exogenous L-arginine ameliorates angiotensin II-induced hypertension and renal damage in rats.	Arginine	10-20	angiotensinogen	Rattus norvegicus	33-47
19075752-3	2008	NO is an ubiquitous molecule synthesised from L-arginine under the catalytic action of different nitric oxide synthase (NOS) isoforms and its altered production has been reported to be involved in several diseases.	Arginine	46-56	nitric oxide synthase 2	Homo sapiens	97-118
18981330-1	2008	Experiments were performed to determine whether exogenous L-arginine could ameliorate angiotensin II-induced hypertension and renal damage.	Arginine	58-68	angiotensinogen	Rattus norvegicus	86-100
18981330-4	2008	In contrast, the increase in arterial pressure after 9 days of angiotensin II infusion was significantly blunted by 45% (P=0.0003) in rats coadministered L-arginine (300 microg/kg per minute; IV; n=7 to 9).	Arginine	154-164	angiotensinogen	Rattus norvegicus	63-77
18981330-6	2008	Coinfusion of L-arginine significantly increased plasma nitrate/nitrite concentrations (P&lt;0.001) and completely prevented angiotensin II-induced glomerular damage (P&lt;0.001).	Arginine	14-24	angiotensinogen	Rattus norvegicus	125-139
18981330-9	2008	Our experiments demonstrate that L-arginine can blunt angiotensin II-induced hypertension and associated renal damage.	Arginine	33-43	angiotensinogen	Rattus norvegicus	54-68
23675098-3	2008	The TP53 codon 72 polymorphism is a single-nucleotide polymorphism (SNP) in exon 4, resulting in the expression of either arginine (CGC) or proline (CCC) residues.	Arginine	122-130	tumor protein p53	Homo sapiens	4-8
19127115-7	2008	Direct sequencing of TP53 gene exons 5, 6, 8, 9, and 11 revealed a ermline missense mutation, resulting in an amino acid change from an arginine to a histidine (g.13203G&gt;A, p.R175H).	Arginine	136-144	tumor protein p53	Homo sapiens	21-25
19022976-0	2008	Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn"s patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways.	Arginine	23-31	mitogen-activated protein kinase 14	Homo sapiens	168-171
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	tumor necrosis factor	Homo sapiens	48-56
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	interleukin 1 beta	Homo sapiens	58-66
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
19022976-7	2008	Arg(high)/Gln(high) decreased the production of TNFalpha, IL-1beta, IL-8, and IL-6 (each P &lt; 0.01).	Arginine	0-3	interleukin 6	Homo sapiens	78-82
19022976-8	2008	Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P &lt; 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production.	Arginine	0-3	interleukin 6	Homo sapiens	29-33
19022976-8	2008	Arg(low)/Gln(high) decreased IL-6 and IL-8 production (both P &lt; 0.01), whereas Arg(high)/Gln(low) did not affect cytokine and NO production.	Arginine	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19022976-10	2008	Combined pharmacological doses of Arg and Gln decreased TNFalpha and the main proinflammatory cytokines release in active colonic CD biopsies via NF-kappaB and p38 MAPK pathways.	Arginine	34-37	tumor necrosis factor	Homo sapiens	56-64
19022976-10	2008	Combined pharmacological doses of Arg and Gln decreased TNFalpha and the main proinflammatory cytokines release in active colonic CD biopsies via NF-kappaB and p38 MAPK pathways.	Arginine	34-37	mitogen-activated protein kinase 14	Homo sapiens	160-163
19013291-0	2008	Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency.	Arginine	39-47	growth hormone 1	Homo sapiens	11-25
19013291-9	2008	There was a positive correlation between IGF-1 and cyclic guanosine monophosphate (r = 0.73, P &lt; .0001), IGF-1 and reactive hyperemia (r = 0.63, P &lt; .0001), and IGF-1 and Arg/ADMA ratio (r = 0.44, P &lt; .01).	Arginine	177-180	insulin like growth factor 1	Homo sapiens	41-46
18726898-11	2008	Arginine and tyrosine are significantly (P = 4.07E-08 and P = 3.27E-04, respectively) the AVPR2 most commonly mutated amino acids.	Arginine	0-8	arginine vasopressin receptor 2	Homo sapiens	90-95
19396385-3	2008	FMRP has been shown to use its arginine-glycine-glycine rich region (RGG box) to bind to messenger RNAs that form G quadruplex structures.	Arginine	31-39	fragile X messenger ribonucleoprotein 1	Homo sapiens	0-4
19043433-2	2008	Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53.	Arginine	5-13	tumor protein p53	Homo sapiens	98-101
18805448-7	2008	Two families of variants of GLT-1 were prepared with various lysine residues mutated to arginine.	Arginine	88-96	solute carrier family 1 member 2	Homo sapiens	28-33
19011621-0	2008	Arginine methylation regulates the p53 response.	Arginine	0-8	tumor protein p53	Homo sapiens	35-38
19011621-5	2008	Arginine methylation is regulated during the p53 response and affects the target gene specificity of p53.	Arginine	0-8	tumor protein p53	Homo sapiens	45-48
18991340-2	2008	NO is synthesized from arginine by the action of NO-synthase (NOS).	Arginine	23-31	nitric oxide synthase 2	Homo sapiens	49-60
19011621-5	2008	Arginine methylation is regulated during the p53 response and affects the target gene specificity of p53.	Arginine	0-8	tumor protein p53	Homo sapiens	101-104
19011621-7	2008	Thus, methylation on arginine residues is an underlying mechanism of control during the p53 response.	Arginine	21-29	tumor protein p53	Homo sapiens	88-91
18807245-3	2008	In this paper, we describe a new [(3)H]labeled NOP antagonist, [Nphe(1),4"-(3)H-Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) ([(3)H]UFP-101).	Arginine	87-90	prepronociceptin	Homo sapiens	47-50
18807245-3	2008	In this paper, we describe a new [(3)H]labeled NOP antagonist, [Nphe(1),4"-(3)H-Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) ([(3)H]UFP-101).	Arginine	87-90	prepronociceptin	Homo sapiens	103-108
19280995-3	2008	Two common polymorphisms in the coding region of the PON1 gene, which lead to a glutamine (Q)/arginine (R) substitution at position 192 and a leucine (L)/methionine (M) substitution at position 55, influence PON1 activity.	Arginine	94-102	paraoxonase 1	Homo sapiens	53-57
25941893-2	2008	Therapeutic use of supplemental arginine has been proposed as an efficacious method to produce nitric oxide (NO) from nitric oxide synthase (NOS) and proline and polyamines from arginase to improve wound healing.	Arginine	32-40	nitric oxide synthase 2	Sus scrofa	118-139
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Arginine	71-74	tumor protein p53	Homo sapiens	33-36
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Arginine	75-78	tumor protein p53	Homo sapiens	33-36
19137883-9	2008	RESULTS: The genetic genotype of p53 gene codon 72 in keloids included Arg/Arg in 7 cases, Pro/Arg in 21 cases, Pro/ Pro in 7 cases.	Arginine	75-78	tumor protein p53	Homo sapiens	33-36
19134269-4	2008	RESULTS: In ZZJ family, mutation G12101A was identified in exon 21 of MYBPC3 gene in 4 family members [the arginine (R) converted to histidine (H)].	Arginine	107-115	myosin binding protein C3	Homo sapiens	70-76
18981409-3	2008	To determine whether Bax regulation requires its binding by prosurvival relatives, we replaced a conserved aspartate in its BH3 interaction domain with arginine.	Arginine	152-160	BCL2 associated X, apoptosis regulator	Homo sapiens	21-24
18773938-6	2008	Furthermore, we demonstrated that Btg2, one of the PRMT1 binding partner, depletion down-regulated arginine methylation in the nucleus and inhibited neurite outgrowth.	Arginine	99-107	BTG anti-proliferation factor 2	Mus musculus	34-38
18829457-6	2008	Our studies reveal that WDR5 preferentially recognizes a previously unidentified and conserved arginine-containing motif, called the "Win" or WDR5 interaction motif, which is located in the N-SET region of MLL1 and other SET1 family members.	Arginine	95-103	WD repeat domain 5	Homo sapiens	24-28
18829457-6	2008	Our studies reveal that WDR5 preferentially recognizes a previously unidentified and conserved arginine-containing motif, called the "Win" or WDR5 interaction motif, which is located in the N-SET region of MLL1 and other SET1 family members.	Arginine	95-103	WD repeat domain 5	Homo sapiens	142-146
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	78-86	WD repeat domain 5	Homo sapiens	62-66
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	78-86	WD repeat domain 5	Homo sapiens	156-160
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	129-137	WD repeat domain 5	Homo sapiens	62-66
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	129-137	WD repeat domain 5	Homo sapiens	156-160
18829457-8	2008	We demonstrate that WDR5"s recognition of arginine 3765 of MLL1 is essential for the assembly and enzymatic activity of the MLL1 core complex in vitro.	Arginine	42-50	WD repeat domain 5	Homo sapiens	20-24
18829459-2	2008	In the accompanying investigation, we describe the identification of a conserved arginine containing motif, called the "Win" or WDR5 interaction motif, that is essential for the assembly and H3K4 dimethylation activity of the MLL1 core complex.	Arginine	81-89	WD repeat domain 5	Homo sapiens	128-132
18829459-4	2008	Our results show that Arg-3765 of MLL1 is bound in the same arginine binding pocket on WDR5 that was previously suggested to bind histone H3.	Arginine	22-25	WD repeat domain 5	Homo sapiens	87-91
18829459-4	2008	Our results show that Arg-3765 of MLL1 is bound in the same arginine binding pocket on WDR5 that was previously suggested to bind histone H3.	Arginine	60-68	WD repeat domain 5	Homo sapiens	87-91
18829459-6	2008	These results are consistent with a model in which WDR5 recognizes Arg-3765 of MLL1, which is essential for the assembly and enzymatic activity of the MLL1 core complex.	Arginine	67-70	WD repeat domain 5	Homo sapiens	51-55
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	57-60	tumor protein p53	Homo sapiens	52-55
19014451-10	2008	Direct sequencing of HSF4 revealed the nucleotide exchange c.1213C&gt;T in this family predicting an arginine to stop codon exchange (p.R405X).	Arginine	101-109	heat shock transcription factor 4	Homo sapiens	21-25
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	61-64	tumor protein p53	Homo sapiens	52-55
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	61-64	tumor protein p53	Homo sapiens	52-55
18660502-5	2008	A novel upstream RhoA mediator was shown to be ABL2, also known as ARG, a membrane-anchored nonreceptor tyrosine kinase.	Arginine	67-70	ras homolog family member A	Homo sapiens	17-21
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	13-16	pro-melanin concentrating hormone	Homo sapiens	259-262
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	26-29	pro-melanin concentrating hormone	Homo sapiens	259-262
18765508-0	2008	The effects of central adiposity on growth hormone (GH) response to GH-releasing hormone-arginine stimulation testing in men.	Arginine	89-97	growth hormone 1	Homo sapiens	68-70
18765508-12	2008	CONCLUSIONS: GH response to GHRH-arginine testing is reduced in both overweight and obese subjects and negatively associated with indices of central abdominal obesity including WC, trunk fat, and visceral adipose tissue.	Arginine	33-41	growth hormone 1	Homo sapiens	13-15
18765508-12	2008	CONCLUSIONS: GH response to GHRH-arginine testing is reduced in both overweight and obese subjects and negatively associated with indices of central abdominal obesity including WC, trunk fat, and visceral adipose tissue.	Arginine	33-41	growth hormone releasing hormone	Homo sapiens	28-32
18953334-4	2008	Reconstitution experiments reveal that Ca2+-synaptotagmin-1 can dramatically stimulate the rate of SNARE-dependent lipid mixing, and that the two-arginine mutation strongly impairs this activity.	Arginine	146-154	small NF90 (ILF3) associated RNA E	Homo sapiens	99-104
18449561-2	2008	Mutation of two positively charged arginine residues in the first extracellular loop (ECL) of CFTR, R104, and R117, as well as lysine residue K335 in the sixth transmembrane region, leads to inward rectification of the current-voltage relationship and decreased single channel conductance.	Arginine	35-43	CF transmembrane conductance regulator	Homo sapiens	94-98
18564064-7	2008	Exposure of MCs to RGD (Arg-Gly-Asp) peptide led to abrogation of the anti-apoptotic effect of uPA, which implies involvement of integrins in this process.	Arginine	24-27	plasminogen activator, urokinase	Homo sapiens	95-98
18854029-1	2008	BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins.	Arginine	284-292	ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)	Homo sapiens	18-22
18854029-8	2008	Upon ectopic expression in C-33A cells, recombinant chicken ART4 localized at the cell surface as a GPI-anchored, highly glycosylated protein, which displayed arginine-specific ART activity (apparent Km of the recombinant protein for etheno-NAD+ 1.0 +/- 0.18 microM).	Arginine	159-167	ADP-ribosyltransferase 1 like 2	Gallus gallus	60-63
18669635-4	2008	Rodent embryonic fibroblasts adhered to PF1 and deletion fragments, and, when cells were plated on fibrillin-1 or fibronectin Arg-Gly-Asp cell-binding fragments, cells showed heparin-dependent spreading and focal contact formation in response to soluble PF1.	Arginine	126-129	fibronectin 1	Homo sapiens	114-125
18692035-4	2008	RESULTS: The -765GC+CC genotypes of COX2 and Pro/Pro+Pro/Arg genotypes of p53 were prevalent in patients with significant odds ratio, 2.05 and 2.30, respectively (p=0.001; p=0.009, respectively), as a consequence, the -765C and 72Pro alleles were prevalent (p&lt;or=0.001).	Arginine	57-60	tumor protein p53	Homo sapiens	74-77
19093029-3	2008	Deimination, the conversion of protein-bound arginine to citrulline, is mediated by the peptidylarginine deiminase (PAD) family of enzymes, of which the PAD2 and PAD4 isoforms are present in myelin.	Arginine	45-53	paddle	Mus musculus	88-114
19093029-3	2008	Deimination, the conversion of protein-bound arginine to citrulline, is mediated by the peptidylarginine deiminase (PAD) family of enzymes, of which the PAD2 and PAD4 isoforms are present in myelin.	Arginine	45-53	paddle	Mus musculus	116-119
18719233-3	2008	The activation/upregulation of arginase appears to be an important contributor to age-related endothelial dysfunction by a mechanism that involves substrate (L-arginine) limitation for NO synthase (NOS) 3 and therefore NO synthesis.	Arginine	158-168	nitric oxide synthase 3	Homo sapiens	185-204
19140314-5	2008	According to data received, certain genetic markers associated with impaired glucose tolerance and/or insulin resistance (namely, leptin receptor genotypes 223 Gln/Arg and Gln/Gln) are revealed in oncological patients more often than in females without cancer.	Arginine	164-167	insulin	Homo sapiens	102-109
18765660-4	2008	The second, at Arg(271), yields thrombin and severs covalent linkage with the N-terminal fragment 1.2 (F12) region.	Arginine	15-18	coagulation factor II, thrombin	Homo sapiens	32-40
18951090-0	2008	Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.	Arginine	0-8	AKT serine/threonine kinase 1	Homo sapiens	85-88
18951090-8	2008	Our findings predict a role for arginine methylation as an inhibitory modification against Akt-mediated phosphorylation.	Arginine	32-40	AKT serine/threonine kinase 1	Homo sapiens	91-94
18818087-1	2008	Nociceptin is an endogenous ligand that activates a G protein-coupled receptor ORL1 and contains two indispensable Arg-Lys (RK) dipeptide units at positions 8-9 and 12-13.	Arginine	115-118	prepronociceptin	Homo sapiens	0-10
18660502-10	2008	Together, these results suggested that ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity.	Arginine	44-47	ras homolog family member A	Homo sapiens	86-90
18800818-3	2008	However, when the peptide Arg-Gly-Asp (RGD) was introduced into ES-2, the modified ES-2 showed significant antitumor results in animal models.	Arginine	26-29	ess-2 splicing factor homolog	Homo sapiens	64-68
18491415-0	2008	NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution.	Arginine	76-79	insulin	Homo sapiens	47-54
18805011-4	2008	It is synthesised by nitric oxide synthase (NOS) from L-arginine and its overproduction could lead to a number of neurological disorders.	Arginine	54-64	nitric oxide synthase 2	Homo sapiens	21-42
18800818-3	2008	However, when the peptide Arg-Gly-Asp (RGD) was introduced into ES-2, the modified ES-2 showed significant antitumor results in animal models.	Arginine	26-29	ess-2 splicing factor homolog	Homo sapiens	83-87
18829591-9	2008	Furthermore, we detected a decrease in arginine levels over the study period, suggesting that the iNOS/citrulline pathway predominated during the first 72 hr of treatment, and the arginase/ ornithine pathway dominated thereafter.	Arginine	39-47	nitric oxide synthase 2	Homo sapiens	98-102
18645041-3	2008	In this report, we identified a novel naturally occurring posttranslational modification of chemokines, that is, the deimination of arginine at position 5 into citrulline of CXC chemokine ligand 10 (CXCL10) by rabbit PAD and human PAD2.	Arginine	132-140	C-X-C motif chemokine 10	Oryctolagus cuniculus	174-197
18645041-3	2008	In this report, we identified a novel naturally occurring posttranslational modification of chemokines, that is, the deimination of arginine at position 5 into citrulline of CXC chemokine ligand 10 (CXCL10) by rabbit PAD and human PAD2.	Arginine	132-140	C-X-C motif chemokine 10	Oryctolagus cuniculus	199-205
18632687-1	2008	Our previous work has demonstrated that the Tudor domain of the "survival of motor neuron" protein and the Tudor domain-containing protein 3 (TDRD3) are highly similar and that they both have the ability to interact with arginine-methylated polypeptides.	Arginine	221-229	tudor domain containing 3	Homo sapiens	107-140
18759245-9	2008	Arginase competes with iNOS for arginine, catalyzing its hydrolysis to ornithine and urea.	Arginine	32-40	nitric oxide synthase 2	Homo sapiens	23-27
18505438-6	2008	Elevated rates of L-arginine transport in Dengue fever patients were associated with enhanced NO synthase activity and elevated plasma fibrinogen levels.	Arginine	18-28	fibrinogen beta chain	Homo sapiens	135-145
18518882-7	2008	L-arginine supplementation increased mRNA expression of all NOS isoforms, but only increased protein expression of iNOS.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	115-119
18535109-15	2008	In summary, PRL/E2-induced cell-surface CPD released Arg from extracellular substrates, increased intracellular NO, promoted survival and inhibited apoptosis of MCF-7 cells.	Arginine	53-56	prolactin	Homo sapiens	12-15
18718857-2	2008	It is produced in vivo from the aminoacid l-arginine by a family of nitric oxide synthases (NOS).	Arginine	42-52	nitric oxide synthase 2	Homo sapiens	68-90
18632687-1	2008	Our previous work has demonstrated that the Tudor domain of the "survival of motor neuron" protein and the Tudor domain-containing protein 3 (TDRD3) are highly similar and that they both have the ability to interact with arginine-methylated polypeptides.	Arginine	221-229	tudor domain containing 3	Homo sapiens	142-147
18632687-9	2008	Taken together, we report the first characterization of TDRD3 and its functional interaction with at least two proteins implicated in human genetic diseases and present evidence supporting a role for arginine methylation in the regulation of SG dynamics.	Arginine	200-208	tudor domain containing 3	Homo sapiens	56-61
18774806-1	2008	We present here results of a series of density functional theory (DFT) studies on enzyme active site models of nitric oxide synthase (NOS) and address the key steps in the catalytic cycle whereby the substrate (L-arginine) is hydroxylated to N(omega)-hydroxo-arginine.	Arginine	211-221	nitric oxide synthase 2	Homo sapiens	111-132
18627024-8	2008	These results highlight the important role of L-arg in the neuron-microglia coculture in excessive induction of iNOS.	Arginine	46-51	nitric oxide synthase 2	Homo sapiens	112-116
19145674-17	2008	CONCLUSION: Our results showed low incidence of p53 mutations and prevalence of Arg/Arg genotype polymorphic variant of codon 72 of p53 gene in early stages of cervical carcinoma.	Arginine	80-83	tumor protein p53	Homo sapiens	132-135
19145674-17	2008	CONCLUSION: Our results showed low incidence of p53 mutations and prevalence of Arg/Arg genotype polymorphic variant of codon 72 of p53 gene in early stages of cervical carcinoma.	Arginine	84-87	tumor protein p53	Homo sapiens	132-135
18797415-3	2008	This finding suggests that the effect of arginine analog NOS inhibitors is through a non-iNOS-mediated mechanism.	Arginine	41-49	nitric oxide synthase 2, inducible	Mus musculus	89-93
18662997-3	2008	Precedence to other AAA(+) proteins suggests that Mcm ATPase active sites are formed combinatorially, with Walker A and B motifs contributed by one subunit and a catalytically essential arginine (arginine finger) contributed by the adjacent subunit.	Arginine	186-194	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	50-53
18710948-10	2008	A ubiquitination-deficient mutant of IRF7 with these sites mutated to arginines completely loses transactivational ability in response not only to LMP1 but also to the IRF7 kinase IkappaB kinase epsilon.	Arginine	70-79	interferon regulatory factor 7	Homo sapiens	37-41
18710948-10	2008	A ubiquitination-deficient mutant of IRF7 with these sites mutated to arginines completely loses transactivational ability in response not only to LMP1 but also to the IRF7 kinase IkappaB kinase epsilon.	Arginine	70-79	interferon regulatory factor 7	Homo sapiens	168-172
18384083-12	2008	We discuss structural features that produce this novel binding motif, including the role of the CaMBD peptide residues Arg-408, Val-409, and Phe-410, which work to provide rigidity to the otherwise flexible central CaM helix joining the N- and C-lobes, ultimately keeping these lobes apart and forcing "head-to-tail" dimerization to attain the requisite N- and C-lobe pairing for CaMBD binding.	Arginine	119-122	calmodulin 1	Homo sapiens	96-99
18676353-4	2008	Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated.	Arginine	42-50	protein arginine methyltransferase 6	Homo sapiens	169-174
18676353-5	2008	In contrast, both up- and down-regulations of symmetrically arginine-methylated proteins (the product of type II PRMTs including PRMT5) during replicative senescence were found.	Arginine	60-68	protein arginine methyltransferase 5	Homo sapiens	129-134
18796734-4	2008	Sequence analysis showed that the mutated Rep gene had three nucleotide changes (A6--&gt;T, T375--&gt;G and G852--&gt;A); only the A6--&gt;T transversion resulted in an amino acid substitution (Arg to Ser), which is at the second residue in the 358 amino acid ACMV Rep protein.	Arginine	194-197	Rep	African cassava mosaic virus	42-45
18581203-3	2008	AVP significantly increased DNA synthesis in adult rat CFs by 73.5 +/- 5.1% (P &lt; or = 0.05), an effect inhibited by V1 receptor antagonist, d(CH(2))(5)[Tyr(2)(Me), Arg(8)]-vasopressin.	Arginine	167-170	arginine vasopressin	Rattus norvegicus	0-3
18706698-7	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	hemolytic complement	Mus musculus	66-69
18706698-7	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	coagulation factor II	Mus musculus	86-94
18627024-9	2008	Regulation of L-arg by ADI demonstrated that rADI has a potentially therapeutic role in iNOS-related neuronal diseases.	Arginine	14-19	nitric oxide synthase 2	Homo sapiens	88-92
18644376-5	2008	A positively charged arginine at position 512 in the n-Src loop of Eps8L1 SH3 plays a key role in PxxDY motif recognition by forming a salt bridge to D7 of the CD3epsilon peptide.	Arginine	21-29	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	55-58
18596043-2	2008	P-glycoprotein (ABCB1) is a useful model system because introduction of an arginine at position 65 of the first transmembrane (TM) segment could repair folding defects.	Arginine	75-83	ATP binding cassette subfamily B member 1	Homo sapiens	16-21
18635542-5	2008	Mutation of the central arginine (Arg-90) in a surface-exposed basic RRK motif unique to NDPK-D strongly reduced interaction with anionic phospholipids.	Arginine	24-32	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	89-95
18635542-5	2008	Mutation of the central arginine (Arg-90) in a surface-exposed basic RRK motif unique to NDPK-D strongly reduced interaction with anionic phospholipids.	Arginine	34-37	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	89-95
18773997-6	2008	The beta1-389Gly homozygotes had significantly less nonsustained ventricular tachycardia on Holter monitoring (17% vs 48% for Arg/Arg patients; p = 0.015) and improved HF-related survival, with no events after a median follow-up of 40 months (log-rank statistics = 0.025).	Arginine	126-129	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-9
18773997-6	2008	The beta1-389Gly homozygotes had significantly less nonsustained ventricular tachycardia on Holter monitoring (17% vs 48% for Arg/Arg patients; p = 0.015) and improved HF-related survival, with no events after a median follow-up of 40 months (log-rank statistics = 0.025).	Arginine	130-133	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-9
18817562-13	2008	nor-NOHA significantly (P = 0.01) reduced arginase II activity and suppressed cell growth in cells exhibiting high arginase activity.The depletion of L-arginine by mRCC induced the decrease expression of CD3zeta a key element for T-cell function.	Arginine	150-160	CD247 antigen	Mus musculus	204-211
18757760-7	2008	The impairment in Pro and Arg synthesis results in 14-fold overexpression of E383A ProA, providing sufficient N-acetylglutamylphosphate reductase activity to allow a strain lacking ArgC to grow on glucose.	Arginine	26-29	PROA	Homo sapiens	83-87
18200441-4	2008	In our case-control study, we assess whether Msp1 polymorphism of CYP1A1 (CYP1A1*2A), and His(113) in exon 3 and Arg(139) in exon 4 of the mEH susceptibility genotypes, tobacco-use and age factors contribute to bladder cancer risk among Indians.	Arginine	113-116	epoxide hydrolase 1, microsomal	Mus musculus	139-142
18688868-6	2008	Based on the low frequency audioprofile, mutation screening of WFS1 was completed and a novel missense mutation (c.2576G --> A) that results in an arginine-to-glutamine substitution (p.R859Q) was identified in the C-terminal domain of the wolframin protein where most LFSNHL-causing mutations cluster.	Arginine	147-155	wolframin ER transmembrane glycoprotein	Homo sapiens	63-67
18688868-6	2008	Based on the low frequency audioprofile, mutation screening of WFS1 was completed and a novel missense mutation (c.2576G --> A) that results in an arginine-to-glutamine substitution (p.R859Q) was identified in the C-terminal domain of the wolframin protein where most LFSNHL-causing mutations cluster.	Arginine	147-155	wolframin ER transmembrane glycoprotein	Homo sapiens	239-248
18492952-3	2008	By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668), and together these exosite interactions increase the rate of substrate cleavage by at least approximately 300-fold.	Arginine	200-203	thrombospondin 1	Homo sapiens	79-95
18573314-1	2008	Protein arginine methyltransferase 3 (PRMT3) comprises a region not required for catalytic activity in its amino-terminus and the core domain catalyzing protein arginine methylation.	Arginine	8-16	protein arginine methyltransferase 3	Homo sapiens	38-43
18573314-2	2008	PRMT3 has been shown to interact with the 40S ribosomal protein S2 (rpS2) and methylate arginine residues in the arginine-glycine (RG) repeat region in the amino-terminus of rpS2.	Arginine	88-96	protein arginine methyltransferase 3	Homo sapiens	0-5
18573314-2	2008	PRMT3 has been shown to interact with the 40S ribosomal protein S2 (rpS2) and methylate arginine residues in the arginine-glycine (RG) repeat region in the amino-terminus of rpS2.	Arginine	88-96	ribosomal protein S2	Homo sapiens	174-178
18492952-3	2008	By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668), and together these exosite interactions increase the rate of substrate cleavage by at least approximately 300-fold.	Arginine	200-203	von Willebrand factor	Homo sapiens	164-167
18502798-2	2008	Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS]-VWF73) was investigated by a fluorescence quenching method (FRETS method) from 15 degrees C to 45 degrees C and pH values from 4.5 to 10.5.	Arginine	50-53	von Willebrand factor	Homo sapiens	28-31
18502798-8	2008	The interaction of the Met(1606)-Arg(1668) region of VWF with ADAMTS13 involves basic residues of the protease and is thus progressively inhibited at pH values &gt;8.50.	Arginine	33-36	von Willebrand factor	Homo sapiens	53-56
18776696-0	2008	Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.	Arginine	58-61	cystathionine beta-synthase	Homo sapiens	14-41
18776696-0	2008	Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.	Arginine	69-72	cystathionine beta-synthase	Homo sapiens	14-41
18710930-4	2008	Citrullination of arginine in position 5 was discovered on 14% of natural leukocyte-derived CXCL8(1-77), generating CXCL8(1-77)Cit(5).	Arginine	18-26	interleukin-8	Oryctolagus cuniculus	92-97
18524873-7	2008	An induced fit docking of the ligands with an X-ray crystal structure of substrate-free CYP2D6 (Protein Data Bank code 2F9Q) indicated the involvement of an electrostatic interaction between the carboxyl group and Arg(221) and hydrophobic interaction between the aromatic moiety and Phe(483).	Arginine	214-217	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	88-94
18524873-11	2008	Further investigation, such as a site-directed mutation, will be necessary to directly demonstrate the involvement of Arg(221) in CYP2D6 binding.	Arginine	118-121	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	130-136
18710930-4	2008	Citrullination of arginine in position 5 was discovered on 14% of natural leukocyte-derived CXCL8(1-77), generating CXCL8(1-77)Cit(5).	Arginine	18-26	interleukin-8	Oryctolagus cuniculus	116-121
18716165-0	2008	Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase.	Arginine	0-8	caudal type homeo box 2	Rattus norvegicus	20-24
18390929-2	2008	Concern has been raised, however, that under conditions of hyperinflammation, these diets may be injurious through the induction of inducible NO synthase by enteral arginine.	Arginine	165-173	nitric oxide synthase 2	Homo sapiens	132-153
18716165-3	2008	When treated with Arg, cdx2-IEC increased in phosphorylation on Thr-389 of p70(s6k) (pp70(s6k)) compared with control (P &lt; 0.01).	Arginine	18-21	caudal type homeo box 2	Rattus norvegicus	23-27
18710925-2	2008	alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit.	Arginine	40-44	fibrinogen beta chain	Homo sapiens	22-32
18758421-2	2008	A common polymorphism at codon 72 of exon 4 of the p53 gene encoding either an arginine or proline has been shown to confer susceptibility to the development of different human malignancies.	Arginine	79-87	tumor protein p53	Homo sapiens	51-54
19759857-1	2008	Nitric oxide synthase (NOS) catalyzes the production of nitric oxide from L-arginine and dioxygen at a thiolate-ligated heme active site.	Arginine	74-84	nitric oxide synthase 2	Homo sapiens	0-21
18579533-3	2008	Conversion of this lysine to an arginine (K51R) substantially reduced Nkx2.5 DNA binding and also its transcriptional activity.	Arginine	32-40	NK2 homeobox 5	Homo sapiens	70-76
18710925-2	2008	alpha(v)beta(3) binds fibrinogen via an Arg-Asp-Gly (RGD) motif in fibrinogen"s alpha subunit.	Arginine	40-44	fibrinogen beta chain	Homo sapiens	67-77
18725938-6	2008	One site, an arginine (RXR) motif in the N-terminal alpha helical domain of Nef, is necessary for maximal MHC-I degradation.	Arginine	13-21	S100 calcium binding protein B	Homo sapiens	76-79
18544645-3	2008	We hypothesized that low-peak GH on the GH-releasing hormone (GHRH)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids.	Arginine	68-76	growth hormone 1	Homo sapiens	30-32
18619441-1	2008	The H-bonded complex of ATP with Arg 34 of Zn2+ finger I of poly-ADP-ribose polymerase-1 (PARP-1) determines trans-oligo-ADP-ribosylation from NAD+ to proteins other than PARP-1.	Arginine	33-36	poly(ADP-ribose) polymerase 1	Homo sapiens	60-88
18619441-1	2008	The H-bonded complex of ATP with Arg 34 of Zn2+ finger I of poly-ADP-ribose polymerase-1 (PARP-1) determines trans-oligo-ADP-ribosylation from NAD+ to proteins other than PARP-1.	Arginine	33-36	poly(ADP-ribose) polymerase 1	Homo sapiens	90-96
18619441-1	2008	The H-bonded complex of ATP with Arg 34 of Zn2+ finger I of poly-ADP-ribose polymerase-1 (PARP-1) determines trans-oligo-ADP-ribosylation from NAD+ to proteins other than PARP-1.	Arginine	33-36	poly(ADP-ribose) polymerase 1	Homo sapiens	171-177
18656952-0	2008	Chemical and structural probing of the N-terminal residues encoded by FMR1 exon 15 and their effect on downstream arginine methylation.	Arginine	114-122	fragile X messenger ribonucleoprotein 1	Homo sapiens	70-74
18656952-12	2008	These data support a novel model for FMRP arginine methylation and a role for conformational switch residues in arginine modification.	Arginine	42-50	fragile X messenger ribonucleoprotein 1	Homo sapiens	37-41
18695041-0	2008	dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.	Arginine	44-52	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	0-4
18695041-0	2008	dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes.	Arginine	44-52	Lysine ketoglutarate reductase/saccharopine dehydrogenase	Drosophila melanogaster	5-8
18524858-3	2008	Since l-arginine transport by CAT-1 (the specific arginine transporter for eNOS) is inhibited in uremia, we aimed to explore the effect of rosiglitazone on arginine transport in CRF.	Arginine	6-16	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	30-35
18524858-3	2008	Since l-arginine transport by CAT-1 (the specific arginine transporter for eNOS) is inhibited in uremia, we aimed to explore the effect of rosiglitazone on arginine transport in CRF.	Arginine	8-16	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	30-35
18544645-3	2008	We hypothesized that low-peak GH on the GH-releasing hormone (GHRH)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids.	Arginine	68-76	growth hormone releasing hormone	Homo sapiens	40-60
18544645-3	2008	We hypothesized that low-peak GH on the GH-releasing hormone (GHRH)-arginine stimulation test and high cortisol in overweight adolescents would be associated with higher regional fat, insulin resistance, and lipids.	Arginine	68-76	growth hormone releasing hormone	Homo sapiens	62-66
18544645-6	2008	Log peak GH on the GHRH-arginine test was lower (P = 0.03) and log UFC was higher (P = 0.02) in overweight girls.	Arginine	24-32	growth hormone 1	Homo sapiens	9-11
18544645-6	2008	Log peak GH on the GHRH-arginine test was lower (P = 0.03) and log UFC was higher (P = 0.02) in overweight girls.	Arginine	24-32	growth hormone releasing hormone	Homo sapiens	19-23
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Arginine	49-57	RELB proto-oncogene, NF-kB subunit	Homo sapiens	18-22
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Arginine	49-57	RELB proto-oncogene, NF-kB subunit	Homo sapiens	103-107
18462924-6	2008	Here we show that RelB, instead, has a bipartite arginine/lysine-rich NLS that mediates the binding of RelB to importin alpha5 and alpha6 and subsequent nuclear translocation of the protein.	Arginine	49-57	karyopherin subunit alpha 1	Homo sapiens	111-126
18636161-6	2008	However, expression of the deamidated mutant of Bcl-xL, in which aspartic acid was substituted for both arginine 52 and 66 (N52,66D-Bcl-xL), exhibited high sensitivity for the induction of apoptosis.	Arginine	104-112	BCL2 like 1	Homo sapiens	48-54
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	79-82	tumor protein p53	Homo sapiens	23-26
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	83-86	tumor protein p53	Homo sapiens	23-26
17931634-10	2008	CONCLUSION(S): The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations.	Arginine	52-55	tumor protein p53	Homo sapiens	72-75
17931634-10	2008	CONCLUSION(S): The negative association between the Arg/Arg genotype of p53 codon 72 found in Chinese people has not been observed in Japanese and Italian populations.	Arginine	56-59	tumor protein p53	Homo sapiens	72-75
18429990-8	2008	Both SMT and L-arginine effectively reduced CCl(4) induced oxidative stress and collagen formation, but L-arginine showed a significantly greater suppression of collagen formation, iNOS expression and NF-kappaB activity.	Arginine	104-114	nitric oxide synthase 2, inducible	Mus musculus	181-185
18429990-8	2008	Both SMT and L-arginine effectively reduced CCl(4) induced oxidative stress and collagen formation, but L-arginine showed a significantly greater suppression of collagen formation, iNOS expression and NF-kappaB activity.	Arginine	104-114	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	201-210
18221393-6	2008	Serum IGF-1 levels and peak GH levels in the patients that passed the GHRH-arginine test were compared with 22 age- and BMI-matched healthy controls.	Arginine	75-83	growth hormone releasing hormone	Homo sapiens	70-74
18221393-8	2008	Peak GH levels in patients that passed the GHRH-arginine test were lower compared to healthy controls and 19 patients (50%) had at least one other pituitary hormone deficit.	Arginine	48-56	growth hormone releasing hormone	Homo sapiens	43-47
18221393-10	2008	CONCLUSIONS: Our data demonstrated that a substantial number of patients with nonsecreting pituitary microadenomas failed the GHRH-arginine test despite normal serum IGF-1 levels, and had at least one other pituitary hormone deficiency, suggesting that nonsecreting microadenomas may not be clinically harmless.	Arginine	131-139	growth hormone releasing hormone	Homo sapiens	126-130
18636161-7	2008	Expression of the Bcl-xL mutant, in which alanine was substituted for both arginine 52 and 66 (N52,66A-Bcl-xL), suppressed deamidation and showed resistance to the induction of apoptosis by treatment with GSH-DXR.	Arginine	75-83	BCL2 like 1	Homo sapiens	18-24
18499668-8	2008	Further, degradation of E14Q-HD5 by trypsin was initiated by the cleavage of the Arg(13)-Gln(14) peptide bond in the loop region, a catastrophic proteolytic event resulting directly in quick digestion of the whole defensin molecule.	Arginine	81-84	defensin alpha 5	Homo sapiens	29-32
18537053-4	2008	Vasoreactivity induced by L-arginine, which is the substrate for endothelial nitric oxide synthase, is a parameter of endothelial function and has been shown to be altered in patients with cerebrovascular disease.	Arginine	26-36	nitric oxide synthase 3	Homo sapiens	65-98
18505818-1	2008	Histone Arg methylation has been correlated with transcriptional activation of p53 target genes.	Arginine	8-11	tumor protein p53	Homo sapiens	79-82
18028947-1	2008	BACKGROUND: l-arginine transport mediated by type-2 cationic amino acid transporter (CAT-2) isozymes is one crucial mechanism that regulates nitric oxide (NO) production via inducible nitric oxide synthase (iNOS).	Arginine	12-22	nitric oxide synthase 2	Rattus norvegicus	174-205
18028947-1	2008	BACKGROUND: l-arginine transport mediated by type-2 cationic amino acid transporter (CAT-2) isozymes is one crucial mechanism that regulates nitric oxide (NO) production via inducible nitric oxide synthase (iNOS).	Arginine	12-22	nitric oxide synthase 2	Rattus norvegicus	207-211
18554632-1	2008	PURPOSE: Previously we found that the trophinin-binding peptide GWRQ (glycine, tryptophane, arginine, glutamic acid) activated human trophoblastic cells.	Arginine	92-100	trophinin	Homo sapiens	38-47
18625332-1	2008	Arginine is a common substrate for both inducible nitric oxide synthase (iNOS) and arginase.	Arginine	0-8	nitric oxide synthase 2, inducible	Mus musculus	40-71
18625332-1	2008	Arginine is a common substrate for both inducible nitric oxide synthase (iNOS) and arginase.	Arginine	0-8	nitric oxide synthase 2, inducible	Mus musculus	73-77
18625332-2	2008	The competition between iNOS and arginase for arginine contributes to the outcome of several parasitic and bacterial infections.	Arginine	46-54	nitric oxide synthase 2, inducible	Mus musculus	24-28
18625332-6	2008	Blocking arginase increases the substrate l-arginine availability to iNOS for production of more nitric oxide and perhaps peroxynitrite molecules in the infected cells allowing better killing of virulent Salmonella in a NO dependent manner.	Arginine	42-52	nitric oxide synthase 2, inducible	Mus musculus	69-73
18505818-10	2008	At early time points after UV treatment, an increase of histone Arg methylation and a decrease of citrullination were correlated with a transient activation of p21.	Arginine	64-67	cyclin dependent kinase inhibitor 1A	Homo sapiens	160-163
18714441-7	2008	The virus in a freeze dried fibrinogen containing trisodium citrate dihydrate and l-arginine hydrochloride as stabilizers was inactivated slowly and the LRF was 2.0 and 3.0, respectively, of the 72 h at 60 degrees C, but inactivated to below the detection limit within 24 h at 80 degrees C with an LRF of &gt; or = 4.0.	Arginine	82-106	CREB3 regulatory factor	Homo sapiens	153-156
18437360-3	2008	In addition, reduced L-arginine availability to iNOS induced by arginase may result in the synthesis of both NO and the superoxide anion by this enzyme, thereby enhancing the production of peroxynitrite, which has procontractile and pro-inflammatory actions.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	48-52
18439639-10	2008	The concentration of arginine found in isolated airways from Balb/c mice exposed for 2 weeks to ovalbumin was about half of the value found in isolated microdissected airways from normal mice.	Arginine	21-29	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	96-105
18439639-12	2008	Our results are consistent with the hypothesis that the response of the lung to ovalbumin challenge includes an adaptive response in the large airways regulating the concentration of arginine within cells of the airway epithelium and subepithelial layer, by shunting of arginine into the metabolic pathway for increased synthesis of NO.	Arginine	183-191	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	80-89
18439639-12	2008	Our results are consistent with the hypothesis that the response of the lung to ovalbumin challenge includes an adaptive response in the large airways regulating the concentration of arginine within cells of the airway epithelium and subepithelial layer, by shunting of arginine into the metabolic pathway for increased synthesis of NO.	Arginine	270-278	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	80-89
18456371-3	2008	NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys(129)-Arg(130) and Arg(145)-Arg(146) sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated).	Arginine	84-87	pro-melanin concentrating hormone	Homo sapiens	38-41
18456371-3	2008	NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys(129)-Arg(130) and Arg(145)-Arg(146) sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated).	Arginine	97-100	pro-melanin concentrating hormone	Homo sapiens	38-41
18456371-3	2008	NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys(129)-Arg(130) and Arg(145)-Arg(146) sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated).	Arginine	97-100	pro-melanin concentrating hormone	Homo sapiens	38-41
19124426-4	2008	Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation.	Arginine	45-55	nitric oxide synthase 3	Homo sapiens	84-117
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	243-246	insulin like growth factor 1	Homo sapiens	7-12
18597946-10	2008	The Cacna1a(Tg-5J) mutation caused a shift in both voltage activation and inactivation to lower voltages, showing that this arginine residue is critical for sensing Ca(v)2.1 voltage changes.	Arginine	124-132	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	4-11
18597946-10	2008	The Cacna1a(Tg-5J) mutation caused a shift in both voltage activation and inactivation to lower voltages, showing that this arginine residue is critical for sensing Ca(v)2.1 voltage changes.	Arginine	124-132	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	165-173
18492485-1	2008	Insulin signaling in skeletal L6 myotubes is known to be affected by arginine methylation catalyzed by protein N-arginine methyltransferase 1 (PRMT1), however, the mechanism by which this occurs has not yet been defined.	Arginine	69-77	insulin	Homo sapiens	0-7
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	243-246	insulin	Homo sapiens	72-79
18492485-3	2008	Insulin enhanced arginine methylation of a 66-kDa protein (p66) concomitant with translocation of PRMT1 to the membrane fraction.	Arginine	17-25	insulin	Homo sapiens	0-7
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	243-246	insulin like growth factor 1	Homo sapiens	129-134
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	243-246	insulin like growth factor 1	Homo sapiens	129-134
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	252-255	insulin like growth factor 1	Homo sapiens	7-12
18555215-11	2008	L-arginine reversed the inhibited relaxation responses to acetylcholine in the IL-6-treated strips.	Arginine	0-10	interleukin 6	Rattus norvegicus	79-83
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	252-255	insulin	Homo sapiens	72-79
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	252-255	insulin like growth factor 1	Homo sapiens	129-134
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	252-255	insulin like growth factor 1	Homo sapiens	129-134
18546299-0	2008	The accuracy of the arginine growth hormone test in Parkinsonism.	Arginine	20-28	growth hormone 1	Homo sapiens	29-43
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	56-64	estrogen receptor 1	Homo sapiens	29-36
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	56-64	estrogen receptor 1	Homo sapiens	140-147
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	116-124	estrogen receptor 1	Homo sapiens	29-36
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	116-124	estrogen receptor 1	Homo sapiens	140-147
18450754-6	2008	The resonance Raman results revealed significant interactions of Arg-97 and Phe-113 with a ligand bound to the sixth coordination site of the heme and profound structural changes in the heme propionates upon dissociation of CO. Mutation of Phe-113 perturbed the PDE activities, and the mutation of Arg-97 and Phe-113 significantly influenced the transient binding of Met-95 to the heme upon photodissociation of CO.	Arginine	65-68	phosphodiesterase	Escherichia coli	262-265
18448590-1	2008	A mutation in the human FXYD2 polypeptide (Na-K-ATPase gamma subunit) that changes a conserved transmembrane glycine to arginine is linked to dominant renal hypomagnesemia.	Arginine	120-128	FXYD domain containing ion transport regulator 2	Homo sapiens	24-29
18495509-11	2008	These results provide insight into the role of the cCAT-2 gene and its regulation of lysine and arginine utilization in aves.	Arginine	96-104	solute carrier family 7 member 2	Gallus gallus	51-57
18456737-4	2008	Arginine treatment of BERK mice (5% arginine in mouse chow for 15 days) significantly reduced expression of non-NO vasodilators COX-2 and heme oxygenase-1.	Arginine	0-8	heme oxygenase 1	Mus musculus	138-154
18456737-4	2008	Arginine treatment of BERK mice (5% arginine in mouse chow for 15 days) significantly reduced expression of non-NO vasodilators COX-2 and heme oxygenase-1.	Arginine	36-44	heme oxygenase 1	Mus musculus	138-154
18331270-16	2008	VEGF and cGMP levels in the L-arg + vardenafil-treated group were significantly greater than those in the L-arg-treated group and the control group.	Arginine	28-33	vascular endothelial growth factor A	Homo sapiens	0-4
18445664-0	2008	Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women.	Arginine	62-70	growth hormone releasing hormone	Homo sapiens	29-61
18567752-6	2008	Dietary supplementation with 0.7% L-arginine also increased (P &lt; 0.05) immunoreactive expression of CD34 in duodenal submucosa, ileal mucosa and submucosa, and expression of vascular endothelial growth factor (VEGF) in duodenal submucosa, jejunal mucosa and submucosa, and ileal mucosa compared with the control and 1.2% L-arginine supplementation.	Arginine	34-44	CD34 molecule	Sus scrofa	103-107
18436584-6	2008	LAP has a basic, arginine-rich C-terminal motif similar to VEGF and peptides that bind to the b1 domain of Nrp1.	Arginine	17-25	transforming growth factor beta 1	Homo sapiens	0-3
18331270-3	2008	L-arginine (L-arg), the precursor of NO, and selective phosphodiesterase type 5 (PDE-5) inhibitors that increase levels of intracellular cGMP may complementarily enhance VEGF synthesis in corpus cavernosal smooth muscle cells (CCSMCs), and may consequently restore impaired endothelial function.	Arginine	0-10	vascular endothelial growth factor A	Homo sapiens	170-174
18331270-3	2008	L-arginine (L-arg), the precursor of NO, and selective phosphodiesterase type 5 (PDE-5) inhibitors that increase levels of intracellular cGMP may complementarily enhance VEGF synthesis in corpus cavernosal smooth muscle cells (CCSMCs), and may consequently restore impaired endothelial function.	Arginine	0-5	vascular endothelial growth factor A	Homo sapiens	170-174
18331270-19	2008	Combined L-arg and vardenafil treatment, which can enhance VEGF production, may provide a novel therapeutic strategy for the treatment of erectile dysfunction as well as endothelial dysfunction in general.	Arginine	9-14	vascular endothelial growth factor A	Homo sapiens	59-63
18331270-15	2008	VEGF and cGMP levels in the L-arg-treated group were also significantly greater than those in the control group.	Arginine	28-33	vascular endothelial growth factor A	Homo sapiens	0-4
18397234-4	2008	METHODS: We studied a total of nine polymorphisms of the IRF-7 gene including SNP1047A/G (Lys/Glu) and SNP2157A/G (Gln/Arg) using the Taqman allelic discrimination and sequencing techniques in 406 Japanese patients with chronic HCV infection.	Arginine	119-122	interferon regulatory factor 7	Homo sapiens	57-62
18596315-2	2008	We have previously demonstrated that MMP-2 expression correlates with increased inducible nitric oxide synthase (iNOS) production in the stomach and that iNOS is upregulated in the postischemic gut by the luminal nutrient arginine and repressed by luminal glutamine.	Arginine	222-230	nitric oxide synthase 2	Rattus norvegicus	154-158
18596315-8	2008	Pretreatment of the arginine group with a selective iNOS inhibitor blunted the induction of MMP-2 in the postischemic gut.	Arginine	20-28	nitric oxide synthase 2	Rattus norvegicus	52-56
18596315-10	2008	CONCLUSIONS: The arginine-induced upregulation of iNOS may contribute to increased activity of MT1-MMP and MMP-2.	Arginine	17-25	nitric oxide synthase 2	Rattus norvegicus	50-54
18358546-0	2008	The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor.	Arginine	75-83	arginine vasopressin receptor 2	Homo sapiens	99-122
19035188-7	2008	CONCLUSION: The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.	Arginine	47-50	thioredoxin reductase 2	Homo sapiens	37-43
18560723-8	2008	The results showed that AVP stimulated DNA synthesis in adult rat CFs, and the effect was abolished by a V1 receptor antagonist, d(CH(2))(5)[Tyr(2)(Me), Arg(8)]-vasopressin (0.1 mumol/L), but not by a V2 receptor antagonist, desglycinamide-[d(CH(2))(5), D-Ile(2), Ile(4), Arg8]-vasopressin (0.1 mumol/L).	Arginine	153-156	arginine vasopressin	Rattus norvegicus	24-27
18560723-8	2008	The results showed that AVP stimulated DNA synthesis in adult rat CFs, and the effect was abolished by a V1 receptor antagonist, d(CH(2))(5)[Tyr(2)(Me), Arg(8)]-vasopressin (0.1 mumol/L), but not by a V2 receptor antagonist, desglycinamide-[d(CH(2))(5), D-Ile(2), Ile(4), Arg8]-vasopressin (0.1 mumol/L).	Arginine	153-156	arginine vasopressin	Rattus norvegicus	161-172
18523251-8	2008	A mutant HIV-1 provirion NL4-3 with a single arginine substitution in Nef at K144 was also inactive in Nef-mediated CD4 down-regulation.	Arginine	45-53	S100 calcium binding protein B	Homo sapiens	70-73
18424440-2	2008	Additionally, factor VIIIa is cleaved by the anticoagulant serine protease, activated protein C, at two cleavage sites, Arg(336) in the A1 subunit and Arg(562) in the A2 subunit.	Arginine	120-123	coagulation factor II, thrombin	Homo sapiens	59-74
18424440-2	2008	Additionally, factor VIIIa is cleaved by the anticoagulant serine protease, activated protein C, at two cleavage sites, Arg(336) in the A1 subunit and Arg(562) in the A2 subunit.	Arginine	151-154	coagulation factor II, thrombin	Homo sapiens	59-74
17588688-1	2008	BACKGROUND: L-arginine, the substrate for endothelial nitric oxide synthase, is essential for normal endothelial function.	Arginine	12-22	nitric oxide synthase 3	Homo sapiens	42-75
18249029-0	2008	Arsenic-induced health effects and genetic damage in keratotic individuals: involvement of p53 arginine variant and chromosomal aberrations in arsenic susceptibility.	Arginine	95-103	tumor protein p53	Homo sapiens	91-94
18249029-6	2008	Previously we have reported that the p53 codon 72 arginine (Arg) homozygous genotype is associated with the development of arsenic-induced keratosis.	Arginine	50-58	tumor protein p53	Homo sapiens	37-40
18249029-6	2008	Previously we have reported that the p53 codon 72 arginine (Arg) homozygous genotype is associated with the development of arsenic-induced keratosis.	Arginine	60-63	tumor protein p53	Homo sapiens	37-40
18249029-13	2008	This study suggests that individuals with keratosis are more susceptible to arsenic-induced health effects and genetic damage and that the arginine variant of p53 can further influence the repair capacity of arsenic-exposed individuals, leading to increased accumulation of chromosomal aberrations.	Arginine	139-147	tumor protein p53	Homo sapiens	159-162
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	80-83	coagulation factor II, thrombin	Homo sapiens	123-131
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	80-83	coagulation factor II, thrombin	Homo sapiens	252-260
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	80-83	coagulation factor II, thrombin	Homo sapiens	262-265
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	88-91	coagulation factor II, thrombin	Homo sapiens	123-131
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	88-91	coagulation factor II, thrombin	Homo sapiens	252-260
18585267-1	2008	By designing and coupling a functional peptide, Gly-Leu-Ala-Cys-Ser-Gly-Phe-Pro-Arg-Gly-Arg-Trp, which could be cleaved by thrombin at the site of Arg-Gly (R-G), to the surface of gold nanoparticles (Au-NPs), we propose a simple spectrofluorometry for thrombin (TRB) in this contribution.	Arginine	88-91	coagulation factor II, thrombin	Homo sapiens	262-265
18495154-6	2008	Here, we present the solution structure of the inner DysF domain of the dysferlin paralogue myoferlin, which has a unique fold held together by stacking of arginine and tryptophans, mutations that lead to clinical disease in dysferlin.	Arginine	156-164	dysferlin	Homo sapiens	72-81
18495154-6	2008	Here, we present the solution structure of the inner DysF domain of the dysferlin paralogue myoferlin, which has a unique fold held together by stacking of arginine and tryptophans, mutations that lead to clinical disease in dysferlin.	Arginine	156-164	myoferlin	Homo sapiens	92-101
18495154-6	2008	Here, we present the solution structure of the inner DysF domain of the dysferlin paralogue myoferlin, which has a unique fold held together by stacking of arginine and tryptophans, mutations that lead to clinical disease in dysferlin.	Arginine	156-164	dysferlin	Homo sapiens	225-234
20641421-4	2004	VIP (HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2) is a hydrophobic, basic peptide that contains three lysine residues (1520, and 21, ), two arginine residues (12 and 14, ), two tyrosine residues (10 and 22, ), an essential histidine residue at the N terminus, and an amidated C-terminus (10).	Arginine	129-137	vasoactive intestinal peptide	Homo sapiens	0-3
18358546-4	2008	Then, construction of a mutant receptor in i3 loop allowed us to identify the i3 loop arginine cluster of the vasopressin V(2) receptor as the interacting determinant for GC1q-R interaction.	Arginine	86-94	arginine vasopressin receptor 2	Homo sapiens	110-135
18505839-2	2008	Here, we demonstrate that PDGF-induced activation of a PDGFRbeta mutated in Arg-385 or Glu-390 in D4 (the fourth Ig-like domain of the extracellular region) was compromised, resulting in impairment of a variety of PDGF-induced cellular responses.	Arginine	76-79	platelet derived growth factor receptor beta	Homo sapiens	55-64
18457426-1	2008	Structural and mutagenesis data have indicated that the 220-loop of thrombin is stabilized by a salt-bridge between Glu-217 and Lys-224, thereby facilitating the octahedral coordination of Na (+) with contributions from two carbonyl O atoms of Arg-221a and Lys-224.	Arginine	244-247	coagulation factor II, thrombin	Homo sapiens	68-76
18505839-3	2008	These experiments demonstrate that homotypic D4 interactions probably mediated by salt bridges between Arg-385 and Glu-390 play an important role in activation of PDGFRbeta and all type III receptor tyrosine kinases.	Arginine	103-106	platelet derived growth factor receptor beta	Homo sapiens	163-172
18954551-5	2008	Only three from the eight TP53 polymorphisms described in the analyzed region were polymorphic within our samples: the 11827 base from intron 2, the 16bp duplication in the intron3 and the codon 72 (Arg&gt;Pro) from exon 4.	Arginine	199-202	tumor protein p53	Homo sapiens	26-30
18422998-4	2008	Plasma fibronectin (Fn), a ligand for alpha4beta1, could link SS RBCs to monocytes, as peptides derived from both the Arg-Gly-Asp-Ser (RGDS) and CS-1 site in Fn disrupted the reticulocyte/monocyte interaction.	Arginine	118-121	fibronectin 1	Homo sapiens	7-18
18422998-4	2008	Plasma fibronectin (Fn), a ligand for alpha4beta1, could link SS RBCs to monocytes, as peptides derived from both the Arg-Gly-Asp-Ser (RGDS) and CS-1 site in Fn disrupted the reticulocyte/monocyte interaction.	Arginine	118-121	fibronectin 1	Homo sapiens	20-22
18472002-0	2008	Arginine methylation of hnRNP K enhances p53 transcriptional activity.	Arginine	0-8	tumor protein p53	Homo sapiens	41-44
18437349-4	2008	Insulin secretion was evaluated as the insulin response to intravenous arginine (5 g) injected at fasting glucose and after raising glucose to 13 to 15 mmol/l or to &gt;28 mmol/l.	Arginine	71-79	insulin	Homo sapiens	0-7
18437349-4	2008	Insulin secretion was evaluated as the insulin response to intravenous arginine (5 g) injected at fasting glucose and after raising glucose to 13 to 15 mmol/l or to &gt;28 mmol/l.	Arginine	71-79	insulin	Homo sapiens	39-46
18437349-8	2008	During dexamethasone-induced insulin resistance, trimethaphan reduced the insulin response to arginine at all three glucose levels.	Arginine	94-102	insulin	Homo sapiens	74-81
18504314-4	2008	Here we investigate the proximity of S4 and the pore domain in functional Kv1.2 channels in a native membrane environment using electrophysiological analysis of intersubunit histidine metallic bridges formed between the first arginine of S4 (R294) and residues A351 or D352 of the pore domain.	Arginine	226-234	potassium voltage-gated channel subfamily A member 2	Homo sapiens	74-79
18437349-9	2008	The augmentation of the arginine-induced insulin responses by dexamethasone-induced insulin resistance was reduced by trimethaphan by 48+/-6% at fasting glucose, 61+/-8% at 13-15 mmol/l glucose and 62+/-8% at &gt;28 mmol/l glucose (p&lt;0.001 for all).	Arginine	24-32	insulin	Homo sapiens	41-48
18437349-9	2008	The augmentation of the arginine-induced insulin responses by dexamethasone-induced insulin resistance was reduced by trimethaphan by 48+/-6% at fasting glucose, 61+/-8% at 13-15 mmol/l glucose and 62+/-8% at &gt;28 mmol/l glucose (p&lt;0.001 for all).	Arginine	24-32	insulin	Homo sapiens	84-91
26621242-7	2008	Hydrogen bonding interactions were observed between the atRA carboxylate group and Arg 90 in CYP26A1 and with Arg76, Arg95, and Ser369 in CYP26B1.	Arginine	83-86	cytochrome P450 family 26 subfamily A member 1	Homo sapiens	93-100
18472002-1	2008	Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53.	Arginine	77-85	tumor protein p53	Homo sapiens	187-190
18472002-3	2008	Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53.	Arginine	13-21	tumor protein p53	Homo sapiens	72-75
18472002-5	2008	These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.	Arginine	26-34	tumor protein p53	Homo sapiens	79-82
18332147-9	2008	By mutational analysis, we demonstrate, for the first time, that nuclear translocation occurs via nuclear localization signal (NLS) within residues Arg(471)-Lys(472) in CRMP2 sequence.	Arginine	148-151	dihydropyrimidinase like 2	Homo sapiens	169-174
18501011-7	2008	L-arginine and nifedipine blocked the effects of angiotensin II.	Arginine	0-10	angiotensinogen	Homo sapiens	49-63
18234834-1	2008	It has been found that with mutation of two surface residues (Lys(22) --&gt; Glu and His(104) --&gt; Arg) in human purine nucleoside phosphorylase (hPNP), there is an enhancement of catalytic activity in the chemical step.	Arginine	101-104	purine nucleoside phosphorylase	Homo sapiens	115-146
17997414-1	2008	BACKGROUND: Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS).	Arginine	25-33	nitric oxide synthase 2	Rattus norvegicus	145-149
17997414-10	2008	CONCLUSION: It is demonstrated that administration of arginine together with the selective iNOS inhibitor in the early phase of sepsis restores plasma arginine, reduces oxidative stress by probably maintaining NO derived from constitutive NOS, and attenuates neuroendocrine stress responses.	Arginine	151-159	nitric oxide synthase 2	Rattus norvegicus	91-95
18480736-10	2008	Arginase isoenzymes AI and AII have high substrate specifi city, but the affi nity to L-arginine is higher for isoenzyme AI than AII.	Arginine	86-96	NLR family pyrin domain containing 3	Homo sapiens	27-30
18480736-10	2008	Arginase isoenzymes AI and AII have high substrate specifi city, but the affi nity to L-arginine is higher for isoenzyme AI than AII.	Arginine	86-96	NLR family pyrin domain containing 3	Homo sapiens	129-132
18480737-6	2008	The competition of arginase with nitric oxide synthase (NOS) for the common substrate L-arginine indicates its participation in the regulation of nitric oxide (NO) synthesis.	Arginine	86-96	nitric oxide synthase 2	Homo sapiens	33-54
18631967-3	2008	METHODS: We analyzed Arg-61 apoE mice, a gene-targeted model that selectively displays domain interaction.	Arginine	21-24	apolipoprotein E	Mus musculus	28-32
18631967-9	2008	Consistent with the reduced secretion of Arg-61 apoE by astrocytes in this model, cholesterol secretion was also reduced 34%.	Arginine	41-44	apolipoprotein E	Mus musculus	48-52
18353876-0	2008	L-arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG II.	Arginine	0-10	insulin	Homo sapiens	69-76
18353876-3	2008	ARG infusion increased GFR, while increasing insulin levels.	Arginine	0-3	insulin	Homo sapiens	45-52
18353876-4	2008	OCT coinfusion prevented this increase in GFR, but with insulin infusion to duplicate ARG induced rise in insulin, the GFR response was restored.	Arginine	86-89	insulin	Homo sapiens	56-63
18353876-8	2008	In conclusion, 1) hyperfiltration responses to ARG require the concurrent, modest, permissive increase in insulin; 2) inhibition of insulin release after ARG reduces proximal reabsorption and prevents the hyperfiltration response; and 3) inhibition of ANG II activity restores the hyperfiltration response, maintains parallel increases in proximal reabsorption, and overrides the arginine/octreotide actions.	Arginine	47-50	insulin	Homo sapiens	106-113
18353876-8	2008	In conclusion, 1) hyperfiltration responses to ARG require the concurrent, modest, permissive increase in insulin; 2) inhibition of insulin release after ARG reduces proximal reabsorption and prevents the hyperfiltration response; and 3) inhibition of ANG II activity restores the hyperfiltration response, maintains parallel increases in proximal reabsorption, and overrides the arginine/octreotide actions.	Arginine	47-50	insulin	Homo sapiens	132-139
18353876-8	2008	In conclusion, 1) hyperfiltration responses to ARG require the concurrent, modest, permissive increase in insulin; 2) inhibition of insulin release after ARG reduces proximal reabsorption and prevents the hyperfiltration response; and 3) inhibition of ANG II activity restores the hyperfiltration response, maintains parallel increases in proximal reabsorption, and overrides the arginine/octreotide actions.	Arginine	154-157	insulin	Homo sapiens	132-139
18353876-8	2008	In conclusion, 1) hyperfiltration responses to ARG require the concurrent, modest, permissive increase in insulin; 2) inhibition of insulin release after ARG reduces proximal reabsorption and prevents the hyperfiltration response; and 3) inhibition of ANG II activity restores the hyperfiltration response, maintains parallel increases in proximal reabsorption, and overrides the arginine/octreotide actions.	Arginine	380-388	insulin	Homo sapiens	132-139
18385254-0	2008	Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop.	Arginine	113-121	CD4 molecule	Homo sapiens	65-68
18249022-7	2008	However, the Arg-allele was associated with a slightly increased risk of type 2 diabetes (OR1.15 (CI: 1.01-1.31); p=0.04), increased insulin resistance estimated by homeostasis model assessment (p=0.01), higher fasting serum insulin levels (p=0.01), and higher levels of plasma glucose 2-h after glucose ingestion (p=0.02).	Arginine	13-16	insulin	Homo sapiens	133-140
18630481-8	2008	In patients with GSTM1 null genotype and p53 Arg/Pro heterozygotes or Pro/Pro homozygotes the chance of survival is significantly lower than in the case of GSTM1+ and p53 Arg/Arg variants (p=0.009 and p=0.008, respectively).	Arginine	45-48	tumor protein p53	Homo sapiens	41-44
18630481-8	2008	In patients with GSTM1 null genotype and p53 Arg/Pro heterozygotes or Pro/Pro homozygotes the chance of survival is significantly lower than in the case of GSTM1+ and p53 Arg/Arg variants (p=0.009 and p=0.008, respectively).	Arginine	171-174	glutathione S-transferase mu 1	Homo sapiens	17-22
18630481-8	2008	In patients with GSTM1 null genotype and p53 Arg/Pro heterozygotes or Pro/Pro homozygotes the chance of survival is significantly lower than in the case of GSTM1+ and p53 Arg/Arg variants (p=0.009 and p=0.008, respectively).	Arginine	171-174	tumor protein p53	Homo sapiens	167-170
18630481-8	2008	In patients with GSTM1 null genotype and p53 Arg/Pro heterozygotes or Pro/Pro homozygotes the chance of survival is significantly lower than in the case of GSTM1+ and p53 Arg/Arg variants (p=0.009 and p=0.008, respectively).	Arginine	171-174	glutathione S-transferase mu 1	Homo sapiens	17-22
18630481-8	2008	In patients with GSTM1 null genotype and p53 Arg/Pro heterozygotes or Pro/Pro homozygotes the chance of survival is significantly lower than in the case of GSTM1+ and p53 Arg/Arg variants (p=0.009 and p=0.008, respectively).	Arginine	171-174	tumor protein p53	Homo sapiens	167-170
18508690-7	2008	On the surface of T cells, ART2.2 ADP-ribosylates the P2X7 purinoceptor on arginine 125, thereby gating the P2X7 ion channel by presenting a ligand to its nucleotide-binding site.	Arginine	75-83	purinergic receptor P2X 7	Homo sapiens	54-58
18508690-7	2008	On the surface of T cells, ART2.2 ADP-ribosylates the P2X7 purinoceptor on arginine 125, thereby gating the P2X7 ion channel by presenting a ligand to its nucleotide-binding site.	Arginine	75-83	purinergic receptor P2X 7	Homo sapiens	108-112
18424242-1	2008	The N-terminus of the trimeric TNF-alpha molecule comprises two basic arginines within the short amino-acid sequence VRSSSR, which is here shown to be essential for binding of TNF-alpha to heparin-Sepharose.	Arginine	70-79	tumor necrosis factor	Homo sapiens	31-40
18424242-1	2008	The N-terminus of the trimeric TNF-alpha molecule comprises two basic arginines within the short amino-acid sequence VRSSSR, which is here shown to be essential for binding of TNF-alpha to heparin-Sepharose.	Arginine	70-79	tumor necrosis factor	Homo sapiens	176-185
18424593-0	2008	Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs.	Arginine	8-16	mechanistic target of rapamycin kinase	Sus scrofa	43-47
18424593-8	2008	These changes were associated with elevated levels of phosphorylated mTOR and 4E-BP1 in muscle of arginine-supplemented piglets (P &lt; 0.05).	Arginine	98-106	mechanistic target of rapamycin kinase	Sus scrofa	69-73
18424593-10	2008	Collectively, these results suggest that dietary arginine supplementation increases mTOR signaling activity in skeletal muscle, but not in liver, of milk-fed neonatal pigs.	Arginine	49-57	mechanistic target of rapamycin kinase	Sus scrofa	84-88
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	149-152	component of oligomeric golgi complex 2	Homo sapiens	104-119
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	149-152	component of oligomeric golgi complex 2	Homo sapiens	121-126
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	153-156	component of oligomeric golgi complex 2	Homo sapiens	104-119
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	153-156	component of oligomeric golgi complex 2	Homo sapiens	121-126
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	153-156	component of oligomeric golgi complex 2	Homo sapiens	104-119
18482921-5	2008	When subjects were divided into three groups according to the genotype, a significant increase of serum LDL-cholesterol (LDL-C) concentration in the Arg/Arg group (3.48 +/- 1.59 mmol/L) was observed when compared with those of the Trp/Trp and Arg/Trp groups (3.15 +/- 0.80, 3.25 +/- 0.92 mmol/L, respectively).	Arginine	153-156	component of oligomeric golgi complex 2	Homo sapiens	121-126
18482921-7	2008	Spearman"s rank correlation demonstrated a significant relationship between LDL-C concentrations and the number of Arg alleles, age and BMI.	Arginine	115-118	component of oligomeric golgi complex 2	Homo sapiens	76-81
18482921-8	2008	Multiple regression analysis, using LDL-C concentration as a criterion variable and some factors including beta(3)-AR gene polymorphism as explanatory variables, revealed that the number of Arg alleles was a significant and independent factor for LDL-C concentrations, along with age and BMI.	Arginine	190-193	component of oligomeric golgi complex 2	Homo sapiens	247-252
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	209-212	component of oligomeric golgi complex 2	Homo sapiens	179-184
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	213-216	component of oligomeric golgi complex 2	Homo sapiens	179-184
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	213-216	component of oligomeric golgi complex 2	Homo sapiens	179-184
18473302-2	2008	NO is produced from L-arginine by nitric oxide synthase (NOS).	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	34-55
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Arginine	15-18	tumor protein p53	Homo sapiens	3-6
18285453-0	2008	A glycine-arginine domain in control of the human MRE11 DNA repair protein.	Arginine	10-18	MRE11 homolog, double strand break repair nuclease	Homo sapiens	50-55
18285453-2	2008	Human MRE11 bears a glycine-arginine-rich (GAR) motif that is conserved among multicellular eukaryotic species.	Arginine	28-36	MRE11 homolog, double strand break repair nuclease	Homo sapiens	6-11
18285453-5	2008	We demonstrate that PRMT1 interacts with MRE11 but not with the MRN complex, suggesting that MRE11 arginine methylation occurs prior to the binding of NBS1 and RAD50.	Arginine	99-107	MRE11 homolog, double strand break repair nuclease	Homo sapiens	93-98
18285453-6	2008	Moreover, the first six methylated arginines are essential for the regulation of MRE11 DNA binding and nuclease activity.	Arginine	35-44	MRE11 homolog, double strand break repair nuclease	Homo sapiens	81-86
18285453-7	2008	The inhibition of arginine methylation leads to a reduction in MRE11 and RAD51 focus formation on a unique double-strand break in vivo.	Arginine	18-26	MRE11 homolog, double strand break repair nuclease	Homo sapiens	63-68
18347055-3	2008	The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180, and arginine substitution of these residues impaired IL-1R/TLR-mediated IRAK-1 ubiquitination, NEMO binding, and NF-kappaB activation.	Arginine	73-81	interleukin 1 receptor type 1	Homo sapiens	122-127
18249022-7	2008	However, the Arg-allele was associated with a slightly increased risk of type 2 diabetes (OR1.15 (CI: 1.01-1.31); p=0.04), increased insulin resistance estimated by homeostasis model assessment (p=0.01), higher fasting serum insulin levels (p=0.01), and higher levels of plasma glucose 2-h after glucose ingestion (p=0.02).	Arginine	13-16	insulin	Homo sapiens	225-232
18280260-8	2008	The interaction between B-cell lymphoma 2 anti-apoptotic members (BcL(2)) and Hsp70 in the presence of L-Arginine and L-NAME, was determined by coimmunoprecipitation.	Arginine	103-113	BCL2, apoptosis regulator	Rattus norvegicus	66-71
18347060-7	2008	The depletion of PRMT5 in p19 cells stimulates E-cadherin expression, and the SNAIL, AJUBA, and PRMT5 ternary complex can be found at the proximal promoter region of the E-cadherin gene, concomitant with increased arginine methylation of histones at the locus.	Arginine	214-222	protein arginine methyltransferase 5	Homo sapiens	17-22
18347060-7	2008	The depletion of PRMT5 in p19 cells stimulates E-cadherin expression, and the SNAIL, AJUBA, and PRMT5 ternary complex can be found at the proximal promoter region of the E-cadherin gene, concomitant with increased arginine methylation of histones at the locus.	Arginine	214-222	snail family transcriptional repressor 1	Homo sapiens	78-83
18347060-7	2008	The depletion of PRMT5 in p19 cells stimulates E-cadherin expression, and the SNAIL, AJUBA, and PRMT5 ternary complex can be found at the proximal promoter region of the E-cadherin gene, concomitant with increased arginine methylation of histones at the locus.	Arginine	214-222	cadherin 1	Homo sapiens	170-180
18280260-9	2008	Binding of BcL(2) and Hsp70 increased after L-Arginine administration.	Arginine	44-54	BCL2, apoptosis regulator	Rattus norvegicus	11-17
18423915-4	2008	A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status.	Arginine	43-46	tumor protein p53	Homo sapiens	16-19
18437083-7	2008	Antagonist treatment led to significantly higher MIF production at 8 and 12 hours after L-arginine injection as compared with the agonist-treated and nontreated groups.	Arginine	88-98	macrophage migration inhibitory factor	Rattus norvegicus	49-52
18423915-4	2008	A G-to-C SNP at p53 codon 72 results in an Arg/Pro polymorphism, which is associated with apoptosis induction potential and p53 mutation status.	Arginine	43-46	tumor protein p53	Homo sapiens	124-127
18423915-7	2008	p53 codon 72 SNP Arg/Arg polymorphism was associated with the progression of OSCC, and the overall (OS) and disease-free survival (DFS) of irradiated patients.	Arginine	17-20	tumor protein p53	Homo sapiens	0-3
18423915-7	2008	p53 codon 72 SNP Arg/Arg polymorphism was associated with the progression of OSCC, and the overall (OS) and disease-free survival (DFS) of irradiated patients.	Arginine	21-24	tumor protein p53	Homo sapiens	0-3
18423915-9	2008	The combination of MDM2 SNP309 G/G and p53 codon 72 Arg/Arg polymorphism is associated with the worst OS and DFS.	Arginine	52-55	tumor protein p53	Homo sapiens	39-42
18423915-9	2008	The combination of MDM2 SNP309 G/G and p53 codon 72 Arg/Arg polymorphism is associated with the worst OS and DFS.	Arginine	56-59	tumor protein p53	Homo sapiens	39-42
18304667-4	2008	Calculation of the variation in electrostatic free energy with pH indicated that deprotonation of Tyr, Lys and Arg side-chains at high pH would destabilize PrtG.	Arginine	111-114	protogenin	Homo sapiens	156-160
18283102-1	2008	Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor.	Arginine	104-112	nitric oxide synthase 2	Homo sapiens	0-22
18283102-1	2008	Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor.	Arginine	114-117	nitric oxide synthase 2	Homo sapiens	0-22
18413774-7	2008	Females with the HER-1 497 Arg/Arg variant had better overall survival (OS) when compared with the Lys/Lys and/or Lys/Arg variants.	Arginine	27-30	epidermal growth factor receptor	Homo sapiens	17-22
17998932-1	2008	Codon 72 of human p53 gene is polymorphic, encoding arginine or proline.	Arginine	52-60	tumor protein p53	Homo sapiens	18-21
18413774-7	2008	Females with the HER-1 497 Arg/Arg variant had better overall survival (OS) when compared with the Lys/Lys and/or Lys/Arg variants.	Arginine	31-34	epidermal growth factor receptor	Homo sapiens	17-22
18413774-7	2008	Females with the HER-1 497 Arg/Arg variant had better overall survival (OS) when compared with the Lys/Lys and/or Lys/Arg variants.	Arginine	31-34	epidermal growth factor receptor	Homo sapiens	17-22
18468205-1	2008	OBJECTIVE: Nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (NOS3).	Arginine	49-59	nitric oxide synthase 3	Homo sapiens	98-102
18339322-3	2008	The peptide pyro glutamic acid (pGlu)-Arg-Glu-Arg-Tyr-NH2 (pERERY-NH(2)) shares the same binding site with SRSRY and competes with N-formyl-Met-Leu-Phe (fMLF) for binding to the G-protein-coupled N-formyl-peptide receptor (FPR).	Arginine	38-41	formyl peptide receptor 1	Homo sapiens	196-221
18339322-3	2008	The peptide pyro glutamic acid (pGlu)-Arg-Glu-Arg-Tyr-NH2 (pERERY-NH(2)) shares the same binding site with SRSRY and competes with N-formyl-Met-Leu-Phe (fMLF) for binding to the G-protein-coupled N-formyl-peptide receptor (FPR).	Arginine	38-41	formyl peptide receptor 1	Homo sapiens	223-226
18263580-1	2008	Human protein arginine N-methyltransferase 6 (PRMT6) transfers methyl groups from the co-substrate S-adenosyl-L-methionine to arginine residues within proteins, forming S-adenosyl-L-homocysteine as well as omega-N(G)-monomethylarginine (MMA) and asymmetric dimethylarginine (aDMA) residues in the process.	Arginine	14-22	protein arginine methyltransferase 6	Homo sapiens	46-51
18263580-2	2008	We have characterized the kinetic mechanism of recombinant His-tagged PRMT6 using a mass spectrometry method for monitoring the methylation of a series of peptides bearing a single arginine, MMA, or aDMA residue.	Arginine	181-189	protein arginine methyltransferase 6	Homo sapiens	70-75
18311587-10	2008	Cellular and nuclear uptake of the FITC-labelled Apoptin(81-121) peptide was almost completely abolished after altering the NLS2 (replacement of five arginines with serines).	Arginine	150-159	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	49-56
18261179-0	2008	Acute insulin response to arginine in deceased donors predicts the outcome of human islet isolation.	Arginine	26-34	insulin	Homo sapiens	6-13
18261179-2	2008	In this study, we measured acute insulin response to arginine (AIRarg), an in vivo surrogate measure of islet mass, in 29 human deceased donors before organ donation, and correlated values with the outcome of islet isolation.	Arginine	53-61	insulin	Homo sapiens	33-40
18414047-8	2008	An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans.	Arginine	100-108	tumor protein p53	Homo sapiens	60-63
18289863-3	2008	X-ray crystallography discloses that the nitro group well mimics the transition state occurred in the hydrolysis catalyzed by CPA, that is, an O,O"-bidentate coordination to the zinc ion and the two respective hydrogen bonds with Glu-270 and Arg-127.	Arginine	242-245	carboxypeptidase A1	Homo sapiens	126-129
18414047-8	2008	An association has been reported between women carrying the p53 codon 72 polymorphism (a proline to arginine change) with recurrent implantation failure, suggesting a similar function for p53 in humans.	Arginine	100-108	tumor protein p53	Homo sapiens	188-191
18337117-9	2008	CONCLUSION: TGFbeta1 codon 25 genotypes Arg/Pro or Pro/Pro are not associated with alcoholic liver cirrhosis.	Arginine	40-43	transforming growth factor beta 1	Homo sapiens	12-20
18473779-9	2008	It is synthesised from the cationic amino acid L-arginine by a family of enzymes: NO synthases (NOS).	Arginine	47-57	nitric oxide synthase 2	Homo sapiens	82-94
18192540-9	2008	The R46Q substitution changes an invariant arginine residue in position B22, which forms a hydrogen bond with the glutamate at A17, stabilizing the insulin molecule.	Arginine	43-51	insulin	Homo sapiens	148-155
18228201-8	2008	The activity of CuZnSOD is lower in control cold-acclimated rats, as well as in both L-arginine-treated groups, when compared to control animals acclimated to room temperature.	Arginine	85-95	superoxide dismutase 1	Rattus norvegicus	16-23
18380667-3	2008	The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure.	Arginine	65-73	solute carrier family 6 member 8	Rattus norvegicus	223-229
18331355-12	2008	Intriguingly, all polyphenol oxidases, a family of enolases, one transketolase, sulfite reductase, deoxynucleoside kinase-like and dihydroxy-acid dehydrase had twin-arginine translocation motifs, and a homologue to dihydrolipoamide dehydrogenase had a Sec (secretory) motif; these motifs usually target thylakoid-like structures.	Arginine	165-173	transketolase, chloroplastic	Solanum tuberosum	65-78
18094013-8	2008	In contrast, l-arginine concentrations in sputum decreased significantly during growth hormone treatment, as did exhaled nitric oxide levels.	Arginine	13-23	growth hormone 1	Homo sapiens	80-94
18094013-9	2008	Treatment with growth hormone in children with cystic fibrosis decreases exhaled nitric oxide by reducing the concentration of l-arginine in the airways.	Arginine	127-137	growth hormone 1	Homo sapiens	15-29
18194265-6	2008	Strikingly, iNOS-/- and Nitro-Arg-treated mice presented fungal resistance, controlling fungal load in tissues and restoring T-cell activity, as well as producing high amounts of IFN-gamma Interestingly, macrophages from these groups of mice presented fungicidal activity after in vitro stimulation with higher doses of IFN-gamma.	Arginine	30-33	interferon gamma	Mus musculus	179-188
18194265-6	2008	Strikingly, iNOS-/- and Nitro-Arg-treated mice presented fungal resistance, controlling fungal load in tissues and restoring T-cell activity, as well as producing high amounts of IFN-gamma Interestingly, macrophages from these groups of mice presented fungicidal activity after in vitro stimulation with higher doses of IFN-gamma.	Arginine	30-33	interferon gamma	Mus musculus	320-329
18228201-9	2008	L-NAME treatment attenuates the effects both of cold and L-arginine on CuZnSOD and increases immunopositivity for CuZnSOD in room temperature-acclimated rats.	Arginine	57-67	superoxide dismutase 1	Rattus norvegicus	71-78
18042364-6	2008	This region of fibronectin contains the Arg-Gly-Asp sequence recognized by alpha5beta1 integrin, but deletion of that sequence does not prevent TSG-6 binding, and TSG-6 does not inhibit cell adhesion on fibronectin substrates mediated by this integrin.	Arginine	40-43	fibronectin 1	Homo sapiens	15-26
22477366-9	2008	This may be due to the ability of arginine to improve insulin resistance, decrease advanced glycation end products formation, increase nitric oxide, and decrease levels of angiotensin II and oxidative stress, with improved endothelial cell function and decreased peripheral vascular resistance.	Arginine	34-42	insulin	Homo sapiens	54-61
22477366-9	2008	This may be due to the ability of arginine to improve insulin resistance, decrease advanced glycation end products formation, increase nitric oxide, and decrease levels of angiotensin II and oxidative stress, with improved endothelial cell function and decreased peripheral vascular resistance.	Arginine	34-42	angiotensinogen	Homo sapiens	172-186
18272203-2	2008	In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well.	Arginine	50-58	tumor protein p53	Homo sapiens	36-40
18272203-2	2008	In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well.	Arginine	50-53	tumor protein p53	Homo sapiens	36-40
18178668-5	2008	BYK191023-bound iNOS was spectrally indistinguishable from l-arginine-bound iNOS, pointing to an interaction of BYK191023 with the catalytic center of the enzyme.	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	76-80
18328005-0	2008	A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.	Arginine	17-20	solute carrier family 39 member 2	Homo sapiens	8-12
18178668-1	2008	Imidazopyridine derivates were recently shown to be a novel class of selective and arginine-competitive inhibitors of inducible nitric-oxide synthase (iNOS), and 2-[2-(4-methoxypyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) was found to have very high selectivity in enzymatic and cellular models ( Mol Pharmacol 69: 328-337, 2006 ).	Arginine	83-91	nitric oxide synthase 2	Homo sapiens	118-149
18178668-1	2008	Imidazopyridine derivates were recently shown to be a novel class of selective and arginine-competitive inhibitors of inducible nitric-oxide synthase (iNOS), and 2-[2-(4-methoxypyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) was found to have very high selectivity in enzymatic and cellular models ( Mol Pharmacol 69: 328-337, 2006 ).	Arginine	83-91	nitric oxide synthase 2	Homo sapiens	151-155
18495605-5	2008	Specific inhibition of iNOS by the new arginine analog substantially inhibited NO production and increased the peak value of ISO-induced Ca2+ transient.	Arginine	39-47	nitric oxide synthase 2	Rattus norvegicus	23-27
18495605-6	2008	CONCLUSION: The new arginine analog strongly inhibits IL-6 and LPS-induced NO production and increases beta-adrenergic responsiveness in cultured neonatal rat CMs.	Arginine	20-28	interleukin 6	Rattus norvegicus	54-58
18328005-5	2008	In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease.	Arginine	24-27	solute carrier family 39 member 2	Homo sapiens	15-19
18349372-3	2008	In contrast, arginine-specific gingipain 2 (RgpB) increased IL-8 production.	Arginine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
18328005-3	2008	The purpose of this study was to investigate the association of a novel Zip2 Gln/Arg/Leu codon 2 polymorphism with CS, analyzing 250 CS patients and 259 elderly controls.	Arginine	81-84	solute carrier family 39 member 2	Homo sapiens	72-76
18289604-6	2008	Exogenous ADMA significantly enhanced ROS production/MDA concentration and inhibited ALDH-2 activity, and overexpression of DDAH2 could significantly suppress GTN-induced oxidative stress and inhibition of ALDH-2 activity, which is also attenuated by L-arginine.	Arginine	251-261	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	124-129
18756960-10	2008	CONCLUSION: After hemorrhagic shock and resuscitation P-selectin may play an important role in cardiac injury, L-Arg can inhibit the expression of P-selectin, thus protecting the cardiac function against the harmful effect of P-selectin.	Arginine	111-116	selectin P	Rattus norvegicus	147-157
18756960-10	2008	CONCLUSION: After hemorrhagic shock and resuscitation P-selectin may play an important role in cardiac injury, L-Arg can inhibit the expression of P-selectin, thus protecting the cardiac function against the harmful effect of P-selectin.	Arginine	111-116	selectin P	Rattus norvegicus	147-157
18392324-3	2008	In contrast to thrombin, which has a preference toward arginine residues, human neutrophil elastase (HNE) cleaves peptide bonds at small side-chain aliphatic amino acids, preferably at valine.	Arginine	55-63	coagulation factor II, thrombin	Homo sapiens	15-23
17928361-5	2008	We demonstrate that the ecto-enzyme ART2.2 ADP-ribosylates P2X7 at arginine 125 in a prominent, cysteine-rich region at the interface of 2 receptor subunits.	Arginine	67-75	purinergic receptor P2X 7	Homo sapiens	59-63
18369473-1	2008	Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity because they regulate L-arginine availability.	Arginine	112-122	nitric oxide synthase 2, inducible	Mus musculus	67-71
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	AKT serine/threonine kinase 1	Homo sapiens	86-89
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	mitogen-activated protein kinase 1	Homo sapiens	91-94
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	mitogen-activated protein kinase 14	Homo sapiens	157-160
18347314-6	2008	RESULTS: There was a trend toward increased paraoxonase activity in ALS compared with controls (mean control paraoxonase 701.9 +/- 469.7 U/L, mean ALS 792.5 +/- 574.1 U/L; p = 0.066 after correction) which correlated with increased frequency of the homozygous arginine (RR) variant of PON1(Q192R) (p = 0.004).	Arginine	260-268	paraoxonase 1	Homo sapiens	44-55
18328704-4	2008	In this study, we generated mice carrying an identical point mutation to that of the KE family, yielding the equivalent arginine-to-histidine substitution in the Foxp2 DNA-binding domain.	Arginine	120-128	forkhead box P2	Mus musculus	162-167
18029081-0	2008	Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin.	Arginine	96-99	insulin	Homo sapiens	37-44
18029081-3	2008	One such modification viz., an addition of an arginine at the N-terminal A-chain, was reported to possess two-thirds the activity of native insulin.	Arginine	46-54	insulin	Homo sapiens	140-147
18029081-4	2008	The crystal structure of 2 zinc human arg (A0) insulin has been elucidated to 2A resolution to understand the mechanism of reduction in insulin activity.	Arginine	38-41	insulin	Homo sapiens	47-54
18029081-4	2008	The crystal structure of 2 zinc human arg (A0) insulin has been elucidated to 2A resolution to understand the mechanism of reduction in insulin activity.	Arginine	38-41	insulin	Homo sapiens	136-143
18205229-2	2008	The presence of Arg/Arg genotype at codon 72 of TP53 gene was characterized as a risk factor in development of cervical cancer.	Arginine	16-19	tumor protein p53	Homo sapiens	48-52
18205229-2	2008	The presence of Arg/Arg genotype at codon 72 of TP53 gene was characterized as a risk factor in development of cervical cancer.	Arginine	20-23	tumor protein p53	Homo sapiens	48-52
18172012-6	2008	Point mutant analysis revealed that SET domain cysteine 483 and arginine 477 are critical residues for the histone methyltransferase (HMTase) activity of RE-IIBP.	Arginine	64-72	nuclear receptor binding SET domain protein 2	Homo sapiens	154-161
18066713-3	2008	When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner.	Arginine	86-94	interleukin 6	Homo sapiens	136-140
18066713-3	2008	When coincubating A549 with LPS and meta-iodobenzylguanidine or novobiocin, selective arginine-dependent ART-inhibitors, the release of IL-6 and IL-8 was inhibited in a concentration-dependent manner.	Arginine	86-94	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
18421494-0	2008	Mutations at arginine 352 alter the pore architecture of CFTR.	Arginine	13-21	CF transmembrane conductance regulator	Homo sapiens	57-61
18421494-1	2008	Arginine 352 (R352) in the sixth transmembrane domain of the cystic fibrosis transmembrane conductance regulator (CFTR) previously was reported to form an anion/cation selectivity filter and to provide positive charge in the intracellular vestibule.	Arginine	0-8	CF transmembrane conductance regulator	Homo sapiens	61-112
18421494-1	2008	Arginine 352 (R352) in the sixth transmembrane domain of the cystic fibrosis transmembrane conductance regulator (CFTR) previously was reported to form an anion/cation selectivity filter and to provide positive charge in the intracellular vestibule.	Arginine	0-8	CF transmembrane conductance regulator	Homo sapiens	114-118
18063693-4	2008	Arginine substitution of the sumoylatable lysine residue or alanine substitution of a nearby phosphorylatable serine residue (serine 19 in ERRalpha) increased the transcriptional activity of both ERRalpha and -gamma.	Arginine	0-8	estrogen related receptor, alpha	Mus musculus	139-147
18063693-4	2008	Arginine substitution of the sumoylatable lysine residue or alanine substitution of a nearby phosphorylatable serine residue (serine 19 in ERRalpha) increased the transcriptional activity of both ERRalpha and -gamma.	Arginine	0-8	estrogen related receptor, alpha	Mus musculus	196-215
18288414-2	2008	Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid.	Arginine	138-146	tumor protein p53	Homo sapiens	32-35
18313381-3	2008	The data indicate that the high-molecular-weight form of ArgRS, which is present exclusively as an integral component of the multisynthetase complex, is essential for normal protein synthesis and growth of CHO cells even when low-molecular-weight, free ArgRS is present and Arg-tRNA continues to be synthesized at close to wild-type levels.	Arginine	57-60	arginine--tRNA ligase, cytoplasmic	Cricetulus griseus	253-258
18327399-1	2008	Incorporation of factor (F) Va into prothrombinase directs prothrombin activation by FXa through the meizothrombin pathway, characterized by initial cleavage at Arg(320).	Arginine	161-164	coagulation factor II, thrombin	Homo sapiens	36-47
18327399-6	2008	Addition of purified fragment 1 to prethrombin 1 accelerates both the rate of cleavage at Arg(320) and thrombin formation.	Arginine	90-93	coagulation factor II, thrombin	Homo sapiens	38-46
18313381-4	2008	Based on these observations, we conclude that Arg-tRNA generated by the synthetase complex is a more efficient precursor for protein synthesis than Arg-tRNA generated by free ArgRS, exactly as would be predicted by the channeling model for mammalian translation.	Arginine	148-151	arginyl-tRNA synthetase 2, mitochondrial	Homo sapiens	175-180
17998247-4	2008	We report here that KSRP is arginine methylated and interacts with the Tudor domain of SMN, the causative gene for spinal muscular atrophy (SMA), in a CARM1 methylation-dependent fashion.	Arginine	28-36	survival of motor neuron 1, telomeric	Rattus norvegicus	87-90
18029351-7	2008	Incubation of cultured cells with the iNOS substrate L-arginine and NO donor significantly increased cPLA(2)alpha activity and AA release.	Arginine	53-63	nitric oxide synthase 2	Homo sapiens	38-42
18171027-1	2008	Nitric oxide synthase is inhibited by NG-methylated derivatives of arginine whose cellular levels are controlled by dimethylarginine dimethylamino-hydrolase (DDAH).	Arginine	67-75	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	116-156
18171027-1	2008	Nitric oxide synthase is inhibited by NG-methylated derivatives of arginine whose cellular levels are controlled by dimethylarginine dimethylamino-hydrolase (DDAH).	Arginine	67-75	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	158-162
18171027-2	2008	DDAH-1 is a Zn(II)-containing enzyme that through hydrolysis of methylated l-arginines regulates the activity of NOS.	Arginine	75-86	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	0-6
18083711-7	2008	Molecular modeling supports the conclusion that Arg(10) in the D domain of caspase-9 interacts with Asp(160) in the TTCD motif of ERK2.	Arginine	48-51	mitogen-activated protein kinase 1	Homo sapiens	130-134
18164136-0	2008	Effects of l-arginine and N(G)-nitro-l-arginine methyl ester treatments on expression of neuronal nitric oxide synthase in the guinea-pig bladder after partial bladder outlet obstruction.	Arginine	11-21	nitric oxide synthase, brain	Cavia porcellus	89-119
18164136-4	2008	In l-arginine-treated animals killed at 2 and 4 weeks, the total number of nNOS positive intramural neurons was significantly increased when compared with the corresponding control.	Arginine	3-13	nitric oxide synthase, brain	Cavia porcellus	75-79
18081893-1	2008	FVIII is activated by cleavage at Arg(372), Arg(740), and Arg(1689) by thrombin.	Arginine	34-37	coagulation factor II, thrombin	Homo sapiens	71-79
18258526-1	2008	OBJECTIVE: The arginine- to-glutamine change at codon 3500 of the apolipoprotein B-100 (apo B) is a well- known genetic cause of hypercholesterolemia.	Arginine	15-23	apolipoprotein B	Homo sapiens	66-86
18258526-1	2008	OBJECTIVE: The arginine- to-glutamine change at codon 3500 of the apolipoprotein B-100 (apo B) is a well- known genetic cause of hypercholesterolemia.	Arginine	15-23	apolipoprotein B	Homo sapiens	88-93
18258526-4	2008	We aimed to investigate the frequency of apo B-100 mutations (codon 3500) C9774T (Arg 3500--&gt;Trp) and G9775A (Arg 3500--&gt;Gln) in patients with atherosclerosis in comparison with healthy subjects.	Arginine	82-85	apolipoprotein B	Homo sapiens	41-50
18081893-9	2008	These findings demonstrate that clustered basic residues within the 484-509 region of the A2 domain play a part of key role in thrombin-binding, which is responsible for thrombin-catalyzed FVIII activation by cleavage at Arg(372).	Arginine	221-224	coagulation factor II, thrombin	Homo sapiens	127-135
18081893-9	2008	These findings demonstrate that clustered basic residues within the 484-509 region of the A2 domain play a part of key role in thrombin-binding, which is responsible for thrombin-catalyzed FVIII activation by cleavage at Arg(372).	Arginine	221-224	coagulation factor II, thrombin	Homo sapiens	170-178
18201212-0	2008	Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus.	Arginine	88-96	insulin	Homo sapiens	108-115
18201212-4	2008	Arginine-stimulated insulin secretion was measured during a hyperglycaemic clamp (20 mmol/l).	Arginine	0-8	insulin	Homo sapiens	20-27
18201212-8	2008	Arginine-stimulated insulin secretion increased significantly at the two highest dose levels vs. placebo by 114 and 94%, respectively (P &lt; 0.05).	Arginine	0-8	insulin	Homo sapiens	20-27
18201212-10	2008	CONCLUSIONS: Fourteen weeks of treatment with liraglutide showed improvements in first- and second-phase insulin secretion, together with improvements in arginine-stimulated insulin secretion during hyperglycaemia.	Arginine	154-162	insulin	Homo sapiens	174-181
17918207-4	2008	p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects (85.7 vs. 49.6%, P &lt; 0.001), resulting in an elevated ESCC risk (OR = 6.48, 95% CI = 4.65-9.03).	Arginine	4-7	tumor protein p53	Homo sapiens	0-3
17624554-2	2008	Single nucleotide polymorphism (SNP) of arginine (Arg, CGA) or glutamine (Gln, CAA) at codon 302 is known on RAD18; however, the association between the SNP and the risk of any human cancers including non-small-cell lung cancer (NSCLC) has not been reported.	Arginine	40-48	chromogranin A	Homo sapiens	55-58
17991725-7	2008	The efficiency of cleavage at the dibasic Arg(373) downward arrowArg(374) site in synthetic human CgA(360-380) was 3- to 4-fold less in Pro370Leu CgA, compared with the wild type.	Arginine	42-45	chromogranin A	Homo sapiens	98-101
17991725-7	2008	The efficiency of cleavage at the dibasic Arg(373) downward arrowArg(374) site in synthetic human CgA(360-380) was 3- to 4-fold less in Pro370Leu CgA, compared with the wild type.	Arginine	42-45	chromogranin A	Homo sapiens	146-149
18250140-4	2008	Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180-2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752-3.195], P = 0.2328.	Arginine	46-49	tumor protein p53	Homo sapiens	42-45
18250140-4	2008	Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180-2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752-3.195], P = 0.2328.	Arginine	50-53	tumor protein p53	Homo sapiens	42-45
18250140-4	2008	Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180-2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752-3.195], P = 0.2328.	Arginine	50-53	tumor protein p53	Homo sapiens	42-45
18250140-4	2008	Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180-2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752-3.195], P = 0.2328.	Arginine	50-53	tumor protein p53	Homo sapiens	42-45
18250140-4	2008	Odds ratio (OR) for patients with SLE and p53 Arg/Arg genotype was 1.875 [95% CI = 1.180-2.979], P = 0.0075 and OR of the Arg/Arg and Arg/Pro genotypes was 1.549 [95% CI = 0.752-3.195], P = 0.2328.	Arginine	50-53	tumor protein p53	Homo sapiens	42-45
17918207-4	2008	p53 Arg/Arg genotype was significantly increased in ESCC cases compared with control subjects (85.7 vs. 49.6%, P &lt; 0.001), resulting in an elevated ESCC risk (OR = 6.48, 95% CI = 4.65-9.03).	Arginine	8-11	tumor protein p53	Homo sapiens	0-3
17918207-5	2008	In addition, among p53 Arg/Arg carriers, HPV infection, smoking, and drinking might further increase the risk of ESCC development.	Arginine	23-26	tumor protein p53	Homo sapiens	19-22
17918207-5	2008	In addition, among p53 Arg/Arg carriers, HPV infection, smoking, and drinking might further increase the risk of ESCC development.	Arginine	27-30	tumor protein p53	Homo sapiens	19-22
17693925-13	2008	The heatstroke-induced increased levels of IL-1beta and TNF-alpha in the hypothalamus were suppressed by L-arginine treatment.	Arginine	105-115	interleukin 1 beta	Rattus norvegicus	43-51
18175783-2	2008	In sporadic NS, a circulating FSGS-factor is discussed in the pathogenesis and is thought to inhibit the synthesis of nitric oxide (NO) from L-arginine by blocking the NO synthase (NOS).	Arginine	141-151	nitric oxide synthase 2	Homo sapiens	168-179
17693925-13	2008	The heatstroke-induced increased levels of IL-1beta and TNF-alpha in the hypothalamus were suppressed by L-arginine treatment.	Arginine	105-115	tumor necrosis factor	Rattus norvegicus	56-65
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Arginine	229-232	proopiomelanocortin	Homo sapiens	143-179
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	43-46	apolipoprotein B	Homo sapiens	94-101
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	43-46	apolipoprotein B	Homo sapiens	238-245
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	94-101
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	238-245
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	94-101
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	238-245
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	94-101
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein B	Homo sapiens	238-245
18044703-0	2008	The arginine growth hormone stimulation test in bradykinetic-rigid parkinsonisms.	Arginine	4-12	growth hormone 1	Homo sapiens	13-27
18044703-3	2008	We measured the GH response to arginine in serum samples of 26 MSA-P, 23 PSP, and 26 PD patients, and in 80 healthy controls.	Arginine	31-39	growth hormone 1	Homo sapiens	16-18
18044703-9	2008	The GH response to arginine differentiates MSA-P from PD and PSP with a good diagnostic accuracy.	Arginine	19-27	growth hormone 1	Homo sapiens	4-6
18088090-1	2008	A variety of dicarboxylic acid linkers introduced between the alpha-amino group of Pro(6) and the -amino group of Lys(10) of the cyclic lactam alpha-melanocyte-stimulating hormone (alpha-MSH)-derived Pro(6)-D-Phe(7)/D-Nal(2")(7)-Arg(8)-Trp(9)-Lys(10)-NH2 pentapeptide template lead to nanomolar range and selective hMC3R agonists and antagonists.	Arginine	229-232	proopiomelanocortin	Homo sapiens	181-190
18068675-5	2008	Besides the consensus PP1 binding motif, the Arg-motif appears to enhance the interaction between ICP34.5 and PP1.	Arginine	45-48	inorganic pyrophosphatase 1	Homo sapiens	110-113
17618629-5	2008	Similar to the regulation of mammalian insulin, we found that increases of glucose (1-70 mM) and arginine (0.4-25 mM) induced insulin secretion.	Arginine	97-105	insulin	Homo sapiens	39-46
17727676-8	2008	RESULTS: The genotype frequencies of the -75G/A polymorphism of the APOA1 gene were 62.7% GG, 25.7% GA and 11.6% AA, whereas for the Trp64Arg polymorphism of the ADRB3 gene, they were 87.5% Trp/Trp, 11.7% Trp/Arg and 0.8% Arg/Arg.	Arginine	138-141	apolipoprotein A1	Homo sapiens	68-73
18178621-0	2008	Histone arginine methylation is required for vernalization-induced epigenetic silencing of FLC in winter-annual Arabidopsis thaliana.	Arginine	8-16	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	91-94
18178621-7	2008	Furthermore, the levels of arginine methylation of FLC chromatin increase after vernalization.	Arginine	27-35	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	51-54
18178621-8	2008	Therefore, arginine methylation of FLC chromatin is part of the histone code that is required for mitotic stability of the vernalized state.	Arginine	11-19	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	35-38
19025114-6	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	hemolytic complement	Mus musculus	66-69
19025114-6	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	coagulation factor II	Mus musculus	86-94
18189286-6	2008	The p53 residues that are mainly involved in binding to Tat(47-57) are E343 and E349, which bind to the positively charged arginine-rich motif of Tat by a partly electrostatic mechanism.	Arginine	123-131	tumor protein p53	Homo sapiens	4-7
17765926-4	2008	Sequence analysis of TITF-1 revealed the presence of a heterozygous C&gt;T substitution at nucleotide 532, predicted to change an arginine (CGA) with a stop codon (TGA) at position 178 (R178X).	Arginine	130-138	NK2 homeobox 1	Homo sapiens	21-27
18172323-5	2008	Upon estrogen stimulation, the E2F1 promoter is subject to CARM1-dependent dimethylation on histone H3 arginine 17 (H3R17me2) in a process that parallels the recruitment of ER alpha.	Arginine	103-111	estrogen receptor 1	Homo sapiens	173-181
17727676-8	2008	RESULTS: The genotype frequencies of the -75G/A polymorphism of the APOA1 gene were 62.7% GG, 25.7% GA and 11.6% AA, whereas for the Trp64Arg polymorphism of the ADRB3 gene, they were 87.5% Trp/Trp, 11.7% Trp/Arg and 0.8% Arg/Arg.	Arginine	209-212	apolipoprotein A1	Homo sapiens	68-73
17727676-8	2008	RESULTS: The genotype frequencies of the -75G/A polymorphism of the APOA1 gene were 62.7% GG, 25.7% GA and 11.6% AA, whereas for the Trp64Arg polymorphism of the ADRB3 gene, they were 87.5% Trp/Trp, 11.7% Trp/Arg and 0.8% Arg/Arg.	Arginine	209-212	apolipoprotein A1	Homo sapiens	68-73
18090659-2	2008	RECENT FINDINGS: Recent studies have shown that resting growth hormone responses increase with oral ingestion of L-arginine and the dose range is 5-9 g of arginine.	Arginine	115-123	growth hormone 1	Homo sapiens	56-70
18090659-1	2008	PURPOSE OF REVIEW: To describe the effect of an acute bout of exercise on growth hormone responses and to discuss the effect of L-arginine supplementation on growth hormone responses.	Arginine	128-138	growth hormone 1	Homo sapiens	158-172
18090659-2	2008	RECENT FINDINGS: Recent studies have shown that resting growth hormone responses increase with oral ingestion of L-arginine and the dose range is 5-9 g of arginine.	Arginine	113-123	growth hormone 1	Homo sapiens	56-70
18090659-4	2008	Most studies using oral arginine have shown that arginine alone increases the resting growth hormone levels at least 100%, while exercise can increase growth hormone levels by 300-500%.	Arginine	49-57	growth hormone 1	Homo sapiens	86-100
18090659-5	2008	The combination of oral arginine plus exercise attenuates the growth hormone response, however, and only increases growth hormone levels by around 200% compared to resting levels.	Arginine	24-32	growth hormone 1	Homo sapiens	62-76
18090659-5	2008	The combination of oral arginine plus exercise attenuates the growth hormone response, however, and only increases growth hormone levels by around 200% compared to resting levels.	Arginine	24-32	growth hormone 1	Homo sapiens	115-129
18090659-7	2008	At rest oral L-arginine ingestion will enhance the growth hormone response and the combination of arginine plus exercise increases growth hormone, but this increase may be less than seen with exercise alone.	Arginine	13-23	growth hormone 1	Homo sapiens	51-65
18387333-1	2008	Human ADAM15 is unique among the A disintegrin and metalloprotease domain (ADAM) family because of the integrin binding motif Arg-Gly-Asp (RGD) within its disintegrin domain.	Arginine	126-130	ADAM metallopeptidase domain 15	Homo sapiens	6-12
18638502-6	2008	TSR domains of the three trout properdin isoforms seem to adopt the folding pattern of human thrombospondin 1 TSP-1 domains, where each TSP-1 domain forms an antiparallel three-stranded structure that consists of alternative stacked layers of Trp and Arg residues from respective strands capped by disulfide bonds on each end.	Arginine	251-254	thrombospondin 1	Homo sapiens	93-109
18638502-6	2008	TSR domains of the three trout properdin isoforms seem to adopt the folding pattern of human thrombospondin 1 TSP-1 domains, where each TSP-1 domain forms an antiparallel three-stranded structure that consists of alternative stacked layers of Trp and Arg residues from respective strands capped by disulfide bonds on each end.	Arginine	251-254	thrombospondin 1	Homo sapiens	110-115
18708700-3	2008	Preliminary data showed that concentrations of ADMA, symmetrical dimethylarginine (SDMA), citrulline and arginine in human urine were increased after administration of a single intravenous erythropoietin injection (2000 U day(-1), Epocrine, St-Petersburg, Russia).	Arginine	73-81	erythropoietin	Homo sapiens	189-203
18714570-11	2008	The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.	Arginine	21-24	tumor protein p53	Homo sapiens	17-20
18714570-11	2008	The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.	Arginine	25-28	tumor protein p53	Homo sapiens	17-20
18714570-11	2008	The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.	Arginine	25-28	tumor protein p53	Homo sapiens	17-20
19065769-3	2008	TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer.	Arginine	49-57	tumor protein p53	Homo sapiens	0-4
18991678-3	2008	NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA), a naturally occurring amino acid found in plasma and various types of tissues.	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	52-63
18991678-3	2008	NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA), a naturally occurring amino acid found in plasma and various types of tissues.	Arginine	114-124	nitric oxide synthase 2	Homo sapiens	52-63
17928367-1	2008	OBJECTIVE: We sought to determine whether dysregulation of arginine metabolism is related to insulin resistance and underlies impaired nitric oxide (NO) generation in type 2 diabetic patients.	Arginine	59-67	insulin	Homo sapiens	93-100
18156399-12	2008	We conclude that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70(S6k)-independent mechanism.	Arginine	48-51	mechanistic target of rapamycin kinase	Homo sapiens	199-228
18803266-0	2008	p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases.	Arginine	21-29	tumor protein p53	Homo sapiens	0-3
18803266-7	2008	In conclusion, HT patients feature a greater ratio of arginine homozygosity at p53 codon 72 than in the case for normal subjects.	Arginine	54-62	tumor protein p53	Homo sapiens	79-82
18803266-8	2008	The p53 codon 72 proline/arginine polymorphism may be a genetic marker to predict the increased susceptibility of development of HT.	Arginine	25-33	tumor protein p53	Homo sapiens	4-7
17959710-5	2008	The fact that the Ile6.40(420)Arg/Lys/Glu mutant receptors are highly active CAM H(1)Rs leads us to suggest that a positively charged residue, presumably the highly conserved Arg3.50 from the DRY motif, interacts in a direct or an indirect (through other side chains or/and internal water molecules) manner with the acidic Asp2.50..Asn7.49 pair for receptor activation.	Arginine	30-33	beta-secretase 1	Homo sapiens	323-327
18773861-6	2008	However, in gene-gene interaction, EGFR 497Arg/Arg*EGF +61A/A showed significant risk for EC (OR 2.47, p = 0.011).	Arginine	43-46	epidermal growth factor receptor	Homo sapiens	35-39
19088492-7	2008	In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f.	Arginine	26-29	proopiomelanocortin	Homo sapiens	73-77
19088492-7	2008	In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f.	Arginine	30-33	proopiomelanocortin	Homo sapiens	73-77
18547979-8	2008	Deletion of an arginine at the N terminus of P17 abolished its ability to inhibit RGS4 GAP activity, as did deletions of C-terminal residues.	Arginine	15-23	family with sequence similarity 72 member B	Homo sapiens	45-48
18197538-2	2008	Polymorphisms in the signal sequence genetically may be responsible for increased TGF-beta1 production (i.e., a substitution at amino acid position 10 and 25, +869 Leu(10)-Pro and +915 Arg(25)-Pro, respectively).	Arginine	185-188	transforming growth factor beta 1	Homo sapiens	82-91
18085519-0	2008	The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer"s Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Arginine	74-77	angiotensin I converting enzyme	Homo sapiens	16-45
18085519-0	2008	The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer"s Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.	Arginine	74-77	amyloid beta precursor protein	Homo sapiens	106-111
18323821-0	2008	Purification of human plasma fibronectin using immobilized gelatin and Arg affinity chromatography.	Arginine	71-74	fibronectin 1	Homo sapiens	29-40
18612219-0	2008	Role of p53 codon 72 arginine allele in cell survival in vitro and in the clinical outcome of patients with advanced breast cancer.	Arginine	21-29	tumor protein p53	Homo sapiens	8-11
18085519-6	2008	The use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) coupled with the (18)O-labeled internal standard approach has allowed us to show that (i) the N-domain of ACE (N-ACE), but not the C-domain, selectively cleaves the Arg-5-His-6 bond in both peptides, and that (ii) N-ACE hydrolyzes the isoAsp-7 analogue more efficiently than the non-modified one.	Arginine	267-270	angiotensin I converting enzyme	Homo sapiens	208-211
18612219-1	2008	BACKGROUND: The p53 codon 72 polymorphism, which results in either an arginine or proline residue, plays a different role in vitro and in vivo in cell survival and drug resistance.	Arginine	70-78	tumor protein p53	Homo sapiens	16-19
17827260-1	2007	Emerging evidence supports the idea that arginase, expressed in the vascular endothelial cells of humans and other species, modulates endothelial nitric oxide (NO) synthase-3 (NOS-3) activity by regulating intracellular L-arginine bioavailability.	Arginine	220-230	nitric oxide synthase 3	Homo sapiens	146-181
17942396-4	2007	The sequence of IkappaB-alpha required for Tat inhibition spans from amino acids 72 to 287 and includes the nuclear localization signal, the carboxyl-terminal nuclear export signal, and the binding site for the arginine-rich domain of Tat.	Arginine	211-219	NFKB inhibitor alpha	Homo sapiens	16-29
18079182-2	2007	As arginine methylation of histones is an important mechanism in transcriptional regulation, we asked whether PRMT6 possesses activity toward histones.	Arginine	3-11	protein arginine methyltransferase 6	Homo sapiens	110-115
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	96-100
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	255-259
18056632-1	2007	Autosomal dominant familial isolated hypoparathyroidism (AD-FIH) is caused by a Cys --&gt; Arg mutation (C18R) in the hydrophobic core of the signal peptide of human preproparathyroid hormone (PPTH).	Arginine	91-94	parathyroid hormone	Homo sapiens	166-191
17823309-4	2007	Here, we identified a polyproline-arginine sequence in the human pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85/CMS family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS, CIN85, and CD2BP3) members.	Arginine	34-42	SH3 domain containing kinase binding protein 1	Homo sapiens	139-144
17823309-4	2007	Here, we identified a polyproline-arginine sequence in the human pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85/CMS family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS, CIN85, and CD2BP3) members.	Arginine	34-42	SH3 domain containing kinase binding protein 1	Homo sapiens	244-249
17823309-4	2007	Here, we identified a polyproline-arginine sequence in the human pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85/CMS family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS, CIN85, and CD2BP3) members.	Arginine	34-42	SH3 domain containing kinase binding protein 1	Homo sapiens	255-261
17638012-3	2007	We found that the neutralisation of the uppermost arginines in the IS4, IIS4 and IIIS4 segments shifted the voltage dependence of channel activation in a hyperpolarising direction, with the most prominent effect in the IS4 mutant.	Arginine	50-59	IS4	Homo sapiens	67-70
17967451-9	2007	However, the methylation of arginine residues in the RGG domain is necessary for CIRP to exit the nucleus to be further recruited into SGs.	Arginine	28-36	cold inducible RNA binding protein	Homo sapiens	81-85
17878257-5	2007	DESIGN: SI, acute insulin response to iv glucose (AIRg), maximally potentiated insulin response to arginine (AIRmax), and disposition indexes (DIs) (DI = SI * AIRg; DImax = SI * AIRmax) were compared among nondiabetic Caucasian and African-American individuals with and without a family history of diabetes.	Arginine	99-107	insulin	Homo sapiens	18-25
17878257-5	2007	DESIGN: SI, acute insulin response to iv glucose (AIRg), maximally potentiated insulin response to arginine (AIRmax), and disposition indexes (DIs) (DI = SI * AIRg; DImax = SI * AIRmax) were compared among nondiabetic Caucasian and African-American individuals with and without a family history of diabetes.	Arginine	99-107	insulin	Homo sapiens	79-86
18085569-2	2007	We show that bradykinin and three modified peptides containing the basic residue arginine or lysine form stable interactions with single-stranded oligonucleotides.	Arginine	81-89	kininogen 1	Homo sapiens	13-23
18341090-5	2007	RESULTS: Maximum GH stimulation for Arg and ITT was 6.3 (1.0-7.8) and 6.7 (0.5-7.7) ng/ml, respectively.	Arginine	36-39	growth hormone 1	Homo sapiens	17-19
18341090-6	2007	Peak GH for the Arg + GHRH test was 36.3 (4.3-84.5) ng/ml and significantly different from the other provocative tests.	Arginine	16-19	growth hormone 1	Homo sapiens	5-7
18086002-2	2007	It is synthesized from the oxidation of L-arginine by the enzyme, endothelial nitric oxide synthase (eNOS).	Arginine	40-50	nitric oxide synthase 3	Homo sapiens	66-99
18086002-2	2007	It is synthesized from the oxidation of L-arginine by the enzyme, endothelial nitric oxide synthase (eNOS).	Arginine	40-50	nitric oxide synthase 3	Homo sapiens	101-105
17985933-9	2007	Residues Lys 7 and Arg 5 play important roles in the interaction with MEK5 PB1.	Arginine	19-22	mitogen-activated protein kinase kinase 5	Homo sapiens	70-74
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	23-26	coagulation factor II, thrombin	Homo sapiens	61-69
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	33-36	coagulation factor II, thrombin	Homo sapiens	61-69
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	33-36	coagulation factor II, thrombin	Homo sapiens	61-69
17878169-6	2007	Our results indicate that thrombin exosite II is not involved in cleavage at Arg(709) and that both thrombin exosites are important for recognition and cleavage at Arg(1545).	Arginine	164-167	coagulation factor II, thrombin	Homo sapiens	100-108
17878169-8	2007	This indicates that proteolysis of FV by thrombin at Arg(709), Arg(1018), and Arg(1545) show different cleavage requirements with respect to interactions mediated by thrombin exosites and areas that surround the respective cleavage sites.	Arginine	53-56	coagulation factor II, thrombin	Homo sapiens	41-49
17878605-3	2007	Genetic analysis revealed the patient to be heterozygous for a nonsense mutation in codon 276 of the HNF1beta gene (CGA or Arginine to TGA or stop codon; R276X).	Arginine	123-131	HNF1 homeobox B	Homo sapiens	101-109
18057376-1	2007	OBJECTIVE: To define the appropriate diagnostic cut-off limits for the GH response to GHRH+arginine (ARG) test and IGF-I levels, using receiver operating characteristics (ROC) curve analysis, in late adolescents and young adults.	Arginine	101-104	growth hormone releasing hormone	Homo sapiens	86-90
17638012-3	2007	We found that the neutralisation of the uppermost arginines in the IS4, IIS4 and IIIS4 segments shifted the voltage dependence of channel activation in a hyperpolarising direction, with the most prominent effect in the IS4 mutant.	Arginine	50-59	IS4	Homo sapiens	73-76
17965237-9	2007	Conversely, Arg gain of function promotes adherens junction formation through a Crk-dependent pathway in cells with weak junctions.	Arginine	12-15	CRK proto-oncogene, adaptor protein	Homo sapiens	80-83
17848548-1	2007	The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin.	Arginine	96-99	coagulation factor II, thrombin	Homo sapiens	29-37
17848548-1	2007	The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin.	Arginine	156-159	coagulation factor II, thrombin	Homo sapiens	29-37
17848563-2	2007	The folding defect in DeltaF508 cystic fibrosis transmembrane conductance regulator might be correctable because misfolding of a P-glycoprotein (P-gp; ABCB1) mutant lacking the equivalent residue (DeltaY490) could be corrected with drug substrates or by introduction of an arginine residue into transmembrane (TM) segments 5 (I306R) or 6 (F343R).	Arginine	273-281	CF transmembrane conductance regulator	Homo sapiens	32-83
17848563-2	2007	The folding defect in DeltaF508 cystic fibrosis transmembrane conductance regulator might be correctable because misfolding of a P-glycoprotein (P-gp; ABCB1) mutant lacking the equivalent residue (DeltaY490) could be corrected with drug substrates or by introduction of an arginine residue into transmembrane (TM) segments 5 (I306R) or 6 (F343R).	Arginine	273-281	ATP binding cassette subfamily B member 1	Homo sapiens	129-143
17848563-2	2007	The folding defect in DeltaF508 cystic fibrosis transmembrane conductance regulator might be correctable because misfolding of a P-glycoprotein (P-gp; ABCB1) mutant lacking the equivalent residue (DeltaY490) could be corrected with drug substrates or by introduction of an arginine residue into transmembrane (TM) segments 5 (I306R) or 6 (F343R).	Arginine	273-281	ATP binding cassette subfamily B member 1	Homo sapiens	151-156
17848563-3	2007	Possible mechanisms of arginine rescue were that they mimicked some of the effects of drug substrate interactions with P-gp or that they affected global folding such that all drug substrate/modulator interactions with P-gp were altered.	Arginine	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	119-123
17848563-3	2007	Possible mechanisms of arginine rescue were that they mimicked some of the effects of drug substrate interactions with P-gp or that they affected global folding such that all drug substrate/modulator interactions with P-gp were altered.	Arginine	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	218-222
17848563-6	2007	We then tested whether arginine suppressor mutations had local or global effects on P-gp interactions with drug substrates and modulators.	Arginine	23-31	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
17848563-9	2007	These results show that the arginine mutations affect a subset of drug-binding sites and suggest that they rescue processing mutants by mimicking drug substrate interactions with P-gp.	Arginine	28-36	ATP binding cassette subfamily B member 1	Homo sapiens	179-183
17878169-8	2007	This indicates that proteolysis of FV by thrombin at Arg(709), Arg(1018), and Arg(1545) show different cleavage requirements with respect to interactions mediated by thrombin exosites and areas that surround the respective cleavage sites.	Arginine	63-66	coagulation factor II, thrombin	Homo sapiens	41-49
17878169-8	2007	This indicates that proteolysis of FV by thrombin at Arg(709), Arg(1018), and Arg(1545) show different cleavage requirements with respect to interactions mediated by thrombin exosites and areas that surround the respective cleavage sites.	Arginine	63-66	coagulation factor II, thrombin	Homo sapiens	41-49
17878166-9	2007	The Arg(26) in SCA3, replacing the Gly(26) in SCA1, is predicted to cause structural changes that result in a significantly reduced volume for the internal hydrophobic cavity in SCA3.	Arginine	4-7	caspase 3	Homo sapiens	46-50
18006764-6	2007	RESULTS: The p53 codon 72 Arg/Arg genotype was associated with increased PSA recurrence risk compared with the Arg/Pro and Pro/Pro genotypes, although the difference did not reach significance (30.3% versus 20.4%, P = 0.247).	Arginine	26-29	tumor protein p53	Homo sapiens	13-16
18006764-6	2007	RESULTS: The p53 codon 72 Arg/Arg genotype was associated with increased PSA recurrence risk compared with the Arg/Pro and Pro/Pro genotypes, although the difference did not reach significance (30.3% versus 20.4%, P = 0.247).	Arginine	30-33	tumor protein p53	Homo sapiens	13-16
18006764-6	2007	RESULTS: The p53 codon 72 Arg/Arg genotype was associated with increased PSA recurrence risk compared with the Arg/Pro and Pro/Pro genotypes, although the difference did not reach significance (30.3% versus 20.4%, P = 0.247).	Arginine	30-33	tumor protein p53	Homo sapiens	13-16
17726029-1	2007	Previous work showed that prothrombin derivatives cleavable only at Arg-320 (rMZ) or Arg-271 (rP2) are partial, rather than competitive, inhibitors of prothrombin activation by prothrombinase.	Arginine	68-71	coagulation factor II, thrombin	Homo sapiens	26-37
17726029-1	2007	Previous work showed that prothrombin derivatives cleavable only at Arg-320 (rMZ) or Arg-271 (rP2) are partial, rather than competitive, inhibitors of prothrombin activation by prothrombinase.	Arginine	85-88	coagulation factor II, thrombin	Homo sapiens	26-37
17804409-3	2007	Here we show iNOS activity is acutely up-regulated by activation of the B1-kinin receptor (B1R) in human endothelial cells or transfected HEK293 cells to generate 2.5-5-fold higher NO than that stimulated by Arg alone.	Arginine	208-211	nitric oxide synthase 2	Homo sapiens	13-17
17804409-3	2007	Here we show iNOS activity is acutely up-regulated by activation of the B1-kinin receptor (B1R) in human endothelial cells or transfected HEK293 cells to generate 2.5-5-fold higher NO than that stimulated by Arg alone.	Arginine	208-211	bradykinin receptor B1	Homo sapiens	72-94
17673517-6	2007	Furthermore, we showed that the overexpression of splicing factors alternative splicing factor/splicing factor 2, Transformer (Tra)-2alpha, and Tra2beta changes the splicing pattern of SR-B dramatically, whereas other splicing factors, such as heterogeneous nuclear ribonucleoprotein-G, SC-35, and arginine/serine-rich p40, had no effect.	Arginine	298-306	transformer 2 beta	Rattus norvegicus	144-152
17925607-9	2007	In CSX group, the patients with abnormal myocardial tissue perfusion had increased plasma ADMA levels compared with those with normal tissue perfusion (0.99+/-0.37 vs. 0.69+/-0.34 micromol/l, P=0.02), whereas plasma L-arginine levels were similar in both groups.	Arginine	216-226	NK2 homeobox 5	Homo sapiens	3-6
17653713-3	2007	On the other hand, a common polymorphism of the tumour suppressor P53 gene results in either arginine (A) or proline (P) at amino-acid position 72.	Arginine	93-101	tumor protein p53	Homo sapiens	66-69
17900136-5	2007	Using dynamic light scattering (DLS) technique, we have demonstrated the concentration-dependent suppression of light scattering intensity of both ADH and insulin aggregates upon addition of arginine to the incubation medium, a significant effect being revealed in the physiological concentration range of arginine (1-10 mM).	Arginine	191-199	insulin	Homo sapiens	155-162
17900136-5	2007	Using dynamic light scattering (DLS) technique, we have demonstrated the concentration-dependent suppression of light scattering intensity of both ADH and insulin aggregates upon addition of arginine to the incubation medium, a significant effect being revealed in the physiological concentration range of arginine (1-10 mM).	Arginine	306-314	insulin	Homo sapiens	155-162
17965961-1	2007	OBJECTIVE: To describe the clinical features of Creutzfeldt-Jakob disease with a substitution of arginine for methionine (M232R substitution) at codon 232 (CJD232) of the prion protein gene (PRNP).	Arginine	97-105	prion protein	Homo sapiens	191-195
18058599-9	2007	However, either three months or five years after SPK abnormal glucose tolerance was mainly due to a reduced glucose- and arginine-induced secretory response of insulin.	Arginine	121-129	insulin	Homo sapiens	160-167
17851678-4	2007	A region (residues 721-970) harboring an arginine triplet is essential for the cytoplasmic trafficking of ErbB2.	Arginine	41-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-111
17912468-3	2007	In vitro studies have suggested that HPV-E6 interacts more efficiently with the arginine (Arg) p53 variant at position 72 as it appears to be more susceptible to degradation through the ubiquitin proteasome pathway.	Arginine	80-88	tumor protein p53	Homo sapiens	95-98
17912468-3	2007	In vitro studies have suggested that HPV-E6 interacts more efficiently with the arginine (Arg) p53 variant at position 72 as it appears to be more susceptible to degradation through the ubiquitin proteasome pathway.	Arginine	90-93	tumor protein p53	Homo sapiens	95-98
18050141-6	2007	The kidney not only reabsorbs but also synthesizes l-arginine and appears to be a central organ for the catabolism of ADMA, mainly because it is richly endowed with the enzyme that degrades ADMA, dimethylarginine dimethylaminohydrolase (DDAH).	Arginine	51-61	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	196-235
18001199-8	2007	GH response to GHRH + ARG (arginine) positively correlated with Functional Independence Measure (FIM D; r = 0.267, p &lt; 0.02) and Level of Cognitive Functioning Scale (LCFS D; r = 0.287, p &lt; 0.01) at discharge, and negatively with Disability Rating Score at discharge (DRS D; r = -0.324, p &lt; 0.005).	Arginine	27-35	growth hormone releasing hormone	Homo sapiens	15-19
17904379-4	2007	Fragmentation patterns of luteinizing hormone releasing hormone (LHRH) and vasopressin (VP), containing one Arg and one His, respectively, were compared to those of Q(8)-LHRH and oxytocin (OT) in which the BAAR is replaced with a non-BAAR.	Arginine	108-111	arginine vasopressin	Homo sapiens	75-86
17869551-1	2007	Nitric oxide (NO) is an important vasorelaxant produced along with L-citrulline from L-arginine in a reaction catalyzed by endothelial nitric oxide synthase (eNOS).	Arginine	85-95	nitric oxide synthase 3	Homo sapiens	123-156
17822962-1	2007	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function.	Arginine	69-79	nitric oxide synthase 3	Bos taurus	0-33
17914568-2	2007	In the human RAD18 gene, one coding single nucleotide polymorphism (SNP) at codon 302, encoding either arginine (Arg, CGA) or glutamine (Gln, CAA), was reported.	Arginine	103-111	chromogranin A	Homo sapiens	118-121
18000604-4	2007	To test the hypothesis that alpha-thrombin cleaves the FVa heavy chain at Arg(643) and to evaluate the functional importance of this cleavage for FVa inactivation, site-directed mutagenesis was used to create recombinant FV molecules with mutations R(643) --&gt; Q (FV(R643Q)) and R(643) --&gt; A (FV(R643A)).	Arginine	74-77	coagulation factor II, thrombin	Homo sapiens	34-42
18000604-8	2007	Our data demonstrate that cleavage of FVa at Arg(643) by alpha-thrombin results in a partially inactive cofactor molecule and provides for an activated protein C (APC)-independent anticoagulant effect of alpha-thrombin.	Arginine	45-48	coagulation factor II, thrombin	Homo sapiens	63-71
18000604-8	2007	Our data demonstrate that cleavage of FVa at Arg(643) by alpha-thrombin results in a partially inactive cofactor molecule and provides for an activated protein C (APC)-independent anticoagulant effect of alpha-thrombin.	Arginine	45-48	coagulation factor II, thrombin	Homo sapiens	210-218
17822962-1	2007	Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important modulator of vascular function.	Arginine	69-79	nitric oxide synthase 3	Bos taurus	35-39
17850814-0	2007	ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12.	Arginine	29-37	arginine repressor	Escherichia coli	0-4
17868694-6	2007	The active site of hQPRTase is located at an alpha/beta open sandwich structure that serves as a cup for the alpha/beta barrel of the adjacent subunit with a QA binding site consisting of three arginine residues (R102, R138 and R161) and two lysine residues (K139 and K171).	Arginine	194-202	quinolinate phosphoribosyltransferase	Homo sapiens	19-27
17869444-9	2007	Furthermore, the specific Kv channel blocker for Kv1.1 (dendrotoxin-K) or Kv1.2 (tityustoxin-Kalpha) abolished the effect of l-arginine on mIPSCs in all neurons tested.	Arginine	125-135	potassium voltage-gated channel subfamily A member 2	Homo sapiens	74-79
17850814-6	2007	The hisJQMP operon is the first member of the E. coli ArgR regulon, directly repressed by liganded ArgR, where none of the core promoter elements overlaps the ARG boxes.	Arginine	159-162	arginine repressor	Escherichia coli	54-58
17954263-1	2007	A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline.	Arginine	110-118	tumor protein p53	Homo sapiens	37-41
17954263-1	2007	A common polymorphism at codon 72 of TP53, the gene encoding the tumor suppressor protein p53, encodes either arginine or proline.	Arginine	110-118	tumor protein p53	Homo sapiens	90-93
17936706-4	2007	PP1 is targeted to SRp38 through direct interaction via its arginine/serine-rich (RS) domain.	Arginine	60-68	inorganic pyrophosphatase 1	Homo sapiens	0-3
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	7-10
17941991-9	2007	Although, the secretion of insulin is not significantly increased in response to high glucose, treatment of these engineered liver cells with L-arginine stimulates insulin secretion up to three-fold.	Arginine	142-152	insulin	Homo sapiens	27-34
17941991-9	2007	Although, the secretion of insulin is not significantly increased in response to high glucose, treatment of these engineered liver cells with L-arginine stimulates insulin secretion up to three-fold.	Arginine	142-152	insulin	Homo sapiens	164-171
17941991-10	2007	This L-arginine-mediated insulin release is dependent on the production of nitric oxide.	Arginine	5-15	insulin	Homo sapiens	25-32
17941991-11	2007	CONCLUSION: Liver cells can be engineered to produce insulin and insulin secretion can be induced by treatment with L-arginine via the production of nitric oxide.	Arginine	116-126	insulin	Homo sapiens	53-60
17941991-11	2007	CONCLUSION: Liver cells can be engineered to produce insulin and insulin secretion can be induced by treatment with L-arginine via the production of nitric oxide.	Arginine	116-126	insulin	Homo sapiens	65-72
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	7-10
17644622-0	2007	Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes.	Arginine	84-92	insulin	Homo sapiens	28-35
17895567-6	2007	Sequence analysis of the AGL gene encoding GDE showed a novel nonsense mutation: a C-to-T transition at codon 285 in exon 8, resulting in substitution of the arginine codon by the stop codon (R285X).	Arginine	158-166	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	25-28
17895567-6	2007	Sequence analysis of the AGL gene encoding GDE showed a novel nonsense mutation: a C-to-T transition at codon 285 in exon 8, resulting in substitution of the arginine codon by the stop codon (R285X).	Arginine	158-166	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	43-46
17969688-3	2007	To address this issue, volatile DBP formation resulting from the chlorination of four model compounds (creatinine, urea, L-histidine, and L-arginine) was investigated over a range of chlorine/precursor (Cl/P) molar ratios.	Arginine	138-148	D-box binding PAR bZIP transcription factor	Homo sapiens	32-35
17684049-7	2007	RESULTS: The acute insulin response to arginine was significantly reduced during tyramine compared with that seen in the absence of tyramine (P = 0.036).	Arginine	39-47	insulin	Homo sapiens	19-26
17640716-2	2007	Macrophages use arginine either to synthesize nitric oxide (NO) through the inducible NO synthase (iNOS) or to produce ornithine through arginase activity.	Arginine	16-24	nitric oxide synthase 2	Homo sapiens	76-97
17640716-2	2007	Macrophages use arginine either to synthesize nitric oxide (NO) through the inducible NO synthase (iNOS) or to produce ornithine through arginase activity.	Arginine	16-24	nitric oxide synthase 2	Homo sapiens	99-103
17960133-0	2007	A substitution of arginine to lysine at the COOH-terminus of MIP caused a different binocular phenotype in a congenital cataract family.	Arginine	18-26	major intrinsic protein of lens fiber	Homo sapiens	61-64
17993769-3	2007	GH secretion, evaluated by GHRH+arginine (ARG) test, has recently been reported to be impaired in most untreated ALS patients.	Arginine	42-45	growth hormone releasing hormone	Homo sapiens	27-31
17611093-14	2007	], we found that the first two arginine residues in HBP/III5 were involved in the fibronectin-binding property of FNIII4-5, while the last two arginine residues in HBP/III5 were required for inhibition of matrix assembly and the binding of 125I-fibronectin to cell layers.	Arginine	31-39	fibronectin 1	Homo sapiens	82-93
17956695-7	2007	L-arginine and cilostazol inhibited aggregation induced by thrombin, ADP and propyl gallate, and the inhibitions were related directly with dosage.	Arginine	0-10	coagulation factor II, thrombin	Homo sapiens	59-67
17698846-4	2007	In the presence of both L-arginine and tetrahydrobiopterin, eNOS is highly coupled (&gt;90%), and the measured stoichiometry of O(2)/NADPH is very close to the theoretical value.	Arginine	24-34	nitric oxide synthase 3	Homo sapiens	60-64
17698846-5	2007	We report for the first time that the presence of L-arginine stimulates oxygen uptake by eNOS.	Arginine	50-60	nitric oxide synthase 3	Homo sapiens	89-93
17587566-12	2007	Thus, it appears that the ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation.	Arginine	171-179	androgen receptor	Homo sapiens	43-45
17587566-12	2007	Thus, it appears that the ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation.	Arginine	171-179	androgen receptor	Homo sapiens	141-143
17652459-7	2007	The kinase domain-containing Arg N-terminal half can act through the RhoA inhibitor p190RhoGAP to attenuate stress fiber formation and cell contractility.	Arginine	29-32	ras homolog family member A	Homo sapiens	69-73
17960133-10	2007	It suggests that arginine in this domain plays a crucial role in the function of the carboxyl-end of this protein and provides a helpful clue to further studies on completely understanding the physiological significance of MIP and its role in the formation of cataract.	Arginine	17-25	major intrinsic protein of lens fiber	Homo sapiens	223-226
17495006-4	2007	We started from previous observations showing that modifying [deamino(1),Arg(8)]VP in positions 4 and 8 altered the rat VP/oxytocin receptor selectivity.	Arginine	73-76	arginine vasopressin	Rattus norvegicus	80-82
17513466-3	2007	Arginase I competes with inducible nitric oxide synthase (iNOS) in macrophages for the common substrate, L-arginine, and thereby reduces nitric oxide (NO) production and increases the synthesis of host orinithine and urea.	Arginine	105-115	nitric oxide synthase 2	Homo sapiens	25-56
17513466-3	2007	Arginase I competes with inducible nitric oxide synthase (iNOS) in macrophages for the common substrate, L-arginine, and thereby reduces nitric oxide (NO) production and increases the synthesis of host orinithine and urea.	Arginine	105-115	nitric oxide synthase 2	Homo sapiens	58-62
17560540-0	2007	Prediction of HIV-1 entry inhibitors neomycin-arginine conjugates interaction with the CD4-gp120 binding site by molecular modeling and multistep docking procedure.	Arginine	46-54	CD4 molecule	Homo sapiens	87-90
17636263-3	2007	Removal of this bond in thrombin produces an approximately 100-fold loss of activity toward several chromogenic and natural substrates carrying Arg or Lys at P1.	Arginine	144-147	coagulation factor II, thrombin	Homo sapiens	24-32
17893667-10	2007	Sequencing the coding regions of MIP revealed a C&gt;T transition at nucleotide 97 in exon 1 that caused a substitution of arginine (R) to cysteine (C) at codon 33 (p.R33C).	Arginine	123-131	major intrinsic protein of lens fiber	Homo sapiens	33-36
17551000-11	2007	Insulin acutely stimulates NO(x) synthesis from arginine.	Arginine	48-56	insulin	Homo sapiens	0-7
17361366-7	2007	Also, the introduction of a short dipeptide (His-Arg) motif, a crucial component of the ag region, into different locations within the C-terminus of CFTR lead to changes in the aggregation pattern that were less striking, although still statistically significant.	Arginine	49-52	CF transmembrane conductance regulator	Homo sapiens	149-153
17537656-2	2007	The predicted prepro-NPY peptide contained a putative signal peptide of 28 amino acids and a mature NPY of 36 amino acids, followed by the proteolytic processing site Gly-Lys-Arg and 35 amino acids that comprise the C-terminal peptide of NPY.	Arginine	175-178	neuropeptide Y	Rattus norvegicus	21-24
17495006-5	2007	We synthesized a series of 13 [deamino(1),Arg(8)]VP analogs modified in positions 4 and 8.	Arginine	42-45	arginine vasopressin	Rattus norvegicus	49-51
17427197-5	2007	TGF-beta1 increases L-arginine transport (half maximal effect approximately 1.6 ng/ml) in normal D-glucose, but did not alter high D-glucose-increased L-arginine transport.	Arginine	20-30	transforming growth factor beta 1	Homo sapiens	0-9
17079356-6	2007	Among the germline p53 codon 72 heterozygotes, the Pro allele was preferentially lost (p = 0.02) while the Arg allele was mutated in the majority of cases.	Arginine	107-110	tumor protein p53	Homo sapiens	19-22
17696958-5	2007	The effects of the FFAs on the endothelial nitric oxide synthase were investigated on mRNA level by quantitative PCR, on protein level and Ser1177 phosphorylation by Western blot and on enzymatic activity on living cells using radiolabelled arginine.	Arginine	241-249	nitric oxide synthase 3	Homo sapiens	31-64
17427197-6	2007	TGF-beta1 and high D-glucose increased hCAT-1 mRNA expression ( approximately 8-fold) and maximal transport velocity (V(max)), L-[(3)H]citrulline formation from L-[(3)H]arginine (index of NO synthesis) and endothelial NO synthase (eNOS) protein abundance, but did not alter eNOS phosphorylation.	Arginine	168-177	transforming growth factor beta 1	Homo sapiens	0-9
17660250-8	2007	When the Arg mutation is added to the N-TIMP-1(AB2) mutant, it produces a gelatinase-specific inhibitor with Ki values of 2.8 and 0.4 nM for MMP-2 and -9, respectively.	Arginine	9-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	40-44
17595244-6	2007	Resistance to GHRH was assessed by GH response to GHRH plus arginine.	Arginine	60-68	growth hormone releasing hormone	Homo sapiens	14-18
17892399-8	2007	NO release and cytotoxic activity are inhibited by N-monomethyl-L-arginine (L-NMMA), a specific inhibitor of the NO pathway and increased by L-arginine, an NO precursor, and tetrahydrobiopterin (BH4), a nitric oxide synthase (NOS) cofactor.	Arginine	64-74	nitric oxide synthase 2	Homo sapiens	203-224
17566099-9	2007	CRH and l-arginine infusion evoked ACTH peaks of 23 (14-48) and 31 (21-286) ng/liter, respectively (P = 0.037 and P = 0.005 vs. saline).	Arginine	8-18	proopiomelanocortin	Homo sapiens	35-39
17566099-13	2007	CONCLUSIONS: The present outcomes indicate that the peptide ensemble comprising ghrelin, CRH, and SS (inferred by l-arginine infusion) can regulate ACTH and cortisol secretion in healthy adults.	Arginine	114-124	proopiomelanocortin	Homo sapiens	148-152
17350298-1	2007	Molecular dynamics (MD) simulations were carried out for inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms complexed with substrate (L-arginine) and the iNOS specific inhibitor GW 273629, 2 for a time period of 1.2ns.	Arginine	176-186	nitric oxide synthase 2	Homo sapiens	57-88
17350298-1	2007	Molecular dynamics (MD) simulations were carried out for inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms complexed with substrate (L-arginine) and the iNOS specific inhibitor GW 273629, 2 for a time period of 1.2ns.	Arginine	176-186	nitric oxide synthase 2	Homo sapiens	90-94
17350298-1	2007	Molecular dynamics (MD) simulations were carried out for inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) isoforms complexed with substrate (L-arginine) and the iNOS specific inhibitor GW 273629, 2 for a time period of 1.2ns.	Arginine	176-186	nitric oxide synthase 3	Homo sapiens	100-133
17658644-3	2007	By measuring inhibitory activities of fragments of the peptide, it was found that the RSFCA region was a functional site to inhibit strongly the ACE catalytic activity, and particularly both Arg and Cys residues were essential for the strong inhibitory activity.	Arginine	191-194	angiotensin I converting enzyme	Homo sapiens	145-148
17400331-9	2007	RFLP analysis of p53 codon 72 revealed 32 homozygotes for arg/arg allele (50.8%), 26 heterozygotes for arg/pro allele (41.3%), and 5 homozygotes for pro/pro allele (7.9%).	Arginine	58-61	tumor protein p53	Homo sapiens	17-20
17400331-9	2007	RFLP analysis of p53 codon 72 revealed 32 homozygotes for arg/arg allele (50.8%), 26 heterozygotes for arg/pro allele (41.3%), and 5 homozygotes for pro/pro allele (7.9%).	Arginine	62-65	tumor protein p53	Homo sapiens	17-20
17400331-9	2007	RFLP analysis of p53 codon 72 revealed 32 homozygotes for arg/arg allele (50.8%), 26 heterozygotes for arg/pro allele (41.3%), and 5 homozygotes for pro/pro allele (7.9%).	Arginine	62-65	tumor protein p53	Homo sapiens	17-20
17620342-5	2007	Ubiquitination of PGC-1alpha depended on the integrity of the C terminus-containing arginine-serine-rich domains and an RNA recognition motif.	Arginine	84-92	PPARG coactivator 1 alpha	Homo sapiens	18-28
17658644-5	2007	Taking into account the results obtained from the SPOT analysis, it was suggested that the Arg and Phe residues in RSFCA were important for a specific interaction with ACE, and the Cys residue inhibited the ACE activity.	Arginine	91-94	angiotensin I converting enzyme	Homo sapiens	168-171
17658644-5	2007	Taking into account the results obtained from the SPOT analysis, it was suggested that the Arg and Phe residues in RSFCA were important for a specific interaction with ACE, and the Cys residue inhibited the ACE activity.	Arginine	91-94	angiotensin I converting enzyme	Homo sapiens	207-210
17496212-2	2007	Cellular NO production depends absolutely on the availability of arginine, substrate of endothelial nitric oxide synthase (eNOS).	Arginine	65-73	nitric oxide synthase 3	Homo sapiens	88-121
20641803-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	149-159
17715351-3	2007	Previously, we showed that the sialic acid binding site on MAG maps to arginine 118 in Ig domain 1 (Kelm et al., 1994).	Arginine	71-79	LOC103161439	Cricetulus griseus	59-62
17442735-1	2007	L-Arginine (L-arg) is metabolized to nitric oxide (NO) by inducible NO synthase (iNOS) or to urea and L-ornithine (L-orn) by arginase.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	58-79
17442735-1	2007	L-Arginine (L-arg) is metabolized to nitric oxide (NO) by inducible NO synthase (iNOS) or to urea and L-ornithine (L-orn) by arginase.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	81-85
17442735-1	2007	L-Arginine (L-arg) is metabolized to nitric oxide (NO) by inducible NO synthase (iNOS) or to urea and L-ornithine (L-orn) by arginase.	Arginine	12-17	nitric oxide synthase 2, inducible	Mus musculus	58-79
17442735-1	2007	L-Arginine (L-arg) is metabolized to nitric oxide (NO) by inducible NO synthase (iNOS) or to urea and L-ornithine (L-orn) by arginase.	Arginine	12-17	nitric oxide synthase 2, inducible	Mus musculus	81-85
17442735-4	2007	We hypothesized that MKP-1, by attenuating iNOS expression, acts as a switch changing L-arg metabolism from NO production to L-orn production after endotoxin administration.	Arginine	86-91	nitric oxide synthase 2, inducible	Mus musculus	43-47
17496212-3	2007	In this report, evidence is provided demonstrating that treatment with TNF-alpha (10 ng/ml) suppresses not only eNOS expression but also the availability of arginine via the coordinate suppression of argininosuccinate synthase (AS) expression in aortic endothelial cells.	Arginine	157-165	tumor necrosis factor	Homo sapiens	71-80
17654043-3	2007	Twenty day treatment with 3 g of l-arginine and 75 mg of acetylsalicylic acid daily resulted in a decrease of the level of lipid peroxidation products and augmentation of alpha-1-antitrypsin activity.	Arginine	33-43	serpin family A member 1	Homo sapiens	171-190
17592510-6	2007	Adhesion assays revealed that baicalein stimulated endothelial cell adhesion to fibronectin and vitronectin, effects blocked by the synthetic peptide Arg-Gly-Asp (RGD).	Arginine	150-153	vitronectin	Rattus norvegicus	96-107
17668007-5	2007	The linker connecting RRM1 and RRM2 contains arginine residues, which provide a binding site for the mRNA export factor TAP, and when TAP binds to this region it displaces RNA bound to RRM2.	Arginine	45-53	nuclear RNA export factor 1	Mus musculus	101-123
17519310-1	2007	CONTEXT AND OBJECTIVE: A single missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C) yields a mutant GH-R77C peptide, which was described as natural GH antagonist.	Arginine	92-100	growth hormone 1	Homo sapiens	57-61
17486142-6	2007	Uncoupling of eNOS (one electron transfer to molecular oxygen, the second substrate of eNOS) during ischemia-reperfusion due to diminished availability of L-arginine and/or tetrahydrobiopterin is even discussed as one major source of superoxide formation.	Arginine	155-165	nitric oxide synthase 3	Homo sapiens	14-18
17486142-6	2007	Uncoupling of eNOS (one electron transfer to molecular oxygen, the second substrate of eNOS) during ischemia-reperfusion due to diminished availability of L-arginine and/or tetrahydrobiopterin is even discussed as one major source of superoxide formation.	Arginine	155-165	nitric oxide synthase 3	Homo sapiens	87-91
17531965-3	2007	RESULTS: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively.	Arginine	119-122	tumor protein p53	Homo sapiens	139-143
17785701-1	2007	A heterozygous missense mutation in the GH-1 gene converting codon 77 from arginine (R) to cysteine (C), which was previously reported to have some GH antagonistic effect, was identified in a Syrian family.	Arginine	75-83	growth hormone 1	Homo sapiens	40-44
17875525-9	2007	Our data show that oral administration of 1.3 g/day of L-arginine significantly improves Epo production and reverses anemia without adverse effects in elderly patients who have anemia associated with renal disease and are in the predialysis state of chronic renal failure.	Arginine	55-65	erythropoietin	Homo sapiens	89-92
17914225-4	2007	By computing the free energies of wild-type and mutant p53c binding to DNA and decomposing them into contributions from individual residues, the DNA-binding loss upon charge/noncharge -conserving mutation of Arg 273 was attributed not only to the loss of DNA phosphate contacts, but also to longer-range structural changes caused by the loss of the Asp 281 salt-bridge.	Arginine	208-211	tumor protein p53	Homo sapiens	55-58
17914225-5	2007	The results herein and in previous works suggest that Asp 281 plays a critical role in the sequence-specific DNA-binding function of p53c by (i)orienting Arg 273 and Arg 280 in an optimal position to interact with the phosphate and base groups of the consensus DNA, respectively, and (ii) helping to maintain the proper DNA-binding protein conformation.	Arginine	154-157	tumor protein p53	Homo sapiens	133-136
17914225-5	2007	The results herein and in previous works suggest that Asp 281 plays a critical role in the sequence-specific DNA-binding function of p53c by (i)orienting Arg 273 and Arg 280 in an optimal position to interact with the phosphate and base groups of the consensus DNA, respectively, and (ii) helping to maintain the proper DNA-binding protein conformation.	Arginine	166-169	tumor protein p53	Homo sapiens	133-136
17553875-4	2007	An in vitro cleavage assay revealed that cathepsin L cleaves the capsid protein between amino acid residues Lys(18) and Arg(19), which are well conserved among the mosquito-borne flaviviruses.	Arginine	120-123	cathepsin L	Homo sapiens	41-52
17560156-4	2007	In this review, we discuss a new regulatory mechanism for the metabolism of ADMA in which L-arginine acts as a competitive inhibitor of DDAH activity.	Arginine	90-100	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	136-140
17715007-3	2007	The Arg residues in TNF alpha or LCS-7 were important for their interaction with LLT-18.	Arginine	4-7	tumor necrosis factor	Homo sapiens	20-29
17526733-4	2007	Effects of intoxication on murine ADPRH-/- cells were greater than those on wild-type cells and were significantly reduced by overexpression of wild-type ADPRH in ADPRH-/- cells, as evidenced by both ADP-ribose-arginine content and Gsalpha modification.	Arginine	211-219	ADP-ribosylarginine hydrolase	Mus musculus	154-159
17526733-4	2007	Effects of intoxication on murine ADPRH-/- cells were greater than those on wild-type cells and were significantly reduced by overexpression of wild-type ADPRH in ADPRH-/- cells, as evidenced by both ADP-ribose-arginine content and Gsalpha modification.	Arginine	211-219	ADP-ribosylarginine hydrolase	Mus musculus	154-159
17513300-7	2007	Moreover, we show that Arg(285) becomes more accessible, and this residue is located in a region of beta-arrestin1 responsible for stabilization of its polar core.	Arginine	23-26	arrestin beta 1	Homo sapiens	100-114
17980096-10	2007	p53 Arg/Arg genotype may be a genetically susceptible factor to HPV-associated cervical carcinoma in Uigur.	Arginine	4-7	tumor protein p53	Homo sapiens	0-3
17980096-10	2007	p53 Arg/Arg genotype may be a genetically susceptible factor to HPV-associated cervical carcinoma in Uigur.	Arginine	8-11	tumor protein p53	Homo sapiens	0-3
17708842-11	2007	CONCLUSION: L-Arginine could protect against intestinal mucosal injury and depress the serum level of iNOS in severe abdominal infection of rats.	Arginine	12-22	nitric oxide synthase 2	Rattus norvegicus	102-106
17387224-0	2007	Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential.	Arginine	0-8	fms related receptor tyrosine kinase 3	Homo sapiens	101-105
17466295-0	2007	Role for Btg1 and Btg2 in growth arrest of WEHI-231 cells through arginine methylation following membrane immunoglobulin engagement.	Arginine	66-74	BTG anti-proliferation factor 2	Mus musculus	18-22
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Arginine	262-265	coagulation factor II	Mus musculus	155-163
17550233-5	2007	PRMT1 and PRMT3 showed a preference for methylating arginine residues in the first AT-hook of HMGA1 proteins, whereas PRMT6 methylated mainly residues in the second AT-hook.	Arginine	52-60	protein arginine methyltransferase 3	Homo sapiens	10-15
17320349-2	2007	According to the currently prevailing model, constructed for rhodopsin and structurally related receptors, the arginine of the conserved "DRY" motif located at the cytosolic end of TM3 (R3.50) would interact with acidic residues in TM3 (D/E3.49) and TM6 (D/E6.30) at the resting state and shift out of this polar pocket upon agonist stimulation.	Arginine	111-119	rhodopsin	Homo sapiens	61-70
17452329-6	2007	In addition, we prepared human beta-defensin 1 (hBD1) and (Lys--&gt;Arg)hBD1 in which all four Lys residues were substituted for Arg.	Arginine	68-71	defensin beta 1	Homo sapiens	72-76
17452329-6	2007	In addition, we prepared human beta-defensin 1 (hBD1) and (Lys--&gt;Arg)hBD1 in which all four Lys residues were substituted for Arg.	Arginine	129-132	defensin beta 1	Homo sapiens	72-76
17452329-8	2007	1) Arg-containing HNP1 and (Lys--&gt;Arg)hBD1 are functionally better than Lys-HNP1 and hBD1, respectively; the difference between Arg and Lys is more evident in the alpha-defensin than in the beta-defensin and is more evident at low salt concentrations than at high salt concentrations.	Arginine	37-40	defensin beta 1	Homo sapiens	41-45
17452329-8	2007	1) Arg-containing HNP1 and (Lys--&gt;Arg)hBD1 are functionally better than Lys-HNP1 and hBD1, respectively; the difference between Arg and Lys is more evident in the alpha-defensin than in the beta-defensin and is more evident at low salt concentrations than at high salt concentrations.	Arginine	37-40	defensin beta 1	Homo sapiens	41-45
17354225-3	2007	Here, we show that TNF-alpha also induces expression of arate-limiting enzyme in arginine synthesis, argininosuccinate synthetase (AS), thereby linking inflammation with several arginine-dependent metabolic pathways, implicated in accelerated carcinogenesis and tumour progression.	Arginine	81-89	tumor necrosis factor	Homo sapiens	19-28
17591984-5	2007	We tested the rat isoform of NaV1.4 harboring the HypoPP mutation R663H (human R669H ortholog) at the outermost arginine of S4 in domain II for a gating-pore conductance.	Arginine	112-120	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	50-56
17340133-0	2007	Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression.	Arginine	24-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
17340133-0	2007	Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression.	Arginine	24-34	nitric oxide synthase 2, inducible	Mus musculus	112-116
17340133-2	2007	The aim of this study is to examine the effect of limited availability of L: -arginine on the DNA-binding activity of NF-kappaB, a dominant transcription factor in inflammation, and the consequence for the expression pattern of inducible nitric oxide synthase (iNOS) in murine keratinocytes.	Arginine	74-86	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-127
17340133-2	2007	The aim of this study is to examine the effect of limited availability of L: -arginine on the DNA-binding activity of NF-kappaB, a dominant transcription factor in inflammation, and the consequence for the expression pattern of inducible nitric oxide synthase (iNOS) in murine keratinocytes.	Arginine	74-86	nitric oxide synthase 2, inducible	Mus musculus	228-259
17340133-2	2007	The aim of this study is to examine the effect of limited availability of L: -arginine on the DNA-binding activity of NF-kappaB, a dominant transcription factor in inflammation, and the consequence for the expression pattern of inducible nitric oxide synthase (iNOS) in murine keratinocytes.	Arginine	74-86	nitric oxide synthase 2, inducible	Mus musculus	261-265
17340133-3	2007	Low availability of L: -arginine leads to activation and increased DNA-binding activity of NF-kappaB and induction of iNOS messenger RNA (mRNA) in the absence of cytokines, but not to translation into iNOS protein.	Arginine	20-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
17340133-3	2007	Low availability of L: -arginine leads to activation and increased DNA-binding activity of NF-kappaB and induction of iNOS messenger RNA (mRNA) in the absence of cytokines, but not to translation into iNOS protein.	Arginine	20-32	nitric oxide synthase 2, inducible	Mus musculus	118-122
17340133-7	2007	These results demonstrate that the availability of L: -arginine can play a role in the control of gene expression by augmenting the DNA-binding activity of NF-kappaB, which can affect the initiation and progression of dermal inflammation.	Arginine	51-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-165
17666360-5	2007	TPN supplemented with arginine resulted in significant increase in CD4+ T cells, NK cells and CD4+/CD8+ T cell ratio in the peripheral blood, as well as in IL-2 and IFN-gamma levels.	Arginine	22-30	interleukin 2	Homo sapiens	156-160
17666360-5	2007	TPN supplemented with arginine resulted in significant increase in CD4+ T cells, NK cells and CD4+/CD8+ T cell ratio in the peripheral blood, as well as in IL-2 and IFN-gamma levels.	Arginine	22-30	interferon gamma	Homo sapiens	165-174
17666360-7	2007	CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC.	Arginine	21-29	interleukin 2	Homo sapiens	123-127
17666360-7	2007	CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC.	Arginine	21-29	interferon gamma	Homo sapiens	132-141
17666360-7	2007	CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC.	Arginine	166-174	interleukin 2	Homo sapiens	123-127
17666360-7	2007	CONCLUSION: TPN with arginine supplementation can augment the percentages of CD4+ T lymphocytes and NK cells, and increase IL-2 and IFN-gamma levels, suggesting that arginine can enhance cell-mediated immunity in postoperative patients with HCC.	Arginine	166-174	interferon gamma	Homo sapiens	132-141
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	22-26
17483743-5	2007	Among the PDF groups, IL-8 secretions from ECs and PMNs were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg, and this was consistent with the expression of the IL-8 receptor on PMNs.	Arginine	130-133	C-X-C motif chemokine ligand 8	Homo sapiens	186-190
17483743-6	2007	In addition, CAM expressions on ECs and CD11b expression on PMNs, as well as PMN transmigration, were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg.	Arginine	137-140	calmodulin 3	Homo sapiens	13-16
17483743-6	2007	In addition, CAM expressions on ECs and CD11b expression on PMNs, as well as PMN transmigration, were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg.	Arginine	171-174	calmodulin 3	Homo sapiens	13-16
17483743-11	2007	Arginine administration at levels similar to or higher than physiological concentrations reduced IL-8 and CAM expression, and PMN transmigration was also decreased after stimulation with plasma or PDF from surgical patients.	Arginine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
17483743-11	2007	Arginine administration at levels similar to or higher than physiological concentrations reduced IL-8 and CAM expression, and PMN transmigration was also decreased after stimulation with plasma or PDF from surgical patients.	Arginine	0-8	calmodulin 3	Homo sapiens	106-109
17354225-3	2007	Here, we show that TNF-alpha also induces expression of arate-limiting enzyme in arginine synthesis, argininosuccinate synthetase (AS), thereby linking inflammation with several arginine-dependent metabolic pathways, implicated in accelerated carcinogenesis and tumour progression.	Arginine	178-186	tumor necrosis factor	Homo sapiens	19-28
17354225-8	2007	In summary, high levels of AS expression, which may be required for several arginine-dependent processes in cancer, including the production of nitric oxide, proline, pyrimidines and polyamines, is regulated by TNF-alpha and may provide an important molecular pathway linking inflammation and metabolism to ovarian tumorigenesis.	Arginine	76-84	tumor necrosis factor	Homo sapiens	211-220
17525731-5	2007	Alternatively, we found that arginine 314 (Arg314) in the CREB basic-leucine zipper (bZIP) domain contributed to CBP/p300 recruitment and KIX-independent CREB transactivation function.	Arginine	29-37	CREB binding protein	Homo sapiens	113-121
17449045-4	2007	While inclusion of arginine during loading of IL-6 resulted in incomplete binding to the low-substituted phenyl-sepharose, binding was complete to the high-substituted phenyl-sepharose.	Arginine	19-27	interleukin 6	Homo sapiens	46-50
17449045-5	2007	Arginine facilitated elution of IL-6 from both columns.	Arginine	0-8	interleukin 6	Homo sapiens	32-36
17449045-6	2007	These results demonstrate that arginine weakens hydrophobic interactions between IL-6 and the phenyl-sepharose.	Arginine	31-39	interleukin 6	Homo sapiens	81-85
17477906-3	2007	A mutant p21(Cip1) in which all six lysines were changed to arginines was protected against H(2)O(2) treatment.	Arginine	60-69	cyclin dependent kinase inhibitor 1A	Homo sapiens	13-17
17320923-4	2007	Furthermore, we observed that deletion or substitution of arginine at position 59 (Arg(59)) within the CD4 peptide sequence abrogated its gp120-shedding property.	Arginine	58-66	CD4 molecule	Homo sapiens	103-106
17320923-4	2007	Furthermore, we observed that deletion or substitution of arginine at position 59 (Arg(59)) within the CD4 peptide sequence abrogated its gp120-shedding property.	Arginine	83-86	CD4 molecule	Homo sapiens	103-106
17320923-5	2007	These results indicate a critical role for Arg(59) in the CD4 for conformational changes in gp120 during the sequential process of entry and infection by HIV-1.	Arginine	43-46	CD4 molecule	Homo sapiens	58-61
17549378-4	2007	Three of the cell lines (Amc-HN-3 to 5) that expressed the p16 mRNA had the same nonsense mutation at codon 50 (CGA-Arg to TGA-Ter).	Arginine	116-119	cyclin dependent kinase inhibitor 2A	Homo sapiens	59-62
17549378-6	2007	The Amc-HN-2 cell line (p16 exon-positive/mRNA-negative) had a single base deletion at codon 38 (CGG-Arg to CG), which resulted in a frameshift and a consequent stop signal at codon 44.	Arginine	101-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	24-27
17536854-1	2007	Mammalian inducible nitric oxide synthase (iNOS) catalyzes the production of l-citrulline and nitric oxide (NO) from L-arginine and O2.	Arginine	117-127	nitric oxide synthase 2	Homo sapiens	10-41
17536854-1	2007	Mammalian inducible nitric oxide synthase (iNOS) catalyzes the production of l-citrulline and nitric oxide (NO) from L-arginine and O2.	Arginine	117-127	nitric oxide synthase 2	Homo sapiens	43-47
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	67-75	F-box and WD repeat domain containing 7	Homo sapiens	5-10
17492690-2	2007	The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect.	Arginine	35-43	tumor protein p53	Homo sapiens	4-8
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	67-75	F-box and WD repeat domain containing 7	Homo sapiens	165-170
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	86-89	F-box and WD repeat domain containing 7	Homo sapiens	5-10
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	86-89	F-box and WD repeat domain containing 7	Homo sapiens	165-170
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	96-99	F-box and WD repeat domain containing 7	Homo sapiens	5-10
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	96-99	F-box and WD repeat domain containing 7	Homo sapiens	165-170
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	96-99	F-box and WD repeat domain containing 7	Homo sapiens	5-10
17575125-4	2007	Most hCDC4 mutations found were missense substitutions at critical arginine residues (Arg(465), Arg(479), and Arg(505)) localized in the substrate-binding region of hCdc4.	Arginine	96-99	F-box and WD repeat domain containing 7	Homo sapiens	165-170
17397797-1	2007	In endothelial cells Tumor Necrosis Factor-alpha (TNFalpha) stimulates arginine transport through the increased expression of SLC7A2/CAT2 transcripts.	Arginine	71-79	tumor necrosis factor	Homo sapiens	21-48
17535973-5	2007	The overall 12-yr survival was increased in p53 Arg/Pro heterozygotes with 3% (P = 0.003) and in Pro/Pro homozygotes with 6% (P = 0.002) versus Arg/Arg homozygotes, corresponding to an increase in median survival of 3 yr for Pro/Pro versus Arg/Arg homozygotes.	Arginine	48-51	tumor protein p53	Homo sapiens	44-47
16973168-4	2007	The high-arsenic exposure group with GSTP1 variant genotypes of Ile/Val and Val/Val, and with the p53 variant genotypes of Arg/Pro and Pro/Pro had 6.0- and 3.1-fold higher risks of carotid atherosclerosis, respectively.	Arginine	123-126	tumor protein p53	Homo sapiens	98-101
17442499-1	2007	Nardilysin is a metalloendopeptidase that in vitro cleaves peptides such as dynorphin-A, somatostatin-28, alpha-neoendorphin and glucagon at the N-terminus of arginine and lysine residues in dibasic moieties.	Arginine	159-167	nardilysin convertase	Homo sapiens	0-10
17684620-0	2007	[Effect of L-arginine supplementation on secretion of human growth hormone and insulin-like growth factor in adults].	Arginine	11-21	growth hormone 1	Homo sapiens	60-74
17684620-1	2007	Based on presumptions that the infusion of amino acids can augment the release of human growth hormone (hGH) and that this metabolism is related with secretion of insulin-like growth factor I (IGF-I), the purpose of this study was to verify the effect of L-arginine supplementation on GH and IGF-I in adults.	Arginine	255-265	insulin like growth factor 1	Homo sapiens	163-191
17684620-1	2007	Based on presumptions that the infusion of amino acids can augment the release of human growth hormone (hGH) and that this metabolism is related with secretion of insulin-like growth factor I (IGF-I), the purpose of this study was to verify the effect of L-arginine supplementation on GH and IGF-I in adults.	Arginine	255-265	insulin like growth factor 1	Homo sapiens	193-198
17397797-1	2007	In endothelial cells Tumor Necrosis Factor-alpha (TNFalpha) stimulates arginine transport through the increased expression of SLC7A2/CAT2 transcripts.	Arginine	71-79	tumor necrosis factor	Homo sapiens	50-58
17397797-2	2007	Here we show that also rapamycin, an inhibitor of mTOR kinase, stimulates system y(+)-mediated arginine uptake in human endothelial cells derived from either saphenous (HSVECs) or umbilical veins (HUVECs).	Arginine	95-103	mechanistic target of rapamycin kinase	Homo sapiens	50-54
17397797-3	2007	When used together with TNFalpha, rapamycin produces an additive stimulation of arginine transport in both cell models.	Arginine	80-88	tumor necrosis factor	Homo sapiens	24-32
17401439-4	2007	The NO synthase (NOS) substrate, L-arginine, and the NO donor, 3-morpholinosydnonimine chloride (SIN-1), also inhibited [(3)H]ACh release with a potency order of SIN-1&gt;L-arginine&gt;L-citrulline.	Arginine	33-43	MAPK associated protein 1	Homo sapiens	162-167
17401439-4	2007	The NO synthase (NOS) substrate, L-arginine, and the NO donor, 3-morpholinosydnonimine chloride (SIN-1), also inhibited [(3)H]ACh release with a potency order of SIN-1&gt;L-arginine&gt;L-citrulline.	Arginine	171-181	nitric oxide synthase 2	Homo sapiens	4-15
17401439-4	2007	The NO synthase (NOS) substrate, L-arginine, and the NO donor, 3-morpholinosydnonimine chloride (SIN-1), also inhibited [(3)H]ACh release with a potency order of SIN-1&gt;L-arginine&gt;L-citrulline.	Arginine	171-181	MAPK associated protein 1	Homo sapiens	97-102
17401439-9	2007	Reduction of extracellular adenosine accumulation with adenosine deaminase or with the nucleoside transport inhibitor, S-(p-nitrobenzyl)-6-thioinosine, attenuated the effects of L-arginine and L-citrulline, while not affecting inhibition by SIN-1.	Arginine	178-188	MAPK associated protein 1	Homo sapiens	241-246
17387163-4	2007	In this study, we provided several lines of evidence suggesting that IFN-gamma-mediated parasite growth enhancement was associated with L-arginine transport via mouse cationic amino acid transporter 2B (mCAT-2B).	Arginine	136-146	interferon gamma	Mus musculus	69-78
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Arginine	181-184	epoxide hydrolase 1, microsomal	Mus musculus	174-177
17387163-5	2007	(i) mRNA expression of Slc7A2, the gene encoding for mCAT-2B, as well as L-arginine transport was increased in IFN-gamma-treated Mphis.	Arginine	73-83	interferon gamma	Mus musculus	111-120
17387163-10	2007	Together, these data suggest an involvement of a novel L-arginine usage independent of iNOS and arginase activities during IFN-gamma-mediated parasite growth enhancement.	Arginine	55-65	interferon gamma	Mus musculus	123-132
17535882-9	2007	Despite substitution of asparagine with proline in the NHX(4)D motif and arginine with cysteine in the EGTR motif, AGPAT9 retains AGPAT activity suggesting that residues asparagine and arginine in the NHX(4)D and EGTR motifs respectively are not essential for the enzymatic activity.	Arginine	185-193	glycerol-3-phosphate acyltransferase 3	Homo sapiens	115-121
17403665-1	2007	Prostaglandin-endoperoxide H synthase-2 (PGHS-2) shows peroxidase activity to promote the cyclooxygenase reaction for prostaglandin H2, but one of the highly conserved amino acid residues in peroxidases, distal Arg, stabilizing the developing negative charge on the peroxide through a hydrogen-bonding interaction, is replaced with a neutral amino acid residue, Gln.	Arginine	211-214	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-39
17403665-1	2007	Prostaglandin-endoperoxide H synthase-2 (PGHS-2) shows peroxidase activity to promote the cyclooxygenase reaction for prostaglandin H2, but one of the highly conserved amino acid residues in peroxidases, distal Arg, stabilizing the developing negative charge on the peroxide through a hydrogen-bonding interaction, is replaced with a neutral amino acid residue, Gln.	Arginine	211-214	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-47
17403665-8	2007	Introduction of the bulky amino acid residue, Arg, would interfere with the ligation of a water molecule to the heme iron, suggesting that the side chain volume, and not the amide group, at position 189 is essential for the peroxidase activity of PGHS-2.	Arginine	46-49	prostaglandin-endoperoxide synthase 2	Homo sapiens	247-253
17513437-1	2007	Nitric oxide (NO) is synthesized from arginine and O2 by NO synthase (NOS).	Arginine	38-46	nitric oxide synthase 2	Homo sapiens	57-68
17457693-5	2007	Aldh5a1-/- mice accumulate GHB and gamma-aminobutyric acid (GABA) in the central nervous system, exhibit alterations of amino acids such as glutamine (Gln), alanine (Ala) and arginine (Arg), and manifest disturbances in other systems including dopamine, neurosteroids and antioxidant status.	Arginine	175-183	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	0-7
17457693-5	2007	Aldh5a1-/- mice accumulate GHB and gamma-aminobutyric acid (GABA) in the central nervous system, exhibit alterations of amino acids such as glutamine (Gln), alanine (Ala) and arginine (Arg), and manifest disturbances in other systems including dopamine, neurosteroids and antioxidant status.	Arginine	185-188	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	0-7
17327486-1	2007	The kinins, bradykinin (BK) and Lys-des[Arg(9)]-BK, are important inflammatory mediators that act via two specific G protein-coupled kinins, B(1) and B(2) receptors (B(2)R).	Arginine	40-43	kininogen 1	Homo sapiens	48-50
17327486-6	2007	The kinin agonists BK and Lys-des[Arg(9)]-BK up-regulated the expression of their respective receptors.	Arginine	34-37	kininogen 1	Homo sapiens	42-44
17513437-6	2007	Km values for arginine of arginase I and II (approximately 10 mmol/L) are much higher than that of iNOS (approximately 5 micromol/L), whereas Vmax of arginase I and II were 10(3)-10(4) times higher than that of iNOS in activated macrophages.	Arginine	14-22	nitric oxide synthase 2	Homo sapiens	211-215
17513437-7	2007	Thus, Vmax/Km values of arginases were close to that of iNOS, and these enzymes were expected to compete for arginine in the cells.	Arginine	109-117	nitric oxide synthase 2	Homo sapiens	56-60
17513447-4	2007	In myeloid cells, arginine is mainly metabolized either by inducible nitric oxide (NO) synthases (iNOS) or by arginase 1, enzymes that are stimulated by T helper 1 or 2 cytokines, respectively.	Arginine	18-26	nitric oxide synthase 2	Homo sapiens	98-102
17403527-1	2007	A very common polymorphism of p53, that of codon 72, codes either for a proline (P72) or an arginine (R72).	Arginine	92-100	tumor protein p53	Homo sapiens	30-33
17622691-12	2007	Reduced arginine supply may lead to eNOS uncoupling and generation of superoxide, contributing to HCY-induced oxidative stress.	Arginine	8-16	nitric oxide synthase 3	Homo sapiens	36-40
17389749-4	2007	This Ser (S78) is adjacent to several positively charged residues (Arg or Lys), which we show here are involved in nuclear localization of HNF4alpha and are conserved in nearly all other NRs, along with the Ser/threonine (Thr).	Arginine	67-70	hepatocyte nuclear factor 4 alpha	Homo sapiens	139-148
17482266-4	2007	L-Arginine is the substrate for the endothelial NO synthase (eNOS) to generate NO.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	48-59
17482266-4	2007	L-Arginine is the substrate for the endothelial NO synthase (eNOS) to generate NO.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	61-65
17516928-5	2007	Sequence analysis of Edn3 identified a G &gt; A transversion that encodes an arginine to histidine substitution (R96H).	Arginine	77-85	endothelin 3	Mus musculus	21-25
17482266-8	2007	The most likely mechanism that explains the occurrence of endothelial dysfunction and the effect of L-arginine is that application of L-arginine antagonizes asymmetric dimethylarginine (ADMA), the endogenous NO synthase (NOS) inhibitor.	Arginine	100-110	nitric oxide synthase 2	Homo sapiens	208-219
17482266-8	2007	The most likely mechanism that explains the occurrence of endothelial dysfunction and the effect of L-arginine is that application of L-arginine antagonizes asymmetric dimethylarginine (ADMA), the endogenous NO synthase (NOS) inhibitor.	Arginine	134-144	nitric oxide synthase 2	Homo sapiens	208-219
17482266-9	2007	This could solve the L-arginine paradox namely that L-arginine improves NO-mediated vascular function in vivo, although its baseline plasma concentration is about 25- to 30-fold higher than the Michaelis-Menten constant Km of the isolated, purified eNOS in vitro.	Arginine	52-62	nitric oxide synthase 3	Homo sapiens	249-253
17498272-3	2007	These substitutions result in a change of amino acid residues in HLA-DRB1*1376 at position 74 (Arg --&gt; Glu) and in -DRB*1465 at positions 47 (Tyr --&gt; Phe), 57 (Asp --&gt; Ser) and 74 (Glu --&gt; Ala).	Arginine	95-98	major histocompatibility complex, class II, DR beta 1	Homo sapiens	65-73
17498272-4	2007	On the other hand, sequence analysis of exons 2 and 3 for HLA-A*2471 showed a single substitution, leading to a single amino acid change at position 151 (His --&gt; Arg).	Arginine	165-168	major histocompatibility complex, class I, A	Homo sapiens	58-68
17498274-1	2007	HLA-A*2632 shows three nucleotides difference with HLA-A*260101 and HLA-A*2624 in exon 3 at codon 95 (ATC--&gt; ATG) and codon 97 (AGG --&gt; GTG), resulting in two amino acids change from Ile to Met (I95M) and Arg to Val (R97V).	Arginine	211-214	major histocompatibility complex, class I, A	Homo sapiens	0-5
16949893-2	2007	Arg serves as a substrate for the enzyme NO synthase (NOS), which produces NO, whereas monomethylarginine (L-NMMA) and asymmetric dimethylarginine (ADMA) act as competitive inhibitors of NOS.	Arginine	0-3	nitric oxide synthase 2	Homo sapiens	41-52
17337452-3	2007	To determine the importance of homodimerization on the biological and catalytic activity of Hint1, the dimer interface of human Hint1 (hHint1) was destabilized by replacement of Val(97) of hHint1 with Asp, Glu, or Arg.	Arginine	214-217	histidine triad nucleotide binding protein 1	Homo sapiens	135-141
17049318-2	2007	It is produced from the amino acid L-arginine by the action of nitric oxide synthases (NOS) in what is called the L-arginine/NO pathway.	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	63-85
17194630-2	2007	L-Arginine is converted to NO and L-citrulline by NO synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	50-61
17049318-2	2007	It is produced from the amino acid L-arginine by the action of nitric oxide synthases (NOS) in what is called the L-arginine/NO pathway.	Arginine	114-124	nitric oxide synthase 2	Homo sapiens	63-85
17357163-2	2007	Nine alpha-MSH peptide analogues were constructed by exchanging the Trp9 residue in the alpha-MSH core with the natural or artificial amino acids Arg, Asp, Cys, Gly, Leu, Nal, d-Nal, Pro, or d-Trp.	Arginine	146-149	proopiomelanocortin	Homo sapiens	5-14
17371868-6	2007	Interestingly, Lys to Arg mutations that inhibited ubiquitination restored nuclear localization to mutant p53 but had no apparent effect on p53 conformation.	Arginine	22-25	tumor protein p53	Homo sapiens	106-109
17381965-1	2007	Several studies have described reduced plasma concentrations of arginine, the substrate for nitric oxide synthase (NOS) in infants with necrotizing enterocolitis (NEC).	Arginine	64-72	nitric oxide synthase 2	Homo sapiens	92-113
17400548-4	2007	We now report that alterations in the 0-layer Gln or Arg residues of Vam7p or Nyv1p, respectively, strongly inhibit fusion.	Arginine	53-56	Vam7p	Saccharomyces cerevisiae S288C	69-74
17400548-6	2007	Rotation of the position of the arginine in the 0-layer increases the K(m) for Vam7p but does not affect the maximal rate of fusion.	Arginine	32-40	Vam7p	Saccharomyces cerevisiae S288C	79-84
17595776-6	2007	Those who had Arg/Arg at p53 codon 72 showed a 2.68-fold (95% confidence interval = 1.19-6.01) increased risk of oral cancer compared to those with Pro/Pro.	Arginine	14-17	tumor protein p53	Homo sapiens	25-28
17595776-6	2007	Those who had Arg/Arg at p53 codon 72 showed a 2.68-fold (95% confidence interval = 1.19-6.01) increased risk of oral cancer compared to those with Pro/Pro.	Arginine	18-21	tumor protein p53	Homo sapiens	25-28
17595776-9	2007	CONCLUSION: Our findings suggest that the homozygous Arg allele of the p53 codon 72 may be associated with the development of oral cancer and be a useful marker for primary prevention and anticancer intervention.	Arginine	53-56	tumor protein p53	Homo sapiens	71-74
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Arginine	40-48	regulating synaptic membrane exocytosis 1	Mus musculus	35-39
17438380-4	2007	NO, generated by catalytic activity of endothelial NO synthase (eNOS) on l-arginine, modulates vascular function and structure.	Arginine	73-83	nitric oxide synthase 3	Homo sapiens	39-62
17438380-4	2007	NO, generated by catalytic activity of endothelial NO synthase (eNOS) on l-arginine, modulates vascular function and structure.	Arginine	73-83	nitric oxide synthase 3	Homo sapiens	64-68
17331670-7	2007	The p53 72 Arg allele showed a borderline association (p = 0.07).	Arginine	11-14	tumor protein p53	Homo sapiens	4-7
17631738-2	2007	The wild type p53 protein presents a common polymorphism at position 72 resulting in either a proline or an arginine residue at this position, leading to differences between the two variants in the induction of apoptosis.	Arginine	108-116	tumor protein p53	Homo sapiens	14-17
17631738-7	2007	All of the RA patients and controls were genotyped by the polymerase chain reaction and allele-specific oligonucleotide techniques for p53 gene polymorphism Arg/Pro at codon 72.	Arginine	157-160	tumor protein p53	Homo sapiens	135-138
17940985-1	2007	INTRODUCTION: Some studies indicate, that the Trp(64)/Arg(64) polymorphism of beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.	Arginine	54-57	insulin	Homo sapiens	142-149
17341489-8	2007	Therefore, elevation of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-Delta and perhaps mutation of CLN3 predispose cells to keep arginine levels lower than normal.	Arginine	48-56	cyclin CLN3	Saccharomyces cerevisiae S288C	150-154
17341489-8	2007	Therefore, elevation of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-Delta and perhaps mutation of CLN3 predispose cells to keep arginine levels lower than normal.	Arginine	180-188	cyclin CLN3	Saccharomyces cerevisiae S288C	150-154
17311854-8	2007	In controls, logADMA and L-arginine to ADMA ratio correlated with BMI and LDL-c (P &lt; 0.05).	Arginine	25-35	component of oligomeric golgi complex 2	Homo sapiens	74-79
17299075-6	2007	RESULTS: The proband was heterozygous for a novel C--&gt;T mutation in the PPARG gene that led to the substitution of arginine 194 in PPARgamma2 isoform, a conserved residue located in the zinc finger structure involved in DNA binding, by tryptophan (R194W).	Arginine	118-126	peroxisome proliferator activated receptor gamma	Homo sapiens	75-80
17211666-2	2007	Tadpoles exposed to S-nitro-N-acetylpenicillamine (SNAP), an NO-donor, or L: -arginine, the substrate of NO synthase (NOS), showed a reversible decrease, whereas animals exposed to the NOS inhibitor Nomega-methyl-L: -arginine (L: -NMMA) exhibited an increase in ammonium release.	Arginine	74-86	nitric oxide synthase 2	Homo sapiens	105-116
17311854-7	2007	L-arginine to ADMA ratio correlated negatively with BMI (P = 0.004), fasting blood glucose (P = 0.02), and LDL-c (P = 0.01) and positively with high-density lipoprotein cholesterol (P = 0.04).	Arginine	0-10	component of oligomeric golgi complex 2	Homo sapiens	107-112
17301132-7	2007	Coincidentally, a cluster of proline, arginine, and glycine precedes the Gag-Pol junction of MuLV.	Arginine	38-46	Gag-Pol	Human immunodeficiency virus 1	73-80
17327420-5	2007	Estradiol is found to occupy only one region of PXR"s expansive ligand-binding pocket, leaving a notable 1000 A3 of space unoccupied, and to bridge between the key polar residues Ser-247 and Arg-410 in the PXR LBD.	Arginine	191-194	nuclear receptor subfamily 1 group I member 2	Homo sapiens	48-51
17599946-1	2007	A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers.	Arginine	42-50	tumor protein p53	Homo sapiens	2-6
17599946-1	2007	A TP53 gene polymorphism, resulting in an arginine (R) to proline (P) at codon 72 (TP53 R72P), has been associated with the susceptibility to various cancers.	Arginine	42-50	tumor protein p53	Homo sapiens	83-87
17208332-1	2007	The TP53 gene has a polymorphism in exon 4 at codon 72 that presents the arginine or proline genotype.	Arginine	73-81	tumor protein p53	Homo sapiens	4-8
17520476-6	2007	In contrast, mutation of the equivalent arginine to alanine in full length Kv1.2 and Kv1.4 appeared to have little or no effect on channel conductance but rather decreased cell surface protein levels by inducing partial high ER retention.	Arginine	40-48	potassium voltage-gated channel subfamily A member 2	Homo sapiens	75-80
17711694-4	2007	iNOS activity was determined by isotope-labeled L-arginine convertion rate.	Arginine	48-58	nitric oxide synthase 2	Rattus norvegicus	0-4
17474797-3	2007	The two non-synonymous single-nucleotide polymorphisms (SNPs) TP53 codon 72 Arg/Pro G&gt;C and CDKN1A codon 31 Ser/Arg C&gt;A were genotyped in 92 normal fibroblast cell strains of different radiosensitivity.	Arginine	76-79	tumor protein p53	Homo sapiens	62-66
17474797-3	2007	The two non-synonymous single-nucleotide polymorphisms (SNPs) TP53 codon 72 Arg/Pro G&gt;C and CDKN1A codon 31 Ser/Arg C&gt;A were genotyped in 92 normal fibroblast cell strains of different radiosensitivity.	Arginine	115-118	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-101
17457351-1	2007	L-arginine is the substrate of endothelial nitric oxide synthase and the main precursor of nitric oxide in the vascular endothelium, thus its effects are mediated largely by increases in nitric oxide production.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	31-64
17457351-2	2007	L-arginine has antioxidant and antiapoptotic properties, increases smooth muscle relaxation, inhibits the expression of adhesion molecules and chemotactic peptides, decreases endothelin-1 expression, and inhibits platelet aggregation.	Arginine	0-10	endothelin 1	Homo sapiens	175-187
17406354-1	2007	The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes.	Arginine	34-42	tumor protein p53	Homo sapiens	57-60
17320064-6	2007	Nitric oxide is synthesized from l-arginine via the enzyme, NO synthase (NOS), which exists in 3 isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	33-43	nitric oxide synthase 2	Rattus norvegicus	159-163
17406354-1	2007	The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes.	Arginine	113-121	tumor protein p53	Homo sapiens	57-60
17406354-3	2007	Here, we show that the transient transfection of the proline allele in p53 null cancer cells exposed to low oxygen tension or to the hypoxia-mimetic drug Desferoxamine induces a higher amount of cell death than the arginine allele.	Arginine	215-223	tumor protein p53	Homo sapiens	71-74
17406354-6	2007	These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment.	Arginine	184-192	tumor protein p53	Homo sapiens	29-32
17406354-6	2007	These data indicate that the p53 codon 72 proline allele is less permissive for the growth of cancer cells in a hypoxic environment, and suggest that the preferential retention of the arginine allele in the tumour tissues of arginine/proline heterozygous patients may depend upon its lowered capacity to induce cell death in a hypoxic tumour environment.	Arginine	225-233	tumor protein p53	Homo sapiens	29-32
16860889-1	2007	L-Arginine is the substrate of endothelial nitric oxide synthase (eNOS) and the main precursor of nitric oxide (NO) in the vascular endothelium.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	31-64
17010492-13	2007	The reason for this effect is probably based on the polymorphism of paraoxonase (PON1) in that the (192)arginine phenotype does hardly hydrolyze the arising diethylphosphoryl obidoxime.	Arginine	104-112	paraoxonase 1	Homo sapiens	81-85
17396150-2	2007	We here report a human protein, PALF (PNK and APTX-like FHA protein), with an FHA (forkhead-associated) domain and novel zinc-finger-like CYR (cysteine-tyrosine-arginine) motifs that are involved in responses to DNA damage.	Arginine	161-169	aprataxin and PNKP like factor	Homo sapiens	32-36
17396150-2	2007	We here report a human protein, PALF (PNK and APTX-like FHA protein), with an FHA (forkhead-associated) domain and novel zinc-finger-like CYR (cysteine-tyrosine-arginine) motifs that are involved in responses to DNA damage.	Arginine	161-169	aprataxin and PNKP like factor	Homo sapiens	38-67
17404322-3	2007	Remarkably, this effect was largely restricted to CD4 T cells and correlated with reduced arginine methylation of Vav1, an essential guanine nucleotide exchange factor in T cell stimulation.	Arginine	90-98	CD4 molecule	Homo sapiens	50-53
17280760-10	2007	Pretreatment with SNP and L-Arg attenuated the levels of TNF-alpha in serum in a significant manner.	Arginine	26-31	tumor necrosis factor	Rattus norvegicus	57-66
17320110-7	2007	Surprisingly, similar arginine-rich signals identified in RASSF1C and RASSF2 interact with importin-alpha and transport the heterologous cytoplasmic proteins to the nucleus.	Arginine	22-30	Ras association domain family member 2	Homo sapiens	70-76
17320110-9	2007	These results provide evidence for the first time that arginine-rich signals are able to recognize different nuclear import receptors and transport the RASSF proteins into distinct sub-cellular compartments.	Arginine	55-63	Ras association domain family member 2	Homo sapiens	152-157
17298944-6	2007	TIF1beta homodimerization properties and interaction with the KRAB domain are preserved in the mutants with lysine to arginine substitutions as confirmed by in vivo bioluminescence resonance energy transfer (BRET).	Arginine	118-126	tripartite motif containing 28	Homo sapiens	0-8
16860889-1	2007	L-Arginine is the substrate of endothelial nitric oxide synthase (eNOS) and the main precursor of nitric oxide (NO) in the vascular endothelium.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	66-70
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	74-82	nitric oxide synthase 2	Homo sapiens	102-123
17407569-6	2007	Mutation of arginine 21 to alanine in Spc-SH3 increases 3- to 4-fold the binding affinity for p41 due to elimination at the binding-site interface of the steric clash produced by the longer arginine side chain.	Arginine	12-20	mitogen-activated protein kinase 1	Homo sapiens	94-97
17392176-6	2007	Restoration of the microcirculation by treatment with Atrasentan and L-arginine minimized hypoxia and HIF-1alpha stabilization and reduced the accelerated outgrowth of micrometastases by 50%.	Arginine	69-79	hypoxia inducible factor 1 subunit alpha	Homo sapiens	102-112
17371270-3	2007	Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models by a mechanism involving NOS2 (nitric oxide synthase 2), as elimination of NOS2 alleles suppresses this phenotype.	Arginine	8-16	nitric oxide synthase 2, inducible	Mus musculus	114-118
17371270-3	2007	Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models by a mechanism involving NOS2 (nitric oxide synthase 2), as elimination of NOS2 alleles suppresses this phenotype.	Arginine	8-16	nitric oxide synthase 2, inducible	Mus musculus	120-143
17371270-3	2007	Dietary arginine enhances the risk of APC-dependent colon carcinogenesis in mouse models by a mechanism involving NOS2 (nitric oxide synthase 2), as elimination of NOS2 alleles suppresses this phenotype.	Arginine	8-16	nitric oxide synthase 2, inducible	Mus musculus	164-168
17371270-6	2007	Either loss of NOS2 alleles or inhibition of polyamine synthesis suppresses the arginine-induced increase in adenoma grade.	Arginine	80-88	nitric oxide synthase 2, inducible	Mus musculus	15-19
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	30-38	nitric oxide synthase 2	Homo sapiens	102-123
17510493-6	2007	In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects.	Arginine	59-69	chromogranin A	Homo sapiens	122-136
17300943-3	2007	To investigate the selective mechanism, a computational model was set up to simulate the interaction between residues (Trp and Arg) of insect nAChR and neonicotinoids by quantum chemistry method.	Arginine	127-130	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	142-147
17456623-0	2007	Inhibition of thrombin in plasma by heparin or arginine.	Arginine	47-55	coagulation factor II, thrombin	Homo sapiens	14-22
17456623-11	2007	Final arginine concentrations of at least 250 mM completely inhibit turbidity increase, when arginine acts in the first 4 minutes (RT) of the thrombin/ fibrinogen interaction.	Arginine	6-14	fibrinogen beta chain	Homo sapiens	152-162
17456623-11	2007	Final arginine concentrations of at least 250 mM completely inhibit turbidity increase, when arginine acts in the first 4 minutes (RT) of the thrombin/ fibrinogen interaction.	Arginine	93-101	coagulation factor II, thrombin	Homo sapiens	142-150
17456623-11	2007	Final arginine concentrations of at least 250 mM completely inhibit turbidity increase, when arginine acts in the first 4 minutes (RT) of the thrombin/ fibrinogen interaction.	Arginine	93-101	fibrinogen beta chain	Homo sapiens	152-162
17456623-12	2007	A final arginine concentration of 477 mM added at the 12-minute or 30-minute thrombin/ fibrinogen reaction time point decreases the resulting turbidity by 50% after an additional 30 minutes at RT.	Arginine	8-16	coagulation factor II, thrombin	Homo sapiens	77-85
17456623-12	2007	A final arginine concentration of 477 mM added at the 12-minute or 30-minute thrombin/ fibrinogen reaction time point decreases the resulting turbidity by 50% after an additional 30 minutes at RT.	Arginine	8-16	fibrinogen beta chain	Homo sapiens	87-97
17456623-15	2007	This study demonstrates the efficiency of two physiologic thrombin inhibitors: heparin and arginine.	Arginine	91-99	coagulation factor II, thrombin	Homo sapiens	58-66
17379002-10	2007	The same profile was obtained for L-arginine with a significantly more pronounced decrease (P&lt;.001) in the insulin clamp group (74 to 61 micromol/L, P&lt;.001) than in the saline control group (59 to 57 micromol/L, P=.95).	Arginine	34-44	insulin	Homo sapiens	110-117
17267505-0	2007	Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region.	Arginine	0-8	protein arginine methyltransferase 6	Homo sapiens	79-84
17267505-0	2007	Arginine methylation of the human immunodeficiency virus type 1 Tat protein by PRMT6 negatively affects Tat Interactions with both cyclin T1 and the Tat transactivation region.	Arginine	0-8	cyclin T1	Homo sapiens	131-140
17267505-4	2007	We now show that Tat is a specific in vitro and in vivo substrate of PRMT6 which targets the Tat R52 and R53 residues for arginine methylation.	Arginine	122-130	protein arginine methyltransferase 6	Homo sapiens	69-74
17267505-6	2007	Furthermore, arginine methylation of Tat negatively affected Tat-TAR-cyclin T1 ternary complex formation and diminished cyclin T1-dependent Tat transcriptional activation.	Arginine	13-21	cyclin T1	Homo sapiens	69-78
17267505-6	2007	Furthermore, arginine methylation of Tat negatively affected Tat-TAR-cyclin T1 ternary complex formation and diminished cyclin T1-dependent Tat transcriptional activation.	Arginine	13-21	cyclin T1	Homo sapiens	120-129
17393227-5	2007	Superoxide dismutase and catalase activities decreased under Arg treatment, while L-NAME or DIS caused stimulation.	Arginine	61-64	catalase	Rattus norvegicus	25-33
17379002-12	2007	Short-term administration of insulin was accompanied by a decrease in both ADMA and L-arginine levels, with no change in FBF, in our population of young men with borderline hypertension.	Arginine	84-94	insulin	Homo sapiens	29-36
17375198-9	2007	MMP-8 cleaves CXCL8 at Arg(5)-Ser(6) and at Val(7)-Leu(8) in CXCL5 to activate respective chemokines.	Arginine	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	14-19
17328992-7	2007	Increased IGF-1 receptor affinity that results from Arg addition to the C terminus of the B chain was attenuated by cationic extension at the N terminus of the A chain.	Arginine	52-55	insulin like growth factor 1	Homo sapiens	10-15
17289077-6	2007	The second site contains a lysine and arginine-rich motif that is highly conserved between the two T cyclins.	Arginine	38-46	cyclin T1	Homo sapiens	101-108
17229735-2	2007	Tat-specific signal peptides contain a characteristic amino acid motif ((S/T)RRXFLK) including two highly conserved consecutive arginine residues that are thought to be involved in the recognition of the signal peptides by the Tat translocase.	Arginine	128-136	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	227-230
17229735-1	2007	The twin arginine (Tat) secretion pathway allows the translocation of folded proteins across the cytoplasmic membrane of bacteria.	Arginine	9-17	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	19-22
17229735-4	2007	Replacement of the two arginine residues in a Tat-specific precursor protein by lysine-glutamine resulted in an export-defective mutant precursor that was no longer accepted by the wild-type translocase.	Arginine	23-31	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	46-49
17229735-2	2007	Tat-specific signal peptides contain a characteristic amino acid motif ((S/T)RRXFLK) including two highly conserved consecutive arginine residues that are thought to be involved in the recognition of the signal peptides by the Tat translocase.	Arginine	128-136	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	0-3
17229735-6	2007	The mutant Tat translocases still efficiently accepted the unaltered precursor protein, indicating that the substrate specificity of the translocases was not strictly changed; rather, the translocases showed an increased tolerance toward variations of the amino acids occupying the positions of the twin arginine residues in the consensus motif of a Tat signal peptide.	Arginine	304-312	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	11-14
17229735-6	2007	The mutant Tat translocases still efficiently accepted the unaltered precursor protein, indicating that the substrate specificity of the translocases was not strictly changed; rather, the translocases showed an increased tolerance toward variations of the amino acids occupying the positions of the twin arginine residues in the consensus motif of a Tat signal peptide.	Arginine	304-312	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	350-353
17227771-5	2007	Employing site-directed mutagenesis studies, we identified lysine residues 4432 and 4435 and arginine 4442 as key amino acids important for ectodomain shedding of LRP1B.	Arginine	93-101	LDL receptor related protein 1B	Homo sapiens	163-168
17297916-9	2007	We, therefore, generated an artificial p53, containing arginine residues N-terminal to the phospho-acceptor site, creating a better DAPK-1 peptide consensus and demonstrated that the Km for p531-66[ET--&gt;RR] and ATP is elevated.	Arginine	55-63	tumor protein p53	Homo sapiens	39-42
17297916-9	2007	We, therefore, generated an artificial p53, containing arginine residues N-terminal to the phospho-acceptor site, creating a better DAPK-1 peptide consensus and demonstrated that the Km for p531-66[ET--&gt;RR] and ATP is elevated.	Arginine	55-63	death associated protein kinase 1	Homo sapiens	132-138
17287625-4	2007	After 0-30 min 2.5 mol/l arginine (pH 8.6) Generated thrombin was detected by addition of CHG-Ala-Arg-pNA and measurement of triangle upA/t.	Arginine	25-33	coagulation factor II, thrombin	Homo sapiens	53-61
17197444-7	2007	In vitro and in NIH 3T3 cells in culture, the level of arginylated CRT increased with the addition of a Ca2+ chelator to the medium, whereas a decreased arginine incorporation into CRT was found in the presence of Ca2+.	Arginine	153-161	calreticulin	Mus musculus	181-184
17216278-4	2007	Glycation of apoA-I was quantified as the reduction in detectable arginine, lysine and tryptophan residues.	Arginine	66-74	apolipoprotein A1	Homo sapiens	13-19
17216278-9	2007	RESULTS: Methylglyoxal-mediated modifications of the arginine, lysine and tryptophan residues in lipid-free and lipid-associated apoA-I were time- and concentration-dependent.	Arginine	53-61	apolipoprotein A1	Homo sapiens	129-135
17069922-8	2007	Basal insulin secretory defects in type 2 diabetes may be estimated by the responses of insulin to glucagon and to arginine and the response of glucagon to arginine.	Arginine	115-123	insulin	Homo sapiens	6-13
17327334-8	2007	CONCLUSIONS: It is concluded that 1) raised fasting glucose (albeit still within normal values) augments baseline and maximal arginine-induced insulin secretion in healthy subjects, and 2) this is associated with reduced insulin sensitivity.	Arginine	126-134	insulin	Homo sapiens	143-150
17069922-8	2007	Basal insulin secretory defects in type 2 diabetes may be estimated by the responses of insulin to glucagon and to arginine and the response of glucagon to arginine.	Arginine	156-164	insulin	Homo sapiens	6-13
17417945-4	2007	Three polymorphisms of TGF-beta (713-8delC), i.e., C deletion in intron sequence 8 base prior to exon-5 by PCR-RFLP and codon-10, Leu/Pro, and codon-25, Arg/Pro by Amplification Refractory Mutation System (ARMS-PCR) techniques were genotyped in 228 end-stage renal disease (ESRD) patients and 180 controls.	Arginine	153-156	transforming growth factor beta 1	Homo sapiens	23-31
17192289-0	2007	Combining growth hormone releasing hormone-arginine and synacthen testing diminishes the cortisol response.	Arginine	43-51	growth hormone releasing hormone	Homo sapiens	10-42
17348731-4	2007	The central His-Phe-Arg-Trp tetrapeptide sequence of alpha-MSH is known to form a turn in the bioactive conformation.	Arginine	20-23	proopiomelanocortin	Homo sapiens	53-62
17327334-4	2007	From this test, the acute insulin response (AIR) to arginine during the three glucose levels (AIR1, AIR2, and AIR3) were estimated.	Arginine	52-60	insulin	Homo sapiens	26-33
17505150-2	2007	Asymmetric dimethylarginine (ADMA), a novel inhibitor of endothelial nitric oxide synthase (eNOS), blocks nitric oxide (NO) synthesis from L-arginine.	Arginine	139-149	nitric oxide synthase 3	Homo sapiens	57-90
17164427-3	2007	We evaluated fMLP-stimulated human neutrophil motility on peptides Arg-Gly-Asp-Ser (RGDS) and TMKIIPFNRTLIGG (P2), alone and in combination.	Arginine	67-70	formyl peptide receptor 1	Homo sapiens	13-17
17458594-15	2007	Administration of L-arginine and aprotinin led to suppression of the release of TNF-alpha, IL-1, and IL-6 during reperfusion in a statistically significant manner (all p &lt; 0.05).	Arginine	18-28	tumor necrosis factor	Homo sapiens	80-89
17458594-15	2007	Administration of L-arginine and aprotinin led to suppression of the release of TNF-alpha, IL-1, and IL-6 during reperfusion in a statistically significant manner (all p &lt; 0.05).	Arginine	18-28	interleukin 6	Homo sapiens	101-105
17427647-10	2007	Genetic analysis identified a change from Arg (CGT) at codon 201 to Cys (TGT).	Arginine	42-45	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	73-76
17266049-1	2007	High affinity peptide ligands for the bradykinin (BK) B(2) subtype receptor have been shown to adopt a beta-turn conformation of the C-terminal tetrapeptide (H-Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)-OH).	Arginine	160-163	kininogen 1	Homo sapiens	38-48
17311947-3	2007	GLP-2 infusion was hypothesized to increase the rate of endogenous arginine synthesis from proline, the major arginine precursor, in parenterally fed piglets receiving an arginine-deficient diet.	Arginine	67-75	glucagon	Homo sapiens	0-5
17311947-3	2007	GLP-2 infusion was hypothesized to increase the rate of endogenous arginine synthesis from proline, the major arginine precursor, in parenterally fed piglets receiving an arginine-deficient diet.	Arginine	110-118	glucagon	Homo sapiens	0-5
17311947-3	2007	GLP-2 infusion was hypothesized to increase the rate of endogenous arginine synthesis from proline, the major arginine precursor, in parenterally fed piglets receiving an arginine-deficient diet.	Arginine	110-118	glucagon	Homo sapiens	0-5
17311947-7	2007	Piglets receiving GLP-2 showed improvements in intestinal variables, including mucosal mass (P &lt; 0.01) and villus height (P &lt; 0.001), and a greater rate of arginine synthesis (micromol x kg(-1) x h(-1)) from proline (11.6 vs. 6.3) (P = 0.03).	Arginine	162-170	glucagon	Homo sapiens	18-23
17311947-9	2007	This study was the first to quantitate arginine synthesis in parenterally fed neonates and showed that although GLP-2 infusion increased arginine synthesis in a manner directly related to mucosal mass, this increased arginine synthesis was insufficient to improve whole-body arginine status in piglets receiving a low arginine diet.	Arginine	39-47	glucagon	Homo sapiens	112-117
17311947-9	2007	This study was the first to quantitate arginine synthesis in parenterally fed neonates and showed that although GLP-2 infusion increased arginine synthesis in a manner directly related to mucosal mass, this increased arginine synthesis was insufficient to improve whole-body arginine status in piglets receiving a low arginine diet.	Arginine	137-145	glucagon	Homo sapiens	112-117
17311947-9	2007	This study was the first to quantitate arginine synthesis in parenterally fed neonates and showed that although GLP-2 infusion increased arginine synthesis in a manner directly related to mucosal mass, this increased arginine synthesis was insufficient to improve whole-body arginine status in piglets receiving a low arginine diet.	Arginine	137-145	glucagon	Homo sapiens	112-117
17311947-9	2007	This study was the first to quantitate arginine synthesis in parenterally fed neonates and showed that although GLP-2 infusion increased arginine synthesis in a manner directly related to mucosal mass, this increased arginine synthesis was insufficient to improve whole-body arginine status in piglets receiving a low arginine diet.	Arginine	137-145	glucagon	Homo sapiens	112-117
17311947-9	2007	This study was the first to quantitate arginine synthesis in parenterally fed neonates and showed that although GLP-2 infusion increased arginine synthesis in a manner directly related to mucosal mass, this increased arginine synthesis was insufficient to improve whole-body arginine status in piglets receiving a low arginine diet.	Arginine	137-145	glucagon	Homo sapiens	112-117
17334331-8	2007	Second, we performed PCR analysis with peptide nucleic acid (PNA) for mutations at the Arg(201) codon of the alpha subunit of the stimulatory G protein gene (GNAS), which has reported to be a marker for extragnathic fibrous dysplasia.	Arginine	87-90	GNAS complex locus	Homo sapiens	158-162
17113648-2	2007	Cell surface DBP significantly enhances chemotactic activity of complement (C) peptides C5a and C5a des Arg.	Arginine	104-107	D-box binding PAR bZIP transcription factor	Homo sapiens	13-16
17113648-2	2007	Cell surface DBP significantly enhances chemotactic activity of complement (C) peptides C5a and C5a des Arg.	Arginine	104-107	complement C5a receptor 1	Homo sapiens	96-99
17334331-12	2007	Furthermore, PCR analysis with PNA for GNAS mutations at the Arg(201) codon is a useful method to differentiate between fibrous dysplasia and ossifying fibroma.	Arginine	61-64	GNAS complex locus	Homo sapiens	39-43
17223878-1	2007	BACKGROUND: p53 has a common polymorphism at amino acid 72, encoding either arginine or proline.	Arginine	76-84	tumor protein p53	Homo sapiens	12-15
17363510-4	2007	Subsequent cDNA sequence analysis revealed the latter tumor as expressing an EGFR sequence variant with arginine, rather than leucine, at amino acid position 62; this was the only EGFR sequence variant identified among the 11 xenografts, other than the aforementioned vIII sequence variant.	Arginine	104-112	epidermal growth factor receptor	Homo sapiens	77-81
17649707-6	2007	A heterozygous C to T mutation was found in the proband and three members of his family at nucleotide 5981 in exon 40 of MYH9 gene, resulting in a nonsense mutation which encoded truncated protein due to premature termination at the Arg 1933 codon.	Arginine	233-236	myosin heavy chain 9	Homo sapiens	121-125
17649707-8	2007	The Arg (CGA) 1933--&gt; stop (TGA) nonsense mutation in MYH9 gene is a causative genetic defect.	Arginine	4-7	myosin heavy chain 9	Homo sapiens	57-61
17023580-6	2007	Silencing of cyclin D3 reproduced the cell cycle arrest caused by L-Arg starvation.	Arginine	66-71	cyclin D3	Homo sapiens	13-22
17023580-7	2007	The regulation of cyclin D3 and cdk4 by L-Arg starvation occurs at transcriptional and posttranscriptional levels.	Arginine	40-45	cyclin D3	Homo sapiens	18-27
17023580-9	2007	Experiments demonstrated that T cells from GCN2 knock-out mice did not show a decreased proliferation and were able to up-regulate cyclin D3 when cultured in the absence of L-Arg.	Arginine	173-178	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	43-47
17460548-8	2007	Genotyping data showed that the 12-LOX Gln/Gln genotype was associated with increased risk of developing ESCC (odds ratio [OR]=1.42, 95% confidence interval [CI]=1.12-1.81), compared with the Arg/Arg genotype adjusted for sex, age, and smoking.	Arginine	192-195	arachidonate 15-lipoxygenase	Homo sapiens	32-38
17460548-8	2007	Genotyping data showed that the 12-LOX Gln/Gln genotype was associated with increased risk of developing ESCC (odds ratio [OR]=1.42, 95% confidence interval [CI]=1.12-1.81), compared with the Arg/Arg genotype adjusted for sex, age, and smoking.	Arginine	196-199	arachidonate 15-lipoxygenase	Homo sapiens	32-38
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Arginine	24-27	kininogen 1	Homo sapiens	68-78
17158873-1	2007	C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg.	Arginine	146-149	complement C5a receptor 2	Homo sapiens	0-4
17158873-1	2007	C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg.	Arginine	146-149	complement C5a receptor 1	Homo sapiens	98-101
17158873-1	2007	C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg.	Arginine	146-149	complement C5a receptor 1	Homo sapiens	138-141
17158873-2	2007	The classical human C5a receptor (C5aR) preferentially binds C5a, with a 10-100-fold lower affinity for C5a des Arg.	Arginine	112-115	complement C5a receptor 1	Homo sapiens	20-32
17158873-2	2007	The classical human C5a receptor (C5aR) preferentially binds C5a, with a 10-100-fold lower affinity for C5a des Arg.	Arginine	112-115	complement C5a receptor 1	Homo sapiens	34-38
17158873-2	2007	The classical human C5a receptor (C5aR) preferentially binds C5a, with a 10-100-fold lower affinity for C5a des Arg.	Arginine	112-115	complement C5a receptor 1	Homo sapiens	20-23
17158873-2	2007	The classical human C5a receptor (C5aR) preferentially binds C5a, with a 10-100-fold lower affinity for C5a des Arg.	Arginine	112-115	complement C5a receptor 1	Homo sapiens	34-37
17158873-5	2007	Here, we have investigated the molecular basis for the increased affinity of C5L2 for C5a des Arg.	Arginine	94-97	complement C5a receptor 2	Homo sapiens	77-81
17158873-5	2007	Here, we have investigated the molecular basis for the increased affinity of C5L2 for C5a des Arg.	Arginine	94-97	complement C5a receptor 1	Homo sapiens	86-89
17158873-8	2007	An antibody raised against the N terminus of human C5L2 did not affect the binding of C5a to C5L2 but did inhibit C5a des Arg binding.	Arginine	122-125	complement C5a receptor 2	Homo sapiens	51-55
17158873-8	2007	An antibody raised against the N terminus of human C5L2 did not affect the binding of C5a to C5L2 but did inhibit C5a des Arg binding.	Arginine	122-125	complement C5a receptor 1	Homo sapiens	114-117
17158873-10	2007	Mutation of acidic and tyrosine residues in the N terminus of human C5L2 revealed that 3 residues were critical for C5a des Arg binding but had little involvement in C5a binding.	Arginine	124-127	complement C5a receptor 2	Homo sapiens	68-72
17158873-10	2007	Mutation of acidic and tyrosine residues in the N terminus of human C5L2 revealed that 3 residues were critical for C5a des Arg binding but had little involvement in C5a binding.	Arginine	124-127	complement C5a receptor 1	Homo sapiens	116-119
17158873-11	2007	C5L2 thus appears to bind C5a and C5a des Arg by different mechanisms, and, unlike C5aR, C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.	Arginine	42-45	complement C5a receptor 2	Homo sapiens	0-4
17158873-11	2007	C5L2 thus appears to bind C5a and C5a des Arg by different mechanisms, and, unlike C5aR, C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.	Arginine	42-45	complement C5a receptor 1	Homo sapiens	34-37
17158873-11	2007	C5L2 thus appears to bind C5a and C5a des Arg by different mechanisms, and, unlike C5aR, C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.	Arginine	42-45	complement C5a receptor 1	Homo sapiens	34-37
17158873-11	2007	C5L2 thus appears to bind C5a and C5a des Arg by different mechanisms, and, unlike C5aR, C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.	Arginine	170-173	complement C5a receptor 2	Homo sapiens	0-4
17065601-4	2007	Our data suggest that l-arginine is taken up by Sertoli cells and peritubular cells, principally via system y(+)L (SLC3A2/SLC7A6) and system y(+) (SLC7A1 and SLC7A2), with system B(0+) making a minor contribution.	Arginine	22-32	solute carrier family 3 member 2	Rattus norvegicus	115-121
17065601-4	2007	Our data suggest that l-arginine is taken up by Sertoli cells and peritubular cells, principally via system y(+)L (SLC3A2/SLC7A6) and system y(+) (SLC7A1 and SLC7A2), with system B(0+) making a minor contribution.	Arginine	22-32	solute carrier family 7 member 6	Rattus norvegicus	122-128
17316105-5	2007	Insulin glulisine complements insulin glargine (21(A)-Gly30(Ba)-L-Arg-30(Bb)-L-Arg-human insulin), the first long-acting basal insulin analog that displays a smoothed time-action profile with a 24-h duration of action.	Arginine	77-82	insulin	Homo sapiens	89-96
17145192-5	2007	gACE was potently inhibited by EDTA, 1,10-phenanthroline, captopril and lisinopril, and it promptly released the dipeptides His-Leu and Phe-Arg from angiotensin I and bradykinin.	Arginine	140-143	angiotensinogen	Homo sapiens	149-162
17145192-5	2007	gACE was potently inhibited by EDTA, 1,10-phenanthroline, captopril and lisinopril, and it promptly released the dipeptides His-Leu and Phe-Arg from angiotensin I and bradykinin.	Arginine	140-143	kininogen 1	Homo sapiens	167-177
17316105-5	2007	Insulin glulisine complements insulin glargine (21(A)-Gly30(Ba)-L-Arg-30(Bb)-L-Arg-human insulin), the first long-acting basal insulin analog that displays a smoothed time-action profile with a 24-h duration of action.	Arginine	77-82	insulin	Homo sapiens	89-96
17316105-5	2007	Insulin glulisine complements insulin glargine (21(A)-Gly30(Ba)-L-Arg-30(Bb)-L-Arg-human insulin), the first long-acting basal insulin analog that displays a smoothed time-action profile with a 24-h duration of action.	Arginine	64-69	insulin	Homo sapiens	0-7
17316105-5	2007	Insulin glulisine complements insulin glargine (21(A)-Gly30(Ba)-L-Arg-30(Bb)-L-Arg-human insulin), the first long-acting basal insulin analog that displays a smoothed time-action profile with a 24-h duration of action.	Arginine	64-69	insulin	Homo sapiens	30-37
17709895-4	2007	Using BMI-related cut-off limits for peak GH response in the GHRH-arginine test, 4/16 beta-thalassemia patients had peak GH lower than 11.5 microg/l, the cut-off limit suggested for lean subjects, and were diagnosed as GH deficient (GHD).	Arginine	66-74	growth hormone 1	Homo sapiens	42-44
17316105-5	2007	Insulin glulisine complements insulin glargine (21(A)-Gly30(Ba)-L-Arg-30(Bb)-L-Arg-human insulin), the first long-acting basal insulin analog that displays a smoothed time-action profile with a 24-h duration of action.	Arginine	77-82	insulin	Homo sapiens	0-7
17709895-4	2007	Using BMI-related cut-off limits for peak GH response in the GHRH-arginine test, 4/16 beta-thalassemia patients had peak GH lower than 11.5 microg/l, the cut-off limit suggested for lean subjects, and were diagnosed as GH deficient (GHD).	Arginine	66-74	growth hormone releasing hormone	Homo sapiens	61-65
17709895-4	2007	Using BMI-related cut-off limits for peak GH response in the GHRH-arginine test, 4/16 beta-thalassemia patients had peak GH lower than 11.5 microg/l, the cut-off limit suggested for lean subjects, and were diagnosed as GH deficient (GHD).	Arginine	66-74	growth hormone 1	Homo sapiens	61-63
17289417-4	2007	DESIGN: We retrospectively reviewed the GHRH-arginine data of 77 FM patients with low serum IGF-I levels referred to our tertiary unit over a 4-year period.	Arginine	45-53	growth hormone releasing hormone	Homo sapiens	40-44
16979358-5	2007	Although differences exist in AAP sequence, there were three absolutely conserved amino acid residues in the predicted peptide, including an aspartic acid crucial for arginine-dependent regulation of arg-2 and CPA1.	Arginine	167-175	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	200-205
17289417-8	2007	CONCLUSION: Our data shows that a subpopulation of FM patients with low serum IGF-I levels will fail the GHRH-arginine test.	Arginine	110-118	growth hormone releasing hormone	Homo sapiens	105-109
17289417-8	2007	CONCLUSION: Our data shows that a subpopulation of FM patients with low serum IGF-I levels will fail the GHRH-arginine test.	Arginine	110-118	insulin like growth factor 1	Homo sapiens	78-83
17289417-10	2007	Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-I levels further supports the hypothesis of a dysregulated GH/IGF-I axis in the pathophysiology of FM.	Arginine	54-62	growth hormone 1	Homo sapiens	28-30
17291856-2	2007	Inducible nitric oxide synthase (iNOS), ornithine decarboxylase (ODC), and arginase I are involved in the arginine pathway.	Arginine	106-114	nitric oxide synthase 2	Homo sapiens	0-31
17289417-10	2007	Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-I levels further supports the hypothesis of a dysregulated GH/IGF-I axis in the pathophysiology of FM.	Arginine	54-62	growth hormone releasing hormone	Homo sapiens	49-53
17289417-10	2007	Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-I levels further supports the hypothesis of a dysregulated GH/IGF-I axis in the pathophysiology of FM.	Arginine	54-62	insulin like growth factor 1	Homo sapiens	121-126
17289417-10	2007	Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-I levels further supports the hypothesis of a dysregulated GH/IGF-I axis in the pathophysiology of FM.	Arginine	54-62	growth hormone 1	Homo sapiens	49-51
17289417-10	2007	Additionally, the increased GH response rates to GHRH-arginine stimulation in the majority of FM patients with low serum IGF-I levels further supports the hypothesis of a dysregulated GH/IGF-I axis in the pathophysiology of FM.	Arginine	54-62	insulin like growth factor 1	Homo sapiens	187-192
17096347-4	2007	Dietary arginine increased high-grade colon adenoma incidence in Apc(Min/+)Nos2(+/+) mice, but not in Nos2 knockout mice.	Arginine	8-16	nitric oxide synthase 2, inducible	Mus musculus	75-79
17012384-0	2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues.	Arginine	98-106	prion protein	Homo sapiens	72-75
17012384-8	2007	Furthermore, mutagenesis of Arg(107) and His(108) abolished plasminogen binding by Prp despite the presence of Lys(96) and Lys(101) in the binding site.	Arginine	28-31	prion protein	Homo sapiens	83-86
17110428-3	2007	Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner.	Arginine	209-217	interleukin 1 beta	Rattus norvegicus	172-180
17291856-2	2007	Inducible nitric oxide synthase (iNOS), ornithine decarboxylase (ODC), and arginase I are involved in the arginine pathway.	Arginine	106-114	nitric oxide synthase 2	Homo sapiens	33-37
17071614-7	2007	We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein.	Arginine	61-64	defensin beta 1	Homo sapiens	104-108
16720041-1	2007	l-Arginine is the common substrate for arginase and nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	52-73
17189474-5	2007	Prompted by this finding, we established that Rcd-1 can bind to single- and double-stranded oligonucleotides in vitro with the affinity of G/C/T &gt;&gt; A. Mutation of an arginine residue within the cleft strongly reduced or abolished oligonucleotide binding.	Arginine	172-180	RCD1	Homo sapiens	46-51
17369172-4	2007	Sequencing data showed that a single G to A substitution at nucleotide 263 occurred, resulting in amino acid change from Arg(CGA) to Gln(CAA) at position 62 of GPa protein.	Arginine	121-124	chromogranin A	Homo sapiens	125-128
17369172-4	2007	Sequencing data showed that a single G to A substitution at nucleotide 263 occurred, resulting in amino acid change from Arg(CGA) to Gln(CAA) at position 62 of GPa protein.	Arginine	121-124	glycophorin A (MNS blood group)	Homo sapiens	160-163
17110383-6	2007	KLK14 displayed trypsin-like specificity with high selectivity for P1-Arg over Lys.	Arginine	70-73	kallikrein related peptidase 14	Homo sapiens	0-5
17234578-2	2007	Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth.	Arginine	50-58	mechanistic target of rapamycin kinase	Homo sapiens	74-103
17234578-2	2007	Availability of nutrients, especially leucine and arginine, regulates the mammalian target of rapamycin (mTOR) pathway that controls cell growth.	Arginine	50-58	mechanistic target of rapamycin kinase	Homo sapiens	105-109
17198398-4	2007	Ime2 protein kinase assays with Sum1 mutants and synthetic peptides define a consensus Arg-Pro-X-Ser/Thr motif that is required for efficient phosphorylation by Ime2.	Arginine	87-90	protein kinase IME2	Saccharomyces cerevisiae S288C	0-4
17198398-4	2007	Ime2 protein kinase assays with Sum1 mutants and synthetic peptides define a consensus Arg-Pro-X-Ser/Thr motif that is required for efficient phosphorylation by Ime2.	Arginine	87-90	protein kinase IME2	Saccharomyces cerevisiae S288C	161-165
16968813-8	2007	Insulin secretion in response to arginine at maximally potentiating glucose levels (AIR(max)) tended to increase after metformin and to decrease after pioglitazone; however, when adjusted for S(I), the changes were not significant.	Arginine	33-41	insulin	Homo sapiens	0-7
17143054-4	2007	In addition, L-arginine infusion at rest increases plasma insulin, growth hormone, glucagon, catecholamines and prolactin.	Arginine	13-23	insulin	Homo sapiens	58-65
16622596-1	2007	The aim of this study was to evaluate the effect of pegylated interferon-alpha (PEG-IFN-alpha) on the plasma citrulline/arginine ratio, regarded as an index of nitric oxide (NO) synthesis, in patients with high-risk melanoma.	Arginine	120-128	interferon alpha 1	Homo sapiens	84-93
16622596-5	2007	Patients treated with PEG-IFN-alpha showed a significant decrease in the concentrations of citrulline and in the citrulline/arginine ratio during the whole study period, both compared to baseline values and to the control group.	Arginine	124-132	interferon alpha 1	Homo sapiens	26-35
17945002-0	2007	Implication of BRCA2 -26G&gt;A 5" untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg&gt;Pro polymorphism.	Arginine	146-149	tumor protein p53	Homo sapiens	133-136
17945002-9	2007	The p53 codon 72 Arg homozygous genotype was found to be over-represented in patients (P = 0.0005, OR = 2.3, 95% CI = 1.4 to 3.6).	Arginine	17-20	tumor protein p53	Homo sapiens	4-7
17143054-9	2007	SUMMARY: This line of research may have important therapeutic implications as there are indications that L-arginine augments the effects of exercise training on insulin sensitivity and capillary growth in muscles.	Arginine	105-115	insulin	Homo sapiens	161-168
16889625-7	2007	MALDI-MS and site-directed mutagenesis studies determined that ExoS ADP-ribosylated moesin at three C-terminal arginines (Arg553, Arg560 and Arg563), which cluster Thr558, the site of phosphorylation by protein kinase C and Rho kinase.	Arginine	111-120	moesin	Homo sapiens	84-90
17143054-4	2007	In addition, L-arginine infusion at rest increases plasma insulin, growth hormone, glucagon, catecholamines and prolactin.	Arginine	13-23	growth hormone 1	Homo sapiens	67-81
17010480-0	2007	Synthesis and evaluation of a small library of graftable thrombin inhibitors derived from (L)-arginine.	Arginine	90-102	coagulation factor II, thrombin	Homo sapiens	57-65
16978906-0	2007	Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity.	Arginine	45-53	transforming growth factor beta 1	Homo sapiens	99-131
18174711-3	2007	The most frequently used is the insulin tolerance test (ITT), followed in order by the arginine stimulation test (AST), the glucagon stimulation test (GST) and the GH-releasing hormone + arginine (GHRH+arg) test.	Arginine	187-195	growth hormone releasing hormone	Homo sapiens	197-201
18174749-3	2007	The most frequently used is the insulin tolerance test (ITT), followed in order by the arginine stimulation test (AST), the glucagon stimulation test (GST) and the GH-releasing hormone+arginine (GHRH+arg) test.	Arginine	185-193	growth hormone releasing hormone	Homo sapiens	195-199
16978906-8	2007	Arginine-glycine-aspartic acid-serine stimulated Phosphoinositol-3 kinase activity, and Transforming growth factor-beta1 promoter activation was abrogated by the use of Phosphoinositol-3 kinase specific inhibitors.	Arginine	0-8	transforming growth factor beta 1	Homo sapiens	88-120
17161229-6	2007	Insulin sensitivity was quantified by a hyperinsulinemic euglycemic clamp technique and expressed as M. M value, plasma homocysteine (Hcy) level, and asymmetric dimethyl-L-arginine (ADMA)/L-arginine ratio were independent determinants of CAD extent as shown by forward stepwise discriminant function analysis.	Arginine	170-180	insulin	Homo sapiens	0-7
16946027-10	2007	Together with the finding that endothelial cell ADMA protein expression was not increased in older adults, these findings suggest that competitive inhibition of l-arginine binding sites on endothelial nitric oxide synthase by ADMA is not an important mechanism contributing to impaired conduit artery endothelium-dependent dilation with aging in healthy humans.	Arginine	161-171	nitric oxide synthase 3	Homo sapiens	189-222
17936934-6	2007	PON1 is polymorphically distributed in human populations with an amino acid substitution (Gln/Arg) at position 192 of this 354-amino acid protein (the initiator Met residue is cleaved on maturation) that determines the catalytic efficiency of hydrolysis of some substrates.	Arginine	94-97	paraoxonase 1	Homo sapiens	0-4
18092562-4	2007	METHODS: GH stimulation testing was performed by the administration of intravenous arginine.	Arginine	83-91	growth hormone 1	Homo sapiens	9-11
17971359-1	2007	Nitric oxide (NO), a short-lived gaseous free radical, synthesized from L-arginine by NO synthases (NOS), is a potent mediator of biologic responses involved in the pathogenesis of autoimmune rheumatic diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).	Arginine	72-82	nitric oxide synthase 2	Homo sapiens	86-98
17368960-2	2007	NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	52-63
17368960-2	2007	NO is synthesized from L-arginine via the action of NO synthase (NOS), which is known to be blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA).	Arginine	114-124	nitric oxide synthase 2	Homo sapiens	52-63
17068344-2	2006	C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2).	Arginine	40-43	complement C5a receptor 1	Homo sapiens	0-3
16935537-3	2007	The elevated arginine levels induce the second arginase (AII) in patient kidney and kidney tissue culture.	Arginine	13-21	NLR family pyrin domain containing 3	Homo sapiens	57-60
17319790-11	2007	In the younger women group, the p53 BstUI polymorphism genotype frequencies were 6.2% for BstUIPro/Pro, 31.0% for BstUIArg/Pro and 62.8% for BstUIArg/Arg in controls and 11.11 %, 40.74% and 48.15% in cases respectively.	Arginine	119-122	tumor protein p53	Homo sapiens	32-35
17143486-5	2007	In vitro assays of this highly purified species, refolded in arginine rich conditions, confirmed that this unique, short version of MBD4 possessed uracil DNA glycosylase but not thymine DNA glycosylase activity.	Arginine	61-69	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	132-136
16842840-1	2007	INTRODUCTION: Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7.	Arginine	72-82	nitric oxide synthase 3	Homo sapiens	86-119
16842840-1	2007	INTRODUCTION: Endothelium-derived nitric oxide (NO) is synthesized from l-arginine by endothelial nitric oxide synthase (eNOS) encoded by the eNOS3 gene on chromosome 7.	Arginine	72-82	nitric oxide synthase 3	Homo sapiens	121-125
17408725-0	2007	Fibrinogen Novy Jicin and Praha II: cases of hereditary Aalpha 16 Arg--&gt;Cys and Aalpha 16 Arg--&gt;His dysfibrinogenemia.	Arginine	66-69	fibrinogen beta chain	Homo sapiens	0-10
17408725-0	2007	Fibrinogen Novy Jicin and Praha II: cases of hereditary Aalpha 16 Arg--&gt;Cys and Aalpha 16 Arg--&gt;His dysfibrinogenemia.	Arginine	93-96	fibrinogen beta chain	Homo sapiens	0-10
16169754-0	2007	L-arginine prevents reduced expression of endothelial nitric oxide synthase (NOS) in pulmonary arterioles of broilers exposed to cool temperatures.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	42-75
17032651-3	2006	In the present study, we have used a phage display approach to affinity-optimize the C-terminal linear region of EGF-like growth factors for binding to each ErbB receptor and thereby shown that Arg(45) in EGF impairs binding to both ErbB3 and ErbB4.	Arginine	194-197	epidermal growth factor receptor	Homo sapiens	157-161
17189187-4	2006	Mutation of K120 to arginine, as occurs in human cancer, debilitates K120 acetylation and diminishes p53-mediated apoptosis without affecting cell-cycle arrest.	Arginine	20-28	tumor protein p53	Homo sapiens	101-104
17020886-1	2006	Membrane-bound factor Xa alone catalyzes prothrombin activation following initial cleavage at Arg(271) and prethrombin 2 formation (pre2 pathway).	Arginine	94-97	coagulation factor II, thrombin	Homo sapiens	41-52
17020886-2	2006	Factor Va directs prothrombin activation by factor Xa through the meizothrombin pathway, characterized by initial cleavage at Arg(320) (meizo pathway).	Arginine	126-129	coagulation factor II, thrombin	Homo sapiens	18-29
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Arginine	28-36	integrin linked kinase	Homo sapiens	76-98
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Arginine	28-36	transforming growth factor beta 1	Homo sapiens	234-266
17266136-5	2007	These responses were potently reduced by the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG, 30 microM) and further reversed by the NO synthesis substrate L-arginine (L-ARG, 3 mM).	Arginine	92-102	nitric oxide synthase 2	Sus scrofa	45-66
17266136-5	2007	These responses were potently reduced by the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG, 30 microM) and further reversed by the NO synthesis substrate L-arginine (L-ARG, 3 mM).	Arginine	187-192	nitric oxide synthase 2	Sus scrofa	45-66
17141371-2	2007	Whereas the enticin cDNA predicts a 69-residue mature protein, enticin isolated from the albumen gland was found to be posttranslationally processed in vivo by cleavage at Arg(50) residue to generate a smaller 49-residue mature peptide.	Arginine	172-175	enticin	Aplysia californica	63-70
17141371-3	2007	The Arg(50) cleavage site is conserved in enticin from both Aplysia californica and Aplysia brasiliana.	Arginine	4-7	enticin	Aplysia californica	42-49
17020886-7	2006	These data demonstrate that the peptide preferentially inhibits initial cleavage of prothrombin by prothrombinase at Arg(320).	Arginine	117-120	coagulation factor II, thrombin	Homo sapiens	84-95
17020886-8	2006	These findings were corroborated by studying the activation of recombinant mutant prothrombin molecules rMZ-II (R155A/R284A/R271A) and rP2-II (R155A/R284A/R320A) which can be only cleaved at Arg(320) and Arg(271), respectively.	Arginine	191-194	coagulation factor II, thrombin	Homo sapiens	82-93
17020886-8	2006	These findings were corroborated by studying the activation of recombinant mutant prothrombin molecules rMZ-II (R155A/R284A/R271A) and rP2-II (R155A/R284A/R320A) which can be only cleaved at Arg(320) and Arg(271), respectively.	Arginine	204-207	coagulation factor II, thrombin	Homo sapiens	82-93
17020886-10	2006	The pentapeptide also interfered with prothrombin cleavage by membrane-bound factor Xa alone in the absence of factor Va increasing the rate for cleavage at Arg(271) of plasma-derived prothrombin or rP2-II.	Arginine	157-160	coagulation factor II, thrombin	Homo sapiens	38-49
17020886-10	2006	The pentapeptide also interfered with prothrombin cleavage by membrane-bound factor Xa alone in the absence of factor Va increasing the rate for cleavage at Arg(271) of plasma-derived prothrombin or rP2-II.	Arginine	157-160	coagulation factor II, thrombin	Homo sapiens	184-195
17068344-2	2006	C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2).	Arginine	40-43	complement C5a receptor 1	Homo sapiens	32-35
17068344-2	2006	C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2).	Arginine	40-43	complement C5a receptor 2	Homo sapiens	65-84
17068344-2	2006	C5a and its degradation product C5a-des-Arg(74) also bind to the C5a receptor-like 2 (C5L2).	Arginine	40-43	complement C5a receptor 2	Homo sapiens	86-90
17028019-2	2006	We demonstrated previously that two type II metacaspases of Arabidopsis thaliana, AtMC4 and AtMC9 are Arg/Lys-specific cysteine-dependent proteases.	Arginine	102-105	metacaspase 9	Arabidopsis thaliana	92-97
17176473-3	2006	RESULTS: Here, we report the methylation of Rev due to a single arginine dimethylation in the N-terminal portion of its arginine rich motif and the association of Rev with PRMT6 in vivo.	Arginine	64-72	protein arginine methyltransferase 6	Homo sapiens	172-177
17176473-3	2006	RESULTS: Here, we report the methylation of Rev due to a single arginine dimethylation in the N-terminal portion of its arginine rich motif and the association of Rev with PRMT6 in vivo.	Arginine	120-128	protein arginine methyltransferase 6	Homo sapiens	172-177
17176473-7	2006	Binding of the Rev arginine rich motif to the RRE was reduced in the presence of wild-type PRMT6, whereas mutant PRMT6 did not exert this negative effect.	Arginine	19-27	protein arginine methyltransferase 6	Homo sapiens	91-96
17146059-2	2006	Cleavage of the Tyr(1605)-Met(1606) scissile bond in the VWF A2 domain depends on a Glu(1660)-Arg(1668) segment in the same domain and on the noncatalytic spacer domain of ADAMTS13, suggesting that extensive enzyme-substrate interactions facilitate substrate recognition.	Arginine	94-97	von Willebrand factor	Homo sapiens	57-60
17075694-0	2006	L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells.	Arginine	0-10	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	74-113
17122583-0	2006	Heme oxygenase 1, nuclear factor E2-related factor 2, and nuclear factor kappaB are involved in hemin inhibition of type 2 cationic amino acid transporter expression and L-Arginine transport in stimulated macrophages.	Arginine	170-180	heme oxygenase 1	Mus musculus	0-52
17122583-0	2006	Heme oxygenase 1, nuclear factor E2-related factor 2, and nuclear factor kappaB are involved in hemin inhibition of type 2 cationic amino acid transporter expression and L-Arginine transport in stimulated macrophages.	Arginine	170-180	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-79
17075694-6	2006	L-arginine competitively inhibited DDAH enzyme activity to 5.6 +/- 2.0% of the untreated level (p &lt; 0.01).	Arginine	0-10	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	35-39
17075694-7	2006	We conclude that L-arginine regulates ADMA metabolism dose-dependently by competing for DDAH thus maintaining the metabolic balance of L-arginine and ADMA, and endothelial NO homeostasis.	Arginine	17-27	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	88-92
17075694-7	2006	We conclude that L-arginine regulates ADMA metabolism dose-dependently by competing for DDAH thus maintaining the metabolic balance of L-arginine and ADMA, and endothelial NO homeostasis.	Arginine	135-145	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	88-92
16924660-1	2006	L-Arginine transport and nitric oxide (NO) synthesis (L-arginine/NO pathway) are stimulated by insulin, adenosine or elevated extracellular D-glucose in human umbilical vein endothelial cells (HUVEC).	Arginine	0-10	insulin	Homo sapiens	95-102
17210980-3	2006	Both clonidine, an alpha(2)-adrenoceptor agonist, and arginine, an amino acid activating the cholinergic system, have been used to assess growth hormone response in patients with IPD and MSA.	Arginine	54-62	growth hormone 1	Homo sapiens	138-152
16836770-8	2006	Inducible NO synthase (iNOS) expression was monitored by RT-PCR and iNOS activity by conversion of l-arginine to citrulline.	Arginine	99-109	nitric oxide synthase 2, inducible	Mus musculus	23-27
17212781-2	2006	Substrates are targeted to the Tat pathway by signal peptides containing a pair of consecutive arginine residues.	Arginine	95-103	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	31-34
17212781-10	2006	These data show that the twin-arginine residues of the Tat consensus motif are not essential for binding of precursor to the TatBC complex but are required for the successful entry of the precursor into the transport cycle.	Arginine	30-38	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	55-58
17287556-1	2006	BACKGROUND &amp; OBJECTIVES: Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.	Arginine	80-90	nitric oxide synthase 3	Homo sapiens	129-133
17287556-1	2006	BACKGROUND &amp; OBJECTIVES: Endo-derived nitric oxide (NO) is synthesized from L-arginine by endothelium nitric oxide synthase (eNOS) encoded by the NOS3 gene on chromosome7.	Arginine	80-90	nitric oxide synthase 3	Homo sapiens	150-154
16924660-1	2006	L-Arginine transport and nitric oxide (NO) synthesis (L-arginine/NO pathway) are stimulated by insulin, adenosine or elevated extracellular D-glucose in human umbilical vein endothelial cells (HUVEC).	Arginine	54-64	insulin	Homo sapiens	95-102
17209781-6	2006	The TGF-beta1 (codon 25) GG (Arg(25)/Arg(25)) genotype was detected more frequently in control subjects than in periodontitis patients (OR = 0.459; 95% CI = 0.230 to 0.920; P = 0.0421).	Arginine	29-32	transforming growth factor beta 1	Homo sapiens	4-13
17209781-6	2006	The TGF-beta1 (codon 25) GG (Arg(25)/Arg(25)) genotype was detected more frequently in control subjects than in periodontitis patients (OR = 0.459; 95% CI = 0.230 to 0.920; P = 0.0421).	Arginine	37-40	transforming growth factor beta 1	Homo sapiens	4-13
16765619-0	2006	Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: role of Th1/Th2 cytokine balance.	Arginine	0-8	negative elongation factor complex member C/D, Th1l	Mus musculus	98-101
17116549-6	2006	Endothelial nitric oxide synthase (eNOS) activity was assayed by measuring conversion of L-arginine to L-citrulline.	Arginine	89-99	nitric oxide synthase 3	Homo sapiens	0-33
16765619-6	2006	The elevated levels of Th(1) cytokines, namely TNF-alpha, IL-1beta, IFN-gamma, nitrite, and iNOS, decreased significantly both at +4 and +24 h of WBH, following L-arg administration.	Arginine	161-166	interferon gamma	Mus musculus	68-77
17176450-2	2006	This results in a single amino acid exchange depending on the closest related allele investigated, whether DRB*1103 codon 74 alanine (GCG) is changed to leucine (CTG) or DRB1*1125 codon 71 arginine (GAG) is replaced with glutamic acid.	Arginine	189-197	major histocompatibility complex, class II, DR beta 1	Homo sapiens	170-174
16981237-12	2006	According to CMEPS, residues Leu A16, Tyr A19, Leu B11, Leu B15, and Arg B22 are most important for the stability of the monomeric insulin fold.	Arginine	69-72	insulin	Homo sapiens	131-138
17415970-10	2006	A mutation of C to T was detected by sequencing at the nucleotide 1080 that converts the Arg codon (CGA) to a termination codon (TGA).	Arginine	89-92	chromogranin A	Homo sapiens	100-103
16916529-5	2006	Within this domain, highly conserved lysine and arginine residues significantly contributed to Nef"s membrane association and localization.	Arginine	48-56	S100 calcium binding protein B	Homo sapiens	95-98
17002658-7	2006	RESULTS: A novel, heterozygous point mutation (g.1755 G &gt; A, named prothrombin-Edmonton) was detected in the patient and his mother, resulting in the mutation of Arg-4 in the prothrombin propeptide to Gln (R-4Q).	Arginine	165-168	coagulation factor II, thrombin	Homo sapiens	70-81
17123452-6	2006	When evaluated by several pathway and biological process analysis programs, these proteins are demonstrated to be involved with a high degree of confidence (p values &lt; 2.0 E-05) in glycolysis, propanoate metabolism, pyruvate metabolism, urea cycle and arginine/proline metabolism, as well as in the non-metabolic p53 and FAS pathways.	Arginine	255-263	tumor protein p53	Homo sapiens	316-319
17002658-7	2006	RESULTS: A novel, heterozygous point mutation (g.1755 G &gt; A, named prothrombin-Edmonton) was detected in the patient and his mother, resulting in the mutation of Arg-4 in the prothrombin propeptide to Gln (R-4Q).	Arginine	165-168	coagulation factor II, thrombin	Homo sapiens	178-189
17005568-2	2006	Although the enzyme responsible for the modification reaction at arginine 66 has been identified (Rmt2), the enzyme(s) responsible for the lysine modification(s) has not been found, and the site(s) of methylation has not been determined.	Arginine	65-73	protein-arginine N5-methyltransferase	Saccharomyces cerevisiae S288C	98-102
16990264-8	2006	The galectin-9 NCRD can bind both N-acetyllactosamine (Galbeta1-4GlcNAc) and T-antigen (Galbeta1-3GalNAc) with the proper location of Arg-64.	Arginine	134-137	lectin, galactose binding, soluble 9	Mus musculus	4-14
16997880-2	2006	Fetal NOS-3 activity, measured as NO production with 0.5-0.9 microM 4-amino-5-methylamino-2,7-difluorofluorescein, was decreased in hypoxia by 14.4% (P &lt; 0.01), inhibitable by the NOS inhibitor N-nitro-L-arginine, and dependent on extracellular arginine.	Arginine	207-215	nitric oxide synthase 3	Homo sapiens	6-11
17098864-1	2006	The revertant mutations G550E and 4RK [the simultaneous mutation of four arginine-framed tripeptides (AFTs): R29K, R516K, R555K, and R766K] rescue the cell surface expression and function of F508del-cystic fibrosis (CF) transmembrane conductance regulator (-CFTR), the most common CF mutation.	Arginine	73-81	CF transmembrane conductance regulator	Homo sapiens	258-262
16931513-7	2006	Furthermore, we identified the site of ADP-ribose polymer attachment on ART2 as Arg-185, an arginine in a crucial loop of its catalytic core.	Arginine	80-83	ADP-ribosyltransferase 2b	Rattus norvegicus	72-76
16931513-7	2006	Furthermore, we identified the site of ADP-ribose polymer attachment on ART2 as Arg-185, an arginine in a crucial loop of its catalytic core.	Arginine	92-100	ADP-ribosyltransferase 2b	Rattus norvegicus	72-76
16772327-0	2006	Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients.	Arginine	39-49	insulin	Homo sapiens	128-135
16772327-1	2006	Because chronic L-arginine supplementation improves insulin sensitivity and endothelial function in nonobese type 2 diabetic patients, the aim of this study was to evaluate the effects of a long-term oral L-arginine therapy on adipose fat mass (FM) and muscle free-fat mass (FFM) distribution, daily glucose levels, insulin sensitivity, endothelial function, oxidative stress, and adipokine release in obese type 2 diabetic patients with insulin resistance who were treated with a combined period of hypocaloric diet and exercise training.	Arginine	16-26	insulin	Homo sapiens	52-59
16772327-6	2006	Long-term oral L-arginine treatment resulted in an additive effect compared with a diet and exercise training program alone on glucose metabolism and insulin sensitivity.	Arginine	15-25	insulin	Homo sapiens	150-157
17183946-5	2006	The +2044G/A mutation, which encodes an IL-13 protein with glutamine instead of arginine, has been associated with various inflammatory conditions.	Arginine	80-88	interleukin 13	Homo sapiens	40-45
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	200-207	coagulation factor II, thrombin	Homo sapiens	58-66
17043152-3	2006	Here we use site-directed mutagenesis to identify arginine residues contributing important surface charges in the intracellular mouth of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel pore.	Arginine	50-58	CF transmembrane conductance regulator	Homo sapiens	141-192
17043152-3	2006	Here we use site-directed mutagenesis to identify arginine residues contributing important surface charges in the intracellular mouth of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel pore.	Arginine	50-58	CF transmembrane conductance regulator	Homo sapiens	194-198
17043152-4	2006	While wild-type CFTR was associated with a linear current-voltage relationship with symmetrical solutions, strong outward rectification was observed after mutagenesis of two arginine residues (R303 and R352) located near the intracellular ends of the fifth and sixth transmembrane regions.	Arginine	174-182	CF transmembrane conductance regulator	Homo sapiens	16-20
17043152-11	2006	These results suggest that positively charged arginine residues act to concentrate Cl(-) ions at the inner mouth of the CFTR pore, and that this contributes to maximization of the rate of Cl(-) ion permeation through the pore.	Arginine	46-54	CF transmembrane conductance regulator	Homo sapiens	120-124
17052961-12	2006	This can be realized by supplementing co-factors, e.g., BH4, or substrate, L-arginine, by increasing cGMP availability via phosphodiesterase inhibitors or sGC activators or by increasing NO bioavailability via antioxidants.	Arginine	75-85	sarcoglycan beta	Homo sapiens	155-158
17177838-8	2006	In conclusion, based on the findings of this study, it is suggested that p53 Arg homozygosity could act as a potential risk factor for the tumorigenesis of the cervix.	Arginine	77-80	tumor protein p53	Homo sapiens	73-76
17177838-10	2006	p53 Arg homozygosity and HR-HPV E6 positive simultaneously can predict the fate of cervical lesions.	Arginine	4-7	tumor protein p53	Homo sapiens	0-3
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	200-207	coagulation factor II, thrombin	Homo sapiens	154-162
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	228-231	coagulation factor II, thrombin	Homo sapiens	58-66
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	228-231	coagulation factor II, thrombin	Homo sapiens	154-162
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	236-239	coagulation factor II, thrombin	Homo sapiens	58-66
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	236-239	coagulation factor II, thrombin	Homo sapiens	154-162
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	236-239	coagulation factor II, thrombin	Homo sapiens	58-66
21155281-7	2006	The eNOS downregulation and iNOS upregulation among I/R, L-Arg and AG groups were observed contrasted to the control group.	Arginine	57-62	nitric oxide synthase 2	Rattus norvegicus	28-32
17494315-14	2006	It is admitted on the basis of already obtained data that thrombin binding with organic ligands proceeds at the expense of anionic area of beta-domain of thrombin active centre where basic aminoacids arginin and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.)	Arginine	236-239	coagulation factor II, thrombin	Homo sapiens	154-162
16923805-3	2006	Substitutions at Arg(20) reduced affinity for the intact PTHR by 200-fold or more, but altered affinity for PTHR-delNt by 4-fold or less.	Arginine	17-20	parathyroid hormone 1 receptor	Homo sapiens	57-61
16923805-3	2006	Substitutions at Arg(20) reduced affinity for the intact PTHR by 200-fold or more, but altered affinity for PTHR-delNt by 4-fold or less.	Arginine	17-20	parathyroid hormone 1 receptor	Homo sapiens	108-112
16923805-6	2006	Thus, the side chains of Arg(20), together with those composing the hydrophobic face of the ligand"s putative amphiphilic alpha-helix, contribute strongly to PTHR-binding affinity by interacting specifically with the N domain of the receptor.	Arginine	25-28	parathyroid hormone 1 receptor	Homo sapiens	158-162
16943202-3	2006	The conjugation of Arg is mediated by arginyltransferase, encoded by ATE1.	Arginine	19-22	arginyltransferase 1	Mus musculus	69-73
17052457-5	2006	Second, PRMT1 is recruited to the HNF4 ligand-binding domain (LBD) through a mechanism that involves the p160 family of coactivators and methylates histone H4 at arginine 3.	Arginine	162-170	hepatocyte nuclear factor 4 alpha	Homo sapiens	34-38
17042490-5	2006	The chelators also protected the SOD activity against inhibition by the arginine-specific reagent, phenylglyoxal.	Arginine	72-80	superoxide dismutase 1	Homo sapiens	33-36
17052457-5	2006	Second, PRMT1 is recruited to the HNF4 ligand-binding domain (LBD) through a mechanism that involves the p160 family of coactivators and methylates histone H4 at arginine 3.	Arginine	162-170	MYB binding protein 1a	Homo sapiens	105-109
17015747-8	2006	Pharmacological supplementation with l-arginine or with NO donors amplified or attenuated IL-13-induced AHR, respectively.	Arginine	37-47	interleukin 13	Homo sapiens	90-95
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Arginine	97-100	tumor protein p53	Homo sapiens	93-96
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Arginine	198-201	tumor protein p53	Homo sapiens	93-96
16721787-3	2006	Among 856 colorectal adenoma cases and 1,184 controls, we observed a modest association with p53 Arg72Pro genotype (multivariate odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.04-1.50 for Arg/Pro and Pro/Pro vs. Arg/Arg).	Arginine	198-201	tumor protein p53	Homo sapiens	93-96
17015747-10	2006	These data suggest an important role for metabolism of l-arginine by arginase I in the modulation of IL-13-induced AHR and identify a potential pathway distal to cytokine receptor interactions for the control of IL-13-mediated bronchoconstriction in asthma.	Arginine	55-65	interleukin 13	Homo sapiens	101-106
16873402-8	2006	These findings suggest that beta(2)AR-mediated NOS-3 activation in HUVEC is mediated through phosphorylation of NOS-3 on serine-1177 through both the PKA and the PI3K/Akt systems, and is sustained by an increase in l-arginine uptake resulting from NO-mediated membrane hyperpolarization.	Arginine	215-225	nitric oxide synthase 3	Homo sapiens	47-52
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Arginine	42-45	peroxisome proliferator activated receptor gamma	Homo sapiens	218-266
16873402-8	2006	These findings suggest that beta(2)AR-mediated NOS-3 activation in HUVEC is mediated through phosphorylation of NOS-3 on serine-1177 through both the PKA and the PI3K/Akt systems, and is sustained by an increase in l-arginine uptake resulting from NO-mediated membrane hyperpolarization.	Arginine	215-225	nitric oxide synthase 3	Homo sapiens	112-117
16908518-4	2006	We report that Smad10 is a mutant form of Smad4beta that harbors a missense mutation of a conserved arginine to histidine in the MH1 domain.	Arginine	100-108	SMAD family member 4, gene 2 L homeolog	Xenopus laevis	15-21
16908518-4	2006	We report that Smad10 is a mutant form of Smad4beta that harbors a missense mutation of a conserved arginine to histidine in the MH1 domain.	Arginine	100-108	SMAD family member 4, gene 2 L homeolog	Xenopus laevis	42-51
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Arginine	42-45	peroxisome proliferator activated receptor gamma	Homo sapiens	268-277
16945493-0	2006	Mutations of connexin 26 at position 75 and dominant deafness: essential role of arginine for the generation of functional gap-junctional channels.	Arginine	81-89	gap junction protein beta 2	Homo sapiens	13-24
16893894-5	2006	This resulted in the identification of four residues crucial for TLR2/1 signaling: Arg-748, Phe-749, Leu-752, and Arg-753.	Arginine	83-86	toll like receptor 2	Homo sapiens	65-71
16893894-5	2006	This resulted in the identification of four residues crucial for TLR2/1 signaling: Arg-748, Phe-749, Leu-752, and Arg-753.	Arginine	114-117	toll like receptor 2	Homo sapiens	65-71
16893894-7	2006	In Region I, residues Arg-748 and Phe-749 in TLR2 DD loop were involved in close contacts with Gly-676 in the TLR1 BB loop.	Arginine	22-25	toll like receptor 2	Homo sapiens	45-49
16893894-7	2006	In Region I, residues Arg-748 and Phe-749 in TLR2 DD loop were involved in close contacts with Gly-676 in the TLR1 BB loop.	Arginine	22-25	toll like receptor 1	Homo sapiens	110-114
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Arginine	322-325	metallothionein 1A	Homo sapiens	59-63
16955215-5	2006	The screening in the present paper of two polymorphisms in MT1a gene has revealed for the first time that the polymorphism corresponding to a A/C (Asp/Thr) transition at 647 nt position in the Mt1a coding region is the more involved in the longevity, at least in old women, rather than the other corresponding to A/G (Lys/Arg) transition at 1,245 nt position.	Arginine	322-325	metallothionein 1A	Homo sapiens	193-197
16876149-3	2006	RESULTS: The NO donors (+/-)-S-Nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside, a NO solution, and l-Arginine inhibited hKv1.5 currents in a concentration-dependent manner.	Arginine	113-123	potassium voltage-gated channel subfamily A member 5	Homo sapiens	134-140
16984242-15	2006	CONCLUSIONS: Adult subjects with PWS had a reduced responsiveness to GHRH + ARG administration associated with reduced IGF-I levels.	Arginine	76-79	insulin like growth factor 1	Homo sapiens	119-124
16926162-6	2006	We predicted that an arginine residue in the TM segments predicted to line the drug-binding pocket of P-gp (I306(TM5) or F343(TM6)) might suppress DeltaY490 P-gp protein misfolding because it has the highest propensity to form hydrogen bonds.	Arginine	21-29	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
16926162-6	2006	We predicted that an arginine residue in the TM segments predicted to line the drug-binding pocket of P-gp (I306(TM5) or F343(TM6)) might suppress DeltaY490 P-gp protein misfolding because it has the highest propensity to form hydrogen bonds.	Arginine	21-29	ATP binding cassette subfamily B member 1	Homo sapiens	157-161
17214603-1	2006	L-citrulline is the natural precursor of L-arginine, substrate for nitric oxide synthase (NOS) in the production of NO.	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	67-88
16990654-2	2006	The GHRH + arginine (GHRH + ARG) test has been recommended as a reliable alternative to the insulin-tolerance test (ITT) as a standard test with a cutoff level of 9 ng/ml.	Arginine	11-19	growth hormone releasing hormone	Homo sapiens	21-25
16990654-2	2006	The GHRH + arginine (GHRH + ARG) test has been recommended as a reliable alternative to the insulin-tolerance test (ITT) as a standard test with a cutoff level of 9 ng/ml.	Arginine	28-31	growth hormone releasing hormone	Homo sapiens	4-8
16945493-9	2006	Our results show that the arginine located at position 75 of connexin 26 is essential for function, and cannot be replaced by other residues.	Arginine	26-34	gap junction protein beta 2	Homo sapiens	61-72
17075778-3	2006	The nitric oxide synthase (NOS) oxidizes L-arginine to nitric oxide (NO).	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	4-25
17016554-4	2006	After this triggering event, MSCs express 2 enzymes involved in l-arginine metabolism, Arginase I and iNOS, whose metabolic products include diffusible and highly reactive peroxynitrites, the ultimate biochemical mediators of T cell immune suppression.	Arginine	64-74	nitric oxide synthase 2	Homo sapiens	102-106
17062343-0	2006	[Highly selective inhibition of inducible nitric oxide synthase in vitro by a tripeptide as a new arginine analog].	Arginine	98-106	nitric oxide synthase 2	Homo sapiens	32-63
16982895-6	2006	A central cluster of hydrophilic CD1d residues (Asp(153), Thr(156), Ser(76), Arg(79)) interacts with the phosphate, inositol, and alpha1-alpha6-linked mannose of the headgroup, whereas additional specificity for the alpha1- and alpha2-linked mannose is conferred by Thr(159).	Arginine	77-80	CD1d1 antigen	Mus musculus	33-37
17061019-7	2006	ARG induced a prompt but transient increase (P &lt; 0.05) of insulin and glucose (P &lt; 0.01), without modifying ghrelin secretion.	Arginine	0-3	insulin	Homo sapiens	61-68
17062343-1	2006	OBJECTIVE: To investigate the inhibitory effect of a tripeptide, a new arginine analog, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS).	Arginine	71-79	nitric oxide synthase 2	Homo sapiens	124-155
17062343-2	2006	METHODS: Macrophages challenged with lipopolysaccharide were cultured to test the inhibitory effect of the arginine analog of different concentrations on iNOS.	Arginine	107-115	nitric oxide synthase 2	Homo sapiens	154-158
17062352-2	2006	It was found that the p53 gene condon 282 mutation (Arg/Leu) may destabilize the H2 helix and DNA binding in the major groove by compromising the contacts of p53 protein with the beta-hairpin of DNA binding surface.	Arginine	52-55	tumor protein p53	Homo sapiens	22-25
17062352-2	2006	It was found that the p53 gene condon 282 mutation (Arg/Leu) may destabilize the H2 helix and DNA binding in the major groove by compromising the contacts of p53 protein with the beta-hairpin of DNA binding surface.	Arginine	52-55	tumor protein p53	Homo sapiens	158-161
16912968-4	2006	With this combined approach we were able to detect nine calcium-dependent interactions between Arg-Gly-Ser-(RGS)-His6 tagged proteins derived from the library and GST-tagged S100B and S100A6, respectively.	Arginine	95-98	S100 calcium binding protein B	Homo sapiens	174-179
16912968-4	2006	With this combined approach we were able to detect nine calcium-dependent interactions between Arg-Gly-Ser-(RGS)-His6 tagged proteins derived from the library and GST-tagged S100B and S100A6, respectively.	Arginine	95-98	S100 calcium binding protein A6	Homo sapiens	184-190
16809339-7	2006	EPR and structural data suggest that membrane interaction of COX-2 is also aided by partitioning of 4 aromatic amino acids, Phe(59), Phe(66), Tyr(76), and Phe(84) to the interfacial region, and by the electrostatic interactions of two basic amino acids, Arg(62) and Lys(64), with the phospholipid head groups.	Arginine	254-257	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
17007666-5	2006	DNA was extracted from the buccal swabs obtained from 70 women experiencing implantation failure and polymerase chain reaction amplification of p53 arginine (Arg) 72 and proline (Pro) 72 variants were performed.	Arginine	148-156	tumor protein p53	Homo sapiens	144-147
16919264-3	2006	In guinea pig trachea, L-arginine is a limiting factor in neuronal nNOS-mediated airway smooth muscle relaxation upon inhibitory nonadrenergic noncholinergic (iNANC) nerve stimulation.	Arginine	23-33	nitric oxide synthase, brain	Cavia porcellus	67-71
16919264-10	2006	In conclusion, the L-citrulline/L-arginine cycle is operative in guinea pig iNANC nerves in the airways and may be effective under conditions of low L-arginine utilization by nNOS (caused by NOS inhibitors), and during reduced L-arginine availability after allergen challenge.	Arginine	32-42	nitric oxide synthase, brain	Cavia porcellus	175-179
16919264-10	2006	In conclusion, the L-citrulline/L-arginine cycle is operative in guinea pig iNANC nerves in the airways and may be effective under conditions of low L-arginine utilization by nNOS (caused by NOS inhibitors), and during reduced L-arginine availability after allergen challenge.	Arginine	149-159	nitric oxide synthase, brain	Cavia porcellus	175-179
16919264-10	2006	In conclusion, the L-citrulline/L-arginine cycle is operative in guinea pig iNANC nerves in the airways and may be effective under conditions of low L-arginine utilization by nNOS (caused by NOS inhibitors), and during reduced L-arginine availability after allergen challenge.	Arginine	149-159	nitric oxide synthase, brain	Cavia porcellus	175-179
16310306-0	2006	TEL/ARG induces cytoskeletal abnormalities in 293T cells.	Arginine	4-7	ETS variant transcription factor 6	Homo sapiens	0-3
16861234-2	2006	Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation.	Arginine	35-38	estrogen receptor 1	Homo sapiens	140-142
16861234-2	2006	Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation.	Arginine	35-38	estrogen receptor 1	Homo sapiens	144-161
16310306-1	2006	We previously identified TEL/ARG as a novel fusion transcript consisting of the oligomerization domain of TEL and the kinase domain of ARG, in a case of acute myeloid leukemia.	Arginine	29-32	ETS variant transcription factor 6	Homo sapiens	25-28
16310306-1	2006	We previously identified TEL/ARG as a novel fusion transcript consisting of the oligomerization domain of TEL and the kinase domain of ARG, in a case of acute myeloid leukemia.	Arginine	29-32	ETS variant transcription factor 6	Homo sapiens	106-109
16310306-1	2006	We previously identified TEL/ARG as a novel fusion transcript consisting of the oligomerization domain of TEL and the kinase domain of ARG, in a case of acute myeloid leukemia.	Arginine	135-138	ETS variant transcription factor 6	Homo sapiens	25-28
16310306-2	2006	We report here the existence of an alternatively spliced TEL/ARG transcript lacking part of a F-actin binding domain of ARG, and the phenotype of TEL/ARG expressing 293T cells.	Arginine	61-64	ETS variant transcription factor 6	Homo sapiens	57-60
16310306-2	2006	We report here the existence of an alternatively spliced TEL/ARG transcript lacking part of a F-actin binding domain of ARG, and the phenotype of TEL/ARG expressing 293T cells.	Arginine	120-123	ETS variant transcription factor 6	Homo sapiens	57-60
16310306-2	2006	We report here the existence of an alternatively spliced TEL/ARG transcript lacking part of a F-actin binding domain of ARG, and the phenotype of TEL/ARG expressing 293T cells.	Arginine	120-123	ETS variant transcription factor 6	Homo sapiens	57-60
16710051-5	2006	We conclude that mTOR/p70(s6k) signaling is essential to intestinal cell migration, is activated by ARG, involves both nuclear and cytoplasmic events, and may play a role in intestinal repair.	Arginine	100-103	mechanistic target of rapamycin kinase	Homo sapiens	17-21
17094395-0	2006	The p53 codon 72 arg/arg homozygous women in central Italy are at increased risk for HPV infections.	Arginine	17-20	tumor protein p53	Homo sapiens	4-7
17094395-0	2006	The p53 codon 72 arg/arg homozygous women in central Italy are at increased risk for HPV infections.	Arginine	21-24	tumor protein p53	Homo sapiens	4-7
17094395-1	2006	BACKGROUND: The oncoprotein E6 binds to and degrades the p53 tumor suppressor protein, with different efficacy depending on the p53 codon 72 (arg/pro) polymorphism.	Arginine	142-145	tumor protein p53	Homo sapiens	57-60
16781079-9	2006	In the absence of L-arginine, strong .O(2)(-) generation was observed from nNOS, and this was blocked by CBP-PIN in a dose-dependent manner.	Arginine	18-28	CREB binding protein	Homo sapiens	105-108
16781079-9	2006	In the absence of L-arginine, strong .O(2)(-) generation was observed from nNOS, and this was blocked by CBP-PIN in a dose-dependent manner.	Arginine	18-28	dynein light chain LC8-type 1	Homo sapiens	109-112
16730327-9	2006	Early expression of BAC1 and BAC2 is consistent with the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine.	Arginine	69-77	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	29-33
16616056-1	2006	BACKGROUND: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to L-citruline for the action at the endothelial nitric oxide synthase (eNOS), is considered an important atheroprotective factor.	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	125-158
16730327-10	2006	Increase of BAC2 transcript levels later in seedling development is consistent with roles in NO, polyamine or proline metabolism--processes involving arginine, citrulline and/or ornithine.	Arginine	150-158	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	12-16
16806914-3	2006	Molecular modeling (docking) studies showed that the tetrazole ring of these two analogues (9 and 13) was inserted deep into the secondary pocket of the human COX-2 binding site where it undergoes electrostatic interaction with Arg(513).	Arginine	228-231	prostaglandin-endoperoxide synthase 2	Homo sapiens	159-164
16616056-1	2006	BACKGROUND: Nitric oxide (NO) from the endothelium, produced by oxidation of l-arginine to L-citruline for the action at the endothelial nitric oxide synthase (eNOS), is considered an important atheroprotective factor.	Arginine	77-87	nitric oxide synthase 3	Homo sapiens	160-164
16616057-1	2006	BACKGROUND: Carboxypeptidase N is a plasma zinc metallocarboxypeptidase which is constitutively expressed in the liver and was identified as the enzyme responsible for inactivating bradykinin and kallidin by removing the C-terminal arginine.	Arginine	232-240	kininogen 1	Homo sapiens	181-191
16616057-2	2006	Because CPN can cleave the C-terminal arginine of C3a, C4a and C5a it is often referred to as anaphylatoxin inactivator.	Arginine	38-46	complement C5a receptor 1	Homo sapiens	63-66
17055289-5	2006	In TNF proteins, the cationic groups Lys preferred to be in helix while Arg preferred to be in strand regions while in Interleukins the Arg residues preferred to be in helix and Lys preferred to be in strand regions.	Arginine	72-75	tumor necrosis factor	Homo sapiens	3-6
17072234-8	2006	Responses to ACTH or GHRH-arginine tests may be normal for several years though an ACTH and/or GH deficiency has been demonstrated by an insulin tolerance test, which is considered as the gold standard.	Arginine	26-34	growth hormone releasing hormone	Homo sapiens	21-25
17055289-5	2006	In TNF proteins, the cationic groups Lys preferred to be in helix while Arg preferred to be in strand regions while in Interleukins the Arg residues preferred to be in helix and Lys preferred to be in strand regions.	Arginine	136-139	tumor necrosis factor	Homo sapiens	3-6
16741262-0	2006	Oral arginine attenuates the growth hormone response to resistance exercise.	Arginine	5-13	growth hormone 1	Homo sapiens	29-43
16977256-2	2006	The subsequent first phase insulin response (also termed acute insulin response or AIR) to intravenous glucose or arginine has been quantified in a variety of ways, from the mean serum insulin measured at multiple times after glucose injection to the mean value above baseline of serum insulin at 2 to 10 min.	Arginine	114-122	insulin	Homo sapiens	27-34
16977256-2	2006	The subsequent first phase insulin response (also termed acute insulin response or AIR) to intravenous glucose or arginine has been quantified in a variety of ways, from the mean serum insulin measured at multiple times after glucose injection to the mean value above baseline of serum insulin at 2 to 10 min.	Arginine	114-122	insulin	Homo sapiens	63-70
16977256-2	2006	The subsequent first phase insulin response (also termed acute insulin response or AIR) to intravenous glucose or arginine has been quantified in a variety of ways, from the mean serum insulin measured at multiple times after glucose injection to the mean value above baseline of serum insulin at 2 to 10 min.	Arginine	114-122	insulin	Homo sapiens	63-70
16977256-2	2006	The subsequent first phase insulin response (also termed acute insulin response or AIR) to intravenous glucose or arginine has been quantified in a variety of ways, from the mean serum insulin measured at multiple times after glucose injection to the mean value above baseline of serum insulin at 2 to 10 min.	Arginine	114-122	insulin	Homo sapiens	63-70
16879614-0	2006	Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.	Arginine	52-60	hyaluronan binding protein 4	Homo sapiens	0-7
16879614-5	2006	We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1.	Arginine	77-80	hyaluronan binding protein 4	Homo sapiens	14-21
16879614-5	2006	We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1.	Arginine	77-80	SERPINE1 mRNA binding protein 1	Homo sapiens	47-53
16879614-5	2006	We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1.	Arginine	169-177	hyaluronan binding protein 4	Homo sapiens	14-21
16879614-5	2006	We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1.	Arginine	169-177	SERPINE1 mRNA binding protein 1	Homo sapiens	47-53
16741262-1	2006	This study investigated the combined effect of resistance exercise and arginine ingestion on spontaneous growth hormone (GH) release.	Arginine	71-79	growth hormone 1	Homo sapiens	105-119
16741262-1	2006	This study investigated the combined effect of resistance exercise and arginine ingestion on spontaneous growth hormone (GH) release.	Arginine	71-79	growth hormone 1	Homo sapiens	121-123
16741262-9	2006	The GH secretory burst mass was larger, but not significantly, on the Arg, Ex, and Arg+Ex day than the placebo day.	Arginine	70-73	growth hormone 1	Homo sapiens	4-6
16741262-9	2006	The GH secretory burst mass was larger, but not significantly, on the Arg, Ex, and Arg+Ex day than the placebo day.	Arginine	83-86	growth hormone 1	Homo sapiens	4-6
16741262-10	2006	Endogenous GH production rate (Ex &gt; Arg+Ex &gt; Arg &gt; placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P &lt; 0.05) but there were no differences between the Ex and Arg+Ex day.	Arginine	39-42	growth hormone 1	Homo sapiens	11-13
16741262-10	2006	Endogenous GH production rate (Ex &gt; Arg+Ex &gt; Arg &gt; placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P &lt; 0.05) but there were no differences between the Ex and Arg+Ex day.	Arginine	51-54	growth hormone 1	Homo sapiens	11-13
16741262-10	2006	Endogenous GH production rate (Ex &gt; Arg+Ex &gt; Arg &gt; placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P &lt; 0.05) but there were no differences between the Ex and Arg+Ex day.	Arginine	51-54	growth hormone 1	Homo sapiens	11-13
16741262-10	2006	Endogenous GH production rate (Ex &gt; Arg+Ex &gt; Arg &gt; placebo) was greater on the Ex and Arg+Ex day than on the placebo day (P &lt; 0.05) but there were no differences between the Ex and Arg+Ex day.	Arginine	51-54	growth hormone 1	Homo sapiens	11-13
16741262-11	2006	Oral arginine alone (7 g) stimulated GH release, but a greater GH response was seen with exercise alone.	Arginine	5-13	growth hormone 1	Homo sapiens	37-39
16741262-12	2006	The combined effect of arginine before exercise attenuates the GH response.	Arginine	23-31	growth hormone 1	Homo sapiens	63-65
16717106-0	2006	L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	67-88
16907925-4	2006	We therefore investigated how arginine-specific gingipains (Rgps) affect the functions of SLPI, because Rgps are the major virulence factors in the vesicles and cleave a wide range of in-host proteins.	Arginine	30-38	secretory leukocyte peptidase inhibitor	Homo sapiens	90-94
16717106-2	2006	We have recently found that leukocyte-derived hypochlorous acid is able to react with the nitric-oxide synthase (NOS) substrate L-arginine to produce chlorinated L-arginine (cl-L-Arg).	Arginine	128-138	nitric oxide synthase 2	Homo sapiens	90-111
16717106-2	2006	We have recently found that leukocyte-derived hypochlorous acid is able to react with the nitric-oxide synthase (NOS) substrate L-arginine to produce chlorinated L-arginine (cl-L-Arg).	Arginine	162-172	nitric oxide synthase 2	Homo sapiens	90-111
16737969-8	2006	In ZO1-PDZ1, an Asp residue makes favorable interactions with both Tyr(-1) and Lys/Arg(-3).	Arginine	83-86	tight junction protein 1	Homo sapiens	3-11
16801455-1	2006	Reduced synthesis of nitric oxide (NO) contributes to the endothelial dysfunction and may be related to limited availability of L-arginine, the common substrate of constitutive nitric-oxide synthase (NOS) and cytosolic arginase I and mitochondrial arginase II.	Arginine	128-138	nitric oxide synthase 2	Homo sapiens	177-198
16801455-6	2006	When HUVECs were stimulated by thrombin in the presence of 100 microM L-arginine, NOS activity and NO release were similar in untreated and Nor-NOHA-treated cells.	Arginine	70-80	coagulation factor II, thrombin	Homo sapiens	31-39
16754677-3	2006	Here we have examined the role of arginine residues that the homology model locates in or close to the binding site of the GABA(C) receptor (Arg-104, Arg-170, Arg-158, and Arg-249) using mutagenesis and functional studies.	Arginine	34-42	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	123-139
16754677-3	2006	Here we have examined the role of arginine residues that the homology model locates in or close to the binding site of the GABA(C) receptor (Arg-104, Arg-170, Arg-158, and Arg-249) using mutagenesis and functional studies.	Arginine	141-144	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	123-139
16754677-3	2006	Here we have examined the role of arginine residues that the homology model locates in or close to the binding site of the GABA(C) receptor (Arg-104, Arg-170, Arg-158, and Arg-249) using mutagenesis and functional studies.	Arginine	150-153	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	123-139
16754677-3	2006	Here we have examined the role of arginine residues that the homology model locates in or close to the binding site of the GABA(C) receptor (Arg-104, Arg-170, Arg-158, and Arg-249) using mutagenesis and functional studies.	Arginine	150-153	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	123-139
16754677-3	2006	Here we have examined the role of arginine residues that the homology model locates in or close to the binding site of the GABA(C) receptor (Arg-104, Arg-170, Arg-158, and Arg-249) using mutagenesis and functional studies.	Arginine	150-153	gamma-aminobutyric acid type A receptor subunit rho3	Homo sapiens	123-139
17072025-3	2006	HCAs were also tested on the arginine-specific mono-ADP-ribosyltransferase A (MART-A), an enzyme involved in signal transduction and cytoskeletal realignment.	Arginine	29-37	septin 4	Homo sapiens	78-82
16962972-6	2006	Physiological analyses of wild-type AQP1 and a designed mutant in which two arginines of the gating loop are replaced by alanine provide experimental support for identifying a key component of the proposed mechanism.	Arginine	76-85	aquaporin 1 (Colton blood group)	Homo sapiens	36-40
16790440-4	2006	Our results show that the NH(2)-terminal third of NPS, in particular residues Phe-2, Arg-3, Asn-4, and Val-6, are necessary and sufficient for activation of NPSR.	Arginine	85-88	neuropeptide S receptor 1	Homo sapiens	157-161
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Arginine	23-31	Cbf2p	Saccharomyces cerevisiae S288C	76-81
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Arginine	23-31	Cbf2p	Saccharomyces cerevisiae S288C	131-136
16737969-9	2006	In contrast, Erbin-PDZ contains an Arg at the equivalent position, and this side chain cannot accommodate either Tyr(-1) or Lys/Arg(-3) but, instead, interacts favorably with Glu/Asp(-3).	Arginine	35-38	erbb2 interacting protein	Homo sapiens	13-22
16737969-9	2006	In contrast, Erbin-PDZ contains an Arg at the equivalent position, and this side chain cannot accommodate either Tyr(-1) or Lys/Arg(-3) but, instead, interacts favorably with Glu/Asp(-3).	Arginine	128-131	erbb2 interacting protein	Homo sapiens	13-22
16835507-3	2006	We evaluated the linkage of the polymorphic variants (Arg/Pro) on TP53 codon 72 with nasopharyngeal cancer development in a case-control study with 392 individuals from a northern Portuguese population, including 107 patients with nasopharyngeal carcinoma and 285 healthy controls.	Arginine	54-57	tumor protein p53	Homo sapiens	66-70
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	insulin	Homo sapiens	33-40
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	NADH:ubiquinone oxidoreductase subunit B9	Homo sapiens	42-45
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	insulin	Homo sapiens	58-65
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	insulin	Homo sapiens	58-65
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	NADH:ubiquinone oxidoreductase subunit B9	Homo sapiens	119-122
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	NADH:ubiquinone oxidoreductase subunit B9	Homo sapiens	119-122
16894475-2	2006	Here we report a novel monomeric insulin, B22 Glu des-B30 insulin, prepared from a single chain insulin precursor with B22 Arg mutated to Glu, which was expressed in Pichia pastoris and converted to B22 Glu des-B30 insulin by tryptic digestion.	Arginine	123-126	insulin	Homo sapiens	58-65
16790523-4	2006	The integrin receptor is near the Arg-Gly-Asp (RGD) recognition site on the integrin; an integrin-binding RGD peptide inhibits induction by resveratrol of ERK1/2- and p53-dependent apoptosis.	Arginine	34-37	mitogen-activated protein kinase 3	Homo sapiens	155-161
16790523-4	2006	The integrin receptor is near the Arg-Gly-Asp (RGD) recognition site on the integrin; an integrin-binding RGD peptide inhibits induction by resveratrol of ERK1/2- and p53-dependent apoptosis.	Arginine	34-37	tumor protein p53	Homo sapiens	167-170
16788846-6	2006	CONCLUSIONS: We were unable to demonstrate any association between the GST genotypes studied and the risk of ovarian cancer but the inheritance of a heterozygous Arg/Pro genotype of p53 increased the risk of ovarian cancer more than 2.5 times (OR = 2.571; 95% CI = 1.453-4.550).	Arginine	162-165	tumor protein p53	Homo sapiens	182-185
16849482-2	2006	In the present study, we show that altering specific Arg residues in the H chain of a human pathogenic beta2GPI-dependent aPL, IS4, has major effects on its ability to bind these clinically important Ags.	Arginine	53-56	IS4	Homo sapiens	127-130
16847311-6	2006	This unusual property relies on the existence of a second binding surface in the SAP SH2 domain, centered on arginine 78 of SAP, that binds directly to the FynT SH3 domain.	Arginine	109-117	SH2 domain containing 1A	Homo sapiens	81-84
16847311-6	2006	This unusual property relies on the existence of a second binding surface in the SAP SH2 domain, centered on arginine 78 of SAP, that binds directly to the FynT SH3 domain.	Arginine	109-117	SH2 domain containing 1A	Homo sapiens	124-127
16849482-4	2006	V(H) sequences were derived from IS4 by altering the number of Arg residues in CDR3.	Arginine	63-66	IS4	Homo sapiens	33-36
16579792-6	2006	The p53(F270A:6KR) chimaeric mutant (where 6KR refers to the simultaneous mutation of lysine residues at positions 370, 372, 373, 381, 382 and 386 to arginine) maintains the high-molecular-mass covalent adducts and is modified in an MDM2-dependent manner.	Arginine	150-158	tumor protein p53	Homo sapiens	4-7
17551466-14	2006	A point mutation in exon 3, codon 80 of the 17 beta-HSD3 gene, R80Q, caused by a single base substitution from CGG ( arginine) to CAG ( glutamine) was identified in both alleles of 24 individuals from 9 extended Arab families from Gaza, Jerusalem and Lod-Ramle.	Arginine	117-125	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	44-56
16764826-3	2006	In this study, we determined that the NO generated from l-arginine by ectopically overexpressed nNOS in HEK293 cells exerted an inhibitory effect against the activity of c-Jun N-terminal kinase (JNK), an important modulator of neuronal cell death and survival signaling pathways.	Arginine	56-66	mitogen-activated protein kinase 8	Homo sapiens	170-193
16764826-3	2006	In this study, we determined that the NO generated from l-arginine by ectopically overexpressed nNOS in HEK293 cells exerted an inhibitory effect against the activity of c-Jun N-terminal kinase (JNK), an important modulator of neuronal cell death and survival signaling pathways.	Arginine	56-66	mitogen-activated protein kinase 8	Homo sapiens	195-198
16864840-2	2006	Sequence analysis of EIF2B5 gene showed that the patient was a double heterozygote, with novel missense mutation CGA-->CAA in codon 269 of exon 6, resulting in the replacement of an arginine residue with glutamine.	Arginine	182-190	eukaryotic translation initiation factor 2B subunit epsilon	Homo sapiens	21-27
16819929-8	2006	The activity of the synthetic histatin 5 in which all of the Lys and Arg were substituted by Ala was at the same level as histatin 5.	Arginine	69-72	histatin 3	Homo sapiens	30-40
16675494-2	2006	NO bioavailability in aged skin may be decreased by an age-related upregulation of arginase, which reciprocally regulates the NO-synthase (NOS) substrate L-arginine (L-Arg).	Arginine	154-164	nitric oxide synthase 2	Homo sapiens	126-137
16675494-2	2006	NO bioavailability in aged skin may be decreased by an age-related upregulation of arginase, which reciprocally regulates the NO-synthase (NOS) substrate L-arginine (L-Arg).	Arginine	166-171	nitric oxide synthase 2	Homo sapiens	126-137
16788313-4	2006	After 20 min, 50 microl of 1 mmol/l (final concentration 0.24 mmol/l) chromogenic thrombin substrate CHG-Ala-Arg-pNA in 1.25 mol/l arginine, pH 8.7, is added.	Arginine	131-139	coagulation factor II, thrombin	Homo sapiens	82-90
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	65-68	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-7	2006	Alpha-thrombin readily activated factor V following cleavages at Arg(709), Arg(1018), and Arg(1545) and factor VIII following proteolysis at Arg(372), Arg(740), and Arg(1689).	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	6-14
16624813-11	2006	Beta-thrombin was found to cleave factor V at Arg(709) and factor VIII at Arg(740), albeit less efficiently than alpha-thrombin.	Arginine	46-49	coagulation factor II, thrombin	Homo sapiens	5-13
16624813-11	2006	Beta-thrombin was found to cleave factor V at Arg(709) and factor VIII at Arg(740), albeit less efficiently than alpha-thrombin.	Arginine	74-77	coagulation factor II, thrombin	Homo sapiens	5-13
16669787-8	2006	Mutation of the arginine, phenylalanine or valine residue within this peptide abolishes binding to SPAK/OSR1.	Arginine	16-24	serine/threonine kinase 39	Homo sapiens	99-103
16669787-8	2006	Mutation of the arginine, phenylalanine or valine residue within this peptide abolishes binding to SPAK/OSR1.	Arginine	16-24	odd-skipped related transcription factor 1	Homo sapiens	104-108
16819336-7	2006	PCR amplification followed by sequencing showed that all 3 were heterozygous for a CGG&gt;TGG mutation at codon 375 of the fibrinogen gamma-chain gene (FGG), corresponding to an Arg&gt;Trp substitution.	Arginine	178-181	fibrinogen gamma chain	Homo sapiens	123-145
16819336-7	2006	PCR amplification followed by sequencing showed that all 3 were heterozygous for a CGG&gt;TGG mutation at codon 375 of the fibrinogen gamma-chain gene (FGG), corresponding to an Arg&gt;Trp substitution.	Arginine	178-181	fibrinogen gamma chain	Homo sapiens	152-155
16723378-4	2006	Tandem MS analysis of insulin B-chain adducts confirmed attachment of MG at an arginine residue.	Arginine	79-87	insulin	Homo sapiens	22-29
16723378-10	2006	In conclusion, MG modifies insulin by attaching to internal arginine residue in beta-chain of insulin.	Arginine	60-68	insulin	Homo sapiens	27-34
16723378-10	2006	In conclusion, MG modifies insulin by attaching to internal arginine residue in beta-chain of insulin.	Arginine	60-68	insulin	Homo sapiens	94-101
16497732-0	2006	Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.	Arginine	23-31	nuclear factor kappa B subunit 1	Homo sapiens	61-82
16959686-4	2006	The concentration of the thrombin substrate (HD-CHG-Ala-Arg-pNA) was optimized, using final substrate concentrations of 0 to 5 mM, a final arginine concentration of 1.13 M, and samples of 10 mIU/mL purified thrombin in 7% human albumin or pooled normal citrated plasma without and with EDTA.	Arginine	139-147	coagulation factor II, thrombin	Homo sapiens	25-33
16839343-4	2006	In apparent contrast to these observations, a second LRP-binding region has been identified within A2 domain region Arg(484)-Phe(509) of FVIII heavy chain.	Arginine	116-119	LDL receptor related protein 1	Homo sapiens	53-56
16839343-9	2006	Competition studies employing a recombinant antibody fragment demonstrated that region Arg(484)-Phe(509) mediates the enhanced LRP binding after thrombin cleavage.	Arginine	87-90	LDL receptor related protein 1	Homo sapiens	127-130
16839343-9	2006	Competition studies employing a recombinant antibody fragment demonstrated that region Arg(484)-Phe(509) mediates the enhanced LRP binding after thrombin cleavage.	Arginine	87-90	coagulation factor II, thrombin	Homo sapiens	145-153
16799062-9	2006	RESULTS: Treatment of hRPE cells with Arg-Gln decreased VEGF levels in a dose-dependent manner.	Arginine	38-41	vascular endothelial growth factor A	Homo sapiens	56-60
16497732-1	2006	Coactivator-associated arginine methyltransferase-1 (CARM1) is known to enhance transcriptional activation by nuclear receptors through interactions with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17).	Arginine	23-31	MYB binding protein 1a	Homo sapiens	171-175
16497732-1	2006	Coactivator-associated arginine methyltransferase-1 (CARM1) is known to enhance transcriptional activation by nuclear receptors through interactions with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17).	Arginine	23-31	CREB binding protein	Homo sapiens	235-238
16864073-6	2006	RESULTS: We identified a T to A transition mutation at position 4,603 in exon 40, resulting in the substitution of arginine for a tryptophan at amino acid residue 1,535 (W1535R) in the regulatory domain of 220-kD ankyrin-B, which is a highly conserved domain shared by different species.	Arginine	115-123	ankyrin 2	Homo sapiens	213-222
16786124-1	2006	The TP53 polymorphism occurs at codon 72 of exon 4 with two alleles encoding either arginine or proline.	Arginine	84-92	tumor protein p53	Homo sapiens	4-8
16734667-6	2006	Multimeric presentation of the Arg-based signal from Kir6.2 on Pmp2p results in forward transport, which requires 14-3-3 proteins encoded in yeast by BMH1 and BMH2 in two isoforms.	Arginine	31-34	14-3-3 family protein BMH1	Saccharomyces cerevisiae S288C	150-154
17007382-6	2006	The threshold shift of CAP in group 8 was 42.5 dB, and it decreased in group 9 by L-arginine, on this foundation nNOS inhibitor was added, increased threshold shift of CAP was 6.5 dB, similar with group 8.	Arginine	82-92	nitric oxide synthase, brain	Cavia porcellus	113-117
17007382-9	2006	CONCLUSIONS: The NO-cGMP pathway could regulate cochlear sensitivity; L-arginine may improve the function of Corti"s organ via nNOS, and they indicate an important role of supporting cells in the modulation of cochlear function.	Arginine	70-80	nitric oxide synthase, brain	Cavia porcellus	127-131
16765486-1	2006	Inducible nitric oxide synthase (iNOS) is one of three NOS isoforms generating nitric oxide (NO) by the conversion of l-arginine to l-citrulline.	Arginine	118-128	nitric oxide synthase 2	Homo sapiens	0-31
16765486-1	2006	Inducible nitric oxide synthase (iNOS) is one of three NOS isoforms generating nitric oxide (NO) by the conversion of l-arginine to l-citrulline.	Arginine	118-128	nitric oxide synthase 2	Homo sapiens	33-37
16712773-0	2006	Identification of critical arginine residues in the functioning of Rubisco activase.	Arginine	27-35	ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic	Nicotiana tabacum	67-83
16815914-2	2006	ABCG2 variants harboring a mutation at arginine 482 have been cloned from several drug-resistant cell lines, and these variants differ in their substrate transport phenotype.	Arginine	39-47	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-5
16815914-3	2006	In this study, we changed the wild-type arginine 482 in human ABCG2 to each one of the 19 other standard amino acids and expressed each one transiently in HeLa cells.	Arginine	40-48	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	62-67
16794538-10	2006	CONCLUSION: The results suggest that upregulation of arginase activity by Th2 cytokines during xenograft rejection limits the bioavailability of L-arginine for the inducible NO synthase and thus attenuates generation of NO by the graft-infiltrating macrophages.	Arginine	145-155	nitric oxide synthase 2	Rattus norvegicus	164-185
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	227-235	ADP-ribosyltransferase 1	Homo sapiens	0-4
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	227-235	ADP-ribosyltransferase 1	Homo sapiens	76-80
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	227-235	ADP-ribosyltransferase 1	Homo sapiens	76-80
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	273-281	ADP-ribosyltransferase 1	Homo sapiens	0-4
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	273-281	ADP-ribosyltransferase 1	Homo sapiens	76-80
16627471-8	2006	ART1 synthesized in Escherichia coli, glycosylphosphatidylinositol-anchored ART1 released with phosphatidylinositol-specific phospholipase C from transfected NMU cells, or ART1 expressed endogenously on C2C12 myotubes modified arginine 14 on HNP-1 with a secondary site on arginine 24.	Arginine	273-281	ADP-ribosyltransferase 1	Homo sapiens	76-80
16778112-4	2006	EXPERIMENTAL DESIGN: We developed a new targeting vector by conjugating the chelator 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid to Arg(1) of substance P, generating a radiopharmaceutical with a molecular weight of 1,806 Da and an IC(50) of 0.88 +/- 0.34 nmol/L.	Arginine	157-160	tachykinin precursor 1	Homo sapiens	167-178
16712773-1	2006	Rubisco activase is a member of the AAA(+) family in which arginines located in the Box VII and Sensor 2 domains are a recurrent feature and typically contribute to ATP-binding/hydrolysis or an inter-subunit interface.	Arginine	59-68	ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic	Nicotiana tabacum	0-16
16713055-4	2006	We now report that a competent NOS2 with l-arginine can, like NOS1, oxidize EtOH to CH3*CHOH.	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	31-35
16713055-6	2006	These observations suggest that NOS2 can behave similarly to cytochrome P-450 in the catalysis of acetaldehyde formation from ethanol via the generation of alpha-hydroxyethyl radical when L-arginine is present.	Arginine	188-198	nitric oxide synthase 2	Homo sapiens	32-36
16713055-6	2006	These observations suggest that NOS2 can behave similarly to cytochrome P-450 in the catalysis of acetaldehyde formation from ethanol via the generation of alpha-hydroxyethyl radical when L-arginine is present.	Arginine	188-198	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-77
16845912-2	2006	L-arginine transport mediated by the isozymes of type-2 cationic amino acid transporter (including CAT-2 and CAT-2B) has been reported to play a crucial role in regulating iNOS activity.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	172-176
16380201-2	2006	The expression of the argininosuccinate synthetase gene (ASS), the limiting enzyme of arginine synthesis, was previously shown to be rapidly induced by a short-term (4 h) exposure to IL-1beta in Caco-2 cells [Biochimie, 2005, 403-409].	Arginine	86-94	interleukin 1 beta	Homo sapiens	183-191
16380201-5	2006	Indeed, the inhibiting effect of IL-1beta was totally blocked in the presence of l-NMMA, an inhibitor of the inducible nitric oxide synthase, or by culturing the cells in an arginine-deprived medium.	Arginine	174-182	interleukin 1 beta	Homo sapiens	33-41
16267670-2	2006	In the L-arginine-NO pathway, NO synthase (NOS) converts L-arginine to NO and L-citrulline.	Arginine	7-17	nitric oxide synthase 2	Homo sapiens	30-41
16787198-10	2006	L-arginine inhibits platelet aggregation both in vitro and in vivo, while L-NMMA (NG-monomethyl-L-arginine), an endogenous L-arginine analogue and inhibitor of NO synthase (NOS), increases platelet activation and adhesion.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	160-171
16728545-14	2006	The ITT (or the GHRH-arginine test) is therefore reliable in establishing the diagnosis of GHD in patients treated for acromegaly by surgery and radiotherapy.	Arginine	21-29	growth hormone releasing hormone	Homo sapiens	16-20
16595170-6	2006	In contrast, the Arg(3.50) to Gly mutation found in hamster GPR33 inactivates the receptor and may have contributed to pseudogenization of this gene in this species.	Arginine	17-20	G protein-coupled receptor 33	Homo sapiens	60-65
16703566-1	2006	In murine macrophages, as a result of arginine catabolism during activation, citruline is produced under the effect of IFN-gamma and LPS, and ornithine and polyamines by IL-4 and IL-10.	Arginine	38-46	interleukin 10	Mus musculus	179-184
16267670-2	2006	In the L-arginine-NO pathway, NO synthase (NOS) converts L-arginine to NO and L-citrulline.	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	30-41
16484312-7	2006	CONCLUSIONS: Control of the catalytic activity of iNOS in adhesion fibroblasts may be because of subsaturating amounts of L-Arg and H4B which allow iNOS to generate a combination of reactive oxygen species in addition to NO, thereby influencing NO bioavailability and function.	Arginine	122-127	nitric oxide synthase 2	Rattus norvegicus	50-54
16484312-7	2006	CONCLUSIONS: Control of the catalytic activity of iNOS in adhesion fibroblasts may be because of subsaturating amounts of L-Arg and H4B which allow iNOS to generate a combination of reactive oxygen species in addition to NO, thereby influencing NO bioavailability and function.	Arginine	122-127	nitric oxide synthase 2	Rattus norvegicus	148-152
16432543-10	2006	A difference in high-density lipoprotein cholesterol (HDL-c) levels was present between carriers and non-carriers of an Arg allele, 1.21 vs 1.28 mmol/l, respectively (P=0.04), but no differences in obesity, insulin resistance and other lipid parameters were found.	Arginine	120-123	insulin	Homo sapiens	207-214
16702303-10	2006	Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats.	Arginine	65-68	angiotensin I converting enzyme	Rattus norvegicus	5-8
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	aryl hydrocarbon receptor nuclear translocator like 2	Homo sapiens	139-144
16685415-6	2006	These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation.	Arginine	36-39	aryl hydrocarbon receptor nuclear translocator like 2	Homo sapiens	119-124
16537686-12	2006	With the assay used, changes in the GH peak response to GHRH+ARG were accompanied by changes in the IGF-I SDS, metabolic profile, and carotid IMT.	Arginine	61-64	insulin like growth factor 1	Homo sapiens	100-105
16840832-3	2006	The GHRH+arginine (GHRH+ARG) test is likely to be the overall test of choice in clinical practice to differentiate GH deficiency (GHD) patients.	Arginine	9-17	growth hormone releasing hormone	Homo sapiens	19-23
16840832-3	2006	The GHRH+arginine (GHRH+ARG) test is likely to be the overall test of choice in clinical practice to differentiate GH deficiency (GHD) patients.	Arginine	24-27	growth hormone releasing hormone	Homo sapiens	4-8
16702303-10	2006	Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats.	Arginine	77-80	angiotensin I converting enzyme	Rattus norvegicus	5-8
16702303-10	2006	Some ACE-inhibitory peptides obtained from this hydrolysate (Tyr-Arg-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, Arg-Ala-Asp-His-Pro-Phe-Leu, and Ile-Val-Phe) also showed antihypertensive activity in these rats.	Arginine	77-80	angiotensin I converting enzyme	Rattus norvegicus	5-8
16774477-4	2006	GH-secretory capacity was assessed with a GHRH-arginine stimulation test and GHD and GHI were defined as peak GH&lt;6 or &lt;or=12 ng/mL (5th and 10th percentiles of healthy control subjects, respectively).	Arginine	47-55	growth hormone releasing hormone	Homo sapiens	42-46
16828040-5	2006	Moreover, mutation of a conserved glycine residue into an arginine residue in FXYD2 has been linked to cases of human hypomagnesemia indicating that dysregulation of Na,K-ATPase by FXYD proteins may be implicated in pathophysiological states.	Arginine	58-66	FXYD domain containing ion transport regulator 2	Homo sapiens	78-83
16631200-2	2006	BACKGROUND: Therapeutic use of supplemental arginine has been proposed as a safe and efficacious method to produce NO from nitric oxide synthase (NOS) and to produce proline and polyamines from arginase to improve wound healing.	Arginine	44-52	nitric oxide synthase 2	Sus scrofa	123-144
16631200-3	2006	Although NO appears to be necessary to promote wound healing, the preferential metabolism of arginine to NO via NOS 2 may be detrimental if maintained beyond the initial days of healing.	Arginine	93-101	nitric oxide synthase 2	Sus scrofa	112-117
16631200-17	2006	CONCLUSION: Although NO appears to be necessary for granulation tissue formation, early supplemental arginine may disturb the reciprocal regulation of NOS 2 and arginase, leading to the preferential metabolism of arginine to excess NO rather than ornithine, with consequent reductions in angiogenesis and granulation tissue formation.	Arginine	101-109	nitric oxide synthase 2	Sus scrofa	151-156
16699006-0	2006	Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation.	Arginine	81-89	EBNA-1	Human gammaherpesvirus 4	18-23
16699006-2	2006	A Gly-Arg-rich region between amino acids 325 and 376 is required for both the segregation and transcriptional activation functions of EBNA1.	Arginine	6-9	EBNA-1	Human gammaherpesvirus 4	135-140
16699006-6	2006	Multiple arginines in the 325-376 region were methylated in vitro by PRMT1 and PRMT5, as was an N-terminal Gly-Arg-rich region between amino acids 41 and 50.	Arginine	9-18	protein arginine methyltransferase 5	Homo sapiens	79-84
16699006-9	2006	The results indicate that EBNA1 function is influenced by both serine phosphorylation and arginine methylation.	Arginine	90-98	EBNA-1	Human gammaherpesvirus 4	26-31
16410053-0	2006	In hepatocytes the regulation of NOS-2 activity at physiological L-arginine levels suggests a close link to the urea cycle.	Arginine	65-75	nitric oxide synthase 2	Rattus norvegicus	33-38
16410053-2	2006	As they compete for the same substrate, L-arginine, an interdependence of NOS-2 and arginase-1 has been repeatedly observed in cells where arginase-1 is cytokine-inducible.	Arginine	40-50	nitric oxide synthase 2	Rattus norvegicus	74-79
16410053-5	2006	We find that both, cytokine-induced NOS-2 and arginase activities strongly depend on extracellular L-arginine concentrations.	Arginine	99-109	nitric oxide synthase 2	Rattus norvegicus	36-41
16410053-11	2006	These data stress the hypothesis of a metabolon-like organization of the urea cycle together with NOS-2 in hepatocytes as excess L-ornithine will be metabolized to l-arginine and thereby increases NO production.	Arginine	164-174	nitric oxide synthase 2	Rattus norvegicus	98-103
16729222-1	2006	PURPOSE: Substance P (SP; NH3(+)-Arg(+)-Pro-Lys(+)-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) belongs to a group of neurokinins that are widely distributed in the central nervous system and peripheral nervous system.	Arginine	29-36	tachykinin precursor 1	Homo sapiens	9-20
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Arginine	82-90	Rho guanine nucleotide exchange factor 7	Homo sapiens	36-43
16650388-1	2006	The enzyme nitric oxide synthase (NOS) which is necessary for the production of nitric oxide from L-arginine exists in three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	11-32
16650388-1	2006	The enzyme nitric oxide synthase (NOS) which is necessary for the production of nitric oxide from L-arginine exists in three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	184-197
16650388-1	2006	The enzyme nitric oxide synthase (NOS) which is necessary for the production of nitric oxide from L-arginine exists in three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	199-203
16551627-1	2006	The Tat (twin-arginine translocation) system of Escherichia coli serves to translocate folded proteins across the cytoplasmic membrane.	Arginine	14-22	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	4-7
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Arginine	76-79	toll-like receptor 4	Mus musculus	149-152
16581846-3	2006	The results reveal three major contributions to the overall free-energy barrier for proton transport in AQP1: 1), the bipolar field, 2), the electrostatic repulsion due to the Arg-195 residue, and 3), the dehydration penalty due to the narrow channel pore.	Arginine	176-179	aquaporin 1 (Colton blood group)	Homo sapiens	104-108
16517159-3	2006	The aryl P1-moiety mimicking the arginine part of the d-Phe-Pro-Arg derived thrombin inhibitors turned out to be a key component for in vitro potency and in vivo activity.	Arginine	33-41	coagulation factor II	Rattus norvegicus	76-84
16670299-2	2006	Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline.	Arginine	59-67	negative elongation factor complex member C/D, Th1l	Mus musculus	0-3
16670299-2	2006	Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline.	Arginine	145-153	negative elongation factor complex member C/D, Th1l	Mus musculus	0-3
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Arginine	76-79	toll-like receptor 4	Mus musculus	157-161
16522628-0	2006	Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity.	Arginine	23-31	transglutaminase 2	Homo sapiens	59-77
16611332-5	2006	Glucose and arginine administered through the hepatic artery, but not through the portal vein, induced insulin release from the intraportally implanted islets.	Arginine	12-20	insulin	Homo sapiens	103-110
16643232-10	2006	Platonin also significantly inhibited up-regulation of CAT-2 and CAT-2B expression as well as L-arginine transport in LPS-stimulated murine macrophages in a dose-dependent manner.	Arginine	94-104	toll-like receptor 4	Mus musculus	118-121
16643232-12	2006	CONCLUSIONS: Platonin attenuates NO production and L-arginine transport in LPS-stimulated murine macrophages possibly through inhibiting iNOS, CAT-2, and CAT-2B expression.	Arginine	51-61	toll-like receptor 4	Mus musculus	75-78
16624253-3	2006	Earlier, we had shown that four arginine-framed tripeptide (AFT) signals in CFTR participate in the quality control.	Arginine	32-40	CF transmembrane conductance regulator	Homo sapiens	76-80
16391015-4	2006	Sequencing of PANE1 alleles in mHAg-positive and mHAg-negative cells demonstrates that differential T-cell recognition is due to a single nucleotide polymorphism within the variant exon that replaces an arginine codon with a translation termination codon.	Arginine	203-211	centromere protein M	Homo sapiens	14-19
17127468-4	2006	Effect of the protein hydrolysates on the CaM structure was greater with the fraction that contained higher contents of arginine and lysine when compared with the fraction with lower levels of these two amino acids.	Arginine	120-128	calmodulin 1	Homo sapiens	42-45
16622417-4	2006	Here, we show that PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin, and that the arginine residues in the PLD-PX are vital for this GAP function.	Arginine	177-185	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	202-205
16155195-0	2006	The phenotypic spectrum in patients with arginine to cysteine mutations in the COL2A1 gene.	Arginine	41-49	collagen type II alpha 1 chain	Homo sapiens	79-85
16155195-3	2006	OBJECTIVE: To investigate in more detail the phenotype resulting from arginine to cysteine mutations in the COL2A1 gene.	Arginine	70-78	collagen type II alpha 1 chain	Homo sapiens	108-114
16155195-4	2006	METHODS: The clinical and radiographic phenotype of all patients in whom an arginine to cysteine mutation in the COL2A1 gene was identified in our laboratory, was studied and correlated with the abnormal genotype.	Arginine	76-84	collagen type II alpha 1 chain	Homo sapiens	113-119
16155195-12	2006	CONCLUSIONS: Arginine to cysteine mutations are rather infrequent COL2A1 mutations which cause a spectrum of phenotypes including classic SEDC and Stickler dysplasia, but also some unusual entities that have not yet been recognised and described as type II collagenopathies.	Arginine	13-21	collagen type II alpha 1 chain	Homo sapiens	66-72
16155195-12	2006	CONCLUSIONS: Arginine to cysteine mutations are rather infrequent COL2A1 mutations which cause a spectrum of phenotypes including classic SEDC and Stickler dysplasia, but also some unusual entities that have not yet been recognised and described as type II collagenopathies.	Arginine	13-21	collagen type II alpha 1 chain	Homo sapiens	138-142
16503403-2	2006	The soluble factor lysophosphatidic acid (LPA) acts through Rho GTPase and its effector Rho kinase (ROCK) to enhance alpha5beta1 integrin-mediated cell spreading on the Arg-Gly-Asp (RGD) cell-binding domain of FN.	Arginine	169-172	fibronectin 1	Homo sapiens	210-212
16644693-7	2006	On the other hand, acute insulin response to arginine only showed correlation with the islet mass and not with donor age.	Arginine	45-53	insulin	Homo sapiens	25-32
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	66-69	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	tumor protein p53	Homo sapiens	47-50
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	tumor protein p53	Homo sapiens	47-50
16622417-4	2006	Here, we show that PLD functions as a GTPase activating protein (GAP) through its phox homology domain (PX), which directly activates the GTPase domain of dynamin, and that the arginine residues in the PLD-PX are vital for this GAP function.	Arginine	177-185	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	19-22
16698551-1	2006	Dimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS.	Arginine	8-16	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	41-45
16597825-4	2006	For example, effective inhibition of aggregation of 0.5 mM insulin required arginine concentrations of &gt; or =100 mM.	Arginine	76-84	insulin	Homo sapiens	59-66
16698551-1	2006	Dimethylarginine dimethylaminohydrolase (DDAH) is involved in the regulation of nitric oxide synthase (NOS) by metabolizing the free endogenous arginine derivatives N(omega)-methyl-L-arginine (MMA) and N(omega),N(omega)-dimethyl-L-arginine (ADMA), which are competitive inhibitors of NOS.	Arginine	8-16	nitric oxide synthase 2	Homo sapiens	80-101
16761419-4	2006	RESULTS: The frequencies of p53 Arg homozygosity in cervical squamous cancer, cervical adenocarcinoma and CIN (II - III) were 58.020%, 55.55% and 59.09% respectively, greater than those of p53 Arg/Pro heterozygosity (30.86%, 27.78%, 21.59%) and those of p53 Pro homozygosity (11.12%, 16.67%, 19.32%).	Arginine	32-35	tumor protein p53	Homo sapiens	28-31
16761419-9	2006	The frequency of p53 Arg homozygosity in HRHPV E6-positive cervical squamous cancers (64.06%) was greater than in HRHPV E6-negative cervical squamous cancers (35.29%) and in HRHPV E6-positive normal samples (33.33%).	Arginine	21-24	tumor protein p53	Homo sapiens	17-20
16698551-3	2006	The structure of DDAH-1 consists of a propeller-like fold similar to other arginine-modifying enzymes and a flexible loop, which adopts different conformations and acts as a lid at the entrance of the active site.	Arginine	75-83	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	17-23
16761419-4	2006	RESULTS: The frequencies of p53 Arg homozygosity in cervical squamous cancer, cervical adenocarcinoma and CIN (II - III) were 58.020%, 55.55% and 59.09% respectively, greater than those of p53 Arg/Pro heterozygosity (30.86%, 27.78%, 21.59%) and those of p53 Pro homozygosity (11.12%, 16.67%, 19.32%).	Arginine	193-196	tumor protein p53	Homo sapiens	28-31
16761419-5	2006	The normal cervical samples also showed less frequency of p53 Arg homozygosity (23.33%) than cervical squamous cancer.	Arginine	62-65	tumor protein p53	Homo sapiens	58-61
16599534-1	2006	The conformers of gaseous bradykinin, BK, (Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) and its protonated forms, [BK + H](+), [BK + 2H](2+), and [BK + 3H](3+), were examined theoretically using a combination of the Merck molecular force field, Hartree-Fock, and density functional theory.	Arginine	99-102	kininogen 1	Homo sapiens	26-36
16492668-0	2006	Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.	Arginine	11-19	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-154
16492668-7	2006	Methylation of arginine residues by protein-arginine methyltransferase 1 did not influence the RNA-binding activity, the translation inhibitory function, or the cellular localization of hnRNP K but reduced the interaction of hnRNP K with the tyrosine kinase c-Src.	Arginine	15-23	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	258-263
16764026-0	2006	[Blood levels of true insulin and immunoreactive insulin in evaluating beta-cell function with arginine stimulation test].	Arginine	95-103	insulin	Homo sapiens	49-56
16764026-8	2006	After arginine stimulation T2DM subjects mainly presented insulin resistance and decreased insulin secretion.	Arginine	6-14	insulin	Homo sapiens	58-65
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Arginine	159-167	uncharacterized protein	Drosophila melanogaster	87-90
16487488-0	2006	FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues.	Arginine	28-36	protein arginine methyltransferase 9	Homo sapiens	7-12
16584176-0	2006	Interaction between mitochondrial CYP27B1 and adrenodoxin: role of arginine 458 of mouse CYP27B1.	Arginine	67-75	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	89-96
16549969-2	2006	DESIGN: We investigated GH responses to growth hormone releasing hormone (GHRH) + arginine stimulation testing in HIV-infected subjects with fat redistribution, comparing HIV-infected males (n = 139) and females (n = 25) to non HIV-infected male (n = 25) and female (n = 26) control subjects similar in age, body mass index and race.	Arginine	82-90	growth hormone 1	Homo sapiens	24-26
16549969-4	2006	RESULTS: HIV-infected women had significantly higher peak GH in response to GHRH + arginine (36.4 +/- 7.3 versus 18.9 +/- 2.0 ng/ml; P = 0.003) and GH area under curve (AUC) (2679 +/- 593 versus 1284 +/- 133 (mg-min)/dl, P &lt; 0.001) compared to HIV-infected men.	Arginine	83-91	growth hormone 1	Homo sapiens	58-60
16549969-5	2006	Among men, a cutoff of 7.5 ng/ml for peak GH response on the GHRH + arginine test achieved good specificity and sensitivity and optimally separated the HIV and control groups (e.g., the failure rates were 37% versus 8%; P = 0.004, respectively).	Arginine	68-76	growth hormone 1	Homo sapiens	42-44
16549969-8	2006	In stepwise regression modeling waist-to-hip ratio was most significantly related to peak GH in response to GHRH + arginine in HIV-infected men.	Arginine	115-123	growth hormone 1	Homo sapiens	90-92
16257923-0	2006	Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel.	Arginine	78-86	nitric oxide synthase 2	Rattus norvegicus	62-66
16585403-2	2006	A functional eNOS oxidizes its substrate L-arginine to L-citrulline and NO*.	Arginine	41-51	nitric oxide synthase 3	Homo sapiens	13-17
16585403-3	2006	This normal function of eNOS requires dimerization of the enzyme, the presence of the substrate L-arginine, and the essential cofactor (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4), one of the most potent naturally occurring reducing agents.	Arginine	96-106	nitric oxide synthase 3	Homo sapiens	24-28
16257923-7	2006	iNOS was significantly increased by arginine but not by glutamine following gut I/R and was associated with increased MPO activity and mucosal injury.	Arginine	36-44	nitric oxide synthase 2	Rattus norvegicus	0-4
16257923-9	2006	The PPAR-gamma inhibitor G9662 abrogated the protective effects of glutamine, whereas the iNOS inhibitor 1400W attenuated the injurious effects of arginine.	Arginine	147-155	nitric oxide synthase 2	Rattus norvegicus	90-94
16641035-0	2006	Changes in pulmonary arteriole protein kinase calpha expression associated with supplemental L-arginine in broilers during cool temperature exposure.	Arginine	93-103	protein kinase C alpha	Homo sapiens	31-52
16389543-1	2006	Argatroban is a direct, selective and reversible active site thrombin inhibitor derived from L-arginine.	Arginine	93-103	coagulation factor II, thrombin	Homo sapiens	61-69
16708116-8	2006	Fifty microliters 2.5 M arginine stops coagulation, and 50 microL 0.77 mM HD-CHG-Ala-Arg-pNA in 2.3 M arginine starts the thrombin detection.	Arginine	102-110	coagulation factor II, thrombin	Homo sapiens	122-130
16708116-14	2006	Arginine added to blood or to plasma inhibits thrombin generation; the inhibitory concentration 50% (IC 50) is approximately 15 mM plasma concentration.	Arginine	0-8	coagulation factor II, thrombin	Homo sapiens	46-54
16600160-4	2006	Emerging evidence demonstrates that L-arginine is not only converted to NO via eNOS, but also metabolized to urea and l-ornithine via arginase in endothelial cells.	Arginine	36-46	nitric oxide synthase 3	Homo sapiens	79-83
16600160-5	2006	Hence, arginase competes with eNOS for the substrate L-arginine, resulting in deceased NO production.	Arginine	53-63	nitric oxide synthase 3	Homo sapiens	30-34
16437390-1	2006	Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS).	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	147-158
16332251-1	2006	We have previously shown that activation of PKC (protein kinase C) results in internalization of hCAT-1 [human CAT-1 (cationic amino acid transporter 1)] and a decrease in arginine transport [Rotmann, Strand, Martine and Closs (2004) J. Biol.	Arginine	172-180	proline rich transmembrane protein 2	Homo sapiens	44-47
16332251-1	2006	We have previously shown that activation of PKC (protein kinase C) results in internalization of hCAT-1 [human CAT-1 (cationic amino acid transporter 1)] and a decrease in arginine transport [Rotmann, Strand, Martine and Closs (2004) J. Biol.	Arginine	172-180	proline rich transmembrane protein 2	Homo sapiens	49-65
16332251-4	2006	However, others found increased transport rates for arginine in response to PKC activation, suggesting a differential effect of PKC on different CAT isoforms.	Arginine	52-60	proline rich transmembrane protein 2	Homo sapiens	76-79
16332251-4	2006	However, others found increased transport rates for arginine in response to PKC activation, suggesting a differential effect of PKC on different CAT isoforms.	Arginine	52-60	proline rich transmembrane protein 2	Homo sapiens	128-131
16332251-6	2006	In Xenopus laevis oocytes and human U373MG glioblastoma cells, hCAT-3-mediated L-arginine transport was significantly reduced upon treatment with compounds that activate classical PKC.	Arginine	79-89	proline rich transmembrane protein 2	Homo sapiens	180-183
16641035-1	2006	The present study was conducted to examine the effect of supplemental L-arginine on pulmonary arteriole protein kinase Calpha (PKCalpha) expression in broilers exposed to cool temperature, to investigate further the molecular mechanisms of supplemental L-arginine on modulating pulmonary vascular functions in hypertensive broilers.	Arginine	70-80	protein kinase C alpha	Homo sapiens	104-125
16641035-1	2006	The present study was conducted to examine the effect of supplemental L-arginine on pulmonary arteriole protein kinase Calpha (PKCalpha) expression in broilers exposed to cool temperature, to investigate further the molecular mechanisms of supplemental L-arginine on modulating pulmonary vascular functions in hypertensive broilers.	Arginine	70-80	protein kinase C alpha	Homo sapiens	127-135
16641035-4	2006	Birds fed additional L-arginine had increased plasma NO and decreased PKCalpha protein expression in pulmonary arterioles; NO production was negatively correlated with PKCalpha expression.	Arginine	21-31	protein kinase C alpha	Homo sapiens	70-78
16641035-4	2006	Birds fed additional L-arginine had increased plasma NO and decreased PKCalpha protein expression in pulmonary arterioles; NO production was negatively correlated with PKCalpha expression.	Arginine	21-31	protein kinase C alpha	Homo sapiens	168-176
16641035-5	2006	These results demonstrated that supplemental L-arginine diminished PKCalpha expression in birds exposed to cool temperature.	Arginine	45-55	protein kinase C alpha	Homo sapiens	67-75
16618617-8	2006	Mutation analysis revealed a heterozygous T&gt;C missense mutation in exon 1 of the EDNRB gene, that substitutes the highly conserved cysteine-90 residue in the extracellular domain of the G protein-coupled receptor with an arginine residue (C90R).	Arginine	224-232	endothelin receptor type B	Homo sapiens	84-89
16605112-3	2006	AAG to AGT transversion at codon 249 of the P53 gene arg-ser (249ser) has been identified as a hotspot, reflecting DNA damage caused by aflatoxin B1 metabolites in HCC.	Arginine	53-56	tumor protein p53	Homo sapiens	44-47
16499995-11	2006	Somatic TP53 mutations were found in 62 out of 240 NSCLC patients (26%), more frequently in Pro carriers (31%) than in Arg homozygotes (20%, p = 0.06).	Arginine	119-122	tumor protein p53	Homo sapiens	8-12
16623709-2	2006	Among the RFamide peptide groups, PQRFamide peptides, such as neuropeptide FF (NPFF) and neuropeptide AF (NPAF), share a common C-terminal Pro-Gln-Arg-Phe-NH(2) motif.	Arginine	147-150	neuropeptide FF-amide peptide precursor	Homo sapiens	62-77
16623709-2	2006	Among the RFamide peptide groups, PQRFamide peptides, such as neuropeptide FF (NPFF) and neuropeptide AF (NPAF), share a common C-terminal Pro-Gln-Arg-Phe-NH(2) motif.	Arginine	147-150	neuropeptide FF-amide peptide precursor	Homo sapiens	79-83
16679980-1	2006	PURPOSE: Oral L-arginine supplementation has been shown to improve treadmill time to exhaustion and resting insulin sensitivity in individuals with peripheral vascular disease and type 2 diabetes, respectively.	Arginine	14-24	insulin	Homo sapiens	108-115
16009421-1	2006	Nitric oxide is produced enzymatically by the nitric oxide synthase (NOS), which converts L-arginine in the presence of oxygen to L-citrulline and NO.	Arginine	90-100	nitric oxide synthase 2	Homo sapiens	46-67
16263169-5	2006	Real-time PCR analysis of hBD-1 in human colon cells, HCT-116, revealed upregulation after treatment with arginine, isoleucine, and bovine serum albumin (BSA).	Arginine	106-114	defensin beta 1	Homo sapiens	26-31
16009421-2	2006	Moreover, it has been reported that asymmetric dimethylarginine (ADMA) acts as is an endogenous inhibitor of endothelial NOS (eNOS) by competing with the enzyme for L-arginine.	Arginine	165-175	nitric oxide synthase 3	Homo sapiens	109-124
16009421-2	2006	Moreover, it has been reported that asymmetric dimethylarginine (ADMA) acts as is an endogenous inhibitor of endothelial NOS (eNOS) by competing with the enzyme for L-arginine.	Arginine	165-175	nitric oxide synthase 3	Homo sapiens	126-130
16479534-5	2006	In the case of calpain-2, a single iteration step involving LC-MS, provided the definitive residue specificity from which a highly sensitive fluorogenic substrate, (FAM)-Gly-Gly-Gly-Gln-Leu-Tyr-Gly-Gly-DPA-Arg-Arg-Lys-(TAMRA), was then designed.	Arginine	206-209	calpain 2	Homo sapiens	15-24
16650887-7	2006	However, L-NAME potentiated the dipsogenic effect of ANGII that is blocked by prior injection of nifedipine and L-arginine.	Arginine	112-122	angiotensinogen	Homo sapiens	53-58
16650887-11	2006	These data shows the correlation between L-type calcium channel and a free radical gas NO produced endogenously from amino acids L-arginine by endothelial and neuronal NO synthase in the control of ANGII-dipsogenic effect.	Arginine	129-139	angiotensinogen	Homo sapiens	198-203
16479534-5	2006	In the case of calpain-2, a single iteration step involving LC-MS, provided the definitive residue specificity from which a highly sensitive fluorogenic substrate, (FAM)-Gly-Gly-Gly-Gln-Leu-Tyr-Gly-Gly-DPA-Arg-Arg-Lys-(TAMRA), was then designed.	Arginine	210-213	calpain 2	Homo sapiens	15-24
16407226-7	2006	Altering the P1-P1" Arg-Asn sequence compromised Serp-1 protease-inhibitory activity and anti-inflammatory activity in animal models; P1-P1" Ala-Ala mutants were inactive, P1 Met increased remodeling, and P1" Thr increased thrombosis.	Arginine	20-23	stress associated endoplasmic reticulum protein 1	Homo sapiens	49-55
16497987-4	2006	Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline.	Arginine	184-194	nitric oxide synthase 3	Homo sapiens	73-77
16552814-8	2006	CONCLUSION: The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development.	Arginine	73-81	tumor protein p53	Homo sapiens	60-63
16406070-4	2006	Bicoid is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the critical 50th position (K50) of the homeodomain sequence, a residue required for DNA and RNA recognition; Bcd also has an arginine residue at the 54th position (R54), which is essential for RNA recognition.	Arginine	229-237	bicoid	Drosophila melanogaster	0-6
16406070-4	2006	Bicoid is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the critical 50th position (K50) of the homeodomain sequence, a residue required for DNA and RNA recognition; Bcd also has an arginine residue at the 54th position (R54), which is essential for RNA recognition.	Arginine	229-237	bicoid	Drosophila melanogaster	213-216
16428381-3	2006	Here the structure of the PGRP domain of Drosophila PGRP-LE in complex with tracheal cytotoxin (TCT), the monomeric DAP-type PGN, reveals a buried ionic interaction between the unique carboxyl group of DAP and a previously unrecognized arginine residue.	Arginine	236-244	Peptidoglycan recognition protein LE	Drosophila melanogaster	52-59
16543144-3	2006	Substitution of these lysine residues with arginines resulted in a dramatic decrease in overall ubiquitination but preserved normal tyrosine phosphorylation of EGFR.	Arginine	43-52	epidermal growth factor receptor	Homo sapiens	160-164
16253994-3	2006	The crystal packing of HPTP-B positions a normally surface-exposed arginine in a position equivalent to the tyrosyl substrate.	Arginine	67-75	protein tyrosine phosphatase receptor type B	Homo sapiens	23-29
16458291-5	2006	Furthermore, systemic arginine levels and arginine metabolism via nitric oxide synthase (NOS) can have profound effect on lung inflammation.	Arginine	22-30	nitric oxide synthase 2	Homo sapiens	66-87
16458291-5	2006	Furthermore, systemic arginine levels and arginine metabolism via nitric oxide synthase (NOS) can have profound effect on lung inflammation.	Arginine	42-50	nitric oxide synthase 2	Homo sapiens	66-87
16384887-1	2006	BACKGROUND: Nitric oxide is synthesized from the amino acid Arg by the enzyme endothelial nitric oxide synthase, which is competitively inhibited by the arginine metabolite asymmetric dimethylarginine (ADMA).	Arginine	60-63	nitric oxide synthase 3	Homo sapiens	78-111
16513984-2	2006	Here, we show that the protein tyrosine kinase Src arginine-388--&gt;alanine (R388A) mutant can be rescued in live cells with the use of the small molecule imidazole.	Arginine	51-59	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	47-50
16507366-3	2006	A peptide containing the ETGE motif of Nrf2 binds the beta propeller of Keap1 at the entrance of the central cavity on the bottom side via electrostatic interactions with conserved arginine residues.	Arginine	181-189	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
16507366-3	2006	A peptide containing the ETGE motif of Nrf2 binds the beta propeller of Keap1 at the entrance of the central cavity on the bottom side via electrostatic interactions with conserved arginine residues.	Arginine	181-189	kelch like ECH associated protein 1	Homo sapiens	72-77
16376159-1	2006	Nitric-oxide synthase (NOS) generates nitric oxide from l-arginine in two reaction cycles with N(omega)-hydroxy-l-arginine as an obligate intermediate.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	0-21
16384887-1	2006	BACKGROUND: Nitric oxide is synthesized from the amino acid Arg by the enzyme endothelial nitric oxide synthase, which is competitively inhibited by the arginine metabolite asymmetric dimethylarginine (ADMA).	Arginine	153-161	nitric oxide synthase 3	Homo sapiens	78-111
16489746-2	2006	Correlating with a Val-to-Ile residue substitution in the bsNOS heme pocket, the Fe(II)-NO complex with both l-Arg and NOHA is more bent than the Fe(II)-NO, l-Arg complex of mammalian eNOS [Li, H., Raman, C. S., Martasek, P., Masters, B. S. S., and Poulos, T. L. (2001) Biochemistry 40, 5399-5406].	Arginine	109-114	nitric oxide synthase 3	Homo sapiens	184-188
16476058-3	2006	Interferon-gamma was essential to trigger suppression, which, by enzyme inhibition studies, was shown to be the result of tryptophan and arginine catabolism.	Arginine	137-145	interferon gamma	Mus musculus	0-16
16476977-7	2006	Thirdly, the requirement of the arginine and lysine clusters for Nef-mediated CD4 down modulation was shown to correlate precisely with membrane association.	Arginine	32-40	S100 calcium binding protein B	Homo sapiens	65-68
16476977-7	2006	Thirdly, the requirement of the arginine and lysine clusters for Nef-mediated CD4 down modulation was shown to correlate precisely with membrane association.	Arginine	32-40	CD4 molecule	Homo sapiens	78-81
16478467-2	2006	The Arg-Phe part in SP-Ci that is cleaved to generate SP-C is localized in a turn structure, which is followed by a short segment in extended conformation.	Arginine	4-7	surfactant protein C	Homo sapiens	20-24
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	15-23	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	50-53
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	15-23	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	144-147
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	25-28	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	50-53
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	25-28	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	144-147
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	195-198	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	50-53
16484187-2	2006	Conserved twin arginine (Arg) residues within the Tat signal sequence consensus motif (S/TRRxFLK) are considered essential for the secretion of Tat substrates, but some exceptions (e.g., Lys and Arg) to the twin Arg residues in this motif have been noted.	Arginine	195-198	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	50-53
16646561-2	2006	The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis.	Arginine	90-98	tumor protein p53	Homo sapiens	43-46
16646561-2	2006	The codon 72 polymorphism on exon 4 in the p53 gene produces variant proteins with either arginine (Arg) or proline (Pro), and is associated with an increased susceptibility of cancers of the lung, esophagus, breast, cervix and nasopharynx on a genetic basis.	Arginine	100-103	tumor protein p53	Homo sapiens	43-46
16646561-8	2006	As the frequency of p53 Arg allele increased, the cancer was of a more poorly differentiated type.	Arginine	24-27	tumor protein p53	Homo sapiens	20-23
16646561-10	2006	Increased frequency of p53 Arg allele is associated with more poorly differentiated cancers.	Arginine	27-30	tumor protein p53	Homo sapiens	23-26
16569330-6	2006	DNA was extracted from the buccal swabs and PCR amplification of p53 arginine(Arg)72 and proline(Pro)72 variants was performed.	Arginine	69-77	tumor protein p53	Homo sapiens	65-68
16318864-6	2006	After adjustment for other possible confounders, the incidence of p53 overexpression was significantly decreased in patients with Pro/Pro genotype with an odds ratio (OR) of 0.21 (95% CI: 0.067-0.64) (p = 0.0065) compared with incidence in patients with Arg/Arg genotype.	Arginine	254-257	tumor protein p53	Homo sapiens	66-69
16318864-6	2006	After adjustment for other possible confounders, the incidence of p53 overexpression was significantly decreased in patients with Pro/Pro genotype with an odds ratio (OR) of 0.21 (95% CI: 0.067-0.64) (p = 0.0065) compared with incidence in patients with Arg/Arg genotype.	Arginine	258-261	tumor protein p53	Homo sapiens	66-69
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Arginine	179-182	tumor protein p53	Homo sapiens	87-90
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Arginine	183-186	tumor protein p53	Homo sapiens	87-90
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Arginine	183-186	tumor protein p53	Homo sapiens	87-90
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Arginine	183-186	tumor protein p53	Homo sapiens	87-90
16318864-11	2006	There was also a higher incidence of, but without reaching a statistical significance, p53 mutation in patients with p53 overexpression (OR[95% CI]: 2.18 [0.52-9.6]) and codon 72 Arg/Arg genotype (OR [95% CI] of 0.8 [0.13-4.2], comparing genotypes of Pro/Pro and Arg/Pro with Arg/Arg).	Arginine	183-186	tumor protein p53	Homo sapiens	87-90
16337930-1	2006	Reanalysis of the tryptic digests of soybean seed coat peroxidase (SBP) and its carboxyamidated peptide derivatives in the light of more complete sequence data has thrown light on the diglycosylated tryptic peptides, TP13 (Leu[183-205]Arg) and TP15 (Cys[208-231]Arg).	Arginine	235-238	peroxidase	Glycine max	55-65
16293633-0	2006	The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6.	Arginine	91-99	serpin family A member 1	Homo sapiens	84-87
16337930-1	2006	Reanalysis of the tryptic digests of soybean seed coat peroxidase (SBP) and its carboxyamidated peptide derivatives in the light of more complete sequence data has thrown light on the diglycosylated tryptic peptides, TP13 (Leu[183-205]Arg) and TP15 (Cys[208-231]Arg).	Arginine	235-238	sucrose-binding protein 2	Glycine max	67-70
16467084-9	2006	Purified hK11 possesses trypsin-like activity and cleaves synthetic peptides after arginine but not lysine residues.	Arginine	83-91	kallikrein related peptidase 11	Homo sapiens	9-13
16360110-6	2006	By using this method, the K(m) value of Arg and the K(i) value of l-NMMA for iNOS were determined to be 12.6 and 6.1muM, respectively.	Arginine	40-43	nitric oxide synthase 2	Homo sapiens	77-81
16418283-4	2006	These results suggest that TM functions by alleviating the Ca(2+)-dependent inhibitory interactions of Arg-67 of protein C and Arg-35 of thrombin.	Arginine	127-130	coagulation factor II, thrombin	Homo sapiens	137-145
16291705-12	2006	Three other patients, with elevated fasting plasma glucose levels, demonstrated a very low insulin response under glucose stimulation and a low insulin response under arginine stimulation.	Arginine	167-175	insulin	Homo sapiens	144-151
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Arginine	96-99	WT1 transcription factor	Homo sapiens	21-24
16479084-3	2006	Direct sequencing of WT1 PCR products from genomic DNA identified WT1 mutations in exons 8 (366 Arg&gt;His) and 9 (396 Asp&gt;Tyr).	Arginine	96-99	WT1 transcription factor	Homo sapiens	66-69
16321856-6	2006	The c-kit mutations in exon 11 occurred at codon 558 (AAG --&gt; TAG; Lys --&gt; Stop) and at codon 571 (CTA --&gt; ATA; Leu --&gt; Ile), respectively, while the mutation in exon 13 occurred at codon 634 (CGG --&gt; CGA; Arg --&gt; Arg).	Arginine	221-224	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
16321856-6	2006	The c-kit mutations in exon 11 occurred at codon 558 (AAG --&gt; TAG; Lys --&gt; Stop) and at codon 571 (CTA --&gt; ATA; Leu --&gt; Ile), respectively, while the mutation in exon 13 occurred at codon 634 (CGG --&gt; CGA; Arg --&gt; Arg).	Arginine	232-235	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
16329147-1	2006	Arginine is catabolized by NOS2 and other nitric oxide synthases to form nitric oxide.	Arginine	0-8	nitric oxide synthase 2, inducible	Mus musculus	27-31
16329147-5	2006	When diet was supplemented with arginine (0.2% and 2% in drinking water), lack of Nos2 results in decreased tumorigenesis in both small intestine and colon.	Arginine	32-40	nitric oxide synthase 2, inducible	Mus musculus	82-86
16329147-6	2006	In Nos2 knockout mice, supplemental arginine (up to 2%) caused a decrease in small intestinal tumor number and size.	Arginine	36-44	nitric oxide synthase 2, inducible	Mus musculus	3-7
16329147-11	2006	Mice lacking Nos2 did not show changes in tumorigenesis or nitrotyrosine formation, while demonstrating an arginine-dependent increase in apoptosis.	Arginine	107-115	nitric oxide synthase 2, inducible	Mus musculus	13-17
16329147-13	2006	In both tissues, loss of Nos2 is associated with decreased tumorigenesis when mice are supplemented with dietary arginine.	Arginine	113-121	nitric oxide synthase 2, inducible	Mus musculus	25-29
16329147-14	2006	In the small intestine, Nos2 prevents the arginine-induced decrease in tumor number and size, which is associated with NOS3 expression and increased apoptosis.	Arginine	42-50	nitric oxide synthase 2, inducible	Mus musculus	24-28
16329147-15	2006	In the colon, Nos2 is required for the arginine-induced increase in tumor number and incidence.	Arginine	39-47	nitric oxide synthase 2, inducible	Mus musculus	14-18
16428394-6	2006	The lack of activity of B. burgdorferi"s ThyX protein was associated with the substitution of a cysteine for a highly conserved arginine at position 91.	Arginine	128-136	thyX	Borrelia hermsii	41-45
16610237-7	2006	RESULTS: All patients were homozygous for a novel GHRH-R missense mutation in exon 11 that replaces arginine with cysteine (R357C).	Arginine	100-108	growth hormone releasing hormone receptor	Homo sapiens	50-56
16525354-10	2006	Lymphocyte interferon-gamma expression in the Arg groups was significantly lower, whereas interleukin (IL)-4 expression was higher than the control group at various time points after CLP.	Arginine	46-49	interferon gamma	Mus musculus	11-27
16525354-11	2006	The expression of lymphocyte CD11a/CD18 was significantly higher in the Arg group 6, 12, and 24 h after CLP than those of the corresponding control group and the NC group.	Arginine	72-75	integrin beta 2	Mus musculus	35-39
16525354-12	2006	PMN expressions of CD11b/CD18 in the Arg groups were higher than those in the control group at 12 and 24 h after CLP.	Arginine	37-40	integrin alpha M	Mus musculus	19-24
16525354-12	2006	PMN expressions of CD11b/CD18 in the Arg groups were higher than those in the control group at 12 and 24 h after CLP.	Arginine	37-40	integrin beta 2	Mus musculus	25-29
16525354-13	2006	The Arg group had higher IL-6 levels at 6 and 12 h in the kidney and intestine and 12 h in the lung after CLP.	Arginine	4-7	interleukin 6	Mus musculus	25-29
16525354-16	2006	In addition, Arg supplementation reduced intracellular interferon-gamma and enhanced IL-4 expression.	Arginine	13-16	interferon gamma	Mus musculus	55-71
16430223-10	2006	We identified arginine-177 as the modification site for C/SpvB with the actin homologue protein Act88F from Drosophila.	Arginine	14-22	Actin 88F	Drosophila melanogaster	96-102
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Arginine	140-148	coagulation factor II, thrombin	Homo sapiens	0-8
16409620-6	2006	Furthermore, the role of substrate availability to nNOS was measured in the presence of exogenous L-arginine (5.0 mM).	Arginine	98-108	nitric oxide synthase, brain	Cavia porcellus	51-55
20641599-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	fibrinogen beta chain	Homo sapiens	149-159
16699611-4	2006	AIM: To investigate the possible association between p53 arginine/72 proline polymorphism and susceptibility to colorectal cancer.	Arginine	57-65	tumor protein p53	Homo sapiens	53-56
17113725-1	2006	BACKGROUND: A common Arg/Pro polymorphism at codon 72 of the TP53 gene has been investigated as a risk factor for cancer in different populations.	Arginine	21-24	tumor protein p53	Homo sapiens	61-65
17168727-3	2006	Many enzymes display a preference for the arginine residue that is found in many natural substrates and in synthetic inhibitors of many trypsin-like serine proteases, e.g. thrombin, factor Xa, factor VIIa, trypsin, and in integrin receptor antagonists, used to treat many blood-coagulation disorders.	Arginine	42-50	coagulation factor II, thrombin	Homo sapiens	172-180
17168727-4	2006	Nitric oxide (NO), which is produced by oxidation of L-arginine in an NADPH- and O(2)-dependent process catalyzed by isoforms of nitric oxide synthase (NOS), exhibits diverse roles in both normal and pathological physiologies and has been postulated to be a contributor to the etiology of various diseases.	Arginine	53-63	nitric oxide synthase 2	Homo sapiens	129-150
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	40-48	coagulation factor II, thrombin	Homo sapiens	150-158
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	40-48	nitric oxide synthase 2	Homo sapiens	248-269
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Arginine	212-220	poly(ADP-ribose) glycohydrolase	Homo sapiens	118-122
16482626-11	2006	RESULTS: L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio (pw/bw), the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values.	Arginine	9-14	interleukin 6	Rattus norvegicus	201-205
16482626-15	2006	In the liver, L-Arg significantly increased the lipid peroxidation level, and the glutathione peroxidase and Cu/Zn-SOD activities, whereas the Mn-SOD activity was reduced as compared to the control rats.	Arginine	14-19	superoxide dismutase 1	Rattus norvegicus	109-118
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	96-104	coagulation factor II, thrombin	Homo sapiens	150-158
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	96-104	nitric oxide synthase 2	Homo sapiens	248-269
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Arginine	196-199	tumor necrosis factor	Homo sapiens	13-16
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Arginine	196-199	tumor necrosis factor	Homo sapiens	51-54
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Arginine	209-212	tumor necrosis factor	Homo sapiens	13-16
16923618-4	2006	METHODS: The TNF mutant (recombinant mutated human TNF; rmhTNF) was prepared by protein engineering in which amino acids Pro, Ser and Asp at positions 8, 9 and 10 of TNF-alpha were substituted by Arg, Lys and Arg, and C terminal Leu157 was substituted by Phe, along with deletion of the first seven N-terminal amino acids.	Arginine	209-212	tumor necrosis factor	Homo sapiens	51-54
16883952-1	2006	Nitric oxide (NO) is a gas with diverse biological activities produced from L-arginine by nitric oxide synthetase (NOS).	Arginine	76-86	nitric oxide synthase 2	Homo sapiens	90-113
16403019-7	2006	Furthermore, we show by in vitro binding assays that AIRE interacts with multiple members of the nuclear transport receptor importin alpha family, mainly alpha1, alpha3, and alpha5, and that these interactions depend on the intactness of the Arg-Lys-rich NLS of AIRE.	Arginine	242-245	autoimmune regulator	Homo sapiens	53-57
16896365-4	2006	P53 gene polymorphisms include codon11 Glu/Gln or Lys (GAG-&gt;CAG or AAG), codon 72 Arg/Pro (CGC-&gt;CCC), and codon 248 Arg/Thr (CGG-&gt;TCG).	Arginine	85-88	tumor protein p53	Homo sapiens	0-3
16245368-8	2006	In addition, Y764 is in position to make an electrostatic contact after phosphorylation with a conserved SFK arginine that mediates interactions with other high-affinity SH2 binders.	Arginine	109-117	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
16205964-2	2006	The TK inhibitor imatinib mesylate selectively targets PDGFR-alpha, -beta, c-kit, c-abl and arg and has proven successful in the treatment of chronic myeloid leukaemia.	Arginine	48-51	platelet derived growth factor receptor alpha	Homo sapiens	55-73
16205964-2	2006	The TK inhibitor imatinib mesylate selectively targets PDGFR-alpha, -beta, c-kit, c-abl and arg and has proven successful in the treatment of chronic myeloid leukaemia.	Arginine	48-51	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	75-80
16205964-10	2006	We show here for the first time in a large series of glioblastomas that PDGFR-alpha, -beta, c-kit, c-abl and arg expression is immunohistochemically detectable in a fraction of cases.	Arginine	38-41	platelet derived growth factor receptor alpha	Homo sapiens	72-90
16205964-10	2006	We show here for the first time in a large series of glioblastomas that PDGFR-alpha, -beta, c-kit, c-abl and arg expression is immunohistochemically detectable in a fraction of cases.	Arginine	38-41	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	92-97
16362283-8	2006	When relating the variables obtained from the arginine test to insulin sensitivity, insulin resistance was associated with increased AGR and with increased suppression of glucagon levels by glucose.	Arginine	46-54	insulin	Homo sapiens	63-70
16362283-8	2006	When relating the variables obtained from the arginine test to insulin sensitivity, insulin resistance was associated with increased AGR and with increased suppression of glucagon levels by glucose.	Arginine	46-54	insulin	Homo sapiens	84-91
16362283-11	2006	CONCLUSIONS/INTERPRETATION: The body adapts to insulin resistance by increasing the glucagon response to arginine and by increasing the suppression of glucagon levels by glucose.	Arginine	105-113	insulin	Homo sapiens	47-54
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	73-76	tumor protein p53	Homo sapiens	14-17
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	77-80	tumor protein p53	Homo sapiens	14-17
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	77-80	tumor protein p53	Homo sapiens	14-17
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	77-80	tumor protein p53	Homo sapiens	14-17
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	77-80	tumor protein p53	Homo sapiens	14-17
16168468-3	2006	RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301).	Arginine	77-80	tumor protein p53	Homo sapiens	14-17
16168468-6	2006	CONCLUSION: Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population.	Arginine	23-26	tumor protein p53	Homo sapiens	46-49
16883953-1	2006	Nitric oxide (NO) is a gas with diverse biological activities produced from arginine by nitric oxide synthetase (NOS).	Arginine	76-84	nitric oxide synthase 2	Homo sapiens	88-111
16451208-4	2006	Interestingly, a protective DRB1*07 allele in Thai population lacks an arginine at position 74 similar to DRB1*0311 (a protective allele in Caucasians).	Arginine	71-79	major histocompatibility complex, class II, DR beta 1	Homo sapiens	28-32
17065069-3	2006	We homozygously identified the CGA insertion after A666 of the MOCS1 gene which produces arginine insertion at codon 222 of MOCS1A.	Arginine	89-97	chromogranin A	Homo sapiens	31-34
16554913-9	2006	Our results suggest that Arg allele at codon 72 of p53 gene might affect the risk of ultraviolet-induced basal cell carcinoma.	Arginine	25-28	tumor protein p53	Homo sapiens	51-54
16223957-9	2006	In summary, we have identified a new highly selective iNOS inhibitor structurally unrelated to known compounds and l-arginine.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	54-58
16450583-5	2006	The mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene led to the infertility in the patients.	Arginine	31-39	catalase	Homo sapiens	44-47
16450583-5	2006	The mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene led to the infertility in the patients.	Arginine	31-39	androgen receptor	Homo sapiens	63-65
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Arginine	163-171	catalase	Homo sapiens	176-179
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Arginine	163-171	androgen receptor	Homo sapiens	195-197
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Arginine	163-171	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	272-275
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Arginine	259-267	catalase	Homo sapiens	176-179
16450583-7	2006	The clinical phenotype of theirs presented more deleteriously than and different from the one reported before, though they had the same mutation of codon 840 CGT (arginine) to CAT (histidine) of AR gene, which was very different from the mutation of 840 CGT (arginine) to TGT (cysteine) at the same codon.	Arginine	259-267	androgen receptor	Homo sapiens	195-197
16263090-5	2005	Characterization of the FGF3 binding domain of rpS2 showed that both the Arg-Gly-rich N-terminal region and a short carboxyl-terminal sequence of rpS2 are necessary for FGF3 binding.	Arginine	73-76	ribosomal protein S2	Homo sapiens	47-51
16256071-2	2005	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PxxxPR) found in several CIN85 effectors.	Arginine	73-81	SH3 domain containing kinase binding protein 1	Homo sapiens	0-5
16256071-2	2005	CIN85 contains three SH3 domains that specifically bind a unique proline-arginine motif (PxxxPR) found in several CIN85 effectors.	Arginine	73-81	SH3 domain containing kinase binding protein 1	Homo sapiens	114-119
16167335-8	2005	TNF-alpha-induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor (10(-8) M), while LPS- or Bay K 8644-induced decrease in cell number was significantly prevented by caspase-3 inhibitor or N omega-nitro-L-arginine methylester (NAME) (10(-5) M), an inhibitor of nitric oxide (NO) synthase.	Arginine	262-271	tumor necrosis factor	Rattus norvegicus	0-9
17236649-1	2006	It is widely recognized that nitric oxide (NO) in mammalian tissues is produced from L-arginine via catalysis by NO synthase (NOS) isoforms such as neuronal NOS (nNOS) and endothelial NOS (eNOS) that are constitutively expressed mainly in the central and peripheral nervous system and vascular endothelial cells, respectively.	Arginine	85-95	nitric oxide synthase 3	Homo sapiens	172-187
16294045-0	2005	The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.	Arginine	26-34	BP1	Homo sapiens	19-22
16429495-18	2005	We have made the homologous mutation in the mouse AChE and BuChE genes and showed that the Arg to Cys mutations resulted in identical alterations in the cellular phenotype for the various members of the alpha/beta-hydrolase fold family proteins.	Arginine	91-94	butyrylcholinesterase	Mus musculus	59-64
16040184-6	2005	Under stimulated conditions, arginine decreased IL-8 and Mig mRNA level (57% and 39%, for 0.1 vs. 2 mmol/l l-arginine, P&lt;0.05, respectively), and production (respectively, 28 and 23%, both P&lt;0.05).	Arginine	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	48-52
16040184-6	2005	Under stimulated conditions, arginine decreased IL-8 and Mig mRNA level (57% and 39%, for 0.1 vs. 2 mmol/l l-arginine, P&lt;0.05, respectively), and production (respectively, 28 and 23%, both P&lt;0.05).	Arginine	29-37	C-X-C motif chemokine ligand 9	Homo sapiens	57-60
16040184-9	2005	Use of NG-Methyl-l-arginine acetate, a NOS inhibitor which prevents arginine-induced NO production, suppressed the arginine-induced IL-8 inhibition (P&lt;0.05).	Arginine	19-27	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16040184-9	2005	Use of NG-Methyl-l-arginine acetate, a NOS inhibitor which prevents arginine-induced NO production, suppressed the arginine-induced IL-8 inhibition (P&lt;0.05).	Arginine	68-76	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
16040184-10	2005	In HCT-8 cells, arginine enhanced cytokine-induced NO production, reduced IL-8 and Mig production and mRNA level and had no effects on other assessed chemokines.	Arginine	16-24	C-X-C motif chemokine ligand 8	Homo sapiens	74-78
16040184-10	2005	In HCT-8 cells, arginine enhanced cytokine-induced NO production, reduced IL-8 and Mig production and mRNA level and had no effects on other assessed chemokines.	Arginine	16-24	C-X-C motif chemokine ligand 9	Homo sapiens	83-86
16040184-11	2005	In conclusion, arginine-induced IL-8 inhibition in HCT-8 cells involves NO pathway under inflammatory conditions.	Arginine	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
16357143-7	2005	The CDC4 mutation spectrum in colorectal tumors was heavily biased towards C:G &gt; T:A changes, either missense mutations at critical arginine residues or nonsense changes in the 5" half of the gene.	Arginine	135-143	F-box and WD-40 domain protein 7	Mus musculus	4-8
16294045-3	2005	Herein, we show that the GAR motif of 53BP1 is arginine methylated by protein arginine methyltransferase 1 (PRMT1), the same methyltransferase that methylates MRE11.	Arginine	47-55	MRE11 homolog, double strand break repair nuclease	Homo sapiens	159-164
16354872-7	2005	CONCLUSIONS: HPV detected in a small proportion of lung cancer patients in India demonstrated an exclusive prevalence of HPV type 18, and there was a significantly higher frequency of p53 Arg/Arg genotype when compared to that of control subjects.	Arginine	188-191	tumor protein p53	Homo sapiens	184-187
16354872-7	2005	CONCLUSIONS: HPV detected in a small proportion of lung cancer patients in India demonstrated an exclusive prevalence of HPV type 18, and there was a significantly higher frequency of p53 Arg/Arg genotype when compared to that of control subjects.	Arginine	192-195	tumor protein p53	Homo sapiens	184-187
16354872-8	2005	Observation of a shorter duration of symptoms (&lt; or = 4 months) in as many as 78% (seven of nine stage IV patients) with Arg/Pro genotype may be an indication that lung cancer patients with the heterozygous p53 genotype are more susceptible to early progression.	Arginine	124-127	tumor protein p53	Homo sapiens	210-213
16362795-2	2005	TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix.	Arginine	55-63	tumor protein p53	Homo sapiens	0-4
16362795-2	2005	TP53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, oesophagus, stomach and cervix.	Arginine	65-68	tumor protein p53	Homo sapiens	0-4
16362795-9	2005	The allele frequencies of the TP53 polymorphism were: Arg=0.74 and Pro=0.26.	Arginine	54-57	tumor protein p53	Homo sapiens	30-34
16154758-9	2005	The most potent stimulant properties disclosed PP(Phe)(2)Arg(2) derivative for which the highest values of IL-1beta, IL-6 and NO(2)(-) were noticed.	Arginine	57-60	interleukin 1 beta	Mus musculus	107-115
16415763-5	2005	Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine.	Arginine	361-369	insulin	Homo sapiens	45-52
16503867-5	2005	Recently, much attention has focused on a naturally occurring variant of apoA-I, apoA-I(Milano) (apoA-IM) characterized by a cysteine for arginine substitution that is associated with low rates of vascular disease and significant longevity in its carriers, despite markedly reduced HDL and elevated triglyceride levels.	Arginine	138-146	apolipoprotein A1	Homo sapiens	73-79
16503867-5	2005	Recently, much attention has focused on a naturally occurring variant of apoA-I, apoA-I(Milano) (apoA-IM) characterized by a cysteine for arginine substitution that is associated with low rates of vascular disease and significant longevity in its carriers, despite markedly reduced HDL and elevated triglyceride levels.	Arginine	138-146	apolipoprotein A1	Homo sapiens	81-95
16251196-2	2005	A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome.	Arginine	120-128	cyclin CLN3	Saccharomyces cerevisiae S288C	41-45
16251196-2	2005	A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome.	Arginine	120-128	cyclin CLN3	Saccharomyces cerevisiae S288C	95-99
16332483-7	2005	Prolonged incubation of LPS (24 hours, 25 microg/ml) resulted in a 3-fold increase of arginine transport activity (control: 28 +/- 5; LPS: 92 +/- 20 pmol/mg/min, P &lt; 0.05), with the System y(+) as the predominant arginine transport system, and a 2-fold increase of System y(+)CAT1 mRNA and transporter protein levels (P &lt; 0.05).	Arginine	86-94	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	279-283
16154758-9	2005	The most potent stimulant properties disclosed PP(Phe)(2)Arg(2) derivative for which the highest values of IL-1beta, IL-6 and NO(2)(-) were noticed.	Arginine	57-60	interleukin 6	Mus musculus	117-121
16141432-11	2005	These data suggest that pathways of arginine metabolism and the importance of nitric oxide may differ in OVA- and TMA-induced asthma.	Arginine	36-44	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	105-108
15979761-0	2005	Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide.	Arginine	129-132	cholecystokinin	Homo sapiens	119-122
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	121-124	cholecystokinin	Homo sapiens	110-113
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	cholecystokinin	Homo sapiens	110-113
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	cholecystokinin	Homo sapiens	110-113
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	cholecystokinin	Homo sapiens	110-113
16262729-10	2005	Changing the glutamate to arginine as found in GLUT4 (RRXXXLL) alters GLUT8 endocytosis and retains the transporter at the PM.	Arginine	26-34	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	47-52
16262729-10	2005	Changing the glutamate to arginine as found in GLUT4 (RRXXXLL) alters GLUT8 endocytosis and retains the transporter at the PM.	Arginine	26-34	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	70-75
16183331-2	2005	Septic conditions are, however, associated with excessive formation of nitric oxide (NO), which is formed from l-arginine by the inducible NO synthase (iNOS) activity.	Arginine	111-121	nitric oxide synthase 2	Rattus norvegicus	129-150
16183331-2	2005	Septic conditions are, however, associated with excessive formation of nitric oxide (NO), which is formed from l-arginine by the inducible NO synthase (iNOS) activity.	Arginine	111-121	nitric oxide synthase 2	Rattus norvegicus	152-156
16270151-6	2005	All isoforms of BmTRA-2 protein contain two arginine/serine-rich domains and one RNA recognition motif, showing striking organizational similarity to Drosophila TRA-2 proteins.	Arginine	44-52	transformer 2	Bombyx mori	16-23
16147996-9	2005	Inhibition of this binding by acetylation and cyclohexanedione treatment of LDL showed that the positively charged amino acids of apolipoprotein B-100, lysine, and arginine, respectively, mediated the ionic interaction.	Arginine	164-172	apolipoprotein B	Homo sapiens	130-150
16116642-2	2005	Prior reports have demonstrated that increased nitric oxide production via L-arginine treatment of normal and mdx mice resulted in increased expression of utrophin and increased activation of muscle satellite cells, which could ameliorate the dystrophic pathology.	Arginine	75-85	utrophin	Mus musculus	155-163
16116642-8	2005	Together, these results show that L-arginine treatment can be beneficial to mdx muscle function, perhaps through a combination of enhanced calcium handling and increased utrophin, thereby decreasing muscle degeneration.	Arginine	34-44	utrophin	Mus musculus	170-178
16307686-2	2005	Furthermore, the polymorphism at codon 72 (encoding either arginine or proline) of the p53 tumor-suppressor gene is discussed as a possible determinant for cancer risk.	Arginine	59-67	tumor protein p53	Homo sapiens	87-90
16291938-5	2005	In the CSF, Arg-61 apoE level was 40% lower than the wild-type level.	Arginine	12-15	apolipoprotein E	Mus musculus	19-23
16291938-6	2005	Arg-61 apoE mRNA levels were similar to or slightly higher than wild-type apoE mRNA levels.	Arginine	0-3	apolipoprotein E	Mus musculus	7-11
16291938-7	2005	Thus, the lower Arg-61 apoE levels were not attributable to decreased mRNA levels.	Arginine	16-19	apolipoprotein E	Mus musculus	23-27
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	36-39	apolipoprotein E	Homo sapiens	105-110
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	36-39	apolipoprotein E	Homo sapiens	105-110
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	89-92	apolipoprotein E	Homo sapiens	57-62
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	89-92	apolipoprotein E	Mus musculus	57-61
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	89-92	apolipoprotein E	Homo sapiens	57-62
16291938-8	2005	In culture medium from heterozygous Arg-61/wild-type and apoE4/apoE3 primary astrocytes, Arg-61 apoE and apoE4 levels were lower than wild-type apoE and apoE3, respectively, suggesting that primary astrocytes secrete lower amounts of Arg-61 apoE and apoE4.	Arginine	89-92	apolipoprotein E	Mus musculus	57-61
16291938-9	2005	These results demonstrate that domain interaction is responsible for the lower levels of both human apoE4 and mouse Arg-61 apoE in mouse brain.	Arginine	116-119	apolipoprotein E	Homo sapiens	100-105
16291938-9	2005	These results demonstrate that domain interaction is responsible for the lower levels of both human apoE4 and mouse Arg-61 apoE in mouse brain.	Arginine	116-119	apolipoprotein E	Mus musculus	100-104
16254053-9	2005	Previous work has shown that CARM1 can methylate CBP at three arginine residues.	Arginine	62-70	CREB binding protein	Homo sapiens	49-52
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	67-75	CREB binding protein	Homo sapiens	36-39
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	67-75	CREB binding protein	Homo sapiens	36-39
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	67-75	interferon gamma	Homo sapiens	149-158
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	105-113	CREB binding protein	Homo sapiens	16-19
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	105-113	CREB binding protein	Homo sapiens	36-39
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	105-113	CREB binding protein	Homo sapiens	36-39
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	105-113	interferon gamma	Homo sapiens	149-158
16388095-12	2005	Examination of its functional expression using L-arginine (1 microM) yielded a 35% increase in GH release from cultured GH-secreting adenoma.	Arginine	47-57	growth hormone 1	Homo sapiens	95-97
16027960-3	2005	Arginine also led to significant increases in alpha-ketoglutarate, pyruvate, MPO release and H2O2 generation.	Arginine	0-8	myeloperoxidase	Homo sapiens	77-80
16227835-5	2005	RESULTS: A novel heterozygous missense mutation (1508G--&gt;C), predicting the substitution of a proline for an arginine (R503P) was detected in the helix termination motif of the keratin 3 polypeptide in family 1.	Arginine	112-120	keratin 3	Homo sapiens	180-189
16388095-12	2005	Examination of its functional expression using L-arginine (1 microM) yielded a 35% increase in GH release from cultured GH-secreting adenoma.	Arginine	47-57	growth hormone 1	Homo sapiens	120-122
16131575-1	2005	CONTEXT: The insulin tolerance test (ITT) is the current standard diagnostic test for the diagnosis of adult GH deficiency (GHD), but alternative tests, such as the GHRH-arginine test, have been proposed.	Arginine	170-178	growth hormone releasing hormone	Homo sapiens	165-169
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	signal transducer and activator of transcription 3	Mus musculus	28-33
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	signal transducer and activator of transcription 3	Mus musculus	122-127
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	interleukin 6	Mus musculus	152-156
16131575-2	2005	OBJECTIVE: We investigated the sensitivity and specificity of the GHRH-arginine test using ITT as the gold standard in diagnosing GHD in a group of young adults treated with cranial irradiation (CRT) for childhood acute lymphoblastic leukemia (ALL).	Arginine	71-79	growth hormone releasing hormone	Homo sapiens	66-70
16131575-7	2005	In contrast, a failed GH response to the GHRH-arginine test accurately reflects the presence of radiation-induced GHD, illustrated by a high positive predictive value (95% at 7.5 microg/liter).	Arginine	46-54	growth hormone releasing hormone	Homo sapiens	41-45
16131575-8	2005	Only age at CRT and body mass index remained significant predictors of the peak GH during the GHRH-arginine test.	Arginine	99-107	growth hormone releasing hormone	Homo sapiens	94-98
16131575-9	2005	Because a high proportion of GHD patients show a normal response to the GHRH-arginine test, it cannot be used reliably to exclude GHD in these patients.	Arginine	77-85	growth hormone releasing hormone	Homo sapiens	72-76
16244137-1	2005	Urease is a nickel-containing urea hydrolase involved in nitrogen recycling from ureide, purine, and arginine catabolism in plants.	Arginine	101-109	urease	Arabidopsis thaliana	0-6
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Arginine	77-80	nitric oxide synthase 2	Rattus norvegicus	118-139
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Arginine	77-80	nitric oxide synthase 2	Rattus norvegicus	141-145
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Arginine	125-133	SH3 domain containing kinase binding protein 1	Homo sapiens	84-89
16272249-3	2005	Among groups acclimated to cold, higher iNOS immunopositivity and protein levels were detected only in the L-Arg-treated group.	Arginine	107-112	nitric oxide synthase 2	Rattus norvegicus	40-44
16272249-4	2005	Furthermore, chronic L-Arg treatment increased IBAT mass and UCP1 protein content, while L-NAME had an opposite effect, decreasing both IBAT mass and UCP1 protein level, as compared to the control maintained at 4+/-1 degrees C. These data suggest that nitric oxide (NO) produced by iNOS could also contribute to overall NO-associated regulation of thermogenesis in IBAT.	Arginine	21-26	uncoupling protein 1	Rattus norvegicus	61-65
16272249-4	2005	Furthermore, chronic L-Arg treatment increased IBAT mass and UCP1 protein content, while L-NAME had an opposite effect, decreasing both IBAT mass and UCP1 protein level, as compared to the control maintained at 4+/-1 degrees C. These data suggest that nitric oxide (NO) produced by iNOS could also contribute to overall NO-associated regulation of thermogenesis in IBAT.	Arginine	21-26	nitric oxide synthase 2	Rattus norvegicus	282-286
16131491-0	2005	A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families.	Arginine	112-120	solute carrier family 10 member 5	Homo sapiens	108-111
16358225-12	2005	The [14C] arginine uptake by rBAT1 was unchanged by the treatment with antisense ODN.	Arginine	10-18	DExD-box helicase 39B	Rattus norvegicus	29-34
16239632-5	2005	RESULTS: A glutamine (Gln)/arginine (Arg) polymorphism at amino acid residue 192 in PON1 was significantly associated with stroke (P=0.003 in multivariate analysis, including age, sex, LDL, hypertension, diabetes, smoking, and pravastatin treatment as covariates).	Arginine	27-35	paraoxonase 1	Homo sapiens	84-88
16239632-5	2005	RESULTS: A glutamine (Gln)/arginine (Arg) polymorphism at amino acid residue 192 in PON1 was significantly associated with stroke (P=0.003 in multivariate analysis, including age, sex, LDL, hypertension, diabetes, smoking, and pravastatin treatment as covariates).	Arginine	37-40	paraoxonase 1	Homo sapiens	84-88
15996770-5	2005	NO synthase inhibitors blocked the GRP effect on lymphocyte chemotaxis, and this action was reversed in the presence of l-arginine.	Arginine	120-130	gastrin releasing peptide	Mus musculus	35-38
16131491-1	2005	Most basophilic serine/threonine kinases preferentially phosphorylate substrates with Arg at P-3 but vary greatly in additional strong preference for Arg at P-2 or P-5.	Arginine	86-89	exosome component 10	Homo sapiens	93-96
16131491-5	2005	Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4).	Arginine	18-21	solute carrier family 10 member 5	Homo sapiens	14-17
16131491-6	2005	Analysis of sequence conservation demonstrated almost perfect correlation between (a) strong P-2 or P-5 Arg preference and (b) acidic residues at both PEN+1 and YEM+1.	Arginine	104-107	solute carrier family 10 member 5	Homo sapiens	93-103
16140268-3	2005	A previous study demonstrated that STAT3 with Arg-214/215 mutations in the coiled-coil domain (R214A/R215A; STAT3 RA) failed to undergo nuclear translocation.	Arginine	46-49	signal transducer and activator of transcription 3	Homo sapiens	35-40
16229464-1	2005	The enzymes dimethylargininase [dimethylarginine dimethylaminohydrolase (DDAH); EC 3.5.3.18] and peptidylarginine deiminase (PAD; EC 3.5.3.15) catalyze hydrolysis of substituted arginines.	Arginine	178-187	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	73-77
16087676-3	2005	Using high resolution accurate mass analysis on an ion trap Fourier transform mass spectrometer, the post-translational modification was identified as arginine linked to the gamma-carboxyl of Glu via an isopeptide bond, and we named the newly identified peptide "arginylated neurotensin" (R-NT, N-(neurotensin-C5-4-yl)arginine).	Arginine	151-159	neurotensin	Homo sapiens	275-287
16087676-3	2005	Using high resolution accurate mass analysis on an ion trap Fourier transform mass spectrometer, the post-translational modification was identified as arginine linked to the gamma-carboxyl of Glu via an isopeptide bond, and we named the newly identified peptide "arginylated neurotensin" (R-NT, N-(neurotensin-C5-4-yl)arginine).	Arginine	151-159	neurotensin	Homo sapiens	275-286
16140268-7	2005	These data demonstrate that Arg-214/215 are involved in CRM1-mediated STAT3 nuclear export and the regulation of STAT3 activity.	Arginine	28-31	signal transducer and activator of transcription 3	Homo sapiens	70-75
16140268-7	2005	These data demonstrate that Arg-214/215 are involved in CRM1-mediated STAT3 nuclear export and the regulation of STAT3 activity.	Arginine	28-31	signal transducer and activator of transcription 3	Homo sapiens	113-118
16140268-3	2005	A previous study demonstrated that STAT3 with Arg-214/215 mutations in the coiled-coil domain (R214A/R215A; STAT3 RA) failed to undergo nuclear translocation.	Arginine	46-49	signal transducer and activator of transcription 3	Homo sapiens	108-113
16105738-1	2005	Extensive structure-activity relationship studies utilizing a beta-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (3), led to identification of a series of novel MC-4R selective disulfide-constrained hexapeptide analogs including Ac-[hCys-His-D-Phe-Arg-Trp-Cys]-NH(2) (12).	Arginine	106-109	msh homeobox 2	Homo sapiens	67-70
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Arginine	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	161-164
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Arginine	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-169
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Arginine	19-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	170-174
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Arginine	105-108	coagulation factor II, thrombin	Homo sapiens	13-21
16230424-5	2005	We observed an increased risk of ESCC associated with the P53 Pro/Pro (OR, 1.83; 95% CI, 1.43-2.35; P &lt; 0.001) or MDM2 GG (OR, 1.49; 95% CI, 1.16-1.91; P = 0.002) genotype, compared with the P53 Arg/Arg or MDM2 TT genotype, respectively.	Arginine	198-201	tumor protein p53	Homo sapiens	58-61
16230424-5	2005	We observed an increased risk of ESCC associated with the P53 Pro/Pro (OR, 1.83; 95% CI, 1.43-2.35; P &lt; 0.001) or MDM2 GG (OR, 1.49; 95% CI, 1.16-1.91; P = 0.002) genotype, compared with the P53 Arg/Arg or MDM2 TT genotype, respectively.	Arginine	202-205	tumor protein p53	Homo sapiens	58-61
16221857-2	2005	Genomic sequences for the glutamate receptor 2 (GluR2) subunit of AMPA receptors and the GluR5 and GluR6 subunits of kainate receptors all encode a neutral glutamine (Q) residue within the channel pore that can be converted by RNA editing to a positively charged arginine (R).	Arginine	263-271	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	89-94
16087677-11	2005	Cleavage of the syndecan-1 fusion protein by thrombin occurred only at a control cleavage site (Arg downward arrowGly) introduced into the linker region connecting the ectodomain with the enhanced yellow fluorescent protein.	Arginine	96-99	coagulation factor II, thrombin	Homo sapiens	45-53
16100109-3	2005	We demonstrate that Y14 is phosphorylated at its repeated arginine/serine (RS) dipeptides, likely by SR protein-specific kinases.	Arginine	58-66	RNA binding motif protein 8A	Homo sapiens	20-23
16100109-7	2005	Moreover, we found that Y14 is possibly methylated at multiple arginine residues in the carboxyl-terminal domain and that methylation of Y14 was antagonized by phosphorylation of RS dipeptides.	Arginine	63-71	RNA binding motif protein 8A	Homo sapiens	24-27
16100109-7	2005	Moreover, we found that Y14 is possibly methylated at multiple arginine residues in the carboxyl-terminal domain and that methylation of Y14 was antagonized by phosphorylation of RS dipeptides.	Arginine	63-71	RNA binding motif protein 8A	Homo sapiens	137-140
15905205-2	2005	The codon 72 polymorphism has been proposed to alter the phenotype of TP53 mutations, and TP53 mutations have been reported to occur preferentially on the arginine allele.	Arginine	155-163	tumor protein p53	Homo sapiens	90-94
16220201-7	2005	(4) SNP and L-Arg induced a down-regulation of Bcl-2 and an up-regulation of Bax proteins in normal AMs, but did not induce the same change pattern in BLM AMs.	Arginine	12-17	BCL2, apoptosis regulator	Rattus norvegicus	47-52
15941784-4	2005	Pancreas perfusion studies showed that Sur1 null pancreata lacked glucagon secretory responses to hypoglycemia and to synergistic stimulation by arginine.	Arginine	145-153	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	39-43
16203772-1	2005	PURPOSE: The Arg/Pro polymorphism in codon 72 of p53 was recently associated with age of onset of colorectal cancer in Lynch syndrome.	Arginine	13-16	tumor protein p53	Homo sapiens	49-52
16162643-0	2005	Structure-sweetness relationship in egg white lysozyme: role of lysine and arginine residues on the elicitation of lysozyme sweetness.	Arginine	75-83	lysozyme	Homo sapiens	46-54
16162643-0	2005	Structure-sweetness relationship in egg white lysozyme: role of lysine and arginine residues on the elicitation of lysozyme sweetness.	Arginine	75-83	lysozyme	Homo sapiens	115-123
16162643-5	2005	Single alanine substitutions of arginine residues showed that three arginine residues, Arg14, Arg21, and Arg73, play significant roles in lysozyme sweetness, whereas Arg45, Arg68, Arg125 and chemical modification by 1,2-cyclohexanedione did not affect sweetness.	Arginine	32-40	lysozyme	Homo sapiens	138-146
16162643-5	2005	Single alanine substitutions of arginine residues showed that three arginine residues, Arg14, Arg21, and Arg73, play significant roles in lysozyme sweetness, whereas Arg45, Arg68, Arg125 and chemical modification by 1,2-cyclohexanedione did not affect sweetness.	Arginine	68-76	lysozyme	Homo sapiens	138-146
16179605-5	2005	We found that mutation of the conserved arginine at position 179 of the PLD1 PX domain to lysine or to alanine (R179A or R179K, respectively) disrupts PtdIns(3,4,5)P3 binding.	Arginine	40-48	phospholipase D1	Homo sapiens	72-76
16033814-6	2005	Inclusion of the arginine-glycine-aspartic but not the arginine-glycine-glutamic peptide to neutrophil cultures blocked uPA kringle-induced potentiation of proinflammatory responses, demonstrating that interactions between the KD and integrins were involved.	Arginine	17-25	plasminogen activator, urokinase	Homo sapiens	120-123
16150047-4	2005	To the C-terminal part of recombinant staphylokinase (r-SAK), which is a promising profibrinolytic agent, we assembled: (i) the Kringle 2 domain (K2) of tissue-type plasminogen activator (t-PA), containing a fibrin-specific binding site, (ii) the RGD sequence (Arg-Gly-Asp) for the prevention of platelet aggregation and (iii) the antithrombotic agent - hirudin.	Arginine	261-264	plasminogen activator, tissue type	Homo sapiens	153-186
16199549-1	2005	The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant.	Arginine	114-122	tumor protein p53	Homo sapiens	44-47
16199549-1	2005	The polymorphic variants at codon 72 of the p53 gene were shown to be functionally distinct in vitro, whereby the arginine (arg) variant induces apoptosis more efficiently than the proline (pro) variant.	Arginine	114-117	tumor protein p53	Homo sapiens	44-47
16054204-8	2005	The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03).	Arginine	8-16	tumor protein p53	Homo sapiens	70-73
16054204-8	2005	The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03).	Arginine	8-16	tumor protein p53	Homo sapiens	195-198
16252695-11	2005	This mutation results in the replacement of arginine by cystine at position 548 of ESR1 protein.	Arginine	44-52	estrogen receptor 1	Homo sapiens	83-87
16137573-2	2005	We previously found that L-arginine, the substrate for nitric oxide synthase, significantly increased utrophin level in muscle and targeted it to the sarcolemma.	Arginine	25-35	utrophin	Mus musculus	102-110
16202926-7	2005	Treatment with IL-1beta also inhibited the uptake of arginine, and glutamate but had no significant effect on the uptake of leucine, tryptophan, and ascorbate.	Arginine	53-61	interleukin 1 beta	Homo sapiens	15-23
16088915-4	2005	Molecular analysis of the COL2A1 gene revealed an A to G transition at nucleotide +79 of exon 41 that converted the codon for arginine at amino acid 792 to a codon for glycine (Arg792Gly).	Arginine	126-134	collagen type II alpha 1 chain	Homo sapiens	26-32
16027151-10	2005	Arg substitution of three unique acidic amino acids on the surface of FN1 eliminated polysialylation not only of a minimal Ig5-FN1 substrate but also of full-length NCAM.	Arginine	0-3	fibronectin 1	Homo sapiens	70-73
16027151-10	2005	Arg substitution of three unique acidic amino acids on the surface of FN1 eliminated polysialylation not only of a minimal Ig5-FN1 substrate but also of full-length NCAM.	Arginine	0-3	fibronectin 1	Homo sapiens	127-130
16321272-0	2005	[Proportion of proinsulin two minutes after arginine stimulation: a pilot study].	Arginine	44-52	insulin	Homo sapiens	15-25
16321272-14	2005	CONCLUSION: The PI/TI and PI/(TI + PI) values 2 minutes after arginine stimulation may be used as predictors for beta cell function in clinical practice.	Arginine	62-70	insulin	Homo sapiens	16-18
16321272-14	2005	CONCLUSION: The PI/TI and PI/(TI + PI) values 2 minutes after arginine stimulation may be used as predictors for beta cell function in clinical practice.	Arginine	62-70	insulin	Homo sapiens	26-28
16321272-14	2005	CONCLUSION: The PI/TI and PI/(TI + PI) values 2 minutes after arginine stimulation may be used as predictors for beta cell function in clinical practice.	Arginine	62-70	insulin	Homo sapiens	26-28
16024909-3	2005	Here we used a modeled structure of S. cerevisiae LTA4 hydrolase, mutational analysis, and binding studies to show that Glu-316 and Arg-627 are critical for catalysis, allowing us to a propose a mechanism for the epoxide hydrolase activity.	Arginine	132-135	leukotriene A4 hydrolase	Homo sapiens	50-64
16166320-2	2005	Recent studies have established that an Arg (wild-type) to Gly mutation at amino acid 482 in ABCG2 alters substrate specificity.	Arginine	40-43	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	93-98
16172238-1	2005	Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial.	Arginine	54-62	tumor protein p53	Homo sapiens	28-31
15993059-0	2005	L-arginine analogs as alternate substrates for nitric oxide synthase.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	47-68
15993059-1	2005	The L-arginine analogs, N(delta)-methyl-L-arginine (deltaMA) and L-canavanine, were used to probe the role of the N delta nitrogen of L-arginine in the reaction catalyzed by nitric oxide synthase (NOS).	Arginine	4-14	nitric oxide synthase 2	Homo sapiens	174-195
15993059-1	2005	The L-arginine analogs, N(delta)-methyl-L-arginine (deltaMA) and L-canavanine, were used to probe the role of the N delta nitrogen of L-arginine in the reaction catalyzed by nitric oxide synthase (NOS).	Arginine	40-50	nitric oxide synthase 2	Homo sapiens	174-195
16082224-1	2005	A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress.	Arginine	58-66	tumor protein p53	Homo sapiens	37-40
16172238-2	2005	We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects.	Arginine	176-184	tumor protein p53	Homo sapiens	48-51
16172238-2	2005	We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects.	Arginine	176-179	tumor protein p53	Homo sapiens	48-51
16172238-6	2005	Together, the data suggest that the expression of the different p53 polymorphs is selectively regulated in different ethnic populations, and that the arg allele is activated during cancer development in Asians.	Arginine	150-153	tumor protein p53	Homo sapiens	64-67
16140998-8	2005	CONCLUSIONS: The p53 codon 72 Arg/Pro polymorphism is not associated with age of onset or severity of glaucoma.	Arginine	30-33	tumor protein p53	Homo sapiens	17-20
16007417-11	2005	CONCLUSION: The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.	Arginine	16-19	tumor protein p53	Homo sapiens	65-68
16007417-11	2005	CONCLUSION: The Arg/Arg genotype of the Arg72Pro polymorphism in p53 is associated with increased likelihood of a bad outcome at discharge from the SICU.	Arginine	20-23	tumor protein p53	Homo sapiens	65-68
16140986-3	2005	Here, we performed a microarray analysis using Mef2c-null mouse embryos and identified a novel MEF2-regulated gene encoding a muscle-specific protein kinase, Srpk3, belonging to the serine arginine protein kinase (SRPK) family, which phosphorylates serine/arginine repeat-containing proteins.	Arginine	189-197	myocyte enhancer factor 2C	Mus musculus	95-99
15975930-11	2005	These data demonstrated that the proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for recognition and cleavage of von Willebrand factor between amino acid residues Asp(1595) and Arg(1668).	Arginine	229-232	von Willebrand factor	Homo sapiens	165-186
16187035-5	2005	RESULTS: We observed L-arginine localization in the internal limiting membrane (ILM), the ganglion cell layer (GCL), and the inner nuclear layer (INL).	Arginine	21-31	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	111-114
16187035-10	2005	CONCLUSION: NO might be produced in the GCL and amacrine cells, which show immunoreactivity to L-arginine, L-citrulline, and nNOS.	Arginine	95-105	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	40-43
16257919-6	2005	Finally, a mutation type (Arg--&gt;Ala at point 338) that can increase the clotting activity of hFIX as well as the potential application was briefly introduced.	Arginine	26-29	coagulation factor IX	Homo sapiens	96-100
15937333-3	2005	Here, we utilized "homology scanning" mutagenesis to identify beta tail mutants selectively defective in c-Src binding and found that amino acid exchanges affecting a combination of an Arg and Thr residue in the integrin beta3 tail control the binding specificity for SFKs but have no effect on talin binding.	Arginine	185-188	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-110
15937333-3	2005	Here, we utilized "homology scanning" mutagenesis to identify beta tail mutants selectively defective in c-Src binding and found that amino acid exchanges affecting a combination of an Arg and Thr residue in the integrin beta3 tail control the binding specificity for SFKs but have no effect on talin binding.	Arginine	185-188	integrin subunit beta 3	Homo sapiens	212-226
15819614-4	2005	The loss of immunoprecipitable eNOS from Cav-1-enriched fractions was accompanied by a decrease both in phosphorylation of eNOS and in enzymatic activity (conversion of arginine into citrulline).	Arginine	169-177	nitric oxide synthase 3	Homo sapiens	31-35
16109171-1	2005	BACKGROUND: A common sequence polymorphism at codon 72 of the p53 gene encoding either arginine or proline was recently shown to be functionally relevant for apoptosis induction in vitro.	Arginine	87-95	tumor protein p53	Homo sapiens	62-65
15998637-1	2005	Previous studies have suggested that thrombin interacts with integrins in endothelial cells through its RGD (Arg-187, Gly-188, Asp-189) sequence.	Arginine	109-112	coagulation factor II, thrombin	Homo sapiens	37-45
15819614-4	2005	The loss of immunoprecipitable eNOS from Cav-1-enriched fractions was accompanied by a decrease both in phosphorylation of eNOS and in enzymatic activity (conversion of arginine into citrulline).	Arginine	169-177	caveolin 1	Homo sapiens	41-46
15955813-2	2005	Herein we show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing factor 30 kDa (SPF30), and the Tudor domain-containing 3 (TDRD3) proteins interacted with arginine-glycine-rich motifs in a methylarginine-dependent manner.	Arginine	190-198	tudor domain containing 3	Homo sapiens	131-156
15853774-7	2005	The purified activated matriptase-3 serine protease domain expressed in insect cells hydrolysed synthetic peptide substrates, with a strong preference for Arg at position P(1), and showed proteolytic activity towards several macromolecular substrates, including gelatin, casein and albumin.	Arginine	155-158	transmembrane serine protease 7	Homo sapiens	23-35
15853774-7	2005	The purified activated matriptase-3 serine protease domain expressed in insect cells hydrolysed synthetic peptide substrates, with a strong preference for Arg at position P(1), and showed proteolytic activity towards several macromolecular substrates, including gelatin, casein and albumin.	Arginine	155-158	coagulation factor II, thrombin	Homo sapiens	36-51
16060669-3	2005	Disruption of the complementary interactions in this motif by mutation of F56 to serine, arginine, or glutamate is known to have deleterious effects on catalytic efficiency but remarkably different effects on the stability of the dimer [Hornby et al.	Arginine	89-97	DLEC1 cilia and flagella associated protein	Homo sapiens	74-77
15955813-2	2005	Herein we show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing factor 30 kDa (SPF30), and the Tudor domain-containing 3 (TDRD3) proteins interacted with arginine-glycine-rich motifs in a methylarginine-dependent manner.	Arginine	190-198	tudor domain containing 3	Homo sapiens	158-163
16086740-9	2005	While iNOS was only weakly expressed in the basal layer of the human epidermis, it was highly expressed in keratinocytes of the inner root sheath (IRS), where it colocalized with trichohyalin, a differentiation-associated protein of the IRS that requires enzyme-catalysed conversion of arginine to citrulline.	Arginine	286-294	nitric oxide synthase 2	Homo sapiens	6-10
16038634-7	2005	L-Arg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities.	Arginine	0-5	catalase	Rattus norvegicus	85-88
16061832-3	2005	Aim of this study was to evaluate the diagnostic cut-off limits of peak GH response to the GHRH-ARG test in overweight and obese as well as in lean population.	Arginine	96-99	growth hormone 1	Homo sapiens	72-74
16061832-3	2005	Aim of this study was to evaluate the diagnostic cut-off limits of peak GH response to the GHRH-ARG test in overweight and obese as well as in lean population.	Arginine	96-99	growth hormone releasing hormone	Homo sapiens	91-95
16061832-4	2005	DESIGN AND METHODS: The GH responses to the GHRH-ARG test were studied in 322 patients with organic hypothalamic-pituitary disease and in 318 control subjects.	Arginine	49-52	growth hormone 1	Homo sapiens	24-26
16061832-4	2005	DESIGN AND METHODS: The GH responses to the GHRH-ARG test were studied in 322 patients with organic hypothalamic-pituitary disease and in 318 control subjects.	Arginine	49-52	growth hormone releasing hormone	Homo sapiens	44-48
16061832-14	2005	CONCLUSIONS: In conclusion the GHRH-ARG test is a reliable tool for the diagnosis of adult GH deficiency in lean, overweight and obese patients, provided that specific BMI-related cut-off limits are assumed.	Arginine	36-39	growth hormone releasing hormone	Homo sapiens	31-35
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	108-111	insulin like growth factor 1	Homo sapiens	299-304
16012750-8	2005	We have demonstrated that L-Glutamine inhibited the activation of p70 S6 kinase and phosphorylation of 4E-BP1 induced by arginine or leucine in rat intestinal epithelial cells.	Arginine	121-129	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	103-109
16012769-2	2005	The inhibitory site of ATP on poly(ADP-ribose) polymerase-1 was identified by amino acid exchange mutation to be at the arginine 34 residue in the first Zn2+ finger.	Arginine	120-128	poly(ADP-ribose) polymerase 1	Homo sapiens	30-59
16041585-3	2005	The transmembrane regions of LILRC1 and LILRC2 contain an arginine residue, a common feature in receptors that associate with activating adaptor proteins.	Arginine	58-66	leukocyte immunoglobulin-like receptor, subfamily C, member 2	Rattus norvegicus	40-46
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	108-111	insulin like growth factor 1	Homo sapiens	410-415
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	299-304
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	410-415
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	299-304
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	410-415
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	299-304
16048565-1	2005	BACKGROUND AND AIMS: A specific mutation at codon 249 of the p53 tumor suppressor gene (guanine to thymine; arginine to serine [249(serine)p53]) is present in the cell-free plasma of 30-47% of patients with hepatocellular carcinoma (HCC) in regions with uniformly high levels of dietary exposure to the fungal toxin, aflatoxin B(1).	Arginine	108-116	tumor protein p53	Homo sapiens	61-64
16048565-1	2005	BACKGROUND AND AIMS: A specific mutation at codon 249 of the p53 tumor suppressor gene (guanine to thymine; arginine to serine [249(serine)p53]) is present in the cell-free plasma of 30-47% of patients with hepatocellular carcinoma (HCC) in regions with uniformly high levels of dietary exposure to the fungal toxin, aflatoxin B(1).	Arginine	108-116	tumor protein p53	Homo sapiens	139-142
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	410-415
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	299-304
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1	Homo sapiens	410-415
15941661-7	2005	TGF-beta1 codon 25 genotypes Arg/Pro and Pro/Pro were more common in patients with cirrhosis than in those without (23.6% vs. 7.4%, p = 0.005).	Arginine	29-32	transforming growth factor beta 1	Homo sapiens	0-9
15941661-9	2005	Logistic regression analysis identified male sex, age, serum ferritin and TGF-beta1 codon 25 Arg/Pro and Pro/Pro as independent predictors for the presence of cirrhosis.	Arginine	93-96	transforming growth factor beta 1	Homo sapiens	74-83
15941661-10	2005	The adjusted odds ratio for TGF-beta1 codon 25 Arg/Pro and Pro/Pro was 2.8 (95% CI 1.4-5.7, p = 0.004).	Arginine	47-50	transforming growth factor beta 1	Homo sapiens	28-37
15941661-11	2005	In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg.	Arginine	62-65	transforming growth factor beta 1	Homo sapiens	42-51
15941661-11	2005	In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg.	Arginine	144-147	transforming growth factor beta 1	Homo sapiens	42-51
15941661-11	2005	In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg.	Arginine	144-147	transforming growth factor beta 1	Homo sapiens	42-51
15970468-0	2005	Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase.	Arginine	13-21	uracil DNA glycosylase	Homo sapiens	42-64
16006504-3	2005	We show that impairing the conformational transition from zymogen to active proteinase that accompanies the formation of meizothrombin has no effect on initial cleavage at Arg-320 but inhibits subsequent cleavage at Arg-271.	Arginine	216-219	endogenous retrovirus group K member 25	Homo sapiens	76-86
16006504-5	2005	Irreversible stabilization of intact prothrombin in a proteinase-like state, even without prior cleavage at Arg-320, also enhanced cleavage at Arg-271.	Arginine	143-146	endogenous retrovirus group K member 25	Homo sapiens	54-64
15970468-0	2005	Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase.	Arginine	13-21	uracil DNA glycosylase	Homo sapiens	101-123
15949801-3	2005	Here, we have suggested the formation of an active site by structurally conserved residues in BH1 (glycine, arginine) and BH2 (tryptophan) domains of Bcl-2 family members, which also accounts for the functional effect of known mutations in BH1 (G145A, G145E) and BH2 (W188A) domains of Bcl-2.	Arginine	108-116	BCL2 apoptosis regulator	Homo sapiens	150-155
15894543-3	2005	We investigated the functionality of the Jak1 SH2 domain by stably reconstituting Jak1-defective human fibrosarcoma cells U4C with endogenous amounts of Jak1 in which the crucial arginine residue Arg466 within the SH2 domain has been replaced by lysine.	Arginine	179-187	Janus kinase 1	Homo sapiens	41-45
15949801-3	2005	Here, we have suggested the formation of an active site by structurally conserved residues in BH1 (glycine, arginine) and BH2 (tryptophan) domains of Bcl-2 family members, which also accounts for the functional effect of known mutations in BH1 (G145A, G145E) and BH2 (W188A) domains of Bcl-2.	Arginine	108-116	BCL2 apoptosis regulator	Homo sapiens	286-291
15976236-2	2005	L-arginine transport mediated by cationic amino acid transporters (including CAT-1, CAT-2, CAT-2A, and CAT-2B) is crucial in regulating iNOS activity.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	136-140
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Arginine	148-156	epidermal growth factor receptor	Homo sapiens	37-41
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	38-46	MRE11 homolog, double strand break repair nuclease	Homo sapiens	29-34
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	82-90	MRE11 homolog, double strand break repair nuclease	Homo sapiens	29-34
15970667-4	2005	Arginine methylation is required for the exonuclease activity of MRE11 and the intra-S phase DNA damage response.	Arginine	0-8	MRE11 homolog, double strand break repair nuclease	Homo sapiens	65-70
16013863-1	2005	The reactivity of arginine residues in model proteins (ubiquitin, cytochrome c, myoglobin, ribonuclease A, lysozyme) was examined using a selective tagging reaction in combination with on-line monitoring of the reaction progress by electrospray ionization mass spectrometry (ESI-MS).	Arginine	18-26	cytochrome c, somatic	Homo sapiens	66-78
16013863-1	2005	The reactivity of arginine residues in model proteins (ubiquitin, cytochrome c, myoglobin, ribonuclease A, lysozyme) was examined using a selective tagging reaction in combination with on-line monitoring of the reaction progress by electrospray ionization mass spectrometry (ESI-MS).	Arginine	18-26	lysozyme	Homo sapiens	107-115
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Arginine	148-156	epidermal growth factor receptor	Homo sapiens	51-55
16098254-4	2005	A second key polymorphism within the EGFR pathway (HER1 R497K) is a single nucleotide change (G-A) in codon 497 of the EGFR gene, which leads to an arginine-lysine substitution in the extracellular domain of subdomain IV.	Arginine	148-156	epidermal growth factor receptor	Homo sapiens	119-123
16165114-6	2005	By site directed mutagenesis we have mutated three conserved arginine residues (R294A, R307A, R316A) in the extracellular loop of P2X7 near the second transmembrane region.	Arginine	61-69	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	130-134
15941832-3	2005	HEXIM1, through its arginine-rich nuclear localization signal, directly associates with the ligand-binding domain of GR.	Arginine	20-28	HEXIM P-TEFb complex subunit 1	Homo sapiens	0-6
16009172-6	2005	MAIN OUTCOME MEASURE(S): Genotyping was performed by polymerase chain reaction-based amplification of the Arg and Pro variants at codon 72 of the p53 gene and by restriction fragment length polymorphism analysis of the G/G and G/A alleles in exon 4 of the ANGPT2 gene.	Arginine	106-109	tumor protein p53	Homo sapiens	146-149
15817634-5	2005	Critical glutamate, aspartate, lysine, arginine and histidine residues in ILs/ELs and TMs were detected that were essential for kNBC1-mediated Na(+)-dependent base transport.	Arginine	39-47	solute carrier family 4 member 4	Homo sapiens	128-133
15983231-6	2005	In conclusion, the common Arg allele of the PYY Arg72Thr variant modestly associates with type 2 diabetes and with type 2 diabetes-related quantitative traits.	Arginine	26-29	peptide YY	Homo sapiens	44-47
15939249-3	2005	It is derived from the amino acid L-arginine by the action of NO synthase (NOS).	Arginine	34-44	nitric oxide synthase 2	Homo sapiens	62-73
16120573-5	2005	A new coding polymorphism was detected in PON1 gene, which gives rise to amino acid substitutions of arginine (R) for glycine (G) at codon 160, whereas L54M polymorphism, which is common in white population, was not detected in our Han population.	Arginine	101-109	paraoxonase 1	Homo sapiens	42-46
15922518-1	2005	Arginine metabolism in macrophages during infection and inflammation is complex, owing to differential regulation of inducible nitric oxide synthase (iNOS) and arginases by cytokines and other agents.	Arginine	0-8	nitric oxide synthase 2, inducible	Mus musculus	117-148
15922518-1	2005	Arginine metabolism in macrophages during infection and inflammation is complex, owing to differential regulation of inducible nitric oxide synthase (iNOS) and arginases by cytokines and other agents.	Arginine	0-8	nitric oxide synthase 2, inducible	Mus musculus	150-154
15911102-0	2005	Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma.	Arginine	43-51	insulin	Homo sapiens	187-194
15911102-8	2005	High-dose insulin was included to induce a state of hypoaminoacidaemia to augment arginine depletion.	Arginine	82-90	insulin	Homo sapiens	10-17
15964996-0	2005	Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation.	Arginine	57-65	PPARG coactivator 1 alpha	Homo sapiens	43-53
15964996-2	2005	We report here that PGC-1alpha coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator.	Arginine	70-78	PPARG coactivator 1 alpha	Homo sapiens	20-30
15964996-3	2005	Mutation of three substrate arginines in the C-terminal region of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compromised the ability of PGC-1alpha to induce endogenous target genes.	Arginine	28-37	PPARG coactivator 1 alpha	Homo sapiens	66-76
15964996-3	2005	Mutation of three substrate arginines in the C-terminal region of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compromised the ability of PGC-1alpha to induce endogenous target genes.	Arginine	28-37	PPARG coactivator 1 alpha	Homo sapiens	127-137
15964996-3	2005	Mutation of three substrate arginines in the C-terminal region of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compromised the ability of PGC-1alpha to induce endogenous target genes.	Arginine	28-37	PPARG coactivator 1 alpha	Homo sapiens	127-137
15941832-3	2005	HEXIM1, through its arginine-rich nuclear localization signal, directly associates with the ligand-binding domain of GR.	Arginine	20-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	117-119
15778742-2	2005	GW274150 and GW273629 are arginine competitive, NADPH-dependent inhibitors of human iNOS with steady state K(d) values of &lt;40 and &lt;90 nM, respectively.	Arginine	26-34	nitric oxide synthase 2	Homo sapiens	84-88
15826948-8	2005	Third, we show that mutation of Arg(31) to Lys led to destabilization of STAT1 and STAT3, implicating an important structural role of Arg(31).	Arginine	32-35	signal transducer and activator of transcription 3	Homo sapiens	83-88
15826954-4	2005	We previously showed that mutations in amino acid residues Ser-181 and Met-182 in H3, Leu-219 and Leu-220 and Arg-226 in H5, Ileu-338 in H10, and Ileu-346 in H11, which line the LBD pocket in HNF-4alpha and come in contact with the ligand, impair its transactivation potential.	Arginine	110-113	hepatocyte nuclear factor 4 alpha	Homo sapiens	192-202
16158823-10	2005	We found overexpression of the p53 protein in lymphoid cells and a point missense mutation in codon 280 at exon 8 that changed AGA (Arg) to AGT (Ser).	Arginine	132-135	tumor protein p53	Homo sapiens	31-34
15899386-2	2005	TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations.	Arginine	65-73	tumor protein p53	Homo sapiens	0-4
15899386-2	2005	TP53 has two common polymorphic forms encoding either proline or arginine, at position 72, and the presence of homozygous arginine has been reported as a risk factor for cervical cancer in many populations.	Arginine	122-130	tumor protein p53	Homo sapiens	0-4
16158823-10	2005	We found overexpression of the p53 protein in lymphoid cells and a point missense mutation in codon 280 at exon 8 that changed AGA (Arg) to AGT (Ser).	Arginine	132-135	angiotensinogen	Homo sapiens	140-143
15878328-6	2005	These results, together, indicate that QBRICK is an adhesive ligand of basement membrane distinctively recognized by cells in the embryonic skin and hair follicles through different types of integrins directed to the Arg-Gly-Asp motif.	Arginine	217-220	Fras1 related extracellular matrix protein 1	Mus musculus	39-45
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Arginine	37-40	coagulation factor II thrombin receptor	Homo sapiens	49-53
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Arginine	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
15899857-8	2005	We also discovered enhancement of the ER-stressed induction of the Grp78 promoter through the interaction of YY1 with the arginine methyltransferase PRMT1 and evidence of its action through methylation of the arginine 3 residue on histone H4.	Arginine	122-130	heat shock protein family A (Hsp70) member 5	Homo sapiens	67-72
15899857-8	2005	We also discovered enhancement of the ER-stressed induction of the Grp78 promoter through the interaction of YY1 with the arginine methyltransferase PRMT1 and evidence of its action through methylation of the arginine 3 residue on histone H4.	Arginine	122-130	YY1 transcription factor	Homo sapiens	109-112
15894612-4	2005	Selective mutation of one of the basic TM residues of NKG2D resulted in loss of two DAP10 chains, indicating that each TM arginine serves as an interaction site for a DAP10 dimer.	Arginine	122-130	hematopoietic cell signal transducer	Homo sapiens	167-172
15654770-0	2005	Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).	Arginine	0-8	interleukin 2	Homo sapiens	31-35
15654770-0	2005	Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	64-100
15654770-0	2005	Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).	Arginine	0-8	protein arginine methyltransferase 5	Homo sapiens	102-107
15654770-3	2005	In the present study, we report a role for protein arginine methylation in regulating IL-2 (interleukin 2) gene expression in T lymphocytes.	Arginine	51-59	interleukin 2	Homo sapiens	86-90
15654770-3	2005	In the present study, we report a role for protein arginine methylation in regulating IL-2 (interleukin 2) gene expression in T lymphocytes.	Arginine	51-59	interleukin 2	Homo sapiens	92-105
15890278-3	2005	Using data from c-AMP assays in combination with structural analysis of melanocortin receptor/ligand models, we conclude that a lysine residue at the C-terminus of the His-Phe-Arg-Trp core sequence of melanocortin hormone is an important determinant for receptor selectivity in the both cyclic and linear MSH analogues.	Arginine	176-179	msh homeobox 2	Homo sapiens	305-308
15896001-6	2005	Reductive methylation of lysine residues or cyclohexanedione modification of arginine residues in apoE abolished its ability to inhibit LDL oxidation.	Arginine	77-85	apolipoprotein E	Homo sapiens	98-102
15865451-3	2005	A DDAH from Pseudomonas aeruginosa was cloned, and asymmetrically methylated arginine analogues were shown to be the preferred substrates, with ADMA displaying a slightly higher k(cat)/K(M) value than NMMA.	Arginine	77-85	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	2-6
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Arginine	217-220	complement C5a receptor 1	Homo sapiens	61-65
15826818-8	2005	In conclusion, eosinophils might exhibit differential modulation of the L-arginine/iNOS pathway depending on the profile of Th2 cytokines produced during allergic diseases.	Arginine	74-82	nitric oxide synthase 2	Rattus norvegicus	83-87
15826818-9	2005	IL-4 appears to be an important Th2 cytokine involved in the induction of the L-arginine/iNOS pathway in eosinophils.	Arginine	78-88	nitric oxide synthase 2	Rattus norvegicus	89-93
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Arginine	217-220	complement C5a receptor 1	Homo sapiens	61-64
15728581-4	2005	To elucidate the structural reasons for this specificity, we have crystallized recombinant human Arg(26)-cystatin D and solved its structures at room temperature and at cryo conditions to 2.5- and 1.8-A resolution, respectively.	Arginine	97-100	cystatin D	Homo sapiens	105-115
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Arginine	227-230	complement C5a receptor 1	Homo sapiens	61-65
15661745-2	2005	In this report we have mapped the ligand binding site on the C5aR using a series of agonist and antagonist peptide mimics of the C terminus of C5a as well as receptors mutated at putative interaction sites (Ile(116), Arg(175,) Arg(206), Glu(199), Asp(282), and Val(286)).	Arginine	227-230	complement C5a receptor 1	Homo sapiens	61-64
15661745-9	2005	Arg(206) and Arg(175) both appear to interact with the C-terminal carboxylate of C5a agonist peptides, suggesting a dynamic binding mechanism that may be a part of a receptor activation switch.	Arginine	0-3	complement C5a receptor 1	Homo sapiens	81-84
15746105-6	2005	Peptides encompassing these clustered acidic regions, residues 373-395 and 719-740, blocked thrombin cleavage of the isolated heavy chain at Arg(372) and Arg(740) and inhibited A2 binding to thrombin Ser(205) --&gt; Ala, suggesting that both A2 domain regions potentially support interaction with thrombin.	Arginine	141-144	coagulation factor II, thrombin	Homo sapiens	92-100
15746105-6	2005	Peptides encompassing these clustered acidic regions, residues 373-395 and 719-740, blocked thrombin cleavage of the isolated heavy chain at Arg(372) and Arg(740) and inhibited A2 binding to thrombin Ser(205) --&gt; Ala, suggesting that both A2 domain regions potentially support interaction with thrombin.	Arginine	154-157	coagulation factor II, thrombin	Homo sapiens	92-100
15661745-9	2005	Arg(206) and Arg(175) both appear to interact with the C-terminal carboxylate of C5a agonist peptides, suggesting a dynamic binding mechanism that may be a part of a receptor activation switch.	Arginine	13-16	complement C5a receptor 1	Homo sapiens	81-84
15746105-9	2005	These data suggest the acidic region comprising residues 389-394 in factor VIII A2 domain interacts with thrombin via its heparin-binding exosite and facilitates cleavage at Arg(740) during procofactor activation.	Arginine	174-177	coagulation factor II, thrombin	Homo sapiens	105-113
15853837-4	2005	Recent studies suggest that the GH releasing hormone + arginine (GHRH + ARG) test can identify GHD in cranially irradiated patients at longer time intervals after radiation.	Arginine	55-63	growth hormone releasing hormone	Homo sapiens	65-69
15892647-2	2005	Evidences for the islet dysfunction in type 2 diabetes are a)impaired insulin response to various challenges such as glucose, arginine and isoproterenol, b)defective dynamic of insulin secretion resulting in preferential reduction on first phase insulin secretion and irregular oscillations of plasma insulin and c)defective conversion of proinsulin to insulin leading to elevated proinsulin to insulin ratio.	Arginine	126-134	insulin	Homo sapiens	70-77
15942101-4	2005	Direct sequencing revealed that they all had missense mutation in codon 175 (G to A) of arginine switched to histidine, suggesting a germline mutation of TP53.	Arginine	88-96	tumor protein p53	Homo sapiens	154-158
15830184-6	2005	RESULTS: Membrane depolarisation of Sur1(-/-) islets by arginine or increased extracellular K(+), elevated [Ca(2+)](i) and augmented insulin secretion.	Arginine	56-64	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	36-40
15966238-0	2005	Arginine and proline alleles of the p53 gene are associated with different locations of gastric cancer.	Arginine	0-8	tumor protein p53	Homo sapiens	36-39
15766572-4	2005	Furthermore, we show that l-arginine at low levels of glucose significantly stimulates the release of insulin from these cells, compared to exposure to high concentration of glucose.	Arginine	26-36	insulin	Homo sapiens	102-109
15857387-4	2005	The integrin ligand peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) induced rapid (within 5 min) and robust increases in tyrosine phosphorylation of focal adhesion kinase, proline-rich tyrosine kinase 2 and Src family kinases.	Arginine	32-35	protein tyrosine kinase 2 beta	Rattus norvegicus	165-195
15840035-3	2005	METHODS: [(3)H]-L-arginine uptake was examined after incubation with 20 mg/mL recombinant human serum albumin (rHSA) in HK-2 PTEC monolayers.	Arginine	15-26	albumin	Homo sapiens	96-109
15902492-5	2005	We also demonstrated that replacement of specific lysine residues in histones H3 and H4 by arginine affected the complementation capacity of both the yeast gene (yELP3) and the chimeric yhELP3 in the elp3Deltastrain.	Arginine	91-99	Elongator subunit ELP3	Saccharomyces cerevisiae S288C	162-167
15853904-2	2005	HLA-A*6824 differs from A*680102 by a single nucleotide change at position 275 in exon 2, which results in a conservative amino acid substitution from lysine to arginine in the peptide-binding groove at codon 68.	Arginine	161-169	major histocompatibility complex, class I, A	Homo sapiens	0-5
15853910-4	2005	Compared with DRB1*010101, to which it is closest, the new variant is characterized by a new replacement mutation (G--&gt;T) at nucleotide position 202 of exon 2, resulting in the amino acid substitution Arg--&gt;Leu at position 72.	Arginine	204-207	major histocompatibility complex, class II, DR beta 1	Homo sapiens	14-18
15766572-5	2005	The arginine-induced insulin release is via the production of nitric oxide, since treatment with N(G)-nitro-l-arginine, an inhibitor of nitric oxide synthase, blocks insulin secretion induced by l-arginine.	Arginine	4-12	insulin	Homo sapiens	21-28
15766572-5	2005	The arginine-induced insulin release is via the production of nitric oxide, since treatment with N(G)-nitro-l-arginine, an inhibitor of nitric oxide synthase, blocks insulin secretion induced by l-arginine.	Arginine	108-118	insulin	Homo sapiens	21-28
15766572-6	2005	These results indicate that nitric oxide plays a role in l-arginine-stimulated insulin release in hepatocytes expressing the human insulin gene, and provides a new strategy to induce insulin secretion from engineered non-beta cells.	Arginine	57-67	insulin	Homo sapiens	79-86
15766572-6	2005	These results indicate that nitric oxide plays a role in l-arginine-stimulated insulin release in hepatocytes expressing the human insulin gene, and provides a new strategy to induce insulin secretion from engineered non-beta cells.	Arginine	57-67	insulin	Homo sapiens	131-138
15766572-6	2005	These results indicate that nitric oxide plays a role in l-arginine-stimulated insulin release in hepatocytes expressing the human insulin gene, and provides a new strategy to induce insulin secretion from engineered non-beta cells.	Arginine	57-67	insulin	Homo sapiens	131-138
15837926-4	2005	Unlike transferrin receptor, the protease domain of PSMA contains a binuclear zinc site, catalytic residues, and a proposed substrate-binding arginine patch.	Arginine	142-150	folate hydrolase 1	Homo sapiens	52-56
15708851-11	2005	Taken together with fluorescence quenching and cross-linking analysis, a looped-back model of apoE4 is proposed in lipid-bound state, including spherical lipoprotein particles, wherein residues Arg-61 and Glu-255 are proximal to one another.	Arginine	194-197	apolipoprotein E	Homo sapiens	94-99
16566136-5	2005	Thrombin is stabilized by L-arginine and DL-lysine more intensively than by other amino acids.	Arginine	26-36	coagulation factor II, thrombin	Homo sapiens	0-8
15811383-7	2005	This interaction appears to be mediated by the proline-arginine-rich domain (PRD) of Dyn2, as a GST-PRD fragment binds Cav1 while GST-Dyn2DeltaPRD does not.	Arginine	55-63	caveolin 1	Homo sapiens	119-123
15818326-15	2005	Low extracellular arginine may reflect influx of the amino acid into hepatocytes, resulting in formation of NO in the presence of inducible NO synthase or conversion to ornithine in the presence of arginase in the urea cycle.	Arginine	18-26	nitric oxide synthase 2	Homo sapiens	130-151
15644313-9	2005	Replacement of a single alanine residue in the pore of HCN1 (Ala-352) by an arginine residue present in HCN2 at equivalent position (Arg-405) induced HCN2-type chloride sensitivity in HCN1.	Arginine	133-136	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	104-108
15644313-9	2005	Replacement of a single alanine residue in the pore of HCN1 (Ala-352) by an arginine residue present in HCN2 at equivalent position (Arg-405) induced HCN2-type chloride sensitivity in HCN1.	Arginine	133-136	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	150-154
15777294-2	2005	Cellular uptake of L-arginine, modulated by the isozymes of type-2 cationic amino acid transporters (CAT), including CAT-2, CAT-2A and CAT-2B, has been reported to be a crucial factor in the regulation of iNOS activity.	Arginine	19-29	nitric oxide synthase 2	Rattus norvegicus	205-209
15814626-2	2005	An Arg/Pro polymorphism at codon 72 of the p53 gene alters the ability of the p53 protein to induce apoptosis, influences the behavior of mutant p53, decreases DNA repair capacity, and may be linked with an increased risk of lung cancer.	Arginine	3-6	tumor protein p53	Homo sapiens	43-46
15680475-7	2005	Under arginine- and GIP-infusion together, insulin concentrations increased progressively to 3005+/-1604 pmol/l (p&lt;0.01) without further decreasing in ghrelin concentrations (98.9% of baseline, p=0.575).	Arginine	6-14	insulin	Homo sapiens	43-50
15681296-8	2005	This significant risk was restricted to those subject carriers of Arg (R) and Leu (L) allele of the PON1 192 and 55 variants and was confirmed in multiple logistic regression analysis.	Arginine	66-69	paraoxonase 1	Homo sapiens	100-104
15547116-0	2005	The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice.	Arginine	47-55	nitric oxide synthase 2, inducible	Mus musculus	12-16
15547116-9	2005	Collectively, these data show that NOS2 is constitutively expressed in the kidney and remarkably functional as it affects renal blood flow and de novo arginine production under baseline conditions and is important for the increase in renal citrulline turnover during endotoxemia.	Arginine	151-159	nitric oxide synthase 2, inducible	Mus musculus	35-39
15527420-7	2005	Recombinant C1r-LP exhibits esterolytic activity against peptide thioesters with arginine at the P1 position, but its catalytic efficiency (kcat/K(m)) is lower than that of C1r and C1s.	Arginine	81-89	complement C1r	Homo sapiens	12-15
15814626-2	2005	An Arg/Pro polymorphism at codon 72 of the p53 gene alters the ability of the p53 protein to induce apoptosis, influences the behavior of mutant p53, decreases DNA repair capacity, and may be linked with an increased risk of lung cancer.	Arginine	3-6	tumor protein p53	Homo sapiens	78-81
15814626-2	2005	An Arg/Pro polymorphism at codon 72 of the p53 gene alters the ability of the p53 protein to induce apoptosis, influences the behavior of mutant p53, decreases DNA repair capacity, and may be linked with an increased risk of lung cancer.	Arginine	3-6	tumor protein p53	Homo sapiens	78-81
15807873-0	2005	Growth hormone response to arginine test distinguishes multiple system atrophy from Parkinson"s disease and idiopathic late-onset cerebellar ataxia.	Arginine	27-35	growth hormone 1	Homo sapiens	0-14
15814626-7	2005	p53 mutations were significantly (P = 0.01) associated with the number of codon 72 Pro alleles: Pro/Pro homozygotes, 17 of 26 (65%); Arg/Pro heterozygotes, 45 of 79 (57%); and Arg/Arg homozygotes, 31 of 77 (40%).	Arginine	133-136	tumor protein p53	Homo sapiens	0-3
15814626-7	2005	p53 mutations were significantly (P = 0.01) associated with the number of codon 72 Pro alleles: Pro/Pro homozygotes, 17 of 26 (65%); Arg/Pro heterozygotes, 45 of 79 (57%); and Arg/Arg homozygotes, 31 of 77 (40%).	Arginine	176-179	tumor protein p53	Homo sapiens	0-3
15814626-7	2005	p53 mutations were significantly (P = 0.01) associated with the number of codon 72 Pro alleles: Pro/Pro homozygotes, 17 of 26 (65%); Arg/Pro heterozygotes, 45 of 79 (57%); and Arg/Arg homozygotes, 31 of 77 (40%).	Arginine	176-179	tumor protein p53	Homo sapiens	0-3
15809017-2	2005	OBJECTIVE: The purpose of this study was to determine the dose of oral arginine that elicits an optimal GH response and to determine the time course of the response.	Arginine	71-79	growth hormone 1	Homo sapiens	104-106
15809017-0	2005	Growth hormone responses to varying doses of oral arginine.	Arginine	50-58	growth hormone 1	Homo sapiens	0-14
15809017-1	2005	UNLABELLED: Intravenous (IV) arginine invokes an increase in growth hormone (GH) concentrations, however, little is known about the impact of oral arginine ingestion on the GH response.	Arginine	29-37	growth hormone 1	Homo sapiens	61-75
15733152-1	2005	BACKGROUND: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS).	Arginine	68-78	nitric oxide synthase 2	Homo sapiens	98-109
15809017-1	2005	UNLABELLED: Intravenous (IV) arginine invokes an increase in growth hormone (GH) concentrations, however, little is known about the impact of oral arginine ingestion on the GH response.	Arginine	29-37	growth hormone 1	Homo sapiens	77-79
15736048-6	2005	In contrast, treatment with L-Arg reduced the delay of the lesion, the increment in COX-2 expression induced by Ibuprofen, and was able to maintain PGE2 levels similar to the control group after 14 days.	Arginine	28-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
15736048-7	2005	Additionally, the histological study showed that the healing effects of L-Arg might be associated with an increased angiogenesis and FGF-2 expression.	Arginine	72-77	fibroblast growth factor 2	Homo sapiens	133-138
15736048-10	2005	In conclusion, the coupling of L-Arg to Ibuprofen is an attractive alternative to Ibuprofen administration alone because it not only attenuates but also improves the evolution of chronic lesions through mechanisms that implicate endogenous PG and FGF-2-associated pathways, which allow an increase of angiogenesis process.	Arginine	31-36	fibroblast growth factor 2	Homo sapiens	247-252
15795423-7	2005	Results of the microarray analysis indicated that arginine supplementation increased adipose tissue expression of key genes responsible for fatty acid and glucose oxidation: NO synthase-1 (145%), heme oxygenase-3 (789%), AMP-activated protein kinase (123%), and peroxisome proliferator-activated receptor gamma coactivator-1alpha (500%).	Arginine	50-58	PPARG coactivator 1 alpha	Rattus norvegicus	262-329
15809017-9	2005	CONCLUSION: In conclusion, 5 and 9 g of oral arginine caused a significant GH response.	Arginine	45-53	growth hormone 1	Homo sapiens	75-77
15608028-6	2005	METHODS: Genotyping was performed by PCR-based amplification of the p53 Arg and Pro variants at codon 72 in 175 cases of IRM and 143 controls.	Arginine	72-75	tumor protein p53	Homo sapiens	68-71
15640399-0	2005	Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells.	Arginine	35-43	nitric oxide synthase 3	Homo sapiens	66-99
15761791-1	2005	L-arginine is the substrate for the enzyme nitric oxide synthase (NOS), which is responsible for the production of nitric oxide (NO), an endogenous messenger molecule involved in many of the processes associated with the development of atherosclerosis.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	43-64
15729383-5	2005	The SH3 domain in ARG was required for hyper-responsiveness to IL-3, but not for prolonged viability.	Arginine	18-21	interleukin 3	Mus musculus	63-67
16022383-5	2005	To gain insight into GluRdelta2"s mechanisms, we recently generated mice that express either a wild-type or a mutant GIuRdelta2 transgene, in which the conserved arginine in GluRdelta2"s N-terminal putative ligand-binding motif was disrupted.	Arginine	162-170	glutamate receptor, ionotropic, delta 2	Mus musculus	21-31
16022383-5	2005	To gain insight into GluRdelta2"s mechanisms, we recently generated mice that express either a wild-type or a mutant GIuRdelta2 transgene, in which the conserved arginine in GluRdelta2"s N-terminal putative ligand-binding motif was disrupted.	Arginine	162-170	glutamate receptor, ionotropic, delta 2	Mus musculus	174-184
15756275-6	2005	We conclude that arginine homozygosity at codon 72 of the p53 gene is associated with a significant increased breast cancer risk in Jewish high-risk population.	Arginine	17-25	tumor protein p53	Homo sapiens	58-61
15611080-8	2005	A PTHrP-based analog ([p-benzoylphenylalanine1, Ile5,Arg(11,13),Tyr36]PTHrP-(1-36)NH2), which selectively activates the G(s)/cAMP pathway without inducing PTH1R endocytosis, failed to stimulate ERK1/2 activity.	Arginine	53-56	parathyroid hormone 1 receptor	Homo sapiens	155-160
15611080-8	2005	A PTHrP-based analog ([p-benzoylphenylalanine1, Ile5,Arg(11,13),Tyr36]PTHrP-(1-36)NH2), which selectively activates the G(s)/cAMP pathway without inducing PTH1R endocytosis, failed to stimulate ERK1/2 activity.	Arginine	53-56	mitogen-activated protein kinase 3	Homo sapiens	194-200
15869001-2	2005	Trans-membrane L-arginine transportation mediated by type-2 cationic amino acid transporter (CAT-2) isozymes, including CAT-2, CAT-2A, and CAT-2B, is one of the crucial mechanisms that regulate NO biosynthesis by iNOS.	Arginine	15-25	nitric oxide synthase 2	Rattus norvegicus	213-217
15741314-5	2005	Our results suggest that arginine methylation regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.	Arginine	25-33	MRE11 homolog, double strand break repair nuclease	Homo sapiens	72-77
15743275-0	2005	Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport.	Arginine	68-76	nitric oxide synthase 3	Bos taurus	19-52
15743275-1	2005	eNOS (endothelial nitric oxide synthase) catalyses the conversion of L-arginine into L-citrulline and NO.	Arginine	69-79	nitric oxide synthase 3	Bos taurus	0-4
15743275-1	2005	eNOS (endothelial nitric oxide synthase) catalyses the conversion of L-arginine into L-citrulline and NO.	Arginine	69-79	nitric oxide synthase 3	Bos taurus	6-39
15743275-2	2005	Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS.	Arginine	253-263	nitric oxide synthase 3	Bos taurus	44-48
15743275-2	2005	Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS.	Arginine	253-263	nitric oxide synthase 3	Bos taurus	188-192
15743275-2	2005	Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS.	Arginine	253-263	nitric oxide synthase 3	Bos taurus	188-192
15743275-9	2005	Taken together, these data suggest that direct interaction of eNOS with CAT-1 enhances NO release by a mechanism not involving arginine transport.	Arginine	127-135	nitric oxide synthase 3	Bos taurus	62-66
15741314-0	2005	Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.	Arginine	0-8	MRE11 homolog, double strand break repair nuclease	Homo sapiens	24-29
15741314-2	2005	Herein we show that the MRE11 checkpoint protein is arginine methylated by PRMT1.	Arginine	52-60	MRE11 homolog, double strand break repair nuclease	Homo sapiens	24-29
15741314-3	2005	Mutation of the arginines within MRE11 severely impaired the exonuclease activity of MRE11 but did not influence its ability to form complexes with RAD50 and NBS1.	Arginine	16-25	MRE11 homolog, double strand break repair nuclease	Homo sapiens	33-38
15741314-3	2005	Mutation of the arginines within MRE11 severely impaired the exonuclease activity of MRE11 but did not influence its ability to form complexes with RAD50 and NBS1.	Arginine	16-25	MRE11 homolog, double strand break repair nuclease	Homo sapiens	85-90
15743186-3	2005	On the basis of these findings, we combined in the N/OFQ-NH(2) template the chemical modifications Arg(14)-Lys(15) and (pF)Phe(4) that increase the agonist potency with those conferring partial agonist (Phe(1)Psi(CH(2)NH)Gly(2)) or pure antagonist (Nphe(1)) properties.	Arginine	99-102	prepronociceptin	Homo sapiens	51-56
15748286-9	2005	CONCLUSION: The results indicate that endogenous arginase activity attenuates iNANC nerve-mediated airway relaxation by inhibition of NO generation, presumably by limiting L-arginine availability to nNOS.	Arginine	172-182	nitric oxide synthase, brain	Cavia porcellus	199-203
15822935-6	2005	In the present work, the character of the changes in structural properties and conformational stability of alpha-lactalbumin in the complex with poly-Lys(Arg) has been studied in detail by steady-state fluorescence, circular dichroism, and differential scanning calorimetry.	Arginine	154-157	lactalbumin alpha	Homo sapiens	107-124
15683683-8	2005	Moreover, l-arginine enhanced productions of both the latter produced TNF-alpha and PGE2 from burnt macrophages, and the expressions of TNF-alpha and COX-2 were improved significantly, while l-NMMA did reverse ways.	Arginine	10-20	tumor necrosis factor	Mus musculus	70-79
15683683-8	2005	Moreover, l-arginine enhanced productions of both the latter produced TNF-alpha and PGE2 from burnt macrophages, and the expressions of TNF-alpha and COX-2 were improved significantly, while l-NMMA did reverse ways.	Arginine	10-20	tumor necrosis factor	Mus musculus	136-145
15731048-7	2005	Arginine-specific gingipains (Rgp"s) strongly diminished the level of TNF-alpha on the cell surface as measured by flow cytometry, and this process was not accompanied by an increased concentration of soluble TNF-alpha in the culture medium.	Arginine	0-8	tumor necrosis factor	Homo sapiens	70-79
15613418-0	2005	Influence of body mass index and gender on growth hormone (GH) responses to GH-releasing hormone plus arginine and insulin tolerance tests.	Arginine	102-110	growth hormone 1	Homo sapiens	43-57
15711639-3	2005	In particular, IL13+2044GA is expected to result in the nonconservative replacement of arginine 130 (R130) with glutamine (Q).	Arginine	87-95	interleukin 13	Homo sapiens	15-19
15952410-1	2005	To verify if the entity of the peak GH responses to the GHRH+arginine (ARG) test is able to show different degree forms of GH deficiency (GHD), we linked these responses with the number of other anterior pituitary deficits.	Arginine	71-74	growth hormone releasing hormone	Homo sapiens	56-60
15813610-6	2005	This mutation, is the result of a guanine to adenine transition in codon 855 at position 2926 in exon 7 of the AR gene, which causes an alteration of the coding nucleotide triad from CGC to CAC, which subsequently causes the substitution from arginine to histidine in the amino acid sequence of the receptor protein molecule.	Arginine	243-251	androgen receptor	Homo sapiens	111-113
15822935-5	2005	Association of alpha-lactalbumin with histone or poly-Lys(Arg) essentially changes its properties.	Arginine	58-61	lactalbumin alpha	Homo sapiens	15-32
15822935-8	2005	Experiments with the poly-amino acids of various molecular masses demonstrated a direct proportionality between the number of alpha-lactalbumin molecules bound per poly-Lys(Arg) and the surface area of the poly-amino acid random coil.	Arginine	173-176	lactalbumin alpha	Homo sapiens	126-143
15822935-10	2005	The conformational state of alpha-lactalbumin in a complex with poly-Lys(Arg), named alpha-LActalbumin Modified by Poly-Amino acid (LAMPA), differs from all other alpha-lactalbumin states characterized to date, representing an apo-like (molten globule-like) state with substantially decreased affinity for calcium ion.	Arginine	73-76	lactalbumin alpha	Homo sapiens	28-45
15822935-10	2005	The conformational state of alpha-lactalbumin in a complex with poly-Lys(Arg), named alpha-LActalbumin Modified by Poly-Amino acid (LAMPA), differs from all other alpha-lactalbumin states characterized to date, representing an apo-like (molten globule-like) state with substantially decreased affinity for calcium ion.	Arginine	73-76	lactalbumin alpha	Homo sapiens	85-102
15822935-11	2005	The requirement for efficient conversion of alpha-lactalbumin to the LAMPA state is a poly-Lys(Arg) chain consisting of several tens of amino acid residues.	Arginine	95-98	lactalbumin alpha	Homo sapiens	44-61
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Arginine	157-160	parathyroid hormone	Rattus norvegicus	15-34
15856950-11	2005	The apoptosis intensity characterized by the increase in the content of DNA fragments in the culture medium and in the caspase 3 activity, was inversely proportional to the ARG dosage in the genome.	Arginine	173-176	caspase 3	Homo sapiens	119-128
15748976-1	2005	In many prokaryotic organisms, secretory proteins harboring a twin-arginine consensus motif are exported in a fully folded conformation via the twin-arginine translocation (Tat) pathway.	Arginine	67-75	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	173-176
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Arginine	157-160	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	130-135
15842938-2	2005	METHOD: Prepro-parathyroid hormone cDNA of SD rat was cloned from its genomic gene and mutated by overlap mutant PCR, introducing furin consensus sequences (Arg-Lys-Lys-Arg).	Arginine	169-172	parathyroid hormone	Rattus norvegicus	15-34
15709758-8	2005	However, the exchange rate of the Arg(5) NH proton of MST-2SS was about 100 times faster than that of MST(1-12), and the structure calculation of MST-2SS was not converged on account of the small number of NOEs, indicating that MST-2SS takes a more flexible structure.	Arginine	34-37	serine/threonine kinase 3	Homo sapiens	54-59
15709758-8	2005	However, the exchange rate of the Arg(5) NH proton of MST-2SS was about 100 times faster than that of MST(1-12), and the structure calculation of MST-2SS was not converged on account of the small number of NOEs, indicating that MST-2SS takes a more flexible structure.	Arginine	34-37	serine/threonine kinase 3	Homo sapiens	146-151
15740668-11	2005	A mutation of C to T was detected by sequencing at the nucleotide 1080 that converts the Arg codon (CGA) to the termination codon (TGA).	Arginine	89-92	chromogranin A	Homo sapiens	100-103
15542598-6	2005	We found that thrombin proteolyzed tau at multiple arginine and lysine sites.	Arginine	51-59	coagulation factor II, thrombin	Homo sapiens	14-22
15473865-10	2005	Deletion analysis of the rpS2 amino acid sequence identified a N-terminal Arg-Gly repeat as the methylation site.	Arginine	74-77	ribosomal protein S2	Homo sapiens	25-29
15572357-0	2005	The Met-196 -&gt; Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.	Arginine	18-21	tumor necrosis factor	Homo sapiens	90-99
15572357-0	2005	The Met-196 -&gt; Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.	Arginine	18-21	nuclear factor kappa B subunit 1	Homo sapiens	130-139
15710394-3	2005	This study revealed changes after L-arginine treatment of utrophin-associated proteins and the alpha7B integrin subunit in mdx mouse, a dystrophin-deficient animal model.	Arginine	34-44	dystrophin, muscular dystrophy	Mus musculus	136-146
15667282-2	2005	A subset of bacterial redox enzymes is exported as folded proteins on the Tat (twin-arginine transport) pathway.	Arginine	84-92	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	74-77
15494207-6	2005	Substitution of arginine for lysine at one putative site of sumoylation, lysine(551), blocked sumoylation of all Sp3 isoforms in vivo and led to a marginal increase in Sp3-mediated trans-activation in insect and mammalian cells.	Arginine	16-24	Sp3 transcription factor	Homo sapiens	113-116
15655515-7	2005	Active eNOS was detected by quantifying conversion of L-arginine to L-citrulline and by measuring NO released from endothelial cells using the fluorescent probe DAF-2 (20-96 h).eNOS promoter activity increased in response to isoflavone treatment (20 h).	Arginine	54-64	nitric oxide synthase 3	Homo sapiens	7-11
15655515-7	2005	Active eNOS was detected by quantifying conversion of L-arginine to L-citrulline and by measuring NO released from endothelial cells using the fluorescent probe DAF-2 (20-96 h).eNOS promoter activity increased in response to isoflavone treatment (20 h).	Arginine	54-64	nitric oxide synthase 3	Homo sapiens	177-181
15670731-3	2005	In this study, we have generated nine Arg-482 mutants (G, I, M, S, T, D, N, K, Y) of ABCG2, and expressed them in insect cells.	Arginine	38-41	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	85-90
15788120-10	2005	TNF-alpha levels in peritoneal lavage fluid were lower in the Arg group than in the control group on post-operative day 3.	Arginine	62-65	tumor necrosis factor	Rattus norvegicus	0-9
15494207-6	2005	Substitution of arginine for lysine at one putative site of sumoylation, lysine(551), blocked sumoylation of all Sp3 isoforms in vivo and led to a marginal increase in Sp3-mediated trans-activation in insect and mammalian cells.	Arginine	16-24	Sp3 transcription factor	Homo sapiens	168-171
15572035-1	2005	We screened for genes specifically expressed in the mesenchymes of developing hair follicles using representational differential analysis; one gene identified was MAEG, which encodes a protein consisting of five EGF-like repeats, a linker segment containing a cell-adhesive Arg-Gly-Asp (RGD) motif, and a MAM domain.	Arginine	274-277	EGF-like-domain, multiple 6	Mus musculus	163-167
15701790-1	2005	Btn2p, a novel cytosolic coiled-coil protein in Saccharomyces cerevisiae, was previously shown to interact with and to be necessary for the correct localization of Rhb1p, a regulator of arginine uptake, and Yif1p, a Golgi protein.	Arginine	186-194	putative GTPase RHB1	Saccharomyces cerevisiae S288C	164-169
15616821-10	2005	Finally, in the PST of females, L-arginine-derived ornithine may be a precursor for the renal production of L -glutamate and L-glutamine because high levels of AII, ornithine aminotransferase and glutamine synthetase are expressed in this nephron segment.	Arginine	32-42	glutamate-ammonia ligase (glutamine synthetase)	Mus musculus	196-216
15611345-11	2005	Low arginine also induced changes in the translational machinery, indicative of impaired signaling through the nutrient sensing kinase mammalian target of rapamycin.	Arginine	4-12	mechanistic target of rapamycin kinase	Homo sapiens	135-164
15887862-15	2005	IGF-I plasma levels were positively associated to peak GH during GHRH+arginine (r=0.4, p&lt;0.0005).	Arginine	70-78	insulin like growth factor 1	Homo sapiens	0-5
15714114-6	2005	Four of the five sunscreens tested directly inhibited the conversion of arginine to citrulline by inducible nitric oxide synthase (iNOS) in vitro.	Arginine	72-80	nitric oxide synthase 2	Homo sapiens	98-129
15714114-6	2005	Four of the five sunscreens tested directly inhibited the conversion of arginine to citrulline by inducible nitric oxide synthase (iNOS) in vitro.	Arginine	72-80	nitric oxide synthase 2	Homo sapiens	131-135
15736300-2	2005	The most frequently reported mutation, 229CGC&gt;TGC (R77C) in exon 3 of SGCA, results in the substitution of arginine by cysteine.	Arginine	110-118	sarcoglycan alpha	Homo sapiens	73-77
15631944-1	2005	Expression of inducible nitric oxide synthase (iNOS) is generally accompanied by a parallel upregulation in l-arginine transport which is dependent, at least in part, on the synthesis of new carrier proteins.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	14-45
15631944-1	2005	Expression of inducible nitric oxide synthase (iNOS) is generally accompanied by a parallel upregulation in l-arginine transport which is dependent, at least in part, on the synthesis of new carrier proteins.	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	47-51
15631944-2	2005	It is not clear however whether the induction of iNOS and its subsequent utilisation of l-arginine for NO synthesis contribute to the enhancement in l-arginine transport rates observed following induction of cells with pro-inflammatory mediators.	Arginine	149-159	nitric oxide synthase 2	Homo sapiens	49-53
15701846-2	2005	Recently, a polymorphic variant in the EGFR gene that leads to an arginine-to-lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified.	Arginine	66-74	epidermal growth factor receptor	Homo sapiens	39-43
15708125-9	2005	SNP (an NO donor) or L-arginine (substrate for eNOS) induced the expression of VE-cadherin with the increase of NO production.	Arginine	21-31	cadherin 5	Homo sapiens	79-90
15684035-4	2005	Using recombinant proteins, we found uPAR directly binds alpha5beta1 and rather than blocking, renders fibronectin (Fn) binding by alpha5beta1 Arg-Gly-Asp (RGD) resistant.	Arginine	143-146	fibronectin 1	Homo sapiens	116-118
15561099-7	2005	Expression of CAPON RNA increased in diaphragm muscle of normal and mdx mice after treatment with L-arginine, the NOS substrate.	Arginine	98-108	nitric oxide synthase 1 (neuronal) adaptor protein	Mus musculus	14-19
15659545-0	2005	The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.	Arginine	8-11	sorbin and SH3 domain containing 2	Homo sapiens	22-28
21166158-6	2005	The content of NO, ET-1 in I/R group in plasma and brain tissue increased, the ratio of NO/ET-1 decreased.	Arginine	29-30	endothelin 1	Rattus norvegicus	19-23
21166158-8	2005	After using L-Arg and BQ123, the ratio of NO/ET-1 in plasma and brain tissue increased, the brain injury lightened.	Arginine	12-17	endothelin 1	Rattus norvegicus	45-49
21166162-6	2005	The effect of Ang II on NOS expression was inhibited by L-arginine.	Arginine	56-66	angiotensinogen	Rattus norvegicus	14-20
15656623-12	2005	On the basis of these results, a third mechanism is proposed in which the amidine inactivators of iNOS bind as does substrate L-arginine, but because of the amidine methyl group, the heme peroxy intermediate cannot be protonated, thereby preventing its conversion to the heme oxo intermediate.	Arginine	126-136	nitric oxide synthase 2	Homo sapiens	98-102
15583690-7	2005	Thus, the present study revealed that (a) the Arg allele is associated with p53 mutations, (b) the Pro allele is preferentially lost in OSCCs associated with cigarette smoking and AQ chewing, while the frequency of Arg allele loss is increased with alcohol drinking, and (c) haploinsufficiency of p53 is in itself likely to contribute to tumour progression in Taiwanese OSCCs.	Arginine	46-49	tumor protein p53	Homo sapiens	76-79
15583690-7	2005	Thus, the present study revealed that (a) the Arg allele is associated with p53 mutations, (b) the Pro allele is preferentially lost in OSCCs associated with cigarette smoking and AQ chewing, while the frequency of Arg allele loss is increased with alcohol drinking, and (c) haploinsufficiency of p53 is in itself likely to contribute to tumour progression in Taiwanese OSCCs.	Arginine	215-218	tumor protein p53	Homo sapiens	297-300
15544852-10	2005	Since L-arginine, probably through NO stimulation, abolished both the anorexia and the serotonergic activation, it can be proposed that the NO system, either directly or indirectly, counteracts IL-1beta anorexia.	Arginine	6-16	interleukin 1 beta	Rattus norvegicus	194-202
15701846-8	2005	Combined analysis showed the highest risk for local recurrence was seen in patients who possessed both a HER-1 497 Arg allele and &lt;20 CA repeats (P = 0.05, log-rank test).	Arginine	115-118	epidermal growth factor receptor	Homo sapiens	105-110
15701846-2	2005	Recently, a polymorphic variant in the EGFR gene that leads to an arginine-to-lysine substitution in the extracellular domain at codon 497 within subdomain IV of EGFR has been identified.	Arginine	66-74	epidermal growth factor receptor	Homo sapiens	162-166
15701846-7	2005	We found that patients with HER-1 497 Arg/Arg genotype or lower number of CA repeats (both alleles &lt;20) tended to have a higher risk of local recurrence (P = 0.24 and 0.31, respectively).	Arginine	38-41	epidermal growth factor receptor	Homo sapiens	28-33
15701846-7	2005	We found that patients with HER-1 497 Arg/Arg genotype or lower number of CA repeats (both alleles &lt;20) tended to have a higher risk of local recurrence (P = 0.24 and 0.31, respectively).	Arginine	42-45	epidermal growth factor receptor	Homo sapiens	28-33
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	77-80	cytochrome p450 oxidoreductase	Homo sapiens	30-33
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	77-80	cytochrome p450 oxidoreductase	Homo sapiens	215-218
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	176-179	cytochrome p450 oxidoreductase	Homo sapiens	30-33
15869391-4	2005	This review describes structural aspects of methylation of histone lysine residues by two enzyme families with entirely different structural scaffolding (the SET proteins and Dot1p) and methylation of protein arginine residues by PRMTs.	Arginine	209-217	DOT1 like histone lysine methyltransferase	Homo sapiens	175-180
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	176-179	cytochrome p450 oxidoreductase	Homo sapiens	215-218
15567168-4	2005	In this study, we showed that l-glutamine inhibited the activation of p70 S6 kinase and phosphorylation of 4E-BP1 induced by arginine or leucine in rat intestinal epithelial cells.	Arginine	125-133	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	107-113
15367387-1	2005	Nitric oxide (NO) is synthesized from l-arginine by nitric oxide synthase (NOS), and nitrite and nitrate are believed to be waste forms of NO.	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	52-73
15565302-7	2005	In the two missense mutations, the strong basic residue arginine was substituted by serine or glycine in highly conserved components of the putative transmembrane domain of PTCH, and these mutations may therefore affect the conformation and function of the PTCH protein.	Arginine	56-64	patched 1	Homo sapiens	173-177
15565302-7	2005	In the two missense mutations, the strong basic residue arginine was substituted by serine or glycine in highly conserved components of the putative transmembrane domain of PTCH, and these mutations may therefore affect the conformation and function of the PTCH protein.	Arginine	56-64	patched 1	Homo sapiens	257-261
16309371-15	2005	These are close to amino acids that are important for the binding of heme to catalase, 44 (Val) and 72-75 (Arg, Val, Val, His).	Arginine	107-110	catalase	Homo sapiens	77-85
16289503-5	2005	The TP53 Arg/Arg codon 72 genotype was detected in 21.9% of ICSCC and in 18.2% of CIN3 but only in 6% of CIN1-2 and in 5.2% of controls (P&lt;0.05).	Arginine	9-12	tumor protein p53	Homo sapiens	4-8
16289503-5	2005	The TP53 Arg/Arg codon 72 genotype was detected in 21.9% of ICSCC and in 18.2% of CIN3 but only in 6% of CIN1-2 and in 5.2% of controls (P&lt;0.05).	Arginine	13-16	tumor protein p53	Homo sapiens	4-8
16289503-8	2005	We conclude that TP53 Arg/Arg codon 72 genotype is a relevant risk factor for invasive squamous cell carcinoma of the conjunctiva and for CIN3 in the Ugandan population.	Arginine	22-25	tumor protein p53	Homo sapiens	17-21
16289503-8	2005	We conclude that TP53 Arg/Arg codon 72 genotype is a relevant risk factor for invasive squamous cell carcinoma of the conjunctiva and for CIN3 in the Ugandan population.	Arginine	26-29	tumor protein p53	Homo sapiens	17-21
15620686-6	2005	The N-terminal arginine on RPPGF binds to the P2 position or proline46 on PAR4 to block thrombin cleavage.	Arginine	15-23	coagulation factor II, thrombin	Homo sapiens	88-96
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	106-114	nitric oxide synthase 2	Rattus norvegicus	243-247
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	116-121	nitric oxide synthase 2	Rattus norvegicus	243-247
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	195-200	nitric oxide synthase 2	Rattus norvegicus	243-247
15701046-1	2005	Synthesis of compounds containing a fragment similar to the guanidine group of L-arginine, which is a substrate of nitric oxide synthase (NOS), is the main direction in creating NOS inhibitors.	Arginine	79-89	nitric oxide synthase 2	Homo sapiens	115-136
15642159-2	2005	The A908G (Lys303--&gt;Arg) change in the gene encoding oestrogen receptor-alpha (ER-alpha) creates a hypersensitivity to oestradiol and would have significant consequences if present in breast carcinoma, especially those treated with endocrine therapy.	Arginine	23-26	estrogen receptor 1	Homo sapiens	82-90
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Arginine	16-19	tumor protein p53	Homo sapiens	78-81
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Arginine	20-23	tumor protein p53	Homo sapiens	78-81
16122882-1	2005	BACKGROUND: The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (HPV) infection and thus altering cancer risk.	Arginine	20-23	tumor protein p53	Homo sapiens	78-81
15616016-4	2005	A glucose-potentiated arginine test, performed only in insulin-independent transplant subjects (n = 5), demonstrated significant impairments in the glucose-potentiation slope (P &lt; 0.05) and the maximal response to arginine (AR(max); P &lt; 0.05), a measure of beta-cell secretory capacity.	Arginine	22-30	insulin	Homo sapiens	55-62
24790307-4	2005	Molecular analysis demonstrated that he was hemizygous for a G to C transversion in exon 2 of the AVPR2 gene which resulted in a glycine to arginine substitution (G107R) at the 107th codon of the first extracellular loop.	Arginine	140-148	arginine vasopressin receptor 2	Homo sapiens	98-103
15616016-4	2005	A glucose-potentiated arginine test, performed only in insulin-independent transplant subjects (n = 5), demonstrated significant impairments in the glucose-potentiation slope (P &lt; 0.05) and the maximal response to arginine (AR(max); P &lt; 0.05), a measure of beta-cell secretory capacity.	Arginine	217-225	insulin	Homo sapiens	55-62
15638817-5	2005	RESULTS: After 3 weeks of treatment, values of SBP, DPB and MAP were significantly lower in the group taking l-arginine as compared with the placebo group (SBP: 134.2 +/- 2.9 vs. 143.1 +/- 2.8; DBP: 81.6 +/- 1.7 vs. 86.5 +/- 0.9; MAP: 101.8 +/- 1.5 vs. 108.0 +/- 1.2 mmHg, P &lt; 0.01).	Arginine	109-119	D-box binding PAR bZIP transcription factor	Homo sapiens	194-197
15593299-4	2005	In HA-1, a protein of unknown function, a His/Arg polymorphism (His168Arg), which constitutes the immunologic target for HA-1-specific cytotoxic T cells, has been causatively linked to graft-versus-host disease after allogeneic stem cell transplantation.	Arginine	46-49	Rho GTPase activating protein 45	Homo sapiens	121-125
15663510-8	2005	DNA sequencing in all the affected individuals disclosed a heterozygous G--&gt;C substitution at nucleotide 173 of the fumarate hydratase gene, that converts an arginine residue (CGA) to proline (CCA).	Arginine	161-169	chromogranin A	Homo sapiens	179-182
15732191-9	2005	Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003.	Arginine	15-23	tumor protein p53	Homo sapiens	71-74
15593299-4	2005	In HA-1, a protein of unknown function, a His/Arg polymorphism (His168Arg), which constitutes the immunologic target for HA-1-specific cytotoxic T cells, has been causatively linked to graft-versus-host disease after allogeneic stem cell transplantation.	Arginine	46-49	Rho GTPase activating protein 45	Homo sapiens	3-7
15732191-9	2005	Replacement of arginine (Arg) by proline (Pro) at position 72 of human p53 decreases its apoptotic potential [Dumont et al., 2003.	Arginine	25-28	tumor protein p53	Homo sapiens	71-74
15732191-14	2005	Using a formal meta-analysis of the published literature we show that carriers of the TP53 codon 72 Pro/Pro genotype have an increased cancer risk compared to Arg/Arg carriers (p&lt;0.05).	Arginine	159-162	tumor protein p53	Homo sapiens	86-90
15732191-14	2005	Using a formal meta-analysis of the published literature we show that carriers of the TP53 codon 72 Pro/Pro genotype have an increased cancer risk compared to Arg/Arg carriers (p&lt;0.05).	Arginine	163-166	tumor protein p53	Homo sapiens	86-90
17252985-6	2005	Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock.	Arginine	86-89	proopiomelanocortin	Homo sapiens	23-42
17252985-6	2005	Melanocortin peptides, proopiomelanocortin (POMC)-derived peptides which have His-Phe-Arg-Trp sequence, are secreted in large amounts in the sympathoinhibitory phase of cardiovascular regulation in shock.	Arginine	86-89	proopiomelanocortin	Homo sapiens	44-48
16351563-0	2005	L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. We examined the effect of dietary supplementation with L-arginine on breath condensate VEGF, exhaled nitric oxide (NO), plasma erythropoietin, symptoms of acute mountain sickness, and respiratory related sensations at 4,342 m through the course of 24 h in seven healthy male subjects.	Arginine	0-10	vascular endothelial growth factor A	Homo sapiens	66-70
15886745-9	2005	Regarding the study of angiogenesis the following have been described: a. antibodies targeting VEGF, labeled with radionuclides emitting beta- and/or gamma-radiation, which can be applied for the diagnosis and possibly, for the treatment of cancer, b. peptide derivatives which contain the amino-acid sequence RGD (Arg-Gly-Asp) and compete for the alpha(nu)beta(3) integrins, with the proteins of the stroma.	Arginine	315-318	vascular endothelial growth factor A	Homo sapiens	95-99
15921163-0	2005	A novel mutation of the alpha2-globin causing alpha(+)-thalassemia: Hb Plasencia [alpha125(H8)Leu--Arg (alpha2).	Arginine	99-102	glycoprotein hormone subunit alpha 2	Homo sapiens	24-30
16351563-0	2005	L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. We examined the effect of dietary supplementation with L-arginine on breath condensate VEGF, exhaled nitric oxide (NO), plasma erythropoietin, symptoms of acute mountain sickness, and respiratory related sensations at 4,342 m through the course of 24 h in seven healthy male subjects.	Arginine	0-10	erythropoietin	Homo sapiens	224-238
15921163-3	2005	The resulting variant, which causes a nondeletional alpha-thal, was named Hb Plasencia [alpha125(H8)Leu --> Arg (alpha2)] after the place of residence of the affected family.	Arginine	108-111	glycoprotein hormone subunit alpha 2	Homo sapiens	113-119
16351563-4	2005	There was a trend (p = 0.087) toward greater exhaled NO and significant increases in breath condensate VEGF with L-arginine treatment, but no L-arginine effect on serum EPO.	Arginine	113-123	vascular endothelial growth factor A	Homo sapiens	103-107
16351563-5	2005	These results suggest that L-arginine supplementation increases HIF-1 stabilization in the lung, possibly through a NO-dependent pathway.	Arginine	27-37	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Arginine	128-136	matrix metallopeptidase 3	Homo sapiens	238-243
15389544-11	2005	These results suggest that abnormalities in cell signalling or in arginine and glutamine metabolism in macrophages of obese rats, resulting in decreased TNFalpha production and increased NO release, may contribute to increased susceptibility to infection in insulin-resistant states.	Arginine	66-74	tumor necrosis factor	Rattus norvegicus	153-161
15623478-1	2005	BACKGROUND: The predictive value of codon 72 arginine homozygosity at the p53 gene for human papilloma virus associated cervical cancer risk remains inconclusive.	Arginine	45-53	tumor protein p53	Homo sapiens	74-77
15623478-7	2005	The p53 codon 72 arginine homozygous genotype was significantly over represented in patients compared with controls.	Arginine	17-25	tumor protein p53	Homo sapiens	4-7
15623478-10	2005	CONCLUSION: p53 codon 72 arginine homozygotes appear to be at greater risk of developing squamous cell carcinoma of the uterine cervix.	Arginine	25-33	tumor protein p53	Homo sapiens	12-15
16012186-3	2005	Careful perusal of these interacting regions shows the presence of a phosphorylated serine (pS397) and adjacent glutamates (EE404-405) in the D1 receptor, whereas NR1-1 contains three adjacent Arg residues (RRR893-896).	Arginine	193-196	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	163-168
16613374-2	2005	It is generated from arginine through the action of the enzyme nitric oxide synthase (NOS).	Arginine	21-29	nitric oxide synthase 2	Homo sapiens	63-84
15686539-4	2005	Further studies also demonstrated the presence of beta-Ala in other Fmoc-amino acids, particularly in Fmoc-Arg(Pbf)-OH.	Arginine	107-110	PTTG1 interacting protein	Homo sapiens	111-114
16302680-7	2005	In conclusion, our finding suggests the functional p53 codon 72 polymorphism may be associated with SLE susceptibility, suggesting individuals who carry the Pro allele may have a higher risk to SLE susceptibility than those with the Arg allele.	Arginine	233-236	tumor protein p53	Homo sapiens	51-54
15492754-2	2005	The mi mutant allele encodes an abnormal MITF, in which one out of four consecutive arginines is deleted in the basic domain.	Arginine	84-93	melanogenesis associated transcription factor	Mus musculus	41-45
16020977-1	2005	OBJECTIVE: Nitric oxide (NO) is a product of L-arginine to L-citrulline conversion by nitric oxide synthase (NOS).	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	86-107
15864123-14	2005	This preliminary study points to the possibility that patients homozygous for glycine at the 990 position in exon 7 of the CaSR may be more sensitive to the calcimimetic drug cinacalcet compared to those who are homozygous for arginine at that location.	Arginine	227-235	calcium sensing receptor	Homo sapiens	123-127
16293985-6	2005	However, the complete loss of thrombin-induced VEGF production upon treatment with argatroban, a derivative of arginine and a potent anticoagulant/antithrombin agent, supports the notion that argatroban serves as a useful therapeutic tool for thrombin-associated pathologic conditions.	Arginine	111-119	coagulation factor II, thrombin	Homo sapiens	30-38
16293985-6	2005	However, the complete loss of thrombin-induced VEGF production upon treatment with argatroban, a derivative of arginine and a potent anticoagulant/antithrombin agent, supports the notion that argatroban serves as a useful therapeutic tool for thrombin-associated pathologic conditions.	Arginine	111-119	vascular endothelial growth factor A	Homo sapiens	47-51
16106344-1	2005	The arginine repressor (ArgR) from Escherichia coli regulates genes for L-arginine metabolism and is a required recombination factor for colE1 plasmid replication.	Arginine	72-82	arginine repressor	Escherichia coli	4-22
15608118-7	2005	However, small but significant differences are observed; in contrast to the minor groove recognition of TRF1, in which an arginine residue recognizes the TT sequence, a lysine residue of TRF2 interacts with the TT part.	Arginine	122-130	telomeric repeat binding factor 1	Homo sapiens	104-108
16786747-0	2005	[The total antioxidative activity measured by FRAP method in women with intrauterine growth restriction treated by L-arginine].	Arginine	115-125	mechanistic target of rapamycin kinase	Homo sapiens	46-50
16106344-1	2005	The arginine repressor (ArgR) from Escherichia coli regulates genes for L-arginine metabolism and is a required recombination factor for colE1 plasmid replication.	Arginine	72-82	arginine repressor	Escherichia coli	24-28
16106344-4	2005	In agreement with X-ray diffraction studies, it is shown that ArgR oligomerizes to form hexamers in both the presence and absence of L-arginine, and the basic unit of oligomerization appears to be the trimer.	Arginine	133-143	arginine repressor	Escherichia coli	62-66
15501822-6	2004	Activation of beta-arrestin 2 upon V(2)R-pp binding involves the release of its C terminus, as indicated by exposure of a previously inaccessible cleavage site, one of the polar core residues Arg(394), and rearrangement of its N terminus, as indicated by the shielding of a previously accessible cleavage site, residue Arg(8).	Arginine	319-322	arrestin beta 2	Homo sapiens	14-29
15485890-2	2004	The binding of the abundant extracellular matrix ligand fibronectin to integrins alpha(5)beta(1) and alpha(v)beta(3) is known to depend upon the Arg-Gly-Asp (RGD) motif on the tenth fibronectin FIII domain.	Arginine	145-148	fibronectin 1	Homo sapiens	56-67
15485890-2	2004	The binding of the abundant extracellular matrix ligand fibronectin to integrins alpha(5)beta(1) and alpha(v)beta(3) is known to depend upon the Arg-Gly-Asp (RGD) motif on the tenth fibronectin FIII domain.	Arginine	145-148	fibronectin 1	Homo sapiens	182-193
15501822-6	2004	Activation of beta-arrestin 2 upon V(2)R-pp binding involves the release of its C terminus, as indicated by exposure of a previously inaccessible cleavage site, one of the polar core residues Arg(394), and rearrangement of its N terminus, as indicated by the shielding of a previously accessible cleavage site, residue Arg(8).	Arginine	192-195	arrestin beta 2	Homo sapiens	14-29
15491978-10	2004	Pretreatment with the PKC inhibitor bisindolylmaleimide I prevented the reduction by PMA of both hCAT-1.EGFP-induced arginine transport and the internalization of the transporter.	Arginine	117-125	proline rich transmembrane protein 2	Homo sapiens	22-25
15585582-4	2004	One of these, KG-501 (2-naphthol-AS-E-phosphate), targeted a surface distal to the CREB binding groove that includes Arg-600, a residue that is required for the CREB:CBP interaction.	Arginine	117-120	CREB binding protein	Homo sapiens	166-169
15222879-6	2004	In the present study, we demonstrate that SMN binds to the arginine-rich N-terminus of FGF-2(23).	Arginine	59-67	fibroblast growth factor 2	Homo sapiens	87-92
15518912-2	2004	We previously reported that the replacement of Lys by Arg, and Met by Leu in VIP (IK312532; [Arg15, 20, 21, Leu17]-VIP) resulted in a significant improvement in metabolic stability and biological activity.	Arginine	54-57	vasoactive intestinal peptide	Rattus norvegicus	77-80
15844595-1	2005	OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar.	Arginine	103-111	tumor protein p53	Homo sapiens	81-84
15844595-1	2005	OBJECTIVE: To investigate the codon-72 polymorphism of the tumor suppressor gene p53, codon-72 encodes arginine (Arg) or proline (Pro) for a genetic predisposition,to keloid or hypertrophic scar.	Arginine	113-116	tumor protein p53	Homo sapiens	81-84
15688321-7	2004	The only specific inhibitor for human somatic ACE (sACE) was BPP9a, which is instable in the N-sACE-BPP9a complex due to repulsive electrostatic interactions between Arg P4-Arg 412 residues.	Arginine	166-169	angiotensin I converting enzyme	Homo sapiens	46-49
15688321-7	2004	The only specific inhibitor for human somatic ACE (sACE) was BPP9a, which is instable in the N-sACE-BPP9a complex due to repulsive electrostatic interactions between Arg P4-Arg 412 residues.	Arginine	173-176	angiotensin I converting enzyme	Homo sapiens	46-49
15604266-6	2004	These arginines were also required for endostatin to inhibit fibroblast growth factor-2- and vascular endothelial growth factor-A-induced chemotaxis of primary endothelial cells.	Arginine	6-15	vascular endothelial growth factor A	Homo sapiens	93-129
15569838-1	2004	BACKGROUND: Arginase competes with endothelial nitric oxide synthase (eNOS) for the substrate l-arginine and decreases NO production.	Arginine	94-104	nitric oxide synthase 3	Homo sapiens	35-68
15569838-8	2004	Interestingly, l-arginine (1 mmol/L), despite a significantly higher eNOS expression in aortas of apoE-/- mice, evoked a more pronounced contraction, which was reverted to a greater vasodilation by the arginase inhibitor l-norvaline (20 mmol/L) compared with the wild-type animals (n=5, P&lt;0.001).	Arginine	15-25	apolipoprotein E	Mus musculus	98-102
15568807-0	2004	High-resolution X-ray structure of the unexpectedly stable dimer of the [Lys(-2)-Arg(-1)-des(17-21)]endothelin-1 peptide.	Arginine	81-84	endothelin 1	Homo sapiens	100-112
15530866-0	2004	MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1).	Arginine	22-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	160-164
15596759-11	2004	Interestingly, hypoPP is caused by both mutations affecting nearby codons as well as the change of an arginine into another amino acid.	Arginine	102-110	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	15-21
15351781-4	2004	In a model of the rhodopsin-arrestin complex, the phosphates point in the direction of arrestin and form a continuous negatively charged surface, which is stabilized by a number of positively charged lysine and arginine residues of arrestin.	Arginine	211-219	rhodopsin	Homo sapiens	18-27
15282190-1	2004	The inducible form of nitric oxide synthase (NOS2) catalyzes the synthesis of nitric oxide (NO) from arginine in response to injury and infection.	Arginine	101-109	nitric oxide synthase 2, inducible	Mus musculus	45-49
15448144-0	2004	Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.	Arginine	0-8	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	45-48
15448144-0	2004	Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.	Arginine	0-8	plasminogen activator, tissue type	Homo sapiens	73-106
15448144-6	2004	Here, we show that tPA forms a direct complex with the amino-terminal domain (ATD) of the NR1 subunit of the NMDA receptor and cleaves this subunit at the arginine 260.	Arginine	155-163	plasminogen activator, tissue type	Homo sapiens	19-22
15448144-6	2004	Here, we show that tPA forms a direct complex with the amino-terminal domain (ATD) of the NR1 subunit of the NMDA receptor and cleaves this subunit at the arginine 260.	Arginine	155-163	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	90-93
15448144-7	2004	Furthermore, point mutation analyses show that arginine 260 is necessary for both tPA-induced cleavage of the ATD of NR1 and tPA-induced potentiation of NMDA receptor signaling.	Arginine	47-55	plasminogen activator, tissue type	Homo sapiens	82-85
15448144-7	2004	Furthermore, point mutation analyses show that arginine 260 is necessary for both tPA-induced cleavage of the ATD of NR1 and tPA-induced potentiation of NMDA receptor signaling.	Arginine	47-55	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	117-120
15448144-7	2004	Furthermore, point mutation analyses show that arginine 260 is necessary for both tPA-induced cleavage of the ATD of NR1 and tPA-induced potentiation of NMDA receptor signaling.	Arginine	47-55	plasminogen activator, tissue type	Homo sapiens	125-128
15561914-6	2004	The arginine-stimulated PI/C-peptide ratio decreased in the diabetic subjects from 4.4 +/- 1.5% before to 1.8 +/- 0.5% after the clamp (P &lt; 0.01).	Arginine	4-12	insulin	Homo sapiens	24-26
15571600-2	2004	We examined exon 28 of the von Willebrand factor gene in a patient with both von Willebrand"s disease and recurrent bleeding from angiodysplasia in the duodenum as well as his father"s, and found a point mutation, C 3916--&gt;T (amino acid substitution; Arg 543--&gt;Trp), in the A1 domain of the von Willebrand factor gene.	Arginine	254-257	von Willebrand factor	Homo sapiens	27-48
15704254-0	2004	L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice.	Arginine	0-10	apolipoprotein E	Mus musculus	44-48
15704254-0	2004	L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	52-56
15704254-1	2004	Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size.	Arginine	33-43	apolipoprotein E	Mus musculus	70-74
15704254-1	2004	Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size.	Arginine	33-43	nitric oxide synthase 2, inducible	Mus musculus	78-82
15704254-1	2004	Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size.	Arginine	45-50	apolipoprotein E	Mus musculus	70-74
15704254-1	2004	Previous studies have shown that L-arginine (L-Arg) administration to apoE-/-/iNOS-/- double knockout mice (dKO) on a Western diet paradoxically results in an increase in atherosclerotic lesion size.	Arginine	45-50	nitric oxide synthase 2, inducible	Mus musculus	78-82
15578956-8	2004	For example, platelet aggregation inhibitors, which interfere in the interactions between fibrinogen and its receptor, the glycoprotein IIb/IIIa complex, show extreme structural diversity but they share the common functional site of Arg-Gly-Asp (RGD) tripeptide segment.	Arginine	233-236	fibrinogen beta chain	Homo sapiens	90-100
15547693-8	2004	DNA sequencing in FaDu cells showed a G/T point mutation at codon 248 in exon 7 of p53 gene, resulting in an arginine-to-leucine substitution.	Arginine	109-117	tumor protein p53	Homo sapiens	83-86
15548746-7	2004	p5cdh mutants were hypersensitive toward Pro and other molecules producing P5C, such as Arg and Orn.	Arginine	88-91	aldehyde dehydrogenase 4 family member A1	Homo sapiens	0-5
15801262-4	2004	Nitric oxide (NO) is a free radical synthesized from L-arginine by one of the family of nitric oxide synthase (NOS) enzymes.	Arginine	53-63	nitric oxide synthase 2	Homo sapiens	88-109
15365822-2	2004	A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer.	Arginine	140-148	tumor protein p53	Homo sapiens	52-55
15365822-2	2004	A recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in the malignant transformation of colorectal adenoma to cancer.	Arginine	140-148	tumor protein p53	Homo sapiens	179-182
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Arginine	156-159	tumor protein p53	Homo sapiens	83-86
15378693-5	2004	Additionally, a minor derivative of the haptoglobin alpha2 chain carrying both modifications, deamidation at position five and the C-terminal arginine residue, was identified.	Arginine	142-150	haptoglobin	Homo sapiens	40-51
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Arginine	156-159	tumor protein p53	Homo sapiens	235-238
15364944-0	2004	Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein U	Homo sapiens	24-52
15347649-1	2004	The Tat protein export system serves to export folded proteins harboring an N-terminal twin arginine signal peptide across the cytoplasmic membrane.	Arginine	92-100	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	4-7
15339922-2	2004	Co-crystal structures of the core catalytic domain of human uracil-DNA glycosylase in complex with uracil-containing DNA suggested that arginine 276 in the highly conserved leucine intercalation loop may be important to enzyme interactions with DNA.	Arginine	136-144	uracil DNA glycosylase	Homo sapiens	60-82
15339922-8	2004	Using a concatemeric [(32)P]U.A DNA polynucleotide substrate to assess enzyme processivity, human uracil-DNA glycosylase was shown to use a processive search mechanism to locate successive uracil residues, and Arg(276) mutations did not alter this attribute.	Arginine	210-213	uracil DNA glycosylase	Homo sapiens	98-120
15604045-3	2004	Arteries expressing iNOS generated NO and relaxed when challenged with L-arginine (30 microM), an effect that was reduced by treatment with dexamethasone (coincubated with LPS) and prevented by the iNOS inhibitor 1400 W (administered 10 min prior to precontraction).	Arginine	71-81	nitric oxide synthase 2	Sus scrofa	20-24
15604045-3	2004	Arteries expressing iNOS generated NO and relaxed when challenged with L-arginine (30 microM), an effect that was reduced by treatment with dexamethasone (coincubated with LPS) and prevented by the iNOS inhibitor 1400 W (administered 10 min prior to precontraction).	Arginine	71-81	nitric oxide synthase 2	Sus scrofa	198-202
15801573-1	2004	Exogenous treatment with L-arginine has been shown to restore impaired nitric oxide synthase (NOS)-dependent dilatation of peripheral blood vessels during disease states.	Arginine	25-35	nitric oxide synthase 2	Homo sapiens	71-92
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	116-119	Serpin 42Da	Drosophila melanogaster	69-74
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	120-123	Serpin 42Da	Drosophila melanogaster	69-74
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	120-123	Serpin 42Da	Drosophila melanogaster	69-74
15198931-9	2004	In contrast, preincubation with a V(1) receptor antagonist, [beta-Mercapto-beta,beta-cyclopentamethylenepropionyl(1),O-Me-Tyr(2),Arg(8)]-vasopressin, prior to dDAVP treatment resulted in a greater increase of the uPA concentration in the medium than with the dDAVP treatment alone.	Arginine	129-132	plasminogen activator, urokinase	Homo sapiens	213-216
15531309-6	2004	Genetic analysis identified a G-->A substitution at nucleotide position 1334 in exon 14 of OPA1 causing an arginine-to-histidine change (R445H) in all affected members of the family.	Arginine	107-115	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	91-95
15565374-5	2004	Insulin responses were evaluated in vivo using the mixed meal tolerance test (2 g/kg oral glucose) and in the isolated perfused pancreata from the same animals by stimulation with glucose, glucagon-like peptide-1 or arginine.	Arginine	216-224	insulin	Homo sapiens	0-7
15533911-1	2004	A polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline.	Arginine	96-104	tumor protein p53	Homo sapiens	57-60
15550149-4	2004	DNA sequencing disclosed a heterozygous G--&gt;A substitution at nucleotide 893, that converts an arginine residue (CGA) to glutamine (CAA), the mutation being designated R298Q.	Arginine	98-106	chromogranin A	Homo sapiens	116-119
15565374-8	2004	Total in vitro insulin secretion was increased per unit of beta cell mass in nicotinamide + streptozotocin pancreata compared to controls (83.7+/-45.9 vs 34.6+/-14.4 nmol/mg beta cells, p&lt;0.05) with responses to glucose and glucagon-like peptide-1 showing a partial compensation for reduced beta cell mass, whereas no compensation was seen in response to arginine.	Arginine	358-366	insulin	Homo sapiens	15-22
15240561-6	2004	Sia removal or mutation of a CD22 arginine residue required for Sia recognition did not affect these associations even in human:mouse heterologous systems, indicating that they are primarily determined by evolutionarily conserved protein-protein interactions.	Arginine	34-42	CD22 molecule	Homo sapiens	29-33
15304551-10	2004	Both desArg(10)-kallidin and ACE inhibitors enhance arginine uptake and release NO independent of [Ca(2+)](i) elevation.	Arginine	52-60	angiotensin I converting enzyme	Homo sapiens	29-32
15364898-7	2004	However, in the presence of Arg allele of Arg16Gly and Gln allele of Gln27Glu, homozygosity for Leu variant of the Leu7Pro polymorphism was associated with 2.1-increased odds ratio (confidence interval, 1.10 to 3.81; P=0.024) of elevated LDL in hypertensive subjects, independent of age, gender, body mass index, adjusted blood pressures, antihypertensive therapy, and use of nonselective beta-blockers and diuretics.	Arginine	28-31	beta-1,3-glucuronyltransferase 1	Homo sapiens	115-119
15485929-0	2004	Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.	Arginine	53-61	protein arginine methyltransferase 5	Homo sapiens	25-30
15485929-0	2004	Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.	Arginine	53-61	suppression of tumorigenicity 7	Homo sapiens	103-106
15485929-3	2004	Here we report that PRMT5 can be found in association with endogenous hSWI/SNF complexes, which can methylate H3 and H4 N-terminal tails, and show that H3 arginine 8 and H4 arginine 3 are preferred sites of methylation by recombinant and hSWI/SNF-associated PRMT5.	Arginine	155-163	protein arginine methyltransferase 5	Homo sapiens	20-25
15485929-3	2004	Here we report that PRMT5 can be found in association with endogenous hSWI/SNF complexes, which can methylate H3 and H4 N-terminal tails, and show that H3 arginine 8 and H4 arginine 3 are preferred sites of methylation by recombinant and hSWI/SNF-associated PRMT5.	Arginine	173-181	protein arginine methyltransferase 5	Homo sapiens	20-25
15501530-0	2004	Urotensin-II activates L-arginine/nitric oxide pathway in isolated rat aortic adventitia.	Arginine	23-33	urotensin 2	Rattus norvegicus	0-12
15501530-3	2004	The present study aimed to elucidate the activation of U-II on L-arginine/NO pathway in isolated rat aortic adventitia.	Arginine	63-73	urotensin 2	Rattus norvegicus	55-59
15501530-9	2004	In conclusion, the results showed that rat U-II activated L-arginine/NOS/NO pathway in rat aortic adventitia, suggesting a potential contributive role of adventitia-derived NO in the vasodilator response of U-II.	Arginine	58-68	urotensin 2	Rattus norvegicus	43-47
15501530-9	2004	In conclusion, the results showed that rat U-II activated L-arginine/NOS/NO pathway in rat aortic adventitia, suggesting a potential contributive role of adventitia-derived NO in the vasodilator response of U-II.	Arginine	58-68	urotensin 2	Rattus norvegicus	207-211
15531073-2	2004	Trans-membrane l-arginine transportation mediated by the isozymes of cationic amino acid transporters (e.g. CAT-1, CAT-2, CAT-2A, and CAT-2B) is one crucial regulatory mechanism that regulates iNOS activity.	Arginine	15-25	nitric oxide synthase 2	Rattus norvegicus	193-197
15519228-4	2004	It was found that L-Arg and L-Glu could bind with cytochrome c to form noncovalent complexes.	Arginine	18-23	cytochrome c, somatic	Homo sapiens	50-62
15519228-5	2004	At low pH solution, complexes between the cytochrome c molecule with several L-Arg molecules (multiple L-Arg adducts) were formed, and the number of binding ligands depended on the charge state of cytochrome c.	Arginine	77-82	cytochrome c, somatic	Homo sapiens	42-54
15519228-5	2004	At low pH solution, complexes between the cytochrome c molecule with several L-Arg molecules (multiple L-Arg adducts) were formed, and the number of binding ligands depended on the charge state of cytochrome c.	Arginine	77-82	cytochrome c, somatic	Homo sapiens	197-209
15519228-5	2004	At low pH solution, complexes between the cytochrome c molecule with several L-Arg molecules (multiple L-Arg adducts) were formed, and the number of binding ligands depended on the charge state of cytochrome c.	Arginine	103-108	cytochrome c, somatic	Homo sapiens	42-54
15519228-5	2004	At low pH solution, complexes between the cytochrome c molecule with several L-Arg molecules (multiple L-Arg adducts) were formed, and the number of binding ligands depended on the charge state of cytochrome c.	Arginine	103-108	cytochrome c, somatic	Homo sapiens	197-209
15519228-6	2004	While in neutral solution, the cytochrome c molecule complexed with only one L-Arg molecule (single L-Arg adducts).	Arginine	77-82	cytochrome c, somatic	Homo sapiens	31-43
15519228-6	2004	While in neutral solution, the cytochrome c molecule complexed with only one L-Arg molecule (single L-Arg adducts).	Arginine	100-105	cytochrome c, somatic	Homo sapiens	31-43
15880928-4	2004	The circular dichroism spectra indicated that the incorporation of arginine significantly altered the conformation of thrombin; while no obvious variation in the conformation of thrombin was observed with the addition of CS.	Arginine	67-75	coagulation factor II, thrombin	Homo sapiens	118-126
15476400-0	2004	Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1.	Arginine	19-27	seed linoleate 13S-lipoxygenase-1	Glycine max	92-106
15326173-0	2004	Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine.	Arginine	85-93	metacaspase 9	Arabidopsis thaliana	31-36
15304513-4	2004	Here we tested whether mice containing the His to Arg point mutation in the alpha1, alpha2, or alpha3 subunit at positions 101, 101, and 126, respectively, which render the respective subunits insensitive to diazepam, would be suitable to analyze this issue.	Arginine	50-53	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	84-101
15369763-10	2004	These results suggest that the activity responsible for the formation of asymmetric dimethylated arginine residues in Sm proteins is either PRMT5 or a protein associated with it in the immunoprecipitated complex.	Arginine	97-105	protein arginine methyltransferase 5	Homo sapiens	140-145
15471567-0	2004	Different functional roles of arginine residues 39 and 61 and tyrosine residue 98 in transport and channel mode of the glutamate transporter EAAC1.	Arginine	30-38	solute carrier family 1 member 1	Homo sapiens	141-146
15334060-4	2004	PRMT3 catalyses the post-translational transfer of methyl groups from S-adenosyl-L-methionine to arginine residues of proteins.	Arginine	97-105	protein arginine methyltransferase 3	Homo sapiens	0-5
15383329-3	2004	Human FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain.	Arginine	108-116	WAPL cohesin release factor	Homo sapiens	6-9
15385959-5	2004	Our experiments successfully uncouple the Tat transport and cofactor-insertion activities of the TorA-specific chaperone TorD and demonstrate unequivocally that TorD recognises the TorA twin-arginine signal peptide.	Arginine	191-199	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	42-45
15272024-6	2004	Lack of detection of C-terminal fragments, with the exception of 26-32, 28-32, and 29-32 fragments, suggested that arginine 25 should be the first cleavage site, generating histatin 6 and 26-32 fragments.	Arginine	115-123	histatin 3	Homo sapiens	173-183
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Arginine	57-65	one cut homeobox 1	Homo sapiens	16-20
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Arginine	57-65	CREB binding protein	Homo sapiens	84-87
15304484-6	2004	Mutation of the HNF6 Cut domain lysine 339 residue to an arginine residue abrogated CBP acetylation, which is required for HNF6 protein stability.	Arginine	57-65	one cut homeobox 1	Homo sapiens	123-127
15473884-13	2004	Arginine increased (P &lt; 0.01) GH, insulin, glucagon and glucose (P &lt; 0.05) but did not affect ghrelin secretion.	Arginine	0-8	insulin	Homo sapiens	37-44
15483745-1	2004	Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene.	Arginine	33-43	nitric oxide synthase 3	Homo sapiens	47-80
15483745-1	2004	Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene.	Arginine	33-43	nitric oxide synthase 3	Homo sapiens	92-96
15554917-3	2004	The l-arginine analogues asymmetric dimethylarginine (ADMA) and N(G)-monomethyl-l-arginine (l-NMMA) are endogenous inhibitors of nitric oxide synthase (NOS), involved in the physiopathology of arterial hypertension.	Arginine	4-14	nitric oxide synthase 2	Homo sapiens	129-150
15331780-5	2004	In contrast to the adjacent conserved kallikrein-like genes, the CD33rSiglec genes showed extensive species differences, including expansions of gene subsets; gene deletions, including one human-specific loss of a novel functional primate Siglec (Siglec-13); exon shuffling, generating hybrid genes; accelerated accumulation of nonsynonymous substitutions in the Sia-recognition domain; and multiple instances of mutations of an arginine residue essential for Sia recognition in otherwise intact Siglecs.	Arginine	429-437	CD33 molecule	Homo sapiens	65-69
15465788-1	2004	L-arginine, the principal substrate for endothelial nitric oxide synthase, is oxidized to L-citrulline and nitric oxide.	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	40-73
15465789-4	2004	L-arginine supplementation in animal models of glomerulonephritis has been shown to be detrimental, probably by increasing the production of NO from increased local expression of inducible NO synthase (iNOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	179-200
15465789-4	2004	L-arginine supplementation in animal models of glomerulonephritis has been shown to be detrimental, probably by increasing the production of NO from increased local expression of inducible NO synthase (iNOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	202-206
15465794-7	2004	In vascular endothelium, endotoxin stimulates arginine uptake, an effect that is mediated by the cytokine tumor necrosis factor-alpha (TNF-alpha) and by the cyclo-oxygenase pathway.	Arginine	46-54	tumor necrosis factor	Homo sapiens	106-133
15465794-7	2004	In vascular endothelium, endotoxin stimulates arginine uptake, an effect that is mediated by the cytokine tumor necrosis factor-alpha (TNF-alpha) and by the cyclo-oxygenase pathway.	Arginine	46-54	tumor necrosis factor	Homo sapiens	135-144
15465794-12	2004	PKC and mitogen-activated protein kinases are involved in mediating the sepsis/acidosis stimulation of arginine transport.	Arginine	103-111	proline rich transmembrane protein 2	Homo sapiens	0-3
15465796-4	2004	Arginine also promotes wound healing and functions as a secretagogue stimulating the release of growth hormone, insulin-like growth factor 1, insulin, and prolactin.	Arginine	0-8	insulin	Homo sapiens	112-119
15465796-4	2004	Arginine also promotes wound healing and functions as a secretagogue stimulating the release of growth hormone, insulin-like growth factor 1, insulin, and prolactin.	Arginine	0-8	insulin	Homo sapiens	142-149
15465801-6	2004	Recent studies using chemical inhibitors of nitric oxide synthase (NOS) suggest that nitric oxide derived from Arg could be partly involved in OKG activity.	Arginine	111-114	nitric oxide synthase 2	Homo sapiens	44-65
15465804-2	2004	Nitric oxide synthase (NOS) utilizes L-arginine and oxygen as substrates to produce nitric oxide (NO) and citrulline.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	0-21
15465806-3	2004	L-arginine is a conditionally essential amino acid that has received considerable attention due to potential effects on growth hormone secretion and nitric oxide production.	Arginine	0-10	growth hormone 1	Homo sapiens	120-134
15544543-5	2004	Arginine has many effects in the body that include modulation of immune function, wound healing, hormone secretion, vascular tone, insulin sensitivity, and endothelial function.	Arginine	0-8	insulin	Homo sapiens	131-138
15234970-7	2004	At a Ca(2+)(o) of 1.1 mm and an amino acid concentration of 1 mm, CaR-active amino acids (l-Phe = l-Trp &gt; l-His = l-Ala), but not CaR-inactive amino acids (l-Leu and l-Arg), stereoselectively suppressed PTH secretion by up to 40%, similar to the effect of raising Ca(2+)(o) to 1.2 mm.	Arginine	169-174	calcium sensing receptor	Homo sapiens	66-69
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Arginine	152-160	hemolytic complement	Mus musculus	227-230
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	angiotensinogen	Homo sapiens	63-77
15245332-2	2004	In the present paper, we have characterized maize (Zea mays L.) photosynthetic NADP(+)-ME mutants in which conserved basic residues (lysine and arginine) were changed by site-directed mutagenesis.	Arginine	144-152	NADP-dependent malic enzyme	Zea mays	79-89
15245332-5	2004	At the same time, further characterization of the NADP(+)-ME R237L mutant indicates that Arg-237 is also a candidate for such role.	Arginine	89-92	NADP-dependent malic enzyme	Zea mays	50-60
15356163-1	2004	The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin.	Arginine	44-47	complement C5a receptor 1	Homo sapiens	36-39
15356163-1	2004	The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin.	Arginine	44-47	D-box binding PAR bZIP transcription factor	Homo sapiens	112-115
15315617-2	2004	Cellular uptake of L-arginine, the sole substrate for iNOS, is an important mechanism regulating NO biosynthesis by iNOS.	Arginine	19-29	nitric oxide synthase 2	Rattus norvegicus	54-58
15315617-2	2004	Cellular uptake of L-arginine, the sole substrate for iNOS, is an important mechanism regulating NO biosynthesis by iNOS.	Arginine	19-29	nitric oxide synthase 2	Rattus norvegicus	116-120
15289285-8	2004	Additionally, endothelial NO synthase (eNOS) activity was measured in EA.hy 926 cell homogenates by an l-[(3)H]citrulline/l-[(3)H]arginine conversion assay.	Arginine	130-138	nitric oxide synthase 3	Homo sapiens	39-43
15379714-4	2004	Synthetic thrombin inhibitors have a long history; initial compounds were derived from electrophilic ketone- and aldehyde-analogs of arginine.	Arginine	133-141	coagulation factor II, thrombin	Homo sapiens	10-18
15131588-1	2004	A common arginine to proline polymorphism is harboured at codon 72 of the human p53 gene.	Arginine	9-17	tumor protein p53	Homo sapiens	80-83
15355447-5	2004	All patients underwent wide basal hormonal evaluation; the GH/IGF-I axis was evaluated by GHRH + arginine test and IGF-I measurement.	Arginine	97-105	insulin like growth factor 1	Homo sapiens	62-67
15350190-11	2004	L-Arginine to L-citrulline conversion assays showed that ATP, EGF and VEGF induced a significant rise in eNOS activity, and this correlates with an ability to induce Ca2+ mobilization and ERK 2 activation.	Arginine	0-10	vascular endothelial growth factor A	Homo sapiens	70-74
15324932-0	2004	Influence of arginine deimination on antigenicity of fibrinogen.	Arginine	13-21	fibrinogen beta chain	Homo sapiens	53-63
15342575-7	2004	A123, equivalent to the conserved residue A124 in E. coli ArgR involved in arginine binding, was different in the wild-type ArgR2.	Arginine	75-83	arginine repressor	Escherichia coli	58-62
15350190-11	2004	L-Arginine to L-citrulline conversion assays showed that ATP, EGF and VEGF induced a significant rise in eNOS activity, and this correlates with an ability to induce Ca2+ mobilization and ERK 2 activation.	Arginine	0-10	mitogen-activated protein kinase 1	Homo sapiens	188-193
15453585-6	2004	However, the peptide Tyr-Ala-Glu-Glu-Arg-Tyr-Pro-Ile-Leu, which was a strong ACE inhibitor (50% inhibitory concentration, 4.7 microM) also exhibited a high radical scavenging activity (oxygen radical absorbance capacity-fluorescein value, 3.8 micromol of Trolox equivalent per micromol of peptide) and delayed the low-density lipoprotein lipid oxidation induced by Cu2+ at a concentration of approximately 0.16 mg/mg of low-density lipoprotein.	Arginine	37-40	angiotensin I converting enzyme	Homo sapiens	77-80
15548361-1	2004	According to recent reports, some cancer types exhibit nonrandom allele loss at codon 72 in exon 4 of the p53 gene [coding for proline (72Pro) or arginine (72Arg)].	Arginine	146-154	tumor protein p53	Homo sapiens	106-109
15322246-2	2004	In this work, we focus on the sulfated tyrosyl residue in position 27 of cholecystokinin (CCK) and its spatial approximation with the type A CCK receptor residue Arg(197) that has been predicted from mutagenesis experiments.	Arginine	162-165	cholecystokinin	Homo sapiens	73-88
15322246-2	2004	In this work, we focus on the sulfated tyrosyl residue in position 27 of cholecystokinin (CCK) and its spatial approximation with the type A CCK receptor residue Arg(197) that has been predicted from mutagenesis experiments.	Arginine	162-165	cholecystokinin	Homo sapiens	90-93
15322246-2	2004	In this work, we focus on the sulfated tyrosyl residue in position 27 of cholecystokinin (CCK) and its spatial approximation with the type A CCK receptor residue Arg(197) that has been predicted from mutagenesis experiments.	Arginine	162-165	cholecystokinin	Homo sapiens	141-144
15327764-1	2004	The recent identification of the NFAT-interacting protein NIP45 as a methylated protein by marks a new role for protein arginine methylation in lymphocyte signaling and cytokine gene activation.	Arginine	120-128	nuclear factor of activated T cells 2 interacting protein	Homo sapiens	58-63
15569536-11	2004	An A5521G mutation (GAG--&gt;AAG) in the exon 38 was found in the proband and her diseased father, resulting in a characteristic change of NMMHC-A1841 (Glutamic acid--&gt;Arginine), which was not found in other members of the family and in normal controls.	Arginine	171-179	myosin heavy chain 9	Homo sapiens	139-146
15742977-4	2004	A CYP1A2 1117 C&gt;T single nucleotide polymorphism was found, which resulted in an amino acid change from an Arg codon to a stop codon at position 373.	Arginine	110-113	cytochrome P450 family 1 subfamily A member 2	Canis lupus familiaris	2-8
15208323-9	2004	Therefore, despite having previously identified Arg-4, Pro-5, Leu-8, and Leu-10 in TI-JIP as independently critical for mediating JNK inhibition, we find their presence in other 11-mer peptides is not sufficient for JNK inhibition.	Arginine	48-51	mitogen-activated protein kinase 8	Homo sapiens	130-133
15327772-3	2004	Inhibition of arginine methylation impaired the expression of several cytokine genes, including the signature type 1 and type 2 helper cytokines, interferon gamma, and interleukin-4.	Arginine	14-22	interferon gamma	Mus musculus	146-162
15210694-3	2004	Here we show that substitutions of Arg-462 and Cys-463 residues, which are in proximity of the C-terminal serine residues, inhibited TGFbeta type I receptor-dependent phosphorylation of the C-terminal Smad2 peptides and full-length GST-Smad2 proteins in vitro.	Arginine	35-38	transforming growth factor beta 1	Homo sapiens	133-140
15159396-2	2004	Although both enzymes prefer Arg at P(1) and basic residues at P(2), the two differ in recognition of P(4) and P(6) residues.	Arginine	29-32	exosome component 10	Homo sapiens	102-106
15159396-2	2004	Although both enzymes prefer Arg at P(1) and basic residues at P(2), the two differ in recognition of P(4) and P(6) residues.	Arginine	29-32	S100 calcium binding protein A12	Homo sapiens	111-115
15159396-4	2004	T252D and Q283E mutations were introduced to increase the preference for Arg at P(4) and P(6), respectively.	Arginine	73-76	exosome component 10	Homo sapiens	80-84
15159396-4	2004	T252D and Q283E mutations were introduced to increase the preference for Arg at P(4) and P(6), respectively.	Arginine	73-76	S100 calcium binding protein A12	Homo sapiens	89-93
15159396-5	2004	Glu(255) was replaced with Ile to limit recognition of P(4) Arg.	Arginine	60-63	exosome component 10	Homo sapiens	55-59
15159396-7	2004	Whereas wild Kex2 exhibited little preference type for Arg at P(6), the T252D mutant and T252D/Q283E double mutant exhibited clear interactions with P(6) Arg.	Arginine	154-157	S100 calcium binding protein A12	Homo sapiens	149-153
15159396-11	2004	E255I-Kex2 exhibited significantly decreased recognition of P(4) Arg in a tetrapeptide substrate with Lys at P(1), although the general pattern of selectivity for aliphatic residues at P(4) remained unchanged.	Arginine	65-68	exosome component 10	Homo sapiens	60-64
15210694-4	2004	In vivo, mutation of Arg-462 and Cys-463 inhibited TGFbeta1-stimulated phosphorylation of the C-terminal serine residues in Smad2.	Arginine	21-24	transforming growth factor beta 1	Homo sapiens	51-59
15210694-6	2004	Thus, Arg-462 and Cys-463, which are in proximity of the C-terminal serine residues, contribute to recognition and phosphorylation of the C terminus of Smad2 by type I TGFbeta receptor.	Arginine	6-9	transforming growth factor beta 1	Homo sapiens	168-175
15302922-6	2004	Multiple p53 sequence alignments with 41 additional species confirmed that Arg-174 is highly conserved.	Arginine	75-78	tumor protein p53	Homo sapiens	9-12
15302922-10	2004	A DNA-free p53 structure model predicts that Arg-174 is important for dimerization, whereas Spalax Lys-174 prevents such interactions.	Arginine	45-48	tumor protein p53	Homo sapiens	11-14
15298966-0	2004	The CYP19 gene codon 39 Trp/Arg polymorphism increases breast cancer risk in subsets of premenopausal Japanese.	Arginine	28-31	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	4-9
15246005-3	2004	Specifically, in this study, CN-based methodology was used to trap a 1-disulfide bond and a 2-disulfide intermediate of long Arg(3) insulin-like growth factor-I (LR(3)IGF-I), which was then exposed to HDX using D(2)O at pD 6.8 and subsequently digested with pepsin before analysis by matrix-assisted laser desorption/ionization mass spectrometry.	Arginine	125-128	insulin like growth factor 1	Homo sapiens	167-172
15334469-8	2004	Enzymatic cleavage of aggrecan at the TEGE(373-374)ARGS site was clearly evident after exposure of articular cartilage from ADAMTS-4-KO mice to inflammatory cytokines.	Arginine	51-55	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	124-132
15270786-0	2004	Paraoxonase 1 Gln/Arg polymorphism is associated with the risk of microangiopathy in Type 2 diabetes mellitus.	Arginine	18-21	paraoxonase 1	Homo sapiens	0-13
15554459-12	2004	L-Arg administration caused an important decrease in cardiac ACE activity (2K1C-L-Arg: 118 +/- 15; 2K1C: 266 +/- 34 micromol/min/mg; P &lt; 0.01).	Arginine	0-5	angiotensin I converting enzyme	Rattus norvegicus	61-64
15554459-12	2004	L-Arg administration caused an important decrease in cardiac ACE activity (2K1C-L-Arg: 118 +/- 15; 2K1C: 266 +/- 34 micromol/min/mg; P &lt; 0.01).	Arginine	2-5	angiotensin I converting enzyme	Rattus norvegicus	61-64
15554459-13	2004	L-Arg also decreased the ACE activity in the clipped kidney by 47% (P &lt; 0.01), but not in the nonclipped kidney.	Arginine	0-5	angiotensin I converting enzyme	Rattus norvegicus	25-28
15554459-14	2004	These data suggest that increased NO formation and reduced angiotensin II formation are involved in the anthihypertensive effect of orally administered L-arginine.	Arginine	152-162	angiotensinogen	Rattus norvegicus	59-73
15270786-4	2004	Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gln/Gln vs. Gln/Arg and Arg/Arg].	Arginine	48-51	paraoxonase 1	Homo sapiens	68-72
15270786-4	2004	Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gln/Gln vs. Gln/Arg and Arg/Arg].	Arginine	218-221	paraoxonase 1	Homo sapiens	68-72
15270786-4	2004	Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gln/Gln vs. Gln/Arg and Arg/Arg].	Arginine	218-221	paraoxonase 1	Homo sapiens	68-72
15270786-4	2004	Among the gene polymorphisms tested, the 192Gln/Arg polymorphism of PON1 was associated with the prevalence of retinopathy [odds ratio (OR) = 3.13, 95% confidence interval (CI) = 1.42-6.89, P = 0.0046, Gln/Gln vs. Gln/Arg and Arg/Arg].	Arginine	218-221	paraoxonase 1	Homo sapiens	68-72
15208269-6	2004	Consistent with this finding, HNPs bound to and promoted the binding of fibronectin to alpha5beta1 integrin in arginine-glycine-aspartic acid (RGD)-independent manner.	Arginine	111-119	fibronectin 1	Homo sapiens	72-83
15554555-8	2004	Our results suggest that homozygous arginine at codon 72 of p53 may represent a risk factor for developing ovarian malignancies and may affect the differentiation of endometrial cancer.	Arginine	36-44	tumor protein p53	Homo sapiens	60-63
15271890-3	2004	Analysis by polyacrylamide gel electrophoresis and Western immunoblotting showed that preparations of Arg- and Lys-gingipains of P. gingivalis cleave transferrin (iron-free and iron-saturated forms) into fragments of various sizes.	Arginine	102-105	transferrin	Homo sapiens	150-161
15447819-10	2004	CONCLUSION: L-arginine supplementation could be beneficial to the angiogenesis in the burn wound of the rats with diabetes, as well as to wound healing by increasing the synthesis and the release of VEGF, NO and TGF-beta1 from burn wound and by decreasing the glucose content in the cutaneous tissue of diabetic rats.	Arginine	12-22	transforming growth factor, beta 1	Rattus norvegicus	212-221
15265947-1	2004	Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use the same substrate, l-arginine (Arg).	Arginine	115-125	nitric oxide synthase 2, inducible	Mus musculus	40-61
15265947-1	2004	Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use the same substrate, l-arginine (Arg).	Arginine	115-125	nitric oxide synthase 2, inducible	Mus musculus	63-67
15265947-1	2004	Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use the same substrate, l-arginine (Arg).	Arginine	0-3	nitric oxide synthase 2, inducible	Mus musculus	40-61
15265947-1	2004	Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use the same substrate, l-arginine (Arg).	Arginine	0-3	nitric oxide synthase 2, inducible	Mus musculus	63-67
15265947-5	2004	l-Arg supplementation of wild-type mice or iNOS deletion significantly improved colitis, and l-Arg treatment of iNOS(-/-) mice led to an additive improvement.	Arginine	93-98	nitric oxide synthase 2, inducible	Mus musculus	112-116
15265947-6	2004	There was a significant induction of IFN-gamma, IL-1, and TNF-alpha mRNA expression in colitis tissues that was markedly attenuated with l-Arg treatment or iNOS deletion.	Arginine	137-142	interferon gamma	Mus musculus	37-46
15265947-6	2004	There was a significant induction of IFN-gamma, IL-1, and TNF-alpha mRNA expression in colitis tissues that was markedly attenuated with l-Arg treatment or iNOS deletion.	Arginine	137-142	tumor necrosis factor	Mus musculus	58-67
15118070-0	2004	An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypes.	Arginine	45-53	androgen receptor	Homo sapiens	65-82
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Arginine	207-210	MTOR associated protein, LST8 homolog	Homo sapiens	166-170
15262267-3	2004	Of 35 amino acids quantified, we found significant dysregulation in SSADH(-/-) mice for 11 (GABA, glutamate, glutamine, alanine, aspartate, serine, taurine, cystathionine, methionine, homocarnosine, and arginine) as compared to age-matched littermates both before, and following, the period of generalized convulsive seizures and status epilepticus.	Arginine	203-211	aldhehyde dehydrogenase family 5, subfamily A1	Mus musculus	68-73
15123679-9	2004	These data identify a third loss-of-function polymorphism affecting the human P2X(7) receptor, and since the affected Arg(307) is homologous to those amino acids essential for ATP binding to P2X(1) and P2X(2), it is likely that this polymorphism abolishes the binding of ATP to the extracellular domain of P2X(7).	Arginine	118-121	purinergic receptor P2X 7	Homo sapiens	78-93
15159392-7	2004	Solution studies using ETF and MCAD with mutations at the protein-protein interface support this dynamic model and indicate ionic interactions between MCAD Glu(212) and ETF Arg alpha(249) are likely to transiently stabilize productive conformations of the FAD domain leading to enhanced electron transfer rates between both partners.	Arginine	173-176	acyl-CoA dehydrogenase medium chain	Homo sapiens	31-35
15159392-7	2004	Solution studies using ETF and MCAD with mutations at the protein-protein interface support this dynamic model and indicate ionic interactions between MCAD Glu(212) and ETF Arg alpha(249) are likely to transiently stabilize productive conformations of the FAD domain leading to enhanced electron transfer rates between both partners.	Arginine	173-176	acyl-CoA dehydrogenase medium chain	Homo sapiens	151-155
15123679-9	2004	These data identify a third loss-of-function polymorphism affecting the human P2X(7) receptor, and since the affected Arg(307) is homologous to those amino acids essential for ATP binding to P2X(1) and P2X(2), it is likely that this polymorphism abolishes the binding of ATP to the extracellular domain of P2X(7).	Arginine	118-121	purinergic receptor P2X 7	Homo sapiens	78-84
15166218-0	2004	Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.	Arginine	121-131	nitric oxide synthase 3	Homo sapiens	50-83
15260484-4	2004	We have demonstrated that certain polar residues within a number of TM helices, including Arg(593) in TM11, are determinants of MRP1 substrate specificity or overall activity.	Arginine	90-93	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
15245898-7	2004	In this first approach, cathepsin L was used to cleave a linker sequence including a cathepsin L site: afrsaaq, thereby releasing the tri-peptide Arg-Gly-Asp (RGD) from the PNA anchor.	Arginine	146-149	cathepsin L	Homo sapiens	24-35
15245898-7	2004	In this first approach, cathepsin L was used to cleave a linker sequence including a cathepsin L site: afrsaaq, thereby releasing the tri-peptide Arg-Gly-Asp (RGD) from the PNA anchor.	Arginine	146-149	cathepsin L	Homo sapiens	85-96
15183530-1	2004	A common germline polymorphism of p53 gene produces an Arginine to Proline change at aminoacid position 72.	Arginine	55-63	tumor protein p53	Homo sapiens	34-37
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Gcn1p	Saccharomyces cerevisiae S288C	29-33
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Gcn1p	Saccharomyces cerevisiae S288C	74-78
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Gcn1p	Saccharomyces cerevisiae S288C	74-78
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Gcn1p	Saccharomyces cerevisiae S288C	74-78
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Gcn1p	Saccharomyces cerevisiae S288C	74-78
15247425-3	2004	Here we report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site, -Arg(P4)-Arg-Lys-Arg(P1) downsream-, in its reactive site loop (RSL).	Arginine	203-206	Serpin 42Da	Drosophila melanogaster	37-42
15247425-3	2004	Here we report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site, -Arg(P4)-Arg-Lys-Arg(P1) downsream-, in its reactive site loop (RSL).	Arginine	211-214	Serpin 42Da	Drosophila melanogaster	37-42
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	106-109	Serpin 42Da	Drosophila melanogaster	23-28
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	106-109	Serpin 42Da	Drosophila melanogaster	93-98
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Serpin 42Da	Drosophila melanogaster	23-28
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Serpin 42Da	Drosophila melanogaster	93-98
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Serpin 42Da	Drosophila melanogaster	23-28
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Serpin 42Da	Drosophila melanogaster	93-98
15183535-9	2004	Frequency of ER positive tumors was significantly (p &lt; 0.01) higher in breast cancer patients with p5372Pro/Pro genotype (82.8%) than those with p5372Arg/Arg genotype (54.5%).	Arginine	153-156	estrogen receptor 1	Homo sapiens	13-15
15183535-12	2004	The higher frequency of p53 somatic mutation in p5372Arg/Arg homozygotes than p5372Pro/Pro homozygotes is consistent with the thesis that the function of p5372Pro/Pro is impaired so that a further alteration of p53 gene is less required in p5372Pro/Pro homozygotes than p5372Arg/Arg homozygotes.	Arginine	53-56	tumor protein p53	Homo sapiens	24-27
15183535-12	2004	The higher frequency of p53 somatic mutation in p5372Arg/Arg homozygotes than p5372Pro/Pro homozygotes is consistent with the thesis that the function of p5372Pro/Pro is impaired so that a further alteration of p53 gene is less required in p5372Pro/Pro homozygotes than p5372Arg/Arg homozygotes.	Arginine	53-56	tumor protein p53	Homo sapiens	48-51
15183535-12	2004	The higher frequency of p53 somatic mutation in p5372Arg/Arg homozygotes than p5372Pro/Pro homozygotes is consistent with the thesis that the function of p5372Pro/Pro is impaired so that a further alteration of p53 gene is less required in p5372Pro/Pro homozygotes than p5372Arg/Arg homozygotes.	Arginine	57-60	tumor protein p53	Homo sapiens	24-27
15183535-12	2004	The higher frequency of p53 somatic mutation in p5372Arg/Arg homozygotes than p5372Pro/Pro homozygotes is consistent with the thesis that the function of p5372Pro/Pro is impaired so that a further alteration of p53 gene is less required in p5372Pro/Pro homozygotes than p5372Arg/Arg homozygotes.	Arginine	57-60	tumor protein p53	Homo sapiens	48-51
15238257-7	2004	These results indicate that in human endothelial cells the activation of NF-kappaB pathway mediates the TNFalpha effects on arginine transport.	Arginine	124-132	tumor necrosis factor	Homo sapiens	104-112
15290337-4	2004	The temporal switch of arginine as a substrate for the cytostatic iNOS/NO axis to the pro-growth arginase/ ornithine/polyamine and proline axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	23-31	nitric oxide synthase 2	Homo sapiens	66-70
14998786-7	2004	Similarly, in 2-DM subjects, spontaneous insulin oscillations were entrained by arginine; mean basal insulin period was 10.0 +/- 1.0 min and 14.5 +/- 1.8 min with arginine boluses (P &lt; 0.00001).	Arginine	80-88	insulin	Homo sapiens	41-48
14998786-7	2004	Similarly, in 2-DM subjects, spontaneous insulin oscillations were entrained by arginine; mean basal insulin period was 10.0 +/- 1.0 min and 14.5 +/- 1.8 min with arginine boluses (P &lt; 0.00001).	Arginine	163-171	insulin	Homo sapiens	41-48
14998786-10	2004	Thus arginine boluses entrain spontaneous high-frequency insulin oscillations in 2-DM subjects.	Arginine	5-13	insulin	Homo sapiens	57-64
15238257-0	2004	The stimulation of arginine transport by TNFalpha in human endothelial cells depends on NF-kappaB activation.	Arginine	19-27	tumor necrosis factor	Homo sapiens	41-49
15238257-1	2004	In human saphenous vein endothelial cells (HSVECs), tumor necrosis factor-alpha (TNFalpha) and bacterial lipopolysaccharide (LPS), but neither interferon gamma (IFNgamma) nor interleukin 1beta (IL-1beta), stimulate arginine transport.	Arginine	215-223	tumor necrosis factor	Homo sapiens	52-79
15230885-0	2004	Association of p53 arginine polymorphism with skin cancer.	Arginine	19-27	tumor protein p53	Homo sapiens	15-18
15223139-1	2004	Measurement of the temperature-dependence of thrombin-catalyzed cleavage of the Arg(155)-Ser(156) and Arg(284)-Thr(285) peptide bonds in prothrombin and prothrombin-derived substrates has yielded Arrhenius parameters that are far too large for classical mechanistic interpretation in terms of a simple hydrolytic reaction.	Arginine	80-83	coagulation factor II, thrombin	Homo sapiens	45-53
15223139-1	2004	Measurement of the temperature-dependence of thrombin-catalyzed cleavage of the Arg(155)-Ser(156) and Arg(284)-Thr(285) peptide bonds in prothrombin and prothrombin-derived substrates has yielded Arrhenius parameters that are far too large for classical mechanistic interpretation in terms of a simple hydrolytic reaction.	Arginine	102-105	coagulation factor II, thrombin	Homo sapiens	45-53
15257943-1	2004	A single nucleotide polymorphism at TP53 codon 72 means that two alleles exist: A1 (proline residue, Pro72) and A2 (arginine residue, Arg72).	Arginine	116-124	tumor protein p53	Homo sapiens	36-40
15308336-4	2004	The 51-amino-acid pre-pro-peptide contains the expected hydrophobic leader sequence and the dibasic Arg-Arg sequence preceding the NH2-terminal Ser of the mature 49-amino-acid Rana osteocalcin.	Arginine	100-103	bone gamma-carboxyglutamate protein	Rattus norvegicus	181-192
15308336-4	2004	The 51-amino-acid pre-pro-peptide contains the expected hydrophobic leader sequence and the dibasic Arg-Arg sequence preceding the NH2-terminal Ser of the mature 49-amino-acid Rana osteocalcin.	Arginine	104-107	bone gamma-carboxyglutamate protein	Rattus norvegicus	181-192
15310270-1	2004	Cysteine-arginine interchanges along the primary sequence of human plasma apolipoprotein E (apoE) play an important role in determining its biological functions due to a high mutation frequency of cytosine in CGX triplet that codes 33 of 34 apolipoprotein arginine residues.	Arginine	9-17	apolipoprotein E	Homo sapiens	74-90
15310270-1	2004	Cysteine-arginine interchanges along the primary sequence of human plasma apolipoprotein E (apoE) play an important role in determining its biological functions due to a high mutation frequency of cytosine in CGX triplet that codes 33 of 34 apolipoprotein arginine residues.	Arginine	9-17	apolipoprotein E	Homo sapiens	92-96
15310270-1	2004	Cysteine-arginine interchanges along the primary sequence of human plasma apolipoprotein E (apoE) play an important role in determining its biological functions due to a high mutation frequency of cytosine in CGX triplet that codes 33 of 34 apolipoprotein arginine residues.	Arginine	256-264	apolipoprotein E	Homo sapiens	74-90
15310270-1	2004	Cysteine-arginine interchanges along the primary sequence of human plasma apolipoprotein E (apoE) play an important role in determining its biological functions due to a high mutation frequency of cytosine in CGX triplet that codes 33 of 34 apolipoprotein arginine residues.	Arginine	256-264	apolipoprotein E	Homo sapiens	92-96
15044363-5	2004	In contrast, galanin KO mice had a reduced insulin response to glucose, both in vivo (P &lt; 0.001) and in isolated islets (P &lt; 0.001), and to arginine, both in vivo (P = 0.012) and in vitro (P = 0.018).	Arginine	146-154	galanin and GMAP prepropeptide	Mus musculus	13-20
15230885-1	2004	BACKGROUND: The presence of arginine at codon 72 in p53 protein is proposed to be a genetic risk factor in human papillomavirus (HPV)-related carcinogenesis.	Arginine	28-36	tumor protein p53	Homo sapiens	52-55
15230885-4	2004	RESULTS: All EV patients with the malignant form of EV were homozygous for arginine (Arg/Arg) at codon 72 of the p53 gene, in contrast to none with the benign form (P &lt; 0.0001).	Arginine	75-83	tumor protein p53	Homo sapiens	113-116
15230885-4	2004	RESULTS: All EV patients with the malignant form of EV were homozygous for arginine (Arg/Arg) at codon 72 of the p53 gene, in contrast to none with the benign form (P &lt; 0.0001).	Arginine	85-88	tumor protein p53	Homo sapiens	113-116
15230885-4	2004	RESULTS: All EV patients with the malignant form of EV were homozygous for arginine (Arg/Arg) at codon 72 of the p53 gene, in contrast to none with the benign form (P &lt; 0.0001).	Arginine	89-92	tumor protein p53	Homo sapiens	113-116
15230885-5	2004	CONCLUSIONS: p53 arginine polymorphism is likely to be associated with the development of skin malignancies in EV patients from Brazil.	Arginine	17-25	tumor protein p53	Homo sapiens	13-16
15240621-3	2004	The peak GH response evoked by combined arginine (0.5 g/kg infused iv over 30 min) and GHRH (1 microg/kg iv bolus) was measured in 59 healthy male subjects with BMIs ranging from normal to obese.	Arginine	40-48	growth hormone 1	Homo sapiens	9-11
15542451-10	2004	It shares the arginine residue with rat CNTF which prevents binding to IL-6Ralpha.	Arginine	14-22	ciliary neurotrophic factor	Rattus norvegicus	40-44
15542451-10	2004	It shares the arginine residue with rat CNTF which prevents binding to IL-6Ralpha.	Arginine	14-22	interleukin 6 receptor	Rattus norvegicus	71-81
15291403-23	2004	3: In the ARG group, ROI production with PMA and CD11b expression at 4 hours were higher than those at 2 hours, whereas there were no significant changes in the control mice.	Arginine	10-13	integrin alpha M	Mus musculus	49-54
15004000-7	2004	treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions.	Arginine	52-55	fibronectin 1	Homo sapiens	27-38
15004000-7	2004	treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions.	Arginine	52-55	fibronectin 1	Homo sapiens	114-125
15240653-3	2004	Recently, we found that human endothelial cells obtained from carriers of the Arg(972) IRS-1 polymorphism exhibited reduced eNOS expression in response to chronic exposure to insulin.	Arginine	78-81	nitric oxide synthase 3	Homo sapiens	124-128
15240653-3	2004	Recently, we found that human endothelial cells obtained from carriers of the Arg(972) IRS-1 polymorphism exhibited reduced eNOS expression in response to chronic exposure to insulin.	Arginine	78-81	insulin	Homo sapiens	175-182
15225135-8	2004	The islets generated within 3-4 weeks exhibited a mixed population of large- and small-sized islets with clear cut dichotomy in the pattern of their insulin secretion in response to L-arginine and glucose.	Arginine	182-192	insulin	Homo sapiens	149-156
15064952-1	2004	Insulin induces vasodilatation in human subjects and increases L-arginine transport and NO synthesis in human umbilical vein endothelial cells (HUVEC).	Arginine	63-73	insulin	Homo sapiens	0-7
15265272-2	2004	NO is synthesized by converting L-arginine to L-citrulline by enzymes called NO synthase (NOS).	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	77-88
15208638-4	2004	Inhibition of Met4 ubiquitination by mutating lysine to arginine at this position constitutively activates, but does not stabilize, Met4.	Arginine	56-64	Met4p	Saccharomyces cerevisiae S288C	14-18
15161993-7	2004	When L-Arg was added to the reaction medium, as a NO donor, the chemiluminescence of fMLP increased by up to 67% and that of PMA by up to 132%, but was once again significantly reduced by 5 and 10 microg/ml of Met I.	Arginine	5-10	formyl peptide receptor 1	Homo sapiens	85-89
15064952-3	2004	L-arginine transport and eNOS activity were determined in HUVEC exposed to insulin.	Arginine	0-10	insulin	Homo sapiens	75-82
15064952-6	2004	Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B and eNOS expression and activity.	Arginine	18-28	insulin	Homo sapiens	0-7
15064952-8	2004	Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression, via mechanisms involving membrane hyperpolarization, mitogen-activated protein kinases p42 and p44, phosphatidylinositol 3-kinase, NO and protein kinase C. We have characterized a cell signalling pathway by which hyperinsulinaemia could lead to vasodilatation in human subjects, and which could have implications in patients in whom plasma insulin levels are altered, such as in diabetes mellitus.	Arginine	36-46	insulin	Homo sapiens	0-7
15064952-8	2004	Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression, via mechanisms involving membrane hyperpolarization, mitogen-activated protein kinases p42 and p44, phosphatidylinositol 3-kinase, NO and protein kinase C. We have characterized a cell signalling pathway by which hyperinsulinaemia could lead to vasodilatation in human subjects, and which could have implications in patients in whom plasma insulin levels are altered, such as in diabetes mellitus.	Arginine	36-46	insulin	Homo sapiens	356-363
15078870-2	2004	In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center.	Arginine	52-55	leukotriene A4 hydrolase	Homo sapiens	34-50
15335153-11	2004	HPMC expressed eNOS (NOSIII) when grown in L-arginine-supplemented medium, shown by immunocytochemistry and by reverse transcriptase-polymer chain reaction.	Arginine	43-53	nitric oxide synthase 3	Homo sapiens	21-27
15242600-5	2004	The alpha helix in loop L3 of Cep-1 orients the side chains of two conserved arginines toward DNA; in human p53, both arginines are mutation hotspots, but only one contacts DNA.	Arginine	77-86	centriolin	Homo sapiens	30-35
15242600-5	2004	The alpha helix in loop L3 of Cep-1 orients the side chains of two conserved arginines toward DNA; in human p53, both arginines are mutation hotspots, but only one contacts DNA.	Arginine	118-127	centriolin	Homo sapiens	30-35
15242600-5	2004	The alpha helix in loop L3 of Cep-1 orients the side chains of two conserved arginines toward DNA; in human p53, both arginines are mutation hotspots, but only one contacts DNA.	Arginine	118-127	tumor protein p53	Homo sapiens	108-111
15252778-9	2004	In the setting of ischemic acute renal failure, the administration of L-arginine had a beneficial effect on GFR and RPF, decreased O2- production, diminished up-regulation of soluble guanylate cyclase, and prevented up-regulation of inducible NO synthase (iNOS).	Arginine	70-80	nitric oxide synthase 2	Rattus norvegicus	233-254
15252778-9	2004	In the setting of ischemic acute renal failure, the administration of L-arginine had a beneficial effect on GFR and RPF, decreased O2- production, diminished up-regulation of soluble guanylate cyclase, and prevented up-regulation of inducible NO synthase (iNOS).	Arginine	70-80	nitric oxide synthase 2	Rattus norvegicus	256-260
15286885-3	2004	It is synthesized from L-arginine, which is catalyzed by nitric oxide synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	57-78
15078870-10	2004	In conclusion, Arg(563) and Lys(565) possess distinct roles as carboxylate recognition sites for two chemically different substrates, each of which is turned over in separate enzymatic reactions catalyzed by LTA(4) hydrolase.	Arginine	15-18	leukotriene A4 hydrolase	Homo sapiens	208-224
15066989-1	2004	The catalytic center of nitric-oxide synthase (NOS) consists of a thiolate-coordinated heme macrocycle, a tetrahydrobiopterin (H4B) cofactor, and an l-arginine (l-Arg)/N-hydroxyarginine substrate binding site.	Arginine	149-159	nitric oxide synthase 2	Homo sapiens	24-45
15172174-5	2004	iNOS activation is regulated mainly at the transcriptional level, but also at posttranscriptional, translational and postranslational levels through effects on protein stability, dimerization, phosphorylation, cofactor binding and availability of oxygen and L-arginine as substrates.	Arginine	258-268	nitric oxide synthase 2	Homo sapiens	0-4
15066989-1	2004	The catalytic center of nitric-oxide synthase (NOS) consists of a thiolate-coordinated heme macrocycle, a tetrahydrobiopterin (H4B) cofactor, and an l-arginine (l-Arg)/N-hydroxyarginine substrate binding site.	Arginine	161-166	nitric oxide synthase 2	Homo sapiens	24-45
15095302-2	2004	A selective mutation in TP53 (AGG--&gt;AGT at codon 249, Arg--&gt;Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites.	Arginine	57-60	tumor protein p53	Homo sapiens	24-28
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	kininogen 1	Homo sapiens	0-10
15095302-2	2004	A selective mutation in TP53 (AGG--&gt;AGT at codon 249, Arg--&gt;Ser) has been identified as a hotspot in HCCs from such areas, reflecting DNA damage caused by aflatoxin metabolites.	Arginine	57-60	angiotensinogen	Homo sapiens	39-42
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	87-90	kininogen 1	Homo sapiens	0-10
15189031-0	2004	Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities.	Arginine	129-132	coagulation factor II, thrombin	Homo sapiens	50-58
15189031-2	2004	In this study we have designed and synthesized two series of new thrombin receptor antagonists based on the thrombin receptor motif sequence S42FLLR46, one possessing two (Phe/Arg) pharmacophoric groups and the other possessing three (Phe/Arg/NH2).	Arginine	176-179	coagulation factor II, thrombin	Homo sapiens	65-73
15189031-2	2004	In this study we have designed and synthesized two series of new thrombin receptor antagonists based on the thrombin receptor motif sequence S42FLLR46, one possessing two (Phe/Arg) pharmacophoric groups and the other possessing three (Phe/Arg/NH2).	Arginine	176-179	coagulation factor II, thrombin	Homo sapiens	108-116
15189031-2	2004	In this study we have designed and synthesized two series of new thrombin receptor antagonists based on the thrombin receptor motif sequence S42FLLR46, one possessing two (Phe/Arg) pharmacophoric groups and the other possessing three (Phe/Arg/NH2).	Arginine	239-242	coagulation factor II, thrombin	Homo sapiens	65-73
15189031-2	2004	In this study we have designed and synthesized two series of new thrombin receptor antagonists based on the thrombin receptor motif sequence S42FLLR46, one possessing two (Phe/Arg) pharmacophoric groups and the other possessing three (Phe/Arg/NH2).	Arginine	239-242	coagulation factor II, thrombin	Homo sapiens	108-116
15140517-1	2004	OBJECTIVE: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer.	Arginine	54-57	tumor protein p53	Homo sapiens	39-42
15140517-1	2004	OBJECTIVE: To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer.	Arginine	58-61	tumor protein p53	Homo sapiens	39-42
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	kininogen 1	Homo sapiens	0-10
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	kininogen 1	Homo sapiens	0-10
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	Arginine	146-149	kininogen 1	Homo sapiens	191-201
15040788-6	2004	The proline residue that is two residues upstream of bradykinin in rat kininogen is, in part, responsible for this pattern of hydrolysis, since the peptide Abz-GFSPFRASRVQ-EDDnp was preferentially cleaved at the Arg-Ala bond by hK1.	Arginine	212-215	kininogen 1	Homo sapiens	53-63
15070897-4	2004	Here we provide strong evidence that a physical interaction requiring the kinase domain of Src and the arginine-rich motif of E4orf4 is involved.	Arginine	103-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	91-94
15157181-9	2004	Replacement of three arginine residues (R432, R436 and R440) unique to the HA stretch of the 5-HT3A subunit with the aligned residues (Q395, D399 and A403) of the 5-HT3B subunit increased the single-channel conductance 28-fold.	Arginine	21-29	5-hydroxytryptamine receptor 3A	Homo sapiens	93-99
15096520-4	2004	Here, we have demonstrated that TARPP is arginine-methylated at a single residue, Arg(650), both in vitro and in vivo.	Arginine	41-49	cAMP regulated phosphoprotein 21	Homo sapiens	32-37
15096520-4	2004	Here, we have demonstrated that TARPP is arginine-methylated at a single residue, Arg(650), both in vitro and in vivo.	Arginine	82-85	cAMP regulated phosphoprotein 21	Homo sapiens	32-37
15165856-9	2004	Two alternative conformations of the Arg84(E10) guanidium group were observed, suggesting that it participates in ligand binding to Cgb, as is the case for Arg(E10) of Aplysia Mb and Lys(E10) of Ngb.	Arginine	37-40	cytoglobin	Homo sapiens	132-135
15157086-7	2004	In contrast, UCH-L3 exhibited minor amino acid preferences at P2" " and P4" " and a 10-fold preference for the basic residues Arg and Lys at P3" ".	Arginine	126-129	ubiquitin C-terminal hydrolase L3	Homo sapiens	13-19
15249706-5	2004	The secretory response to L-arginine (5 mM), 25 min after restoring the basal concentration of D-glucose, was more markedly affected, in terms of potentiation of insulin and somatostatin release and reduction of glucagon output, after prior administration of D-fructose than after a prior increase in D-glucose concentration.	Arginine	26-36	somatostatin	Rattus norvegicus	174-186
15255178-4	2004	Cleavage of prohormone processing sites by secretory vesicle cathepsin L occurs at the NH2-terminal side of dibasic residues, as well as between the dibasic residues, resulting in peptide intermediates with Arg or Lys extensions at their NH2-termini.	Arginine	207-210	cathepsin L	Homo sapiens	61-72
15158149-8	2004	Administration of L-arginine 10 min before reperfusion markedly decreased TUNEL-positive staining cardiomyocytes, reduced myocardial caspase-3 activity, inhibited iNOS expression, and reduced myocardial nitrotyrosine content.	Arginine	18-28	nitric oxide synthase 2	Rattus norvegicus	163-167
15158149-9	2004	In strict contrast, administration of L-arginine 3 h after reperfusion, a time point when iNOS was expressed, resulted in a significant increase in myocardial NO(x) content, myocardial injury, and toxic peroxynitrite formation as measured by nitrotyrosine.	Arginine	38-48	nitric oxide synthase 2	Rattus norvegicus	90-94
15158149-10	2004	CONCLUSION: Our results demonstrated for the first time that L-arginine administered at different time points during ischemia/reperfusion exerted different effects on post-ischemic myocardial injury, and suggests that stimulation of eNOS reduces nitrative stress and decreases apoptosis whereas stimulation of iNOS increases nitrative stress and enhances myocardial reperfusion injury.	Arginine	61-71	nitric oxide synthase 2	Rattus norvegicus	310-314
15144861-1	2004	The inducible isoform of nitric oxide synthase (iNOS), produces nitric oxide (NO) from l-arginine in response to inflammatory stimuli.	Arginine	87-97	nitric oxide synthase 2	Rattus norvegicus	48-52
15145278-1	2004	OBJECTIVES: Although some studies have reported that the arginine isoform on codon 72 of p53 increases the susceptibility to invasive cervical cancer, such data remain controversial.	Arginine	57-65	tumor protein p53	Homo sapiens	89-92
15182369-5	2004	The APMA-stimulated secretase cleaved ACE at the same Arg-Ser bond in the juxtamembrane stalk as the constitutive secretase but was more sensitive to inhibition by a hydroxamate-based compound.	Arginine	54-57	angiotensin I converting enzyme	Homo sapiens	38-41
15105048-3	2004	The p53 gene displays a common genetic Arg/Pro polymorphism at codon 72 with functional significance, that has been investigated as risk factor in several cancer models.	Arginine	39-42	tumor protein p53	Homo sapiens	4-7
15169881-9	2004	Mutation of arginine 78 of SAP, a residue critical for binding of SAP to FynT, eliminated 2B4-mediated protein tyrosine phosphorylation, implying that SAP promotes 2B4 signaling most probably by recruiting FynT.	Arginine	12-20	SH2 domain containing 1A	Homo sapiens	27-30
15169881-9	2004	Mutation of arginine 78 of SAP, a residue critical for binding of SAP to FynT, eliminated 2B4-mediated protein tyrosine phosphorylation, implying that SAP promotes 2B4 signaling most probably by recruiting FynT.	Arginine	12-20	SH2 domain containing 1A	Homo sapiens	66-69
15169881-9	2004	Mutation of arginine 78 of SAP, a residue critical for binding of SAP to FynT, eliminated 2B4-mediated protein tyrosine phosphorylation, implying that SAP promotes 2B4 signaling most probably by recruiting FynT.	Arginine	12-20	SH2 domain containing 1A	Homo sapiens	66-69
15084609-0	2004	Arginine methylation of RNA helicase a determines its subcellular localization.	Arginine	0-8	DExH-box helicase 9	Homo sapiens	24-38
15084609-6	2004	Removal of the arginine-rich C-terminal region negates the effects of the methylation inhibitors on NTD import, suggesting that methylation of the NTD C terminus the relieves the cytoplasmic retention of RHA.	Arginine	15-23	DExH-box helicase 9	Homo sapiens	204-207
15084609-8	2004	These findings provide evidence for a novel arginine methylation-dependent regulatory pathway controlling the nuclear import of RHA.	Arginine	44-52	DExH-box helicase 9	Homo sapiens	128-131
15044467-3	2004	We have previously suggested that the C-terminal processing of EC-SOD is either a one-step mechanism accomplished by a single intracellular endoproteolytic event cleaving the Glu(209)-Arg(210) peptide bond or a two-step mechanism involving two proteinases (Enghild, J. J., Thogersen, I.	Arginine	184-187	superoxide dismutase 3	Homo sapiens	63-69
15185439-2	2004	the mutations responsible are located in the CACNA1S gene (type 1) and in the SCN4A gene (type 2), and are all missense mutations where arginine is mostly replaced by histidine or sometimes glycine.	Arginine	136-144	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	45-52
15717658-5	2004	The analysis revealed a heterozygous mutation in exon 4 of the MEN 1 gene: a G to A missense mutation at codon 229 (CGC--&gt;CAC), which changes arginine to histidine.	Arginine	145-153	menin 1	Homo sapiens	63-68
15140957-4	2004	Deletions of cytoplasmic sequences or mutations of the Tyr-Thr-Arg-Phe internalization motif reduced the rate of receptor uptake from the cell surface, while polar residues introduced into the transmembrane sequence resulted in increased degradation of transferrin.	Arginine	63-66	transferrin	Homo sapiens	253-264
15157743-2	2004	A comparison of the amino acid sequence for MGST1 revealed one difference in exon 2 between the 129/SvJ strain (arginine at position 5) and the sequence previously reported for the Balb/c strain (lysine).	Arginine	112-120	microsomal glutathione S-transferase 1	Mus musculus	44-49
15134514-4	2004	The search for these compounds is based on the molecular design of structures mimicking some fragment of RGD (Arg-Gly-Asp) sequence, responsible for the binding of fibrinogen to GP IIb/IIIa.	Arginine	110-113	fibrinogen beta chain	Homo sapiens	164-174
14695118-0	2004	Pertussis toxin activates L-arginine uptake in pulmonary endothelial cells through downregulation of PKC-alpha activity.	Arginine	26-36	protein kinase C alpha	Homo sapiens	101-110
14695118-7	2004	An activator of PKC-alpha, phorbol 12-myristate 13-acetate, abrogated the activation of l-arginine transport in PAEC treated with PTX.	Arginine	88-98	protein kinase C alpha	Homo sapiens	16-25
14695118-8	2004	Incubation of PTX-treated PAEC with phorbol 12-myristate 13-acetate in combination with an inhibitor of PKC-alpha (Go 6976) restored the activating effects of PTX on l-arginine uptake, suggesting PTX-induced activation of l-arginine transport is mediated through downregulation of PKC-alpha.	Arginine	166-176	protein kinase C alpha	Homo sapiens	104-113
14695118-8	2004	Incubation of PTX-treated PAEC with phorbol 12-myristate 13-acetate in combination with an inhibitor of PKC-alpha (Go 6976) restored the activating effects of PTX on l-arginine uptake, suggesting PTX-induced activation of l-arginine transport is mediated through downregulation of PKC-alpha.	Arginine	166-176	protein kinase C alpha	Homo sapiens	281-290
14695118-8	2004	Incubation of PTX-treated PAEC with phorbol 12-myristate 13-acetate in combination with an inhibitor of PKC-alpha (Go 6976) restored the activating effects of PTX on l-arginine uptake, suggesting PTX-induced activation of l-arginine transport is mediated through downregulation of PKC-alpha.	Arginine	222-232	protein kinase C alpha	Homo sapiens	104-113
15161530-6	2004	METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to find mEH polymorphism in exon 3 (Tyr113--&gt;His), exon 4 (His139--&gt;Arg) and GSTP1 polymorphism in exon 5 (Ile105--&gt;Val) in 100 COPD patients and 100 age- and sex-matched healthy controls.	Arginine	175-178	epoxide hydrolase 1, microsomal	Mus musculus	109-112
15121191-2	2004	To develop more gentle conditions of perhaps general use, we used as a model for study the oxygenase domain of murine inducible nitric oxide synthase (iNOS), which is homodimeric, binds heme and tetrahydrobiopterin H(4)B cofactors, and the substrate L-arginine.	Arginine	250-260	nitric oxide synthase 2, inducible	Mus musculus	118-149
15029234-4	2004	Sequence analysis showed an increased frequency of DR beta-Arg-74 in GD patients compared to controls (41.8 and 13.4%, respectively; P=2.3 x 10(-8), OR=4.6).	Arginine	59-62	solute carrier family 26 member 3	Homo sapiens	51-58
15029234-5	2004	Moreover, subset analyses showed that DR beta-Arg-74 was also significantly more frequent in the HLA-DR3 negative GD patients than in controls (7.6 vs 0.8%, P=0.02, OR=10.5), suggesting that the association with DR beta-Arg-74 is independent of the association with HLA-DR3.	Arginine	46-49	solute carrier family 26 member 3	Homo sapiens	38-45
15029234-5	2004	Moreover, subset analyses showed that DR beta-Arg-74 was also significantly more frequent in the HLA-DR3 negative GD patients than in controls (7.6 vs 0.8%, P=0.02, OR=10.5), suggesting that the association with DR beta-Arg-74 is independent of the association with HLA-DR3.	Arginine	46-49	solute carrier family 26 member 3	Homo sapiens	212-219
15029234-5	2004	Moreover, subset analyses showed that DR beta-Arg-74 was also significantly more frequent in the HLA-DR3 negative GD patients than in controls (7.6 vs 0.8%, P=0.02, OR=10.5), suggesting that the association with DR beta-Arg-74 is independent of the association with HLA-DR3.	Arginine	220-223	solute carrier family 26 member 3	Homo sapiens	38-45
15341188-1	2004	Nitric oxide (NO) is a key bioregulatory active molecule in the cardiovascular, immune and nervous systems, synthesized through converting L-arginine to L-citrulline by NO synthase (NOS).	Arginine	139-149	nitric oxide synthase 2	Homo sapiens	169-180
15111485-10	2004	First-phase insulin response and the insulin response to an arginine stimulation test with the presence of hyperglycemia were markedly increased (P &lt; 0.001), whereas the proinsulin/insulin ratio fell (P = 0.001).	Arginine	60-68	insulin	Homo sapiens	37-44
15111485-10	2004	First-phase insulin response and the insulin response to an arginine stimulation test with the presence of hyperglycemia were markedly increased (P &lt; 0.001), whereas the proinsulin/insulin ratio fell (P = 0.001).	Arginine	60-68	insulin	Homo sapiens	37-44
15099969-2	2004	In this regard, genetic polymorphism at codon 72 (CCC/proline to CGC/arginine [Pro(72)Arg]) of the p53 gene is one of the most frequently studied subjects.	Arginine	69-77	tumor protein p53	Homo sapiens	99-102
15099969-3	2004	An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser(31)Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported.	Arginine	94-102	tumor protein p53	Homo sapiens	180-183
15126527-2	2004	It is due to postzygotic activating mutations of arginine 201 in the guanine-nucleotide-binding protein (G protein) alpha-subunit (Gsalpha), leading to a mosaic distribution of cells bearing constitutively active adenylate cyclase.	Arginine	49-57	GNAS complex locus	Homo sapiens	131-138
15121191-2	2004	To develop more gentle conditions of perhaps general use, we used as a model for study the oxygenase domain of murine inducible nitric oxide synthase (iNOS), which is homodimeric, binds heme and tetrahydrobiopterin H(4)B cofactors, and the substrate L-arginine.	Arginine	250-260	nitric oxide synthase 2, inducible	Mus musculus	151-155
15121191-5	2004	Under gentle source collision conditions, and using multiple low-energy collisions in the collision cell of the mass spectrometer, dimers of the iNOS oxygenase domain containing heme, H(4)B, and arginine were observed intact after electrospraying at pH values near neutrality; a mutant of this protein (Trp188 --&gt; Phe) was monomeric and did not bind cofactors.	Arginine	195-203	nitric oxide synthase 2, inducible	Mus musculus	145-149
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Arginine	30-33	tumor protein p53	Homo sapiens	50-53
15105550-3	2004	We have demonstrated that amino acids (aa) 108-122 of the GRV ORF3 protein contain an arginine-rich nuclear localization signal.	Arginine	86-94	hypothetical protein	Groundnut rosette virus	62-66
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Arginine	39-42	tumor protein p53	Homo sapiens	50-53
15216398-9	2004	The frequency of pro/pro, pro/arg, and arg/arg in p53 codon 72 in cases was 15% (15/99), 58% (57/99), and 27% (27/99) and in controls was 17% (34/193), 48% (92/193), and 35% (67/193), respectively, which was not significantly different.	Arginine	39-42	tumor protein p53	Homo sapiens	50-53
15118362-9	2004	These results suggest that protein methylation activates RyR/Ca(2+) release channels and may participate in the control of intracellular Ca(2+) mobilization in CASM cells by transferring a methyl group to the arginine moiety of the RyR accessory protein, FKBP 12.	Arginine	209-217	ryanodine receptor 1	Homo sapiens	57-60
15118362-9	2004	These results suggest that protein methylation activates RyR/Ca(2+) release channels and may participate in the control of intracellular Ca(2+) mobilization in CASM cells by transferring a methyl group to the arginine moiety of the RyR accessory protein, FKBP 12.	Arginine	209-217	ryanodine receptor 1	Homo sapiens	232-235
14970225-1	2004	Human tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type proteinase inhibitor that regulates a variety of serine proteinases involved in coagulation and fibrinolysis through their non-productive interaction with a P(1) residue (Arg-24) in its first Kunitz-type domain (KD1).	Arginine	237-240	tissue factor pathway inhibitor 2	Homo sapiens	6-39
15319801-7	2004	However, Hoe 140 D-Arg-[Hyp3, Thi5,D-Tic7, Oic8]-bradykinin, an antagonist of B2 responses, significantly inhibited bradykinin-induced contraction.	Arginine	19-22	kininogen 1	Homo sapiens	49-59
15319801-7	2004	However, Hoe 140 D-Arg-[Hyp3, Thi5,D-Tic7, Oic8]-bradykinin, an antagonist of B2 responses, significantly inhibited bradykinin-induced contraction.	Arginine	19-22	kininogen 1	Homo sapiens	116-126
15069555-2	2004	The p53 codon 72 Arg right curved arrow Pro polymorphism has been suggested to be associated with risk for different kind of cancers, but the data on gastric cancer (GC) is very limited.	Arginine	17-20	tumor protein p53	Homo sapiens	4-7
15069555-5	2004	The frequency of the p53 Arg allele was 57.4% in the cases and 54.9% in the controls, and the genotype frequencies of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 29.6%, 55.6%, and 14.8%, respectively, in the cases, and 29.6%, 50.5%, and 19.9%, respectively, in the controls (p=0.207).	Arginine	25-28	tumor protein p53	Homo sapiens	21-24
15069555-5	2004	The frequency of the p53 Arg allele was 57.4% in the cases and 54.9% in the controls, and the genotype frequencies of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 29.6%, 55.6%, and 14.8%, respectively, in the cases, and 29.6%, 50.5%, and 19.9%, respectively, in the controls (p=0.207).	Arginine	122-125	tumor protein p53	Homo sapiens	118-121
15069555-5	2004	The frequency of the p53 Arg allele was 57.4% in the cases and 54.9% in the controls, and the genotype frequencies of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 29.6%, 55.6%, and 14.8%, respectively, in the cases, and 29.6%, 50.5%, and 19.9%, respectively, in the controls (p=0.207).	Arginine	122-125	tumor protein p53	Homo sapiens	118-121
15069555-5	2004	The frequency of the p53 Arg allele was 57.4% in the cases and 54.9% in the controls, and the genotype frequencies of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 29.6%, 55.6%, and 14.8%, respectively, in the cases, and 29.6%, 50.5%, and 19.9%, respectively, in the controls (p=0.207).	Arginine	122-125	tumor protein p53	Homo sapiens	118-121
15194361-1	2004	Various brief metabolic tests have been proposed as surrogate measures of insulin secretory reserve, which is normally determined by the more complicated and labor-intensive method of glucose potentiation of arginine-induced insulin secretion (GPAIS).	Arginine	208-216	insulin	Homo sapiens	74-81
15194361-2	2004	This article provides correlations between insulin responses to intravenous arginine (AIRarg) and intravenous glucose (AIRgluc) in 39 normal control subjects in whom insulin secretory reserve was measured by GPAIS.	Arginine	76-84	insulin	Homo sapiens	43-50
14966128-5	2004	Examination of a series of wild type and mutant Stat3 proteins demonstrated loss of binding to pYXXQ-containing peptides only in Stat3 mutated at Lys-591 or Arg-609, whose side chains interact with the Tyr(P) residue, and Stat3 mutated at Glu-638, whose amide hydrogen bonds with oxygen within the +3 Gln side chain when the peptide ligand assumes a beta-turn.	Arginine	157-160	signal transducer and activator of transcription 3	Homo sapiens	48-53
15131772-7	2004	However, in 327 subjects with normal glucose tolerance (NGT), the subjects with Arg/Gln or Gln/Gln + A/A haplotype showed significantly higher serum insulin levels and homeostasis model assessment (HOMA) index than those with Arg/Arg + A/A haplotype and Arg/Gln or Gln/Gln + A/G or G/G haplotype.	Arginine	80-83	insulin	Homo sapiens	149-156
15131772-7	2004	However, in 327 subjects with normal glucose tolerance (NGT), the subjects with Arg/Gln or Gln/Gln + A/A haplotype showed significantly higher serum insulin levels and homeostasis model assessment (HOMA) index than those with Arg/Arg + A/A haplotype and Arg/Gln or Gln/Gln + A/G or G/G haplotype.	Arginine	226-229	insulin	Homo sapiens	149-156
15131772-7	2004	However, in 327 subjects with normal glucose tolerance (NGT), the subjects with Arg/Gln or Gln/Gln + A/A haplotype showed significantly higher serum insulin levels and homeostasis model assessment (HOMA) index than those with Arg/Arg + A/A haplotype and Arg/Gln or Gln/Gln + A/G or G/G haplotype.	Arginine	226-229	insulin	Homo sapiens	149-156
15096035-8	2004	The catalytic and structural role of His41 is consistent with the observation that the mutation of His43 in human SOD (equivalent to His41 in bovine SOD) to Arg largely reduces the dismutase activity and the protein structural stability.	Arginine	157-160	superoxide dismutase 1	Homo sapiens	114-117
15096035-8	2004	The catalytic and structural role of His41 is consistent with the observation that the mutation of His43 in human SOD (equivalent to His41 in bovine SOD) to Arg largely reduces the dismutase activity and the protein structural stability.	Arginine	157-160	superoxide dismutase 1	Homo sapiens	149-152
14970225-1	2004	Human tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type proteinase inhibitor that regulates a variety of serine proteinases involved in coagulation and fibrinolysis through their non-productive interaction with a P(1) residue (Arg-24) in its first Kunitz-type domain (KD1).	Arginine	237-240	tissue factor pathway inhibitor 2	Homo sapiens	41-47
15077186-1	2004	A single-nucleotide polymorphism (SNP) in exon 4 results in expression of either arginine (72R) or proline (72P) at codon 72 of p53.	Arginine	81-89	tumor protein p53	Homo sapiens	128-131
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Arginine	157-165	FUS RNA binding protein	Homo sapiens	37-40
15066430-6	2004	Modelling of the C-terminal part of the natural substrate Arg(6)-Met-enkephalin into the active site shows that the S1" pocket of CPM is particularly well designed to accommodate P1"-Arg residues, in agreement with the preference of CPM for cleaving C-terminal Arg.	Arginine	58-61	proopiomelanocortin	Homo sapiens	65-79
15066430-6	2004	Modelling of the C-terminal part of the natural substrate Arg(6)-Met-enkephalin into the active site shows that the S1" pocket of CPM is particularly well designed to accommodate P1"-Arg residues, in agreement with the preference of CPM for cleaving C-terminal Arg.	Arginine	183-186	proopiomelanocortin	Homo sapiens	65-79
15066430-6	2004	Modelling of the C-terminal part of the natural substrate Arg(6)-Met-enkephalin into the active site shows that the S1" pocket of CPM is particularly well designed to accommodate P1"-Arg residues, in agreement with the preference of CPM for cleaving C-terminal Arg.	Arginine	183-186	proopiomelanocortin	Homo sapiens	65-79
14759560-1	2004	Previous modeling (PDB 1cfk) of the catecholamine release-inhibitory "catestatin" region of chromogranin A (CgA) suggested a beta-strand/loop/beta-strand active conformation, displaying an electropositive Arg-rich loop (R(351)AR(353)GYGFR(358)).	Arginine	205-208	chromogranin A	Homo sapiens	92-106
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Arginine	31-34	agouti related neuropeptide	Mus musculus	72-76
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Arginine	77-80	agouti related neuropeptide	Mus musculus	72-76
14759554-11	2004	The V1 receptor antagonist of vasopressin (B-mercapto B, B-cyclopentamethylenepropionyl, O-Me-Tyr,Arg)-vasopressin (10 microg/kg), that was applied intraarterially, only prevented the effect of GLP-1 on blood pressure, but did not show any effect on heart rate.	Arginine	98-101	arginine vasopressin	Rattus norvegicus	103-114
15084118-9	2004	In these chimeric ligands, the antagonist AGRP Arg-Phe-Phe residues were replaced by the melanocortin agonist His/D-Phe-Arg-Trp amino acids.	Arginine	47-50	agouti related neuropeptide	Mus musculus	42-46
14759560-1	2004	Previous modeling (PDB 1cfk) of the catecholamine release-inhibitory "catestatin" region of chromogranin A (CgA) suggested a beta-strand/loop/beta-strand active conformation, displaying an electropositive Arg-rich loop (R(351)AR(353)GYGFR(358)).	Arginine	205-208	chromogranin A	Homo sapiens	108-111
14726521-8	2004	Mutagenesis of the basic amino acid Arg(537) in the protease cleavage region, as suggested by mass spectrometry, abrogated both the androgen-induced accumulation of the 60-kDa product and decrease in cell death induced by FKHR, suggesting that the residue Arg(537) is a potential protease cleavage site.	Arginine	36-39	forkhead box O1	Homo sapiens	222-226
14726518-4	2004	We previously reported that the mutation of specific residues in the S4-S5 linker of HCN2 (i.e. Tyr-331 and Arg-339) prevented normal channel closure presumably by disruption of a crucial interaction with the activation gate.	Arginine	108-111	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	85-89
15041222-4	2004	The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro).	Arginine	82-90	tumor protein p53	Homo sapiens	4-8
15039212-0	2004	Retention of the arginine allele in codon 72 of the p53 gene correlates with poor apoptosis in head and neck cancer.	Arginine	17-25	tumor protein p53	Homo sapiens	52-55
15039212-9	2004	p53 mutations were detected in 29.6% of SCCHN and preferentially occurred at the arginine allele (P = 0.01).	Arginine	81-89	tumor protein p53	Homo sapiens	0-3
15041222-4	2004	The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro).	Arginine	92-95	tumor protein p53	Homo sapiens	4-8
15007014-1	2004	BACKGROUND: Nitric oxide synthase (NOS) uses arginine for the production of nitric oxide (NO).	Arginine	45-53	nitric oxide synthase 2	Homo sapiens	12-33
15042126-10	2004	Patients who were in the highest quartile of plasma arginine concentrations had significantly lower fibrinogen concentrations, higher lactic acid concentrations, and longer prothrombin time.	Arginine	52-60	fibrinogen beta chain	Homo sapiens	100-110
15039546-6	2004	The other recombinant CP enabled virus movement only after the introduction of two point mutations (Glu--&gt;Lys and Lys--&gt;Arg at aa 62 and 65, respectively).	Arginine	126-129	golgi phosphoprotein 3	Homo sapiens	22-24
15035617-0	2004	Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone.	Arginine	27-35	parathyroid hormone	Homo sapiens	106-125
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone	Homo sapiens	67-70
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone	Homo sapiens	88-91
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone	Homo sapiens	88-91
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone	Homo sapiens	88-91
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone	Homo sapiens	67-70
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone	Homo sapiens	88-91
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone	Homo sapiens	88-91
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone	Homo sapiens	88-91
15010853-4	2004	l-Arginine and l-Leucine induced activation of p70 S6 kinase and phosphorylation of 4E-BP1 in a rapamycin-sensitive manner, which suggested the involvement of mTOR signaling pathway in these effects.	Arginine	0-10	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	84-90
15010853-7	2004	In conclusion, l-Arginine regulates p70 S6 kinase activity and phosphorylation of 4E-BP1 through mTOR signaling pathway, which involves system y(+), cationic amino acid transporters.	Arginine	15-25	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	82-88
15198291-6	2004	GH levels were measured in patients with SCD with and without growth failure using arginine and L-Dopa as provocative stimulation tests.	Arginine	83-91	growth hormone 1	Homo sapiens	0-2
14978285-6	2004	Among residues constituting the interface, Phe-34, Ser-36A, Leu-65, Tyr-76, Arg-77A, Ile-82, and Lys-110 of thrombin and the A alpha chain Trp-33, Phe-35, Asp-38, Glu-39, the B beta chain Ala-68 and Asp-69, and the gamma chain Asp-27 and Ser-30 of E(ht) form a net of polar contacts surrounding a well defined hydrophobic interior.	Arginine	76-79	coagulation factor II, thrombin	Homo sapiens	108-116
14679197-1	2004	Residue Asp-189 plays an important dual role in thrombin: it defines the primary specificity for Arg side chains and participates indirectly in the coordination of Na(+).	Arginine	97-100	coagulation factor II, thrombin	Homo sapiens	48-56
14613894-1	2004	Nitric oxide (NO), synthesized from l-arginine by NO synthase (NOS), is a key regulator of placental angiogenesis and growth during pregnancy.	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	50-61
14982563-2	2004	Type-2 cationic amino acid transporter (CAT-2) mediation of trans-membrane L-arginine (L-Arg) transportation has been identified as one of the crucial regulatory mechanisms involved in the formation of NO by iNOS.	Arginine	75-85	nitric oxide synthase 2	Rattus norvegicus	208-212
14982563-2	2004	Type-2 cationic amino acid transporter (CAT-2) mediation of trans-membrane L-arginine (L-Arg) transportation has been identified as one of the crucial regulatory mechanisms involved in the formation of NO by iNOS.	Arginine	87-92	nitric oxide synthase 2	Rattus norvegicus	208-212
14988247-7	2004	2) Do recipients who have no AIR(gluc) have an acute insulin response to intravenous arginine (AIR(arg))?	Arginine	85-93	insulin	Homo sapiens	53-60
14988247-7	2004	2) Do recipients who have no AIR(gluc) have an acute insulin response to intravenous arginine (AIR(arg))?	Arginine	85-88	insulin	Homo sapiens	53-60
15006455-8	2004	l-Arginine (100 mg/kg ip) significantly antagonised the effects of l-NAME (50 microg), 3,4-DAP and TEA.	Arginine	0-10	death-associated protein	Mus musculus	91-94
14744923-9	2004	In normal placenta, adequate concentration of l-arginine orients ecNOS toward NO.	Arginine	46-56	nitric oxide synthase 3	Homo sapiens	65-70
14744923-10	2004	In preeclampsia, a lower than normal l-arginine concentration caused by arginase II overexpression redirects ecNOS toward peroxynitrite.	Arginine	37-47	nitric oxide synthase 3	Homo sapiens	109-114
15136972-0	2004	Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes.	Arginine	81-91	angiotensin I converting enzyme	Homo sapiens	11-14
15136972-2	2004	However, the potential of ACE inhibitors (ACE-I) to enhance the haemodynamic effects of L-arginine (L-arg), the precursor of nitric oxide (NO), has not been evaluated.	Arginine	88-98	angiotensin I converting enzyme	Homo sapiens	26-29
15136972-2	2004	However, the potential of ACE inhibitors (ACE-I) to enhance the haemodynamic effects of L-arginine (L-arg), the precursor of nitric oxide (NO), has not been evaluated.	Arginine	88-98	angiotensin I converting enzyme	Homo sapiens	42-45
15136972-2	2004	However, the potential of ACE inhibitors (ACE-I) to enhance the haemodynamic effects of L-arginine (L-arg), the precursor of nitric oxide (NO), has not been evaluated.	Arginine	88-93	angiotensin I converting enzyme	Homo sapiens	26-29
15136972-2	2004	However, the potential of ACE inhibitors (ACE-I) to enhance the haemodynamic effects of L-arginine (L-arg), the precursor of nitric oxide (NO), has not been evaluated.	Arginine	88-93	angiotensin I converting enzyme	Homo sapiens	42-45
15136972-12	2004	CONCLUSIONS: ACE-Is have greater potential than ARBs to enhance L-arg effects in the kidney in uncomplicated Type 1 diabetes.	Arginine	64-69	angiotensin I converting enzyme	Homo sapiens	13-16
15136972-14	2004	The lack of changes in renal NO indicators parallelling the haemodynamic responses, suggests that the effects of ACE-I on L-arg-induced renal haemodynamic changes could be also attributable to NO-independent mechanisms.	Arginine	122-127	angiotensin I converting enzyme	Homo sapiens	113-116
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	Janus kinase 1	Homo sapiens	70-74
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	protein kinase C alpha	Homo sapiens	153-161
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	178-183
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	signal transducer and activator of transcription 3	Homo sapiens	255-260
15039778-7	2004	Genetic or pharmacological interference with Abl (and the related kinase Arg) resulted in a marked decrease in Rac activation induced by physiological doses of growth factors.	Arginine	73-76	AKT serine/threonine kinase 1	Homo sapiens	111-114
15051174-1	2004	The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine surrogate are described.	Arginine	190-198	coagulation factor II, thrombin	Homo sapiens	106-114
15052603-7	2004	Administration of 100 mg kg(-1) l-arginine for 7 days either before or after alloxan injection significantly ameliorated the oxidative stress evidenced by a lower TBARS and a higher level of the endogenous GSH concentration and SOD and CAT activities than alloxan-treated rats.	Arginine	32-42	catalase	Rattus norvegicus	236-239
15027030-9	2004	In addition we found that peptides corresponding to the Arg(255)-Ser(267), Lys(288)-Ser(298) or Pro(230)-Val(240) when presented in a multimeric form conjugated to branched chain polypeptide in uniformly oriented copies induced the release of TNFalpha, a pro-inflammatory cytokine from MonoMac monocyte cell line.	Arginine	56-59	tumor necrosis factor	Homo sapiens	243-251
14993293-2	2004	Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl.	Arginine	38-41	phospholipase C gamma 1	Homo sapiens	124-146
14993293-2	2004	Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl.	Arginine	38-41	phospholipase C gamma 1	Homo sapiens	148-158
14993293-4	2004	We now demonstrate that c-Abl and Arg form inducible complexes with and are phosphorylated by the PDGFR tyrosine kinase in vitro and in vivo.	Arginine	34-37	platelet derived growth factor receptor beta	Homo sapiens	98-103
14993293-5	2004	Moreover, c-Abl and Arg, in turn, phosphorylate the PDGFR.	Arginine	20-23	platelet derived growth factor receptor beta	Homo sapiens	52-57
14993293-6	2004	We show that c-Abl and Arg exhibit nonredundant functions downstream of the activated PDGFR.	Arginine	23-26	platelet derived growth factor receptor beta	Homo sapiens	86-91
15135362-6	2004	L-Arginine (1 and 2 mM) was able to mimic IL-1beta actions and the NOS blocker L-Nitro-Arginin-Methyl Ester reverted these effects.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	42-50
14970387-7	2004	These studies indicate that the Tat arginine-rich motif, in addition to its known binding site at the bulge, is in close contact with U31 in the TAR loop.	Arginine	36-44	RNA binding motif protein 8A	Homo sapiens	145-148
15002755-6	2004	Also L-arginine inhibited the elevation of plasma endothelin-1 (P&lt;0.01).	Arginine	5-15	endothelin 1	Rattus norvegicus	50-62
15006455-9	2004	Higher dose of l-arginine (500 mg/kg ip) significantly potentiated the effects of 3,4-DAP and TEA, but reduced the effect of pinacidil.	Arginine	15-25	death-associated protein	Mus musculus	86-89
15264124-1	2004	Arginine has been used by millions of athletes over the past 20 years to enhance production of human growth hormone.	Arginine	0-8	growth hormone 1	Homo sapiens	101-115
14996197-0	2004	Deletion of arginine codon 229 in the Rhce gene alters e and f but not c antigen expression.	Arginine	12-20	Rh blood group CcEe antigens	Homo sapiens	38-42
14996197-11	2004	RT-PCR detected a triplet deletion (Delta685AGA687) in the Rhce gene that specifies codon 229 for arginine (Arg229).	Arginine	98-106	Rh blood group CcEe antigens	Homo sapiens	59-63
14660664-8	2004	First, unlike villin headpiece that contains a single buried salt bridge, DHP contains a buried charged cluster comprising residues Glu(39), Arg(66), Lys(70), and the C-terminal carboxylate of Phe(76).	Arginine	141-144	dihydropyrimidinase	Homo sapiens	74-77
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Arginine	172-175	TATA-box binding protein like 1	Homo sapiens	116-119
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Arginine	200-203	TATA-box binding protein like 1	Homo sapiens	116-119
14729396-0	2004	Structure-activity relationship of synthetic truncated analogues of vasoactive intestinal peptide (VIP): an enhancement in the activity by a substitution with arginine.	Arginine	159-167	vasoactive intestinal polypeptide	Mus musculus	68-97
14766200-1	2004	Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an enzyme that metabolizes methylated arginine to citrulline and methylamine, thus working to produce nitric oxide (NO).	Arginine	8-16	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	43-48
14602725-9	2004	Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media.	Arginine	78-88	mitogen-activated protein kinase 3	Homo sapiens	141-147
14729396-7	2004	In conclusion, it was shown that [Arg(15, 20, 21), Leu(17)]-VIP(1-23) could be a relatively potent and stable agonist of VIP receptors.	Arginine	34-37	vasoactive intestinal polypeptide	Mus musculus	60-63
14729396-0	2004	Structure-activity relationship of synthetic truncated analogues of vasoactive intestinal peptide (VIP): an enhancement in the activity by a substitution with arginine.	Arginine	159-167	vasoactive intestinal polypeptide	Mus musculus	99-102
14729396-7	2004	In conclusion, it was shown that [Arg(15, 20, 21), Leu(17)]-VIP(1-23) could be a relatively potent and stable agonist of VIP receptors.	Arginine	34-37	vasoactive intestinal polypeptide	Mus musculus	121-124
14602725-9	2004	Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media.	Arginine	121-131	mitogen-activated protein kinase 3	Homo sapiens	141-147
14729396-6	2004	The chemical modification of VIP(1-23) generated a potent analogue, [Arg(15, 20, 21), Leu(17)]-VIP(1-23), that displayed a 22-fold higher receptor binding activity and 1.6-fold more potent relaxation of mouse stomach than VIP(1-23) did.	Arginine	69-72	vasoactive intestinal polypeptide	Mus musculus	29-32
14602725-10	2004	These findings indicate that nNOS can differentially regulate the ERK signal transduction pathway in a manner dependent on the presence of l-arginine and the production of NO*.	Arginine	139-149	mitogen-activated protein kinase 1	Homo sapiens	66-69
14729396-6	2004	The chemical modification of VIP(1-23) generated a potent analogue, [Arg(15, 20, 21), Leu(17)]-VIP(1-23), that displayed a 22-fold higher receptor binding activity and 1.6-fold more potent relaxation of mouse stomach than VIP(1-23) did.	Arginine	69-72	vasoactive intestinal polypeptide	Mus musculus	95-98
14729396-6	2004	The chemical modification of VIP(1-23) generated a potent analogue, [Arg(15, 20, 21), Leu(17)]-VIP(1-23), that displayed a 22-fold higher receptor binding activity and 1.6-fold more potent relaxation of mouse stomach than VIP(1-23) did.	Arginine	69-72	vasoactive intestinal polypeptide	Mus musculus	95-98
14991378-1	2004	There is a reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways.	Arginine	80-90	nitric oxide synthase 2	Homo sapiens	49-70
14738489-0	2004	A codon 31ser-arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma.	Arginine	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	38-43
14738489-0	2004	A codon 31ser-arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma.	Arginine	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-49
14738489-0	2004	A codon 31ser-arg polymorphism of the WAF-1/CIP-1/p21/tumour suppressor gene in Chinese primary open-angle glaucoma.	Arginine	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-53
14738489-7	2004	The Arg allele of the p21 codon 31 polymorphism was more frequently found in POAG patients than in healthy individuals (odds ratio: 2.389, 95% confidence interval: 1.14-5.01).	Arginine	4-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-25
14738489-8	2004	CONCLUSION: This study suggests that an association exists between the Arg allele of the p21 codon 31 polymorphism and POAG in the Chinese population.	Arginine	71-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-92
14594797-0	2004	Arginine 445 controls the coupling between glutamate and cations in the neuronal transporter EAAC-1.	Arginine	0-8	solute carrier family 1 member 1	Homo sapiens	93-99
14762010-0	2004	ArgR and AhrC are both required for regulation of arginine metabolism in Lactococcus lactis.	Arginine	50-58	arginine repressor	Escherichia coli	0-4
14762010-1	2004	The DNA binding proteins ArgR and AhrC are essential for regulation of arginine metabolism in Escherichia coli and Bacillus subtilis, respectively.	Arginine	71-79	arginine repressor	Escherichia coli	25-29
14762010-7	2004	The three arginine biosynthetic operons argCJDBF, argGH, and gltS-argE were shown to be repressed by the products of argR and ahrC.	Arginine	10-18	arginine repressor	Escherichia coli	117-121
14762010-8	2004	Furthermore, the arginine catabolic arcABD1C1C2TD2 operon was activated by the product of ahrC but not by that of argR.	Arginine	17-25	arginine repressor	Escherichia coli	114-118
14581476-5	2004	In vitro experiments performed at neutral pH showed that papain-like cathepsins B, H, L, S, and K cleave Bid predominantly at Arg(65) or Arg(71).	Arginine	126-129	BH3 interacting domain death agonist	Homo sapiens	105-108
14581476-5	2004	In vitro experiments performed at neutral pH showed that papain-like cathepsins B, H, L, S, and K cleave Bid predominantly at Arg(65) or Arg(71).	Arginine	137-140	BH3 interacting domain death agonist	Homo sapiens	105-108
14707412-9	2004	Stepwise multiple linear regression analysis showed a significant association of enhanced L-arginine reactivity with previous stroke/TIA (p &lt; 0.001) and elevated fibrinogen levels (p &lt; 0.05) but not with age, IMT, hypertension, cholesterol or other risk factors.	Arginine	90-100	fibrinogen beta chain	Homo sapiens	165-175
14583623-3	2004	Here, we demonstrate that the human FIB N-terminal glycine- and arginine-rich domain (residues 1-77) and its spacer region 1 (78-132) interact with splicing factor 2-associated p32 (SF2A-p32) and that the FIB methyltransferase-like domain (133-321) interacts with protein-arginine methyltransferase 5 (PRMT5, Janus kinase-binding protein 1).	Arginine	64-72	protein arginine methyltransferase 5	Homo sapiens	264-300
14583623-3	2004	Here, we demonstrate that the human FIB N-terminal glycine- and arginine-rich domain (residues 1-77) and its spacer region 1 (78-132) interact with splicing factor 2-associated p32 (SF2A-p32) and that the FIB methyltransferase-like domain (133-321) interacts with protein-arginine methyltransferase 5 (PRMT5, Janus kinase-binding protein 1).	Arginine	64-72	protein arginine methyltransferase 5	Homo sapiens	302-307
14519104-8	2004	All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue.	Arginine	140-148	cullin RTT101	Saccharomyces cerevisiae S288C	22-29
14570889-3	2004	Here we provide indirect but strong evidence for a malondialdehyde-derived cross-link requiring just one malondialdehyde molecule to link arginine and lysine, giving 2-ornithinyl-4-methyl(1epsilon-lysyl)1,3-imidazole following a 4-day incubation of albumin with 8 mm malondialdehyde.	Arginine	138-146	albumin	Homo sapiens	249-256
15844633-1	2004	The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC).	Arginine	4-12	tumor protein p53	Homo sapiens	28-31
15777019-8	2004	In addition to acute stimulatory actions of D-glucose and insulin on L-arginine transport and NO synthesis, gestational diabetes, intrauterine growth retardation and pre-eclampsia induce phenotypic changes in the fetal vasculature, resulting in alterations in the L-arginine/NO signalling pathway and regulation of [Ca2+]i.	Arginine	69-79	insulin	Homo sapiens	58-65
15777019-8	2004	In addition to acute stimulatory actions of D-glucose and insulin on L-arginine transport and NO synthesis, gestational diabetes, intrauterine growth retardation and pre-eclampsia induce phenotypic changes in the fetal vasculature, resulting in alterations in the L-arginine/NO signalling pathway and regulation of [Ca2+]i.	Arginine	264-274	insulin	Homo sapiens	58-65
14659757-5	2004	Here, we report the identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalytic function of PDI, ERp57, ERp72 and P5, specifically for reoxidation.	Arginine	50-58	protein disulfide isomerase family A member 3	Homo sapiens	247-252
14659757-5	2004	Here, we report the identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalytic function of PDI, ERp57, ERp72 and P5, specifically for reoxidation.	Arginine	50-58	protein disulfide isomerase family A member 4	Homo sapiens	254-259
14759083-2	2004	Because L-arginine, the NO synthase (NOS) precursor, augments NO bioactivity, we hypothesized that L-arginine would improve dysfunctional coronary sympathetic responses.	Arginine	8-18	nitric oxide synthase 2	Homo sapiens	24-35
14759083-2	2004	Because L-arginine, the NO synthase (NOS) precursor, augments NO bioactivity, we hypothesized that L-arginine would improve dysfunctional coronary sympathetic responses.	Arginine	99-109	nitric oxide synthase 2	Homo sapiens	24-35
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Arginine	4-7	tumor protein p53	Homo sapiens	66-69
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Arginine	8-11	tumor protein p53	Homo sapiens	66-69
14744727-1	2004	The Arg/Arg genotype versus Arg/Pro or Pro/Pro at codon 72 of the p53 gene has been implicated as a risk marker in cervical neoplasia.	Arginine	8-11	tumor protein p53	Homo sapiens	66-69
14613973-8	2004	Hence, although analogous proline--&gt;arginine mutations in FGFR1-3 act through a common structural mechanism to result in gain-of-function, differences in the primary sequence among FGFRs result in varying effects on ligand binding specificity.	Arginine	39-47	fibroblast growth factor receptor 1	Homo sapiens	61-66
17191776-6	2004	The free amino acids (R)- and (S)-H-beta2 hArg-OH and (S)-H-beta3 hArg-OH were tested for their ability to function as substrates for NO synthase (iNOS); the beta3-oligoarginine amides (5, 6, and 7 residues) were tested for antibacterial (against six pathogens) and hemolytic (against rat and human erythrocytes) activities.	Arginine	21-24	nitric oxide synthase 2	Rattus norvegicus	147-151
15258356-5	2004	The function of the NO, which is one of the more powerful endogenous vasodilators and whose synthesis is catalysed by nitric oxide synthase (NOS), can be determined by the ratio between blood concentrations of citrulline and arginine (the co-product and the precursor of the way of NO synthesis), which represents the level of activity of the enzyme.	Arginine	225-233	nitric oxide synthase 2	Homo sapiens	118-139
15658192-2	2004	Hb Zurich Albisrieden [alpha59(E8)Gly-->Arg (alpha2)] is not detected at the protein level and leads to alpha(+)-thalassemia (thal).	Arginine	40-43	glycoprotein hormone subunit alpha 2	Homo sapiens	45-51
14734460-8	2004	TP53 codon 72 Arg/Pro or Pro/Pro variants were associated with negative axillary lymph node status (OR, 0.7; 95% confidence interval, 0.49-0.94).	Arginine	14-17	tumor protein p53	Homo sapiens	0-4
14734461-5	2004	However, the age-related increase in the percentage of codon 72 arginine p53 was not correlated to the prognosis for gastric cancer patients.	Arginine	64-72	tumor protein p53	Homo sapiens	73-76
14734461-8	2004	CONCLUSIONS: These findings indicate that codon 72 arginine p53 may not be associated with a prolonged survival in patients with advanced gastric adenocarcinoma, but further study is needed to assess whether this polymorphism is associated with a late onset or slow progress of early gastric adenocarcinoma.	Arginine	51-59	tumor protein p53	Homo sapiens	60-63
14962794-8	2004	Arginine/glycine (RG)-rich domains in components of the SMN complex interact with Sm, like-Sm (LSm), fibrillarin, RNA helicase A (Gu), and coilin proteins, all of which are antigen targets in a variety of diseases.	Arginine	0-8	DExH-box helicase 9	Homo sapiens	114-128
15218265-2	2004	VMD2, together with VMD2L1, VMD2L2 and VMD2L3, belong to a closely related gene family characterized by several transmembrane (TM) spanning helical domains and an invariant arginine, phenylalanine and proline (RFP) tripeptide motif, thus termed VMD2 RFP-TM.	Arginine	173-181	bestrophin 1	Mus musculus	0-4
14711563-7	2004	The Bcl-2 concentration was similar in endometrial homogenates obtained throughout the menstrual cycle, but L-Arg decreased Bcl-2 only in endometrium from the proliferative phase.	Arginine	108-113	BCL2 apoptosis regulator	Homo sapiens	124-129
15658192-0	2004	A new highly unstable alpha chain variant causing alpha(+)-thalassemia: Hb Zurich Albisrieden [alpha59(E8)Gly-->Arg (alpha2)].	Arginine	112-115	glycoprotein hormone subunit alpha 2	Homo sapiens	117-123
15274481-5	2004	Administration of coconut protein and L-arginine in the ethanol fed rats caused decreased activity of HMG-CoA reductase in the liver and increased activity of lipoprotein lipase in the heart.	Arginine	38-48	lipoprotein lipase	Rattus norvegicus	159-177
15249740-12	2004	Mean GH peak was 27.7 and 14.6 times higher than baseline after arginine and 57.5 and 26.6 times higher than baseline after arginine plus GHRH in the control and experimental group, respectively.	Arginine	64-72	growth hormone 1	Homo sapiens	5-7
15249740-12	2004	Mean GH peak was 27.7 and 14.6 times higher than baseline after arginine and 57.5 and 26.6 times higher than baseline after arginine plus GHRH in the control and experimental group, respectively.	Arginine	124-132	growth hormone 1	Homo sapiens	5-7
14702176-4	2004	Enzymatically, iNOS facilitates intracellular nitric oxide (NO) synthesis from L-arginine.	Arginine	79-89	nitric oxide synthase 2, inducible	Mus musculus	15-19
15638127-11	2004	Higher arginine consumption was observed in BMMphi from both strains upon activation with IL-4 or IFNgamma which further increased, in this case, when the cells were infected with MHV3.	Arginine	7-15	interferon gamma	Mus musculus	98-106
14764039-6	2004	The women who had p53 (Arg/Arg), IRF-1 (T/T), and &lt;6 years of education showed a 14.7-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), IRF-1 ( approximately C), and &gt;15 years of education.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
15638127-12	2004	As a consequence of nitric oxide synthase synthesis and arginine consumption in IFNgamma activated BMMphi, we observed a higher synthesis of citrulline.	Arginine	56-64	interferon gamma	Mus musculus	80-88
14764039-6	2004	The women who had p53 (Arg/Arg), IRF-1 (T/T), and &lt;6 years of education showed a 14.7-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), IRF-1 ( approximately C), and &gt;15 years of education.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
14764039-7	2004	The women who had p53 (Arg/Arg), p21 (Ser/Ser), and &gt;3 children showed a 6.4-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), p21 ( approximately Arg), and no children.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
14764039-7	2004	The women who had p53 (Arg/Arg), p21 (Ser/Ser), and &gt;3 children showed a 6.4-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), p21 ( approximately Arg), and no children.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
14764039-7	2004	The women who had p53 (Arg/Arg), p21 (Ser/Ser), and &gt;3 children showed a 6.4-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), p21 ( approximately Arg), and no children.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
14764039-8	2004	The women who had p53 (Arg/Arg), IRF-1 (T/T), and first sexual intercourse before 22 years old showed a 5.5-fold increased risk of cervix cancer compared to the women who had p53 ( approximately Pro), IRF-1 ( approximately C), and first sexual intercourse after 26 years old.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
15325021-5	2004	Indeed, there is recent evidence that DDAH is inhibited by endothelial oxidative stress, a typical feature of endotheliopathy; there is also some reason to suspect that arginine transport may be less efficient in dysfunctional endothelium.	Arginine	169-177	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	38-42
15493055-7	2004	Respective C5a/C5a(des Arg) was 26.6 (range 4.9-74), 18.9 (9.5-42.6), and 30.9 (range: 10.7-62.3) ng/ml.	Arginine	23-26	complement C5a receptor 1	Homo sapiens	11-14
15493055-7	2004	Respective C5a/C5a(des Arg) was 26.6 (range 4.9-74), 18.9 (9.5-42.6), and 30.9 (range: 10.7-62.3) ng/ml.	Arginine	23-26	complement C5a receptor 1	Homo sapiens	15-18
15493055-9	2004	Mean C5a/C5a(des Arg) was 32.1 ng/ml (N = 30; range: 10.6-57.2) after 18 months of storage.	Arginine	17-20	complement C5a receptor 1	Homo sapiens	5-8
15711880-5	2004	The results suggest that the opposing effects of glutamate and arginine are not related to simply their charge structure, but must involve complex interactions between these molecules, Ca2+ and the regulatory and other myofibrillar proteins.	Arginine	63-71	carbonic anhydrase 2	Rattus norvegicus	185-188
15182209-1	2004	Nitric oxide (NO) is synthesized from L-arginine in the human respiratory tract by enzymes of the NO synthase (NOS) family.	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	98-109
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Arginine	54-62	interleukin 13	Homo sapiens	0-4
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Arginine	54-62	interleukin 13	Homo sapiens	91-95
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Arginine	54-62	interleukin 13	Homo sapiens	91-95
15381393-7	2004	Cells spreading on immobilized soluble fibrin were blocked by the exogenous addition of soluble fibrin and glycine-arginine-glycine-aspartic acid-serine-phenylalanine (GRGDSP)-synthetic peptide but not by the addition of fibrinogen or fibrin monomer.	Arginine	115-123	fibrinogen beta chain	Homo sapiens	221-231
14687932-0	2004	Somatic mutations to arginine residues affect the binding of human monoclonal antibodies to DNA, histones, SmD and Ro antigen.	Arginine	21-29	small nuclear ribonucleoprotein polypeptide N	Homo sapiens	107-110
15068667-6	2004	We observed that Lys-105 and Arg-109 are critical for IL13 binding to IL13Ralpha2, indeed.	Arginine	29-32	interleukin 13	Homo sapiens	54-58
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Arginine	169-177	transforming growth factor beta 1	Homo sapiens	53-85
15263792-7	2004	The proline form of p53 gene codon 72 was significantly higher than the arginine form, with an odds ratio of 2.606 (95% CI = 1.052-6.455).	Arginine	72-80	tumor protein p53	Homo sapiens	20-23
15263792-11	2004	The proline form of p53 gene codon 72 might be a more significant risk factor for the development of metastasis than the arginine form.	Arginine	121-129	tumor protein p53	Homo sapiens	20-23
14657028-3	2003	A mutation in pre-tRNA(Arg)(CCG) causes yeast cells to be cold-sensitive and to require the La protein Lhp1p for efficient growth.	Arginine	23-26	Lhp1p	Saccharomyces cerevisiae S288C	103-108
14657028-4	2003	When the mutant cells are grown at low temperature, or when Lhp1p is depleted, mature tRNA(Arg)(CCG) is not efficiently aminoacylated.	Arginine	91-94	Lhp1p	Saccharomyces cerevisiae S288C	60-65
14634213-7	2003	Further mutational analysis showed that arginines at positions 175 and 248 were essential for dicoumarol-induced p53 degradation.	Arginine	40-49	tumor protein p53	Homo sapiens	113-116
15651660-2	2004	The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72.	Arginine	87-95	tumor protein p53	Homo sapiens	51-54
15651660-2	2004	The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72.	Arginine	97-100	tumor protein p53	Homo sapiens	51-54
14527949-5	2003	The Arg-896-mediated ER retention of GluR5 is regulated by a mutation that mimics phosphorylation of Thr-898, but not by PDZ interactions.	Arginine	4-7	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	37-42
14662886-6	2003	Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met (HRYLPM) activated a broad spectrum of cellular signaling events, including an intracellular Ca(2+) concentration increase, phosphoinositide 3-kinase, extracellular signal-regulated kinase, and Akt activation, however, His-Glu-Tyr-Leu-Pro-Met (HEYLPM) activated only intracellular Ca(2+) concentration and Akt but did not increase Ca(2+).	Arginine	32-35	AKT serine/threonine kinase 1	Homo sapiens	246-249
14662886-6	2003	Among the HXYLPM analogues, His-Arg-Tyr-Leu-Pro-Met (HRYLPM) activated a broad spectrum of cellular signaling events, including an intracellular Ca(2+) concentration increase, phosphoinositide 3-kinase, extracellular signal-regulated kinase, and Akt activation, however, His-Glu-Tyr-Leu-Pro-Met (HEYLPM) activated only intracellular Ca(2+) concentration and Akt but did not increase Ca(2+).	Arginine	32-35	AKT serine/threonine kinase 1	Homo sapiens	358-361
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Arginine	122-132	nitric oxide synthase 2	Homo sapiens	28-32
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Arginine	122-132	myeloperoxidase	Homo sapiens	47-50
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Arginine	122-132	nitric oxide synthase 2	Homo sapiens	106-110
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Arginine	169-177	transforming growth factor beta 1	Homo sapiens	87-96
14596813-1	2003	The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production.	Arginine	169-177	transforming growth factor beta 1	Homo sapiens	217-226
14760971-7	2003	iNOS enzyme activity was quantified using an arginine/citrulline assay.	Arginine	45-53	nitric oxide synthase 2	Homo sapiens	0-4
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	23-31	nitric oxide synthase 2	Homo sapiens	55-86
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	23-31	nitric oxide synthase 2	Homo sapiens	88-92
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	244-252	nitric oxide synthase 2	Homo sapiens	88-92
14646164-8	2003	Therefore, ALCK-modified GAPDH is deduced to be digested at the peptide bond Trp(195)-Arg(196).	Arginine	86-89	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	25-30
15147044-12	2003	Combined study on the distribution of GSTM1, GSTT1 and p53 genotypes revealed that null GSTM1 genotype was associated with the Arg allele of p53 codon 72 in 58 lung carcinoma cells and null GSTT1 genotype was associated with the Pro/Pro homozygote in 104 tumor cell lines examined.	Arginine	127-130	tumor protein p53	Homo sapiens	55-58
15147044-12	2003	Combined study on the distribution of GSTM1, GSTT1 and p53 genotypes revealed that null GSTM1 genotype was associated with the Arg allele of p53 codon 72 in 58 lung carcinoma cells and null GSTT1 genotype was associated with the Pro/Pro homozygote in 104 tumor cell lines examined.	Arginine	127-130	glutathione S-transferase mu 1	Homo sapiens	88-93
15147044-12	2003	Combined study on the distribution of GSTM1, GSTT1 and p53 genotypes revealed that null GSTM1 genotype was associated with the Arg allele of p53 codon 72 in 58 lung carcinoma cells and null GSTT1 genotype was associated with the Pro/Pro homozygote in 104 tumor cell lines examined.	Arginine	127-130	tumor protein p53	Homo sapiens	141-144
14674686-3	2003	Chemical modification of ETF with arginine-specific reagents resulted in the loss, to varying degrees, of activity with medium chain acyl-coenzyme A dehydrogenase (MCAD).	Arginine	34-42	acyl-CoA dehydrogenase medium chain	Homo sapiens	120-162
14675203-0	2003	p53 codon 72 Arg homozygotes are associated with an increased risk of cutaneous melanoma.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
14675203-6	2003	The frequency of the p53 Arg allele was 78.2% in cases and 73.2% in controls (p=0.045), and the genotype frequencies of p53 Arg/Arg, Arg/Pro, and Pro/Pro were 62.6%, 31.1%, and 6.3%, respectively, in the cases, and 53.9%, 38.6%, and 7.5%, respectively, in the controls (p=0.096).	Arginine	25-28	tumor protein p53	Homo sapiens	21-24
14675203-7	2003	Logistic regression analysis revealed that the p53 Arg/Arg genotype was associated with a significantly increased risk of melanoma (adjusted odds ratio (OR)=1.43; 95% confidence interval (CI)=1.02-2.02) compared with other genotypes, and this association was more evident in subgroups of older subjects (OR=2.32; 95% CI=1.39-388), and subjects with Fitzpatrick"s skin type III or IV (OR=1.69; 95% CI=1.11-2.59).	Arginine	51-54	tumor protein p53	Homo sapiens	47-50
14675203-7	2003	Logistic regression analysis revealed that the p53 Arg/Arg genotype was associated with a significantly increased risk of melanoma (adjusted odds ratio (OR)=1.43; 95% confidence interval (CI)=1.02-2.02) compared with other genotypes, and this association was more evident in subgroups of older subjects (OR=2.32; 95% CI=1.39-388), and subjects with Fitzpatrick"s skin type III or IV (OR=1.69; 95% CI=1.11-2.59).	Arginine	55-58	tumor protein p53	Homo sapiens	47-50
14675203-8	2003	In conclusion, this study found some evidence that in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of CM as compared to genotypes Arg/Pro or Pro/Pro.	Arginine	76-79	tumor protein p53	Homo sapiens	72-75
14675203-8	2003	In conclusion, this study found some evidence that in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of CM as compared to genotypes Arg/Pro or Pro/Pro.	Arginine	80-83	tumor protein p53	Homo sapiens	72-75
14675203-8	2003	In conclusion, this study found some evidence that in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of CM as compared to genotypes Arg/Pro or Pro/Pro.	Arginine	80-83	tumor protein p53	Homo sapiens	72-75
14675208-8	2003	These data suggest a coordinated consumption of L-arginine by the NOS and arginase enzymatic pathways at the wound site as a prerequisite for a balanced NO (via iNOS) and polyamine (via arginases) synthesis that drives a normal skin repair.	Arginine	48-58	nitric oxide synthase 2, inducible	Mus musculus	161-165
14534352-3	2003	The two major enzymes PRMT1 (type I) and PRMT5 (type II) preferentially methylate arginines located in RG-rich clusters.	Arginine	82-91	protein arginine methyltransferase 5	Homo sapiens	41-46
14674686-3	2003	Chemical modification of ETF with arginine-specific reagents resulted in the loss, to varying degrees, of activity with medium chain acyl-coenzyme A dehydrogenase (MCAD).	Arginine	34-42	acyl-CoA dehydrogenase medium chain	Homo sapiens	164-168
14674686-5	2003	For activity with MCAD, maximum inactivation of ETF was accomplished by 2,3-butanedione (4% residual activity after 120 min) and it was shown that modification of one arginine residue was responsible for the inactivation.	Arginine	167-175	acyl-CoA dehydrogenase medium chain	Homo sapiens	18-22
14674686-8	2003	Full protection of ETF from arginine modification by 2,3-butanedione was achieved using substrate-protected DMGDH, MCAD and SDH respectively.	Arginine	28-36	acyl-CoA dehydrogenase medium chain	Homo sapiens	115-119
14674686-10	2003	These results lead us to conclude that this single arginine residue is essential in the binding of the ETF to MCAD, but only contributes partially to the binding of ETF to SDH and DMGDH and thus, the determinants of the dehydrogenase binding sites overlap but are not identical.	Arginine	51-59	acyl-CoA dehydrogenase medium chain	Homo sapiens	110-114
14618086-2	2003	This ORF encodes a 10-kDa protein (p10) carrying two distinct domains: a basic, arginine-rich domain and a zinc-finger domain.	Arginine	80-88	S100 calcium binding protein A10	Homo sapiens	35-38
15127941-6	2003	In these chimeric ligands, the agonist DPhe-Arg-Trp amino acids were replaced by the AGRP Arg-Phe-Phe residues, and resulted in agonist activity at the mouse melanocortin receptors (mMC1R and mMC3-5Rs), supporting the hypothesis that the AGRP antagonist ligand Arg-Phe-Phe residues mimic the agonist Phe-Arg-Trp amino acids.	Arginine	90-93	agouti related neuropeptide	Mus musculus	85-89
12970351-0	2003	Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating.	Arginine	0-8	5-hydroxytryptamine receptor 3A	Homo sapiens	50-56
14750503-5	2003	The inhibitory activity against thrombin or botrocetin is mainly linked to Arg-Arg-Pro-Phe or Trp-Ile-Arg-Arg-Pro, respectively, among nine amino acids.	Arginine	75-78	coagulation factor II, thrombin	Homo sapiens	32-40
14750503-5	2003	The inhibitory activity against thrombin or botrocetin is mainly linked to Arg-Arg-Pro-Phe or Trp-Ile-Arg-Arg-Pro, respectively, among nine amino acids.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	32-40
14750503-5	2003	The inhibitory activity against thrombin or botrocetin is mainly linked to Arg-Arg-Pro-Phe or Trp-Ile-Arg-Arg-Pro, respectively, among nine amino acids.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	32-40
14750503-5	2003	The inhibitory activity against thrombin or botrocetin is mainly linked to Arg-Arg-Pro-Phe or Trp-Ile-Arg-Arg-Pro, respectively, among nine amino acids.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	32-40
12970351-4	2003	Arginine 222 (Arg-222), located at the distal end of the extracellular N-terminal domain immediately preceding the first transmembrane domain (TM1), is conserved in all 5-HT3A receptors and alpha7-nicotinic acetylcholine receptors that have been cloned.	Arginine	0-8	5-hydroxytryptamine receptor 3A	Homo sapiens	169-175
12970351-4	2003	Arginine 222 (Arg-222), located at the distal end of the extracellular N-terminal domain immediately preceding the first transmembrane domain (TM1), is conserved in all 5-HT3A receptors and alpha7-nicotinic acetylcholine receptors that have been cloned.	Arginine	0-3	5-hydroxytryptamine receptor 3A	Homo sapiens	169-175
12970351-5	2003	To elucidate the possible role of Arg-222 in the function of 5-HT3A receptors, we mutated the arginine residue to alanine (Ala) and expressed both the wild-type and the mutant receptor in human embryonic kidney 293 cells.	Arginine	34-37	5-hydroxytryptamine receptor 3A	Homo sapiens	61-67
12970351-10	2003	The results suggest that the pre-TM1 amino acid residue Arg-222 may be involved in the transduction mechanism linking agonist binding to channel gating in 5-HT3A receptors.	Arginine	56-59	5-hydroxytryptamine receptor 3A	Homo sapiens	155-161
14599552-7	2003	Our results also showed that the decrease of NO production by iNOS could be achieved by depleting arginine from the medium even under the conditions that would up-regulate iNOS expression.	Arginine	98-106	nitric oxide synthase 2	Homo sapiens	62-66
14609340-6	2003	The catalytic activity of 4-amino-H(4)B-bound FLiNOS and HDiNOS resembles that of pterin-free iNOS: the hydroxylation of arginine is very unfavorable (&lt;2% that of H(4)B-bound iNOS), and NHA is oxidized to a mixture of amino acid products (citrulline and cyanoornithine) and NO(-) rather than (*)NO.	Arginine	121-129	nitric oxide synthase 2	Homo sapiens	48-52
14609340-6	2003	The catalytic activity of 4-amino-H(4)B-bound FLiNOS and HDiNOS resembles that of pterin-free iNOS: the hydroxylation of arginine is very unfavorable (&lt;2% that of H(4)B-bound iNOS), and NHA is oxidized to a mixture of amino acid products (citrulline and cyanoornithine) and NO(-) rather than (*)NO.	Arginine	121-129	nitric oxide synthase 2	Homo sapiens	59-63
14563493-2	2003	We have used phage display selection from randomly mutated C5a des-Arg(74) libraries to isolate variant proteins that can activate C5a receptors with similar potency to C5a.	Arginine	67-70	complement C5a receptor 1	Homo sapiens	131-134
12925531-2	2003	Several modes of inhibitor binding in the COX active site have been described including ion pairing of carboxylic acid containing inhibitors with Arg-120 of COX-1 and COX-2 and insertion of arylsulfonamides and sulfones into the COX-2 side pocket.	Arginine	146-149	cytochrome c oxidase I, mitochondrial	Mus musculus	157-162
12952971-0	2003	Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production.	Arginine	98-108	nitric oxide synthase 3	Homo sapiens	36-69
14597228-7	2003	A role for arginine methylation has been observed in some RG-containing SMN-interacting proteins.	Arginine	11-19	survival of motor neuron 1, telomeric	Rattus norvegicus	72-75
14563493-2	2003	We have used phage display selection from randomly mutated C5a des-Arg(74) libraries to isolate variant proteins that can activate C5a receptors with similar potency to C5a.	Arginine	67-70	complement C5a receptor 1	Homo sapiens	131-134
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	19-22	complement C5a receptor 1	Homo sapiens	23-27
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	19-22	complement C5a receptor 1	Homo sapiens	23-26
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	19-22	complement C5a receptor 1	Homo sapiens	59-62
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	67-70	complement C5a receptor 1	Homo sapiens	23-27
14624632-1	2003	The purpose of this study was to evaluate the human MC1 receptor-mediated melanoma targeting properties of two metal cyclized alpha-MSH peptide analogues, (188)Re-(Arg(11))CCMSH and (188)Re-CCMSH.	Arginine	164-167	proopiomelanocortin	Homo sapiens	126-135
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	67-70	complement C5a receptor 1	Homo sapiens	23-26
14563493-4	2003	The mutant Asp(282)Arg-C5aR is preferentially activated by C5a des-Arg(74), probably due to repulsion between Arg(74) of C5a and the substituent Arg(282).	Arginine	67-70	complement C5a receptor 1	Homo sapiens	59-62
14563493-7	2003	Arg(175) is a potential counterion for the C-terminal carboxylate of C5a.	Arginine	0-3	complement C5a receptor 1	Homo sapiens	69-72
14563493-8	2003	C5aR mutated to either Ala or Asp at this position lost nearly all responsiveness to both C5a and C5a des-Arg(74), suggesting that mutation of Arg(175) caused a non-specific loss of receptor conformation and a loss of signalling capacity.	Arginine	106-109	complement C5a receptor 1	Homo sapiens	0-4
14563493-8	2003	C5aR mutated to either Ala or Asp at this position lost nearly all responsiveness to both C5a and C5a des-Arg(74), suggesting that mutation of Arg(175) caused a non-specific loss of receptor conformation and a loss of signalling capacity.	Arginine	106-109	complement C5a receptor 1	Homo sapiens	0-3
14617022-3	2003	The LBR gene (LBR) was also sequenced from a single English man with Pelger-Huet anomaly and a heterozygous C-->G mutation was found in codon 569 of exon 14, predicted to cause a proline-->arginine.	Arginine	189-197	lamin B receptor	Homo sapiens	14-17
12922151-1	2003	Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications.	Arginine	23-31	fibronectin 1	Homo sapiens	141-152
14617022-3	2003	The LBR gene (LBR) was also sequenced from a single English man with Pelger-Huet anomaly and a heterozygous C-->G mutation was found in codon 569 of exon 14, predicted to cause a proline-->arginine.	Arginine	189-197	lamin B receptor	Homo sapiens	4-7
14568929-1	2003	Inducible NO synthase (iNOS) and its generation of NO from L-arginine are subject to transcriptional as well as posttranscriptional control by cytokines.	Arginine	59-69	nitric oxide synthase 2, inducible	Mus musculus	0-21
14616884-8	2003	Mean serum GH secretory peak after GHRH-Arg stimulation test was reduced in five subjects (mean 9.3 +/- 3.6 microg/l, P &lt; 0.006 vs. Controls, mean 67.0 +/- 44.0 microg/l, cut-off, 16.0 microg/l) and normal in one subject (38.7 microg/l).	Arginine	40-43	growth hormone releasing hormone	Homo sapiens	35-39
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Arginine	206-209	bone gamma-carboxyglutamate protein	Rattus norvegicus	142-153
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Arginine	235-238	bone gamma-carboxyglutamate protein	Rattus norvegicus	142-153
14622283-3	2003	In the presence of additives, including arginine and guanidine (100 microM), more than 30% of 0.2 mg x mL(-1) lysozyme in sodium phosphate buffer (pH 6.5) formed insoluble aggregates by heat treatment (98 degrees C for 30 min).	Arginine	40-48	lysozyme	Homo sapiens	110-118
14622283-5	2003	The residual activity of lysozyme after this heat treatment was very low (&lt; 5%), even in the presence of 100 microM arginine and guanidine, while it was maintained at approximately 50% in the presence of 100 microM spermine and spermidine.	Arginine	119-127	lysozyme	Homo sapiens	25-33
14556720-1	2003	Nitric oxide (NOz.rad;) is a diatomic mediator liberated on oxidation of L-arginine by the nitric oxide synthase (NOS) family of enzymes.	Arginine	73-83	nitric oxide synthase 2	Homo sapiens	91-112
14668357-2	2003	Recessive mutations in ras2 and cyr1, as well as elevated dosage of PDE2, allowed cox2::arg8m-G66S to support Arg prototrophy.	Arginine	110-113	3',5'-cyclic-nucleotide phosphodiesterase PDE2	Saccharomyces cerevisiae S288C	68-72
14668357-2	2003	Recessive mutations in ras2 and cyr1, as well as elevated dosage of PDE2, allowed cox2::arg8m-G66S to support Arg prototrophy.	Arginine	110-113	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	82-86
14568929-1	2003	Inducible NO synthase (iNOS) and its generation of NO from L-arginine are subject to transcriptional as well as posttranscriptional control by cytokines.	Arginine	59-69	nitric oxide synthase 2, inducible	Mus musculus	23-27
14568929-2	2003	In this study, we describe a novel, translational mechanism of iNOS regulation by arginine availability.	Arginine	82-90	nitric oxide synthase 2, inducible	Mus musculus	63-67
14568929-3	2003	Using mouse inflammatory peritoneal macrophages stimulated with IFN-gamma plus LPS, we demonstrate that the suppression of iNOS protein, which is observed after a 16-h (but not after a 6-h) pretreatment with IL-13, despite an unaltered iNOS mRNA level, results from arginine depletion by arginase.	Arginine	266-274	nitric oxide synthase 2, inducible	Mus musculus	123-127
14568929-4	2003	The addition of arginase inhibitors (in the pretreatment phase) or of arginine (in the stimulation phase) completely blocked the down-regulation of iNOS protein by IL-13.	Arginine	70-78	nitric oxide synthase 2, inducible	Mus musculus	148-152
14568929-4	2003	The addition of arginase inhibitors (in the pretreatment phase) or of arginine (in the stimulation phase) completely blocked the down-regulation of iNOS protein by IL-13.	Arginine	70-78	interleukin 13	Mus musculus	164-169
14568929-6	2003	A striking suppression of iNOS protein (but not of iNOS mRNA) was also seen, when IL-13 was replaced by purified arginase or when macrophages were stimulated with IFN-gamma/LPS in arginine-free medium.	Arginine	180-188	nitric oxide synthase 2, inducible	Mus musculus	26-30
14568929-6	2003	A striking suppression of iNOS protein (but not of iNOS mRNA) was also seen, when IL-13 was replaced by purified arginase or when macrophages were stimulated with IFN-gamma/LPS in arginine-free medium.	Arginine	180-188	interferon gamma	Mus musculus	163-172
14568929-8	2003	From these results, we conclude that arginine not only functions as a substrate for iNOS, but is also critical for maintaining normal levels of iNOS protein in cytokine-stimulated macrophages.	Arginine	37-45	nitric oxide synthase 2, inducible	Mus musculus	84-88
14568929-8	2003	From these results, we conclude that arginine not only functions as a substrate for iNOS, but is also critical for maintaining normal levels of iNOS protein in cytokine-stimulated macrophages.	Arginine	37-45	nitric oxide synthase 2, inducible	Mus musculus	144-148
14732339-9	2003	Similar results were observed in iNOS(-/-) mice, in which these mechanisms were potentiated and reverted by nitro and L-arginine treatments, respectively.	Arginine	118-128	nitric oxide synthase 2, inducible	Mus musculus	33-37
14608199-6	2003	CONCLUSIONS: These results demonstrate that the frequency of TGF-beta1 gene 509 (C--&gt;T), codon 25 (Arg--&gt;Pro), and codon 10 (Leu--&gt;Pro) polymorphisms and alleles do not play a role as a genetic risk factor in the development and clinical progress of ITP.	Arginine	102-105	transforming growth factor beta 1	Homo sapiens	61-70
14572769-2	2003	NO is synthesized from L-arginine by three different isozymes of nitric oxide synthase (nNOS, iNOS and eNOS).	Arginine	23-33	nitric oxide synthase 2	Rattus norvegicus	94-98
14511639-1	2003	The fragile X mental retardation protein (FMRP) contains three RNA binding domains, two of which the KH2 domain and the C-terminal arginine-glycine-rich (RG-rich) region participate in RNA binding.	Arginine	131-139	fragile X messenger ribonucleoprotein 1	Homo sapiens	4-40
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	151-159	coagulation factor II, thrombin	Homo sapiens	20-28
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	151-159	coagulation factor II, thrombin	Homo sapiens	109-117
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	180-183	coagulation factor II, thrombin	Homo sapiens	20-28
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	180-183	coagulation factor II, thrombin	Homo sapiens	109-117
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	188-191	coagulation factor II, thrombin	Homo sapiens	20-28
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	188-191	coagulation factor II, thrombin	Homo sapiens	109-117
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	188-191	coagulation factor II, thrombin	Homo sapiens	20-28
15143519-5	2003	It is supposed that thrombin binding with organic ligands occurs owing anionic site of beta-domain of active thrombin centre with the major aminoacids arginine and lysine (Lys 68, Arg 78, Arg 77, Arg 66 etc.).	Arginine	188-191	coagulation factor II, thrombin	Homo sapiens	109-117
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Arginine	161-164	Rho GTPase activating protein 26	Homo sapiens	301-305
12912999-4	2003	The high affinity of P1 for DNA is achieved by the coordinated binding of three anchoring domains, which together in bull P1 contain 19 Arg residues.	Arginine	136-139	protamine 1	Homo sapiens	21-23
12912999-4	2003	The high affinity of P1 for DNA is achieved by the coordinated binding of three anchoring domains, which together in bull P1 contain 19 Arg residues.	Arginine	136-139	protamine 1	Homo sapiens	122-124
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Arginine	63-66	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-1	2003	Exosite 1 of thrombin consists of a cluster of basic residues (Arg-35, Lys-36, Arg-67, Lys-70, Arg-73, Arg-75, and Arg-77 in chymotrypsinogen numbering) that play key roles in the function of thrombin.	Arginine	79-82	coagulation factor II, thrombin	Homo sapiens	13-21
14523228-2	2003	Structural data suggest that the side chain of Arg-35 projects toward the active site pocket of thrombin, but all other residues are poised to interact with thrombomodulin (TM).	Arginine	47-50	coagulation factor II, thrombin	Homo sapiens	96-104
14523228-8	2003	These results suggest that Arg-35 is responsible for the Ca2+ dependence of PC activation by the thrombin-TM complex and that a function for TM in the activation complex is the allosteric alleviation of the inhibitory interaction of Arg-35 with the substrate.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	97-105
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Arginine	34-42	SH3 domain containing kinase binding protein 1	Homo sapiens	61-66
14512444-2	2003	For a better understanding of the underlying pathophysiological mechanisms, we aimed to characterize the intracellular arginine sources of eNOS.	Arginine	119-127	nitric oxide synthase 3	Homo sapiens	139-143
14512444-3	2003	Our previous studies in human endothelial EA.hy926 cells suggested the existence of two arginine pools: pool I can be depleted by extracellular lysine, whereas pool II is not freely exchangeable with the extracellular space, but accessible to eNOS.	Arginine	88-96	nitric oxide synthase 3	Homo sapiens	243-247
14581358-0	2003	Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients.	Arginine	30-38	tumor protein p53	Homo sapiens	17-20
14581358-0	2003	Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients.	Arginine	117-125	tumor protein p53	Homo sapiens	17-20
14581358-5	2003	RESULTS: We found that the retention of the p53 codon 72 arginine allele in the tumor tissue of proline/arginine heterozygous breast cancer patients is associated with statistically significant reduced disease-free and overall survivals.	Arginine	57-65	tumor protein p53	Homo sapiens	44-47
14581358-5	2003	RESULTS: We found that the retention of the p53 codon 72 arginine allele in the tumor tissue of proline/arginine heterozygous breast cancer patients is associated with statistically significant reduced disease-free and overall survivals.	Arginine	104-112	tumor protein p53	Homo sapiens	44-47
14581358-6	2003	CONCLUSIONS: Our findings suggest that the genotyping for p53 codon 72 locus in both the tumor tissue and in the lymph node of breast cancer patients could contribute to identify a subset of arginine/proline heterozygous patients who have a reduced survival that is associated with the specific retention of the arginine allele in the tumor tissue.	Arginine	191-199	tumor protein p53	Homo sapiens	58-61
14581358-6	2003	CONCLUSIONS: Our findings suggest that the genotyping for p53 codon 72 locus in both the tumor tissue and in the lymph node of breast cancer patients could contribute to identify a subset of arginine/proline heterozygous patients who have a reduced survival that is associated with the specific retention of the arginine allele in the tumor tissue.	Arginine	312-320	tumor protein p53	Homo sapiens	58-61
14511639-1	2003	The fragile X mental retardation protein (FMRP) contains three RNA binding domains, two of which the KH2 domain and the C-terminal arginine-glycine-rich (RG-rich) region participate in RNA binding.	Arginine	131-139	fragile X messenger ribonucleoprotein 1	Homo sapiens	42-46
12816759-11	2003	Our results indicate that OXA inhibition of the MMC involves the OX1R and that activation of a L-arginine/NO pathway possibly originating from OX1R/nNOS-containing neurons in the myenteric plexus may mediate this effect.	Arginine	95-105	hypocretin receptor 1	Rattus norvegicus	143-147
14507173-2	2003	An 11-residue beta-peptide (1), an all-beta homologue of the Arg-rich region Tat 47-57, binds TAR RNA with K(d) = 29 +/- 4 nM.	Arginine	61-64	RNA binding motif protein 8A	Homo sapiens	94-97
12805063-1	2003	We synthesized BbetaArg14His fibrinogen with histidine substituted for arginine at the Bbeta thrombin-cleavage site.	Arginine	71-79	coagulation factor II, thrombin	Homo sapiens	93-101
12844488-8	2003	However, the p53 mutation frequency increased with the increased number of the combined genotypes among XPD 312WT (Asp/Asp), XPD 751VT (Lys/Gln or Gln/Gln) or XRCC1 399VT (Arg/Gln or Gln/Gln) (P = 0.01, trend test).	Arginine	172-175	tumor protein p53	Homo sapiens	13-16
12855711-6	2003	Modeling of a cyclic 6-mer peptide containing the consensus sequence and superposition of its three-dimensional structure onto the VWF A3-domain demonstrated that the Ser and Arg in the peptide matched the Ser1020 and Arg1016 in the A3-domain.	Arginine	175-178	von Willebrand factor	Homo sapiens	131-134
14692513-0	2003	Binding of the human "electron transferring flavoprotein" (ETF) to the medium chain acyl-CoA dehydrogenase (MCAD) involves an arginine and histidine residue.	Arginine	126-134	acyl-CoA dehydrogenase medium chain	Homo sapiens	71-106
14692513-0	2003	Binding of the human "electron transferring flavoprotein" (ETF) to the medium chain acyl-CoA dehydrogenase (MCAD) involves an arginine and histidine residue.	Arginine	126-134	acyl-CoA dehydrogenase medium chain	Homo sapiens	108-112
14692513-3	2003	Here we show that binding of human ETF, to MCAD, was inhibited by 2,3-butanedione and diethylpyrocarbonate (DEPC) and reversed by incubation with free arginine and hydroxylamine respectively.	Arginine	151-159	acyl-CoA dehydrogenase medium chain	Homo sapiens	43-47
14692513-4	2003	Spectral analyses of native ETF vs modified ETF suggested that flavin binding was not affected and that the loss of ETF activity with MCAD involved modification of one ETF arginine residue and one ETF histidine residue respectively.	Arginine	172-180	acyl-CoA dehydrogenase medium chain	Homo sapiens	134-138
14692513-5	2003	MCAD and octanoyl-CoA protected ETF against inactivation by both 2,3-butanedione and DEPC indicating that the arginine and histidine residues are present in or around the MCAD binding site.	Arginine	110-118	acyl-CoA dehydrogenase medium chain	Homo sapiens	0-4
14692513-5	2003	MCAD and octanoyl-CoA protected ETF against inactivation by both 2,3-butanedione and DEPC indicating that the arginine and histidine residues are present in or around the MCAD binding site.	Arginine	110-118	acyl-CoA dehydrogenase medium chain	Homo sapiens	171-175
14692513-7	2003	These results lead us to conclude that this single arginine residue is essential for the binding of ETF to MCAD, but that the single histidine residue, although involved, is not.	Arginine	51-59	acyl-CoA dehydrogenase medium chain	Homo sapiens	107-111
14577584-0	2003	Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India.	Arginine	33-36	tumor protein p53	Homo sapiens	20-23
14577584-3	2003	This degradation is controlled by a common polymorphism of the p53 gene encoding either a proline or an arginine at its codon 72 in exon 4.	Arginine	104-112	tumor protein p53	Homo sapiens	63-66
14577584-4	2003	Recently, it has been demonstrated that the presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation as well as to cervical cancer than those with proline homozygotes or proline/arginine heterozygotes.	Arginine	67-75	tumor protein p53	Homo sapiens	96-99
14577584-4	2003	Recently, it has been demonstrated that the presence of homozygous arginine at codon 72 renders p53 about seven times more susceptible to E6-mediated proteolytic degradation as well as to cervical cancer than those with proline homozygotes or proline/arginine heterozygotes.	Arginine	251-259	tumor protein p53	Homo sapiens	96-99
14577584-12	2003	Thus the interaction between HPV oncoproteins and the p53 gene polymorphism specifically, homozygous arginine at codon 72 appears to play no role in the development of either cervical or oral cancer and also it can not serve as a biomarker for early identification of cervical, oral or breast cancer.	Arginine	101-109	tumor protein p53	Homo sapiens	54-57
14569381-1	2003	Erectile dysfunction (ED) management in the following 3-5 years will be dominated by substances targeting the L-arginine-NO-guanylate cyclase-cGMP-PDE-5 pathway, resulting in an intracellular elevation of the cGMP concentrations.	Arginine	110-120	phosphodiesterase 5A	Homo sapiens	147-152
12860985-2	2003	In contrast, alpha1-proteinase inhibitor (alpha1PI) Pittsburgh (P1 Met --&gt; Arg natural variant) inhibits thrombin 17 times faster than pentasaccharide heparin-activated antithrombin.	Arginine	78-81	coagulation factor II, thrombin	Homo sapiens	108-116
12925564-10	2003	Incubation in medium containing l-arginine reversed the endothelial cell dysfunction associated with 11HSD2 inactivation.	Arginine	32-42	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	101-107
14516401-3	2003	NO is synthesized from l-arginine by nitric oxide synthase, and in the kidney iNOS is expressed spontaneously.	Arginine	23-33	nitric oxide synthase 2	Rattus norvegicus	78-82
14562395-15	2003	IPC or L-arginine attenuated P-selectin expression remarkably (P&lt;0.01).	Arginine	7-17	selectin P	Rattus norvegicus	29-39
12845643-7	2003	Similarly, L-NAME reduced and additional treatment with excess L-arginine or sodium nitroprusside (SNP, NO donor) stimulated phosphorylation of extracellular signal-regulated kinases (ERK(1/2)), demonstrating a role for endogenous and exogenous NO in ERK(1/2) activation.	Arginine	63-73	mitogen-activated protein kinase 3	Homo sapiens	184-191
14572312-1	2003	BACKGROUND: Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-gamma (rIFN-gamma), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).	Arginine	12-20	interferon gamma	Homo sapiens	120-136
12919725-1	2003	The p53 gene has a polymorphism at codon 72 that presents the arginine or proline genotype, although this polymorphism has been associated with genetically determined susceptibility to lung cancers, the literature has not been consistent with this association.	Arginine	62-70	tumor protein p53	Homo sapiens	4-7
12950161-5	2003	The present work demonstrates that mouse cells deficient in both c-Abl and Arg exhibit increased catalase stability.	Arginine	75-78	catalase	Mus musculus	97-105
12845643-7	2003	Similarly, L-NAME reduced and additional treatment with excess L-arginine or sodium nitroprusside (SNP, NO donor) stimulated phosphorylation of extracellular signal-regulated kinases (ERK(1/2)), demonstrating a role for endogenous and exogenous NO in ERK(1/2) activation.	Arginine	63-73	mitogen-activated protein kinase 3	Homo sapiens	251-258
12950161-7	2003	Significantly, ubiquitination of catalase is dependent on c-Abl- and Arg-mediated phosphorylation of catalase on both Y231 and Y386.	Arginine	69-72	catalase	Homo sapiens	33-41
12950161-7	2003	Significantly, ubiquitination of catalase is dependent on c-Abl- and Arg-mediated phosphorylation of catalase on both Y231 and Y386.	Arginine	69-72	catalase	Homo sapiens	101-109
12845643-9	2003	Finally, both ODQ and UO126 blocked the capacity of L-arginine to restore ERK(1/2) phosphorylation in L-NAME-treated cells, demonstrating that GC and MEK are both required for endogenous NO-mediated MAPK activation.	Arginine	52-62	mitogen-activated protein kinase 3	Homo sapiens	74-81
12845643-9	2003	Finally, both ODQ and UO126 blocked the capacity of L-arginine to restore ERK(1/2) phosphorylation in L-NAME-treated cells, demonstrating that GC and MEK are both required for endogenous NO-mediated MAPK activation.	Arginine	52-62	mitogen-activated protein kinase kinase 7	Homo sapiens	150-153
12815063-9	2003	These two residues are unique to FHFs, and mutations of the corresponding residues of FGF1 to Arg and Val diminish the capacity of FGF1 to activate FGFRs, suggesting that these two FHF residues contribute to the inability of FHFs to activate FGFRs.	Arginine	94-97	fibroblast growth factor 1	Homo sapiens	86-90
12815038-8	2003	Data base queries using the peptide (Arg-Glu-Thr-Tyr-X) generated from the most preferred amino acid at each subsite identify albumin as the sole, soluble, human extracellular protein containing this sequence.	Arginine	37-40	albumin	Homo sapiens	126-133
12970748-6	2003	The changes in ER-alpha expression and activity were abrogated in response to estradiol by an arginine to cysteine mutation in the pleckstrin homology (PH) domain of Akt (R25C), suggesting the involvement of this amino acid in the interaction between Akt and ER-alpha.	Arginine	94-102	estrogen receptor 1	Homo sapiens	15-23
12970748-6	2003	The changes in ER-alpha expression and activity were abrogated in response to estradiol by an arginine to cysteine mutation in the pleckstrin homology (PH) domain of Akt (R25C), suggesting the involvement of this amino acid in the interaction between Akt and ER-alpha.	Arginine	94-102	AKT serine/threonine kinase 1	Homo sapiens	166-169
12970748-6	2003	The changes in ER-alpha expression and activity were abrogated in response to estradiol by an arginine to cysteine mutation in the pleckstrin homology (PH) domain of Akt (R25C), suggesting the involvement of this amino acid in the interaction between Akt and ER-alpha.	Arginine	94-102	AKT serine/threonine kinase 1	Homo sapiens	251-254
12970748-6	2003	The changes in ER-alpha expression and activity were abrogated in response to estradiol by an arginine to cysteine mutation in the pleckstrin homology (PH) domain of Akt (R25C), suggesting the involvement of this amino acid in the interaction between Akt and ER-alpha.	Arginine	94-102	estrogen receptor 1	Homo sapiens	259-267
12815063-9	2003	These two residues are unique to FHFs, and mutations of the corresponding residues of FGF1 to Arg and Val diminish the capacity of FGF1 to activate FGFRs, suggesting that these two FHF residues contribute to the inability of FHFs to activate FGFRs.	Arginine	94-97	fibroblast growth factor 1	Homo sapiens	131-135
14499862-4	2003	RESULTS: A novel missense mutation, G to A at position 154 in the KCNE1 gene was identified in a Chinese Long QT syndrome family, which leads to an amino acid substitution of arginine (R) for glycine (G) at position 52 (G52R-KCNE1).	Arginine	175-183	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	66-71
12748062-8	2003	Exposure to Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (substance P) but not to calcitonin gene-related peptide increased pepsinogen release.	Arginine	12-15	tachykinin precursor 1	Homo sapiens	61-72
12944028-8	2003	L-arginine enhanced these effects (P &lt;.001) in the subjects without AII inhibition, but not in those receiving AII inhibitors.	Arginine	0-10	angiotensinogen	Homo sapiens	71-74
13130468-2	2003	Citrulline is a nonstandard amino acid that can be incorporated into proteins only by posttranslational modification of arginine by peptidylarginine deiminase (PAD) enzymes.	Arginine	120-128	paddle	Mus musculus	132-158
13130468-2	2003	Citrulline is a nonstandard amino acid that can be incorporated into proteins only by posttranslational modification of arginine by peptidylarginine deiminase (PAD) enzymes.	Arginine	120-128	paddle	Mus musculus	160-163
12962694-2	2003	Insulin normally increases blood flow by a mechanism which involves generation of nitric oxide (NO) via the arginine-NO pathway.	Arginine	108-116	insulin	Homo sapiens	0-7
14499862-4	2003	RESULTS: A novel missense mutation, G to A at position 154 in the KCNE1 gene was identified in a Chinese Long QT syndrome family, which leads to an amino acid substitution of arginine (R) for glycine (G) at position 52 (G52R-KCNE1).	Arginine	175-183	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	225-230
12940876-2	2003	Nitric oxide (NO) is formed enzymatically from l-arginine in the presence of nitric oxide synthase (NOS).	Arginine	47-57	nitric oxide synthase 2	Homo sapiens	77-98
14656046-2	2003	NO is synthesized from L-arginine by NO synthase occurring in three isoforms of (neuronal, nNOS; endothelial, eNOS; inducible, iNOS).	Arginine	23-33	nitric oxide synthase 2, inducible	Mus musculus	127-131
15376949-6	2003	As an example, CGU, CGG, and AGA, which are synonymous codons of Arg, are preferential to form the alpha unit in all alpha proteins, while CGA is an alpha unit breaker and the other two synonymous codons, CGC and AGG, are indifferent to form or break the alpha unit.	Arginine	65-68	chromogranin A	Homo sapiens	139-142
12919321-8	2003	It has been shown that these agents modify Arg, Lys and Trp residues of the apoB protein of LDL, with the extent of modification induced by the two aldehydes being more rapid than with glucose.	Arginine	43-46	apolipoprotein B	Homo sapiens	76-80
12871028-3	2003	NO, a highly reactive radical, is produced from L-arginine and oxygen by the enzyme NO synthase (NOS).	Arginine	48-58	nitric oxide synthase 2	Homo sapiens	84-95
12911535-0	2003	Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis.	Arginine	25-35	endothelin 1	Rattus norvegicus	74-86
13678705-0	2003	Inhibition of nitric oxide synthase (NOS) conversion of L-arginine to nitric oxide (NO) decreases low density mononuclear cell (LD MNC) trans-endothelial migration and cytokine output.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	14-35
12970297-8	2003	ARG increased (P &lt; 0.05) both insulin and glucose levels.	Arginine	0-3	insulin	Homo sapiens	33-40
12970297-10	2003	Ghrelin blunted (P &lt; 0.05) the insulin response to ARG and enhanced (P &lt; 0.05) the ARG-induced increase in glucose levels.	Arginine	54-57	insulin	Homo sapiens	34-41
12970318-7	2003	Molecular analysis revealed that foci of malignancy and adjacent areas of hyperplasia and some areas of normal thyroid harbored activating mutations of Arg(201) in the GNAS1 gene.	Arginine	152-155	GNAS complex locus	Homo sapiens	168-173
12911535-14	2003	Exaggerated urinary ET-1 of PHN was reduced by 23% and 40% after l-arginine and lisinopril, respectively, and by 62% with the combination.	Arginine	65-75	endothelin 1	Rattus norvegicus	20-24
12911535-16	2003	CONCLUSION: Combining l-arginine with ACE inhibitors would represent a novel strategy for patients with severe nephropathy not completely responsive to ACE inhibition.	Arginine	22-32	angiotensin I converting enzyme	Homo sapiens	152-155
12794066-3	2003	Using a substrate-based screening assay for factor XIII activity complemented by kinetic analysis of activation peptide cleavage, we show by using thrombin mutants of surface-exposed residues that Arg-178, Arg-180, Asp-183, Glu-229, Arg-233, and Trp-50 of thrombin are necessary for direct activation of factor XIII.	Arginine	197-200	coagulation factor II, thrombin	Homo sapiens	147-155
12941912-4	2003	TAXREB803 is an SR-related protein composed of 2,752 amino acids including numerous arginine/serine (RS) motifs.	Arginine	84-92	PNN interacting serine and arginine rich protein	Homo sapiens	16-34
12967769-3	2003	Although several mechanisms are proposed to explain the reduction of cNOS activity, reduced substrate availability, caused by a combination of increased arginase activity and decreased cellular uptake of L-arginine, appears to play a key role.	Arginine	204-214	nitric oxide synthase 3	Homo sapiens	69-73
12967769-5	2003	Thus, at low concentrations of L-arginine iNOS produces both NO and superoxide anions, which results in the increased synthesis of the highly reactive, detrimental oxidant peroxynitrite.	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	42-46
12810712-7	2003	The results show that while the interactions of the sulfuryl moiety and the phenyl ring with the YopH active site contribute to pNCS binding affinity, additional interactions of the hydroxyl and nitro groups in pNCS with Asp-356, Gln-357, Arg-404, and Gln-446 are responsible for the increased potency and selectivity.	Arginine	239-242	YopH	Yersinia pestis	97-101
12810712-8	2003	In particular, we note that residues Arg-404, Glu-290, Asp-356, and a bound water (WAT185) participate in a unique H-bonding network with the hydroxyl group ortho to the sulfuryl moiety, which may be exploited to design more potent and specific YopH inhibitors.	Arginine	37-40	YopH	Yersinia pestis	245-249
12972575-6	2003	Hrp1p relocalization requires both the CRM1/XPO1 exportin and the FPS1 glycerol transporter genes but is independent of ongoing RNA transcription and protein arginine methylation.	Arginine	158-166	Hrp1p	Saccharomyces cerevisiae S288C	0-5
12963341-4	2003	The smaller form represents the V5-His tagged pro-CCK after cleavage at a single arginine residue at CCK-58.	Arginine	81-89	Drosulfakinin	Drosophila melanogaster	50-53
12956884-1	2003	The novel allele DRB1*0445 differs from DRB1*04051 by a single nucleotide substitution at codon 23 (CGG--&gt;CCG), resulting in an amino-acid change from arginine to proline.	Arginine	154-162	major histocompatibility complex, class II, DR beta 1	Homo sapiens	17-21
12956884-1	2003	The novel allele DRB1*0445 differs from DRB1*04051 by a single nucleotide substitution at codon 23 (CGG--&gt;CCG), resulting in an amino-acid change from arginine to proline.	Arginine	154-162	major histocompatibility complex, class II, DR beta 1	Homo sapiens	40-44
12794066-3	2003	Using a substrate-based screening assay for factor XIII activity complemented by kinetic analysis of activation peptide cleavage, we show by using thrombin mutants of surface-exposed residues that Arg-178, Arg-180, Asp-183, Glu-229, Arg-233, and Trp-50 of thrombin are necessary for direct activation of factor XIII.	Arginine	197-200	coagulation factor II, thrombin	Homo sapiens	256-264
12899627-9	2003	Biophysical properties of the C5L2, including slow ligand on and off rates, absence of internalization, and relatively high affinity for the C5a des Arg metabolite, suggest that this receptor may serve to modulate C5a biological functions in vivo.	Arginine	149-152	hemolytic complement	Mus musculus	141-144
12960118-10	2003	Melting point analysis of the hybridization probes determined that all 21 patient samples had arginine at codon 482 of BCRP mRNA, the wild-type form.	Arginine	94-102	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	119-123
12899627-9	2003	Biophysical properties of the C5L2, including slow ligand on and off rates, absence of internalization, and relatively high affinity for the C5a des Arg metabolite, suggest that this receptor may serve to modulate C5a biological functions in vivo.	Arginine	149-152	hemolytic complement	Mus musculus	214-217
12904077-1	2003	It has been shown by extensive studies that alpha-MSH bioactivity is critically dependent on the core or central tetrapeptide sequence, His-Phe-Arg-Trp, however with poor selectivity for the human MC3R-MC5R.	Arginine	144-147	proopiomelanocortin	Homo sapiens	44-53
12777400-4	2003	The results show that H2O2 induced binding of c-Abl and Arg to catalase.	Arginine	56-59	catalase	Homo sapiens	63-71
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Arginine	64-67	mitogen-activated protein kinase 1	Homo sapiens	179-183
12777400-5	2003	The SH3 domains of c-Abl and Arg bound directly to catalase at a P293FNP site.	Arginine	29-32	catalase	Homo sapiens	51-59
12777400-0	2003	Catalase activity is regulated by c-Abl and Arg in the oxidative stress response.	Arginine	44-47	catalase	Homo sapiens	0-8
12777400-6	2003	c-Abl and Arg phosphorylated catalase at Tyr231 and Tyr386 in vitro and in the response of cells to H2O2.	Arginine	10-13	catalase	Homo sapiens	29-37
12777400-3	2003	This work demonstrates that catalase, a major effector of the cellular defense against H2O2, interacts with c-Abl and Arg.	Arginine	118-121	catalase	Homo sapiens	28-36
12777400-9	2003	These findings indicate that c-Abl and Arg regulate catalase and that this signaling pathway is of importance to apoptosis in the oxidative stress response.	Arginine	39-42	catalase	Homo sapiens	52-60
12716655-3	2003	Glucocorticoids can inhibit iNOS activity in cultured cells by blocking arginine transport and inhibiting tetrahydrobiopterin biosynthesis.	Arginine	72-80	nitric oxide synthase 2	Rattus norvegicus	28-32
12885237-8	2003	The polar ethanolamide moiety of AEA, like the carboxylate of arachidonate, interacts with Arg-120 at the bottom of the COX-2 active site.	Arginine	91-94	prostaglandin-endoperoxide synthase 2	Homo sapiens	120-125
12885237-12	2003	Importantly, the COX-2 side pocket and Arg-513 in particular are critical determinants of the ability of COX-2 to efficiently generate prostaglandin H(2) ethanolamide.	Arginine	39-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-110
12922936-0	2003	Extracellular L-arginine is required for optimal NO synthesis by eNOS and iNOS in the rat mesenteric artery wall.	Arginine	14-24	nitric oxide synthase 2	Rattus norvegicus	74-78
12741957-0	2003	A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.	Arginine	99-107	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	75-80
12741957-2	2003	At least three variant forms of ABCG2 have been hitherto documented on the basis of their amino acid moieties (i.e., arginine, glycine and threonine) at position 482.	Arginine	117-125	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	32-37
12741957-4	2003	Exogenous expression of the Arg(482), Gly(482), and Thr(482) variant forms of ABCG2 conferred HEK-293 cell resistance toward mitoxantrone 15-, 47- and 54-fold, respectively, as compared with mock-transfected HEK-293 cells.	Arginine	28-31	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	78-83
12741957-6	2003	[Arg(482)]ABCG2 transports [(3)H]methotrexate in an ATP-dependent manner; however, no transport activity was observed with the other variants (Gly(482) and Thr(482)).	Arginine	1-4	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	10-15
12741957-7	2003	Transport of methotrexate by [Arg(482)]ABCG2 was significantly inhibited by mitoxantrone, doxorubicin and rhodamine 123, but not by S -octylglutathione.	Arginine	30-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	39-44
12741957-11	2003	It is concluded that Arg(482) is a critical amino acid moiety in the substrate specificity and transport of ABCG2 for certain drugs, such as methotrexate.	Arginine	21-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-113
12922936-9	2003	Impairment of eNOS by iNOS was also prevented by L-arginine 100 micro M administered simultaneously with carbachol, but not by L-arginine administered during incubation with lipopolysaccharide.	Arginine	49-59	nitric oxide synthase 2	Rattus norvegicus	22-26
12922936-11	2003	These data provide functional evidence that supplementing L-arginine from the extracellular medium optimises the formation of NO from eNOS and suggests that the impairment of eNOS by iNOS is caused by excess formation of superoxide by NO synthase, which can be prevented by L-arginine.	Arginine	58-68	nitric oxide synthase 2	Rattus norvegicus	183-187
12922936-11	2003	These data provide functional evidence that supplementing L-arginine from the extracellular medium optimises the formation of NO from eNOS and suggests that the impairment of eNOS by iNOS is caused by excess formation of superoxide by NO synthase, which can be prevented by L-arginine.	Arginine	274-284	nitric oxide synthase 2	Rattus norvegicus	183-187
12922936-12	2003	These results provide an explanation for the observations that extracellular L-arginine can enhance endothelium function only when the endothelium is impaired or when iNOS has been induced.	Arginine	77-87	nitric oxide synthase 2	Rattus norvegicus	167-171
12883322-9	2003	Addition of BH4 or SEP substantially induced iNOS enzyme activity, which was quantified as the formation of [3H]L-citrulline from [3H]L-arginine.	Arginine	134-144	nitric oxide synthase 2	Homo sapiens	45-49
12919895-0	2003	[L-arginine decreases P-selectin expression in traumatic shock].	Arginine	1-11	selectin P	Rattus norvegicus	22-32
12919895-8	2003	In L-Arg treatment group, P-selectin levels were significantly lowered than those of shock group.	Arginine	3-8	selectin P	Rattus norvegicus	26-36
12919895-10	2003	L-Arg may decrease the expression of P-selectin very likely through promoting endothelial NO synthesis.	Arginine	0-5	selectin P	Rattus norvegicus	37-47
12756249-8	2003	Further adhesion experiments demonstrated that binding of trophoblast cells to fibronectin was completely inhibited by a peptide of the Arg-Gly-Asp (RGD) sequence, which binds to integrins alpha5beta1, alphaVbeta1, alphaVbeta3, and alphaVbeta5, whereas non-binding peptide containing Arg-Gly-Glu (RGE) had minimal effects.	Arginine	136-139	fibronectin 1	Homo sapiens	79-90
12756249-8	2003	Further adhesion experiments demonstrated that binding of trophoblast cells to fibronectin was completely inhibited by a peptide of the Arg-Gly-Asp (RGD) sequence, which binds to integrins alpha5beta1, alphaVbeta1, alphaVbeta3, and alphaVbeta5, whereas non-binding peptide containing Arg-Gly-Glu (RGE) had minimal effects.	Arginine	284-287	fibronectin 1	Homo sapiens	79-90
12864804-7	2003	The relationship between the increment in serum GH following GHRH + GHRP-6 and arginine + GHRH test was positive, i.e. r = 0.749, P = 0.001.Thus, there was high concordance between both tests.	Arginine	79-87	growth hormone releasing hormone	Homo sapiens	61-65
12864804-7	2003	The relationship between the increment in serum GH following GHRH + GHRP-6 and arginine + GHRH test was positive, i.e. r = 0.749, P = 0.001.Thus, there was high concordance between both tests.	Arginine	79-87	growth hormone releasing hormone	Homo sapiens	90-94
12746441-3	2003	In this study, by systematic deletion and site-directed mutagenesis we identified Arg-214/215 in the alpha-helix 2 region of the coiled-coil domain of Stat3 as a novel sequence element essential for its nuclear translocation, stimulated by epidermal growth factor as well as by interleukin-6.	Arginine	82-85	signal transducer and activator of transcription 3	Homo sapiens	151-156
12746441-3	2003	In this study, by systematic deletion and site-directed mutagenesis we identified Arg-214/215 in the alpha-helix 2 region of the coiled-coil domain of Stat3 as a novel sequence element essential for its nuclear translocation, stimulated by epidermal growth factor as well as by interleukin-6.	Arginine	82-85	interleukin 6	Homo sapiens	278-291
12746441-4	2003	Furthermore, we identified Arg-414/417 in the DNA binding domain as also required for the nuclear localization of Stat3.	Arginine	27-30	signal transducer and activator of transcription 3	Homo sapiens	114-119
12746441-7	2003	The mutant of Arg-214/215 or Arg-414/417 was shown to be tyrosyl-phosphorylated normally but failed to enter the nucleus in response to epidermal growth factor or interleukin-6.	Arginine	14-17	interleukin 6	Homo sapiens	163-176
12746441-9	2003	Mutations on Arg-414/417, but not Arg-214/215, destroy the DNA binding activity of Stat3.	Arginine	13-16	signal transducer and activator of transcription 3	Homo sapiens	83-88
12874219-5	2003	In these studies we mutated Arg(578) and Lys(579) of P2X(7), and the expression profile, channel activity, and pore formation of the mutant were characterized in transfected human embryonic kidney 293 cells.	Arginine	28-31	purinergic receptor P2X 7	Homo sapiens	53-59
12874210-6	2003	The results show that macrophages stimulated with IL-4 + IL-13 up-regulate ASE I and cationic amino acid transporter 2B, causing a rapid reduction of extracellular levels of L-arginine and inducing decreased expression of CD3zeta and diminished proliferation in normal T lymphocytes.	Arginine	174-184	interleukin 4	Homo sapiens	50-54
12874210-6	2003	The results show that macrophages stimulated with IL-4 + IL-13 up-regulate ASE I and cationic amino acid transporter 2B, causing a rapid reduction of extracellular levels of L-arginine and inducing decreased expression of CD3zeta and diminished proliferation in normal T lymphocytes.	Arginine	174-184	interleukin 13	Homo sapiens	57-62
12874219-3	2003	This domain is homologous to the LPS binding region of the LPS binding protein, and we demonstrated that two basic residues (Arg(578), Lys(579)) within this motif are essential for LPS binding to P2X(7) in vitro.	Arginine	125-128	purinergic receptor P2X 7	Homo sapiens	196-202
12890816-0	2003	Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of metal catalysed oxidation of proline and arginine residues of low density lipoprotein apolipoprotein B-100 in human atherosclerotic lesions.	Arginine	110-118	apolipoprotein B	Homo sapiens	155-175
12890816-1	2003	gamma-Glutamyl-semialdehyde (gammaGSA) is a major product of the metal catalysed oxidation of apolipoprotein B-100 (apoB-100) proline and arginine residues.	Arginine	138-146	apolipoprotein B	Homo sapiens	94-114
12874227-8	2003	A conservative replacement of Arg for Lys at P5 completely abrogated binding to CD94/NKG2.	Arginine	30-33	killer cell lectin-like receptor, subfamily D, member 1	Mus musculus	80-84
12846746-0	2003	NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis.	Arginine	36-46	Thy-1 cell surface antigen	Rattus norvegicus	91-95
12969557-3	2003	Here we describe a method for inducing iNOS in the porcine basilar artery followed by the detection of iNOS protein by immunocytochemical means and the characterisation of functional responses to U46619 and L-arginine.	Arginine	207-217	nitric oxide synthase 2	Homo sapiens	39-43
12969557-7	2003	The vasodilator response to L-arginine was prevented with the incubation with and in the presence of the inhibitor of inducible NOS, 1400W (10 microM) in addition to LPS.	Arginine	28-38	nitric oxide synthase 2	Homo sapiens	118-131
12969557-9	2003	The assessment of contractile function and responses to L-arginine using single concentrations is a rapid and effective method for establishing whether functional iNOS is present in porcine cerebral arteries.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	163-167
12952393-4	2003	Considerable amounts of by-products were formed in the case of Xaa = Asp(OtBu), Arg(Pbf), Asn(Mtt), Cys(Acm) and unprotected Thr.	Arginine	80-83	PTTG1 interacting protein	Homo sapiens	84-87
12794180-14	2003	The inhibition of VIP or NO synthase prevented L-arginine- and VIP-induced intestinal fluid secretion through a neural mechanism.	Arginine	47-57	vasoactive intestinal peptide	Rattus norvegicus	18-21
12846746-1	2003	UNLABELLED: NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis.	Arginine	48-58	Thy-1 cell surface antigen	Rattus norvegicus	103-107
12846746-3	2003	Supplementing dietary L-arginine intake has been shown to limit transforming growth factor (TGF)-beta 1 overproduction and matrix accumulation in rats with induced anti-thy1 glomerulonephritis (GN).	Arginine	22-32	transforming growth factor, beta 1	Rattus norvegicus	64-103
12846746-3	2003	Supplementing dietary L-arginine intake has been shown to limit transforming growth factor (TGF)-beta 1 overproduction and matrix accumulation in rats with induced anti-thy1 glomerulonephritis (GN).	Arginine	22-32	Thy-1 cell surface antigen	Rattus norvegicus	169-173
12846746-9	2003	Compared to untreated nephritic rats, administration of both L-arginine and molsidomine reduced glomerular TGF-beta 1 overexpression significantly and to a similar degree in both protocols, while the beneficial effect of L-arginine was abolished by concomitant NO synthesis inhibition.	Arginine	61-71	transforming growth factor, beta 1	Rattus norvegicus	107-117
12846746-11	2003	CONCLUSION: The present study shows that L-arginine"s antifibrotic action in normotensive anti-thy1 GN is mainly mediated by endogenous production of NO.	Arginine	41-51	Thy-1 cell surface antigen	Rattus norvegicus	95-99
12890027-5	2003	The increase of Int protein synthesis also takes place when the rare arginine codons AGA and AGG at positions 3 and 4 are changed to common arginine CGT or lysine AAA codons but not to rare isoleucine ATA codons.	Arginine	69-77	hypothetical protein	Escherichia coli	16-19
12869638-8	2003	Substitution of arginine for all eight lysines of p12 almost abolished its ubiquitination.	Arginine	16-24	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	50-53
12900683-2	2003	The amino acid, arginine, is known to stimulate insulin release and enhance glucose-stimulated insulin release.	Arginine	16-24	insulin	Homo sapiens	48-55
12900683-2	2003	The amino acid, arginine, is known to stimulate insulin release and enhance glucose-stimulated insulin release.	Arginine	16-24	insulin	Homo sapiens	95-102
12890027-7	2003	Therefore, cell growth and Int synthesis inhibition may be due to ribosome stalling and premature release of peptidyl-tRNAArg4 from the ribosome at the rare arginine codons of the first tandem, which leads to cell starvation for the specific tRNA.	Arginine	157-165	hypothetical protein	Escherichia coli	27-30
12893432-2	2003	To address on the genetic risk factor for NPC, we investigated association between the p53 codon 72 polymorphism (Pro/Arg) and NPC susceptibility in the Thai.	Arginine	118-121	tumor protein p53	Homo sapiens	87-90
14658402-1	2003	We report the clinical and neuropathological features of a Japanese family with familial amyotrophic lateral sclerosis (FALS), whose members have an amino acid substitution of histidine by arginine in Cu/Zn superoxide dismutase.	Arginine	189-197	superoxide dismutase 1	Homo sapiens	201-227
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	177-180	coagulation factor II, thrombin	Homo sapiens	37-45
12895295-6	2003	In addition, L-arginine prevents the rise of MDA, as well as a reduction of GSH-Px and catalase activities in kidney tissues homogenates.	Arginine	13-23	catalase	Rattus norvegicus	87-95
12867984-7	2003	Replacement of three arginine residues unique to the HA-stretch of the 5-HT3A subunit by their 5-HT3B subunit counterparts increased single-channel conductance 28-fold.	Arginine	21-29	5-hydroxytryptamine receptor 3A	Homo sapiens	71-77
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor II, thrombin	Homo sapiens	37-45
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor II, thrombin	Homo sapiens	37-45
12689334-2	2003	Full FVIII activation requires cleavage at Arg(372), a process involving the alpha-thrombin exosite-II; referred to as heparin-binding site (HBS).	Arginine	43-46	coagulation factor II, thrombin	Homo sapiens	83-91
12734181-2	2003	The binding of CaM is mediated in part by the electrostatic interaction between residues Arg-464 and Lys-467 of SK2 and Glu-84 and Glu-87 of CaM.	Arginine	89-92	calmodulin 3	Homo sapiens	15-18
12847215-0	2003	Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.	Arginine	32-40	major histocompatibility complex, class II, DR beta 1	Homo sapiens	143-151
12644443-7	2003	TGF-beta1 and matrix proteins increased when mesangial cells were cultured with excess l-arginine (2.08 mM) alone.	Arginine	87-97	transforming growth factor, beta 1	Rattus norvegicus	0-9
12850397-8	2003	The Arg(25) polymorphism in the TGF-beta(1) gene is associated with higher BP.	Arginine	4-7	transforming growth factor, beta 1	Rattus norvegicus	32-43
12849920-2	2003	Recent studies have suggested that glutamine(Q isoform)/arginine(R isoform) polymorphism at position 192 of PON(1) gene is associated with macrovascular disease of type 2 diabetes mellitus (T2DM).	Arginine	56-64	paraoxonase 1	Homo sapiens	108-114
12824780-3	2003	METHODS: Twenty-five pubertal HIV-infected children were assessed for GH response (GH-AUC(0-120 min)) to arginine + GHRH testing, insulin-like growth factor-1 (IGF-1), IGF binding protein 3 (IGFBP-3), insulin, glucose, cholesterol, triglycerides, free fatty acids and nitric oxide levels.	Arginine	105-113	growth hormone 1	Homo sapiens	70-72
12824780-3	2003	METHODS: Twenty-five pubertal HIV-infected children were assessed for GH response (GH-AUC(0-120 min)) to arginine + GHRH testing, insulin-like growth factor-1 (IGF-1), IGF binding protein 3 (IGFBP-3), insulin, glucose, cholesterol, triglycerides, free fatty acids and nitric oxide levels.	Arginine	105-113	growth hormone 1	Homo sapiens	83-85
12829643-5	2003	Arginine-stimulated second-phase insulin response was used as a measure of beta-cell capacity.	Arginine	0-8	insulin	Homo sapiens	33-40
12821336-1	2003	INTRODUCTION: We aimed to verify not only whether homozygous Arg at codon 72 of the p53 apoptotic domain is a possible risk factor for cervical human papillomavirus (HPV)-related cancer, but whether degraded p53 may have an effect on a G2 checkpoint of the cell cycle.	Arginine	61-64	tumor protein p53	Homo sapiens	84-87
12818446-1	2003	OBJECTIVE: [corrected] An experimental study has indicated that individuals homozygous for the Arg-encoding allele of p53 gene may have an increased susceptibility to HPV-related cervical cancer but many epidemiological studies have failed to repeat this result.	Arginine	95-98	tumor protein p53	Homo sapiens	118-121
12818446-3	2003	The aim of the present work was to investigate whether the p53 arginine allele confers a risk factor for cervical carcinogenesis.	Arginine	63-71	tumor protein p53	Homo sapiens	59-62
12821336-1	2003	INTRODUCTION: We aimed to verify not only whether homozygous Arg at codon 72 of the p53 apoptotic domain is a possible risk factor for cervical human papillomavirus (HPV)-related cancer, but whether degraded p53 may have an effect on a G2 checkpoint of the cell cycle.	Arginine	61-64	tumor protein p53	Homo sapiens	208-211
12843189-4	2003	Insulin sensitivity, assessed by hyperinsulinemic-euglycemic clamp, was significantly reduced in carriers of Arg(972) IRS-1 (P &lt; 0.03).	Arginine	109-112	insulin	Homo sapiens	0-7
12824702-6	2003	When a comparison of the distribution of the p53 codon 72 polymorphism was made between patients with a first-degree family history and all control subjects, the adjusted odds ratios (ORs) for prostate cancer associated with the Arg/Arg, Arg/Pro and Pro/Pro genotypes were 1.00, 0.99 [95% confidence interval (CI) 0.53-1.88] and 2.80 (95% CI 1.04-7.53), respectively.	Arginine	229-232	tumor protein p53	Homo sapiens	45-48
12824702-6	2003	When a comparison of the distribution of the p53 codon 72 polymorphism was made between patients with a first-degree family history and all control subjects, the adjusted odds ratios (ORs) for prostate cancer associated with the Arg/Arg, Arg/Pro and Pro/Pro genotypes were 1.00, 0.99 [95% confidence interval (CI) 0.53-1.88] and 2.80 (95% CI 1.04-7.53), respectively.	Arginine	233-236	tumor protein p53	Homo sapiens	45-48
12824702-6	2003	When a comparison of the distribution of the p53 codon 72 polymorphism was made between patients with a first-degree family history and all control subjects, the adjusted odds ratios (ORs) for prostate cancer associated with the Arg/Arg, Arg/Pro and Pro/Pro genotypes were 1.00, 0.99 [95% confidence interval (CI) 0.53-1.88] and 2.80 (95% CI 1.04-7.53), respectively.	Arginine	233-236	tumor protein p53	Homo sapiens	45-48
12843189-6	2003	These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities.	Arginine	31-34	insulin	Homo sapiens	185-192
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Arginine	125-135	protein kinase C alpha	Homo sapiens	48-51
12892231-4	2003	Mutational screening of the hSNF5/INI1 gene by heteroduplex and direct sequence analysis detected a missense mutation at codon 53 (CGA --> TGA, arginine --> stop) in both tumors, as well as in normal tissue of the kidney.	Arginine	144-152	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	28-33
12892231-4	2003	Mutational screening of the hSNF5/INI1 gene by heteroduplex and direct sequence analysis detected a missense mutation at codon 53 (CGA --> TGA, arginine --> stop) in both tumors, as well as in normal tissue of the kidney.	Arginine	144-152	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	34-38
12787412-10	2003	l-Arg had a beneficial effect on GFR and RPF, decreased O2- production, diminished up-regulation of soluble guanylate cyclase, and prevented up-regulation of iNOS.	Arginine	0-5	nitric oxide synthase 2	Rattus norvegicus	158-162
12796783-3	2003	Abl1 (previously known as Abl) and the Abl1-related gene product Abl2 (previously known as Arg) define a family of tyrosine kinases that regulate actin structure and presynaptic axon guidance.	Arginine	91-94	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	Mus musculus	65-69
12818188-7	2003	Moreover, human hepatic cathepsin L cleaved 77IL-8 between Arg(5) and Ser(6), which is the same cleavage site as the putative converting enzyme, resulting in 72IL-8 formation.	Arginine	59-62	cathepsin L	Homo sapiens	24-35
12818188-7	2003	Moreover, human hepatic cathepsin L cleaved 77IL-8 between Arg(5) and Ser(6), which is the same cleavage site as the putative converting enzyme, resulting in 72IL-8 formation.	Arginine	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
12824821-8	2003	The ACTH response to acute intragastric alcohol injection was significantly (p &lt; 0.01) decreased by the arginine derivative N omega-nitro-L-arginine-methylester, which nonspecifically blocks NOS activity, as well as by the specific neuronal NOS antagonist 7-nitroindazole.	Arginine	107-115	proopiomelanocortin	Homo sapiens	4-8
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Arginine	190-200	protein kinase C alpha	Homo sapiens	48-51
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Arginine	32-42	protein kinase C alpha	Homo sapiens	91-99
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Arginine	32-42	protein kinase C alpha	Homo sapiens	91-94
12562561-4	2003	The inhibitory effect of PMA on l-arginine transport was accompanied by a translocation of PKCalpha (a classical PKC isoform) from the cytosol to the membrane fraction, whereas the activating effect of PMA on l-arginine transport was accompanied by full depletion of the expression of PKCalpha in PAEC.	Arginine	32-42	protein kinase C alpha	Homo sapiens	285-293
12562561-5	2003	A selective activator of Ca(2+)-dependent classical isoforms of PKC, thymeleatoxin (Thy; 100 nM; 1-h and 18-h treatments), induced the same changes in l-arginine uptake and PKCalpha translocation and depletion as PMA.	Arginine	151-161	protein kinase C alpha	Homo sapiens	64-67
12562561-6	2003	The effects of PMA and Thy on l-arginine transport in PAEC were attenuated by a selective inhibitor of classical PKC isoforms Go 6976 (1 micro M).	Arginine	30-40	protein kinase C alpha	Homo sapiens	113-116
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Arginine	131-139	coagulation factor II, thrombin	Homo sapiens	19-27
12736155-0	2003	Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans.	Arginine	23-33	insulin	Homo sapiens	70-77
12736155-2	2003	There is, however, some evidence to assume that the l-arginine membrane transport capacity is dependent on insulin plasma levels.	Arginine	52-62	insulin	Homo sapiens	107-114
12736155-3	2003	We hypothesized that vasodilator effects of l-arginine may be dependent on insulin plasma levels.	Arginine	44-54	insulin	Homo sapiens	75-82
12736155-9	2003	Coinfusion of l-arginine with insulin caused a dose-dependent leftward shift of the vasodilator effect of l-arginine.	Arginine	14-24	insulin	Homo sapiens	30-37
12736155-9	2003	Coinfusion of l-arginine with insulin caused a dose-dependent leftward shift of the vasodilator effect of l-arginine.	Arginine	106-116	insulin	Homo sapiens	30-37
12736155-10	2003	This stereospecific renal and ocular vasodilator potency of l-arginine is enhanced by insulin, which may result from facilitated l-arginine membrane transport, enhanced intracellular NO formation, or increased NO bioavailability.	Arginine	60-70	insulin	Homo sapiens	86-93
12736155-10	2003	This stereospecific renal and ocular vasodilator potency of l-arginine is enhanced by insulin, which may result from facilitated l-arginine membrane transport, enhanced intracellular NO formation, or increased NO bioavailability.	Arginine	129-139	insulin	Homo sapiens	86-93
12766013-0	2003	The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG(183)HIS (R183H) GH-I gene mutation.	Arginine	149-152	growth hormone 1	Homo sapiens	10-24
12766013-0	2003	The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG(183)HIS (R183H) GH-I gene mutation.	Arginine	149-152	growth hormone 1	Homo sapiens	26-28
12766119-2	2003	Endothelium-dependent vasodilation of the renal vasculature cannot be easily assessed, but infusion of L-arginine, the substrate of endothelial nitric oxide synthase, leads to an increase in renal plasma flow (RPF) in humans.	Arginine	103-113	nitric oxide synthase 3	Homo sapiens	132-165
12796380-0	2003	Age-associated increase of codon 72 Arginine p53 frequency in gastric cardia and non-cardia adenocarcinoma.	Arginine	36-44	tumor protein p53	Homo sapiens	45-48
12796380-6	2003	A significant stepwise increased frequency of codon 72 Arg p53 with age was observed in patients with gastric cancer, but not in noncancer patients (P = 0.01).	Arginine	55-58	tumor protein p53	Homo sapiens	59-62
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Arginine	102-105	tumor protein p53	Homo sapiens	98-101
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Arginine	102-105	tumor protein p53	Homo sapiens	214-217
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Arginine	102-105	tumor protein p53	Homo sapiens	214-217
12796380-8	2003	After adjustment for age and gender, a logistic regression analysis suggested that the risk for a p53 Arg homozygous patient to develop cardia cancer is 3.1 95% confidence interval, 1.4-7.3) times greater than for p53 Pro homozygous and p53 Arg/Pro heterozygous patients.	Arginine	241-244	tumor protein p53	Homo sapiens	98-101
12796380-10	2003	CONCLUSIONS: These findings indicate that codon 72 Arg p53 may be associated with a prolonged survival for patients who have had gastric adenocarcinoma, especially non-cardia adenocarcinoma.	Arginine	51-54	tumor protein p53	Homo sapiens	55-58
14527200-2	2003	Of the three genes in the paraoxonase gene family, PON1 shows a polymorphism, Gln 192 --&gt; Arg, governed by two common alleles named *Q and *R. These determine two different isoforms associated, respectively, with lower and higher activity towards paraoxon, a toxic metabolic product of the insecticide parathion.	Arginine	93-96	paraoxonase 1	Homo sapiens	26-37
14527200-2	2003	Of the three genes in the paraoxonase gene family, PON1 shows a polymorphism, Gln 192 --&gt; Arg, governed by two common alleles named *Q and *R. These determine two different isoforms associated, respectively, with lower and higher activity towards paraoxon, a toxic metabolic product of the insecticide parathion.	Arginine	93-96	paraoxonase 1	Homo sapiens	51-55
12813015-1	2003	Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.	Arginine	221-229	interleukin 13	Mus musculus	183-188
12756290-5	2003	Upon stimulation of NO production by bradykinin, however, recycling is co-stimulated to the extent that more than 80% of the citrulline produced is recycled to arginine.	Arginine	160-168	kininogen 1	Homo sapiens	37-47
12756290-1	2003	The enzyme endothelial nitric oxide synthase (eNOS) catalyzes the conversion of arginine, oxygen and NADPH to NO and citrulline.	Arginine	80-88	nitric oxide synthase 3	Homo sapiens	11-44
12756290-1	2003	The enzyme endothelial nitric oxide synthase (eNOS) catalyzes the conversion of arginine, oxygen and NADPH to NO and citrulline.	Arginine	80-88	nitric oxide synthase 3	Homo sapiens	46-50
12679372-2	2003	Here we show that several different substitutions of a positively charged amino acid residue, arginine R334, in the putative outer mouth of the CFTR pore, greatly reduce the block caused by lyotropic Au(CN)2- ions applied to the intracellular side of the channel.	Arginine	94-102	CF transmembrane conductance regulator	Homo sapiens	144-148
12787142-3	2003	We have found that the Glu-Leu-Arg-negative CXC chemokines interferon gamma inducible protein 10, monokine induced by interferon gamma, and platelet factor 4, limit fibroblast responsiveness to growth factors, but the functioning of these factors in wound healing remains uncertain.	Arginine	31-34	C-X-C motif chemokine ligand 9	Homo sapiens	98-157
12788385-1	2003	In pressure-overloaded myocardium, our recent study demonstrated cytoskeletal assembly of c-Src and other signaling proteins which was partially mimicked in vitro using adult feline cardiomyocytes embedded in three-dimensional (3D) collagen matrix and stimulated with an integrin-binding Arg-Gly-Asp (RGD) peptide.	Arginine	288-291	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	90-95
12781424-6	2003	The variant Arg allele of p21 was also associated with a significant decrease in p21 mRNA log-expression.	Arginine	12-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-29
12781424-6	2003	The variant Arg allele of p21 was also associated with a significant decrease in p21 mRNA log-expression.	Arginine	12-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	81-84
12649291-0	2003	Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b.	Arginine	19-27	ADP-ribosyltransferase 2b	Rattus norvegicus	78-83
12820970-5	2003	Mutating the conserved arginine in helix 2 reduced LRH-1 receptor activity and coregulator recruitment, consistent with the partial loss-of-function phenotype exhibited by an analogous SF-1 human mutant.	Arginine	23-31	nuclear receptor subfamily 5 group A member 2	Homo sapiens	51-56
12748290-6	2003	We also find that the Src family kinase Hck phosphorylates the Abl and Arg activation loops, leading to an additional twofold stimulation of kinase activity.	Arginine	71-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	22-25
12810105-3	2003	MSCs use two enzymes involved in arginine metabolism to control T-cell responses: inducible nitric oxide synthase (NOS2), which generates nitric oxide (NO) and arginase 1 (Arg1), which depletes the milieu of arginine.	Arginine	33-41	nitric oxide synthase 2	Homo sapiens	115-119
12810105-3	2003	MSCs use two enzymes involved in arginine metabolism to control T-cell responses: inducible nitric oxide synthase (NOS2), which generates nitric oxide (NO) and arginase 1 (Arg1), which depletes the milieu of arginine.	Arginine	208-216	nitric oxide synthase 2	Homo sapiens	115-119
12810105-6	2003	When both enzymes are induced together, peroxynitrites, generated by NOS2 under conditions of limiting arginine, cause activated T lymphocytes to undergo apoptosis.	Arginine	103-111	nitric oxide synthase 2	Homo sapiens	69-73
12704728-3	2003	NO is produced from l-arginine by the enzyme, nitric oxide synthase (NOS), which has three isoforms: endothelial (NOS3), neural (NOS1), and inducible (NOS2).	Arginine	20-30	nitric oxide synthase 2, inducible	Mus musculus	151-155
12787348-1	2003	The Escherichia coli Tat system serves to export folded proteins harbouring an N-terminal twin-arginine signal peptide across the cytoplasmic membrane.	Arginine	95-103	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	21-24
12787348-8	2003	The presence of genes encoding amidases with twin-arginine signal sequences in the genomes of other Gram-negative bacteria suggests that a similar cell envelope defect may be a common feature of tat mutant strains.	Arginine	50-58	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	195-198
12756332-1	2003	In this report, we have investigated the impact of arginine methylation on the Gar1, Nop1, and Nsr1 nucleolar proteins in Saccharomyces cerevisiae.	Arginine	51-59	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	79-83
12756332-1	2003	In this report, we have investigated the impact of arginine methylation on the Gar1, Nop1, and Nsr1 nucleolar proteins in Saccharomyces cerevisiae.	Arginine	51-59	rRNA methyltransferase NOP1	Saccharomyces cerevisiae S288C	85-89
12756332-12	2003	In contrast, arginine methylation is required for the export of the nuclear RNA-binding proteins Npl3p, Hrp1p, and Nab2p.	Arginine	13-21	Hrp1p	Saccharomyces cerevisiae S288C	104-109
12649291-0	2003	Regulatory role of arginine 204 in the catalytic activity of rat alloantigens ART2a and ART2b.	Arginine	19-27	ADP-ribosyltransferase 2b	Rattus norvegicus	88-93
12649291-4	2003	Arginine 204 (Arg204), NH2-terminal to essential glutamate 209 in Region III, is found in ART2b, but not ART2a.	Arginine	0-8	ADP-ribosyltransferase 2b	Rattus norvegicus	90-95
12721369-1	2003	To examine the relationship between folding and export competence by the twin-arginine translocation (Tat) pathway we analyzed the subcellular localization of fusions between a set of eight putative Tat leader peptides and alkaline phosphatase in isogenic Escherichia coli strains that either allow or disfavor the formation of protein disulfide bonds in the cytoplasm.	Arginine	78-86	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	102-105
12742995-3	2003	Because iNOS activity critically depends on the availability of its substrate l-arginine, the present study aims at elucidating iNOS-mediated effects on H2O2-induced apoptosis of cytokine-activated rat aortic endothelial cells (AECs) subject to medium l-arginine concentrations.	Arginine	78-88	nitric oxide synthase 2	Rattus norvegicus	8-12
12742995-3	2003	Because iNOS activity critically depends on the availability of its substrate l-arginine, the present study aims at elucidating iNOS-mediated effects on H2O2-induced apoptosis of cytokine-activated rat aortic endothelial cells (AECs) subject to medium l-arginine concentrations.	Arginine	78-88	nitric oxide synthase 2	Rattus norvegicus	128-132
12742995-3	2003	Because iNOS activity critically depends on the availability of its substrate l-arginine, the present study aims at elucidating iNOS-mediated effects on H2O2-induced apoptosis of cytokine-activated rat aortic endothelial cells (AECs) subject to medium l-arginine concentrations.	Arginine	252-262	nitric oxide synthase 2	Rattus norvegicus	128-132
12742995-4	2003	METHODS AND RESULTS: In cytokine-activated AECs, iNOS activity was found to be half-maximal at 60 micromol/L arginine, which represents the medium serum level in rats but also in humans.	Arginine	109-117	nitric oxide synthase 2	Rattus norvegicus	49-53
12742995-7	2003	Moreover, competition experiments show that iNOS activity is completely dependent on cationic amino acid transporter-mediated arginine uptake.	Arginine	126-134	nitric oxide synthase 2	Rattus norvegicus	44-48
12742995-10	2003	Thus, decreases in systemic arginine concentrations, or locally within atherosclerotic plaques, will impair the endothelial iNOS-mediated stress response and will significantly increase the risk of endothelial dysfunction.	Arginine	28-36	nitric oxide synthase 2	Rattus norvegicus	124-128
12676734-4	2003	These include 1) elevation of cGMP, mediated by sodium nitroprusside (a nitric oxide donor), atrial natriuretic factor, and l-arginine (via nitric oxide synthase); 2) disruption of the actin cytoskeleton; and 3) inhibition of the clathrin-mediated endocytotic arm of the AQP2 recycling pathway by dominant-negative dynamin expression and by membrane cholesterol depletion.	Arginine	124-134	nitric oxide synthase 2	Homo sapiens	140-165
12694305-2	2003	NO is synthesized from the amino acid L-arginine by the action of the NO synthase (NOS), which can be blocked by endogenous inhibitors such as asymmetric dimethylarginine (ADMA).	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	70-81
12606428-2	2003	NO is produced from l-arginine by the enzyme nitric oxide synthase (NOS), which has three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	152-156
12695354-4	2003	To increase the poor oral bioavailability due to its strong basic amidine functionality selected to fit the arginine side pocket of thrombin, the less basic N-hydroxylated amidine was used in addition to an ethyl ester-protecting residue.	Arginine	108-116	coagulation factor II, thrombin	Homo sapiens	132-140
12704156-7	2003	Like the Saccharomyces cerevisiae rhb1 mutant, the Delta rhbA mutant exhibited increased uptake of arginine.	Arginine	99-107	putative GTPase RHB1	Saccharomyces cerevisiae S288C	34-38
12727968-7	2003	Automatic sequencing showed two different activating mutations at codon Arg(201) of GNAS1, a substitution by histidine in two cases and by serine in one case.	Arginine	72-75	GNAS complex locus	Homo sapiens	84-89
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Arginine	79-87	fibroblast growth factor 1	Homo sapiens	35-61
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Arginine	79-87	fibroblast growth factor 1	Homo sapiens	63-68
12756357-1	2003	OBJECTIVES: R136K is a mutation of fibroblast growth factor-1 (FGF-1) in which arginine replaces lysine at the primary thrombin cleavage site.	Arginine	79-87	coagulation factor II, thrombin	Homo sapiens	119-127
12554767-5	2003	Akt activation by estradiol was abrogated by an arginine-to-cysteine mutation in the pleckstrin homology domain of Akt (R25C).	Arginine	48-56	AKT serine/threonine kinase 1	Homo sapiens	0-3
12554767-5	2003	Akt activation by estradiol was abrogated by an arginine-to-cysteine mutation in the pleckstrin homology domain of Akt (R25C).	Arginine	48-56	AKT serine/threonine kinase 1	Homo sapiens	115-118
12578561-3	2003	Serine and arginine are also the residues at positions P"(1) and P"(2) in human kininogen, from which hK1 releases Lys-bradykinin.	Arginine	11-19	kininogen 1	Homo sapiens	119-129
12709047-5	2003	In the liver, where arginine is hydrolyzed to form urea and ornithine, the ASS gene is highly expressed, and hormones and nutrients constitute the major regulating factors: (a) glucocorticoids, glucagon and insulin, particularly, control the expression of this gene both during development and adult life; (b) dietary protein intake stimulates ASS gene expression, with a particular efficiency of specific amino acids like glutamine.	Arginine	20-28	insulin	Homo sapiens	207-214
12792224-2	2003	There is a large body of evidence that the inducible form of the NO synthase enzyme (iNOS) that is responsible for high-output production of NO from l-arginine is up-regulated in various forms of mucosal inflammation.	Arginine	149-159	nitric oxide synthase 2	Homo sapiens	85-89
12692217-6	2003	In this study, we show that expression of inducible nitric oxide synthase (iNOS), which produces NO from L-arginine, is induced in BCECs from PVC-211 MuLV-infected rats.	Arginine	105-115	nitric oxide synthase 2	Rattus norvegicus	42-73
12853038-7	2003	Zebrafish MT-MMPbeta is unique among vertebrate MT-MMPs in that it contains an Arg-Glu-Asp (RED) multiple-repeat motif in its linker region.	Arginine	79-82	matrix metallopeptidase 14b (membrane-inserted)	Danio rerio	10-20
12826063-0	2003	Competition and binding of arginine, imidazole, and aminoguanidine to endothelial nitric oxide synthase: aminoguanidine is a poor model for substrate, intermediate, and arginine analog inhibitor binding.	Arginine	27-35	nitric oxide synthase 3	Homo sapiens	70-103
12815947-6	2003	Higher frequencies of SOD2 allele Val and genotype Val/Val and of SOD3 allele Arg and genotype Arg/Arg were established for group DPN+.	Arginine	78-81	superoxide dismutase 3	Homo sapiens	66-70
12704081-3	2003	Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter.	Arginine	130-133	YY1 transcription factor	Homo sapiens	75-85
12684648-2	2003	A sequence polymorphism at codon 72 of the p53 gene results in either a proline or an arginine and may induce different functional activities.	Arginine	86-94	tumor protein p53	Homo sapiens	43-46
12684648-4	2003	It has been reported that the p53 Arg homozygous genotype could be a potential genetic risk factor for cancer.	Arginine	34-37	tumor protein p53	Homo sapiens	30-33
12684648-8	2003	A significantly higher prevalence of homozygosity for the p53 Arg allele was observed in the patients as compared to the controls.	Arginine	62-65	tumor protein p53	Homo sapiens	58-61
12699619-7	2003	Comparison of monomeric CD4, dimeric CD8, and artificially tetramerized CD4 fusions correlates the copy number of the tail containing the arginine-based signal with 14-3-3 binding, resulting in the surface expression of the membrane protein.	Arginine	138-146	CD4 molecule	Homo sapiens	24-27
12699619-7	2003	Comparison of monomeric CD4, dimeric CD8, and artificially tetramerized CD4 fusions correlates the copy number of the tail containing the arginine-based signal with 14-3-3 binding, resulting in the surface expression of the membrane protein.	Arginine	138-146	CD4 molecule	Homo sapiens	72-75
12680769-8	2003	Csp8 and Csp9 have an additional Arg in this pocket that can further enhance the binding of a P3 Glu, whereas Csp2 has a Glu adjacent to the conserved Arg.	Arginine	151-154	regulator of calcineurin 2	Homo sapiens	110-114
12704081-3	2003	Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter.	Arginine	130-133	YY1 transcription factor	Homo sapiens	87-90
12655043-5	2003	Our results indicate that inhibition of iNOS activity by arginine depletion in stimulated astrocyte cultures occurs via inhibition of translation of iNOS mRNA.	Arginine	57-65	nitric oxide synthase 2	Homo sapiens	149-153
12655043-3	2003	Herein, we report that decreased availability of L-arginine blocked induction of NO production in cytokine-stimulated astrocytes, owing to inhibition of inducible NOS (iNOS) protein expression.	Arginine	49-59	nitric oxide synthase 2	Homo sapiens	153-166
12704081-3	2003	Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter.	Arginine	130-133	YY1 transcription factor	Homo sapiens	177-180
12655043-3	2003	Herein, we report that decreased availability of L-arginine blocked induction of NO production in cytokine-stimulated astrocytes, owing to inhibition of inducible NOS (iNOS) protein expression.	Arginine	49-59	nitric oxide synthase 2	Homo sapiens	168-172
12655043-5	2003	Our results indicate that inhibition of iNOS activity by arginine depletion in stimulated astrocyte cultures occurs via inhibition of translation of iNOS mRNA.	Arginine	57-65	nitric oxide synthase 2	Homo sapiens	40-44
12655043-6	2003	After stimulation by cytokines, uptake of L-arginine negatively regulates the phosphorylation status of the eukaryotic initiation factor (eIF2 alpha), which, in turn, regulates translation of iNOS mRNA.	Arginine	42-52	nitric oxide synthase 2	Homo sapiens	192-196
12655043-8	2003	As the kinase activity of GCN2 is activated by phosphorylation, these findings suggest that GCN2 activity represents a proximal step in the iNOS translational regulation by availability of l-arginine.	Arginine	189-199	nitric oxide synthase 2	Homo sapiens	140-144
12551903-9	2003	Molecular modeling of apoB predicted that Arg(463) was in close proximity to Glu(756) and Asp(456).	Arginine	42-45	apolipoprotein B	Homo sapiens	22-26
12655043-9	2003	These results provide an explanation for the arginine paradox for iNOS and define a distinct mechanism by which a substrate can regulate the activity of its associated enzyme.	Arginine	45-53	nitric oxide synthase 2	Homo sapiens	66-70
12687010-4	2003	Akt phosphorylation by HRG-beta1 was abrogated by an arginine to cysteine mutation (R25C) in the pleckstrin homology (PH) domain of Akt, and HRG-beta1 did not induce Akt phosphorylation in the ER-negative variant of MCF-7, MCF-7/ADR.	Arginine	53-61	AKT serine/threonine kinase 1	Homo sapiens	0-3
12687010-4	2003	Akt phosphorylation by HRG-beta1 was abrogated by an arginine to cysteine mutation (R25C) in the pleckstrin homology (PH) domain of Akt, and HRG-beta1 did not induce Akt phosphorylation in the ER-negative variant of MCF-7, MCF-7/ADR.	Arginine	53-61	AKT serine/threonine kinase 1	Homo sapiens	132-135
12687010-4	2003	Akt phosphorylation by HRG-beta1 was abrogated by an arginine to cysteine mutation (R25C) in the pleckstrin homology (PH) domain of Akt, and HRG-beta1 did not induce Akt phosphorylation in the ER-negative variant of MCF-7, MCF-7/ADR.	Arginine	53-61	AKT serine/threonine kinase 1	Homo sapiens	132-135
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Arginine	31-39	tumor protein p53	Homo sapiens	78-81
12562776-7	2003	Thus, both Arg(440) in IL5 and Gly residues in the conserved segment of TM11 appear to constitute important elements for proper functioning of the putative "pH(i) sensor" of Na(+)/H(+) exchanger 1.	Arginine	11-14	solute carrier family 9 member A1	Homo sapiens	174-196
12711636-15	2003	Considering (a) the different time course of intradermal and subcutaneous PGE(2)-induced hypernociception, (b) the opposite nociceptive effect of intradermal and subcutaneous administration of SIN-1 (db cGMP) as well as the arginine/NO/cGMP pathway, the existence of different subsets of nociceptive primary sensory neurons in which the arginine/NO/cGMP pathway plays opposing roles is suggested.	Arginine	224-232	MAPK associated protein 1	Homo sapiens	193-198
12711636-15	2003	Considering (a) the different time course of intradermal and subcutaneous PGE(2)-induced hypernociception, (b) the opposite nociceptive effect of intradermal and subcutaneous administration of SIN-1 (db cGMP) as well as the arginine/NO/cGMP pathway, the existence of different subsets of nociceptive primary sensory neurons in which the arginine/NO/cGMP pathway plays opposing roles is suggested.	Arginine	337-345	MAPK associated protein 1	Homo sapiens	193-198
12670191-2	2003	In arginine-fed control rats, urinary and/or serum levels of guanidino compounds, nitric oxide (NO), urea, protein, and glucose increased significantly, while the renal activities of the oxygen species-scavenging enzymes superoxide dismutase (SOD) and catalase decreased, compared with casein-fed rats.	Arginine	3-11	catalase	Rattus norvegicus	252-260
12670191-5	2003	Moreover, in rats given green tea polyphenol the SOD and catalase activities suppressed by excessive arginine administration increased dose-dependently, implying the biological defense system was augmented as a result of free radical scavenging.	Arginine	101-109	catalase	Rattus norvegicus	57-65
12648751-2	2003	We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls.	Arginine	89-97	tumor protein p53	Homo sapiens	149-152
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	0-3	ATP binding cassette subfamily B member 1	Homo sapiens	63-67
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	44-47	ATP binding cassette subfamily B member 1	Homo sapiens	63-67
12721111-11	2003	Therefore, we replaced the Arg residue at position 1202 of MRP1 with Gly.	Arginine	27-30	ATP binding cassette subfamily B member 1	Homo sapiens	59-63
12721111-15	2003	The charged amino acid Arg(1202) proximate to TM helix 16 is of critical importance for the GSH-dependent photolabelling of MRP1 with azido AG-A.	Arginine	23-26	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Arginine	31-39	tumor protein p53	Homo sapiens	125-128
12615083-0	2003	In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5"-nucleotidase activities from rat brain synaptosomes.	Arginine	20-30	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	58-66
12639947-6	2003	The results showed that IGF-I could stimulate EVT cell migration in a time- and dose-dependent manner and addition of alphaIR3, Arg-Gly-Asp hexapeptide, and antibody against alpha(v)beta(3) integrin attenuated the IGF-I migratory effect.	Arginine	128-131	insulin like growth factor 1	Homo sapiens	24-29
15621862-5	2003	Another protein with a mass of 30,923 amu was detected along the HPLC pattern and MS data of its tryptic digest suggested that it corresponds to the dimer of Pa, the isoform of PRP-1 with a substitution Arg-Cys at 103 position.	Arginine	203-206	prion protein	Homo sapiens	177-180
12615083-2	2003	In the present study, we investigated the in vitro effects of Arg, NA, AA and HA on NTPDase1 and 5"-nucleotidase activities from synaptosomal cerebral cortex of rats.	Arginine	62-65	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	84-92
12615083-3	2003	The results showed that Arg enhances NTPDase1 activity at the high concentrations tested (1.5 and 3.0mM) for both the ATP and ADP nucleotides.	Arginine	24-27	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	37-45
12649492-8	2003	The binding affinity was increased on Arg substitution in the conserved motif Ia of eIF4A, which probably improves a predicted arginine network to bind RNA substrates.	Arginine	38-41	eukaryotic translation initiation factor 4A1	Homo sapiens	84-89
12653875-6	2003	Stimulated GH responses were evaluated in seven of 11 patients using arginine-insulin and GHRH tests.	Arginine	69-77	insulin	Homo sapiens	78-85
12653875-9	2003	After arginine-insulin challenge, six of seven patients displayed low GH release.	Arginine	6-14	insulin	Homo sapiens	15-22
12653875-10	2003	GH response was higher after GHRH injection compared with both the response to arginine-insulin and to the maximum GH levels in the nocturnal profiles.	Arginine	79-87	insulin	Homo sapiens	88-95
12653875-13	2003	CONCLUSIONS: Our patients with Cushing"s disease evaluated several years after stereotactic radiosurgery as the primary and only treatment, demonstrated severely blunted spontaneous GH secretion and GH response to arginine-insulin.	Arginine	214-222	insulin	Homo sapiens	223-230
12554782-7	2003	Remarkably, the Arg forms part of an unusual buried polar cluster in hTRbeta.	Arginine	16-19	T cell receptor beta locus	Homo sapiens	69-76
12649492-8	2003	The binding affinity was increased on Arg substitution in the conserved motif Ia of eIF4A, which probably improves a predicted arginine network to bind RNA substrates.	Arginine	127-135	eukaryotic translation initiation factor 4A1	Homo sapiens	84-89
12609749-7	2003	High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and L-arginine.	Arginine	124-134	insulin	Homo sapiens	48-55
12679912-6	2003	RESULTS: We found in exon 7 of p53 gene G-T transversion at the third base of codon 249 resulting 249(Arg) - 249(Ser) mutation in 10/25 (40 %) hepatocellular carcinoma cases, 4/20 (20 %) cirrhotics, and 2/30 (7 %) healthy controls.	Arginine	102-105	tumor protein p53	Homo sapiens	31-34
12551939-6	2003	Both the N-terminal region, with the LXXLL motif, and the C-terminal region, with a serine/arginine-rich domain (RS domain), in PGC-1 alpha were required for full activation of CAR.	Arginine	91-99	PPARG coactivator 1 alpha	Homo sapiens	128-139
12628472-1	2003	Nitric oxide (NO) is synthesized from L-arginine by neuronal, endothelial and inducible isoforms of NO synthase (nNOS, eNOS and iNOS, respectively) and is involved in the regulation of a variety of physiological functions, including immune activity.	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	128-132
12556352-2	2003	The insulin response to arginine at fasting (AIR(1)), at 14 mmol/l, and at &gt;25 mmol/l glucose was reduced by 37-50% after 15 and 25% WR (P &lt;or= 0.05).	Arginine	24-32	insulin	Homo sapiens	4-11
12650927-1	2003	The Escherichia coli Tat system serves to export folded proteins harbouring an N-terminal twin-arginine signal peptide across the cytoplasmic membrane.	Arginine	95-103	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	21-24
12525477-3	2003	Recently, we used structural and functional criteria to identify a novel import sequence at Arg(518) on human 5-lipoxygenase (Jones, S. M., Luo, M., Healy, A. M., Peters-Golden, M., and Brock, T. G. (2002) J. Biol.	Arginine	92-95	arachidonate 5-lipoxygenase	Homo sapiens	110-124
12475394-2	2003	Replacement of the VIP-Thr(11) by an Arg(11) in these ligands contributed to their selectivity: Arg(11)-VIP had a 200-fold lower affinity when compared with VIP at VPAC(2) receptors as opposed to 3- to 5-fold higher affinity at VPAC(1) receptors.	Arginine	37-40	vasoactive intestinal peptide	Homo sapiens	104-107
12475394-2	2003	Replacement of the VIP-Thr(11) by an Arg(11) in these ligands contributed to their selectivity: Arg(11)-VIP had a 200-fold lower affinity when compared with VIP at VPAC(2) receptors as opposed to 3- to 5-fold higher affinity at VPAC(1) receptors.	Arginine	37-40	vasoactive intestinal peptide	Homo sapiens	104-107
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide	Homo sapiens	63-66
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide receptor 1	Homo sapiens	96-103
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide	Homo sapiens	127-130
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide receptor 1	Homo sapiens	335-351
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	266-269	vasoactive intestinal peptide receptor 1	Homo sapiens	96-103
12475394-4	2003	Comparison of the ability of VIP analogues to activate adenylate cyclase through chimaeric VPAC(1)/VPAC(2) and VPAC(2)/VPAC(1) receptors indicated that the first extracellular receptor loop carried most of the VPAC(2) receptors" ability to discriminate VIP from Arg(11)-VIP.	Arginine	262-265	vasoactive intestinal peptide	Homo sapiens	29-32
12499371-5	2003	Glu-203 and Tyr-204 interact with arginines in the consensus sequence of PKA substrates at the P-6 and P-2 positions, respectively.	Arginine	34-43	S100 calcium binding protein A12	Homo sapiens	95-106
12618354-2	2003	We tested the hypothesis that L-arginine worsens the damage by acting as a substrate for inducible nitric oxide synthase (iNOS) and increasing the output of this enzyme.	Arginine	30-40	nitric oxide synthase 2, inducible	Mus musculus	89-120
12618354-2	2003	We tested the hypothesis that L-arginine worsens the damage by acting as a substrate for inducible nitric oxide synthase (iNOS) and increasing the output of this enzyme.	Arginine	30-40	nitric oxide synthase 2, inducible	Mus musculus	122-126
12618354-3	2003	iNOS-null mice or wild-type littermates were treated with L-arginine (300 mg/kg; i.p, three times/day) starting 12 h after occlusion of the middle cerebral artery.	Arginine	58-68	nitric oxide synthase 2, inducible	Mus musculus	0-4
12618354-6	2003	Thus, the worsening of ischemic damage produced by L-arginine depends on iNOS.	Arginine	51-61	nitric oxide synthase 2, inducible	Mus musculus	73-77
12618354-7	2003	The findings support the hypothesis that L-arginine worsens ischemic injury by increasing the catalytic output of iNOS and suggest that administration of L-arginine should be avoided in patients with acute stroke.	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	114-118
12519764-10	2003	At high Ca(2+), HSP90 caused the V(max) of eNOS for l-arginine to increase by 2-fold, but the K(m) of eNOS was unchanged.	Arginine	52-62	nitric oxide synthase 3	Homo sapiens	43-47
12645517-3	2003	In addition, TAFIa has been shown to be capable of removing the carboxyl-terminal arginine residues from the anaphylatoxins and bradykinin, thus implying a role for the TAFI pathway in the vascular responses to inflammation.	Arginine	82-90	kininogen 1	Homo sapiens	128-138
12617892-0	2003	Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-arginine mimetics.	Arginine	88-96	coagulation factor II, thrombin	Homo sapiens	6-14
12620851-3	2003	A pro3 ure2 strain expressing a PGK1 promoter-driven PUT2 allele encoding Delta(1)-pyrroline-5-carboxylate dehydrogenase lacking a mitochondrial targeting sequence produced significant cytoplasmic activity, accumulated twice as much intracellular glutamate, and produced twice as much cell mass as the parent when grown anaerobically on limiting arginine as sole nitrogen source.	Arginine	346-354	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	2-6
12419772-7	2003	We then constructed a fusion protein comprising calcineurin Aalpha and TAT, a 12-amino acid-long arginine-rich sequence of the human immunodeficiency virus protein.	Arginine	97-105	serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Oryctolagus cuniculus	48-66
12629117-7	2003	This difference is explained by increased insulin clearance among the athletes during the first 5 min after arginine (81.1% +/- 1.8% vs. 53.6% +/- 4.7%, P &lt; 0.001).	Arginine	108-116	insulin	Homo sapiens	42-49
12590926-0	2003	Differential effects of mutations in human endothelial nitric oxide synthase at residues Tyr-357 and Arg-365 on L-arginine hydroxylation and GN-hydroxy-L-arginine oxidation.	Arginine	112-122	nitric oxide synthase 3	Homo sapiens	43-76
12590926-1	2003	Biosynthesis of nitric oxide (NO) is catalyzed by NO synthase (NOS) through a two-step oxidation of L-arginine (Arg) with formation of an intermediate, GN-hydroxy-L-Arg (NHA).	Arginine	100-110	nitric oxide synthase 2	Homo sapiens	50-61
12590926-1	2003	Biosynthesis of nitric oxide (NO) is catalyzed by NO synthase (NOS) through a two-step oxidation of L-arginine (Arg) with formation of an intermediate, GN-hydroxy-L-Arg (NHA).	Arginine	112-115	nitric oxide synthase 2	Homo sapiens	50-61
12606535-1	2003	The Arg(972) insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic beta-cell stimulus-coupled insulin secretion and survival.	Arginine	4-7	insulin	Homo sapiens	13-20
12628849-2	2003	A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis.	Arginine	60-68	tumor protein p53	Homo sapiens	145-148
12628849-2	2003	A common polymorphism at codon 72 of exon 4 encoding either arginine (Arg) or proline (Pro) has been shown to affect HPV-mediated degradation of p53 in vitro, and may represent a risk factor for HPV-induced carcinogenesis.	Arginine	70-73	tumor protein p53	Homo sapiens	145-148
12628849-7	2003	Among the TP53 amplified samples, the rate of Arg homozygosity in penile SCC was 61% compared with 68% in BL (non-significant (NS)).	Arginine	46-49	tumor protein p53	Homo sapiens	10-14
12809165-5	2003	In obese women, the vascular and rheological responses to L-arginine were significantly lower (p &lt; 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p &lt; 0.01).	Arginine	58-68	tumor necrosis factor	Homo sapiens	232-259
12603839-5	2003	In particular, we have identified that replacement of leucine in position 5, or arginine in position 2 and 4 of the C-terminal apelin peptide, apelin-13, resulted in significant changes in pharmacology.	Arginine	80-88	apelin	Homo sapiens	127-133
12809165-5	2003	In obese women, the vascular and rheological responses to L-arginine were significantly lower (p &lt; 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p &lt; 0.01).	Arginine	58-68	tumor necrosis factor	Homo sapiens	261-270
12809165-5	2003	In obese women, the vascular and rheological responses to L-arginine were significantly lower (p &lt; 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p &lt; 0.01).	Arginine	58-68	interleukin 6	Homo sapiens	276-289
12809165-5	2003	In obese women, the vascular and rheological responses to L-arginine were significantly lower (p &lt; 0.05) at baseline, as compared with non-obese women, indicating endothelial dysfunction; on the contrary, basal concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were significantly higher (p &lt; 0.01).	Arginine	58-68	interleukin 6	Homo sapiens	291-295
12614323-5	2003	The epsilon4 allele of APOE is one of three (epsilon2 epsilon3 and epsilon4) common alleles generated by cysteine/arginine substitutions at two polymorphic sites.	Arginine	114-122	apolipoprotein E	Homo sapiens	23-27
12603839-5	2003	In particular, we have identified that replacement of leucine in position 5, or arginine in position 2 and 4 of the C-terminal apelin peptide, apelin-13, resulted in significant changes in pharmacology.	Arginine	80-88	apelin	Homo sapiens	143-149
12562911-6	2003	Mutating the pore variant C-terminal to the GYG motif in HCN1, A352, to the analogous conserved Asp in K+ channels or Arg in HCN2 produced a significant hyperpolarizing activation shift (by 5-15 mV), slowed gating kinetics (up to 6-fold), and abolished or attenuated gating responses to external K+.	Arginine	118-121	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	125-129
12647276-7	2003	The subjects with the Arg/Arg genotype had significantly higher levels of fasting plasma insulin and triglycerides and an insulin resistance index of homeostasis model assessment (HOMA-R), and significantly smaller LDL particle size than did the subjects with the Trp/Trp genotype.	Arginine	22-25	insulin	Homo sapiens	89-96
12716130-1	2003	As a potential tool for proteomics and protein characterization, in-gel cysteine- and arginine-specific cleavage is demonstrated by means of trypsin or endoproteinase Lys-C for six model proteins (lysozyme, alpha-lactalbumin, beta-lactoglobulin, ribonuclease A, albumin, and transferrin), ranging in size from 14 kDa to 79 kDa.	Arginine	86-94	lactalbumin alpha	Homo sapiens	207-224
12716130-1	2003	As a potential tool for proteomics and protein characterization, in-gel cysteine- and arginine-specific cleavage is demonstrated by means of trypsin or endoproteinase Lys-C for six model proteins (lysozyme, alpha-lactalbumin, beta-lactoglobulin, ribonuclease A, albumin, and transferrin), ranging in size from 14 kDa to 79 kDa.	Arginine	86-94	transferrin	Homo sapiens	275-286
12631734-3	2003	To address this directly, mutant human proinsulin (Arg/Gly(32):Lys/Thr(64)), which cannot be cleaved by conversion endoproteases, was expressed in primary rat islet cells by recombinant adenovirus.	Arginine	51-54	insulin	Homo sapiens	39-49
12647276-7	2003	The subjects with the Arg/Arg genotype had significantly higher levels of fasting plasma insulin and triglycerides and an insulin resistance index of homeostasis model assessment (HOMA-R), and significantly smaller LDL particle size than did the subjects with the Trp/Trp genotype.	Arginine	22-25	insulin	Homo sapiens	122-129
12647276-7	2003	The subjects with the Arg/Arg genotype had significantly higher levels of fasting plasma insulin and triglycerides and an insulin resistance index of homeostasis model assessment (HOMA-R), and significantly smaller LDL particle size than did the subjects with the Trp/Trp genotype.	Arginine	26-29	insulin	Homo sapiens	89-96
12647276-7	2003	The subjects with the Arg/Arg genotype had significantly higher levels of fasting plasma insulin and triglycerides and an insulin resistance index of homeostasis model assessment (HOMA-R), and significantly smaller LDL particle size than did the subjects with the Trp/Trp genotype.	Arginine	26-29	insulin	Homo sapiens	122-129
12632526-8	2003	The concentration of valine was notably increased and the concentration of arginine was markedly decreased in BCAA group after the formula of amino acids enriched BCAA transfusion.	Arginine	75-83	AT-rich interaction domain 4B	Homo sapiens	110-114
12567188-1	2003	The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72.	Arginine	98-106	tumor protein p53	Homo sapiens	9-13
12567188-1	2003	The gene TP53, encoding p53, has a common sequence polymorphism that results in either proline or arginine at amino-acid position 72.	Arginine	98-106	tumor protein p53	Homo sapiens	24-27
12496269-1	2003	Prothrombinase cleaves prothrombin at Arg(271) and Arg(320) to produce thrombin.	Arginine	38-41	coagulation factor II, thrombin	Homo sapiens	23-34
12496269-1	2003	Prothrombinase cleaves prothrombin at Arg(271) and Arg(320) to produce thrombin.	Arginine	38-41	coagulation factor II, thrombin	Homo sapiens	3-11
12496269-1	2003	Prothrombinase cleaves prothrombin at Arg(271) and Arg(320) to produce thrombin.	Arginine	51-54	coagulation factor II, thrombin	Homo sapiens	3-11
12496269-5	2003	Activation kinetics of WT-II, rMZ-II, and rP2-II indicated that the catalytic efficiency of cleavage at Arg(320) was increased by 30,000-fold by the cofactor factor Va, as was the conversion of prothrombin to thrombin.	Arginine	104-107	coagulation factor II, thrombin	Homo sapiens	194-205
12496269-5	2003	Activation kinetics of WT-II, rMZ-II, and rP2-II indicated that the catalytic efficiency of cleavage at Arg(320) was increased by 30,000-fold by the cofactor factor Va, as was the conversion of prothrombin to thrombin.	Arginine	104-107	coagulation factor II, thrombin	Homo sapiens	197-205
12480940-8	2003	Ferrous eNOS(ox), in the presence of l-arginine, is fully functional in forming the tetrahydrobiopterin radical upon mixing with oxygen as demonstrated by rapid-freeze EPR measurements.	Arginine	37-47	nitric oxide synthase 3	Homo sapiens	8-12
12590613-1	2003	Nardilysin (N-arginine dibasic convertase, EC 3.4.24.61) was first identified on the basis of its ability to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys.	Arginine	168-171	nardilysin convertase	Homo sapiens	0-41
12590613-1	2003	Nardilysin (N-arginine dibasic convertase, EC 3.4.24.61) was first identified on the basis of its ability to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys.	Arginine	172-175	nardilysin convertase	Homo sapiens	0-41
12590613-1	2003	Nardilysin (N-arginine dibasic convertase, EC 3.4.24.61) was first identified on the basis of its ability to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys.	Arginine	172-175	nardilysin convertase	Homo sapiens	0-41
12590613-6	2003	Nardilysin also cleaves calcitonin at His-Arg and somatostatin-14 at Cys-Lys.	Arginine	42-45	nardilysin convertase	Homo sapiens	0-10
12458193-0	2003	The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin.	Arginine	16-24	transferrin	Homo sapiens	94-105
12482758-6	2003	AtGC1 contains the arginine or lysine that participates in hydrogen bonding with guanine and the cysteine that confers substrate specificity for GTP.	Arginine	19-27	guanylyl cyclase 1	Arabidopsis thaliana	0-5
12573244-0	2003	Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale).	Arginine	86-94	fibrinogen beta chain	Homo sapiens	124-134
12573244-0	2003	Familial hypofibrinogenaemia associated with heterozygous substitution of a conserved arginine residue; Bbeta255 Arg-->His (Fibrinogen Merivale).	Arginine	113-116	fibrinogen beta chain	Homo sapiens	124-134
12573244-2	2003	Family studies showed the mutations Bbeta255 Arg-->His (Fibrinogen Merivale) and Bbeta148 Lys-->Asn (Fibrinogen Merivale II) were on different alleles and that only the Bbeta255 Arg-->His mutation segregated with hypofibrinogenaemia.	Arginine	45-48	fibrinogen beta chain	Homo sapiens	56-66
12573244-8	2003	Both the Arg and Gly are absolutely conserved, not only in all known Bbeta chains, but also in all homologous alphaE and gamma chains and in all fibrinogen-related proteins.	Arginine	9-12	fibrinogen beta chain	Homo sapiens	145-155
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Arginine	122-132	nitric oxide synthase 2, inducible	Mus musculus	106-110
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Arginine	18-23	angiotensinogen	Rattus norvegicus	65-71
12598935-5	2003	Pretreatment with N(G)-nitro-L-argingie methyl ester (L-NAME), a nitric oxide synthase (NOS) blocker, may inhibit significantly the role of L-Arg on Ang II - and PMA-activated PKC activity.	Arginine	140-145	angiotensinogen	Rattus norvegicus	149-155
12559906-1	2003	We report the cloning of the arginine repressor gene from the psychropiezophilic Gram-negative bacterium Moritella profunda, the purification of its product (ArgR(Mp)), the identification of the operator in the bipolar argECBFGH(A) operon, in vivo repressibility studies, and an in vitro analysis of the repressor-operator interaction, including binding to mutant and heterologous arginine operators.	Arginine	29-37	arginine repressor	Escherichia coli	158-162
12559906-1	2003	We report the cloning of the arginine repressor gene from the psychropiezophilic Gram-negative bacterium Moritella profunda, the purification of its product (ArgR(Mp)), the identification of the operator in the bipolar argECBFGH(A) operon, in vivo repressibility studies, and an in vitro analysis of the repressor-operator interaction, including binding to mutant and heterologous arginine operators.	Arginine	381-389	arginine repressor	Escherichia coli	158-162
12559906-3	2003	Binding of purified hexameric ArgR(Mp) to the control region of the divergent operon proved to be arginine-dependent, sequence-specific, and significantly more sensitive to heat than complex formation with ArgR(Ec).	Arginine	98-106	arginine repressor	Escherichia coli	30-34
12559906-4	2003	ArgR(Mp) binds E.coli arginine operators very efficiently, but hardly recognizes the operator from Bacillus stearothermophilus or Thermotoga maritima.	Arginine	22-30	arginine repressor	Escherichia coli	0-4
12559906-10	2003	ArgR(Mp) binds to one face of the DNA helix and establishes contacts with two major groove segments and the intervening minor groove of each ARG box, whereas the minor groove segment facing the repressor at the center of the operator remains largely uncontacted.	Arginine	141-144	arginine repressor	Escherichia coli	0-4
12559906-11	2003	This pattern is reminiscent of complex formation with the repressors of E.coli and B.stearothermophilus, and suggests that each ARG box is contacted by two ArgR subunits belonging to opposite trimers.	Arginine	128-131	arginine repressor	Escherichia coli	156-160
12565863-1	2003	The C-half of cisplatin resistance-associated overexpressed protein (CROP), an SR-related protein, comprises domains rich in arginine and glutamate residues (RE domain), and is rich in arginine and serine residues (RS domain).	Arginine	125-133	PNN interacting serine and arginine rich protein	Homo sapiens	79-97
12606182-2	2003	Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synthesis.	Arginine	101-111	nitric oxide synthase 2	Homo sapiens	26-30
12446675-5	2003	Mutating the basic charged arginine residues in all four IQ motifs abrogated binding of IQGAP1 to apocalmodulin, but had no effect on its interaction with Ca(2+)/calmodulin.	Arginine	27-35	calmodulin 1	Homo sapiens	101-111
12642227-2	2003	It is produced in vivo from the amino acid L-arginine by a complex family of enzymes termed nitric oxide synthase (NOS).	Arginine	43-53	nitric oxide synthase 2	Homo sapiens	92-113
12775243-9	2003	Administration of L-arginine reversed the effects of L-NAME on the induction of HSP72 and IS (33.5 +/- 4.0%).	Arginine	18-28	heat shock protein family A (Hsp70) member 1A	Homo sapiens	80-85
12547805-3	2003	We have carried out atomic force microscopy measurements of the interaction between alpha(5)beta(1) and a fibronectin fragment derived from the seventh through tenth type III repeats of FN (i.e., FN7-10) containing both the arg-gly-asp (RGD) sequence and the synergy site.	Arginine	224-227	fibronectin 1	Homo sapiens	106-117
12538601-5	2003	A CGA [arginine (Arg)] occurs in porcine DNA, but UGA is shifted one codon to the 5" direction in bovine DNA, suggesting independent evolution of premature stop codons.	Arginine	7-15	chromogranin A	Bos taurus	2-5
12538601-5	2003	A CGA [arginine (Arg)] occurs in porcine DNA, but UGA is shifted one codon to the 5" direction in bovine DNA, suggesting independent evolution of premature stop codons.	Arginine	17-20	chromogranin A	Bos taurus	2-5
12554696-7	2003	Vice versa, treatment of TNF-alpha-exposed animals with either the NO donor l-arginine or the HO-1 inductor hemin mimicked cooling-associated tissue protection except for failure of l-arginine to abrogate the inflammatory leukocyte response.	Arginine	76-86	tumor necrosis factor	Homo sapiens	25-34
12626408-4	2003	Pretreatment of macrophages with galectin-1 resulted in a dose- and time-dependent inhibition of lipopolysaccharide-induced nitric oxide (NO) production, accompanied by a decrease in inducible nitric oxide synthase (iNOS) expression (the classic pathway of L-arginine).	Arginine	257-267	galectin 1	Rattus norvegicus	33-43
12626408-0	2003	Opposite effects of galectin-1 on alternative metabolic pathways of L-arginine in resident, inflammatory, and activated macrophages.	Arginine	68-78	galectin 1	Rattus norvegicus	20-30
12626408-3	2003	To gain insight into the potential mechanisms involved in these effects, we investigated the effects of galectin-1 in L-arginine metabolism of peritoneal rat macrophages.	Arginine	118-128	galectin 1	Rattus norvegicus	104-114
12626408-5	2003	On the other hand, galectin-1 favored the balance toward activation of L-arginase, the alternative metabolic pathway of L-arginine.	Arginine	120-130	galectin 1	Rattus norvegicus	19-29
12855000-3	2003	Peptide Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH(2) is a matrix-metalloproteinase 3 (MMP-3) enzyme substrate that the authors have labeled with a CyDye pair, Cy3/Cy5Q.	Arginine	12-15	matrix metallopeptidase 3	Homo sapiens	68-94
12855000-3	2003	Peptide Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH(2) is a matrix-metalloproteinase 3 (MMP-3) enzyme substrate that the authors have labeled with a CyDye pair, Cy3/Cy5Q.	Arginine	12-15	matrix metallopeptidase 3	Homo sapiens	96-101
12625227-3	2003	A glutamine/arginine (Gln/Arg) polymorphism at amino acid position 192 of PON has been described.	Arginine	26-29	paraoxonase 1	Homo sapiens	74-77
12625227-4	2003	The Arg/Arg genotype is associated with higher serum paraoxonase activity compared to Gln/Gln.	Arginine	4-7	paraoxonase 1	Homo sapiens	53-64
12625227-4	2003	The Arg/Arg genotype is associated with higher serum paraoxonase activity compared to Gln/Gln.	Arginine	8-11	paraoxonase 1	Homo sapiens	53-64
12625227-5	2003	The Arg/Gln genotype is associated with intermediate serum PON activity.	Arginine	4-7	paraoxonase 1	Homo sapiens	59-62
12760422-3	2003	Both residues are phosphorylated to about the same extent and are in the highly conserved segment Asn91-Ile-Val-Thr94-Pro-Arg-Thr97-Pro-Pro-Pro-Ser101 MALDI mass spectrometry before and after ERK2 treatment revealed the addition of two phosphate groups to the protein.	Arginine	122-125	mitogen-activated protein kinase 1	Bos taurus	192-196
12643857-7	2003	Serum levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in the arginine group were markedly higher than those in other groups.	Arginine	88-96	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	16-42
12643857-7	2003	Serum levels of aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in the arginine group were markedly higher than those in other groups.	Arginine	88-96	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	44-47
12589064-8	2003	Rat ykt6, which contains an arginine in its SNARE motif zero-layer, was found to behave like other R-SNAREs in its SNARE assembly properties.	Arginine	28-36	small NF90 (ILF3) associated RNA E	Homo sapiens	44-49
12525616-0	2003	Phosphorylated serine residues and an arginine-rich domain of the moloney murine leukemia virus p12 protein are required for early events of viral infection.	Arginine	38-46	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	96-99
12595960-2	2003	In this study we have examined the effects of a novel N/OFQ analogue [Nphe(1),Arg(14),Lys(15)]N/OFQ NH(2) hereafter referred to as UFP-101.	Arginine	78-81	prepronociceptin	Homo sapiens	54-59
12595960-2	2003	In this study we have examined the effects of a novel N/OFQ analogue [Nphe(1),Arg(14),Lys(15)]N/OFQ NH(2) hereafter referred to as UFP-101.	Arginine	78-81	prepronociceptin	Homo sapiens	94-99
12595960-10	2003	When UFP-101 is compared with its template molecule [Nphe(1)]N/OFQ(1-13)NH(2), Arg(14),Lys(15) substitution produced approximately 1 log greater potency.	Arginine	79-82	prepronociceptin	Homo sapiens	61-66
12586539-1	2003	Nitric oxide synthase (NOS) converts L-arginine as a substrate to form nitric oxide and the "by-product" citrulline.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	0-21
12634924-1	2003	We have reported previously that L-arginine influx into human platelets is mediated by the high-affinity cationic amino acid transport system y(+)L. In the present study we examined the dependency of nitric oxide synthase (NOS) activity on L-arginine transport in platelets isolated from healthy controls and uraemic patients on haemodialysis.	Arginine	33-43	nitric oxide synthase 2	Homo sapiens	200-221
12634924-1	2003	We have reported previously that L-arginine influx into human platelets is mediated by the high-affinity cationic amino acid transport system y(+)L. In the present study we examined the dependency of nitric oxide synthase (NOS) activity on L-arginine transport in platelets isolated from healthy controls and uraemic patients on haemodialysis.	Arginine	240-250	nitric oxide synthase 2	Homo sapiens	200-221
12551867-0	2003	Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels.	Arginine	18-28	endothelin 1	Homo sapiens	48-60
12551867-3	2003	METHODS AND RESULTS: Nine patients with CSX and 14 control subjects underwent a continuous infusion of L-arginine (0.125 g/min) or saline for 120 minutes.	Arginine	103-113	NK2 homeobox 5	Homo sapiens	40-43
12551867-6	2003	At the end of the first hour of infusion, compared with saline, L-arginine infusion increased basal forearm blood flow, nitrite and nitrate (NOx), and forearm cGMP release and decreased endothelin-1.	Arginine	64-74	endothelin 1	Homo sapiens	186-198
12417586-6	2003	Here we describe the systematic substitution of the 13 lysine or arginine residues located within the general RNA-binding domain of hamster LysRS made of 70 residues.	Arginine	65-73	lysyl-tRNA synthetase 1	Homo sapiens	140-145
12504905-0	2003	Arginine of retinoic acid receptor beta which coordinates with the carboxyl group of retinoic acid functions independent of the amino acid residues responsible for retinoic acid receptor subtype ligand specificity.	Arginine	0-8	retinoic acid receptor beta	Homo sapiens	12-39
12504905-5	2003	Our results demonstrate that in RARbeta mutants that acquire either RARalpha or RARgamma ligand specificity the Arg(269) position responsible for coordination with the carboxyl group of retinoids continued to function like that of RARbeta.	Arginine	112-115	retinoic acid receptor beta	Homo sapiens	32-39
12504905-5	2003	Our results demonstrate that in RARbeta mutants that acquire either RARalpha or RARgamma ligand specificity the Arg(269) position responsible for coordination with the carboxyl group of retinoids continued to function like that of RARbeta.	Arginine	112-115	retinoic acid receptor beta	Homo sapiens	231-238
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	320-323	retinoic acid receptor beta	Homo sapiens	79-86
12615358-6	2003	The unique mutations in the glycine-rich domain of the mutant loricrin form arginine-rich nuclear localization sequences (NLSs) that disrupt differentiation of keratinocytes.	Arginine	76-84	loricrin cornified envelope precursor protein	Homo sapiens	62-70
12706644-1	2003	INTRODUCTION: The exchange of Aalpha 16, Arg for Cys or His is the most common molecular defect in dysfibrinogenemia directly affecting the thrombin cleavage site involved in fibrinopeptide A (FPA) release.	Arginine	41-44	coagulation factor II, thrombin	Homo sapiens	140-148
12384501-0	2003	Roles of Met-34, Cys-64, and Arg-75 in the assembly of human connexin 26.	Arginine	29-32	gap junction protein beta 2	Homo sapiens	61-72
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	367-370	retinoic acid receptor beta	Homo sapiens	79-86
12517962-3	2003	The tapasin dependence of HLA class I alleles bearing different residues at position 114 decreases in the order of acidity, with high tapasin dependence for acidic amino acids (aspartic acid and glutamic acid), moderate dependence for neutral amino acids (asparagine and glutamine), and low dependence for basic amino acids (histidine and arginine).	Arginine	339-347	TAP binding protein	Homo sapiens	4-11
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Arginine	269-277	tumor protein p53	Homo sapiens	95-98
12417581-5	2003	Coexpression of basolateral y(+)LAT1-4F2hc increased l-Arg reabsorption and reversed l-Leu transport from (re)absorption to secretion.	Arginine	53-58	solute carrier family 3 member 2	Canis lupus familiaris	37-42
12454802-8	2003	However, among white women, when data were stratified by the number of diseased vessels, the frequency of the PON1 codon 192 Arg/Arg genotype was significantly higher in the group with three-vessel disease than in the other groups (those with one-vessel and two-vessel disease) combined (17.02% vs. 4.58%; P=.0066).	Arginine	125-128	paraoxonase 1	Homo sapiens	110-114
12454802-8	2003	However, among white women, when data were stratified by the number of diseased vessels, the frequency of the PON1 codon 192 Arg/Arg genotype was significantly higher in the group with three-vessel disease than in the other groups (those with one-vessel and two-vessel disease) combined (17.02% vs. 4.58%; P=.0066).	Arginine	129-132	paraoxonase 1	Homo sapiens	110-114
12454802-10	2003	The adjusted odds ratios for the development of three-vessel disease were 2.80 (95% confidence interval 1.06-7.37; P=.038) for PON1 codon 192 Arg/Arg and 3.68 (95% confidence interval 1.26-10.68; P=.017) for PON2 codon 311 Cys/Cys.	Arginine	142-145	paraoxonase 1	Homo sapiens	127-131
12525679-2	2003	Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for cardiovascular disease.	Arginine	70-73	paraoxonase 1	Homo sapiens	38-42
12524231-7	2003	In contrast to apoE/iNOS dko mice without arginine supplementation, lesion areas were increased in apoE/iNOS double-ko mice with arginine supplementation at 24 weeks.	Arginine	129-137	apolipoprotein E	Mus musculus	99-103
12524231-7	2003	In contrast to apoE/iNOS dko mice without arginine supplementation, lesion areas were increased in apoE/iNOS double-ko mice with arginine supplementation at 24 weeks.	Arginine	129-137	nitric oxide synthase 2, inducible	Mus musculus	104-108
12517306-12	2003	CONCLUSION: AtmBAC2 was isolated as a mitochondrial transporter for arginine in Arabidopsis.	Arginine	68-76	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	12-19
12661899-8	2003	Addition of L-arginine (L-arg) reversed the AG effect on IL-6 and MIP-2 expression.	Arginine	12-22	interleukin 6	Rattus norvegicus	57-61
12661899-8	2003	Addition of L-arginine (L-arg) reversed the AG effect on IL-6 and MIP-2 expression.	Arginine	12-17	interleukin 6	Rattus norvegicus	57-61
12846269-4	2003	Recently, high interest has been devoted to a molecular variant of apoA-I, apoA-I(Milano) (apoA-I(M)), characterized by a Cys for Arg substitution and formation of apoA-I(M)/A-I(M) dimers.	Arginine	130-133	apolipoprotein A1	Homo sapiens	67-73
12846269-4	2003	Recently, high interest has been devoted to a molecular variant of apoA-I, apoA-I(Milano) (apoA-I(M)), characterized by a Cys for Arg substitution and formation of apoA-I(M)/A-I(M) dimers.	Arginine	130-133	apolipoprotein A1	Homo sapiens	75-89
12846269-4	2003	Recently, high interest has been devoted to a molecular variant of apoA-I, apoA-I(Milano) (apoA-I(M)), characterized by a Cys for Arg substitution and formation of apoA-I(M)/A-I(M) dimers.	Arginine	130-133	apolipoprotein A1	Homo sapiens	75-81
12846269-4	2003	Recently, high interest has been devoted to a molecular variant of apoA-I, apoA-I(Milano) (apoA-I(M)), characterized by a Cys for Arg substitution and formation of apoA-I(M)/A-I(M) dimers.	Arginine	130-133	apolipoprotein A1	Homo sapiens	75-81
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Arginine	269-277	tumor protein p53	Homo sapiens	172-175
14513722-2	2003	(1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform.	Arginine	269-277	tumor protein p53	Homo sapiens	172-175
12540523-5	2003	Arg(11) and Arg(18) were replaced by serines to give [Ser(11,18)]CGRP(8-37).	Arginine	0-3	calcitonin related polypeptide alpha	Homo sapiens	65-69
12540523-16	2003	It is concluded that the Arg(11) and Arg(18) are involved in specific electrostatic interactions with other residues, either on the CGRP(1) receptors or elsewhere on CGRP(8-37).	Arginine	25-28	calcitonin related polypeptide alpha	Homo sapiens	132-136
12540523-16	2003	It is concluded that the Arg(11) and Arg(18) are involved in specific electrostatic interactions with other residues, either on the CGRP(1) receptors or elsewhere on CGRP(8-37).	Arginine	25-28	calcitonin related polypeptide alpha	Homo sapiens	166-170
12540523-16	2003	It is concluded that the Arg(11) and Arg(18) are involved in specific electrostatic interactions with other residues, either on the CGRP(1) receptors or elsewhere on CGRP(8-37).	Arginine	37-40	calcitonin related polypeptide alpha	Homo sapiens	132-136
12540523-16	2003	It is concluded that the Arg(11) and Arg(18) are involved in specific electrostatic interactions with other residues, either on the CGRP(1) receptors or elsewhere on CGRP(8-37).	Arginine	37-40	calcitonin related polypeptide alpha	Homo sapiens	166-170
12784039-5	2003	NO is generated via constitutive and inducible nitric oxide synthases (iNOS) which catalyze the oxidation of a guanidino nitrogen associated with L-arginine.	Arginine	146-156	nitric oxide synthase 2	Homo sapiens	71-75
12693660-4	2003	In a perifusion system, NICCs responded poorly to a glucose challenge alone, but 10 mmol/L arginine elicited a fourfold increase in insulin secretion and 16.7 mmol/L glucose + 10 mmol/L arginine caused a sevenfold increase in insulin section indicating some sensitivity towards glucose.	Arginine	91-99	insulin	Homo sapiens	132-139
14724366-12	2003	It was concluded that L-Arg, which increases cerebral blood perfusion and improves vasomotions of microvessels by enhancing nitric oxide levels and decreasing endothelin-1 levels in blood, exerts a protective effect on secondary cerebral ischemic injury following experimental SAH.	Arginine	22-27	endothelin 1	Rattus norvegicus	159-171
15618735-1	2003	Hitherto three variant forms of ABCG2 have been documented on the basis of their amino acid moieties (i.e., Arg, Gly, and Thr) at the position 482.	Arginine	108-111	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	32-37
12566597-0	2003	Lack of association between Alzheimer"s disease and Gln-Arg 192 Q/R polymorphism of the PON-1 gene in an Italian population.	Arginine	56-59	paraoxonase 1	Homo sapiens	88-93
12566597-9	2003	These results suggest that the human Gln-Arg 192 Q/R polymorphism of the PON-1 gene is not associated with AD in an Italian population.	Arginine	41-44	paraoxonase 1	Homo sapiens	73-78
15618735-7	2003	In contrast, ABCG2 (Arg-482) transports [(3)H]methotrexate in an ATP-dependent manner; however, no transport activity was observed with the other variants (Gly-482 and Thr-482).	Arginine	20-23	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	13-18
12502675-2	2003	Because L-arginine induces insulin release as glucose does, we tested the hypothesis that L-arginine can also display such an ultradian rhythm.	Arginine	8-18	insulin	Homo sapiens	27-34
12708345-1	2003	In codon 72 of the p53 antioncogene there are two alleles, arginine and proline; the arg/arg genotype has recently been identified as a risk factor for developing of cervicouterine cancer (CuCa) associated to human papillomavirus (HVP) infection.	Arginine	59-67	tumor protein p53	Homo sapiens	19-22
12548303-0	2003	Effect of c-reactive protein and interleukins blood levels in postsurgery arginine-enhanced enteral nutrition in head and neck cancer patients.	Arginine	74-82	C-reactive protein	Homo sapiens	10-28
12548303-3	2003	The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine on c-reactive protein (CRP), interleukin 6 (IL-6) and tumour necrosis factor (TNFalpha) in surgical head and neck cancer patients.	Arginine	87-95	C-reactive protein	Homo sapiens	99-117
12708345-1	2003	In codon 72 of the p53 antioncogene there are two alleles, arginine and proline; the arg/arg genotype has recently been identified as a risk factor for developing of cervicouterine cancer (CuCa) associated to human papillomavirus (HVP) infection.	Arginine	59-62	tumor protein p53	Homo sapiens	19-22
12708345-1	2003	In codon 72 of the p53 antioncogene there are two alleles, arginine and proline; the arg/arg genotype has recently been identified as a risk factor for developing of cervicouterine cancer (CuCa) associated to human papillomavirus (HVP) infection.	Arginine	85-88	tumor protein p53	Homo sapiens	19-22
12708345-5	2003	From 102 analyzed samples, p53-arginine allele corresponded to 67.64% and p53-proline allele corresponded to 32.36%; 47 women (46.10%) were arg/arg homocygotes, 11 women (10.77%) were pro/pro homocygotes, 44 women (43.13%) were arg/pro heterocigotes; the genotype distribution was within the Hardy-Weinberg equilibrium.	Arginine	31-39	tumor protein p53	Homo sapiens	27-30
12493021-3	2003	Type I is an hereditary hypofibrinogenaemia genetically characterized by a mutant variant of the fibrinogen molecule designated as fibrinogen Brescia, consistent with a gamma284 Gly--&gt;Arg mutation.	Arginine	187-190	fibrinogen beta chain	Homo sapiens	97-107
12708345-5	2003	From 102 analyzed samples, p53-arginine allele corresponded to 67.64% and p53-proline allele corresponded to 32.36%; 47 women (46.10%) were arg/arg homocygotes, 11 women (10.77%) were pro/pro homocygotes, 44 women (43.13%) were arg/pro heterocigotes; the genotype distribution was within the Hardy-Weinberg equilibrium.	Arginine	31-34	tumor protein p53	Homo sapiens	27-30
15037822-1	2003	Human serum paraoxonase (PON1) exists in 2 major polymorphic forms: Q (glutamine) or R (arginine) at codon 192.	Arginine	88-96	paraoxonase 1	Homo sapiens	25-29
12767266-5	2003	RESULTS: G--&gt;T transversion at the third base of 249 codon resulting in 249(Arg)--&gt;249(Ser) mutation in exon 7 of p53 gene were found in 11/25(44%) hepatocellular carcinoma cases, 4/20 (20%) cirrhotics, and 2/30 (7%) healthy controls (p&lt;0.01).	Arginine	79-82	tumor protein p53	Homo sapiens	120-123
12496409-7	2003	Because Arg1 and iNOS share L-arginine as a common substrate, our results indicate that L-arginine metabolism in myeloid cells is a potential target for selective intervention in reversing myeloid-induced dysfunction in tumor-bearing hosts.	Arginine	28-38	nitric oxide synthase 2, inducible	Mus musculus	17-21
12635827-4	2003	The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).	Arginine	30-33	tumor protein p53	Homo sapiens	16-19
12635827-4	2003	The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).	Arginine	34-37	tumor protein p53	Homo sapiens	16-19
12635827-4	2003	The genotype of p53 codon 72 (Arg/Arg, Arg/Pro, or Pro/Pro) was determined for all subjects by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).	Arginine	34-37	tumor protein p53	Homo sapiens	16-19
12496409-7	2003	Because Arg1 and iNOS share L-arginine as a common substrate, our results indicate that L-arginine metabolism in myeloid cells is a potential target for selective intervention in reversing myeloid-induced dysfunction in tumor-bearing hosts.	Arginine	88-98	nitric oxide synthase 2, inducible	Mus musculus	17-21
12649568-5	2003	RESULTS: Northern blot analysis showed maximal induction of VMP1 after 24 h remaining high after 48 h of arginine administration.	Arginine	105-113	vacuole membrane protein 1	Rattus norvegicus	60-64
12829875-8	2003	It is thought that nitric oxide synthase catalyses transport of electrons for reactions between molecular oxygen and L-arginine.	Arginine	117-127	nitric oxide synthase 2	Homo sapiens	19-40
12507771-3	2003	Our data demonstrate that arginine uptake is enhanced in APOE4 microglia compared to APOE3 microglia.	Arginine	26-34	apolipoprotein E	Homo sapiens	57-62
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	14-22	apolipoprotein E	Homo sapiens	33-38
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	189-197	apolipoprotein E	Homo sapiens	33-38
12507771-6	2003	This change in microglial arginine transport suggests a potential impact of the APOE4 gene allele on those biochemical pathways such as NO production or cell proliferation to which arginine contributes.	Arginine	26-34	apolipoprotein E	Homo sapiens	80-85
12507771-6	2003	This change in microglial arginine transport suggests a potential impact of the APOE4 gene allele on those biochemical pathways such as NO production or cell proliferation to which arginine contributes.	Arginine	181-189	apolipoprotein E	Homo sapiens	80-85
12643544-2	2003	The enzymes used were trypsin, Lys-C, and Asp-N, which cleave at arginine and lysine residues, lysine, and aspartic acid residues, respectively.	Arginine	65-73	asporin	Homo sapiens	42-47
12707486-1	2003	The reciprocal regulation of arginase and nitric oxide synthase (NOS) in L-arginine-metabolizing pathways has been demonstrated.	Arginine	73-83	nitric oxide synthase 2	Homo sapiens	42-63
12649568-0	2003	VMP1 expression correlates with acinar cell cytoplasmic vacuolization in arginine-induced acute pancreatitis.	Arginine	73-81	vacuole membrane protein 1	Rattus norvegicus	0-4
12506130-5	2003	The recent colocalization of the cationic amino acid transporter CAT-1 (system y(+)), nitric oxide synthase (eNOS), and caveolin-1 in endothelial plasmalemmal caveolae provides a novel mechanism for the regulation of NO production by L-arginine delivery and circulating hormones such insulin and 17beta-estradiol.	Arginine	234-244	caveolin 1	Homo sapiens	120-130
12529543-7	2003	Application of alpha-difluoromethyl-ornithine (-Orn) and/or alpha-difluoromethyl-arginine (-Arg), irreversible inhibitors of the putrescine biosynthesis enzymes Orn decarboxylase (ODC) and Arg decarboxylase, respectively, prevented growth of unpollinated MA/pat-2 ovaries.	Arginine	91-95	ornithine decarboxylase	Solanum lycopersicum	161-178
12509629-0	2003	Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2.	Arginine	45-53	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	77-119
12493827-8	2003	A single additional mutation of arginine to aspartic acid allowed for recovery of native structure and increased the thermal stability of the designed Src-p85 chimera by 18 degrees C. This modification appears to relieve an unfavorable surface electrostatic interaction, demonstrating the importance of surface charge interactions in protein stability.	Arginine	32-40	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
12509629-0	2003	Autoantibodies to dsDNA cross-react with the arginine-glycine-rich domain of heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) and promote methylation of hnRNP A2.	Arginine	45-53	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	121-129
12509629-5	2003	The arginine-glycine-rich domain in hnRNP A2 was found to be the reaction site, and the methylation of hnRNP A2 by PRMT1 (protein arginine methyltransferase 1) was increased by anti-DNA.	Arginine	4-12	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	36-44
12509629-5	2003	The arginine-glycine-rich domain in hnRNP A2 was found to be the reaction site, and the methylation of hnRNP A2 by PRMT1 (protein arginine methyltransferase 1) was increased by anti-DNA.	Arginine	4-12	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	103-111
12518232-6	2003	Therefore, the ER sites for Miy C and Kob A may be located at Glu(353), Arg(394), Met(517) and Gly(521).	Arginine	72-75	estrogen receptor 1	Homo sapiens	15-17
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Arginine	188-196	CREB binding protein	Homo sapiens	4-7
12501193-4	2002	However, the 85 kDa regulatory subunit (p85) of the phosphoinositide 3-kinase (PI-3K) is homologous with the Cdc42GAP and contains the essential arginine residue, but is ineffective as a GAP.	Arginine	145-153	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	52-77
12459171-2	2002	In this report, we addressed the question whether the natural variability at p53 locus (the proline-arginine substitution at codon 72) affects the capacity of peripheral-blood mononuclear cells from healthy subjects to undergo in vitro apoptosis in response to the cytotoxic drug cytosine arabinoside.	Arginine	100-108	tumor protein p53	Homo sapiens	77-80
12488509-6	2002	In vitro experiments have indicated that ART-1, an enzyme also present in the airway epithelium, specifically modifies Arg(14) of the HNP-1, causing the loss of the peptide"s antimicrobial and cytotoxic activity, while preserving its chemotactic activity.	Arginine	119-122	ADP-ribosyltransferase 1	Homo sapiens	41-46
12377763-5	2002	Grafting the alpha(M)(Lys(245)-Arg(261)) sequence converted alpha(L)beta(2) into a fibrinogen-binding protein capable of mediating efficient and specific adhesion similar to that of wild-type alpha(M)beta(2).	Arginine	31-34	fibrinogen beta chain	Homo sapiens	83-93
12460640-4	2002	The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.).	Arginine	134-137	arginine vasopressin	Rattus norvegicus	4-15
12359306-5	2002	Chemical modification of EGFR-JM by using arginine-selective phenylglyoxal or deletion of the basic segment Arg(645)-Arg(657) inhibits the interaction.	Arginine	42-50	epidermal growth factor receptor	Homo sapiens	25-29
12460640-4	2002	The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.).	Arginine	134-137	arginine vasopressin	Rattus norvegicus	142-153
12460640-4	2002	The vasopressin (0.2 nmol/animal)-induced elevation of both catecholamines was significantly attenuated by [d(CH(2))(5)(1),Tyr(Me)(2),Arg(8)]-vasopressin, a selective vasopressin V(1) receptor antagonist, in a dose-dependent manner (0.1 and 0.2 nmol/animal, i.c.v.).	Arginine	134-137	arginine vasopressin	Rattus norvegicus	142-153
12372819-6	2002	Using N-terminal sequencing they were identified as the normal cleavage site Arg(494)-Val(495) and the novel site Arg(424)-His(425) located in the K4 domain of the alpha-chain.	Arginine	77-80	Fc gamma receptor and transporter	Homo sapiens	164-175
12372819-6	2002	Using N-terminal sequencing they were identified as the normal cleavage site Arg(494)-Val(495) and the novel site Arg(424)-His(425) located in the K4 domain of the alpha-chain.	Arginine	114-117	Fc gamma receptor and transporter	Homo sapiens	164-175
12450380-8	2002	In each of the mutants, however, Lys 301 (equivalent to Lys 296 in Tf) changes its conformation to fill the space occupied by Arg 210 Neta2 in wild-type Lf(N), interacting with the two tyrosine ligands Tyr 92 and Tyr 192.	Arginine	126-129	transferrin	Homo sapiens	67-69
12450399-3	2002	A TSP1 monomer contains three TSRs, each with a hydrophobic cluster with three conserved tryptophans (WxxWxxW), a basic cluster with two conserved arginines (RxR), and six conserved cysteines.	Arginine	147-156	thrombospondin 1	Homo sapiens	2-6
12490409-5	2002	L-Arg supplementation enhanced iNOS and NOx expression in the cells.	Arginine	0-5	nitric oxide synthase 2	Homo sapiens	31-35
12490409-8	2002	These results indicated that L-Arg induces iNOS and generates NO, which inhibits EBV reactivation in EBV-positive cells.	Arginine	29-34	nitric oxide synthase 2	Homo sapiens	43-47
12504270-6	2002	Arg administration significantly increased ALP, NO, PICP and IGF-I production and reduced the level of IL-6.	Arginine	0-3	alkaline phosphatase, placental	Homo sapiens	43-46
12504270-6	2002	Arg administration significantly increased ALP, NO, PICP and IGF-I production and reduced the level of IL-6.	Arginine	0-3	insulin like growth factor 1	Homo sapiens	61-66
12504270-6	2002	Arg administration significantly increased ALP, NO, PICP and IGF-I production and reduced the level of IL-6.	Arginine	0-3	interleukin 6	Homo sapiens	103-107
12493091-11	2002	In vivo inhibition of iNOS or ODC decreased ROS production induced by GLN and ARG.	Arginine	78-81	nitric oxide synthase 2	Rattus norvegicus	22-26
12359306-5	2002	Chemical modification of EGFR-JM by using arginine-selective phenylglyoxal or deletion of the basic segment Arg(645)-Arg(657) inhibits the interaction.	Arginine	108-111	epidermal growth factor receptor	Homo sapiens	25-29
12359306-5	2002	Chemical modification of EGFR-JM by using arginine-selective phenylglyoxal or deletion of the basic segment Arg(645)-Arg(657) inhibits the interaction.	Arginine	117-120	epidermal growth factor receptor	Homo sapiens	25-29
12359306-6	2002	Phosphorylation of EGFR-JM by protein kinase C (PKC) or glutamate substitution of Thr(654) inhibits the interaction, suggesting that PKC phosphorylation electrostatically interferes with calmodulin binding to basic arginine residues.	Arginine	215-223	epidermal growth factor receptor	Homo sapiens	19-23
12426349-0	2002	Arginine operator binding by heterologous and chimeric ArgR repressors from Escherichia coli and Bacillus stearothermophilus.	Arginine	0-8	arginine repressor	Escherichia coli	55-59
12496062-1	2002	An Arg/Pro polymorphism in codon 72 of the TP53 gene was analyzed in blood samples from 390 breast and 162 colorectal cancer patients previously investigated for TP53 mutations in their tumors.	Arginine	3-6	tumor protein p53	Homo sapiens	43-47
12470967-1	2002	The regulation of expression of the arginine-recycling enzymes and arginase isoforms in association with inducible nitric oxide synthase (iNOS) in the eye of endotoxin-induced uveitis (EIU) rats is investigated.	Arginine	36-44	nitric oxide synthase 2	Rattus norvegicus	105-136
12470967-1	2002	The regulation of expression of the arginine-recycling enzymes and arginase isoforms in association with inducible nitric oxide synthase (iNOS) in the eye of endotoxin-induced uveitis (EIU) rats is investigated.	Arginine	36-44	nitric oxide synthase 2	Rattus norvegicus	138-142
12464363-9	2002	L-365,260 (3R-(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-yl)-N"-(3-methylphenyl)-urea), a selective CCK(2) receptor antagonist, did not alter the evodiamine-induced inhibition of gastric emptying and gastrointestinal transit.	Arginine	0-2	cholecystokinin B receptor	Rattus norvegicus	124-139
12426349-7	2002	Several lines of observations indicate that the alpha4 helix in the oligomerization domain and the linker peptide can contribute to the recognition of single or double Arg boxes and therefore to the operator DNA-binding specificity in similar but not identical ArgR repressors from two distant bacteria.	Arginine	168-171	arginine repressor	Escherichia coli	261-265
12669678-4	2002	The children with an apo E2E3 genotype (carrying the epsilon 2 allele; arg158--&gt;cys) had lower concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) than those with an apo E4E3 (carrying the epsilon 4 allele; cys112--&gt;arg) or apo E3E3 genotype (homozygous for the parent epsilon 3 allele).	Arginine	71-74	apolipoprotein B	Homo sapiens	164-180
12446172-2	2002	The transport of L-arginine, the substrate for NOS2, is required for sustained NO production by NOS2.	Arginine	17-27	nitric oxide synthase 2, inducible	Mus musculus	47-51
12446172-2	2002	The transport of L-arginine, the substrate for NOS2, is required for sustained NO production by NOS2.	Arginine	17-27	nitric oxide synthase 2, inducible	Mus musculus	96-100
12446172-10	2002	We conclude that NO production in embryonic fibroblasts is only partially dependent on CAT2 and that other compensating transporters provide arginine for NOS2-mediated NO synthesis.	Arginine	141-149	nitric oxide synthase 2, inducible	Mus musculus	154-158
12446178-6	2002	to investigate the competition for arginine between NO synthase and arginase in IL-1beta-treated rat islets.	Arginine	35-43	interleukin 1 beta	Rattus norvegicus	80-88
12446178-10	2002	IL-1beta-induced NO generation was unaffected by ABH at 1.14 mM arginine, but significantly increased at 0.1 and 0.01 mM arginine.	Arginine	64-72	interleukin 1 beta	Rattus norvegicus	0-8
12446178-10	2002	IL-1beta-induced NO generation was unaffected by ABH at 1.14 mM arginine, but significantly increased at 0.1 and 0.01 mM arginine.	Arginine	121-129	interleukin 1 beta	Rattus norvegicus	0-8
12669678-4	2002	The children with an apo E2E3 genotype (carrying the epsilon 2 allele; arg158--&gt;cys) had lower concentrations of low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) than those with an apo E4E3 (carrying the epsilon 4 allele; cys112--&gt;arg) or apo E3E3 genotype (homozygous for the parent epsilon 3 allele).	Arginine	71-74	apolipoprotein B	Homo sapiens	182-187
12324470-7	2002	Among these sequences, Gln(199)-Ala(203), Leu(225)-Leu(230), and Gly(305)-His(309) are important for the binding of both ligands, whereas Arg(144)-Lys(148) is more critical for fibrinogen than for C3bi binding.	Arginine	138-141	fibrinogen beta chain	Homo sapiens	177-187
12542742-12	2002	The change from serine to arginine in the SAND domain of AIRE protein may have a significant effect on AIRE DNA-binding activity.	Arginine	26-34	autoimmune regulator	Homo sapiens	57-61
12542742-12	2002	The change from serine to arginine in the SAND domain of AIRE protein may have a significant effect on AIRE DNA-binding activity.	Arginine	26-34	autoimmune regulator	Homo sapiens	103-107
12688369-5	2002	This model places the carboxyl terminus of CCK adjacent to the amino-terminal tail outside of transmembrane segment 1, the mid-region of the peptide adjacent to the third extracellular loop outside of transmembrane segment 7, and includes a charge-charge interaction between peptide residue tyrosine-sulfate 27 and the arginine residue in the second extracellular loop of the receptor in position 197.	Arginine	319-327	cholecystokinin	Homo sapiens	43-46
12459165-8	2002	This rise in RT activity was partially reversed in aminoguanidine treated cultures by L-arginine, the normal substrate for iNOS.	Arginine	86-96	nitric oxide synthase 2	Homo sapiens	123-127
12429500-0	2002	Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.	Arginine	27-35	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	42-84
12437348-2	2002	Designing inhibitors to specifically target one of the three nitric oxide synthase (NOS) isozymes that form nitric oxide from the L-Arg substrate poses a significant challenge due to the overwhelmingly conserved active sites.	Arginine	130-135	nitric oxide synthase 2	Homo sapiens	61-82
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Arginine	134-137	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
12429500-7	2002	With an aspartic acid at position 58 in 17beta-HSD-3 occupying the equivalent space in the cofactor binding pocket as arginine 224 in glutathione reductase or serine 12 in 17beta-HSD-1, there was an expectation that some of the mutants might use NADH as a cofactor.	Arginine	118-126	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	40-52
12423715-7	2002	Using this strategy, a 610 T&gt;G nucleotide substitution in the alpha-tropomyosin gene (TPM1) was identified resulting in a novel L185R (Leucine [L] to Arginine [R]) missense mutation.	Arginine	153-161	tropomyosin 1	Homo sapiens	65-82
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Arginine	165-168	N-myristoyltransferase 1	Homo sapiens	61-65
12417259-2	2002	DMSO caused a concentration-dependent 10-fold stimulation of hNMT activity in the presence of a pp60(src)-derived peptide substrate (Gly-Ser-Ser-Lys-Ser-Lys-Pro-Lys-Arg).	Arginine	165-168	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
12403623-1	2002	Residue 19 of the parathyroid hormone (PTH) has been shown to play an important role in both binding to and activation of the PTH receptor; specifically, Arg(19)-containing analogues have improved biological function over similar Glu(19) peptides [Shimizu et al.	Arginine	154-157	parathyroid hormone	Homo sapiens	18-37
12169693-1	2002	We identified a novel serine/arginine (SR)-rich-related protein as a binding partner of Clk4 mutant lacking kinase activity (Clk4 K189R) in the two-hybrid screen and designated it Clasp (Clk4-associating SR-related protein).	Arginine	29-37	CDC like kinase 4	Mus musculus	88-92
12169693-1	2002	We identified a novel serine/arginine (SR)-rich-related protein as a binding partner of Clk4 mutant lacking kinase activity (Clk4 K189R) in the two-hybrid screen and designated it Clasp (Clk4-associating SR-related protein).	Arginine	29-37	CDC like kinase 4	Mus musculus	125-129
12417321-1	2002	Arginine residue at position 285 (R285) in the intracellular C-terminal domain of inward rectifier potassium channel Kir2.2 is conserved in many species, but missing in previously reported human Kir2.2 sequences.	Arginine	0-8	potassium inwardly rectifying channel subfamily J member 12	Homo sapiens	117-123
12417321-1	2002	Arginine residue at position 285 (R285) in the intracellular C-terminal domain of inward rectifier potassium channel Kir2.2 is conserved in many species, but missing in previously reported human Kir2.2 sequences.	Arginine	0-8	potassium inwardly rectifying channel subfamily J member 12	Homo sapiens	195-201
12403623-1	2002	Residue 19 of the parathyroid hormone (PTH) has been shown to play an important role in both binding to and activation of the PTH receptor; specifically, Arg(19)-containing analogues have improved biological function over similar Glu(19) peptides [Shimizu et al.	Arginine	154-157	parathyroid hormone	Homo sapiens	39-42
12403623-1	2002	Residue 19 of the parathyroid hormone (PTH) has been shown to play an important role in both binding to and activation of the PTH receptor; specifically, Arg(19)-containing analogues have improved biological function over similar Glu(19) peptides [Shimizu et al.	Arginine	154-157	parathyroid hormone	Homo sapiens	126-129
12403623-5	2002	On the basis of circular dichroism results, the Arg(19) --&gt; Glu(19) mutations within the context of both PTH(1-20) and PTH(1-34) analogues lead to increases in helix content, ranging from a 8-15% increase.	Arginine	48-51	parathyroid hormone	Homo sapiens	108-111
12403623-5	2002	On the basis of circular dichroism results, the Arg(19) --&gt; Glu(19) mutations within the context of both PTH(1-20) and PTH(1-34) analogues lead to increases in helix content, ranging from a 8-15% increase.	Arginine	48-51	parathyroid hormone	Homo sapiens	122-125
12399273-5	2002	OBJECTIVE: Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration.	Arginine	231-239	insulin	Homo sapiens	273-280
12399273-5	2002	OBJECTIVE: Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration.	Arginine	231-239	insulin	Homo sapiens	352-359
12399273-5	2002	OBJECTIVE: Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration.	Arginine	231-239	insulin	Homo sapiens	273-280
12399273-5	2002	OBJECTIVE: Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration.	Arginine	231-239	insulin	Homo sapiens	352-359
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Arginine	97-104	tumor protein p53	Homo sapiens	32-36
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Arginine	97-104	tumor protein p53	Homo sapiens	158-161
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Arginine	106-109	tumor protein p53	Homo sapiens	32-36
12530090-2	2002	The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid codon 72 of the p53 protein.	Arginine	106-109	tumor protein p53	Homo sapiens	158-161
12481980-10	2002	The main importance of Arg is attributed to its role as a precursor for the synthesis of nitric oxide (NO), a free radical molecule that is synthesized in all mammalian cells from L-Arg by NO synthase (NOS).	Arginine	23-26	nitric oxide synthase 2	Homo sapiens	189-200
12213453-1	2002	Solid phase peptide library screening followed by extension of a lead recognition element for binding to a dsDNA sequence (NF binding site of IL6) using solution phase screening, delivered a new DNA binding peptide, Ac-Arg-Ual-Sar-Chi-Chi-Tal-Arg-CONH2.	Arginine	219-222	interleukin 6	Homo sapiens	142-145
12406085-6	2002	Interestingly, the non-rearranged allele of ETV6 in the MT-ALL cell line carries an arginine to histidine (R399H) mutation which affects a conserved amino acid in the ets DNA binding domain.	Arginine	84-92	ETS variant transcription factor 6	Homo sapiens	44-48
12481980-10	2002	The main importance of Arg is attributed to its role as a precursor for the synthesis of nitric oxide (NO), a free radical molecule that is synthesized in all mammalian cells from L-Arg by NO synthase (NOS).	Arginine	180-185	nitric oxide synthase 2	Homo sapiens	189-200
12202491-6	2002	Both of these PP1 isoforms contain an Arg-Pro-Ile/Val-Thr-Pro-Pro-Arg sequence near the C terminus, a known site of phosphorylation by Cdc/Cdk kinases, and phosphorylation attenuates phosphatase activity.	Arginine	38-41	inorganic pyrophosphatase 1	Homo sapiens	14-17
12521230-2	2002	We have developed TaqMan assay systems for the single nucleotide polymorphisms -219G/T, located in the promoter of the apolipoprotein E gene, 113G/C, present in the transcriptional enhancer element of intron 1, 334T/C, determining Cys or Arg as amino acid residue 112 of mature apolipoprotein E, and 472C/T, determining Arg or Cys as residue 158.	Arginine	238-241	apolipoprotein E	Homo sapiens	119-135
12521230-2	2002	We have developed TaqMan assay systems for the single nucleotide polymorphisms -219G/T, located in the promoter of the apolipoprotein E gene, 113G/C, present in the transcriptional enhancer element of intron 1, 334T/C, determining Cys or Arg as amino acid residue 112 of mature apolipoprotein E, and 472C/T, determining Arg or Cys as residue 158.	Arginine	320-323	apolipoprotein E	Homo sapiens	119-135
12376561-6	2002	The actions of IGFBP-3 and -5 on cell attachment to ECM were lost in the presence of a soluble Arg-Gly-Asp (RGD)-containing fibronectin fragment.	Arginine	95-98	fibronectin 1	Homo sapiens	124-135
12376566-5	2002	These data demonstrate that thrombospondin-1-induced cell chemotaxis can be inhibited by a peptide containing the Arg-Gly-Asp motif, a function-blocking alpha(v)beta(3) antibody, a function-blocking integrin-associated protein (IAP) antibody and pertussis toxin, while thrombospondin-1-stimulated DNA synthesis is inhibited by a function-blocking alpha(3)beta(1) antibody.	Arginine	114-117	thrombospondin 1	Homo sapiens	28-44
12445252-1	2002	Recently it has been found that the presence of homozygous arginine polymorphism at codon 72 of p53, represents a significant risk factor in the development of HPV-associated cervical cancer.	Arginine	59-67	tumor protein p53	Homo sapiens	96-99
12445252-4	2002	The aim of the present study was to assess the frequency distribution of the p53 homozygous arginine polymorphism in cervical cancer patients and in a population sample of healthy Israeli Jewish women in order to determine whether the incidence pattern among them is genetically based.	Arginine	92-100	tumor protein p53	Homo sapiens	77-80
12445252-12	2002	It may be assumed that the low incidence of cervical cancer in Israeli Jewish women and the differences between the ethnic groups may be related to the frequency pattern of the homozygous arginine p53 polymorphism	Arginine	188-196	tumor protein p53	Homo sapiens	197-200
12417033-6	2002	Among these putative protein methylacceptors, three are heterogeneous nuclear ribonucleoproteins (hnRNPA2/B1 and hnRNP K) that are reportedly methylated in their arginine- and glycine-rich RGG motifs.	Arginine	162-170	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	98-108
12391223-3	2002	Our previous studies indicated that in IgA2 lacking Cys(133), a disulfide bond forms between the alpha-chain and the L chain when Cys(220) is followed by Arg(221), but not when Cys(220) is followed by Pro(221), suggesting that the Cys in C(H)1 might be involved in disulfide bonding to the L chain.	Arginine	154-157	Fc gamma receptor and transporter	Homo sapiens	97-108
12458344-2	2002	Previous studies have reported that a common polymorphism of the wild type p53 gene at codon 72 of exon 4 (Arg/Arg) is associated with a sevenfold increased risk of HPV-associated cancer compared to Arg/Pro and Pro/Pro polymorphisms.	Arginine	107-110	tumor protein p53	Homo sapiens	75-78
12458344-2	2002	Previous studies have reported that a common polymorphism of the wild type p53 gene at codon 72 of exon 4 (Arg/Arg) is associated with a sevenfold increased risk of HPV-associated cancer compared to Arg/Pro and Pro/Pro polymorphisms.	Arginine	111-114	tumor protein p53	Homo sapiens	75-78
12458344-2	2002	Previous studies have reported that a common polymorphism of the wild type p53 gene at codon 72 of exon 4 (Arg/Arg) is associated with a sevenfold increased risk of HPV-associated cancer compared to Arg/Pro and Pro/Pro polymorphisms.	Arginine	111-114	tumor protein p53	Homo sapiens	75-78
12415579-12	2002	In cells where both arginase II and inducible NO synthase activity occurs, there is a reciprocal regulation, suggesting that agents that induce arginase II in synovial cells could downregulate the levels of NO and divert L-arginine metabolism toward cell proliferation and/or tissue regeneration.	Arginine	221-231	nitric oxide synthase 2	Homo sapiens	20-57
12434294-0	2002	Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes.	Arginine	72-75	tumor protein p53	Homo sapiens	15-18
12429874-4	2002	During arginine infusion, peak plasma insulin was lower in DM1 than in DM2 (p &lt; 0.05) and CON (p &lt; 0.01).	Arginine	7-15	insulin	Homo sapiens	38-45
12429874-9	2002	DISCUSSION: Arginine infusion transiently decreased plasma leptin concentrations both in insulin-deficient and hyperinsulinemic diabetic patients, indicating a direct inhibitory effect of the amino acid but not of insulin or FFAs.	Arginine	12-20	insulin	Homo sapiens	89-96
12434294-0	2002	Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes.	Arginine	132-135	tumor protein p53	Homo sapiens	15-18
12434294-5	2002	p53 Arg/Arg genotype was significantly increased in lung cancer patients compared to normal controls (50% vs 24.2%, P&lt;0.002).	Arginine	4-7	tumor protein p53	Homo sapiens	0-3
12434294-5	2002	p53 Arg/Arg genotype was significantly increased in lung cancer patients compared to normal controls (50% vs 24.2%, P&lt;0.002).	Arginine	8-11	tumor protein p53	Homo sapiens	0-3
12434294-7	2002	Loss of heterozygosity at the TP53 locus was found in 14 out of 27 Arg/Pro patients (51.85%).	Arginine	67-70	tumor protein p53	Homo sapiens	30-34
12434294-9	2002	Our results suggest that p53 codon 72 Arg homozygosity is associated with advanced lung cancer, and that the Arg allele is preferentially retained in patients heterozygous for this polymorphism.	Arginine	38-41	tumor protein p53	Homo sapiens	25-28
12140292-5	2002	Application of these criteria to the putative bipartite nuclear import sequence of 5-lipoxygenase revealed that this region formed an alpha-helix rather than a random coil, that the critical residue arginine 651 serves a structural role, and that mutation of this residue eliminated catalytic activity.	Arginine	199-207	arachidonate 5-lipoxygenase	Homo sapiens	83-97
12392844-4	2002	Nitric oxide (NO) bioactivity was represented by both basal and bradykinin-stimulated cellular cyclic guanosine monophosphate accumulation and L-citrulline conversion from L-arginine.	Arginine	172-182	kininogen 1	Homo sapiens	64-74
12374746-0	2002	Control of CBP co-activating activity by arginine methylation.	Arginine	41-49	CREB binding protein	Homo sapiens	11-14
12374746-6	2002	Here, we report that another domain of CBP is specifically methylated by CARM1 on conserved arginine residues in vitro and in vivo.	Arginine	92-100	CREB binding protein	Homo sapiens	39-42
12356298-2	2002	Recently, we have shown that a molecular determinant for nephrogenic diabetes insipidus, the vasopressin receptor with a substitution at the DRY motif arginine (V2R R137H), is a constitutively desensitized receptor that is unable to couple to G proteins due to its constitutive association with beta-arrestin [Barak, L. S. (2001) Proc.	Arginine	151-159	arginine vasopressin	Homo sapiens	93-104
12163491-6	2002	The Arg(709) and Arg(1018) cleavages occurred at low thrombin concentrations and decreased the K(d) for FXa binding 5- and 3-fold, respectively.	Arginine	4-7	coagulation factor II, thrombin	Homo sapiens	53-61
12163491-6	2002	The Arg(709) and Arg(1018) cleavages occurred at low thrombin concentrations and decreased the K(d) for FXa binding 5- and 3-fold, respectively.	Arginine	17-20	coagulation factor II, thrombin	Homo sapiens	53-61
12163491-7	2002	The Arg(1545) cleavage, being less sensitive to thrombin, decreased the K(d) for FXa binding approximately 20-fold.	Arginine	4-7	coagulation factor II, thrombin	Homo sapiens	48-56
12370443-1	2002	The enzyme dimethylarginine dimethylaminohydrolase (DDAH) hydrolyses asymmetrically methylated arginine residues that are endogenously produced inhibitors of nitric oxide synthases (NOS).	Arginine	19-27	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	52-56
12370443-1	2002	The enzyme dimethylarginine dimethylaminohydrolase (DDAH) hydrolyses asymmetrically methylated arginine residues that are endogenously produced inhibitors of nitric oxide synthases (NOS).	Arginine	19-27	nitric oxide synthase 2	Homo sapiens	158-180
12361482-12	2002	CONCLUSIONS: The human L-threonine 3-dehydrogenase gene is an expressed pseudogene having lost the splice acceptor site preceding exon 6 and codon arginine-214 (CGA) is mutated to a stop codon (TGA).	Arginine	147-155	chromogranin A	Homo sapiens	161-164
12151404-6	2002	A 2-hydroxyethyl adduct was found by mass spectrometry to be present in the Gly(136)-Arg(147) peptide from tryptic digests of AGT reacted with DBE.	Arginine	85-88	angiotensinogen	Homo sapiens	126-129
12367533-3	2002	Substrate proteins are directed to the Tat apparatus by specialized N-terminal signal peptides bearing a consensus twin-arginine sequence motif.	Arginine	120-128	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	39-42
12095415-1	2002	Nardilysin (N-arginine dibasic convertase, or NRDc) is a cytosolic and cell-surface metalloendopeptidase that, in vitro, cleaves substrates upstream of Arg or Lys in basic pairs.	Arginine	152-155	nardilysin convertase	Homo sapiens	0-41
12217887-1	2002	Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin (SS) release.	Arginine	0-8	growth hormone 1	Homo sapiens	20-34
12217887-1	2002	Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin (SS) release.	Arginine	0-8	growth hormone 1	Homo sapiens	36-38
12217887-3	2002	We hypothesized that if the dominant action of IGF-I is to suppress GH release at the level of the pituitary, then the arginine-induced net increase in GH concentration would be unaffected by an IGF-I infusion.	Arginine	119-127	insulin like growth factor 1	Homo sapiens	47-52
12217887-3	2002	We hypothesized that if the dominant action of IGF-I is to suppress GH release at the level of the pituitary, then the arginine-induced net increase in GH concentration would be unaffected by an IGF-I infusion.	Arginine	119-127	growth hormone 1	Homo sapiens	68-70
12217887-3	2002	We hypothesized that if the dominant action of IGF-I is to suppress GH release at the level of the pituitary, then the arginine-induced net increase in GH concentration would be unaffected by an IGF-I infusion.	Arginine	119-127	growth hormone 1	Homo sapiens	152-154
12217887-10	2002	Peak GH concentration on the IGF-I + Arg day was ~45% of that on the Sal + Arg day.	Arginine	37-40	growth hormone 1	Homo sapiens	5-7
12217887-10	2002	Peak GH concentration on the IGF-I + Arg day was ~45% of that on the Sal + Arg day.	Arginine	75-78	growth hormone 1	Homo sapiens	5-7
12217887-11	2002	The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)].	Arginine	14-22	growth hormone 1	Homo sapiens	30-32
12217887-11	2002	The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)].	Arginine	14-22	insulin like growth factor 1	Homo sapiens	91-96
12217887-11	2002	The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)].	Arginine	14-22	insulin like growth factor 1	Homo sapiens	107-112
12217887-11	2002	The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)].	Arginine	67-70	growth hormone 1	Homo sapiens	30-32
12217887-11	2002	The effect of arginine on net GH release was calculated as [(Sal + Arg) - (Sal + Sal)] - [(IGF-I + Arg) - (IGF-I + Sal)].	Arginine	99-102	growth hormone 1	Homo sapiens	30-32
12204800-0	2002	The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.	Arginine	4-7	paraoxonase 1	Homo sapiens	34-38
12204800-15	2002	On the other hand, in subjects with elevated concentration of HDL cholesterol, the presence of carotid atherosclerosis is significantly associated with the arginine variant in position 192 of the PON1 gene.	Arginine	156-164	paraoxonase 1	Homo sapiens	196-200
12095415-1	2002	Nardilysin (N-arginine dibasic convertase, or NRDc) is a cytosolic and cell-surface metalloendopeptidase that, in vitro, cleaves substrates upstream of Arg or Lys in basic pairs.	Arginine	152-155	nardilysin convertase	Homo sapiens	46-50
12241547-12	2002	As expected, the introduction of an Arg residue at P4 and P6 enhanced the release of ANP.	Arginine	36-39	natriuretic peptide A	Homo sapiens	85-88
12381094-5	2002	The intensity of immunostaining for iNOS was increased approximately 1.9-fold compared with the control in the combined enarapril and L-arginine group as well as in the enalapril group.	Arginine	134-144	nitric oxide synthase 2	Rattus norvegicus	36-40
26680888-8	2002	The women who had p53 (Arg/Arg), IRF-1 (T/T) and had experience of first sexual intercourse before the age of 22-years showed a 5.5 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and had experience of first sexual intercourse after the age of 26-years.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
26680888-6	2002	The women who had p53 (Arg/Arg), IRF-1 (T/T) and an education of less than 6 years showed a 14.7 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and an education of more than 15 years.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
26680888-6	2002	The women who had p53 (Arg/Arg), IRF-1 (T/T) and an education of less than 6 years showed a 14.7 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and an education of more than 15 years.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
26680888-7	2002	The women who had p53 (Arg/Arg), p21 (Ser/Ser) and more than 3 children showed a 6.4 fold increased risk of cervical cancer than those women who had p53 (~Pro), p21 (~Arg) and had borne no child.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
26680888-7	2002	The women who had p53 (Arg/Arg), p21 (Ser/Ser) and more than 3 children showed a 6.4 fold increased risk of cervical cancer than those women who had p53 (~Pro), p21 (~Arg) and had borne no child.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
26680888-7	2002	The women who had p53 (Arg/Arg), p21 (Ser/Ser) and more than 3 children showed a 6.4 fold increased risk of cervical cancer than those women who had p53 (~Pro), p21 (~Arg) and had borne no child.	Arginine	27-30	tumor protein p53	Homo sapiens	18-21
26680888-8	2002	The women who had p53 (Arg/Arg), IRF-1 (T/T) and had experience of first sexual intercourse before the age of 22-years showed a 5.5 fold increased risk of cervical cancer than those women who had p53 (~Pro), IRF-1 (~C) and had experience of first sexual intercourse after the age of 26-years.	Arginine	23-26	tumor protein p53	Homo sapiens	18-21
12374781-2	2002	We have already shown that acute (2 min) activation of A2a purinoceptors stimulates NO production in human fetal umbilical vein endothelial cells (1) and now report a key role for p42/p44 mitogen-activated protein kinases (p42/p44MAPK) in the regulation of the l-arginine-nitric oxide (NO) signaling pathway.	Arginine	261-271	cyclin dependent kinase like 1	Homo sapiens	180-183
12360495-8	2002	The patient had a mutation in the lysozyme gene characterized by substitution of the amino acid at position 64 in the mature protein from tryptophan to arginine, previously described in only 1 French family with prominent nephropathy.	Arginine	152-160	lysozyme	Homo sapiens	34-42
12374781-9	2002	Our results provide the first evidence that adenosine stimulates the endothelial cell l-arginine-NO pathway in a Ca2+-insensitive manner involving p42/p44MAPK, with release of NO leading to a membrane hyperpolarization and activation of l-arginine transport.	Arginine	86-96	cyclin dependent kinase like 1	Homo sapiens	147-150
12433061-2	2002	Under certain conditions, macrophagesand certain other cells can produce high concentrations of NO from its precursor L-arginine via inducible nitricoxide synthase (iNOS)pathway.	Arginine	118-128	nitric oxide synthase 2	Rattus norvegicus	165-169
12379490-14	2002	These studies postulate that an arginine-glycine-aspartic acid sequence found on mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Arginine	32-40	growth hormone receptor	Mus musculus	87-91
12356784-12	2002	CONCLUSIONS: These data suggest that oral arginine may increase endothelial nitric oxide synthase (NOS) to increase vascular NO and temporally reduce blood pressure in mildly hypertensive type 2 diabetic patients.	Arginine	42-50	nitric oxide synthase 2	Homo sapiens	76-97
12370279-4	2002	Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release.	Arginine	176-184	insulin	Homo sapiens	195-202
12379490-14	2002	These studies postulate that an arginine-glycine-aspartic acid sequence found on mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Arginine	32-40	growth hormone receptor	Mus musculus	158-162
12368388-2	2002	Serum PON1 activity and PON1-mediated capacity of HDL to prevent lipoprotein oxidation are modulated by two common polymorphisms at positions 192 (Gln--&gt;Arg) and 55 (Leu--&gt;Met) of the PON1 gene.	Arginine	156-159	paraoxonase 1	Homo sapiens	6-10
12244194-1	2002	We recently identified several individuals carrying a missense mutation (G329A; Arg(110)-Gln) in the FUT7 gene encoding fucosyltransferase VII.	Arginine	80-83	fucosyltransferase 7	Homo sapiens	101-105
12244194-1	2002	We recently identified several individuals carrying a missense mutation (G329A; Arg(110)-Gln) in the FUT7 gene encoding fucosyltransferase VII.	Arginine	80-83	fucosyltransferase 7	Homo sapiens	120-142
12368388-2	2002	Serum PON1 activity and PON1-mediated capacity of HDL to prevent lipoprotein oxidation are modulated by two common polymorphisms at positions 192 (Gln--&gt;Arg) and 55 (Leu--&gt;Met) of the PON1 gene.	Arginine	156-159	paraoxonase 1	Homo sapiens	24-28
12368388-2	2002	Serum PON1 activity and PON1-mediated capacity of HDL to prevent lipoprotein oxidation are modulated by two common polymorphisms at positions 192 (Gln--&gt;Arg) and 55 (Leu--&gt;Met) of the PON1 gene.	Arginine	156-159	paraoxonase 1	Homo sapiens	24-28
12359167-0	2002	Skeletal abnormalities and ultrastructural changes of cartilage in transgenic mice expressing a collagen II gene (COL2A1) with a Cys for Arg-alpha1-519 substitution.	Arginine	137-140	collagen, type II, alpha 1	Mus musculus	114-120
12596889-0	2002	Effects of chronic administration of L-arginine on vasoactive responses induced by endothelin-1 and its plasma level in streptozotocin-induced diabetic rats.	Arginine	37-47	endothelin 1	Rattus norvegicus	83-95
12596889-1	2002	To investigate the mechanism underlying increased endothelin-1 (ET-1) release in diabetic rats, we administered L-arginine chronically to streptozotocin (STZ)-induced diabetic rats.	Arginine	112-122	endothelin 1	Rattus norvegicus	50-62
12596889-3	2002	Chronic administration of L-arginine resulted in a significantly higher plasma NOx concentration and a significantly lower plasma ET-1 level at 10 weeks compared with the untreated diabetic group.	Arginine	26-36	endothelin 1	Rattus norvegicus	130-134
12596889-8	2002	The attenuated vasoconstrictor response to ET-1, but not that to methoxamine, was further attenuated by chronic treatment with L-arginine.	Arginine	127-137	endothelin 1	Rattus norvegicus	43-47
12596889-9	2002	We conclude that since chronic L-arginine administration not only reduced the increase in plasma ET-1 levels but also further attenuated the ET-1-induced vasoconstriction without affecting the change in vasodilatation, chronic L-arginine administration could be valuable for the treatment of the symptoms of diabetic mellitus related to ET-1.	Arginine	31-41	endothelin 1	Rattus norvegicus	97-101
12596889-9	2002	We conclude that since chronic L-arginine administration not only reduced the increase in plasma ET-1 levels but also further attenuated the ET-1-induced vasoconstriction without affecting the change in vasodilatation, chronic L-arginine administration could be valuable for the treatment of the symptoms of diabetic mellitus related to ET-1.	Arginine	31-41	endothelin 1	Rattus norvegicus	141-145
12596889-9	2002	We conclude that since chronic L-arginine administration not only reduced the increase in plasma ET-1 levels but also further attenuated the ET-1-induced vasoconstriction without affecting the change in vasodilatation, chronic L-arginine administration could be valuable for the treatment of the symptoms of diabetic mellitus related to ET-1.	Arginine	31-41	endothelin 1	Rattus norvegicus	141-145
12242308-5	2002	We tested predictions deduced from these models by mutagenesis studies and found evidence for novel direct interactions between the E47 helix-loop-helix domain (Arg 357 or Asp 358) and the Pip N terminus (Leu 24).	Arginine	161-164	prolactin induced protein	Homo sapiens	189-192
12359167-1	2002	OBJECTIVE: To examine the mechanism by which the Arg--&gt;Cys 519 mutation causes the clinical phenotype employing transgenic mice that express the mutated human COL2A1.	Arginine	49-52	collagen type II alpha 1 chain	Homo sapiens	162-168
12359167-8	2002	CONCLUSIONS: Expression of a COL2A1 with an Arg--&gt;Cys 519 substitution in transgenic mice causes retardation of skeletal development and ultrastructural alterations in articular cartilage with a profound reduction of the density of the collagen II fibrils in the tissue.	Arginine	44-47	collagen, type II, alpha 1	Mus musculus	29-35
12392614-6	2002	The frequency of arginine at position HLA-DR beta 71 of third hypervariable region significantly increased among patients with AIH versus healthy control (46.9% versus 18.8%, chi(2)=7.14, P=0.008).	Arginine	17-25	major histocompatibility complex, class II, DR beta 1	Homo sapiens	38-41
12471479-20	2002	However, in L-arg control loops, cNOS activity was greater than in the L-NAME group.	Arginine	12-17	nitric oxide synthase 3	Homo sapiens	33-37
12215497-4	2002	The amino acid residues Arg-23 and Arg-36 of CRFBP were identified as the sites of photoincorporation of monofunctional and bifunctional photoprobes designed on the basis of the amino acid sequence of human/rat CRF(6-33).	Arginine	24-27	corticotropin releasing hormone binding protein	Homo sapiens	45-50
12395946-8	2002	This effect was particularly dramatic for the positively charged side-chains Arg, Lys and His, whose significant enhancement of hydrophobicity in the presence of the cyano column contrasted with their increase in hydrophilicity in the presence of the considerably more hydrophobic C18 stationary phase.	Arginine	77-80	Bardet-Biedl syndrome 9	Homo sapiens	281-284
12121981-1	2002	At the primary structure level, the 90-kDa heat shock protein (HSP90) is composed of three regions: the N-terminal (Met(1)-Arg(400)), middle (Glu(401)-Lys(615)), and C-terminal (Asp(621)-Asp(732)) regions.	Arginine	123-126	Hsp90 family chaperone HSC82	Saccharomyces cerevisiae S288C	63-68
12352363-2	2002	Previously, we demonstrated that renal fibrosis was decreased after 2 weeks of unilateral ureteral obstruction in inducible nitric oxide synthase (iNOS) knock-out mice given L-arginine supplemented drinking water.	Arginine	174-184	nitric oxide synthase 2, inducible	Mus musculus	114-145
12352363-2	2002	Previously, we demonstrated that renal fibrosis was decreased after 2 weeks of unilateral ureteral obstruction in inducible nitric oxide synthase (iNOS) knock-out mice given L-arginine supplemented drinking water.	Arginine	174-184	nitric oxide synthase 2, inducible	Mus musculus	147-151
12065086-3	2002	The p53 codon 72 Arg/Pro polymorphism has been suggested to be associated with susceptibility to tobacco-related cancers, but this association remains controversial.	Arginine	17-20	tumor protein p53	Homo sapiens	4-7
12221289-1	2002	Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	0-31
12224952-8	2002	The most potent compound 1n with the pharmacophore motif "His-DPhe-Arg-Trp" was identified as having an EC(50) value of 165 nM at mMC1R, 7600 nM at mMC3R, 650 nM at mMC4R, and 335 nM at mMC5R.	Arginine	67-70	melanocortin 1 receptor	Mus musculus	130-135
12221289-1	2002	Inducible nitric oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	33-37
12215497-4	2002	The amino acid residues Arg-23 and Arg-36 of CRFBP were identified as the sites of photoincorporation of monofunctional and bifunctional photoprobes designed on the basis of the amino acid sequence of human/rat CRF(6-33).	Arginine	35-38	corticotropin releasing hormone binding protein	Homo sapiens	45-50
12220174-0	2002	The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.	Arginine	13-16	endothelin 1	Homo sapiens	33-45
12220174-0	2002	The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.	Arginine	75-78	endothelin 1	Homo sapiens	33-45
12220174-2	2002	Previous studies on KR-ET-1 showed that, in contrast to ET-1, this engineered compound displays a pH-dependent conformational change related to the formation of a stabilizing salt bridge between the Arg(-)(1) and Asp(8) side chains.	Arginine	199-202	endothelin 1	Homo sapiens	23-27
12351936-11	2002	Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4.	Arginine	190-200	interferon gamma	Homo sapiens	46-54
12091378-2	2002	While guanidino-methylated arginines (MA) including asymmetric dimethylarginine (ADMA) and N(G)-methyl-l-arginine (NMA) are potent competitive inhibitors of nitric oxide synthase (NOS) and are released upon protein degradation, it is unknown whether their intracellular concentrations are sufficient to critically regulate neuronal NO production and secondary cellular function or injury.	Arginine	27-36	nitric oxide synthase 2	Homo sapiens	157-178
12230932-4	2002	p12 carrying a lysine residue (p12K) at position 88 of its sequence may be rapidly degraded in the cell via proteasome, whereas p12 with an arginine residue (p12R) at the same position is severalfold more stable.	Arginine	140-148	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	0-3
12118014-8	2002	The converse double mutant, but neither single mutation alone, introduced into an exon B background (arginine to aspartic acid and cysteine to lysine) was able to restore the NCX1.4 regulatory phenotype.	Arginine	101-109	solute carrier family 8 member A1	Rattus norvegicus	175-179
12080062-3	2002	The mutant ETB gene transcripts lacked a 134-bp nucleotide sequence corresponding to exon 5, and some also contained a substitution from A to G at position 950 in exon 4, resulting in an amino acid substitution from glutamine (Q) to arginine (R).	Arginine	233-241	endothelin receptor type B	Homo sapiens	11-14
12207919-3	2002	Here, we detected and sequenced a p67(phox) homolog in Caco-2 almost identical to the neutrophil sequence, except for three nucleotide substitutions, two of which changed lysines 181 and 328 to arginines.	Arginine	194-203	CD33 molecule	Homo sapiens	34-37
12167610-9	2002	This study showed that urea must enter endothelial cells, probably by UT-B, to inhibit L-Arg transport.	Arginine	87-92	solute carrier family 14 member 1 (Kidd blood group)	Rattus norvegicus	70-74
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Arginine	33-36	MUC3	Homo sapiens	200-204
12234472-2	2002	We have developed two methods for detecting polymorphisms at exons 3 (Tyr113--&gt;His) and 4 (His139--&gt;Arg) of the mEH gene based on different melting temperatures (T(m)) of fluorescent-labeled oligonucleotide hybridization probes using single-step assays that combine fluorescence PCR and melting curve analysis (LightCycler methodology).	Arginine	106-109	epoxide hydrolase 1, microsomal	Mus musculus	118-121
12124779-7	2002	Bioactive insulin was stored and then released following stimulation with arginine, peptones, and bombesin-physiological GIP secretagogues.	Arginine	74-82	insulin	Homo sapiens	10-17
12208785-10	2002	When using bradykinin analogues that were either completely or largely ACE-resistant ([Phe(8)psi(CH(2)-NH)Arg(9)]-bradykinin and [deltaPhe(5)]-bradykinin, respectively), the ACE inhibitor-induced shift of the bradykinin CRC was absent, and its ability to reverse desensitization was absent or significantly reduced, respectively.	Arginine	106-109	angiotensin I converting enzyme	Homo sapiens	71-74
12215338-10	2002	CONCLUSION(S): The induction of DNA fragmentation by L-arginine on proliferative endometria suggests that NO may be involved in the endometrial apoptotic process, whose control may be related predominantly to the changes of Bcl-2 expression.	Arginine	53-63	BCL2 apoptosis regulator	Homo sapiens	224-229
12198657-0	2002	Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia.	Arginine	26-29	fibrinogen beta chain	Homo sapiens	6-16
12198657-0	2002	Novel fibrinogen gamma375 Arg-->Trp mutation (fibrinogen aguadilla) causes hepatic endoplasmic reticulum storage and hypofibrinogenemia.	Arginine	26-29	fibrinogen beta chain	Homo sapiens	46-56
12165803-6	2002	In BMP2 gene, AGA right curved arrow AGT transversion in exon 3, converting arginine to serine was detected.	Arginine	76-84	angiotensinogen	Homo sapiens	37-40
12070169-4	2002	Site-directed mutagenesis revealed that the C-terminal region of arrestin-2 mediated beta(2)-adaptin and clathrin interaction with Phe-391 and Arg-395 having an essential role in beta(2)-adaptin binding and LIELD (residues 376-380) having an essential role in clathrin binding.	Arginine	143-146	arrestin beta 1	Homo sapiens	65-75
12352668-8	2002	RESULTS: Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild-type arginine (p16R87P).	Arginine	206-214	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
12352668-8	2002	RESULTS: Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild-type arginine (p16R87P).	Arginine	206-214	cyclin dependent kinase inhibitor 2A	Homo sapiens	129-132
12392781-9	2002	One alternative regulatory mechanism that demonstrates isoform specificity is arginine transport, which is greater in microglia from APOE4 transgenic mice compared to microglia from APOE3 mice.	Arginine	78-86	apolipoprotein E	Homo sapiens	133-138
12392781-9	2002	One alternative regulatory mechanism that demonstrates isoform specificity is arginine transport, which is greater in microglia from APOE4 transgenic mice compared to microglia from APOE3 mice.	Arginine	78-86	apolipoprotein E	Homo sapiens	182-187
12392781-10	2002	Increased transport is consistent with an increased production of NO and may reflect a direct or indirect effect of the APOE genotype on microglial arginine uptake and microglial activation in general.	Arginine	148-156	apolipoprotein E	Mus musculus	120-124
12070159-6	2002	Whereas this perturbation is unique to the activating mutations at Asp-556(6.44), common features to all of the most active LHR mutants are the breakage of the charge-reinforced H-bonding interaction between Arg-442(3.50) and Asp-542(6.30) and the increase in solvent accessibility of the cytosolic extensions of helices 3 and 6, which probably participate in the receptor-G protein interface.	Arginine	208-211	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	124-127
12186546-18	2002	generation occurred, hsp90 caused a more dramatic enhancement of NO synthesis from nNOS as compared to that under normal L-arginine.	Arginine	121-131	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	21-26
12234710-2	2002	Nitric oxide (NO) is generated from L-arginine by nitric oxide synthase (NOS), and immune inflammation involves the activation of NOS in both effector cells and target cells.	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	50-71
12063246-2	2002	The specificity constant for the phosphorylation of GST-Pyk1 and GST-Pyk2 by bovine catalytic subunit was in the range of the value for Leu-Arg-Arg-Ala-Ser-Leu-Gly (Kemptide).	Arginine	140-143	pyruvate kinase CDC19	Saccharomyces cerevisiae S288C	56-60
12176025-4	2002	Site-directed mutagenesis experiments identify the side pocket residues of COX-2, especially Arg-513, as critical determinants of the COX-2 selectivity towards NAGly.	Arginine	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
12176025-4	2002	Site-directed mutagenesis experiments identify the side pocket residues of COX-2, especially Arg-513, as critical determinants of the COX-2 selectivity towards NAGly.	Arginine	93-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
12048190-0	2002	Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5.	Arginine	0-8	karyopherin subunit alpha 1	Homo sapiens	97-113
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Arginine	94-103	androgen receptor	Homo sapiens	152-169
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Arginine	94-103	androgen receptor	Homo sapiens	171-173
12115052-2	2002	Substrate proteins are directed to the Tat apparatus by distinctive N-terminal signal peptides containing a consensus SRRxFLK "twin-arginine" motif.	Arginine	132-140	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	39-42
12153607-12	2002	The GH response to GHRH was inhibited by OGTT (450.7 +/- 81.1 micro g/l/h, P &lt; 0.05) and almost abolished by Li-He (230.0 +/- 63.6 micro g/l/h, P &lt; 0.05) while was markedly potentiated by ARG (2520.4 +/- 425.8 micro g/l/h, P &lt; 0.05).	Arginine	194-197	growth hormone releasing hormone	Homo sapiens	19-23
12163079-2	2002	Spectral differences between sensory rhodopsin and the light-driven proton pump bacteriorhodopsin depend largely upon the repositioning of a conserved arginine residue in the chromophore-binding pocket.	Arginine	151-159	rhodopsin	Homo sapiens	37-46
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Arginine	51-54	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	151-156
12055198-8	2002	N-terminal amino acid sequencing of Pgp tryptic and chymotryptic peptides indicated Arg(680) and Leu(682) as the sites of cleavage, respectively.	Arginine	84-87	ATP binding cassette subfamily B member 1	Homo sapiens	36-39
12142377-7	2002	The p53 codon 72 arginine allele showed a suggestive negative association with cervical cancer (HET, OR = 0.49; 95% CI, 0.14-1.63; homozygotes, OR = 0.35; 95% CI, 0.11-1.17).	Arginine	17-25	tumor protein p53	Homo sapiens	4-7
12643197-6	2002	In contrast, glucagon responses to insulin-induced hypoglycemia are absent from islets transplanted intrahepatically; however, alpha cells within intrahepatic islets are capable of releasing glucagon in response to intravenous arginine.	Arginine	227-235	insulin	Homo sapiens	35-42
12163658-5	2002	The insulin response was closely related to the increase in plasma amino acids, especially leucine, isoleucine, valine, phenylalanine and arginine, regardless of the rate of gastric emptying.	Arginine	138-146	insulin	Homo sapiens	4-11
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Arginine	158-161	tumor protein p53	Homo sapiens	56-59
12144822-10	2002	The p53 genotype distribution indicated that women homozygous for Arg genotype were at a 2.4-fold higher risk for developing HPV16/18-associated cervical carcinomas, compared to those showing heterozygous Pro/Arg genotype (odds ratio 2.4, 95% confidence interval 1.89 to 3.04).	Arginine	66-69	tumor protein p53	Homo sapiens	4-7
12161514-4	2002	One mutation, a maternally inherited R353W mutation, resulted in markedly reduced P450scc activity by the single amino acid substitution, indicating that Arg(353) is a crucial amino acid residue for P450scc activity.	Arginine	154-157	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	82-89
12161514-4	2002	One mutation, a maternally inherited R353W mutation, resulted in markedly reduced P450scc activity by the single amino acid substitution, indicating that Arg(353) is a crucial amino acid residue for P450scc activity.	Arginine	154-157	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	199-206
12177166-6	2002	Finally, substitution of the unique tyrosine residue within the basic helix-loop-helix (bHLH) portion of nuclear SREBPs with arginine, the conserved residue found in all other bHLH proteins, abolishes the transactivity of all SREBPs for SRE, and conversely results in markedly increased activity of SREBP-1 but not activity of SREBP-2 for E-boxes.	Arginine	125-133	sterol regulatory element binding transcription factor 2	Homo sapiens	327-334
12130585-6	2002	Western blot analysis using site-specific antibodies showed that wild-type FGF-23 secreted into conditioned media was partially cleaved between Arg(179) and Ser(180).	Arginine	144-147	fibroblast growth factor 23	Cricetulus griseus	75-81
12130585-14	2002	We conclude that ADHR is caused by hypophosphatemic action of mutant full-length FGF-23 proteins that are resistant to the cleavage between Arg(179) and Ser(180).	Arginine	140-143	fibroblast growth factor 23	Cricetulus griseus	81-87
12145809-9	2002	RESULTS: L-arginine increased somatostatin-14 release in the presence of CCK8 from 4.4% +/- 0.5% to 6.4% +/- 0.4% (P &lt; 0.02), and this was accompanied by NO release from 27 +/- 7 micromol/L to 86 +/- 12 micromol/L (P = 0.001).	Arginine	9-19	somatostatin	Oryctolagus cuniculus	30-42
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Arginine	86-94	tumor protein p53	Homo sapiens	25-28
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Arginine	86-94	tumor protein p53	Homo sapiens	146-149
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Arginine	96-99	tumor protein p53	Homo sapiens	25-28
12144822-2	2002	A common polymorphism of p53 in exon 4 codon 72, resulting in either proline (Pro) or arginine (Arg), affects HPV16/18 E6-mediated degradation of p53 protein in vivo.	Arginine	96-99	tumor protein p53	Homo sapiens	146-149
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Arginine	154-157	tumor protein p53	Homo sapiens	56-59
12144822-7	2002	The frequency of distribution of the three genotypes of p53 codon 72 in a subgroup of the HPV16/18-positive cervical cancer patients was Pro/Pro 0.18 and Arg/Arg 0.26, with the heterozygous Pro/Arg 0.56, differing significantly from the genotype frequency in the normal healthy women (chi(2) = 6.928, df = 2, P &lt; 0.05).	Arginine	158-161	tumor protein p53	Homo sapiens	56-59
12200603-8	2002	RESULTS: A G:C to A:T mutation at codon 175 of p53 resulting in an arginine --&gt; histidine substitution was detected, confirming the clinical diagnosis of LFS.	Arginine	67-75	tumor protein p53	Homo sapiens	47-50
12218590-9	2002	The difference of the area under the curve (AUC) minus baseline AUC (DeltaAUC) for arginine-stimulated GH serum levels at week two was lower than baseline ( &lt; 0.01).	Arginine	83-91	growth hormone 1	Homo sapiens	103-105
12138176-9	2002	Substitution of arginine residues within this motif abolished S1P cleavage, providing robust evidence that S1P is involved in Luman processing.	Arginine	16-24	cAMP responsive element binding protein 3	Homo sapiens	126-131
12355765-0	2002	[Acute insulin response to arginine of pancreatic beta-cell].	Arginine	27-35	insulin	Homo sapiens	7-14
12372699-5	2002	This effect of BK(1-9) (10(-6) M) was mimicked by the B2 agonist [Phe(8)(CH(2)NH)Arg(9)]-bradykinin (10(-5) M) and blocked by the selective B2-receptor antagonist HOE140 (10(-5) M).	Arginine	81-84	kininogen 1	Homo sapiens	89-99
12130744-1	2002	Nitric-oxide synthase (NOS; EC 1.14.13.39) catalyzes the oxidation of L-arginine to nitric oxide (NO(.))	Arginine	70-80	nitric oxide synthase 2	Homo sapiens	0-21
12224426-2	2002	alpha-Lactalbumin, usually resistant to tryptic hydrolysis, aggregated after heating at &gt; or = 85 degrees C. After its denaturation, alpha-lactalbumin was susceptible to tryptic hydrolysis probably because of exposure of its previously hidden tryptic cleavage sites (Lys-X and Arg-X bonds).	Arginine	280-283	lactalbumin alpha	Homo sapiens	0-17
12224426-2	2002	alpha-Lactalbumin, usually resistant to tryptic hydrolysis, aggregated after heating at &gt; or = 85 degrees C. After its denaturation, alpha-lactalbumin was susceptible to tryptic hydrolysis probably because of exposure of its previously hidden tryptic cleavage sites (Lys-X and Arg-X bonds).	Arginine	280-283	lactalbumin alpha	Homo sapiens	136-153
12553744-1	2002	L-arginine is the substrate for endothelial nitric oxide synthase (eNOS), and the precursor for the synthesis of nitric oxide (NO).	Arginine	0-10	nitric oxide synthase 3	Homo sapiens	32-65
12072215-4	2002	At the optimum pH of 5.5, hydrolysis of Z-Phe-Arg-NHMec was three-fold greater than that of Z-Arg-Arg-NHMec suggesting that the proteolytic specificities of the ESP are more like those of papain or cathepsin L, rather than cathepsin B.	Arginine	46-49	cathepsin L	Homo sapiens	198-209
12135349-1	2002	A study of the oxidation of a series of guanidines related to L-arginine (L-Arg) and of various alkyl- and arylguanidines, by recombinant NO-synthase II (NOS II), led us to the discovery of the first non-alpha-amino acid guanidine substrate of NOS, acting as an efficient NO precursor.	Arginine	62-72	nitric oxide synthase 2, inducible	Mus musculus	154-160
11986314-6	2002	The presence of an arginine at the P1 position of trespin"s reactive site loop suggests that trespin inhibits trypsin-like proteinases.	Arginine	19-27	serpin family B member 10	Rattus norvegicus	50-57
12135387-14	2002	Site-directed mutagenesis indicated that residues in the carboxylate-binding region of the COX-2 active site (Arg-120, Tyr-355, and Glu-524) are critical for the binding of the indomethacin conjugates that leads to slow fluorescence enhancement and cyclooxygenase inhibition.	Arginine	110-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	91-96
12135349-1	2002	A study of the oxidation of a series of guanidines related to L-arginine (L-Arg) and of various alkyl- and arylguanidines, by recombinant NO-synthase II (NOS II), led us to the discovery of the first non-alpha-amino acid guanidine substrate of NOS, acting as an efficient NO precursor.	Arginine	74-79	nitric oxide synthase 2, inducible	Mus musculus	154-160
11986314-6	2002	The presence of an arginine at the P1 position of trespin"s reactive site loop suggests that trespin inhibits trypsin-like proteinases.	Arginine	19-27	serpin family B member 10	Rattus norvegicus	93-100
12115545-1	2002	p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix.	Arginine	54-62	tumor protein p53	Homo sapiens	0-3
12115545-1	2002	p53 codon 72, which produces variant proteins with an arginine (Arg) or proline (Pro), has been reported to be associated with cancers of the lung, esophagus and cervix.	Arginine	64-67	tumor protein p53	Homo sapiens	0-3
12101096-4	2002	ChIP analyses also show that this correlates with the presence on the same promoter region of arginine-methylated proteins including histone H4, an in vitro substrate of PRMT5.	Arginine	94-102	protein arginine methyltransferase 5	Homo sapiens	170-175
12095635-5	2002	These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition.	Arginine	88-91	coagulation factor II, thrombin	Homo sapiens	157-165
12197387-1	2002	A chemical modification of single-chain urokinase-type plasminogen activator (scu-PA) with phenylglyoxal under mild conditions resulted in the scu-PA derivatives with various numbers of the modified Arg residues.	Arginine	199-202	plasminogen activator, urokinase	Homo sapiens	40-76
12197387-5	2002	The neutralization of positively charged Arg residues in this cluster decreases the affinity of scu-PA and the double chain urokinase-type plasminogen activator for PAI-1, which results in an enhancement of the stability in plasma and the fibrinolytic efficiency of the activator.	Arginine	41-44	plasminogen activator, urokinase	Homo sapiens	124-160
12089165-1	2002	BACKGROUND: NO synthesized from L-arginine by the constitutive endothelial NO synthase (eNOS) plays a key role in the atherosclerotic process.	Arginine	32-42	nitric oxide synthase 3	Homo sapiens	88-92
12101096-2	2002	Purification of native CERC reveals the presence of the type II arginine methyltransferase PRMT5, which can mono- or symetrically dimethylate arginine residues in proteins.	Arginine	64-72	protein arginine methyltransferase 5	Homo sapiens	91-96
12151791-0	2002	Arginine administration reduces catalase activity in midbrain of rats.	Arginine	0-8	catalase	Rattus norvegicus	32-40
12151791-2	2002	In the present study we investigated the effect of arginine administration on the antioxidant enzyme activities catalase, glutathione peroxidase and superoxide dismutase in rat midbrain.	Arginine	51-59	catalase	Rattus norvegicus	112-120
12151791-5	2002	L-NAME had no effect on catalase activity, but prevented the reduction of this enzyme provoked by arginine, suggesting that NO formation is involved in the reduction of catalase activity caused by the amino acid.	Arginine	98-106	catalase	Rattus norvegicus	169-177
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Arginine	0-8	caspase 3	Homo sapiens	94-103
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Arginine	0-8	BCL2 apoptosis regulator	Homo sapiens	128-133
12150944-0	2002	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL.	Arginine	0-8	BCL2 like 1	Homo sapiens	137-143
11971909-0	2002	Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition.	Arginine	18-26	coagulation factor II, thrombin	Homo sapiens	101-109
12150722-3	2002	We observed the expression of inducible nitric oxide synthase (iNOS) and apoptosis of cells induced by 5-FU with L-Arg added to the medium.	Arginine	113-118	nitric oxide synthase 2	Homo sapiens	30-61
12150722-3	2002	We observed the expression of inducible nitric oxide synthase (iNOS) and apoptosis of cells induced by 5-FU with L-Arg added to the medium.	Arginine	113-118	nitric oxide synthase 2	Homo sapiens	63-67
12086945-14	2002	The acute insulin response to arginine correlated better with transplanted islet mass than acute insulin response to glucose (AIR(g)) and area under the curve for insulin (AUC(i)), but the AIR(g) and AUC(i) were more closely related to glycemic control.	Arginine	30-38	insulin	Homo sapiens	10-17
12084061-1	2002	Previous data showing an increase of receptor binding activity of [R16]VIP, a vasoactive intestinal peptide (VIP) structural analogue containing arginine at the position 16 of its amino acid sequence, have pointed out the importance of a positive charge at this site.	Arginine	145-153	vasoactive intestinal polypeptide	Mus musculus	71-74
12084061-1	2002	Previous data showing an increase of receptor binding activity of [R16]VIP, a vasoactive intestinal peptide (VIP) structural analogue containing arginine at the position 16 of its amino acid sequence, have pointed out the importance of a positive charge at this site.	Arginine	145-153	vasoactive intestinal polypeptide	Mus musculus	109-112
12144687-1	2002	The usefulness of the arginine (Arg) residue at codon 72 of the p53 tumor suppressor gene as a marker for the risk of cervical cancer remains unclear.	Arginine	22-30	tumor protein p53	Homo sapiens	64-67
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	181-184	tumor protein p53	Homo sapiens	34-37
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	181-184	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	181-184	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	181-184	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	243-246	tumor protein p53	Homo sapiens	34-37
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	243-246	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	243-246	tumor protein p53	Homo sapiens	177-180
12221910-1	2002	A polymorphism at codon 72 in the p53 gen has been reported as a potential risk factor to cervical cancer (CC) because human papillomavirus (HPV) is more effective at degrading p53 Arg-72 than p53 Pro-72, making individuals homozygous for p53 Arg-72 seven times more likely to develop HPV-associated CC.	Arginine	243-246	tumor protein p53	Homo sapiens	177-180
12221910-6	2002	Among cases with CC the proportions of the p53 genotypes at codon 72 were 0.05 to proline homozygous, 0.5 to heterozygous, and 0.45 to arginine-homozygous.	Arginine	135-143	tumor protein p53	Homo sapiens	43-46
12221910-9	2002	We conclude than In our population, as other worldwide countries, the homozygous for arginine at codon 72 of the p53 gene is not a risk factor to cervical cancer.	Arginine	85-93	tumor protein p53	Homo sapiens	113-116
12144687-1	2002	The usefulness of the arginine (Arg) residue at codon 72 of the p53 tumor suppressor gene as a marker for the risk of cervical cancer remains unclear.	Arginine	32-35	tumor protein p53	Homo sapiens	64-67
12144687-9	2002	It would appear that, in the absence of HPV 16/18 infections, the Arg allele at codon 72 of the p53 tumor suppressor gene may constitute a risk factor for carcinogenesis of the cervix.	Arginine	66-69	tumor protein p53	Homo sapiens	96-99
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Arginine	30-38	growth hormone 1	Homo sapiens	76-90
12121494-12	2002	As the systemic injection of arginine derivatives that block NOS activity potently augment the ACTH response to circulating pro-inflammatory cytokines or vasopressin, the present findings indicate that the mechanisms responsible for this phenomenon are distinct from those responsible for ACTH released by i.v.	Arginine	29-37	proopiomelanocortin	Homo sapiens	95-99
12121494-12	2002	As the systemic injection of arginine derivatives that block NOS activity potently augment the ACTH response to circulating pro-inflammatory cytokines or vasopressin, the present findings indicate that the mechanisms responsible for this phenomenon are distinct from those responsible for ACTH released by i.v.	Arginine	29-37	arginine vasopressin	Homo sapiens	154-165
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Arginine	255-263	tumor protein p53	Homo sapiens	16-19
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Arginine	255-263	tumor protein p53	Homo sapiens	142-145
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Arginine	255-263	tumor protein p53	Homo sapiens	142-145
12164929-1	2002	Upregulation of p53 protein induces either growth arrest or apoptosis in response to cellular injury This is signaled from a highly conserved p53 domain between codons 64 and 92, where a functional polymorphism results in either a proline (p53-72P) or an arginine (p53-72R) at codon 72.	Arginine	255-263	tumor protein p53	Homo sapiens	142-145
12093449-1	2002	Specific amino acids, such as arginine, lysine and ornithine, can stimulate growth hormone (GH) release when infused intravenously or administered orally.	Arginine	30-38	growth hormone 1	Homo sapiens	92-94
12093449-6	2002	Although one study showed that arginine infusion can heighten the GH response to exercise, no studies found that pre-exercise oral amino acid supplementation augments GH release.	Arginine	31-39	growth hormone 1	Homo sapiens	66-68
11960997-6	2002	Mutation of these target residues (lysine to arginine substitution) profoundly reduced HDAC1-mediated transcriptional repression in reporter assays without affecting HDAC1 ability to associate with mSin3A and eliminated HDAC1-induced cell cycle and apoptotic responses upon overexpression.	Arginine	45-53	histone deacetylase 1	Homo sapiens	87-92
12089072-8	2002	These differences were eliminated after either neutralization of arginine residues on apo E or digestion of matrix with chondroitin ABC lyase, suggesting that chondroitin and/or dermatan sulfate proteoglycans were responsible for apo E-mediated increased binding.	Arginine	65-73	apolipoprotein E	Mus musculus	86-91
12006574-6	2002	Consistent with the need for the interaction between Arg(2) of Ang II and Ang III with Asp(281), substitution of this residue with alanine (D281A) decreased the peptide"s potency without affecting that of Ang IV.	Arginine	53-56	angiotensinogen	Homo sapiens	63-69
11923313-1	2002	The twin-arginine translocation (Tat) pathway exports those precursor proteins to the periplasmic space of bacteria that harbor a twin-arginine (RR) consensus motif in their signal sequences.	Arginine	9-17	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	33-36
12075467-9	2002	(2) The gene expression and the protein synthesis of ANP induced by Ang II (0.1 micromol/L) were inhibited by L-Arg (100 micromol/L).	Arginine	110-115	angiotensinogen	Rattus norvegicus	68-74
12075467-12	2002	However, Ang II enhanced the effect induced by L-Arg.	Arginine	47-52	angiotensinogen	Rattus norvegicus	9-15
12110377-6	2002	Although [Arg(5),Nle(10)]NKA(4-10) was similar in potency to NKA(4-10), it was the only analog to show significantly reduced efficacy.	Arginine	10-13	tachykinin precursor 1	Homo sapiens	25-28
12060767-4	2002	We found that an arginine-specific ADP ribosyltransferase-1 present on airway epithelial cells modifies Arg-14 of alpha defensin-1.	Arginine	104-107	ADP-ribosyltransferase 1	Homo sapiens	35-59
11923313-3	2002	Translocation proceeding at an efficiency of up to 20% occurs specifically via the Tat pathway as indicated by (i) its requirement for elevated levels of the TatABC proteins in the membrane vesicles, (ii) competition by an intact twin-arginine signal peptide, and (iii) susceptibility toward dissipation of the transmembrane H(+) gradient.	Arginine	235-243	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	83-86
12115654-1	2002	Priming specific Th1 immunity by recombinant hepatitis B core antigen (HBcAg) depends on its arginine (Arg)-rich, 34-36-residue-long C terminus, and nucleotides bound to it.	Arginine	93-101	negative elongation factor complex member C/D, Th1l	Mus musculus	17-20
12023942-2	2002	A deficiency of constitutive nitric oxide synthase (cNOS)-derived nitric oxide (NO), due to reduced availability of L-arginine, importantly contributes to allergen-induced airway hyperresponsiveness (AHR) after the early asthmatic reaction (EAR).	Arginine	116-126	nitric oxide synthase, endothelial	Cavia porcellus	52-56
12023942-3	2002	Since cNOS and arginase use L-arginine as a common substrate, we hypothesized that increased arginase activity is involved in the allergen-induced NO deficiency and AHR.	Arginine	28-38	nitric oxide synthase, endothelial	Cavia porcellus	6-10
12023942-14	2002	The results indicate that enhanced arginase activity contributes to allergen-induced deficiency of cNOS-derived NO and AHR after the EAR, presumably by competition with cNOS for the common substrate, L-arginine.	Arginine	200-210	nitric oxide synthase, endothelial	Cavia porcellus	99-103
12023942-14	2002	The results indicate that enhanced arginase activity contributes to allergen-induced deficiency of cNOS-derived NO and AHR after the EAR, presumably by competition with cNOS for the common substrate, L-arginine.	Arginine	200-210	nitric oxide synthase, endothelial	Cavia porcellus	169-173
12019204-0	2002	Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure.	Arginine	37-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	94-113
12019204-0	2002	Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure.	Arginine	37-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	115-121
12019204-0	2002	Increase in urea in conjunction with L-arginine metabolism in the liver leads to induction of cytochrome P450 2E1 (CYP2E1): the role of urea in CYP2E1 induction by acute renal failure.	Arginine	37-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	144-150
12019204-2	2002	The present study was designed to establish the role of plasma urea nitrogen and L-arginine on hepatic CYP2E1 expression in rats or rats with acute renal failure.	Arginine	81-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	103-109
12019204-8	2002	The levels of CYP2E1 protein and mRNA were increased in rats perfused with 25 mM L-arginine for 24 h (i.e., a 4-fold increase).	Arginine	81-91	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	14-20
12019204-9	2002	Hence, L-arginine, which is irreversibly hydrolyzed to urea and ornithine by arginase, also induced hepatic CYP2E1.	Arginine	7-17	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	108-114
12019204-10	2002	The results of the present study provided evidence that increases in plasma urea in conjunction with L-arginine metabolism lead to the induction of CYP2E1 in the liver.	Arginine	101-111	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	148-154
12115654-1	2002	Priming specific Th1 immunity by recombinant hepatitis B core antigen (HBcAg) depends on its arginine (Arg)-rich, 34-36-residue-long C terminus, and nucleotides bound to it.	Arginine	103-106	negative elongation factor complex member C/D, Th1l	Mus musculus	17-20
12063528-4	2002	METHODS: We generated 2 types of recombinant IL-13 proteins, the amino acids of which at 110 were arginine or glutamine, and analyzed the binding affinities with the IL-13 receptors, as well as the stability of the proteins.	Arginine	98-106	interleukin 13	Homo sapiens	45-50
12011992-10	2002	The KOSCC-11 cell line contained a frameshift mutation and the other cell lines harbored an identical p53 mutation at codon 175 from CGC (Arg) to CTC (Leu).	Arginine	138-141	tumor protein p53	Homo sapiens	102-105
11937361-9	2002	In both CPA small middle dot complexes, the phenyl ring in is fitted in the substrate recognition pocket at the S(1)" subsite, and the carboxylate of the inhibitors forms bifurcated hydrogen bonds with the guanidinium moiety of Arg-145 and a hydrogen bond with the guanidinium of Arg-127.	Arginine	228-231	carboxypeptidase A1	Homo sapiens	8-11
11937361-9	2002	In both CPA small middle dot complexes, the phenyl ring in is fitted in the substrate recognition pocket at the S(1)" subsite, and the carboxylate of the inhibitors forms bifurcated hydrogen bonds with the guanidinium moiety of Arg-145 and a hydrogen bond with the guanidinium of Arg-127.	Arginine	280-283	carboxypeptidase A1	Homo sapiens	8-11
12024010-7	2002	The pause sites map to a rare arginine (CGA) codon and to an adjacent threonine (ACA) codon.	Arginine	30-38	chromogranin A	Homo sapiens	40-43
12060398-10	2002	Our results suggest that TP53 arginine/arginine genotype could represent a potential risk factor for the development of squamous cell carcinoma in renal transplant recipients compared to immunocompetent patients.	Arginine	30-38	tumor protein p53	Homo sapiens	25-29
12060398-10	2002	Our results suggest that TP53 arginine/arginine genotype could represent a potential risk factor for the development of squamous cell carcinoma in renal transplant recipients compared to immunocompetent patients.	Arginine	39-47	tumor protein p53	Homo sapiens	25-29
12069499-3	2002	l-Arginine is the sole substrate for iNOS.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	37-41
12134953-6	2002	The substrate specificity of Arg-Gly and Arg-Gly-Asp was determined using purified inducible NO synthase (iNOS).	Arginine	29-32	nitric oxide synthase 2	Rattus norvegicus	83-104
12134953-6	2002	The substrate specificity of Arg-Gly and Arg-Gly-Asp was determined using purified inducible NO synthase (iNOS).	Arginine	29-32	nitric oxide synthase 2	Rattus norvegicus	106-110
12134953-6	2002	The substrate specificity of Arg-Gly and Arg-Gly-Asp was determined using purified inducible NO synthase (iNOS).	Arginine	41-44	nitric oxide synthase 2	Rattus norvegicus	83-104
12134953-6	2002	The substrate specificity of Arg-Gly and Arg-Gly-Asp was determined using purified inducible NO synthase (iNOS).	Arginine	41-44	nitric oxide synthase 2	Rattus norvegicus	106-110
12134953-12	2002	Arg-Gly and Arg-Gly-Asp were found to be direct substrates for iNOS with similar Km and Vmax values to those of Arg.	Arginine	0-3	nitric oxide synthase 2	Rattus norvegicus	63-67
12134953-12	2002	Arg-Gly and Arg-Gly-Asp were found to be direct substrates for iNOS with similar Km and Vmax values to those of Arg.	Arginine	12-15	nitric oxide synthase 2	Rattus norvegicus	63-67
12134953-12	2002	Arg-Gly and Arg-Gly-Asp were found to be direct substrates for iNOS with similar Km and Vmax values to those of Arg.	Arginine	12-15	nitric oxide synthase 2	Rattus norvegicus	63-67
12134953-17	2002	Arginine-containing peptides, through the PepT1 transporter system, can serve as direct substrates of iNOS for the production of NO by AM.	Arginine	0-8	nitric oxide synthase 2	Rattus norvegicus	102-106
11912203-9	2002	Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines.	Arginine	398-407	adiponectin, C1Q and collagen domain containing	Homo sapiens	46-57
12052975-3	2002	Two common polymorphisms in the PON1 gene, the 192 Gln (Q) --&gt; Arg (R) and 55 Leu (L) --&gt; Met (M) substitutions, determine interindividual variation in PON1 activity.	Arginine	66-69	paraoxonase 1	Homo sapiens	32-36
12052975-3	2002	Two common polymorphisms in the PON1 gene, the 192 Gln (Q) --&gt; Arg (R) and 55 Leu (L) --&gt; Met (M) substitutions, determine interindividual variation in PON1 activity.	Arginine	66-69	paraoxonase 1	Homo sapiens	158-162
11912203-9	2002	Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines.	Arginine	398-407	insulin	Homo sapiens	208-215
11988071-12	2002	Significant proportions of arginine and lysine-derived AGEs in albumin modified highly by methylglyoxal, and lysine-derived AGEs in albumin modified highly by glucose, remain to be identified.	Arginine	27-35	albumin	Homo sapiens	63-70
11888672-1	2002	p53 codon 72 Arg homozygosity has been associated with increased risk of developing cervical cancer.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
11888672-6	2002	The distribution of p53 alleles in bladder cancer patients and in controls was statistically significant (P&lt;0.002; odds ratio, 2.67; 95% confidence interval, 1.38-5.20), and homozygosity for arginine at residue 72 was associated with an increased risk for bladder cancer (P&lt;0.00002; odds ratio, 4.69; 95% confidence interval, 2.13-10.41).	Arginine	194-202	tumor protein p53	Homo sapiens	20-23
11888672-9	2002	Our results provide evidence that this p53 polymorphism is implicated in bladder carcinogenesis and that individuals harboring the Arg/Arg genotype have an increased risk of developing bladder cancer.	Arginine	131-134	tumor protein p53	Homo sapiens	39-42
11888672-9	2002	Our results provide evidence that this p53 polymorphism is implicated in bladder carcinogenesis and that individuals harboring the Arg/Arg genotype have an increased risk of developing bladder cancer.	Arginine	135-138	tumor protein p53	Homo sapiens	39-42
11994457-4	2002	While 2DL4 can activate IFN-gamma production, dependent upon the transmembrane arginine, the function of the single ITIM of 2DL4 remains unknown.	Arginine	79-87	interferon gamma	Homo sapiens	24-33
11980473-1	2002	We report the first low-frequency resonance Raman spectra of ferric endothelial nitric oxide synthase (eNOS) holoenzyme, including the frequency of the Fe-S vibration in the presence of the substrate L-arginine.	Arginine	200-210	nitric oxide synthase 3	Homo sapiens	68-101
12019159-8	2002	Indicator variables were created to evaluate the risk for individuals with the following DVs: GSTP1 GG + GSTM1-null and GSTP1 GG + p53 Arg/Pro or Pro/Pro.	Arginine	135-138	tumor protein p53	Homo sapiens	131-134
11861638-10	2002	In vitro experiments using furin and purified EC-SOD suggest that furin proteolytically cleaves EC-SOD in the middle of the polybasic region and then requires an additional carboxypeptidase to remove the remaining lysines and arginines.	Arginine	226-235	superoxide dismutase 3	Homo sapiens	46-52
11861638-11	2002	A mutation in Arg(213) renders EC-SOD resistant to furin processing.	Arginine	14-17	superoxide dismutase 3	Homo sapiens	31-37
11959627-5	2002	Superfused L-arginine hyperpolarized VSMCs from both the control and LHR groups and reversed L-NNA-induced depolarization (-44.5 +/- 1.0 vs. -45.8 +/- 2.1 mV).	Arginine	11-21	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	69-72
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Arginine	34-42	prolactin induced protein	Homo sapiens	128-131
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Arginine	60-68	prolactin induced protein	Homo sapiens	128-131
11964159-3	2002	We tested the ability of an arginine-degrading enzyme to inhibit NO production in mice and to protect mice from the hypotension and lethality that occur after the administration of TNFalpha or endotoxin.	Arginine	28-36	tumor necrosis factor	Mus musculus	181-189
12168882-5	2002	The amino acid residue at this position is either arginine (p53-Arg) or proline (p53-Pro).	Arginine	50-58	tumor protein p53	Homo sapiens	60-63
12168882-5	2002	The amino acid residue at this position is either arginine (p53-Arg) or proline (p53-Pro).	Arginine	64-67	tumor protein p53	Homo sapiens	60-63
12076977-7	2002	The supply of arginine, the sole substrate for NOS, is dependent on cationic amino acid transporters (CATs) that also demonstrate a similar pattern of apoE isoform dependency.	Arginine	14-22	apolipoprotein E	Felis catus	151-155
12076977-8	2002	Although arginine transport is greater in APOE4 microglia, this effect is not limited to tissue macrophages.	Arginine	9-17	apolipoprotein E	Homo sapiens	42-47
12076977-9	2002	Cortical neurons in primary culture from APOE4 transgenic mice exhibit a similar increase in arginine uptake over neurons cultured from APOE3 mice.	Arginine	93-101	apolipoprotein E	Homo sapiens	41-46
12076977-10	2002	The inappropriate levels of arginine transport and of NO in the presence of the APOE4 compared to the APOE3 gene and its products are likely to have significant impact in the CNS.	Arginine	28-36	apolipoprotein E	Homo sapiens	80-85
11947892-3	2002	L-arginine is the substrate for the enzyme nitric oxide synthase (NOS), which is responsible for the endothelial production of nitric oxide.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	43-64
11964159-9	2002	The toxic effects of TNFalpha and endotoxin may be partially inhibited by enzymic degradation of plasma arginine by ADI-SS PEG(20000).	Arginine	104-112	tumor necrosis factor	Mus musculus	21-29
11980565-12	2002	Our results suggest that allicin inhibits iNOS activity through two different mechanisms: at lower concentrations it decreases iNOS mRNA levels, whereas at higher concentrations it inhibits arginine transport through down-regulation of CAT-2 mRNA.	Arginine	190-198	nitric oxide synthase 2	Rattus norvegicus	42-46
11996858-10	2002	Production of TNF-alpha by peritoneal macrophages after stimulation with lipopolysacchride (LPS) was significantly elevated in the Arg group, whereas no response was observed in the control group.	Arginine	131-134	tumor necrosis factor	Mus musculus	14-23
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Arginine	85-93	tumor protein p53	Homo sapiens	35-38
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Arginine	85-93	tumor protein p53	Homo sapiens	158-161
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Arginine	95-98	tumor protein p53	Homo sapiens	35-38
12006537-1	2002	PURPOSE: It is known that a common p53 polymorphism, encodingeither proline (Pro) or arginine (Arg) at residue 72, produces marked change in the structure of p53.	Arginine	95-98	tumor protein p53	Homo sapiens	158-161
12006537-7	2002	RESULTS: There was a bias to mutate and express the Arg allele in the p53 -mutated TCCs arising in individuals with heterozygosity (Pro/Arg).	Arginine	52-55	tumor protein p53	Homo sapiens	70-73
12006537-7	2002	RESULTS: There was a bias to mutate and express the Arg allele in the p53 -mutated TCCs arising in individuals with heterozygosity (Pro/Arg).	Arginine	136-139	tumor protein p53	Homo sapiens	70-73
11978638-0	2002	Insulin secretory function is impaired in isolated human islets carrying the Gly(972)--&gt;Arg IRS-1 polymorphism.	Arginine	91-94	insulin	Homo sapiens	0-7
11978638-7	2002	Proinsulin release mirrored insulin secretion, and the insulin-to-proinsulin ratio in response to arginine was significantly lower from Arg(972) IRS-1 islets than from control islets.	Arginine	98-106	insulin	Homo sapiens	66-76
11978638-7	2002	Proinsulin release mirrored insulin secretion, and the insulin-to-proinsulin ratio in response to arginine was significantly lower from Arg(972) IRS-1 islets than from control islets.	Arginine	136-139	insulin	Homo sapiens	66-76
11978638-10	2002	In conclusion, Arg(972) IRS-1 islets have reduced insulin content, impaired insulin secretion, and a lower amount of mature secretory granules.	Arginine	15-18	insulin	Homo sapiens	50-57
12062406-6	2002	Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes.	Arginine	44-47	fibrinogen beta chain	Homo sapiens	73-83
12193970-0	2002	[Fibrinogen variation: a heterozygote dysfibrinogenemia with Arg--&gt;His substitution in position 16 of the Aalpha chain].	Arginine	61-64	fibrinogen beta chain	Homo sapiens	1-11
11971019-4	2002	Arginase competes with iNOS by converting L-arginine to L-ornithine.	Arginine	42-52	nitric oxide synthase 2, inducible	Mus musculus	23-27
11988505-4	2002	The mature C terminus of the beta subunit is trimmed by Kex1p, which removes the terminal Arg(345) residue, thus uncovering the toxin"s endoplasmic reticulum targeting signal (HDEL) which--in a sensitive target cell--is essential for retrograde toxin transport.	Arginine	90-93	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	56-61
12052142-2	2002	The PON1 activity polymorphism is determined mainly by a glutamine(Q)/arginine(R) substitution at position 192 of PON1 (PON1(Q192R)).	Arginine	70-78	paraoxonase 1	Homo sapiens	4-8
12052142-2	2002	The PON1 activity polymorphism is determined mainly by a glutamine(Q)/arginine(R) substitution at position 192 of PON1 (PON1(Q192R)).	Arginine	70-78	paraoxonase 1	Homo sapiens	114-118
12052142-2	2002	The PON1 activity polymorphism is determined mainly by a glutamine(Q)/arginine(R) substitution at position 192 of PON1 (PON1(Q192R)).	Arginine	70-78	paraoxonase 1	Homo sapiens	114-118
11900957-2	2002	However, arginase is an other enzyme able to metabolize the substrate L-arginine, and the two enzymes are alternatively regulated by Th1 and Th2 cytokines in murine macrophages.	Arginine	70-80	negative elongation factor complex member C/D, Th1l	Mus musculus	133-136
11966977-6	2002	For these peptides, the affinity and activity at all three human receptors (MC3R, MC4R and MC5R) decreased significantly, demonstrating that the His-Phe-Arg-Trp sequence in gamma-MSH is important for activity at these three melanocortin receptors.	Arginine	153-156	proopiomelanocortin	Homo sapiens	173-182
11966977-8	2002	This study highlights the role played by the His-Phe-Arg-Trp sequence in receptor binding and in agonist activity of gamma-MSH.	Arginine	53-56	proopiomelanocortin	Homo sapiens	117-126
11961122-1	2002	Insight into the molecular basis of cholecystokinin (CCK) binding to its receptor has come from receptor mutagenesis and photoaffinity labeling studies, with both contributing to the current hypothesis that the acidic Tyr-sulfate-27 residue within the peptide is situated adjacent to basic Arg(197) in the second loop of the receptor.	Arginine	290-293	cholecystokinin	Homo sapiens	36-51
11961122-1	2002	Insight into the molecular basis of cholecystokinin (CCK) binding to its receptor has come from receptor mutagenesis and photoaffinity labeling studies, with both contributing to the current hypothesis that the acidic Tyr-sulfate-27 residue within the peptide is situated adjacent to basic Arg(197) in the second loop of the receptor.	Arginine	290-293	cholecystokinin	Homo sapiens	53-56
11934589-0	2002	Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates.	Arginine	82-90	coagulation factor II, thrombin	Homo sapiens	13-21
12062406-6	2002	Further experiments showed that the peptide Arg-Gly-Asp-Ser blocked both fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to the erythrocyte membranes.	Arginine	44-47	fibrinogen beta chain	Homo sapiens	151-161
11827968-2	2002	We have reported that alpha1:Ser(2091)-Arg(2108), a peptide derived from the alpha1-chain of laminin-1, triggers protein kinase C-dependent activation of MAPK(erk1/2), leading to the up-regulation of macrophage urokinase type plasminogen activator and matrix metalloproteinase (MMP)-9 expression.	Arginine	39-42	mitogen-activated protein kinase 3	Homo sapiens	154-158
11827968-2	2002	We have reported that alpha1:Ser(2091)-Arg(2108), a peptide derived from the alpha1-chain of laminin-1, triggers protein kinase C-dependent activation of MAPK(erk1/2), leading to the up-regulation of macrophage urokinase type plasminogen activator and matrix metalloproteinase (MMP)-9 expression.	Arginine	39-42	mitogen-activated protein kinase 3	Homo sapiens	159-165
11839732-2	2002	Here we assess the significance of the Arg-95 to Trp gain-of-function mutation in the v-Src SH3 domain through comparisons of Src-/- fibroblasts transformed with either Prague C v-Src or a point mutant (v-Src-RT) containing a normal (Arg-95) SH3 domain.	Arginine	39-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-91
11956086-1	2002	The recent identification of mutations at arginine 482 (R482) in human Breast Cancer Resistance Protein (BCRP) in two drug-selected cell lines largely explains some discrepancies observed in the cross-resistance profiles of human cell lines overexpressing this multidrug transporter.	Arginine	42-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	71-103
11956086-1	2002	The recent identification of mutations at arginine 482 (R482) in human Breast Cancer Resistance Protein (BCRP) in two drug-selected cell lines largely explains some discrepancies observed in the cross-resistance profiles of human cell lines overexpressing this multidrug transporter.	Arginine	42-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	105-109
12182908-8	2002	These findings suggested that the inhibitory effects of ATF on sc-uPA activation by Lys-plasmin and Glu- or Lys-plasminogen activation by tc-uPA were related to the binding of ATF (by its C-terminal Lys(135) and internal Lys/Arg residue) with the kringle 1-4 of plasmin and plasminogen, respectively.	Arginine	225-228	plasminogen activator, urokinase	Homo sapiens	141-144
11932991-4	2002	She was homozygous for the deletion of codon 608 (delR608), which encodes an arginine residue in the Acid Sphingomyelinase gene.	Arginine	77-85	sphingomyelin phosphodiesterase 1	Homo sapiens	101-122
11926824-12	2002	SNAP converted Arg- and H4B-free iNOS dimer into monomer that could not redimerize, but had no effect on iNOS dimer preincubated with Arg and H4B.	Arginine	15-18	nitric oxide synthase 2	Homo sapiens	33-37
11916912-4	2002	Additionally, the insulin secretory response to intravenous arginine at euglycemia was similar in the control and diabetic groups (264 +/- 33.5 and 193 +/- 61.3 pmol/l; P = 0.3).	Arginine	60-68	insulin	Homo sapiens	18-25
11925253-1	2002	There is currently considerable interest in arginine and its structural analogues in the context of nitric oxide synthase (NOS) substrates and inhibitors.	Arginine	44-52	nitric oxide synthase 2	Homo sapiens	100-121
12056782-10	2002	In conjunction with this, non-selective NOS inhibition increased renal protein breakdown, whereas selective iNOS inhibition increased renal arginine production.	Arginine	140-148	nitric oxide synthase 2	Rattus norvegicus	108-112
12059071-5	2002	The PON1 gene has two common coding region polymorphisms, Leu55--&gt;Met and Gln192--&gt;Arg.	Arginine	89-92	paraoxonase 1	Homo sapiens	4-8
12133291-2	2002	METHODS: Human proinsulin cDNA was cloned from its genomic gene and mutated by overlap extension PCR, introducing furin consensus cleavage sequences (Arg-Xaa-Lys/Arg-Arg).	Arginine	150-153	insulin	Homo sapiens	15-25
12133291-2	2002	METHODS: Human proinsulin cDNA was cloned from its genomic gene and mutated by overlap extension PCR, introducing furin consensus cleavage sequences (Arg-Xaa-Lys/Arg-Arg).	Arginine	162-165	insulin	Homo sapiens	15-25
12133291-2	2002	METHODS: Human proinsulin cDNA was cloned from its genomic gene and mutated by overlap extension PCR, introducing furin consensus cleavage sequences (Arg-Xaa-Lys/Arg-Arg).	Arginine	162-165	insulin	Homo sapiens	15-25
11916912-6	2002	Specifically, the first-phase insulin response was lower in diabetic subjects (329.1 +/- 39.6 vs. 91.3 +/- 34.1 pmol/l; P &lt; 0.001), as was the slope of glucose potentiation of the insulin response to arginine (102 +/- 18.7 vs. 30.2 +/- 6.1 pmol/l per mmol/l; P = 0.005) and the maximum insulin response to arginine (2,524 +/- 413 vs. 629 +/- 159 pmol/l; P = 0.001).	Arginine	203-211	insulin	Homo sapiens	30-37
11916912-6	2002	Specifically, the first-phase insulin response was lower in diabetic subjects (329.1 +/- 39.6 vs. 91.3 +/- 34.1 pmol/l; P &lt; 0.001), as was the slope of glucose potentiation of the insulin response to arginine (102 +/- 18.7 vs. 30.2 +/- 6.1 pmol/l per mmol/l; P = 0.005) and the maximum insulin response to arginine (2,524 +/- 413 vs. 629 +/- 159 pmol/l; P = 0.001).	Arginine	309-317	insulin	Homo sapiens	30-37
11985794-0	2002	Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors.	Arginine	87-90	tumor necrosis factor	Mus musculus	0-27
12575193-0	2002	[The paraoxonase Gln-Arg 192 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population].	Arginine	21-24	paraoxonase 1	Homo sapiens	5-16
12575193-8	2002	CONCLUSION: These may be an association of the QQ genotype of the paraoxonase 192 Gln-Arg polymorphism with the decrease of serum apoA I level and the increase of serum apoE level in endogenous hypertriglyceridemica.	Arginine	86-89	paraoxonase 1	Homo sapiens	66-77
12575193-8	2002	CONCLUSION: These may be an association of the QQ genotype of the paraoxonase 192 Gln-Arg polymorphism with the decrease of serum apoA I level and the increase of serum apoE level in endogenous hypertriglyceridemica.	Arginine	86-89	apolipoprotein A1	Homo sapiens	130-136
12575193-8	2002	CONCLUSION: These may be an association of the QQ genotype of the paraoxonase 192 Gln-Arg polymorphism with the decrease of serum apoA I level and the increase of serum apoE level in endogenous hypertriglyceridemica.	Arginine	86-89	apolipoprotein E	Homo sapiens	169-173
12575207-1	2002	OBJECTIVE: A polymorphism at codon 72 of the human tumor-suppressor gene, p53, results in translation to either arginine or proline.	Arginine	112-120	TSC complex subunit 1	Homo sapiens	51-67
12575207-1	2002	OBJECTIVE: A polymorphism at codon 72 of the human tumor-suppressor gene, p53, results in translation to either arginine or proline.	Arginine	112-120	tumor protein p53	Homo sapiens	74-77
12575207-8	2002	CONCLUSION: In this population, individuals homozygous for the arginine variant of codon 72 of the p53 gene were at increased risk of cervical cancer.	Arginine	63-71	tumor protein p53	Homo sapiens	99-102
11792702-2	2002	Insertion of a neo cassette flanked by loxP sites in the third intron of Apoe reduced expression of the Arg-61 allelic variant in hypoE mice and resulted in plasma apoE levels that were approximately 2-5% of normal.	Arginine	104-107	apolipoprotein E	Mus musculus	73-77
12165288-7	2002	Furthermore, since those mRNA inductions by BK were enhanced by nitro-L-arginine-methyl ester (L-NAME) and attenuated by L-arginine (L-Arg), NO was speculated to negatively contribute to the expressions of TF and PAI-1.	Arginine	133-138	serpin family E member 1	Rattus norvegicus	213-218
11788604-0	2002	An N-terminal arginine-rich cluster and a proline-alanine-threonine repeat region determine the cellular localization of the herpes simplex virus type 1 ICP34.5 protein and its ligand, protein phosphatase 1.	Arginine	14-22	neuropeptide Y receptor Y4	Homo sapiens	185-206
11792702-4	2002	Further reduction of apoE expression in hypoE/Apoe(-/-) heterozygous mice led to an increase in remnant lipoprotein-associated cholesterol levels, demonstrating that hypoE mice express close to the threshold level of Arg-61 apoE required for a normal lipoprotein profile.	Arginine	217-220	apolipoprotein E	Mus musculus	21-25
11866428-3	2002	Substitution of these lysines by arginine resulted in cell-surface expression of OST48, whereas ER residency was maintained when either Lys-5 or Lys-3 but not both was replaced with arginine.	Arginine	33-41	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	81-86
11790767-8	2002	In contrast, peptides based on the JBDs of ATF2 and c-Jun inhibited JNK activity by &lt;40%, which agreed with their lack of homology to the critical Arg-156 and Pro-157.	Arginine	150-153	mitogen-activated protein kinase 8	Homo sapiens	68-71
11899188-10	2002	The cardiac index averaged 2.7+/-0.8 L x min(-1) x m(-2) in control patients and 2.9+/-0.7 L x min(-1) x m(-2) in arginine patients immediately after surgery (p = 0.09).	Arginine	114-122	CD59 molecule (CD59 blood group)	Homo sapiens	95-101
11867343-7	2002	We conclude that the increase in NO production in silica-exposed lungs was associated with increased L-arg uptake from the vasculature, presumably resulting from increased CAT-1 and CAT-2, and by increased L-arg metabolism via arginase.	Arginine	101-106	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	172-177
11856771-3	2002	During a survey of risk factors for renal and cardiovascular disease in one such community, an association between a common polymorphism at codon 72 (Arg/Pro) of the p53 gene and markers of renal disease was sought.	Arginine	150-153	tumor protein p53	Homo sapiens	166-169
11836426-2	2002	The DNA binding domain of EBNA1 is required for all three function, and a Gly-Arg-rich sequence between amino acids 325 and 376 is required for both the transcriptional activation and partitioning functions.	Arginine	78-81	EBNA-1	Human gammaherpesvirus 4	26-31
11889183-5	2002	The acute insulin response to arginine was lower in GADab+ than in GADab- thyroiditis subjects at glucose concentration of 14 and &gt;25 mmol/liter (AIR(14): 76.8 +/- 52.0 vs. 158.2 +/- 118.2 mU/liter, P = 0.040; AIR(&gt;25): 84.3 +/- 64.4 vs. 167.9 +/- 101.5 mU/liter, P = 0.035).	Arginine	30-38	insulin	Homo sapiens	10-17
11986889-5	2002	These effects are reversed, or at least reduced, by lipid-lowering agents and (because LDL cholesterol down-regulates endothelial nitric oxide synthase) by the administration of L-arginine, the substrate for nitric oxide (NO) formation.	Arginine	178-188	nitric oxide synthase 3	Homo sapiens	118-151
11986911-5	2002	Both oral glucose and L-arginine induced greater increases in plasma insulin in obese hypertensives than in lean normotensives.	Arginine	22-32	insulin	Homo sapiens	69-76
11986911-6	2002	Endothelial dysfunction which accompanies the insulin resistant state of obesity, glucose intolerance and hypertension, may account for the different BP effects induced by glucose and L-arginine in obese hypertensives and lean normotensives.	Arginine	184-194	insulin	Homo sapiens	46-53
11884127-7	2002	This structure suggests that upon thrombin binding, the scissile peptide bond of the intact peptide and the Ser195 O(gamma) are separated from each other, impairing the nucleophilic attack of the Ser195 O(gamma) toward the N(alpha)(Me)Arg carbonyl group.	Arginine	235-238	coagulation factor II, thrombin	Homo sapiens	34-42
11714724-11	2002	In the fungal alpha1,2-mannosidase this arginine is replaced by glycine.	Arginine	40-48	mannosidase alpha class 1A member 2	Homo sapiens	14-34
11849436-6	2002	iNOS activity was assessed by calculating conversion of l-arginine to l-citrulline.	Arginine	56-66	nitric oxide synthase 2	Rattus norvegicus	0-4
11897155-6	2002	The resulting PTH1R/[Arg(11)]PTH(1-11) complex has the N-terminus of PTH interacting with residues of the third extracellular loop of PTH1R, as a possible mode for receptor activation.	Arginine	21-24	parathyroid hormone 1 receptor	Homo sapiens	14-19
11897155-6	2002	The resulting PTH1R/[Arg(11)]PTH(1-11) complex has the N-terminus of PTH interacting with residues of the third extracellular loop of PTH1R, as a possible mode for receptor activation.	Arginine	21-24	parathyroid hormone	Homo sapiens	14-17
11897155-6	2002	The resulting PTH1R/[Arg(11)]PTH(1-11) complex has the N-terminus of PTH interacting with residues of the third extracellular loop of PTH1R, as a possible mode for receptor activation.	Arginine	21-24	parathyroid hormone	Homo sapiens	29-32
11897155-6	2002	The resulting PTH1R/[Arg(11)]PTH(1-11) complex has the N-terminus of PTH interacting with residues of the third extracellular loop of PTH1R, as a possible mode for receptor activation.	Arginine	21-24	parathyroid hormone 1 receptor	Homo sapiens	134-139
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Arginine	56-59	parathyroid hormone	Homo sapiens	64-67
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Arginine	56-59	parathyroid hormone	Homo sapiens	89-92
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Arginine	140-143	parathyroid hormone	Homo sapiens	64-67
11849441-1	2002	l-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	69-90
11849445-8	2002	Sequence analysis of lysozyme exon 2 from the affected individuals revealed a nucleotide substitution predicting a substitution of the amino acid at position 64 in the mature protein from tryptophane, an aromatic residue to the cationic residue arginine (W64R).	Arginine	245-253	lysozyme	Homo sapiens	21-29
11854119-5	2002	Concentrations of TNF-alpha and IL-6 were related (P&lt;0.01) to visceral obesity, as well as to adhesin levels and responses to L-arginine.	Arginine	129-139	tumor necrosis factor	Homo sapiens	18-27
11854119-5	2002	Concentrations of TNF-alpha and IL-6 were related (P&lt;0.01) to visceral obesity, as well as to adhesin levels and responses to L-arginine.	Arginine	129-139	interleukin 6	Homo sapiens	32-36
11897155-8	2002	We postulate that the improved signaling properties of [Arg(11)]PTH(1-11) over wild type PTH(1-11) is due to a stable hydrogen bond between Arg(11) and E444, at the beginning of TM7.	Arginine	140-143	parathyroid hormone	Homo sapiens	89-92
11815461-4	2002	At submaximal levels of beta-cell fuel secretagogue, arginine (which promotes calcium entry) or glucagon (which activates PKA) produces a small first-phase insulin response but minimal or no second-phase response; carbachol (which activates PKC and promotes calcium entry) generates biphasic insulin response in the presence of minimal fuel (3.3 mmol/l glucose).	Arginine	53-61	insulin	Homo sapiens	156-163
11827515-3	2002	Recent analysis of a cocrystal of the BoNT/B LC and its substrate synaptobrevin 2 suggested that Arg(362) and Tyr(365) of the homologous BoNT/A may be directly involved in catalysis.	Arginine	97-100	vesicle associated membrane protein 2	Homo sapiens	66-81
11827520-0	2002	Characterization of the tertiary structure of soluble CD4 bound to glycosylated full-length HIVgp120 by chemical modification of arginine residues and mass spectrometric analysis.	Arginine	129-137	CD4 molecule	Homo sapiens	54-57
11827520-2	2002	We have examined structural features of recombinant soluble CD4 (sCD4) by chemical modification of arginine residues with hydroxyphenylglyoxal and subsequent analysis by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry.	Arginine	99-107	CD4 molecule	Homo sapiens	60-63
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	23-26	membrane metalloendopeptidase	Homo sapiens	75-85
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	23-26	membrane metalloendopeptidase	Homo sapiens	140-150
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	63-66	membrane metalloendopeptidase	Homo sapiens	75-85
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	63-66	membrane metalloendopeptidase	Homo sapiens	140-150
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Arginine	63-71	tumor protein p53	Homo sapiens	25-28
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Arginine	63-71	tumor protein p53	Homo sapiens	124-127
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Arginine	73-76	tumor protein p53	Homo sapiens	25-28
11807792-3	2002	A common polymorphism of p53, encoding either proline (Pro) or arginine (Arg) at position 72, affects the susceptibility of p53 to E6 mediated degradation in vivo.	Arginine	73-76	tumor protein p53	Homo sapiens	124-127
11807792-8	2002	Our results also indicate that the p53 codon 72 genotype frequencies in Indian Oral Cancer patients are 0.55 (Arg) and 0.45 (Pro) as per Hardy-Weinberg equilibrium.	Arginine	110-113	tumor protein p53	Homo sapiens	35-38
11845867-11	2002	CONCLUSIONS: [1-Deaminopenicillamine, 4-valine, 8-D-arginine] vasopressin may provide specific antispastic effect in either prophylaxis or treatment of the AVP-related vasospasm in the internal mammary artery.	Arginine	51-60	arginine vasopressin	Homo sapiens	62-73
11845867-11	2002	CONCLUSIONS: [1-Deaminopenicillamine, 4-valine, 8-D-arginine] vasopressin may provide specific antispastic effect in either prophylaxis or treatment of the AVP-related vasospasm in the internal mammary artery.	Arginine	51-60	arginine vasopressin	Homo sapiens	156-159
11815481-6	2002	Finally, surrogate insulin sensitivity measures quantified from OGTT and the glucose-dependent arginine-stimulation test only weakly correlated to M/I(clamp) (R(2) approx equal to 0.25).	Arginine	95-103	insulin	Homo sapiens	19-26
11815485-3	2002	Proinsulin conversion to insulin was assessed using proinsulin/insulin (PI/I) ratios immediately after an acute stimulus (OGTT, 30 min; hyperglycemic clamp, 2.5-5.0 min after glucose and arginine).	Arginine	187-195	insulin	Homo sapiens	0-10
11815461-4	2002	At submaximal levels of beta-cell fuel secretagogue, arginine (which promotes calcium entry) or glucagon (which activates PKA) produces a small first-phase insulin response but minimal or no second-phase response; carbachol (which activates PKC and promotes calcium entry) generates biphasic insulin response in the presence of minimal fuel (3.3 mmol/l glucose).	Arginine	53-61	insulin	Homo sapiens	292-299
11815461-5	2002	Glucagon produces full biphasic response in the presence of 10.0 mmol/l glucose, whereas arginine requires near-maximal stimulatory glucose (16.7 mmol) to produce full biphasic insulin response.	Arginine	89-97	insulin	Homo sapiens	177-184
11815471-6	2002	This inhibition was also evident when insulin release rates were corrected for the respective increments (absolute or percentage) in plasma glucose levels and was not due to beta-cell exhaustion because the arginine bolus still elicited a large peak of insulin secretion (4,790 +/- 2,330 pmol.min(-1).m(-2)).	Arginine	207-215	insulin	Homo sapiens	253-260
11815472-2	2002	Insulin secretion was then assessed in response to glucose (16.7 mmol/l), arginine (20 mmol/l), and glyburide (200 micromol/l) during static incubation or by perifusion.	Arginine	74-82	insulin	Homo sapiens	0-7
11834428-0	2002	The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH release in normal subjects.	Arginine	31-39	growth hormone releasing hormone	Homo sapiens	23-27
11796519-7	2002	17beta-E2 suppressed the partial stimulation of tartrate-resistant acid phosphatase-positive multinucleated osteoclast-like cell formation induced by [Arg(2)]human (h) PTH-(1-34) (10(-7) M) or hPTH-(3-34) (10(-7) M), but not that caused by 10(-7) M hPTH-(53-84).	Arginine	151-154	parathyroid hormone	Rattus norvegicus	168-171
11834428-1	2002	OBJECTIVE: The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH secretion was studied in man using a GHRH antagonist (GHRH-Ant).	Arginine	42-50	growth hormone releasing hormone	Homo sapiens	34-38
11834428-4	2002	RESULTS: The combined administration of GHRH-Ant distinctly inhibited the arginine- and insulin-induced GH release.	Arginine	74-82	growth hormone releasing hormone	Homo sapiens	40-44
11834428-6	2002	These responses to arginine and insulin were also completely inhibited by the combined administration of GHRH-Ant.	Arginine	19-27	growth hormone releasing hormone	Homo sapiens	105-109
11843620-1	2002	The secondary structure of a bradykinin B(1)receptor antagonist B-10324 (F5C-Lys-(1)- Lys(0)-Arg(1)-Pro(2)- Hyp(3)-Gly(4)-CpG(5)- Ser(6)-DTic(7)-CpG(8)) was determined by NMR at 800MHz.	Arginine	93-96	bradykinin receptor B1	Homo sapiens	29-52
11724789-4	2002	Expressed as a glutathione S-transferase fusion protein, PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N(G)-monomethylarginine and asymmetric omega-N(G),N(G)-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrate in a processive manner with a specific activity of 144 pmol methyl groups transferred min(-1) mg(-1) enzyme.	Arginine	143-151	protein arginine methyltransferase 6	Homo sapiens	57-62
11791011-4	2002	The apoptosis inhibited by bradykinin was reduced by nitric oxide inhibitor N(G)-monomethyl-L-arginine (L-NMMA) and consequently restored by combined treatment with L-NMMA and L-arginine.	Arginine	92-102	kininogen 1	Homo sapiens	27-37
11791011-6	2002	Bradykinin increased nitric oxide production, which was inhibited by L-NMMA and restored by combined treatment with L-NMMA and L-arginine.	Arginine	127-137	kininogen 1	Homo sapiens	0-10
11849379-0	2002	L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA.	Arginine	0-10	erythropoietin	Homo sapiens	29-43
11834450-8	2002	We postulate that an arginine-glycine-aspartic acid sequence found on rat and mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Arginine	21-29	growth hormone receptor	Mus musculus	84-88
11834450-8	2002	We postulate that an arginine-glycine-aspartic acid sequence found on rat and mouse GHBP but absent in other species is responsible for the association of GHBP with the plasma membrane by binding to one or more integrins on the surface of liver cells.	Arginine	21-29	growth hormone receptor	Mus musculus	155-159
11833049-6	2002	The patient"s DNA sequence exhibited a C to G substitution in exon 3 of the apoE gene at the position of the 25th amino acid, resulting in an amino acid substitution of the arginine residue for cysteine residue.	Arginine	173-181	apolipoprotein E	Homo sapiens	76-80
11833049-10	2002	These findings are consistent with the idea that an increase in binding of triglyceride-rich lipoproteins possessing apoE (Arg(25)--&gt;Cys) to endothelial cells may promote deposition of lipid in the glomerular capillaries.	Arginine	123-126	apolipoprotein E	Homo sapiens	117-121
11849379-2	2002	In the present study, we examined the effect of L-arginine on Epo gene expression in Hep3B cells and BDF1 mice.	Arginine	48-58	erythropoietin	Homo sapiens	62-65
11849379-5	2002	RESULTS: Incubation with L-NMMA under hypoxic conditions inhibited Epo expression, but this inhibition was recovered by the addition of L-arginine.	Arginine	136-146	erythropoietin	Homo sapiens	67-70
11849379-13	2002	CONCLUSION: L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with NG-monomethyl-L-arginine.	Arginine	12-22	erythropoietin	Homo sapiens	41-55
11829529-6	2002	Transfection with pcDNA-AII increased AII expression and activity but had little effect on nitrite production even if no l-arginine was added.	Arginine	121-131	NLR family pyrin domain containing 3	Homo sapiens	18-27
11829529-6	2002	Transfection with pcDNA-AII increased AII expression and activity but had little effect on nitrite production even if no l-arginine was added.	Arginine	121-131	NLR family pyrin domain containing 3	Homo sapiens	24-27
11790850-6	2002	Moreover, unlike the catalytically equivalent arginine fingers of the eukaryotic GAPs, which are invariably contained within flexible loops, the critical arginine in YopE(GAP) (Arg144) is part of an alpha-helix.	Arginine	154-162	targeted effector	Yersinia pestis	166-175
11929601-6	2002	The ubiquitin independence of Ste3p ligand-dependent uptake was further indicated by analysis of receptor mutants having Lys-to-Arg substitutions at all possible ubiquitin acceptor sites.	Arginine	128-131	Ste3p	Saccharomyces cerevisiae S288C	30-35
11858488-7	2002	The structural modeling of thrombin Perija suggests that Ala-548 is located close to the limb of the cavity wall of the substrate binding pocket, and that the methyl group blocks protrusion of the guanidino group of Arg into the cavity.	Arginine	216-219	coagulation factor II, thrombin	Homo sapiens	27-35
11802729-10	2002	Moreover, human neutrophils used the myeloperoxidase-H(2)O(2) system to generate sulfinamides in model peptides containing lysine or arginine residues.	Arginine	133-141	myeloperoxidase	Homo sapiens	37-52
11836677-4	2002	Subjects homozygous for the p53 Pro allele had a more than 2-fold increased risk of developing ESCC (OR=2.18; 95%CI=1.10-4.35, adjusted for age, sex, and smoking), whereas the Arg/Pro genotype was not associated with elevated risk of the cancer (adjusted OR=0.84; 95%CI=0.42-1.68).	Arginine	176-179	tumor protein p53	Homo sapiens	28-31
11796200-3	2002	Whereas the Km of eNOS for L-arginine was 2 microM in cell extracts, the L-arginine concentration of half-maximal eNOS stimulation was increased to 29 microM in intact cells.	Arginine	27-37	nitric oxide synthase 3	Bos taurus	18-22
11802720-10	2002	After TAFIa was converted to TAFIai, it was more susceptible to proteolytic degradation by thrombin, which cleaved TAFIai at Arg(302).	Arginine	125-128	coagulation factor II, thrombin	Homo sapiens	91-99
11706008-10	2002	Alanine mutations of membrane-proximal basic amino acid residues in the cytoplasmic domain of L-selectin identified arginine 357 as a critical residue for both ezrin and moesin interaction.	Arginine	116-124	moesin	Homo sapiens	170-176
11785951-2	2002	Based on the sequence homology between rabbit muscle PFK and two bacterial PFKs and the crystal structures of the latter, Ser(530), Arg(292) and His(662) of the rabbit enzyme are implicated as binding sites for Fru-2,6-P(2).	Arginine	132-135	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	53-56
11796200-3	2002	Whereas the Km of eNOS for L-arginine was 2 microM in cell extracts, the L-arginine concentration of half-maximal eNOS stimulation was increased to 29 microM in intact cells.	Arginine	73-83	nitric oxide synthase 3	Bos taurus	114-118
11796200-5	2002	The effects of inhibitors of endothelial nitric oxide synthesis also suggested that extracellular L-arginine availability limits intracellular eNOS activity.	Arginine	98-108	nitric oxide synthase 3	Bos taurus	143-147
11796200-6	2002	Treatment of intact cells with the calcium ionophore A23187 reduced the L-arginine concentration of half-maximal eNOS activity, which is consistent with a measured increase in L-arginine uptake.	Arginine	72-82	nitric oxide synthase 3	Bos taurus	113-117
11796200-6	2002	Treatment of intact cells with the calcium ionophore A23187 reduced the L-arginine concentration of half-maximal eNOS activity, which is consistent with a measured increase in L-arginine uptake.	Arginine	176-186	nitric oxide synthase 3	Bos taurus	113-117
11796200-7	2002	Increases in eNOS activity induced by several agents were closely correlated with enhanced L-arginine uptake into cells (r = 0.89).	Arginine	91-101	nitric oxide synthase 3	Bos taurus	13-17
11796200-8	2002	The "arginine paradox" may be explained in part by regulated L-arginine uptake into a compartment, probably represented by caveolae, that contains eNOS and that is distinct from the bulk cytosolic L-arginine.	Arginine	5-13	nitric oxide synthase 3	Bos taurus	147-151
11796200-8	2002	The "arginine paradox" may be explained in part by regulated L-arginine uptake into a compartment, probably represented by caveolae, that contains eNOS and that is distinct from the bulk cytosolic L-arginine.	Arginine	61-71	nitric oxide synthase 3	Bos taurus	147-151
11786524-8	2002	The high iNOS activity was associated with reduced cardiac L-arginine in TG hearts to only 15% of the WT, indicating limited substrate availability, whereas L-citrulline was 20-fold elevated.	Arginine	59-69	nitric oxide synthase 2, inducible	Mus musculus	9-13
11777982-4	2002	In this study, we demonstrate that stimulation of murine peritoneal macrophages with MSP results in the RON-dependent up-regulation of arginase, an enzyme associated with alternative activation that competes with iNOS for the substrate L-arginine, the products of which are involved in cell proliferation and matrix synthesis.	Arginine	236-246	nitric oxide synthase 2, inducible	Mus musculus	213-217
11814687-14	2002	A notable single nucleotide polymorphism in the coding region (cSNP) with an amino acid substitution of glycine (GGG) to arginine (AGG) was found at codon 335 of the REIC gene.	Arginine	121-129	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	166-170
11727199-1	2002	C--&gt;U RNA editing of neurofibromatosis 1 (NF1) mRNA changes an arginine (CGA) to a UGA translational stop codon, predicted to result in translational termination of the edited mRNA.	Arginine	66-74	neurofibromin 1	Homo sapiens	24-43
11689556-8	2002	The results are consistent with a mechanism whereby inhibitors bind to a heme-containing iNOS monomer species to form an inactive iNOS monomer-heme-inhibitor complex in a pterin- and l-arginine-independent manner.	Arginine	183-193	nitric oxide synthase 2	Homo sapiens	89-93
11689556-8	2002	The results are consistent with a mechanism whereby inhibitors bind to a heme-containing iNOS monomer species to form an inactive iNOS monomer-heme-inhibitor complex in a pterin- and l-arginine-independent manner.	Arginine	183-193	nitric oxide synthase 2	Homo sapiens	130-134
11727199-1	2002	C--&gt;U RNA editing of neurofibromatosis 1 (NF1) mRNA changes an arginine (CGA) to a UGA translational stop codon, predicted to result in translational termination of the edited mRNA.	Arginine	66-74	neurofibromin 1	Homo sapiens	45-48
11814282-1	2002	BACKGROUND: Arginine is an agent commonly used to evaluate adequacy of growth hormone (GH) secretion.	Arginine	12-20	growth hormone 1	Homo sapiens	71-85
12025873-2	2002	Arginine led to significant increases in PMN arginine, ornithine, citrulline, aspartate, glutamate and alanine concentrations as well as increased H2O2-generation and MPO activity while O(2-)-formation was decreased.	Arginine	0-8	myeloperoxidase	Homo sapiens	167-170
11742806-0	2002	Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).	Arginine	8-16	tumor necrosis factor	Homo sapiens	55-64
11742806-4	2002	Tumor necrosis factor-alpha (TNF-alpha) and bacterial lipopolysaccharide induce a transient stimulation of arginine influx and efflux through system y(+).	Arginine	107-115	tumor necrosis factor	Homo sapiens	0-27
11742806-4	2002	Tumor necrosis factor-alpha (TNF-alpha) and bacterial lipopolysaccharide induce a transient stimulation of arginine influx and efflux through system y(+).	Arginine	107-115	tumor necrosis factor	Homo sapiens	29-38
11742806-9	2002	It is concluded that modulation of endothelial arginine transport by TNF-alpha or lipopolysaccharide occurs exclusively through changes in CAT2B and CAT1 expression and is dissociated from stimulation of nitric oxide production.	Arginine	47-55	tumor necrosis factor	Homo sapiens	69-78
11908643-0	2002	Towards a structure-function analysis of bovine lactoferricin and related tryptophan- and arginine-containing peptides.	Arginine	90-98	lactotransferrin	Homo sapiens	48-61
12055338-1	2002	Nitric oxide (NO) is synthesized from L-arginine by NO synthase (NOS).	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	52-63
12017288-0	2002	Stimulation of arginine consumption and asparagine production in LPS-activated macrophages.	Arginine	15-23	toll-like receptor 4	Mus musculus	65-68
12017288-4	2002	When Raw264.7 cells were incubated with 10 or 100 ng/mL LPS, the consumption of arginine and the production of citrulline, nitric oxide (NO) and asparagine were significantly increased.	Arginine	80-88	toll-like receptor 4	Mus musculus	56-59
11908643-8	2002	Residues that are of particular importance for the activity of lactoferricin are tryptophan and arginine.	Arginine	96-104	lactotransferrin	Homo sapiens	63-76
11908643-10	2002	While the antimicrobial, antifungal, antitumour, and antiviral properties of lactoferricin can be related to the Trp/Arg-rich portion of the peptide, we suggest that the anti-inflammatory and immunomodulating properties are more related to a positively charged region of the molecule, which, like the alpha- and beta-defensins, may act as a chemokine.	Arginine	117-120	lactotransferrin	Homo sapiens	77-90
12000182-1	2002	Nitric oxide (NO), a labile free radical synthesised from L-arginine by the action of nitric oxide synthase (NOS), is said to be implicated in uraemic complications, such as infection and a tendency to bleed.	Arginine	58-68	nitric oxide synthase 2	Homo sapiens	86-107
11906459-2	2002	We have shown that exogenously administered L-arginine protects against water immersion restraint (WIR) stress-induced gastric mucosal lesions in rats through preservation of nitric oxide (NO) generation via constitutive nitric oxide synthase (cNOS), but not inducible nitric oxide synthase (iNOS), in the gastric mucosa.	Arginine	44-54	nitric oxide synthase 2	Rattus norvegicus	259-290
27786090-1	2002	Nitric oxide (NO), a labile free radical synthesised from L-arginine by the action of nitric oxide synthase (NOS), is said to be implicated in uraemic complications, such as infection and a tendency to bleed.	Arginine	58-68	nitric oxide synthase 2	Homo sapiens	86-107
11782367-7	2002	Transient expression of dominant-negative p53 ((175)Arg--&gt;His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels.	Arginine	52-55	tumor protein p53	Homo sapiens	42-45
11906459-2	2002	We have shown that exogenously administered L-arginine protects against water immersion restraint (WIR) stress-induced gastric mucosal lesions in rats through preservation of nitric oxide (NO) generation via constitutive nitric oxide synthase (cNOS), but not inducible nitric oxide synthase (iNOS), in the gastric mucosa.	Arginine	44-54	nitric oxide synthase 2	Rattus norvegicus	292-296
11906459-11	2002	Pretreatment with L-arginine, but not D-arginine, attenuated decreases in hexosamine and adherent mucus concentrations and cNOS activity and increases in total NOS and iNOS activities and nitrite/nitrate concentration in the gastric mucosal tissue of rats subjected to WIR stress for 3 and 6 h in a dose-dependent manner.	Arginine	18-28	nitric oxide synthase 2	Rattus norvegicus	168-172
12438709-8	2002	A very rare polymorphism resulting in a conserved amino acid change Lys to Arg was found in PSCD2.	Arginine	75-78	cytohesin 2	Homo sapiens	92-97
11812265-2	2002	The major cause of the endothelial dysfunction is decreased bioavailability of nitric oxide (NO), a potent biological vasodilator produced in vascular endothelium from L-arginine by the endothelial NO synthase (eNOS).	Arginine	168-178	nitric oxide synthase 3	Homo sapiens	211-215
15618661-1	2002	Expression and functional evaluation of ABCG2 (Arg 482)*.	Arginine	47-50	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	40-45
15618661-6	2002	Sequence analysis has revealed that the cloned ABCG2 has an arginine at the amino acid position 482, as does the wild type.	Arginine	60-68	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-52
11867902-13	2002	Moreover, IL-10 levels were significantly increased in the wound fluid in hemorrhaged animals receiving L-arginine compared to vehicle-treated mice.	Arginine	104-114	interleukin 10	Mus musculus	10-15
11867902-12	2002	In contrast, in vivo the increased IL-6 release at the wound site was decreased in L-arginine-treated mice following hemorrhage.	Arginine	83-93	interleukin 6	Mus musculus	35-39
11779589-6	2002	MAIN OUTCOME MEASURE(S): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity).	Arginine	98-106	tumor protein p53	Homo sapiens	70-73
11779589-11	2002	p53 arginine homozygotes have lower risk for endometriosis.	Arginine	4-12	tumor protein p53	Homo sapiens	0-3
11799072-5	2002	Blocking the generation of NO by 3 different L-arginine analogues increased protein synthesis by an average of 75% in the aorta, in association with enhanced ERK 1/2 phosphorylation.	Arginine	45-55	mitogen-activated protein kinase 3	Homo sapiens	158-165
12125280-1	2002	Effects of an antagonist of AT-1 receptors for angiotensin-II (Ang-II) irbezantane on the NO-synthase and arginase ways of the metabolism of L-arginine were studied in plasma and erythrocytes of the patients with arterial hypertension.	Arginine	141-151	angiotensinogen	Homo sapiens	47-61
12125280-1	2002	Effects of an antagonist of AT-1 receptors for angiotensin-II (Ang-II) irbezantane on the NO-synthase and arginase ways of the metabolism of L-arginine were studied in plasma and erythrocytes of the patients with arterial hypertension.	Arginine	141-151	angiotensinogen	Homo sapiens	63-69
12125280-3	2002	Inhibiting AT-1 receptors for Ang-II with high-affinity antagonist irbezantane normalized the ratio between two alternative ways of L-arginine metabolism through inhibiting the arginase way and reciprocal activating the NO-synthase way both in human plasma and erythrocytes.	Arginine	132-142	angiotensinogen	Homo sapiens	30-36
11799072-6	2002	PD98059 significantly reduced L-arginine analogue-induced protein synthesis and ERK 1/2 phosphorylation, confirming the involvement of ERK 1/2 as an important signaling element.	Arginine	30-40	mitogen-activated protein kinase 3	Homo sapiens	80-87
11799072-6	2002	PD98059 significantly reduced L-arginine analogue-induced protein synthesis and ERK 1/2 phosphorylation, confirming the involvement of ERK 1/2 as an important signaling element.	Arginine	30-40	mitogen-activated protein kinase 3	Homo sapiens	135-142
11755782-6	2002	We have demonstrated an overexpression of utrophin, visualised by immunofluorescence and quantified by Western blotting, in normal myotubes and in mdx (the animal model of DMD) myotubes, as in normal (C57) and mdx mice, both treated with nitric oxide (NO) donor or L-arginine, the NOS substrate.	Arginine	265-275	utrophin	Mus musculus	42-50
16233323-6	2002	In contrast, the survival rate of the wild-type and the put1-disruptant strains was found to increase after freezing in proportion to their arginine contents.	Arginine	140-148	proline dehydrogenase	Saccharomyces cerevisiae S288C	56-60
11752097-0	2002	[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.	Arginine	1-4	prepronociceptin	Homo sapiens	17-27
11752097-0	2002	[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.	Arginine	1-4	prepronociceptin	Homo sapiens	60-70
11752097-0	2002	[Arg(14),Lys(15)]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies.	Arginine	1-4	prepronociceptin	Homo sapiens	71-82
12112002-5	2002	L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.	Arginine	0-10	interferon gamma	Homo sapiens	137-146
11862322-7	2002	Interestingly, using the OGTT index, insulin sensitivity was significantly greater in X/Ala (PPARgamma2) + X/Arg (IRS-1) than in Pro/Pro (PPARgamma2) + X/Arg (IRS-1).	Arginine	109-112	insulin	Homo sapiens	37-44
11862322-7	2002	Interestingly, using the OGTT index, insulin sensitivity was significantly greater in X/Ala (PPARgamma2) + X/Arg (IRS-1) than in Pro/Pro (PPARgamma2) + X/Arg (IRS-1).	Arginine	154-157	insulin	Homo sapiens	37-44
11752097-1	2002	The nociceptin (NC)/orphanin FQ analog, [Arg(14),Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP(4)).	Arginine	41-44	prepronociceptin	Homo sapiens	4-14
11752097-1	2002	The nociceptin (NC)/orphanin FQ analog, [Arg(14),Lys(15)]NC, has been recently demonstrated to behave as a potent agonist at the human recombinant NC receptors (OP(4)).	Arginine	41-44	prepronociceptin	Homo sapiens	20-31
11855667-3	2002	NO is synthesized from L-arginine by NO synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	37-48
11862757-2	2002	The arginine paradox refers to the phenomenon that exogenous L-arginine causes NO-mediated biological effects despite the fact that nitric oxide synthases (NOS) are theoretically saturated with the substrate L-arginine.	Arginine	4-12	nitric oxide synthase 2	Homo sapiens	132-154
11939578-1	2002	We have shown that this enzyme can remove terminal arginine from the C5a octapeptide much more efficiently than the classical anaphylatoxin inactivator, carboxypeptidase N (CPN).	Arginine	51-59	complement C5a receptor 1	Homo sapiens	69-72
12008933-2	2002	Since removal of the C-terminal arginine abrogates the anaphylatoxin activity of C3a and C5a, CPR and CPN are regarded as anaphylatoxin inactivators.	Arginine	32-40	complement C5a receptor 1	Homo sapiens	89-92
12008933-2	2002	Since removal of the C-terminal arginine abrogates the anaphylatoxin activity of C3a and C5a, CPR and CPN are regarded as anaphylatoxin inactivators.	Arginine	32-40	cytochrome p450 oxidoreductase	Homo sapiens	94-97
11942570-1	2002	Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.	Arginine	32-35	GNAS complex locus	Homo sapiens	11-19
11942570-3	2002	Activating missense mutations at the Arg 201 codon of the Gs alpha gene ultimately leading to increased levels of cyclic adenosine monophosphate have been implicated in McCune-Albright syndrome and sporadic fibrous dysplasia of bone.	Arginine	37-40	GNAS complex locus	Homo sapiens	58-66
12068494-9	2002	(GGGCCC) in codon 176 inducing the insertion of two amino acid residues (Arg-Ala) in POMC and nonsense mutation (G-7316-T) in codon 180 of gamma-LTH coding region of the same DNA chain were identified in 4 women (5.8%) out of 69 patients with morbid obesity (BMI 40-53 kg/m2).	Arginine	73-76	proopiomelanocortin	Homo sapiens	85-89
11590164-3	2001	Here we targeted the (6R)-5,6,7,8-tetrahydro-l-biopterin (H(4)Bip)-binding site of NOS, which, upon cofactor binding, maximally increases enzyme activity and NO production from substrate l-arginine.	Arginine	187-197	heat shock protein family A (Hsp70) member 5	Homo sapiens	62-65
11983027-10	2001	The supposedly anti-apoptotic homozygous Arg 72-p53 genotype may increase susceptibility of some cancers.	Arginine	41-44	tumor protein p53	Homo sapiens	48-51
12216328-6	2002	Treatment of IRS in regard to endothelial function should be focused initially on lifestyle improvement, such as stopping smoking and eating a balanced diet containing antioxidant vitamins, folic-acid, L-arginine and long-chain omega-3 unsaturated FA.	Arginine	202-212	isoleucyl-tRNA synthetase 1	Homo sapiens	13-16
11714509-1	2001	Measuring nitric-oxide synthase (NOS) activity by monitoring the conversion of L-arginine to L-citrulline is currently the standard assay for NOS activity.	Arginine	79-89	nitric oxide synthase 2	Homo sapiens	10-31
11797051-0	2001	A genetic screen for suppressors of Escherichia coli Tat signal peptide mutations establishes a critical role for the second arginine within the twin-arginine motif.	Arginine	125-133	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	53-56
11797051-0	2001	A genetic screen for suppressors of Escherichia coli Tat signal peptide mutations establishes a critical role for the second arginine within the twin-arginine motif.	Arginine	150-158	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	53-56
11797051-1	2001	The Escherichia coli Tat protein export pathway transports folded proteins synthesized with N-terminal twin-arginine signal peptides.	Arginine	108-116	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	21-24
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Arginine	58-61	thrombospondin 1	Homo sapiens	40-56
11812024-1	2001	Nitric oxide (NO) is synthesized via the oxidation of arginine by a family of nitric oxide synthases (NOS), which are either constitutive (ie.	Arginine	54-62	nitric oxide synthase 2	Homo sapiens	78-100
11746209-1	2001	There has been little evidence to indicate that arginine is the natural substrate for generating nitric oxide synthase (NOS) activity.	Arginine	48-56	nitric oxide synthase 2	Homo sapiens	97-118
11895217-10	2001	The blunting effect of digoxin on the GHRH-induced GH response is counteracted by arginine.	Arginine	82-90	growth hormone releasing hormone	Homo sapiens	38-42
11724556-5	2001	In carboxypeptidase A (EC 3.4.17.1, CPA), the exopeptidase specificity is conferred by an arginine residue (Arg-145) and an asparagine residue (Asn-144).	Arginine	90-98	carboxypeptidase A1	Homo sapiens	36-39
11724556-5	2001	In carboxypeptidase A (EC 3.4.17.1, CPA), the exopeptidase specificity is conferred by an arginine residue (Arg-145) and an asparagine residue (Asn-144).	Arginine	108-111	carboxypeptidase A1	Homo sapiens	36-39
11811522-4	2001	Because methylated arginines can inhibit nitric oxide synthase (NOS) and elevations are reported in several diseases, we explored whether RBCs express this enzyme.	Arginine	19-28	nitric oxide synthase 2	Homo sapiens	41-62
11859928-1	2001	The conserved residues Y239 and L240 of human VPAC1 receptor are predicted to be at the same location as the asparagine and arginine in the "DRY" motif in the Rhodopsin family of G protein-coupled receptors.	Arginine	124-132	vasoactive intestinal peptide receptor 1	Homo sapiens	46-60
12528568-6	2001	Serum GH response to insulin-induced hypoglycemia or arginine stimulation tests was blunted.	Arginine	53-61	growth hormone 1	Homo sapiens	6-8
11744416-6	2001	The inhibitory effect of N(G)-nitro-L-arginine methylester (0.1 mmol/liter) on bradykinin-induced relaxation was lower in UWS- than KHS-incubated segments after U46619 pre-contraction, but similar after KCl pre-contraction; however, the inhibitory effect of 0.5 mmol/liter ouabain was unaffected.	Arginine	36-46	kininogen 1	Homo sapiens	79-89
11859928-1	2001	The conserved residues Y239 and L240 of human VPAC1 receptor are predicted to be at the same location as the asparagine and arginine in the "DRY" motif in the Rhodopsin family of G protein-coupled receptors.	Arginine	124-132	rhodopsin	Homo sapiens	159-168
11714881-7	2001	L-NOARG (100 microM) caused an inhibition of VIP-induced relaxation that was reversed by L-arginine (1 mM) but not by D-arginine (1 mM).	Arginine	89-99	vasoactive intestinal polypeptide	Mus musculus	45-48
11714866-9	2001	After arginine was administered, there was marked improvement in the pathological changes accompanied by decreased levels of endotoxin, lipid peroxidation, activation of nuclear factor-kappaB, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and nitrotyrosine staining.	Arginine	6-14	tumor necrosis factor	Rattus norvegicus	178-220
11090689-8	2001	We obtained a further, about three-fold increase in the amount of native DsbA-proinsulin by addition of L-arginine or ethanol to the culture medium.	Arginine	104-114	insulin	Homo sapiens	78-88
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Arginine	300-309	tumor protein p53	Homo sapiens	26-29
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Arginine	300-309	tumor protein p53	Homo sapiens	126-129
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Arginine	300-309	tumor protein p53	Homo sapiens	126-129
11730364-4	2001	N-monomethyl-l-arginine (L-NMMA), a specific inhibitor of the l-arginine pathway, inhibited the MCP-1-induced NO secretion and generation of macrophage-mediated tumoricidal activity against P815 (NO-sensitive, TNF-resistant) cells but not the L929 (TNF-sensitive, NO-resistant) cells.	Arginine	13-23	tumor necrosis factor	Mus musculus	210-213
11730364-4	2001	N-monomethyl-l-arginine (L-NMMA), a specific inhibitor of the l-arginine pathway, inhibited the MCP-1-induced NO secretion and generation of macrophage-mediated tumoricidal activity against P815 (NO-sensitive, TNF-resistant) cells but not the L929 (TNF-sensitive, NO-resistant) cells.	Arginine	13-23	tumor necrosis factor	Mus musculus	249-252
11714273-6	2001	The &gt;10-fold increase in activity seen only in the chimeric protein containing the two critical arginine residues demonstrates that the modular C-terminal tail of Cdc25B is the basis for most of the catalytic advantage of Cdc25B versus Cdc25C toward the Cdk2-pTpY/CycA substrate.	Arginine	99-107	cell division cycle 25B	Homo sapiens	166-172
11714273-6	2001	The &gt;10-fold increase in activity seen only in the chimeric protein containing the two critical arginine residues demonstrates that the modular C-terminal tail of Cdc25B is the basis for most of the catalytic advantage of Cdc25B versus Cdc25C toward the Cdk2-pTpY/CycA substrate.	Arginine	99-107	cell division cycle 25B	Homo sapiens	225-231
11708926-4	2001	Inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (SGF) relative to 1, allowing for the incorporation of lipophilic P1" side chains which had the effect of retaining potent TACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall selectivity against MMP1, MMP3, and MMP9.	Arginine	28-36	ADAM metallopeptidase domain 17	Rattus norvegicus	236-240
11564745-3	2001	Negatively charged residues are interspersed within the M2 domains, and substitution of individual acidic residues within human alpha-ENaC with arginine essentially eliminated channel activity in oocytes, suggesting that these residues have a role in ion permeation.	Arginine	144-152	sodium channel epithelial 1 subunit alpha	Homo sapiens	128-138
11717440-5	2001	Higher relative affinity for DOPS-beta 2GPI was achieved by the introduction of Arg residues into the 3H9 H chain variable region at positions previously shown to mediate DNA binding.	Arginine	80-83	apolipoprotein H	Mus musculus	34-43
11553611-1	2001	Open reading frame YJL071W of Saccharomyces cerevisiae was shown to be ARG2 and identified as the structural gene for acetylglutamate synthase, first step in arginine biosynthesis.	Arginine	158-166	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	71-75
11546769-2	2001	L-N(omega),N(omega)-dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is a Zn(II)-containing enzyme that, through hydrolysis of side-chain methylated l-arginines, regulates the activity of nitric-oxide synthase.	Arginine	151-162	dimethylarginine dimethylaminohydrolase 1	Bos taurus	0-61
11546769-2	2001	L-N(omega),N(omega)-dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is a Zn(II)-containing enzyme that, through hydrolysis of side-chain methylated l-arginines, regulates the activity of nitric-oxide synthase.	Arginine	151-162	dimethylarginine dimethylaminohydrolase 1	Bos taurus	63-69
11673894-1	2001	Nitric oxide synthase (NOS) generates nitric oxide (NO*) by the oxidation of l-arginine.	Arginine	77-87	nitric oxide synthase 2	Homo sapiens	0-21
11808895-7	2001	IGF-binding protein (IGFBP)-3 and insulin and arginine-stimulated growth hormone secretion were both normal, indicating normal GH secretion in the majority of patients.	Arginine	46-54	growth hormone 1	Homo sapiens	66-80
11711492-4	2001	Activity of iNOS, determined by the conversion of L-arginine to L-citrulline, increased 9-fold after atorvastatin treatment.	Arginine	50-60	nitric oxide synthase 2	Homo sapiens	12-16
11719829-0	2001	Effect of increased plasma non-esterified fatty acids (NEFAs) on arginine-stimulated insulin secretion in obese humans.	Arginine	65-73	insulin	Homo sapiens	85-92
11606460-6	2001	Active recombinant mKlk21 showed trypsin-like specificity, favorably cleaving Arg-X bonds of synthetic peptide substrates.	Arginine	78-81	kallikrein 1-related peptidase b21	Mus musculus	19-25
21207708-2	2001	Based on a cell-injury model made by ozone (1.5 x 10(-6)) exposure, the present study investigated the protective effect of fibronectin (Fn), a kind of ligand of integrin, and it"s specific sequence Arg-Gly-Asp (RGD peptide) which is a recognizable domain for integrin on BEC.	Arginine	199-202	fibronectin 1	Homo sapiens	124-135
11811381-2	2001	When given acutely, L-arginine derivatives have an antinatriuretic effect that is overridden by elevation of perfusion pressure and both endothelin and angiotensin II play an important role in the systemic and renal haemodynamic alterations associated with impaired nitric oxide availability.	Arginine	20-30	angiotensinogen	Homo sapiens	137-166
11517220-1	2001	Previous studies have demonstrated that the potency and thermodynamic stability of human insulin are enhanced in concert by substitution of Thr(A8) by arginine or histidine.	Arginine	151-159	insulin	Homo sapiens	89-96
11500500-4	2001	The formation of the high affinity complex required Arg-142, Lys-143, Arg-145, Lys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin fragment.	Arginine	52-55	apolipoprotein E	Homo sapiens	105-109
11500500-4	2001	The formation of the high affinity complex required Arg-142, Lys-143, Arg-145, Lys-146, and Arg-147 from apoE and N- and 6-O-sulfo groups of the glucosamine units from the heparin fragment.	Arginine	70-73	apolipoprotein E	Homo sapiens	105-109
11710828-10	2001	The results indicate that women homozygotic for arg/arg in codon 72 of the p53 gene are at an increased risk for the development of cervical adenocarcinomas.	Arginine	48-51	tumor protein p53	Homo sapiens	75-78
11710828-10	2001	The results indicate that women homozygotic for arg/arg in codon 72 of the p53 gene are at an increased risk for the development of cervical adenocarcinomas.	Arginine	52-55	tumor protein p53	Homo sapiens	75-78
11566777-0	2001	Divergent effects of the malignant hyperthermia-susceptible Arg(615)--&gt;Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1.	Arginine	60-63	ryanodine receptor 1	Homo sapiens	130-134
11557524-5	2001	Substitution of Leu at position 1084 of rat MRP3 (which corresponds to Arg-1096 in rat MRP2) with Lys, but not with Val or Met, resulted in the loss of transport activity for TC and glucuronide conjugates.	Arginine	71-74	ATP binding cassette subfamily C member 3	Rattus norvegicus	44-48
11559526-3	2001	Sequencing genomic DNA revealed wild-type MXR/BCRP/ABCP to have an arginine at position 482.	Arginine	67-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	42-45
11572912-0	2001	Low dose L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats.	Arginine	9-19	endothelin 1	Rattus norvegicus	47-59
11694897-9	2001	Fifth, late phase PC appears to depend on HSP72 gene expression mediated by the L-arginine-nitric-oxide pathway; during late phase PC, the inducible nitric oxide synthase (iNOS) content is increased while the eNOS content is unchanged.	Arginine	80-90	heat shock protein family A (Hsp70) member 1A	Homo sapiens	42-47
11562448-9	2001	Transfection of cDNA for the dominant-negative mutant JNK-KR or stress-activated protein kinase kinase-1 Lys--&gt;Arg mutant (SEK1-KR), an immediate upstream kinase of JNK, significantly reduced AAP-induced JNK activation and cell death rate.	Arginine	114-117	mitogen-activated protein kinase kinase 4	Homo sapiens	64-104
11562448-9	2001	Transfection of cDNA for the dominant-negative mutant JNK-KR or stress-activated protein kinase kinase-1 Lys--&gt;Arg mutant (SEK1-KR), an immediate upstream kinase of JNK, significantly reduced AAP-induced JNK activation and cell death rate.	Arginine	114-117	mitogen-activated protein kinase 8	Homo sapiens	168-171
11562448-9	2001	Transfection of cDNA for the dominant-negative mutant JNK-KR or stress-activated protein kinase kinase-1 Lys--&gt;Arg mutant (SEK1-KR), an immediate upstream kinase of JNK, significantly reduced AAP-induced JNK activation and cell death rate.	Arginine	114-117	mitogen-activated protein kinase 8	Homo sapiens	168-171
11564578-1	2001	The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro.	Arginine	54-62	tumor protein p53	Homo sapiens	4-7
11564578-1	2001	The p53 codon 72 polymorphism, resulting in either an arginine or a proline residue has been proposed to affect the susceptibility of p53 protein to human papilloma virus (HPV) E6-mediated degradation in vitro.	Arginine	54-62	tumor protein p53	Homo sapiens	134-137
11553788-4	2001	Mouse apoE, like apoE4, contains the equivalent of Arg-112 and Glu-255, but lacks the critical Arg-61 equivalent (it contains Thr-61).	Arginine	51-54	apolipoprotein E	Mus musculus	6-10
11553788-4	2001	Mouse apoE, like apoE4, contains the equivalent of Arg-112 and Glu-255, but lacks the critical Arg-61 equivalent (it contains Thr-61).	Arginine	95-98	apolipoprotein E	Mus musculus	6-10
11553788-7	2001	Replacing Thr-61 in mouse apoE with arginine converted the binding preference from HDL to very low density lipoproteins in vitro, suggesting that apoE4 domain interaction could be introduced into mouse apoE in vivo.	Arginine	36-44	apolipoprotein E	Homo sapiens	146-151
11553788-7	2001	Replacing Thr-61 in mouse apoE with arginine converted the binding preference from HDL to very low density lipoproteins in vitro, suggesting that apoE4 domain interaction could be introduced into mouse apoE in vivo.	Arginine	36-44	apolipoprotein E	Mus musculus	146-150
11553788-8	2001	Using gene targeting in embryonic stem cells, we created mice expressing Arg-61 apoE.	Arginine	73-76	apolipoprotein E	Mus musculus	80-84
11553788-9	2001	Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism.	Arginine	13-16	apolipoprotein E	Mus musculus	30-34
11553788-9	2001	Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism.	Arginine	13-16	apolipoprotein E	Homo sapiens	80-85
11553788-9	2001	Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism.	Arginine	13-16	apolipoprotein E	Homo sapiens	80-84
11553788-9	2001	Heterozygous Arg-61/wild-type apoE mice displayed two phenotypes found in human apoE4/E3 heterozygotes: preferential binding to lower density lipoproteins and reduced abundance of Arg-61 apoE in the plasma, reflecting its more rapid catabolism.	Arginine	180-183	apolipoprotein E	Mus musculus	30-34
11553788-11	2001	The Arg-61 apoE mouse model will allow the effects of apoE4 domain interaction in lipoprotein metabolism, atherosclerosis, and neurodegeneration to be determined.	Arginine	4-7	apolipoprotein E	Mus musculus	11-15
11553788-11	2001	The Arg-61 apoE mouse model will allow the effects of apoE4 domain interaction in lipoprotein metabolism, atherosclerosis, and neurodegeneration to be determined.	Arginine	4-7	apolipoprotein E	Homo sapiens	54-59
11559526-3	2001	Sequencing genomic DNA revealed wild-type MXR/BCRP/ABCP to have an arginine at position 482.	Arginine	67-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	46-50
11559526-3	2001	Sequencing genomic DNA revealed wild-type MXR/BCRP/ABCP to have an arginine at position 482.	Arginine	67-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	51-55
11432860-4	2001	A search for single substitutions to Gln among all conserved basic residues (Lys/Arg) in human ACE C-domain identified R1098Q as the sole mutant that lacked Cl(-) dependence.	Arginine	81-84	angiotensin I converting enzyme	Homo sapiens	95-98
11432854-9	2001	Mutant RFC complexes containing rfc2-K71R or rfc3-K59R, carrying a conservative lysine --&gt; arginine mutation, had much milder clamp loading defects that could be partially (rfc2-K71R) or completely (rfc3-K59R) suppressed at high ATP concentrations.	Arginine	94-102	replication factor C subunit 3	Saccharomyces cerevisiae S288C	45-49
11461905-10	2001	These results suggest that Acr2p utilizes a phosphatase-like Cys(X)(5)Arg motif as the catalytic center to reduce arsenate to arsenite.	Arginine	70-73	Arr2p	Saccharomyces cerevisiae S288C	27-32
11451953-1	2001	The smallest known open reading frame encodes the ribosomal protein L41, which in yeast is composed of only 24 amino acids, 17 of which are arginine or lysine.	Arginine	140-148	ribosomal protein L41	Homo sapiens	68-71
11522624-7	2001	Four of these seven samples with AGT(ser) mutations also showed a high frequency of codon 249 AGG(arg) to ATG(met) mutations, whereas only one sample showed a codon 250 CCC to ACC transversion.	Arginine	98-101	angiotensinogen	Homo sapiens	33-36
11500310-6	2001	In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization.	Arginine	115-118	dermatan sulfate epimerase like	Homo sapiens	63-67
11500310-6	2001	In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization.	Arginine	115-118	parathyroid hormone	Homo sapiens	96-99
11500310-6	2001	In addition, internalization of the wild-type receptor and the DSEL mutant is stimulated by the PTH analog [Gly(1),Arg(19)]hPTH-(1-28), which does not stimulate phospholipase C. Forskolin, IBMX, and the active phorbol ester, phorbol-12-myristate-13-acetate, did not promote receptor internalization or increase PTH-induced internalization.	Arginine	115-118	parathyroid hormone	Homo sapiens	124-127
11527429-6	2001	S100A4 had a greater affinity for wild-type or mutant arg-175-his p53 than for non-muscle myosin.	Arginine	54-57	tumor protein p53	Homo sapiens	66-69
11500460-3	2001	We have confirmed previous results by demonstrating that stimulation of J774.1 with lipopolysaccharide (LPS) and gamma interferon (IFN-gamma) results in an increase in the uptake of 3H-labeled L-arginine and a concomitant increase in the production of NO.	Arginine	193-203	toll-like receptor 4	Mus musculus	104-107
11522685-7	2001	Insulin secretion in response to arginine (adjusted for insulin sensitivity) was also greater in G/G (9,648 +/- 1,186 pmol/min) than in G/A + A/A (5,686 +/- 720 pmol/min, P = 0.04).	Arginine	33-41	insulin	Homo sapiens	0-7
11522685-8	2001	The acute poststimulus proinsulin-to-insulin ratio was lower in G/G (1.6 +/- 0.4% first phase; 1.6 +/- 0.2% arginine) than in G/A + A/A (4.0 +/- 0.5% first phase, P &lt; 0.001; 2.5 +/- 0.4% arginine, P = 0.03).	Arginine	108-116	insulin	Homo sapiens	23-33
11780385-10	2001	L-arginine ameliorated pulmonary hypertension (16.73 +/- 1.35 mm Hg vs 20.33 +/- 2.18 mm Hg, P &lt; 0.05) as well as pulmonary vascular structural remodeling in the hypoxic rats in association with an increase in plasma NO concentration (P &lt; 0.05) and inhibited ET-1 mRNA expression by the endothelial cells of pulmonary arteries.	Arginine	0-10	endothelin 1	Rattus norvegicus	265-269
11571557-5	2001	A C-to-T transition converting the CGA arginine codon at residue 279 to a TGA termination codon (R279X) was identified by cDNA sequencing.	Arginine	39-47	chromogranin A	Homo sapiens	35-38
11500460-3	2001	We have confirmed previous results by demonstrating that stimulation of J774.1 with lipopolysaccharide (LPS) and gamma interferon (IFN-gamma) results in an increase in the uptake of 3H-labeled L-arginine and a concomitant increase in the production of NO.	Arginine	193-203	interferon gamma	Mus musculus	113-140
11557193-2	2001	The production of TGF-beta1 is genetically controlled as polymorphisms in the signaling sequence of the TGF-beta1 gene leucine(10)--&gt;proline and arginine(25)--&gt;proline are involved in the regulation of the protein production level.	Arginine	148-156	transforming growth factor beta 1	Homo sapiens	18-27
11473357-3	2001	Here we show that agmatine, a metabolite of arginine, inhibits iNOS mediated nitric oxide generation in cytokine stimulated cell culture preparations.	Arginine	44-52	nitric oxide synthase 2	Rattus norvegicus	63-67
11566325-7	2001	The replacement of glycine by the arginine residue in the fifth position of the beta-amyloid peptide sequence changes the coordination modes of a peptide to metal ion in the physiological pH range.	Arginine	34-42	amyloid beta precursor protein	Homo sapiens	80-100
11556547-1	2001	The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS).	Arginine	128-138	nitric oxide synthase 2	Homo sapiens	187-209
11758231-4	2001	RESULT: A single nucleotide substitution T 58G in exon 1, which caused a missense mutation Ser(AGT) 11 Arg(AGG) in signal peptide, was identified by DNA sequencing.	Arginine	103-106	angiotensinogen	Homo sapiens	95-98
11502871-0	2001	Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability.	Arginine	13-23	nitric oxide synthase 2, inducible	Mus musculus	120-151
11502871-1	2001	BACKGROUND: The inducible nitric-oxide synthase (iNOS) synthesizes NO from L-arginine.	Arginine	75-85	nitric oxide synthase 2, inducible	Mus musculus	16-47
11502871-1	2001	BACKGROUND: The inducible nitric-oxide synthase (iNOS) synthesizes NO from L-arginine.	Arginine	75-85	nitric oxide synthase 2, inducible	Mus musculus	49-53
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	90-117
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	119-122
11514672-0	2001	Arginine-140 and isoleucine-141 determine the 17beta-estradiol-binding specificity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	127-131
11514672-1	2001	Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	119-146
11514672-1	2001	Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	148-151
11514672-1	2001	Arginine-140 and isoleucine-141 were identified as key determinants of 17beta-estradiol (E(2)) binding affinity of the sex-steroid-binding protein (SBP, or SHBG) of human plasma.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	156-160
11404359-0	2001	Identification of a missense mutation (G329A;Arg(110)--&gt; GLN) in the human FUT7 gene.	Arginine	45-48	fucosyltransferase 7	Homo sapiens	78-82
11520213-2	2001	Molecular modeling (docking) studies showed that the azido substituent of these two analogues (13, 17) was inserted deep into the secondary pocket of the human COX-2 binding site where it undergoes electrostatic interaction with Arg(513).	Arginine	229-232	prostaglandin-endoperoxide synthase 2	Homo sapiens	160-165
11404359-5	2001	The coding regions of the FUT7 gene from this individual were cloned, and a G329A point mutation (Arg(110) --&gt; Gln) was found in one allele, whereas the other FUT7 allele was wild type.	Arginine	98-101	fucosyltransferase 7	Homo sapiens	26-30
11404359-7	2001	The FUT7 Arg(110) is conserved in all previously cloned vertebrate alpha 1,3-fucosyltransferases.	Arginine	9-12	fucosyltransferase 7	Homo sapiens	4-8
11500030-6	2001	The sequence of bombinakinin M is preceded by a single basic residue (arginine), which represents the site of cleavage for releasing of mature bombinakinin M. This is the first cDNA cloning of bradykinin-related peptides from amphibian skin.	Arginine	70-78	kininogen 1	Homo sapiens	193-203
11513842-7	2001	Alone of the NO donors, low concentrations of L-arginine produced a mild inhibition of histamine release induced by anti-IgE, compound 48/80 and A23187, but not other ligands, while sodium nitroprusside dose-dependently inhibited (by a maximum of ca.	Arginine	46-56	immunoglobulin heavy constant epsilon	Homo sapiens	121-124
11387337-6	2001	Through site-directed mutagenesis, we defined the ERK/p38-binding site as a cluster of arginine residues in the NH(2)-terminal domain of MKP-2.	Arginine	87-95	mitogen-activated protein kinase 1	Homo sapiens	50-53
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	65-68	angiotensin I converting enzyme	Homo sapiens	32-35
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	65-68	angiotensin I converting enzyme	Homo sapiens	165-168
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	110-113	angiotensin I converting enzyme	Homo sapiens	32-35
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	110-113	angiotensin I converting enzyme	Homo sapiens	165-168
11485568-8	2001	These results are consistent with a relatively open distal pocket that allows CO to bind unhindered in the active site of murine iNOS in the absence of L-arginine or BH(4).	Arginine	152-162	nitric oxide synthase 2, inducible	Mus musculus	129-133
11478907-3	2001	A compound consisting merely of the cyclic core of hMCH with the Arg attached to the N-terminus of the disulfide ring was found to activate both hMCH-1R and hMCH-2R about as effectively as full-length hMCH.	Arginine	65-68	pro-melanin concentrating hormone	Homo sapiens	51-55
11478907-3	2001	A compound consisting merely of the cyclic core of hMCH with the Arg attached to the N-terminus of the disulfide ring was found to activate both hMCH-1R and hMCH-2R about as effectively as full-length hMCH.	Arginine	65-68	pro-melanin concentrating hormone	Homo sapiens	145-149
11478907-3	2001	A compound consisting merely of the cyclic core of hMCH with the Arg attached to the N-terminus of the disulfide ring was found to activate both hMCH-1R and hMCH-2R about as effectively as full-length hMCH.	Arginine	65-68	pro-melanin concentrating hormone	Homo sapiens	145-149
11478907-3	2001	A compound consisting merely of the cyclic core of hMCH with the Arg attached to the N-terminus of the disulfide ring was found to activate both hMCH-1R and hMCH-2R about as effectively as full-length hMCH.	Arginine	65-68	pro-melanin concentrating hormone	Homo sapiens	145-149
11387337-6	2001	Through site-directed mutagenesis, we defined the ERK/p38-binding site as a cluster of arginine residues in the NH(2)-terminal domain of MKP-2.	Arginine	87-95	mitogen-activated protein kinase 1	Homo sapiens	54-57
11487527-3	2001	Rabbit aortic SMCs express a baseline population of B(1)Rs that was up-regulated upon interleukin-1beta treatment ([(3)H]-Lys-des-Arg(9)-BK binding or mRNA concentration evaluated by RT - PCR; 4 or 3 h, respectively).	Arginine	129-133	interleukin-1 beta	Oryctolagus cuniculus	86-103
11463332-3	2001	The crystal structures of the oxygenase domains of inducible NOS (iNOS) and vascular endothelial NOS (eNOS) allow us to interpret other information in the context of this important part of the enzyme, with its binding sites for iron protoporphyrin IX (haem), biopterin, L-arginine, and the many inhibitors which interact with them.	Arginine	270-280	nitric oxide synthase 2	Homo sapiens	51-64
11463332-3	2001	The crystal structures of the oxygenase domains of inducible NOS (iNOS) and vascular endothelial NOS (eNOS) allow us to interpret other information in the context of this important part of the enzyme, with its binding sites for iron protoporphyrin IX (haem), biopterin, L-arginine, and the many inhibitors which interact with them.	Arginine	270-280	nitric oxide synthase 2	Homo sapiens	66-70
11463332-3	2001	The crystal structures of the oxygenase domains of inducible NOS (iNOS) and vascular endothelial NOS (eNOS) allow us to interpret other information in the context of this important part of the enzyme, with its binding sites for iron protoporphyrin IX (haem), biopterin, L-arginine, and the many inhibitors which interact with them.	Arginine	270-280	nitric oxide synthase 3	Homo sapiens	85-100
11443071-6	2001	Diamide treatment of either PAECs, PAEC membrane fractions, or purified endothelial nitric oxide synthase (eNOS) resulted in significant inhibition (approximately 75%) of eNOS catalytic activity measured as L-[(3)H]arginine-to-L-[(3)H]citrulline conversion.	Arginine	215-223	nitric oxide synthase 3	Homo sapiens	72-105
11443071-6	2001	Diamide treatment of either PAECs, PAEC membrane fractions, or purified endothelial nitric oxide synthase (eNOS) resulted in significant inhibition (approximately 75%) of eNOS catalytic activity measured as L-[(3)H]arginine-to-L-[(3)H]citrulline conversion.	Arginine	215-223	nitric oxide synthase 3	Homo sapiens	107-111
11511294-5	2001	This mutation converts the CGA codon of arginine at amino acid 579 to a UGA stop codon resulting in marked truncation of the 940 amino acid xeroderma pigmentosum C protein.	Arginine	40-48	chromogranin A	Homo sapiens	27-30
11454802-0	2001	Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells.	Arginine	0-8	selenoprotein K	Rattus norvegicus	80-98
11470762-3	2001	In the present study, we demonstrate that an arginine residue at position 216, which is conserved in some but not all mammalian class Alpha GSTs, plays an important role in catalytic activity of mGSTA1-1 toward (+)-anti-BPDE and carcinogenic diol epoxides of other environmentally relevant polycyclic aromatic hydrocarbons (PAHs).	Arginine	45-53	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	140-144
11470762-3	2001	In the present study, we demonstrate that an arginine residue at position 216, which is conserved in some but not all mammalian class Alpha GSTs, plays an important role in catalytic activity of mGSTA1-1 toward (+)-anti-BPDE and carcinogenic diol epoxides of other environmentally relevant polycyclic aromatic hydrocarbons (PAHs).	Arginine	45-53	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	195-201
11470762-8	2001	The results of the present study clearly indicate that an arginine residue at position 216 is critical for catalytic activity of mGSTA1-1 and mGSTA2-2 toward carcinogenic diol epoxide metabolites of various PAHs that are abundant in the environment and suspected human carcinogens.	Arginine	58-66	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	129-137
11529920-3	2001	The sequence of TAP2 gene identified a single mutation, a C to T substitution changing the CGA arg codon at amino acid 220 into TGA stop codon in exon 3.	Arginine	95-98	chromogranin A	Homo sapiens	91-94
11529286-0	2001	Response of nitric oxide pathway to L-arginine infusion at the altitude of 4,350 m. It was hypothesized that hypoxia may inhibit nitric oxide (NO) production by reducing the availability of endothelial NO synthase (NOS III) substrate.	Arginine	36-46	nitric oxide synthase 3	Homo sapiens	215-222
11523086-10	2001	The presence of two highly basic arginine residues on bradykinin results in its high GB(app), while the basicity of des-Arg1-bradykinin ions is increased by the presence of two proline residues at the N-terminus.	Arginine	33-41	kininogen 1	Homo sapiens	54-64
11474471-5	2001	On the other hand, arginine, which is known as an inhibitor of renal tubular reabsorption, increased urinary excretion of Leu-A3 insulin.	Arginine	19-27	insulin	Homo sapiens	129-136
11483712-11	2001	Stimulation of endogenous NO production by L-arginine was also effective in releasing VIP.	Arginine	43-53	vasoactive intestinal peptide	Rattus norvegicus	86-89
11473630-7	2001	A mutation in COL4A4 that changed C to T resulting in an arginine residue being replaced by a stop codon (R1377X) was demonstrated in exon 44, which encodes part of the alpha 4(IV) collagen sequence close to the junction with the noncollagenous domain.	Arginine	57-65	collagen type IV alpha 4 chain	Homo sapiens	14-20
11474471-7	2001	A large amount of Leu-A3 insulin is excreted in urine when reabsorption of insulin at renal tubules is inhibited by arginine.	Arginine	116-124	insulin	Homo sapiens	25-32
11479422-4	2001	As the pivotal residues around the most predominant R24C activating CDK4 mutation are invariant between CDK2 and CDK4, we speculated that the pivotal arginine (position 22 in CDK2), or a nearby residue, may be mutated in some melanomas, resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1.	Arginine	150-158	cyclin dependent kinase inhibitor 1A	Homo sapiens	309-316
11474471-7	2001	A large amount of Leu-A3 insulin is excreted in urine when reabsorption of insulin at renal tubules is inhibited by arginine.	Arginine	116-124	insulin	Homo sapiens	75-82
11459667-0	2001	Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors.	Arginine	76-84	coagulation factor II, thrombin	Homo sapiens	114-122
11733654-4	2001	DNA sequence analysis of the propositus demonstrated a point mutation at codon 365 (GGA-CGA), resulting in a Gly-Arg substitution.	Arginine	113-116	chromogranin A	Homo sapiens	88-91
11473257-1	2001	Nitric oxide synthase is inhibited by asymmetric NG-methylated derivatives of arginine whose cellular levels are controlled in part by dimethylarginine dimethylaminohydrolase (DDAH, EC 3.5.3.18).	Arginine	78-86	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	135-174
11473257-1	2001	Nitric oxide synthase is inhibited by asymmetric NG-methylated derivatives of arginine whose cellular levels are controlled in part by dimethylarginine dimethylaminohydrolase (DDAH, EC 3.5.3.18).	Arginine	78-86	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	176-180
11473257-3	2001	Here, the first structure of a DDAH shows an unexpected similarity to arginine:glycine amidinotransferase (EC 2.1.4.1) and arginine deiminase (EC 3.5.3.6), thus defining a superfamily of arginine-modifying enzymes.	Arginine	70-78	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	31-35
11473257-3	2001	Here, the first structure of a DDAH shows an unexpected similarity to arginine:glycine amidinotransferase (EC 2.1.4.1) and arginine deiminase (EC 3.5.3.6), thus defining a superfamily of arginine-modifying enzymes.	Arginine	123-131	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	31-35
11500547-5	2001	This interaction was greatly reduced when lysine-462 of PRK1-K, believed to be essential for kinase activity, was replaced with arginine (the resulting protein is named PRK1-K462R).	Arginine	128-136	serine/threonine protein kinase PRK1	Saccharomyces cerevisiae S288C	56-60
11500547-5	2001	This interaction was greatly reduced when lysine-462 of PRK1-K, believed to be essential for kinase activity, was replaced with arginine (the resulting protein is named PRK1-K462R).	Arginine	128-136	serine/threonine protein kinase PRK1	Saccharomyces cerevisiae S288C	169-173
11313365-9	2001	Mutational analysis of ILK further shows a crucial role for arginine 211 of ILK within the phosphoinositide phospholipid binding domain in the regulation of PKB- serine 473 phosphorylation.	Arginine	60-68	integrin linked kinase	Homo sapiens	23-26
11313365-9	2001	Mutational analysis of ILK further shows a crucial role for arginine 211 of ILK within the phosphoinositide phospholipid binding domain in the regulation of PKB- serine 473 phosphorylation.	Arginine	60-68	integrin linked kinase	Homo sapiens	76-79
11313365-9	2001	Mutational analysis of ILK further shows a crucial role for arginine 211 of ILK within the phosphoinositide phospholipid binding domain in the regulation of PKB- serine 473 phosphorylation.	Arginine	60-68	AKT serine/threonine kinase 1	Homo sapiens	157-160
11331277-4	2001	Chemical modification of lysines and arginines in apoB or mutation of its main proteoglycan binding site did not abolish the interaction of LDL with LPL as shown by surface plasmon resonance (SPR) and by experiments with THP-I macrophages.	Arginine	37-46	apolipoprotein B	Homo sapiens	50-54
11438644-2	2001	Alanine scanning mutagenesis of the Cy motif of the cdk inhibitor p21 revealed that the conserved arginine or leucine (constituting the conserved RXL sequence) was important for p21"s ability to inhibit cyclin E-cdk2 activity.	Arginine	98-106	cyclin dependent kinase inhibitor 1A	Homo sapiens	66-69
11438644-2	2001	Alanine scanning mutagenesis of the Cy motif of the cdk inhibitor p21 revealed that the conserved arginine or leucine (constituting the conserved RXL sequence) was important for p21"s ability to inhibit cyclin E-cdk2 activity.	Arginine	98-106	cyclin dependent kinase inhibitor 1A	Homo sapiens	178-181
11467957-0	2001	Structural requirements for conserved arginine of parathyroid hormone.	Arginine	38-46	parathyroid hormone	Homo sapiens	50-69
11467957-1	2001	Arg-20 is one of two residues conserved in all peptides known to activate the parathyroid hormone (PTH) receptor.	Arginine	0-3	parathyroid hormone	Homo sapiens	78-97
11373285-1	2001	Upon sequence alignment of CYP51 sterol 14alpha-demethylase from animals, plants, fungi, and bacteria, arginine corresponding to Arg-448 of CYP51 in Mycobacterium tuberculosis (MT) is conserved near the C terminus of all family members.	Arginine	103-111	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	27-32
11373285-1	2001	Upon sequence alignment of CYP51 sterol 14alpha-demethylase from animals, plants, fungi, and bacteria, arginine corresponding to Arg-448 of CYP51 in Mycobacterium tuberculosis (MT) is conserved near the C terminus of all family members.	Arginine	103-111	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	140-145
11373285-1	2001	Upon sequence alignment of CYP51 sterol 14alpha-demethylase from animals, plants, fungi, and bacteria, arginine corresponding to Arg-448 of CYP51 in Mycobacterium tuberculosis (MT) is conserved near the C terminus of all family members.	Arginine	129-132	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	27-32
11373285-1	2001	Upon sequence alignment of CYP51 sterol 14alpha-demethylase from animals, plants, fungi, and bacteria, arginine corresponding to Arg-448 of CYP51 in Mycobacterium tuberculosis (MT) is conserved near the C terminus of all family members.	Arginine	129-132	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	140-145
11373285-6	2001	C-terminal truncation of Candida albicans and human CYP51 orthologs reveals that, despite conservation in sequence, the requirement for arginine at the homologous C-terminal position in folding in E. coli is not conserved.	Arginine	136-144	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	52-57
11313365-0	2001	Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.	Arginine	140-148	AKT serine/threonine kinase 1	Homo sapiens	31-34
11313365-0	2001	Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.	Arginine	140-148	integrin linked kinase	Homo sapiens	65-87
11459667-0	2001	Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors.	Arginine	99-107	coagulation factor II, thrombin	Homo sapiens	114-122
11459667-1	2001	Seven non-natural analogues of arginine and lysine have been substituted in an established arginine-based thrombin inhibitor.	Arginine	31-39	coagulation factor II, thrombin	Homo sapiens	106-114
11459667-1	2001	Seven non-natural analogues of arginine and lysine have been substituted in an established arginine-based thrombin inhibitor.	Arginine	91-99	coagulation factor II, thrombin	Homo sapiens	106-114
11406469-5	2001	In the presence of L-NAME (3 x 10(-5) M) and L-arginine (1 x 10(-3) M), the L-NAME-induced inhibition in the PTHrP-(1-34)-mediated responses was significantly reduced.	Arginine	45-55	parathyroid hormone-like peptide	Mus musculus	109-114
11401828-2	2001	Double point mutations of arginines in this post-M2 region of the human alpha-ENaC (alpha-hENaC) led to a decrease and increase in the macroscopic conductance of alphaR586E,R587Ebetagamma- and alphaR589E,R591Ebetagamma-hENaC, respectively, but had no effect on the single-channel conductance of either double point mutant.	Arginine	26-35	sodium channel epithelial 1 subunit alpha	Homo sapiens	72-82
11401828-2	2001	Double point mutations of arginines in this post-M2 region of the human alpha-ENaC (alpha-hENaC) led to a decrease and increase in the macroscopic conductance of alphaR586E,R587Ebetagamma- and alphaR589E,R591Ebetagamma-hENaC, respectively, but had no effect on the single-channel conductance of either double point mutant.	Arginine	26-35	sodium channel epithelial 1 subunit alpha	Homo sapiens	84-95
11433181-2	2001	L-arginine is the substrate required for NO production by endothelial NOS (eNOS).	Arginine	0-10	nitric oxide synthase 3	Bos taurus	58-73
11518751-3	2001	PCR/direct sequencing analysis revealed the presence of a nucleotide substitution, AGC (Ser) to AGG (Arg), at codon 106 of the p53 gene in DNA from non-cancerous breast tissue.	Arginine	101-104	tumor protein p53	Homo sapiens	127-130
11418470-11	2001	RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN.	Arginine	6-9	fibronectin 1	Homo sapiens	134-141
11423511-0	2001	Diminished insulin secretory response to glucose but normal insulin and glucagon secretory responses to arginine in a family with maternally inherited diabetes and deafness caused by mitochondrial tRNA(LEU(UUR)) gene mutation.	Arginine	104-112	mitochondrially encoded tRNA glycine	Homo sapiens	197-210
11423511-8	2001	CONCLUSIONS: This study shows impaired insulin and C-peptide secretion in response to a glucose challenge and to glucagon stimulation in diabetic patients with mitochondrial tRNA Leu(UUR) gene mutation, although insulin and glucagon secretory responses to arginine were normal.	Arginine	256-264	mitochondrially encoded tRNA glycine	Homo sapiens	183-186
11423511-8	2001	CONCLUSIONS: This study shows impaired insulin and C-peptide secretion in response to a glucose challenge and to glucagon stimulation in diabetic patients with mitochondrial tRNA Leu(UUR) gene mutation, although insulin and glucagon secretory responses to arginine were normal.	Arginine	256-264	insulin	Homo sapiens	39-46
11429426-2	2001	A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies.	Arginine	141-149	tumor protein p53	Homo sapiens	52-55
11429426-2	2001	A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies.	Arginine	141-149	tumor protein p53	Homo sapiens	180-183
11429426-7	2001	RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population.	Arginine	66-74	tumor protein p53	Homo sapiens	28-31
11429426-7	2001	RESULTS: The proportions of p53 codon 72 genotypes found were 78% arginine homozygous, 2% proline homozygous, and 20% heterozygous among patients with skin cancer and 79% arginine homozygous, 3.5% proline homozygous, and 17.5% heterozygous among the control population.	Arginine	171-179	tumor protein p53	Homo sapiens	28-31
11433181-2	2001	L-arginine is the substrate required for NO production by endothelial NOS (eNOS).	Arginine	0-10	nitric oxide synthase 3	Bos taurus	75-79
11433181-8	2001	eNOS activity in forming NO was determined by assay for 3H-L-arginine to 3H-citrulline conversion.	Arginine	56-69	nitric oxide synthase 3	Bos taurus	0-4
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	24-27	mitogen-activated protein kinase 1	Homo sapiens	157-161
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	32-35	mitogen-activated protein kinase 1	Homo sapiens	157-161
11442318-10	2001	The activity of iNOS was also enhanced by CGRP as compared with LPS-stimulation alone by detecting the 3H-L-citruline formation from 3H-L-arginine.	Arginine	133-146	nitric oxide synthase 2, inducible	Mus musculus	16-20
11437602-5	2001	The lack of caspase 3 activity was found to be the result of a fortuitous mutation in which Trp(206) in the S4 subsite was replaced by arginine (W206R).	Arginine	135-143	caspase 3	Homo sapiens	12-21
11275358-1	2001	The biochemistry and physiology of L-arginine have to be reconsidered in the light of the recent discovery that the amino acid is the only substrate of all isoforms of nitric oxide synthase (NOS).	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	168-189
11442318-10	2001	The activity of iNOS was also enhanced by CGRP as compared with LPS-stimulation alone by detecting the 3H-L-citruline formation from 3H-L-arginine.	Arginine	133-146	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	42-46
11274151-4	2001	Incubation of the cells at 15 degrees C revealed that ACE(NQ) was cleaved in the endoplasmic reticulum, and mass spectrometric analysis of the secreted form of the protein indicated that it had been cleaved at the Asn(635)-Ser(636) bond, three residues N-terminal to the normal secretase cleavage site at Arg(638)-Ser(639).	Arginine	305-308	angiotensin I converting enzyme	Homo sapiens	54-57
11320079-7	2001	Site-directed mutagenesis experiments showed that replacement of the histidine with alanine, asparagine, aspartate, glutamate, glutamine, or arginine in N(t)-FDH resulted in expression of insoluble proteins.	Arginine	141-149	aldehyde dehydrogenase 1 family member L1	Homo sapiens	153-161
11406294-4	2001	iNOS mRNA was strongly induced after treatment and reached a maximum at 6-12 h. mRNA for argininosuccinate synthetase (AS), a citrulline-arginine recycling enzyme, increased at 6 h and reached a maximum at 12 h. Immunoblot analysis showed that iNOS and AS proteins were also induced.	Arginine	137-145	nitric oxide synthase 2, inducible	Mus musculus	0-4
11312270-1	2001	Inducible nitric-oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	0-31
11312270-1	2001	Inducible nitric-oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	33-37
11390518-3	2001	Exon-specific amplification of genomic DNA by PCR followed by direct sequence analysis revealed a homozygous nonsense mutation in the C1s gene exon XII at codon 534, caused by a nucleotide substitution from C (CGA for arginine) to T (TGA for stop codon).	Arginine	218-226	complement C1s	Homo sapiens	134-137
11389017-4	2001	The antibody-bound prothrombin formed a stable stoichiometric complex with antithrombin III, consisting of intact prothrombin and an antithrombin III molecule cleaved at the (393)Arg-(394)Ser bond.	Arginine	179-182	coagulation factor II, thrombin	Homo sapiens	19-30
11389602-1	2001	A ferric heme-nitric oxide (NO) complex can build up in mouse inducible nitric oxide synthase (iNOS) during NO synthesis from L-arginine.	Arginine	126-136	nitric oxide synthase 2, inducible	Mus musculus	62-93
11439928-10	2001	Additional hIK1/rSK2 chimeras defined the minimal region of hIK1 required to confer complete ATP sensitivity as including amino acids Arg(355)-Ala(413).	Arginine	134-137	potassium calcium-activated channel subfamily N member 2	Rattus norvegicus	16-20
11439928-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 2	Rattus norvegicus	101-105
11389602-1	2001	A ferric heme-nitric oxide (NO) complex can build up in mouse inducible nitric oxide synthase (iNOS) during NO synthesis from L-arginine.	Arginine	126-136	nitric oxide synthase 2, inducible	Mus musculus	95-99
11435962-2	2001	We hypothesized that l-arginine polymers administered to cardiac allografts ex vivo would translocate across vascular cellular membranes, up-regulate inducible nitric oxide synthase (iNOS) production of NO, and inhibit the development of GCAD.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	150-181
11312270-5	2001	Furthermore, proteasomal inhibition blocked the degradation of an iNOS splice variant that lacked the capacity to dimerize and of an iNOS mutant that lacks l-arginine binding ability, suggesting that iNOS is targeted by proteasomes, notwithstanding its capacity to produce NO, dimerize, or bind the substrate.	Arginine	156-166	nitric oxide synthase 2	Homo sapiens	66-70
11435962-2	2001	We hypothesized that l-arginine polymers administered to cardiac allografts ex vivo would translocate across vascular cellular membranes, up-regulate inducible nitric oxide synthase (iNOS) production of NO, and inhibit the development of GCAD.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	183-187
11312270-5	2001	Furthermore, proteasomal inhibition blocked the degradation of an iNOS splice variant that lacked the capacity to dimerize and of an iNOS mutant that lacks l-arginine binding ability, suggesting that iNOS is targeted by proteasomes, notwithstanding its capacity to produce NO, dimerize, or bind the substrate.	Arginine	156-166	nitric oxide synthase 2	Homo sapiens	133-137
11312270-5	2001	Furthermore, proteasomal inhibition blocked the degradation of an iNOS splice variant that lacked the capacity to dimerize and of an iNOS mutant that lacks l-arginine binding ability, suggesting that iNOS is targeted by proteasomes, notwithstanding its capacity to produce NO, dimerize, or bind the substrate.	Arginine	156-166	nitric oxide synthase 2	Homo sapiens	133-137
11380262-6	2001	Mutation of the P1 arginine greatly reduced k(assoc) for antithrombin inhibition of thrombin and factor Xa from 40- to 5000-fold, but heparin normally accelerated the reactions of the variant antithrombins with these enzymes to make them reasonably efficient inhibitors (k(assoc) = 10(3)-10(4) M(-1) s(-1)).	Arginine	19-27	coagulation factor II, thrombin	Homo sapiens	61-69
11304524-5	2001	Remarkably, the guanido group of arginine at position -1 of the CFTR peptide forms two salt bridges and two hydrogen bonds with PDZ1 residues Glu(43) and Asn(22), respectively, providing the structural basis for the contribution of the penultimate amino acid of the peptide ligand to the affinity of the interaction.	Arginine	33-41	CF transmembrane conductance regulator	Homo sapiens	64-68
11380262-10	2001	Together, these findings suggest that the P1 arginine residue is similarly accessible to proteinases in both native and heparin-activated states of the serpin and contributes similarly to the specificity of antithrombin for thrombin and factor Xa in the two serpin conformational states.	Arginine	45-53	coagulation factor II, thrombin	Homo sapiens	211-219
11378370-2	2001	Fibronectin contains the active sequence Arg-Gly-Asp (RGD), along with its synergic site Pro-His-Ser-Arg-Asn (PHSRN).	Arginine	41-44	fibronectin 1	Homo sapiens	0-11
11378370-2	2001	Fibronectin contains the active sequence Arg-Gly-Asp (RGD), along with its synergic site Pro-His-Ser-Arg-Asn (PHSRN).	Arginine	101-104	fibronectin 1	Homo sapiens	0-11
11350743-4	2001	Twisting integrin receptors with RGD (Arg-Gly-Asp)-containing peptide-coated beads increased endothelin-1 (ET-1) gene expression by &gt;100%.	Arginine	38-41	endothelin 1	Homo sapiens	93-105
11410740-7	2001	IFN-gamma in combination with TNF-alpha induced NO production with an enhancement in CAT-2B mRNA expression and L-arginine transport, whereas L-arginine transport and NO production were suppressed by coincubated ethanol.	Arginine	112-122	tumor necrosis factor	Rattus norvegicus	30-39
11350743-4	2001	Twisting integrin receptors with RGD (Arg-Gly-Asp)-containing peptide-coated beads increased endothelin-1 (ET-1) gene expression by &gt;100%.	Arginine	38-41	endothelin 1	Homo sapiens	107-111
11369804-1	2001	We previously showed 1 that a peptide, Ac-hE18A-NH(2), in which the arginine-rich heparin-binding domain of apolipoprotein E (apoE) [residues 141;-150] (LRKLRKRLLR), covalently linked to 18A (DWLKAFYDKVAEKLKEAF; a class A amphipathic helix with high lipid affinity), enhanced LDL uptake and clearance.	Arginine	68-76	apolipoprotein E	Homo sapiens	108-124
11319798-2	2001	A germline 3-bp insertion in exon 2 of CDKN2A, leading to an extra arginine at codon 113 (113insR), has been identified in 17 Swedish melanoma families.	Arginine	67-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	39-45
11395042-0	2001	Relationship of age-related myocardial infarction risk and Gln/Arg 192 variants of the human paraoxonase1 gene: the REGICOR study.	Arginine	63-66	paraoxonase 1	Homo sapiens	93-105
11375254-1	2001	It was tested whether the inducible nitric oxide synthase (iNOS) pathway might be involved in lipopolysaccharides-(LPS)-induced up-regulation of L-arginine transport in rat alveolar macrophages (AM).	Arginine	145-155	nitric oxide synthase 2	Rattus norvegicus	59-63
11375254-6	2001	However, AMT present during culture additionally to LPS, suppressed LPS-induced nitrite accumulation and LPS-stimulated [3H]-L-arginine uptake in the same concentration-dependent manner.	Arginine	125-135	aminomethyltransferase	Rattus norvegicus	9-12
11375254-7	2001	AMT present only for the last 30 min of the culture period had similar effects on [3H]-L-arginine uptake.	Arginine	87-97	aminomethyltransferase	Rattus norvegicus	0-3
11375254-8	2001	AMT present only during the uptake period also inhibited LPS-stimulated [3H]-L-arginine uptake, but with lower potency.	Arginine	77-87	aminomethyltransferase	Rattus norvegicus	0-3
11375254-12	2001	In conclusion, iNOS inhibition in rat AM abolished LPS-activated L-arginine uptake.	Arginine	65-75	nitric oxide synthase 2	Rattus norvegicus	15-19
11375254-13	2001	This effect appears to be caused by reduced flow of L-arginine through the iNOS pathway.	Arginine	52-62	nitric oxide synthase 2	Rattus norvegicus	75-79
26680792-9	2001	CONCLUSION: These findings suggest that Arg/Arg homozygocity of the p53 codon 72 would be a protective factor against the development of cervical adenocarcinoma.	Arginine	40-43	tumor protein p53	Homo sapiens	68-71
26680792-9	2001	CONCLUSION: These findings suggest that Arg/Arg homozygocity of the p53 codon 72 would be a protective factor against the development of cervical adenocarcinoma.	Arginine	44-47	tumor protein p53	Homo sapiens	68-71
11369801-1	2001	The apolipoprotein A-I(Milano) (apoA-I(M)) is a molecular variant of apoA-I characterized by the Arg(173)--&gt;Cys substitution, leading to the formation of homodimers A-I(M)/A-I(M).	Arginine	97-100	apolipoprotein A1	Homo sapiens	4-30
11369801-1	2001	The apolipoprotein A-I(Milano) (apoA-I(M)) is a molecular variant of apoA-I characterized by the Arg(173)--&gt;Cys substitution, leading to the formation of homodimers A-I(M)/A-I(M).	Arginine	97-100	apolipoprotein A1	Homo sapiens	32-38
11369801-1	2001	The apolipoprotein A-I(Milano) (apoA-I(M)) is a molecular variant of apoA-I characterized by the Arg(173)--&gt;Cys substitution, leading to the formation of homodimers A-I(M)/A-I(M).	Arginine	97-100	apolipoprotein A1	Homo sapiens	69-75
11369801-7	2001	Cleavage in the middle of apoA-I occurs at distinct sites in 7.8-nm (Lys(118)) and 12.7-nm (Arg(123)) rHDL, indicating a different conformation in small and large rHDL particles.	Arginine	92-95	apolipoprotein A1	Homo sapiens	26-32
11369804-1	2001	We previously showed 1 that a peptide, Ac-hE18A-NH(2), in which the arginine-rich heparin-binding domain of apolipoprotein E (apoE) [residues 141;-150] (LRKLRKRLLR), covalently linked to 18A (DWLKAFYDKVAEKLKEAF; a class A amphipathic helix with high lipid affinity), enhanced LDL uptake and clearance.	Arginine	68-76	apolipoprotein E	Homo sapiens	126-130
11593962-1	2001	Arginase and nitric oxide synthase (NOS) compete for the same substrate, L-arginine.	Arginine	73-83	nitric oxide synthase 2	Homo sapiens	13-34
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Arginine	226-229	growth hormone 1	Homo sapiens	37-39
11430833-2	2001	Here, we demonstrate that the insulin-induced inhibition of GSK3 and its unique substrate specificity are explained by the existence of a phosphate binding site in which Arg-96 is critical.	Arginine	170-173	insulin	Homo sapiens	30-37
11477223-9	2001	Mutation of Trp (70) to Arg abolished binding to both lysine-Sepharose and plasmin-modified fibrinogen, while the Trp (70) --&gt;Phe and Arg (35) --&gt;Lys substitutions each resulted in decreased binding to these substrates.	Arginine	24-27	fibrinogen beta chain	Homo sapiens	92-102
11419962-6	2001	The l -arginine pretreatment attenuated the increases in iNOS and MPO activities and nitrite/nitrate concentration and the decrease in cNOS activity in the gastric mucosal tissue in a dose-dependent manner, while the d -arginine pretreatment did not.	Arginine	4-15	nitric oxide synthase 2	Rattus norvegicus	57-61
11292821-1	2001	Endothelial nitric-oxide synthase (eNOS) is an important regulatory enzyme in the cardiovascular system catalyzing the production of NO from arginine.	Arginine	141-149	nitric oxide synthase 3	Homo sapiens	0-33
11412395-6	2001	The kinetic analysis of this iNOS demonstrated specific constants of Km=10.8 micromol/L, Vmax=263.2 pmol/min/mg protein(for L-Arg), and Ki of 0.56, 0.94 micromol/L for competitive inhibitor, L-NMMA and NNA, respectively.	Arginine	124-129	nitric oxide synthase 2	Rattus norvegicus	29-33
11336634-1	2001	Besides oxidizing L-arginine, neuronal NO synthase (NOS) NADPH-dependently reduces various electron acceptors, including cytochrome c and tetrazolium salts.	Arginine	18-28	nitric oxide synthase 2	Homo sapiens	39-50
11350073-8	2001	The reduced ability of diabetic tissue to convert l-arginine to l-citrulline via nitric oxide synthase was reversed by the selective inhibition of arginase by 2(S)-amino-6-boronohexanoic acid (ABH).	Arginine	50-60	nitric oxide synthase 2	Homo sapiens	81-102
11278474-6	2001	Inactivation by MTSET was five times faster in GlyT2a-A223C than in GlyT2a-EL1 or GlyT1b, suggesting that the arginine in position +2 reduced the cysteine reactivity.	Arginine	110-118	ELAV (embryonic lethal, abnormal vision)-like 2 (Hu antigen B)	Xenopus laevis	75-78
11278474-6	2001	Inactivation by MTSET was five times faster in GlyT2a-A223C than in GlyT2a-EL1 or GlyT1b, suggesting that the arginine in position +2 reduced the cysteine reactivity.	Arginine	110-118	solute carrier family 6 member 9 S homeolog	Xenopus laevis	82-88
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Arginine	40-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-21
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Arginine	40-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-21
11278488-8	2001	Substitution of c-Src RT loop residues (Arg-97 and Thr-98) for those found in the v-Src SH3 domain (Trp-97 and Ile-98) enhanced the binding of distinct NIH3T3 cellular proteins to a glutathione S-transferase fusion protein of the c-Src (Trp-97 + Ile-98) SH3 domain.	Arginine	40-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	230-235
11341840-7	2001	Two of the N-terminal sites, Arg-17 and Arg-26, occur in the sequence KAXRK and appear to be more efficiently methylated than Arg-2.	Arginine	29-32	arginase 2	Bos taurus	40-45
11150296-0	2001	Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.	Arginine	0-8	interferon alpha 1	Homo sapiens	55-65
11350936-1	2001	The Tat (twin-arginine translocation) pathway is a Sec-independent mechanism for translocating folded preproteins across or into the inner membrane of Escherichia coli.	Arginine	14-22	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	4-7
11278602-2	2001	Sustained NO production via the inducible enzyme, nitric-oxide synthase 2 (NOS2), requires extracellular arginine uptake.	Arginine	105-113	nitric oxide synthase 2, inducible	Mus musculus	50-73
11150296-8	2001	The results suggest that two arginine/lysine-rich elements, one in each STAT monomer, are required for IFN-induced nuclear import of STAT dimers.	Arginine	29-37	interferon alpha 1	Homo sapiens	103-106
11278602-2	2001	Sustained NO production via the inducible enzyme, nitric-oxide synthase 2 (NOS2), requires extracellular arginine uptake.	Arginine	105-113	nitric oxide synthase 2, inducible	Mus musculus	75-79
11410419-0	2001	Alpha128 Arg--&gt;Ser (CGT--&gt;AGT) spectrin mutation associated with severe neonatal elliptopoikilocytosis in Spain.	Arginine	9-12	angiotensinogen	Homo sapiens	32-35
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	85-88	breast cancer anti-estrogen resistance 1	Mus musculus	131-134
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	97-100	breast cancer anti-estrogen resistance 1	Mus musculus	131-134
11279004-5	2001	Conversely, expression of a kinase-active form of Abl or reconstitution of abl-/- arg-/- cells with wild-type Abl prevents Crk-CAS coupling and inhibits cell migration.	Arginine	82-85	breast cancer anti-estrogen resistance 1	Mus musculus	127-130
11424234-3	2001	METHODS: Using an established cell line, we directly monitored NO release from GECs in response to various concentrations of D-glucose, D-mannitol, and L-arginine, an NO synthase (NOS) agonist.	Arginine	152-162	nitric oxide synthase 2	Homo sapiens	167-178
11316578-2	2001	Inducible nitric oxide synthase (Type 2 NOS or iNOS) converts arginine to citrulline, releasing NO.	Arginine	62-70	nitric oxide synthase 2, inducible	Mus musculus	0-31
11316578-2	2001	Inducible nitric oxide synthase (Type 2 NOS or iNOS) converts arginine to citrulline, releasing NO.	Arginine	62-70	nitric oxide synthase 2, inducible	Mus musculus	47-51
11306718-7	2001	In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg.	Arginine	46-49	interferon gamma	Homo sapiens	25-34
11306683-3	2001	This article explores the role of these residues in transport function by the development of cell lines in which arginines and lysines in RFC1 were replaced with leucine by site-directed mutagenesis.	Arginine	113-122	replication factor C (activator 1) 1	Mus musculus	138-142
11287558-6	2001	In two study subjects, arginine substitutions at position 306, associated with use of the chemokine coreceptor CXCR4, were preferentially found in CD4 lymphocytes.	Arginine	23-31	CD4 molecule	Homo sapiens	147-150
11306718-7	2001	In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg.	Arginine	202-205	interferon gamma	Homo sapiens	25-34
11278590-6	2001	In the x-ray structure, colipase has a hydrophobic surface positioned to bind substrate and a hydrophilic surface, lying opposite the hydrophobic surface, with two putative lipase-binding domains, Glu(45)/Asp(89) and Glu(64)/Arg(65).	Arginine	225-228	colipase	Homo sapiens	24-32
11426702-5	2001	K(M) and Vmax values, which were obtained for cow kappa-casein, showed that cow kappa-casein was a better susbstrate for trypsin than the others, suggesting that cow kappa-casein has a rich content of lysine, arginine, and aromatic amino acids by comparison with the others.	Arginine	209-217	casein kappa	Bos taurus	80-92
11426702-5	2001	K(M) and Vmax values, which were obtained for cow kappa-casein, showed that cow kappa-casein was a better susbstrate for trypsin than the others, suggesting that cow kappa-casein has a rich content of lysine, arginine, and aromatic amino acids by comparison with the others.	Arginine	209-217	casein kappa	Bos taurus	80-92
11278633-8	2001	These results demonstrate that the alpha(M)(Lys(245)-Arg(261)) segment, a site of the major sequence and structure difference among alpha(M)I-, alpha(X)I-, and alpha(L)I-domains, is responsible for recognition of a small segment of fibrinogen, gammaThr(383)-Gly(395), by serving as ligand binding site.	Arginine	53-56	fibrinogen beta chain	Homo sapiens	232-242
11278590-15	2001	These results demonstrate that the hydrophilic surface of colipase interacts with PTL in solution to form active colipase.PTL complexes, that bile salt micelles influence that binding, and that the proper interaction of colipase with PTL requires the Glu(64)/Arg(65) binding site.	Arginine	259-262	colipase	Homo sapiens	58-66
11290609-9	2001	Culture of TEL/ARG-transfected Ba/F3 cells with IL-3 completely prevented STI571-induced apoptosis in these cells, similar to what has been observed with BCR/ABL- or TEL/ABL-transformed cells.	Arginine	15-18	interleukin 3	Mus musculus	48-52
21044462-9	2001	The different biological effect between 172Leu and 172His shows that some p53 variants such as 172 Arg-&gt;Leu may act as wild-type p53.	Arginine	99-102	tumor protein p53	Homo sapiens	74-77
21044462-9	2001	The different biological effect between 172Leu and 172His shows that some p53 variants such as 172 Arg-&gt;Leu may act as wild-type p53.	Arginine	99-102	tumor protein p53	Homo sapiens	132-135
11288139-1	2001	Nitric oxide (NO) is a biologically active inorganic molecule produced when the semiessential amino acid l-arginine is converted to l-citrulline and NO via the enzyme nitric oxide synthase (NOS).	Arginine	105-115	nitric oxide synthase 2	Homo sapiens	167-188
11500636-2	2001	Aminopeptidase activities were studied by measuring the rate of hydrolysis of the artificial substrates Ala-, pGlu-, Pro-, Arg-, Asp- y Cis-2-naphthylamides (fluorimetrically detected at 412 rim with excitation at 345 nm).	Arginine	123-126	carboxypeptidase Q	Homo sapiens	0-14
11096085-10	2001	Additional hIK1/rSK2 chimeras defined the minimal region of hIK1 required to confer complete ATP sensitivity as including amino acids Arg(355)-Ala(413).	Arginine	134-137	potassium calcium-activated channel subfamily N member 2	Rattus norvegicus	16-20
11323020-3	2001	NO is produced through L-arginine pathway by three different isoforms of nitric oxide synthase (NOS), an inducible form that can be activated by cytokines such as tumor necrosis factor alpha (TNFalpha).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	73-94
11323020-3	2001	NO is produced through L-arginine pathway by three different isoforms of nitric oxide synthase (NOS), an inducible form that can be activated by cytokines such as tumor necrosis factor alpha (TNFalpha).	Arginine	23-33	tumor necrosis factor	Homo sapiens	163-190
11312916-2	2001	The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif.	Arginine	67-70	fibrinogen beta chain	Homo sapiens	15-25
11312916-2	2001	The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif.	Arginine	67-70	fibrinogen beta chain	Homo sapiens	33-43
11118430-6	2001	These studies showed that cationic residues, Lys(7), Lys(11), and Arg(34), constitute a part of the interfacial binding surface of hVPLA(2), which accounts for its moderate preference for anionic membranes.	Arginine	66-69	phospholipase A2 group V	Homo sapiens	131-139
11323020-3	2001	NO is produced through L-arginine pathway by three different isoforms of nitric oxide synthase (NOS), an inducible form that can be activated by cytokines such as tumor necrosis factor alpha (TNFalpha).	Arginine	23-33	tumor necrosis factor	Homo sapiens	192-200
11308397-7	2001	RESULTS: Mutation analysis of all 3 collagen IX genes resulted in identification of an Arg103-->Trp (arginine-->tryptophan) substitution in the alpha3 chain (Trp3 allele).	Arginine	101-109	immunoglobulin kappa variable 2D-28	Homo sapiens	144-150
11096085-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 2	Rattus norvegicus	101-105
11152681-5	2001	Myelin basic protein methylated by PRMT5 contained monomethylated and dimethylated arginine residues.	Arginine	83-91	protein arginine methyltransferase 5	Homo sapiens	35-40
11247830-5	2001	Infusion of N(G)-nitro-L-arginine methyl ester (L-NAME) into the renal medulla unmasked ANG II sensitivity in WKY rats while L-arginine given into the renal medulla abolished the responses to ANG II in SHR.	Arginine	23-33	angiotensinogen	Rattus norvegicus	88-94
11256955-2	2001	The protein is expressed predominantly in heart and binds to PtdIns3P specifically, even though the FYVE domains in TAFF1 lacks the first Arg of the consensus sequence R(K/R)HHCR, critical for the PtdIns3P binding of other FYVE domains identified so far.	Arginine	138-141	zinc finger FYVE-type containing 1	Homo sapiens	116-121
11337906-0	2001	Characterization of an apolipoprotein E3 variant (Arg 145--&gt;His) associated with mild hypertriglyceridemia.	Arginine	50-53	apolipoprotein E	Homo sapiens	23-40
11337906-1	2001	In a proband (21-yr-old female), we previously identified an apolipoprotein (apo) E variant, apoE3 (Arg 145--&gt;His), with an isoelectric point midway between apoE3 and apoE2.	Arginine	100-103	apolipoprotein E	Homo sapiens	61-83
11337906-1	2001	In a proband (21-yr-old female), we previously identified an apolipoprotein (apo) E variant, apoE3 (Arg 145--&gt;His), with an isoelectric point midway between apoE3 and apoE2.	Arginine	100-103	apolipoprotein E	Homo sapiens	93-98
11256955-3	2001	The first Arg is replaced by a Thr and Ser in the N-terminal and C-terminal FYVE domains of TAFF1 respectively.	Arginine	10-13	zinc finger FYVE-type containing 1	Homo sapiens	92-97
11309260-7	2001	These results suggest that the human NOS isozymes have different-sized cavities in the binding site near the position to which the C-terminal of L-arginine binds, and the cavity of iNOS is hydrophobic.	Arginine	145-155	nitric oxide synthase 2	Homo sapiens	181-185
11274268-0	2001	Supplementation with a low dose of L-arginine reduces blood pressure and endothelin-1 production in hypertensive uraemic rats.	Arginine	35-45	endothelin 1	Rattus norvegicus	73-85
11297586-0	2001	Relationship between the morphological evaluation of the pituitary and the growth hormone (GH) response to GH-releasing hormone Plus arginine in children and adults with congenital hypopituitarism.	Arginine	133-141	growth hormone 1	Homo sapiens	75-89
11355300-4	2001	We also observed a known polymorphism at hBUBR1 codon 349 (CAA/CGA, Gln/Arg), with an allelic frequency of 0.75 for Gln and 0.25 for Arg, which is similar to that among healthy Caucasian individuals (0.73 vs 0.27).	Arginine	133-136	chromogranin A	Homo sapiens	63-66
11293168-2	2001	Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing revealed a single nucleotide substitution on exon 7 of the human androgen receptor (hAR) gene, resulting in a change of CGA (arginine) to CAA (glutamine) in codon 831.	Arginine	210-218	androgen receptor	Homo sapiens	150-167
11293168-2	2001	Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing revealed a single nucleotide substitution on exon 7 of the human androgen receptor (hAR) gene, resulting in a change of CGA (arginine) to CAA (glutamine) in codon 831.	Arginine	210-218	chromogranin A	Homo sapiens	205-208
11254692-7	2001	The KIR3DH molecules have three Ig domains, transmembrane domains homologous to KIR2DL4 molecules that contain an arginine, and short cytoplasmic domains.	Arginine	114-122	killer cell immunoglobulin-like receptor, 3 domains, hybrid	Macaca mulatta	4-10
11274268-4	2001	We investigated whether supplementation with L-arginine, the natural precursor of NO, improves NO synthesis in uraemic rats with reduced renal mass and modulates vascular and renal ET-1 production as well as blood pressure and renal failure progression.	Arginine	45-55	endothelin 1	Rattus norvegicus	181-185
11274268-13	2001	Treatment with 0.1% L-arginine significantly reduced proteinuria and urinary ir-ET-1 excretion (P&lt;0.05) as well as ir-ET-1 level in glomeruli (P&lt;0.01) and in thoracic aorta (P&lt;0.05).	Arginine	20-30	endothelin 1	Rattus norvegicus	80-84
11274268-13	2001	Treatment with 0.1% L-arginine significantly reduced proteinuria and urinary ir-ET-1 excretion (P&lt;0.05) as well as ir-ET-1 level in glomeruli (P&lt;0.01) and in thoracic aorta (P&lt;0.05).	Arginine	20-30	endothelin 1	Rattus norvegicus	121-125
11292368-0	2001	Caveolar localization of arginine regeneration enzymes, argininosuccinate synthase, and lyase, with endothelial nitric oxide synthase.	Arginine	25-33	nitric oxide synthase 3	Homo sapiens	100-133
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Arginine	131-139	nitric oxide synthase 2, inducible	Mus musculus	245-249
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Arginine	374-382	toll-like receptor 4	Mus musculus	15-18
11292368-3	2001	In this study, we demonstrate that exogenous citrulline was as effective as exogenous arginine in stimulating nitric oxide production and that citrulline in the presence of excess intracellular and extracellular arginine further enhanced bradykinin stimulated endothelial nitric oxide production.	Arginine	212-220	kininogen 1	Homo sapiens	238-248
11274268-15	2001	In contrast, supplementation with 1% L-arginine had no effect on systolic blood pressure in uraemic rats, but exacerbated proteinuria and urinary ir-ET-1 excretion and increased serum urea (P&lt;0.05) were observed.	Arginine	37-47	endothelin 1	Rattus norvegicus	149-153
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Arginine	374-382	toll-like receptor 4	Mus musculus	123-126
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Arginine	374-382	toll-like receptor 4	Mus musculus	123-126
11292369-5	2001	A stimulatory effect of LPS was also found on NOS activity in the cerebellum, where a very small stimulation may have also been caused by arginine feeding.	Arginine	138-146	toll-like receptor 4	Mus musculus	24-27
11240860-2	2001	The aim of this study was to evaluate the participation of Arg- and Lys-gingipain activities of P. gingivalis in the acquisition of iron from human transferrin and its subsequent utilization in growth.	Arginine	59-62	transferrin	Homo sapiens	148-159
11292369-6	2001	These findings indicate that LPS stimulates NOS expression/activity both in the cerebellum and in the liver and suggest a complex pattern of modulation of iNOS by arginine, with NO being first produced in excess and then downregulating iNOS expression.	Arginine	163-171	toll-like receptor 4	Mus musculus	29-32
11292369-6	2001	These findings indicate that LPS stimulates NOS expression/activity both in the cerebellum and in the liver and suggest a complex pattern of modulation of iNOS by arginine, with NO being first produced in excess and then downregulating iNOS expression.	Arginine	163-171	nitric oxide synthase 2, inducible	Mus musculus	155-159
11240860-7	2001	The lack of both Arg- and Lys-gingipain activities (mutants M1 and KDP128) was associated with an absence of degradation of transferrin and the incapacity of bacteria to grow in the presence of transferrin as the sole source of iron.	Arginine	17-20	transferrin	Homo sapiens	124-135
11240860-7	2001	The lack of both Arg- and Lys-gingipain activities (mutants M1 and KDP128) was associated with an absence of degradation of transferrin and the incapacity of bacteria to grow in the presence of transferrin as the sole source of iron.	Arginine	17-20	transferrin	Homo sapiens	194-205
11257227-0	2001	Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.	Arginine	0-8	interferon alpha 1	Homo sapiens	40-48
11359614-5	2001	DNA sequence analysis of the pbs1-2 allele showed it to be a missense mutation that caused a glycine to arginine substitution in the activation segment of PBS1, a region known to regulate substrate binding and catalytic activity in many protein kinases.	Arginine	104-112	Protein kinase superfamily protein	Arabidopsis thaliana	29-33
11359614-5	2001	DNA sequence analysis of the pbs1-2 allele showed it to be a missense mutation that caused a glycine to arginine substitution in the activation segment of PBS1, a region known to regulate substrate binding and catalytic activity in many protein kinases.	Arginine	104-112	Protein kinase superfamily protein	Arabidopsis thaliana	155-159
11380955-3	2001	DRB1*1139 is identical to DRB1*11011 except at codon 51 (ACG--&gt;AGG) changing the encoded Threonine to Arginine.	Arginine	105-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
11380955-3	2001	DRB1*1139 is identical to DRB1*11011 except at codon 51 (ACG--&gt;AGG) changing the encoded Threonine to Arginine.	Arginine	105-113	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Arginine	22-25	cannabinoid receptor 1	Homo sapiens	81-87
11396735-0	2001	Arginine form of p21 gene codon 31 is less prominent in patients with calcium oxalate stone.	Arginine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-20
11396735-8	2001	Individuals possessing arginine form of p21 codon 31 have less risk of developing calcium stone disease.	Arginine	23-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-43
11259085-2	2001	A p53 Pro/Arg polymorphism at exon 4 codon 72, has been suggested to be involved in susceptibility to cancers as well.	Arginine	10-13	tumor protein p53	Homo sapiens	2-5
11257227-3	2001	Here we demonstrate arginine methylation of STAT1 by the protein arginine methyl-transferase PRMT1 as a novel requirement for IFNalpha/beta-induced transcription.	Arginine	20-28	interferon alpha 1	Homo sapiens	126-134
11258877-3	2001	In redox buffer containing L-arginine, the yield of native PIP from fully reduced/denatured PIP can reach 85%.	Arginine	27-37	prolactin induced protein	Homo sapiens	59-62
11258877-3	2001	In redox buffer containing L-arginine, the yield of native PIP from fully reduced/denatured PIP can reach 85%.	Arginine	27-37	prolactin induced protein	Homo sapiens	92-95
11328364-1	2001	BACKGROUND: Nitric oxide (NO) is synthesized enzymatically from L-arginine by NO synthase, which is measured by inducible NO synthase (iNOS).	Arginine	64-74	nitric oxide synthase 2	Homo sapiens	135-139
11104775-7	2001	The most important residue in the KIM sequence of MKP3 is Arg(65), which probably interacts with Asp(319) in ERK2.	Arginine	58-61	mitogen-activated protein kinase 1	Homo sapiens	109-113
11238294-9	2001	However, these subjects had a mutation of the apo B-100 gene (Arg(3500)--&gt;Trp).	Arginine	62-65	apolipoprotein B	Homo sapiens	46-55
11181409-3	2001	Stimulation decreased progressively at concentrations &gt;10(-10) M to a value of 0.96 +/- 0.1-fold at 10(-7) M. In the presence of additional L-arginine, the substrate for NO synthesis, the stimulatory effect of ANG II (10(-11) M) was lost.	Arginine	143-153	angiotensinogen	Rattus norvegicus	213-219
11181800-6	2001	This study examined whether apoE2 Sendai (Arg(145) Pro) was functionally different from type III HLP-producing apoE variants by expressing apoE3, apoE2 (Arg(158) Cys), apoE1 (Arg(146) Glu), a dominant apoE variant, and apoE2 Sendai (Arg(145) Pro) in the baculovirus system.	Arginine	42-45	apolipoprotein E	Homo sapiens	28-32
11238514-6	2001	In IGT, insulin levels were significantly lower during the first phase (144 +/- 20 vs. 397 +/- 119 pmol/L; P = 0.02), at the end of the GLP infusion (2142 +/- 350 vs. 5430 +/- 1091 pmol/L; P: = 0.002), and in response to arginine (3983 +/- 375 vs. 8663 +/- 1430 pmol/L; P = 0.005).	Arginine	221-229	insulin	Homo sapiens	8-15
11238514-8	2001	In subjects with IGT, the PI/I ratio decreased significantly after GLP-1 priming (1.7 +/- 0.2%; P = 0.02) and after arginine given during GLP-1 (1.4 +/- 0.2%; P = 0.007) and was not significantly different from those values in NGT (1.3 +/- 0.2% and 1.3 +/- 0.2%, respectively; both P = NS).	Arginine	116-124	glucagon	Homo sapiens	138-143
11262081-2	2001	The binding of the cosalanes to CD4 is proposed to involve ionic interactions of the negatively charged carboxylates of the ligands with positively charged arginine and lysine amino acid side chains of the protein.	Arginine	156-164	CD4 molecule	Homo sapiens	32-35
11902565-1	2001	Nitric oxide (NO) is a short-lived molecule required for many physiological functions, produced from L-arginine by NO synthases (NOS).	Arginine	101-111	nitric oxide synthase 2	Homo sapiens	115-127
11179504-10	2001	In conclusion, the increased frequency of WAF1 polymorphism in the patients studied implied that codon 31 Arg allele of the WAF1 gene may be associated with a tendency to develop cervical carcinoma.	Arginine	106-109	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-46
11179504-10	2001	In conclusion, the increased frequency of WAF1 polymorphism in the patients studied implied that codon 31 Arg allele of the WAF1 gene may be associated with a tendency to develop cervical carcinoma.	Arginine	106-109	cyclin dependent kinase inhibitor 1A	Homo sapiens	124-128
11181800-11	2001	ApoE2 Sendai (Arg(145) Pro) represents the only known mutation within the heparin-binding domain of apoE (residues 142 through 147), revealing diminished receptor binding and almost normal heparin binding.	Arginine	14-17	apolipoprotein E	Homo sapiens	0-5
11181800-11	2001	ApoE2 Sendai (Arg(145) Pro) represents the only known mutation within the heparin-binding domain of apoE (residues 142 through 147), revealing diminished receptor binding and almost normal heparin binding.	Arginine	14-17	apolipoprotein E	Homo sapiens	100-104
11172921-2	2001	Changes in arginine metabolism during infection are not limited to effects of iNOS but can also involve arginases, which can modulate NO synthesis and produce ornithine for the generation of polyamines and proline.	Arginine	11-19	nitric oxide synthase 2	Homo sapiens	78-82
11231463-15	2001	Arginase and NOS 2 may compete for available arginine as a substrate, thereby limiting later NO production in favor of sustained ornithine synthesis.	Arginine	45-53	nitric oxide synthase 2	Sus scrofa	13-18
22432124-2	2001	The arginine derivative N(omega)-L-arginine methylester (L-NAME), which non-specifically inhibits NO formation induced by all constitutive forms of NO synthase (NOS), significantly augmented the effect of IL-1P,but blockade of CO formation with metalloporphyrins was without effect.	Arginine	4-12	nitric oxide synthase 2	Homo sapiens	148-159
11236905-1	2001	Arginine is the sole substrate for nitric oxide (NO) synthesis by NO synthases (NOS) and promotes the proliferation and maturation of human T-cells.	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	66-78
11222476-10	2001	CONCLUSIONS: These results demonstrate that TGF-beta(1) stimulates polyamine and L-proline synthesis by inducing the genes that regulate the transport and metabolism of L-arginine.	Arginine	169-179	transforming growth factor beta 1	Homo sapiens	44-55
11239195-1	2001	BACKGROUND AND PURPOSE: Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS) encoded by the NOS 3 gene on chromosome 7.	Arginine	62-72	nitric oxide synthase 3	Homo sapiens	101-105
11239195-1	2001	BACKGROUND AND PURPOSE: Endothelium-derived NO is formed from L-arginine by endothelial NO synthase (eNOS) encoded by the NOS 3 gene on chromosome 7.	Arginine	62-72	nitric oxide synthase 3	Homo sapiens	122-127
11222476-0	2001	Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis.	Arginine	46-56	transforming growth factor beta 1	Homo sapiens	0-34
11222476-2	2001	Because L-arginine is metabolized to growth-stimulatory polyamines and to the essential collagen precursor L-proline, we examined whether TGF-beta(1) regulates the transcellular transport and metabolism of L-arginine by VSMCs.	Arginine	206-216	transforming growth factor beta 1	Homo sapiens	138-149
11222476-3	2001	METHODS AND RESULTS: TGF-beta(1) increased L-arginine uptake, and this was associated with a selective increase in cationic amino acid transporter-1 (CAT-1) mRNA.	Arginine	43-53	transforming growth factor beta 1	Homo sapiens	21-32
11222476-4	2001	In addition, TGF-beta(1) stimulated L-arginine metabolism by inducing arginase I mRNA and arginase activity.	Arginine	36-46	transforming growth factor beta 1	Homo sapiens	13-24
11226433-0	2001	Different susceptibility to oxidation of proline and arginine residues of apolipoprotein B-100 among subspecies of low density lipoproteins.	Arginine	53-61	apolipoprotein B	Homo sapiens	74-94
11226433-1	2001	gamma-Glutamyl semialdehyde is a primary oxidation product of apolipoprotein (apo) B-100 proline (Pro) and arginine (Arg) side chain residues.	Arginine	117-120	apolipoprotein B	Homo sapiens	62-88
11222476-12	2001	The ability of TGF-beta(1) to upregulate L-arginine transport and direct its metabolism to polyamines and L-proline may contribute to arterial remodeling at sites of vascular damage.	Arginine	41-51	transforming growth factor beta 1	Homo sapiens	15-26
11160269-2	2001	We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS).	Arginine	77-85	nitric oxide synthase 2, inducible	Mus musculus	104-125
11159522-3	2001	In the heterozygous state, a cysteine-to-threonine (C --&gt; T) transversion was detected at nucleotide 4193 of the VWF gene of all patients and lead to the arginine (R)522C substitution in the A1 loop of vWF mature subunit (R1315C in the preprovWF).	Arginine	157-165	von Willebrand factor	Homo sapiens	116-119
11159522-3	2001	In the heterozygous state, a cysteine-to-threonine (C --&gt; T) transversion was detected at nucleotide 4193 of the VWF gene of all patients and lead to the arginine (R)522C substitution in the A1 loop of vWF mature subunit (R1315C in the preprovWF).	Arginine	157-165	von Willebrand factor	Homo sapiens	205-208
11222476-6	2001	TGF-beta(1) markedly increased the capacity of VSMCs to generate the polyamine putrescine and L-proline from extracellular L-arginine.	Arginine	123-133	transforming growth factor beta 1	Homo sapiens	0-11
11160269-2	2001	We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS).	Arginine	77-85	interleukin 13	Mus musculus	27-32
11160269-2	2001	We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS).	Arginine	77-85	nitric oxide synthase 2, inducible	Mus musculus	127-131
11170995-4	2001	Patients in the 2 HIV groups also were found to have significantly reduced C5a-induced chemotactic responses and significantly elevated peripheral levels of C5a des Arg, compared with the HD and TB groups.	Arginine	165-168	complement C5a receptor 1	Homo sapiens	157-160
11342002-6	2001	Furthermore, this increase was observed at submaximal extracellular arginine concentrations, suggesting that apoE altered arginine (substrate) availability.	Arginine	122-130	apolipoprotein E	Mus musculus	109-113
11257265-3	2001	Two frequent mutations at the paraoxonase gene locus (PON1) underlie the leucine (Leu allele) --&gt; methionine (Met allele) and the glutamine(Gln allele) --&gt; arginine(Arg allele) aminoacid substitutions at residues 55 and 192, respectively.	Arginine	162-170	paraoxonase 1	Homo sapiens	54-58
11257265-3	2001	Two frequent mutations at the paraoxonase gene locus (PON1) underlie the leucine (Leu allele) --&gt; methionine (Met allele) and the glutamine(Gln allele) --&gt; arginine(Arg allele) aminoacid substitutions at residues 55 and 192, respectively.	Arginine	171-174	paraoxonase 1	Homo sapiens	54-58
11342002-0	2001	Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport.	Arginine	88-96	apolipoprotein E	Mus musculus	0-16
21171437-3	2001	(2) Pretreatment with L-Arg or ANP could effectively inhibit the above biological actions induced by ET-1.	Arginine	22-27	endothelin 1	Rattus norvegicus	101-105
11342002-6	2001	Furthermore, this increase was observed at submaximal extracellular arginine concentrations, suggesting that apoE altered arginine (substrate) availability.	Arginine	68-76	apolipoprotein E	Mus musculus	109-113
11342002-7	2001	Examination of [(3)H]arginine uptake across the cell membrane demonstrated that arginine uptake was increased by PIC but further increased by PIC plus apoE.	Arginine	80-88	apolipoprotein E	Mus musculus	151-155
11342002-8	2001	Treatment of RAW cells with apoE was associated with an increased apparent V(max) and decreased affinity for arginine as well as a switch in the induction of mRNA for subtypes of cationic amino acid transporters (CAT).	Arginine	109-117	apolipoprotein E	Mus musculus	28-32
11342002-10	2001	Regulation of arginine availability is a novel action of apoE on the regulation of macrophage function and the immune response.	Arginine	14-22	apolipoprotein E	Mus musculus	57-61
11221839-1	2001	Macrophages use L-arginine to synthesize nitric oxide (NO) and polyamines through the inducible NO synthase (iNOS) and arginase, respectively.	Arginine	16-26	nitric oxide synthase 2	Rattus norvegicus	86-107
11221839-1	2001	Macrophages use L-arginine to synthesize nitric oxide (NO) and polyamines through the inducible NO synthase (iNOS) and arginase, respectively.	Arginine	16-26	nitric oxide synthase 2	Rattus norvegicus	109-113
11221839-12	2001	It appears that L-arginine metabolism through the arginase and iNOS pathways in macrophages can have very different influences on the growth of nearby tumor cells depending on which pathway is prevailing.	Arginine	16-26	nitric oxide synthase 2	Rattus norvegicus	63-67
11273008-3	2001	The first tumor contained 2 p53 mutations, in codon 213 (CGA--&gt;TGA, Arg--&gt;stop) and codon 306 (CGA--&gt;TGA, Arg--&gt;stop), further, 1 missense PTEN mutation (codon 257, TTC--&gt;TTA, Phe--&gt;Leu) and a silent PTEN mutation (codon 154, TTC--&gt;TTT, Phe--&gt;Phe).	Arginine	71-74	tumor protein p53	Homo sapiens	28-31
11273008-4	2001	The second glioblastoma also contained multiple, but different mutations: p53 mutations in codons 158 (CGC--&gt;CAC, Arg--&gt;His) and 273 (CGT--&gt;TGT, Arg--&gt;Cys), and a PTEN mutation in codon 233 (CGA--&gt;TGA, Arg--&gt;Stop).	Arginine	117-120	tumor protein p53	Homo sapiens	74-77
11273008-4	2001	The second glioblastoma also contained multiple, but different mutations: p53 mutations in codons 158 (CGC--&gt;CAC, Arg--&gt;His) and 273 (CGT--&gt;TGT, Arg--&gt;Cys), and a PTEN mutation in codon 233 (CGA--&gt;TGA, Arg--&gt;Stop).	Arginine	154-157	tumor protein p53	Homo sapiens	74-77
11273008-4	2001	The second glioblastoma also contained multiple, but different mutations: p53 mutations in codons 158 (CGC--&gt;CAC, Arg--&gt;His) and 273 (CGT--&gt;TGT, Arg--&gt;Cys), and a PTEN mutation in codon 233 (CGA--&gt;TGA, Arg--&gt;Stop).	Arginine	154-157	tumor protein p53	Homo sapiens	74-77
11210869-13	2001	CONCLUSIONS: From the results of this study it is suggested that nitric oxide (NO) produced by iNOS and eNOS using L-arginine may increase CBF in the healthy sinus mucosa and that NO may have a regulatory function in ciliary motility in the human sinus mucosa.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	95-99
21171437-4	2001	CONCLUSION: Intrarenal arterial injection of ET-1 can markedly induce the increase in RANA, an effect which is abolished by L-arg or ANP administered by the same route.	Arginine	124-129	endothelin 1	Rattus norvegicus	45-49
11212257-2	2001	It was suggested that HPV 16 E6 variants and the p53 codon 72 arginine polymorphism could be progression markers.	Arginine	62-70	tumor protein p53	Homo sapiens	49-52
11798852-7	2001	It changed the codon CGA for Arginine to a terminator codon TGA and causes retinitis pigmentosa in the two families.	Arginine	29-37	chromogranin A	Homo sapiens	21-24
11162796-9	2001	(iii) The EBNA-LP mutant with the arginine to alanine substitutions in NMTS was no longer localized not only to the nuclear matrix but also to the nucleus.	Arginine	34-42	EBNA-LP	Human gammaherpesvirus 4	10-17
11242979-3	2001	FDB is caused particularly by an arginine to glutamine substitution at the codon for amino acid 3500 of the apo B-100.	Arginine	33-41	apolipoprotein B	Homo sapiens	108-117
11212257-3	2001	Indeed, it has been demonstrated that specific E6 variants and p53 arginine were both enriched in cancer.	Arginine	67-75	tumor protein p53	Homo sapiens	63-66
11212257-5	2001	Our aim was thus to investigate whether p53 arginine is important for cervical carcinogenesis by scaling up samples of the two European cohorts, the initial results of which were reported previously.	Arginine	44-52	tumor protein p53	Homo sapiens	40-43
11212257-7	2001	We found p53 arginine to be increased in cancer of both cohorts, consistent with our previous concept.	Arginine	13-21	tumor protein p53	Homo sapiens	9-12
11212257-8	2001	Although specific E6 genotypes increased gradually with the severity of the lesion, p53 arginine was enriched in cancer only.	Arginine	88-96	tumor protein p53	Homo sapiens	84-87
11212257-10	2001	It is concluded that p53 arginine is a risk factor for cervical cancer but probably acts independently of E6 variants.	Arginine	25-33	tumor protein p53	Homo sapiens	21-24
11342210-2	2001	Cleavage of the two A-fibrinopeptides (FPA, Aalpha1-16) from normal Aalpha chains with arginine at position 16 (RFPA) by thrombin or the venom enzyme atroxin transforms fibrinogen into self-aggregating fibrin monomers (alpha, Bbeta, gamma)(2).	Arginine	87-95	coagulation factor II, thrombin	Homo sapiens	121-129
11180458-7	2001	The activities of arginine (Can1p), proline (Put4p) and general amino acid permease (Gap1p) are decreased more than 20-fold.	Arginine	18-26	amino acid permease GAP1	Saccharomyces cerevisiae S288C	85-90
11669337-10	2001	A common polymorphism in p53 at codon 72 (arginine/proline) was found in 6/8 of the patients.	Arginine	42-50	tumor protein p53	Homo sapiens	25-28
11213361-1	2001	Nitric oxide (NO) is a multifunctional messenger molecule generated from L-arginine by a family of enzymes, including nitric oxide synthase (NOS).	Arginine	73-83	nitric oxide synthase 2	Homo sapiens	118-139
11257802-0	2001	Inhibition of platelet aggregation of a mutant proinsulin molecule engineered by introduction of a native Arg-Gly-Asp sequence.	Arginine	106-109	insulin	Homo sapiens	47-57
11665817-0	2001	L-arginine stimulates insulin secretion from the pancreas of normal and diabetic rats.	Arginine	0-10	insulin	Homo sapiens	22-29
11665817-4	2001	L-arginine evoked large increases in insulin secretion from the pancreas of diabetic rat.	Arginine	0-10	insulin	Homo sapiens	37-44
11665817-6	2001	In conclusion, L-arginine, a nitric oxide donor stimulates insulin secretion from the pancreas of diabetic rats.	Arginine	15-25	insulin	Homo sapiens	59-66
11174479-1	2001	OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position.	Arginine	151-159	tumor protein p53	Homo sapiens	119-122
11174479-1	2001	OBJECTIVE: It has recently been suggested that white women who are homozygous for the allele of the gene for wild-type p53 protein (TP53) that encodes arginine at position 72 are more susceptible to human papillomavirus-associated cervical carcinoma than are women who are heterozygous for this polymorphism and women who are homozygous for the allele that encodes proline at that position.	Arginine	151-159	tumor protein p53	Homo sapiens	132-136
11257802-2	2001	The constructed Arg-Gly-Asp (RGD)-proinsulin gene was cloned into a temperature-inducible vector pBV220 and expressed in Escherichia coli.	Arginine	16-19	insulin	Homo sapiens	34-44
11145944-9	2001	Reducing positive charges on lysine and arginine residues on HDL+E eliminated biglycan binding, suggesting an ionic interaction.	Arginine	40-48	biglycan	Homo sapiens	78-86
12016330-5	2001	Of particular significance are the halogenation reactions mediated by myeloperoxidase that can modify key amino acids such as arginine and polyphenolics such as genistein.	Arginine	126-134	myeloperoxidase	Homo sapiens	70-85
11842279-5	2001	In a Turkish proband, an arginine (CGT) to cysteine (TGT) substitution at amino acid position 116 was identified.	Arginine	25-33	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	53-56
11898853-5	2001	Inflammatory cytokines induce the expression of inducible NO synthase (iNOS) and direct the metabolism of L-arginine to the antiproliferative gas, NO.	Arginine	106-116	nitric oxide synthase 2	Homo sapiens	48-69
11898853-5	2001	Inflammatory cytokines induce the expression of inducible NO synthase (iNOS) and direct the metabolism of L-arginine to the antiproliferative gas, NO.	Arginine	106-116	nitric oxide synthase 2	Homo sapiens	71-75
11811790-2	2001	We have mutated residues A54 and L55 of IGF-II in the second A domain helix to arginine (found in the corresponding positions of IGF-I) and measured IGF2R binding.	Arginine	79-87	insulin like growth factor 1	Homo sapiens	40-45
11336572-5	2001	The generation of NO from L-arginine is catalysed by nitric oxide synthase (NOS).	Arginine	26-36	nitric oxide synthase 2	Homo sapiens	53-74
11408744-0	2001	Fibrinogen kaiserslautern III: a new case of congenital dysfibrinogenemia with aalpha 16 arg--&gt;cys substitution.	Arginine	89-92	fibrinogen beta chain	Homo sapiens	0-10
11408744-4	2001	DNA sequencing revealed a heterozygous C to T point mutation in position 1202 of exon 2 of the Aalpha chain, resulting in the substitution of Arg--&gt;Cys at position 16, the thrombin cleavage site.	Arginine	142-145	coagulation factor II, thrombin	Homo sapiens	175-183
11409295-6	2001	In contrast, in the subgroup of type 2 diabetic patients the PON1 192 Arg allele conferred about twice the risk of cerebrovascular stenosis compared to those homozygous for the Gln allele (Odds ratio 2.00, 95%-CI 0.92-4.38).	Arginine	70-73	paraoxonase 1	Homo sapiens	61-65
11409295-8	2001	The observed interaction with type 2 diabetes, however, is supporting the hypothesis that the effect of the PON1 192 Arg allele on atherosclerosis is modulated by other risk factors like diabetes.	Arginine	117-120	paraoxonase 1	Homo sapiens	108-112
11305941-3	2001	Thus, the arginine repressor is different from two other universal transcription factors - HrcA, whose recognition signal is very strongly conserved both within and between genomes, and LexA/DinR, whose signal is strongly conserved within, but not between, genomes.	Arginine	10-18	DNA repair system	Escherichia coli	186-190
28452439-7	2001	In the future, thrombin inhibitors such as recombinant hirudin and the arginine derivative argatroban will probably be the agents most widely used to prevent thromboembolic complications.	Arginine	71-79	coagulation factor II, thrombin	Homo sapiens	15-23
11920243-9	2001	Our results also demonstrate that Arg 1715 is not essential in the function but it is necessary for maintaining the conformation recognized by MoAb 9 specific for the GPIIb/IIIa-binding domain of VWF.	Arginine	34-37	von Willebrand factor	Homo sapiens	196-199
11231970-7	2001	The result showed that the proband had a heterozygous nonsense mutation in exon 7 of the CaSR gene at codon 648 (CGA--&gt;TGA/Arg--&gt;Ter).	Arginine	126-129	calcium sensing receptor	Homo sapiens	89-93
11500931-7	2001	Previous study demonstrated that decrease of NO production by L-arginine analogs effectively stimulated LPS-induced iNOS gene expression, and proposed that stimulatory effects on iNOS protein by NOS inhibitors might be harmful in treating sepsis.	Arginine	62-72	nitric oxide synthase 2, inducible	Mus musculus	116-120
11500931-7	2001	Previous study demonstrated that decrease of NO production by L-arginine analogs effectively stimulated LPS-induced iNOS gene expression, and proposed that stimulatory effects on iNOS protein by NOS inhibitors might be harmful in treating sepsis.	Arginine	62-72	nitric oxide synthase 2, inducible	Mus musculus	179-183
11500931-10	2001	These results indicated that combinatorial treatment of L-arginine analogs and flavonoid derivates, such as quercetin pentaacetate, effectively inhibited LPS-induced NO and PGE2 productions, at the same time, inhibited enhanced expressions of iNOS and COX-2 genes.	Arginine	56-66	nitric oxide synthase 2, inducible	Mus musculus	243-247
11255264-4	2001	We set out a case-control study to determine the risk of squamous cell carcinoma of the skin in individuals with the p53 codon 72 arginine genotype in order to establish the possible need for screening.	Arginine	130-138	tumor protein p53	Homo sapiens	117-120
11150026-2	2001	A C-to-T transition at nucleotide 4120 in exon 28 of the VWF gene was found; this mutation introduces a cysteine at the codon for Arg 611 of mature VWF.	Arginine	130-133	von Willebrand factor	Homo sapiens	57-60
11150026-2	2001	A C-to-T transition at nucleotide 4120 in exon 28 of the VWF gene was found; this mutation introduces a cysteine at the codon for Arg 611 of mature VWF.	Arginine	130-133	von Willebrand factor	Homo sapiens	148-151
21340840-7	2001	We have identified a missense mutation in the p53 gene in the 2774 ovarian cancer cell line that converts an arginine residue in the DNA binding region of the protein to a histidine residue (6).	Arginine	109-117	tumor protein p53	Homo sapiens	46-49
11160363-0	2001	Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase.	Arginine	6-14	apolipoprotein A1	Homo sapiens	27-45
11160363-3	2001	We observed that the hydrophobic/hydrophilic interface of helix 143;-164 contains a cluster of three strictly conserved arginine residues (R149, R153, and R160), and that these residues create the only significant positive electrostatic potential around apoA-I.	Arginine	120-128	apolipoprotein A1	Homo sapiens	254-260
11190986-13	2001	L-Arginine modestly increased IL-2 production and had pronounced effects on its disappearance from the culture media (p &lt; .0001).	Arginine	0-10	interleukin 2	Homo sapiens	30-34
11190986-16	2001	L-Arginine may increase cellular proliferation by increasing specific receptor expression and the utilization of interleukin-2.	Arginine	0-10	interleukin 2	Homo sapiens	113-126
11277076-7	2001	Pro--&gt;Arg substitutions equivalent the Pro253Arg/FGFR2 mutation occur in both FGFR1 and FGFR3, and are also associated with craniosynostosis.	Arginine	9-12	fibroblast growth factor receptor 1	Homo sapiens	81-86
11166077-2	2001	It is synthesized from the precursor L-arginine by the enzyme NO synthase (NOS), which transforms L-arginine into NO and citrulline.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	62-73
11166077-2	2001	It is synthesized from the precursor L-arginine by the enzyme NO synthase (NOS), which transforms L-arginine into NO and citrulline.	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	62-73
11587559-4	2001	The K(d) for arginine is approximately 0.5 microM for the tetrahydrobiopterin replete neuronal and inducible isoforms (nNOS and iNOS), while the endothelial isoform has a slightly higher K(d) (1.5 microM).	Arginine	13-21	nitric oxide synthase 2	Homo sapiens	128-132
11150170-11	2000	Thus, the key residues of gamma-MSH identified in this study include the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10) (but not Arg(7)), as important for MC3 selectivity over the MC4 and MC5 subtypes.	Arginine	129-132	proopiomelanocortin	Homo sapiens	26-35
12120187-8	2001	The herbal medicines and two components suppressed PAP mRNA expression and enhanced Mn-SOD and iNOS mRNA expression in arginine-treated AR4-2J cells.	Arginine	119-127	nitric oxide synthase 2	Rattus norvegicus	95-99
11172460-2	2001	NO is produced after oxidation of L-arginine by a family of nitric oxide synthase (NOS) enzymes.	Arginine	34-44	nitric oxide synthase 2	Homo sapiens	60-81
11007796-5	2000	Also, deletion of Glut1 residues 469-492 was without effect, but mutations involving serine 465 or arginine 468 yielded dominant-negative forms that inhibited glucose-dependent ERK activation.	Arginine	99-107	mitogen-activated protein kinase 1	Homo sapiens	177-180
11124973-3	2000	IL-1beta (10 ng/ml) treatment of rat striatal slices preloaded with (45)Ca(2+) elicited a delayed (30 min) and sustained increase (125-150%) in spontaneous (45)Ca(2+) release that was potentiated by l-arginine (300 microm) and counteracted by N-omega-nitro-l-arginine methyl ester (l-NAME) (1 and 3 mm).	Arginine	199-209	interleukin 1 beta	Rattus norvegicus	0-8
10960471-15	2000	), indicate that the most likely positioning of fMLF in the binding pocket of FPR is approximately parallel to the fifth transmembrane helix with the formamide group of fMLF hydrogen-bonded to both Asp-106 and Arg-201, the leucine side chain pointing toward the second transmembrane region, and the COOH-terminal carboxyl group of fMLF ion-paired with Arg-205.	Arginine	210-213	formyl peptide receptor 1	Homo sapiens	78-81
10960471-15	2000	), indicate that the most likely positioning of fMLF in the binding pocket of FPR is approximately parallel to the fifth transmembrane helix with the formamide group of fMLF hydrogen-bonded to both Asp-106 and Arg-201, the leucine side chain pointing toward the second transmembrane region, and the COOH-terminal carboxyl group of fMLF ion-paired with Arg-205.	Arginine	352-355	formyl peptide receptor 1	Homo sapiens	78-81
11113053-8	2000	The iNOS/L-arginine pathway mediated the latter activity, inasmuch as it was inhibited by treatment with N:(G)-monomethyl-L-arginine.	Arginine	11-19	nitric oxide synthase 2, inducible	Mus musculus	4-8
11156381-1	2000	Germ-line CDKN2A mutations are present in some kindreds with hereditary cutaneous melanoma, and in Sweden a founder mutation with an extra arginine in codon 113 (113insR) has been identified.	Arginine	139-147	cyclin dependent kinase inhibitor 2A	Homo sapiens	10-16
11156383-0	2000	Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus.	Arginine	35-43	tumor protein p53	Homo sapiens	44-47
11087229-4	2000	Adventitial NOS-2 activity largely accounted for 1) the relaxing effect of L-arginine in rings exposed to LPS in vivo, 2) generation of an "NO store" revealed by N-acetylcysteine-induced relaxation, and 3) formation of protein-bound dinitrosyl iron complexes in the medial layer of aortic rings exposed to LPS in vitro.	Arginine	75-85	nitric oxide synthase 2	Rattus norvegicus	12-17
11194055-2	2000	Nitric oxide is produced from the conversion of L-arginine to L-citrulline by inducible nitric oxide synthase (iNOS) and is a component of many cellular second messenger systems.	Arginine	48-58	nitric oxide synthase 2	Homo sapiens	78-109
11105092-4	2000	As with UCP1, the arginine reagent 2,3-butadione, but not N-ethylmaleimide or other hydrophobic SH reagents, prevented the inhibition of StUCP-mediated transport by ATP in isolated potato mitochondria or with reconstituted StUCP.	Arginine	18-26	Mitochondrial uncoupling protein 1-like	Solanum tuberosum	137-142
11105092-4	2000	As with UCP1, the arginine reagent 2,3-butadione, but not N-ethylmaleimide or other hydrophobic SH reagents, prevented the inhibition of StUCP-mediated transport by ATP in isolated potato mitochondria or with reconstituted StUCP.	Arginine	18-26	Mitochondrial uncoupling protein 1-like	Solanum tuberosum	223-228
11099479-5	2000	An analysis of the glucose- and arginine-induced electrical activity (several applications during 30 min) in terms of firing frequency and putative insulin release was done in control and in the presence of selective blockers of HERG channels: the firing frequency and the release increased by 32% and 77%, respectively.	Arginine	32-40	insulin	Homo sapiens	148-155
11076874-4	2000	METHODS: iNOS activity was assessed by the Griess reaction and the radiochemical L-arginine conversion assay.	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	9-13
11194055-2	2000	Nitric oxide is produced from the conversion of L-arginine to L-citrulline by inducible nitric oxide synthase (iNOS) and is a component of many cellular second messenger systems.	Arginine	48-58	nitric oxide synthase 2	Homo sapiens	111-115
11102465-2	2000	Another disorder of sarcolemmal excitability, hypokalemic periodic paralysis (HypoPP), which is usually caused by missense mutations of the S4 voltage sensors of the L-type Ca channel, was associated recently in one family with a mutation in the outermost arginine of the IIS4 voltage sensor (R669H) of hSkM1 (Bulman et al., 1999).	Arginine	256-264	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	78-84
11102465-3	2000	Intriguingly, an arginine-to-histidine mutation at the homologous position in the L-type Ca(2+) channel (R528H) is a common cause of HypoPP.	Arginine	17-25	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	133-139
10956659-2	2000	The serine protease thrombin proteolytically activates blood coagulation factor XIII by cleavage at residue Arg(37); factor XIII in turn cross-links fibrin molecules and gives mechanical stability to the blood clot.	Arginine	108-111	coagulation factor II, thrombin	Homo sapiens	20-28
11115897-7	2000	From the analysis of T-DNA insertion mutants, we demonstrate that the AtUBP1 and 2 subfamily helps confer resistance to the arginine analog canavanine.	Arginine	124-132	ubiquitin-specific protease 1	Arabidopsis thaliana	70-82
11097863-0	2000	Highly potent nociceptin analog containing the Arg-Lys triple repeat.	Arginine	47-50	prepronociceptin	Homo sapiens	14-24
11100732-3	2000	We previously found that the carboxy-terminal arginine of nascent Apg8 is removed by Apg4/Aut2 protease, leaving a glycine residue at the C terminus.	Arginine	46-54	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	66-70
11100732-3	2000	We previously found that the carboxy-terminal arginine of nascent Apg8 is removed by Apg4/Aut2 protease, leaving a glycine residue at the C terminus.	Arginine	46-54	cysteine protease ATG4	Saccharomyces cerevisiae S288C	85-89
11100732-3	2000	We previously found that the carboxy-terminal arginine of nascent Apg8 is removed by Apg4/Aut2 protease, leaving a glycine residue at the C terminus.	Arginine	46-54	cysteine protease ATG4	Saccharomyces cerevisiae S288C	90-94
11097863-1	2000	One of the structural characteristics of a neuropeptide nociceptin is the existence of Arg-Lys (RK) residues at positions 8-9 and 12-13; both RKs have been suggested to bind to the acidic amino acid cluster in the second extracellular loop of the seven transmembrane domain receptor ORL1.	Arginine	87-90	prepronociceptin	Homo sapiens	56-66
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Arginine	65-68	prepronociceptin	Homo sapiens	12-22
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Arginine	85-88	prepronociceptin	Homo sapiens	12-22
11097863-3	2000	Among these nociceptin analogs containing the RK triple repeat, [Arg-Lys(6-7)]- and [Arg-Lys(10-11)]nociceptins exhibited weak activities (6-9 and 60-90% of nociceptin, respectively) both in the receptor binding assay and in the [(35)S]GTPgammaS binding functional assay.	Arginine	85-88	prepronociceptin	Homo sapiens	100-110
11097863-5	2000	[Arg-Lys(14-15)]nociceptin was the first peptide analog found to be stronger than the parent nociceptin, and structure-activity studies have suggested that the incorporated Arg-Lys(14-15) interacts with either the receptor acidic amino acid cluster or the receptor aromatic amino acid residues.	Arginine	1-4	prepronociceptin	Homo sapiens	16-26
11097863-5	2000	[Arg-Lys(14-15)]nociceptin was the first peptide analog found to be stronger than the parent nociceptin, and structure-activity studies have suggested that the incorporated Arg-Lys(14-15) interacts with either the receptor acidic amino acid cluster or the receptor aromatic amino acid residues.	Arginine	1-4	prepronociceptin	Homo sapiens	93-103
11103816-4	2000	This arginine to leucine substitution was reported to alter the transactivational specificity of the AR protein.	Arginine	5-13	androgen receptor	Homo sapiens	101-103
10967110-4	2000	Of 39 binding proteins analyzed, only the Abl-related kinase Arg and the Cbl proto-oncogene product bound preferentially to the first two SH3 domains in tandem compared with the individual domains, consistent with a role in the developmental phenotype.	Arginine	61-64	ABL proto-oncogene 1, non-receptor tyrosine kinase S homeolog	Xenopus laevis	42-45
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Arginine	152-155	thromboxane A synthase 1	Homo sapiens	82-86
11062043-3	2000	Two nucleotide differences between the p13 from K30p (p13K30) and K34p (p13K34) result in a Trp-Arg substitution at amino acid 17 and the truncation of the 25 carboxyl-terminal residues of p13K34.	Arginine	96-99	keratin 34	Homo sapiens	66-70
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Arginine	165-168	thromboxane A synthase 1	Homo sapiens	13-17
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Arginine	165-168	thromboxane A synthase 1	Homo sapiens	82-86
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Arginine	165-168	thromboxane A synthase 1	Homo sapiens	13-17
11097184-7	2000	Aligning the TXAS sequence with the structurally known P450s, we proposed that in TXAS the A-ring propionate of the heme is hydrogen bonded to Asn-110, Arg-413, and Arg-478, whereas D-ring propionate is hydrogen bonded to Trp-133 and Arg-137.	Arginine	165-168	thromboxane A synthase 1	Homo sapiens	82-86
11078448-4	2000	IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine.	Arginine	115-123	interleukin 1 beta	Rattus norvegicus	0-8
11078448-4	2000	IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine.	Arginine	72-80	interleukin 1 beta	Rattus norvegicus	0-8
11126404-8	2000	In response to arginine, in contrast, proinsulin remained unchanged during the saline infusion (from 31 +/- 6 to 29 +/- 7 pmol/l, p = 0.50) but decreased during 5 h of lipid infusion from (21 +/- 3 to 15 +/- 2 pmol/l, p = 0.02).	Arginine	15-23	insulin	Homo sapiens	38-48
11126404-10	2000	CONCLUSION/INTERPRETATION: The statistically significantly lower PI:I ratio in response to arginine during experimentally increased concentrations of NEFA suggests that NEFA increase the conversion of proinsulin to insulin in humans in vivo.	Arginine	91-99	insulin	Homo sapiens	201-211
11126404-10	2000	CONCLUSION/INTERPRETATION: The statistically significantly lower PI:I ratio in response to arginine during experimentally increased concentrations of NEFA suggests that NEFA increase the conversion of proinsulin to insulin in humans in vivo.	Arginine	91-99	insulin	Homo sapiens	204-211
11053497-4	2000	Compelling evidence shows that enteral or parenteral administration of Arg reverses endothelial dysfunction associated with major cardiovascular risk factors (hypercholesterolemia, smoking, hypertension, diabetes, obesity/insulin resistance and aging) and ameliorates many common cardiovascular disorders (coronary and peripheral arterial disease, ischemia/reperfusion injury, and heart failure).	Arginine	71-74	insulin	Homo sapiens	222-229
11053497-3	2000	Arg exerts its vascular actions also through NO-independent effects, including membrane depolarization, syntheses of creatine, proline and polyamines, secretion of insulin, growth hormone, glucagon and prolactin, plasmin generation and fibrinogenolysis, superoxide scavenging and inhibition of leukocyte adhesion to nonendothelial matrix.	Arginine	0-3	insulin	Homo sapiens	164-171
11053497-3	2000	Arg exerts its vascular actions also through NO-independent effects, including membrane depolarization, syntheses of creatine, proline and polyamines, secretion of insulin, growth hormone, glucagon and prolactin, plasmin generation and fibrinogenolysis, superoxide scavenging and inhibition of leukocyte adhesion to nonendothelial matrix.	Arginine	0-3	growth hormone 1	Homo sapiens	173-187
11095426-0	2000	Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.	Arginine	71-74	insulin	Homo sapiens	0-7
11044227-4	2000	RESULTS: In perfused TALs, 0.5 mmol/L L-arginine (L-Arg), the substrate for NO synthase, significantly lowered J(HCO3)(-) from 35.4 +/- 4.6 to 23.2 +/- 2.9 pmol.	Arginine	38-48	Rho guanine nucleotide exchange factor 12	Rattus norvegicus	50-55
11092532-3	2000	NO is produced from arginine by nitric oxide synthase (NOS), an enzyme that exists in both constitutive and inducible (iNOS) forms.	Arginine	20-28	nitric oxide synthase 2, inducible	Mus musculus	119-123
11094174-0	2000	Rhodopsin gene codon 106 mutation (Gly-to-Arg) in a Japanese family with autosomal dominant retinitis pigmentosa.	Arginine	42-45	rhodopsin	Homo sapiens	0-9
11046131-6	2000	Sequence analysis of the rpb2-100 suppressor defined a cysteine replacement of the phylogenetically invariant arginine residue at position 512 (R512C), located within homology block D of Rpb2.	Arginine	110-118	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	25-29
11046131-6	2000	Sequence analysis of the rpb2-100 suppressor defined a cysteine replacement of the phylogenetically invariant arginine residue at position 512 (R512C), located within homology block D of Rpb2.	Arginine	110-118	DNA-directed RNA polymerase II core subunit RPB2	Saccharomyces cerevisiae S288C	187-191
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Arginine	77-85	tumor protein p53	Homo sapiens	100-103
11046142-6	2000	Simultaneous mutation of lysine residues 370, 372, 373, 381, 382, and 386 to arginine residues (6KR p53 mutant) generates a p53 molecule with potent transcriptional activity that is resistant to Mdm2-induced degradation and is refractory to Mdm2-mediated ubiquitination.	Arginine	77-85	tumor protein p53	Homo sapiens	124-127
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Arginine	104-107	coagulation factor II, thrombin	Homo sapiens	47-55
11053497-3	2000	Arg exerts its vascular actions also through NO-independent effects, including membrane depolarization, syntheses of creatine, proline and polyamines, secretion of insulin, growth hormone, glucagon and prolactin, plasmin generation and fibrinogenolysis, superoxide scavenging and inhibition of leukocyte adhesion to nonendothelial matrix.	Arginine	0-3	prolactin	Homo sapiens	202-211
11013213-6	2000	The conserved and catalytically crucial arginine residue, identified by mutational analysis, is in a comparable position to the arginine finger in the Ras- and Cdc42-GAPs, suggesting that Gyp1p utilizes an arginine finger in the GAP reaction, in analogy to Ras- and Cdc42-GAPs.	Arginine	40-48	GTPase-activating protein GYP1	Saccharomyces cerevisiae S288C	188-193
11036505-6	2000	Significantly higher CuZn superoxide dismutase (CuZn-SOD) activity was observed in the L-arginine + L-NAME group compared to arginine.	Arginine	87-97	superoxide dismutase 1	Homo sapiens	21-46
11036505-6	2000	Significantly higher CuZn superoxide dismutase (CuZn-SOD) activity was observed in the L-arginine + L-NAME group compared to arginine.	Arginine	87-97	superoxide dismutase 1	Homo sapiens	48-56
11036505-6	2000	Significantly higher CuZn superoxide dismutase (CuZn-SOD) activity was observed in the L-arginine + L-NAME group compared to arginine.	Arginine	89-97	superoxide dismutase 1	Homo sapiens	21-46
11036505-6	2000	Significantly higher CuZn superoxide dismutase (CuZn-SOD) activity was observed in the L-arginine + L-NAME group compared to arginine.	Arginine	89-97	superoxide dismutase 1	Homo sapiens	48-56
11042688-2	2000	Although all cell lines contain the same p53 mutations at codons 175 (Arg--&gt;His) and 248 (Arg--&gt;Gln), the constitutive levels of p53 were progressively increased with the resistance of the cells to teniposide.	Arginine	93-96	tumor protein p53	Homo sapiens	135-138
11085283-2	2000	Argatroban is an arginine derivative, synthetic small molecule that binds to the active site of thrombin and inhibits its catalytic activity.	Arginine	17-25	coagulation factor II, thrombin	Homo sapiens	96-104
11004017-6	2000	We infer from the present data that 1) exercise is likely to induce release of both GHRH and somatostatin, 2) L-arginine may facilitate the effect of exercise by limiting somatostatin release, 3) GHRP-2 could further enhance the stimulatory impact of exercise by opposing central actions of somatostatin and/or heightening endogenous GHRH release, and 4) gender strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise.	Arginine	110-120	growth hormone releasing hormone	Homo sapiens	334-338
11029328-7	2000	L-Arginine administration increased exhaled NO production rate in all but NOS 2-deficient mice.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	74-79
11051120-1	2000	PURPOSE: Nitric oxide (NO), a short-lived radical synthesized from L-arginine by activation of the enzyme nitric oxide synthase (NOS), has been implicated in the pathophysiology of epilepsy by some investigators.	Arginine	67-77	nitric oxide synthase 2	Homo sapiens	106-127
11045785-13	2000	In conclusion, the codon 72 germ-line polymorphism (Arg/Pro) of the common tumor suppressor gene p53 contributes to heritable susceptibility for smoke-induced lung adenocarcinoma.	Arginine	52-55	tumor protein p53	Homo sapiens	97-100
11069088-5	2000	The putative centerin protein shares the highest sequence identity with thyroxine-binding globulin and possesses arginine/serine at its P1/P1" active site, suggesting that it interacts with a trypsin-like protease(s).	Arginine	113-121	kallikrein related peptidase 11	Homo sapiens	192-213
11011154-7	2000	Fibrinogen bound to purified alpha(5)beta(1) in a time-dependent, specific, and saturable manner in the presence of Mn(2+), and the binding was blocked completely by Arg-Gly-Asp (RGD)-containing peptides and by anti-alpha(5) and anti-alpha(5)beta(1) monoclonal antibodies.	Arginine	166-169	fibrinogen beta chain	Homo sapiens	0-10
11061526-3	2000	GHRH + arginine (GHRH+ARG) is the most reliable alternative to the insulin-induced hypoglycemia test (ITT) as a provocative test for the diagnosis of GHD in adulthood, provided that appropriate cut-off limits are assumed (normal limits, 16.5 microg/L as 3rd and 9.0 microg/L as 1st centile).	Arginine	7-15	growth hormone releasing hormone	Homo sapiens	17-21
11089639-12	2000	On the other hand, only the Arg residue is conserved in HIF- 1alpha.	Arginine	28-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-67
11061509-0	2000	Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans.	Arginine	0-8	insulin like growth factor 1	Homo sapiens	64-92
11061509-0	2000	Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	130-162
11011142-1	2000	Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation.	Arginine	71-79	ADP-ribosyltransferase 2b	Rattus norvegicus	6-11
11011142-1	2000	Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation.	Arginine	71-79	ADP-ribosyltransferase 2b	Rattus norvegicus	6-9
11011142-1	2000	Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation.	Arginine	71-79	ADP-ribosyltransferase 2b	Rattus norvegicus	48-51
11092595-1	2000	Nitric oxide (NO) is synthesized from L-arginine (ARG) catalyzed by the enzyme nitric oxide synthase (NOS) and is important in the regulation of vascular tone, neurotransmission and host defense.	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	79-100
11092595-1	2000	Nitric oxide (NO) is synthesized from L-arginine (ARG) catalyzed by the enzyme nitric oxide synthase (NOS) and is important in the regulation of vascular tone, neurotransmission and host defense.	Arginine	50-53	nitric oxide synthase 2	Homo sapiens	79-100
11061509-10	2000	In conclusion, ARG counteracts the inhibitory effect of rhIGF-I on somatotroph responsiveness to GHRH in humans.	Arginine	15-18	growth hormone releasing hormone	Homo sapiens	97-101
11061526-3	2000	GHRH + arginine (GHRH+ARG) is the most reliable alternative to the insulin-induced hypoglycemia test (ITT) as a provocative test for the diagnosis of GHD in adulthood, provided that appropriate cut-off limits are assumed (normal limits, 16.5 microg/L as 3rd and 9.0 microg/L as 1st centile).	Arginine	22-25	growth hormone releasing hormone	Homo sapiens	0-4
11061526-5	2000	The GH responses to GHRH+ARG in these groups were also compared with that recorded in a group of age-matched normal subjects (NS) [n = 48 (20 M, 28 F); age, 27.7+/-0.8 yr].	Arginine	25-28	growth hormone 1	Homo sapiens	4-6
11061526-7	2000	The mean GH peak after GHRH+ARG in oGHD (2.8+/-0.8 microg/L) was lower (P &lt; 0.001) than that in iGHD (18.6+/-4.7 microg/L), which, in turn, was clearly lower (P &lt; 0.001) than that in GHNSD (31.3+/-1.6 microg/L).	Arginine	28-31	growth hormone 1	Homo sapiens	9-11
11061526-11	2000	All oGHD and iGHD with GH peak after GHRH+ARG lower than 9 microg/L had also GH peak lower than 3 microg/L after ITT.	Arginine	42-45	growth hormone 1	Homo sapiens	5-7
11061526-11	2000	All oGHD and iGHD with GH peak after GHRH+ARG lower than 9 microg/L had also GH peak lower than 3 microg/L after ITT.	Arginine	42-45	growth hormone 1	Homo sapiens	14-16
11061526-12	2000	In the patients in whom GHD was confirmed by retesting, the mean GH peak after GHRH+ARG was higher than that after ITT (3.4+/-0.5 vs. 1.9+/-0.4).	Arginine	84-87	growth hormone 1	Homo sapiens	24-26
11061526-13	2000	In conclusion, given appropriate cut-off limits, GHRH+ARG is as reliable as ITT for retesting patients who had undergone GH treatment in childhood.	Arginine	54-57	growth hormone 1	Homo sapiens	49-51
11072671-2	2000	In invasive cervical cancer, the arginine form of the p53 gene is estimated to be more susceptible to degradation mediated by tumour-associated human papilloma viruses (HPV) than the proline form.	Arginine	33-41	tumor protein p53	Homo sapiens	54-57
11036847-4	2000	GH secretion in subjects with a maximal GH increase &lt; 10 ng/ml after hypoglycemia was assessed by additional arginine stimulation.	Arginine	112-120	growth hormone 1	Homo sapiens	0-2
10915779-2	2000	Within this region of alpha(1S), a cluster of basic residues, Arg(681)-Lys(685), was previously reported to be indispensable for the activation of RyR1 in microsomal preparations and lipid bilayers.	Arginine	62-65	ryanodine receptor 1	Homo sapiens	147-151
11003663-4	2000	We provide further evidence suggesting that the unique arginine at position 54 (Arg 54) of the Bicoid homeodomain enables the protein to recognize X1 by specifically interacting with this position 4 guanine.	Arginine	55-63	bicoid	Drosophila melanogaster	95-101
11003663-4	2000	We provide further evidence suggesting that the unique arginine at position 54 (Arg 54) of the Bicoid homeodomain enables the protein to recognize X1 by specifically interacting with this position 4 guanine.	Arginine	80-83	bicoid	Drosophila melanogaster	95-101
11003663-5	2000	We also describe experiments to analyze the contribution of artificially introduced Arg 54 to DNA recognition by other Bicoid-related homeodomains, including that from the human disease protein Pitx2.	Arginine	84-87	bicoid	Drosophila melanogaster	119-125
11003663-5	2000	We also describe experiments to analyze the contribution of artificially introduced Arg 54 to DNA recognition by other Bicoid-related homeodomains, including that from the human disease protein Pitx2.	Arginine	84-87	paired like homeodomain 2	Homo sapiens	194-199
10862775-6	2000	The results parallel the alanine scanning mutagenesis data, i.e. heparin binding to the alpha1(V) chain involved Arg(912), Arg(918), and Arg(921) and two additional neighboring basic residues, Lys(905) and Arg(909).	Arginine	113-116	collagen type V alpha 1 chain	Homo sapiens	88-97
11008209-4	2000	The codon 72 p53 Pro allele was more frequently found in ESCC patients [odds ratio (OR) 1.86, 95% confidence interval (CI) 1.04-3.35 for Arg/Pro genotype and OR 2.56, 95% CI 1.29-5.08 for Pro/Pro genotype].	Arginine	137-140	tumor protein p53	Homo sapiens	13-16
10862775-6	2000	The results parallel the alanine scanning mutagenesis data, i.e. heparin binding to the alpha1(V) chain involved Arg(912), Arg(918), and Arg(921) and two additional neighboring basic residues, Lys(905) and Arg(909).	Arginine	123-126	collagen type V alpha 1 chain	Homo sapiens	88-97
10862775-6	2000	The results parallel the alanine scanning mutagenesis data, i.e. heparin binding to the alpha1(V) chain involved Arg(912), Arg(918), and Arg(921) and two additional neighboring basic residues, Lys(905) and Arg(909).	Arginine	123-126	collagen type V alpha 1 chain	Homo sapiens	88-97
10862775-6	2000	The results parallel the alanine scanning mutagenesis data, i.e. heparin binding to the alpha1(V) chain involved Arg(912), Arg(918), and Arg(921) and two additional neighboring basic residues, Lys(905) and Arg(909).	Arginine	123-126	collagen type V alpha 1 chain	Homo sapiens	88-97
10875933-6	2000	The effect of CgA-(1-78) was blocked by anti-CgA antibodies against epitopes including residues Arg(53), His(54), and Leu(57).	Arginine	96-99	chromogranin A	Homo sapiens	14-17
10875933-6	2000	The effect of CgA-(1-78) was blocked by anti-CgA antibodies against epitopes including residues Arg(53), His(54), and Leu(57).	Arginine	96-99	chromogranin A	Homo sapiens	45-48
10973586-0	2000	Impaired cognitive performance in ornithine transcarbamylase-deficient mice on arginine-free diet.	Arginine	79-87	ornithine transcarbamylase	Mus musculus	34-60
10970791-4	2000	A striking characteristic of GLUT9 is the presence of two arginines in the putative helices 7 and 8 at positions where the organic anion transporters harbour basic residues.	Arginine	58-67	solute carrier family 2 member 9	Homo sapiens	29-34
10994962-3	2000	PCR products of the proline [5"-x(G17)-x(C38)x-3"] and arginine variants [(5"-x(Gl7)-x(G38)x-3"] of the p53 gene are distinguished by an SNP (cytosine or guanine) and were discriminated using both quadrupole and quadrupole ion trap MS analysis.	Arginine	55-63	tumor protein p53	Homo sapiens	104-107
10973830-8	2000	Binding occurred independently of homoribopolymer binding to the C-terminal arginine-glycine-rich region (RGG box), suggesting that FMRP may bind multiple RNAs simultaneously.	Arginine	76-84	fragile X messenger ribonucleoprotein 1	Homo sapiens	132-136
10971459-2	2000	Sequencing of the entire coding sequence of the calcium-sensing receptor (CaR) gene revealed a novel heterozygous mutation at codon 395, leading to the substitution of a cysteine by an arginine residue (Cys395Arg) in the extracellular ligand-binding domain.	Arginine	185-193	calcium sensing receptor	Homo sapiens	48-72
10978258-2	2000	Its activity is modulated by 2 common amino acid polymorphisms at positions 192 (Gln--&gt;Arg) and 55 (Met--&gt;Leu) in the paraoxonase gene (P:ON1).	Arginine	90-93	paraoxonase 1	Homo sapiens	124-135
10978258-2	2000	Its activity is modulated by 2 common amino acid polymorphisms at positions 192 (Gln--&gt;Arg) and 55 (Met--&gt;Leu) in the paraoxonase gene (P:ON1).	Arginine	90-93	paraoxonase 1	Homo sapiens	142-147
10960065-12	2000	However, instead of generating large quantities of NO, iNOS appears to be generating superoxide, perhaps because of a deficiency in its substrate, L-arginine.	Arginine	147-157	nitric oxide synthase 2	Rattus norvegicus	55-59
10971459-2	2000	Sequencing of the entire coding sequence of the calcium-sensing receptor (CaR) gene revealed a novel heterozygous mutation at codon 395, leading to the substitution of a cysteine by an arginine residue (Cys395Arg) in the extracellular ligand-binding domain.	Arginine	185-193	calcium sensing receptor	Homo sapiens	74-77
11240705-1	2000	Recent analysis of the codon-72 polymorphism of the p53 gene, the allele encoding proline or arginine, suggested that the homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV).	Arginine	93-101	tumor protein p53	Homo sapiens	52-55
10973927-3	2000	In contrast, cyclic stretch inhibited the catabolism of L-arginine to nitric oxide (NO) by blocking inducible NO synthase expression.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	100-121
11240705-1	2000	Recent analysis of the codon-72 polymorphism of the p53 gene, the allele encoding proline or arginine, suggested that the homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV).	Arginine	133-136	tumor protein p53	Homo sapiens	52-55
11240705-1	2000	Recent analysis of the codon-72 polymorphism of the p53 gene, the allele encoding proline or arginine, suggested that the homozygous Arg/Arg genotype is a significant risk factor for cervical cancer associated with human papillomavirus (HPV).	Arginine	137-140	tumor protein p53	Homo sapiens	52-55
10956019-1	2000	A novel thrombin-like enzyme (named contortrixobin) has been purified to homogeneity from the venom of Agkistrodon contortrix contortrix by affinity chromatography on arginine-Sepharose, anionic exchange chromatography, and HPLC.	Arginine	167-175	coagulation factor II, thrombin	Homo sapiens	8-16
11008076-1	2000	BACKGROUND: To determine whether genetic factors are involved in the development of renal dysfunction due to cyclosporine nephrotoxicity, we analyzed 2 polymorphisms in the signal sequence of the transforming growth factor (TGF)-beta 1 gene; codon 10 (Leu(10) --&gt; Pro) and codon 25 (Arg(25) --&gt; Pro).	Arginine	286-289	transforming growth factor beta 1	Homo sapiens	196-235
10972671-3	2000	We have shown activation of Jun N-terminal kinase/stress-activated protein kinase (SAPK) and p42/44 mitogen-activated protein kinase (MAPK) in stretched MCs and have also demonstrated that L-arginine decreases resident cell proliferation and protects against glomerulosclerosis in remnant kidney glomeruli, presumably by increasing nitric oxide (NO) production.	Arginine	189-199	mitogen-activated protein kinase 9	Homo sapiens	83-87
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Arginine	76-84	arginyltransferase 1	Mus musculus	88-92
11126384-4	2000	Aflatoxin B1 exposure leads to mutations in the p53 tumor suppressor gene, most commonly a transversion in codon 249 that leads to a substitution of serine for arginine in the p53 protein.	Arginine	160-168	tumor protein p53	Homo sapiens	48-51
11126384-4	2000	Aflatoxin B1 exposure leads to mutations in the p53 tumor suppressor gene, most commonly a transversion in codon 249 that leads to a substitution of serine for arginine in the p53 protein.	Arginine	160-168	tumor protein p53	Homo sapiens	176-179
10972680-8	2000	In addition, the CsA-induced up-regulated expression of TGF-beta1, PAI-1, and the matrix proteins biglycan, fibronectin, and collagen I was significantly increased with L-NAME and strikingly improved with L-Arg.	Arginine	205-210	transforming growth factor, beta 1	Rattus norvegicus	56-65
10972680-8	2000	In addition, the CsA-induced up-regulated expression of TGF-beta1, PAI-1, and the matrix proteins biglycan, fibronectin, and collagen I was significantly increased with L-NAME and strikingly improved with L-Arg.	Arginine	205-210	serpin family E member 1	Rattus norvegicus	67-72
10972680-8	2000	In addition, the CsA-induced up-regulated expression of TGF-beta1, PAI-1, and the matrix proteins biglycan, fibronectin, and collagen I was significantly increased with L-NAME and strikingly improved with L-Arg.	Arginine	205-210	biglycan	Rattus norvegicus	98-106
11002987-4	2000	A competitive inhibitor of the L-arginine-dependent effector pathway, NG-monomethyl-L-arginine, virtually abolished the inhibitory effects induced by IFN-gamma.	Arginine	31-41	interferon gamma	Mus musculus	150-159
11002987-5	2000	From this finding it appears that the inhibitory effects induced by IFN-gamma in macrophages may be mediated by an L-arginine-dependent effector pathway that involves NO production.	Arginine	115-125	interferon gamma	Mus musculus	68-77
10831589-2	2000	A factor VIII human antibody, A-FF, with C2 epitope, exclusively inhibited factor VIII activation and cleavage at Arg(1689) by thrombin.	Arginine	114-117	coagulation factor II, thrombin	Homo sapiens	127-135
10831589-9	2000	Furthermore, C2-specific affinity purified F(ab)"(2) of A-FF, and the recombinant C2 domain inhibited thrombin cleavage at Arg(1689).	Arginine	123-126	coagulation factor II, thrombin	Homo sapiens	102-110
10831589-10	2000	Our results indicate that the C2 domain contains the thrombin-binding site responsible for the cleavage at Arg(1689).	Arginine	107-110	coagulation factor II, thrombin	Homo sapiens	53-61
10944442-10	2000	Codon is changed from CGA (arginine) to TGA (stop).	Arginine	27-35	chromogranin A	Homo sapiens	22-25
10918193-12	2000	Homozygous codon-72 p53-Arg apparently confers a higher susceptibility to HPV-associated cervical tumorigenesis.	Arginine	24-27	tumor protein p53	Homo sapiens	20-23
10952997-6	2000	Remarkably, arginine methylation interferes with Sky1p-mediated phosphorylation, thereby indirectly influencing the Npl3p-Mtr10p interaction in vivo and negatively regulating nuclear import of Npl3p.	Arginine	12-20	serine/threonine protein kinase SKY1	Saccharomyces cerevisiae S288C	49-54
10933889-7	2000	Alternatively, strong synergism was observed in RARbeta between Ser(280) and Arg(269) for RA-binding and RA-dependent transactivation activity.	Arginine	77-80	retinoic acid receptor beta	Homo sapiens	48-55
10950934-1	2000	Endogenously produced asymmetrically methylated arginine residues are competitive inhibitors of all three isoforms of nitric oxide synthase (NOS).	Arginine	48-56	nitric oxide synthase 2	Homo sapiens	118-139
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Arginine	100-103	complement C1s	Homo sapiens	22-25
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Arginine	100-103	complement C1r	Homo sapiens	26-29
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Arginine	100-103	complement C1r	Homo sapiens	30-33
10925288-1	2000	The activation of the C1s-C1r-C1r-C1s tetramer in the C1 complex, which involves the cleavage of an Arg-Ile bond in the catalytic domains of the subcomponents, is a two-step process.	Arginine	100-103	complement C1s	Homo sapiens	34-37
11051565-1	2000	We have studied the reaction of reduced nitric-oxide synthase (NOS) with molecular oxygen at -30 degrees C. In the first reaction cycle (from L-Arg to hydroxy-L-Arg), an oxygen adduct complex formed rapidly.	Arginine	142-147	nitric oxide synthase 2	Homo sapiens	40-61
10950934-2	2000	The enzyme dimethylarginine dimethylaminohydrolase (DDAH) specifically hydrolyzes these asymmetrically methylated arginine residues to citrulline and methylamines.	Arginine	19-27	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	52-56
10940568-1	2000	S1 mapping showed that at least a significant portion of the 5S rRNA and tRNA(Arg)(ACG) is co-transcribed in canola chloroplast, making trnR the last gene transcribed in an operon of which the final sequence is 5"-16S-tRNA(Ile)-tRNA(Ala)-23S-4.5S-5S-tRNA(Arg)-3".	Arginine	78-81	trnR	Brassica napus	136-140
10930571-7	2000	Interestingly, Arg-610 is located within one of the two pleckstrin homology (PH) domains of the FGD1 gene and it corresponds to a highly conserved residue which has been involved in InsP binding in PH domains of other proteins.	Arginine	15-18	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	96-100
10940568-1	2000	S1 mapping showed that at least a significant portion of the 5S rRNA and tRNA(Arg)(ACG) is co-transcribed in canola chloroplast, making trnR the last gene transcribed in an operon of which the final sequence is 5"-16S-tRNA(Ile)-tRNA(Ala)-23S-4.5S-5S-tRNA(Arg)-3".	Arginine	255-258	trnR	Brassica napus	136-140
10922411-6	2000	Nine families carried an identical alteration consisting of the insertion of arginine at position 113 of p16(INK4a), and one carried a missense mutation, in which the valine at position 115 was replaced with a glycine.	Arginine	77-85	cyclin dependent kinase inhibitor 2A	Homo sapiens	105-108
10913364-3	2000	FMLP-stimulated neutrophils exposed to l-arginine showed increased and prolonged aggregation, whereas cells pretreated with L-NAME did not differ from FMLP-stimulated controls.	Arginine	39-49	formyl peptide receptor 1	Homo sapiens	0-4
10801840-5	2000	Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor.	Arginine	196-199	vasoactive intestinal peptide	Homo sapiens	54-57
10952667-2	2000	Since cNOS and arginase, which hydrolyzes L-arginine to L-ornithine and urea, use L-arginine as a common substrate, competition between both enzymes for the substrate could be involved in the regulation of cholinergic airway reactivity.	Arginine	42-52	nitric oxide synthase, endothelial	Cavia porcellus	6-10
10952667-2	2000	Since cNOS and arginase, which hydrolyzes L-arginine to L-ornithine and urea, use L-arginine as a common substrate, competition between both enzymes for the substrate could be involved in the regulation of cholinergic airway reactivity.	Arginine	82-92	nitric oxide synthase, endothelial	Cavia porcellus	6-10
10952667-9	2000	The results indicate that endogenous arginase activity potentiates methacholine-induced airway constriction by inhibition of NO production, presumably by competition with cNOS for the common substrate, L-arginine.	Arginine	202-212	nitric oxide synthase, endothelial	Cavia porcellus	171-175
11019368-5	2000	In a previous work, we studied the effect of L-arginine, the substrate of nitric oxide synthetase (NOS), on utrophin expression at the muscle membrane.	Arginine	45-55	utrophin	Mus musculus	108-116
11019368-8	2000	In addition, we show here the utrophin increase in muscle extracts of mdx mice treated with L-arginine, after electrophoretic separation and western-blotting using this novel antibody, and thus extending the electrophoretic results previously obtained on myotube cultures to muscles of treated mice.	Arginine	92-102	utrophin	Mus musculus	30-38
10908276-10	2000	In summary, these results suggest that the opposite actions of L-Arg and HCG on human corpus luteum viability may, in part, be mediated by changes in the level of the anti-apoptotic activities caused by oestradiol and Bcl-2 protein.	Arginine	63-68	BCL2 apoptosis regulator	Homo sapiens	218-223
10899869-7	2000	Arginase competes with NOS-II for their common substrate, L-arginine.	Arginine	58-68	nitric oxide synthase 2, inducible	Mus musculus	23-29
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	56-60	insulin	Homo sapiens	11-18
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	56-60	insulin	Homo sapiens	80-87
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	57-60	insulin	Homo sapiens	11-18
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	57-60	insulin	Homo sapiens	80-87
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	57-60	insulin	Homo sapiens	128-135
10937511-2	2000	OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion.	Arginine	57-60	insulin	Homo sapiens	128-135
10906155-3	2000	Components of the L-arginine metabolic pathway, especially inducible nitric oxide (NO) synthase (iNOS), ornithine aminotransferase (OAT), and ornithine decarboxylase (ODC), have been associated with glomerular scarring.	Arginine	18-28	nitric oxide synthase 2, inducible	Mus musculus	97-101
10947940-5	2000	In rat blood, peptides with carboxy-terminal lysine or arginine residues protected the phage against complement-mediated inactivation by binding C-reactive protein.	Arginine	55-63	C-reactive protein	Rattus norvegicus	145-163
10983978-4	2000	We demonstrate here that mutations in the serine- and arginine-rich domain and RNA recognition motif of PGC-1 interfere with the ability of PGC-1 to induce mRNAs of target genes.	Arginine	54-62	PPARG coactivator 1 alpha	Homo sapiens	140-145
10783390-5	2000	Radiochemical sequencing indicated that the N-terminal methionine of the lysate-produced RGS4 was replaced with arginine.	Arginine	112-120	regulator of G-protein signaling 4	Mus musculus	89-93
10918219-2	2000	L-arginine is known to be metabolized by one of two pathways: nitric oxide synthase (NOS), producing nitric oxide (NO), or arginase, producing ornithine.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	62-83
10923019-11	2000	The loss of a functional iNOS gene abrogates the beneficial effect of arginine in wound healing.	Arginine	70-78	nitric oxide synthase 2, inducible	Mus musculus	25-29
10770944-5	2000	Here, we identify specific arginine residues (Arg(394) and Arg(396)) in the beta-arrestin 2 C terminus that mediate beta-arrestin binding to AP-2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 independently of clathrin binding.	Arginine	27-35	arrestin beta 1	Homo sapiens	188-209
10783390-6	2000	Since N-terminal arginine is a destabilizing residue not encoded by RGS4 mRNA, we conclude that the degron of RGS4 is generated through the removal of N-terminal methionine and enzymatic arginylation of the resulting N-terminal cysteine.	Arginine	17-25	regulator of G-protein signaling 4	Mus musculus	110-114
11876871-14	2000	L-arginine-supplemented early enteral feeding could further increase the gene expression of albumin possibly by reducing the expression of TNFalpha, IL-1alpha and IL-6R and did not increase the expression of iNOS.	Arginine	0-10	tumor necrosis factor	Rattus norvegicus	139-147
11876871-14	2000	L-arginine-supplemented early enteral feeding could further increase the gene expression of albumin possibly by reducing the expression of TNFalpha, IL-1alpha and IL-6R and did not increase the expression of iNOS.	Arginine	0-10	interleukin 1 alpha	Rattus norvegicus	149-158
11876871-14	2000	L-arginine-supplemented early enteral feeding could further increase the gene expression of albumin possibly by reducing the expression of TNFalpha, IL-1alpha and IL-6R and did not increase the expression of iNOS.	Arginine	0-10	interleukin 6 receptor	Rattus norvegicus	163-168
10915051-0	2000	The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position.	Arginine	104-112	coagulation factor II, thrombin	Homo sapiens	28-36
10887116-4	2000	Epitope-mapping studies revealed that scFv VK34 is directed against amino acid residues Arg(484)-Ile(508), a previously identified binding site for factor VIII inhibitors in the A2 domain.	Arginine	88-91	immunglobulin heavy chain variable region	Homo sapiens	38-42
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	12-15	plasminogen activator, urokinase	Homo sapiens	137-140
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	12-15	plasminogen activator, tissue type	Homo sapiens	145-148
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	170-178	plasminogen activator, urokinase	Homo sapiens	137-140
10801785-3	2000	Thrombin activates the Factor XIII a(2) dimer by cleaving the Factor XIII activation peptide segment at the Arg(37)-Gly(38) peptide bond.	Arginine	108-111	coagulation factor II, thrombin	Homo sapiens	0-8
10880389-0	2000	Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation.	Arginine	109-112	fibrinogen beta chain	Homo sapiens	0-10
10894822-4	2000	We examined whether 2 common polymorphisms of the paraoxonase (PON1) gene leading to a methionine (M allele)-leucine (L allele) interchange at position 54 and an arginine (B allele)-glutamine (A allele) interchange at position 191 are associated with the presence and progression of WMLs.	Arginine	162-170	paraoxonase 1	Homo sapiens	63-67
10952457-7	2000	Insulin secretion in response to arginine was considerably although not significantly lower in IGT subjects.	Arginine	33-41	insulin	Homo sapiens	0-7
10960189-1	2000	Nitric oxide synthase (NOS) catalyses the conversion of L-arginine to nitric oxide (NO) which plays an important role in the regulation of cellular functions and intracellular communications.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	0-21
10866806-0	2000	Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin.	Arginine	23-31	actin	Saccharomyces cerevisiae S288C	75-80
10866806-1	2000	Actin ADP-ribosylated at arginine 177 is unable to hydrolyze ATP, and the R177 side chain is in a position similar to that of the catalytically essential lysine 71 in heat shock cognate protein Hsc70, another member of the actin-fold family of proteins.	Arginine	25-33	actin	Saccharomyces cerevisiae S288C	0-5
10912770-1	2000	Cardiovascular responses to L-arginine and nitric oxide (NO) are augmented in the rostral ventrolateral medulla (RVLM) of spontaneously hypertensive rats (SHR), and the intravenous injection of superoxide dismutase (SOD) mimetic decreases the arterial pressure in these rats.	Arginine	28-38	superoxide dismutase 1	Homo sapiens	216-219
10918489-3	2000	An HveA cDNA from CLL cells was found to encode Arg--&gt;Lys and Val--&gt;Iso substitutions at amino acids 17 and 241, respectively.	Arginine	48-51	TNF receptor superfamily member 14	Homo sapiens	3-7
10912770-3	2000	For this purpose, we administered L-arginine (SHR-Arg: 13.2 micromol/day, n=6), a stable membrane-permeable SOD mimetic, 4-hydroxy-2, 2,6,6-tetramethyl piperidine-1-oxyl (tempol) (SHR-Temp: 13.2 micromol/day, n=6), or vehicle (SHR-C: n=6) into the lateral ventricle of 12-week-old SHR for 2 weeks.	Arginine	34-44	superoxide dismutase 1	Homo sapiens	108-111
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Arginine	7-10	kininogen 1	Homo sapiens	63-73
10947204-4	2000	Only the first patient had alterations in the MMSDH coding region, revealing homozygosity for a 1336G > A transversion, which leads to substitution of arginine for highly conserved glycine at amino acid 446.	Arginine	151-159	aldehyde dehydrogenase 6 family member A1	Homo sapiens	46-51
10890554-4	2000	iNOS activity was additionally assessed using a [(14-)C]-labelled arginine to citrulline assay.	Arginine	66-74	nitric oxide synthase 2	Homo sapiens	0-4
10898620-6	2000	The more reactive glycoxidation products formed during the initial stages of incubation in the presence of oxygen accelerated the rate of glycation during the later stages of incubation and increased the involvement of arginine residues of LZM in the glycation reaction.	Arginine	219-227	lysozyme	Homo sapiens	240-243
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Arginine	22-31	apolipoprotein E	Homo sapiens	62-84
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Arginine	22-31	apolipoprotein E	Homo sapiens	125-129
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Arginine	7-10	kininogen 1	Homo sapiens	129-139
10958361-3	2000	DRB1*0432 is similar to *0413 but with a mutation at position 215, changing codon 72 (CGG--&gt;CAG; Arg--&gt;Gln).	Arginine	100-103	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
10860944-4	2000	Arg(11) and Arg(14) of the MCH ligand were identified as potential sites of interaction with Asp(123)(3.32).	Arginine	0-3	pro-melanin concentrating hormone	Homo sapiens	27-30
10860944-4	2000	Arg(11) and Arg(14) of the MCH ligand were identified as potential sites of interaction with Asp(123)(3.32).	Arginine	12-15	pro-melanin concentrating hormone	Homo sapiens	27-30
10860944-9	2000	We conclude that both Asp(123)(3.32) in the MCH receptor and Arg(11) in the MCH peptide are required for the formation of the MCH peptide/receptor complex and propose that they form a direct interaction that is critical for receptor function.	Arginine	61-64	pro-melanin concentrating hormone	Homo sapiens	76-79
10860944-9	2000	We conclude that both Asp(123)(3.32) in the MCH receptor and Arg(11) in the MCH peptide are required for the formation of the MCH peptide/receptor complex and propose that they form a direct interaction that is critical for receptor function.	Arginine	61-64	pro-melanin concentrating hormone	Homo sapiens	76-79
10837347-0	2000	Bioactive products of arginine in sepsis: tissue and plasma composition after LPS and iNOS blockade.	Arginine	22-30	nitric oxide synthase 2	Rattus norvegicus	86-90
10871849-0	2000	Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.	Arginine	4-12	cyclin dependent kinase inhibitor 2A	Homo sapiens	33-39
10866325-1	2000	L-Arginine is the common substrate for two enzymes, arginase and nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	65-86
10837347-10	2000	These data demonstrate changes in arginine metabolism before and after de novo iNOS activity.	Arginine	34-42	nitric oxide synthase 2	Rattus norvegicus	79-83
10837347-11	2000	Selective blockade of iNOS did not prevent uptake and can deregulate the production of other bioactive arginine metabolites.	Arginine	103-111	nitric oxide synthase 2	Rattus norvegicus	22-26
10835530-10	2000	This mutation substituted T for A in the codon 557, leading to the change of amino acid sequence (tryptophan for arginine) of the KIT protein.	Arginine	113-121	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	130-133
10839919-11	2000	The NO synthase inhibitors Nomega-nitro-l-arginine-methyl-esther and Nomega-nitro-l-arginine completely abolished the morphine-induced attenuation of NF-kappaB nuclear binding, demonstrating that the inhibitory action is mediated by NO release.	Arginine	42-50	nuclear factor kappa B subunit 1	Homo sapiens	150-159
10875439-3	2000	Human amyloid derived Abeta has an increased content of arginine (46%) and glutamate/glutamine residues (28%), but a decreased content of histidine residues (-32%) as compared to the expected amino acid content.	Arginine	56-64	amyloid beta precursor protein	Homo sapiens	22-27
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Arginine	4-12	tumor protein p53	Homo sapiens	35-38
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Arginine	222-230	tumor protein p53	Homo sapiens	35-38
10845886-8	2000	Increased thrombus formation was observed when the Arg-Gly-Gly-Ser-vWF, which does not interact with alphaIIb-beta3, was added to vWD blood and perfused at 2600 s(-1).	Arginine	51-54	von Willebrand factor	Homo sapiens	67-70
10911769-0	2000	Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136--&gt;Ser) This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and rare mutant variant of ApoE, ApoE3 (Arg 136--&gt;Ser).	Arginine	132-135	apolipoprotein E	Homo sapiens	91-107
10911769-0	2000	Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136--&gt;Ser) This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and rare mutant variant of ApoE, ApoE3 (Arg 136--&gt;Ser).	Arginine	132-135	apolipoprotein E	Homo sapiens	113-130
10911769-0	2000	Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136--&gt;Ser) This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and rare mutant variant of ApoE, ApoE3 (Arg 136--&gt;Ser).	Arginine	381-384	apolipoprotein E	Homo sapiens	91-107
10911769-0	2000	Dietary fat clearance in type V hyperlipoproteinaemia secondary to a rare variant of human apolipoprotein E: the apolipoprotein E3 (Arg 136--&gt;Ser) This present case report describes two siblings with severe type V hyperlipoproteinaemia, diagnosed very early in life and due to the combination of the common apolipoprotein (Apo) E2 allele and rare mutant variant of ApoE, ApoE3 (Arg 136--&gt;Ser).	Arginine	381-384	apolipoprotein E	Homo sapiens	113-130
10809695-0	2000	In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex.	Arginine	43-51	histone deacetylase RPD3	Saccharomyces cerevisiae S288C	177-181
10866048-0	2000	Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.	Arginine	79-87	hepatocyte nuclear factor 4 alpha	Homo sapiens	123-133
10866048-1	2000	Subjects with the Q268X mutation in the hepatocyte nuclear factor (HNF)-4alpha gene (RW pedigree/maturity-onset diabetes of the young [MODY]-1) have diminished insulin and glucagon secretory responses to arginine.	Arginine	204-212	hepatocyte nuclear factor 4 alpha	Homo sapiens	40-78
10866048-1	2000	Subjects with the Q268X mutation in the hepatocyte nuclear factor (HNF)-4alpha gene (RW pedigree/maturity-onset diabetes of the young [MODY]-1) have diminished insulin and glucagon secretory responses to arginine.	Arginine	204-212	hepatocyte nuclear factor 4 alpha	Homo sapiens	135-142
10816474-11	2000	ARG-3 adhesin was found in 60% of the O20:H- CF-negative ETEC strains from Argentina; however, it appeared restricted to this serotype.	Arginine	0-3	adhesin	Escherichia coli	6-13
10727756-5	2000	This study provides evidence that hCG activates expression of iNOS protein in murine microglial cells accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium, and further offers that TNF-alpha acts on the NO synthesis from IFN-gamma-primed murine microglial cells.	Arginine	158-168	nitric oxide synthase 2, inducible	Mus musculus	62-66
10727756-5	2000	This study provides evidence that hCG activates expression of iNOS protein in murine microglial cells accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium, and further offers that TNF-alpha acts on the NO synthesis from IFN-gamma-primed murine microglial cells.	Arginine	158-168	tumor necrosis factor	Mus musculus	216-225
10850643-2	2000	Two reports indicate that the human RBC possesses nitric oxide synthase (NOS) activity-by the accumulation of nitrite across a membraned chamber in one and by the hydrolysis of labeled L-arginine, presumably to labeled L-citrulline, in the other.	Arginine	185-195	nitric oxide synthase 2	Homo sapiens	50-71
10844598-10	2000	However, L-arginine treatment led to a parallel decrease in the expression of ED1-positive cells, TGF-beta1 mRNA and collagen type IV mRNA and protein in rats with GeO2-induced nephropathy.	Arginine	9-19	transforming growth factor, beta 1	Rattus norvegicus	98-107
10857856-5	2000	GLN, ARG, and OKG all restored TNF-alpha secretion by macrophages of glucocorticoid-treated rats.	Arginine	5-8	tumor necrosis factor	Rattus norvegicus	31-40
10888199-1	2000	Different types of dipeptide building units containing N- or C-terminal arginine were prepared for synthesis of the backbone cyclic analogues of the peptide hormone bradykinin (BK: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg).	Arginine	72-80	kininogen 1	Homo sapiens	165-175
10882037-14	2000	These effects may be regarded as cellular measures to ensure a high L-arginine supply for iNOS.	Arginine	68-78	nitric oxide synthase 2	Rattus norvegicus	90-94
11032762-3	2000	The purpose of this study was to examine whether p53 Arg at the polymorphic position 72 could represent a risk factor for women with breast lesions.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
11032762-7	2000	The allele frequency of p53 Arg/Arg was much higher than that of the normal samples (61% versus 20%).	Arginine	28-31	tumor protein p53	Homo sapiens	24-27
11032762-7	2000	The allele frequency of p53 Arg/Arg was much higher than that of the normal samples (61% versus 20%).	Arginine	32-35	tumor protein p53	Homo sapiens	24-27
11032762-8	2000	Based on the findings of this study, it is suggested that p53 Arg homozygosity could represent a risk factor for the tumorigenesis of the breast.	Arginine	62-65	tumor protein p53	Homo sapiens	58-61
10916182-0	2000	Homozygous and heterozygous gly-188-Arg mutation of the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa.	Arginine	36-39	rhodopsin	Homo sapiens	56-65
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	117-120	coagulation factor II, thrombin	Homo sapiens	31-39
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	117-120	thrombopoietin	Homo sapiens	78-81
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	117-120	thrombopoietin	Homo sapiens	85-88
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	163-166	coagulation factor II, thrombin	Homo sapiens	31-39
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	163-166	thrombopoietin	Homo sapiens	78-81
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Arginine	163-166	thrombopoietin	Homo sapiens	85-88
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Arginine	69-72	thrombopoietin	Homo sapiens	29-32
10831526-1	2000	BACKGROUND: Human serum paraoxonase (PON1) exists in two polymorphic forms: one that differs in the amino acid at position 192 (glutamine and arginine, Q and R, respectively) and the second one that differs in the amino acid at position 55 (methionine and leucine, M and L, respectively).	Arginine	142-150	paraoxonase 1	Homo sapiens	37-41
10799243-3	2000	Since nitric oxide (NO), the product of the action of iNOS on molecular oxygen and l-arginine, produces vasodilation and decreases platelet aggregation, we believe it is an integral part of the initial detrusor response to obstruction.	Arginine	83-93	nitric oxide synthase 2, inducible	Mus musculus	54-58
10864042-3	2000	To identify Gar1p functional partners, we screened for mutations that are synthetically lethal with a gar1 mutant allele encoding a Gar1p mutant protein lacking its two glycine/arginine-rich (GAR) domains.	Arginine	177-185	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	102-106
10828960-8	2000	Four cleavage sites in prothrombin were identified by N-terminal sequencing of the fragments: Arg(155)-Ser(156), Arg(271)-Thr(272), Arg(284)-Thr(285), and Arg(393)-Ser(394).	Arginine	94-97	coagulation factor II, thrombin	Homo sapiens	23-34
10828960-8	2000	Four cleavage sites in prothrombin were identified by N-terminal sequencing of the fragments: Arg(155)-Ser(156), Arg(271)-Thr(272), Arg(284)-Thr(285), and Arg(393)-Ser(394).	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	23-34
10828960-8	2000	Four cleavage sites in prothrombin were identified by N-terminal sequencing of the fragments: Arg(155)-Ser(156), Arg(271)-Thr(272), Arg(284)-Thr(285), and Arg(393)-Ser(394).	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	23-34
10828960-8	2000	Four cleavage sites in prothrombin were identified by N-terminal sequencing of the fragments: Arg(155)-Ser(156), Arg(271)-Thr(272), Arg(284)-Thr(285), and Arg(393)-Ser(394).	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	23-34
10748127-4	2000	The asymmetrical dimethylation of arginine residues within these RG repeats dramatically reduces the binding of the SH3 domains of p59(fyn) and phospholipase Cgamma-1, but has no effect on their binding to the WW domain of FBP30.	Arginine	34-42	formin binding protein 4	Homo sapiens	223-228
10896023-2	2000	Attachment of these cells to fibronectin was significantly inhibited by NO donors, spermine NONOate and S-nitroso-N-acetyl-penicillamine or L-arginine, but not 8-bromoguanosine-3",5"-cyclic-monophosphate.	Arginine	140-150	fibronectin 1	Homo sapiens	29-40
10844598-14	2000	L-Arginine treatment inhibits collagen type IV synthesis possibly by suppressing macrophage invasion and the resultant TGF-beta1 expression in this nephropathy.	Arginine	0-10	transforming growth factor, beta 1	Rattus norvegicus	119-128
10801753-4	2000	L-Arginine, the principal substrate for nitric oxide synthases, added to the media suppressed the induction of TF activity significantly (by 66% for lipopolysaccharide induction and by 59% for interleukin-1beta induction) at 24 hours.	Arginine	0-10	interleukin 1 beta	Homo sapiens	193-210
10799519-1	2000	We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D).	Arginine	94-102	interleukin 13	Homo sapiens	41-55
10799519-1	2000	We created a novel mutated form of human interleukin-13 (IL-13) in which a positively charged arginine (R) at position 112 was substituted to a negatively charged aspartic acid (D).	Arginine	94-102	interleukin 13	Homo sapiens	57-62
10799301-3	2000	Inhibition of LPS/IFN-gamma-induced NO synthesis with the L-arginine analogue N(G)-monomethyl-L-arginine (L-NMMA) was accompanied by a significant up-regulation of iNOS mRNA that was reversed in the presence of the NO donor sodium nitroprusside (SNP).	Arginine	58-68	nitric oxide synthase 2	Homo sapiens	164-168
10794696-5	2000	Thus, the present study proposes two novel approaches for the preparation of high-affinity, specific thrombin inhibitors: two novel S1 anchoring moieties in the already large family of arginine/amidine-based inhibitors and novel peptidomimetic scaffolds obtained by incorporating tosylureido amino acids in the hydrophobic binding site(s).	Arginine	185-193	coagulation factor II, thrombin	Homo sapiens	101-109
10820009-6	2000	Methylation of Arg 106 in bovine MBP (Arg 107 in human), a naturally occurring modification of MBP, has been shown to affect the deimination of arginyl residues in the present study.	Arginine	15-18	myelin basic protein	Bos taurus	33-36
10820009-6	2000	Methylation of Arg 106 in bovine MBP (Arg 107 in human), a naturally occurring modification of MBP, has been shown to affect the deimination of arginyl residues in the present study.	Arginine	38-41	myelin basic protein	Bos taurus	33-36
10805774-4	2000	Taking into account the trypsin-like arginine specificity of uPA, (4-aminomethyl)phenylguanidine was selected as a potential P1 residue and iterative derivatization of its amino group with various hydrophobic residues, and structure-activity relationship-based optimization of the spacer in terms of hydrogen bond acceptor/donor properties led to N-(1-adamantyl)-N"-(4-guanidinobenzyl)urea as a highly selective nonpeptidic uPA inhibitor.	Arginine	37-45	plasminogen activator, urokinase	Homo sapiens	61-64
10794696-6	2000	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds due to facilitated metal (sodium) salts formation (at the relatively acidic SO(2)NHCO protons) as well as increased stability at hydrolysis (in vivo).	Arginine	124-132	coagulation factor II, thrombin	Homo sapiens	54-62
10813720-3	2000	RESULTS: Among these polymorphisms, the individuals carrying arginine/proline genotypes of p53 showed a 9.5-fold increase of cervical carcinoma risk (95% confidence interval [CI], 4.9-18.6) compared with those individuals carrying arginine/arginine genotypes.	Arginine	61-69	tumor protein p53	Homo sapiens	91-94
10819990-9	2000	We hypothesized that the area of Src that binds the Y + 3 residue contains either a positively charged lysine or an arginine, capable of ionic interactions with glutamic acid or cation-pi interactions with phenylalanine.	Arginine	116-124	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	33-36
10769174-8	2000	First, anti-peptide antibodies raised to specific sequences on either side of the reported cleavage site (Arg(1137)/Leu(1138)) clearly recognized soluble porcine somatic ACE, indicating that cleavage was C-terminal to Arg(1137).	Arginine	106-109	angiotensin I converting enzyme	Homo sapiens	170-173
10769174-11	2000	These data indicated that soluble human and porcine somatic ACE, whether generated in vivo or in vitro, have C-termini consistent with cleavage at a single site, the Arg(1203)/Ser(1204) bond, identical with the Arg(627)/Ser(628) site in testis ACE.	Arginine	166-169	angiotensin I converting enzyme	Homo sapiens	60-63
10769174-11	2000	These data indicated that soluble human and porcine somatic ACE, whether generated in vivo or in vitro, have C-termini consistent with cleavage at a single site, the Arg(1203)/Ser(1204) bond, identical with the Arg(627)/Ser(628) site in testis ACE.	Arginine	211-214	angiotensin I converting enzyme	Homo sapiens	60-63
10928171-6	2000	There was a trend towards an association between disease recurrence and the presence of the p53 codon 72 arginine homozygous genotype (OR = 3.41, p = 0.23).	Arginine	105-113	tumor protein p53	Homo sapiens	92-95
10813720-3	2000	RESULTS: Among these polymorphisms, the individuals carrying arginine/proline genotypes of p53 showed a 9.5-fold increase of cervical carcinoma risk (95% confidence interval [CI], 4.9-18.6) compared with those individuals carrying arginine/arginine genotypes.	Arginine	231-239	tumor protein p53	Homo sapiens	91-94
10813720-3	2000	RESULTS: Among these polymorphisms, the individuals carrying arginine/proline genotypes of p53 showed a 9.5-fold increase of cervical carcinoma risk (95% confidence interval [CI], 4.9-18.6) compared with those individuals carrying arginine/arginine genotypes.	Arginine	231-239	tumor protein p53	Homo sapiens	91-94
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	34-42	tumor protein p53	Homo sapiens	63-66
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	34-42	tumor protein p53	Homo sapiens	250-253
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	tumor protein p53	Homo sapiens	63-66
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	tumor protein p53	Homo sapiens	63-66
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Arginine	65-73	tumor protein p53	Homo sapiens	94-97
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Arginine	65-73	glutathione S-transferase mu 1	Homo sapiens	290-295
10768942-10	2000	These results show that IFN-gamma-activated murine Mphis kill P. brasiliensis conidia through the L-arginine-nitric oxide pathway.	Arginine	98-108	interferon gamma	Mus musculus	24-33
10803574-10	2000	The NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester decreased NO release, and pretreatment of cells with L-arginine reversed the effect.	Arginine	43-53	nitric oxide synthase 2	Homo sapiens	4-15
10809901-8	2000	On a third occasion 6 subjects additionally received an arginine bolus at &gt; 25 mM blood glucose, a test hitherto claimed to provoke maximal insulin secretion.	Arginine	56-64	insulin	Homo sapiens	143-150
10809901-9	2000	RESULTS: Insulin levels increased from 46 +/- 11 pM to 566 +/- 202 pM at 120 min, to 5104 +/- 1179 pM at 180 min and to maximally 8361 +/- 1368 pM after arginine (all P &lt; 0.001).	Arginine	153-161	insulin	Homo sapiens	9-16
10809901-12	2000	The insulin concentration after the arginine bolus at &gt; 25 mM glucose (n = 6) was 2773 +/- 855 pM vs. 7562 +/- 1168 pM for Imax (P = 0.003).	Arginine	36-44	insulin	Homo sapiens	4-11
10809901-13	2000	CONCLUSION: This novel insulin secretion test elicits a distinct pattern of plasma insulin concentrations in response to the secretagogues glucose, GLP-1 and arginine and is highly reproducible and can be used for differential characterization of islet function.	Arginine	158-166	insulin	Homo sapiens	23-30
10809901-13	2000	CONCLUSION: This novel insulin secretion test elicits a distinct pattern of plasma insulin concentrations in response to the secretagogues glucose, GLP-1 and arginine and is highly reproducible and can be used for differential characterization of islet function.	Arginine	158-166	insulin	Homo sapiens	83-90
10772824-6	2000	We now examine the role of arginine methylation on the nucleocytoplasmic localization of hnRNP A2 in the HEK-293 and NIH-3T3 mammalian cell lines.	Arginine	27-35	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	89-97
10772824-11	2000	The data suggest that hnRNP A2 may contain a novel nuclear localization sequence, regulated by arginine methylation, that lies in the R191-G253 region and may function independently of the M9 transportin-1-binding region in hnRNP A2.	Arginine	95-103	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	22-30
10769006-2	2000	This report demonstrates that the ability of a commercial preparation of catalase to inhibit concomitantly macrophage antimycobacterial activity and production of reactive nitrogen intermediates can be attributed, at least in part, to the depletion of L-arginine by contaminating arginase.	Arginine	252-262	catalase	Mus musculus	73-81
10902577-3	2000	A Lineweaver-Burk plot of the enzymatic activity demonstrated that the stimulation of NOS by insulin was related to the decrease in the Km for L-arginine, the substrate for NOS, with a simultaneous increase of Vmax.	Arginine	143-153	insulin	Homo sapiens	93-100
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Arginine	65-75	insulin	Homo sapiens	90-97
10810293-9	2000	We propose that an important inhibitory effect of NO on the insulin secretory processes stimulated by glucose and l-arginine is exerted via inactivation of islet acid glucan-1,4-alpha-glucosidase, a putative key enzyme in nutrient-stimulated insulin release.	Arginine	114-124	insulin	Homo sapiens	60-67
10810293-9	2000	We propose that an important inhibitory effect of NO on the insulin secretory processes stimulated by glucose and l-arginine is exerted via inactivation of islet acid glucan-1,4-alpha-glucosidase, a putative key enzyme in nutrient-stimulated insulin release.	Arginine	114-124	insulin	Homo sapiens	242-249
11272890-6	2000	All of the seven cases of fibrous dysplasia showed missense point mutations in Gsalpha at the Arg201 codon that resulted in Arg-to-His substitution in three cases and Arg-to-Cys substitution in four cases.	Arginine	94-97	GNAS complex locus	Homo sapiens	79-86
11272890-6	2000	All of the seven cases of fibrous dysplasia showed missense point mutations in Gsalpha at the Arg201 codon that resulted in Arg-to-His substitution in three cases and Arg-to-Cys substitution in four cases.	Arginine	124-127	GNAS complex locus	Homo sapiens	79-86
10831161-0	2000	Differential effects of smoking on myocardial infarction risk according to the Gln/Arg 192 variants of the human paraoxonase gene.	Arginine	83-86	paraoxonase 1	Homo sapiens	113-124
10831161-3	2000	PON1 genetic polymorphism includes PON1 Q, an isoform with a low activity toward paraoxon hydrolysis that has a glutamine at position 192, and PON1 R, the high-activity isoform with an arginine at position 192.	Arginine	185-193	paraoxonase 1	Homo sapiens	0-4
10802655-3	2000	The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro.	Arginine	151-154	tumor protein p53	Homo sapiens	53-57
10802655-3	2000	The binding of such mutants is influenced by whether TP53 (encoding p53) codon 72, by virtue of a common polymorphism in the human population, encodes Arg or Pro.	Arginine	151-154	tumor protein p53	Homo sapiens	68-71
10802655-4	2000	The ability of mutant p53 to bind p73, neutralize p73-induced apoptosis and transform cells in cooperation with EJ-Ras was enhanced when codon 72 encoded Arg.	Arginine	154-157	tumor protein p53	Homo sapiens	22-25
10834423-2	2000	OBJECTIVE: Insulin glargine (21A-Gly-30Ba-L-Arg-30Bb-L-Arg-human insulin) is a biosynthetic insulin analog with a prolonged duration of action compared with NPH human insulin.	Arginine	44-47	insulin	Homo sapiens	11-18
10834423-2	2000	OBJECTIVE: Insulin glargine (21A-Gly-30Ba-L-Arg-30Bb-L-Arg-human insulin) is a biosynthetic insulin analog with a prolonged duration of action compared with NPH human insulin.	Arginine	44-47	insulin	Homo sapiens	65-72
10756332-2	2000	To demonstrate the feasibility of this approach as well as its pro-drug and triggered release features, positively charged peptides [(Arg)(7)Cys] were successfully linked to tissue-specific plasminogen activator (tPA) using the crosslinking agent N-succinimidyl-3-(2-pyridyldithio)- propionate.	Arginine	134-137	plasminogen activator, tissue type	Homo sapiens	174-211
10756332-2	2000	To demonstrate the feasibility of this approach as well as its pro-drug and triggered release features, positively charged peptides [(Arg)(7)Cys] were successfully linked to tissue-specific plasminogen activator (tPA) using the crosslinking agent N-succinimidyl-3-(2-pyridyldithio)- propionate.	Arginine	134-137	plasminogen activator, tissue type	Homo sapiens	213-216
10754463-0	2000	Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer.	Arginine	11-19	tumor protein p53	Homo sapiens	35-38
10876055-4	2000	Tyr(NMe)-Arg-OH-nociception was completely blocked by the kyotorphin antagonist leucyl-arginine and its enzymatically stable, N-methylated analog, as well as by CP-99994, a specific neurokinin 1 antagonist.	Arginine	9-12	tachykinin precursor 1	Homo sapiens	182-194
10754463-2	2000	The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function.	Arginine	124-132	tumor protein p53	Homo sapiens	59-62
10785511-3	2000	BSP contains an Arg-Gly-Asp (RGD) motif found in other adhesive molecules that interact with cellular integrins.	Arginine	16-19	integrin binding sialoprotein	Homo sapiens	0-3
10754463-2	2000	The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function.	Arginine	124-132	tumor protein p53	Homo sapiens	155-158
10754463-2	2000	The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function.	Arginine	124-132	tumor protein p53	Homo sapiens	155-158
10766778-7	2000	Replacement of Arg of DP4 with Cys, mimicking the in vivo Arg(2458)-to-Cys(2458) mutation, abolished the activating effects of DP4.	Arginine	15-18	transcription factor Dp family member 3	Homo sapiens	22-25
10777585-2	2000	Arg-330 of TAFIa had been proposed to be the thrombin cleavage site based on studies with trypsin, but mutation of this residue to Gln did not prevent thrombin-mediated cleavage nor did mutation to Gln of the nearby Arg-320 residue.	Arginine	0-3	coagulation factor II, thrombin	Homo sapiens	45-53
10777524-2	2000	Thrombin converts TAFI to a carboxypeptidase B-like enzyme (TAFIa) by cleaving at Arg(92) in a process accelerated by the cofactor, thrombomodulin.	Arginine	82-85	coagulation factor II, thrombin	Homo sapiens	0-8
10777524-5	2000	The identity of the thrombin cleavage site responsible for loss of TAFIa activity was suggested to be Arg(330), but site-directed mutagenesis of this residue did not prevent inactivation of TAFIa by thrombin.	Arginine	102-105	coagulation factor II, thrombin	Homo sapiens	20-28
10839134-1	2000	Asymmetric dimethyl-L-arginine (ADMA) is a naturally occurring analogue of L-arginine (L-Arg), the substrate of nitric oxide synthase (NOS).	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	112-133
10839134-1	2000	Asymmetric dimethyl-L-arginine (ADMA) is a naturally occurring analogue of L-arginine (L-Arg), the substrate of nitric oxide synthase (NOS).	Arginine	87-92	nitric oxide synthase 2	Homo sapiens	112-133
10766778-7	2000	Replacement of Arg of DP4 with Cys, mimicking the in vivo Arg(2458)-to-Cys(2458) mutation, abolished the activating effects of DP4.	Arginine	15-18	transcription factor Dp family member 3	Homo sapiens	127-130
10766778-7	2000	Replacement of Arg of DP4 with Cys, mimicking the in vivo Arg(2458)-to-Cys(2458) mutation, abolished the activating effects of DP4.	Arginine	58-61	transcription factor Dp family member 3	Homo sapiens	22-25
10766778-7	2000	Replacement of Arg of DP4 with Cys, mimicking the in vivo Arg(2458)-to-Cys(2458) mutation, abolished the activating effects of DP4.	Arginine	58-61	transcription factor Dp family member 3	Homo sapiens	127-130
10753911-3	2000	In the present work, it is demonstrated that with a single mutation in its catalytic domain (Arg(273) --&gt; Leu) the yeast endoplasmic reticulum alpha1,2-mannosidase acquires the ability to transform Man(9)GlcNAc to Man(5)GlcNAc.	Arginine	93-96	mannosidase alpha class 1A member 2	Homo sapiens	146-166
10772915-0	2000	Measurement of 5-hydroxy-2-aminovaleric acid as a specific marker of iron-mediated oxidation of proline and arginine side-chain residues of low-density lipoprotein apolipoprotein B-100.	Arginine	108-116	apolipoprotein B	Homo sapiens	164-184
10834301-4	2000	L-arginine but not D-arginine (10(-6) - 10(-3) M) induced concentration-dependent relaxations only in the artery preincubated with LPS, the relaxations of which were attenuated by L-N(G)-nitroarginine methyl ester (LNAME, 10(-4) M), a non-selective iNOS inhibitor, and 1400W (10(-5) and 10(-4) M), a selective iNOS inhibitor.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	249-253
10834301-4	2000	L-arginine but not D-arginine (10(-6) - 10(-3) M) induced concentration-dependent relaxations only in the artery preincubated with LPS, the relaxations of which were attenuated by L-N(G)-nitroarginine methyl ester (LNAME, 10(-4) M), a non-selective iNOS inhibitor, and 1400W (10(-5) and 10(-4) M), a selective iNOS inhibitor.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	310-314
10834301-5	2000	Co-treatment of cycloheximide (10(-5) M), a protein synthesis inhibitor, or actinomycin D (10(-7) M), an RNA synthesis inhibitor with LPS inhibited the development of relaxing ability in response to L-arginine, indicating iNOS induction by LPS.	Arginine	199-209	nitric oxide synthase 2	Rattus norvegicus	222-226
10834301-9	2000	These results demonstrated that PGD2 and its metabolites inhibit iNOS induction by LPS in isolated rat mesenteric arteries, resulting in reduced relaxing ability in response to L-arginine.	Arginine	177-187	nitric oxide synthase 2	Rattus norvegicus	65-69
10749663-3	2000	VLDL was isolated from both apoE-deficient mice and mice expressing the human APOE2 (Arg(158)--&gt;Cys) and APOE3-Leiden isoforms on an Apoe(-/-),Ldlr(-/-) double knock-out background.	Arginine	85-88	CD320 antigen	Mus musculus	0-4
10753952-9	2000	The Arg(103) --&gt; Leu mutant bound to Ca-SP-Toyopearl with normal affinity and inhibited alpha-thrombin in a manner similar to native rHCII.	Arginine	4-7	coagulation factor II, thrombin	Homo sapiens	97-105
10753911-5	2000	These results demonstrate that Arg(273) is in part responsible for the specificity of the endoplasmic reticulum alpha1,2-mannosidase and that small differences in non-conserved amino acids interacting with the oligosaccharide substrate in the active site of class I alpha1, 2-mannosidases are responsible for the different specificities of these enzymes.	Arginine	31-34	mannosidase alpha class 1A member 2	Homo sapiens	112-132
10744677-1	2000	Long-[Arg(3)]insulin-like growth factor-I (IGF-I) is a potent analog of insulin-like growth factor-I that has been modified by a Glu(3) --&gt; Arg mutation and a 13-amino acid extension appended to the N terminus.	Arginine	6-9	insulin like growth factor 1	Homo sapiens	43-48
10727611-4	2000	However, modification of the LH receptor by substitution of Lys583--&gt;Arg (LHR-K583R) results in a receptor that is non-functional and which has a significantly shorter rotational correlation time of 130+/-12 micros following binding of hCG.	Arginine	72-75	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	29-40
10744677-0	2000	Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I.	Arginine	50-53	insulin like growth factor 1	Homo sapiens	57-85
10744677-1	2000	Long-[Arg(3)]insulin-like growth factor-I (IGF-I) is a potent analog of insulin-like growth factor-I that has been modified by a Glu(3) --&gt; Arg mutation and a 13-amino acid extension appended to the N terminus.	Arginine	6-9	insulin like growth factor 1	Homo sapiens	13-41
10744677-6	2000	The backbone dynamics of Long-[Arg(3)]IGF-I were investigated using (15)N nuclear spin relaxation and the heteronuclear nuclear Overhauser enhancement (NOE).	Arginine	31-34	insulin like growth factor 1	Homo sapiens	38-43
10744677-7	2000	There is a considerable degree of flexibility in Long-[Arg(3)]IGF-I, even in the alpha-helices, as indicated by an average ((1)H)(15)N NOE of 0.55 for the regions.	Arginine	55-58	insulin like growth factor 1	Homo sapiens	62-67
10767668-6	2000	Amino acids, including L-carnitine, taurine, and L-arginine, might also play a role in the reversal of insulin resistance.	Arginine	49-59	insulin	Homo sapiens	103-110
10727427-6	2000	Furthermore, down-regulation of cytokine-induced RANTES mRNA in keratinocytes was dependent on endogenously produced NO, as inhibition of the co-induced iNOS by L-N(G)-monomethyl-L-arginine increased cytokine-triggered RANTES expression in the cells.	Arginine	178-189	nitric oxide synthase 2	Homo sapiens	153-157
10830578-1	2000	In 1998, Storey and co-workers suggested that individuals homozygous for arginine (Arg) at codon 72 of the p53 gene are about seven times more susceptible to human papillomavirus (HPV)-related carcinogenesis than heterozygotes.	Arginine	73-81	tumor protein p53	Homo sapiens	107-110
10729387-3	2000	Two frequent mutations at the paraoxonase gene locus (PON1) are the leucine (L allele)--&gt;methionine (M allele) and the glutamine (Q allele)--&gt;arginine (R allele) substitutions at residues 55 and 192, respectively.	Arginine	148-156	paraoxonase 1	Homo sapiens	30-41
10729387-3	2000	Two frequent mutations at the paraoxonase gene locus (PON1) are the leucine (L allele)--&gt;methionine (M allele) and the glutamine (Q allele)--&gt;arginine (R allele) substitutions at residues 55 and 192, respectively.	Arginine	148-156	paraoxonase 1	Homo sapiens	54-58
10794489-1	2000	A case-control study was performed to investigate the risk of cervical cancer associated with p53 polymorphism at codon 72, encoding either arginine or proline.	Arginine	140-148	tumor protein p53	Homo sapiens	94-97
10738214-2	2000	The most frequent mutation of the p53 gene in HCC is an AGG(Arg) to AGT(Ser) missense mutation at codon 249 of exon 7.	Arginine	60-63	tumor protein p53	Homo sapiens	34-37
10830578-1	2000	In 1998, Storey and co-workers suggested that individuals homozygous for arginine (Arg) at codon 72 of the p53 gene are about seven times more susceptible to human papillomavirus (HPV)-related carcinogenesis than heterozygotes.	Arginine	83-86	tumor protein p53	Homo sapiens	107-110
10830578-8	2000	p53 Arg homozygosity (Arg/Arg) alone was associated with four-, six- or eight-fold increased risks for LGCIN, HGCIN or invasive cancer, respectively.	Arginine	4-7	tumor protein p53	Homo sapiens	0-3
10830578-8	2000	p53 Arg homozygosity (Arg/Arg) alone was associated with four-, six- or eight-fold increased risks for LGCIN, HGCIN or invasive cancer, respectively.	Arginine	22-25	tumor protein p53	Homo sapiens	0-3
10830578-8	2000	p53 Arg homozygosity (Arg/Arg) alone was associated with four-, six- or eight-fold increased risks for LGCIN, HGCIN or invasive cancer, respectively.	Arginine	22-25	tumor protein p53	Homo sapiens	0-3
10830578-18	2000	Our present small study results, which suggest a biologically relevant association, provide strong evidence that homozygous arginine at codon 72 of p53 may confer a higher susceptibility to HPV-associated intra-epithelial and invasive cervical neoplasia.	Arginine	124-132	tumor protein p53	Homo sapiens	148-151
10719058-4	2000	It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form.	Arginine	25-33	tumor protein p53	Homo sapiens	42-45
10719058-4	2000	It was revealed that the arginine form of p53 is more susceptible to degradation by the HPV E6 protein than the proline form and that patients with the arginine form have a higher risk of developing cancer than those with the proline form.	Arginine	152-160	tumor protein p53	Homo sapiens	42-45
10719058-9	2000	There was a difference in the distribution of p53 genotypes between high risk HPV-skin lesions and the controls, and the allele frequency of p53 Arg/Arg was much higher than the controls (65.5% versus 20%).	Arginine	149-152	tumor protein p53	Homo sapiens	141-144
10719058-10	2000	Therefore, it is suggested that p53 Arg homozygosity could represent a potential risk factor for tumorigenesis of the skin.	Arginine	36-39	tumor protein p53	Homo sapiens	32-35
10719058-5	2000	The purpose of this study was to examine whether p53 Arg at the polymorphic position 72 could represent a risk factor for patients with high risk HPV-associated malignant skin lesions.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
10719058-9	2000	There was a difference in the distribution of p53 genotypes between high risk HPV-skin lesions and the controls, and the allele frequency of p53 Arg/Arg was much higher than the controls (65.5% versus 20%).	Arginine	145-148	tumor protein p53	Homo sapiens	141-144
10706884-4	2000	The ETV6/ARG transcripts consisted of exon 1 to 5 of ETV6 and the 3" portion of ARG starting from exon 1B or exon 2, resulting in an open reading frame for a fusion protein consisting of the entire PNT oligomerization domain of ETV6 and all of the functional domains of ARG including the TK domain.	Arginine	9-12	ETS variant transcription factor 6	Homo sapiens	53-57
10852380-8	2000	Thus, Arg at the C-terminus is much stronger anchor for HLA-A*3303 than Lys.	Arginine	6-9	major histocompatibility complex, class I, A	Homo sapiens	56-61
10763825-9	2000	The results indicate that the leukaemic Abl-fusion proteins have catalytic specificities different from the normal kinases c-Abl and Arg and that Tel-Abl is capable to activate at least some pathways which are also upregulated by Bcr-Abl.	Arginine	133-136	ETS variant transcription factor 6	Homo sapiens	146-153
10698705-2	2000	Here we have investigated possible allosteric and stabilizing effects of H(4)Bip on neuronal NOS (NOS-I) during the conversion of substrate, L-arginine, into L-citrulline and nitric oxide.	Arginine	141-151	growth differentiation factor 10	Homo sapiens	77-80
10698705-2	2000	Here we have investigated possible allosteric and stabilizing effects of H(4)Bip on neuronal NOS (NOS-I) during the conversion of substrate, L-arginine, into L-citrulline and nitric oxide.	Arginine	141-151	nitric oxide synthase 2	Homo sapiens	98-103
10698705-3	2000	Indeed, in kinetic studies dual allosteric interactions between L-arginine and H(4)Bip activated recombinant human NOS-I to increase L-arginine turnover.	Arginine	64-74	nitric oxide synthase 2	Homo sapiens	115-120
10698705-3	2000	Indeed, in kinetic studies dual allosteric interactions between L-arginine and H(4)Bip activated recombinant human NOS-I to increase L-arginine turnover.	Arginine	133-143	growth differentiation factor 10	Homo sapiens	83-86
10698705-3	2000	Indeed, in kinetic studies dual allosteric interactions between L-arginine and H(4)Bip activated recombinant human NOS-I to increase L-arginine turnover.	Arginine	133-143	nitric oxide synthase 2	Homo sapiens	115-120
10706884-4	2000	The ETV6/ARG transcripts consisted of exon 1 to 5 of ETV6 and the 3" portion of ARG starting from exon 1B or exon 2, resulting in an open reading frame for a fusion protein consisting of the entire PNT oligomerization domain of ETV6 and all of the functional domains of ARG including the TK domain.	Arginine	80-83	ETS variant transcription factor 6	Homo sapiens	4-8
10771518-8	2000	However, increasing concentrations of L-arginine (NOS substrate) alone increased NO production in these cells and significantly enhanced PRL-stimulated cell proliferation.	Arginine	38-48	prolactin	Rattus norvegicus	137-140
10771518-11	2000	L-arginine or the NO releaser DEA/NO alone significantly inhibited apoptosis in Nb2 cells deprived of PRL for 5 days.	Arginine	0-10	prolactin	Rattus norvegicus	102-105
10771518-12	2000	Expression of the anti-apoptotic gene bcl-2, which was stimulated within 1 h by PRL, was upregulated by L-arginine or DEA/NO alone at 2 h and 8 h, respectively.	Arginine	104-114	BCL2, apoptosis regulator	Rattus norvegicus	38-43
10771518-12	2000	Expression of the anti-apoptotic gene bcl-2, which was stimulated within 1 h by PRL, was upregulated by L-arginine or DEA/NO alone at 2 h and 8 h, respectively.	Arginine	104-114	prolactin	Rattus norvegicus	80-83
10830991-9	2000	CGA (Arg, wild type) to TGA (term.)	Arginine	5-8	chromogranin A	Homo sapiens	0-3
10852380-9	2000	The preference for Arg and Lys at the C-terminus by HLA-A*1101 and HLA-A*3303 respectively may be due to sequences of three residues (70, 97 and 114) forming the F-pocket of these HLA class I molecules.	Arginine	19-22	major histocompatibility complex, class I, A	Homo sapiens	52-57
10852380-9	2000	The preference for Arg and Lys at the C-terminus by HLA-A*1101 and HLA-A*3303 respectively may be due to sequences of three residues (70, 97 and 114) forming the F-pocket of these HLA class I molecules.	Arginine	19-22	major histocompatibility complex, class I, A	Homo sapiens	67-72
10877506-5	2000	These neutrophils are chemotactically attracted and activated there by synergistic action of chemokines, IL-8 and Gro-alpha released by stimulated keratinocytes, and particularly by C5a/C5a des arg produced via the alternative complement pathway activation.	Arginine	194-197	complement C5a receptor 1	Homo sapiens	186-189
10722666-8	2000	Site-directed mutation of positions Arg(65) of ecalectin-NT and Arg(239) of ecalectin-CT to an aspartic acid residue resulted in the loss of both lactose-binding and ECA activities.	Arginine	36-39	galectin 9	Homo sapiens	47-56
10722666-8	2000	Site-directed mutation of positions Arg(65) of ecalectin-NT and Arg(239) of ecalectin-CT to an aspartic acid residue resulted in the loss of both lactose-binding and ECA activities.	Arginine	64-67	galectin 9	Homo sapiens	76-85
10706884-0	2000	A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.	Arginine	29-32	ETS variant transcription factor 6	Homo sapiens	6-10
10706884-0	2000	A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.	Arginine	29-32	ETS variant transcription factor 6	Homo sapiens	11-14
10706884-3	2000	We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)(q22;q11.2) and a t(1;12)(q25;p13), which has the remarkable feature to differentiate to mature eosinophils in culture with all-trans retinoic acid and cytokines.	Arginine	41-44	ETS variant transcription factor 6	Homo sapiens	22-26
10706884-4	2000	The ETV6/ARG transcripts consisted of exon 1 to 5 of ETV6 and the 3" portion of ARG starting from exon 1B or exon 2, resulting in an open reading frame for a fusion protein consisting of the entire PNT oligomerization domain of ETV6 and all of the functional domains of ARG including the TK domain.	Arginine	9-12	ETS variant transcription factor 6	Homo sapiens	4-8
10706884-4	2000	The ETV6/ARG transcripts consisted of exon 1 to 5 of ETV6 and the 3" portion of ARG starting from exon 1B or exon 2, resulting in an open reading frame for a fusion protein consisting of the entire PNT oligomerization domain of ETV6 and all of the functional domains of ARG including the TK domain.	Arginine	9-12	ETS variant transcription factor 6	Homo sapiens	53-57
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	ataxin 1	Homo sapiens	66-70
10743946-1	2000	Recent evidence is consistent with neurotensin (NT)(8-13) adopting a Type I beta-turn conformation while binding the NT receptor, which would place the cationic side-chains of Arg(8) and Arg(9) in close proximity.	Arginine	176-179	neurotensin	Homo sapiens	35-46
10743946-1	2000	Recent evidence is consistent with neurotensin (NT)(8-13) adopting a Type I beta-turn conformation while binding the NT receptor, which would place the cationic side-chains of Arg(8) and Arg(9) in close proximity.	Arginine	187-190	neurotensin	Homo sapiens	35-46
10692466-6	2000	Site-directed mutagenesis of Val-434, Arg-513, and Val-523 in mouse COX-2 to their COX-1 equivalents resulted in abrogation of 11- and 15-HETE production after aspirin treatment, confirming the hypothesis that these residues are the major isoform selectivity determinants regulating HETE production.	Arginine	38-41	cytochrome c oxidase I, mitochondrial	Mus musculus	83-88
10739497-0	2000	The effects of L-arginine on the release of prolactin from decidual explants in vitro.	Arginine	15-25	prolactin	Homo sapiens	44-53
10739497-1	2000	OBJECTIVE: Our aim was to elucidate a role for the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway in the control of decidual prolactin release in vitro.	Arginine	51-62	prolactin	Homo sapiens	142-151
10739497-3	2000	RESULTS: L -arginine, at 100 micromol/L, produced an increase in medium prolactin concentration after a 2-hour exposure; however, its inactive isomer, D -arginine, at the same concentration, did not.	Arginine	9-20	prolactin	Homo sapiens	72-81
10739497-4	2000	The increase in prolactin release initiated by L -arginine was sustained after a 24-hour incubation.	Arginine	47-58	prolactin	Homo sapiens	16-25
10739497-8	2000	CONCLUSIONS: These results suggest that the L -arginine-nitric oxide-cyclic guanosine monophosphate pathway is involved in the regulation of prolactin secretion by decidual tissue.	Arginine	44-55	prolactin	Homo sapiens	141-150
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	ataxin 7	Homo sapiens	94-98
10718826-4	2000	GHRH + arginine test is more potent than the classical tests and evaluates the maximal secretory capacity of somatotroph cells.	Arginine	7-15	growth hormone releasing hormone	Homo sapiens	0-4
10688832-6	2000	AMG inhibition was reversed by the addition of L-arginine, the substrate for iNOS.	Arginine	47-57	nitric oxide synthase 2	Homo sapiens	77-81
10718826-10	2000	On the other hand, the mean peak GH response to GHRH + ARG in GHNSD (43.7 +/- 3.7 micrograms/l) was markedly higher (P &lt; 0.001) than that in GHD (8.2 +/- 0.9 micrograms/l) but significantly lower (P &lt; 0.01) than that in NC (60.	Arginine	55-58	growth hormone releasing hormone	Homo sapiens	48-52
10675493-7	2000	Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine).	Arginine	221-229	chromogranin A	Homo sapiens	201-204
10699178-7	2000	Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction.	Arginine	116-119	interleukin 13	Homo sapiens	67-72
10677395-2	2000	PON1 has two genetic polymorphisms, both due to amino acid substitutions: one involving glutamine (Q genotype) and arginine (R genotype) at position 192, and the other involving leucine (L genotype) and methionine (M genotype) at position 55.	Arginine	115-123	paraoxonase 1	Homo sapiens	0-4
10720581-7	2000	An analysis of the distribution of -344C and Arg(173) genotypes indicated that these 2 variants were in complete linkage disequilibrium: -344C was present in a subset of chromosomes carrying the Arg(173) (P&lt;0.001 in low-renin hypertension).	Arginine	195-198	renin	Homo sapiens	223-228
10720581-11	2000	The decreased frequencies of the Arg(173) and -344C variants in the CYP11B2 appear to be genetically linked to low-renin hypertension in the Japanese population studied.	Arginine	33-36	renin	Homo sapiens	115-120
10720081-17	2000	In summary, the present data suggest that in patients with incidental adrenal adenomas the GH response to GHRH is blunted due to increased somatostatinergic tone, as it can be restored to normal by pretreatment with the functional somatostatin antagonist arginine.	Arginine	255-263	growth hormone releasing hormone	Homo sapiens	106-110
10699284-1	2000	In recent years, major progress has been made in the design and synthesis of fibrinogen antagonists, which are peptidomimetic Arg-Gly-Asp (RGD) analogs.	Arginine	126-129	fibrinogen beta chain	Homo sapiens	77-87
10720952-11	2000	RESULTS: All disease measures except proteinuria and including matrix accumulation, TGF-beta, fibronectin and PAI-1 production and mRNA expression for TGF-beta, fibronectin and PAI-1 were significantly and similarly reduced by about 50% in groups treated with L-arginine or with low protein diet.	Arginine	260-270	transforming growth factor, beta 1	Rattus norvegicus	151-159
10767182-6	2000	It is a C --&gt; T transition at position 508 of the cDNA (c.508 C --&gt; T) that changes the CGA codon for Arg(169) to the TGA stop codon (R169X).	Arginine	108-111	chromogranin A	Homo sapiens	94-97
10710375-7	2000	Nitric oxide synthase inhibition with an arginine analog (N(omega)-nitro-L-arginine methyl ester) depressed acetylcholine-induced relaxation but the left vs. right difference persisted.	Arginine	41-49	nitric oxide synthase 2	Sus scrofa	0-21
10711861-4	2000	Compared with placebo, L-arginine increased growth hormone (1.5+/-1.8 mg/L vs. 0.6+/-0.6 mg/L, P = .04) but had no effect on insulin and catecholamines.	Arginine	23-33	growth hormone 1	Homo sapiens	44-58
10772188-5	2000	RESULTS: The mRNA expression of TNF-alpha was significantly decreased in the spleen and lung (p &lt; .01, p &lt; .05), IFN-gamma in the lung (p &lt; .05), IL-1beta in the spleen (p &lt; .05), and IL-6 in the thymus and liver (p &lt; .05, p &lt; .05) in the arginine group when compared with the control group.	Arginine	257-265	tumor necrosis factor	Rattus norvegicus	32-41
10772188-6	2000	The production of TNF-alpha by splenic lymphocytes was suppressed in the arginine group in both concanavalin A (Con A)-treated and -untreated cultures (p &lt; .01, p &lt; .05).	Arginine	73-81	tumor necrosis factor	Rattus norvegicus	18-27
17018919-10	2000	The mutation causes in an Arg to Gln amino acid substitution (R752Q mutation) in the ligand binding domain of the androgen receptor and a complete androgen insensitivity.	Arginine	26-29	androgen receptor	Homo sapiens	114-131
18944613-9	2000	The amino acid positions 73, 102, 109, and 149 of the CP gene, where lysine, serine, arginine, and aspartic acid reside, respectively, were uniquely conserved for genotype I Taiwan isolates.	Arginine	85-93	golgi phosphoprotein 3	Homo sapiens	54-56
10688986-5	2000	In addition, L-glutamine, which blocks the generation of L-arginine from intracellular stores, enhanced the increase in perfusion pressure stimulated by endothelin-1.	Arginine	57-67	endothelin 1	Rattus norvegicus	153-165
10684729-9	2000	In all the vessels tested, vasopressin (arginine, 10 nM) elicited a transient increase in cell Ca(2+) and a constriction, irrespective of the diameter of the vessel.	Arginine	40-48	arginine vasopressin	Rattus norvegicus	27-38
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Arginine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	67-80
10707023-1	2000	The "ELR" (Glu-Leu-Arg) tripeptide sequence near the N-terminus of interleukin-8 (IL-8) contributes a large part of the receptor binding free energy.	Arginine	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
11023067-7	2000	Mutations of p53 were present in 3 of 38 HPV-positive samples: one with an ATG--&gt;TTG transversion (Met--&gt;Leu) in codon 237 of exon 7; and the others with a TGC--&gt;TGG transversion (Cys--&gt;Trp) in codon 242 of exon 7, and a CGT--&gt;CCT transversion (Arg--&gt;Pro) in codon 273 of exon 8, respectively.	Arginine	260-263	tumor protein p53	Homo sapiens	13-16
10683321-5	2000	A two-amino-acid change, from 79-proline-glycine-80 to 79-histidine-arginine-80, confers on the human Cyclin T1 the ability to cooperate with eTat in transcriptional activation.	Arginine	68-76	cyclin T1	Homo sapiens	102-111
11798760-11	2000	L-arginine ameliorated pulmonary vascular structural remodeling of hypoxic rats in association with an increase in indirect plasma NO concentration (P &lt; 0.05) and an inhibited ET-1 mRNA expression.	Arginine	0-10	endothelin 1	Rattus norvegicus	179-183
11798760-12	2000	CONCLUSION: L-arginine plays an important role in the regulation of development of hypoxic pulmonary vascular remodeling and hypoxic pulmonary hypertension, promoting NO production and inhibiting ET-1 mRNA expression in hypoxic rats.	Arginine	12-22	endothelin 1	Rattus norvegicus	196-200
10686292-1	2000	The aim of the present study was to investigate the effect of arginine [Arg(8)]vasopressin (vasopressin) on proliferation of vascular smooth muscle cells and the mechanisms underlying the action of vasopressin.	Arginine	62-70	arginine vasopressin	Rattus norvegicus	79-90
10660623-0	2000	Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype.	Arginine	75-78	mitogen-activated protein kinase 3	Homo sapiens	24-28
10660623-0	2000	Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype.	Arginine	75-78	mitogen-activated protein kinase 3	Homo sapiens	29-35
10686292-1	2000	The aim of the present study was to investigate the effect of arginine [Arg(8)]vasopressin (vasopressin) on proliferation of vascular smooth muscle cells and the mechanisms underlying the action of vasopressin.	Arginine	62-70	arginine vasopressin	Rattus norvegicus	92-103
10686292-1	2000	The aim of the present study was to investigate the effect of arginine [Arg(8)]vasopressin (vasopressin) on proliferation of vascular smooth muscle cells and the mechanisms underlying the action of vasopressin.	Arginine	62-70	arginine vasopressin	Rattus norvegicus	92-103
10664464-3	2000	Arabidopsis Hcf136 is targeted exclusively by the Tat pathway in pea chloroplasts and no Sec-dependent transport is evident even when the twin-arginine is replaced by twin-lysine.	Arginine	143-151	photosystem II stability/assembly factor, chloroplast (HCF136)	Arabidopsis thaliana	12-18
10669563-0	2000	Structural basis of the thrombin selectivity of a ligand that contains the constrained arginine mimic (2S)-2-amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic acid at P1.	Arginine	87-95	coagulation factor II, thrombin	Homo sapiens	24-32
10652239-3	2000	In endotoxemia shock, inducible nitric oxide (NO) synthase (iNOS) is induced in hepatocytes and arginine is utilized for NO production.	Arginine	96-104	nitric oxide synthase 2	Rattus norvegicus	60-64
10706377-5	2000	The catalytically important residues (Arg-39, Ser-136, Tyr-149 and Lys-153) of MLCR were found in the peptide sequences of RHAR, despite the low residue identities between the two enzymes.	Arginine	38-41	carbonyl reductase 2	Mus musculus	79-83
10680816-2	2000	Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients.	Arginine	59-62	tumor protein p53	Homo sapiens	18-21
10652299-0	2000	Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2.	Arginine	28-36	fibroblast growth factor 2	Homo sapiens	74-100
10652299-3	2000	Using mass spectrometry and amino acid sequence analysis, we have shown that the 22- and 22.5-kDa forms of HMW FGF-2 contain five dimethylated arginines located at positions -22, -24, -26, -36, and -38 using the methionine residue normally used to initiate the 18-kDa form as position 0.	Arginine	143-152	fibroblast growth factor 2	Homo sapiens	111-116
10652299-4	2000	The 24-kDa form of HMW FGF-2 contains seven to eight dimethylated arginines located at positions -48, -50, and -52, in addition to positions -22, -24, -26, -36, and -38.	Arginine	66-75	fibroblast growth factor 2	Homo sapiens	23-28
10652299-6	2000	These findings indicate that HMW FGF-2, with the presence of five or more dimethylated Gly-Arg-Gly repeats, contains an RGG box-like domain, which may be important for protein-protein and/or protein-RNA interactions.	Arginine	91-94	fibroblast growth factor 2	Homo sapiens	33-38
10677296-3	2000	In one family with OSMED, a homozygous Gly-->Arg substitution has been described in COL11A2, which codes for the alpha2 chain of type XI collagen.	Arginine	45-48	glycoprotein hormone subunit alpha 2	Homo sapiens	113-119
10675738-2	2000	Over a 72-h period, indomethacin (10 mg kg(-1), s.c.) provoked a time-dependent increase in expression of iNOS (assessed by the conversion of radiolabelled L-arginine to citrulline) and enhancement of vascular leakage of radiolabelled human serum albumin in the jejunum which commenced 18 h after indomethacin.	Arginine	156-166	nitric oxide synthase 2	Rattus norvegicus	106-110
10732740-1	2000	An initial report suggested that patients homozygous for the arginine allele at codon 72 of P53 were at increased risk for human papillomavirus (HPV)-related cervical cancer, but other groups have not confirmed this finding.	Arginine	61-69	tumor protein p53	Homo sapiens	92-95
10648407-7	2000	Although dansyl-Glu-Gly-Arg-chloromethyl ketone inactivated-F. IXa inhibited the clotting activity of F.IXa, plasmin-treated F.IX did not.	Arginine	24-27	coagulation factor IX	Homo sapiens	102-107
10732742-3	2000	DNA sequencing confirmed the presence of a G to T base substitution within the Haelll site spanning codons 249 and 250 of the p53 gene that results in replacement of arginine (wild-type) by methionine at residue 249.	Arginine	166-174	tumor protein p53	Homo sapiens	126-129
10753041-5	2000	The arginine-induced insulin responses (AIR) were inversely associated with insulin sensitivity (r &gt; or = -0.55, p &lt; 0.001).	Arginine	4-12	insulin	Homo sapiens	21-28
10698487-3	2000	), 393: 229-234, 1998)] reported a 7-fold increased risk of cervical cancer associated with having an Arg/Arg polymorphism at codon 72 of p53 compared with the Pro/Arg heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4).	Arginine	102-105	tumor protein p53	Homo sapiens	138-141
10698487-3	2000	), 393: 229-234, 1998)] reported a 7-fold increased risk of cervical cancer associated with having an Arg/Arg polymorphism at codon 72 of p53 compared with the Pro/Arg heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4).	Arginine	106-109	tumor protein p53	Homo sapiens	138-141
10698487-3	2000	), 393: 229-234, 1998)] reported a 7-fold increased risk of cervical cancer associated with having an Arg/Arg polymorphism at codon 72 of p53 compared with the Pro/Arg heterozygotes (odds ratio, 7.4; 95% confidence interval, 2.1-29.4).	Arginine	106-109	tumor protein p53	Homo sapiens	138-141
10753041-5	2000	The arginine-induced insulin responses (AIR) were inversely associated with insulin sensitivity (r &gt; or = -0.55, p &lt; 0.001).	Arginine	4-12	insulin	Homo sapiens	76-83
10675363-4	2000	Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding.	Arginine	87-95	C-reactive protein	Homo sapiens	192-195
10688368-8	2000	They are chemotactically attracted and activated there by synergistic action of chemokines, IL-8 and Gro-a released by the stimulated keratinocytes, and particularly C5a/C5a des arg produced via the alternative complement pathway activation possibly on the surface of corneocytes.	Arginine	178-181	complement C5a receptor 1	Homo sapiens	166-169
10688368-8	2000	They are chemotactically attracted and activated there by synergistic action of chemokines, IL-8 and Gro-a released by the stimulated keratinocytes, and particularly C5a/C5a des arg produced via the alternative complement pathway activation possibly on the surface of corneocytes.	Arginine	178-181	complement C5a receptor 1	Homo sapiens	170-173
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	102-110	growth hormone releasing hormone	Homo sapiens	60-64
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	102-110	growth hormone releasing hormone	Homo sapiens	203-207
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	112-115	growth hormone releasing hormone	Homo sapiens	60-64
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	112-115	growth hormone releasing hormone	Homo sapiens	203-207
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	208-211	growth hormone releasing hormone	Homo sapiens	60-64
10664524-4	2000	On the other hand, it is well known that the GH response to GHRH in humans is markedly potentiated by arginine (ARG), which probably acts via inhibition of hypothalamic somatostatin release; in fact the GHRH+ARG test is known as one of the most reliable to evaluate the maximal secretory capacity of somatotroph cells.	Arginine	208-211	growth hormone releasing hormone	Homo sapiens	203-207
10735543-1	2000	BACKGROUND: Previous in vitro experiments have indicated that if the ninth codon of the hepatitis C virus (HCV) core gene is mutated from arginine to lysine, a short 16-kDa (P16) instead of a 21-kDa (P21) core protein will be produced.	Arginine	138-146	cyclin dependent kinase inhibitor 2A	Homo sapiens	174-177
10644829-6	2000	However, HPV-16 350T variants were significantly over-represented in p53 Arg homozygous women with cervical cancer.	Arginine	73-76	tumor protein p53	Homo sapiens	69-72
10644829-7	2000	This suggests that, in p53 Arg/Arg women, infection with HPV-16 350T variants confers a higher risk of cervical cancer.	Arginine	27-30	tumor protein p53	Homo sapiens	23-26
10644829-7	2000	This suggests that, in p53 Arg/Arg women, infection with HPV-16 350T variants confers a higher risk of cervical cancer.	Arginine	31-34	tumor protein p53	Homo sapiens	23-26
10698112-1	2000	Similar to nitric oxide synthase (NOS) cytochrome P450 isoforms (e.g. 3A and 4E) can produce nitric oxide from arginine.	Arginine	111-119	nitric oxide synthase 2	Homo sapiens	11-32
10698112-1	2000	Similar to nitric oxide synthase (NOS) cytochrome P450 isoforms (e.g. 3A and 4E) can produce nitric oxide from arginine.	Arginine	111-119	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-54
10698112-7	2000	The lowest energy conformation of the cytochrome P450 3A4-substrate complex was compared to the high resolution X-ray structure of the iNOS-arginine complex.	Arginine	140-148	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-53
10800760-11	2000	In obese PWS as well as in OB the GH response to GHRH+ARG was higher than that to GHRH+PD (p&lt;0.02) which, in turn, was higher than that to CLO (p&lt;0.001); all GH responses in obese PWS and OB were lower than those in NC (p&lt;0.001) but similar to those in normal weight PWS.	Arginine	54-57	growth hormone releasing hormone	Homo sapiens	49-53
10800762-3	2000	ARG is also able to potentiate the GH response to GHRH, likely inhibiting hypothalamic somatostatin; this combined test is one of the most potent to explore the maximal secretory capacity of somatotroph cells.	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	50-54
10800762-10	2000	The GH peak following ARG+GHRH (mean peak: 47.8+/-3.3 microg/l, p&lt;0.001; Cmax 22.4-150.0 microg/l) was clearly higher (p&lt;0.001) than that recorded after ARG alone.	Arginine	159-162	growth hormone releasing hormone	Homo sapiens	26-30
10800762-14	2000	ARG+GHRH is a more potent stimulus giving no false positive responses even after previous challenge with ARG alone.	Arginine	105-108	growth hormone releasing hormone	Homo sapiens	4-8
10775508-4	2000	The purpose of this study was to examine whether p53 Arg at the polymorphic position 72 could represent a risk factor for women with high-risk HPV-associated premalignant and malignant cervical lesions.	Arginine	53-56	tumor protein p53	Homo sapiens	49-52
10719811-1	2000	A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro).	Arginine	106-114	tumor protein p53	Homo sapiens	39-42
10674579-7	2000	The samples collected after arginine infusion, compared with those collected at baseline, showed significantly greater insulin and insulin/glucagon molar ratio values in diabetic (28 +/- 5 versus 11 +/- 1 microU/mL, P = .001; 29.4 +/- 1.7 versus 12.0 +/- 2.8, P = .001) and in Rh pregnant women (18 +/- 6 versus 7.7 +/- 0.7 microU/mL, P = .001; 30 +/- 9 versus 3.4 +/- 0.4 I/G, P = .001), whereas no significant difference was observed in the controls.	Arginine	28-36	insulin	Homo sapiens	119-126
10674579-7	2000	The samples collected after arginine infusion, compared with those collected at baseline, showed significantly greater insulin and insulin/glucagon molar ratio values in diabetic (28 +/- 5 versus 11 +/- 1 microU/mL, P = .001; 29.4 +/- 1.7 versus 12.0 +/- 2.8, P = .001) and in Rh pregnant women (18 +/- 6 versus 7.7 +/- 0.7 microU/mL, P = .001; 30 +/- 9 versus 3.4 +/- 0.4 I/G, P = .001), whereas no significant difference was observed in the controls.	Arginine	28-36	insulin	Homo sapiens	131-138
10775508-10	2000	Based on the findings of this study, it is suggested that p53 Arg homozygosity could possibly represent a potential risk factor for the tumorigenesis of the cervix.	Arginine	62-65	tumor protein p53	Homo sapiens	58-61
10775508-9	2000	The allele frequency of p53 Arg/Arg was much higher than the normal samples (46.5% versus 20.5% in HPV-negative normal smears and 20% in blood samples).	Arginine	28-31	tumor protein p53	Homo sapiens	24-27
10775508-9	2000	The allele frequency of p53 Arg/Arg was much higher than the normal samples (46.5% versus 20.5% in HPV-negative normal smears and 20% in blood samples).	Arginine	32-35	tumor protein p53	Homo sapiens	24-27
10739395-3	2000	Since synthetic polycationic peptides of the general formula (Arg)n, (Lys)n or (Arg-Lys)n inhibit GPIb-vWF interaction, they were suggested as potential antithrombotics.	Arginine	62-65	von Willebrand factor	Homo sapiens	103-106
10709858-1	2000	L-arginine is the substrate for nitric oxide (NO) production by each of the 3 NO synthase (NOS) isoforms encoded by the mammalian genome.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	78-89
10709858-5	2000	The arginine-citrulline cycle is induced in vascular cells by the same cytokines that trigger iNOS expression and provides the preferred source of substrate for NO production.	Arginine	4-12	nitric oxide synthase 2	Homo sapiens	94-98
10644716-0	2000	Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor.	Arginine	10-18	apolipoprotein E	Homo sapiens	41-57
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Arginine	115-123	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	56-62
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Arginine	115-123	mitogen-activated protein kinase 1	Homo sapiens	67-71
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Arginine	169-177	apolipoprotein E	Homo sapiens	14-30
10644696-8	2000	This marked difference in substrate specificity between DYRK1A and ERK2 can be explained by the requirement for an arginine at the P -3 site of DYRK substrates and its presumed interaction with aspartate 247 conserved in all DYRKs.	Arginine	115-123	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	56-60
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Arginine	169-177	apolipoprotein E	Homo sapiens	32-36
10644716-8	2000	Thus, the association of apoE with phospholipids allows Arg(172) to interact directly with the LDL receptor or with other residues in apoE to promote its receptor-active conformation.	Arginine	56-59	apolipoprotein E	Homo sapiens	25-29
10620706-0	2000	Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1.	Arginine	29-32	tyrosine hydroxylase	Homo sapiens	116-136
10625623-5	2000	The unique, highly conserved arginine residue in the C-terminal domain of L7/12 is not essential for the activation, excluding an "arginine finger"-type mechanism.	Arginine	29-37	ribosomal protein L7	Homo sapiens	74-79
10639097-8	2000	Each of the mutants desensitized more slowly than the WT 5-HT3A receptor, with the arginine and glycine mutations exhibiting the greatest effect (5-fold reduction).	Arginine	83-91	5-hydroxytryptamine receptor 3A	Homo sapiens	57-63
10623524-8	2000	A tight cluster of three lysine residues and one arginine residue atop beta-strands A and B, and identical among TIMP sequences, form the heart of a highly conserved electropositive patch that may interact with anionic components of the extracellular matrix.	Arginine	49-57	TIMP metallopeptidase inhibitor 1	Homo sapiens	113-117
10620706-0	2000	Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1.	Arginine	37-40	tyrosine hydroxylase	Homo sapiens	116-136
10691775-4	2000	There is evidence for inter-regulation of arginine pathways in the sense that agmatine is capable of inhibiting inducible nitric oxide synthase (iNOS), the inflammatory NOS isoform.	Arginine	42-50	nitric oxide synthase 2	Homo sapiens	112-143
11996107-1	2000	A polymorphism at codon 72 of gene p53 results in the presence of either arginine or proline at this position.	Arginine	73-81	tumor protein p53	Homo sapiens	35-38
10691775-4	2000	There is evidence for inter-regulation of arginine pathways in the sense that agmatine is capable of inhibiting inducible nitric oxide synthase (iNOS), the inflammatory NOS isoform.	Arginine	42-50	nitric oxide synthase 2	Homo sapiens	145-149
10615072-5	2000	Spermine-NO (1 microM) and L-arginine (400 microM) prevented the aminoguanidine-induced ablation of AP-1 activation in response to TNF.	Arginine	27-37	tumor necrosis factor	Homo sapiens	131-134
10678275-7	2000	L-arginine administration reduced the CVR response to ET-1 in SHR, whereas it did not change responses to ET-1 in WKY.	Arginine	0-10	endothelin 1	Rattus norvegicus	54-58
10678275-8	2000	These findings suggest that the augmented vasoconstriction of the coronary artery induced by ET-1 in hypertensive hearts was due to a reduction in nitric oxide release in coronary vessels and that L-arginine can partially inhibit the vasoconstrictive response of the coronary artery.	Arginine	197-207	endothelin 1	Rattus norvegicus	93-97
10644563-6	2000	With the use of the VIP(2)-R-selective ligand Ro-25-1553 in both species, inhibition of binding of (125)I-labeled VIP to acini showed a biphasic pattern with a high-affinity component (10%) and a second representing 90%.	Arginine	27-28	vasoactive intestinal peptide	Rattus norvegicus	20-23
10644563-6	2000	With the use of the VIP(2)-R-selective ligand Ro-25-1553 in both species, inhibition of binding of (125)I-labeled VIP to acini showed a biphasic pattern with a high-affinity component (10%) and a second representing 90%.	Arginine	27-28	vasoactive intestinal peptide	Rattus norvegicus	114-117
10644563-7	2000	The VIP(1)-R-selective ligand, [Lys(15),Arg(16),Leu(27)]VIP-(1-7)-GRF-(8-27), gave a monophasic pattern.	Arginine	40-43	vasoactive intestinal peptide	Rattus norvegicus	4-7
10644563-7	2000	The VIP(1)-R-selective ligand, [Lys(15),Arg(16),Leu(27)]VIP-(1-7)-GRF-(8-27), gave a monophasic pattern.	Arginine	40-43	vasoactive intestinal peptide	Rattus norvegicus	56-59
10644563-10	2000	At low concentrations (10 nM) of Ro-25-1553 and [Lys(15),Arg(16), Leu(27)]VIP-(1-7)-GRF(8-27), which only occupy VIP receptors, a 4-fold and a 56-fold increase in cAMP occurred, respectively.	Arginine	57-60	vasoactive intestinal peptide	Rattus norvegicus	74-77
11128552-6	2000	Our data indicate that induction of NO biosynthesis by IL-1beta depends on external arginine when cells are arginine-depleted for 24 hours.	Arginine	84-92	interleukin 1 beta	Homo sapiens	55-63
10901620-1	2000	Nitric oxide synthase (NOS) activities are responsible for the enzymatic conversion of L-arginine into NO and L-citrulline.	Arginine	87-97	nitric oxide synthase 2	Homo sapiens	0-21
11128552-6	2000	Our data indicate that induction of NO biosynthesis by IL-1beta depends on external arginine when cells are arginine-depleted for 24 hours.	Arginine	108-116	interleukin 1 beta	Homo sapiens	55-63
10607487-6	2000	C57BL/6-Fas(lpr) TdT-deficient mice had shorter VH CDR3 regions and fewer VH CDR3 arginines [0.6% versus 4.	Arginine	82-91	Fas (TNF receptor superfamily member 6)	Mus musculus	12-15
10633218-0	2000	Circulating insulin inhibits glucagon secretion induced by arginine in type 1 diabetes.	Arginine	59-67	insulin	Homo sapiens	12-19
10633218-1	2000	OBJECTIVE: To evaluate if insulin has a suppressive effect on the glucagon secretion stimulated by arginine in type 1 diabetes.	Arginine	99-107	insulin	Homo sapiens	26-33
10633218-10	2000	CONCLUSION: This study demonstrates that a high level of circulating insulin exerts an inhibitory effect on the glucagon response to arginine in type 1 diabetes.	Arginine	133-141	insulin	Homo sapiens	69-76
10634623-2	2000	In the L-arginine-NO pathway, NO synthase (NOS) converts L-arginine (L-Arg), the only known biologic substrate for NO formation, to NO and L-citrulline (L-Cit).	Arginine	69-74	nitric oxide synthase 2	Homo sapiens	30-41
10895031-3	2000	The homozygous p53 arginine allele (Arg/Arg) was detected in 22 (31%), the homozygous p53 proline allele (Pro/Pro) in 14 (19%) and the heterozygous allele (Arg/Pro) in 36 (50%) cases, respectively.	Arginine	19-27	tumor protein p53	Homo sapiens	15-18
10642318-14	2000	We next evaluated the role of iNOS and nNOS in the response to L-Arg.	Arginine	63-68	nitric oxide synthase 2, inducible	Mus musculus	30-34
12678529-14	2000	In addition, L-arginine caused significant decreases in the intraerythrocytic and the liver SOD, CAT and GSH-Px levels from the shock levels.	Arginine	13-23	catalase	Canis lupus familiaris	97-100
10766956-2	2000	Our AII-SDS titration absorption studies indicate the formation of a 1:2 AII:SDS complex in which two negatively charged SDS molecules attach to the AII positively charged N terminus and to Arg(2).	Arginine	190-193	angiotensinogen	Homo sapiens	4-7
10766956-2	2000	Our AII-SDS titration absorption studies indicate the formation of a 1:2 AII:SDS complex in which two negatively charged SDS molecules attach to the AII positively charged N terminus and to Arg(2).	Arginine	190-193	angiotensinogen	Homo sapiens	73-76
10766956-2	2000	Our AII-SDS titration absorption studies indicate the formation of a 1:2 AII:SDS complex in which two negatively charged SDS molecules attach to the AII positively charged N terminus and to Arg(2).	Arginine	190-193	angiotensinogen	Homo sapiens	73-76
10642318-15	2000	Addition of 0.5 mmol/L L-Arg to the bath decreased J(Cl) in THALs from iNOS and nNOS knockout mice by 37.7+/-6.4% (P&lt;0.05) and 31.8+/-8.3% (P&lt;0.01), respectively.	Arginine	23-28	nitric oxide synthase 2, inducible	Mus musculus	71-75
10634623-2	2000	In the L-arginine-NO pathway, NO synthase (NOS) converts L-arginine (L-Arg), the only known biologic substrate for NO formation, to NO and L-citrulline (L-Cit).	Arginine	7-17	nitric oxide synthase 2	Homo sapiens	30-41
10634623-2	2000	In the L-arginine-NO pathway, NO synthase (NOS) converts L-arginine (L-Arg), the only known biologic substrate for NO formation, to NO and L-citrulline (L-Cit).	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	30-41
10634367-2	2000	The acute insulin response to arginine was impaired in LADA vs. type 2 diabetes at all glucose levels, with the greatest impairment in the maximally stimulated insulin concentrations (P&lt;0.04).	Arginine	30-38	insulin	Homo sapiens	10-17
11480456-3	2000	The PON1 genetic polymorphisms of 192 Gln/Arg and 55 Leu/Met in the amino acid sequence are partly involved in the PON1 enzyme activity.	Arginine	42-45	paraoxonase 1	Homo sapiens	4-8
11480456-3	2000	The PON1 genetic polymorphisms of 192 Gln/Arg and 55 Leu/Met in the amino acid sequence are partly involved in the PON1 enzyme activity.	Arginine	42-45	paraoxonase 1	Homo sapiens	115-119
10976779-2	2000	Nitric oxide is a labile substance produced from the catabolism of L-arginine and not only causes vessel relaxation, but also inhibits platelet aggregation, smooth muscle cell proliferation, monocyte adhesion, adhesion molecules expression and endothelin-1 (ET-1) production.	Arginine	67-77	endothelin 1	Homo sapiens	258-262
10634367-2	2000	The acute insulin response to arginine was impaired in LADA vs. type 2 diabetes at all glucose levels, with the greatest impairment in the maximally stimulated insulin concentrations (P&lt;0.04).	Arginine	30-38	insulin	Homo sapiens	160-167
10678543-0	2000	Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans.	Arginine	103-113	angiotensin I converting enzyme	Homo sapiens	10-13
10995066-6	2000	Thus, the present study proposes two novel approaches for the preparation of high affinity, specific thrombin inhibitors: a novel S1 anchoring moiety in the already large family of arginine/amidine-based inhibitors, i.e., the SO2NHNHC(=NH)NH2 group, and novel non-peptidomimetic scaffolds obtained by incorporating alkyl-/aryl-substituted-pyridinium moieties in the hydrophobic binding site(s).	Arginine	181-189	coagulation factor II, thrombin	Homo sapiens	101-109
10995066-7	2000	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds.	Arginine	124-132	coagulation factor II, thrombin	Homo sapiens	54-62
10721668-0	2000	A nonsense mutation at Arg-1947 in the NF1 gene in a case of neurofibromatosis type 1 in a Korean patient.	Arginine	23-26	neurofibromin 1	Homo sapiens	39-42
10721668-0	2000	A nonsense mutation at Arg-1947 in the NF1 gene in a case of neurofibromatosis type 1 in a Korean patient.	Arginine	23-26	neurofibromin 1	Homo sapiens	61-85
10721668-1	2000	We report a case of neurofibromatosis (NF) 1 presenting as a C-to-T transition changing an Arg-1947 codon to a stop codon.	Arginine	91-94	neurofibromin 1	Homo sapiens	20-44
10721668-2	2000	Because this mutation has been described in multiple Caucasian and Japanese families, the codon CGA for Arg-1947 in the NF1 gene is considered to be a hotspot for mutation in neurofibromatosis type 1 in all ethnic groups.	Arginine	104-107	neurofibromin 1	Homo sapiens	120-123
10721668-2	2000	Because this mutation has been described in multiple Caucasian and Japanese families, the codon CGA for Arg-1947 in the NF1 gene is considered to be a hotspot for mutation in neurofibromatosis type 1 in all ethnic groups.	Arginine	104-107	neurofibromin 1	Homo sapiens	175-199
10678543-12	2000	Enhanced renal and systemic responses to L-arg after ACE inhibitor and AT1B were associated with a rise in plasma L-citrulline levels, which was greater than after control L-arg (P &lt; 0.05).	Arginine	41-46	angiotensin I converting enzyme	Homo sapiens	53-56
10678543-14	2000	CONCLUSION: The results indicate that ACE inhibitors and AT1B have a potential to enhance L-arg-induced vasodilation both in systemic and renal vascular beds.	Arginine	90-95	angiotensin I converting enzyme	Homo sapiens	38-41
10761688-8	2000	The catalase and Mn-SOD activities were significantly decreased throughout the study, while the GPx activity was significantly reduced at 6 and 12 h, and the Cu, Zn-SOD activity was significantly lower at 12 h after the Arg injection as compared with the controls.	Arginine	220-223	catalase	Rattus norvegicus	4-12
10744039-1	2000	An association between the Arg allele of the p21WAF1/CIP1 codon 31 polymorphism and lung cancer has been reported.	Arginine	27-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	53-57
11534124-1	2000	Nitric oxide (NO), which is synthesized from L-arginine by nitric oxide synthase (NOS) in mammals, acts as a signal molecule for vasorelaxation, cytotoxicity and neurotransmission.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	59-80
10647067-9	2000	L-Arginine was able to counteract the inhibitory effect of ET-1 on cGMP and GK activity.	Arginine	0-10	endothelin 1	Rattus norvegicus	59-63
11124577-6	2000	iNOS was measured by conversion of labeled arginine into citrulline by incubating MBH in the absence of calcium (Ca(2+)) since iNOS does not require Ca(2+) for activation.	Arginine	43-51	nitric oxide synthase 2	Rattus norvegicus	0-4
10737008-8	2000	Urinary sodium excretion and the NO2 + NO3 level were significantly increased following L-arginine infusion and the increment of fractional excretion of sodium was higher in responders.	Arginine	88-98	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
10631259-7	2000	This inhibitory sequence appears to overlap with a calmodulin-binding site in ACA2, previously mapped between aspartate-19 and arginine-36 (J.F.	Arginine	127-135	calmodulin	Saccharomyces cerevisiae S288C	51-61
11202226-7	2000	Arginine potentiates both spontaneous and GHRH-induced GH secretion to the same extent in normally growing children, adults and elderly individuals, indicating that the releasable pool of GH is generally preserved across the human life span.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	42-46
10765977-7	2000	L-arginine (the precursor of nitric oxide) and sodium nitroprusside (a nitric oxide donor) treatment of alloxan-induced diabetic rats enhanced the levels of LA, GLA and DGLA.	Arginine	0-10	galactosidase, alpha	Rattus norvegicus	161-164
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Arginine	50-58	cyclin T1	Homo sapiens	154-163
10608868-4	1999	Only four positions in loop 3 of uPAR domain I exhibited significant changes in the contribution to the free energy of uPA binding (DeltaDeltaG &gt;/= 1.3 kcal mol(-1)) upon single-site substitutions to alanine (i.e. Arg(53), Leu(55), Tyr(57), and Leu(66)).	Arginine	217-220	plasminogen activator, urokinase	Homo sapiens	33-36
10601317-4	1999	We mutated His(73) in yeast actin to Arg, Lys, Ala, Gln, and Glu and detected no altered phenotypes associated with the mutations in vivo.	Arginine	37-40	actin	Saccharomyces cerevisiae S288C	28-33
10601317-10	1999	It also predicts that Arg(73) tightens and stabilizes the actin and that Glu(73) causes a rearrangement of the bottom of actin"s interdomain cleft leading possibly to our observed destabilization of actin.	Arginine	22-25	actin	Saccharomyces cerevisiae S288C	58-63
10590083-0	1999	The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts.	Arginine	37-40	ETS variant transcription factor 6	Homo sapiens	53-57
10590083-4	1999	The reciprocal transcript ARG-ETV6 was also detected in the patient RNA by reverse transcriptase-polymerase chain reaction (RT-PCR), although at a lower expression level.	Arginine	26-29	ETS variant transcription factor 6	Homo sapiens	30-34
10599760-9	1999	CONCLUSIONS: The first arginine in DII/S4 and in DIV/S4 within the skeletal muscle sodium channel and the L-type calcium channel genie CACNA1S appear to be critical for normal function.	Arginine	23-31	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	135-142
10585456-2	1999	We have identified a natural mutation at the -30 amino acid position of the angiotensinogen signal peptide, in which an arginine is replaced by a proline (R-30P).	Arginine	120-128	angiotensinogen	Homo sapiens	76-91
10587466-3	1999	In the current study of the C isozyme of rabbit PFK, two arginine residues that can be aligned with important residues in the catalytic and allosteric binding sites of bacterial PFK and that are conserved in all eukaryotic PFKs were mutated.	Arginine	57-65	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	48-51
10587466-3	1999	In the current study of the C isozyme of rabbit PFK, two arginine residues that can be aligned with important residues in the catalytic and allosteric binding sites of bacterial PFK and that are conserved in all eukaryotic PFKs were mutated.	Arginine	57-65	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	178-181
10587466-7	1999	Mutation of Arg-481, homologous to an active site residue in bacterial PFK, prevented binding and allosteric activation by fructose 2,6-bisphosphate.	Arginine	12-15	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	71-74
10598618-2	1999	This impairment is prevented by treatment with inhibitors of NO synthase 2 (NOS2), including glucocorticoids and L-arginine analogs.	Arginine	113-123	nitric oxide synthase 2, inducible	Mus musculus	61-74
10598618-2	1999	This impairment is prevented by treatment with inhibitors of NO synthase 2 (NOS2), including glucocorticoids and L-arginine analogs.	Arginine	113-123	nitric oxide synthase 2, inducible	Mus musculus	76-80
10583392-7	1999	In the carboxylate state, the structure is characterized by a salt-bridge between Arg(-1) and Asp8, which we identified previously in the [Lys(-2)-Arg(-1)]-endothelin-1 peptide (KR-ET-1).	Arginine	82-85	endothelin 1	Homo sapiens	156-168
10601964-8	1999	Insulin secretion in response to arginine was decreased in affected MODY3 subjects.	Arginine	33-41	insulin	Homo sapiens	0-7
10601964-8	1999	Insulin secretion in response to arginine was decreased in affected MODY3 subjects.	Arginine	33-41	HNF1 homeobox A	Homo sapiens	68-73
10601964-12	1999	CONCLUSIONS: Beta-cell dysfunction in response to glucose and arginine is observed in affected and unaffected MODY3 subjects.	Arginine	62-70	HNF1 homeobox A	Homo sapiens	110-115
10567237-1	1999	The high-affinity interaction of integrin alpha5beta1 with the central cell-binding domain of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the tenth type III repeat) and a second site Pro-His-Ser-Arg-Asn (PHSRN) in the adjacent ninth type III repeat, which synergizes with RGD.	Arginine	124-127	fibronectin 1	Homo sapiens	94-105
10567237-1	1999	The high-affinity interaction of integrin alpha5beta1 with the central cell-binding domain of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the tenth type III repeat) and a second site Pro-His-Ser-Arg-Asn (PHSRN) in the adjacent ninth type III repeat, which synergizes with RGD.	Arginine	212-215	fibronectin 1	Homo sapiens	94-105
10567237-2	1999	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel peptidic ligand for alpha5beta1, identified by phage display, which blocks alpha5beta1-mediated cell adhesion to fibronectin.	Arginine	0-3	fibronectin 1	Homo sapiens	162-173
10567237-2	1999	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel peptidic ligand for alpha5beta1, identified by phage display, which blocks alpha5beta1-mediated cell adhesion to fibronectin.	Arginine	4-7	fibronectin 1	Homo sapiens	162-173
10599538-2	1999	A polymorphism at codon 192 (Gln/Arg) of the PON1 gene gives rise to two isoforms that differ in substrate-dependent activity.	Arginine	33-36	paraoxonase 1	Homo sapiens	45-49
10561591-8	1999	Lower affinities of Lys-Pro, Arg-Pro and Pro-Pro indicate that additional molecular factors affect their binding at PEPT1.	Arginine	29-32	solute carrier family 15 member 1	Homo sapiens	116-121
10583392-7	1999	In the carboxylate state, the structure is characterized by a salt-bridge between Arg(-1) and Asp8, which we identified previously in the [Lys(-2)-Arg(-1)]-endothelin-1 peptide (KR-ET-1).	Arginine	147-150	endothelin 1	Homo sapiens	156-168
10647890-2	1999	A common p53 polymorphism at codon-72 of exon 4 results in translation to either arginine or proline.	Arginine	81-89	tumor protein p53	Homo sapiens	9-12
10567656-12	1999	There was no difference in the distribution of p53 proline and arginine alleles between HPV-16-positive cervical carcinoma patients and local controls, and no influence on clinical outcome; however, there was a trend for an increased frequency of p53 arginine homozygotes among the 350T carcinoma patients.	Arginine	251-259	tumor protein p53	Homo sapiens	247-250
10695726-2	1999	We demonstrate that induction of iNOS in CGCs by bacterial lipopolysaccharide and pro-inflammatory cytokines results in cell death that was potentiated by excess L-arginine and inhibited by the selective iNOS inhibitor, 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine.	Arginine	162-172	nitric oxide synthase 2	Homo sapiens	33-37
10600405-0	1999	Nitric oxide and l-arginine cause an accumulation of utrophin at the sarcolemma: a possible compensation for dystrophin loss in Duchenne muscular dystrophy.	Arginine	17-27	utrophin	Mus musculus	53-61
10570056-8	1999	The antagonists [AcHis(1),D-Phe(2),Lys(15),Arg(16), Leu(27)]VIP(3-7)/GRF(8-27) and VIP(5-27) had comparable affinities for the wild-type receptors and for the two latter chimeras, supporting the hypothesis that these chimeras were properly folded but unable to reach the high-agonist-affinity, active receptor conformation in response to VIP binding.	Arginine	43-46	vasoactive intestinal peptide	Homo sapiens	60-63
10570058-6	1999	Both L-arginine (10 mM) and NOC-18 (0.3 mM) counteracted the stimulatory effect on hERG1 outward currents induced by the radical oxygen species-generating system FeSO(4) (25 microM)/ascorbic acid (50 microM; Fe/Asc).	Arginine	5-15	PYD and CARD domain containing	Homo sapiens	211-214
10600405-5	1999	We show that in adult normal and mdx mice (an animal model of Duchenne myopathy) treated with l-arginine, the substrate of nitric oxide synthase (NOS), a pool of utrophin localized at the membrane appeared and increased, respectively.	Arginine	94-104	utrophin	Mus musculus	162-170
10600405-6	1999	In normal and mdx myotubes in culture, l-arginine, nitric oxide (NO), or hydroxyurea increased utrophin levels and enhanced its membrane localization.	Arginine	39-49	utrophin	Mus musculus	95-103
10551826-4	1999	To characterize further the function of these two domains, we demonstrate in this report that the previously described major nuclear localization signal works together with Lys(305)-Arg(306) to form a bipartite and functional nuclear localization sequence (NLS) for p53 nuclear import.	Arginine	182-185	tumor protein p53	Homo sapiens	266-269
10580224-5	1999	One of the modulators of cytokine-induced bone resorption is nitric oxide (NO), a product of the action of NO synthase (NOS) on L -arginine to form NO.	Arginine	128-139	nitric oxide synthase 2	Homo sapiens	107-118
10567387-6	1999	Critical to this tripartite complex is the establishment of four noncovalent bonds, three that determine the nature of the ligand recognition process involving residues Arg(280) and Tyr(226) of the alpha-chain and residue Tyr(365) of the beta-chain, since mutations of either one of these residues resulted in a significant decrease in the association rate.	Arginine	169-172	Fc gamma receptor and transporter	Homo sapiens	198-209
10655721-1	1999	INTRODUCTION: Nitric oxide (NO) is produced by the action of NO synthase (NOS) using L-arginine as a substrate in various cells and found in air exhaled by humans.	Arginine	85-95	nitric oxide synthase 2	Homo sapiens	61-72
10548540-5	1999	Addition of t-BOC-lysine and human serum albumin increased the rate of formation of alpha-oxoaldehydes - except glyoxal and methylglyoxal concentrations were low with albumin, as expected from the high reactivity of glyoxal and methylglyoxal with arginine residues.	Arginine	247-255	albumin	Homo sapiens	41-48
10521292-5	1999	A cluster of missense mutations at arginine 225 (R225) identifies this residue as crucial for CBFA1 function.	Arginine	35-43	RUNX family transcription factor 2	Homo sapiens	94-99
10613097-2	1999	NO is normally produced in the endothelium from L-arginine by the constitutive isoform of the NO synthase (cNOS).	Arginine	48-58	nitric oxide synthase 3	Homo sapiens	107-111
10714366-3	1999	The mutations in Gs alpha involved the replacement of either arginine 201 with cysteine or histidine, or glutamine 227 with arginine or leucine.	Arginine	61-69	GNAS complex locus	Homo sapiens	17-25
10521782-4	1999	It also has been demonstrated that the process of regeneration is invariably accompanied by the up-regulation of nitric oxide synthase (NOS), the enzyme that catalyzes arginine to nitric oxide (NO) and that both neurohypophyseal regeneration, as well as migration and emergence of neuron-like cells upon the surface of the adjacent third cerebral ventricle, is associated with the up-regulation of NOS and increased expression of NO.	Arginine	168-176	nitric oxide synthase 2	Homo sapiens	113-134
10668183-6	1999	The presence of Phe in position 1 and Arg in position 8, appear to be instrumental to exclude NC from interacting with the opioid receptors.	Arginine	38-41	prepronociceptin	Homo sapiens	94-96
10889318-6	1999	Thus, the present study proposes two novel approaches for the preparation of high affinity, specific thrombin inhibitors: a novel S1 anchoring moiety in the already large family of arginine/amidine-based inhibitors, i.e., the SO(2)N=C(NH(2))(2) group, and novel non-peptidomimetic scaffolds obtained by incorporating alkyl-/aryl-substituted-pyridinium moieties in the hydrophobic binding site(s).	Arginine	181-189	coagulation factor II, thrombin	Homo sapiens	101-109
10889318-7	1999	The first one is important for obtaining bioavailable thrombin inhibitors, devoid of the high basicity of the commonly used arginine/amidine-based inhibitors, whereas the second one may lead to improved water solubility of such compounds due to facilitated salt formation as well as increased stability at hydrolysis (in vivo).	Arginine	124-132	coagulation factor II, thrombin	Homo sapiens	54-62
10545100-6	1999	By replacing two arginines conserved between Rab3 isoforms, we generated a mutant with a reduced affinity for calmodulin.	Arginine	17-26	RAB3A, member RAS oncogene family	Rattus norvegicus	45-49
10545100-8	1999	However, replacement of the two arginines abolished the ability of the GTP-bound form of Rab3 to inhibit exocytosis of catecholamine- and insulin-secreting cells.	Arginine	32-41	RAB3A, member RAS oncogene family	Rattus norvegicus	89-93
10564709-3	1999	The kinetic analysis of L-arginine uptake in the presence of Na+ revealed that the process is mediated by saturable components: a high-affinity system (Km = 167 +/- 18.0 microM; Vmax = 0.174 +/- 0.012 micromol min-1) and a low-affinity carrier (Km = 980 +/- 112 microM; Vmax = 1.60 +/- 0.12 micromol min-1).	Arginine	24-34	CD59 molecule (CD59 blood group)	Homo sapiens	210-215
10564709-3	1999	The kinetic analysis of L-arginine uptake in the presence of Na+ revealed that the process is mediated by saturable components: a high-affinity system (Km = 167 +/- 18.0 microM; Vmax = 0.174 +/- 0.012 micromol min-1) and a low-affinity carrier (Km = 980 +/- 112 microM; Vmax = 1.60 +/- 0.12 micromol min-1).	Arginine	24-34	CD59 molecule (CD59 blood group)	Homo sapiens	300-305
10564709-6	1999	Kinetic studies in placentae taken from aspirin-treated pregnancies showed that L-arginine is transported with a significantly higher affinity (Km = 42.5 +/- 5.7 microM), but with a lower capacity (Vmax = 0.064 +/- 0.003 micromol min-1) than in the non-treated group.	Arginine	80-90	CD59 molecule (CD59 blood group)	Homo sapiens	230-235
10645729-4	1999	ARS levels were very low in cells grown in the presence of NH4Cl and dramatically increased on agar medium deprived of any nitrogen source or containing nitrate, nitrite, urea, arginine or glutamine.	Arginine	177-185	uncharacterized protein	Chlamydomonas reinhardtii	0-3
10602296-1	1999	Nitric oxide (NO), which is generated in vivo through conversion of L-arginine to L-citrulline by NO synthase (NOS), mediates many physiological and pathophysiological processes.	Arginine	68-78	nitric oxide synthase 2	Homo sapiens	98-109
10566637-5	1999	In one allele, an undescribed G to C transversion in codon 217, which occurred at the last base of exon 5 and thus altered the splice donor site sequence, apparently resulted in a substitution of Arg to Thr (AGG to ACG: R217T), and in the other allele, a C to T transition in codon 218 caused a substitution of Ala to Val (GCG to GTG: A218V), which has been previously shown to abolish StAR activity.	Arginine	196-199	glucagon	Homo sapiens	323-326
10619020-6	1999	Importantly, conservative substitutions of acetylated lysines with nonacetylatable arginines impair the ability of MyoD to stimulate transcription and to induce muscle conversion indicating that acetylation of MyoD is functionally critical.	Arginine	83-92	myogenic differentiation 1	Homo sapiens	115-119
10619020-6	1999	Importantly, conservative substitutions of acetylated lysines with nonacetylatable arginines impair the ability of MyoD to stimulate transcription and to induce muscle conversion indicating that acetylation of MyoD is functionally critical.	Arginine	83-92	myogenic differentiation 1	Homo sapiens	210-214
10521461-3	1999	The data presented here indicate that the arginine-rich domain, when embedded in recombinant fragments of NS3, interacts with the catalytic site of protein kinase C (PKC) and inhibits the phosphorylation mediated by this enzyme in vitro and in vivo.	Arginine	42-50	proline rich transmembrane protein 2	Homo sapiens	166-169
10748917-0	1999	L-arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1 beta and NO synthase activity.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	97-106
10748917-2	1999	IL-1 beta induces the expression of the inducible isoform of NO synthase (iNOS), which use L-arginine as substrate to overproduce NO.	Arginine	91-101	interleukin 1 beta	Rattus norvegicus	0-9
10748917-2	1999	IL-1 beta induces the expression of the inducible isoform of NO synthase (iNOS), which use L-arginine as substrate to overproduce NO.	Arginine	91-101	nitric oxide synthase 2	Rattus norvegicus	74-78
10521461-5	1999	In contrast, a peptide corresponding to the arginine-rich domain (HCV (1487-1500)), despite also being a PKC inhibitor, did not influence the PKC shuttling process and was transported to the particulate fraction by the translocating kinase upon activation with tetradecanoylphorbol-13-acetate.	Arginine	44-52	proline rich transmembrane protein 2	Homo sapiens	105-108
10521461-3	1999	The data presented here indicate that the arginine-rich domain, when embedded in recombinant fragments of NS3, interacts with the catalytic site of protein kinase C (PKC) and inhibits the phosphorylation mediated by this enzyme in vitro and in vivo.	Arginine	42-50	proline rich transmembrane protein 2	Homo sapiens	148-164
10526251-9	1999	Direct sequencing of the albumin gene showed a guanine to adenosine transition in the second nucleotide of codon 218, resulting in a substitution of histidine (CAC) for the normal arginine (CGC) in one of the two alleles in the patient.	Arginine	180-188	albumin	Homo sapiens	25-32
10510054-1	1999	BACKGROUND: Endothelium-derived nitric oxide (NO) is synthesised from L-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS 3 gene on chromosome 7.	Arginine	70-80	nitric oxide synthase 3	Homo sapiens	84-117
10510054-1	1999	BACKGROUND: Endothelium-derived nitric oxide (NO) is synthesised from L-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS 3 gene on chromosome 7.	Arginine	70-80	nitric oxide synthase 3	Homo sapiens	140-145
10496984-12	1999	Collectively, our results demonstrate that conformation-dependent arginine-mediated ionic interactions are responsible for the TFPI-2/MSPI triplet binding to fibroblast ECM, heparin, and dermatan sulfate and that heparin augmented the rate of inhibition of plasmin by TFPI-2/MSPI.	Arginine	66-74	tissue factor pathway inhibitor 2	Homo sapiens	127-133
10496984-12	1999	Collectively, our results demonstrate that conformation-dependent arginine-mediated ionic interactions are responsible for the TFPI-2/MSPI triplet binding to fibroblast ECM, heparin, and dermatan sulfate and that heparin augmented the rate of inhibition of plasmin by TFPI-2/MSPI.	Arginine	66-74	tissue factor pathway inhibitor 2	Homo sapiens	268-274
10583317-1	1999	OBJECTIVE: We tested the possibility that lysine vasopressin (LVP) changes the GH responsiveness to exogenously administered GH-RH (at its minimal and maximal doses), clonidine (which is thought to stimulate endogenous GH-RH release) and arginine (which is thought to inhibit somatostatin) in patients with type 1 diabetes mellitus and normal subjects.	Arginine	238-246	arginine vasopressin	Homo sapiens	49-60
10479735-4	1999	In the present paper we describe the synthesis, biological evaluation, and conformational characterization of two point-mutated PTH/PTHrP 1-34 hybrids in which the arginine residues at positions 19 and 21 of the native sequence of PTHrP have been replaced by valine (hybrid V(21)) and glutamic acid (hybrid E(19)), respectively, taken from the PTH sequence.	Arginine	164-172	parathyroid hormone	Homo sapiens	128-131
10479735-4	1999	In the present paper we describe the synthesis, biological evaluation, and conformational characterization of two point-mutated PTH/PTHrP 1-34 hybrids in which the arginine residues at positions 19 and 21 of the native sequence of PTHrP have been replaced by valine (hybrid V(21)) and glutamic acid (hybrid E(19)), respectively, taken from the PTH sequence.	Arginine	164-172	parathyroid hormone	Homo sapiens	132-135
10521252-12	1999	The [Gly(1),Arg(19)]hPTH-(1-28) analogue, in particular, should prove useful in dissociating AC- from PLC-dependent actions of PTH.	Arginine	12-15	parathyroid hormone	Homo sapiens	21-24
10514281-1	1999	The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurodegenerative disease states.	Arginine	71-81	nitric oxide synthase 2	Homo sapiens	14-36
10514288-2	1999	The same modification was performed on the potent bradykinin B(2) receptor antagonist HOE 140 (H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH), in which the -D-Tic-Oic- moiety was replaced by D-BT to yield H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-BT-Arg-OH, 1 (JMV1116).	Arginine	99-102	kininogen 1	Homo sapiens	50-60
10496984-0	1999	Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin.	Arginine	124-132	tissue factor pathway inhibitor 2	Homo sapiens	23-56
10496984-0	1999	Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin.	Arginine	124-132	tissue factor pathway inhibitor 2	Homo sapiens	102-108
10496984-0	1999	Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin.	Arginine	124-132	tissue factor pathway inhibitor 2	Homo sapiens	232-238
10496984-8	1999	Binding of TFPI-2/MSPI to GAGs was inhibited by NaCl or arginine but not by glucose, mannose, galactose, 6-aminohexanoic acid, or urea, suggesting that arginine-mediated ionic interactions participate in the GAG binding of TFPI-2/MSPI.	Arginine	56-64	tissue factor pathway inhibitor 2	Homo sapiens	11-17
10496984-8	1999	Binding of TFPI-2/MSPI to GAGs was inhibited by NaCl or arginine but not by glucose, mannose, galactose, 6-aminohexanoic acid, or urea, suggesting that arginine-mediated ionic interactions participate in the GAG binding of TFPI-2/MSPI.	Arginine	152-160	tissue factor pathway inhibitor 2	Homo sapiens	11-17
10496984-9	1999	This supposition was supported by the observation that only NaCl or arginine could elute the TFPI-2/MSPI protein triplet from an ECM derived from human dermal fibroblasts.	Arginine	68-76	tissue factor pathway inhibitor 2	Homo sapiens	93-99
10695765-0	1999	Fibrinogen Bbeta14 Arg--&gt;Cys: further evidence for a role in thrombosis.	Arginine	19-22	fibrinogen beta chain	Homo sapiens	0-10
10508155-6	1999	The catalytic domains of Gyp1p and Gyp7p contain five invariant arginine residues; substitutions of only one of them (R343 in Gyp1p and R458 in the analogous position of Gyp7p) rendered the GAPs almost completely inactive.	Arginine	64-72	GTPase-activating protein GYP1	Saccharomyces cerevisiae S288C	25-30
10491201-7	1999	Replacement of the His6 residue of alpha-MSH-ND by Gln, Asn, Arg or Lys decreased not only the receptor binding, but also the cAMP-generating activity in both the MC3R and the MC4R.	Arginine	61-64	melanocortin receptor 3	Cricetulus griseus	163-167
10506585-13	1999	Using the PARP inhibitor 3-aminobenzamide, we established that PARP determines both cell lysis and DNA damage induced by UVA and/or L-Arg.	Arginine	132-137	poly(ADP-ribose) polymerase 1	Homo sapiens	10-14
10506585-13	1999	Using the PARP inhibitor 3-aminobenzamide, we established that PARP determines both cell lysis and DNA damage induced by UVA and/or L-Arg.	Arginine	132-137	poly(ADP-ribose) polymerase 1	Homo sapiens	63-67
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Arginine	67-70	tachykinin precursor 1	Homo sapiens	243-261
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Arginine	67-70	tachykinin precursor 1	Homo sapiens	392-410
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Arginine	94-97	tachykinin precursor 1	Homo sapiens	243-261
10525358-4	1999	A peptide with neurokinin A-like immunoreactivity (Ser-Ser-Ala-Asn-Arg-Gln-Ile-Thr-Gly-Lys(10)Arg-Gln-Lys-Ile-Asn-Ser-P he-Val-Gly-Leu(20)Met.NH(2)) was isolated from sturgeon brain and contains 10 amino acid substitutions compared with human neuropeptide gamma (a specific product of the posttranslational processing of gamma-preprotachykinin A) but only 4 substitutions compared with trout neuropeptide gamma.	Arginine	94-97	tachykinin precursor 1	Homo sapiens	392-410
10502786-4	1999	Genomic DNA was extracted and denaturinggradient gel electrophoresis of exon 7 of the androgen receptor gene followed by sequence analysis revealed a new mutation, a C A transversion, altering codon 840 from arginine (CGT) to serine (AGT).	Arginine	208-216	androgen receptor	Homo sapiens	86-103
10490974-1	1999	Activated murine macrophages metabolize arginine by two alternative pathways involving the enzymes inducible NO synthase (iNOS) or arginase.	Arginine	40-48	nitric oxide synthase 2, inducible	Mus musculus	99-120
10502786-4	1999	Genomic DNA was extracted and denaturinggradient gel electrophoresis of exon 7 of the androgen receptor gene followed by sequence analysis revealed a new mutation, a C A transversion, altering codon 840 from arginine (CGT) to serine (AGT).	Arginine	208-216	angiotensinogen	Homo sapiens	234-237
10497157-3	1999	By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding.	Arginine	110-113	ATP binding cassette subfamily C member 8	Rattus norvegicus	30-34
10509673-5	1999	A heterozygous base change was found, resulting in the substitution of an arginine to a stop at codon 152 of the ABCR gene.	Arginine	74-82	ATP binding cassette subfamily A member 4	Homo sapiens	113-117
10490974-1	1999	Activated murine macrophages metabolize arginine by two alternative pathways involving the enzymes inducible NO synthase (iNOS) or arginase.	Arginine	40-48	nitric oxide synthase 2, inducible	Mus musculus	122-126
10488098-3	1999	Mutant D, with changes at Arg(184), Lys(185), Arg(189), Arg(192), Arg(193), demonstrated a approximately 130-fold increased rate of thrombin inactivation that was unaffected by the presence of glycosaminoglycans.	Arginine	26-29	coagulation factor II, thrombin	Homo sapiens	132-140
10504630-9	1999	Conversely, supplementing the cardioplegic solution with a 10 mmol/L dose of L-arginine (group 3) negated these beneficial effects, resulting in depressed systolic function (end-systolic elastance 41% +/- 2%; P &lt;.001 vs 4 mmol/L L-arginine) and preload recruitable stroke work (40% +/- 2%; P &lt;.001 vs 4 mmol/L L-arginine); increased diastolic stiffness (246% +/- 7%; P &lt;.001 vs 4 mmol/L L-arginine); and higher conjugated diene production, myeloperoxidase activity, and coronary vascular resistance (P &lt;.001 vs 4 mmol/L L-arginine in each case).	Arginine	77-87	myeloperoxidase	Homo sapiens	449-464
10545044-2	1999	The patient was heterozygous for a G-to-A substitution at codon 524 (R524Q), changing an encoded arginine (CGA) to glutamine (CAA), while the GBE1 gene on the other allele was not expressed.	Arginine	97-105	chromogranin A	Homo sapiens	107-110
10449610-0	1999	p53 codon 72 ARG/PRO polymorphism is not related to HPV type or lesion grade in low- and high-grade squamous intra-epithelial lesions and invasive squamous carcinoma of the cervix.	Arginine	13-16	tumor protein p53	Homo sapiens	0-3
10449610-1	1999	A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells.	Arginine	67-75	tumor protein p53	Homo sapiens	34-37
10449610-1	1999	A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells.	Arginine	67-75	tumor protein p53	Homo sapiens	163-166
10534441-7	1999	However, when l-arginine level is higher than 2 x 10(-4) M, as observed under in vivo conditions, NOS-III activity is essentially unaffected by temperature, the substrate concentration exceeding the value of K(m).	Arginine	14-24	nitric oxide synthase 3	Homo sapiens	98-105
10518318-0	1999	Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.	Arginine	0-8	fragile X messenger ribonucleoprotein 1	Homo sapiens	92-96
10518318-4	1999	A novel missense mutation, which changes an arginine to a histidine in the RGG box region of FMRP in a typical fragile X patient, has been identified.	Arginine	44-52	fragile X messenger ribonucleoprotein 1	Homo sapiens	93-97
10488098-3	1999	Mutant D, with changes at Arg(184), Lys(185), Arg(189), Arg(192), Arg(193), demonstrated a approximately 130-fold increased rate of thrombin inactivation that was unaffected by the presence of glycosaminoglycans.	Arginine	46-49	coagulation factor II, thrombin	Homo sapiens	132-140
10488098-3	1999	Mutant D, with changes at Arg(184), Lys(185), Arg(189), Arg(192), Arg(193), demonstrated a approximately 130-fold increased rate of thrombin inactivation that was unaffected by the presence of glycosaminoglycans.	Arginine	46-49	coagulation factor II, thrombin	Homo sapiens	132-140
10488098-3	1999	Mutant D, with changes at Arg(184), Lys(185), Arg(189), Arg(192), Arg(193), demonstrated a approximately 130-fold increased rate of thrombin inactivation that was unaffected by the presence of glycosaminoglycans.	Arginine	46-49	coagulation factor II, thrombin	Homo sapiens	132-140
10480873-3	1999	To measure this moesin-specific activity, a nonradioactive enzyme-linked immunosorbent assay method was developed with the synthetic peptide Cys-Lys(555)-Tyr-Lys-Thr(P)-Leu-Arg(560) coupled to bovine serum albumin as the substrate and moesin phosphorylation state-specific polyclonal antibodies for the detection and quantitation of dephosphorylation.	Arginine	173-176	moesin	Homo sapiens	16-22
10505651-4	1999	Under L-arginine deprivation and IL-1beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-argininemethyl-ester.	Arginine	6-16	interleukin 1 beta	Rattus norvegicus	33-41
10556586-7	1999	Amounts of NO synthesised by monocytes co-expressing iNOS and arginase changed with the addition of arginine or an iNOS inhibitor; in that case a correlation of NO production and apoptotic features was observed.	Arginine	100-108	nitric oxide synthase 2	Homo sapiens	53-57
10556586-8	1999	Data suggest a regulatory role for endogenous NO in apoptosis of stimulated and differentiated monocytes, and also that iNOS and A-II, when simultaneously present, could control the production of NO as a consequence of their competition for arginine.	Arginine	241-249	nitric oxide synthase 2	Homo sapiens	120-124
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Arginine	149-152	coagulation factor II, thrombin	Homo sapiens	106-114
10489340-5	1999	Mutation of a conserved arginine in the polyproline helix abrogated more completely Nef-mediated enhancement of viral infectivity; this mutation also adversely affected CD4 downregulation at low levels of Nef expression.	Arginine	24-32	S100 calcium binding protein B	Homo sapiens	84-87
10489340-5	1999	Mutation of a conserved arginine in the polyproline helix abrogated more completely Nef-mediated enhancement of viral infectivity; this mutation also adversely affected CD4 downregulation at low levels of Nef expression.	Arginine	24-32	S100 calcium binding protein B	Homo sapiens	205-208
10507485-8	1999	Proinsulin-like molecule secretion seemed higher in cryopreserved than in fresh islets in response to all secretagogues used, and the difference was statistically significant for arginine.	Arginine	179-187	insulin	Homo sapiens	0-10
10464242-0	1999	L-arginine binding to nitric-oxide synthase.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	22-43
10464242-2	1999	Nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to nitric oxide and L-citrulline.	Arginine	55-65	nitric oxide synthase 2	Homo sapiens	0-21
10556566-2	1999	Cleavage of the Arg(561)-Val(562) activation site in plasminogen by either tissue- or urokinase-type plasminogen activator results in formation of the fibrinolytic enzyme plasmin.	Arginine	16-19	plasminogen activator, urokinase	Homo sapiens	86-122
10556575-0	1999	Corrigendum to: "Exposure of the cryptic arg-gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase".	Arginine	41-44	thrombospondin 1	Homo sapiens	65-81
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Arginine	176-179	coagulation factor II, thrombin	Homo sapiens	106-114
10464282-2	1999	Comparison of protein C activation in the presence and absence of TM identified 11 residues mediating the thrombin-TM interaction (Lys(21), Gln(24), Arg(62), Lys(65), His(66), Arg(68), Thr(69), Tyr(71), Arg(73), Lys(77), Lys(106)).	Arginine	176-179	coagulation factor II, thrombin	Homo sapiens	106-114
10477705-0	1999	Functional association of FcepsilonRIgamma with arginine(632) of paired immunoglobulin-like receptor (PIR)-A3 in murine macrophages.	Arginine	48-56	paired-Ig-like receptor A1	Mus musculus	65-100
10477705-0	1999	Functional association of FcepsilonRIgamma with arginine(632) of paired immunoglobulin-like receptor (PIR)-A3 in murine macrophages.	Arginine	48-56	paired-Ig-like receptor A1	Mus musculus	102-105
10477705-5	1999	This interaction is dependent on Arg(632) within the PIR-A3 transmembrane domain.	Arginine	33-36	paired-Ig-like receptor A1	Mus musculus	53-56
10469618-5	1999	It has recently been reported that the extent of p53 dysfunction caused by HPVs depends on the status of a polymorphism at codon 72 of p53, Pro or Arg.	Arginine	147-150	tumor protein p53	Homo sapiens	49-52
10498252-5	1999	This suppressor tRNA was expressed in xeroderma pigmentosum group A cells, containing a homozygous nonsense mutation at Arg-207 in the XPA complementing gene.	Arginine	120-123	XPA, DNA damage recognition and repair factor	Homo sapiens	135-138
10579646-4	1999	Hyperinsulinemia induced either by arginine or insulin injection was accompanied by increases in IGF-I plasma levels in brown trout (Salmo trutta).	Arginine	35-43	insulin like growth factor 1	Homo sapiens	97-102
10579646-6	1999	Administration of arginine in fasted fish led to a relative increase in insulin and IGF-I plasma concentrations, while arginine injection in fish previously treated with streptozotocin increased IGF-I levels only.	Arginine	18-26	insulin like growth factor 1	Homo sapiens	84-89
10579646-6	1999	Administration of arginine in fasted fish led to a relative increase in insulin and IGF-I plasma concentrations, while arginine injection in fish previously treated with streptozotocin increased IGF-I levels only.	Arginine	119-127	insulin like growth factor 1	Homo sapiens	195-200
10469010-6	1999	MEASUREMENTS: Twenty-four hour GH secretion, arginine-stimulated GH secretion, and fasting values of lipoproteins and triglycerides.	Arginine	45-53	growth hormone 1	Homo sapiens	65-67
10469010-20	1999	TC, LDL-C, and triglycerides also correlated significantly and negatively with arginine-stimulated GH secretion (peak GH) (TC vs. peak GH (r = - 0.	Arginine	79-87	growth hormone 1	Homo sapiens	99-101
10469010-20	1999	TC, LDL-C, and triglycerides also correlated significantly and negatively with arginine-stimulated GH secretion (peak GH) (TC vs. peak GH (r = - 0.	Arginine	79-87	growth hormone 1	Homo sapiens	118-120
10469010-20	1999	TC, LDL-C, and triglycerides also correlated significantly and negatively with arginine-stimulated GH secretion (peak GH) (TC vs. peak GH (r = - 0.	Arginine	79-87	growth hormone 1	Homo sapiens	118-120
10457392-1	1999	Nitric oxide is formed from L-arginine by a family of enzymes: nitric oxide synthase (NOS).	Arginine	28-38	nitric oxide synthase 2	Homo sapiens	63-84
10436179-5	1999	We demonstrate that particular homozygous genotypes of TNF-alpha and GM and KM allotypes epistatically interact with HLA-DQalpha1(Arg 52) and contribute to an increased relative risk of NIDDM.	Arginine	130-133	tumor necrosis factor	Homo sapiens	55-64
10487521-0	1999	Induction of apoptosis by the p53-273L (Arg --&gt; Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax.	Arginine	40-43	tumor protein p53	Homo sapiens	30-33
10425273-2	1999	A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix.	Arginine	67-75	tumor protein p53	Homo sapiens	30-33
10425273-2	1999	A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix.	Arginine	67-75	tumor protein p53	Homo sapiens	77-80
10425273-2	1999	A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix.	Arginine	156-164	tumor protein p53	Homo sapiens	30-33
10425273-2	1999	A polymorphism at codon 72 of p53 results in translation to either arginine (p53Arg) or proline (p53Pro), and recent study showed that Caucasian women with arginine form of p53 are more susceptible to HPV-associated carcinoma of the cervix.	Arginine	156-164	tumor protein p53	Homo sapiens	77-80
10473178-5	1999	Tumor necrosis factor-alpha (TNF-alpha) has been shown to stimulate the oxidative metabolism of L-arginine to produce NO.	Arginine	96-106	tumor necrosis factor	Mus musculus	0-27
10473178-5	1999	Tumor necrosis factor-alpha (TNF-alpha) has been shown to stimulate the oxidative metabolism of L-arginine to produce NO.	Arginine	96-106	tumor necrosis factor	Mus musculus	29-38
10487521-2	1999	We have previously reported that a mutation at codon 273, p53-273L (Arg --&gt; Leu), suppresses cell growth despite its having no p53-specific transactivation activity.	Arginine	68-71	tumor protein p53	Homo sapiens	58-61
10455184-5	1999	We also find that Arg-102 in the third repeat is likely involved in binding to Rac via an ionic interaction, and that replacement of this residue with Glu completely abrogates the capability of activating the oxidase both in vivo and in vitro.	Arginine	18-21	AKT serine/threonine kinase 1	Homo sapiens	79-82
10455137-1	1999	The nitric-oxide synthase (NOS) catalyzes the oxidation of L-arginine to L-citrulline and NO through consumption of oxygen bound to the heme.	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	4-25
10438506-3	1999	Molecular modeling of arachidonic acid in sheep COX-1 confirms that this L-shaped conformation is possible, with the carboxylate moiety binding to Arg-120 and the omega-end positioned above Ser-530 in a region termed the top channel.	Arginine	147-150	cytochrome c oxidase subunit I	Ovis aries	48-53
10464023-9	1999	Therefore, we attribute the high B1 receptor selectivity, observed upon removal of Arg(9) from bradykinin, solely to the loss of a charged amino acid and not to altered structural features.	Arginine	83-86	bradykinin receptor B1	Homo sapiens	33-44
10464023-9	1999	Therefore, we attribute the high B1 receptor selectivity, observed upon removal of Arg(9) from bradykinin, solely to the loss of a charged amino acid and not to altered structural features.	Arginine	83-86	kininogen 1	Homo sapiens	95-105
10480602-8	1999	Glucose potentiation of arginine-induced insulin secretion, the measure of insulin secretory reserve, correlated significantly (r = 0.095, P &lt; 0.001) with the acute insulin response to intravenous glucose, rendering the latter a much simpler and valid measure of functional beta-cell mass.	Arginine	24-32	insulin	Homo sapiens	41-48
10480602-8	1999	Glucose potentiation of arginine-induced insulin secretion, the measure of insulin secretory reserve, correlated significantly (r = 0.095, P &lt; 0.001) with the acute insulin response to intravenous glucose, rendering the latter a much simpler and valid measure of functional beta-cell mass.	Arginine	24-32	insulin	Homo sapiens	75-82
10690324-1	1999	Nitric oxide (NO) is synthesised from L-arginine by the enzyme NO synthase (NOS).	Arginine	38-48	nitric oxide synthase 2	Homo sapiens	63-74
10690326-1	1999	The guanidino-methylated arginine analogue NG monomethyl-L-arginine (L-NMMA) has been the standard nitric oxide synthase inhibitor used to evaluate the role of the L-arginine:nitric oxide pathway.	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	99-120
10690326-4	1999	Of the three known methylarginine residues produced in mammals only asymmetrically methylated forms (L-NMMA and asymmetric dimethylarginine (ADMA)) but not symmetrically methylated arginine (symmetric dimethylarginine (SDMA)) inhibit nitric oxide synthase (NOS).	Arginine	25-33	nitric oxide synthase 2	Homo sapiens	234-255
10417309-10	1999	The equivalent residue (position 136) in Drosophila CPT I is arginine, implying that any basic residue might be compatible with such sensitivity.	Arginine	61-69	withered	Drosophila melanogaster	52-57
10434007-2	1999	Supporting of this 10 min after the administration of L-Arginine (L-Arg) increased GABA concentration and diminished the activity of GABA-T.	Arginine	54-64	4-aminobutyrate aminotransferase	Rattus norvegicus	133-139
10434007-2	1999	Supporting of this 10 min after the administration of L-Arginine (L-Arg) increased GABA concentration and diminished the activity of GABA-T.	Arginine	54-59	4-aminobutyrate aminotransferase	Rattus norvegicus	133-139
10439474-0	1999	Arginine residue 120 of the human GABAA receptor alpha 1, subunit is essential for GABA binding and chloride ion current gating.	Arginine	0-8	gamma-aminobutyric acid type A receptor subunit alpha1	Homo sapiens	34-56
10491753-8	1999	Plasma insulin concentrations after raising glucose to 14 and more than 25 mmol/l and the insulin response to arginine at more than 25 mmol/l glucose were increased by dexamethasone in high insulin sensitivity (p &lt; 0.05) but not changed by dexamethasone in low insulin sensitivity.	Arginine	110-118	insulin	Homo sapiens	90-97
10468305-1	1999	Homozygous arginine at codon 72 (HA72) of p53 was found in 22% of normal cervices and 30.0% of cervical cancers and no significant difference was detected between normal and cervical cancer with or without HPV 16/18.	Arginine	11-19	tumor protein p53	Homo sapiens	42-45
10491753-8	1999	Plasma insulin concentrations after raising glucose to 14 and more than 25 mmol/l and the insulin response to arginine at more than 25 mmol/l glucose were increased by dexamethasone in high insulin sensitivity (p &lt; 0.05) but not changed by dexamethasone in low insulin sensitivity.	Arginine	110-118	insulin	Homo sapiens	90-97
10490782-10	1999	In addition, individuals found to simultaneously exhibit homozygosity of the common allele of all three polymorphisms (genotypes: Arg/Arg, pro/pro and II/II) exhibited significantly elevated fasting insulin levels (Pc = 0.03).	Arginine	130-133	insulin	Homo sapiens	199-206
10490782-10	1999	In addition, individuals found to simultaneously exhibit homozygosity of the common allele of all three polymorphisms (genotypes: Arg/Arg, pro/pro and II/II) exhibited significantly elevated fasting insulin levels (Pc = 0.03).	Arginine	134-137	insulin	Homo sapiens	199-206
10415025-10	1999	A small deletion (aa 1-46) in the N-terminal portion of LC-PTP or Arg to Ala substitutions at aa 41 and 42 resulted in the loss of ERK binding activity.	Arginine	66-69	mitogen-activated protein kinase 1	Homo sapiens	131-134
10443652-3	1999	GHRH plus arginine (ARG) is a more provocative test and is as sensitive as ITT provided that appropriate cut-off limits are assumed.	Arginine	20-23	growth hormone releasing hormone	Homo sapiens	0-4
10430617-3	1999	Carriers of the Arg(972) substitution are characterized by lower fasting insulin and C-peptide levels compared with non-carriers, suggesting that the Arg(972) IRS-1 variant may contribute to impairment of insulin secretion.	Arginine	16-19	insulin	Homo sapiens	73-80
10430617-3	1999	Carriers of the Arg(972) substitution are characterized by lower fasting insulin and C-peptide levels compared with non-carriers, suggesting that the Arg(972) IRS-1 variant may contribute to impairment of insulin secretion.	Arginine	150-153	insulin	Homo sapiens	73-80
10425452-8	1999	One potentially important deviation was noted: ovine BRS-3 possesses an arginine residue at position 294 instead of a histidine residue as found in all other BRS-3.	Arginine	72-80	bombesin receptor subtype-3	Ovis aries	53-58
10465111-5	1999	Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively.	Arginine	76-79	chromogranin A	Homo sapiens	71-74
10465111-5	1999	Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively.	Arginine	76-79	tumor protein p53	Homo sapiens	141-144
10465111-5	1999	Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively.	Arginine	89-92	tumor protein p53	Homo sapiens	141-144
10496544-4	1999	Arginine (Arg) infusion can augment GH secretion, but the efficacy of oral Arg to improve GH response to exercise has not been explored.	Arginine	0-8	growth hormone 1	Homo sapiens	36-38
10496544-4	1999	Arginine (Arg) infusion can augment GH secretion, but the efficacy of oral Arg to improve GH response to exercise has not been explored.	Arginine	0-3	growth hormone 1	Homo sapiens	36-38
10496544-4	1999	Arginine (Arg) infusion can augment GH secretion, but the efficacy of oral Arg to improve GH response to exercise has not been explored.	Arginine	10-13	growth hormone 1	Homo sapiens	36-38
10496544-5	1999	We investigated whether oral Arg increases GH secretion in young and old people at rest and during exercise.	Arginine	29-32	growth hormone 1	Homo sapiens	43-45
10496544-12	1999	When Arg was coadministered during exercise, GH release was not affected in either the young or old and appeared to be blunted in the young compared to the exercise only trial in the young.	Arginine	5-8	growth hormone 1	Homo sapiens	45-47
10496544-13	1999	CONCLUSION: Based upon these findings, we concluded that oral Arg does not stimulate GH secretion and may impair GH release during resistive exercise.	Arginine	62-65	growth hormone 1	Homo sapiens	113-115
10400721-5	1999	Substitution of Arg for Ser at E2 1 resulted in a significant reduction in the efficiency of PE2 cleavage, yielding virus particles containing a mixture of PE2 and mature E2.	Arginine	16-19	ETS2 repressor factor	Homo sapiens	93-96
10691295-1	1999	Nitric oxide (NO) is an unstable radical produced during the oxidative deamination catalyzed by NO synthase (NOS) that converts L-arginine to L-citrulline.	Arginine	128-138	nitric oxide synthase 2	Homo sapiens	96-107
10400721-5	1999	Substitution of Arg for Ser at E2 1 resulted in a significant reduction in the efficiency of PE2 cleavage, yielding virus particles containing a mixture of PE2 and mature E2.	Arginine	16-19	ETS2 repressor factor	Homo sapiens	156-159
10400740-0	1999	A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability.	Arginine	12-20	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	108-111
10400740-3	1999	p12(I) is ubiquitylated, and mutations of its unique carboxy-terminus lysine residue to an arginine greatly enhance its stability.	Arginine	91-99	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	0-3
10400740-4	1999	Interestingly, analysis of 53 independent HTLV-1 strains revealed that the natural p12(I) alleles found in ex vivo samples of tropical spastic paraparesis-HTLV-1-associated myelopathy patients contain a Lys at position 88 in some cases, whereas arginine is consistently found at position 88 in HTLV-1 strains from all adult T-cell leukemia-lymphoma (ATLL) cases and healthy carriers studied.	Arginine	245-253	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	83-86
10477180-2	1999	A novel nuclear serine/arginine (SR)-rich trypanosomal protein (TSR1) was characterized which contains two RNA recognition motifs.	Arginine	23-31	Tsr1p	Saccharomyces cerevisiae S288C	64-68
10419561-13	1999	In mutation mu1-N434R, containing the positively charged arginine, the potency of S(-)-bupivacaine was selectively decreased, resulting in a stereoselectivity (stereopotency ratio) of 3.	Arginine	57-65	glutathione S-transferase mu 1	Homo sapiens	12-15
10432380-15	1999	Furthermore, our data suggest that arginine-25 of apo E plays an important functional role by influencing the receptor-binding ability of apo E.	Arginine	35-43	apolipoprotein E	Homo sapiens	50-55
10432380-15	1999	Furthermore, our data suggest that arginine-25 of apo E plays an important functional role by influencing the receptor-binding ability of apo E.	Arginine	35-43	apolipoprotein E	Homo sapiens	138-143
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Arginine	66-69	mitogen-activated protein kinase kinase 4	Homo sapiens	51-55
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Arginine	66-69	mitogen-activated protein kinase 8	Homo sapiens	94-97
10409755-9	1999	Transient expression of a dominant negative mutant SEK1 (Lys--&gt;Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis.	Arginine	66-69	mitogen-activated protein kinase 8	Homo sapiens	125-128
10400673-4	1999	Identification of the two amino acids was achieved by dynamics-based docking of CCK in a refined three-dimensional model of CCK-AR using, as constraints, previous results that demonstrated that Trp-39/Gln-40 and Met-195/Arg-197 interact with the N terminus and the sulfated tyrosine of CCK, respectively.	Arginine	220-223	cholecystokinin	Homo sapiens	80-83
10488366-5	1999	Two RP patients were identified with disease-causing mutations in the rhodopsin gene: one from a black African family in which a codon 347 mutation resulted in a Pro-Leu substitution, and one in a family of Caucasian origin where a codon 58 alteration resulted in a Thr-Arg substitution.	Arginine	270-273	rhodopsin	Homo sapiens	70-79
10444369-1	1999	Expression of inducible nitric oxide (NO) synthase (iNOS) and related enzymes of arginine metabolism in the mouse lung exposed to filamentous fungus Fusarium kyushuense was studied by RNA blot, immunoblot, and histological analyses.	Arginine	81-89	nitric oxide synthase 2, inducible	Mus musculus	52-56
10400673-3	1999	Here we report on the identification of Arg-336 and Asn-333 of CCK-AR, which interact with the Asp-8 carboxylate and the C-terminal amide of CCK-9, respectively.	Arginine	40-43	cholecystokinin	Homo sapiens	63-66
10400673-4	1999	Identification of the two amino acids was achieved by dynamics-based docking of CCK in a refined three-dimensional model of CCK-AR using, as constraints, previous results that demonstrated that Trp-39/Gln-40 and Met-195/Arg-197 interact with the N terminus and the sulfated tyrosine of CCK, respectively.	Arginine	220-223	cholecystokinin	Homo sapiens	124-127
10400673-5	1999	Arg-336-Asp-8 and Asn-333-amide interactions were pharmacologically assessed by mutational exchange of Arg-336 and Asn-333 in the receptor or reciprocal elimination of the partner chemical functions in CCK.	Arginine	0-3	cholecystokinin	Homo sapiens	202-205
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Arginine	187-190	cholecystokinin	Homo sapiens	162-165
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Arginine	308-311	cholecystokinin	Homo sapiens	162-165
10369794-5	1999	Supplementation with arginine or OKG, but not glutamine, was able to counteract the DEX effect on TNFalpha secretion.	Arginine	21-29	tumor necrosis factor	Rattus norvegicus	98-106
10413516-9	1999	Results with this construct argue that CD4-mimicking molecules with surrogate structural elements for the Phe 43/Arg 59 components of CD4 are sufficient to elicit a similar gp120 conformational isomerization as expressed by CD4 itself.	Arginine	113-116	CD4 molecule	Homo sapiens	39-42
10413516-9	1999	Results with this construct argue that CD4-mimicking molecules with surrogate structural elements for the Phe 43/Arg 59 components of CD4 are sufficient to elicit a similar gp120 conformational isomerization as expressed by CD4 itself.	Arginine	113-116	CD4 molecule	Homo sapiens	134-137
10413516-9	1999	Results with this construct argue that CD4-mimicking molecules with surrogate structural elements for the Phe 43/Arg 59 components of CD4 are sufficient to elicit a similar gp120 conformational isomerization as expressed by CD4 itself.	Arginine	113-116	CD4 molecule	Homo sapiens	134-137
10377239-1	1999	The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind.	Arginine	53-56	transferrin	Homo sapiens	4-15
10377239-1	1999	The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind.	Arginine	53-56	transferrin	Homo sapiens	111-122
10413511-0	1999	An aspartate residue at the extracellular boundary of TMII and an arginine residue in TMVII of the gastrin-releasing peptide receptor interact to facilitate heterotrimeric G protein coupling.	Arginine	66-74	gastrin releasing peptide receptor	Homo sapiens	99-133
10417510-3	1999	NO is generated from arginine by NO synthase (NOS); the Ca2+-dependent neuronal isoform or nNOS (expressed by neurones and inhibited by the protein inhibitor of nNOS, PIN), is also expressed by cultured normal melanocytes and by all malignant melanoma (MM) cell lines.	Arginine	21-29	dynein light chain LC8-type 1	Homo sapiens	167-170
10369924-7	1999	The latter (IKBL+738) was present in multiple examples of the 7.1 haplotype [HLA-A3, B7, DR2 (DR15)] and resulted in a cysteine to arginine substitution in a predicted protein kinase C phosphorylation site.	Arginine	131-139	NFKB inhibitor like 1	Homo sapiens	12-16
10428170-11	1999	A five-nucleotide "AGGAA" deletion at codons 608 and 609 of the androgen receptor gene resulted in a missing arginine and lysine as well as a frameshift that introduced a stop codon 12 amino acid downstream from the mutation.	Arginine	109-117	androgen receptor	Homo sapiens	64-81
10411000-2	1999	In this study, NO production in human neutrophils activated by chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) was measured in the presence of L-arginine (L-Arg) and N(G)-hydroxy-L-arginine (OH-L-Arg), the precursor and intermediate amino acids in NO synthesis, respectively.	Arginine	162-172	formyl peptide receptor 1	Homo sapiens	124-128
10411000-3	1999	Incubation of fMLP-activated neutrophils with OH-L-Arg resulted in a production of nitrite, nitrate, and citrulline that was greater than with unstimulated neutrophils but was not inhibited by the NOS inhibitors L-NMMA and L-NIO or the cytochrome P450 inhibitor troleandomycin and was not seen when OH-L-Arg was replaced with L-Arg.	Arginine	49-54	formyl peptide receptor 1	Homo sapiens	14-18
10411000-2	1999	In this study, NO production in human neutrophils activated by chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) was measured in the presence of L-arginine (L-Arg) and N(G)-hydroxy-L-arginine (OH-L-Arg), the precursor and intermediate amino acids in NO synthesis, respectively.	Arginine	174-179	formyl peptide receptor 1	Homo sapiens	124-128
10439394-3	1999	This paper presents evidence that E. coli cells starved for Pi under aerobic conditions indeed maintain an active aerobic metabolism for about 3 d, which allows the complete degradation of exogenous nutrients such as arginine (metabolized probably to putrescine via the SpeA-initiated pathway) and glucose (metabolized notably to acetate), but cell viability is not significantly affected because of the protection afforded against ROS through the expression of the RpoS and LexA regulons.	Arginine	217-225	DNA repair system	Escherichia coli	475-479
10431034-2	1999	In addition to its effects when administered as a dietary supplement, the end-products of arginine metabolism by the enzymes arginase, arginine decarboxylase (ADC), and nitric oxide synthase (NOS) have been shown to play roles in wound healing, immune response, tumor biology, and the regulation of inflammation.	Arginine	90-98	nitric oxide synthase 2	Homo sapiens	169-190
10411705-2	1999	There are two common PON1 polymorphisms at position 55 (Leu-Met change) and 192 (Gln-Arg change) of the amino acid chain.	Arginine	85-88	paraoxonase 1	Homo sapiens	21-25
10445036-0	1999	Removal of multiple arginine-framed trafficking signals overcomes misprocessing of delta F508 CFTR present in most patients with cystic fibrosis.	Arginine	20-28	CF transmembrane conductance regulator	Homo sapiens	94-98
10463335-8	1999	The aortic relaxation to exogenous L-arginine was augmented by IL-1beta in all groups, while the relaxation sensitivity to L-arginine after induction by IL-1beta was enhanced by exercise in the obese but not in the lean rats.	Arginine	123-133	interleukin 1 beta	Rattus norvegicus	153-161
10435871-4	1999	Supplementing dietary L-arginine in renal diseases with increased iNOS expression appears to be detrimental and thus, may be harmful in immune-mediated human kidney disorders.	Arginine	22-32	nitric oxide synthase 2	Homo sapiens	66-70
10387100-4	1999	The protected sites are after arginines 3630 and 3637 on RYR1.	Arginine	30-39	ryanodine receptor 1	Homo sapiens	57-61
10395590-7	1999	Removal of arginine, proline, threonine, tryptophan or valine inhibited the stimulation of IGF-I expression that was induced by the combination of T3, DEX and GH (to 15, 6, 11, 16 and 16% of control, respectively, P &lt; 0.05), with significant decreases in GHR expression also observed in some cases.	Arginine	11-19	growth hormone receptor	Sus scrofa	258-261
10387054-1	1999	Lysyl-tRNA synthetase (LysRS), a class II enzyme whose major function is to provide Lys-tRNALys for protein synthesis, also catalyzes aminoacylation of tRNALys with arginine, threonine, methionine, leucine, alanine, serine, and cysteine.	Arginine	165-173	lysyl-tRNA synthetase 1	Homo sapiens	0-21
10387054-1	1999	Lysyl-tRNA synthetase (LysRS), a class II enzyme whose major function is to provide Lys-tRNALys for protein synthesis, also catalyzes aminoacylation of tRNALys with arginine, threonine, methionine, leucine, alanine, serine, and cysteine.	Arginine	165-173	lysyl-tRNA synthetase 1	Homo sapiens	23-28
10387012-3	1999	To further explore these homologies as well as provide insights into the mechanism of primase, we generated three mutants (R304K, R304Q, and R304A) of the p49 subunit at an arginine that is highly conserved between primase and the eukaryotic family X polymerases.	Arginine	173-181	DNA primase subunit 1	Homo sapiens	155-158
10405166-5	1999	Apoptosis induced by PTP-S2 in MCF7 cells was inhibited by cotransfection with mutant p53 (Arg-273 --&gt; His) but not by wild type p53.	Arginine	91-94	tumor protein p53	Homo sapiens	86-89
10358075-3	1999	The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), became phosphorylated when FKHR was cotransfected with either PKB or PDK1 (an upstream activator of PKB).	Arginine	78-81	AKT serine/threonine kinase 1	Homo sapiens	53-56
10358065-1	1999	Arg-120 is located near the mouth of the hydrophobic channel that forms the cyclooxygenase active site of prostaglandin endoperoxide H synthases (PGHSs)-1 and -2.	Arginine	0-3	prostaglandin-endoperoxide synthase 1	Homo sapiens	106-161
10358065-13	1999	Thus, Arg-120 is important for the time-dependent inhibition of hPGHS-2 by NS398 but not by DuP-697 or SC58125.	Arginine	6-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-71
10358075-3	1999	The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), became phosphorylated when FKHR was cotransfected with either PKB or PDK1 (an upstream activator of PKB).	Arginine	78-81	forkhead box O1	Homo sapiens	137-141
10358065-2	1999	Replacement of Arg-120 of ovine PGHS-1 with a glutamine increases the apparent Km of PGHS-1 for arachidonate by 1,000-fold (Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M., and Smith, W. L. (1996) J. Biol.	Arginine	15-18	prostaglandin-endoperoxide synthase 1	Homo sapiens	32-38
10358065-2	1999	Replacement of Arg-120 of ovine PGHS-1 with a glutamine increases the apparent Km of PGHS-1 for arachidonate by 1,000-fold (Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M., and Smith, W. L. (1996) J. Biol.	Arginine	15-18	prostaglandin-endoperoxide synthase 1	Homo sapiens	85-91
10358075-3	1999	The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), became phosphorylated when FKHR was cotransfected with either PKB or PDK1 (an upstream activator of PKB).	Arginine	78-81	AKT serine/threonine kinase 1	Homo sapiens	172-175
10358065-5	1999	This and other evidence indicate that the guanido group of Arg-120 forms an ionic bond with the carboxylate group of arachidonate and that this interaction is an important contributor to the overall strength of arachidonate binding to PGHS-1.	Arginine	59-62	prostaglandin-endoperoxide synthase 1	Homo sapiens	235-241
10358065-7	1999	Our data indicate that the guanido group of Arg-120 of hPGHS-2 interacts with arachidonate through a hydrogen bond rather than an ionic bond and that this interaction is much less important for arachidonate binding to PGHS-2 than to PGHS-1.	Arginine	44-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	55-62
10358075-3	1999	The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), became phosphorylated when FKHR was cotransfected with either PKB or PDK1 (an upstream activator of PKB).	Arginine	78-81	AKT serine/threonine kinase 1	Homo sapiens	172-175
10358065-7	1999	Our data indicate that the guanido group of Arg-120 of hPGHS-2 interacts with arachidonate through a hydrogen bond rather than an ionic bond and that this interaction is much less important for arachidonate binding to PGHS-2 than to PGHS-1.	Arginine	44-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	56-62
10358065-7	1999	Our data indicate that the guanido group of Arg-120 of hPGHS-2 interacts with arachidonate through a hydrogen bond rather than an ionic bond and that this interaction is much less important for arachidonate binding to PGHS-2 than to PGHS-1.	Arginine	44-47	prostaglandin-endoperoxide synthase 1	Homo sapiens	233-239
10339496-6	1999	Accordingly, significantly high levels of iNOS activity were shown, as detected by the L-arginine to L-citrulline conversion in appropriate assay conditions.	Arginine	87-97	nitric oxide synthase 2	Rattus norvegicus	42-46
10358065-9	1999	Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1.	Arginine	36-39	prostaglandin-endoperoxide synthase 1	Homo sapiens	47-60
10358065-9	1999	Thus, the results of our studies of Arg-120 of PGHS-1 and -2 imply that interactions involved in the binding of arachidonate to PGHS-1 and -2 are quite different and that residues within the hydrophobic cyclooxygenase channel must contribute more significantly to arachidonate binding to PGHS-2 than to PGHS-1.	Arginine	36-39	prostaglandin-endoperoxide synthase 1	Homo sapiens	47-53
10358065-11	1999	PGHS-2-specific inhibitors including NS398, DuP-697, and SC58125 had IC50 values for the R120Q mutant that were up to 1,000-fold less than those observed for native hPGHS-2; thus, the positively charged guanido group of Arg-120 interferes with the binding of these compounds.	Arginine	220-223	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-6
10362683-11	1999	These findings suggest that together CAT-1 and CAT-2B play an important role in providing substrate for high-output NO synthesis in vitro as well as in vivo and implicate a coordinated regulation of intracellular iNOS enzyme activity with membrane arginine transport.	Arginine	248-256	nitric oxide synthase 2	Rattus norvegicus	213-217
10362520-4	1999	2-D gel electrophoresis of RNase-treated yeast extracts allowed us to tentatively identify the glycine- and arginine-rich (GAR) domain-containing proteins Gar1, Nop1, Sbp1, and Npl3 as major methyl-acceptors based on their known isoelectric points and apparent molecular weights.	Arginine	108-116	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	155-159
10362520-4	1999	2-D gel electrophoresis of RNase-treated yeast extracts allowed us to tentatively identify the glycine- and arginine-rich (GAR) domain-containing proteins Gar1, Nop1, Sbp1, and Npl3 as major methyl-acceptors based on their known isoelectric points and apparent molecular weights.	Arginine	108-116	rRNA methyltransferase NOP1	Saccharomyces cerevisiae S288C	161-165
10378824-4	1999	The results showed that most pulmonary arteries had 1-50% of the endothelial cells showing positive signals for ET-1 expression in hypoxic rats, which was significantly suppressed by L-arg.	Arginine	183-188	endothelin 1	Rattus norvegicus	112-116
10370135-2	1999	It is generated from l-arginine by nitric oxide synthases (NOS), which come in three isoforms depending on the tissue of origin, namely inducible-NOS (iNOS in macrophages), endothelial-NOS (eNOS in endothelial cells) and neural-NOS (nNOS in neural cells).	Arginine	21-31	nitric oxide synthase 2, inducible	Mus musculus	136-149
10370135-2	1999	It is generated from l-arginine by nitric oxide synthases (NOS), which come in three isoforms depending on the tissue of origin, namely inducible-NOS (iNOS in macrophages), endothelial-NOS (eNOS in endothelial cells) and neural-NOS (nNOS in neural cells).	Arginine	21-31	nitric oxide synthase 2, inducible	Mus musculus	151-155
10346979-0	1999	Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells.	Arginine	28-36	interleukin 1 beta	Rattus norvegicus	0-17
10383102-8	1999	These results cannot be ascribed to the depletion of arginine the iNOS substrate since they can be reproduced even in the presence of an excess (10 mM) of exogenously added arginine.	Arginine	173-181	nitric oxide synthase 2	Homo sapiens	66-70
10346979-7	1999	Moreover, the accumulation of arginine was higher in IL-1beta-treated beta cells than in control cells.beta cells expressed mRNAs for the two y+CAT transporters CAT-2A and CAT-2B with no change in transporter expression after exposure to IL-1beta.	Arginine	30-38	interleukin 1 beta	Rattus norvegicus	53-61
10318856-5	1999	Transient transfection analysis revealed that, in addition to a role in transcription start site selection, human TFIIB residue Arg-66 performs a critical function in vivo that is bypassed in vitro.	Arginine	128-131	general transcription factor IIB	Homo sapiens	114-119
10368358-5	1999	There was a 40% reduction in plasma insulin during hyperglycemia (0-45 min) after LCD (peak: 118 +/- 18 vs. 71 +/- 14 microU/ml; P &lt; 0.05) and ET (69 +/- 14 vs. 41 +/- 7 microU/ml; P &lt; 0.05) and trends for reductions during arginine infusion and a high-fat drink.	Arginine	230-238	insulin	Homo sapiens	36-43
10372687-9	1999	A significant correlation was found between the GH peak after ARG+GHRH and IGF-I, osteocalcin, urinary Ntx levels, and the t score at the lumbar spine, but not that at the femoral neck level.	Arginine	62-65	insulin like growth factor 1	Homo sapiens	75-80
10395349-3	1999	There are two genetic polymorphisms in the DNA sequence encoding the leader sequence of the TGF-beta1 protein, located at codon 10 (either leucine or proline) and at codon 25 (either arginine or proline).	Arginine	183-191	transforming growth factor beta 1	Homo sapiens	92-101
10395349-15	1999	CONCLUSION: Homozygosity for arginine at codon 25 of the leader sequence of TGF-beta1 that correlates with higher TGF-b production in vitro, is associated with fibrotic lung pathology before lung transplantation and with the development of fibrosis in the graft.	Arginine	29-37	transforming growth factor beta 1	Homo sapiens	76-85
10395349-15	1999	CONCLUSION: Homozygosity for arginine at codon 25 of the leader sequence of TGF-beta1 that correlates with higher TGF-b production in vitro, is associated with fibrotic lung pathology before lung transplantation and with the development of fibrosis in the graft.	Arginine	29-37	transforming growth factor beta 1	Homo sapiens	76-81
10354274-2	1999	We hypothesized that increased availability of L-arginine (L-Arg) during mesangial cell lysis might provide iNOS with increased substrate leading to increased lysis, and that this increased lysis would be reflected in more severe fibrotic disease at day 6.	Arginine	47-57	nitric oxide synthase 2	Rattus norvegicus	108-112
10354274-2	1999	We hypothesized that increased availability of L-arginine (L-Arg) during mesangial cell lysis might provide iNOS with increased substrate leading to increased lysis, and that this increased lysis would be reflected in more severe fibrotic disease at day 6.	Arginine	59-64	nitric oxide synthase 2	Rattus norvegicus	108-112
10354274-18	1999	CONCLUSIONS: The results indicate that if given during disease induction, L-Arg supplementation can enhance iNOS-dependent tissue injury by providing increased substrate.	Arginine	74-79	nitric oxide synthase 2	Rattus norvegicus	108-112
10354274-20	1999	These data predict that in diseases with repeated iNOS-dependent tissue injury, L-Arg supplementation may produce cumulative increases in tissue fibrosis.	Arginine	80-85	nitric oxide synthase 2	Rattus norvegicus	50-54
10369752-1	1999	Three polymorphisms of the PKD2 (MIM 173910) gene in patients with autosomal dominant polycystic kidney disease are reported: (1) a substitution from ATT (isoleucine) to GTT (valine) at codon 452; (2) a substitution from CGG (arginine) to CAG (glutamine) at codon 848; and (3) a substitution from G to A in intron 4 of the gene.	Arginine	226-234	polycystin 2, transient receptor potential cation channel	Homo sapiens	27-31
10336644-7	1999	We conclude that somatic forms of ACE should be considered as alternatives to CPs for the removal of basic residues from some Arg/Lys-extended peptides.	Arginine	126-129	angiotensin I converting enzyme	Homo sapiens	34-37
10416126-1	1999	The hypothesis was tested that induction of arginase expression in macrophages (M phi) diminishes nitric oxide (NO) synthesis due to intracellular competition between arginase and inducible nitric oxide synthase (iNOS) for L-arginine (L-arg).	Arginine	223-233	nitric oxide synthase 2, inducible	Mus musculus	213-217
10416126-1	1999	The hypothesis was tested that induction of arginase expression in macrophages (M phi) diminishes nitric oxide (NO) synthesis due to intracellular competition between arginase and inducible nitric oxide synthase (iNOS) for L-arginine (L-arg).	Arginine	223-228	nitric oxide synthase 2, inducible	Mus musculus	213-217
10435851-5	1999	Taking into account the 3rd centile limit of normal response, the GH response to GHRH+ARG was reduced in 62.3% (33/53) of the obese patients, and 21.2% (7/33) of them had low IGF-I levels.	Arginine	86-89	insulin like growth factor 1	Homo sapiens	175-180
10330172-3	1999	We show here that TTP binding to the TNF-alpha ARE is dependent upon the integrity of both zinc fingers, since mutation of a single cysteine residue in either zinc finger to arginine severely attenuated the binding of TTP to the TNF-alpha ARE.	Arginine	174-182	tumor necrosis factor	Mus musculus	37-46
10330172-3	1999	We show here that TTP binding to the TNF-alpha ARE is dependent upon the integrity of both zinc fingers, since mutation of a single cysteine residue in either zinc finger to arginine severely attenuated the binding of TTP to the TNF-alpha ARE.	Arginine	174-182	tumor necrosis factor	Mus musculus	229-238
10379819-3	1999	In our conditions, L-arginine (at 100-6000 micromol/L) was able to influence the response of human platelets stimulated with adenosine 5-diphosphate and collagen both in PRP and in whole blood.	Arginine	19-29	prion protein	Homo sapiens	170-173
10318856-6	1999	Furthermore, although correct transcription start site selection is dependent upon an arginine residue at position 66 in human TFIIB, innate function in vivo is determined by the charge of the residue alone.	Arginine	86-94	general transcription factor IIB	Homo sapiens	127-132
10231541-12	1999	Thus, the results of this study are consistent with FA binding to I-FABP involving an initial interaction with Arg-56 followed by insertion of the FA, through the portal region, into the binding cavity and with a reversal of these steps for the dissociation reaction.	Arginine	111-114	fatty acid binding protein 2	Homo sapiens	66-72
10320661-2	1999	It had been generally accepted that NO is solely generated in biological tissues by specific nitric oxide synthases (NOS) which metabolize arginine to citrulline with the formation of NO.	Arginine	139-147	nitric oxide synthase 2	Homo sapiens	93-115
10224081-0	1999	Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.	Arginine	17-25	protein arginine methyltransferase 3	Homo sapiens	142-147
10224081-7	1999	Both PRMT1 and PRMT3 specifically methylated arginines in the C-terminal domain corresponding to the naturally modified sites.	Arginine	45-54	protein arginine methyltransferase 3	Homo sapiens	15-20
10235127-2	1999	This study was designed to determine whether exogenous L-arginine modulates stress-induced gastric mucosal lesions through NO production by either constitutive NO synthase (cNOS) or inducible NO synthase (iNOS) in gastric mucosal tissues.	Arginine	55-65	nitric oxide synthase 2	Rattus norvegicus	182-203
10334492-7	1999	A p53 mutation in codon 273 (CGT--&gt;TGT, Arg--&gt;Cys) was identified in the first biopsy and persisted throughout the course of the disease.	Arginine	43-46	tumor protein p53	Homo sapiens	2-5
10196377-5	1999	In the present paper we show that in one of these families Pro791 of dysferlin is changed to an Arg residue.	Arginine	96-99	dysferlin	Homo sapiens	69-78
10212169-7	1999	The magnitude of dilatation of stenoses and all segments of both "normal" and diseased coronaries was greater after L-arginine (p &lt; 0.05) but not D-arginine and substance P infusion, than it was after saline and substance P infusion.	Arginine	116-126	tachykinin precursor 1	Homo sapiens	215-226
10401710-15	1999	; 2) HEX did not show more specificity than GHRH+PD and ARG+EE; 3) the association of GHRH+PD with ARG+EE could yield the best results at lower costs, confirming these tests as first-line tools in evaluating GH secretion.	Arginine	99-102	growth hormone releasing hormone	Homo sapiens	86-90
10235127-4	1999	Preadministration of L-arginine (150 to 600 mg/kg intraperitoneally) attenuated the lesion development with prevention of increases in gastric mucosal nitrite/nitrate concentration and iNOS activity.	Arginine	21-31	nitric oxide synthase 2	Rattus norvegicus	185-189
10235127-6	1999	This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration.	Arginine	51-61	nitric oxide synthase 2	Rattus norvegicus	182-186
10235127-6	1999	This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration.	Arginine	51-61	nitric oxide synthase 2	Rattus norvegicus	246-250
10235127-7	1999	These results indicate that preadministered L-arginine protects against water immersion restraint stress-induced gastric mucosal lesions, possibly through restricted NO production by cNOS in gastric mucosal tissues, whereas postadministered L-arginine aggravates the stress-induced gastric mucosal lesions, possibly through excessive NO production by iNOS increasing in gastric mucosal tissues.	Arginine	44-54	nitric oxide synthase 2	Rattus norvegicus	351-355
10233432-0	1999	Homozygous Cys542--&gt;Arg substitution in GPIIIa in a Swiss patient with type I Glanzmann"s thrombasthenia.	Arginine	23-26	integrin subunit beta 3	Homo sapiens	43-49
10233432-5	1999	Nonradioactive PCR single-strand conformation polymorphism analysis followed by direct sequencing of PCR-amplified DNA fragments showed a homozygous point mutation (T to C) at nucleotide 1722 of GPIIIa cDNA and which led to a Cys542--&gt;Arg substitution in the GPIIIa protein.	Arginine	238-241	integrin subunit beta 3	Homo sapiens	195-201
10233432-5	1999	Nonradioactive PCR single-strand conformation polymorphism analysis followed by direct sequencing of PCR-amplified DNA fragments showed a homozygous point mutation (T to C) at nucleotide 1722 of GPIIIa cDNA and which led to a Cys542--&gt;Arg substitution in the GPIIIa protein.	Arginine	238-241	integrin subunit beta 3	Homo sapiens	262-268
10235127-2	1999	This study was designed to determine whether exogenous L-arginine modulates stress-induced gastric mucosal lesions through NO production by either constitutive NO synthase (cNOS) or inducible NO synthase (iNOS) in gastric mucosal tissues.	Arginine	55-65	nitric oxide synthase 2	Rattus norvegicus	205-209
10226945-4	1999	The other tumor (case 33) had a point mutation at codon 266, changing GGA to AGA and causing a substitution of glycine to arginine in the p53 protein.	Arginine	122-130	tumor protein p53	Homo sapiens	138-141
10374872-1	1999	Nitric oxide (NO) is a biological mediator which is synthesized from L-arginine by a family of nitric oxide synthases (NOS).	Arginine	69-79	nitric oxide synthase 2	Homo sapiens	95-117
10215633-2	1999	Functional iNOS (L-arginine-mediated relaxation) was induced in RA and CM tissues (but NOT in the LM preparation) over 2 to 5 h. iNOS induction was detected by immunocytochemistry in RA smooth muscle elements and in macrophage-like cells in CM.	Arginine	17-27	nitric oxide synthase 2	Rattus norvegicus	11-15
10215633-2	1999	Functional iNOS (L-arginine-mediated relaxation) was induced in RA and CM tissues (but NOT in the LM preparation) over 2 to 5 h. iNOS induction was detected by immunocytochemistry in RA smooth muscle elements and in macrophage-like cells in CM.	Arginine	17-27	nitric oxide synthase 2	Rattus norvegicus	129-133
10337858-7	1999	GH release in response to GHRP-2 and arginine was measured in the same eight subjects before and during prednisone therapy.	Arginine	37-45	growth hormone 1	Homo sapiens	0-2
10337858-8	1999	Before prednisone, peak GH levels in response to arginine and GHRP-2 were 8.8 +/- 2.8 and 80.8 +/- 21.2 microg/L.	Arginine	49-57	growth hormone 1	Homo sapiens	24-26
10337858-9	1999	During prednisone therapy, the peak GH level in response to arginine and to GHRP-2 was 20.1 +/- 8.3 and 71.3 +/- 18.4 microg/L, respectively.	Arginine	60-68	growth hormone 1	Homo sapiens	36-38
10326761-2	1999	TFPI-2 inhibits a variety of serine proteinases involved in coagulation and fibrinolysis through an arginine residue (R24) in its first Kunitz-type domain, which constitutes a putative P1 residue for the substrate recognition sites of these proteinases.	Arginine	100-108	tissue factor pathway inhibitor 2	Homo sapiens	0-6
10337858-11	1999	The time to the peak GH level during prednisone therapy occurred sooner for both arginine and GHRP-2.	Arginine	81-89	growth hormone 1	Homo sapiens	21-23
10337858-14	1999	GH release occurred earlier for both arginine and GHRP-2 during steroid treatment.	Arginine	37-45	growth hormone 1	Homo sapiens	0-2
10341419-5	1999	In Saccharomyces cerevisiae, Kex1p can cleave lysine and arginine residues from the C-terminus of peptides and proteins.	Arginine	57-65	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	29-34
10231580-8	1999	When expressed in cell culture DNT became phosphorylated on tyrosine, as did a mutant form of the receptor, containing an arginine residue in place of lysine within the predicted nucleotide binding site.	Arginine	122-130	doughnut on 2	Drosophila melanogaster	31-34
10350073-4	1999	Arg-90 and Arg-106 being the primary site of trypsinolysis of synthetic calmodulin are partially-protected in K75P and K75E mutants.	Arginine	0-3	calmodulin 1	Homo sapiens	72-82
10350073-4	1999	Arg-90 and Arg-106 being the primary site of trypsinolysis of synthetic calmodulin are partially-protected in K75P and K75E mutants.	Arginine	11-14	calmodulin 1	Homo sapiens	72-82
10212223-1	1999	Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.	Arginine	15-23	midkine	Homo sapiens	30-37
10094786-5	1999	Cleavage by NRD convertase at the Arg-Arg sequence results in an increase of fluorescence.	Arginine	34-37	nardilysin convertase	Homo sapiens	12-26
10094786-5	1999	Cleavage by NRD convertase at the Arg-Arg sequence results in an increase of fluorescence.	Arginine	38-41	nardilysin convertase	Homo sapiens	12-26
10230610-2	1999	These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.	Arginine	110-119	coagulation factor II, thrombin	Homo sapiens	136-144
10103056-11	1999	The presence of two dibasic sequences Arg-Arg and Lys-Arg at the N-terminus of the heavy chain indicate that one or more subtilisin-like endopeptidases are responsible for the processing of leydin.	Arginine	38-41	serine protease 12	Homo sapiens	190-196
10233365-5	1999	The sequence of complete erythrocyte AK-1 cDNA showed the presence of a nonsense homozygous mutation at codon 107 (CGA --> TGA, Arg --> Stop) in the siblings.	Arginine	128-131	adenylate kinase 1	Homo sapiens	37-41
10103056-11	1999	The presence of two dibasic sequences Arg-Arg and Lys-Arg at the N-terminus of the heavy chain indicate that one or more subtilisin-like endopeptidases are responsible for the processing of leydin.	Arginine	42-45	serine protease 12	Homo sapiens	190-196
10199767-0	1999	The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency.	Arginine	40-48	growth hormone 1	Homo sapiens	4-18
10199767-1	1999	The aim of the present study was to correlate the degree of the GH response to the combined arginine and GHRH (ARG+GHRH) test with clinical status in 157 adult hypopituitary patients and 35 healthy controls.	Arginine	111-114	growth hormone releasing hormone	Homo sapiens	105-109
10199767-12	1999	A significant multiple linear regression coefficient was found between the GH peak after ARG+GHRH and plasma IGF-I levels (t = 2.947; P &lt; 0.005), total cholesterol levels (t = -2.746; P &lt; 0.01), and disease duration (t = -2.397; P &lt; 0.05).	Arginine	89-92	insulin like growth factor 1	Homo sapiens	109-114
10199783-0	1999	Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine.	Arginine	134-142	insulin	Homo sapiens	82-92
10199767-13	1999	In conclusion, the results of the present study indicate that the degree of the GH response to ARG+GHRH is correlated with the severity of lipid profile abnormalities and substantiate the reliability of the ARG+GHRH test for the diagnosis of GHD in adults.	Arginine	95-98	growth hormone releasing hormone	Homo sapiens	211-215
10199783-6	1999	This activated state of the beta-cell population is also held responsible for its higher secretory responsiveness to 5 mmol/L arginine at a submaximal (5 mmol/L) glucose concentration (8-fold higher proinsulin levels than in the control population).	Arginine	126-134	insulin	Homo sapiens	199-209
10199767-13	1999	In conclusion, the results of the present study indicate that the degree of the GH response to ARG+GHRH is correlated with the severity of lipid profile abnormalities and substantiate the reliability of the ARG+GHRH test for the diagnosis of GHD in adults.	Arginine	207-210	growth hormone releasing hormone	Homo sapiens	99-103
10213181-3	1999	An examination of the mechanism of heparin neutralization and protamine toxicity suggests that the reversal of heparin anticoagulation may only require a small arginine-rich fragment of protamine to electrostatically dissociate antithrombin III from its binding to a specific pentasaccharide sequence in heparin.	Arginine	160-168	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	228-244
10075657-9	1999	The Ile-33 --&gt; Gln point mutant completely inhibited and Arg-38 --&gt; Gln and Ser-36 --&gt; Asp point mutants reduced neurogranin/CaM interactions.	Arginine	60-63	calmodulin 1	Homo sapiens	134-137
10321742-3	1999	It was found that a single mutation of Arg-306 resulted in the defect of p53 nuclear import.	Arginine	39-42	tumor protein p53	Homo sapiens	73-76
10037709-4	1999	Likewise, the rate of thrombin inhibition by the heparin-independent inhibitor, alpha1-antitrypsin Met358 --&gt; Arg, is decreased less than 2-fold in the presence of soluble fibrin and heparin.	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	22-30
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	113-116	kallikrein related peptidase 11	Homo sapiens	252-273
10360678-3	1999	Whereas the SERCA1 isoform shows an age-dependent loss of Cys and Arg, the SERCA2a isoform displays a loss of Cys but also a significant accumulation of 3-nitrotyrosine.	Arginine	66-69	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	12-18
10037709-4	1999	Likewise, the rate of thrombin inhibition by the heparin-independent inhibitor, alpha1-antitrypsin Met358 --&gt; Arg, is decreased less than 2-fold in the presence of soluble fibrin and heparin.	Arginine	113-116	serpin family A member 1	Homo sapiens	80-98
10037750-5	1999	In this study, we modeled glutamine, asparagine, and a common mutation arginine at amino acid 188 on the three-dimensional model of the Escherichia coli GALT-UMP protein crystal.	Arginine	71-79	galactose-1-phosphate uridylyltransferase	Homo sapiens	153-157
10189382-2	1999	On the other hand the factor V mutation (Arg 506) is frequently coinherited with the prothrombin 3"-untranslated region G20210A variant and there is increasing evidence that the co-segregated prothrombin variant is an additional risk factor for venous thromboembolism, contributing to thrombotic manifestations.	Arginine	41-44	coagulation factor II, thrombin	Homo sapiens	85-96
10072758-9	1999	CnB-binding peptides are negatively charged with clusters of hydrophobic residues rich in phenylalanine, whereas the CaM-binding peptides are positively charged and often contain an Arg/Lys-Trp motif.	Arginine	182-185	calmodulin 1	Homo sapiens	117-120
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Arginine	115-118	apolipoprotein A1	Homo sapiens	23-30
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Arginine	131-134	apolipoprotein A1	Homo sapiens	23-30
10202375-4	1999	MATERIALS AND METHODS: Apo A-I variants from heterozygous carriers of Lys-107--&gt;0, Lys-107--&gt;Met, Pro-3--&gt;Arg, Pro-4--&gt;Arg, Pro-165--&gt;Arg and Glu-198--&gt;Lys and the corresponding normal apo A-I were purified and then radioiodinated with 131I and 125I.	Arginine	131-134	apolipoprotein A1	Homo sapiens	23-30
10051470-10	1999	Significantly increased risk associated with the p53 genotype was observed only among smokers who were glutathione S-transferase-null (Pro/Pro vs. Arg/Arg: odds ratio = 6.46; 95% CI = 1.55-26.94).	Arginine	147-150	tumor protein p53	Homo sapiens	49-52
10051470-10	1999	Significantly increased risk associated with the p53 genotype was observed only among smokers who were glutathione S-transferase-null (Pro/Pro vs. Arg/Arg: odds ratio = 6.46; 95% CI = 1.55-26.94).	Arginine	151-154	tumor protein p53	Homo sapiens	49-52
10037750-16	1999	The substitution of arginine or asparagine at position 188 reduces hydrogen bonding and destabilizes UMP-GALT.	Arginine	20-28	galactose-1-phosphate uridylyltransferase	Homo sapiens	105-109
10211586-2	1999	In macrophages and polymorphonuclear leukocytes, which express inducible nitric oxide synthase (iNOS), L-canavanine is able to prevent the L-arginine-derived synthesis of nitric oxide (NO).	Arginine	139-149	nitric oxide synthase 2	Homo sapiens	96-100
10213871-2	1999	Since the pivotal demonstration in 1984 by Pierschbacher and Ruoslahti that cell adhesion mediated by fibronectin could be inhibited by the simple tripeptide, Arg-Gly-Asp (RGD), then number of other peptide sequences have been shown to recapitulate integrin-ligand interactions.	Arginine	159-162	fibronectin 1	Homo sapiens	102-113
10189382-2	1999	On the other hand the factor V mutation (Arg 506) is frequently coinherited with the prothrombin 3"-untranslated region G20210A variant and there is increasing evidence that the co-segregated prothrombin variant is an additional risk factor for venous thromboembolism, contributing to thrombotic manifestations.	Arginine	41-44	coagulation factor II, thrombin	Homo sapiens	192-203
9949161-2	1999	The MITF encoded by the mutant mi allele (mi-MITF) deletes 1 of 4 consecutive arginines in the basic domain.	Arginine	78-87	melanogenesis associated transcription factor	Mus musculus	4-8
10193871-3	1999	Furthermore, in these patients GH secretion is impaired in response to all traditional pharmacological stimuli acting at the hypothalamus (insulin-induced hypoglycaemia, arginine, galanin, L-dopa, clonidine, acute glucocorticoid administration) and to direct somatotrope stimulation by exogenous growth hormone releasing hormone (GHRH).	Arginine	170-178	growth hormone 1	Homo sapiens	31-33
10074942-1	1999	Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively.	Arginine	150-158	nitric oxide synthase 3	Homo sapiens	28-61
10074942-1	1999	Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively.	Arginine	150-158	nitric oxide synthase 2	Homo sapiens	79-92
10074942-1	1999	Crystal structures of human endothelial nitric oxide synthase (eNOS) and human inducible NOS (iNOS) catalytic domains were solved in complex with the arginine substrate and an inhibitor S-ethylisothiourea (SEITU), respectively.	Arginine	150-158	nitric oxide synthase 2	Homo sapiens	94-98
10203026-3	1999	DRB1*0106 is identical to DRB1*0101 except for two codons, 71 (AGG--&gt;GCG) and 86 (GGT--&gt;GTG), changing the encoded arginine to alanine and glycine to valine.	Arginine	121-129	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
10203026-3	1999	DRB1*0106 is identical to DRB1*0101 except for two codons, 71 (AGG--&gt;GCG) and 86 (GGT--&gt;GTG), changing the encoded arginine to alanine and glycine to valine.	Arginine	121-129	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
10203026-3	1999	DRB1*0106 is identical to DRB1*0101 except for two codons, 71 (AGG--&gt;GCG) and 86 (GGT--&gt;GTG), changing the encoded arginine to alanine and glycine to valine.	Arginine	121-129	glucagon	Homo sapiens	72-75
10026154-0	1999	Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR.	Arginine	40-48	CF transmembrane conductance regulator	Homo sapiens	84-88
10026154-2	1999	Arginine 347 in the sixth transmembrane domain of cystic fibrosis transmembrane conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations.	Arginine	0-8	CF transmembrane conductance regulator	Homo sapiens	50-101
10026154-2	1999	Arginine 347 in the sixth transmembrane domain of cystic fibrosis transmembrane conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations.	Arginine	0-8	CF transmembrane conductance regulator	Homo sapiens	103-107
10026154-9	1999	These data suggest that Arg-347 plays an important structural role in CFTR, at least in part by forming a salt bridge with Asp-924; cystic fibrosis-associated mutations disrupt this interaction.	Arginine	24-27	CF transmembrane conductance regulator	Homo sapiens	70-74
10221692-6	1999	Genetic analysis showed a point mutation on exon 3 in the DNA-binding domain of the AR gene resulting in a change of codon 607 CGA (arginine) to CAA (glutamine).	Arginine	132-140	androgen receptor	Homo sapiens	84-86
10331639-8	1999	Rt6 is predominately an ADP-ribosyltransferase enzyme as determined using simple guanidino compounds (e.g. arginine) as ribose acceptors.	Arginine	107-115	ADP-ribosyltransferase 2b	Rattus norvegicus	0-3
9949161-2	1999	The MITF encoded by the mutant mi allele (mi-MITF) deletes 1 of 4 consecutive arginines in the basic domain.	Arginine	78-87	melanogenesis associated transcription factor	Mus musculus	45-49
10396357-4	1999	Growth hormone status had previously been determined using an insulin tolerance test and arginine stimulation test.	Arginine	89-97	growth hormone 1	Homo sapiens	0-14
10102942-4	1999	In addition to large amounts of nitric oxide (NO), injurious peroxynitrite may be formed in the epithelium by the inducible nitric oxide synthase (iNOS), which is considered to elicit cytotoxicity by the generation of superoxide with reduced L-arginine availability.	Arginine	242-252	nitric oxide synthase 2	Homo sapiens	114-145
10102942-4	1999	In addition to large amounts of nitric oxide (NO), injurious peroxynitrite may be formed in the epithelium by the inducible nitric oxide synthase (iNOS), which is considered to elicit cytotoxicity by the generation of superoxide with reduced L-arginine availability.	Arginine	242-252	nitric oxide synthase 2	Homo sapiens	147-151
10102942-9	1999	Selective inhibitors of iNOS activity, as well as topical L-arginine, may therefore prove beneficial in inflammatory bowel disease by reducing the production of superoxide by iNOS, while only the former option may be expected to reduce diarrhoea in chronic inflammatory bowel disorders.	Arginine	58-68	nitric oxide synthase 2	Homo sapiens	175-179
10025918-12	1999	L-arginine (10 mM) reversed the inhibitory effect of L-NMA on NO production and blocked the increases in TGFbeta1.	Arginine	0-10	transforming growth factor beta 1	Homo sapiens	105-113
10021299-4	1999	A polymorphism in the WAF1 gene, a C-to-A transversion at codon 31 resulting in the change of a serine (Ser) to an arginine (Arg), is well known.	Arginine	115-123	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-26
10207510-0	1999	L-arginine-induced growth hormone secretion is not influenced by co-infusion of the nitric oxide synthase inhibitor N-monomethyl-L-arginine in healthy men.	Arginine	0-10	growth hormone 1	Homo sapiens	19-33
10207510-9	1999	Growth hormone secretion increased significantly during L-arginine infusion (P = &lt; 0.001) without any effect of L-NMMA (P = 0.848).	Arginine	56-66	growth hormone 1	Homo sapiens	0-14
10021299-4	1999	A polymorphism in the WAF1 gene, a C-to-A transversion at codon 31 resulting in the change of a serine (Ser) to an arginine (Arg), is well known.	Arginine	125-128	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-26
10021299-11	1999	This implies that these two parameters may be associated with a tendency to develop endometrial carcinomas in individuals carrying the codon 31 Arg allele of the WAF1 gene.	Arginine	144-147	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
9920509-7	1999	In competition experiments, LDL, apoE, polymers of lysine and arginine were all capable of preventing the lipase specific [125I]Lp(a) retention.	Arginine	62-70	apolipoprotein E	Homo sapiens	33-37
10023783-2	1999	Most recently, p53 protein containing an arginine residue in codon 72 was shown to be more effectively degraded by the E6 oncoprotein of human papillomavirus (HPV) than the corresponding proline isoform in cervical carcinoma cells.	Arginine	41-49	tumor protein p53	Homo sapiens	15-18
10075015-2	1999	IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine.	Arginine	85-95	interferon gamma	Mus musculus	0-9
10075015-2	1999	IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine.	Arginine	85-95	nitric oxide synthase 2, inducible	Mus musculus	70-74
10075015-2	1999	IFN-gamma-induced NO production in L929 cells was mediated through an iNOS-dependent L-arginine-NO pathway, since it was abrogated by a selective inhibitor of iNOS, aminoguanidine.	Arginine	85-95	nitric oxide synthase 2, inducible	Mus musculus	159-163
9916740-3	1999	To overcome this difficulty, the zymogen form of human C1r was stabilized by mutating the Arg in the Arg463-Ile464 bond to Gln.	Arginine	90-93	complement C1r	Homo sapiens	55-58
10093213-5	1999	The strongest intramolecular interaction appears to be a proton bridge between the guanidino groups of the N- and C-terminal arginines in bradykinin.	Arginine	125-134	kininogen 1	Homo sapiens	138-148
9891044-1	1999	The wild-type p53 protein exhibits a common polymorphism at amino acid 72, resulting in either a proline residue (p53Pro) or an arginine residue (p53Arg) at this position.	Arginine	128-136	tumor protein p53	Homo sapiens	14-17
10021945-1	1999	Photoactivatable analogs of the human thrombin receptor (PAR-1) antagonist, N-trans-cinnamoyl-p-fluoroPhe-p-guanidinoPhe-Leu-Arg-NH2 (BMS-197525), were prepared with benzophenone substitutions in the N-terminal, Leu, or Arg position.	Arginine	125-128	coagulation factor II thrombin receptor	Homo sapiens	57-62
10202979-2	1999	Nitric oxide (NO) is an important synaptic plasticity molecule generated by nitric oxide synthase (NOS) oxidation of a guanidino nitrogen of L-arginine.	Arginine	141-151	nitric oxide synthase 2	Homo sapiens	76-97
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Arginine	127-137	nitric oxide synthase 2	Homo sapiens	0-40
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Arginine	127-137	nitric oxide synthase 2	Homo sapiens	42-46
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Arginine	139-144	nitric oxide synthase 2	Homo sapiens	0-40
9873034-1	1999	Cytokine-inducible nitric oxide synthase (iNOS) is a homodimeric enzyme that generates nitric oxide (NO) and L-citrulline from L-arginine (L-Arg) and O2.	Arginine	139-144	nitric oxide synthase 2	Homo sapiens	42-46
9873034-3	1999	In both cells and purified systems, iNOS dimer assembly is promoted by H4B, L-Arg, and L-Arg analogs.	Arginine	76-81	nitric oxide synthase 2	Homo sapiens	36-40
9873034-3	1999	In both cells and purified systems, iNOS dimer assembly is promoted by H4B, L-Arg, and L-Arg analogs.	Arginine	87-92	nitric oxide synthase 2	Homo sapiens	36-40
10194554-5	1999	To determine the presence of arginase and its specificity for ARG and CAV in MIA PaCa-2 cells, a radiometric assay, which quantifies the 14C released from the hydrolytic cleavage of L-[guanidino-14C]ARG or L-[guanidinooxy-14C]CAV mediated by arginase, was employed.	Arginine	62-65	MIA SH3 domain containing	Homo sapiens	77-80
10090484-8	1999	Two patients carried the mutation R3500Q (Arg--&gt;Glu) within the apoB-100 gene.	Arginine	42-45	apolipoprotein B	Homo sapiens	67-75
10051127-18	1999	These results suggest that in MCAs: (1) the induction of iNOS participates in the L-Arg relaxation and modulates the contraction to PGF2alpha; (2) that induction is partially mediated by a PKC-dependent mechanism; and (3) the involvement of iNOS in such responses is greater in the hypertensive strain.	Arginine	82-87	nitric oxide synthase 2	Rattus norvegicus	57-61
10051127-18	1999	These results suggest that in MCAs: (1) the induction of iNOS participates in the L-Arg relaxation and modulates the contraction to PGF2alpha; (2) that induction is partially mediated by a PKC-dependent mechanism; and (3) the involvement of iNOS in such responses is greater in the hypertensive strain.	Arginine	82-87	nitric oxide synthase 2	Rattus norvegicus	241-245
10225001-0	1999	L-arginine metabolites regulate DNA synthesis and nitric oxide synthase activity in cultured human dermal microvascular endothelial cells--potential positive and negative regulators of angiogenesis derived from L-arginine.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	50-71
10476613-3	1999	During cesarean section, biopsies from the uterine placental bed and the placenta were taken and the nitric oxide synthase (NOS) activity was measured by the [3H] L-arginine-[3H] L-citrulline conversion assay in these samples.	Arginine	163-173	nitric oxide synthase 2	Homo sapiens	101-122
10051127-0	1999	Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats.	Arginine	53-63	nitric oxide synthase 2	Rattus norvegicus	8-12
10094551-5	1999	Patient 1 carried a missense point mutation in exon 8 (ZF2), converting a CGA-Arg codon to a TGA-stop codon.	Arginine	78-81	zinc finger protein 274	Homo sapiens	55-58
9892165-1	1999	Inhibition of nitric oxide synthase by L-arginine analogues was shown to attenuate the antihypertensive effect of angiotensin II (AngII) type-1 receptor blockade, thus suggesting that nitric oxide might partly mediate the systemic effect of these agents.	Arginine	39-49	angiotensinogen	Rattus norvegicus	130-135
10429361-6	1999	The EXT2 mutation identified in the SNU-OC15 family was a missense mutation at codon 85 of exon 2 (TGC-->CGC), resulting in an amino acid change from cysteine to arginine.	Arginine	162-170	exostosin glycosyltransferase 2	Homo sapiens	4-8
9880793-5	1999	US-1 had a typical Arg-Gly-Asp (RGD) sequence, which is responsible for blocking the binding of fibrinogen to the receptor.	Arginine	19-22	fibrinogen beta chain	Homo sapiens	96-106
10071480-12	1999	CONCLUSION: We conclude that growth hormone contributes to the late phase of L-arginine-induced, NO-mediated vasodilation.	Arginine	77-87	growth hormone 1	Homo sapiens	29-43
10442576-2	1999	In normal blood vessels, NO is synthesized from L-arginine by a constitutively expressed NO synthase (NOS III) in endothelial cells.	Arginine	48-58	nitric oxide synthase 3	Homo sapiens	102-109
10442577-0	1999	The role of nitric oxide in L-arginine-stimulated growth hormone release.	Arginine	28-38	growth hormone 1	Homo sapiens	50-64
10442577-4	1999	NO is generated from L-arginine catalyzed by the NO synthases (NOS), of which two constitutive and one inducible form exist.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	49-61
10071480-1	1999	BACKGROUND: L-arginine is the precursor of endogenous nitric oxide (NO) and a potent stimulator of pituitary growth hormone and pancreatic insulin secretion.	Arginine	12-22	growth hormone 1	Homo sapiens	109-123
9989468-5	1999	Both 7-nitroindazole and aminoguanidine significantly antagonized the increases of cNOS and iNOS activities measured by conversion of 3H-L-arginine to 3H-L-citrulline in the ventral spinal cord, and blocked the Dyn-induced increases of ncNOS-immunoreactivity in the ventral horn cells 4 h after i.t.	Arginine	134-147	nitric oxide synthase 2	Rattus norvegicus	92-96
10072711-3	1999	None of these autacoids play such a central role in the regulation of vascular tone and homeostasis as the primary EDRF, the free radical NO, which is generated via a live-electron oxidation of a guanidino nitrogen from L-arginine by an NO synthase (NOS).	Arginine	220-230	nitric oxide synthase 2	Homo sapiens	237-248
9932681-12	1999	Administration of L-arginine after trauma-hemorrhage, however, improved splenic and peritoneal macrophage IL-1beta and IL-6 release.	Arginine	18-28	interleukin 1 beta	Rattus norvegicus	106-114
10071789-1	1999	This presentation will trace the serendipitous discovery of novel vasopressin (VP) hypotensive agonists d(CH2)5[D-Tyr(Et)2,X3]VAVP (where X = Arg, Lys).	Arginine	142-145	arginine vasopressin	Homo sapiens	66-77
10071789-1	1999	This presentation will trace the serendipitous discovery of novel vasopressin (VP) hypotensive agonists d(CH2)5[D-Tyr(Et)2,X3]VAVP (where X = Arg, Lys).	Arginine	142-145	arginine vasopressin	Homo sapiens	79-81
9932681-12	1999	Administration of L-arginine after trauma-hemorrhage, however, improved splenic and peritoneal macrophage IL-1beta and IL-6 release.	Arginine	18-28	interleukin 6	Rattus norvegicus	119-123
9932681-13	1999	Moreover, the up-regulated plasma levels of IL-6 were attenuated by L-arginine administration.	Arginine	68-78	interleukin 6	Rattus norvegicus	44-48
9932681-14	1999	CONCLUSION: L-Arginine administration after trauma-hemorrhage significantly improves the depressed macrophage function, presumably by decreasing the increased plasma IL-6 levels and improving organ blood flow.	Arginine	12-22	interleukin 6	Rattus norvegicus	166-170
9932681-15	1999	Early enhancement of the depressed constitutive nitric oxide synthase activity by provision of L-arginine after trauma-hemorrhage, therefore, represents a novel and safe approach for improving the depressed immune function and decreasing plasma IL-6 levels under such conditions.	Arginine	95-105	interleukin 6	Rattus norvegicus	245-249
9858574-11	1999	A new arginine-rich nuclear localization sequence (NLS) in the N-terminal region of the 34-kDa FGF-2 was characterized and found to be similar to the NLS of human immunodeficiency virus type 1 Rev protein.	Arginine	6-14	fibroblast growth factor 2	Homo sapiens	95-100
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	122-125	coagulation factor II, thrombin	Homo sapiens	81-89
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	131-134	coagulation factor II, thrombin	Homo sapiens	81-89
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	131-134	coagulation factor II, thrombin	Homo sapiens	81-89
10097286-8	1999	The thrombin cleavage site Arg 1545 is kinetically less favored than the other two sites, and cleavage at this site is the last to occur during thrombin activation of factor V As a consequence of this, different activation intermediates exist that express different levels of procoagulant activity.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	4-12
10097286-8	1999	The thrombin cleavage site Arg 1545 is kinetically less favored than the other two sites, and cleavage at this site is the last to occur during thrombin activation of factor V As a consequence of this, different activation intermediates exist that express different levels of procoagulant activity.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	144-152
10097286-10	1999	It was found that factor V could be cleaved by thrombin at both Arg 709 and Arg 1018 and still work fully as a cofactor to APC, whereas cleavage at Arg 1545 completely abolished the anticoagulant activity of factor V. This suggests that the APC cofactor function of factor V depends on the B-domain remaining attached to the A3 domain.	Arginine	64-67	coagulation factor II, thrombin	Homo sapiens	47-55
10097286-10	1999	It was found that factor V could be cleaved by thrombin at both Arg 709 and Arg 1018 and still work fully as a cofactor to APC, whereas cleavage at Arg 1545 completely abolished the anticoagulant activity of factor V. This suggests that the APC cofactor function of factor V depends on the B-domain remaining attached to the A3 domain.	Arginine	76-79	coagulation factor II, thrombin	Homo sapiens	47-55
10097286-10	1999	It was found that factor V could be cleaved by thrombin at both Arg 709 and Arg 1018 and still work fully as a cofactor to APC, whereas cleavage at Arg 1545 completely abolished the anticoagulant activity of factor V. This suggests that the APC cofactor function of factor V depends on the B-domain remaining attached to the A3 domain.	Arginine	76-79	coagulation factor II, thrombin	Homo sapiens	47-55
9918769-1	1998	The gaseous signal molecule, nitric oxide (NO*), is generated enzymatically by NO synthase (NOS) from L-arginine.	Arginine	102-112	nitric oxide synthase 2	Homo sapiens	79-90
9873068-0	1998	Arginine to glutamine substitutions in the fourth module of Xenopus interphotoreceptor retinoid-binding protein.	Arginine	0-8	retinol binding protein 3 L homeolog	Xenopus laevis	68-111
10743698-2	1999	NO is synthesized from L-arginine by NO synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	37-48
11601009-4	1999	The latter p53 gene encoding protein contained an Arg--&gt;His substitution at the same position, and pBLuscript plasmid was used as control.	Arginine	50-53	tumor protein p53	Homo sapiens	11-14
9873068-4	1998	METHODS: To study the arginines in an individual module without the interference of ligand-binding activity elsewhere in the protein, we expressed in E. coli the fourth module of Xenopus IRBP by itself as a soluble thioredoxin fusion protein (X4IRBP).	Arginine	22-31	retinol binding protein 3 L homeolog	Xenopus laevis	187-191
9873068-13	1998	CONCLUSIONS: Our data suggest that the function of the conserved arginines in IRBP is fundamentally different from that of other retinoid-binding proteins.	Arginine	65-74	retinol binding protein 3 L homeolog	Xenopus laevis	78-82
11601009-10	1999	CONCLUSION: Codon 172 mutant (Arg--&gt;Leu) p53 genomic DNA exhibited a strong suppressive transfecting effects on carcinoma cell, so it is a possible candidate to be used in cancer gene therapy.	Arginine	30-33	tumor protein p53	Homo sapiens	44-47
9852072-10	1998	We propose that Arg-85 comprises a new distal subsite in RNase A---the P(-1) subsite.	Arginine	16-19	ribonuclease pancreatic	Bos taurus	57-64
9852075-8	1998	Mutational analysis establishes that conserved glutamate and arginine side chains within these motifs are essential for the RNA triphosphatase and ATPase activities of Cet1p in vitro and for Cet1p function in vivo.	Arginine	61-69	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	168-173
9852075-8	1998	Mutational analysis establishes that conserved glutamate and arginine side chains within these motifs are essential for the RNA triphosphatase and ATPase activities of Cet1p in vitro and for Cet1p function in vivo.	Arginine	61-69	polynucleotide 5'-phosphatase	Saccharomyces cerevisiae S288C	191-196
9852077-0	1998	Effects of Asp-369 and Arg-372 mutations on heme environment and function in human endothelial nitric-oxide synthase.	Arginine	23-26	nitric oxide synthase 3	Homo sapiens	83-116
9852077-1	1998	Eight polar amino acid residues in the putative substrate-binding region from Thr-360 to Val-379 in human endothelial nitric-oxide synthase (eNOS) (Thr-360, Arg-365, Cys-368, Asp-369, Arg-372, Tyr-373, Glu-377, and Asp-378) were individually mutated.	Arginine	157-160	nitric oxide synthase 3	Homo sapiens	106-139
9852077-1	1998	Eight polar amino acid residues in the putative substrate-binding region from Thr-360 to Val-379 in human endothelial nitric-oxide synthase (eNOS) (Thr-360, Arg-365, Cys-368, Asp-369, Arg-372, Tyr-373, Glu-377, and Asp-378) were individually mutated.	Arginine	184-187	nitric oxide synthase 3	Homo sapiens	106-139
9865714-5	1998	Direct stimulation of NO synthesis in tumor cells through the L-arginine/iNOS pathway represents a novel approach to exploit the radiosensitizing properties of NO.	Arginine	62-72	nitric oxide synthase 2, inducible	Mus musculus	73-77
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Arginine	253-256	insulin like growth factor binding protein 5	Homo sapiens	60-67
9883900-7	1998	In addition, a smaller fragment with Mr 2722 of the central IGFBP-5 region was purified and showed the sequence HTRISELKAEAVKKDRRKKLTQS (residues 121-143) indicating plasma proteolysis of IGFBP-5 C-terminal to amino acids Lys-120, Ser-143, Lys-144, and Arg-188.	Arginine	253-256	insulin like growth factor binding protein 5	Homo sapiens	188-195
9845532-3	1998	Sequencing analysis of patient"s vWF gene showed, at heterozygous state, a G--&gt;A transition resulting in the substitution of Asn for Asp at position 116 of the mature vWF subunit and a C--&gt;T transition, changing the codon for Arg 896 into a stop codon.	Arginine	232-235	von Willebrand factor	Homo sapiens	33-36
9820825-7	1998	The Rab4 cleavage sites corresponded to Arg-81 and Pro-87 of Rab5, and taken together with the finding that Rab5 was not cleaved at Arg-91 this analysis defines an eight-residue surface-exposed conformationally variable region lying in the centre of Switch II.	Arginine	40-43	RAB4A, member RAS oncogene family	Homo sapiens	4-8
9837881-1	1998	Nitric oxide synthases (NOS) are homodimeric enzymes that NADPH-dependently convert L-arginine to nitric oxide and L-citrulline.	Arginine	84-94	nitric oxide synthase 2	Homo sapiens	0-22
9868533-1	1998	The enzyme responsible for the synthesis of nitric oxide (NO) from L-arginine in mammalian tissues is known as nitric oxide synthase (NOS) (EC.1.14.13.39).	Arginine	67-77	nitric oxide synthase 2	Homo sapiens	111-132
9828234-13	1998	A close correlation was found between arginin in position 2218 in ISDR, the presence of IL-NS5A Ab, and the response to IFN therapy for genotype 1b, but this association did not predict a long-term response.	Arginine	38-45	interferon alpha 1	Homo sapiens	120-123
9873743-3	1998	The introduction of arginine mimetics at the P1 site led to potent and selective thrombin inhibitors.	Arginine	20-28	coagulation factor II, thrombin	Homo sapiens	81-89
9858249-1	1998	We report the identification in five patients (three families) affected with type 2B von Willebrand disease (VWD) of three heterozygous nucleotide substitutions at the codon for arginine 543, 545 and 578 of the mature von Willebrand factor (VWF) subunit resulting in a glutamine, proline and leucine substitution, respectively.	Arginine	178-186	von Willebrand factor	Homo sapiens	218-239
9858249-1	1998	We report the identification in five patients (three families) affected with type 2B von Willebrand disease (VWD) of three heterozygous nucleotide substitutions at the codon for arginine 543, 545 and 578 of the mature von Willebrand factor (VWF) subunit resulting in a glutamine, proline and leucine substitution, respectively.	Arginine	178-186	von Willebrand factor	Homo sapiens	241-244
9893012-6	1998	Similarly, preincubation in the presence of 1 mmol L-1 D-glucose and 12.5 mIU mL-1 human insulin reduced the Km for L-arginine influx by over 55%.	Arginine	116-126	insulin	Homo sapiens	89-96
9893012-7	1998	CONCLUSION: These data suggest that the modulation of placental transport of L-arginine by glucose and insulin could contribute to the fetal macrosomia observed in diabetic mothers.	Arginine	77-87	insulin	Homo sapiens	103-110
9862364-5	1998	The accumulation of cGMP and the production of TNF-alpha were inhibited by NG-monomethyl-L-arginine (L-NMMA), indicating that sCD21 activates the L-arginine pathway of NO production.	Arginine	89-99	tumor necrosis factor	Homo sapiens	47-56
9862364-6	1998	We demonstrated that sCD21 activates NO synthase (NOS) since it was found to enhance the conversion of L-arginine into L-citrulline and induce the intracellular expression of inducible NOS in CD23+ monocytes.	Arginine	103-113	nitric oxide synthase 2	Homo sapiens	37-48
9848359-0	1998	Homozygous arginine-72 in wild type p53 and risk of cervical cancer.	Arginine	11-19	tumor protein p53	Homo sapiens	36-39
10069701-11	1998	Pretreatment with L-arginine, a substrate for NOS, slightly diminished the CRH-induced ACTH response and considerably reduced the corticosterone response.	Arginine	18-28	corticotropin releasing hormone	Rattus norvegicus	75-78
10069701-12	1998	L-arginine also significantly reversed the L-NAME-evoked increase in the CRH-induced ACTH and corticosterone secretion.	Arginine	0-10	corticotropin releasing hormone	Rattus norvegicus	73-76
9894848-9	1998	Furthermore, the analysis using peptides mutated at the C-terminus showed that HLA-A*1101 molecules can bind peptides carrying another positively charged residue, Arg.	Arginine	163-166	major histocompatibility complex, class I, A	Homo sapiens	79-84
9822628-2	1998	The primary site at which the alpha5 beta1 integrin interacts with fibronectin is the RGD (Arg-Gly-Asp) amino acid sequence.	Arginine	91-94	fibronectin 1	Homo sapiens	67-78
9850741-2	1998	Nitric oxide synthase (NOS) is the enzyme that catalyzes the formation of nitric oxide (NO), a regulator of vascular permeability, from the guanidino nitrogen atom of L-arginine.	Arginine	167-177	nitric oxide synthase 2	Homo sapiens	0-21
9875639-6	1998	Tumor necrosis factor-alpha enhanced cationic amino acid transporter-2B mRNA expression and L-arginine transport, whereas cationic amino acid transporter-1 mRNA expression remained unchanged.	Arginine	92-102	tumor necrosis factor	Rattus norvegicus	0-27
9875639-8	1998	Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production.	Arginine	225-235	tumor necrosis factor	Rattus norvegicus	37-64
9875639-9	1998	CONCLUSIONS: In transformed hepatic stellate cells, tumor necrosis factor-alpha and interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible nitric oxide synthase expression are regulated in a differential cytokine-specific manner.	Arginine	167-177	tumor necrosis factor	Rattus norvegicus	52-79
10049129-4	1998	(2) The present experiments investigate the effects of L-NMMA, L-Name, and L-arginine on the nicotinic acetylcholine receptor channel (nAChR) using patch clamp techniques and a piezo-driven application system.	Arginine	75-85	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	135-140
9808586-7	1998	Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.	Arginine	62-65	von Willebrand factor	Homo sapiens	94-97
9808586-7	1998	Additionally, preincubation of HUVEC with a synthetic peptide Arg-Gly-Asp (RGD) that prevents vWf-mediated adhesion of SS RBC reduced the surface expression of VCAM-1 and NF-kB activation.	Arginine	62-65	vascular cell adhesion molecule 1	Homo sapiens	160-166
9813163-1	1998	The effects of the imidazoline compound RX871024 on arginine-induced insulin, glucagon, and somatostatin secretion in the isolated perfused rat pancreas have been investigated.	Arginine	52-60	somatostatin	Rattus norvegicus	92-104
9827724-7	1998	Undifferentiated carcinoma (FRO) cells had a nonsense point mutation at codon 72 (CGA-TGA, Arg-Stop) of p16, whereas the poorly differentiated papillary carcinoma (NPA) line harbored a point mutation at the exon 1-intron 1 boundary that altered the donor splicing site and caused an aberrantly spliced form of p16INK4a.	Arginine	91-94	cyclin dependent kinase inhibitor 2A	Homo sapiens	104-107
9813163-3	1998	RX871024, at 10 microM, did not influence basal hormone secretion but enhanced arginine-stimulated insulin and somatostatin release.	Arginine	79-87	somatostatin	Rattus norvegicus	111-123
9813163-2	1998	Arginine induced biphasic insulin, glucagon, and somatostatin release when infused for 20 min at 20 mM concentration and 3.3 mM glucose in the medium.	Arginine	0-8	somatostatin	Rattus norvegicus	49-61
9813163-6	1998	In conclusion, RX871024 exerts a complex effect on the endocrine pancreas challenged by arginine, comprising stimulation of insulin and somatostatin release and inhibition of glucagon release.	Arginine	88-96	somatostatin	Rattus norvegicus	136-148
9814991-1	1998	Activated macrophages avidly consume arginine via the action of inducible nitric oxide synthase (iNOS) and/or arginase.	Arginine	37-45	nitric oxide synthase 2, inducible	Mus musculus	64-95
9814991-1	1998	Activated macrophages avidly consume arginine via the action of inducible nitric oxide synthase (iNOS) and/or arginase.	Arginine	37-45	nitric oxide synthase 2, inducible	Mus musculus	97-101
9842921-12	1998	Additionally we describe a polymorphism in the Tapasin gene, with two alleles encoding arginine or threonine at peptide position 240.	Arginine	87-95	TAP binding protein	Homo sapiens	47-54
9824439-5	1998	We thus focused on L-Arg metabolism, which involves nitric oxide (NO) production through NO synthase (NOS).	Arginine	19-24	nitric oxide synthase 2	Homo sapiens	89-100
9824439-7	1998	The L-Arg-mediated NK cell activation was abolished by addition of NG-monomethyl-L-arginine, an inhibitor for iNOS.	Arginine	4-9	nitric oxide synthase 2	Homo sapiens	110-114
9786963-8	1998	NO release from PFs was also potentiated by L-Arg (ARG) (100 microM), forskolin (50 microM), and 8-bromo-cAMP (Br-cAMP) (1 mM) but not by 1,9-dideoxyforskolin (50 microM), a biologically inactive analog of forskolin.	Arginine	51-54	Rho guanine nucleotide exchange factor 12	Rattus norvegicus	44-49
9820497-4	1998	We now identify another B27-restricted epitope derived from EBNA 3B (residues 243-253, sequence RRARSLSAERY), which again accords well with the B*2705/B*2702 consensus motifs, having an arginine residue at position 2 and a tyrosine residue at the carboxyl terminus.	Arginine	186-194	melanocortin 2 receptor accessory protein	Homo sapiens	24-27
9835437-6	1998	A missense mutation replacing arginine at amino acid position 186 by histidine (R186H) was identified in the PHKA2 gene.	Arginine	30-38	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	109-114
9835437-7	1998	Mutations of the same arginine residue have been previously found in at least four other unrelated XLG II patients.	Arginine	22-30	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	99-102
9835437-8	1998	CONCLUSION: Arginine at position 186 of the alpha subunit seems to play an important role in the structure or the regulation of PHK.	Arginine	12-20	phosphorylase kinase regulatory subunit alpha 2	Homo sapiens	128-131
9870795-5	1998	The lesions were also inhibited by simultaneous administration of N(G)-monomethyl-L-arginine (L-NMMA), and this effect was mimicked by inducible NO synthase (iNOS) inhibitors, such as aminoguanidine or dexamethasone and significantly antagonized by coadministration of L-arginine.	Arginine	82-92	nitric oxide synthase 2	Rattus norvegicus	158-162
9825943-3	1998	This report presents clinical, neuropathological and molecular genetic data from 2 families in France with an identical p53 germline mutation in codon 248 (CGG-&gt;TGG; Arg-&gt;Trp) and a clustering of CNS tumors.	Arginine	169-172	tumor protein p53	Homo sapiens	120-123
9808485-8	1998	Stimulated lymphocytes of homozygous genotype (arginine/arginine) from control individuals produced significantly more TGF-beta1 in vitro (10037+/-745 pg/ml) compared with heterozygous (arginine/proline) individuals (6729+/-883 pg/ml; P<0.02).	Arginine	47-55	transforming growth factor beta 1	Homo sapiens	119-128
9790668-5	1998	Using a panel of 55 surface mutants of recombinant thrombin, we now show that the epitope for the IgG most likely includes Arg-101, Arg-233, and Lys-236 in exosite II.	Arginine	123-126	coagulation factor II, thrombin	Homo sapiens	51-59
9790668-5	1998	Using a panel of 55 surface mutants of recombinant thrombin, we now show that the epitope for the IgG most likely includes Arg-101, Arg-233, and Lys-236 in exosite II.	Arginine	132-135	coagulation factor II, thrombin	Homo sapiens	51-59
9790668-6	1998	The IgG affects the rate at which thrombin cleaves various peptide p-nitroanilide substrates with arginine in the P1 position, increasing the kcat for substrates with a P2 glycine residue but generally decreasing the kcat for substrates with a P2 proline.	Arginine	98-106	coagulation factor II, thrombin	Homo sapiens	34-42
9881601-6	1998	To prevent the action of bacterial endogenous proteases and/or thrombin, which cleaves the protein into two fragments at an Arg-Ala trypsin-sensitive site in positions 168-169, we have introduced a single mutation (Arg168--&gt;His), thus making the whole domain more stable and suitable for crystallization.	Arginine	124-127	coagulation factor II	Mus musculus	63-71
9817594-0	1998	Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone.	Arginine	0-8	parathyroid hormone 1 receptor	Homo sapiens	65-95
9817594-3	1998	Specifically, we have studied the region of the receptor that interacts with the midregion of PTH-(1-34), position 13, using a benzophenone-containing photoaffinity ligand, 125I-[Nle(8,18),Lys13(epsilon-pBz2),L-2-NaI23,Arg(26,2 7),Tyr34]bPTH-(1-34)NH2 (125I-K13).	Arginine	219-222	parathyroid hormone	Homo sapiens	94-97
9817594-5	1998	Furthermore, we have found arginine 186 to be of critical importance to the interaction of the hPTH1 Rc with 125I-K13: modification of Arg186 to either lysine or alanine does not modify receptor avidity or signal transduction by the receptor, but eliminates cross-linking to 125I-K13.	Arginine	27-35	parathyroid hormone	Homo sapiens	95-100
9808485-8	1998	Stimulated lymphocytes of homozygous genotype (arginine/arginine) from control individuals produced significantly more TGF-beta1 in vitro (10037+/-745 pg/ml) compared with heterozygous (arginine/proline) individuals (6729+/-883 pg/ml; P<0.02).	Arginine	56-64	transforming growth factor beta 1	Homo sapiens	119-128
9808485-8	1998	Stimulated lymphocytes of homozygous genotype (arginine/arginine) from control individuals produced significantly more TGF-beta1 in vitro (10037+/-745 pg/ml) compared with heterozygous (arginine/proline) individuals (6729+/-883 pg/ml; P<0.02).	Arginine	56-64	transforming growth factor beta 1	Homo sapiens	119-128
9808485-9	1998	In patients requiring lung transplantation for a fibrotic lung condition, there was an increase in the frequency of the high-producer TGF-beta1 allele (arginine).	Arginine	152-160	transforming growth factor beta 1	Homo sapiens	134-143
9743627-0	1998	An arginine residue (Arg101), which is conserved in many GroEL homologues, is required for interactions between the two heptameric rings.	Arginine	3-11	GroEL	Escherichia coli	57-62
9845266-1	1998	The melanocortins form a family of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common.	Arginine	147-150	proopiomelanocortin	Homo sapiens	87-117
9758645-8	1998	AT1 receptor blockade or cotreatment with L-arginine, but not cotreatment with hydralazine, prevented the L-NAME-induced increase in Ang II receptors and inflammatory changes.	Arginine	42-52	angiotensinogen	Rattus norvegicus	133-139
9748253-2	1998	It has been previously shown that besides synthesizing nitric oxide (NO), neuronal and inducible NO synthase (NOS) generates superoxide (O-2) under conditions of L-arginine depletion.	Arginine	162-172	nitric oxide synthase 2	Homo sapiens	97-108
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Arginine	57-65	tumor protein p53	Homo sapiens	25-28
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Arginine	57-65	tumor protein p53	Homo sapiens	112-115
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Arginine	183-191	tumor protein p53	Homo sapiens	25-28
9788606-2	1998	A common polymorphism of p53, encoding either proline or arginine at position 72, affects the susceptibility of p53 to E6-mediated degradation in vivo; Caucasian women homozygous for arginine 72 reportedly are about seven times more susceptible to HPV-associated carcinoma of the cervix than heterozygotes.	Arginine	183-191	tumor protein p53	Homo sapiens	112-115
9748253-13	1998	O-2 synthesis from eNOS requires Ca2+/calmodulin and is primarily regulated by BH4 rather than L-arginine.	Arginine	95-105	nitric oxide synthase 3	Homo sapiens	19-23
9743627-8	1998	Two different single rings created by homologous recombination could be converted back to double rings by changing the threonine, which naturally occurs at this position in E. coli GroEL, back to arginine.	Arginine	196-204	GroEL	Escherichia coli	181-186
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	84-89
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	111-116
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	0-3	fibronectin 1	Homo sapiens	143-154
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	4-7	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	84-89
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	4-7	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	111-116
9748233-1	1998	Arg-Arg-Glu-Thr-Ala-Trp-Ala (RRETAWA) is a novel ligand peptide for integrin alpha5 beta1, which blocks alpha5 beta1-mediated cell adhesion to fibronectin (Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J.	Arginine	4-7	fibronectin 1	Homo sapiens	143-154
9763534-2	1998	A common polymorphism of the paraoxonase gene (PON1) involving a Gln-to-Arg interchange at position 192 has been demonstrated to modulate PON activity toward paraoxon, a nonphysiological substrate; Arg192 (allele B) is associated with higher activity than Gln192 (allele A).	Arginine	72-75	paraoxonase 1	Homo sapiens	29-40
9750142-2	1998	Tsp-mediated cleavage of the Ala-Arg peptide bond separates the quencher, DABCYL, from the donor, EDANS, and results in a large increase in the fluorescent yield of EDANS (&gt;50-fold).	Arginine	33-36	aldo-keto reductase family 1 member E2	Homo sapiens	0-3
9763534-2	1998	A common polymorphism of the paraoxonase gene (PON1) involving a Gln-to-Arg interchange at position 192 has been demonstrated to modulate PON activity toward paraoxon, a nonphysiological substrate; Arg192 (allele B) is associated with higher activity than Gln192 (allele A).	Arginine	72-75	paraoxonase 1	Homo sapiens	47-51
9763534-2	1998	A common polymorphism of the paraoxonase gene (PON1) involving a Gln-to-Arg interchange at position 192 has been demonstrated to modulate PON activity toward paraoxon, a nonphysiological substrate; Arg192 (allele B) is associated with higher activity than Gln192 (allele A).	Arginine	72-75	paraoxonase 1	Homo sapiens	47-50
9792286-2	1998	Sequencing of the VWF gene region coding for the FVIII binding domain revealed the most frequent type 2N mutation: a single nucleotide change (G2811A) in exon 20, resulting in substitution of glutamine (Gln) for arginine (Arg) 91 in the mature VWF protein in one allele.	Arginine	212-220	von Willebrand factor	Homo sapiens	18-21
9764573-2	1998	NO is generated enzymatically from the terminal guanidinonitrogen of L-arginine by nitric oxide synthase (NOS).	Arginine	69-79	nitric oxide synthase 2	Homo sapiens	83-104
9746777-2	1998	Three sites on fibrinogen have been hypothesized to be critical for these interactions: the Ala-Gly-Asp-Val (AGDV) sequence at the C-terminus of the gamma chain and two Arg-Gly-Asp (RGD) sequences in the Aalpha chain.	Arginine	169-172	fibrinogen beta chain	Homo sapiens	15-25
9820592-2	1998	The two Arg-AGA codons at positions 253 and 254 of the URE2 gene coding sequence were exchanged by CGT codons accordingly.	Arginine	8-11	glutathione peroxidase	Saccharomyces cerevisiae S288C	55-59
9792286-2	1998	Sequencing of the VWF gene region coding for the FVIII binding domain revealed the most frequent type 2N mutation: a single nucleotide change (G2811A) in exon 20, resulting in substitution of glutamine (Gln) for arginine (Arg) 91 in the mature VWF protein in one allele.	Arginine	222-225	von Willebrand factor	Homo sapiens	18-21
9821814-5	1998	On the other hand, L-arginine, the substrate of NO synthase (NOS), was also increased by SKT administration.	Arginine	19-29	nitric oxide synthase 2	Homo sapiens	48-59
9810515-2	1998	NO is a highly diffusible gas, synthesized from L-arginine by the enzyme nitric oxide synthase (NOS).	Arginine	48-58	nitric oxide synthase 2	Homo sapiens	73-94
9809751-8	1998	CPX-2 is able to bind to Sepharose-Arg; this binding is blocked by 10 mM Arg.	Arginine	35-38	carboxypeptidase X 2 (M14 family)	Mus musculus	0-5
9809751-8	1998	CPX-2 is able to bind to Sepharose-Arg; this binding is blocked by 10 mM Arg.	Arginine	73-76	carboxypeptidase X 2 (M14 family)	Mus musculus	0-5
9768710-11	1998	CONCLUSIONS: Parenteral arginine produces non-stereo-specific peripheral vasodilation and improves endothelium-dependent vasodilation in patients with stable coronary artery disease by stimulation of insulin-dependent nitric oxide release or by nonenzymatic nitric oxide generation.	Arginine	24-32	insulin	Homo sapiens	200-207
9829828-1	1998	We describe two related manganese-binding polypeptides with L-arginine metabolizing enzyme activity that can be detected as distinct components (designated PsbY-A1 and PsbY-A2, previously called L-AME) in membranes containing Photosystem II (PS II) from spinach.	Arginine	60-70	photosystem II BY	Arabidopsis thaliana	156-160
9829828-1	1998	We describe two related manganese-binding polypeptides with L-arginine metabolizing enzyme activity that can be detected as distinct components (designated PsbY-A1 and PsbY-A2, previously called L-AME) in membranes containing Photosystem II (PS II) from spinach.	Arginine	60-70	photosystem II BY	Arabidopsis thaliana	168-172
9768691-0	1998	Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg--&gt;Cys at codon 120 (R120C).	Arginine	138-141	PROP paired-like homeobox 1	Homo sapiens	85-90
9768691-3	1998	We report on the follow-up of two consanguineous families (n = 12), with five subjects affected with CPHD (three males and two females) caused by the same nucleotide C to T transition, resulting in the substitution of Arg--&gt;Cys in PROP1 at codon 120.	Arginine	218-221	PROP paired-like homeobox 1	Homo sapiens	234-239
9831393-3	1998	Adding L-arginine to the refolding solution also increased the yield of refolded functional scFv.	Arginine	7-17	immunglobulin heavy chain variable region	Homo sapiens	92-96
9733769-3	1998	Three IGF-I arginine side chains were identified by NMR to participate in IGFBP-1 binding.	Arginine	12-20	insulin like growth factor 1	Homo sapiens	6-11
9829330-2	1998	Paraoxonase serum activity varies among individuals due to an Gln/Arg polymorphism with low (A phenotype) and high activity (B phenotype).	Arginine	66-69	paraoxonase 1	Homo sapiens	0-11
9751083-6	1998	L-Arginine treatment protected the liver partially from the elevation of collagen, bilirubins, and alkaline phosphatase and from glycogen depletion induced by CCl4 intoxication (P &lt; 0.05), but showed no significant effect on ALT, gamma-GTP, or lipid peroxidation.	Arginine	0-10	C-C motif chemokine ligand 4	Rattus norvegicus	159-163
9736696-1	1998	The biosynthesis of nitric oxide (NO) by the enzyme NO synthase (NOS) proceeds by the hydroxylation of L-arginine to form NG-hydroxy-L-arginine followed by the conversion of NG-hydroxy-L-arginine to L-citrulline and NO.	Arginine	103-113	nitric oxide synthase 2	Homo sapiens	52-63
9727013-2	1998	A novel Gsalpha mutation encoding the substitution of tryptophan for a nonconserved arginine within the switch 3 region (Gsalpha R258W) was identified in an AHO patient.	Arginine	84-92	GNAS complex locus	Homo sapiens	8-15
9727013-2	1998	A novel Gsalpha mutation encoding the substitution of tryptophan for a nonconserved arginine within the switch 3 region (Gsalpha R258W) was identified in an AHO patient.	Arginine	84-92	GNAS complex locus	Homo sapiens	121-128
9742979-1	1998	BACKGROUND: A polymorphism at codon 72 of the human tumour-suppressor gene, p53, results in translation to either arginine or proline.	Arginine	114-122	tumor protein p53	Homo sapiens	76-79
9742979-8	1998	INTERPRETATION: In the population studied, individuals homozygous for the arginine variant of codon 72 of the p53 gene were not at increased risk of cervical cancer.	Arginine	74-82	tumor protein p53	Homo sapiens	110-113
9735327-0	1998	Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis.	Arginine	84-92	nitric oxide synthase 2	Homo sapiens	40-61
9725818-0	1998	Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production.	Arginine	0-8	insulin	Homo sapiens	17-24
9725818-2	1998	We show here for the first time that the release of insulin induced by L-arginine or L-homoarginine is inhibited and that of glucagon stimulated in parallel with the rate of islet NO production.	Arginine	71-81	insulin	Homo sapiens	52-59
9725818-3	1998	It was found that L-homoarginine was approximately 25-30% less potent than L-arginine as an insulin secretagogue but equally potent as a glucagon secretagogue.	Arginine	75-85	insulin	Homo sapiens	92-99
9725818-6	1998	Moreover, inhibition of cNOS suppressed glucagon release, more so with L-arginine than with L-homoarginine as secretagogue, reflecting the relative rates of their NO production.	Arginine	71-81	nitric oxide synthase 3	Homo sapiens	24-28
9725818-7	1998	In K+-depolarized islets, inhibition of cNOS enhanced the insulin response to L-arginine by 50% and that to L-homoarginine by 23%, largely corresponding to their relative NO production.	Arginine	78-88	nitric oxide synthase 3	Homo sapiens	40-44
9725818-7	1998	In K+-depolarized islets, inhibition of cNOS enhanced the insulin response to L-arginine by 50% and that to L-homoarginine by 23%, largely corresponding to their relative NO production.	Arginine	78-88	insulin	Homo sapiens	58-65
9818055-4	1998	DNA analysis showed that patients were heterozygous for a mutation in the fibrinogen A alpha chain gene with a guanine to thymine transversion at the second base of codon 554, predicting a leucine for arginine substitution.	Arginine	201-209	fibrinogen beta chain	Homo sapiens	74-84
9699465-4	1998	Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH.	Arginine	164-167	proopiomelanocortin	Homo sapiens	215-224
11245004-1	1998	OBJECTIVE: To establish a tetracycline-regulated expression model and to determine and verify whether a specific point mutant type p53 minigene, containing an Arg--&gt;Leu substitution at amino acid 172, possesses a suppressing effect on human lung cancer.	Arginine	159-162	tumor protein p53	Homo sapiens	131-134
9730901-3	1998	In contrast, the PIR-A protein has a charged Arg residue in its transmembrane region and a short cytoplasmic domain that lacks ITIM sequences.	Arginine	45-48	pirin	Homo sapiens	17-20
9724311-6	1998	Coinfusion of L-arginine (0.33 mg/min) markedly improved the bradykinin-induced venodilation in smokers (52 +/- 7 to 90 +/- 9%; P &lt; 0.01).	Arginine	14-24	kininogen 1	Homo sapiens	61-71
9699465-4	1998	Additional energy calculations for designed cyclic analogues were used for further refinement of the model for the biologically active conformations of the His-Phe-Arg-Trp "message" sequence within the sequences of alpha-MSH and [D-Phe7]alpha-MSH.	Arginine	164-167	proopiomelanocortin	Homo sapiens	237-246
9733769-4	1998	All IGF-I arginine residues were replaced by alanines, using site-directed mutagenesis, in four single substituted variants, IGF-I(R21A), IGF-I(R50A), IGF-I(R55A), and IGF-I(R56A), and one double replacement mutant, IGF-I(R36A/R37A).	Arginine	10-18	insulin like growth factor 1	Homo sapiens	4-9
19649818-3	1998	Of the three known isozymes responsible for catalyzing the production of NO from L-arginine (L-Arg), it is the inducible form of nitric oxide synthase (iNOS) that we wish to examine here due to its involvement in a collection of diseases, including septic- and cytokine-induced shock, immune-type diabetes, rheumatoid arthritis, tissue damage, inflammation, and inflammatory bowel disease.	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	152-156
9861481-12	1998	In codon 273, CGT for arginine was mutated to AGT for serine by a C to A transversion of the first letter.	Arginine	22-30	angiotensinogen	Homo sapiens	46-49
9738648-1	1998	BACKGROUND: Nitric oxide, synthesized from L-arginine by nitric oxide synthase (NOS), is a vasodilator and inhibits vascular smooth muscle cell (SMC) proliferation and migration.	Arginine	43-53	nitric oxide synthase 2	Sus scrofa	57-78
19649818-3	1998	Of the three known isozymes responsible for catalyzing the production of NO from L-arginine (L-Arg), it is the inducible form of nitric oxide synthase (iNOS) that we wish to examine here due to its involvement in a collection of diseases, including septic- and cytokine-induced shock, immune-type diabetes, rheumatoid arthritis, tissue damage, inflammation, and inflammatory bowel disease.	Arginine	93-98	nitric oxide synthase 2	Homo sapiens	152-156
19649818-5	1998	Within these extremes lies the most conventional tactic, prohibiting NO production from iNOS with L-arginine competitive antagonists or irreversible enzyme inhibitors.	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	88-92
9801991-12	1998	In GHD, but not in normal subjects, IGF-I levels were positively associated to peak GH responses to GHRH + ARG (r = 0.57, p &lt; 0.00001); on the other hand, the GH peak after ITT was not associated to IGF-I in GHD.	Arginine	107-110	insulin like growth factor 1	Homo sapiens	36-41
9829213-8	1998	Sequencing of the Pit-1 gene revealed a heterozygous C to T transition in codon 271 resulting in substitution of tryptophane for a highly conserved arginine.	Arginine	148-156	POU class 1 homeobox 1	Homo sapiens	18-23
9739038-1	1998	BACKGROUND: A combination of epidermal growth factor (EGF) and human growth hormone (hGH) after massive enterectomy induces a 400% increase in arginine transport in the remnant distal small intestine.	Arginine	143-151	growth hormone 1	Homo sapiens	69-83
9785759-3	1998	Only one of the three can be triggered by acetylcholine (ACh) and in this vascular bed it is only this path that is dependent upon endothelial nitric oxide synthase (NOS) which produces nitric oxide (NO) from arginine.	Arginine	209-217	nitric oxide synthase 2	Homo sapiens	143-164
9699501-2	1998	BSP possesses an integrin-binding RGD (Arg-Gly-Asp) domain, which may promote interactions between HBC cells and bone extracellular matrix.	Arginine	39-42	integrin binding sialoprotein	Homo sapiens	0-3
9819805-1	1998	Nitric oxide (NO) is a free radical gas that is synthesized from L-arginine (L-Arg) by NO synthase (NOS).	Arginine	65-75	nitric oxide synthase 2	Homo sapiens	87-98
9819805-1	1998	Nitric oxide (NO) is a free radical gas that is synthesized from L-arginine (L-Arg) by NO synthase (NOS).	Arginine	77-82	nitric oxide synthase 2	Homo sapiens	87-98
9731211-1	1998	Nitric oxide (NO) synthesis is well-known to result from the oxidation of L-arginine by a family of NO synthases (NOS).	Arginine	74-84	nitric oxide synthase 2	Homo sapiens	100-112
9743071-8	1998	An insignificant threshold shift of 9 dB was observed when L-arginine was coperfused with MTC.	Arginine	59-69	metallothionein 1A	Homo sapiens	90-93
9743084-2	1998	L-Arginine increased ciliary beat frequency in vitro with a maximum response of 27.1% +/- 6.4% at 10(-3) mol/L, and this effect was reversibly blocked by pretreatment with the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine, whereas D-arginine had no such effect.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	176-187
9724716-7	1998	To disrupt the RI-RNase A interaction, three RNase A residues (Asp-38, Gly-88, and Ala-109) that form multiple contacts with RI were replaced with arginine.	Arginine	147-155	ribonuclease pancreatic	Bos taurus	18-25
10375810-0	1998	Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats.	Arginine	35-45	arginine vasopressin	Rattus norvegicus	54-65
10375810-1	1998	AIM: To study the possible role of cGMP in the effect of L-arginine-induced arginine-vasopressin (AVP) release.	Arginine	57-67	arginine vasopressin	Rattus norvegicus	85-96
10375810-1	1998	AIM: To study the possible role of cGMP in the effect of L-arginine-induced arginine-vasopressin (AVP) release.	Arginine	57-67	arginine vasopressin	Rattus norvegicus	98-101
10375810-3	1998	RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P &lt; 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level.	Arginine	39-49	arginine vasopressin	Rattus norvegicus	77-80
10375810-3	1998	RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P &lt; 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level.	Arginine	39-49	arginine vasopressin	Rattus norvegicus	313-316
10375810-4	1998	CONCLUSION: cGMP was a mediator of the effect of L-arginine-induced AVP release.	Arginine	49-59	arginine vasopressin	Rattus norvegicus	68-71
9738863-6	1998	This arginine residue is evolutionarily conserved in human, mouse, and Bacillus subtilis, indicating the importance of this residue in PPO function.	Arginine	5-13	protoporphyrinogen oxidase	Homo sapiens	135-138
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	25-33	insulin like growth factor 1	Homo sapiens	73-78
9683440-5	1998	The NO synthase inhibitor NG-monomethyl-L-arginine exaggerated the gut I/R-induced increases in both rolling leukocytes and P-selectin expression (in liver and intestine), responses that were not detected with coadministration of L-arginine or in P-selectin-deficient mice.	Arginine	40-50	selectin, platelet	Mus musculus	124-134
9683440-5	1998	The NO synthase inhibitor NG-monomethyl-L-arginine exaggerated the gut I/R-induced increases in both rolling leukocytes and P-selectin expression (in liver and intestine), responses that were not detected with coadministration of L-arginine or in P-selectin-deficient mice.	Arginine	40-50	selectin, platelet	Mus musculus	247-257
9763307-7	1998	The mutation consisted of a previously unreported C-to-T transition in exon 5 of the PPO gene, resulting in the substitution of arginine by cysteine, designated R152C.	Arginine	128-136	protoporphyrinogen oxidase	Homo sapiens	85-88
9763307-8	1998	This arginine residue is evolutionarily highly conserved in humans, mice, bacteria, yeast, and plants, indicating the importance of this residue in PPO.	Arginine	5-13	protoporphyrinogen oxidase	Homo sapiens	148-151
9701468-0	1998	Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells.	Arginine	0-8	insulin like growth factor 1	Homo sapiens	19-47
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	25-33	growth hormone 1	Homo sapiens	49-63
9707432-2	1998	BMP-4 is synthesized as an inactive precursor that is proteolytically activated by cleavage following the amino acid motif -Arg-Ser-Lys-Arg-.	Arginine	124-127	bone morphogenetic protein 4 L homeolog	Xenopus laevis	0-5
9707432-2	1998	BMP-4 is synthesized as an inactive precursor that is proteolytically activated by cleavage following the amino acid motif -Arg-Ser-Lys-Arg-.	Arginine	136-139	bone morphogenetic protein 4 L homeolog	Xenopus laevis	0-5
9707432-4	1998	The proprotein convertases (PCs) are a family of seven structurally related serine endoproteases, at least one of which, furin, cleaves after the amino acid motif -Arg-X-Arg/Lys-Arg-.	Arginine	164-167	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	121-126
9707432-4	1998	The proprotein convertases (PCs) are a family of seven structurally related serine endoproteases, at least one of which, furin, cleaves after the amino acid motif -Arg-X-Arg/Lys-Arg-.	Arginine	170-173	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	121-126
9707432-4	1998	The proprotein convertases (PCs) are a family of seven structurally related serine endoproteases, at least one of which, furin, cleaves after the amino acid motif -Arg-X-Arg/Lys-Arg-.	Arginine	170-173	furin, paired basic amino acid cleaving enzyme L homeolog	Xenopus laevis	121-126
9694882-5	1998	An Arg to Glu mutation within the FLVRQS motif in the SH2 domain of SH2-Bbeta inhibited GST-SH2-Bbeta binding to tyrosyl-phosphorylated PDGFR.	Arginine	3-6	sperm hammerhead 2	Mus musculus	54-57
9694882-5	1998	An Arg to Glu mutation within the FLVRQS motif in the SH2 domain of SH2-Bbeta inhibited GST-SH2-Bbeta binding to tyrosyl-phosphorylated PDGFR.	Arginine	3-6	SH2B adaptor protein 1	Mus musculus	68-77
9694882-5	1998	An Arg to Glu mutation within the FLVRQS motif in the SH2 domain of SH2-Bbeta inhibited GST-SH2-Bbeta binding to tyrosyl-phosphorylated PDGFR.	Arginine	3-6	SH2B adaptor protein 1	Mus musculus	92-101
9689061-7	1998	However, the concomitant addition of L-arginine and tetrahydrobiopterin (BH4) abolishes superoxide generation by eNOS.	Arginine	37-47	nitric oxide synthase 3	Homo sapiens	113-117
9712341-2	1998	PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine (A genotype) and arginine (B genotype) at position 192 and the other leucine (L genotype) and methionine (M genotype) at position 55.	Arginine	113-121	paraoxonase 1	Homo sapiens	0-4
9782366-4	1998	Kinetics of endothelial constitutive NO synthase (ecNOS) and inducible NO synthase (iNOS) activity, measured by [3H]L-arginine to [3H]L-citrulline conversion, and protein expression of ecNOS and iNOS, assessed by Western blot analysis, were unaffected by chronic NA treatment.	Arginine	116-126	nitric oxide synthase 2	Homo sapiens	61-82
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	25-33	growth hormone 1	Homo sapiens	65-67
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	35-38	growth hormone 1	Homo sapiens	49-63
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	35-38	growth hormone 1	Homo sapiens	65-67
9701468-3	1998	Pharmacological doses of arginine (Arg) increase growth hormone (GH) and IGF-I serum levels.	Arginine	35-38	insulin like growth factor 1	Homo sapiens	73-78
9701468-4	1998	Whether amino acids, particularly Arg, can directly modulate the production of IGF-I by osteoblasts is not known.	Arginine	34-37	insulin like growth factor 1	Homo sapiens	79-84
9701468-6	1998	The addition of Arg (7.5-7500 micromol/L, equivalent to 0.1- to 100-fold human plasma concentration) for 48 h increased IGF-I production (adjusted for cell number) in a concentration-dependent manner with a maximum of 2.3 +/- 0.3-fold at 7500 micromol/L Arg [x +/- standard error of the mean (SEM), n = 3 experiments, p &lt; 0.01].	Arginine	16-19	insulin like growth factor 1	Homo sapiens	120-125
9701468-7	1998	Arg (7.5-7500 micromol/L) increased the percentage of de novo collagen synthesis in a concentration-dependent manner (2.1 +/- 0.4-fold with 7500 micromol/L Arg, p &lt; 0.001) and ALP activity with a maximal stimulation of 144% +/- 13% plateauing at 750 micromol/l Arg (p = 0.002).	Arginine	0-3	alkaline phosphatase, placental	Homo sapiens	179-182
9701468-8	1998	The steady state level of IGF-I messenger ribonucleic acid (mRNA) and alpha1(I) collagen mRNA (both normalized to cyclophilin mRNA) of cells incubated with Arg at high (100-fold) or low (0.1-fold) human plasma concentrations, was 1.4 +/- 0.2, 1.2 +/- 0.2, and 1.1 +/- 0.2 after 24 h for the 7.5, 1.8, and 0.9 kb IGF-I mRNA transcripts, respectively (n = 3 experiments) and 1.5 +/- 0.2 and 3.1 +/- 0.7 after 24 and 48 h, respectively, for the combined analysis of the 5.6 and 4.7 kb alpha1(I) collagen mRNA transcripts (n = 3 experiments).	Arginine	156-159	insulin like growth factor 1	Homo sapiens	26-31
9701468-11	1998	In conclusion, Arg stimulated IGF-I production and collagen synthesis in osteoblast-like cells.	Arginine	15-18	insulin like growth factor 1	Homo sapiens	30-35
9701468-12	1998	Thus, Arg may influence bone formation by enhancing local IGF-I production.	Arginine	6-9	insulin like growth factor 1	Homo sapiens	58-63
14987560-2	1998	In humans, apoE has three major protein isoforms: E2 (cys(112), cys(158)); E3 (cys(112), arg(158)); and E4 (arg(112), arg(158)) that are encoded for by a single gene on chromosome 19.	Arginine	89-92	apolipoprotein E	Homo sapiens	11-15
9724167-1	1998	This study was aimed at an assessment of the role of oxygen-derived free radicals in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat, by measuring the levels of malonyl dialdehyde (MDA), glutathione peroxidase (GPx), catalase, and superoxide dismutase (Mn- and Cu,Zn-SOD) in the pancreatic tissue, and evaluating the protective effect of the xanthine oxidase inhibitor allopurinol.	Arginine	117-120	catalase	Rattus norvegicus	240-248
9724167-1	1998	This study was aimed at an assessment of the role of oxygen-derived free radicals in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat, by measuring the levels of malonyl dialdehyde (MDA), glutathione peroxidase (GPx), catalase, and superoxide dismutase (Mn- and Cu,Zn-SOD) in the pancreatic tissue, and evaluating the protective effect of the xanthine oxidase inhibitor allopurinol.	Arginine	117-120	superoxide dismutase 1	Rattus norvegicus	284-293
9724167-8	1998	The catalase and Mn-SOD activities were significantly decreased throughout the study, while the GPx activity was significantly reduced at 6 and 12 hr, and the Cu,Zn-SOD activity was significantly lower at 12 hr after the Arg injection as compared with the controls.	Arginine	221-224	superoxide dismutase 1	Rattus norvegicus	159-168
9777415-9	1998	We stabilized the zymogen form of human C1r by mutating the Arg(463)-Ile(464) bond.	Arginine	60-63	complement C1r	Homo sapiens	40-43
9681446-0	1998	Membrane transport of neuronal nitric oxide synthase substrate L-arginine is constitutively expressed with CAT1 and 4F2hc, but not CAT2 or rBAT.	Arginine	63-73	GIT ArfGAP 1	Rattus norvegicus	107-111
9681446-0	1998	Membrane transport of neuronal nitric oxide synthase substrate L-arginine is constitutively expressed with CAT1 and 4F2hc, but not CAT2 or rBAT.	Arginine	63-73	solute carrier family 3 member 2	Rattus norvegicus	116-121
9681446-6	1998	The data are consistent with L-arginine membrane uptake occurring via only system y+ encoded by constitutive CAT1, with possible physiologic contribution by constitutive 4F2hc transcripts in primary neuronal cultures.	Arginine	29-39	GIT ArfGAP 1	Rattus norvegicus	109-113
9694932-6	1998	administration of L-arginine (72 micromol/kg/day) significantly enhanced eosinophilic airway inflammation and goblet cell proliferation that were associated with intratracheal instillation of ovalbumin.	Arginine	18-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	192-201
9694932-7	1998	L-Arginine also increased protein levels of IL-5 and IL-2 in supernatants from the lung exposed to ovalbumin.	Arginine	0-10	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	99-108
9745866-2	1998	DNA analysis showed a novel missense change in arginine 394 of zinc finger 3 of the WT1 gene.	Arginine	47-55	WT1 transcription factor	Homo sapiens	84-87
11324546-6	1998	(3) When ET-1 + SIN-1 (5, 10, 50 mumol/L), the effects coincide with those of the ET-1 + L-Arg groups.	Arginine	89-94	endothelin 1	Homo sapiens	9-21
9648928-8	1998	However, mRNA levels for GTP cyclohydrolase I, a key enzyme in (6R)-tetrahydro-L-biopterin synthesis, and cationic amino acid transporter-2, involved in L-arginine transport, was enhanced in cells overexpressing PKCalpha compared with control cells.	Arginine	153-163	protein kinase C alpha	Homo sapiens	212-220
9700070-5	1998	The amino acid sequence of the VSF-1 DNA-binding basic domain has a Lys at position -10 instead of a conserved Arg found in the other bZIP factors isolated so far.	Arginine	111-114	transcription factor VSF-1	Solanum lycopersicum	31-36
9700070-6	1998	This lysine was found to be required for specific recognition of the non-palindromic binding site: a mutant VSF-1 with a Lys-to-Arg substitution at position -10 bound with higher affinity to a palindromic sequence than the wild-type protein.	Arginine	128-131	transcription factor VSF-1	Solanum lycopersicum	108-113
9706164-11	1998	Moreover, the up-regulated plasma levels of IL-6 were also attenuated by L-arginine administration.	Arginine	73-83	interleukin 6	Rattus norvegicus	44-48
9706164-12	1998	CONCLUSIONS: Because the adjuvant use of L-arginine restored the depressed cardiac output and organ blood flow and decreased plasma levels of IL-6, administration of this essential amino acid should be considered as a useful adjunct to fluid resuscitation for improving cardiovascular function in trauma victims.	Arginine	41-51	interleukin 6	Rattus norvegicus	142-146
9703961-7	1998	This is the first demonstration that PC1 acting alone is able to cleave pro CCK liberating the amino terminal pro peptide and a glycine and arginine extended CCK 8 which is the immediate precursor of CCK 8 amide.	Arginine	140-148	cholecystokinin	Homo sapiens	76-79
9703961-7	1998	This is the first demonstration that PC1 acting alone is able to cleave pro CCK liberating the amino terminal pro peptide and a glycine and arginine extended CCK 8 which is the immediate precursor of CCK 8 amide.	Arginine	140-148	cholecystokinin	Homo sapiens	158-161
9703961-7	1998	This is the first demonstration that PC1 acting alone is able to cleave pro CCK liberating the amino terminal pro peptide and a glycine and arginine extended CCK 8 which is the immediate precursor of CCK 8 amide.	Arginine	140-148	cholecystokinin	Homo sapiens	158-161
14987560-2	1998	In humans, apoE has three major protein isoforms: E2 (cys(112), cys(158)); E3 (cys(112), arg(158)); and E4 (arg(112), arg(158)) that are encoded for by a single gene on chromosome 19.	Arginine	108-111	apolipoprotein E	Homo sapiens	11-15
14987560-2	1998	In humans, apoE has three major protein isoforms: E2 (cys(112), cys(158)); E3 (cys(112), arg(158)); and E4 (arg(112), arg(158)) that are encoded for by a single gene on chromosome 19.	Arginine	108-111	apolipoprotein E	Homo sapiens	11-15
9668073-2	1998	Cytokine-inducible nitric-oxide (NO) synthase (iNOS) contains an oxygenase domain that binds heme, tetrahydrobiopterin, and L-arginine, and a reductase domain that binds FAD, FMN, calmodulin, and NADPH.	Arginine	124-134	nitric oxide synthase 2	Homo sapiens	47-51
9721340-4	1998	As a result of nonenzymatic/enzymatic NO oxidation, NO2- and NO3- ions are formed: L-Arg --&gt; NO --&gt; NO2-/NO3-.	Arginine	83-88	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
10083901-4	1998	In fact, when combined with arginine or pyridostigmine, growth hormone-releasing hormone (GHRH) becomes one of the most potent and reproducible tests for distinguishing patients with severe GHD from normal subjects.	Arginine	28-36	growth hormone releasing hormone	Homo sapiens	90-94
10083901-5	1998	Owing to its tolerability and its suitability for use in the elderly, the GHRH + arginine test is the best alternative choice and is at least as sensitive as the ITT provided that appropriate cut-off limits are given.	Arginine	81-89	growth hormone releasing hormone	Homo sapiens	74-78
9688579-6	1998	The IC50 for nNOS was 18 +/- 6 microM GST-PIN with 63 nM nNOS after 30 min at 37 degrees C. Uncoupled NADPH oxidation was inhibited similarly, whereas cytochrome c reductase activity, the K(M) for L-arginine, and dimerization were unaffected.	Arginine	197-207	dynein light chain LC8-type 1	Homo sapiens	42-45
9690578-1	1998	BACKGROUND: Nitric oxide (NO), a reactive free radical synthesized from L-arginine by the enzyme NO synthase (NOS), may play a role in many pathophysiologic conditions, including asthma.	Arginine	72-82	nitric oxide synthase 2	Homo sapiens	97-108
9721327-1	1998	The biogenesis of nitric oxide is catalyzed by nitric oxide synthase (NOS) which forms L-citrulline and NO from L-arginine.	Arginine	112-122	nitric oxide synthase 2	Homo sapiens	47-68
9721340-4	1998	As a result of nonenzymatic/enzymatic NO oxidation, NO2- and NO3- ions are formed: L-Arg --&gt; NO --&gt; NO2-/NO3-.	Arginine	83-88	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
9721340-9	1998	Thus, the presence of the nitric oxide cycle provides the cyclic transformation as follows: L-arginine --&gt; NO --&gt; NO2-/NO3- --&gt; NO.	Arginine	92-102	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
9688293-6	1998	This arginine residue is conserved in both the erythroid and housekeeping ALAS in vertebrates as well as in all other known ALAS proteins and is located in a predicted alpha-helix region close to the amino-terminus of the enzymatic region of the protein.	Arginine	5-13	5'-aminolevulinate synthase 1	Homo sapiens	74-78
9662510-1	1998	BACKGROUND: The homodimeric nitric oxide synthase (NOS) catalyzes conversion of L-arginine to L-citrulline and nitric oxide.	Arginine	80-90	nitric oxide synthase 2	Homo sapiens	28-49
9688293-6	1998	This arginine residue is conserved in both the erythroid and housekeeping ALAS in vertebrates as well as in all other known ALAS proteins and is located in a predicted alpha-helix region close to the amino-terminus of the enzymatic region of the protein.	Arginine	5-13	5'-aminolevulinate synthase 1	Homo sapiens	124-128
9618168-9	1998	This mutation is a G-->A transition altering an arginine residue to a histidine in a highly conserved location in the second helix of the homeobox of RIEG1.	Arginine	48-56	paired like homeodomain 2	Homo sapiens	150-155
9756016-5	1998	RESULTS: Glucagon and C-peptide secretions after arginine stimulation were reduced in patients with moderate and severe chronic pancreatitis while no parameter was able to show impaired endocrine function in the early stage (ERP I) of the disease.	Arginine	49-57	insulin	Homo sapiens	22-31
9737781-3	1998	Sequencing of the PNP gene, which is located on chromosome 14ql3, of the patient led to the identification of three point mutations in exon 2 at amino acid positions 20 (His, silent mutation), 24 (Arg-->termination codon) and 51 (Ser-->Gly).	Arginine	197-200	purine nucleoside phosphorylase	Homo sapiens	18-21
9674632-0	1998	Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension.	Arginine	118-128	angiotensin I converting enzyme	Homo sapiens	0-29
9674632-8	1998	These findings suggest that angiotensin-converting enzyme inhibition improves the impaired endothelium-dependent renovascular relaxation in patients with essential hypertension due to the increase in nitric oxide production and that the reduction in blood pressure with a calcium antagonist does not play a major role in the potentiation of L-arginine/nitric oxide-mediated effects.	Arginine	341-351	angiotensin I converting enzyme	Homo sapiens	28-57
18465556-1	1998	There is considerable evidence that excessive nitric oxide (NO) synthesized from L-arginine by inducible nitric oxide synthase (iNOS) plays an important pathological role in inflammatory arthritis.	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	128-132
18465556-1	1998	There is considerable evidence that excessive nitric oxide (NO) synthesized from L-arginine by inducible nitric oxide synthase (iNOS) plays an important pathological role in inflammatory arthritis.	Arginine	81-91	nitric oxide synthase 2	Homo sapiens	95-126
9710744-3	1998	The properdin gene in the Danish family contained a point mutation in exon 8 causing a Gln316--&gt;Arg substitution, distinct from a point mutation in exon 4 previously found in the Swedish family.	Arginine	99-102	complement factor properdin	Homo sapiens	4-13
9669257-3	1998	We hypothesized that the nature of endothelial injury associated with individual cardiovascular risk factors might be different and that this might affect the response to L-arginine, the substrate for endothelial nitric oxide synthase.	Arginine	171-181	nitric oxide synthase 3	Homo sapiens	201-234
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	23-26	coagulation factor II, thrombin	Homo sapiens	0-8
9648854-4	1998	This hypothesis is supported by the finding that addition of L-arginine, which serves as a precursor and limiting factor of enzyme-derived NO production, potentiated TNF-alpha/LPS-induced loss of viability.	Arginine	61-71	tumor necrosis factor	Rattus norvegicus	166-175
9721014-1	1998	Biosynthesis of nitric oxide (NO) is performed by the dimeric, heme-containing enzyme nitric oxide synthase, which requires the flavins FAD and FMN, as well as the pteridine cofactor (6R)-5,6,7,8-tetrahydro-L-biopterin (H4biopterin) in order to catalyze the NADPH-dependent oxidation of L-arginine.	Arginine	287-297	nitric oxide synthase 2	Homo sapiens	86-107
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	32-35	coagulation factor II, thrombin	Homo sapiens	0-8
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	32-35	coagulation factor II, thrombin	Homo sapiens	0-8
9632668-6	1998	Thrombin cleavage at Arg-709 and/or Arg-1018 yielded FV molecules that were still able to function as APC cofactors, whereas cleavage at Arg-1545 led to a complete loss in APC-cofactor function.	Arginine	21-24	coagulation factor II, thrombin	Homo sapiens	0-8
9662426-4	1998	The results indicate that the MAPK/ERK and SAPK2/p38 cascades are both rate-limiting for LPS- and IFNgamma-stimulated arginine uptake, but not for iNOS synthesis.	Arginine	118-126	mitogen-activated protein kinase 1	Mus musculus	30-34
9642086-0	1998	An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.	Arginine	3-6	RNA binding motif protein 8A	Homo sapiens	62-65
9642086-5	1998	Alanine scanning of TR13 has revealed that mutations in either Lys or Arg residues result in altered TAR-binding, and molecular modelling/docking experiments have shown that the two Arg residues of TR13 can interact with two appropriately spaced guanine residues in the upper-stem/loop of TAR.	Arginine	70-73	RNA binding motif protein 8A	Homo sapiens	101-104
9642086-5	1998	Alanine scanning of TR13 has revealed that mutations in either Lys or Arg residues result in altered TAR-binding, and molecular modelling/docking experiments have shown that the two Arg residues of TR13 can interact with two appropriately spaced guanine residues in the upper-stem/loop of TAR.	Arginine	182-185	RNA binding motif protein 8A	Homo sapiens	101-104
9642086-5	1998	Alanine scanning of TR13 has revealed that mutations in either Lys or Arg residues result in altered TAR-binding, and molecular modelling/docking experiments have shown that the two Arg residues of TR13 can interact with two appropriately spaced guanine residues in the upper-stem/loop of TAR.	Arginine	182-185	RNA binding motif protein 8A	Homo sapiens	289-292
9642058-5	1998	The known stereochemistry of the arginine binding pocket was used for the rational design of a mutant ArgR with altered ligand specificity.	Arginine	33-41	arginine repressor	Escherichia coli	102-106
9642058-1	1998	Arginine biosynthesis in Escherichia coli is negatively regulated by the hexameric repressor protein ArgR and the corepressor L-arginine.	Arginine	0-8	arginine repressor	Escherichia coli	101-105
9642058-2	1998	L-Arginine binds to ArgR in the C-terminal domain of the repressor.	Arginine	0-10	arginine repressor	Escherichia coli	20-24
9662426-1	1998	Bacterial lipopolysaccharide (LPS) in the presence of interferon gamma (IFNgamma) stimulates the synthesis of the cationic amino acid transporter 2B (CAT-2B) and inducible nitric oxide synthetase (iNOS) in RAW264 macrophages, which are thought to underlie the increased rate of arginine uptake into these cells and its conversion to nitric oxide, respectively.	Arginine	278-286	interferon gamma	Mus musculus	54-81
9662426-1	1998	Bacterial lipopolysaccharide (LPS) in the presence of interferon gamma (IFNgamma) stimulates the synthesis of the cationic amino acid transporter 2B (CAT-2B) and inducible nitric oxide synthetase (iNOS) in RAW264 macrophages, which are thought to underlie the increased rate of arginine uptake into these cells and its conversion to nitric oxide, respectively.	Arginine	278-286	nitric oxide synthase 2, inducible	Mus musculus	162-195
9662426-4	1998	The results indicate that the MAPK/ERK and SAPK2/p38 cascades are both rate-limiting for LPS- and IFNgamma-stimulated arginine uptake, but not for iNOS synthesis.	Arginine	118-126	mitogen-activated protein kinase 1	Mus musculus	35-38
9662426-2	1998	Here I demonstrate that the LPS- and IFNgamma-induced increase in arginine uptake into RAW264 cells is partially suppressed in the presence of PD 98059, partially suppressed in the presence of SB 203580, and completely inhibited by both drugs.	Arginine	66-74	interferon gamma	Mus musculus	37-45
9662426-4	1998	The results indicate that the MAPK/ERK and SAPK2/p38 cascades are both rate-limiting for LPS- and IFNgamma-stimulated arginine uptake, but not for iNOS synthesis.	Arginine	118-126	mitogen-activated protein kinase 11	Mus musculus	43-48
9662426-4	1998	The results indicate that the MAPK/ERK and SAPK2/p38 cascades are both rate-limiting for LPS- and IFNgamma-stimulated arginine uptake, but not for iNOS synthesis.	Arginine	118-126	interferon gamma	Mus musculus	98-106
9767830-4	1998	NO SYNTHESIS: Nitric oxide is synthesized from L-arginine by NO-synthetase whose activity is regulated by intracellular calcium concentration and modulated by pharmacological compounds such as acetylcholine, 5-hydroxytryptamine, bradykinin and ADP as well as the sheer forces produced by blood flow.	Arginine	47-57	kininogen 1	Homo sapiens	229-239
9614060-10	1998	These results suggest that Cat3 compensates for the loss of functional Cat1 in cells derived from Cat1 knockout mice and mediates the majority of high affinity arginine transport.	Arginine	160-168	dominant cataract 3	Mus musculus	27-31
9690920-2	1998	Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192).	Arginine	80-83	paraoxonase 1	Homo sapiens	64-69
9652798-1	1998	The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC.	Arginine	203-211	tumor protein p53	Homo sapiens	155-158
9652798-1	1998	The prognostic value of the mutation of the p53 tumor suppressor gene in non-small cell lung carcinomas (NSCLC) is controversial and a polymorphism of the p53 gene at codon 72 consisting of two alleles, arginine (Arg) and proline (Pro), has been reported to be associated with the incidence of smoking-related NSCLC.	Arginine	213-216	tumor protein p53	Homo sapiens	155-158
9630497-0	1998	Role of the gamma chain Ala-Gly-Asp-Val and Aalpha chain Arg-Gly-Asp-Ser sites of fibrinogen in coaggregation of platelets and fibrinogen-coated beads.	Arginine	57-60	fibrinogen beta chain	Homo sapiens	82-92
9657386-10	1998	The mechanism of PKC activation by Arg-rich substrates, therefore, does not involve their ability to bind to the active site.	Arginine	35-38	protein kinase C alpha	Homo sapiens	17-20
9797678-0	1998	Ocular signs associated with a rhodopsin mutation (Cys-167--&gt;Arg) in a family with autosomal dominant retinitis pigmentosa.	Arginine	64-67	rhodopsin	Homo sapiens	31-40
9690866-2	1998	The role of the L-arginine-nitric oxide (NO) pathway on the formation of prostaglandin E2 (PGE2) by human cultured astroglial cells incubated with interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) was investigated.	Arginine	16-26	interleukin 1 beta	Homo sapiens	147-164
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Arginine	177-187	interleukin 1 beta	Homo sapiens	98-106
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Arginine	177-187	tumor necrosis factor	Homo sapiens	111-120
9690866-14	1998	The present experiments demonstrated that the release of PGE2 by astroglial cells pretreated with IL-1beta and TNF-alpha is due to enhanced COX-2 activity via activation of the L-arginine-NO pathway, and this may be relevant to the understanding of the pathophysiological mechanisms underlying neuroimmune disorders.	Arginine	177-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	140-145
9746266-3	1998	PON1 exhibits two sequence polymorphisms, Arg--&gt;Gln 192 and Met--&gt;Leu 55, respectively, of which the former is responsible for the distinct catalytic activity of the two corresponding allozymes against paraoxon.	Arginine	42-45	paraoxonase 1	Homo sapiens	0-4
9690052-9	1998	Arginine stimulated (p &lt; 0.001) insulin secretion dose-dependently (SI: 2.2 +/- 0.3 with 5 mmol/l and 2.9 +/- 0.2 with 10 mmol/l).	Arginine	0-8	insulin	Homo sapiens	35-42
9741827-7	1998	In PMHP and NFA, met-enkephalin-Arg-Phe immunoreactivity was detected in intermediate- and low-mol-wt materials, and it was absent in GH-PA.	Arginine	32-35	proopiomelanocortin	Homo sapiens	17-31
9741827-8	1998	Immunoblotting of ACTH-PA showed that met-enkephalin-Arg-Phe immunoreactivity corresponded to peptides of 44, 32-30, 27, and 17 kDa.	Arginine	53-56	proopiomelanocortin	Homo sapiens	38-52
9643364-2	1998	We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405, Arg 407, Lys 409, Lys 415, and Lys 416) of avian LPL with asparagine.	Arginine	132-135	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	190-193
9607842-4	1998	The effects of C3a and C3a(des)Arg on IL-6 gene expression and protein production in human peripheral blood mononuclear cells (PBMC) were investigated.	Arginine	31-34	interleukin 6	Homo sapiens	38-42
9607842-6	1998	However, C3a and C3a(des)Arg affected endotoxin-induced IL-6 synthesis in a dose-dependent manner.	Arginine	25-28	interleukin 6	Homo sapiens	56-60
9607842-7	1998	In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels.	Arginine	91-94	interleukin 6	Homo sapiens	104-108
9607842-8	1998	These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes.	Arginine	43-46	interleukin 6	Homo sapiens	117-121
9607842-8	1998	These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes.	Arginine	43-46	interleukin 6	Homo sapiens	200-204
9605134-1	1998	Activated murine macrophages metabolize L-arginine via two main pathways that are catalyzed by the inducible enzymes nitric oxide synthase (iNOS) and arginase.	Arginine	40-50	nitric oxide synthase 2, inducible	Mus musculus	140-144
9643364-7	1998	Mutation of previously identified heparin-binding regions of LPL results in a relatively small decrease in heparin-binding affinity, as compared with mutations in this carboxyl-terminal region, indicating that Lys 321, Arg 405, Arg 407, Lys 409, and Lys 416 constitute the major heparin-binding domain in LPL.	Arginine	219-222	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	61-64
9643364-7	1998	Mutation of previously identified heparin-binding regions of LPL results in a relatively small decrease in heparin-binding affinity, as compared with mutations in this carboxyl-terminal region, indicating that Lys 321, Arg 405, Arg 407, Lys 409, and Lys 416 constitute the major heparin-binding domain in LPL.	Arginine	228-231	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	61-64
9607760-2	1998	A common polymorphism that occurs in the p53 amino-acid sequence results in the presence of either a proline or an arginine at position 72.	Arginine	115-123	tumor protein p53	Homo sapiens	41-44
10434255-3	1998	Among these new antagonists, the guanidinium cations, which appear not only in the terminal arginine residues of BK but also in several nonpeptidic antagonists, will be substituted by groups with characteristics similar in terms of electrostatic potential, electron density, shape, etc.	Arginine	92-100	kininogen 1	Homo sapiens	113-115
9630653-9	1998	The helical region in hEGFRp commences four residues later than predicted via hydrophobicity profiles, and extends to include several charged arginine residues which would lie on the cytosolic side of the membrane.	Arginine	142-150	epidermal growth factor receptor	Homo sapiens	22-28
9582298-3	1998	This has allowed the identification of the sequence Leu-Ile-Arg-Trp (LIRW) as necessary for the access of MAL to GEMs.	Arginine	60-63	mal, T cell differentiation protein	Homo sapiens	106-109
9607760-3	1998	The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form.	Arginine	118-126	tumor protein p53	Homo sapiens	57-60
9607760-3	1998	The effect of this polymorphism on the susceptibility of p53 to E6-mediated degradation has been investigated and the arginine form of p53 was found to be significantly more susceptible than the proline form.	Arginine	118-126	tumor protein p53	Homo sapiens	135-138
9607760-4	1998	Moreover, allelic analysis of patients with HPV-associated tumours revealed a striking overrepresentation of homozygous arginine-72 p53 compared with the normal population, which indicated that individuals homozygous for arginine 72 are about seven times more susceptible to HPV-associated tumorigenesis than heterozygotes.	Arginine	120-128	tumor protein p53	Homo sapiens	132-135
9607760-4	1998	Moreover, allelic analysis of patients with HPV-associated tumours revealed a striking overrepresentation of homozygous arginine-72 p53 compared with the normal population, which indicated that individuals homozygous for arginine 72 are about seven times more susceptible to HPV-associated tumorigenesis than heterozygotes.	Arginine	221-229	tumor protein p53	Homo sapiens	132-135
9585419-1	1998	The amyloid-beta peptide (Abeta) can mediate cell attachment by binding to beta1 integrins through an arg-his-asp sequence.	Arginine	102-105	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	75-80
9709401-5	1998	The iNOS activity was estimated from conversion rates of L-arginine to L-citrulline and intracellular cGMP contents were measured with radioimmunoassay.	Arginine	57-67	nitric oxide synthase 2	Gallus gallus	4-8
9565609-9	1998	By site-directed mutagenesis the invariant lysine residue in the NTP-binding motif of CSB was substituted with a physicochemically related arginine.	Arginine	139-147	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	86-89
9572852-10	1998	On the contrary, the distal heme pocket of iNOS and nNOS seems to be closed after binding of l-Arg and BH4, particularly in the Fe(II) state.	Arginine	93-98	nitric oxide synthase 2	Rattus norvegicus	43-47
9572853-7	1998	By further proteolytic digestion after denaturation and reduction, it was also possible to degrade the PAI-1 moiety, and we isolated a fragment containing 10 amino acids from uPA, encompassing the active site Ser, and 6 amino acids from PAI-1, including the P1 Arg.	Arginine	261-264	plasminogen activator, urokinase	Homo sapiens	175-178
9630344-10	1998	The competitive nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NOARG) not only blocked L-arginine-induced relaxations, but also significantly increased spontaneous contractile activity when added alone (P &lt; 0.05); the inactive D-enantiomer of NOARG had no such effect.	Arginine	69-79	nitric oxide synthase 2	Homo sapiens	16-37
9666868-10	1998	There was a significant relationship between AUCGH and peak GH response to arginine in the patients (r = 0.89, P &lt; 0.0001) and in the controls (r = 0.56, P = 0.005).	Arginine	75-83	growth hormone 1	Homo sapiens	48-50
9666868-15	1998	There was a significant downward trend in the peak GH response to arginine with increasing severity of hypopituitarism (J = -3.04, P = 0.0012).	Arginine	66-74	growth hormone 1	Homo sapiens	51-53
9635249-2	1998	In the lung, arginine utilization is increased after the inducible form of NOS (iNOS) is expressed during inflammation.	Arginine	13-21	nitric oxide synthase 2	Rattus norvegicus	80-84
9575152-0	1998	Changing residue 338 in human factor IX from arginine to alanine causes an increase in catalytic activity.	Arginine	45-53	coagulation factor IX	Homo sapiens	30-39
9709410-7	1998	CONCLUSIONS: The L-arginine/nitric oxide pathway contributes to substance P-induced t-PA release in vivo in man.	Arginine	17-27	tachykinin precursor 1	Homo sapiens	64-75
9589665-8	1998	The peak GH response to GHRH + ARG, but not that to ITT, was positively (though weakly) associated with insulin-like growth factor-I levels (r = 0.35, P &lt; 0.03).	Arginine	31-34	growth hormone 1	Homo sapiens	9-11
9589665-8	1998	The peak GH response to GHRH + ARG, but not that to ITT, was positively (though weakly) associated with insulin-like growth factor-I levels (r = 0.35, P &lt; 0.03).	Arginine	31-34	insulin like growth factor 1	Homo sapiens	104-132
9589665-3	1998	GHRH + arginine (GHRH + ARG) is one of the most promising tests in alternative to ITT.	Arginine	7-15	growth hormone releasing hormone	Homo sapiens	17-21
9589665-3	1998	GHRH + arginine (GHRH + ARG) is one of the most promising tests in alternative to ITT.	Arginine	24-27	growth hormone releasing hormone	Homo sapiens	0-4
9573545-4	1998	Compared to the control infusion, L-arginine did not significantly alter blood pressure, inulin or paraaminohippurate clearance, but significantly increased (P &lt; 0.05) the excretion of NO2 + NO3 (NOx) (LS, 157 +/- 46 to 210 +/- 48 mumol.min-1; HS, 138 +/- 30 to 182 +/- 70) and cGMP (LS, 253 +/- 63 to 337 +/- 76 pmol.min-1; HS, 311 +/- 68 to 563 +/- 52).	Arginine	34-44	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
9574512-4	1998	Association of pp16 with Ly-49D involves a transmembrane arginine since mutation to leucine (Ly-49D[R54L]) abolishes association with pp16 in transfected P815 cells.	Arginine	57-65	killer cell lectin-like receptor, subfamily A, member 4	Mus musculus	25-31
9580623-4	1998	Trypsin-catalyzed cleavage of Boc-Ile-Glu-Arg-methylcoumarinamide, a substrate unrelated in sequence to VIP, proceeded at equivalent rates in the absence and presence of PG, which suggests that the phospholipid did not exert a nonspecific inhibitory effect on the enzyme.	Arginine	42-45	vasoactive intestinal polypeptide	Mus musculus	104-107
9573545-7	1998	L-arginine increased plasma insulin concentration significantly (P &lt; 0.05).	Arginine	0-10	insulin	Homo sapiens	28-35
9573545-10	1998	In conclusion, L-arginine increases the excretion of NOx and cGMP and increases plasma insulin, but the effect on sodium excretion depends upon salt intake.	Arginine	15-25	insulin	Homo sapiens	87-94
9548753-3	1998	We have previously shown that the carboxylate-state structure of KR-ET-1 is more constrained and stabilized by a salt bridge between Arg(-1) and the Asp8 or Glu10 side chain [Aumelas et al.	Arginine	133-136	endothelin 1	Homo sapiens	68-72
9591749-10	1998	Peak insulin levels 1 minute after the arginine bolus were lower in rats infused with glucosamine versus saline (274.00+/-30.38 v 176.25+/-20.12 microU x ml(-1), P=.0319).	Arginine	39-47	insulin	Homo sapiens	5-12
9545275-0	1998	The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin.	Arginine	32-40	neurofibromin 1	Homo sapiens	102-115
9545275-2	1998	Comparison of the primary sequences of RasGAPs shows two invariant arginine residues (Arg1276 and Arg1391 of neurofibromin).	Arginine	67-75	neurofibromin 1	Homo sapiens	109-122
9599009-4	1998	These patterns were further extended to other members in each subfamily and the geometry orientation of crucial arginines R789 in p120 and R282 in p50 and of important stabilizing residues like p120R903 and p50N391 was confirmed.	Arginine	112-121	Rho guanine nucleotide exchange factor 7	Homo sapiens	147-150
9556561-1	1998	The nucleolar proteins Gar1p and fibrillarin possess a typical nucleolar glycine/arginine-rich domain and belong to ribonucleoprotein particles.	Arginine	81-89	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	23-28
9648150-9	1998	Molecular analysis revealed a point mutation within exon 9 of the WT1 gene (394 ARG--&gt;TRP), which was homozygous in the tumor and heterozygous within renal parenchyma.	Arginine	80-83	WT1 transcription factor	Homo sapiens	66-69
9667070-5	1998	Macro-ARG revealed that the amount of both Ang II and AT1 receptors in the renal medulla greatly exceeded those in the renal cortex.	Arginine	6-9	angiotensinogen	Rattus norvegicus	43-49
9554877-6	1998	In some cases, the arginine may even interact with pi-clouds of phenyl residues of CysLT1 antagonists.	Arginine	19-27	cysteinyl leukotriene receptor 1	Homo sapiens	83-89
9646269-6	1998	The molecular study evidenced an homozygous point mutation (Arg--&gt;Cys) at position 77 of exon 3 of the gene coding for the 50 kD subunit of the alpha-sarcoglycan complex localised in chromosome 17.	Arginine	60-63	sarcoglycan alpha	Homo sapiens	147-164
9537584-4	1998	We used here the mutated IGF-I-R with a lysine to arginine residue 1003 substitution, called IGF-I-KR, which carries a mutation in the ATP-binding domain of the intracellular beta subunit, while the extracellular, ligand binding alpha subunit remains unchanged.	Arginine	50-58	insulin like growth factor 1	Homo sapiens	25-30
9537584-4	1998	We used here the mutated IGF-I-R with a lysine to arginine residue 1003 substitution, called IGF-I-KR, which carries a mutation in the ATP-binding domain of the intracellular beta subunit, while the extracellular, ligand binding alpha subunit remains unchanged.	Arginine	50-58	insulin like growth factor 1	Homo sapiens	93-98
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Arginine	139-142	fibronectin 1	Homo sapiens	19-30
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Arginine	139-142	fibronectin 1	Homo sapiens	169-180
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Arginine	139-142	fibronectin 1	Homo sapiens	169-180
9531562-2	1998	The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils.	Arginine	139-142	fibronectin 1	Homo sapiens	169-180
9548753-11	1998	Assuming that the formation of disulfide bonds occurs in a thermodynamically controlled step, we have hypothesized that the Arg(-1)-Asp8 salt bridge and concomitant interactions could be responsible for the increase in yield of the native isomer of KR-ET-1.	Arginine	124-127	endothelin 1	Homo sapiens	252-256
9548753-16	1998	Altogether, these results allow us to hypothesize that the salt bridge between two highly conserved residues, one belonging to the prosequence [Arg(-1)] and the other to the mature sequence [Asp8], is involved in the formation of the native disulfide isomer of ET-1.	Arginine	144-147	endothelin 1	Homo sapiens	261-265
9546285-10	1998	Only one PCNSL showed a mutation of the TP53 gene, i.e., a missense mutation at codon 248 (CGG to TGG:Arg to Trp).	Arginine	102-105	tumor protein p53	Homo sapiens	40-44
9538004-0	1998	Rhodopsin arginine-135 mutants are phosphorylated by rhodopsin kinase and bind arrestin in the absence of 11-cis-retinal.	Arginine	10-18	rhodopsin	Homo sapiens	0-9
9538004-1	1998	Arginine-135, located at the border between the third transmembrane domain and the second cytoplasmic loop of rhodopsin, is one of the most highly conserved amino acids in the family of G protein-coupled receptors.	Arginine	0-8	rhodopsin	Homo sapiens	110-119
9538004-2	1998	The effect of mutation at Arg-135 on the ability of rhodopsin to undergo desensitization was investigated.	Arginine	26-29	rhodopsin	Homo sapiens	52-61
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	54-57	parathyroid hormone	Homo sapiens	14-17
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	54-57	parathyroid hormone	Homo sapiens	189-192
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	Arginine	106-109	Rho GTPase activating protein 45	Homo sapiens	117-120
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	Arginine	106-109	Rho GTPase activating protein 45	Homo sapiens	117-120
9578472-4	1998	In the present study, attention has been focused on the relative reactivities of HNO2, peroxynitrite, and NO in the presence of dioxygen, towards the arginine and tyrosine residues of the peptide angiotensin II.	Arginine	150-158	angiotensinogen	Homo sapiens	196-210
9585399-8	1998	The post-arginine insulin levels during hyperglycaemia were increased by 45% in the Type 2 DM-risk group (p &lt; 0.02).	Arginine	9-17	insulin	Homo sapiens	18-25
9578472-9	1998	Further in vivo studies show that transformations of the arginine residue in angiotensin II do not alter its vasoconstrictive properties, whereas nitration of the tyrosine residue totally inhibits them.	Arginine	57-65	angiotensinogen	Homo sapiens	77-91
9588494-3	1998	Several cases of mutations in the Pit-1 gene have been reported; the most common one is a sporadic mutation altering an arginine (R) to a tryptophan (W) in codon 271, in one allele of the Pit-1 gene.	Arginine	120-128	POU class 1 homeobox 1	Homo sapiens	34-39
9568729-3	1998	Similarly, arginine uptake and expression of the inducible nitric oxide synthase (iNOS) gene in response to bacterial DNA in BMM occurred only after IFN-gamma priming.	Arginine	11-19	nitric oxide synthase 2	Homo sapiens	82-86
9568729-3	1998	Similarly, arginine uptake and expression of the inducible nitric oxide synthase (iNOS) gene in response to bacterial DNA in BMM occurred only after IFN-gamma priming.	Arginine	11-19	interferon gamma	Homo sapiens	149-158
11081183-11	1998	ARG strikingly potentiated the GHRH-induced GH rise (2640.8 +/- 273.6 micrograms/L/h, p &lt; 0.01) but not the HEX-induced one (2371.7 +/- 387.2 micrograms/L/h) as well as the synergistical effect of HEX and GHRH (4009.1 +/- 360.8 micrograms/L/h).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	31-35
11081183-11	1998	ARG strikingly potentiated the GHRH-induced GH rise (2640.8 +/- 273.6 micrograms/L/h, p &lt; 0.01) but not the HEX-induced one (2371.7 +/- 387.2 micrograms/L/h) as well as the synergistical effect of HEX and GHRH (4009.1 +/- 360.8 micrograms/L/h).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	208-212
9730265-12	1998	Pre-incubation of segments with dexamethasone (1 microM), to inhibit inducible NOS (iNOS), or with the antibiotic polymyxin B (10 microg ml(-1)) reduced the L-Arg inhibition, whereas it was increased by lipopolysaccharide (LPS, 100 ng ml(-1)), an inductor of iNOS.	Arginine	157-162	nitric oxide synthase 2	Rattus norvegicus	69-82
9730265-12	1998	Pre-incubation of segments with dexamethasone (1 microM), to inhibit inducible NOS (iNOS), or with the antibiotic polymyxin B (10 microg ml(-1)) reduced the L-Arg inhibition, whereas it was increased by lipopolysaccharide (LPS, 100 ng ml(-1)), an inductor of iNOS.	Arginine	157-162	nitric oxide synthase 2	Rattus norvegicus	84-88
9730265-12	1998	Pre-incubation of segments with dexamethasone (1 microM), to inhibit inducible NOS (iNOS), or with the antibiotic polymyxin B (10 microg ml(-1)) reduced the L-Arg inhibition, whereas it was increased by lipopolysaccharide (LPS, 100 ng ml(-1)), an inductor of iNOS.	Arginine	157-162	nitric oxide synthase 2	Rattus norvegicus	259-263
9730265-15	1998	The present results suggest that L-Arg inhibition of the PGF2alpha- and K+-induced contractions in rat MCA is the result of NO synthesis by iNOS stimulation.	Arginine	33-38	nitric oxide synthase 2	Rattus norvegicus	140-144
11081183-13	1998	On the other hand, in E ARG restored the GH response to GHRH (1858.9 +/- 172.8 micrograms/L/h, p &lt; 0.01) and even those to HEX (2069.5 +/- 528.7 micrograms/L/h, p &lt; 0.01) and HEX + GHRH (4406.0 +/- 1079.2 micrograms/L/h, p &lt; 0.05).	Arginine	24-27	growth hormone releasing hormone	Homo sapiens	56-60
11081183-13	1998	On the other hand, in E ARG restored the GH response to GHRH (1858.9 +/- 172.8 micrograms/L/h, p &lt; 0.01) and even those to HEX (2069.5 +/- 528.7 micrograms/L/h, p &lt; 0.01) and HEX + GHRH (4406.0 +/- 1079.2 micrograms/L/h, p &lt; 0.05).	Arginine	24-27	growth hormone releasing hormone	Homo sapiens	187-191
9588494-3	1998	Several cases of mutations in the Pit-1 gene have been reported; the most common one is a sporadic mutation altering an arginine (R) to a tryptophan (W) in codon 271, in one allele of the Pit-1 gene.	Arginine	120-128	POU class 1 homeobox 1	Homo sapiens	188-193
9521739-1	1998	Inducible nitric oxide synthase (iNOS; EC 1.14.13.39) catalyzes the NADPH-dependent oxidation of one of the free guanidino nitrogens of L-Arg to form nitric oxide and L-citrulline.	Arginine	136-141	nitric oxide synthase 2	Homo sapiens	0-31
9521739-1	1998	Inducible nitric oxide synthase (iNOS; EC 1.14.13.39) catalyzes the NADPH-dependent oxidation of one of the free guanidino nitrogens of L-Arg to form nitric oxide and L-citrulline.	Arginine	136-141	nitric oxide synthase 2	Homo sapiens	33-37
9521739-3	1998	L-Arg analogues with sequentially shorter methylene spacing between the guanidino group and the amino acid portion of the molecule were not iNOS substrates but were reversible inhibitors.	Arginine	0-5	nitric oxide synthase 2	Homo sapiens	140-144
9521691-0	1998	Lysine and arginine residues in the N-terminal 18% of apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein.	Arginine	11-19	apolipoprotein B	Homo sapiens	54-70
9501171-5	1998	Five REGalpha mutants that remain inactive in the mixing assay contain amino acid substitutions clustered between Arg-141 and Gly-149.	Arginine	114-117	proteasome activator subunit 1	Homo sapiens	5-13
9521691-11	1998	Since lysine and arginine residues in apoB are known to interact with the LDL receptors and heparin, we studied the effect of different glycosaminoglycans on apoB-MTP interactions.	Arginine	17-25	apolipoprotein B	Homo sapiens	38-42
9521691-10	1998	These studies indicated that lysine and arginine, but not aspartic and glutamic acid, residues are critical for apoB-MTP interactions, whereas histidine residues are not as critical.	Arginine	40-48	apolipoprotein B	Homo sapiens	112-116
9521691-12	1998	Glycosaminoglycans had no significant inhibitory effect on apoB-MTP interactions, suggesting that the lysine and arginine residues crucial for apoB-MTP interactions are different from those that interact with the LDL receptor and heparin.	Arginine	113-121	apolipoprotein B	Homo sapiens	143-147
9490687-8	1998	Arg517 is part of the Arg-Gly-Asp(RGD) sequence in thrombin and contributes to an ion cluster with aspartic acid residues 552 and 554.	Arginine	0-3	coagulation factor II, thrombin	Homo sapiens	51-59
9523665-12	1998	The subsequent infusion of L-arginine (300 micromol/L) partially reversed the increased tone and significantly (P &lt; 0.01) restored the relaxation induced by BK, Lys-BK and Met-Lys-BK.	Arginine	27-37	kininogen 1	Homo sapiens	160-162
9551089-0	1998	Role of arginine 86 of the insulin receptor in insulin binding and activation of glucose transport.	Arginine	8-16	insulin	Cricetulus griseus	27-34
9512771-1	1998	Nitric oxide (NO) is formed by a class of NO synthases (NOS), which convert arginine into citrulline.	Arginine	76-84	nitric oxide synthase 2	Homo sapiens	42-54
9494104-10	1998	Both the Yap3 and Mkc7 proteases preferred to cleave at a single Glu-Lys downward arrow-Glu-Arg site.	Arginine	92-95	Yap3p	Saccharomyces cerevisiae S288C	9-13
9494104-11	1998	Analysis of secondary cleavage sites showed that Yap3 preferred to cleave after either Lys or Arg and Mkc7 after Lys.	Arginine	94-97	Yap3p	Saccharomyces cerevisiae S288C	49-53
9523665-12	1998	The subsequent infusion of L-arginine (300 micromol/L) partially reversed the increased tone and significantly (P &lt; 0.01) restored the relaxation induced by BK, Lys-BK and Met-Lys-BK.	Arginine	27-37	kininogen 1	Homo sapiens	168-170
9535031-4	1998	As determined by cyclic GMP accumulation, substrate (L-arginine)- and inhibitor (N(G)-monomethyl-L-arginine, NMMA)-sensitive iNOS activity was significantly elevated in CH- or ANI-treated RASMC after 24 h. 3.	Arginine	53-63	nitric oxide synthase 2	Rattus norvegicus	125-129
9523665-12	1998	The subsequent infusion of L-arginine (300 micromol/L) partially reversed the increased tone and significantly (P &lt; 0.01) restored the relaxation induced by BK, Lys-BK and Met-Lys-BK.	Arginine	27-37	kininogen 1	Homo sapiens	168-170
9544420-2	1998	NO is produced from L-arginine by the family of nitric oxide synthase (NOS) enzymes, forming the free radical NO and citrulline as byproduct.	Arginine	20-30	nitric oxide synthase 2	Homo sapiens	48-69
9519735-6	1998	Acute insulin responses to arginine, glucose, and GPAIS were significantly reduced after islet transplantation in both study groups.	Arginine	27-35	insulin	Homo sapiens	6-13
9570506-2	1998	Here, we tested whether tTGase is involved during HT-1080 fibrosarcoma cell apoptosis induced by the YIGSR (Tyr-Ile-Gly-Ser-Arg) peptide.	Arginine	124-127	transglutaminase 2	Homo sapiens	24-30
9566852-1	1998	HOE 901 is a new biosynthetic long-acting human insulin analog (GLY[A21]ARG[B31]ARG[B32]).	Arginine	72-75	insulin	Homo sapiens	48-55
9566852-1	1998	HOE 901 is a new biosynthetic long-acting human insulin analog (GLY[A21]ARG[B31]ARG[B32]).	Arginine	80-83	insulin	Homo sapiens	48-55
9472095-1	1998	The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer.	Arginine	62-70	tumor protein p53	Homo sapiens	20-23
9472095-1	1998	The polymorphism of p53 gene at codon 72 consisting of either arginine (Arg)- or proline (Pro)-encoded allele is suggested to be associated with the susceptibility of tobacco-related lung cancer.	Arginine	72-75	tumor protein p53	Homo sapiens	20-23
9512712-7	1998	In contrast, Pro67--&gt;Arg prevents LexA cleavage while allowing nearly 50% of wild-type induction of UmuD cleavage.	Arginine	24-27	DNA repair system	Escherichia coli	37-41
9524798-2	1998	On the other hand, acetylcholine as well as arginine (ARG) play a major stimulatory role in the neural control of growth hormone (GH) secretion in humans, likely acting via the inhibition of hypothalamic somatostatin release.	Arginine	54-57	growth hormone 1	Homo sapiens	130-132
9524798-11	1998	The GHRH-induced GH rise was also potentiated by ARG in both DS (2,243 +/- 362.4 micrograms/h; p &lt; 0.001 vs. GHRH alone) and NS (2,764.3 +/- 325.7 micrograms/l/h; p &lt; 0.005 vs. GHRH alone).	Arginine	49-52	growth hormone releasing hormone	Homo sapiens	4-8
9524798-11	1998	The GHRH-induced GH rise was also potentiated by ARG in both DS (2,243 +/- 362.4 micrograms/h; p &lt; 0.001 vs. GHRH alone) and NS (2,764.3 +/- 325.7 micrograms/l/h; p &lt; 0.005 vs. GHRH alone).	Arginine	49-52	growth hormone 1	Homo sapiens	4-6
9524798-12	1998	As the percent potentiating effect of ARG in DS was more marked than in NS (425 vs. 308%, respectively), the GH response to GHRH + ARG became similar in both groups.	Arginine	131-134	growth hormone 1	Homo sapiens	109-111
9659350-2	1998	Endogenous NO is synthesised by different isoforms of NO synthase (NOS) from L-arginine.	Arginine	77-87	nitric oxide synthase 2	Homo sapiens	54-65
9485375-6	1998	Proteolysis at Arg572 destroyed the Arg-Gly-Asp (RGD) sequence motif recognized by cell surface alphavbeta3 integrins, and endothelial cell binding to tryptase-modified fibrinogen was significantly reduced, consistent with loss of the RGD motif.	Arginine	15-18	fibrinogen beta chain	Homo sapiens	169-179
9540800-6	1998	It was found that the deduced amino acid sequence of marmoset CYP2E1 in this region is very similar to human CYP2E1, but due to two base differences in the marmoset nucleic acid sequence, the C-terminus of marmoset CYP2E1 is extended by 2 amino acids, i.e. Val-Ile-Pro-Arg-Ser-Ser-Val.	Arginine	269-272	cytochrome P450 2E1	Callithrix jacchus	62-68
9524798-2	1998	On the other hand, acetylcholine as well as arginine (ARG) play a major stimulatory role in the neural control of growth hormone (GH) secretion in humans, likely acting via the inhibition of hypothalamic somatostatin release.	Arginine	44-52	growth hormone 1	Homo sapiens	114-128
9524798-2	1998	On the other hand, acetylcholine as well as arginine (ARG) play a major stimulatory role in the neural control of growth hormone (GH) secretion in humans, likely acting via the inhibition of hypothalamic somatostatin release.	Arginine	44-52	growth hormone 1	Homo sapiens	130-132
9524798-2	1998	On the other hand, acetylcholine as well as arginine (ARG) play a major stimulatory role in the neural control of growth hormone (GH) secretion in humans, likely acting via the inhibition of hypothalamic somatostatin release.	Arginine	54-57	growth hormone 1	Homo sapiens	114-128
9498778-4	1998	Insulin B(5-15) bound to DQ0602 with an apparent KD of 0.7 to 1.0 microM and peptide binding reached equilibrium at 96 h. Single arginine substitutions at each position of the insulin B(5-15) peptide identified amino acids 6, 8, 9, 11, and 14 (relative positions P1, P3, P4, P6, and P9) as important for binding.	Arginine	129-137	insulin	Homo sapiens	176-183
9499087-10	1998	CD4 degradation was also prevented by altering the four Lys residues in its cytosolic domain to Arg, suggesting a role for ubiquitination of one or more of these residues in the process of degradation.	Arginine	96-99	CD4 molecule	Homo sapiens	0-3
9630436-3	1998	IA-4 cDNA is 1,007 bp in length and predicts a protein of 187 amino acids with a molecular mass of 19,940 D. Examination of the amino acid sequence showed a high content of arginine (18.7%), proline (14.4%), alanine (16.0%), leucine (13.4%) and glycine (9.6%).	Arginine	173-181	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	0-4
9740272-3	1998	One case harbored a p53 gene mutation in codon 282 in exon 8, CGG (arginine) to TGG (tryptophan), but the mutation was not found in other patient"s tissues with similar histological features.	Arginine	67-75	tumor protein p53	Homo sapiens	20-23
9540800-8	1998	The expression of CYP2E1 in the marmoset was confirmed by raising an antibody against the deduced C-terminus of marmoset CYP2E1 (Pro-Arg-Ser-Ser-Val).	Arginine	133-136	cytochrome P450 2E1	Callithrix jacchus	18-24
9461491-6	1998	We demonstrate in vitro a novel activity of ACE that removes pairs of basic amino acid residues from a locustamyotropin peptide extended at the C-terminus with either Gly-Lys-Arg or Gly-Arg-Arg, corresponding to a consensus recognition sequence for endoproteolysis of prohormone proteins by prohormone convertases.	Arginine	175-178	angiotensin I converting enzyme	Homo sapiens	44-47
9540800-8	1998	The expression of CYP2E1 in the marmoset was confirmed by raising an antibody against the deduced C-terminus of marmoset CYP2E1 (Pro-Arg-Ser-Ser-Val).	Arginine	133-136	cytochrome P450 2E1	Callithrix jacchus	121-127
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	111-114	angiotensin I converting enzyme	Homo sapiens	242-245
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	111-114	kininogen 1	Homo sapiens	294-304
9461491-6	1998	We demonstrate in vitro a novel activity of ACE that removes pairs of basic amino acid residues from a locustamyotropin peptide extended at the C-terminus with either Gly-Lys-Arg or Gly-Arg-Arg, corresponding to a consensus recognition sequence for endoproteolysis of prohormone proteins by prohormone convertases.	Arginine	186-189	angiotensin I converting enzyme	Homo sapiens	44-47
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	111-114	angiotensin I converting enzyme	Homo sapiens	337-340
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	242-245
9523709-7	1998	Mutants with (a) Leu in positions 71 and 72 (b) Ser or Leu in position 70 and (c) Arg or Tyr in position 73, showed a 4-10-fold higher binding affinity as compared to des-Arg74-[Ala27, Phe67]C5a.	Arginine	82-85	complement C5a receptor 1	Homo sapiens	191-194
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	kininogen 1	Homo sapiens	294-304
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	337-340
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	242-245
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	kininogen 1	Homo sapiens	294-304
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	337-340
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	242-245
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	kininogen 1	Homo sapiens	294-304
9461491-7	1998	The low Km and high kcat values (Km 7.3 and 5.0 microM, kcat 226 and 207 s-1 for the hydrolysis of Phe-Ser-Pro-Arg-Leu-Gly-Lys-Arg and Phe-Ser-Pro-Arg-Leu-Gly-Arg-Arg, respectively) obtained for the hydrolysis of these two peptides by insect ACE means that these peptides, along with mammalian bradykinin, are the most favoured in vitro ACE substrates so far identified.	Arginine	127-130	angiotensin I converting enzyme	Homo sapiens	337-340
9452441-1	1998	Nitric oxide (NO), a physiologically important activator of soluble guanylyl cyclase (sGC), is synthesized from L-arginine and O2 in a reaction catalyzed by NO synthases (NOS).	Arginine	112-122	nitric oxide synthase 2	Homo sapiens	157-169
9448300-8	1998	A glycine-to-arginine missense mutation (G185R) was present in the b Nramp2 gene, but not in the normal allele.	Arginine	13-21	solute carrier family 11 member 2	Rattus norvegicus	69-75
9523923-0	1998	Effects of L-arginine on angiotensin II-related water and salt intakes.	Arginine	11-21	angiotensinogen	Rattus norvegicus	25-39
9523923-3	1998	Intracerebroventricular (icv) injection of L-arginine (L-arg), the precursor for NO, has previously been shown to attenuate both dehydration- and angiotensin II (Ang II)-induced drinking behavior.	Arginine	43-53	angiotensinogen	Rattus norvegicus	146-160
9523923-3	1998	Intracerebroventricular (icv) injection of L-arginine (L-arg), the precursor for NO, has previously been shown to attenuate both dehydration- and angiotensin II (Ang II)-induced drinking behavior.	Arginine	43-53	angiotensinogen	Rattus norvegicus	162-168
9523923-3	1998	Intracerebroventricular (icv) injection of L-arginine (L-arg), the precursor for NO, has previously been shown to attenuate both dehydration- and angiotensin II (Ang II)-induced drinking behavior.	Arginine	43-48	angiotensinogen	Rattus norvegicus	146-160
9523923-3	1998	Intracerebroventricular (icv) injection of L-arginine (L-arg), the precursor for NO, has previously been shown to attenuate both dehydration- and angiotensin II (Ang II)-induced drinking behavior.	Arginine	43-48	angiotensinogen	Rattus norvegicus	162-168
9523923-5	1998	We confirmed that icv administration of L-arg (50 microg) reduced water intakes induced by both 24 h water deprivation and icv Ang II (250 ng).	Arginine	40-45	angiotensinogen	Rattus norvegicus	127-133
9523923-6	1998	We additionally showed that L-arg inhibited the water intake induced by peripheral injection of Ang II and the intake of 0.3 M NaCl following 24 h sodium depletion.	Arginine	28-33	angiotensinogen	Rattus norvegicus	96-102
9452481-5	1998	The 52% decrease in islet TG was accompanied by &gt;30- and 2-fold improvements in glucose- and arginine-stimulated insulin secretion, respectively.	Arginine	96-104	insulin	Homo sapiens	116-123
9530523-8	1998	The results of these experiments demonstrate that: (1) there were mutations in p53 exon 5 and 8 in 35% (14 out of 40 samples) of human renal cancer tissues as revealed by PCR-SSCP analysis; (2) DNA sequencing of samples showing frame-shift have hot spot of p53 mutation on exon 8 at codon 244 (GGC--&gt;TGC) and exon 5 at codon 132 [AAG (Lys)--&gt;AGG (Arg)].	Arginine	353-356	tumor protein p53	Homo sapiens	79-82
9452513-3	1998	Microtubules and Grb2 bind to the carboxyl-terminal proline/arginine-rich domain (PRD), whereas phosphoinositides bind to the pleckstrin homology (PH) domain.	Arginine	60-68	growth factor receptor bound protein 2	Homo sapiens	17-21
9543093-2	1998	A one-nucleotide substitution (G to A) in exon 15, which changes arginine (451) to glutamine in CETP protein, was detected by PCR-SSCP and direct sequencing and screened in the population sample by a simple PCR-based restriction assay.	Arginine	65-73	cholesteryl ester transfer protein	Homo sapiens	96-100
9494699-4	1998	Since arginine, another substance acting via inhibition of SS, maintains its potentiating effect on GH secretion in AN, it has been hypothesized that somewhat specific alteration of the SS-mediated cholinergic influence may be present in this condition.	Arginine	6-14	growth hormone 1	Homo sapiens	100-102
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Arginine	67-70	mitogen-activated protein kinase kinase 4	Homo sapiens	51-55
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Arginine	67-70	mitogen-activated protein kinase 8	Homo sapiens	95-98
9452508-5	1998	Transient expression of a dominant negative mutant SEK1(Lys --&gt; Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis.	Arginine	67-70	mitogen-activated protein kinase 8	Homo sapiens	125-128
9445381-6	1998	However, the trypsin cutting site at the Arg-128 position was less available for digestion in the presence of single-stranded DNA (ssDNA), suggesting that the hAGT protein has a different conformation when bound to ssDNA compared with dsDNA.	Arginine	41-44	angiotensinogen	Homo sapiens	159-163
9653515-0	1998	The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester potentiates insulin secretion stimulated by glucose and L-arginine independently of its action on ATP-sensitive K+ channels.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	4-25
9653515-4	1998	L-arginine-induced insulin release was potentiated by L-NAME.	Arginine	0-10	insulin	Homo sapiens	19-26
9669085-4	1998	Insulin secretion in response to glucose and arginine injection was not affected by heat exposure.	Arginine	45-53	insulin	Homo sapiens	0-7
10993592-7	1998	The potentiating effect of arginine on the GHRH-induced GH response is fully preserved while the stimulatory effect of GHRH + pyridostigmine is reduced in ageing.	Arginine	27-35	growth hormone releasing hormone	Homo sapiens	43-47
9490055-4	1998	At position 83 it had a serine, whereas human t-PA has a free cysteine and rodent t-PA an arginine at this position.	Arginine	90-98	plasminogen activator, tissue type	Homo sapiens	82-86
9558647-1	1998	Nitric oxide (NO) is a free radical gas that is synthesized from L-arginine by NO synthase (NOS).	Arginine	65-75	nitric oxide synthase 2	Homo sapiens	79-90
9514541-7	1998	At a blood glucose of approximately 5 mmol/l the 2-5 min C-peptide response to arginine (CP[ARG]) was similar in all groups, but enhancement of this response by glucose was greater in non-diabetic cirrhotic patients and impaired in diabetic cirrhotic patients.	Arginine	79-87	insulin	Homo sapiens	57-66
9514541-7	1998	At a blood glucose of approximately 5 mmol/l the 2-5 min C-peptide response to arginine (CP[ARG]) was similar in all groups, but enhancement of this response by glucose was greater in non-diabetic cirrhotic patients and impaired in diabetic cirrhotic patients.	Arginine	92-95	insulin	Homo sapiens	57-66
9557822-10	1998	Arginine infusion restores the response of GH to GHRH, in both post-menopausal and obese subjects.	Arginine	0-8	growth hormone 1	Homo sapiens	43-45
9557822-10	1998	Arginine infusion restores the response of GH to GHRH, in both post-menopausal and obese subjects.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	49-53
9557853-2	1998	Nitric oxide (NO) is a mediator of vasodilatation and cytotoxicity which is synthesized from L-arginine by NO synthases (NOS).	Arginine	93-103	nitric oxide synthase 2	Homo sapiens	107-119
9495519-8	1998	This single base substitution changes the codon for arginine (CGA) to an opal stop codon (TGA), resulting in the truncation of the VDR at amino acid 30.	Arginine	52-60	chromogranin A	Homo sapiens	62-65
9490000-7	1998	In combination with an X-ray crystal structure of human lysozyme, it is concluded that the adsorbing site of human lysozyme is at the back of the active site and that Arg-14, Lys-1, Arg-10 and Lys-13 play important roles in binding.	Arginine	182-185	lysozyme	Homo sapiens	56-64
9628395-2	1998	TNF stimulates NO production via expression of inducible NO synthase (iNOS), with L-arginine being the only substrate.	Arginine	82-92	tumor necrosis factor	Mus musculus	0-3
9628395-8	1998	The half-life of TNF mRNA in the presence of NO was roughly half that observed under L-arginine-free conditions (41 min versus 77 min, respectively).	Arginine	85-95	tumor necrosis factor	Mus musculus	17-20
9628395-9	1998	L-citrulline (1 mM), which has been shown to be recycled in RAW 264.7 cells to L-arginine, completely restored attenuation of TNF bioactivity and TNF message to control levels obtained with 1 mM L-arginine.	Arginine	79-89	tumor necrosis factor	Mus musculus	126-129
9628395-9	1998	L-citrulline (1 mM), which has been shown to be recycled in RAW 264.7 cells to L-arginine, completely restored attenuation of TNF bioactivity and TNF message to control levels obtained with 1 mM L-arginine.	Arginine	195-205	tumor necrosis factor	Mus musculus	126-129
10099200-5	1998	The proteolytic cleavage was significantly reduced by the addition of an excess amount of l-arginine (&gt;/=0.2M) to the culture medium, which resulted in a marked improvement in the yield of intact hPTH.	Arginine	90-100	parathyroid hormone	Homo sapiens	199-203
9442050-2	1998	Nitric-oxide synthase (NOS) is a flavohemoprotein that has a cytochrome P450 (P450)-type heme active site and catalyzes the monooxygenation of L-Arg to NG-hydroxy-L-Arg (NHA) according to the normal P450-type reaction in the first step of NO synthesis.	Arginine	143-148	nitric oxide synthase 2	Homo sapiens	0-21
10099200-7	1998	The results demonstrated that l-arginine at high concentrations reduced the rate of hPTH proteolysis by inhibiting extracellular proteases.	Arginine	30-40	parathyroid hormone	Homo sapiens	84-88
9458734-2	1998	After induction of iNOS, L-arginine enhanced NO production in a concentration-dependent manner.	Arginine	25-35	nitric oxide synthase 2	Rattus norvegicus	19-23
10095865-3	1998	NO is produced by the action of NO synthase (NOS) using L-arginine as a substrate.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	32-43
9437321-4	1998	This mutation would be expected to result in an arginine to tryptophan amino acid change in the homeodomain of solurshin, the RIEG/ITX2 gene product.	Arginine	48-56	paired like homeodomain 2	Homo sapiens	111-120
9527014-6	1998	injection of kyotorphin and L-arginine to conscious rats that were normally hydrated or deprived of water for 24 h. In water-sated rats, both L-arginine and kyotorphin increased blood pressure and plasma glucose levels coincident with elevating circulating levels of oxytocin, but not vasopressin.	Arginine	142-152	arginine vasopressin	Rattus norvegicus	285-296
9437321-4	1998	This mutation would be expected to result in an arginine to tryptophan amino acid change in the homeodomain of solurshin, the RIEG/ITX2 gene product.	Arginine	48-56	paired like homeodomain 2	Homo sapiens	126-130
9891755-1	1998	Heterogeneous nuclear RNP protein A1, one of the major proteins in hnRNP particle (precursor for mRNA), is known to be posttranslationally arginine-methylated in vivo on residues 193, 205, 217 and 224 within the RGG box, the motif postulated to be an RNA binding domain.	Arginine	139-147	heterogeneous nuclear ribonucleoprotein D like	Homo sapiens	67-72
10846613-1	1998	OBJECTIVE: We sought to characterize the effects of NG-monomethyl-L-arginine (L-NMMA) and L-arginine (L-Arg) on the pressor response to the infusion of angiotensin II in rats.	Arginine	66-76	angiotensinogen	Rattus norvegicus	152-166
9489597-2	1998	We have therefore studied the effects of pretreatment or concomitant administration of L-arginine on angiotensin II (ANG II)-increased renovascular resistance.	Arginine	87-97	angiotensinogen	Homo sapiens	101-115
9489597-2	1998	We have therefore studied the effects of pretreatment or concomitant administration of L-arginine on angiotensin II (ANG II)-increased renovascular resistance.	Arginine	87-97	angiotensinogen	Homo sapiens	117-123
9421383-6	1998	Both basal and arginine-stimulated insulin levels were increased above the kidney transplant group"s levels and correlated with the mass of CE transferred at 2 h (r = 0.71, P &lt; 0.05; r = 0.66, P &lt; 0.05, respectively).	Arginine	15-23	insulin	Homo sapiens	35-42
15991919-1	1998	Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS), is involved in acute and chronic inflammatory events.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	65-86
10520751-5	1998	Full-length HM-1 is 246 amino acids long, has a predicted MW of 29431, is rich in arginine residues, has a pI of 10.25, and a mean hydrophobicity index of -1.23.	Arginine	82-90	small nuclear ribonucleoprotein U11/U12 subunit 35	Homo sapiens	12-16
10520751-6	1998	HM-1 contains no obvious hydrophobic N-terminal cleavable signal sequence, and no potential N-glycosylation sites, but does contain three highly conserved motifs present in U1-70K splicing factors, and contains numerous C-terminal Arg/Asp and Arg/Glu dipeptides characteristic of "RD" family members that function as regulators of mRNA splicing.	Arginine	231-234	small nuclear ribonucleoprotein U11/U12 subunit 35	Homo sapiens	0-4
10520751-6	1998	HM-1 contains no obvious hydrophobic N-terminal cleavable signal sequence, and no potential N-glycosylation sites, but does contain three highly conserved motifs present in U1-70K splicing factors, and contains numerous C-terminal Arg/Asp and Arg/Glu dipeptides characteristic of "RD" family members that function as regulators of mRNA splicing.	Arginine	243-246	small nuclear ribonucleoprotein U11/U12 subunit 35	Homo sapiens	0-4
9481550-9	1998	In contrast, the increased concentrations of NO metabolites in amniotic fluid and the positive immunostaining of endothelial nitric oxide synthase in the placental villi suggest that the placental L-arginine-NO system is up-regulated in preeclampsia.	Arginine	197-207	nitric oxide synthase 3	Homo sapiens	113-146
9485196-2	1998	It shares CXCR2 with all neutrophil-activating chemokines, which like IL-8 have a conserved Glu-Leu-Arg (ELR) N-terminal motif, but is generally considered to be the only relevant agonist for CXCR1.	Arginine	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
15991919-1	1998	Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS), is involved in acute and chronic inflammatory events.	Arginine	44-49	nitric oxide synthase 2	Homo sapiens	65-86
9658716-1	1998	Nitrix oxide (NO) is a highly reactive and short-lived radical (half-life time: 10-12 s), which is derived from L-arginine by the NO synthases (NOS) in several organ systems.	Arginine	112-122	nitric oxide synthase 2	Homo sapiens	130-142
9595387-2	1998	To clarify the relationships between the second processing step and the third, we introduced point mutation into ET-1 cDNA to replace the Arg in the -4 position of the recognition motifs of furin-like convertase in human preproET-1 (Arg49 or Arg89) by Gly.	Arginine	138-141	endothelin 1	Homo sapiens	113-117
10069444-5	1998	In one case, p53 codon 282 mutation (CGG--&gt;TGG; arg--&gt;trp) were observed in initial diagnosis.	Arginine	51-54	tumor protein p53	Homo sapiens	13-16
9511084-3	1998	Following bacterial infection, especially with Gram-negative organisms, its formation from L-arginine is enhanced due to the cytokine-mediated induction of a NOS enzyme (iNOS) in cells (e.g. cardiac myocytes, vascular smooth muscle) that do not normally have the ability to synthesize NO.	Arginine	91-101	nitric oxide synthase 2	Homo sapiens	170-174
9481683-4	1998	The increase in the Vmax for L-arginine transport (9.0 +/- 1.1) pmol (micrograms protein)-1 min-1) in diabetic endothelial cells cultured in 5 mM D-glucose was unaffected following 24 h exposure to 25 mM D-glucose.	Arginine	29-39	CD59 molecule (CD59 blood group)	Homo sapiens	92-97
9686345-8	1998	As iNOS, AS and AL were co-induced in rat tissues and cells, citrulline-arginine recycling seems to be important in NO synthesis under the conditions of stimulation.	Arginine	72-80	nitric oxide synthase 2	Rattus norvegicus	3-7
9460938-1	1998	Mutants of tobacco vein mottling virus (TVMV) with substitutions of Lys or Arg for Asp in the DAG motif at position 5 in the coat protein (CP) failed to infect tobacco plants systemically, but replicated and produced virions in protoplasts.	Arginine	75-78	golgi phosphoprotein 3	Homo sapiens	125-137
9481683-15	1998	Human insulin reduced the elevated rates of L-arginine transport and cGMP accumulation in diabetic cells cultured in 5 mM D-glucose but failed to reduce increased rates of transport or NO production in cells exposed to 25 mM D-glucose or cycloheximide.	Arginine	44-54	insulin	Homo sapiens	6-13
9405486-6	1997	In an effort to evaluate the role of this enzyme-substrate intermediate in catalysis, we carried out site-directed mutagenesis (Lys to Arg and/or Ala) of the conserved lysine residues in human deoxyhypusine synthase.	Arginine	135-138	deoxyhypusine synthase	Homo sapiens	193-215
9496716-5	1998	L-N(G)-nitroarginine (L-NO-Arg) reduced the response to CCK-OP, an effect which was reversed by L-arginine (L-Arg).	Arginine	96-106	cholecystokinin	Gallus gallus	56-59
9496716-5	1998	L-N(G)-nitroarginine (L-NO-Arg) reduced the response to CCK-OP, an effect which was reversed by L-arginine (L-Arg).	Arginine	108-113	cholecystokinin	Gallus gallus	56-59
9662741-0	1998	Behavioral activity of angiotensin II after stimulation of L-arginine/nitric oxide pathway in rats.	Arginine	59-69	angiotensinogen	Rattus norvegicus	23-37
9662741-1	1998	This study was conducted to determine what, if any, role L-arginine [an endogenous donor of nitric oxide (NO)] plays in the behavioral changes induced by angiotensin II (AII) in rats.	Arginine	57-67	angiotensinogen	Homo sapiens	154-168
9662741-1	1998	This study was conducted to determine what, if any, role L-arginine [an endogenous donor of nitric oxide (NO)] plays in the behavioral changes induced by angiotensin II (AII) in rats.	Arginine	57-67	angiotensinogen	Homo sapiens	170-173
9662741-7	1998	AII, L-arginine and AII with L-arginine applied immediately before the experiment intensified stereotypy evoked by apomorphine at a dose of 1 mg/kg and amphetamine at a dose of 7.5 mg/kg given intraperitoneally.	Arginine	29-39	angiotensinogen	Rattus norvegicus	20-23
9536971-4	1998	PURPOSE: To determine how L-ARG supplementation affects the gene expression of HAS-1 in experimental vein grafts.	Arginine	26-31	LOW QUALITY PROTEIN: hyaluronan synthase 1	Oryctolagus cuniculus	79-84
9536971-10	1998	L-ARG-supplemented animals had a significant decrease in HAS-1 expression at 21 days (0.65 +/- 0.1) compared to nonsupplemented vein grafts (2.82 +/- 0.7) (P &lt; 0.02).	Arginine	0-5	LOW QUALITY PROTEIN: hyaluronan synthase 1	Oryctolagus cuniculus	57-62
9816698-2	1998	is produced from L-arginine, as result of a reaction catalyzed by the enzyme nitric oxide synthase (NOS).	Arginine	17-27	nitric oxide synthase 2	Homo sapiens	77-98
9802559-4	1998	Bacterial lipopolysaccharide (LPS) is a potent inducer of TNF-alpha and inducible nitric oxide synthase (iNOS), which is the specific enzyme for synthesizing NO from L-arginine.	Arginine	166-176	toll-like receptor 4	Mus musculus	30-33
9802559-4	1998	Bacterial lipopolysaccharide (LPS) is a potent inducer of TNF-alpha and inducible nitric oxide synthase (iNOS), which is the specific enzyme for synthesizing NO from L-arginine.	Arginine	166-176	tumor necrosis factor	Mus musculus	58-67
9802559-4	1998	Bacterial lipopolysaccharide (LPS) is a potent inducer of TNF-alpha and inducible nitric oxide synthase (iNOS), which is the specific enzyme for synthesizing NO from L-arginine.	Arginine	166-176	nitric oxide synthase 2, inducible	Mus musculus	72-103
9802559-4	1998	Bacterial lipopolysaccharide (LPS) is a potent inducer of TNF-alpha and inducible nitric oxide synthase (iNOS), which is the specific enzyme for synthesizing NO from L-arginine.	Arginine	166-176	nitric oxide synthase 2, inducible	Mus musculus	105-109
9405602-1	1997	The Glu-134-Arg-135 residues in rhodopsin, located near the cytoplasmic end of the C helix, are involved in G protein binding, or activation, or both.	Arginine	12-15	rhodopsin	Homo sapiens	32-41
9396761-4	1997	Mutation of the single Arg-Gly-Asp (RGD) motif in human L1-Ig6 effectively abrogated binding by the aforementioned integrins.	Arginine	23-26	L1 cell adhesion molecule	Homo sapiens	56-62
9425317-3	1997	The peptides, Arg-Gly-Asp (RGD) and Glu-Ile-Leu-Asp-Val (EILDV) which were reported as active fragments of Fibronectin (a cell adhesion protein), were conjugated with aaPEG (molecular weight, 10,000).	Arginine	14-17	fibronectin 1	Homo sapiens	107-118
9398287-5	1997	Prothrombin contains +3 charge groups (Lys-2, Lys-11, Arg-10) that are absent from the GLA domain (residues 1-35) of protein Z, while protein Z contains -4 charge groups (Gla-11, Asp-34, Asp-35) that are absent in prothrombin.	Arginine	54-57	coagulation factor II, thrombin	Homo sapiens	0-11
9399944-7	1997	L-arginine supplementation enhanced intragraft iNOS mRNA synthesis and iNOS immunoreactivity in capillary endothelial and smooth muscle cells as well as intragraft nitric oxide production.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	47-51
9399944-7	1997	L-arginine supplementation enhanced intragraft iNOS mRNA synthesis and iNOS immunoreactivity in capillary endothelial and smooth muscle cells as well as intragraft nitric oxide production.	Arginine	0-10	nitric oxide synthase 2	Rattus norvegicus	71-75
9395443-0	1997	A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox".	Arginine	120-128	nitric oxide synthase 3	Homo sapiens	69-102
9395443-2	1997	When incubated with solubilized PAEC plasma membrane proteins, eNOS-specific antibody immunoprecipitates CAT1-mediated arginine transport.	Arginine	119-127	nitric oxide synthase 3	Homo sapiens	63-67
9395478-2	1997	Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg-Gly-Asp (RGD) sequence, displayed on specific FNIII repeats.	Arginine	132-135	fibronectin 1	Homo sapiens	50-61
9395443-3	1997	These results document the existence of a caveolar complex between CAT1 and eNOS in PAEC that provides a mechanism for the directed delivery of substrate arginine to eNOS.	Arginine	154-162	nitric oxide synthase 3	Homo sapiens	76-80
9395443-3	1997	These results document the existence of a caveolar complex between CAT1 and eNOS in PAEC that provides a mechanism for the directed delivery of substrate arginine to eNOS.	Arginine	154-162	nitric oxide synthase 3	Homo sapiens	166-170
9395443-4	1997	Direct transfer of extracellular arginine to membrane-bound eNOS accounts for the "arginine paradox" and explains why caveolar localization of eNOS is required for optimal nitric oxide production by endothelial cells.	Arginine	33-41	nitric oxide synthase 3	Homo sapiens	60-64
9395443-4	1997	Direct transfer of extracellular arginine to membrane-bound eNOS accounts for the "arginine paradox" and explains why caveolar localization of eNOS is required for optimal nitric oxide production by endothelial cells.	Arginine	33-41	nitric oxide synthase 3	Homo sapiens	143-147
9395443-4	1997	Direct transfer of extracellular arginine to membrane-bound eNOS accounts for the "arginine paradox" and explains why caveolar localization of eNOS is required for optimal nitric oxide production by endothelial cells.	Arginine	83-91	nitric oxide synthase 3	Homo sapiens	60-64
9400822-4	1997	L-arginine, the physiological substrate for NO synthase (NOS), and NG-nitro-L-arginine methyl ester, an inhibitor of NOS, both caused a 40-50% inhibition of LPS-induced priming of O2- generation in PMNs in stirred suspension, but not in LPS-primed PMNs under static or adherent conditions.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	44-55
9488002-5	1997	TGF beta 1 pretreatment inhibited cytokine-induced expression and activity of nitric oxide synthase in RINm5F cells as determined by Western blotting and by cytosolic conversion of radiolabelled arginine into labelled citrulline and nitric oxide.	Arginine	195-203	transforming growth factor, beta 1	Rattus norvegicus	0-10
9371719-5	1997	gACE from human sperm cleaved Arg-Arg from the C-terminus of the CCK5-GRR (GWMDFGRR), a peptide corresponding to the C-terminus of a CCK-gastrin prohormone intermediate.	Arginine	30-33	cholecystokinin	Homo sapiens	65-68
9371719-5	1997	gACE from human sperm cleaved Arg-Arg from the C-terminus of the CCK5-GRR (GWMDFGRR), a peptide corresponding to the C-terminus of a CCK-gastrin prohormone intermediate.	Arginine	34-37	cholecystokinin	Homo sapiens	65-68
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Arginine	25-28	angiotensin I converting enzyme	Homo sapiens	9-12
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Arginine	29-32	angiotensin I converting enzyme	Homo sapiens	9-12
9423284-1	1997	Modification of arginine residues in bradykinin, [1-5]-bradykinin, splenopentin and two synthetic pentapeptides with acetylacetone (pentane-2,4-dione) significantly increases the relative abundance of sequence-specific fragment ions produced by matrix-assisted laser desorption/ionization (MALDI).	Arginine	16-24	kininogen 1	Homo sapiens	37-47
9423284-1	1997	Modification of arginine residues in bradykinin, [1-5]-bradykinin, splenopentin and two synthetic pentapeptides with acetylacetone (pentane-2,4-dione) significantly increases the relative abundance of sequence-specific fragment ions produced by matrix-assisted laser desorption/ionization (MALDI).	Arginine	16-24	kininogen 1	Homo sapiens	55-65
9548480-7	1997	In contrast, the leech alpha-MSH was flanked at its C-terminal by the Gly-Arg-Lys amidation signal.	Arginine	74-77	proopiomelanocortin	Homo sapiens	23-32
9366309-6	1997	RESULTS: After 2 weeks to 1 month of oral L-arginine treatment, urinary levels of nitric oxide synthase related enzymes and products increased significantly, while levels of the cytokine IL-8 were not changed significantly.	Arginine	42-52	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
9420100-10	1997	L-Arginine decreased alveolar macrophage TNFalpha and IL-1beta release during acute lung injury.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	54-62
9423799-0	1997	Electrospray ionisation mass spectrometry facilitates detection of fibrinogen (Bbeta 14 Arg --&gt; Cys) mutation in a family with thrombosis.	Arginine	88-91	fibrinogen beta chain	Homo sapiens	67-77
9640078-6	1997	The sequencing of PCR products indicated that the loss of Sca I restriction site is caused by T2238--&gt;C transition leading to the translation of ANP with two additional arginines.	Arginine	172-181	suppressor of cancer cell invasion	Homo sapiens	58-63
9640078-6	1997	The sequencing of PCR products indicated that the loss of Sca I restriction site is caused by T2238--&gt;C transition leading to the translation of ANP with two additional arginines.	Arginine	172-181	natriuretic peptide A	Homo sapiens	148-151
9359829-11	1997	Disrupting the N-terminal alpha-helix of Go alpha with a proline point mutation at Arg-9 (R9P) does not affect interactions with G beta gamma on sucrose-density gradients but significantly reduces acceptor membrane binding.	Arginine	83-86	tripartite motif containing 47	Homo sapiens	41-49
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Arginine	115-118	insulin	Homo sapiens	74-81
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Arginine	115-118	insulin	Homo sapiens	242-249
9374504-1	1997	We have recently reported (1) that two naturally occurring mutants of the insulin receptor tyrosine kinase domain, Arg-1174 --&gt; Gln and Pro-1178 --&gt; Leu (Gln-1174 and Leu1178, respectively), both found in patients with inherited severe insulin resistance, markedly impaired receptor tyrosine autophosphorylation, with both mutant receptors being unable to mediate the stimulation of glycogen synthesis or mitogenesis by insulin when expressed in Chinese hamster ovary cells.	Arginine	115-118	insulin	Homo sapiens	242-249
9464453-2	1997	TMX affected the activation of NOS by calmodulin, as it not only inhibited L-arginine oxidation to nitric oxide and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by nNOS.	Arginine	75-85	calmodulin 1	Homo sapiens	38-48
9367520-2	1997	To investigate the specificity and target proteins of the arginine-specific mono-ADP-ribosyltransferase (mADP-RT) in rabbit skeletal muscle T-tubules (TT) biotin- or digoxigenin-coupled NAD-derivatives were synthesized.	Arginine	58-66	ADP-ribosyltransferase 1	Mus musculus	105-112
9367520-6	1997	Under the appropriate reaction conditions, the radioactive [adenylate-14C]NAD and [32P]NAD were found to be solely consumed by the arginine-specific mADP-RT of skeletal muscle TT.	Arginine	131-139	ADP-ribosyltransferase 1	Mus musculus	149-156
9374873-0	1997	Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.	Arginine	43-51	membrane metalloendopeptidase	Homo sapiens	91-101
9374873-0	1997	Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.	Arginine	75-83	membrane metalloendopeptidase	Homo sapiens	91-101
9374873-4	1997	Sequence alignment data shows that Arg-717 of neprilysin could play a similar role to Arg-203 of thermolysin.	Arginine	35-38	membrane metalloendopeptidase	Homo sapiens	46-56
9374873-4	1997	Sequence alignment data shows that Arg-717 of neprilysin could play a similar role to Arg-203 of thermolysin.	Arginine	86-89	membrane metalloendopeptidase	Homo sapiens	46-56
9374873-5	1997	This was investigated by site-directed mutagenesis with Arg-203 of thermolysin and Arg-717 of neprilysin being replaced by methionine residues.	Arginine	83-86	membrane metalloendopeptidase	Homo sapiens	94-104
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Arginine	67-70	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Arginine	104-107	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Arginine	104-107	membrane metalloendopeptidase	Homo sapiens	78-88
9374873-9	1997	The results, coupled with a molecular modeling study, suggest that Arg-717 of neprilysin corresponds to Arg-203 of thermolysin and that in both enzymes a hydrogen bond network exists, involving His-142, Asp-170, and Arg-203 in thermolysin and His-583, Asp-650, and Arg-717 in neprilysin, which is crucial for hydrolytic activity.	Arginine	104-107	membrane metalloendopeptidase	Homo sapiens	78-88
9374664-1	1997	Thrombin receptor is activated by thrombin-mediated cleavage of the receptor"s NH2 terminus between Arg-41 and Ser-42, generating a new NH2 terminus that functions as a "tethered ligand" by binding to sites on the receptor.	Arginine	100-103	coagulation factor II, thrombin	Homo sapiens	0-8
9374664-1	1997	Thrombin receptor is activated by thrombin-mediated cleavage of the receptor"s NH2 terminus between Arg-41 and Ser-42, generating a new NH2 terminus that functions as a "tethered ligand" by binding to sites on the receptor.	Arginine	100-103	coagulation factor II, thrombin	Homo sapiens	34-42
9520124-4	1997	We also determined that r-apo(a) binds directly to a synthetic apoB peptide spanning amino acid residues 3732-3745; this interaction appeared to be mediated by sequences present in apo(a) kringle IV types 8 and 9, and could be inhibited by arginine, lysine and proline.	Arginine	240-248	apolipoprotein B	Homo sapiens	63-67
9374708-1	1997	The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.	Arginine	208-218	nitric oxide synthase 2	Rattus norvegicus	26-57
9374708-1	1997	The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.	Arginine	208-218	nitric oxide synthase 2	Rattus norvegicus	59-63
9374708-1	1997	The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.	Arginine	220-225	nitric oxide synthase 2	Rattus norvegicus	26-57
9374708-1	1997	The induction in vitro of inducible nitric oxide synthase (iNOS) in intact gastric circular (CM) and longitudinal (LM) smooth muscle preparations was evaluated 1) pharmacologically, by the appearance of 1 mM L-arginine (L-Arg)-induced relaxation in a precontracted tissue; 2) biochemically, according to the appearance of iNOS mRNA using a reverse transcriptase-polymerase chain reaction; and 3) immunohistochemically, using an iNOS-specific antibody.	Arginine	220-225	nitric oxide synthase 2	Rattus norvegicus	59-63
9374708-4	1997	The relaxant response to L-Arg in iNOS-induced CM tissues was blocked by the iNOS inhibitor aminoguanidine and by the guanylyl cyclase inhibitor LY-83583.	Arginine	25-30	nitric oxide synthase 2	Rattus norvegicus	34-38
9374708-4	1997	The relaxant response to L-Arg in iNOS-induced CM tissues was blocked by the iNOS inhibitor aminoguanidine and by the guanylyl cyclase inhibitor LY-83583.	Arginine	25-30	nitric oxide synthase 2	Rattus norvegicus	77-81
9409221-10	1997	Modification of LDL arginine and lysine residues abolished the ability of the lipoprotein to interact with APG, a finding that supports the hypothesis that the interaction is dependent on key positively charged amino acids on apoB.	Arginine	20-28	apolipoprotein B	Homo sapiens	226-230
9581555-1	1997	Rat testis NRD convertase (EC 3.4.24.61) is a Zn2+-dependent endopeptidase that cleaves, in vitro, peptide substrates at the N-terminus of Arg residues in dibasic sites.	Arginine	139-142	nardilysin convertase	Homo sapiens	11-25
9438917-8	1997	In HPRL the GH response to GHRH (894.7 +/- 242.4 micrograms 90 min/l) was lower (p &lt; 0.03) than that to HEX (1586.5 +/- 251.3 micrograms 90 min/l) and both were lower (p &lt; 0.03) than that to GHRH + ARG (4468.8 +/- 941.7 micrograms 90 min/l).	Arginine	204-207	growth hormone releasing hormone	Homo sapiens	27-31
9348274-15	1997	GH and EGF combination therapy significantly increased alanine and arginine transport in distal small bowel after 70 % enterectomy but not in the proximal small bowel.	Arginine	67-75	growth hormone 1	Homo sapiens	0-2
9356021-0	1997	Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.	Arginine	55-63	hepatocyte nuclear factor 4 alpha	Homo sapiens	111-143
9356021-0	1997	Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene.	Arginine	55-63	hepatocyte nuclear factor 4 alpha	Homo sapiens	144-149
9356021-8	1997	The decreased ISR to arginine in the ND[+] group compared with the ND[-] group, magnified by glucose potentiation, indicated that HNF-4alpha affects the signaling pathway for arginine-induced insulin secretion.	Arginine	21-29	hepatocyte nuclear factor 4 alpha	Homo sapiens	130-140
9356021-8	1997	The decreased ISR to arginine in the ND[+] group compared with the ND[-] group, magnified by glucose potentiation, indicated that HNF-4alpha affects the signaling pathway for arginine-induced insulin secretion.	Arginine	175-183	hepatocyte nuclear factor 4 alpha	Homo sapiens	130-140
9343420-6	1997	The replacement of three arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding and inhibition of MyoD by M-Twist, while the domain retained other M-Twist functions such as heterodimerization with an E protein and inhibition of MEF2 transactivation.	Arginine	25-33	myocyte enhancer factor 2C	Mus musculus	274-278
9351974-0	1997	The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs.	Arginine	19-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-69
9549298-12	1997	The percentage of CD3 and CD4 subsets significantly (p &lt; 0.05) increased in the L-arginine group than in the placebo group, while the CD8 subset significantly decreased.	Arginine	83-93	CD4 molecule	Homo sapiens	26-29
9549298-13	1997	The CD4/CD8 ratio raised from 1.05 +/- 0.29 to 1.51 +/- 0.46 (p &lt; 0.01) in the L-arginine group, from 1.12 +/- 0.16 to 1.27 +/- 0.24 in the placebo group.	Arginine	82-92	CD4 molecule	Homo sapiens	4-7
9341152-12	1997	For optimal LPC substrate processing activity, an arginine at position P-6 is preferred over an arginine at P-4.	Arginine	50-58	S100 calcium binding protein A12	Homo sapiens	71-74
9352079-4	1997	The experimental results and theoretical analysis suggested that the main contribution to heat stabilization of CPA is related to intramolecular electrostatic interactions and Arginine and/or Lysine are the putative groups able to bind phosphate and stabilize the enzyme molecule against thermal denaturation.	Arginine	176-184	carboxypeptidase A1	Homo sapiens	112-115
9376373-3	1997	In the presence of L-arginine, the physiological substrate, the frequencies of the Fe-Co stretching mode and the C-O stretching mode in nNOS, the brain enzyme, are detected at 503 and 1929 cm-1, respectively; whereas in iNOS, the inducible enzyme from macrophage, the modes are detected at 512 and 1906 cm-1, respectively.	Arginine	19-29	nitric oxide synthase 2	Homo sapiens	220-224
9376373-7	1997	This may be accounted for either by an arginine-CO distance that is as much as 1 A greater in nNOS than in iNOS and eNOS or by a substantial shielding of the charge on the arginine in nNOS as compared to the other isozymes.	Arginine	39-47	nitric oxide synthase 2	Homo sapiens	107-111
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Arginine	40-48	S100 calcium binding protein B	Homo sapiens	68-71
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Arginine	40-48	S100 calcium binding protein B	Homo sapiens	239-242
9325262-3	1997	Binding studies were performed in solution with fluorescein-Phe-Pro-Arg-CH2Cl (FPR)-thrombin.	Arginine	68-71	coagulation factor II, thrombin	Homo sapiens	84-92
9327738-7	1997	The mutant mi allele represents a deletion of an arginine at the basic domain of MITF.	Arginine	49-57	melanogenesis associated transcription factor	Mus musculus	81-85
9334265-2	1997	In oocyte injection assays, CAT3 cRNA exhibited a saturable, sodium ion-independent transport activity with high affinity for L-arginine and L-lysine (Km = 40-60 and 115-165 microM, respectively).	Arginine	126-136	dominant cataract 3	Mus musculus	28-32
9334265-4	1997	The presence of L-arginine in the incubation medium stimulated the efflux rate of L-arginine, indicating that CAT3 is subject to trans-stimulation.	Arginine	16-26	dominant cataract 3	Mus musculus	110-114
9334265-4	1997	The presence of L-arginine in the incubation medium stimulated the efflux rate of L-arginine, indicating that CAT3 is subject to trans-stimulation.	Arginine	82-92	dominant cataract 3	Mus musculus	110-114
9336395-5	1997	N(G)-monomethyl-L-arginine (0.1 mmol/L), an inhibitor of nitric oxide synthase, inhibited the conversion of arginine to citrulline by these cells, blocked insulin-stimulated cGMP production, and blocked the inhibition by insulin of 5-hydroxytryptamine (5-HT)-stimulated Mn+2 (a Ca2+ surrogate) influx and contraction.	Arginine	18-26	insulin	Homo sapiens	155-162
9415273-1	1997	OBJECTIVES: We tested the hypothesis that endothelin-1 (ET-1) aggravates ischaemia/reperfusion injury by stimulating cellular L-arginine depletion, which would result in reduced synthesis of nitric oxide (NO) and withdrawal of cardioprotection.	Arginine	126-136	endothelin 1	Rattus norvegicus	42-54
9415273-1	1997	OBJECTIVES: We tested the hypothesis that endothelin-1 (ET-1) aggravates ischaemia/reperfusion injury by stimulating cellular L-arginine depletion, which would result in reduced synthesis of nitric oxide (NO) and withdrawal of cardioprotection.	Arginine	126-136	endothelin 1	Rattus norvegicus	56-60
9415273-9	1997	CONCLUSION: In ischaemia, ET-1 cause cell necrosis and L-arginine outflow without compromising NO synthesis in this model.	Arginine	55-65	endothelin 1	Rattus norvegicus	26-30
9313765-5	1997	Eight nucleotide substitutions were noted, of which one resulted in the mutation of a conserved arginine residue, Arg127 (CGG)--&gt;Trp (TGG) (designated R127W), located in the T-box, a region of the protein that may play a role in HNF-4 alpha dimerization and DNA binding.	Arginine	96-104	hepatocyte nuclear factor 4 alpha	Homo sapiens	232-243
9370259-5	1997	The C-terminal region of S. mansoni YB-1 differs from the other Y-box binding proteins because of the presence of tandem repeats of Arg and Gly, suggesting the formation of a fibroin-like beta-sandwich structure.	Arginine	132-135	Y-box binding protein 1	Homo sapiens	36-40
9307219-10	1997	Equivalent values for C5a(des Arg) were 6.12 (SMC), 2.98 (cellulose acetate), 11.03 (Cuprophan) and 1.33 ng ml(-1) (low-flux polysulphone).	Arginine	30-33	complement C5a receptor 1	Homo sapiens	22-25
9375972-2	1997	An enhanced production of nitric oxide (NO) from L-arginine, related to the diffuse expression of an inducible NO synthase (iNOS), contributes to the pathogenesis of endotoxic shock.	Arginine	49-59	nitric oxide synthase 2	Rattus norvegicus	101-122
9375972-2	1997	An enhanced production of nitric oxide (NO) from L-arginine, related to the diffuse expression of an inducible NO synthase (iNOS), contributes to the pathogenesis of endotoxic shock.	Arginine	49-59	nitric oxide synthase 2	Rattus norvegicus	124-128
9375972-3	1997	Since iNOS activity depends on extracellular L-arginine, we hypothesized that limiting cellular L-arginine uptake would reduce NO production in endotoxic shock.	Arginine	45-55	nitric oxide synthase 2	Rattus norvegicus	6-10
9375972-3	1997	Since iNOS activity depends on extracellular L-arginine, we hypothesized that limiting cellular L-arginine uptake would reduce NO production in endotoxic shock.	Arginine	96-106	nitric oxide synthase 2	Rattus norvegicus	6-10
9336395-5	1997	N(G)-monomethyl-L-arginine (0.1 mmol/L), an inhibitor of nitric oxide synthase, inhibited the conversion of arginine to citrulline by these cells, blocked insulin-stimulated cGMP production, and blocked the inhibition by insulin of 5-hydroxytryptamine (5-HT)-stimulated Mn+2 (a Ca2+ surrogate) influx and contraction.	Arginine	18-26	insulin	Homo sapiens	221-228
9305973-1	1997	The binding of arginine analogs to endothelial nitric oxide synthase (eNOS, NOSIII) perturbs the environment of the high-spin ferriheme in a highly ligand-specific manner.	Arginine	15-23	nitric oxide synthase 3	Homo sapiens	35-68
9370127-4	1997	In spontaneous hypertension, the production of nitric oxide, which in endothelial cells is formed from L-arginine via the constitutively expressed enzyme endothelial nitric oxide synthase, represents the main mediator of endothelium-dependent vasodilation and seems to be enhanced.	Arginine	103-113	nitric oxide synthase 3	Homo sapiens	154-187
9336332-4	1997	Of the aminoguanidines examined, 2-ethylaminoguanidine was the most efficient inactivator, exhibiting vs. iNOS an apparent KI value of 120 microM as measured at 100 microM arginine and a k(inact max) value of 0.48 min(-1) and thus an apparent second-order rate constant for inactivation of 4.0 mM(-1)min(-1).	Arginine	172-180	nitric oxide synthase 2, inducible	Mus musculus	106-110
9334747-2	1997	Biochemical data on DNA binding by intact ArgR are used as constraints to position the domain on its DNA target and to derive a model for the hexamer-DNA complex using the known structure of the L-arginine-binding domain.	Arginine	195-205	arginine repressor	Escherichia coli	42-46
9355122-1	1997	Nitric oxide (NO) derived from L-arginine by the catalytic action of inducible NO synthase (iNOS) plays an important role in killing parasites.	Arginine	31-41	nitric oxide synthase 2, inducible	Mus musculus	69-90
9355122-1	1997	Nitric oxide (NO) derived from L-arginine by the catalytic action of inducible NO synthase (iNOS) plays an important role in killing parasites.	Arginine	31-41	nitric oxide synthase 2, inducible	Mus musculus	92-96
9305973-1	1997	The binding of arginine analogs to endothelial nitric oxide synthase (eNOS, NOSIII) perturbs the environment of the high-spin ferriheme in a highly ligand-specific manner.	Arginine	15-23	nitric oxide synthase 3	Homo sapiens	76-82
9351523-4	1997	Computer modeling of the thrombin molecule confirmed that arginine 340 is located at the surface of the thrombin molecule, which points to the aqueous solvent.	Arginine	58-66	coagulation factor II, thrombin	Homo sapiens	25-33
9299613-9	1997	First, in the yeast two-hybrid system we mapped two interactive N-terminal regions of EBNA-1, aa 40-60 and aa 325-376, each of which contains arginine-glycine repeats.	Arginine	142-150	EBNA-1	Human gammaherpesvirus 4	86-92
9316505-6	1997	A 120-kDa chymotryptic fragment of fibronectin containing the Arg-Gly-Asp peptide sequence was able to reproduce the effects of the whole fibronectin molecule.	Arginine	62-65	fibronectin 1	Homo sapiens	35-46
9316505-6	1997	A 120-kDa chymotryptic fragment of fibronectin containing the Arg-Gly-Asp peptide sequence was able to reproduce the effects of the whole fibronectin molecule.	Arginine	62-65	fibronectin 1	Homo sapiens	138-149
9351523-4	1997	Computer modeling of the thrombin molecule confirmed that arginine 340 is located at the surface of the thrombin molecule, which points to the aqueous solvent.	Arginine	58-66	coagulation factor II, thrombin	Homo sapiens	104-112
9351523-5	1997	As tryptophan is a highly hydrophobic amino acid, the Arg --&gt; Trp change may be associated with instability of the thrombin molecule.	Arginine	54-57	coagulation factor II, thrombin	Homo sapiens	118-126
9389851-3	1997	We have screened the RYR1 gene in affected individuals for novel MHS mutations by single stranded conformational polymorphism (SSCP) analysis and have identified a G to T transition mutation which results in the replacement of a conserved arginine (Arg) at position 614 with a leucine (Leu).	Arginine	239-247	ryanodine receptor 1	Homo sapiens	21-25
9242548-6	1997	The eNOS transfectants were shown to contain functional enzyme by the conversion of L-arginine to L-citrulline in fractionated cells (P = .0001) and by exposing intact cells to calcium ionophore using the cGMP reporter cell assay (P = .0001).	Arginine	84-94	nitric oxide synthase 3	Homo sapiens	4-8
9389851-3	1997	We have screened the RYR1 gene in affected individuals for novel MHS mutations by single stranded conformational polymorphism (SSCP) analysis and have identified a G to T transition mutation which results in the replacement of a conserved arginine (Arg) at position 614 with a leucine (Leu).	Arginine	249-252	ryanodine receptor 1	Homo sapiens	21-25
9268623-3	1997	Lungfish insulin contains unusual structural features, such as the dipeptide extension to the C-terminus of the A-chain and the substitution Arg --&gt; Asn at position B-23 in the putative receptor binding region of insulin, which may be expected to influence appreciably its biological potency relative to mammalian insulins.	Arginine	141-144	insulin	Homo sapiens	9-16
9268623-3	1997	Lungfish insulin contains unusual structural features, such as the dipeptide extension to the C-terminus of the A-chain and the substitution Arg --&gt; Asn at position B-23 in the putative receptor binding region of insulin, which may be expected to influence appreciably its biological potency relative to mammalian insulins.	Arginine	141-144	insulin	Homo sapiens	216-223
9314409-6	1997	In a separate experiment, L-arginine, the substrate of eNOS, was supplied in drinking water at a concentration of 7.5 g/L for 11 weeks after eNOS gene delivery.	Arginine	26-36	nitric oxide synthase 3	Homo sapiens	55-59
9314409-6	1997	In a separate experiment, L-arginine, the substrate of eNOS, was supplied in drinking water at a concentration of 7.5 g/L for 11 weeks after eNOS gene delivery.	Arginine	26-36	nitric oxide synthase 3	Homo sapiens	141-145
21528246-3	1997	A point mutation was found in the exon D hormone-binding domain of AR leading to substitution of glutamine (GAG) for wild-type arginine (CGG) at codon 629 in 1 (3.4%) hormone-independent stage D2 patient.	Arginine	127-135	androgen receptor	Homo sapiens	67-69
9292004-7	1997	The arginine at position 389 of HST gH was shown to be a determinant of the HHV-6B-specific reactivity of OHV3.	Arginine	4-12	histatin 3	Homo sapiens	32-35
9284898-0	1997	L-arginine but not D-arginine stimulates insulin-mediated glucose uptake.	Arginine	0-10	insulin	Homo sapiens	41-48
9284898-1	1997	Our study aims at investigating a possible role for L-arginine and D-arginine in insulin-mediated glucose uptake.	Arginine	52-62	insulin	Homo sapiens	81-88
9284898-12	1997	In conclusion, L-arginine but not D-arginine stimulates insulin-mediated glucose uptake.	Arginine	15-25	insulin	Homo sapiens	56-63
9284898-13	1997	Nitric oxide (NO), the metabolic mediator for L-arginine, potentiates insulin-mediated glucose uptake through the increase in blood flow.	Arginine	46-56	insulin	Homo sapiens	70-77
9360638-4	1997	The mutation occurred on an allele that encoded arginine at position 112 and this variant was named APOE R112; R251G.	Arginine	48-56	apolipoprotein E	Homo sapiens	100-104
9291099-3	1997	The fourth SCR of both proteins (SCR 4) includes the sequence Arg-Gly-Asp (RGD), a motif that is responsible for the major adhesive activity of matrix proteins like fibronectin.	Arginine	62-65	fibronectin 1	Homo sapiens	165-176
9364253-5	1997	ARG infusion elicited a clear-cut GH increase (peak vs baseline 17.6 +/- 4.7 vs 2.7 +/- 0.8 (g/L, p &lt; 0.01), PRL (20.6 +/- 2.8 vs 6.9 +/- 0.5 (g/L, p &lt; 0.01) and insulin levels (31.4 +/- 5.7 vs 4.5 +/- 2.1 (U/L, p &lt; 0.01) while induced a biphasic variation of plasma glucose levels with early increase (p &lt; 0.01), followed by late decrease below basal values (p &lt; 0.01).	Arginine	0-3	insulin	Homo sapiens	168-175
9364253-10	1997	In conclusion, our present date are against the hypothesis that NO mediates the stimulatory effects of arginine on GH, PRL and insulin secretion.	Arginine	103-111	insulin	Homo sapiens	127-134
9261398-3	1997	In particular, mutation of a glutamic acid residue located at CD4 residue 405 or of arginine and methionine residues located, respectively, at residue 406 and 407 results in a mutant CD4 protein that is efficiently downregulated by HIV-1 Nef but refractory to downregulation by SIV Nef.	Arginine	84-92	CD4 molecule	Homo sapiens	62-65
9261398-3	1997	In particular, mutation of a glutamic acid residue located at CD4 residue 405 or of arginine and methionine residues located, respectively, at residue 406 and 407 results in a mutant CD4 protein that is efficiently downregulated by HIV-1 Nef but refractory to downregulation by SIV Nef.	Arginine	84-92	CD4 molecule	Homo sapiens	183-186
9436257-1	1997	In human, arginine (ARG) induces growth hormone (GH) release, probably via a decrease in somatostatinergic tone.	Arginine	10-18	growth hormone 1	Homo sapiens	33-47
9436257-1	1997	In human, arginine (ARG) induces growth hormone (GH) release, probably via a decrease in somatostatinergic tone.	Arginine	20-23	growth hormone 1	Homo sapiens	33-47
9446323-5	1997	The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups.	Arginine	8-11	tumor protein p53	Homo sapiens	4-7
9446323-5	1997	The p53 Arg/Pro polymorphism study revealed the elevated frequency of Arg allele in lung and stomach cancer groups.	Arginine	70-73	tumor protein p53	Homo sapiens	4-7
9262586-8	1997	The effects of cyclosporin A on endothelium-dependent responses to bradykinin and substance P were overcome by the administration of L-arginine (200 mg/kg intravenously).	Arginine	133-143	kininogen 1	Canis lupus familiaris	67-77
9278100-6	1997	Inhibition of purified iNOS by PCAs could be reversed completely by excess L-arginine, while their inhibition of NO production by stimulated RAW macrophages could be reversed by transfer to a drug-free medium.	Arginine	75-85	nitric oxide synthase 2	Rattus norvegicus	23-27
9313865-3	1997	These values are 12 and 32 times lower than the K(m) for L-arginine with nNOS and iNOS, respectively; however, 7 does not exhibit time-dependent inhibition with either.	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	82-86
9279534-0	1997	Effects of low-dose L-arginine on insulin-mediated vasodilatation and insulin sensitivity.	Arginine	20-30	insulin	Homo sapiens	34-41
9279534-10	1997	Furthermore, L-arginine improves insulin sensitivity in obese patients and NIDDM patients as well as in healthy subjects, indicating a possible mechanism that is different from the restoration of insulin-mediated vasodilatation.	Arginine	13-23	insulin	Homo sapiens	33-40
9279534-1	1997	The present study was carried out to evaluate the effect of a low-dose intravenous supplementation of L-arginine on insulin-mediated vasodilatation and insulin sensitivity.	Arginine	102-112	insulin	Homo sapiens	116-123
9279534-1	1997	The present study was carried out to evaluate the effect of a low-dose intravenous supplementation of L-arginine on insulin-mediated vasodilatation and insulin sensitivity.	Arginine	102-112	insulin	Homo sapiens	152-159
9279534-5	1997	L-Arginine restored the imparied insulin-mediated vasodilatation observed in obesity (22.4 +/- 4.1%, P &lt; 0.01 vs. without L-arginine) and NIDDM (20.3 +/- 3.2%, P &lt; 0.01 vs. without L-arginine).	Arginine	0-10	insulin	Homo sapiens	33-40
9279534-5	1997	L-Arginine restored the imparied insulin-mediated vasodilatation observed in obesity (22.4 +/- 4.1%, P &lt; 0.01 vs. without L-arginine) and NIDDM (20.3 +/- 3.2%, P &lt; 0.01 vs. without L-arginine).	Arginine	125-135	insulin	Homo sapiens	33-40
9279534-5	1997	L-Arginine restored the imparied insulin-mediated vasodilatation observed in obesity (22.4 +/- 4.1%, P &lt; 0.01 vs. without L-arginine) and NIDDM (20.3 +/- 3.2%, P &lt; 0.01 vs. without L-arginine).	Arginine	187-197	insulin	Homo sapiens	33-40
9279534-7	1997	Insulin sensitivity was improved significantly (P &lt; 0.001) in all three groups by infusion of L-arginine.	Arginine	97-107	insulin	Homo sapiens	0-7
9279534-9	1997	Our data indicate that defective insulin-mediated vasodilatation in obesity and NIDDM can be normalized by intravenous L-arginine.	Arginine	119-129	insulin	Homo sapiens	33-40
9288901-2	1997	We have changed three acidic amino acids and two arginine residues that are conserved in the sequence of mammalian PH-20 polypeptides as well as in the hyaluronidases from bee and hornet venom.	Arginine	49-57	sperm adhesion molecule 1	Homo sapiens	115-120
9253350-4	1997	Four to 6 weeks of hyperglycemia induced a severe impairment of glucose- and arginine-induced insulin release, as demonstrated by perfusion of the graft-bearing kidney.	Arginine	77-85	insulin	Homo sapiens	94-101
9253350-7	1997	This, and the similar inhibition of glucose- and arginine-induced insulin release, suggest that prolonged hyperglycemia may exert its deleterious effect on insulin release at a step distal to closure of ATP-sensitive K-channels.	Arginine	49-57	insulin	Homo sapiens	66-73
9253350-7	1997	This, and the similar inhibition of glucose- and arginine-induced insulin release, suggest that prolonged hyperglycemia may exert its deleterious effect on insulin release at a step distal to closure of ATP-sensitive K-channels.	Arginine	49-57	insulin	Homo sapiens	156-163
9253359-5	1997	In this report, genetic analysis of 1 Japanese NSHPT family revealed 2 novel mutations at codon 185 (CGA-->TGA/Arg-->Ter) in exon 4 of the Casr gene and at codon 670 (GGG-->GAG/Gly-->Glu) in exon 7.	Arginine	111-114	calcium sensing receptor	Homo sapiens	47-52
9269530-2	1997	Nitric oxide (NO) plays an important role in the control of glomerular haemodynamics and is synthesized from the amino acid L-arginine by a family of enzymes, NO synthase (NOS).	Arginine	124-134	nitric oxide synthase 2	Homo sapiens	159-170
9253359-5	1997	In this report, genetic analysis of 1 Japanese NSHPT family revealed 2 novel mutations at codon 185 (CGA-->TGA/Arg-->Ter) in exon 4 of the Casr gene and at codon 670 (GGG-->GAG/Gly-->Glu) in exon 7.	Arginine	111-114	calcium sensing receptor	Homo sapiens	139-143
9279753-2	1997	One such point mutation, resulting in the substitution of proline by arginine in a critical region of the linker region between the first and second immunoglobulin-like domains, is associated with highly specific phenotypic consequences in that mutation at this point in FGFR1 results in Pfeiffer syndrome and analogous mutation in FGFR2 results in Apert syndrome.	Arginine	69-77	fibroblast growth factor receptor 1	Homo sapiens	271-276
9233642-3	1997	Incubation of mouse peritoneal cells with L-NMMA, an inhibitor of nitric oxide synthase, or in medium lacking the nitric oxide precursor L-arginine reversed the inhibitory effect of IFN-gamma on Ag-induced serotonin release.	Arginine	137-147	interferon gamma	Mus musculus	182-191
22062323-2	1997	We have developed a visual assay employing the substrate Z-Arg-Arg-NNapOMe for the quantitative detection of active cathepsin B levels in pork thigh muscle homogenates.	Arginine	59-62	cathepsin B	Bos taurus	116-127
9211865-2	1997	The high affinity interaction of integrin alpha5beta1 with the central cell binding domain (CCBD) of fibronectin requires both the Arg-Gly-Asp (RGD) sequence (in the 10th type III repeat) and a second site (in the adjacent 9th type III repeat) which synergizes with RGD.	Arginine	131-134	fibronectin 1	Homo sapiens	101-112
9284407-1	1997	Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide, whereas nitric oxide (NO) is a potent endothelium-derived vasorelaxing factor synthesized from L-arginine by NO synthase (NOS).	Arginine	166-176	nitric oxide synthase 2	Homo sapiens	180-191
9223283-2	1997	More extensive analyses of the disabled mutant revealed a second mutation which disabled US3, a viral gene encoding a protein kinase known to phosphorylate serine/threonine within a specific arginine-rich consensus sequence.	Arginine	191-199	serine/threonine protein kinase US3	Human alphaherpesvirus 1	89-92
9224737-5	1997	The enzyme purified in the presence of both L-Arg and H4B is highly active, with a Vmax of approximately 800 nmol NO min(-1) mg(-1) and a Km for L-Arg of 22 microM.	Arginine	44-49	CD59 molecule (CD59 blood group)	Homo sapiens	117-123
9224737-5	1997	The enzyme purified in the presence of both L-Arg and H4B is highly active, with a Vmax of approximately 800 nmol NO min(-1) mg(-1) and a Km for L-Arg of 22 microM.	Arginine	145-150	CD59 molecule (CD59 blood group)	Homo sapiens	117-123
9312403-1	1997	Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS) is involved in the regulation of several important physiological and pathophysiological functions.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	65-86
9211900-2	1997	A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system.	Arginine	8-11	sorbin and SH3 domain containing 2	Homo sapiens	33-39
9253509-2	1997	Codon 72 of the p53 gene is highly polymorphic with a reported arginine/proline allelotype frequency of 0.65/0.35 for Caucasians and a reversal of this ratio in African-Americans.	Arginine	63-71	tumor protein p53	Homo sapiens	16-19
9312403-1	1997	Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS) is involved in the regulation of several important physiological and pathophysiological functions.	Arginine	44-49	nitric oxide synthase 2	Homo sapiens	65-86
9248702-7	1997	Addition of Arg residues at B31-32, on the backbone of either HI or AspB10 HI, increased affinity for the IGF-I receptor 10 and 28 fold, respectively, compared to HI, confirming the significance of enhanced positive charge at the C-terminal end of the insulin B-chain in increasing selectivity for the IGF-I receptor.	Arginine	12-15	insulin like growth factor 1	Homo sapiens	106-111
9302373-14	1997	In group B, ARG (0.2 g/kg) increased basal GH levels (16.2 +/- 5.2 vs 2.4 +/- 0.6 mU/I; P &lt; 0.03) and potentiated the GH response to GHRH (119.6 +/- 20.4 vs 48.8 +/- 14.2 mU/I; P &lt; 0.01).	Arginine	12-15	growth hormone releasing hormone	Homo sapiens	136-140
9302373-15	1997	In group C, ARG (0.5 g/kg) induced a clear GH rise (28.0 +/- 3.8 vs 2.0 +/- 0.6 mU/I; P &lt; 0.001) and potentiated the GH response to GHRH (93.4 +/- 10.0 vs 34.2 +/- 4.6 mU/I; P &lt; 0.001).	Arginine	12-15	growth hormone releasing hormone	Homo sapiens	135-139
9248702-7	1997	Addition of Arg residues at B31-32, on the backbone of either HI or AspB10 HI, increased affinity for the IGF-I receptor 10 and 28 fold, respectively, compared to HI, confirming the significance of enhanced positive charge at the C-terminal end of the insulin B-chain in increasing selectivity for the IGF-I receptor.	Arginine	12-15	insulin	Homo sapiens	252-259
9199447-4	1997	Purified human fibrinogen and peptides containing the sequence Arg-Gly-Asp (RGD) were also found to promote bacterial invasion of cultured cells.	Arginine	63-66	fibrinogen beta chain	Homo sapiens	15-25
9200011-10	1997	These findings confirm the likely importance of the L-arginine-NO pathway as a physiological mediator of bone cell function and demonstrate that it may be possible to exert differential effects on osteoblast and osteoclast activity in vivo by differential targeting of constitutive and inducible NOS isoforms by selective NOS inhibitors.	Arginine	52-62	nitric oxide synthase 2	Homo sapiens	286-299
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	87-97	nitric oxide synthase 2, inducible	Mus musculus	36-67
9202292-2	1997	In one case, the editing changes a gene-encoded glutamine (Q) to an arginine (R) codon located in the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR-B and also the kainate receptor subunits GluR5 and GluR6.	Arginine	68-76	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	255-260
9237641-2	1997	Unlike competitive inhibitors of L-arginine which inhibited the specific activity of inducible nitric oxide synthase (iNOS) in cell-free extracts, CMTs exerted no such direct effect on the enzyme.	Arginine	33-43	nitric oxide synthase 2, inducible	Mus musculus	85-116
9237641-2	1997	Unlike competitive inhibitors of L-arginine which inhibited the specific activity of inducible nitric oxide synthase (iNOS) in cell-free extracts, CMTs exerted no such direct effect on the enzyme.	Arginine	33-43	nitric oxide synthase 2, inducible	Mus musculus	118-122
9252947-15	1997	CONCLUSIONS: Arginine concentration influences the growth of EMT-6 tumor cells in vitro and dietary arginine supplementation augments tumor growth in vivo.	Arginine	13-21	IL2 inducible T cell kinase	Mus musculus	61-64
9192673-4	1997	It was observed that depletion of cytosolic L-Arg triggers O-2 generation from iNOS.	Arginine	44-49	nitric oxide synthase 2, inducible	Mus musculus	79-83
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	87-97	nitric oxide synthase 2, inducible	Mus musculus	69-73
9192673-5	1997	This iNOS-mediated O-2 generation was blocked by the NOS inhibitor N-nitro-L-arginine methyl ester or by L-Arg, but not by the noninhibitory enantiomer N-nitro-D-arginine methyl ester.	Arginine	105-110	nitric oxide synthase 2, inducible	Mus musculus	5-9
9192673-6	1997	In L-Arg-depleted macrophages iNOS generates both O-2 and NO that interact to form the potent oxidant peroxynitrite (ONOO-), which was detected by luminol luminescence and whose formation was blocked by superoxide dismutase, urate, or L-Arg.	Arginine	3-8	nitric oxide synthase 2, inducible	Mus musculus	30-34
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	87-97	nitric oxide synthase 2, inducible	Mus musculus	75-80
9192673-6	1997	In L-Arg-depleted macrophages iNOS generates both O-2 and NO that interact to form the potent oxidant peroxynitrite (ONOO-), which was detected by luminol luminescence and whose formation was blocked by superoxide dismutase, urate, or L-Arg.	Arginine	235-240	nitric oxide synthase 2, inducible	Mus musculus	30-34
9192673-9	1997	Thus, with reduced L-Arg availability iNOS produces O-2 and ONOO- that modulate macrophage function.	Arginine	19-24	nitric oxide synthase 2, inducible	Mus musculus	38-42
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	99-104	nitric oxide synthase 2, inducible	Mus musculus	36-67
9192673-10	1997	Due to the existence of L-Arg depletion in inflammation, iNOS-mediated O-2 and ONOO- may occur and contribute to cytostatic/cytotoxic actions of macrophages.	Arginine	24-29	nitric oxide synthase 2, inducible	Mus musculus	57-61
9195976-14	1997	Arg regeneration by AS is rate-limiting to NO synthesis and apparently provides iNOS with a preferred cellular source of Arg.	Arginine	0-3	nitric oxide synthase 2	Homo sapiens	80-84
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	99-104	nitric oxide synthase 2, inducible	Mus musculus	69-73
9192673-2	1997	In macrophages NO is synthesized by inducible nitric oxide synthase (iNOS, NOS 2) from L-arginine (L-Arg) and oxygen; however, O-2 was thought to be produced mainly by NADPH oxidase.	Arginine	99-104	nitric oxide synthase 2, inducible	Mus musculus	75-80
9209503-6	1997	In the same animals, anti-P-selectin mAb significantly inhibited neutrophil and monocyte migration to dermal inflammatory reactions induced by zymosan-activated rat serum (ZAS) containing the chemotactic factor C5ades Arg, endotoxin (LPS), interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha).	Arginine	218-221	selectin P	Rattus norvegicus	26-36
9188469-4	1997	Key structural features of the sPLA2 include: (i) a long prepropeptide ending with an arginine doublet, (ii) 16 cysteines located at positions that are characteristic of both group I and group II sPLA2s, (iii) a C-terminal extension typical of group II sPLA2s, (iv) and the absence of elapid and pancreatic loops that are characteristic of group I sPLA2s.	Arginine	86-94	phospholipase A2 group X	Homo sapiens	31-36
9180079-3	1997	Screening libraries of variants of one of these families under affinity-selective conditions yielded a 14-amino acid peptide (Ile-Glu-Gly-Pro-Thr-Leu-Arg-Gln-Trp-Leu-Ala-Ala-Arg-Ala) with high affinity (dissociation constant approximately 2 nanomolar) that stimulates the proliferation of a TPO-responsive Ba/F3 cell line with a median effective concentration (EC50) of 400 nanomolar.	Arginine	150-153	thrombopoietin	Homo sapiens	291-294
9179379-20	1997	On the other hand, when the AM phi had been cultured in the presence of LPS (i.e. high level of iNOS), all the [3H]-L-arginine not metabolized by the inhibited arginase was metabolized to [3H]-L-citrulline.	Arginine	116-126	nitric oxide synthase 2	Rattus norvegicus	96-100
9187098-5	1997	Among p53 mutations at various sites, mutation at codon 242 (C TGC --&gt; C CGC; Cys --&gt; Arg) was specifically observed in both skin cancers and actinic keratoses.	Arginine	92-95	tumor protein p53	Homo sapiens	6-9
9191533-4	1997	Two polymorphisms have previously been characterized in the p21 gene: a C-->A transversion at codon 31 (ser-->arg) and a C-->T transition 20 nucleotides downstream from the 3" end of exon 3.	Arginine	110-113	cyclin dependent kinase inhibitor 1A	Homo sapiens	60-63
9227556-5	1997	Furthermore, inhibition of NO synthase (NOS) attenuated estrogen- or tamoxifen-induced BKCa-channel activity, and this effect was disinhibited by L-arginine.	Arginine	146-156	nitric oxide synthase 2	Homo sapiens	27-38
9182722-0	1997	Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129.	Arginine	115-118	interferon gamma	Homo sapiens	31-47
9182722-0	1997	Interaction of truncated human interferon gamma variants with the interferon gamma receptor: crucial importance of Arg-129.	Arginine	115-118	interferon gamma	Homo sapiens	66-82
9199969-4	1997	Mutations in the amino acid residues Arg 121 and Tyr124, but not Ser125, completely prevented cellular responses mediated by type 2 IL-4 receptors.	Arginine	37-40	interleukin 4	Homo sapiens	132-136
9180639-4	1997	L-arginine (1 x 10(-3) mol/L), reversed the prevention produced by N omega-nitro-L-arginine methyl ester on the increased release of norepinephrine caused by Ang II and Ang-(1-7).	Arginine	0-10	angiotensinogen	Rattus norvegicus	158-164
9199974-8	1997	This Asp, if present, may form a salt bridge with an Arg at position 79 of the alpha-chain and so alter the binding specificity of P9.	Arginine	53-56	Fc gamma receptor and transporter	Homo sapiens	79-90
9191921-8	1997	The proximity of the CD46 downregulating amino acid Arg-243 may suggest a functional link between the domain described here and the CD46 binding domain.	Arginine	52-55	CD46 molecule	Homo sapiens	21-25
9278775-15	1997	The vasopressin V1 receptor antagonist, beta-mercapto-beta,beta-cyclopentamethylenepropionyl-O-Me-Try,Arg) - vasopressin (10 micrograms kg-1; i.v.)	Arginine	102-105	arginine vasopressin	Rattus norvegicus	109-120
9191921-8	1997	The proximity of the CD46 downregulating amino acid Arg-243 may suggest a functional link between the domain described here and the CD46 binding domain.	Arginine	52-55	CD46 molecule	Homo sapiens	132-136
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	121-124	histatin 3	Homo sapiens	9-11
9255042-5	1997	RESULTS: In Patient 1, one substitutional mutation [glutamine (CAA) to arginine (CGA) at position 194] was identified in exon A, and the premature termination of the androgen receptor gene was also demonstrated due to the deletion of one nucleotide at the codon in exon C (position 597).	Arginine	71-79	chromogranin A	Homo sapiens	81-84
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	121-124	histatin 3	Homo sapiens	16-18
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	133-136	histatin 3	Homo sapiens	9-11
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	133-136	histatin 3	Homo sapiens	16-18
9218764-1	1997	The Escherichia coli arginine repressor (ArgR) controls expression of the arginine biosynthetic genes and acts as an accessory protein in Xer site-specific recombination at cer and related plasmid recombination sites.	Arginine	21-29	arginine repressor	Escherichia coli	41-45
9218764-3	1997	In this work, ArgR mutants that are defective in trimer-trimer interactions and bind DNA as trimers in an L-arginine-independent manner are isolated and characterized.	Arginine	106-116	arginine repressor	Escherichia coli	14-18
9218764-4	1997	Whereas the wild-type ArgR hexamer exhibits high-affinity binding to two repeated ARG boxes separated by 3 bp (each ARG box containing two identical dyad symmetrical 9 bp half-sites), the trimeric mutants bind to and footprint three adjacent half-sites of this "idealized" substrate.	Arginine	82-85	arginine repressor	Escherichia coli	22-26
9218764-4	1997	Whereas the wild-type ArgR hexamer exhibits high-affinity binding to two repeated ARG boxes separated by 3 bp (each ARG box containing two identical dyad symmetrical 9 bp half-sites), the trimeric mutants bind to and footprint three adjacent half-sites of this "idealized" substrate.	Arginine	116-119	arginine repressor	Escherichia coli	22-26
9218764-5	1997	Trimeric ArgR is impaired in its ability to repress the arginine biosynthetic genes and in Xer site-specific recombination.	Arginine	56-64	arginine repressor	Escherichia coli	9-13
9704584-1	1997	Constitutively expressed endothelial nitric oxide synthase (ecNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis.	Arginine	99-109	nitric oxide synthase 3	Homo sapiens	25-58
9704584-1	1997	Constitutively expressed endothelial nitric oxide synthase (ecNOS) produces nitric oxide (NO) from L-arginine and is important for the maintenance of cardiovascular homeostasis.	Arginine	99-109	nitric oxide synthase 3	Homo sapiens	60-65
9704589-1	1997	Liver cells can produce nitric oxide from L-arginine through either constitutive NO synthase or inducible NO synthase (NOS) detected after in vivo or in vitro treatment with cytokines and/or lipopolysaccharide (LPS).	Arginine	42-52	nitric oxide synthase 2	Rattus norvegicus	96-117
9188742-7	1997	Correlation of the C5a tertiary structure with mutational analyses clarifies the significance of the functional and binding properties of Arg 62 and suggests that both Arg 62 and Arg 74 interact at the same binding site on the receptor.	Arginine	138-141	complement C5a receptor 1	Homo sapiens	19-22
9188742-7	1997	Correlation of the C5a tertiary structure with mutational analyses clarifies the significance of the functional and binding properties of Arg 62 and suggests that both Arg 62 and Arg 74 interact at the same binding site on the receptor.	Arginine	168-171	complement C5a receptor 1	Homo sapiens	19-22
9188742-7	1997	Correlation of the C5a tertiary structure with mutational analyses clarifies the significance of the functional and binding properties of Arg 62 and suggests that both Arg 62 and Arg 74 interact at the same binding site on the receptor.	Arginine	168-171	complement C5a receptor 1	Homo sapiens	19-22
9153260-8	1997	Thrombin specifically cleaved chicken OPN at two sites: between Arg-22 and Ser-23, which generated the 5-kDa N-terminal end fragment, and another between Lys-138 and Ala-139, which generated the 30- and 20-kDa fragments.	Arginine	64-67	secreted phosphoprotein 1	Gallus gallus	38-41
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Arginine	198-201	coagulation factor II, thrombin	Homo sapiens	64-72
10497625-2	1997	DESIGN: Arginine-induced insulin and glucagon release tested at two glucose levels before and after 3 days of intensive insulin treatment.	Arginine	8-16	insulin	Homo sapiens	25-32
10497625-2	1997	DESIGN: Arginine-induced insulin and glucagon release tested at two glucose levels before and after 3 days of intensive insulin treatment.	Arginine	8-16	insulin	Homo sapiens	120-127
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	20-27
9202399-10	1997	Thus, in culture medium with lower amounts of L-arginine, L-NMMA blocked the IFN-gamma-induced inhibition of GHRH-stimulated GH release at a lower dose.	Arginine	46-56	interferon gamma	Homo sapiens	77-86
9202399-10	1997	Thus, in culture medium with lower amounts of L-arginine, L-NMMA blocked the IFN-gamma-induced inhibition of GHRH-stimulated GH release at a lower dose.	Arginine	46-56	growth hormone releasing hormone	Homo sapiens	109-113
9202399-11	1997	The inhibition of PRL and GH release by IFN-gamma was markedly reduced in L-arginine-depleted medium.	Arginine	74-84	prolactin	Homo sapiens	18-21
9202399-11	1997	The inhibition of PRL and GH release by IFN-gamma was markedly reduced in L-arginine-depleted medium.	Arginine	74-84	interferon gamma	Homo sapiens	40-49
9210463-0	1997	The N-terminal Arg-rich region of human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef is involved in RNA binding.	Arginine	15-18	nef protein	Simian immunodeficiency virus	111-114
9176264-6	1997	Coincubation with L-arginine (200 microM) or the .NO mimic spermine-NO (1 microM) prevented the ablation of the response to TNF-alpha by aminoguanidine.	Arginine	18-28	tumor necrosis factor	Homo sapiens	124-133
25850327-4	1997	The inducible form of nitric oxide synthase (iNOS) mediates the synthesis of NO and L-citrulline from L-arginine.	Arginine	102-112	nitric oxide synthase 2, inducible	Mus musculus	45-49
9153287-11	1997	Emulsion-associated and free apoE bound approximately two molecules of LPS, possibly by its exposed hydrophilic domain involving arginine residues.	Arginine	129-137	apolipoprotein E	Homo sapiens	29-33
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	143-150
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	143-150
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	143-150
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	143-150
9133539-3	1997	We observed that 1) insulin dose-dependently increases NO production, evaluated as citrulline synthesis from L-arginine (n = 4, P = 0.015); 2) insulin dose-dependently increases not only cGMP but also cAMP: for instance, after 8 min of insulin incubation at 1,920 pmol/l, cAMP increased from 39.8 +/- 1.4 to 121.3 +/- 12.6 pmol/10(9) platelets (n = 16, P = 0.0001); 3) when insulin is incubated for 120 min, the increase of cGMP and cAMP shows a plateau between 2 and 20 min, and while the effect on cGMP is significant until 120 min, the effect on cAMP is no more significant at 60 and 120 min; 4) insulin increases the effects on cAMP of the adenylate cyclase agonists Iloprost and forskolin (n = 5, P = 0.0001) and enhances their platelet anti-aggregating effects (n = 6 and 8, respectively; P = 0.0001); and 5) the inhibition of NO synthase by N(G)-monomethyl-L-arginine blunts both the insulin effects on basal cGMP and cAMP (n = 4) and those on the Iloprost- and forskolin-induced cAMP increase (n = 5).	Arginine	109-119	insulin	Homo sapiens	143-150
9228206-4	1997	In PRL-treated islets, the 45Ca2+ content after a 5 min incubation in the presence of G, Leu, Arg and Cch was significantly higher than the control only in islets cultured for 19 days.	Arginine	94-97	prolactin	Rattus norvegicus	3-6
9182989-0	1997	Human ribosomal protein L7 binds RNA with an alpha-helical arginine-rich and lysine-rich domain.	Arginine	59-67	ribosomal protein L7	Homo sapiens	6-26
9228206-5	1997	Except with Arg, the 45Ca2+ uptake in PRL-treated islets after a 90 min incubation was also significantly higher than the control only in islets cultured for 19 days.	Arginine	12-15	prolactin	Rattus norvegicus	38-41
9168467-3	1997	At least one of the rGR proto-NLSs appears to influence receptor trafficking within the nucleus, as revealed by a unique nuclear staining pattern of receptors possessing a point mutation (i.e., arginine at position 496; R496), at proto-NLS, pNLS-2.	Arginine	194-202	retinal G protein coupled receptor	Rattus norvegicus	20-23
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Arginine	188-196	insulin	Homo sapiens	23-30
9176854-5	1997	This missense mutation denotes amino acid substitution of the proline residue for arginine residue at position 145 of apo E.	Arginine	82-90	apolipoprotein E	Homo sapiens	118-123
9192729-4	1997	Using three fusion proteins containing different parts of the amino-terminal domain of human LBR, it was shown that the stretch comprising amino acids 1 to 89, which contains a Ser-Arg rich region (RS region), binds to nucleoplasmin and that the binding was inhibited by a common NLS-peptide.	Arginine	181-184	lamin B receptor	Homo sapiens	93-96
9168138-7	1997	A protein encoded by the WS-3 gene has an R-G-D (Arg-Gly-Asp) motif in the N-terminal region, which seems to confer adhesive properties to macromolecular proteins like fibronectin.	Arginine	49-52	dynactin subunit 6	Homo sapiens	25-29
9165669-4	1997	Nitric oxide (NO) is an oxidant formed by the catalysis of L-arginine when acted upon by the enzyme nitric oxide synthase (NOS).	Arginine	59-69	nitric oxide synthase 2	Homo sapiens	100-121
9184448-9	1997	This AR mutation is a G to A transition at nucleotide 2677 that leads to substitution of glutamine (CAG) for the wild type arginine (CGG) at codon 629.	Arginine	123-131	androgen receptor	Homo sapiens	5-7
9136868-0	1997	Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.	Arginine	125-133	nitric oxide synthase 2, inducible	Mus musculus	58-89
9136868-1	1997	The oxygenase domain of the mouse cytokine-inducible nitric-oxide synthase (iNOSox, amino acids 1-498) binds heme, tetrahydrobiopterin, and the substrate Arg and is the domain responsible for catalyzing nitric oxide synthesis and maintaining the enzyme"s active dimeric structure.	Arginine	154-157	nitric oxide synthase 2, inducible	Mus musculus	43-74
9168138-7	1997	A protein encoded by the WS-3 gene has an R-G-D (Arg-Gly-Asp) motif in the N-terminal region, which seems to confer adhesive properties to macromolecular proteins like fibronectin.	Arginine	49-52	fibronectin 1	Homo sapiens	168-179
9144413-1	1997	Nitric oxide (NO) is a biologically active molecule known to be enzymatically synthesized from L-arginine in the presence of NO synthetase (NOS).	Arginine	95-105	nitric oxide synthase 2	Homo sapiens	125-138
9108031-2	1997	To map the interface of the bimolecular interaction between hormone and receptor, we designed and radioiodinated a bioactive, photoreactive PTH agonist, (125)I-[Nle(8,18),Lys13(epsilon-p-(3-I-Bz)Bz),L-2-Nal(23),Arg(26,2 7),Tyr34] bPTH-(1-34)NH2 ((125)I-all-R-K13).	Arginine	211-214	parathyroid hormone	Homo sapiens	140-143
9092503-9	1997	This suggests that mammalian Kex2-like serine proteases may process pro-CCK at single arginine residues.	Arginine	86-94	cholecystokinin	Homo sapiens	72-75
9109669-1	1997	The substrate binding site in nitric oxide synthase (NOS) can accommodate the physiological substrates, L-arginine and N(omega)-hydroxy L-arginine as well as many substrate analogues and inhibitors.	Arginine	104-114	nitric oxide synthase 2	Homo sapiens	30-51
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Arginine	69-72	inorganic pyrophosphatase 1	Homo sapiens	47-50
9083063-7	1997	The double PGHS-1 His513 --&gt; Arg, Ile523 --&gt; Val mutant became more sensitive to inhibition by NS-398 and DFU than the single IV mutant, and time-dependent inhibition was observed.	Arginine	32-35	prostaglandin-endoperoxide synthase 1	Homo sapiens	11-17
9083028-7	1997	A CCK-BR mutant was further constructed by replacing five amino acids, Gly-Leu-Ser-Arg-(Arg)-Leu, in the first intracellular loop with the corresponding five CCK-AR specific amino acids, Ile-Arg-Asn-Lys-(Arg)-Met.	Arginine	83-86	cholecystokinin B receptor	Homo sapiens	2-8
9083028-7	1997	A CCK-BR mutant was further constructed by replacing five amino acids, Gly-Leu-Ser-Arg-(Arg)-Leu, in the first intracellular loop with the corresponding five CCK-AR specific amino acids, Ile-Arg-Asn-Lys-(Arg)-Met.	Arginine	88-91	cholecystokinin B receptor	Homo sapiens	2-8
9083063-0	1997	Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --&gt; Arg and Ile523 --&gt; val mutation.	Arginine	125-128	prostaglandin-endoperoxide synthase 1	Homo sapiens	14-42
9083063-0	1997	Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --&gt; Arg and Ile523 --&gt; val mutation.	Arginine	125-128	prostaglandin-endoperoxide synthase 2	Homo sapiens	71-77
9083063-2	1997	These residues of human PGHS-1 were each mutated to the corresponding PGHS-2 residues (His513 --&gt; Arg and Ile523 --&gt; Val) and a double mutant (His513 --&gt; Arg,Ile523 --&gt; Val) containing both residues was also constructed.	Arginine	101-104	prostaglandin-endoperoxide synthase 1	Homo sapiens	24-30
9083063-2	1997	These residues of human PGHS-1 were each mutated to the corresponding PGHS-2 residues (His513 --&gt; Arg and Ile523 --&gt; Val) and a double mutant (His513 --&gt; Arg,Ile523 --&gt; Val) containing both residues was also constructed.	Arginine	163-166	prostaglandin-endoperoxide synthase 1	Homo sapiens	24-30
9083028-7	1997	A CCK-BR mutant was further constructed by replacing five amino acids, Gly-Leu-Ser-Arg-(Arg)-Leu, in the first intracellular loop with the corresponding five CCK-AR specific amino acids, Ile-Arg-Asn-Lys-(Arg)-Met.	Arginine	88-91	cholecystokinin B receptor	Homo sapiens	2-8
9128204-11	1997	pretreatment with the angiotensin II type 1 receptor antagonist CV-11974 inhibited the pressor response to 10 micromol L-arginine and the first phase of the pressor response to 10 micromol D-arginine.	Arginine	119-129	angiotensin II receptor, type 1b	Rattus norvegicus	22-52
9092833-16	1997	Hence, hydrophilic lysine residues in hAK1 would appear to be essential for substrate-enzyme interaction with the coordination of some arginine residues, reported previously [Kim, H. J., et al.	Arginine	135-143	adenylate kinase 1	Homo sapiens	38-42
9108789-1	1997	A glutamine-for-arginine substitution at amino acid position 3500 of apolipoprotein B (apo B) causes synthesis of LDL with reduced binding affinity to the LDL receptor (LDLR).	Arginine	16-24	apolipoprotein B	Homo sapiens	69-85
9108789-1	1997	A glutamine-for-arginine substitution at amino acid position 3500 of apolipoprotein B (apo B) causes synthesis of LDL with reduced binding affinity to the LDL receptor (LDLR).	Arginine	16-24	apolipoprotein B	Homo sapiens	87-92
9155960-1	1997	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	193-211
9173879-2	1997	Further characterization of this reaction with cells expressing an arginine-specific, glycosylphosphatidylinositol-anchored, mono-ADP-ribosyltransferase demonstrated that FGF-2 is ADP-ribosylated on arginine.	Arginine	67-75	fibroblast growth factor 2	Homo sapiens	171-176
9173879-2	1997	Further characterization of this reaction with cells expressing an arginine-specific, glycosylphosphatidylinositol-anchored, mono-ADP-ribosyltransferase demonstrated that FGF-2 is ADP-ribosylated on arginine.	Arginine	199-207	fibroblast growth factor 2	Homo sapiens	171-176
9155960-1	1997	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	213-217
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	204-207	complement C5a receptor 1	Homo sapiens	23-26
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	204-207	complement C5a receptor 1	Homo sapiens	27-30
9146932-7	1997	The major peak of NCA was found to contain immunoreactive C5a/C5a des Arg and chemotaxis.	Arginine	70-73	complement C5a receptor 1	Homo sapiens	58-61
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	204-207	complement C5a receptor 1	Homo sapiens	27-30
9146932-7	1997	The major peak of NCA was found to contain immunoreactive C5a/C5a des Arg and chemotaxis.	Arginine	70-73	complement C5a receptor 1	Homo sapiens	62-65
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	204-207	complement C5a receptor 1	Homo sapiens	27-30
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	35-38	complement C5a receptor 1	Homo sapiens	23-26
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	35-38	complement C5a receptor 1	Homo sapiens	27-30
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	153-156	apolipoprotein E	Homo sapiens	0-4
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	35-38	complement C5a receptor 1	Homo sapiens	27-30
9146932-9	1997	Purified serum derived C5a/C5a des Arg was found to have altered chromatographic properties when added to BAL fluid; this suggested that BAL fluid contained proteins which interacted with the C5a/C5a des Arg.	Arginine	35-38	complement C5a receptor 1	Homo sapiens	27-30
9112018-1	1997	We report a homozygous missense mutation at position 1092 (substitution of glutamine for arginine) in the tyrosine kinase domain of the insulin receptor in a patient with leprechaunism associated with severe insulin resistance and intrauterine growth retardation.	Arginine	89-97	insulin	Homo sapiens	136-143
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	81-84	apolipoprotein E	Homo sapiens	0-4
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	81-84	apolipoprotein E	Homo sapiens	61-65
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	81-84	apolipoprotein E	Homo sapiens	61-65
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	153-156	apolipoprotein E	Homo sapiens	61-65
9057348-3	1997	APOE*3 is the most common allele, coding for the product E3; APOE*2 codes for an Arg-158--&gt;Cys substitution (E2), and APOE*4 codes for a Cys-112--&gt;Arg product (E4).	Arginine	153-156	apolipoprotein E	Homo sapiens	61-65
9363643-0	1997	Unusual effect of clusters of rare arginine (AGG) codons on the expression of human interferon alpha 1 gene in Escherichia coli.	Arginine	35-43	interferon alpha 1	Homo sapiens	84-102
9178029-8	1997	We conclude that 1) the elevated IR-GHRH in the cord blood plasma originates from the fetus and may have a primary role in enhancing secretion of GH which promotes growth in early human life, and 2) the participations of GHRH in the mechanisms of GH secretion seen after administrations of L-dopa, L-arginine and somatostatin are different.	Arginine	298-308	growth hormone releasing hormone	Homo sapiens	36-40
9178029-8	1997	We conclude that 1) the elevated IR-GHRH in the cord blood plasma originates from the fetus and may have a primary role in enhancing secretion of GH which promotes growth in early human life, and 2) the participations of GHRH in the mechanisms of GH secretion seen after administrations of L-dopa, L-arginine and somatostatin are different.	Arginine	298-308	growth hormone 1	Homo sapiens	36-38
9178029-8	1997	We conclude that 1) the elevated IR-GHRH in the cord blood plasma originates from the fetus and may have a primary role in enhancing secretion of GH which promotes growth in early human life, and 2) the participations of GHRH in the mechanisms of GH secretion seen after administrations of L-dopa, L-arginine and somatostatin are different.	Arginine	298-308	growth hormone releasing hormone	Homo sapiens	221-225
9154300-2	1997	While Arginine (Arg)719Tryptophan (Trp) mutation in the beta-myosin heavy chain (MyHC) gene is associated with a high incidence of sudden cardiac death (SCD), the Valine (Val)606Methionine (Met) mutation in the same gene is associated with a near normal life expectancy.	Arginine	6-14	myosin heavy chain 6	Homo sapiens	56-79
9154300-2	1997	While Arginine (Arg)719Tryptophan (Trp) mutation in the beta-myosin heavy chain (MyHC) gene is associated with a high incidence of sudden cardiac death (SCD), the Valine (Val)606Methionine (Met) mutation in the same gene is associated with a near normal life expectancy.	Arginine	6-14	myosin heavy chain 6	Homo sapiens	81-85
9154300-2	1997	While Arginine (Arg)719Tryptophan (Trp) mutation in the beta-myosin heavy chain (MyHC) gene is associated with a high incidence of sudden cardiac death (SCD), the Valine (Val)606Methionine (Met) mutation in the same gene is associated with a near normal life expectancy.	Arginine	6-9	myosin heavy chain 6	Homo sapiens	56-79
9154300-2	1997	While Arginine (Arg)719Tryptophan (Trp) mutation in the beta-myosin heavy chain (MyHC) gene is associated with a high incidence of sudden cardiac death (SCD), the Valine (Val)606Methionine (Met) mutation in the same gene is associated with a near normal life expectancy.	Arginine	6-9	myosin heavy chain 6	Homo sapiens	81-85
9181551-9	1997	In conclusion, BSP mediated attachment of osteoblastic cells to hydroxyapatite, and this activity could be accomplished only by the poly-Glu sequence and the Arg-Gly-Asp sequence.	Arginine	158-161	integrin binding sialoprotein	Homo sapiens	15-18
9103529-4	1997	A23187, bradykinin or substance P increased NO synthesis from L-arginine by EC in the presence or absence of L-glutamine.	Arginine	62-72	tachykinin precursor 1	Bos taurus	22-33
9601833-9	1997	Relations between the altered insulin sensitivity and arginine, the precursor of nitrogen oxide, apparent only in PHT could be a stimulus for seeking associations with endothelial damage described in insulin resistant conditions.	Arginine	54-62	insulin	Homo sapiens	30-37
9601833-9	1997	Relations between the altered insulin sensitivity and arginine, the precursor of nitrogen oxide, apparent only in PHT could be a stimulus for seeking associations with endothelial damage described in insulin resistant conditions.	Arginine	54-62	insulin	Homo sapiens	200-207
9065469-8	1997	The neutralization of prothrombinase activity coincided with cleavages at Arg-506 and subsequent cleavage at Arg-306 of the factor Va heavy chain by activated protein C. Thus, the protein C pathway combined with TFPI creates a minimal inhibitory potential required to shut down TF-initiated thrombin generation.	Arginine	74-77	coagulation factor II, thrombin	Homo sapiens	25-33
9065469-8	1997	The neutralization of prothrombinase activity coincided with cleavages at Arg-506 and subsequent cleavage at Arg-306 of the factor Va heavy chain by activated protein C. Thus, the protein C pathway combined with TFPI creates a minimal inhibitory potential required to shut down TF-initiated thrombin generation.	Arginine	109-112	coagulation factor II, thrombin	Homo sapiens	25-33
9065418-6	1997	Acetylated and cyclohexanedione-treated LDL did not bind to decorin, demonstrating that both lysine and arginine residues of apoB-100 are necessary for the interaction.	Arginine	104-112	apolipoprotein B	Homo sapiens	125-133
9045621-1	1997	Nitric oxide (NO) and L-citrulline are formed from the oxidation of L-arginine by three different isoforms of NO synthase (NOS).	Arginine	68-78	nitric oxide synthase 2	Homo sapiens	110-121
9135136-2	1997	The location of the integrin binding sequence Arg-Gly-Asp (RGD) on human type 2 adenovirus (Ad2) was visualized by cryo-electron microscopy (cryo-EM) and image reconstruction using a mAb (DAV-1) which recognizes a linear epitope, IRGDTFATR.	Arginine	46-49	apolipoprotein E	Homo sapiens	92-95
9045635-2	1997	This enzyme (RS kinase) specifically phosphorylates arginine-serine dipeptide motifs located at the NH2-terminal domain of LBR and regulates its interactions with other nuclear envelope proteins.	Arginine	52-60	lamin B receptor	Homo sapiens	123-126
9070661-4	1997	In these cells, wild type for the p53 gene, we have overexpressed the mutant p53(175(Arg&gt;His)) protein leading to a p53 mutant phenotype, as verified by the absence of a G1 arrest after gamma-irradiation.	Arginine	85-88	tumor protein p53	Homo sapiens	34-37
9070661-4	1997	In these cells, wild type for the p53 gene, we have overexpressed the mutant p53(175(Arg&gt;His)) protein leading to a p53 mutant phenotype, as verified by the absence of a G1 arrest after gamma-irradiation.	Arginine	85-88	tumor protein p53	Homo sapiens	77-80
9070661-4	1997	In these cells, wild type for the p53 gene, we have overexpressed the mutant p53(175(Arg&gt;His)) protein leading to a p53 mutant phenotype, as verified by the absence of a G1 arrest after gamma-irradiation.	Arginine	85-88	tumor protein p53	Homo sapiens	77-80
9060826-6	1997	iNOS activity was demonstrated biochemically by measuring the calcium-independent generation of citrulline from L-arginine, and the presence of iNOS mRNA was demonstrated using reverse transcriptase polymerase chain reaction.	Arginine	112-122	nitric oxide synthase 2	Homo sapiens	0-4
9041254-6	1997	Furthermore, a CGC--&gt;CAC transition in the p53 gene of the adenoma resulted in an Arg--&gt;His missense mutation in codon 175.	Arginine	85-88	tumor protein p53	Homo sapiens	46-49
9056177-5	1997	A comparison with a data base suggested that the sequence is very similar to des-arg9bradykinin (arg-pro-pro-gly-phe-ser-pro-phe).	Arginine	81-84	kininogen 1	Homo sapiens	85-95
9056177-10	1997	In conclusion, the existence of des-arg9[hyp3]-bradykinin (arg-pro-hyp-gly-phe-ser-pro-phe) in human plasma is described.	Arginine	36-39	kininogen 1	Homo sapiens	47-57
9065782-0	1997	Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype.	Arginine	72-80	prostaglandin E receptor 3	Homo sapiens	153-156
9118999-5	1997	ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes.	Arginine	250-253	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
9118999-5	1997	ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes.	Arginine	281-284	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
9118999-6	1997	The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg).	Arginine	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
9118999-6	1997	The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg).	Arginine	39-42	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
9118999-6	1997	The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg).	Arginine	206-209	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
9118999-6	1997	The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg).	Arginine	206-209	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
9119020-2	1997	To further clarify the mechanism of processing in the biosynthesis of endothelin-1, we introduced a point mutation into endothelin-1 cDNA to replace the Arg in the -4 position of the recognition motifs of furin-like convertase in human preproendothelin-1 (Arg49 or Arg89) by Gly.	Arginine	153-156	endothelin 1	Homo sapiens	70-82
9119020-3	1997	When mutant cDNAs were expressed in Chinese hamster ovary (CHO)-K1 cells, they failed to be processed at the mutated processing signal, suggesting that the Arg-Ser-Lys-Arg motifs of preproendothelin-1 are recognized by CHO-K1 furin-like convertase.	Arginine	156-159	endothelin 1	Homo sapiens	182-200
9119020-3	1997	When mutant cDNAs were expressed in Chinese hamster ovary (CHO)-K1 cells, they failed to be processed at the mutated processing signal, suggesting that the Arg-Ser-Lys-Arg motifs of preproendothelin-1 are recognized by CHO-K1 furin-like convertase.	Arginine	168-171	endothelin 1	Homo sapiens	182-200
9117019-5	1997	This effect was paralleled by an increase in calcium-independent iNOS activity, assessed by measuring the conversion of radiolabeled L-arginine to L-citrulline, in LPS-treated animals.	Arginine	133-143	nitric oxide synthase 2	Rattus norvegicus	65-69
9163848-8	1997	In this disease, apo E Sendai which results from new substitution (Arginine 145--&gt;Proline) may induce intraglomerular lipoprotein thrombi characteristic of lipoprotein glomerulopathy.	Arginine	67-75	apolipoprotein E	Homo sapiens	17-22
9050929-4	1997	Sequencing of the gene-specific PCR products showed that the three common ORM1 alleles result from A--&gt;G transitions at the codons for amino acid positions 20 in exon 1 and 156 in exon 5 of the AGP1 gene: ORM1*F1 was characterized by CAG (Gln) and GTG (Val), ORM1*F2, by CAG (Gln) and ATG (Met), and ORM1*S, by CGG (Arg) and GTG (Val).	Arginine	319-322	orosomucoid 1	Homo sapiens	74-78
9050929-4	1997	Sequencing of the gene-specific PCR products showed that the three common ORM1 alleles result from A--&gt;G transitions at the codons for amino acid positions 20 in exon 1 and 156 in exon 5 of the AGP1 gene: ORM1*F1 was characterized by CAG (Gln) and GTG (Val), ORM1*F2, by CAG (Gln) and ATG (Met), and ORM1*S, by CGG (Arg) and GTG (Val).	Arginine	319-322	orosomucoid 1	Homo sapiens	197-201
9050929-4	1997	Sequencing of the gene-specific PCR products showed that the three common ORM1 alleles result from A--&gt;G transitions at the codons for amino acid positions 20 in exon 1 and 156 in exon 5 of the AGP1 gene: ORM1*F1 was characterized by CAG (Gln) and GTG (Val), ORM1*F2, by CAG (Gln) and ATG (Met), and ORM1*S, by CGG (Arg) and GTG (Val).	Arginine	319-322	orosomucoid 1	Homo sapiens	208-215
9050929-4	1997	Sequencing of the gene-specific PCR products showed that the three common ORM1 alleles result from A--&gt;G transitions at the codons for amino acid positions 20 in exon 1 and 156 in exon 5 of the AGP1 gene: ORM1*F1 was characterized by CAG (Gln) and GTG (Val), ORM1*F2, by CAG (Gln) and ATG (Met), and ORM1*S, by CGG (Arg) and GTG (Val).	Arginine	319-322	orosomucoid 1	Homo sapiens	208-212
9050929-4	1997	Sequencing of the gene-specific PCR products showed that the three common ORM1 alleles result from A--&gt;G transitions at the codons for amino acid positions 20 in exon 1 and 156 in exon 5 of the AGP1 gene: ORM1*F1 was characterized by CAG (Gln) and GTG (Val), ORM1*F2, by CAG (Gln) and ATG (Met), and ORM1*S, by CGG (Arg) and GTG (Val).	Arginine	319-322	orosomucoid 1	Homo sapiens	208-212
9130760-6	1997	The IL-1beta-stimulated NO production was inhibited by the NOS inhibitor, L-NMMA, whose effects were reversed by L-arginine.	Arginine	113-123	interleukin 1 beta	Rattus norvegicus	4-12
9054946-2	1997	Recently, two mutations in the cystatin B gene (also known as stefin B, STFB) mapping to 21q22.3 have been implicated in the EPM1 phenotype: a G--&gt;C substitution in the last nucleotide of intron 1 that was predicted to cause a splicing defect in one family, and a C--&gt;T substitution that would change an Arg codon (CGA) to a stop codon (TGA) at amino acid position 68, resulting in a truncated cystatin B protein in two other families.	Arginine	310-313	cystatin B	Homo sapiens	31-41
9054946-2	1997	Recently, two mutations in the cystatin B gene (also known as stefin B, STFB) mapping to 21q22.3 have been implicated in the EPM1 phenotype: a G--&gt;C substitution in the last nucleotide of intron 1 that was predicted to cause a splicing defect in one family, and a C--&gt;T substitution that would change an Arg codon (CGA) to a stop codon (TGA) at amino acid position 68, resulting in a truncated cystatin B protein in two other families.	Arginine	310-313	cystatin B	Homo sapiens	72-76
9054946-2	1997	Recently, two mutations in the cystatin B gene (also known as stefin B, STFB) mapping to 21q22.3 have been implicated in the EPM1 phenotype: a G--&gt;C substitution in the last nucleotide of intron 1 that was predicted to cause a splicing defect in one family, and a C--&gt;T substitution that would change an Arg codon (CGA) to a stop codon (TGA) at amino acid position 68, resulting in a truncated cystatin B protein in two other families.	Arginine	310-313	cystatin B	Homo sapiens	125-129
9030556-6	1997	In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) was relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 microM and 50 microM, respectively.	Arginine	137-147	nitric oxide synthase 3	Homo sapiens	50-65
9038155-2	1997	Since shortening the side chains of Trp-800, Arg-812, and Leu-813 in smooth muscle myosin light chain kinase abrogated calmodulin-dependent activation (Bagchi, I. C., Huang, Q., and Means, A. R. (1992) J. Biol.	Arginine	45-48	calmodulin 1	Homo sapiens	119-129
9038155-4	1997	267, 3024-3029), substitutions were introduced at positions in calmodulin which contact residues corresponding to Arg-812 and Leu-813 in the smooth muscle myosin light chain kinase peptide.	Arginine	114-117	calmodulin 1	Homo sapiens	63-73
9030556-6	1997	In contrast, inhibition of human neuronal NOS and endothelial NOS (eNOS) was relatively weaker, rapidly reversible, and competitive with L-arginine, with Ki values of 2 microM and 50 microM, respectively.	Arginine	137-147	nitric oxide synthase 3	Homo sapiens	67-71
9054767-7	1997	Preincubation of the aortic segments with L-arginine raised by twofold both baseline [NO] and [NO] stimulated by addition of 2.5 micrograms/mL VEGF/VPF.	Arginine	42-52	vascular endothelial growth factor A	Homo sapiens	143-147
9030612-1	1997	Previous studies have shown that fibrinogen can associate with endothelial cells via an Arg-Gly-Asp (RGD) recognition specificity.	Arginine	88-91	fibrinogen beta chain	Homo sapiens	33-43
9030597-5	1997	In the present study, we provide the first functional characterization of a point mutation located in the central part of RYR1, Gly2434 --&gt; Arg.	Arginine	143-146	ryanodine receptor 1	Homo sapiens	122-126
9098989-0	1997	Quantitation of an orally available thrombin inhibitor in rat, monkey and human plasma and in human urine by high-performance liquid chromatography and fluorescent post-column derivatization of arginine.	Arginine	194-202	coagulation factor II	Rattus norvegicus	36-44
9054767-7	1997	Preincubation of the aortic segments with L-arginine raised by twofold both baseline [NO] and [NO] stimulated by addition of 2.5 micrograms/mL VEGF/VPF.	Arginine	42-52	vascular endothelial growth factor A	Homo sapiens	148-151
9033393-4	1997	The new inhibitor contained a tryptophan side chain instead of the arginine side chain that is present in the prototypical thrombin inhibitors.	Arginine	67-75	coagulation factor II	Rattus norvegicus	123-131
9024155-8	1997	Expression of VCAM-1 was reduced only in the stimulated state and only in the presence of 1000 mumol/L L-arginine (72 +/- 24%, P = .02).	Arginine	103-113	vascular cell adhesion molecule 1	Homo sapiens	14-20
9013619-8	1997	The conserved Phe and Arg in P450BM-3 were substituted by Leu112 and Asp439, respectively in PGIS.	Arginine	22-25	prostaglandin I2 synthase	Homo sapiens	93-97
9124436-2	1997	In the present study, we have found that the inhibition of NO production in bovine endothelial cells by an L-arginine competitive antagonist induces DNA replication and promotes the transition from prereplicative to replicative phases of the endothelial cell cycle and an increase in c-myc and c-fos oncogene-encoded protein expression.	Arginine	107-117	MYC proto-oncogene, bHLH transcription factor	Bos taurus	284-289
9053451-4	1997	Analysis of 16 CD59 mutants with single, highly nonconservative substitutions suggests that CD59 has a single active site that includes Trp-40, Arg-53, and Glu-56 of the glycosylated, membrane-distal face of the disk-like extra-cellular domain and, possibly, Asp-24 positioned at the edge of the domain.	Arginine	144-147	CD59 molecule (CD59 blood group)	Homo sapiens	15-19
9053451-4	1997	Analysis of 16 CD59 mutants with single, highly nonconservative substitutions suggests that CD59 has a single active site that includes Trp-40, Arg-53, and Glu-56 of the glycosylated, membrane-distal face of the disk-like extra-cellular domain and, possibly, Asp-24 positioned at the edge of the domain.	Arginine	144-147	CD59 molecule (CD59 blood group)	Homo sapiens	92-96
9124393-0	1997	Effect of nitric oxide synthase inhibition on renal hemodynamics in humans: reversal by L-arginine.	Arginine	88-98	nitric oxide synthase 2	Homo sapiens	10-31
9124393-1	1997	Animal experiments indicate that inhibition of nitric oxide synthase (NOS) influences renal hemodynamics and that this effect can be reversed by L-arginine, the precursor of NO synthesis.	Arginine	145-155	nitric oxide synthase 2	Homo sapiens	47-68
9040948-5	1997	Using Western and Northern blot analysis and arginine conversion assay, we demonstrate that the expression of iNOS decreases when cells undergo differentiation.	Arginine	45-53	nitric oxide synthase 2	Homo sapiens	110-114
9049485-9	1997	Metabolic investigations performed in successful cases showed an early phase of insulin release after arginine, mild and reversible postprandial hyperglycaemia and normal HbA1c levels.	Arginine	102-110	insulin	Homo sapiens	80-87
9056390-2	1997	In the present experiments we found that S-methylthiocitrulline, a relatively selective neuronal nitric oxide synthase (NOS) inhibitor, produced significant neuroprotection against striatal lesions produced by malonate, and the protection was reversed by l-arginine but not by d-arginine.	Arginine	255-265	nitric oxide synthase 2	Homo sapiens	97-118
9045906-6	1997	Similar to other B27 subtypes, these peptides are mainly nonamers with an Arg at position P2.	Arginine	74-77	melanocortin 2 receptor accessory protein	Homo sapiens	17-20
9052744-12	1997	Transfection of the ADPRT coding sequence into EL4 cells results in expression of the enzyme as a functional GPI-anchored cell-surface protein, able to ADP-ribosylate the arginine analog agmatine as well as cell-surface molecules.	Arginine	171-179	ADP-ribosyltransferase 1	Mus musculus	20-25
9059765-0	1997	Insulin responses to intravenous glucose, intravenous arginine and a hyperglycaemic clamp in ICA-positive subjects with different degrees of glucose tolerance.	Arginine	54-62	insulin	Homo sapiens	0-7
9059765-4	1997	Acute insulin response to IVGTT and insulin and C-peptide responses to the hyperglycaemic clamp and the arginine bolus were dramatically lower (p &lt; 0.001) in diabetic and IGT subjects than in ICA-positive patients with normal glucose tolerance and control subjects.	Arginine	104-112	insulin	Homo sapiens	6-13
9024239-5	1997	The acute insulin response (AIR) to 5 g iv arginine was increased by GLP-1 at 14 mmol/L glucose (P = 0.028), and the slopeAIR, i.e., the glucose potentiation of insulin secretion, was markedly increased by GLP-1 (P = 0.028).	Arginine	43-51	insulin	Homo sapiens	10-17
9024239-5	1997	The acute insulin response (AIR) to 5 g iv arginine was increased by GLP-1 at 14 mmol/L glucose (P = 0.028), and the slopeAIR, i.e., the glucose potentiation of insulin secretion, was markedly increased by GLP-1 (P = 0.028).	Arginine	43-51	glucagon	Homo sapiens	69-74
9024239-6	1997	Plasma glucagon levels were reduced by GLP-1 (P = 0.028), and arginine-stimulated glucagon secretion (AGR) was inhibited by GLP-1 at 14 (P = 0.046) and 28 mmol/L glucose (P = 0.028).	Arginine	62-70	glucagon	Homo sapiens	124-129
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 3	Homo sapiens	90-110
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 3	Homo sapiens	112-116
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	174-192
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 2	Homo sapiens	194-198
9013984-11	1997	Similarly, IL-1beta-induced apoptosis and inhibition of actin expression were inhibited by this arginine analogue.	Arginine	96-104	interleukin 1 beta	Rattus norvegicus	11-19
9203626-1	1997	We characterized a new iodinated, high affinity, linear V1a vasopressin antagonist, phenylacetylD-Tyr(Et)Phe-Gln-Asn-Lys-Pro-Arg-Tyr-NH2.	Arginine	125-128	arginine vasopressin	Rattus norvegicus	60-71
9022076-6	1997	In study III, the plasma insulin response to L-arginine was reestablished; this was associated with hemodynamic and rheologic changes following L-arginine not significantly different from those recorded in study I.	Arginine	45-55	insulin	Homo sapiens	25-32
9022076-6	1997	In study III, the plasma insulin response to L-arginine was reestablished; this was associated with hemodynamic and rheologic changes following L-arginine not significantly different from those recorded in study I.	Arginine	144-154	insulin	Homo sapiens	25-32
9701047-8	1997	Thus, the enzymatic synthesis of NO from L-arginine by endothelial NOS appears to be partially regulated by binding of both calmodulin and substrate.	Arginine	41-51	calmodulin	Bos taurus	124-134
9089816-5	1997	The increased thrombin-inhibitory activity of M37 may be due to the presence of an arginine in the linker from the thrombin receptor which may interact with one of two glutamic acid residues located at the exit of the thrombin substrate binding pocket.	Arginine	83-91	coagulation factor II, thrombin	Homo sapiens	14-22
9089816-5	1997	The increased thrombin-inhibitory activity of M37 may be due to the presence of an arginine in the linker from the thrombin receptor which may interact with one of two glutamic acid residues located at the exit of the thrombin substrate binding pocket.	Arginine	83-91	coagulation factor II, thrombin	Homo sapiens	115-123
9089816-5	1997	The increased thrombin-inhibitory activity of M37 may be due to the presence of an arginine in the linker from the thrombin receptor which may interact with one of two glutamic acid residues located at the exit of the thrombin substrate binding pocket.	Arginine	83-91	coagulation factor II, thrombin	Homo sapiens	115-123
9812835-4	1997	Increase of L-Arg transport induced by tumor necrosis factor-alpha (TNF alpha) in SMC of SHR was obviously lower than that in WKY rats (P &lt; 0.01).	Arginine	12-17	tumor necrosis factor	Rattus norvegicus	39-66
9812835-4	1997	Increase of L-Arg transport induced by tumor necrosis factor-alpha (TNF alpha) in SMC of SHR was obviously lower than that in WKY rats (P &lt; 0.01).	Arginine	12-17	tumor necrosis factor	Rattus norvegicus	68-77
9053847-6	1997	Moreover, detection of ThaI polymorphism of codon 72 showed that MCF-7 cells predominantly express wild-type p53 with proline, while mutated p53 in MCF-7/Adr cells contains an arginine residue at codon 72.	Arginine	176-184	tumor protein p53	Homo sapiens	141-144
9084577-1	1997	BACKGROUND: Besides endothelial cells, platelets possess active nitric oxide synthase (NOS) enzyme, which converts L-arginine to NO and L-citrulline.	Arginine	115-125	nitric oxide synthase 2	Homo sapiens	64-85
9084577-4	1997	METHODS AND RESULTS: Nitric oxide synthase activity was measured as formation of L-citrulline from L-arginine.	Arginine	99-109	nitric oxide synthase 2	Homo sapiens	21-42
9030829-1	1997	Prompted by the recent findings that a tryptophan to arginine (Trp64Arg) mutation in the beta3-adrenergic receptor gene was associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, with abdominal obesity and insulin resistance in Finns, and with an increased capacity to gain weight in French whites, we studied the prevalence of this mutation in 231 diabetic and 95 nondiabetic Japanese subjects and assessed its contribution to the development of obesity and NIDDM.	Arginine	53-61	insulin	Homo sapiens	164-171
9018048-5	1997	In contrast to hirudin, the dissociation constants (Ki) for S195A with serpins (antithrombin, protease nexin-1 and alpha1-antitrypsin with a P1 arginine) were 2 x 10(3) to 2 x 10(5)-fold higher than those observed with thrombin.	Arginine	144-152	serpin family A member 1	Homo sapiens	115-133
8995387-6	1997	At position -5, the selectivity was quite different among the various isozymes; PKC alpha, -gamma, and -delta selected peptides with Arg at this position while other PKC isozymes selected hydrophobic amino acids such as Phe, Leu, or Val.	Arginine	133-136	protein kinase C alpha	Homo sapiens	80-109
9005995-8	1997	Molecular modeling demonstrated the disruption of hydrophobic interactions in the interior of the triple helix critical for spectrin function caused by the replacement of the hydrophobic, uncharged leucine by a hydrophilic, positively charged arginine.	Arginine	243-251	karst	Drosophila melanogaster	124-132
8995418-5	1997	Two arginine substitution variants were found to be more active than wild-type Rs-AFP2 in media with high ionic strength.	Arginine	4-12	defensin-like protein 2	Raphanus sativus	79-86
8995387-6	1997	At position -5, the selectivity was quite different among the various isozymes; PKC alpha, -gamma, and -delta selected peptides with Arg at this position while other PKC isozymes selected hydrophobic amino acids such as Phe, Leu, or Val.	Arginine	133-136	protein kinase C alpha	Homo sapiens	80-83
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Arginine	65-68	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
8995232-11	1997	We conclude that apoE inhibits platelet aggregation through the L-arginine:NO signal transduction pathway.	Arginine	64-74	apolipoprotein E	Homo sapiens	17-21
9016333-6	1997	The structures of membrane-bound [Thr6]-bradykinin developed here provide experimental support for the interaction of residues 7 and 8 with the core of the membrane-bound receptor and the N-terminus and C-terminal arginine interacting with the extracellular portion of the receptor.	Arginine	214-222	kininogen 1	Homo sapiens	40-50
9584848-1	1997	The active site lysine residue, K256, involved in Schiff"s base linkage with pyridoxal-5"-phosphate (PLP) in sheep liver recombinant serine hydroxymethyltransferase (rSHMT) was changed to glutamine or arginine by site-directed mutagenesis.	Arginine	201-209	serine hydroxymethyltransferase 1	Rattus norvegicus	166-171
9413508-7	1997	The inhibition of IFN gamma-induced NO-synthesis with NMA or with arginine free medium did not affect the virus replication.	Arginine	66-74	interferon gamma	Mus musculus	18-27
8995232-0	1997	Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway.	Arginine	59-69	apolipoprotein E	Homo sapiens	0-16
9131896-5	1997	Similar GH responses were observed in normal controls and alcoholic subjects when GHRH or arginine were administered.	Arginine	90-98	growth hormone 1	Homo sapiens	8-10
9404643-8	1997	As for other peptide precursors in endocrine cells, the conversion of POMC in P19 cells was inhibited by the biosynthetic replacement of its arginine residues by the analog canavanine.	Arginine	141-149	proopiomelanocortin	Homo sapiens	70-74
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Arginine	73-76	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Arginine	73-76	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9250363-4	1997	The optimal substrate peptide for Pim-1 was determined to be Lys/Arg-Lys/Arg-Arg-Lys/Arg-Leu-Ser/Thr-X, where X is an amino acid residue with a small side chain.	Arginine	73-76	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
9059567-9	1997	In contrast, the drug produced a partial but significant decrease in the insulin response to L-arginine.	Arginine	93-103	insulin	Homo sapiens	73-80
9059567-10	1997	In fact, the mean peak insulin response to L-arginine was 5.3 times (53 +/- 5 mU/l (mean +/- SE)) higher than basal value (10 +/- 2) in the absence of L-NAME, but only 3.33 times (40 +/- 4) higher than baseline (12 +/- 3) during the infusion of the NOS-inhibitor.	Arginine	43-53	insulin	Homo sapiens	23-30
9155591-4	1997	RESULTS: The histopathological damage in the liver, and the concanavalin A induced release of TNF alpha and IL6 were significantly inhibited by the synthetic Arg-Gly-Asp mimetic (p &lt; 0.001).	Arginine	158-161	tumor necrosis factor	Mus musculus	94-103
9020366-7	1997	The arginine residue is conserved in both the erythroid and housekeeping ALAS genes in all known vertebrate sequences.	Arginine	4-12	5'-aminolevulinate synthase 1	Homo sapiens	73-77
10481377-10	1997	Pretreatment with L-Arginine, the substrate of NO-synthase reversed the hemodynamic, but not motility effects of neurotensin.	Arginine	18-28	neurotensin	Canis lupus familiaris	113-124
9155591-4	1997	RESULTS: The histopathological damage in the liver, and the concanavalin A induced release of TNF alpha and IL6 were significantly inhibited by the synthetic Arg-Gly-Asp mimetic (p &lt; 0.001).	Arginine	158-161	interleukin 6	Mus musculus	108-111
9155581-1	1997	BACKGROUND: Nitric oxide (NO) is an unstable vasodilator formed by NO synthetase (NOS) from L-arginine (L-Arg) in various cells but its role in the control of pancreatic secretion in humans has not been examined.	Arginine	92-102	nitric oxide synthase 2	Homo sapiens	67-80
9155581-1	1997	BACKGROUND: Nitric oxide (NO) is an unstable vasodilator formed by NO synthetase (NOS) from L-arginine (L-Arg) in various cells but its role in the control of pancreatic secretion in humans has not been examined.	Arginine	104-109	nitric oxide synthase 2	Homo sapiens	67-80
9039115-1	1997	The infusion of L-arginine induces the production of nitric oxide and stimulates the immediate secretion of insulin.	Arginine	16-26	insulin	Homo sapiens	108-115
9155581-8	1997	L-NMMA alone resulted in a significant fall in plasma insulin and pancreatic polypeptide levels, while L-Arg added to pancreatic secretagogue infusion caused a significant increase of plasma insulin and pancreatic polypeptide levels above those attained with secretagogues alone.	Arginine	103-108	insulin	Homo sapiens	191-198
9155581-9	1997	After the addition of L-Arg to L-NMMA, both plasma insulin and pancreatic polypeptide levels rose significantly above the levels observed with L-NMMA plus secretin-CCK stimulation.	Arginine	22-27	insulin	Homo sapiens	51-58
9039115-2	1997	To examine the relationship between insulin resistance and endothelium-dependent vascular relaxation in patients with essential hypertension, we evaluated the renal and insulin responses to L-arginine, 500 mg/kg infused intravenously over 30 minutes, in 23 patients with mild essential hypertension who were neither obese nor diabetic and in 20 normotensive control subjects.	Arginine	190-200	insulin	Homo sapiens	169-176
9039115-9	1997	A link may be present between the abnormality of the L-arginine/nitric oxide/cyclic GMP pathway and insulin resistance in patients with essential hypertension.	Arginine	53-63	insulin	Homo sapiens	100-107
9058199-5	1997	The amino acid sequence of peptide I was determined to be LIEDNEYTAR, which is identical with the sequence from Leu-418 through Arg-427 of mouse c-Yes, indicating that one of the autophosphorylation sites corresponds to Tyr-424 of the mouse c-Yes.	Arginine	128-131	YES proto-oncogene 1, Src family tyrosine kinase	Rattus norvegicus	145-150
9020384-5	1997	A novel germline p53 mutation was identified at codon 133 (ATG-->AGG) in exon 5, resulting in the substitution of arginine for methionine, in all four cancer-affected individuals and in three apparently healthy individuals.	Arginine	114-122	tumor protein p53	Homo sapiens	17-20
9120775-9	1997	These studies suggest that the glycoprotein IIb/IIIa complex, present on activated-platelets, may interact with fibronectin and vitronectin substrates through the Arg-Gly-Asp-dependent mechanism.	Arginine	163-166	fibronectin 1	Homo sapiens	112-123
8985414-4	1997	Deleting a Tyr-Arg-Tyr-Leu sequence in this region or changing these residues to Ala prevents CD46 down regulation from the infected cell surface.	Arginine	15-18	CD46 molecule	Homo sapiens	94-98
9230468-6	1997	The possibility of a beta-turn structure for the crucial Gly-Pro-Gly-Arg sequence has been confirmed by 2D NMR experiments.	Arginine	69-72	amyloid beta precursor protein	Homo sapiens	19-25
9395248-1	1997	Nitric oxide (NO), first identified as endothelium-derived relaxing factor (EDRF), is a free radical synthesized from L-arginine by NO synthases (NOS).	Arginine	118-128	nitric oxide synthase 2	Homo sapiens	132-144
9328230-1	1997	Nitric oxide (NO) is generated from L-arginine by different isoforms of the enzyme nitric oxide synthase (NOS) and is known to be involved in mediating several biological functions, some of which are associated with reproduction.	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	83-104
9199488-1	1997	Novel, non-arginine based compounds have been identified as potent inhibitors of nitric oxide synthase (NOS).	Arginine	11-19	nitric oxide synthase 2	Homo sapiens	81-102
9000231-3	1997	All species degraded the cathepsin B substrate Z-Arg-Arg-NMec, but distinct species differences were observed with respect to pH optima and buffer preferences.	Arginine	49-52	cathepsin B	Bos taurus	25-36
9097298-7	1997	Similar GH responses were observed in normal controls and parkinsonian patients when GH-RH or arginine were administered.	Arginine	94-102	growth hormone 1	Homo sapiens	8-10
9466952-1	1997	The effects of arginine on nitric oxide synthase (NOS) activity and NO production were studied in pulmonary artery endothelial cells (PAEC).	Arginine	15-23	nitric oxide synthase 2	Homo sapiens	27-48
9478195-1	1997	Mammalian tRNA 3" processing endoribonuclease (3" tRNase) can recognize pre-tRNA-like complexes between a 5" half tRNA(Arg) and a 3" half tRNA(Arg) with a 3" trailer, and can cleave the 3" half tRNA(Arg) after the discriminator nucleotide (Nashimoto M., 1996, RNA, 2:523-534).	Arginine	119-122	elaC ribonuclease Z 1	Homo sapiens	10-45
9000231-4	1997	The cathepsin B and L substrate Z-Phe-Arg-NMec was similarly degraded by all species, and activity was abolished by the cysteine proteinase inhibitor E-64.	Arginine	38-41	cathepsin B	Bos taurus	4-15
9478195-1	1997	Mammalian tRNA 3" processing endoribonuclease (3" tRNase) can recognize pre-tRNA-like complexes between a 5" half tRNA(Arg) and a 3" half tRNA(Arg) with a 3" trailer, and can cleave the 3" half tRNA(Arg) after the discriminator nucleotide (Nashimoto M., 1996, RNA, 2:523-534).	Arginine	143-146	elaC ribonuclease Z 1	Homo sapiens	10-45
9478195-1	1997	Mammalian tRNA 3" processing endoribonuclease (3" tRNase) can recognize pre-tRNA-like complexes between a 5" half tRNA(Arg) and a 3" half tRNA(Arg) with a 3" trailer, and can cleave the 3" half tRNA(Arg) after the discriminator nucleotide (Nashimoto M., 1996, RNA, 2:523-534).	Arginine	143-146	elaC ribonuclease Z 1	Homo sapiens	10-45
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Arginine	45-48	tachykinin precursor 1	Homo sapiens	32-43
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Arginine	45-48	tachykinin precursor 1	Homo sapiens	177-188
8981619-5	1997	In addition, L-arginine, a precursor for nitric oxide synthesis, was demonstrated to inhibit the ability of amylin to decrease food intake.	Arginine	13-23	islet amyloid polypeptide	Mus musculus	108-114
9437709-2	1997	The primary structure of python substance P (Arg-Pro-Arg-Pro-Gln-Gln-Phe-Tyr-Gly-Leu- Met-NH2) shows one amino acid substitution (Phe8--&gt;Tyr) compared with chicken/alligator substance P and an additional substitution (Lys3--&gt;Arg) as compared with mammalian substance P.	Arginine	45-48	tachykinin precursor 1	Homo sapiens	177-188
9044476-5	1997	This vasodilative effect of VIP was inhibited by 1 x 10(-6) M L-n omega-nitro-arginine, an endothelium-derived relaxing factor (nitric oxide) inhibitor, and was restored by the addition of 10(-4) M L-arginine, a substrate of nitric oxide.	Arginine	198-208	vasoactive intestinal peptide	Rattus norvegicus	28-31
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Arginine	133-136	kininogen 1	Homo sapiens	121-131
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Arginine	133-136	kininogen 1	Homo sapiens	263-273
8969188-0	1996	Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase.	Arginine	29-39	nitric oxide synthase 3	Homo sapiens	66-99
8969188-1	1996	Binding of L-arginine and imidazole to the endothelial nitric-oxide synthase (eNOS) was characterized by direct heme spectral perturbation.	Arginine	11-21	nitric oxide synthase 3	Homo sapiens	43-76
8969188-7	1996	Kd (L-arginine) is 0.5 microM and 2.0 microM, kon (L-arginine) is 2 x 10(5) M-1 s-1 and 8 x 10(5) M-1 s-1, koff (L-arginine) is 0.08 s-1 and 1.6 s-1 at 4 and 23 degrees C, respectively.	Arginine	4-14	myoregulin	Homo sapiens	76-89
8969188-7	1996	Kd (L-arginine) is 0.5 microM and 2.0 microM, kon (L-arginine) is 2 x 10(5) M-1 s-1 and 8 x 10(5) M-1 s-1, koff (L-arginine) is 0.08 s-1 and 1.6 s-1 at 4 and 23 degrees C, respectively.	Arginine	51-61	myoregulin	Homo sapiens	76-89
9014178-4	1996	The results showed that plasma arginine vasopressin (AVP) concentration increased after the injection of L-arginine (1.0 mg in microliters, i.c.v.)	Arginine	105-115	arginine vasopressin	Rattus norvegicus	40-51
9014178-4	1996	The results showed that plasma arginine vasopressin (AVP) concentration increased after the injection of L-arginine (1.0 mg in microliters, i.c.v.)	Arginine	105-115	arginine vasopressin	Rattus norvegicus	53-56
8969188-7	1996	Kd (L-arginine) is 0.5 microM and 2.0 microM, kon (L-arginine) is 2 x 10(5) M-1 s-1 and 8 x 10(5) M-1 s-1, koff (L-arginine) is 0.08 s-1 and 1.6 s-1 at 4 and 23 degrees C, respectively.	Arginine	51-61	myoregulin	Homo sapiens	76-89
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Arginine	125-128	integrin subunit beta 3	Homo sapiens	47-53
8985174-4	1996	PKBalpha phosphorylated histone H2B (Km 5 microM, Vmax 68 U/mg) specifically at Ser-36 which also lies in an Arg-Xaa-Arg-Xaa-Xaa-Ser-Hyd motif.	Arginine	109-112	AKT serine/threonine kinase 1	Homo sapiens	0-8
8985174-4	1996	PKBalpha phosphorylated histone H2B (Km 5 microM, Vmax 68 U/mg) specifically at Ser-36 which also lies in an Arg-Xaa-Arg-Xaa-Xaa-Ser-Hyd motif.	Arginine	117-120	AKT serine/threonine kinase 1	Homo sapiens	0-8
8985174-5	1996	The peptide Arg-Pro-Arg-Ala-Ala-Thr-Phe may be a relatively specific substrate for PKBalpha because, unlike other substrates, it is not phosphorylated by p70 S6 kinase or MAP kinase activated protein (MAPKAP) kinase-1.	Arginine	12-15	AKT serine/threonine kinase 1	Homo sapiens	83-91
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Arginine	125-128	integrin subunit beta 3	Homo sapiens	150-156
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Arginine	133-136	integrin subunit beta 3	Homo sapiens	47-53
8977249-8	1996	Using sequential overlapping peptides from the GPIIIa cytoplasmic region, an epitope for ITP-1 was localized to the sequence Arg-Ala-Arg-Ala-Lys-Trp (GPIIIa 734-739).	Arginine	133-136	integrin subunit beta 3	Homo sapiens	150-156
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	vasoactive intestinal peptide	Rattus norvegicus	81-84
8943276-4	1996	A growth hormone antagonist mutant Gly-120 --&gt; Arg, has been crystallized with its receptor as a 1:1 complex and the crystal structure determined at 2.9 A resolution.	Arginine	50-53	growth hormone 1	Homo sapiens	2-16
8954935-7	1996	On the basis of these observations, we conclude that hCG activates expression of iNOS mRNA in mouse peritoneal macrophages accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium.	Arginine	179-189	nitric oxide synthase 2, inducible	Mus musculus	81-85
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	vasoactive intestinal peptide	Rattus norvegicus	123-126
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	vasoactive intestinal peptide	Rattus norvegicus	123-126
8986225-6	1996	Three different mutations were found in the exon 3 sequence of CCKBR: His (CAT) at aa207--&gt;His (CAC) (5.4%), Arg (CGC) at aa215--&gt;His (CAC) (4.5%), and Val (GTG) at aa138--&gt;Met (ATG) (0.9%) in controls.	Arginine	112-115	cholecystokinin B receptor	Homo sapiens	63-68
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Arginine	180-190	nitric oxide synthase 2	Homo sapiens	4-25
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Arginine	180-190	heat shock protein family A (Hsp70) member 5	Homo sapiens	108-111
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Arginine	192-195	nitric oxide synthase 2	Homo sapiens	4-25
8962079-1	1996	The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (Cit) and nitric oxide (.NO).	Arginine	192-195	heat shock protein family A (Hsp70) member 5	Homo sapiens	108-111
8962079-8	1996	SOD lowered the NADPH:Cit stoichiometry to 0.8-1.1, suggesting either that additional reducing equivalents besides NADPH are required to explain Arg oxidation to .NO or that .NO was not primarily formed.	Arginine	145-148	superoxide dismutase 1	Homo sapiens	0-3
8940107-9	1996	Experiments using SWAP deletion mutants showed that splicing regulation of the fibronectin IIICS region and CD45 exon 4 requires a region including a carboxyl-terminal arginine/serine (R/S)-rich motif.	Arginine	168-176	fibronectin 1	Homo sapiens	79-90
8986639-1	1996	A new type of major aminopeptidase was purified from bovine brain by ammonium sulfate fractionation and TMAE-fractogel (anion exchange), arginine-Sepharose 4B, Sephadex G-150, and Sephadex G-100 column chromatography.	Arginine	137-145	carboxypeptidase Q	Homo sapiens	20-34
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Arginine	29-32	TNF receptor superfamily member 6b	Homo sapiens	4-7
8982501-11	1996	However, in the presence of NO synthase blockers and L-arginine (300 microM) together, charybdotoxin did significantly inhibit SIN-1-evoked relaxation to a similar extent as intact tissues (maximum response induced by around 80%; n = 4; P &lt; 0.01).	Arginine	53-63	MAPK associated protein 1	Homo sapiens	127-132
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Arginine	29-32	histatin 3	Homo sapiens	104-114
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Arginine	147-150	TNF receptor superfamily member 6b	Homo sapiens	4-7
8945538-5	1996	The m68 (Lys-13--&gt;Glu and Arg-22--&gt;Gly) variant is significantly less potent than the recombinant histatin-5 as well as m71, indicating that Arg-22 is crucial for the cidal activity.	Arginine	147-150	histatin 3	Homo sapiens	104-114
8945538-10	1996	Collectively, the data suggest that in addition to the helical conformation, specific residues such as Lys-13 and Arg-22 in the sequence of histatin-5 are, indeed, important for candidacidal activity.	Arginine	114-117	histatin 3	Homo sapiens	140-150
8958208-6	1996	We also tested the ability of IGFBP-2, a related binding protein which has an arginine-glycine-aspartate sequence but does not associate with integrin family members, to enhance IGF-I bioactivity.	Arginine	78-86	insulin-like growth factor-binding protein 2	Oryctolagus cuniculus	30-37
9018487-5	1996	Increased iNOS activity was demonstrated by conversion of arginine to citrulline.	Arginine	58-66	nitric oxide synthase 2, inducible	Mus musculus	10-14
8968849-1	1996	OBJECTIVE: The Trp64--&gt;Arg allele of the beta 3-adrenergic receptor gene was recently proposed to be associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), features of insulin resistance and a tendency to gain weight.	Arginine	26-29	insulin	Homo sapiens	144-151
8866564-7	1996	In women with normal glucose tolerance (n = 36), partial correlation studies controlling for body fat content revealed significant correlations between log plasma leptin and fasting insulin levels (r = 0.39, P = 0.029), the insulin response to arginine at both glucose levels (r = 0.38 and r = 0.37, P &lt; 0.036 for both), and the glucose potentiation of arginine-stimulated insulin secretion (r = 0.40, P = 0.025).	Arginine	244-252	insulin	Homo sapiens	224-231
8981210-0	1996	L-arginine prevents heart transplant arteriosclerosis by modulating the vascular cell proliferative response to insulin-like growth factor-I and interleukin-6.	Arginine	0-10	interleukin-6	Oryctolagus cuniculus	145-158
8981210-8	1996	The L-arginine significantly inhibits graft vascular cell proliferation induced by (1) insulin-like growth factor-I, from 328% +/- 66% to 154% +/- 28% (p &lt; 0.05), (2) interleukin-6, from 376% +/- 97% to 138% +/- 30% (p &lt; 0.05) and (3) the combination of insulin-like growth factor-I and interleukin-6 from 710% +/- 201% to 226% +/- 72% (p &lt; 0.05).	Arginine	4-14	interleukin-6	Oryctolagus cuniculus	170-183
8981210-8	1996	The L-arginine significantly inhibits graft vascular cell proliferation induced by (1) insulin-like growth factor-I, from 328% +/- 66% to 154% +/- 28% (p &lt; 0.05), (2) interleukin-6, from 376% +/- 97% to 138% +/- 30% (p &lt; 0.05) and (3) the combination of insulin-like growth factor-I and interleukin-6 from 710% +/- 201% to 226% +/- 72% (p &lt; 0.05).	Arginine	4-14	interleukin-6	Oryctolagus cuniculus	293-306
8981210-9	1996	In recipient native aorta explants L-arginine also abolishes vascular cell proliferation stimulated by insulin-like growth factor-I and interleukin-6.	Arginine	35-45	interleukin-6	Oryctolagus cuniculus	136-149
8911353-4	1996	RESULTS: The SLC3A1 gene has been shown to code for a protein that, when expressed in Xenopus oocytes, confers on these cells the ability to transport cystine, arginine, lysine and ornithine.	Arginine	160-168	solute carrier family 3 (amino acid transporter heavy chain), member 1 L homeolog	Xenopus laevis	13-19
8946838-5	1996	We previously reported that Tat is a direct angiogenic factor and noted the Tat arginine- and lysine-rich sequence is similar to that of other potent angiogenic growth factors, such as vascular endothelial growth factor-A (VEGF-A).	Arginine	80-88	vascular endothelial growth factor A	Homo sapiens	223-229
9121222-0	1996	Impairment of osteoblast growth by nitric oxide synthase inhibitors: an effect independent of nitric oxide and arginine transport inhibition.	Arginine	111-119	nitric oxide synthase 2	Homo sapiens	35-56
8940032-0	1996	In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --&gt; Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice.	Arginine	72-75	apolipoprotein E	Mus musculus	53-69
8940032-0	1996	In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --&gt; Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice.	Arginine	72-75	apolipoprotein E	Mus musculus	53-69
8940032-5	1996	5 mmol/liter), whereas the expression of the APOE*2(Arg-158 --&gt; Cys) gene in Apoe-/- mice minimally reduced serum cholesterol levels (APOE*2.Apoe-/-; 16.6 +/- 2.9 mmol/liter).	Arginine	52-55	apolipoprotein E	Mus musculus	45-49
8940032-5	1996	5 mmol/liter), whereas the expression of the APOE*2(Arg-158 --&gt; Cys) gene in Apoe-/- mice minimally reduced serum cholesterol levels (APOE*2.Apoe-/-; 16.6 +/- 2.9 mmol/liter).	Arginine	52-55	apolipoprotein E	Mus musculus	80-84
8939882-1	1996	A rat T-cell antigen RT6.1 catalyzes NAD glycohydrolysis but not ADP-ribose transfer, even though the antigen has significant amino acid identity with eucaryotic arginine-specific ADP-ribosyltransferases.	Arginine	162-170	ADP-ribosyltransferase 2b	Rattus norvegicus	21-24
8939882-8	1996	Thus, Glu-207 in rodent T-cell RT6 antigens is essential for transfer reaction of ADP-ribose to arginine.	Arginine	96-104	ADP-ribosyltransferase 2b	Rattus norvegicus	31-34
8960946-3	1996	It has been hypothesized an A/B (Gln 192--&gt;Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM).	Arginine	46-49	paraoxonase 1	Homo sapiens	67-70
8939759-3	1996	Most of the low molecular weight thrombin inhibitors studied so far are based on arginine and benzamidine.	Arginine	81-89	coagulation factor II, thrombin	Homo sapiens	33-41
8917638-0	1996	Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.	Arginine	71-79	coagulation factor II, thrombin	Homo sapiens	21-29
8939882-0	1996	Glutamic acid 207 in rodent T-cell RT6 antigens is essential for arginine-specific ADP-ribosylation.	Arginine	65-73	ADP-ribosyltransferase 2b	Rattus norvegicus	35-38
8950190-9	1996	However, the Lys-62--&gt;Arg substitution decreased translational accuracy and caused antibiotic sensitivity both in nonsuppressor and in SUP44 haploids.	Arginine	25-28	ribosomal 40S subunit protein S2	Saccharomyces cerevisiae S288C	138-143
8945918-11	1996	The inhibition of arginase activity that occurs by NOHA during marked iNOS induction may be a mechanism to ensure sufficient arginine availability for high-output production of NO.	Arginine	125-133	nitric oxide synthase 2	Rattus norvegicus	70-74
8922600-1	1996	A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination.	Arginine	25-28	fibronectin 1	Homo sapiens	103-114
8866564-7	1996	In women with normal glucose tolerance (n = 36), partial correlation studies controlling for body fat content revealed significant correlations between log plasma leptin and fasting insulin levels (r = 0.39, P = 0.029), the insulin response to arginine at both glucose levels (r = 0.38 and r = 0.37, P &lt; 0.036 for both), and the glucose potentiation of arginine-stimulated insulin secretion (r = 0.40, P = 0.025).	Arginine	244-252	insulin	Homo sapiens	224-231
8932993-11	1996	In women levels of cGMP rose and levels of L-arginine decreased significantly during insulin infusion, consistent with an increase in nitric oxide production.	Arginine	43-53	insulin	Homo sapiens	85-92
8911999-6	1996	After sequencing the entire exon 2, a new DRB1 allele was identified: DRB1*04var that is identical to DRB1*0404, except for one nucleotide at codon 88 resulting in a Ser--&gt;Arg exchange.	Arginine	175-178	major histocompatibility complex, class II, DR beta 1	Homo sapiens	42-46
8930408-2	1996	To assess the importance of three highly conserved amino acids, His7, Asp16, and His95, in determining the biological properties of mouse TIMP-1, they were mutated into Arg, Tyr, and Arg, respectively.	Arginine	169-172	tissue inhibitor of metalloproteinase 1	Mus musculus	138-144
8930408-2	1996	To assess the importance of three highly conserved amino acids, His7, Asp16, and His95, in determining the biological properties of mouse TIMP-1, they were mutated into Arg, Tyr, and Arg, respectively.	Arginine	183-186	tissue inhibitor of metalloproteinase 1	Mus musculus	138-144
8936471-0	1996	Hb Nunobiki or alpha 2 141 (HC3)Arg-->Cys beta 2 in a Belgian female results from a CGT-->TGT mutation in the alpha 2-globin gene.	Arginine	32-35	glycoprotein hormone subunit alpha 2	Homo sapiens	42-48
8960865-0	1996	Influence of the L-arginine-nitric oxide pathway on vasoactive intestinal polypeptide release and motility in the rat stomach in vitro.	Arginine	17-27	vasoactive intestinal peptide	Rattus norvegicus	52-85
8911999-6	1996	After sequencing the entire exon 2, a new DRB1 allele was identified: DRB1*04var that is identical to DRB1*0404, except for one nucleotide at codon 88 resulting in a Ser--&gt;Arg exchange.	Arginine	175-178	major histocompatibility complex, class II, DR beta 1	Homo sapiens	70-74
8911999-6	1996	After sequencing the entire exon 2, a new DRB1 allele was identified: DRB1*04var that is identical to DRB1*0404, except for one nucleotide at codon 88 resulting in a Ser--&gt;Arg exchange.	Arginine	175-178	major histocompatibility complex, class II, DR beta 1	Homo sapiens	70-74
8959637-8	1996	Pretreating the samples with arginine decreased or abolished immunofluorescence staining for PAI-1 and t-PA, but not for VN.	Arginine	29-37	plasminogen activator, tissue type	Homo sapiens	103-107
8938577-1	1996	Nitric oxide (NO), the free radical that accounts for the biological activity of endothelium-derived relaxing factor, is synthesized from L-arginine by NO synthase (NOS).	Arginine	138-148	nitric oxide synthase 2	Homo sapiens	152-163
8980155-3	1996	L-Arginine stimulated both GH and prolactin release under basal conditions but had no effect on the other hormones studied, while the nitric oxide donor molsidomine showed no effect on any hormone studied.	Arginine	0-10	growth hormone 1	Homo sapiens	27-29
8980155-5	1996	The current studies suggest that the effects of L-arginine on the stimulation of GH and prolactin release are unlikely to be mediated via the generation of nitric oxide.	Arginine	48-58	growth hormone 1	Homo sapiens	81-83
8980159-0	1996	Reproducibility of the growth hormone response to stimulation with growth hormone-releasing hormone plus arginine during lifespan.	Arginine	105-113	growth hormone 1	Homo sapiens	23-37
8980159-4	1996	We aimed to verify the between- and within-subject variability of the GH response to the GHRH + ARG test in normal subjects during their lifespan as well as in hypopituitaric patients with GH deficiency (GHD).	Arginine	96-99	growth hormone 1	Homo sapiens	70-72
8980159-8	1996	The GH responses to GHRH + ARG in C (1st vs 2nd session: 61.6 +/- 8.1 vs 66.5 +/- 9.4 microg/l), Y (70.4 +/- 10.1 vs 76.2 10.7 microg/l) and E (57.9 14.8 vs 52.1 +/- 8.0 microg/l) were similar and reproducible in all groups.	Arginine	27-30	growth hormone 1	Homo sapiens	4-6
8980159-10	1996	Similarly in GHD, the GH response to the GHRH + ARG test showed a good inter- (1st vs 2nd session: 2.3 +/- 0.5 vs 2.2 +/- 0.6 microg/l) and intra-individual reproducibility (r = 0.70, p &lt; 0.005).	Arginine	48-51	growth hormone 1	Homo sapiens	13-15
8980159-10	1996	Similarly in GHD, the GH response to the GHRH + ARG test showed a good inter- (1st vs 2nd session: 2.3 +/- 0.5 vs 2.2 +/- 0.6 microg/l) and intra-individual reproducibility (r = 0.70, p &lt; 0.005).	Arginine	48-51	growth hormone releasing hormone	Homo sapiens	41-45
8980159-11	1996	The GHRH + ARG-induced GH responses in GHD were markedly lower (p &lt; 0.0005) than those in age-matched controls and no overlap was found between GH peak responses in GHD and normal subjects.	Arginine	11-14	growth hormone 1	Homo sapiens	4-6
8980159-11	1996	The GHRH + ARG-induced GH responses in GHD were markedly lower (p &lt; 0.0005) than those in age-matched controls and no overlap was found between GH peak responses in GHD and normal subjects.	Arginine	11-14	growth hormone 1	Homo sapiens	23-25
8980159-12	1996	In normal subjects, the GH response to GHRH + ARG is very marked, independent of age and shows limited inter- and intra-individual variability.	Arginine	46-49	growth hormone 1	Homo sapiens	24-26
8980159-13	1996	The GH response to the GHRH + ARG test is strikingly reduced in panhypopituitaric patients with GHD, in whom the low somatotrope responsiveness is reproducible.	Arginine	30-33	growth hormone 1	Homo sapiens	4-6
8923846-1	1996	To determine potential abnormalities in beta-cell function after pancreas transplantation, the secretory capacity of the pancreatic grafts was assessed by measuring the glucose-potentiating effect on arginine-induced insulin secretion in recipients of cadaveric segmental (SPx; n = 8) and whole organ pancreas grafts (WPx; n = 6) and compared to that in nondiabetic kidney transplant recipients (Kx; n = 6) and normal controls (Ns; n = 7).	Arginine	200-208	insulin	Homo sapiens	217-224
8923846-3	1996	The secretory capacity of the beta-cell to arginine-induced (5 g L-arginine) insulin secretion was measured at fasting plasma glucose and 15 and 30 mmol/L glucose.	Arginine	43-51	insulin	Homo sapiens	77-84
8923846-3	1996	The secretory capacity of the beta-cell to arginine-induced (5 g L-arginine) insulin secretion was measured at fasting plasma glucose and 15 and 30 mmol/L glucose.	Arginine	65-75	insulin	Homo sapiens	77-84
8923846-6	1996	The prestimulation insulin secretion rate and maximal insulin secretion rate in response to hyperglycemia and arginine were significantly lower in SPx than in WPx, Kx, or Ns (P &lt; 0.05).	Arginine	110-118	insulin	Homo sapiens	54-61
8918602-4	1996	Of particular interest is the inhibitory effect of alpha 114Pro--&gt;Arg, which offers a novel opportunity to use an alpha-chain construct, in addition to a beta-chain construct in the same vector, in gene therapy for sickle cell anemia, with the objective of modifying a larger number of hemoglobin tetramers at a given level of expression.	Arginine	69-72	amyloid beta precursor protein	Homo sapiens	155-161
8988877-3	1996	NO generation is catalyzed by inducible nitric oxide synthase (iNOS) converting arginine into citrulline and NO.	Arginine	80-88	nitric oxide synthase 2	Homo sapiens	63-67
9004172-0	1996	GH secretion in Prader-Labhard-Willi syndrome: somatotrope responsiveness to GHRH is enhanced by arginine but not by pyridostigmine.	Arginine	97-105	growth hormone releasing hormone	Homo sapiens	77-81
9004172-2	1996	In normal subjects, GH response to GHRH is known to be greatly potentiated to the same extent by pyridostigmine (PD) or arginine (ARG) which probably act via inhibition of hypothalamic somatostatin release.	Arginine	120-128	growth hormone releasing hormone	Homo sapiens	35-39
9004172-2	1996	In normal subjects, GH response to GHRH is known to be greatly potentiated to the same extent by pyridostigmine (PD) or arginine (ARG) which probably act via inhibition of hypothalamic somatostatin release.	Arginine	130-133	growth hormone releasing hormone	Homo sapiens	35-39
9004172-6	1996	In NC, the GHRH-induced GH rise was potentiated to the same extent by PD or ARG.	Arginine	76-79	growth hormone releasing hormone	Homo sapiens	11-15
9004172-10	1996	In conclusion, our results demonstrate that in PLWS the low somatotrope responsiveness to GHRH is not enhanced by cholinergic potentiation while it is increased by arginine.	Arginine	164-172	growth hormone releasing hormone	Homo sapiens	90-94
8921841-10	1996	Re-Hst5 variants with either Glu or Lys/Arg substitutions demonstrated significantly lower candidacidal activity in both assays, while the variant with His mutated showed essentially no activity at physiological concentrations.	Arginine	40-43	histatin 3	Homo sapiens	3-7
8902155-0	1996	The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study.	Arginine	8-11	paraoxonase 1	Homo sapiens	34-45
8902155-0	1996	The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study.	Arginine	8-11	paraoxonase 1	Homo sapiens	47-50
8902155-2	1996	We studied the Gln/Arg polymorphism affecting codon 192 of human paraoxonase (PON 192) to determine whether this polymorphism, which is associated with serum paraoxonase (PON) activity, represents a risk factor for myocardial infarction (MI).	Arginine	19-22	paraoxonase 1	Homo sapiens	65-76
8902155-5	1996	The frequency of the PON 192/Arg allele in 405 MI patients who underwent coronary angiography was 0.295, 0.323 and 0.331, respectively in those with 1, 2 or 3 stenosed arteries (stenosis &gt; 50%) (ns).	Arginine	29-32	paraoxonase 1	Homo sapiens	21-24
8913515-0	1996	Stimulation of nitric oxide-cyclic GMP pathway by L-arginine increases the release of hepatic lipase from cultured rat hepatocytes.	Arginine	50-60	lipase C, hepatic type	Rattus norvegicus	86-100
8953650-1	1996	Based on the most recent available crystal structures and biochemical studies of protease complexes of normal and mutant serine protease inhibitors (serpins), we have built models of the complexes: alpha 1-antitrypsin + human neutrophil elastase; alpha 1-antitrypsin Pittsburgh (358Met--&gt;Arg) (Scott et al., J. Clin.	Arginine	291-294	coagulation factor II, thrombin	Homo sapiens	121-136
8953650-1	1996	Based on the most recent available crystal structures and biochemical studies of protease complexes of normal and mutant serine protease inhibitors (serpins), we have built models of the complexes: alpha 1-antitrypsin + human neutrophil elastase; alpha 1-antitrypsin Pittsburgh (358Met--&gt;Arg) (Scott et al., J. Clin.	Arginine	291-294	serpin family A member 1	Homo sapiens	198-217
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Arginine	135-138	tumor protein p53	Homo sapiens	101-104
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Arginine	155-158	tumor protein p53	Homo sapiens	101-104
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Arginine	155-158	tumor protein p53	Homo sapiens	101-104
8810317-1	1996	We have examined in detail the DNA binding properties of several immunopurified tumor-derived mutant p53 proteins (Val-143 --&gt; Ala, Arg-175 --&gt; His, Arg-248 --&gt; Trp, Arg-249 --&gt; Ser, and Arg-273 --&gt; His).	Arginine	155-158	tumor protein p53	Homo sapiens	101-104
8897874-6	1996	L-Arginine (10(-3) M, 246%) also caused a significant increase of VIP release that was antagonized by the NO synthase inhibitor N omega-nitro-L-arginine methyl ester (5 x 10(-4) M, 131%), which had no effect when given alone.	Arginine	0-10	vasoactive intestinal peptide	Rattus norvegicus	66-69
8839833-4	1996	Only one candidate mutation T(3445)--&gt;C in exon 26 was detected that predicts a replacement of cysteine (C) at position 386 of the mature vWF subunit by arginine (R).	Arginine	156-164	von Willebrand factor	Homo sapiens	141-144
8823359-11	1996	Treatment with L-arginine, on the other hand increased the production of interleukin-2 and interferon-gamma.	Arginine	15-25	interferon gamma	Mus musculus	91-107
8813154-5	1996	Overexpression of FN also suppressed the ability of the tumor cells to proliferate in soft agar, whereas the suppression was reversed by inclusion in soft agar of the Arg-Gly-Asp (RGD)-containing peptide and adhesion-blocking antibodies against the central cell-binding domain of FN.	Arginine	167-170	fibronectin 1	Homo sapiens	18-20
8915981-7	1996	Treatment of animals with UUO with L-arginine significantly blunted the increase in all parameters except for transforming growth factor-beta 1 mRNA expression.	Arginine	35-45	transforming growth factor, beta 1	Rattus norvegicus	110-143
8936961-0	1996	Insulin and glucagon responses to provocation with glucose and arginine in prepubertal children with thalassemia major before and after long-term blood transfusion.	Arginine	63-71	insulin	Homo sapiens	0-7
8936961-6	1996	Thirty minutes after starting arginine infusion, serum insulin concentration was significantly lower in thalassemic children compared to before therapy.	Arginine	30-38	insulin	Homo sapiens	55-62
8936961-7	1996	Basal and arginine-stimulated glucagon secretions were significantly elevated in thalassemic children on long-term blood transfusion with significantly low serum insulin/glucagon ratios.	Arginine	10-18	insulin	Homo sapiens	162-169
8843188-2	1996	Apo B-43.7, found in a daughter and her father, was due to a C --> T change in base position 6162 of the apo B gene converting the arginine (residue 1986) codon CGA to a stop codon TGA.	Arginine	131-139	apolipoprotein B	Homo sapiens	0-5
8862424-8	1996	We observe that, in addition to the membrane targeting signal and the conserved arg-arg residues within the core region, mutations in the proline-rich domain of Nef also affect its ability to associate with the serine kinase activity.	Arginine	46-49	S100 calcium binding protein B	Homo sapiens	161-164
8843188-2	1996	Apo B-43.7, found in a daughter and her father, was due to a C --> T change in base position 6162 of the apo B gene converting the arginine (residue 1986) codon CGA to a stop codon TGA.	Arginine	131-139	apolipoprotein B	Homo sapiens	105-110
8910896-0	1996	A nonsense mutation (Arg-196-Term) in exon 6 of the human TP53 gene identified in small cell lung carcinoma.	Arginine	21-24	tumor protein p53	Homo sapiens	58-62
8897608-2	1996	Previous work from other laboratories established that a predominant feature of endogenous peptides eluted from purified B27 is an arginine at position 2.	Arginine	131-139	melanocortin 2 receptor accessory protein	Homo sapiens	121-124
8903118-9	1996	Insulin and glucagon responses to arginine and glucose were similar before and after NA in subgroups with initially low and high insulin responses to glucose.	Arginine	34-42	insulin	Homo sapiens	0-7
8862424-8	1996	We observe that, in addition to the membrane targeting signal and the conserved arg-arg residues within the core region, mutations in the proline-rich domain of Nef also affect its ability to associate with the serine kinase activity.	Arginine	80-83	S100 calcium binding protein B	Homo sapiens	161-164
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	28-31	S100 calcium binding protein B	Homo sapiens	48-51
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	28-31	S100 calcium binding protein B	Homo sapiens	81-84
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	28-31	CD4 molecule	Homo sapiens	107-110
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	32-35	S100 calcium binding protein B	Homo sapiens	48-51
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	32-35	S100 calcium binding protein B	Homo sapiens	81-84
8862424-9	1996	The region encompassing the arg-arg residues of Nef is shown to be important for Nef-mediated cell-surface CD4 down-modulation as well as enhancement of viral growth properties.	Arginine	32-35	CD4 molecule	Homo sapiens	107-110
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Arginine	200-203	S100 calcium binding protein B	Homo sapiens	50-53
8798637-8	1996	Although astroglial iNOS Km approximately 10 microM L-arginine for intracellular substrate, hyperbolic kinetics of inducible iNOS activity measured as a function of extracellular L-arginine concentration gave Km approximately 50 microM L-arginine with intact cells.	Arginine	179-189	nitric oxide synthase 2	Rattus norvegicus	125-129
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Arginine	200-203	S100 calcium binding protein B	Homo sapiens	219-222
8798637-8	1996	Although astroglial iNOS Km approximately 10 microM L-arginine for intracellular substrate, hyperbolic kinetics of inducible iNOS activity measured as a function of extracellular L-arginine concentration gave Km approximately 50 microM L-arginine with intact cells.	Arginine	179-189	nitric oxide synthase 2	Rattus norvegicus	125-129
8798637-11	1996	These findings expand the current understanding of NO biosynthesis modulation and implicate a coordinated regulation of intracellular iNOS enzyme activity with membrane L-arginine transport in brain.	Arginine	169-179	nitric oxide synthase 2	Rattus norvegicus	134-138
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Arginine	204-207	S100 calcium binding protein B	Homo sapiens	50-53
8862424-13	1996	These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain.	Arginine	204-207	S100 calcium binding protein B	Homo sapiens	219-222
8831761-1	1996	Naphthalenic lignan lactone 3a (L-702,539), a potent and selective 5-lipoxygenase (5-LO) inhibitor, is extensively metabolized at two different sites: the tetrahydropyran and the lactone rings.	Arginine	32-34	arachidonate 5-lipoxygenase	Homo sapiens	67-81
8798661-2	1996	We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mechanism.	Arginine	55-58	protein kinase C alpha	Homo sapiens	145-148
8798661-2	1996	We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mechanism.	Arginine	63-66	protein kinase C alpha	Homo sapiens	145-148
8798661-2	1996	We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mechanism.	Arginine	63-66	protein kinase C alpha	Homo sapiens	145-148
8798661-2	1996	We recently reported that the peptide substrate analog Arg-Lys-Arg-Cys-Leu-Arg-Arg-Leu (RKRCLRRL) irreversibly inactivates the protein kinase C (PKC) isozymes alpha, beta, and gamma in a dithiothreitol-sensitive manner by an active site-directed mechanism.	Arginine	63-66	protein kinase C alpha	Homo sapiens	145-148
8809083-0	1996	Functional and structural role of arginine 103 in human erythropoietin.	Arginine	34-42	erythropoietin	Homo sapiens	56-70
8809083-11	1996	In contrast, Arg103His and Arg103Lys had specific activities equal to 2 and 25%, respectively, of that of wild-type erythropoietin, indicating that a positive charge may be required at position 103 but that other constraints necessitate the presence of Arg for full activity.	Arginine	13-16	erythropoietin	Homo sapiens	116-130
8899736-0	1996	Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency.	Arginine	0-8	ornithine transcarbamylase	Mus musculus	79-105
8899736-1	1996	The sparse-fur (spf) mouse, with an X-linked hepatic ornithine transcarbamylase (OTC, E.C.2.1.3.3) deficiency, exhibits significantly lower levels of arginine in the brain as compared to normal controls.	Arginine	150-158	ornithine transcarbamylase	Mus musculus	53-79
8899736-1	1996	The sparse-fur (spf) mouse, with an X-linked hepatic ornithine transcarbamylase (OTC, E.C.2.1.3.3) deficiency, exhibits significantly lower levels of arginine in the brain as compared to normal controls.	Arginine	150-158	ornithine transcarbamylase	Mus musculus	81-84
8889032-0	1996	Role of endogenous angiotensin II in renal hemodynamic and excretory responses to L-arginine infusion.	Arginine	82-92	angiotensinogen	Rattus norvegicus	19-33
8790354-6	1996	We propose that one site, containing residues Arg-150 and Lys-152, binds initially to EPO receptor on the cell surface.	Arginine	46-49	erythropoietin	Homo sapiens	86-89
8889032-1	1996	The purpose of this study was to investigate whether endogenous angiotensin II has a functional role in renal hemodynamic and excretory changes induced by L-arginine, a substrate for nitric oxide (NO), in anesthetized rats.	Arginine	155-165	angiotensinogen	Rattus norvegicus	64-78
8887060-0	1996	Comparative study on the effect of signal peptide codons and arginine codons on the expression of human interferon-alpha 1 gene in Escherichia coli.	Arginine	61-69	interferon alpha 1	Homo sapiens	104-122
8824527-12	1996	At this passage, mutation of the p53 gene was detected at codon 273 of exon 8, with G to T conversion (Arg to Leu).	Arginine	103-106	tumor protein p53	Homo sapiens	33-36
8877295-5	1996	arginine at all three glucose levels and the slopeAIR, i.e. the glucose potentiation of insulin secretion, were markedly increased in the women with the lowest insulin sensitivity and NGT compared to those with medium or high insulin sensitivity.	Arginine	0-8	insulin	Homo sapiens	88-95
8877295-5	1996	arginine at all three glucose levels and the slopeAIR, i.e. the glucose potentiation of insulin secretion, were markedly increased in the women with the lowest insulin sensitivity and NGT compared to those with medium or high insulin sensitivity.	Arginine	0-8	insulin	Homo sapiens	160-167
8888925-7	1996	At the first evaluation, 5.6 +/- 0.4 years after irradiation, the GH peak values after arginine-insulin stimulation correlated with the age at irradiation (p &lt; 0.03), taking into account the time since irradiation.	Arginine	87-95	growth hormone 1	Homo sapiens	66-68
8887060-1	1996	Human interferon-alpha 1 (HuIFN-alpha 1) gene containing signal peptide codons is poorly expressed in bacteria, and this is explained by the presence of clusters of rare (AGG) arginine codons in its structure.	Arginine	176-184	interferon alpha 1	Homo sapiens	6-24
8905849-1	1996	A large family affected with autosomal dominant retinitis pigmentosa (ADRP) with a sectorial phenotype showed a previously described (G to A) mutation in the rhodopsin gene resulting in the substitution of a glycine residue by an arginine in codon 106 of rhodopsin.	Arginine	230-238	rhodopsin	Homo sapiens	158-167
8885249-6	1996	Western analysis showed that the Lys40--&gt;Arg mutant expressed at a level comparable to that of wild type receptor and, like wild type, exhibited a predominant immunoreactive mature form of LH/CG-R.	Arginine	44-47	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	192-199
8905849-1	1996	A large family affected with autosomal dominant retinitis pigmentosa (ADRP) with a sectorial phenotype showed a previously described (G to A) mutation in the rhodopsin gene resulting in the substitution of a glycine residue by an arginine in codon 106 of rhodopsin.	Arginine	230-238	rhodopsin	Homo sapiens	255-264
8702576-10	1996	Only substitution of glutamic acid 255 altered the preference of apoE4 from VLDL to HDL, indicating that this was the sole residue in the carboxyl terminus that interacts with arginine 61.	Arginine	176-184	apolipoprotein E	Homo sapiens	65-70
8903029-1	1996	NADPH diaphorase histochemistry is commonly used to identify cells containing nitric oxide synthase (NOS), the enzyme catalyzing the production of nitric oxide from L-arginine.	Arginine	165-175	nitric oxide synthase 2	Homo sapiens	78-99
8702665-8	1996	In three-dimensional structures of G protein heterotrimers, Arg-231 is located in a region, switch 2, that is thought to interact with the betagamma subunit rather than with the hormone receptor.	Arginine	60-63	nuclear receptor subfamily 4 group A member 1	Homo sapiens	178-194
8753809-1	1996	Inducible-Nitric oxide synthase (iNOS, EC 1.14.13.39) catalyzes the formation of nitric oxide (NO) and L-citrulline from L-Arg.	Arginine	121-126	nitric oxide synthase 2	Homo sapiens	0-31
8753809-1	1996	Inducible-Nitric oxide synthase (iNOS, EC 1.14.13.39) catalyzes the formation of nitric oxide (NO) and L-citrulline from L-Arg.	Arginine	121-126	nitric oxide synthase 2	Homo sapiens	33-37
8753809-3	1996	The natural product, (-)-noformycin was found to be a potent, competitive inhibitor of recombinant human iNOS with respect to L-Arg with a Ki = 1.3 +/- 0.3 microM.	Arginine	126-131	nitric oxide synthase 2	Homo sapiens	105-109
8702576-15	1996	These studies establish that interaction of arginine 61 and glutamic acid 255 mediates apoE4 domain interaction.	Arginine	44-52	apolipoprotein E	Homo sapiens	87-92
8704215-4	1996	The underlying mutation was Arg to stop at codon 150 (CGA--&gt;TGA) and was designated R150X, which defined allele Lyon of the EPB3 gene.	Arginine	28-31	chromogranin A	Homo sapiens	54-57
8679946-1	1996	Conformationally and configurationally restricted rotameric probes of phenylalanine have been incorporated in the sequence of substance P (SP)-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2-for analyzing the binding pockets of Phe7 (S7) and Phe8 (S8), in the neurokinin-1 receptor.	Arginine	143-146	tachykinin precursor 1	Homo sapiens	126-137
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	interleukin 1 beta	Rattus norvegicus	135-153
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	interferon gamma	Homo sapiens	248-275
8759097-8	1996	Furthermore, peptide RPPGF or high-molecular-weight kininogen prevented alpha-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine.	Arginine	154-162	coagulation factor II, thrombin	Homo sapiens	78-86
8759097-8	1996	Furthermore, peptide RPPGF or high-molecular-weight kininogen prevented alpha-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine.	Arginine	154-162	coagulation factor II, thrombin	Homo sapiens	105-113
8759097-9	1996	CONCLUSIONS: These results indicate that bradykinin and its metabolites are selective antithrombins by preventing alpha-thrombin cleavage of the cloned thrombin receptor between arginine-41 and serine-42.	Arginine	178-186	kininogen 1	Homo sapiens	41-51
8759097-9	1996	CONCLUSIONS: These results indicate that bradykinin and its metabolites are selective antithrombins by preventing alpha-thrombin cleavage of the cloned thrombin receptor between arginine-41 and serine-42.	Arginine	178-186	coagulation factor II, thrombin	Homo sapiens	90-98
8894440-5	1996	Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis.	Arginine	257-265	interleukin 1 beta	Rattus norvegicus	99-108
8894440-5	1996	Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis.	Arginine	325-333	interleukin 1 beta	Rattus norvegicus	99-108
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	interleukin 1 beta	Rattus norvegicus	155-164
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	interleukin 1 beta	Homo sapiens	193-202
8894440-2	1996	Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma).	Arginine	27-35	tumor necrosis factor	Homo sapiens	235-244
8707380-2	1996	Inhibition of nitric oxide synthase by L-arginine analogues such as N omega-nitro-L-arginine methyl ester (L-NAME) in spontaneously hypertensive rats (SHR) is associated with malignant hypertension and enhanced expression of the endothelin-1 gene in some blood vessels.	Arginine	39-49	endothelin 1	Rattus norvegicus	229-241
8810734-0	1996	Effects of glucose load and/or arginine on insulin and growth hormone secretion in hyperprolactinemia and obesity.	Arginine	31-39	growth hormone 1	Homo sapiens	55-69
8810734-7	1996	The arginine-induced insulin release in HP and OB was similar (4219.4 +/- 631.7 and 4107.3 +/- 643.2 mU x min x l(-1), respectively), both being higher (p &lt; 0.02) than in NS (2178.1 +/- 290.9 mU x min x l(-1).	Arginine	4-12	insulin	Homo sapiens	21-28
8810734-8	1996	Glucose and arginine had an additive effect on insulin release in HP and NS (19,769.1 +/- 3249.6 and 10,996.6 +/- 1201.0 mU x min 1(-1), respectively) and a synergistic effect in OB (28 117.3 +/- 5224.7 mU x min x l(-1)).	Arginine	12-20	insulin	Homo sapiens	47-54
8810734-9	1996	In HP the insulin response to the combined administration of glucose and arginine was not significantly different from the one in OB, and both were higher (p &lt; 0.05) than in NS.	Arginine	73-81	insulin	Homo sapiens	10-17
8810734-13	1996	The arginine-induced GH secretion was inhibited by glucose in HP and NS but not in OB.	Arginine	4-12	growth hormone 1	Homo sapiens	21-23
8810734-15	1996	The insulin hyperresponsiveness in hyperprolactinemia is more clearly demonstrated by combined stimulation with glucose and arginine.	Arginine	124-132	insulin	Homo sapiens	4-11
8858209-2	1996	NO is produced by the enzyme nitric oxide synthase (NOS), in a reaction where arginine is the main substrate.	Arginine	78-86	nitric oxide synthase 2	Homo sapiens	29-50
8889808-0	1996	Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analyses.	Arginine	46-49	carbonyl reductase 2	Mus musculus	63-86
8756328-4	1996	The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA.	Arginine	4-13	cyclin A2	Homo sapiens	116-123
8756331-4	1996	The X-ray crystal structure of apoE2 Ala 154 demonstrated that Arg 150 was relocated within the receptor binding region.	Arginine	63-66	apolipoprotein E	Homo sapiens	31-36
16525512-5	1996	For bradykinin and its analogues differing by modification of the residues between the two arginine groups on either end of the molecule, the singly and doubly protonated ions have average activation energies of 1.2 and 0.8 eV, respectively, and average A values of 10(8) and 10(12) s(-1), respectively, i.e., the presence of a second charge reduces the activation energy by 0.4 eV and decreases the A value by a factor of 10(4).	Arginine	91-99	kininogen 1	Homo sapiens	4-14
8690107-14	1996	Normalization in older women of the reduced GH response to GH-RH by arginine supports this hypothesis.	Arginine	68-76	growth hormone releasing hormone	Homo sapiens	59-64
9275467-7	1996	Although the ischemic kidney was capable of expressing iNOS mRNA in the presence of L-arginine after ischemia, the production of NO in the old may not be regulated at the transcriptional level, other factors such as NOS enzyme activity, availability of L-arginine and O2, metabolism of NO after its production were suspected to be involved.	Arginine	84-94	nitric oxide synthase 2	Rattus norvegicus	55-59
8703980-2	1996	The derivatives are Ac-Glu[N(C18H37)2]-(Sar-Sar-Pro)n-Arg-Arg-Pro-Tyr-Ile-Leu-OH (D3nNT, n = 0,1,2,3), where a dioctadecyl group was connected to the N-terminal side of neurotensin 8-13 fragment directly or through a hydrophilic and flexible spacer chain of different lengths.	Arginine	54-57	neurotensin	Homo sapiens	169-180
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	154-157	angiotensin-converting enzyme	Cricetulus griseus	43-46
8663272-1	1996	Through the use of oligonucleotide-directed mutagenesis we have generated variants of a recombinant human parathyroid (PTH) hormone-(1-34)-homoserine (RPTH) in which a positively charged residue (Arg or Lys), a negatively charged residue (Glu), or a neutral residue (Gly) has been substituted at every position throughout the peptide.	Arginine	196-199	parathyroid hormone	Homo sapiens	119-122
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	154-157	angiotensin-converting enzyme	Cricetulus griseus	43-46
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	154-157	angiotensin-converting enzyme	Cricetulus griseus	43-46
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	190-193	angiotensin-converting enzyme	Cricetulus griseus	43-46
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	190-193	angiotensin-converting enzyme	Cricetulus griseus	43-46
8755736-6	1996	Observed masses of 4264 (WT-ACE) and 4269 (ACE-JM delta 17) are in good agreement with an expected mass of 4262 for the C-terminal CNBr peptide ending at Arg-627, indicating cleavage at the Arg-627/Ser-628 bond in both WT-ACE and ACE-JM delta 17, at distances of 24 and 10 residues from the membrane, respectively.	Arginine	190-193	angiotensin-converting enzyme	Cricetulus griseus	43-46
8755736-7	1996	Data for ACE-JM delta 24 are also consistent with cleavage at or near Arg-627.	Arginine	70-73	angiotensin-converting enzyme	Cricetulus griseus	9-12
8755736-14	1996	On the basis of these and other data, we propose that the CHO cell MPSP that solubilizes ACE (1) only cleaves proteins embedded in a membrane; (2) requires an accessible stalk and cleaves at a minimum distance from both the membrane and proximal extracellular domain; (3) positions itself primarily with respect to the proximal extracellular domain; and (4) may have a weak preference for cleavage at Arg/Lys-X bonds.	Arginine	401-404	angiotensin-converting enzyme	Cricetulus griseus	89-92
8755738-3	1996	Steady-state kinetic studies on recombinant human inducible nitric oxide synthase (rH-iNOS) demonstrate that imidazole and 1-phenylimidazole are competitive and reversible inhibitors versus L-arginine.	Arginine	190-200	nitric oxide synthase 2	Homo sapiens	86-90
8755738-10	1996	These data taken together suggest that the L-arginine, dioxygen, and the BH4 binding sites are in close proximity in rH-iNOS.	Arginine	43-53	nitric oxide synthase 2	Homo sapiens	120-124
8832057-13	1996	The IL-1 beta-induced reduction in SNP-stimulated cyclic GMP accumulation in cultured cells was dependent on NO production, as arginine depletion abolished the downregulation of cyclic GMP accumulation in response to SNP.	Arginine	127-135	interleukin 1 beta	Rattus norvegicus	4-13
8924627-1	1996	The topography of the binding site of a monoclonal anti-substance P antibody directed toward the C-terminal pentapeptide of substance P, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, was analyzed further using a wide range of constrained analogues of substance P.	Arginine	137-140	tachykinin precursor 1	Homo sapiens	56-67
8812639-3	1996	NO results from the oxidative deimination of l-arginine to l-citrulline by NO synthase (NOS), several isoforms of which have recently been isolated.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	75-86
8812645-0	1996	Expression and Detection of Inducible Nitric Oxide Synthase in Experimental Models of Inflammation Three different isoforms of the enzyme nitric oxide synthase (NOS) (EC 1.14.13.39) catalyze the formation of nitric oxide (NO) from l-arginine, which is then converted to l-citrulline.	Arginine	231-241	nitric oxide synthase 2	Homo sapiens	38-59
8812645-0	1996	Expression and Detection of Inducible Nitric Oxide Synthase in Experimental Models of Inflammation Three different isoforms of the enzyme nitric oxide synthase (NOS) (EC 1.14.13.39) catalyze the formation of nitric oxide (NO) from l-arginine, which is then converted to l-citrulline.	Arginine	231-241	nitric oxide synthase 2	Homo sapiens	138-159
8832069-2	1996	The L-arginine derivatives NG-nitro-L-arginine (L-NOARG) and NG-nitro-L-arginine methyl ester (L-NAME) have been widely used to inhibit constitutive NO synthase (NOS) in different biological systems.	Arginine	4-14	nitric oxide synthase 2	Homo sapiens	149-160
8818956-2	1996	The variant is a guanine to adenine base change at position 1019 of the ovine CFTR cDNA, corresponding to an arginine (R) to glutamine (Q) amino acid substitution at position 297 in the predicted CFTR polypeptide.	Arginine	109-117	CF transmembrane conductance regulator	Homo sapiens	78-82
8647919-1	1996	That L-arginine (L-Arg) augments the host response to acute bacterial sepsis suggests that this amino acid intervenes early in the immune response, perhaps via the nitric oxide synthetase (NOS) pathway.	Arginine	5-15	nitric oxide synthase 2	Homo sapiens	164-187
8647919-1	1996	That L-arginine (L-Arg) augments the host response to acute bacterial sepsis suggests that this amino acid intervenes early in the immune response, perhaps via the nitric oxide synthetase (NOS) pathway.	Arginine	17-22	nitric oxide synthase 2	Homo sapiens	164-187
8818341-14	1996	L-Arginine, 30 mumol, reversed the effect of L-NAME, 1 mumol, on the bradykinin- and histamine-induced albumin extravasation into the nasal airway.	Arginine	0-10	kininogen 1	Homo sapiens	69-79
8818956-2	1996	The variant is a guanine to adenine base change at position 1019 of the ovine CFTR cDNA, corresponding to an arginine (R) to glutamine (Q) amino acid substitution at position 297 in the predicted CFTR polypeptide.	Arginine	109-117	CF transmembrane conductance regulator	Homo sapiens	196-200
8663132-4	1996	Direct sequence analysis of the polymerase chain reaction-amplified p21 gene revealed a C to T transition in codon 94 that caused the substitution of a tryptophan for an arginine in a tumor specimen.	Arginine	170-178	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-71
8663002-1	1996	Fibronectin has been shown to bind to integrin alphaIIbbeta3 in Arg-Gly-Asp (RGD)-dependent and -independent manners.	Arginine	64-67	fibronectin 1	Homo sapiens	0-11
8663132-8	1996	On the basis of these functional analysis, we propose that the Arg residue at position 94 is important for the CDK inhibitory role of p21.	Arginine	63-66	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-137
8662966-9	1996	The inhibitory effect of apoE was not abolished by reductive methylation of lysine residues, whereas selective modification of arginine residues by 1,2-cyclohexadione completely cancelled the inhibitory effect of apoE.	Arginine	127-135	apolipoprotein E	Rattus norvegicus	213-217
8662966-10	1996	It is concluded that apoE can specifically inhibit the LPL-mediated hydrolysis of emulsion triglycerides both in vitro and in vivo, and that arginine residues in apoE are essential for this effect.	Arginine	141-149	apolipoprotein E	Rattus norvegicus	21-25
8662966-10	1996	It is concluded that apoE can specifically inhibit the LPL-mediated hydrolysis of emulsion triglycerides both in vitro and in vivo, and that arginine residues in apoE are essential for this effect.	Arginine	141-149	lipoprotein lipase	Rattus norvegicus	55-58
8662966-10	1996	It is concluded that apoE can specifically inhibit the LPL-mediated hydrolysis of emulsion triglycerides both in vitro and in vivo, and that arginine residues in apoE are essential for this effect.	Arginine	141-149	apolipoprotein E	Rattus norvegicus	162-166
8672462-0	1996	Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometry.	Arginine	126-134	nitric oxide synthase 2	Homo sapiens	67-98
8672462-2	1996	The binding of ligands to the iNOS arginine site perturbs the environment of the high-spin ferriheme in a highly ligand-specific manner.	Arginine	35-43	nitric oxide synthase 2	Homo sapiens	30-34
8672462-3	1996	The iNOS forms five-coordinate, high-spin complexes with arginine analogs which are clearly related to the corresponding complexes of nNOS.	Arginine	57-65	nitric oxide synthase 2	Homo sapiens	4-8
8649776-2	1996	By using recombination PCR in vitro mutagenesis, we introduced point mutations into the codon 273 of wild-type (wt) p53 (pC53-SN3) from Arg to His (pC53-273H [273H]), Asp (273D), Pro (273P), Lys (273K), Leu (273L) or Thr (273T), and compared their biological and biochemical activities with wt p53 and cancer-derived 175H, 248W and 273H/309S.	Arginine	136-139	tumor protein p53	Homo sapiens	116-119
8664327-0	1996	Characterization of a novel variant of apolipoprotein E, E2 Fukuoka (Arg-224 --&gt; Gln) in a hyperlipidemic patient with xanthomatosis.	Arginine	69-72	apolipoprotein E	Homo sapiens	39-55
8664327-5	1996	Sequence analysis of the patient"s DNA, which was amplified by PCR and subcloned, revealed a single substitution from arginine (CGG) to glutamine (CAG) at residue 224, thereby adding one negatively charged unit to apo E3.	Arginine	118-126	apolipoprotein E	Homo sapiens	214-220
8764145-4	1996	We observed that cNOS activity could be quantitated in islet homogenates by monitoring the formation of L-citrulline from L-arginine using an Amprep CBA cation-exhange minicolumn before derivatization with o-phthaldialdehyde and subsequent high-performance liquid chromatography analysis.	Arginine	122-132	nitric oxide synthase 3	Homo sapiens	17-21
8764214-3	1996	Nitric oxide synthase inhibitor (nitro-L-arginine methyl ester) caused a significant inhibition of bradykinin-induced glycoconjugate secretion, which was reversed by the addition of L-arginine.	Arginine	39-49	kininogen 1	Homo sapiens	99-109
8679526-18	1996	Two arginine side chains, Arg-52 in the P6(5) structure and Arg-44 in molecule A of the P6(1) structure, are turned away drastically from the ligand (p-aminobenzoyl)glutamic acid moiety as compared with previously reported DHFR binary complex structures.	Arginine	4-12	dihydrofolate reductase	Escherichia coli	223-227
8679526-18	1996	Two arginine side chains, Arg-52 in the P6(5) structure and Arg-44 in molecule A of the P6(1) structure, are turned away drastically from the ligand (p-aminobenzoyl)glutamic acid moiety as compared with previously reported DHFR binary complex structures.	Arginine	26-29	dihydrofolate reductase	Escherichia coli	223-227
8679526-18	1996	Two arginine side chains, Arg-52 in the P6(5) structure and Arg-44 in molecule A of the P6(1) structure, are turned away drastically from the ligand (p-aminobenzoyl)glutamic acid moiety as compared with previously reported DHFR binary complex structures.	Arginine	60-63	dihydrofolate reductase	Escherichia coli	223-227
8764214-2	1996	Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it.	Arginine	162-165	kininogen 1	Homo sapiens	0-10
8764214-2	1996	Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it.	Arginine	162-165	kininogen 1	Homo sapiens	189-199
8764214-2	1996	Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it.	Arginine	162-165	bradykinin receptor B1	Homo sapiens	254-277
8842499-4	1996	On the other hand, endothelial cells can contribute to host anti-metastatic responses, e.g. by production of the cytotoxic molecule nitric oxide (NO) from arginine with the help of the inducible nitric oxide synthase (iNOS).	Arginine	155-163	nitric oxide synthase 2, inducible	Mus musculus	185-216
24178685-6	1996	Treatment of SMCs with 100nM Ang II significantly inhibited the Na(+)-dependent arginine transport without affecting systems y(+), A, and L. This effect occurred in a dose-dependent manner (IC50 of 8.9 +- 0.9nM) and is mediated by the AT-1 receptor subtype because it was blocked by DUP 753, a non-peptide antagonist of this receptor.	Arginine	80-88	angiotensinogen	Homo sapiens	29-35
24178685-11	1996	These findings suggest that although Ang II inhibits concomitantly arginine transport and NO synthesis in SMCs, the reduction of NO synthesis is not associated with alterations in the cellular transport of arginine.	Arginine	67-75	angiotensinogen	Homo sapiens	37-43
8653684-3	1996	The mutation results in an insertion of Arg at codon 105, which interrupts the last of the four ankyrin repeats of the p16 protein, motifs which have been demonstrated as important in binding and inhibiting the activity of cyclin D-dependent kinases 4 and 6 in cell cycle G1 phase regulation.	Arginine	40-43	cyclin dependent kinase inhibitor 2A	Homo sapiens	119-122
8842499-4	1996	On the other hand, endothelial cells can contribute to host anti-metastatic responses, e.g. by production of the cytotoxic molecule nitric oxide (NO) from arginine with the help of the inducible nitric oxide synthase (iNOS).	Arginine	155-163	nitric oxide synthase 2, inducible	Mus musculus	218-222
8889361-1	1996	Argatroban is an arginine derivative that is a highly specific thrombin inhibitor.	Arginine	17-25	coagulation factor II, thrombin	Homo sapiens	63-71
8743501-3	1996	NOS catalyzes the NADPH- and oxygen-dependent oxygenation of L-arginine to NO plus L-citrulline in a reaction that requires at least six cofactors including NADPH, FAD, FMN, tetrahydrobiopterin, heme, and calmodulin.	Arginine	61-71	calmodulin 1	Homo sapiens	205-215
8635651-4	1996	In another set of experiments carried out to investigate the effects of L-arginine, insulin induced a dose-dependent cGMP increase, from 23.6 +/- 6.9 to 59.0 +/- 12.0 pmol/10(9) platelets (P = 0.0001); with L-arginine, basal cGMP values increased to 35.5 +/- 6.6 pmol/10(9) platelets (P = 0.05), and insulin maintained its ability to enhance dose-dependently cGMP values, which rose to 76.8 +/- 19.4 pmol/10(9) platelets (P = 0.003).	Arginine	72-82	insulin	Homo sapiens	84-91
8635651-4	1996	In another set of experiments carried out to investigate the effects of L-arginine, insulin induced a dose-dependent cGMP increase, from 23.6 +/- 6.9 to 59.0 +/- 12.0 pmol/10(9) platelets (P = 0.0001); with L-arginine, basal cGMP values increased to 35.5 +/- 6.6 pmol/10(9) platelets (P = 0.05), and insulin maintained its ability to enhance dose-dependently cGMP values, which rose to 76.8 +/- 19.4 pmol/10(9) platelets (P = 0.003).	Arginine	207-217	insulin	Homo sapiens	84-91
8766942-4	1996	A single nucleotide mutation in the tumors carrying the gsp oncogene was observed, which replaced an arginine (CGT) in the normal protein with cysteine (TGT) in eight tumors and serine (AGT) in one tumor.	Arginine	101-109	GNAS complex locus	Homo sapiens	56-59
8804927-2	1996	Endogenous NO is generated from L-arginine by the action of several types of NO synthase (NOS).	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	77-88
8648715-7	1996	The characteristics of the molecular surface of BTV and AHSV VP7 suggest why AHSV VP7 is much less soluble than BTV VP7 and indicate the possibility of attachment to the cell via attachment of an Arg-Gly-Asp (RGD) motif in the top domain of VP7 to a cellular integrin for both of these orbiviruses.	Arginine	196-199	VP7	Bluetongue virus	61-64
8648715-7	1996	The characteristics of the molecular surface of BTV and AHSV VP7 suggest why AHSV VP7 is much less soluble than BTV VP7 and indicate the possibility of attachment to the cell via attachment of an Arg-Gly-Asp (RGD) motif in the top domain of VP7 to a cellular integrin for both of these orbiviruses.	Arginine	196-199	VP7	Bluetongue virus	82-85
8648715-7	1996	The characteristics of the molecular surface of BTV and AHSV VP7 suggest why AHSV VP7 is much less soluble than BTV VP7 and indicate the possibility of attachment to the cell via attachment of an Arg-Gly-Asp (RGD) motif in the top domain of VP7 to a cellular integrin for both of these orbiviruses.	Arginine	196-199	VP7	Bluetongue virus	82-85
8648715-7	1996	The characteristics of the molecular surface of BTV and AHSV VP7 suggest why AHSV VP7 is much less soluble than BTV VP7 and indicate the possibility of attachment to the cell via attachment of an Arg-Gly-Asp (RGD) motif in the top domain of VP7 to a cellular integrin for both of these orbiviruses.	Arginine	196-199	VP7	Bluetongue virus	82-85
8662729-2	1996	We have identified mutations at two polar sites in the TM regions of the rat parathyroid hormone (PTH)/PTH-related peptide receptor, Arg-233 in TM 2 and Gln-451 in TM 7, that caused 17-200-fold reductions in the binding affinity of the agonist peptide PTH-(1-34) without affecting the binding affinity of the antagonist/partial agonist PTH-(3-34).	Arginine	133-136	parathyroid hormone	Rattus norvegicus	77-96
8718682-1	1996	Mammalian tRNA 3" processing endoribonuclease (3" tRNase) can be converted to an RNA cutter that recognizes four bases, with about a 65-nt 3"-truncated tRNA(Arg) or tRNA(Ala).	Arginine	157-160	elaC ribonuclease Z 1	Homo sapiens	10-45
8793891-8	1996	ARG clearly increased the GH response to GHRH in the controls, whereas it was unable to further potentiate the GH-releasing effect of GHRH in runners, thus suggesting that the increased GH responsiveness to GHRH might be due to an exercise-related decrease in endogenous hypothalamic somatostatinergic activity.	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	41-45
8662674-5	1996	Following a 24-h exposure to IL-1beta and IFNgamma, arginine uptake increases Vmax = 167 pmol/2 X 10(5) cells/min) and a second low-affinity L-arginine transporter activity appears (Km = 1.2 mM).	Arginine	52-60	interleukin 1 beta	Rattus norvegicus	29-37
8767448-0	1996	Detection of the apolipoprotein B-100 arg(3500) &gt; gl mutation in familial defective apoB-100 by temperature-gradient gel electrophoresis.	Arginine	38-41	apolipoprotein B	Homo sapiens	17-37
8767448-0	1996	Detection of the apolipoprotein B-100 arg(3500) &gt; gl mutation in familial defective apoB-100 by temperature-gradient gel electrophoresis.	Arginine	38-41	apolipoprotein B	Homo sapiens	87-95
8767485-10	1996	The Arg/Lys sequence at position 25-30, which resembles the binding site of apoE, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor efficiently.	Arginine	4-7	apolipoprotein E	Rattus norvegicus	76-80
9388995-0	1996	[Effects of L-arginine on acute hypoxic pulmonary hypertension and production of endothelin-1 in vivo and in cultured endothelial cells].	Arginine	12-22	endothelin 1	Canis lupus familiaris	81-93
8662674-10	1996	Thus, NO production by cardiac myocytes exposed to IL-1beta plus IFNgamma appears to be dependent on the coinduction of CAT-1, CAT-2A, and CAT-2B, while insulin independently augments L-arginine transport through CAT- 1.	Arginine	184-194	interleukin 1 beta	Rattus norvegicus	51-59
8626679-4	1996	Interleukin-1 beta and tumor necrosis factor-alpha, alone or in combination, stimulated both the uptake of L-arginine and the accumulation of nitrite in the culture media in a dose-dependent manner.	Arginine	107-117	interleukin 1 beta	Rattus norvegicus	0-50
8616809-7	1996	Two of five PDC cases and one papillary carcinoma revealed point mutations in exon 8 as follows; GTG (val) to CTG (leu) at codon 272 in case 23T, CGA (arg) to CCA (pro) at codon 306 in case of 30T, and CGG (arg) to AGG (arg) at codon 282 in case 28T.	Arginine	151-154	chromogranin A	Homo sapiens	146-149
8616812-3	1996	This study demonstrates that argininosuccinate synthetase and GTP-cyclohydrolase-I, which catalyze rate-limiting steps in the synthesis of iNOS substrate (arginine) and cofactor (tetrahydrobiopterin), respectively, are coinduced with iNOS expression in two human tumor cell lines.	Arginine	155-163	nitric oxide synthase 2	Homo sapiens	139-143
8616812-3	1996	This study demonstrates that argininosuccinate synthetase and GTP-cyclohydrolase-I, which catalyze rate-limiting steps in the synthesis of iNOS substrate (arginine) and cofactor (tetrahydrobiopterin), respectively, are coinduced with iNOS expression in two human tumor cell lines.	Arginine	155-163	nitric oxide synthase 2	Homo sapiens	234-238
8626679-6	1996	Ang II in the presence of cytokines up-regulated L-arginine transport while inhibiting nitrite accumulation.	Arginine	49-59	angiotensinogen	Rattus norvegicus	0-6
8626679-11	1996	Furthermore, Ang II and cytokine stimulation of L-arginine uptake involves the differential regulation of the cationic amino acid transporter (cat) genes.	Arginine	48-58	angiotensinogen	Rattus norvegicus	13-19
8639550-1	1996	Inducible nitric oxide synthase (iNOS) catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L-arginine and O2.	Arginine	120-130	nitric oxide synthase 2	Homo sapiens	0-31
8621259-7	1996	Lastly, we suggest that one possible mechanism involved in IL-2-induced PMN cytotoxicity against the B6 clone occurs via the nitric oxide pathway, which could be inhibited upon addition of the arginine analog, N(G)-monomethyl-L-arginine.	Arginine	193-201	interleukin 2	Homo sapiens	59-63
8631896-5	1996	The NER efficacy of TFIIH is greatly diminished or abolished upon substitution of Rad3 with the rad3 Arg-48 mutant protein or Rad25 with the rad25 Arg-392 mutant protein, respectively, thus indicating a role of the Rad3 and Rad25 DNA helicase functions in the incision of damaged DNA.	Arginine	147-150	TFIIH/NER complex ATPase/helicase subunit SSL2	Saccharomyces cerevisiae S288C	141-146
8639550-1	1996	Inducible nitric oxide synthase (iNOS) catalyzes the NADPH-dependent formation of nitric oxide (NO) and citrulline from L-arginine and O2.	Arginine	120-130	nitric oxide synthase 2	Homo sapiens	33-37
8639550-2	1996	In addition to serving as substrate, L-arginine alters the enzyme"s heme iron spin equilibrium, increases its NADPH oxidation, and promotes assembly of active dimeric iNOS from inactive monomers.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	167-171
8639550-3	1996	To understand what structural aspects of L-arginine are important for causing these effects, we have studied the interactions of iNOS with several L-arginine and guanidine analogs.	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	129-133
8639550-3	1996	To understand what structural aspects of L-arginine are important for causing these effects, we have studied the interactions of iNOS with several L-arginine and guanidine analogs.	Arginine	147-157	nitric oxide synthase 2	Homo sapiens	129-133
8639550-11	1996	These latter affects are mediated through binding of the guanidinium portion of L-arginine and its analogs to a single site within iNOS and are relatively independent of the amino acid portion of the molecule.	Arginine	80-90	nitric oxide synthase 2	Homo sapiens	131-135
8783012-5	1996	The six major spots corresponded to the Arg and des-Arg forms of SAA1 alpha and SAA2 alpha, respectively, and to the glycosylated and nonglycosylated form of constitutive serum amyloid A protein (C-SAA).	Arginine	40-43	serum amyloid A1	Homo sapiens	65-69
8612536-0	1996	L-arginine/nitric oxide amplifies the magnitude and duration of the luteinizing hormone surge induced by estrogen: involvement of neuropeptide Y.	Arginine	0-10	neuropeptide Y	Rattus norvegicus	130-144
8612536-11	1996	Antisense, not missense, NPY oligos blocked the L-Arg-induced potentiation of the LH surge.	Arginine	48-53	neuropeptide Y	Rattus norvegicus	25-28
8783012-5	1996	The six major spots corresponded to the Arg and des-Arg forms of SAA1 alpha and SAA2 alpha, respectively, and to the glycosylated and nonglycosylated form of constitutive serum amyloid A protein (C-SAA).	Arginine	52-55	serum amyloid A1	Homo sapiens	65-69
8735649-8	1996	The nitric oxide (NO) synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME; 30 microM) augmented constrictor responses to NA, EFS, methoxamine and vasopressin in all groups, and as shown for EFS and NA, this was reversed by L-arginine (300 microM).	Arginine	51-61	arginine vasopressin	Rattus norvegicus	155-166
9162298-3	1996	A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population.	Arginine	110-118	tumor protein p53	Homo sapiens	27-30
9162298-3	1996	A germline polymorphism of p53 with a single-base change at codon 72 that causes an amino acid replacement of arginine (Arg; CGC) by proline (PRO; CCC) has also been reported to be associated with cancer susceptibility in a Japanese population.	Arginine	120-123	tumor protein p53	Homo sapiens	27-30
9162298-8	1996	The study of the p53 polymorphism in the healthy population showed allele frequencies of 0.79 (Arg) and 0.21 (Pro).	Arginine	95-98	tumor protein p53	Homo sapiens	17-20
8631683-1	1996	lambda"s int gene contains an unusually high frequency of the rare arginine codons AGA and AGG, as well as dual rare Arg codons at three positions.	Arginine	117-120	int	Escherichia virus Lambda	9-12
8631683-6	1996	This indicates that depletion of the rare Arg tRNA due to ribosome stalling at multiple AGA and AGG codons on the overexpressed int mRNA underlies all of these phenomena.	Arginine	42-45	int	Escherichia virus Lambda	128-131
8626871-2	1996	Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin.	Arginine	0-8	growth hormone 1	Homo sapiens	26-28
8626871-12	1996	The lower GH response to GHRH-Arg stimulation after a previous GHRH bolus suggests, furthermore, that the readily available GH pool in the human pituitary may be limited.	Arginine	30-33	growth hormone 1	Homo sapiens	10-12
8819013-3	1996	These mutations result in an Arg--&gt;Trp amino acid substitution at residue 249 and an Ile--&gt;Phe amino acid substitution at residue 255 in a highly conserved region in the DNA-binding core domain of the p53 protein.	Arginine	29-32	tumor protein p53	Homo sapiens	207-210
8732685-6	1996	Mutation of a highly conserved arginine in the second intracellular loop of the rLHR (designated rLHR-R442H) also does not affect hCG binding but impairs signal transduction.	Arginine	31-39	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	80-84
8732685-6	1996	Mutation of a highly conserved arginine in the second intracellular loop of the rLHR (designated rLHR-R442H) also does not affect hCG binding but impairs signal transduction.	Arginine	31-39	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	97-101
8626871-2	1996	Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin.	Arginine	0-3	growth hormone 1	Homo sapiens	26-28
8626871-10	1996	We could show that decreasing GH responses to repeated GHRH can be avoided by a combined stimulation with GHRH/Arg.	Arginine	111-114	growth hormone 1	Homo sapiens	30-32
8616720-1	1996	Inducible nitric oxide synthase (iNOS) is a transcriptionally regulated enzyme that synthesizes nitric oxide from L-arginine that has a key role in the pathophysiology of systemic inflammation and sepsis.	Arginine	114-124	nitric oxide synthase 2	Rattus norvegicus	0-31
8616720-1	1996	Inducible nitric oxide synthase (iNOS) is a transcriptionally regulated enzyme that synthesizes nitric oxide from L-arginine that has a key role in the pathophysiology of systemic inflammation and sepsis.	Arginine	114-124	nitric oxide synthase 2	Rattus norvegicus	33-37
8626871-10	1996	We could show that decreasing GH responses to repeated GHRH can be avoided by a combined stimulation with GHRH/Arg.	Arginine	111-114	growth hormone releasing hormone	Homo sapiens	55-59
8626871-11	1996	These findings suggest that the decreased GH response to a second GHRH bolus may be partly due to an elevated hypothalamic somatostatin secretion, which can be suppressed by Arg.	Arginine	174-177	growth hormone 1	Homo sapiens	42-44
8626871-11	1996	These findings suggest that the decreased GH response to a second GHRH bolus may be partly due to an elevated hypothalamic somatostatin secretion, which can be suppressed by Arg.	Arginine	174-177	growth hormone releasing hormone	Homo sapiens	66-70
8626871-12	1996	The lower GH response to GHRH-Arg stimulation after a previous GHRH bolus suggests, furthermore, that the readily available GH pool in the human pituitary may be limited.	Arginine	30-33	growth hormone releasing hormone	Homo sapiens	25-29
8626871-12	1996	The lower GH response to GHRH-Arg stimulation after a previous GHRH bolus suggests, furthermore, that the readily available GH pool in the human pituitary may be limited.	Arginine	30-33	growth hormone releasing hormone	Homo sapiens	63-67
8626871-12	1996	The lower GH response to GHRH-Arg stimulation after a previous GHRH bolus suggests, furthermore, that the readily available GH pool in the human pituitary may be limited.	Arginine	30-33	growth hormone 1	Homo sapiens	25-27
8732754-12	1996	In trypsin, the substitution of Ile 174-Arg 175 by Gly 174-Gln 175 makes the S3 aryl site more polar because the Arg 175 side chain is directed away from thrombin and into the solvent, whereas Gln 175 is not.	Arginine	40-43	coagulation factor II, thrombin	Homo sapiens	154-162
8613982-8	1996	The S1 pocket of t-PA is almost identical to that of trypsin, whereas the S2 site is considerably reduced in size by the imposing Tyr368 side-chain, in agreement with the measured preference for P1 Arg and P2 Gly residues.	Arginine	198-201	plasminogen activator, tissue type	Homo sapiens	17-21
8860437-3	1996	Aminopeptidase activity in vaginal homogenates, as well as in tissue pieces, was determined using 4-methoxy-2-naphthylamides of leucine, alanine, arginine, and glutamic acid as specific substrates.	Arginine	146-154	carboxypeptidase Q	Homo sapiens	0-14
8633068-3	1996	Site-directed mutagenesis of IRP1 and IRP2 reveals that, although the binding affinities for consensus IREs are indistinguishable, the contributions of arginine residues in the active-site cleft to the binding affinity are different in the two RNA binding sites.	Arginine	152-160	iron responsive element binding protein 2	Homo sapiens	38-42
8622978-0	1996	Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.	Arginine	72-75	von Willebrand factor	Homo sapiens	26-47
8723046-5	1996	Blunted growth hormone (GH) secretion was shown in response to insulin-induced hypoglycemia, arginine infusion, and GH-releasing hormone (GHRH) loading test, and in 24 h spontaneous GH profile.	Arginine	93-101	growth hormone 1	Homo sapiens	8-22
8619498-8	1996	The hydrolysis of VIP at Arg-14 was slightly affected by the presence of the dansyl group at the N-terminus.	Arginine	25-28	vasoactive intestinal peptide	Homo sapiens	18-21
8621763-3	1996	Sequence analysis of the proband band 3 cDNA and genomic DNA showed a C --&gt; T substitution resulting in a nonsense mutation (CGA --&gt; TGA; Arg --&gt; Stop) at the position corresponding to codon 646 in human red cell band 3 cDNA.	Arginine	144-147	chromogranin A	Homo sapiens	128-131
8626534-0	1996	A nuclear envelope-associated kinase phosphorylates arginine-serine motifs and modulates interactions between the lamin B receptor and other nuclear proteins.	Arginine	52-60	lamin B receptor	Homo sapiens	114-130
8636380-5	1996	Direct sequencing of the proinsulin gene exon 3 showed a heterozygous point mutation (CGT--&gt;CAT) resulting in the substitution of Arg--&gt;His in position 65 (corresponding to the AC cleavage site) in the index case, his mother, and his maternal grandmother.	Arginine	133-136	insulin	Homo sapiens	25-35
8928785-6	1996	We conclude that in this model of the human intestinal epithelium 1) cytokine-mediated induction of iNOS is Ca2+ independent, weakly steroid sensitive, and may involve the activation of nuclear factor-kappa B and a tyrosine kinase, and 2) iNOS activity is Ca2+ -independent and inhibited by hypoxia, NG-substituted L-arginine analogues, and isothioureas.	Arginine	315-325	nitric oxide synthase 2	Homo sapiens	100-104
9132167-1	1996	It has been shown that human growth hormone (hGH) is attacked and digested at Arg(134)-Thr(135) by thrombin and plasmin, facilitating its further degradation in the plasma and tissues.	Arginine	78-81	coagulation factor II, thrombin	Homo sapiens	99-107
8862501-0	1996	Effect of bromocriptine on insulin, growth hormone and prolactin responses to arginine in obesity.	Arginine	78-86	prolactin	Homo sapiens	55-64
9132160-3	1996	In the present study the effect of thrombin and collagen on L-arginine transport in human platelets was investigated.	Arginine	60-70	coagulation factor II, thrombin	Homo sapiens	35-43
9132160-4	1996	Thrombin significantly affected L-arginine uptake whereas collagen was uneffective.	Arginine	32-42	coagulation factor II, thrombin	Homo sapiens	0-8
9132160-5	1996	In particular, thrombin increased Vmax of the uptake by 77%, while it reduced the affinity of the carrier for L-arginine.	Arginine	110-120	coagulation factor II, thrombin	Homo sapiens	15-23
9132167-1	1996	It has been shown that human growth hormone (hGH) is attacked and digested at Arg(134)-Thr(135) by thrombin and plasmin, facilitating its further degradation in the plasma and tissues.	Arginine	78-81	growth hormone 1	Homo sapiens	29-43
8862501-11	1996	Our data also show that the low GH response to arginine in obesity is not improved by the coadministration of bromocriptine, in agreement with the hypothesis that both substances act by the same mechanism, i.e. inhibition of endogenous somatostatin release.	Arginine	47-55	growth hormone 1	Homo sapiens	32-34
8631749-5	1996	The heterodimer catalyzed NADPH-dependent NO synthesis from L-arginine at a rate of 52 +/- 6 nmol of NO/min/nmol of heme, which is half the rate of purified iNOS homodimer.	Arginine	60-70	nitric oxide synthase 2	Homo sapiens	157-161
8730589-2	1996	Patch-clamp methods have been used to examine single-channel properties of recombinant GluR5 and GluR6 kainate-preferring glutamate receptors which differ in a single amino acid residue as a result of RNA editing at the Q/R (glutamine/arginine) site.	Arginine	235-243	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	87-92
8609839-5	1996	Insulin secretion was studied after intravenous arginine (5 g) at fasting, and at blood glucose levels of 14 and greater than 25 mmol/L.	Arginine	48-56	insulin	Homo sapiens	0-7
8609839-7	1996	Obese subjects with normal glucose tolerance had a higher insulin response to both glucose (P &lt; or = .004) and arginine (P &lt; or = .02) than nonobese women, and higher glucose potentiation of insulin secretion, slopeAIR (P = .05).	Arginine	114-122	insulin	Homo sapiens	58-65
8830326-1	1996	A variant human epidermal growth factor (EGF) receptor (HER) with a transition (G to A) at codon 497, resulting in a substitution of a lysine for an arginine, was recently demonstrated in several human pancreatic cancer cell lines.	Arginine	149-157	epidermal growth factor receptor	Homo sapiens	16-54
8739887-2	1996	injection of neuropeptide Y (NPY) on basal and glucose- or arginine-stimulated insulinemia was studied in anesthetized and conscious rats.	Arginine	59-67	neuropeptide Y	Rattus norvegicus	13-27
8739887-2	1996	injection of neuropeptide Y (NPY) on basal and glucose- or arginine-stimulated insulinemia was studied in anesthetized and conscious rats.	Arginine	59-67	neuropeptide Y	Rattus norvegicus	29-32
8705874-0	1996	Three novel and one C31133T (Arg-338--&gt;Stop) mutations of antihemophilic factor IX gene detected in Taiwan.	Arginine	29-32	coagulation factor IX	Homo sapiens	76-85
8636149-2	1996	Two naturally occurring mutant insulin receptors, Arg-1174 --&gt; Gln and Leu-1178 --&gt; Pro, found in patients with dominantly inherited Type A insulin resistance, showed unusual signaling properties when stably expressed in Chinese hamster ovary (CHO) cells.	Arginine	50-53	insulin	Homo sapiens	31-38
8636149-7	1996	In contrast, CHO cells expressing an insulin receptor mutated at the ATP binding site (Lys-1030 --&gt; Arg) showed no insulin-stimulated autophosphorylation or phosphorylation of IRS-1.	Arginine	103-106	insulin	Cricetulus griseus	37-44
8839053-1	1996	The Ca(2+)-dependent binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) stimulates the catalytic oxidation of L-arginine to nitric oxide.	Arginine	128-138	calmodulin 1	Homo sapiens	32-42
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	Arginine	49-59	interleukin 1 beta	Homo sapiens	131-141
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	Arginine	49-59	interleukin 6	Homo sapiens	146-150
8845178-3	1996	Inhibition of the nitric oxide production by the L-arginine analogue N(G)-monomethyl-L-arginine (NMMA), resulted in an increase of IL-1(beta) and IL-6, whereas the TNF-alpha concentrations remained unchanged, suggesting specific inhibitory effects of nitric oxide on the LPS-stimulated cytokine production by alveolar macrophages.	Arginine	49-59	tumor necrosis factor	Homo sapiens	164-173
8621396-2	1996	Because dimerization of purified iNOS subunits requires tetrahydrobiopterin, heme, and L-arginine, we investigated if availability of these factors also influences intracellular assembly of dimeric iNOS.	Arginine	87-97	nitric oxide synthase 2, inducible	Mus musculus	33-37
8839053-1	1996	The Ca(2+)-dependent binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) stimulates the catalytic oxidation of L-arginine to nitric oxide.	Arginine	128-138	calmodulin 1	Homo sapiens	44-47
8839053-7	1996	Incubation of nNOS with suboptimal concentrations of arginine results in sulfoxidation of the CaM methionine residues.	Arginine	53-61	calmodulin 1	Homo sapiens	94-97
8698438-4	1996	Furthermore, addition of Ng-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, at 10(-3) mol/L significantly blocked the suppressive effect of parathyroid hormone-related protein (1-34) on endothelin-1 secretion, and further addition of 5x10(-3) mol/L L-arginine significantly attenuated the blocking effect of N(G)-monomethyl-L-arginine.	Arginine	39-49	endothelin 1	Homo sapiens	200-212
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	59-67	growth hormone 1	Homo sapiens	95-109
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	59-67	growth hormone 1	Homo sapiens	111-113
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	59-67	growth hormone releasing hormone	Homo sapiens	127-159
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	59-67	growth hormone releasing hormone	Homo sapiens	161-165
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	69-72	growth hormone 1	Homo sapiens	95-109
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	69-72	growth hormone 1	Homo sapiens	111-113
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	69-72	growth hormone releasing hormone	Homo sapiens	127-159
8616534-1	1996	Pyridostigmine (PD), a muscarinic cholinergic agonist, and arginine (ARG) clearly increase the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) in man.	Arginine	69-72	growth hormone releasing hormone	Homo sapiens	161-165
8648190-7	1996	Adhesion to fibronectin and vitronectin was found to be divalent cation- and arginine-glycine-aspartic acid-dependent, and could be blocked by antibodies to beta 1 or alpha 5, and alpha v or alpha v beta 5, respectively.	Arginine	77-85	fibronectin 1	Homo sapiens	12-23
8642287-0	1996	Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy.	Arginine	0-8	major histocompatibility complex, class II, DR beta 1	Homo sapiens	49-57
8606636-7	1996	The persistence of a substantial response to arginine, ie, higher than the fifth control percentile, even at a late stage, was confirmed in five of nine diabetic patients tested either at onset of the disease or during non-insulin-receiving remission.	Arginine	45-53	insulin	Homo sapiens	223-230
8728322-5	1996	In addition, the encoded mature N-terminal sequence was changed from Cys- to Arg-Glu-Phe- to link the CETP sequence to the yeast acid phosphatase signal peptide.	Arginine	77-80	cholesteryl ester transfer protein	Oryctolagus cuniculus	102-106
8882464-5	1996	Since 1990, numerous studies which exclusively employed L-arginine analogues as specific NO synthase (NOS) inhibitors, have been undertaken to examine the role of NO in the regulation of the cerebral circulation.	Arginine	56-66	nitric oxide synthase 2	Homo sapiens	89-100
8637223-2	1996	Phorbol myristate acetate (PMA)-stimulated HL60 cells had no effect on LCL and a decreased rate of cytochrome C reduction in the presence of increasing concentrations of L-arginine.	Arginine	170-180	cytochrome c, somatic	Homo sapiens	99-111
8637223-3	1996	Inhibition of L-arginine-mediated cytochrome C reduction was relieved by L-N(G)-monomethyl arginine (L-NMMA), an inhibitor of nitric oxide synthesis, in a concentration-dependent manner.	Arginine	14-24	cytochrome c, somatic	Homo sapiens	34-46
8637223-4	1996	In contrast, DMSO-differentiated cells and human neutrophils separated from blood showed decreased rates of LCL and cytochrome C reduction with increasing concentrations Of L-arginine, which were relieved to some extent by L-NMMA in a dose-dependent manner.	Arginine	173-183	cytochrome c, somatic	Homo sapiens	116-128
8637223-6	1996	Possible inhibition of NADPH oxidase has been suggested to explain the responses of LCL, cytochrome C reduction and nitrate production by nitric oxide in the presence of L-arginine.	Arginine	170-180	cytochrome c, somatic	Homo sapiens	89-101
8577707-7	1996	After membrane insertion, TNF exhibits a trimeric configuration in which the carboxyl termini are no longer exposed; however, the proximal salt-bridged Lys-11 residues as well as regional surface amino acids (Glu-23, Arg-32, and Arg-44) are notably more accessible to proteases.	Arginine	217-220	tumor necrosis factor	Homo sapiens	26-29
8594204-7	1996	Solution experiments with wild-type ArgR and oligomerization domain indicate that the hexameric form is greatly stabilized upon arginine binding.	Arginine	128-136	arginine repressor	Escherichia coli	36-40
8594204-8	1996	The crystal structures and solution experiments together suggest possible mechanisms of how arginine activates ArgR to bind to its DNA targets and provides a stereochemical basis for interpreting the results of mutagenesis and biochemical experiments with ArgR.	Arginine	92-100	arginine repressor	Escherichia coli	111-115
8594204-8	1996	The crystal structures and solution experiments together suggest possible mechanisms of how arginine activates ArgR to bind to its DNA targets and provides a stereochemical basis for interpreting the results of mutagenesis and biochemical experiments with ArgR.	Arginine	92-100	arginine repressor	Escherichia coli	256-260
8613546-8	1996	The GH responses to arginine (30 g i.v.	Arginine	20-28	growth hormone 1	Homo sapiens	4-6
8594204-0	1996	Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli.	Arginine	37-47	arginine repressor	Escherichia coli	70-88
8594204-1	1996	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form.	Arginine	41-51	arginine repressor	Escherichia coli	91-109
8594204-1	1996	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form.	Arginine	41-51	arginine repressor	Escherichia coli	111-115
8594204-1	1996	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form.	Arginine	43-51	arginine repressor	Escherichia coli	91-109
8594204-1	1996	The structure of the oligomerization and L-arginine binding domain of the Escherichia coli arginine repressor (ArgR) has been determined using X-ray diffraction methods at 2.2 A resolution with bound arginine and at 2.8 A in the unliganded form.	Arginine	43-51	arginine repressor	Escherichia coli	111-115
8667664-5	1996	Direct DNA sequencing revealed a CGC to CTG change in codon 135, that substitutes arginine for leucine residue in rhodopsin.	Arginine	82-90	rhodopsin	Homo sapiens	114-123
8576237-11	1996	As iNOS, AS, and AL were coinduced in rat tissues and cells, citrulline-arginine recycling seems to be important in NO synthesis under the conditions of stimulation.	Arginine	72-80	nitric oxide synthase 2	Rattus norvegicus	3-7
8577707-7	1996	After membrane insertion, TNF exhibits a trimeric configuration in which the carboxyl termini are no longer exposed; however, the proximal salt-bridged Lys-11 residues as well as regional surface amino acids (Glu-23, Arg-32, and Arg-44) are notably more accessible to proteases.	Arginine	229-232	tumor necrosis factor	Homo sapiens	26-29
8625447-1	1996	The p53 tumor suppressor gene is often mutated in various human cancers and a common polymorphism is known at codon 72 of exon 4, with two alleles encoding either arginine (CGC) or proline (CCC).	Arginine	163-171	tumor protein p53	Homo sapiens	4-7
8867898-4	1996	Expression in Escherichia coli led to secretion in the periplasmic space of a fully bioactive hPRL variant constituting authentic hPRL with a peptide tag, i.e. Ala-Ser-(His)6-Ile-Glu-Gly-Arg, at its N-terminal.	Arginine	187-190	prolactin	Homo sapiens	94-98
8589252-1	1996	Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states.	Arginine	200-203	angiotensinogen	Homo sapiens	163-177
8589252-1	1996	Conformational free energy calculations using an empirical potential ECEPP/3 (Empirical Conformational Energy Program for Peptides, Version 3) were carried out on angiotensin II (AII) of sequence Asp-Arg-Val-Tyr-Ile-His-Pro-Phe to find the stable conformations of the free state in the unhydrated and the hydrated states.	Arginine	200-203	angiotensinogen	Homo sapiens	179-182
16843989-0	1996	Nitric oxide-independent inhibitory effects of L-arginine analog NG-monomethy-L-arginine on the generation of interleukin-2 activated cytotoxic activity in humans.	Arginine	47-57	interleukin 2	Homo sapiens	110-123
8646406-3	1996	Unlike most L-arginine based inhibitors, however, some guanidines and S-alkylisothioureas, in particular aminoethylisothiourea (AETU), show selectivity towards the inducible isoform (iNOS) over the constitutive isoforms (endothelial, ecNOS and brain isoform, bNOS) and so may be of therapeutic benefit.	Arginine	12-22	nitric oxide synthase 2	Rattus norvegicus	183-187
8549863-6	1996	Used alone or in combination, TNF and IFN significantly enhanced the activity of inducible nitric oxide synthase as determined by measuring the conversion of 14C-labeled arginine to 14C-labeled citrulline and nitric oxide.	Arginine	170-178	tumor necrosis factor	Rattus norvegicus	30-33
8646406-16	1996	In contrast to their potent effects on iNOS, some AATUs and MAGs were 20-100 times weaker than NG-methyl-L-arginine and NG-nitro-L-arginine as inhibitors of ecNOS as assessed by their effects on the conversion of L-arginine to L-citrulline in homogenates of bovine endothelial cells and by their pressor effects in anaesthetized rats.	Arginine	105-115	nitric oxide synthase 3	Bos taurus	157-162
8549863-7	1996	Use of arginine-free medium, without or with NG-monomethyl-L-arginine, resulted in inhibition of nitrite formation by 5-1,000 U/ml IFN+TNF and partial restoration of the insulin secretory response to glucose.	Arginine	7-15	tumor necrosis factor	Rattus norvegicus	131-138
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Arginine	75-78	fibronectin 1	Homo sapiens	50-61
8630528-6	1996	This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta.	Arginine	265-275	interleukin 1 beta	Rattus norvegicus	115-133
8630528-6	1996	This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta.	Arginine	265-275	interleukin 1 beta	Rattus norvegicus	115-133
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Arginine	75-78	fibronectin 1	Homo sapiens	63-65
8598655-2	1996	The purpose of this study was to determine if the inflammatory mediators, endotoxin (LPS) and interferon gamma (IFN), stimulate arginine transport and nitric oxide production in a murine breast cancer cell line.	Arginine	128-136	interferon gamma	Mus musculus	94-116
8624806-3	1996	Analysis of natural peptides bound to RT1.Aa by both pool sequencing and anhydrotrypsin chromatography revealed that TAP polymorphism determined the presence or absence of arginine as the peptide C-terminal residue.	Arginine	172-180	nuclear RNA export factor 1	Rattus norvegicus	117-120
8683475-0	1996	Activation of L-arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells.	Arginine	14-24	insulin	Homo sapiens	97-104
8683475-2	1996	Modulation of L-arginine transport (system y+) and release of nitric oxide (NO) and prostacyclin (PGI2) by elevated glucose and insulin were investigated in human cultured umbilical vein endothelial cells.	Arginine	14-24	insulin	Homo sapiens	128-135
8683475-10	1996	Insulin induced a protein synthesis-dependent stimulation of L-arginine transport and increased NO and PGI2 production in cells exposed to 5 mM glucose.	Arginine	61-71	insulin	Homo sapiens	0-7
8683475-12	1996	In cells exposed to high glucose, insulin downregulated elevated rates of L-arginine transport and cGMP accumulation but had no effect on the depressed PGI2 production.	Arginine	74-84	insulin	Homo sapiens	34-41
8598655-6	1996	Incubation of EMT-6 with LPS and IFN stimulated arginine transport approximately 70% over control levels at 12 hr and transport returned to basal levels at 24 hr.	Arginine	48-56	IL2 inducible T cell kinase	Mus musculus	14-17
8598655-6	1996	Incubation of EMT-6 with LPS and IFN stimulated arginine transport approximately 70% over control levels at 12 hr and transport returned to basal levels at 24 hr.	Arginine	48-56	interferon gamma	Mus musculus	33-36
8598655-9	1996	Finally, L-arginine was necessary in the media for nitrite accumulation by LPS/IFN-stimulated cells, with maximal accumulation at 1 mM L-arginine.	Arginine	9-19	interferon gamma	Mus musculus	79-82
8598655-9	1996	Finally, L-arginine was necessary in the media for nitrite accumulation by LPS/IFN-stimulated cells, with maximal accumulation at 1 mM L-arginine.	Arginine	135-145	interferon gamma	Mus musculus	79-82
8598655-10	1996	In summary, LPS/IFN stimulate arginine transport and NO production in the EMT-6 breast cancer cell line.	Arginine	30-38	interferon gamma	Mus musculus	16-19
8552098-4	1996	Like the src homology 2 (SH2) domains which bind phosphotyrosine-containing peptides, phosphoserine 133 appears to coordinate with a single arginine residue (Arg-600) in KIX which is conserved in the CBP-related protein P300.	Arginine	158-161	CREB binding protein	Homo sapiens	200-203
8598655-12	1996	LPS/IFN stimulation of arginine transport may represent an adaptive response to provide increased substrate for enhanced tumor cell NO production.	Arginine	23-31	interferon gamma	Mus musculus	4-7
8848170-4	1996	On the contrary, when either an activator of protein kinase C (phorbol ester), or an nitric oxide donor (L-arginine), were given with glutamate, they mimicked only the acute effects of insulin-like growth factor-I on glutamate-induced GABA release.	Arginine	105-115	insulin like growth factor 1	Homo sapiens	185-213
8868303-1	1996	We have synthesized eight analogues of the linear vasopressin antagonist DTyr(Et)2-Phe3-Gln4-Asn5-Arg6-Pro7-Arg8-Tyr(NH2)9 substituted with L-, or D-, pyroglutamate at position-1, Asn or Val at position-4 and Arg or Met at position 6.	Arginine	98-101	arginine vasopressin	Homo sapiens	50-61
8635577-3	1996	We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4.	Arginine	109-117	apolipoprotein E	Homo sapiens	89-93
8635577-3	1996	We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4.	Arginine	109-117	apolipoprotein E	Homo sapiens	155-160
8635577-5	1996	It was previously shown that arginine 61 was critical in determining apoE4 lipoprotein distribution in humans.	Arginine	29-37	apolipoprotein E	Homo sapiens	69-74
8602361-2	1996	Editing of NF1 mRNA modifies cytidine in an arginine codon (CGA) at nucleotide 2914 to a uridine (UGA), creating an in frame translation stop codon.	Arginine	44-52	neurofibromin 1	Homo sapiens	11-14
8602361-2	1996	Editing of NF1 mRNA modifies cytidine in an arginine codon (CGA) at nucleotide 2914 to a uridine (UGA), creating an in frame translation stop codon.	Arginine	44-52	chromogranin A	Homo sapiens	60-63
8637720-0	1996	Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.	Arginine	25-28	melanoma antigen	Mus musculus	21-24
8637720-0	1996	Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.	Arginine	97-100	melanoma antigen	Mus musculus	21-24
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	33-36	melanoma antigen	Mus musculus	29-32
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	melanoma antigen	Mus musculus	112-115
8745402-3	1996	Catalytic rate measurements on single and double mutants indicate that pK1 is mainly due to the deprotonation of Lys 120 and Lys 134, with only a minor contribution from other surface basic residues, whereas pK2 is due to titration of the invariant Arg 141, likely coupled to deprotonation of the copper-bound water molecule.	Arginine	249-252	prokineticin 2 S homeolog	Xenopus laevis	208-211
8769765-7	1996	Similarly, L-arginine, (3 x 10(-4) M) but not its stereoisomer D-arginine (3 x 10(-4) M), significantly reduced ANF secretion.	Arginine	11-21	natriuretic peptide A	Homo sapiens	112-115
9046361-9	1996	However, in Arg-induced acute pancreatitis, both the TNF-alpha (15.1 +/- 6.9 U/ml) and the IL-6 (39.6 +/- 19.2 pg/ml) levels were already elevated significantly at 12 h vs. the controls (3.1 +/- 0.8 U/ml and 15.2 +/- 3.1 pg/ml, respectively) and remained elevated at 24 and 48 h. Simultaneous KSG-504 administration did not modify the measured cytokine levels.	Arginine	12-15	tumor necrosis factor	Rattus norvegicus	53-62
9046361-9	1996	However, in Arg-induced acute pancreatitis, both the TNF-alpha (15.1 +/- 6.9 U/ml) and the IL-6 (39.6 +/- 19.2 pg/ml) levels were already elevated significantly at 12 h vs. the controls (3.1 +/- 0.8 U/ml and 15.2 +/- 3.1 pg/ml, respectively) and remained elevated at 24 and 48 h. Simultaneous KSG-504 administration did not modify the measured cytokine levels.	Arginine	12-15	interleukin 6	Rattus norvegicus	91-95
8861006-12	1996	These studies suggest that the proteolytic activity in the bacterial vesicles that is responsible for cleaving C5aR is primarily a non-tryptic proteinase, distance from either Arg- or Lys-gingipain.	Arginine	176-179	complement C5a receptor 1	Homo sapiens	111-115
8993775-5	1996	Amino acid analysis indicates that LSF is a peptide composed of Asp, Glu, Ser, Thr, Ala, Gly, Arg and probably Met, with the N-terminus blocked, possibly by pyroglutamic acid.	Arginine	94-97	transcription factor CP2	Mus musculus	35-38
8631370-3	1996	This part of the molecule is thought to contain part of the ligand-binding pocket, specifically to bind the C-terminal Arg of human C5a.	Arginine	119-122	complement C5a receptor 1	Homo sapiens	132-135
8561606-7	1996	These effects of endothelin-1 were offset to equal the values observed in controls having unmodified reperfusion by adding L-arginine.	Arginine	123-133	endothelin 1	Homo sapiens	17-29
8913543-6	1996	Vasodilator responses to bradykinin are antagonized by the B2-receptor icatibant and are blunted (but not abolished) by inhibition of the L-arginine/NO pathway with L-NG-monomethyl arginine.	Arginine	138-148	kininogen 1	Homo sapiens	25-35
8717347-2	1996	The deduced amino acid sequences of these two cDNAs, fGluR2 alpha and fGluR2 beta, display the highest sequence identity (85%) to that of the rat GluR2 (AMPA receptor subunit) and they contain an arginine codon at the Q/R editing site of the TM2 segment.	Arginine	196-204	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	54-59
8550313-13	1996	Cell adhesion to fibronectin and vitronectin was inhibited by peptides containing the Arg-Gly-Asp sequence.	Arginine	86-89	fibronectin 1	Homo sapiens	17-28
8682150-0	1996	Apolipoprotein E2 (Arg-136--&gt;Cys), a variant of apolipoprotein E associated with late-onset dominance of type III hyperlipoproteinaemia.	Arginine	19-22	apolipoprotein E	Homo sapiens	0-17
8682150-1	1996	Type III hyperlipoproteinaemia (HLP) is usually associated with homozygosity for apolipoprotein (apo) E2 (arg-158--&gt;Cys).	Arginine	106-109	apolipoprotein E	Homo sapiens	81-104
8616947-7	1996	Urinary NO3- excretion increased by 131.8 +/- 39.5% after L-arginine (P&lt;.05) but only by 32.3 +/- 17.2% after PGE1 (P=NS).	Arginine	58-68	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
8616947-12	1996	Increased urinary NO3- excretion may be a sum effect of NO synthase substrate provision (L-arginine) and increased shear stress (PGE1 and L-arginine).	Arginine	89-99	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
8616947-12	1996	Increased urinary NO3- excretion may be a sum effect of NO synthase substrate provision (L-arginine) and increased shear stress (PGE1 and L-arginine).	Arginine	138-148	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
8950617-6	1996	The most widely established criterion is the peak serum GH concentration achieved during a provocative test, usually the insulin tolerance test (ITT), or following other pharmacological stimuli (e.g. glucagon, arginine, clonidine or GH-releasing factor) but, alternatively, a more physiological stimulus (such as sleep, fasting or exercise) has been used.	Arginine	210-218	growth hormone 1	Homo sapiens	56-58
8592060-7	1996	The reduction of CGRP-induced increase of blood flow by L-NAME was reversed by L-arginine.	Arginine	79-89	calcitonin related polypeptide alpha	Homo sapiens	17-21
8698744-4	1996	Sequencing of the corresponding region has confirmed preliminary data indicating that the single-base changes CGT (Arg) to TGT (Cys) or CGT to CAT (His) occurred.	Arginine	115-118	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	123-126
8745290-2	1996	We have investigated whether changes in extracellular ion composition and substrate deprivation modulate basal and/or bradykinin-stimulated L-arginine transport and release of nitric oxide (NO) and prostacyclin (PGI2) in porcine aortic endothelial cells cultured and superfused on microcarriers.	Arginine	140-150	kininogen 1	Homo sapiens	118-128
8745290-15	1996	Bradykinin-stimulated L-arginine transport was insensitive to removal of Ca2+, whereas agonist-induced NO release was abolished.	Arginine	22-32	kininogen 1	Homo sapiens	0-10
8788263-3	1996	METHODS: To further study this relationship, we examined the effects of LPS, TNF, and dexamethasone (DEX) on arginine uptake by rat lung microvascular endothelial cells.	Arginine	109-117	tumor necrosis factor	Rattus norvegicus	77-80
10608036-1	1996	Arg-Gly-Asp (RGD)-containing peptides and the peptide unique to fibrinogen in the C-terminal domain of the gamma chain are important for fibrinogen binding to platelet membrane glycoprotein (GP) II b/III a.	Arginine	0-3	fibrinogen beta chain	Homo sapiens	137-147
8788263-6	1996	Arginine transport was stimulated independently by LPS and TNF, a response first observed at 10 hours.	Arginine	0-8	tumor necrosis factor	Rattus norvegicus	59-62
8788263-8	1996	The LPS- and TNF-induced increase in arginine transport activity was blocked by cycloheximide and actinomycin D, indicating the requirement for RNA and protein synthesis.	Arginine	37-45	tumor necrosis factor	Rattus norvegicus	13-16
8788263-12	1996	CONCLUSIONS: These data indicate that LPS and TNF additively stimulate arginine transport in lung microvascular endothelial cells via a pathway that requires de novo protein synthesis (possibly of the transporter protein itself) and that this response is attenuated by DEX.	Arginine	71-79	tumor necrosis factor	Rattus norvegicus	46-49
8699928-3	1996	TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation.	Arginine	53-56	interleukin 1 beta	Rattus norvegicus	19-28
8699928-4	1996	These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation.	Arginine	141-144	interleukin 1 beta	Rattus norvegicus	47-56
8865363-6	1996	The complex leads to full spatial and energetic definition of the receptor proton shuttle mechanism, while there is a striking association of further Tyrosine and Arginine residues in the vicinity of the Gs alpha-protein Asn-Gln interaction.	Arginine	163-171	GNAS complex locus	Homo sapiens	204-212
8809229-2	1996	The synthesis of TNF-alpha in J774 macrophages stimulated with LPS (0.1 microgram/ml) was increased in concentration-related fashion by NO synthase inhibitor L-NMMA (3-30-300 microM) and reduced by either L-arginine (3-30-300 microM) or the NO donor SIN-1 (1-10-100 microM).	Arginine	205-215	tumor necrosis factor	Homo sapiens	17-26
8983811-3	1996	NO is synthesised from L-arginine by a family of enzymes called Nitric oxide synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	64-85
8899819-2	1996	Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay.	Arginine	35-38	proopiomelanocortin	Homo sapiens	67-70
8742481-0	1995	The post-translational incorporation of arginine into a beta-amyloid peptide increases the probability of alpha-helix formation.	Arginine	40-48	amyloid beta precursor protein	Homo sapiens	56-76
8928490-1	1996	Recently, the polymorphism of a new human platelet antigen, Ca/Tu, was shown to be derived from a G-A nucleotide substitution at base 1564 of GPIIIa cDNA, which leads to a single amino acid difference, Arg/Gln at amino acid 489 of GPIIIa.	Arginine	202-205	integrin subunit beta 3	Homo sapiens	142-148
8928490-1	1996	Recently, the polymorphism of a new human platelet antigen, Ca/Tu, was shown to be derived from a G-A nucleotide substitution at base 1564 of GPIIIa cDNA, which leads to a single amino acid difference, Arg/Gln at amino acid 489 of GPIIIa.	Arginine	202-205	integrin subunit beta 3	Homo sapiens	231-237
8742481-1	1995	The beta-amyloid peptide (beta AP1-40) inhibited the in vitro post-translational incorporation of [14C]arginine at the N-terminus of brain soluble proteins and was labelled by the incorporation of [14C]arginine.	Arginine	103-111	amyloid beta precursor protein	Homo sapiens	4-24
8742481-1	1995	The beta-amyloid peptide (beta AP1-40) inhibited the in vitro post-translational incorporation of [14C]arginine at the N-terminus of brain soluble proteins and was labelled by the incorporation of [14C]arginine.	Arginine	103-111	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-34
8742481-1	1995	The beta-amyloid peptide (beta AP1-40) inhibited the in vitro post-translational incorporation of [14C]arginine at the N-terminus of brain soluble proteins and was labelled by the incorporation of [14C]arginine.	Arginine	202-210	amyloid beta precursor protein	Homo sapiens	4-24
8742481-1	1995	The beta-amyloid peptide (beta AP1-40) inhibited the in vitro post-translational incorporation of [14C]arginine at the N-terminus of brain soluble proteins and was labelled by the incorporation of [14C]arginine.	Arginine	202-210	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-34
8742481-2	1995	Addition of arginine at the N-terminal position of beta AP1-40 is predicted to increase the probability of an alpha-helix structure being formed on the first residues with a higher hydrophilic characteristic, increasing the possibility of these residues being exposed to the aqueous environment.	Arginine	12-20	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	56-59
8521573-5	1995	The effects of both CCh and BK but not SNAP were eliminated by nitro-L-arginine (NLA, 10(-4) mol/L), consistent with SNAP decomposing to release NO and both CCh and BK stimulating endogenous NO production from L-arginine.	Arginine	69-79	kininogen 1	Canis lupus familiaris	28-30
8530370-7	1995	We next tested the hypothesis that a positively charged arginine residue (Arg209) within the transmembrane domain of Fc alpha R promotes association with FcR gamma chain.	Arginine	56-64	Fc alpha receptor	Homo sapiens	117-127
8736266-14	1995	ARG increased the GHRH-induced GH rise in both groups, but in OB the GH response to ARG+GHRH (1458.4 +/- 439.0 mU/l/h, P &lt; 0.03 vs GHRH alone) remained lower (P &lt; 0.0001) than in CS (6396.2 +/- 772.2 mU/l/h, P &lt; 0.01 vs GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	18-22
7495809-2	1995	A mutant 17-kringle from of r-apo(a) was engineered that contained a serine to arginine substitution which reinstates the tissue-type plasminogen activator (tPA) as determined by SDS-PAGE and fluorography and by Western blot analysis.	Arginine	79-87	plasminogen activator, tissue type	Homo sapiens	122-155
7495809-2	1995	A mutant 17-kringle from of r-apo(a) was engineered that contained a serine to arginine substitution which reinstates the tissue-type plasminogen activator (tPA) as determined by SDS-PAGE and fluorography and by Western blot analysis.	Arginine	79-87	plasminogen activator, tissue type	Homo sapiens	157-160
7495809-6	1995	Treatment of the Ser--&gt;Arg mutant of the 17-kringle r-apo(a) with tPA and diisopropylflurophosphate (DFP) did not result in modification of the mutant protease domain by DFP.	Arginine	26-29	plasminogen activator, tissue type	Homo sapiens	69-72
8572217-1	1995	Hepatocytes can be stimulated to express high levels of inducible nitric oxide synthase (iNOS), which utilizes arginine for nitric oxide (NO) synthesis.	Arginine	111-119	nitric oxide synthase 2	Rattus norvegicus	56-87
8572217-1	1995	Hepatocytes can be stimulated to express high levels of inducible nitric oxide synthase (iNOS), which utilizes arginine for nitric oxide (NO) synthesis.	Arginine	111-119	nitric oxide synthase 2	Rattus norvegicus	89-93
8572217-3	1995	To identify the sources of arginine for iNOS, we measured the release of NO-2 + NO-3 and urea in isolated rat livers perfused in a recirculation model with a Krebs-Henseleit-bicarbonate buffer containing either no added amino acid, arginine, or precursors for urea synthesis.	Arginine	27-35	nitric oxide synthase 2	Rattus norvegicus	40-44
8572217-5	1995	In livers from C. parvum- and endotoxin-treated rats, we found that 1) an intracellular source of arginine exists that provides substrate to iNOS; 2) additional exogenous arginine increase NO synthesis, demonstrating that endogenous arginine is insufficient for maximal NO synthesis; and 3) an increase in the rate of endogenous arginine synthesis within the urea cycle is inefficient in increasing NO synthesis, demonstrating the independence of the two pathways in the liver.	Arginine	98-106	nitric oxide synthase 2	Rattus norvegicus	141-145
8572217-5	1995	In livers from C. parvum- and endotoxin-treated rats, we found that 1) an intracellular source of arginine exists that provides substrate to iNOS; 2) additional exogenous arginine increase NO synthesis, demonstrating that endogenous arginine is insufficient for maximal NO synthesis; and 3) an increase in the rate of endogenous arginine synthesis within the urea cycle is inefficient in increasing NO synthesis, demonstrating the independence of the two pathways in the liver.	Arginine	171-179	nitric oxide synthase 2	Rattus norvegicus	141-145
8572217-5	1995	In livers from C. parvum- and endotoxin-treated rats, we found that 1) an intracellular source of arginine exists that provides substrate to iNOS; 2) additional exogenous arginine increase NO synthesis, demonstrating that endogenous arginine is insufficient for maximal NO synthesis; and 3) an increase in the rate of endogenous arginine synthesis within the urea cycle is inefficient in increasing NO synthesis, demonstrating the independence of the two pathways in the liver.	Arginine	171-179	nitric oxide synthase 2	Rattus norvegicus	141-145
8572217-5	1995	In livers from C. parvum- and endotoxin-treated rats, we found that 1) an intracellular source of arginine exists that provides substrate to iNOS; 2) additional exogenous arginine increase NO synthesis, demonstrating that endogenous arginine is insufficient for maximal NO synthesis; and 3) an increase in the rate of endogenous arginine synthesis within the urea cycle is inefficient in increasing NO synthesis, demonstrating the independence of the two pathways in the liver.	Arginine	171-179	nitric oxide synthase 2	Rattus norvegicus	141-145
7493972-0	1995	Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.	Arginine	0-8	prostaglandin-endoperoxide synthase 1	Homo sapiens	16-44
7493972-2	1995	From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid group of flurbiprofen is located in a favorable position for interacting with the arginine 120 residue of PGHS-1 (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249).	Arginine	172-180	prostaglandin G/H synthase 1	Ovis aries	36-42
7493972-2	1995	From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid group of flurbiprofen is located in a favorable position for interacting with the arginine 120 residue of PGHS-1 (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249).	Arginine	172-180	prostaglandin G/H synthase 1	Ovis aries	196-202
8749813-5	1995	Blockade of the activity of NO synthase (NOS), the enzyme responsible for NO formation, with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME), augmented the ACTH response to IL-1 beta or LPS in both control (C) and EtOH-fed (E) rats.	Arginine	97-105	interleukin 1 beta	Rattus norvegicus	197-206
8821467-1	1995	Nitric oxide (NO) is generated from L-arginine by the family of isoenzymes called NO synthases (NOS).	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	82-94
8736266-14	1995	ARG increased the GHRH-induced GH rise in both groups, but in OB the GH response to ARG+GHRH (1458.4 +/- 439.0 mU/l/h, P &lt; 0.03 vs GHRH alone) remained lower (P &lt; 0.0001) than in CS (6396.2 +/- 772.2 mU/l/h, P &lt; 0.01 vs GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	88-92
8736266-14	1995	ARG increased the GHRH-induced GH rise in both groups, but in OB the GH response to ARG+GHRH (1458.4 +/- 439.0 mU/l/h, P &lt; 0.03 vs GHRH alone) remained lower (P &lt; 0.0001) than in CS (6396.2 +/- 772.2 mU/l/h, P &lt; 0.01 vs GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	88-92
8736266-14	1995	ARG increased the GHRH-induced GH rise in both groups, but in OB the GH response to ARG+GHRH (1458.4 +/- 439.0 mU/l/h, P &lt; 0.03 vs GHRH alone) remained lower (P &lt; 0.0001) than in CS (6396.2 +/- 772.2 mU/l/h, P &lt; 0.01 vs GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	88-92
7499427-3	1995	ACE release in Chinese hamster ovary cells involves a proteolytic cleavage occurring in the carboxyl-terminal region, between Arg-1137 and Leu-1138.	Arginine	126-129	angiotensin-converting enzyme	Cricetulus griseus	0-3
8714213-6	1995	The two highly expressed genes of AcNPV, polh and the p10, differ from the overall AcNPV codon usage profile with respect to at least nine amino acids (Val, Ala, Ser, Lys, Ile, Thr, Leu, Phe, Arg).	Arginine	192-195	fibrous body protein	Autographa californica nucleopolyhedrovirus	54-57
8587245-10	1995	Glomerular ET-1 mRNA levels and protein immunostaining declined in the rats receiving L-arginine.	Arginine	86-96	endothelin 1	Rattus norvegicus	11-15
7565304-7	1995	In addition, one of 15 PNETs retained heterozygosity but demonstrated a somatic CGT to TGT transition (arg to cys) at codon 273.	Arginine	103-106	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	87-90
8587245-11	1995	We conclude that dietary supplementation with L-arginine reduces early cell proliferation in the remnant glomerulus, an effect that may be mediated, in part, by a decrease in ET-1 production.	Arginine	46-56	endothelin 1	Rattus norvegicus	175-179
7499198-0	1995	Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase.	Arginine	75-85	nitric oxide synthase 2	Homo sapiens	140-161
8747120-6	1995	In response to L-dopa and arginine hydrochloride stimulation, serum GH rose to above 7 mg/ml in all patients.	Arginine	26-48	growth hormone 1	Homo sapiens	68-70
8752390-13	1995	Although plasma levels of CGRP decreased significantly in controls following L-arginine infusion, those of CGRP did not change in migraine patients.	Arginine	77-87	calcitonin related polypeptide alpha	Homo sapiens	26-30
8719415-5	1995	Thus, certain amidines are potent inhibitors of NO synthase, and are more selective towards the inducible NO synthase than the commonly used L-arginine based NO synthase inhibitors.	Arginine	141-151	nitric oxide synthase 2	Rattus norvegicus	96-117
8771058-5	1995	The reduced amount of plasma L-arginine leads to decreased secretion of growth hormone and insulin-like growth factor-1 during exercise.	Arginine	29-39	insulin	Homo sapiens	91-98
8786727-7	1995	Similar GH responses were observed in normal controls and alcoholic subjects when GHRH or arginine were administered.	Arginine	90-98	growth hormone 1	Homo sapiens	8-10
8786727-9	1995	These data show that alcoholism is associated with an impairment in the serotonergic-stimulatory regulation of GH secretion, whereas GH responses to direct pituitary stimulation with GHRH or to release from somatostatinergic inhibition with arginine appear to be preserved in alcoholics.	Arginine	241-249	growth hormone 1	Homo sapiens	133-135
7479976-5	1995	Conservative Lys--&gt;Arg substitutions at both Lys-21 and Lys-22 produce dominant-negative mutants of I kappa B alpha in vivo.	Arginine	22-25	NFKB inhibitor alpha	Homo sapiens	103-118
7479976-7	1995	Moreover, these Lys--&gt;Arg mutations prevent signal-dependent degradation of I kappa B alpha in vivo and ubiquitin conjugation in vitro.	Arginine	25-28	NFKB inhibitor alpha	Homo sapiens	79-94
7499219-2	1995	Ang II stimulated the uptake rates of radiolabeled arginine and lysine in a time- and concentration-dependent manner.	Arginine	51-59	angiotensinogen	Rattus norvegicus	0-6
7499198-1	1995	Nitric oxide synthase (NOS) catalyzes sequential NADPH- and O2-dependent mono-oxygenase reactions converting L-arginine to N omega-hydroxy-L-arginine and N omega-hydroxy-L-arginine to citrulline and nitric oxide.	Arginine	109-119	nitric oxide synthase 2	Homo sapiens	0-21
7499219-3	1995	The stimulated arginine uptake could be blocked by pretreatments with cycloheximide and actinomycin D or co-treatment with valsartan, an antagonist specific for Ang II receptor subtype-1.	Arginine	15-23	angiotensinogen	Rattus norvegicus	161-167
7499219-4	1995	The modulation by Ang II was bidirectional as the efflux of arginine was also stimulated, 5-fold over basal.	Arginine	60-68	angiotensinogen	Rattus norvegicus	18-24
7491940-6	1995	Urea production and excretion were reduced significantly with arginine supplementation, suggesting an anabolic effect on the whole body nitrogen economy, possibly via the raised plasma insulin levels (P = 0.013) during the prandial phase.	Arginine	62-70	insulin	Homo sapiens	185-192
7488171-1	1995	Endothelial nitric oxide synthase (eNOS) is an important oxygenase which catalyzes the conversion of L-arginine to L-citrulline to form nitric oxide (NO), a potent important factor for vasodilation and inhibition of platelet aggregation.	Arginine	101-111	nitric oxide synthase 3	Homo sapiens	0-33
7488171-1	1995	Endothelial nitric oxide synthase (eNOS) is an important oxygenase which catalyzes the conversion of L-arginine to L-citrulline to form nitric oxide (NO), a potent important factor for vasodilation and inhibition of platelet aggregation.	Arginine	101-111	nitric oxide synthase 3	Homo sapiens	35-39
7577473-5	1995	Analysis of WAF1/CIP1 revealed multiple polymorphisms, the most abundant being AGC--&gt;AGA (Ser--&gt;Arg) at codon 31 with an allele frequency of 8.5%.	Arginine	102-105	cyclin dependent kinase inhibitor 1A	Homo sapiens	12-16
7583591-7	1995	L-NAME, thrombin, and PMA also significantly increased polymorphonuclear leukocyte adherence to the coronary artery endothelium, an effect that was significantly attenuated by the anti-P-selectin monoclonal antibody PB1.3 or by UCN-01, L-arginine, 8-bromo-cGMP or SNP but not by D-arginine or he nonblocking anti-P-selectin monoclonal antibody NBP1.6.	Arginine	236-246	coagulation factor II, thrombin	Homo sapiens	8-16
7577473-5	1995	Analysis of WAF1/CIP1 revealed multiple polymorphisms, the most abundant being AGC--&gt;AGA (Ser--&gt;Arg) at codon 31 with an allele frequency of 8.5%.	Arginine	102-105	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-21
8581283-12	1995	L-Arginine reversed the L-NAME-induced inhibition of release of CGRP, the concentration of CGRP in the aqueous humour being 9.7 +/- 0.6 nmol l-1.	Arginine	0-10	calcitonin related polypeptide alpha	Homo sapiens	64-68
8581283-12	1995	L-Arginine reversed the L-NAME-induced inhibition of release of CGRP, the concentration of CGRP in the aqueous humour being 9.7 +/- 0.6 nmol l-1.	Arginine	0-10	calcitonin related polypeptide alpha	Homo sapiens	91-95
7590659-5	1995	In both groups, a similar increase of plasma atrial natriuretic factor (ANF) was seen with L-arginine and saline infusions; endothelin and catecholamines were not affected by either infusion.	Arginine	91-101	natriuretic peptide A	Homo sapiens	45-70
8722075-3	1995	RESULTS: Initial insulin secretory responses were severely decreased when the patients were compared with eight healthy control subjects: IVGTT (1 + 3 min): 106 +/- 16 vs. 884 +/- 190 pmol/l (P &lt; 0.001); hyperglycemic clamp: 102 +/- 16 vs. 310 +/- 42 pmol/l (P &lt; 0.001); intravenous arginine: 346 +/- 72 vs. 1104 +/- 168 pmol/l (P &lt; 0.01); and intravenous glucagon: 170 +/- 37 vs. 247 +/- 35 pmol/l (NS).	Arginine	289-297	insulin	Homo sapiens	17-24
8869014-6	1995	There is also clinical experience with argatroban, an arginine derivative which is a competitive antagonist to thrombin.	Arginine	54-62	coagulation factor II, thrombin	Homo sapiens	111-119
7590659-5	1995	In both groups, a similar increase of plasma atrial natriuretic factor (ANF) was seen with L-arginine and saline infusions; endothelin and catecholamines were not affected by either infusion.	Arginine	91-101	natriuretic peptide A	Homo sapiens	72-75
7594039-11	1995	Clearance of NO2/NO3 increased significantly during L-arginine administration (from 13.28 +/- 0.42 ml/min to 29.97 +/- 1.09 ml/min, p &lt; 0.001).	Arginine	52-62	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
7577932-1	1995	Nitric oxide synthases (NOS) require NADPH and tetrahydrobiopterin (H4biopterin) to convert L-arginine to L-citrulline.	Arginine	92-102	nitric oxide synthase 2	Homo sapiens	0-22
7581448-4	1995	A Thr-to-Arg missense mutation was identified within the beta-sarcoglycan gene that leads to a dramatically reduced expression of beta-sarcoglycan in the sarcolemma and a concomitant loss of adhalin and 35 DAG, which may represent a disruption of a functional subcomplex within the dystrophin-glycoprotein complex.	Arginine	9-12	sarcoglycan beta	Homo sapiens	57-73
7581448-4	1995	A Thr-to-Arg missense mutation was identified within the beta-sarcoglycan gene that leads to a dramatically reduced expression of beta-sarcoglycan in the sarcolemma and a concomitant loss of adhalin and 35 DAG, which may represent a disruption of a functional subcomplex within the dystrophin-glycoprotein complex.	Arginine	9-12	sarcoglycan beta	Homo sapiens	130-146
7581448-4	1995	A Thr-to-Arg missense mutation was identified within the beta-sarcoglycan gene that leads to a dramatically reduced expression of beta-sarcoglycan in the sarcolemma and a concomitant loss of adhalin and 35 DAG, which may represent a disruption of a functional subcomplex within the dystrophin-glycoprotein complex.	Arginine	9-12	sarcoglycan alpha	Homo sapiens	191-198
7594684-5	1995	The only amino acid substitution consistently associated with reduced CD4 cell counts, cytopathic effect, and progression to AIDS was Arg at position 11.	Arginine	134-137	CD4 molecule	Homo sapiens	70-73
7478648-9	1995	L-Arginine analogs (10(-4) to 10(-2) mol/L) inhibited the effect of substance P (p &lt; 0.02 at the higher concentration).	Arginine	0-10	tachykinin precursor 1	Homo sapiens	68-79
7478648-10	1995	This inhibition was reversed by adding L-arginine, demonstrating that nitric oxide production is a required step in substance P-induced ciliostimulation.	Arginine	39-49	tachykinin precursor 1	Homo sapiens	116-127
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	38-41	myosin, heavy chain 9, non-muscle	Gallus gallus	129-135
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	38-41	myosin, heavy chain 9, non-muscle	Gallus gallus	169-175
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	129-135
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	169-175
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	129-135
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	169-175
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	129-135
7559573-8	1995	By sequence comparison, six residues, Arg-103, Arg-123, Met-129, Gly-130, Arg-143, and Arg-160, which are conserved in regulated myosin RLCs but missing in nonregulated myosin RLCs, were identified in smRLC.	Arginine	47-50	myosin, heavy chain 9, non-muscle	Gallus gallus	169-175
7581965-5	1995	As the GHRH-induced GH rise in children is potentiated by arginine (ARG), even when administered by oral route at low dose (4 g), we studied also the interaction of oral GHRP-6 and ARG administration.	Arginine	58-66	growth hormone releasing hormone	Homo sapiens	7-11
7563081-9	1995	Sequence comparison between mammalian fibrinopeptides A and B suggests that the specificity of thrombin is dictated by a four-residue consensus motif, Phe(P4)-Xxx(P3)-Pro(P2)-Arg(P1) or FXPR, when Xxx at P3 can be a charged or a neutral polar residue capable of specific interactions with residues near the active site of thrombin.	Arginine	175-178	coagulation factor II, thrombin	Homo sapiens	95-103
8547593-7	1995	ADC and iNOS enzymes synthesizing distinct bioactive products from L-arginine, may be reciprocally regulated.	Arginine	67-77	nitric oxide synthase 2	Homo sapiens	8-12
7487915-15	1995	These data establish that a minimum structure at the C-terminus of GLUT1, which is required for the conformational change to expose the exofacial site, includes amino acids at positions Phe-467 and Arg-468; however, these amino acids are not individually essential.	Arginine	198-201	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	67-72
7561142-6	1995	Substitution of glycine for amino acid in position 123 (arginine, R), 124 (lysine, K), 126 (R) or 128 (K) in a MAGE-4b oligopeptide of the position 119-132 severely decreased the reactivity of the R5 mAb to the oligopeptide.	Arginine	56-64	MAGE family member A4	Homo sapiens	111-118
7548140-0	1995	Protein kinase C-dependent regulation of L-arginine transport activity in Caco-2 intestinal cells.	Arginine	41-51	proline rich transmembrane protein 2	Homo sapiens	0-16
8801862-4	1995	NO-dependent cGMP production in the cells (passage 1; preincubated in L-arginine-free medium for 24 h) was stimulated for 3 min with bradykinin (BK 1 nM) or the calcium-ionophore A23187 (100 nM) or by a 20 min incubation with L-arginine (L-Arg 0.1 mM, 20 min).	Arginine	70-80	kininogen 1	Homo sapiens	133-143
8801862-4	1995	NO-dependent cGMP production in the cells (passage 1; preincubated in L-arginine-free medium for 24 h) was stimulated for 3 min with bradykinin (BK 1 nM) or the calcium-ionophore A23187 (100 nM) or by a 20 min incubation with L-arginine (L-Arg 0.1 mM, 20 min).	Arginine	226-236	kininogen 1	Homo sapiens	133-143
8801862-4	1995	NO-dependent cGMP production in the cells (passage 1; preincubated in L-arginine-free medium for 24 h) was stimulated for 3 min with bradykinin (BK 1 nM) or the calcium-ionophore A23187 (100 nM) or by a 20 min incubation with L-arginine (L-Arg 0.1 mM, 20 min).	Arginine	238-243	kininogen 1	Homo sapiens	133-143
7581965-5	1995	As the GHRH-induced GH rise in children is potentiated by arginine (ARG), even when administered by oral route at low dose (4 g), we studied also the interaction of oral GHRP-6 and ARG administration.	Arginine	68-71	growth hormone releasing hormone	Homo sapiens	7-11
7581965-5	1995	As the GHRH-induced GH rise in children is potentiated by arginine (ARG), even when administered by oral route at low dose (4 g), we studied also the interaction of oral GHRP-6 and ARG administration.	Arginine	181-184	growth hormone releasing hormone	Homo sapiens	7-11
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Arginine	364-367	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
21552920-4	1995	Particularly, 3 of 4 nonsense mutations detected in the present study were found in codon 80 (CGA--&gt;TGA; Arg--&gt;Stop), suggesting that codon 80 was a mutational hot spot of the p16/CDKN2 gene.	Arginine	108-111	chromogranin A	Homo sapiens	94-97
21552920-4	1995	Particularly, 3 of 4 nonsense mutations detected in the present study were found in codon 80 (CGA--&gt;TGA; Arg--&gt;Stop), suggesting that codon 80 was a mutational hot spot of the p16/CDKN2 gene.	Arginine	108-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	182-185
21552920-4	1995	Particularly, 3 of 4 nonsense mutations detected in the present study were found in codon 80 (CGA--&gt;TGA; Arg--&gt;Stop), suggesting that codon 80 was a mutational hot spot of the p16/CDKN2 gene.	Arginine	108-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	186-191
8574328-0	1995	L-arginine and endogenous nitric oxide protect the gastric mucosa from endothelin-1-induced gastric ulcers in rats.	Arginine	0-10	endothelin 1	Rattus norvegicus	71-83
8574328-6	1995	Twenty-four h later, L-arginine, but not D-arginine, had significantly reduced the extent and the severity of the endothelin-1-induced ulcer (mucosal wall damage, 18.11 +/- 4.79% and 88.14 +/- 7.06%, respectively; mean +/- SD, P &lt; 0.001), and the nitric oxide synthesis inhibitor (10 mg/kg) had increased the endothelin-1-induced mucosal damage (ulcer length, 3.8 +/- 1.2 mm and 1.1 +/- 0.2 mm, respectively, P &lt; 0.01).	Arginine	21-31	endothelin 1	Rattus norvegicus	114-126
8574328-6	1995	Twenty-four h later, L-arginine, but not D-arginine, had significantly reduced the extent and the severity of the endothelin-1-induced ulcer (mucosal wall damage, 18.11 +/- 4.79% and 88.14 +/- 7.06%, respectively; mean +/- SD, P &lt; 0.001), and the nitric oxide synthesis inhibitor (10 mg/kg) had increased the endothelin-1-induced mucosal damage (ulcer length, 3.8 +/- 1.2 mm and 1.1 +/- 0.2 mm, respectively, P &lt; 0.01).	Arginine	21-31	endothelin 1	Rattus norvegicus	312-324
8574328-7	1995	Continuous gastric mucosal blood flow measurements showed that L-arginine antagonized the endothelin-1-induced vasoconstriction.	Arginine	63-73	endothelin 1	Rattus norvegicus	90-102
8574328-8	1995	L-arginine protected the gastric mucosa from the ulcerogenic action of endothelin-1 and antagonized its vasoconstrictive action.	Arginine	0-10	endothelin 1	Rattus norvegicus	71-83
7565672-1	1995	We examined the regulation of Neurospora crassa arg-2 and cpc-1 in response to amino acid availability.arg-2 encodes the small subunit of arginine-specific carbamoyl phosphate synthetase; it is subject to unique negative regulation by Arg and is positively regulated in response to limitation for many different amino acids through a mechanism known as cross-pathway control.	Arginine	235-238	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	103-108
7565672-4	1995	Analyses of mRNA levels, polypeptide pulse-labeling results, and the distribution of mRNA in polysomes indicated that Arg-specific negative regulation of arg-2 affected the levels of both arg-2 mRNA and arg-2 mRNA translation.	Arginine	118-121	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	154-159
7565672-4	1995	Analyses of mRNA levels, polypeptide pulse-labeling results, and the distribution of mRNA in polysomes indicated that Arg-specific negative regulation of arg-2 affected the levels of both arg-2 mRNA and arg-2 mRNA translation.	Arginine	118-121	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	188-193
7565672-4	1995	Analyses of mRNA levels, polypeptide pulse-labeling results, and the distribution of mRNA in polysomes indicated that Arg-specific negative regulation of arg-2 affected the levels of both arg-2 mRNA and arg-2 mRNA translation.	Arginine	118-121	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	188-193
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Arginine	364-367	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
7565714-2	1995	Structural analysis of the Src SH3 domain (Src SH3) complexed with proline-rich peptide ligands revealed three binding sites involved in this interaction: two hydrophobic interactions (between aliphatic proline dipeptides in the SH3 ligand and highly conserved aromatic residues on the surface of the SH3 domain), and one salt bridge (between Asp-99 of Src and an Arg three residues upstream of the conserved Pro-X-X-Pro motif in the ligand).	Arginine	364-367	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
8610212-5	1995	The inhibition by L-NAME was reversed by the addition of L-arginine in both MCh- and BK-induced secretions from isolated glands.	Arginine	57-67	kininogen 1	Homo sapiens	85-87
7559400-6	1995	These results suggested that the NAD(+)-dependent modification of the 31-kDa protein was due to ADP-ribosylation of glycosylphosphatidylinositol-anchored RT6.1 at an arginine residue.	Arginine	166-174	ADP-ribosyltransferase 2b	Rattus norvegicus	154-159
8560418-6	1995	These data suggested that LKd had an altered conformation which exposed the amino terminal arginine of bradykinin to antigenic detection.	Arginine	91-99	kininogen 1	Homo sapiens	103-113
8560426-1	1995	The possibility to induce specific disruption of activated platelets by binding of porcine pancreatic phospholipase A2 (PLA2) was tested by constructing a set of PLA2-mutants containing an Arg-Gly-Asp (RGD) sequence.	Arginine	189-192	phospholipase A2 group IB	Homo sapiens	102-118
8560426-1	1995	The possibility to induce specific disruption of activated platelets by binding of porcine pancreatic phospholipase A2 (PLA2) was tested by constructing a set of PLA2-mutants containing an Arg-Gly-Asp (RGD) sequence.	Arginine	189-192	phospholipase A2 group IB	Homo sapiens	120-124
7478990-6	1995	NIP1 and NIP2 have an RNP consensus-type RNA binding domain, whereas NIP3 contains a unique domain of Arg-Glu or Lys-Glu dipeptide repeats.	Arginine	102-105	BCL2 interacting protein 3	Homo sapiens	69-73
7559438-1	1995	Neuronal NO synthase (NOS) is a flavin-containing hemeprotein that generates NO from L-arginine, NADPH, and O2.	Arginine	85-95	nitric oxide synthase 2	Homo sapiens	9-20
7664438-2	1995	L-Arginine, the substrate for NO synthase (NOS), has a vasodilatory effect in systemic vascular beds and can correct abnormal endothelium-dependent vasodilation.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	30-41
7503422-3	1995	The results obtained with cathepsin A purified from human placenta demonstrate that the enzyme has the highest affinity for substrates with large hydrophobic (Phe, Leu) or positively charged (Arg) amino acid residues in P1" position.	Arginine	192-195	cathepsin A	Homo sapiens	26-37
7573503-5	1995	Complete nitric oxide synthase inhibition at this dose was indicated by the findings that co-administration of 2.5 mumol L-arginine reversed this constriction within 17 +/- 2 min (n = 3), that L-NMMA, but not D-NMMA, completely inhibited the 20 +/- 3% P &lt; 0.01) arteriolar dilation induced by intravitreal acetylcholine (7.5 nmol; n = 4), and that no additional constriction was evidenced after administration of a 10-fold greater concentration of L-NMMA (n = 8).	Arginine	121-131	nitric oxide synthase 2	Sus scrofa	9-30
7670940-6	1995	In the Finnish population, allele frequencies of the rare alleles of the apoB 1887 (Asn-->Ser) and apoB 1896 (His-->Arg) polymorphisms were .02 and .11, respectively.	Arginine	116-119	apolipoprotein B	Homo sapiens	99-103
8562658-4	1995	It is concluded that by virtue of the basic nature of the P1 (Arg) residue in the active center IT-1 is not capable to bind human granulocyte elastase.	Arginine	62-65	HAUS augmin like complex subunit 3	Homo sapiens	96-100
7556217-4	1995	It belongs to the sulfakinin family, all known members of which (from flies, cockroaches and locusts) have the C-terminal heptapeptide sequence Asp-Tyr(SO3)-Gly-His-Met-Arg-Phe-NH2.	Arginine	169-172	Drosulfakinin	Drosophila melanogaster	18-28
8567541-7	1995	The effects of Ro-24-9981 on substance P-induced responses were significantly attenuated by NG-nitro-L-arginine methyl ester and restored by L-arginine (P &lt; 0.05).	Arginine	101-111	tachykinin precursor 1	Homo sapiens	29-40
7657670-1	1995	The yeast YAP3 gene encodes an aspartyl endoprotease that cleaves precursor proteins at selected pairs of basic amino acids and after single arginine residues.	Arginine	141-149	Yap3p	Saccharomyces cerevisiae S288C	10-14
8554907-0	1995	Alanine substitution of two arginines in amino terminus of V3 of SIV disrupts CD4 binding whereas a similar replacement of two amino acids, lysine and arginine, in the carboxyl half of V3 prevents binding of a neutralizing monoclonal antibody.	Arginine	28-37	CD4 molecule	Homo sapiens	78-81
8554907-0	1995	Alanine substitution of two arginines in amino terminus of V3 of SIV disrupts CD4 binding whereas a similar replacement of two amino acids, lysine and arginine, in the carboxyl half of V3 prevents binding of a neutralizing monoclonal antibody.	Arginine	28-36	CD4 molecule	Homo sapiens	78-81
8585604-5	1995	Using the anti-hamster beta 1 monoclonal antibody 7E2 to capture alpha 5 beta 1 from a CHO#7 cell lysate, this SPA assay allowed measurement of specific 125I-fibronectin binding as defined by displacement by the Arg-Gly-Asp containing peptide GRGDSP or the anti-human alpha 5 antibody P1D6.	Arginine	212-215	fibronectin 1	Homo sapiens	158-169
7544575-3	1995	The addition of NG-monomethyl-L-arginine, a selective inhibitor of NO synthesis, reduced the effect of interferon-gamma and lipopolysaccharide, while the effect of NG-monomethyl-L-arginine was suppressed by the addition of L-arginine, a substrate of NO synthase.	Arginine	30-40	interferon gamma	Homo sapiens	103-119
8548867-3	1995	The cell adhesive region in the central portion of fibronectin is comprised of at least two minimal amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence--which function in synergy.	Arginine	125-128	fibronectin 1	Homo sapiens	51-62
8548867-3	1995	The cell adhesive region in the central portion of fibronectin is comprised of at least two minimal amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence--which function in synergy.	Arginine	170-173	fibronectin 1	Homo sapiens	51-62
7594817-2	1995	A-7 was found to contain a mutant p53 gene in which the arginine codon at position 175 was substituted by a histidine codon.	Arginine	56-64	tumor protein p53	Homo sapiens	34-37
7650066-3	1995	A seven residue peptide containing residues 368-374, Val Tyr Tyr Val Gly Arg Lys, was demonstrated to be capable of inducing chemotactic migration of human peripheral blood neutrophils, monocytes, monocyte leukemia cell line THP-1, and infant foreskin fibroblasts.	Arginine	73-76	GLI family zinc finger 2	Homo sapiens	225-230
7544348-3	1995	It is synthesized in several different tissues from L-Arg and O2, using NADPH as an electron donor, by a family of heme-containing catalytically self-sufficient monooxygenases known as nitric oxide synthases (NOS).	Arginine	52-57	nitric oxide synthase 2	Homo sapiens	185-207
8674818-7	1995	Structural analysis showed that the granule form of the enzyme had an N-terminal amino acid sequence beginning at residue 42 of rat CPH, thereby implicating cleavage of the precursor after the fourth Arg in a site containing five consecutive Arg residues.	Arginine	200-203	carboxypeptidase E	Rattus norvegicus	132-135
7642961-1	1995	The immunocytochemical application of a monoclonal antibody (MAb) against the Arg-Arg region at the junction of the C-peptide and the insulin beta-chain of the human proinsulin molecule on rat pancreatic tissue resulted in positive immunogold labeling over the insulin- as well as the glucagon-secreting cells.	Arginine	78-81	insulin	Homo sapiens	166-176
7642961-1	1995	The immunocytochemical application of a monoclonal antibody (MAb) against the Arg-Arg region at the junction of the C-peptide and the insulin beta-chain of the human proinsulin molecule on rat pancreatic tissue resulted in positive immunogold labeling over the insulin- as well as the glucagon-secreting cells.	Arginine	82-85	insulin	Homo sapiens	166-176
7642961-5	1995	Examination of the amino acid sequences of proinsulin and proglucagon has shown that both molecules display this Arg-Arg dipeptide sequence, which could explain the labeling obtained on both cell types.	Arginine	113-116	insulin	Homo sapiens	43-53
7642961-5	1995	Examination of the amino acid sequences of proinsulin and proglucagon has shown that both molecules display this Arg-Arg dipeptide sequence, which could explain the labeling obtained on both cell types.	Arginine	117-120	insulin	Homo sapiens	43-53
8674818-7	1995	Structural analysis showed that the granule form of the enzyme had an N-terminal amino acid sequence beginning at residue 42 of rat CPH, thereby implicating cleavage of the precursor after the fourth Arg in a site containing five consecutive Arg residues.	Arginine	242-245	carboxypeptidase E	Rattus norvegicus	132-135
7627718-5	1995	Of these, monoclonal antibody 4G3, which recognizes an arginine-containing epitope in apoB, was the most effective in reducing LDL binding.	Arginine	55-63	apolipoprotein B	Homo sapiens	86-90
7627952-4	1995	Here we show that mAb PAb421 when microinjected into human SW480 colorectal carcinoma cells restores the transcription activation function to the resident mutant p53 (arg to his 273, pro to ser 309).	Arginine	167-170	tumor protein p53	Homo sapiens	162-165
7642616-3	1995	Substitution of arginine 70 in thrombin exosite I with glutamic acid effectively eliminated binding of the prototype thrombin aptamer.	Arginine	16-24	coagulation factor II, thrombin	Homo sapiens	31-39
7642616-3	1995	Substitution of arginine 70 in thrombin exosite I with glutamic acid effectively eliminated binding of the prototype thrombin aptamer.	Arginine	16-24	coagulation factor II, thrombin	Homo sapiens	117-125
7544123-5	1995	These results suggest that holo-transferrin activates expression of iNOS mRNA in rat aortic smooth muscle cells accompanied by nitric oxide accumulation via a pathway dependent on L-arginine in the culture medium.	Arginine	180-190	transferrin	Rattus norvegicus	32-43
7544123-5	1995	These results suggest that holo-transferrin activates expression of iNOS mRNA in rat aortic smooth muscle cells accompanied by nitric oxide accumulation via a pathway dependent on L-arginine in the culture medium.	Arginine	180-190	nitric oxide synthase 2	Rattus norvegicus	68-72
7630644-10	1995	It involved a C to G substitution in codon 93 of p16 and is predicted to change a threonine into an arginine.	Arginine	100-108	cyclin dependent kinase inhibitor 2A	Homo sapiens	49-52
7627691-1	1995	The apoB arginine-to glutamine change at codon 3500 has become established as a cause of failure of binding of the LDL particle to its receptor and the consequent hypercholesterolemia of familial defective apoB 100.	Arginine	9-17	apolipoprotein B	Homo sapiens	4-8
7627691-1	1995	The apoB arginine-to glutamine change at codon 3500 has become established as a cause of failure of binding of the LDL particle to its receptor and the consequent hypercholesterolemia of familial defective apoB 100.	Arginine	9-17	apolipoprotein B	Homo sapiens	206-214
7627691-7	1995	We conclude that this arginine 3500 is essential to the function of apoB and that its loss and replacement by glutamine or tryptophan is responsible for the hypercholesterolemia of familial defective apoB 100.	Arginine	22-30	apolipoprotein B	Homo sapiens	68-72
7627691-7	1995	We conclude that this arginine 3500 is essential to the function of apoB and that its loss and replacement by glutamine or tryptophan is responsible for the hypercholesterolemia of familial defective apoB 100.	Arginine	22-30	apolipoprotein B	Homo sapiens	200-208
7582980-0	1995	Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.	Arginine	62-70	coagulation factor II, thrombin	Homo sapiens	44-52
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Arginine	49-57	interleukin 1 beta	Homo sapiens	186-204
7620154-2	1995	A C-->T transition and a G-->A transition, both at the codon for arginine 611 of the mature vWF subunit, were found.	Arginine	65-73	von Willebrand factor	Homo sapiens	92-95
7628352-4	1995	It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations.	Arginine	210-218	interferon gamma	Homo sapiens	43-59
7628352-4	1995	It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations.	Arginine	210-218	interferon gamma	Homo sapiens	61-70
7628352-4	1995	It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations.	Arginine	285-293	interferon gamma	Homo sapiens	43-59
7628352-4	1995	It has been shown in other cell types that interferon-gamma (IFN gamma) and bacterial lipopolysaccharide induce the enzyme argininosuccinate synthetase (AS), enhancing the capacity of these cells to regenerate arginine from citrulline and maintain NO production in the presence of low arginine concentrations.	Arginine	285-293	interferon gamma	Homo sapiens	61-70
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Arginine	195-203	interleukin 1 beta	Rattus norvegicus	33-42
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Arginine	195-203	interleukin 1 beta	Homo sapiens	99-108
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Arginine	195-203	tumor necrosis factor	Homo sapiens	110-137
7628352-9	1995	Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO.	Arginine	195-203	interferon gamma	Homo sapiens	143-152
7628398-1	1995	Blockade of nitric oxide (NO) formation with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME) produces a dramatic increase in ACTH released by the iv injection of interleukin-1 beta (IL-1 beta).	Arginine	49-57	interleukin 1 beta	Homo sapiens	206-215
7615197-7	1995	L-arginine reversed the antisecretory effect of L-NMA on IL-1 beta-induced hypersecretion but did not modify the IL-1 beta-induced hypersecretion.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	57-66
7664797-4	1995	This automodification of RT6.2 is covalent, requires intact NAD as substrate, and displays characteristics typical for linkage of ADP-ribose to arginine.	Arginine	144-152	ADP-ribosyltransferase 2b	Rattus norvegicus	25-30
7664797-5	1995	The alloantigens RT6.1 and RT6.2 differ in ten amino acids, RT6.2 having two arginine residues not present in RT6.1.	Arginine	77-85	ADP-ribosyltransferase 2b	Rattus norvegicus	60-65
7559095-2	1995	The wild-type p53 gene has a polymorphism at codon 72 that presents the arginine (CGC) or proline (CCC) genotype, which recently has been reported to be associated with genetically determined susceptibility to smoking-related lung cancers.	Arginine	72-80	tumor protein p53	Homo sapiens	14-17
7479680-0	1995	Effects of arginine on the secretion of insulin and islet amyloid polypeptide in humans.	Arginine	11-19	insulin	Homo sapiens	40-47
7479680-5	1995	The insulin response to arginine was 426 +/- 84 pM (p &lt; 0.001), whereas the IAPP response was 4.9 +/- 1.8 pM (p &lt; 0.01) (r = 0.93, p &lt; 0.001).	Arginine	24-32	insulin	Homo sapiens	4-11
7479680-9	1995	Thus, the ratios of the insulin/IAPP responses to arginine were the same regardless of the glucose level, and the insulin and IAPP responses to arginine were highly correlated with each other at all glucose levels.	Arginine	144-152	insulin	Homo sapiens	114-121
7622471-6	1995	The C-terminal peptide contains only two basic residues, a Lys and an Arg (assumed to be analogous to Lys68 and Arg74 of hC5a), which could act as counter-ions for Glu199 of the receptor.	Arginine	70-73	complement C5a receptor 1	Homo sapiens	121-125
7622471-9	1995	Furthermore, the equivalent C-terminal peptide to hC5a des-Arg74 (i.e. lacking the C-terminal Arg) could partially activate the wild type but not the mutant receptor, whereas the converse peptide, containing Arg but containing Met instead of Lys, had equal potencies for both wild type and mutant receptors.	Arginine	59-62	complement C5a receptor 1	Homo sapiens	50-54
7622471-9	1995	Furthermore, the equivalent C-terminal peptide to hC5a des-Arg74 (i.e. lacking the C-terminal Arg) could partially activate the wild type but not the mutant receptor, whereas the converse peptide, containing Arg but containing Met instead of Lys, had equal potencies for both wild type and mutant receptors.	Arginine	94-97	complement C5a receptor 1	Homo sapiens	50-54
7608189-8	1995	An active site cysteine residue (Cys246; site of formation of persulfide in catalysis) and an arginine residue (Arg185; substrate binding site) in rhodanese were also conserved in MST.	Arginine	94-102	thiosulfate sulfurtransferase	Rattus norvegicus	147-156
7543491-8	1995	NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines.	Arginine	28-32	tumor necrosis factor	Homo sapiens	87-96
7543491-8	1995	NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines.	Arginine	28-32	interferon gamma	Homo sapiens	122-131
7543491-8	1995	NG-Monomethyl-L-arginine (MM-Arg), an NOS inhibitor, partially reversed the effects of TNF-alpha and, to a lesser extent, IFN-gamma in methylcellulose culture of total BM and CD34+ cells, and inhibited apoptosis of BM cells induced by these cytokines.	Arginine	28-32	CD34 molecule	Homo sapiens	175-179
7543703-3	1995	Pulmonary iNOS activity was measured by quantitating the conversion of L-arginine (L-Arg) to L-citrulline.	Arginine	71-81	nitric oxide synthase 2	Rattus norvegicus	10-14
7543703-3	1995	Pulmonary iNOS activity was measured by quantitating the conversion of L-arginine (L-Arg) to L-citrulline.	Arginine	83-88	nitric oxide synthase 2	Rattus norvegicus	10-14
7626659-9	1995	Both normal fibronectin and fibronectin in which canavanine replaced arginine were stable for 20 h in cells treated with brefeldin A or monensin.	Arginine	69-77	fibronectin 1	Homo sapiens	28-39
7622459-5	1995	Purified myeloperoxidase in combination with hydrogen peroxide and chloride, as well as stimulated human neutrophils, chlorinated tyrosine in the peptide Gly-Gly-Tyr-Arg.	Arginine	166-169	myeloperoxidase	Homo sapiens	9-24
7608153-0	1995	Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.	Arginine	0-8	complement C5a receptor 1	Homo sapiens	20-32
7612630-2	1995	Previous studies have demonstrated that TAR RNA contains a specific arginine binding pocket.	Arginine	68-76	RNA binding motif protein 8A	Homo sapiens	40-43
7599138-2	1995	Wild-type carbonic anhydrase III has an arginine at this position with the C alpha of residue 67 about 9.4 A from the zinc.	Arginine	40-48	carbonic anhydrase 3	Homo sapiens	10-32
7631779-0	1995	Arginine enhances glycogen synthesis in response to insulin in 3T3-L1 adipocytes.	Arginine	0-8	insulin	Homo sapiens	52-59
7631779-3	1995	L-Glutamate (L-Glu), a major metabolite of L-Arg, also enhanced insulin-stimulated glycogen synthesis.	Arginine	43-48	insulin	Homo sapiens	64-71
7631779-6	1995	The stimulatory effect of L-Arg on insulin-stimulated glycogen synthesis did not appear to be accounted for by the generation of polyamines or the production of nitric oxide, both potentially derived from the enzymatic conversion of L-Arg.	Arginine	26-31	insulin	Homo sapiens	35-42
7631779-6	1995	The stimulatory effect of L-Arg on insulin-stimulated glycogen synthesis did not appear to be accounted for by the generation of polyamines or the production of nitric oxide, both potentially derived from the enzymatic conversion of L-Arg.	Arginine	233-238	insulin	Homo sapiens	35-42
7631779-7	1995	In the presence of insulin, cellular ATP levels were significantly increased by L-Arg, L-Glu, and L-Lys as well.	Arginine	80-85	insulin	Homo sapiens	19-26
7631779-8	1995	These data suggest that metabolic degradation of L-Arg not related to citric acid cycle activity is important in the mechanism by which L-Arg enhances insulin-stimulated glycogen synthesis.	Arginine	49-54	insulin	Homo sapiens	151-158
7631779-8	1995	These data suggest that metabolic degradation of L-Arg not related to citric acid cycle activity is important in the mechanism by which L-Arg enhances insulin-stimulated glycogen synthesis.	Arginine	136-141	insulin	Homo sapiens	151-158
7619077-0	1995	Study of the roles of Arg-104 and Arg-225 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by site-directed mutagenesis.	Arginine	22-25	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	68-120
7619077-0	1995	Study of the roles of Arg-104 and Arg-225 in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by site-directed mutagenesis.	Arginine	34-37	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	68-120
7540515-1	1995	Inducible nitric oxide synthase (iNOS) catalyzes the formation of nitric oxide (NO) from L-arginine and O2.	Arginine	89-99	nitric oxide synthase 2	Rattus norvegicus	0-31
7540515-1	1995	Inducible nitric oxide synthase (iNOS) catalyzes the formation of nitric oxide (NO) from L-arginine and O2.	Arginine	89-99	nitric oxide synthase 2	Rattus norvegicus	33-37
7540573-6	1995	Recombinant rat islet iNOS was transiently and stably expressed in human kidney 293 fibroblasts, and the high enzymatic activity was inhibited by addition of the L-arginine analogs, N omega-nitro-L-arginine methyl ester and aminoguanidine.	Arginine	162-172	nitric oxide synthase 2	Rattus norvegicus	22-26
7621595-6	1995	Similarly, nearly half of the lpr sequences had arginines, an amino acid which promotes binding to dsDNA and is seldom observed in normal junctions.	Arginine	48-57	Fas (TNF receptor superfamily member 6)	Mus musculus	30-33
8537149-1	1995	Inducible nitric oxide synthase (iNOS), which catalyzes the reaction of L-arginine to L-citrulline and nitric oxide (NO), plays an important role in immune-mediated cardiac disorders.	Arginine	72-82	nitric oxide synthase 2	Homo sapiens	0-31
8537149-1	1995	Inducible nitric oxide synthase (iNOS), which catalyzes the reaction of L-arginine to L-citrulline and nitric oxide (NO), plays an important role in immune-mediated cardiac disorders.	Arginine	72-82	nitric oxide synthase 2	Homo sapiens	33-37
8537329-6	1995	Since rHPC was found to be stable both in milk and after purification, it is possible that these new cleavages on the amino side of arginine at dipeptide sites Lys-2-Arg-1, Lys151-Arg152, and Lys156-Arg157 could have occurred in the mammary gland.	Arginine	132-140	arginase 1	Sus scrofa	166-171
7541949-8	1995	The cilia stimulatory effects of TNF-alpha or IL-1 beta were inhibited by NG-monomethyl-L-arginine, a competitive NOS inhibitor, and restored by the addition of either L-arginine, an NOS substrate, or sodium nitroprusside, an NO donor.	Arginine	88-98	tumor necrosis factor	Homo sapiens	33-42
7478791-2	1995	The terminal guanidino N-atom of L-arginine is the precursor for NO, which is oxidized to the stable inorganic nitrogen oxides, nitrite (NO2-) and nitrate (NO3-).	Arginine	33-43	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
7797466-0	1995	Cleavage at arginine 145 in human blood coagulation factor IX converts the zymogen into a factor VIII binding enzyme.	Arginine	12-20	coagulation factor IX	Homo sapiens	40-61
15714750-5	1995	Preincubation of endothelial cells with bradykinin and superoxide dismutase (SOD) synergistically potentiated the increase in platelet cGMP, but was attenuated by Nomega-nitro-L-arginine, with partial restoration by L-arginine but not by D-arginine.	Arginine	176-186	kininogen 1	Homo sapiens	40-50
7579540-0	1995	Relationship between insulin responses to D-glucose and to L-arginine in women with a history of gestational diabetes.	Arginine	59-69	insulin	Homo sapiens	21-28
7579540-1	1995	The relationship between insulin responses to glucose and to arginine was studied in non-obese women with previous gestational diabetes (PGD).	Arginine	61-69	insulin	Homo sapiens	25-32
7615784-7	1995	In the presence of L-arginine, but not D-arginine, IL-1 beta, an inducer of inducible NO synthase, also inhibited AII-induced SMC migration, and this effect was prevented by the NO-synthase inhibitor, N-nitro-L-arginine methyl ester.	Arginine	19-29	interleukin 1 beta	Rattus norvegicus	51-60
7615784-7	1995	In the presence of L-arginine, but not D-arginine, IL-1 beta, an inducer of inducible NO synthase, also inhibited AII-induced SMC migration, and this effect was prevented by the NO-synthase inhibitor, N-nitro-L-arginine methyl ester.	Arginine	19-29	nitric oxide synthase 2	Rattus norvegicus	76-97
7615784-7	1995	In the presence of L-arginine, but not D-arginine, IL-1 beta, an inducer of inducible NO synthase, also inhibited AII-induced SMC migration, and this effect was prevented by the NO-synthase inhibitor, N-nitro-L-arginine methyl ester.	Arginine	19-29	angiotensinogen	Rattus norvegicus	114-117
7616106-0	1995	Binding of Gc globulin (vitamin D binding protein) to C5a or C5a des Arg is not necessary for co-chemotactic activity.	Arginine	69-72	complement C5a receptor 1	Homo sapiens	61-64
7616106-1	1995	Gc globulin (vitamin D binding protein) has been shown to augment significantly the leukocyte chemotactic activity of the activated complement peptides C5a and C5a des Arg.	Arginine	168-171	complement C5a receptor 1	Homo sapiens	160-163
7616106-6	1995	The dose-response curves of neutrophil chemotaxis to recombinant C5a or C5a des Arg plus Gc globulin were identical to those observed with the naturally derived peptides, despite the fact that natural C5a bound to Gc globulin while the recombinant C5a failed to bind this protein.	Arginine	80-83	complement C5a receptor 1	Homo sapiens	72-75
7616106-6	1995	The dose-response curves of neutrophil chemotaxis to recombinant C5a or C5a des Arg plus Gc globulin were identical to those observed with the naturally derived peptides, despite the fact that natural C5a bound to Gc globulin while the recombinant C5a failed to bind this protein.	Arginine	80-83	complement C5a receptor 1	Homo sapiens	72-75
7616106-6	1995	The dose-response curves of neutrophil chemotaxis to recombinant C5a or C5a des Arg plus Gc globulin were identical to those observed with the naturally derived peptides, despite the fact that natural C5a bound to Gc globulin while the recombinant C5a failed to bind this protein.	Arginine	80-83	complement C5a receptor 1	Homo sapiens	72-75
7616106-8	1995	These results indicate that the binding of C5a/C5a des Arg to Gc globulin is not necessary for their chemotactic activity to be augmented.	Arginine	55-58	complement C5a receptor 1	Homo sapiens	47-50
7616384-4	1995	Similar relaxations to L-arginine were seen in rings of thoracic and abdominal aorta from rats made hypertensive by infusion of angiotensin II for 7 to 8 days but not in rings of thoracic aorta from rats with aortic coarctation-induced hypertension of 28 to 42 days.	Arginine	23-33	angiotensinogen	Rattus norvegicus	128-142
7616384-6	1995	Our results suggest that the vasorelaxant effects of L-arginine in aortic rings from hypertensive rats 7 to 14 days after aortic coarctation and 7 to 8 days after commencing angiotensin II infusion are mediated by nitric oxide.	Arginine	53-63	angiotensinogen	Rattus norvegicus	174-188
7797592-3	1995	Both were highly homologous to human ICE (52% identical) and CED-3 (25% identical) and both contained the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp containing the catalytic cysteine residue.	Arginine	161-164	caspase 1	Homo sapiens	37-40
7541949-8	1995	The cilia stimulatory effects of TNF-alpha or IL-1 beta were inhibited by NG-monomethyl-L-arginine, a competitive NOS inhibitor, and restored by the addition of either L-arginine, an NOS substrate, or sodium nitroprusside, an NO donor.	Arginine	88-98	interleukin 1 beta	Homo sapiens	46-55
7539409-2	1995	In this study, the role of the sulfhydryl groups in defining the antibacterial and histamine-releasing activities of the active fragments of GNCP-1 (Arg-1 to Tyr-14 [Arg-1-Tyr-14] and Arg-15-Tyr-27 peptides) was examined by using peptides containing alkylated or nonalkylated sulfhydryl groups.	Arginine	166-169	arginase-1	Cavia porcellus	161-164
8521249-1	1995	Cold exposure significantly decreased the insulin response to the intravenous injection of arginine, butyrate and tolbutamide, and tended to reduce the response to glucose in goats.	Arginine	91-99	insulin	Capra hircus	42-49
7788012-0	1995	Growth hormone response to growth hormone-releasing hormone (GHRH), insulin, clonidine and arginine after GHRH pretreatment in obese children: evidence of somatostatin increase?	Arginine	91-99	growth hormone 1	Homo sapiens	0-14
7546624-1	1995	Nitric oxide (NO), synthesized from L-arginine by a family of NO synthases (NOS), is a widespread biological mediator implicated in many physiological and pathophysiological processes, including a variety of cardiovascular diseases.	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	62-74
7546628-2	1995	Abundant evidence is now available that NO, synthesized from L-arginine by NO synthase (NOS), is a nonadrenergic noncholinergic relaxant transmitter of gastrointestinal smooth muscle.	Arginine	61-71	nitric oxide synthase 2	Homo sapiens	75-86
7546631-3	1995	NO levels of target tissues can be affected directly by NO donors, or indirectly by increasing the level of L-arginine, a substrate of nitric oxide synthase (NOS).	Arginine	108-118	nitric oxide synthase 2	Homo sapiens	135-156
7477728-6	1995	Two rare mutations were found in the EVI2A gene, one resulting in an arginine substituting for a glutamine (one control and one patient), the other in the replacement of a glycine with serine (one control only).	Arginine	69-77	ecotropic viral integration site 2A	Homo sapiens	37-42
7775622-3	1995	Arginine was injected intravenously (5 g), which rapidly stimulated insulin and glucagon secretion in all subjects.	Arginine	0-8	insulin	Homo sapiens	68-75
7775622-5	1995	The acute insulin response to arginine (AIR = 2-5 min postload increase) at BG 14 mmol/L, but not at fasting BG or BG 28 mmol/L, was lower in IGT than in NGT (P = 0.033), as was the glucose potentiation of AIR (slopeAIR) (P = 0.020).	Arginine	30-38	insulin	Homo sapiens	10-17
7662997-4	1995	By molecular analysis of the EC-SOD coding region from the group II individuals in Sweden, a single nucleotide substitution of G to C generating an amino acid change of arginine to glycine has been identified in the region associated with the heparin affinity of the enzyme.	Arginine	169-177	superoxide dismutase 3	Homo sapiens	29-35
7544846-4	1995	Nitric oxide is synthesized from a L-arginine by the cytoplasmic enzyme nitric oxide synthase (NOS) which is a calcium dependent enzyme, and this pathway is inhibited by the analogues of L-arginine such as NG-monomethyl-L-arginine (L-NMMA) and is augmented by NMDA receptor activation.	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	72-93
7544846-4	1995	Nitric oxide is synthesized from a L-arginine by the cytoplasmic enzyme nitric oxide synthase (NOS) which is a calcium dependent enzyme, and this pathway is inhibited by the analogues of L-arginine such as NG-monomethyl-L-arginine (L-NMMA) and is augmented by NMDA receptor activation.	Arginine	187-197	nitric oxide synthase 2	Homo sapiens	72-93
7753841-6	1995	However, restriction of dietary L-arginine intake, even when total protein intake was normal, resulted in decreased proteinuria, decreased expression of TGF-beta 1 mRNA and TGF-beta 1 protein, and decreased production and deposition of matrix components.	Arginine	32-42	transforming growth factor, beta 1	Rattus norvegicus	153-163
7605578-3	1995	This p53 mutation resulted in the same change, an Arg--&gt;Ser substitution, as in the human p53 gene at position 249.	Arginine	50-53	tumor protein p53	Homo sapiens	93-96
8592522-6	1995	Because the ADP ribosylation of FGF-2 is acid resistant but base and hydroxylamine sensitive, the linkage appears to be mediated through arginine.	Arginine	137-145	fibroblast growth factor 2	Homo sapiens	32-37
7744836-1	1995	Recombinant alpha 1-antitrypsin with a P1 arginine residue (Arg-alpha 1-antitrypsin) is a rapid inhibitor of both thrombin and activated protein C (APC).	Arginine	42-50	serpin family A member 1	Homo sapiens	12-31
7744836-1	1995	Recombinant alpha 1-antitrypsin with a P1 arginine residue (Arg-alpha 1-antitrypsin) is a rapid inhibitor of both thrombin and activated protein C (APC).	Arginine	42-50	serpin family A member 1	Homo sapiens	64-83
7744836-1	1995	Recombinant alpha 1-antitrypsin with a P1 arginine residue (Arg-alpha 1-antitrypsin) is a rapid inhibitor of both thrombin and activated protein C (APC).	Arginine	42-50	coagulation factor II, thrombin	Homo sapiens	114-122
7752183-4	1995	Since the 400-411 sequence is required for gamma-chain bioactivity and is a unique recognition sequence among ligands for integrins, vis-a-vis other RGD (Arg-Gly-Asp)-presenting proteins, these turn mimetics may represent a new, selective approach to antagonism of the fibrinogen receptor.	Arginine	154-157	fibrinogen beta chain	Homo sapiens	269-279
7605578-1	1995	A mutation in the tumor suppressor p53 gene resulting in an Arg--&gt;Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure.	Arginine	60-63	tumor protein p53	Homo sapiens	35-38
7605578-3	1995	This p53 mutation resulted in the same change, an Arg--&gt;Ser substitution, as in the human p53 gene at position 249.	Arginine	50-53	tumor protein p53	Homo sapiens	5-8
7539253-8	1995	These observations indicate that co-induction of iNOS and AII occurs by distinct transcriptional mechanisms, AII induction could diminish NO production by decreasing L-arginine availability, and IFN-gamma can prevent AII induction.	Arginine	166-176	nitric oxide synthase 2, inducible	Mus musculus	49-53
7744733-5	1995	A triple mutation, Asn-Asp-Gly-Gly instead of Arg-His-Gly-Arg, completely abolishes the capacity of the peptide P-(145-159) to elute AChE from the heparin column.	Arginine	58-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	133-137
7538671-1	1995	In inflammatory states, nitric oxide (.NO) may be synthesized from precursor L-arginine via inducible .NO synthase (iNOS) in large amounts for prolonged periods of time.	Arginine	77-87	nitric oxide synthase 2, inducible	Mus musculus	92-114
7538671-1	1995	In inflammatory states, nitric oxide (.NO) may be synthesized from precursor L-arginine via inducible .NO synthase (iNOS) in large amounts for prolonged periods of time.	Arginine	77-87	nitric oxide synthase 2, inducible	Mus musculus	116-120
7753841-6	1995	However, restriction of dietary L-arginine intake, even when total protein intake was normal, resulted in decreased proteinuria, decreased expression of TGF-beta 1 mRNA and TGF-beta 1 protein, and decreased production and deposition of matrix components.	Arginine	32-42	transforming growth factor, beta 1	Rattus norvegicus	173-183
7771524-8	1995	Similarly, addition of L-arginine (0.7 mM) to the bath reduced renin secretion from 0.99 +/- 0.37 to 0.81 +/- 0.38 log nGU/min (P &lt; 0.01), whereas addition of L-arginine to the luminal fluid increased renin secretion from 0.85 +/- 0.43 to 1.94 +/- 0.46 log nGU/min (P &lt; 0.05).	Arginine	23-33	renin	Homo sapiens	63-68
7538287-0	1995	TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. OBJECTIVE: The authors determined the endothelial arginine transport mechanism and the potential role of a tumor necrosis factor (TNF)-alpha-mediated signal transduction pathway involving protein kinase C (PKC) in regulating this transport in cultured endothelial cells.	Arginine	15-23	tumor necrosis factor	Homo sapiens	0-3
7741742-4	1995	The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide.	Arginine	187-195	msh homeobox 2	Homo sapiens	116-119
7539586-1	1995	Nitric oxide (NO) is generated from L-arginine by NO synthase (NOS).	Arginine	36-46	nitric oxide synthase 2	Homo sapiens	50-61
7771573-10	1995	Overall these results suggest that L-arginine analogues attenuate aldosterone secretion by inhibiting the adrenal steroidogenic effects of endogenous or exogenous angiotensin II and/or by reducing plasma levels of renin/angiotensin.	Arginine	35-45	angiotensinogen	Rattus norvegicus	163-177
7538287-0	1995	TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. OBJECTIVE: The authors determined the endothelial arginine transport mechanism and the potential role of a tumor necrosis factor (TNF)-alpha-mediated signal transduction pathway involving protein kinase C (PKC) in regulating this transport in cultured endothelial cells.	Arginine	15-23	tumor necrosis factor	Homo sapiens	212-245
7538287-0	1995	TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. OBJECTIVE: The authors determined the endothelial arginine transport mechanism and the potential role of a tumor necrosis factor (TNF)-alpha-mediated signal transduction pathway involving protein kinase C (PKC) in regulating this transport in cultured endothelial cells.	Arginine	155-163	tumor necrosis factor	Homo sapiens	0-3
7538287-3	1995	METHODS: Arginine transport was assayed in confluent human umbilical vein endothelial cells in the presence of TNF +/- the PKC inhibitor chelerythrine chloride.	Arginine	9-17	tumor necrosis factor	Homo sapiens	111-114
7771524-8	1995	Similarly, addition of L-arginine (0.7 mM) to the bath reduced renin secretion from 0.99 +/- 0.37 to 0.81 +/- 0.38 log nGU/min (P &lt; 0.01), whereas addition of L-arginine to the luminal fluid increased renin secretion from 0.85 +/- 0.43 to 1.94 +/- 0.46 log nGU/min (P &lt; 0.05).	Arginine	23-33	renin	Homo sapiens	204-209
7538287-5	1995	Tumor necrosis factor (0.1-2 ng/mL) increased System y(+)-mediated arginine transport in a time- and dose-dependent manner by augmenting System y+ transport maximal capacity (control Vmax = 1325 +/- 60 pmol/mg protein/minute vs. TNF Vmax = 3015 +/- 110 pmol/mg protein/minute, p &lt; 0.01) without affecting transporter affinity (control Km = 30 +/- 1.4 microM vs. 34 +/- 1.3 microM arginine, p = NS).	Arginine	67-75	tumor necrosis factor	Homo sapiens	0-21
7538287-5	1995	Tumor necrosis factor (0.1-2 ng/mL) increased System y(+)-mediated arginine transport in a time- and dose-dependent manner by augmenting System y+ transport maximal capacity (control Vmax = 1325 +/- 60 pmol/mg protein/minute vs. TNF Vmax = 3015 +/- 110 pmol/mg protein/minute, p &lt; 0.01) without affecting transporter affinity (control Km = 30 +/- 1.4 microM vs. 34 +/- 1.3 microM arginine, p = NS).	Arginine	383-391	tumor necrosis factor	Homo sapiens	0-21
7542073-3	1995	iNOS generates the gas nitric oxide from L-arginine, and elevated levels of NO in exhaled air have been described in asthma.	Arginine	41-51	nitric oxide synthase 2	Homo sapiens	0-4
7538287-7	1995	In addition, inhibition of PKC with chelerythrine abrogated the TNF-augmented arginine transport.	Arginine	78-86	tumor necrosis factor	Homo sapiens	64-67
7654933-10	1995	It also suggests that the change Arg-->Cys produces more severe alterations in the functions of fibrinogen than the substitution Arg-->His.	Arginine	33-36	fibrinogen beta chain	Homo sapiens	96-106
7664177-1	1995	In a number of mammalian cell types, pteridine biosynthesis from guanosine 5"-triphosphate and formation of nitric oxide from L-arginine are induced by gamma interferon (IFN-gamma) and bacterial lipopolysaccharide (LPS).	Arginine	126-136	interferon gamma	Homo sapiens	152-179
7656186-2	1995	Both enzymes were kallikrein-like and were bound by diisopropylfluorophosphate; had pH optima from 9 to 10; showed high specificity for the hydrolysis of arginine peptide bonds and low to moderate affinity for lysine bonds at the P1 substrate recognition sites; were inhibited by aprotinin, benzamidine, leupeptin, and soybean trypsin inhibitor; generated kinin from kininogen and were highly stable at room temperature.	Arginine	154-162	kunitz trypsin protease inhibitor	Glycine max	327-344
7536666-5	1995	As expected NO synthesis was 1) dependent upon the presence of L-arginine in the extracellular medium, 2) subject to significant stimulation by Nw-hydroxy-L-arginine, an L-arginine-derived intermediate in NO biosynthesis, and by sodium nitroprusside, a non-L-arginine-dependent source of intracellular NO, and 3) inhibited by Nw-nitro-L-arginine methyl ester, a competitive inhibitor of iNOS.	Arginine	155-165	nitric oxide synthase 2	Gallus gallus	387-391
7536666-5	1995	As expected NO synthesis was 1) dependent upon the presence of L-arginine in the extracellular medium, 2) subject to significant stimulation by Nw-hydroxy-L-arginine, an L-arginine-derived intermediate in NO biosynthesis, and by sodium nitroprusside, a non-L-arginine-dependent source of intracellular NO, and 3) inhibited by Nw-nitro-L-arginine methyl ester, a competitive inhibitor of iNOS.	Arginine	155-165	nitric oxide synthase 2	Gallus gallus	387-391
7612412-13	1995	Seronegative (prognostically good) and seropositive (prognostically worse) patients can be distinguished by the arginine versus lysine substitution at position 71 of the HLA-DRB1 gene.	Arginine	112-120	major histocompatibility complex, class II, DR beta 1	Homo sapiens	170-178
7622024-1	1995	The effect of the expression of the exogenous human mutant p53 (Arg--&gt;His in codon 273) on the amplification rate of the gene dhfr in permissive Rat-1 and LIM1215 cells was studied.	Arginine	64-67	tumor protein p53	Homo sapiens	59-62
18406692-1	1995	The melanocortins (MCs), that is, the melanocyte-stimulating hormones (MSHs) and ACTH, are a group of related peptides containing the typical melanotropin core sequence, His-Phe-Arg-Trp, and are derived from a common precursor, pro-opiomelanocortin.	Arginine	178-181	proopiomelanocortin	Homo sapiens	81-85
7537754-4	1995	The inhibition of Na+/K(+)-ATPase activity by LPS/IFN gamma was prevented by simultaneous incubation with N omega-nitro L-arginine and markedly blunted by removal of L-arginine from the medium.	Arginine	120-130	toll-like receptor 4	Mus musculus	46-49
7537754-4	1995	The inhibition of Na+/K(+)-ATPase activity by LPS/IFN gamma was prevented by simultaneous incubation with N omega-nitro L-arginine and markedly blunted by removal of L-arginine from the medium.	Arginine	120-130	interferon gamma	Mus musculus	50-59
7738179-4	1995	Specifically, rheumatoid factor (RF) negative patients preferentially expressed RA-linked HLA-DRB1 alleles with an arginine substitution in position 71, whereas the alleles with a lysine substitution in position 71 accumulated in RF+ patients.	Arginine	115-123	major histocompatibility complex, class II, DR beta 1	Homo sapiens	90-98
7745022-6	1995	The only mutation that was identified was at codon 201 of Gs alpha (gsp), which encoded a change from arginine to cysteine.	Arginine	102-110	GNAS complex locus	Homo sapiens	58-66
7745022-6	1995	The only mutation that was identified was at codon 201 of Gs alpha (gsp), which encoded a change from arginine to cysteine.	Arginine	102-110	GNAS complex locus	Homo sapiens	68-71
7772676-2	1995	Nitric oxide can be synthesised from L-arginine by any of three isoforms of nitric oxide synthase (NOS), and its interaction with prostacyclin, its proposed mechanisms of action and cytotoxicity are briefly reviewed in the context of cardiovascular function.	Arginine	37-47	nitric oxide synthase 2	Homo sapiens	76-97
7752910-4	1995	Insulin secretion was stimulated by glucagon, arginine, and glucose on separate days.	Arginine	46-54	insulin	Homo sapiens	0-7
7739539-5	1995	Substitution of an atypical tyrosine in the basic region of ADD1/SREBP1 to an arginine found in most bHLH protein causes a restriction to only E-box binding.	Arginine	78-86	adducin 1	Homo sapiens	60-64
7739539-6	1995	Conversely, substitution of a tyrosine for the equivalent arginine in another bHLH protein, upstream stimulatory factor, allows this factor to acquire a dual binding specificity similar to that of ADD1/SREBP1.	Arginine	58-66	adducin 1	Homo sapiens	197-201
7739539-7	1995	Promoter activation by ADD1/SREBP1 through the carbohydrate response element E box is not sensitive to the tyrosine-to-arginine mutation, while activation through SRE-1 is completely suppressed.	Arginine	119-127	adducin 1	Homo sapiens	23-27
7536940-12	1995	If human AM generate NO from L-arginine by either iNOS or other NADPH oxidases then NO may play a role in the overall host-defense response of the lung to MAC and MTB.	Arginine	29-39	nitric oxide synthase 2	Homo sapiens	50-54
7544607-9	1995	But the activity increased in both fractions when supplemented with calcium/calmodulin: in membranes from about 40 to 110 fmol/min/mg of protein and in the cytosol from near zero to about 350 fmol/min/mg of protein in assays carried out at 0.3 microM L-arginine.	Arginine	251-261	calmodulin	Bos taurus	76-86
7731966-2	1995	Of five Sp alleles, Splotch-delayed (Spd) is the only one that encodes a full-length Pax-3 protein, containing a single glycine-to-arginine substitution within the paired domain.	Arginine	131-139	paired box 3	Mus musculus	20-27
7731966-2	1995	Of five Sp alleles, Splotch-delayed (Spd) is the only one that encodes a full-length Pax-3 protein, containing a single glycine-to-arginine substitution within the paired domain.	Arginine	131-139	paired box 3	Mus musculus	85-90
7711031-7	1995	The RYRs calmodulin binding site CaM1 encompasses the sequence Arg-His-Arg-Val(Ile)-Ser-Leu, which is phosphorylated in vitro by the catalytic subunit of the cAMP-dependent protein kinase.	Arginine	63-66	calmodulin 1	Homo sapiens	9-19
7784416-0	1995	[Detection of the Arg 3500--&gt;Gln mutation of B apolipoprotein.	Arginine	18-21	apolipoprotein E	Homo sapiens	50-64
7733665-9	1995	These data indicate that at least one arginine is important for calmodulin binding and is likely located at the calmodulin binding site of the CaN A subunit.	Arginine	38-46	calmodulin 1	Homo sapiens	64-74
7733665-9	1995	These data indicate that at least one arginine is important for calmodulin binding and is likely located at the calmodulin binding site of the CaN A subunit.	Arginine	38-46	calmodulin 1	Homo sapiens	112-122
7711031-7	1995	The RYRs calmodulin binding site CaM1 encompasses the sequence Arg-His-Arg-Val(Ile)-Ser-Leu, which is phosphorylated in vitro by the catalytic subunit of the cAMP-dependent protein kinase.	Arginine	71-74	calmodulin 1	Homo sapiens	9-19
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Arginine	165-168	calmodulin 1	Homo sapiens	39-49
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Arginine	165-168	ryanodine receptor 1	Homo sapiens	61-64
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Arginine	173-176	calmodulin 1	Homo sapiens	39-49
7711031-10	1995	These data indicate that the effect of calmodulin binding to RYR CaM1 may be regulated by the phosphorylation state of the Ser residue localized within the sequence Arg-His-Arg-Val(Ile)-Ser-Leu.	Arginine	173-176	ryanodine receptor 1	Homo sapiens	61-64
7721771-5	1995	We found that occupation of the lysine binding site of tPA by a lysine or arginine side chain from the urokinase moiety is responsible for the high temperature transition as well as for the failure of the chimeras to exhibit the expected fibrin binding properties.	Arginine	74-82	plasminogen activator, tissue type	Homo sapiens	55-58
7706743-12	1995	Lack of L-arginine in the medium resulted in a threefold increase in LPS-stimulated TNF synthesis compared with medium containing the usual concentration of 1 mM L-arginine.	Arginine	8-18	tumor necrosis factor	Mus musculus	84-87
7706743-13	1995	Restitution of L-arginine but not of D-arginine reversed this increase in TNF synthesis in a dose-dependent manner.	Arginine	15-25	tumor necrosis factor	Mus musculus	74-77
7718556-11	1995	In vitro, native disulfide bond formation improvement observed for KR-ET-1 could be ascribed to electrostatic interactions and more specifically to the Arg(-1)-Glu10 salt bridge.	Arginine	152-155	endothelin 1	Homo sapiens	70-74
7713870-4	1995	It could degrade VIP by cleaving three peptide bonds not containing an arginine residue(s) with Km = 7.7 x 10(-6) M and kcat/Km = 7.4 x 10(6) M-1 s-1 (at pH 7.6 in the presence of 0.1% Lubrol PX), whereas only secretin, substance P, and a few others were hydrolyzed at much slower rates among the various peptides examined.	Arginine	71-79	vasoactive intestinal peptide	Homo sapiens	17-20
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	95-98	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
7713946-5	1995	The current model for receptor activation by thrombin involves specific hydrolysis of the arginine-41/serine-42 (Arg-41/Ser-42) peptide bond.	Arginine	90-98	coagulation factor II, thrombin	Homo sapiens	45-53
7701349-1	1995	A single heterozygous nucleotide exchange in exon M2 of the gene encoding the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor was identified in a patient with Jansen-type metaphyseal chondrodysplasia, which changes a strictly conserved histidine residue at position 223 in the receptor"s first intracellular loop to arginine.	Arginine	345-353	parathyroid hormone 1 receptor	Homo sapiens	135-154
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	95-98	proprotein convertase subtilisin/kexin type 2	Bos taurus	10-13
7713946-5	1995	The current model for receptor activation by thrombin involves specific hydrolysis of the arginine-41/serine-42 (Arg-41/Ser-42) peptide bond.	Arginine	113-116	coagulation factor II, thrombin	Homo sapiens	45-53
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 2	Bos taurus	10-13
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 2	Bos taurus	10-13
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 1	Bos taurus	0-3
7713926-7	1995	PC1/3 and PC2 cleaved paired basic and monobasic sites within peptide-MCA substrates, with Boc-Arg-Val-Arg-Arg-MCA and pGlu-Arg-Thr-Lys-Arg-MCA as the most effectively cleaved peptides tested.	Arginine	103-106	proprotein convertase subtilisin/kexin type 2	Bos taurus	10-13
7698507-1	1995	Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide.	Arginine	72-82	interleukin 1 beta	Rattus norvegicus	0-18
7606201-6	1995	A striking difference in the distribution of the serine (WAF-ser) and arginine (WAF-arg) forms of WAF-1/CIP-1/p21 was observed when normal healthy Caucasians and Chinese were compared (P &lt; 0.0001).	Arginine	70-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-113
7633398-0	1995	Characterization of alternative amino acid substitutions at arginine 830 of the androgen receptor that cause complete androgen insensitivity in three families.	Arginine	60-68	androgen receptor	Homo sapiens	80-97
7698507-9	1995	Addition of nicotinamide and L-arginine depletion reduced the upregulation of 16 and 20 IL-1 beta-induced proteins, respectively.	Arginine	29-39	interleukin 1 beta	Rattus norvegicus	88-97
7633398-1	1995	We have studied two different missense mutations at arginine-830 in exon 7 of the human androgen receptor (hAR) gene that cause complete androgen insensitivity (CAIS) in three families.	Arginine	52-60	androgen receptor	Homo sapiens	88-105
7897227-6	1995	From the amino acid sequence of the dodecapeptide Gly-Ser-Val-Ser-Asp-Glu-Glu-Met-Met-Glu-Leu-Arg, the phosphorylation site of pp65 was located at the N-terminal region adjacent to the first Ca2+ binding domain.	Arginine	94-97	lymphocyte cytosolic protein 1	Mus musculus	127-131
7612920-8	1995	In normal subjects, the true and total insulin levels in the fasting state and at the time peak after glucose- or arginine-induced endogenous insulin release were well correlated at r = 0.88 and 0.89, respectively.	Arginine	114-122	insulin	Homo sapiens	39-46
7861463-6	1995	RESULTS: Both ER-negative and ER-positive tumors contained neutral polymorphisms in codons 10 [TCT--&gt;TCC (Ser)], 87 [GCG--&gt;GCC (Ala)], 243 [CGC--&gt;CGT (Arg)], 325 [CCC--&gt;CCG (Pro)], and 594 [ACA--&gt;ACG (Thr)].	Arginine	160-163	estrogen receptor 1	Homo sapiens	14-16
7861463-6	1995	RESULTS: Both ER-negative and ER-positive tumors contained neutral polymorphisms in codons 10 [TCT--&gt;TCC (Ser)], 87 [GCG--&gt;GCC (Ala)], 243 [CGC--&gt;CGT (Arg)], 325 [CCC--&gt;CCG (Pro)], and 594 [ACA--&gt;ACG (Thr)].	Arginine	160-163	estrogen receptor 1	Homo sapiens	30-32
7613468-4	1995	Loop I contains an arginine at position 11, which is found only in the fasciculins and could form a pivotal anchoring point to AChE.	Arginine	19-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
7896796-6	1995	The carboxyl-terminal incompatibility site was identified as residues 19-21 (Glu-Arg-Val in PTH and Arg-Arg-Arg in PTHrP); extending the amino-terminal PTHrP sequence to residue 21 but not to 18 cured the hybrid"s binding defect.	Arginine	81-84	parathyroid hormone	Rattus norvegicus	92-95
7893664-2	1995	The serpins antithrombin, protease nexin 1, and alpha 1-antitrypsin with a reactive-center arginine (Arg-alpha 1-antitrypsin) were found to inhibit the sperm protease acrosin with varying efficiency.	Arginine	91-99	serpin family A member 1	Homo sapiens	48-67
7893664-2	1995	The serpins antithrombin, protease nexin 1, and alpha 1-antitrypsin with a reactive-center arginine (Arg-alpha 1-antitrypsin) were found to inhibit the sperm protease acrosin with varying efficiency.	Arginine	91-99	serpin family A member 1	Homo sapiens	105-124
7533537-9	1995	Within domain 18-24, arginine 21 is required for inhibition of t-PA and alpha 2M* binding as well as for the direct binding of amino-terminal constructs to LRP.	Arginine	21-29	plasminogen activator, tissue type	Homo sapiens	63-67
7533537-9	1995	Within domain 18-24, arginine 21 is required for inhibition of t-PA and alpha 2M* binding as well as for the direct binding of amino-terminal constructs to LRP.	Arginine	21-29	LDL receptor related protein 1	Homo sapiens	156-159
17743549-6	1995	Similar agreement was obtained in initial studies that modeled experimental data for arginine-protonated bradykinin.	Arginine	85-93	kininogen 1	Homo sapiens	105-115
7535004-4	1995	Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production.	Arginine	140-150	interleukin 1 beta	Rattus norvegicus	31-49
7535004-4	1995	Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production.	Arginine	140-150	interleukin 1 beta	Rattus norvegicus	51-60
7535004-4	1995	Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production.	Arginine	140-150	tumor necrosis factor	Rattus norvegicus	66-93
7535004-4	1995	Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production.	Arginine	140-150	tumor necrosis factor	Rattus norvegicus	95-104
7612920-8	1995	In normal subjects, the true and total insulin levels in the fasting state and at the time peak after glucose- or arginine-induced endogenous insulin release were well correlated at r = 0.88 and 0.89, respectively.	Arginine	114-122	insulin	Homo sapiens	142-149
7538426-3	1995	Although ineffective by itself, LPL in combination with IFN-gamma increased L-arginine-dependent NO production in a dose-dependent manner.	Arginine	76-86	interferon gamma	Homo sapiens	56-65
7534807-5	1995	Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase.	Arginine	206-216	tumor necrosis factor	Homo sapiens	69-96
7540349-1	1995	Nitric oxide synthases (NOS) are enzymes that produce nitric oxide (NO) from L-arginine in a reaction yielding citrulline as a coproduct.	Arginine	77-87	nitric oxide synthase 2	Homo sapiens	0-22
7534807-3	1995	N omega-nitro-L-arginine, an inhibitor of NO synthase, potentiated thrombin-induced aggregation of washed human platelets, whereas L-arginine inhibited it.	Arginine	14-24	coagulation factor II, thrombin	Homo sapiens	67-75
21556589-4	1995	Sequencing of p53 cDNA revealed a mutation CGC(Arg)--&gt;CAC(His) at codon 175 of the gene encoding for an abundant nuclear protein.	Arginine	47-50	tumor protein p53	Homo sapiens	14-17
7534807-5	1995	Incubation of washed platelets in Ca(++)-free buffer with cytokines (tumor necrosis factor-alpha and interferon-gamma) or cytokines plus lipopolysaccharide caused a marked increase in the conversion of [3H]L-arginine to [3H]L-citrulline, suggesting the presence of inducible form of NO synthase.	Arginine	206-216	interferon gamma	Homo sapiens	101-117
7780824-1	1995	We investigated the effect of nitric oxide, derived from L-arginine on the production of endothelin-1 in vivo and in cultured endothelial cells.	Arginine	57-67	endothelin 1	Homo sapiens	89-101
8529105-6	1995	RESULTS: Expression of the transgene correlated with three Lshr-associated lipopolysaccharide/interferon-gamma-regulated macrophage activation phenotypes: respiratory burst, nitrite release, and uptake of L-arginine.	Arginine	205-215	interferon gamma	Mus musculus	94-110
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Arginine	165-168	angiotensinogen	Homo sapiens	135-149
7775978-2	1995	Potentiometric and spectroscopic (absorption, circular dichroism and electron paramagnetic resonance) study on the coordination of two angiotensin II fragments (Asp-Arg-Val-Tyr-Ile-His and Arg-Val-Tyr-Ile-His) to Cu(II) ions has shown that competition between amino and imidazole nitrogens to anchor metal ions is a complicated process and may lead to formation of macrochelate rings.	Arginine	189-192	angiotensinogen	Homo sapiens	135-149
7739167-4	1995	Addition of L-arginine, a substrate of EDRF/NO, after treatment with L-NNA reversed VIP-induced pulmonary vasodilation.	Arginine	12-22	vasoactive intestinal peptide	Rattus norvegicus	84-87
7538414-2	1995	We have expressed a recombinant 20 kDa cell-binding fragment of human fibronectin consisting of the ninth and tenth type III modules, which includes the Arg-Gly-Asp (RGD) cell recognition site and a second cell adhesive domain that acts synergistically with the RGD site.	Arginine	153-156	fibronectin 1	Homo sapiens	70-81
7873551-2	1995	We now describe the use of ATP affinity-labeled protein to test the effect of occupancy of that site, which includes the invariant arginine 91, on the activity of cytochrome c with purified cytochrome c reductase and oxidase and its association with the mitochondrial inner membrane.	Arginine	131-139	cytochrome c, somatic	Homo sapiens	163-175
7873551-2	1995	We now describe the use of ATP affinity-labeled protein to test the effect of occupancy of that site, which includes the invariant arginine 91, on the activity of cytochrome c with purified cytochrome c reductase and oxidase and its association with the mitochondrial inner membrane.	Arginine	131-139	cytochrome c, somatic	Homo sapiens	190-202
7873581-1	1995	Analysis of the three dimensional structure of the class A beta-lactamases shows that Arg-244, a spatially conserved residue important for inactivation by clavulanic acid, is held in place by a hydrogen (H) bond from the residue at 276.	Arginine	86-89	amyloid beta precursor protein	Homo sapiens	57-63
7735336-0	1995	Effect of arginine and pyridostigmine on the GHRH-induced GH rise in obesity and Cushing"s syndrome.	Arginine	10-18	growth hormone releasing hormone	Homo sapiens	45-49
7735336-13	1995	ARG enhanced the GHRH-induced GH release in CS (331.9 +/- 51.9 micrograms/L/h vs GHRH alone, P &lt; 0.0001), OB (852.4 +/- 162.1 micrograms/L/h, P &lt; 0.0001) and C (3362.6 +/- 386.0 micrograms/L/h, P &lt; 0.0002).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	17-21
7735336-13	1995	ARG enhanced the GHRH-induced GH release in CS (331.9 +/- 51.9 micrograms/L/h vs GHRH alone, P &lt; 0.0001), OB (852.4 +/- 162.1 micrograms/L/h, P &lt; 0.0001) and C (3362.6 +/- 386.0 micrograms/L/h, P &lt; 0.0002).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	81-85
7541791-4	1995	These findings suggest that Lys-27, Lys-47, and Arg-28 residues may be related to the direct binding to nAChR, and that there is no involvement of Lys-27 in the antigenic determinants of cobrotoxin.	Arginine	48-51	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	104-109
7541791-5	1995	Extending the modification to Arg-30, Arg-33, and Arg-36 caused progressive conformational changes of cobrotoxin and resulted in decreased binding activity to antibody and nAChR.	Arginine	30-33	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	172-177
7541791-5	1995	Extending the modification to Arg-30, Arg-33, and Arg-36 caused progressive conformational changes of cobrotoxin and resulted in decreased binding activity to antibody and nAChR.	Arginine	38-41	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	172-177
7541791-5	1995	Extending the modification to Arg-30, Arg-33, and Arg-36 caused progressive conformational changes of cobrotoxin and resulted in decreased binding activity to antibody and nAChR.	Arginine	38-41	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	172-177
7873546-2	1995	To explore the heparin-binding site of the inhibitor, we have modified the lysine and arginine residues of MPI and its isolated C-terminal domain by using 4-N,N-(dimethylamino)azobenzene-4"-isothiocyano-2"-sulfonic acid (S-DABITC) [Chang, J. Y.	Arginine	86-94	secretory leukocyte peptidase inhibitor	Homo sapiens	107-110
7873546-10	1995	Modification of a limited number of lysine and arginine residues in full-length MPI led to a 6-fold decrease in affinity for heparin.	Arginine	47-55	secretory leukocyte peptidase inhibitor	Homo sapiens	80-83
7539633-1	1995	OBJECTIVE: To find out whether an enteral diet supplemented with arginine, RNA, and omega-3 fatty acids modulated the production of interleukin-1 (IL-1), interleukin-2 (IL-2), IL-2 receptor, interleukin-6 (IL-6), and tumour necrosis factor alpha (TNF-alpha) after operations for upper gastrointestinal cancer.	Arginine	65-73	interleukin 2	Homo sapiens	154-167
7539633-9	1995	CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet.	Arginine	52-60	tumor necrosis factor	Homo sapiens	179-188
7539633-9	1995	CONCLUSION: Supplementation of an enteral diet with arginine, RNA and omega-3 fatty acids can modulate the acute phase reaction as indicated by the reduction in concentrations of TNF-alpha and IL-6 in the group fed the supplemented diet.	Arginine	52-60	interleukin 6	Homo sapiens	193-197
7852505-8	1995	The slightly lower pI of the FDH-specific bands is consistent with the His for Arg substitution predicted by a G to A base transition recently reported in codon 218 of the gene for the variant albumin (Alb-FDH).	Arginine	79-82	albumin	Homo sapiens	202-205
8590320-0	1995	Overcoming the metastasis-enhancing potential of human tumor necrosis factor alpha by introducing the cell-adhesive Arg-Gly-Asp sequence.	Arginine	116-119	tumor necrosis factor	Homo sapiens	55-82
8590320-1	1995	A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed.	Arginine	96-99	tumor necrosis factor	Homo sapiens	26-53
8590320-1	1995	A mutein, F4168, of human tumor necrosis factor alpha (hTNF-alpha) containing the cell-adhesive Arg-Gly-Asp (RGD) sequence near the N terminus was constructed.	Arginine	96-99	tumor necrosis factor	Homo sapiens	55-65
7536905-1	1995	Cultured cerebellar granule neurons were assayed for nitric oxide synthase (NOS) activity by measuring the conversion of L-arginine to L-citrulline.	Arginine	121-131	nitric oxide synthase 2	Homo sapiens	53-74
7829495-2	1995	This mutation, changing a cysteine to an arginine codon at the -8 position of the signal peptide, was associated with deleterious effects on the processing of preproparathyroid hormone to proparathyroid hormone in vitro.	Arginine	41-49	parathyroid hormone	Homo sapiens	159-184
7846628-4	1995	We hypothesize that lipopolysaccharide stimulation of plasma membrane L-arginine transport is mediated via an autocrine cytokine loop involving TNF and IL-1.	Arginine	70-80	tumor necrosis factor	Homo sapiens	144-147
7846628-7	1995	RESULTS: Lipopolysaccharide, IL-1, and TNF all increased both Na+-dependent and Na+-independent carrier-mediated L-arginine transport in a fashion that was both time and dose dependent.	Arginine	113-123	tumor necrosis factor	Homo sapiens	39-42
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	53-63	tumor necrosis factor	Homo sapiens	125-128
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	55-63	tumor necrosis factor	Homo sapiens	125-128
7846628-12	1995	Furthermore, lipopolysaccharide stimulation of arginine transport is mediated in part through an autocrine mechanism involving IL-1 and TNF.	Arginine	47-55	tumor necrosis factor	Homo sapiens	136-139
7772071-0	1995	Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans.	Arginine	0-8	apolipoprotein E	Homo sapiens	47-63
7530004-6	1995	The results demonstrate that the metabolism of arginine in macrophages is controlled by TH1/TH2-dependent cytokines and suggest a regulatory role of arginase on the NO synthesis by intracellular substrate depletion.	Arginine	47-55	negative elongation factor complex member C/D, Th1l	Mus musculus	88-91
7639621-8	1995	This L-arginine-derived autacoid, however, plays a role in the release of CGRP from afferent nerve fibres in the skin since it contributes to the CGRP-mediated vasodilator responses to chemical irritation or immunological challenge via interleukin-1 beta.	Arginine	5-15	interleukin 1 beta	Rattus norvegicus	236-254
7536383-4	1995	The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.	Arginine	96-106	nitric oxide synthase 3	Homo sapiens	18-22
7818548-4	1995	A kinase-negative point mutant of nPKC epsilon, where Lys at the ATP binding site is altered to Arg, does not cause this enhancement of NF-kappa B activation.	Arginine	96-99	protein kinase C, epsilon	Rattus norvegicus	34-46
7611876-5	1995	Furthermore, the polypeptide ORF2 (26.9 kDa) has an unusual primary structure consisting of 3 stretches of acidic amino acid residues and a glycine/arginine rich C-terminal end.	Arginine	148-156	ORF2	Streptomyces phage VWB	29-33
8566930-5	1995	Drugs that inhibit nitric oxide synthesis generally suppress renin release in vivo and in vitro, suggesting a stimulatory role for the L-arginine-nitric oxide pathway in the control of renin secretion.	Arginine	135-145	renin	Homo sapiens	61-66
7538334-6	1995	Since Sin-1 is a nitric oxide (NO) generating compound, we evaluated the possible involvement of the L-arginine metabolic pathway using a competitive inhibitor of L-arginine, NG-monomethyl-L-arginine (LNMMA).	Arginine	101-111	MAPK associated protein 1	Homo sapiens	6-11
7533613-5	1995	The NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) dose-dependently increased L-arginine-induced insulin release.	Arginine	36-46	insulin	Homo sapiens	115-122
7533613-7	1995	However, D-NAME which reportedly has no inhibitory action on NO synthase, modestly increased L-arginine-induced insulin release, but was less effective than L-NAME.	Arginine	93-103	insulin	Homo sapiens	112-119
7533613-16	1995	The intracellular "hydroperoxide donor" tert-butylhydroperoxide in the concentration range of 0.03-3 mM inhibited insulin release stimulated by the nutrient secretagogues glucose and L-arginine.	Arginine	183-193	insulin	Homo sapiens	114-121
7533613-21	1995	Our results strongly suggest that NO is a negative modulator of insulin release induced by the nutrient secretagogues L-arginine and glucose.	Arginine	118-128	insulin	Homo sapiens	64-71
7533622-5	1995	The inhibition of iNOS activity by these S-substituted isothioureas is dose-dependently prevented by excess of L-arginine suggesting that these isothioureas are competitive inhibitors of iNOS at the L-arginine binding site.	Arginine	111-121	nitric oxide synthase 2	Rattus norvegicus	18-22
7533622-5	1995	The inhibition of iNOS activity by these S-substituted isothioureas is dose-dependently prevented by excess of L-arginine suggesting that these isothioureas are competitive inhibitors of iNOS at the L-arginine binding site.	Arginine	111-121	nitric oxide synthase 2	Rattus norvegicus	187-191
7533622-5	1995	The inhibition of iNOS activity by these S-substituted isothioureas is dose-dependently prevented by excess of L-arginine suggesting that these isothioureas are competitive inhibitors of iNOS at the L-arginine binding site.	Arginine	199-209	nitric oxide synthase 2	Rattus norvegicus	18-22
7533622-5	1995	The inhibition of iNOS activity by these S-substituted isothioureas is dose-dependently prevented by excess of L-arginine suggesting that these isothioureas are competitive inhibitors of iNOS at the L-arginine binding site.	Arginine	199-209	nitric oxide synthase 2	Rattus norvegicus	187-191
7850007-4	1995	In group B (N = 6) the GH response to GHRH co-administered with iv ARG on day 1 (1614.2 +/- 146.2 micrograms.l-1.h-1) was higher (p &lt; 0.05) than that of GHRH alone (group A) and persisted unchanged after 7 (1514.7 +/- 366.5 micrograms.l-1.h-1) and 15 days (1631.7 +/- 379.1 micrograms.l-1.h-1) of treatment.	Arginine	67-70	growth hormone releasing hormone	Homo sapiens	156-160
7850007-5	1995	In group C (N = 15) the GH response to GHRH co-administered with oral ARG on day 1 (950.6 +/- 219.4 micrograms.l-1.h-1) was higher (p &lt; 0.03) than that of GHRH alone (group A) but lower (p &lt; 0.05) than that to GHRH plus iv ARG (group B).	Arginine	70-73	growth hormone releasing hormone	Homo sapiens	158-162
7850007-5	1995	In group C (N = 15) the GH response to GHRH co-administered with oral ARG on day 1 (950.6 +/- 219.4 micrograms.l-1.h-1) was higher (p &lt; 0.03) than that of GHRH alone (group A) but lower (p &lt; 0.05) than that to GHRH plus iv ARG (group B).	Arginine	70-73	growth hormone releasing hormone	Homo sapiens	158-162
7850007-5	1995	In group C (N = 15) the GH response to GHRH co-administered with oral ARG on day 1 (950.6 +/- 219.4 micrograms.l-1.h-1) was higher (p &lt; 0.03) than that of GHRH alone (group A) but lower (p &lt; 0.05) than that to GHRH plus iv ARG (group B).	Arginine	229-232	growth hormone releasing hormone	Homo sapiens	39-43
8566930-5	1995	Drugs that inhibit nitric oxide synthesis generally suppress renin release in vivo and in vitro, suggesting a stimulatory role for the L-arginine-nitric oxide pathway in the control of renin secretion.	Arginine	135-145	renin	Homo sapiens	185-190
8568566-0	1995	Thrombin inhibitors based on ketone derivatives of arginine and lysine.	Arginine	51-59	coagulation factor II, thrombin	Homo sapiens	0-8
7601731-8	1995	Infusion of 2,3-DHP resulted in a plasma 2,3-DHP content of 9.4 mumol/L and increased plasma THR, ARG, VAL, PHE, ILE, LEU, and LYS concentrations (P &lt; .10).	Arginine	98-101	dihydropyrimidinase	Homo sapiens	16-19
7729789-0	1995	Blunted GH response to growth hormone-releasing hormone (GHRH) alone or combined with arginine in non-insulin-dependent diabetes mellitus.	Arginine	86-94	growth hormone 1	Homo sapiens	8-10
7729789-12	1995	ARG determined a significant increase of GHRH-induced GH release in all groups (p &lt; 0.01).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	41-45
8568566-3	1995	We now expand on these early findings by reporting on tripeptide based inhibitors of thrombin containing arginine or lysine ketones at the C-terminus.	Arginine	105-113	coagulation factor II, thrombin	Homo sapiens	85-93
7829975-7	1995	Likewise, notwithstanding the ability of LPS-activated macrophages to synthesize reactive nitrogen intermediates (RNI), which was inhibited by L-arginine analogs NG-monomethyl-L-arginine and L-aminoguanidine), as well as by incubation in arginine-free medium, their ability to inhibit the intracellular replication of L. pneumophila was not affected.	Arginine	145-153	toll-like receptor 4	Mus musculus	41-44
7706948-3	1995	Sequencing of the apoE gene from this subject (JB) revealed that the subject was heterozygous for a G to A substitution in codon 136, resulting in the substitution of histidine for arginine; therefore, we have designated this isoform apoE3" (Arg136--&gt;His).	Arginine	181-189	apolipoprotein E	Homo sapiens	18-22
7829975-0	1995	LPS inhibits the intracellular growth of Legionella pneumophila in thioglycolate elicited murine peritoneal macrophages by iron-dependent, tryptophan-independent, oxygen-independent, and arginine-independent mechanisms.	Arginine	187-195	toll-like receptor 4	Mus musculus	0-3
7544862-2	1995	Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries.	Arginine	66-69	interleukin 1 beta	Rattus norvegicus	11-29
7829975-7	1995	Likewise, notwithstanding the ability of LPS-activated macrophages to synthesize reactive nitrogen intermediates (RNI), which was inhibited by L-arginine analogs NG-monomethyl-L-arginine and L-aminoguanidine), as well as by incubation in arginine-free medium, their ability to inhibit the intracellular replication of L. pneumophila was not affected.	Arginine	143-153	toll-like receptor 4	Mus musculus	41-44
7837927-6	1995	The combination of L-arginine (10(-4) M) and superoxide dismutase (600 U) restored low-dose vasopressin vasodilation and suppressed high-dose vasoconstriction in oxyhemoglobin-pretreated arterioles, while they showed little effect when used singly.	Arginine	19-29	arginine vasopressin	Rattus norvegicus	92-103
7837927-7	1995	This study indicates that oxyhemoglobin enhances vasopressin-induced constriction of intracerebral arterioles and these effects can be inhibited by the combination of L-arginine and superoxide dismutase.	Arginine	167-177	arginine vasopressin	Rattus norvegicus	49-60
7475948-3	1995	Pretreatment of the PAG area with L-arginine (1 mumol/rat), a precursor of NO, significantly (p &lt; 0.01) decreased the ET-1-induced effects.	Arginine	34-44	endothelin 1	Rattus norvegicus	121-125
7475948-4	1995	These preliminary data indicate that the L-arginine-NO pathway exerts a functional antagonism on ET-1 induced barrel-rolling at the level of the PAG area.	Arginine	41-51	endothelin 1	Rattus norvegicus	97-101
7544862-2	1995	Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries.	Arginine	66-69	interleukin 1 beta	Rattus norvegicus	31-40
7544862-3	1995	In addition, in the aortic smooth muscle cells cultured in the presence of Arg, LPS- or IL-1 beta-triggered accumulation of nitrite was suppressed by the tyrosine kinase inhibitors.	Arginine	75-78	interleukin 1 beta	Rattus norvegicus	88-97
7544862-4	1995	These results suggest that tyrosine kinase is involved in the LPS- and IL-1 beta-promoted induction of nitric oxide synthase in the vascular smooth muscle, which in turn mediates production of NO from added Arg, thus stimulating formation of cGMP and causing relaxation.	Arginine	207-210	interleukin 1 beta	Rattus norvegicus	71-80
7704243-6	1995	Direct sequencing analysis showed that all mutations were CAA (Gln) to CGA (Arg) transition of codon 61, except for CAA to AAA transversion in one case of follicular carcinoma.	Arginine	76-79	chromogranin A	Homo sapiens	71-74
7704029-4	1995	The mutation substitutes an arginine residue for a highly conserved methionine in a putative actin-binding site near the N terminus of the alpha-tropomyosin.	Arginine	28-36	tropomyosin 1	Homo sapiens	139-156
18475620-1	1995	L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS).	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	114-135
7603523-4	1995	Relatively common mutations include: a nonsense mutation, CGA(Arg) to TGA at codon 49, observed in 30 of 40 American patients; deletion of a single codon 708/709, observed in 4 of 7 Japanese patients; and a missense mutation, GGC(Gly) to AGC(Ser) at codon 204, observed in 5 of 40 American patients.	Arginine	62-65	chromogranin A	Homo sapiens	58-61
7626982-7	1995	The ability of the cells to produce ERF/NO was indirectly estimated, by determining the levels of human platelet guanylate cyclase in the presence of L-arginine, a NO precursor, the accumulation of cGMP in the cells and plasma.	Arginine	150-160	ETS2 repressor factor	Homo sapiens	36-39
7724490-2	1995	We report a contradictory observation made during lyophilization of recombinant tissue-type plasminogen activator (t-PA) formulated in arginine.	Arginine	135-143	plasminogen activator, tissue type	Homo sapiens	80-113
7724490-2	1995	We report a contradictory observation made during lyophilization of recombinant tissue-type plasminogen activator (t-PA) formulated in arginine.	Arginine	135-143	plasminogen activator, tissue type	Homo sapiens	115-119
21043620-4	1995	Thrombin-stimulated platelets but not non-stimulated platelets adhered to the SCSb-9coated surface, and platelet adherence was inhibited in a dose-dependent manner by the tetrapeptide RGDS (Arg-Gly-Asp-Ser).	Arginine	190-193	coagulation factor II, thrombin	Homo sapiens	0-8
8743159-2	1995	NO is synthesized from L-arginine by NO synthase (NOS), which can exist either as a calcium-dependent or a calcium-independent isoform of the enzyme.	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	37-48
7809065-10	1994	The cytochemical reaction for peroxidase tended to decrease or disappear in the eosinophil precursors of the EPO-deficient subject but not of a normal subject as differentiation went on, suggesting that the Arg-->His substitution causes the production of an unstable EPO that undergoes progressive degradation as the cells mature.	Arginine	207-210	eosinophil peroxidase	Homo sapiens	109-112
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Arginine	297-300	tumor necrosis factor	Homo sapiens	64-73
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Arginine	297-300	tumor necrosis factor	Homo sapiens	106-115
8679272-1	1995	In order to elucidate the relationship between N-, C-termini of TNF alpha and it"s biological activity, a TNF alpha derivative 10 (TNF alpha D10) was prepared by changing amino acid at the N-terminus positions Ser(4), Ser(5), Asp(10) and C-terminus position Leu(157) to N-terminus Cys(4), Thr(5), Arg(10) and C-terminus Phe(157) with PCR site-directed mutagenesis.	Arginine	297-300	tumor necrosis factor	Homo sapiens	106-115
7798238-4	1994	The amide bond linking methylcoumarinamide (MCA) and arginine in a tripeptide unrelated in sequence to VIP was cleaved by the light chain with lower affinity and kinetic efficiency (kcat/Km).	Arginine	53-61	vasoactive intestinal peptide	Homo sapiens	103-106
7696618-6	1994	Editing of the glutamine/arginine site was also confirmed for EAA3 (GluR5), which displays a significantly higher extent of editing in specific human brain regions compared with rodent whole brain.	Arginine	25-33	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	62-66
7696618-6	1994	Editing of the glutamine/arginine site was also confirmed for EAA3 (GluR5), which displays a significantly higher extent of editing in specific human brain regions compared with rodent whole brain.	Arginine	25-33	glutamate ionotropic receptor kainate type subunit 1	Homo sapiens	68-73
8001160-4	1994	The ls mice carry a point mutation of the EDN3 gene, which replaces the Arg residue at the C-terminus of the inactive intermediate big EDN3 with a Trp residue.	Arginine	72-75	endothelin 3	Mus musculus	42-46
7809065-10	1994	The cytochemical reaction for peroxidase tended to decrease or disappear in the eosinophil precursors of the EPO-deficient subject but not of a normal subject as differentiation went on, suggesting that the Arg-->His substitution causes the production of an unstable EPO that undergoes progressive degradation as the cells mature.	Arginine	207-210	eosinophil peroxidase	Homo sapiens	267-270
7988726-8	1994	Our model of the 3D structure of the NAD(+)-binding region of ADH shows that Ala-46 is over 10 A from the ribose moiety of NAD+, which would suggest that there is little interaction between this residue and NAD+ and explain why its mutation to arginine has little effect on NAD+ binding.	Arginine	244-252	Alcohol dehydrogenase	Drosophila melanogaster	62-65
7527657-1	1994	The nitric oxide synthases (NOS) are a unique family of P450-type hemoproteins that catalyze the formation of .NO and citrulline from L-arginine, oxygen, and NADPH.	Arginine	134-144	nitric oxide synthase 2	Homo sapiens	4-26
7821796-3	1994	We have investigated the specificity of the proteolytic cleavage in gp100 by introducing mutations within its predicted cleavage site (Arg-Leu-Arg-Arg) and expressed these mutants in recombinant fowlpox virus (FPV).	Arginine	135-138	premelanosome protein	Homo sapiens	68-73
7821796-3	1994	We have investigated the specificity of the proteolytic cleavage in gp100 by introducing mutations within its predicted cleavage site (Arg-Leu-Arg-Arg) and expressed these mutants in recombinant fowlpox virus (FPV).	Arginine	143-146	premelanosome protein	Homo sapiens	68-73
7821796-3	1994	We have investigated the specificity of the proteolytic cleavage in gp100 by introducing mutations within its predicted cleavage site (Arg-Leu-Arg-Arg) and expressed these mutants in recombinant fowlpox virus (FPV).	Arginine	143-146	premelanosome protein	Homo sapiens	68-73
7821796-4	1994	The results show that all three Arg residues at the predicted cleavage site play an important role in the specific proteolytic cleavage of gp100.	Arginine	32-35	premelanosome protein	Homo sapiens	139-144
7982943-7	1994	Automated sequence analysis showed that both modified peptide fractions were derived from the same sequence in AST IV: 63-Leu-Glu-Lys-Cys-Gly-Arg-68.	Arginine	142-145	sulfotransferase family 1A member 1	Rattus norvegicus	111-117
7981204-5	1994	The crystal structure of the inhibitor in complex with human alpha-thrombin showed that dansyl, Arg, and D-pipecolic acid of the active site blocking moiety occupy S3, S1, and S2 subsites of thrombin, respectively, and were therefore designated as P3, P1, and P2 residues.	Arginine	96-99	coagulation factor II, thrombin	Homo sapiens	67-75
7981204-5	1994	The crystal structure of the inhibitor in complex with human alpha-thrombin showed that dansyl, Arg, and D-pipecolic acid of the active site blocking moiety occupy S3, S1, and S2 subsites of thrombin, respectively, and were therefore designated as P3, P1, and P2 residues.	Arginine	96-99	coagulation factor II, thrombin	Homo sapiens	191-199
7992055-3	1994	In three of the four AMPA receptor subunits (GluR-B, -C, and -D), intronic elements determine a codon switch (AGA, arginine, to GGA, glycine) in the primary transcripts in a position termed the R/G site, which immediately precedes the alternatively spliced modules "flip" and "flop."	Arginine	115-123	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	45-51
7889268-3	1994	Tumour necrosis factor (TNF-alpha) may affect the L-arginine/nitric oxide (NO) pathway, thus contributing to the cardiovascular derangements of circulatory shock.	Arginine	50-60	tumor necrosis factor	Rattus norvegicus	24-33
7528998-2	1994	CGRP, in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta.	Arginine	149-159	interleukin 1 beta	Rattus norvegicus	170-179
7786135-2	1994	Its synthesis from L-arginine is assured by NO-synthase, the activity of which is dependent on intracellular calcium concentrations, which are themselves modulated by pharmacological (acetylcholine, serotonin, bradykinin...) or physical factors (shearing forces exerted by blood flow).	Arginine	19-29	kininogen 1	Homo sapiens	210-220
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	tumor necrosis factor	Homo sapiens	230-257
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	tumor necrosis factor	Homo sapiens	259-268
7534181-16	1994	These results suggest that bradykinin acts as both a "trigger" for preconditioning and as one of the mediator protective (antiarrhythmic) substances generated by the myocardium under these conditions.Since the protection afforded both by preconditioning and by local intracoronary infusions of bradykinin is markedly attenuated by an inhibitor of the L-arginine nitric oxide pathway, we suggest that much of the protection afforded by ischaemic preconditioning results from the generation of nitricoxide, and that bradykinin, released early during ischaemia, acts as a stimulant for this generation.	Arginine	351-361	kininogen 1	Canis lupus familiaris	27-37
7889268-16	1994	Our results suggest that TNF-alpha alters both endothelial and muscular L-arginine/nitric oxide pathways which in turn produce vascular dysfunction in SAO shock.	Arginine	72-82	tumor necrosis factor	Rattus norvegicus	25-34
7988466-12	1994	The isolated peptide has an Arg-Arg cleavage site at its junction within the VGF protein.	Arginine	28-31	VGF nerve growth factor inducible	Bos taurus	77-80
7958490-7	1994	Insulin release was reduced in response to 11 mmol/l glucose (61% of control group, P &lt; 0.05) as well as to arginine in the presence of 11 mmol/l glucose (54% of control group, P &lt; 0.01).	Arginine	111-119	insulin	Homo sapiens	0-7
7881430-0	1994	Identification of a homozygous missense mutation (Arg to Gly) in the critical binding region of the human EC-SOD gene (SOD3) and its association with dramatically increased serum enzyme levels.	Arginine	50-53	superoxide dismutase 3	Homo sapiens	106-112
7881430-0	1994	Identification of a homozygous missense mutation (Arg to Gly) in the critical binding region of the human EC-SOD gene (SOD3) and its association with dramatically increased serum enzyme levels.	Arginine	50-53	superoxide dismutase 3	Homo sapiens	119-123
7898082-0	1994	Relation between L-arginine-nitric oxide pathway and endothelin-1 effects in periaqueductal gray area of rats.	Arginine	17-27	endothelin 1	Rattus norvegicus	53-65
7898082-4	1994	Pretreatment with L-arginine (1 mumol per rat), precursor of NO, significantly (p &lt; 0.01) decreased L-NAME-induced potentiation of ET-1 pressor effects.	Arginine	18-28	endothelin 1	Rattus norvegicus	134-138
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Arginine	100-103	Fc receptor, IgE, high affinity I, alpha polypeptide	Mus musculus	176-189
7534728-6	1994	Drugs that inhibit nitric oxide synthesis generally suppress renin release in vivo and in vitro, suggesting a stimulatory role for the L-arginine/nitric oxide pathway in the control of renin secretion.	Arginine	135-145	renin	Homo sapiens	185-190
7534728-12	1994	Administration of L-arginine and nitric oxide donors in vitro and in vivo has variable effects on vasopressin secretion, but the most common one is inhibition.	Arginine	18-28	arginine vasopressin	Homo sapiens	98-109
7537723-2	1994	NO is synthesized from L-arginine by nitric oxide synthase (NOS).	Arginine	23-33	nitric oxide synthase 2	Homo sapiens	37-58
7527855-3	1994	The appearance of a calcium-independent iNOS determined by the conversion of radiolabeled L-arginine to citrulline was observed in cells harvested from lipoplysaccharide (3 mg/kg for 4 hr)-treated rats, with a 10-fold increase in total NOS activity compared with control.	Arginine	90-100	nitric oxide synthase 2	Rattus norvegicus	40-44
7988466-12	1994	The isolated peptide has an Arg-Arg cleavage site at its junction within the VGF protein.	Arginine	32-35	VGF nerve growth factor inducible	Bos taurus	77-80
7538848-1	1994	Alanine-scanning mutagenesis on human growth hormone (hGH) identified 5 primary determinants (Arg 8, Asn 12, Arg 16, Asp 112, and Asp 116) for binding to a monoclonal antibody (MAb 3) (Jin L, Fendly BM, Wells JA, 1992, J Mol Biol 226:851-865).	Arginine	94-97	growth hormone 1	Homo sapiens	38-52
7878073-11	1994	The protective effect of arginine and prazosin in cold-induced hypertension may be related both to their reduction in plasma renin activity and to a reduced responsiveness to angiotensin II, as well as to their abilities to increase the secretion of dopamine.	Arginine	25-33	angiotensinogen	Rattus norvegicus	175-189
7878073-5	1994	Both prazosin and L-arginine reduced the drinking response to administration of angiotensin II.	Arginine	18-28	angiotensinogen	Rattus norvegicus	80-94
7538848-1	1994	Alanine-scanning mutagenesis on human growth hormone (hGH) identified 5 primary determinants (Arg 8, Asn 12, Arg 16, Asp 112, and Asp 116) for binding to a monoclonal antibody (MAb 3) (Jin L, Fendly BM, Wells JA, 1992, J Mol Biol 226:851-865).	Arginine	109-112	growth hormone 1	Homo sapiens	38-52
7740447-2	1994	Mutation of Arg-178 (CGG) to Gln (CAG) [mutation I] was detected in exon VII, in the vicinity of activation peptide cleavage site by thrombin.	Arginine	12-15	coagulation factor II, thrombin	Homo sapiens	133-141
7756983-11	1994	In PPACK-thrombin, the side chain of Asp 189 and the segment Arg 221A-Gly 223 move to provide space for the inhibitor, whereas in hirugen-thrombin, the Ala 190-Gly 197 movement expands the active site region.	Arginine	61-64	coagulation factor II, thrombin	Homo sapiens	9-17
7756983-11	1994	In PPACK-thrombin, the side chain of Asp 189 and the segment Arg 221A-Gly 223 move to provide space for the inhibitor, whereas in hirugen-thrombin, the Ala 190-Gly 197 movement expands the active site region.	Arginine	61-64	coagulation factor II, thrombin	Homo sapiens	138-146
7740452-0	1994	Alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg) inhibits the contact pathway of intrinsic coagulation and alters the release of human neutrophil elastase during simulated extracorporeal circulation.	Arginine	44-47	serpin family A member 1	Homo sapiens	0-19
7740452-4	1994	alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg), a mutant of alpha 1-antitrypsin, is a potent inhibitor of plasma kallikrein and thrombin.	Arginine	44-47	serpin family A member 1	Homo sapiens	0-19
7740452-4	1994	alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg), a mutant of alpha 1-antitrypsin, is a potent inhibitor of plasma kallikrein and thrombin.	Arginine	44-47	serpin family A member 1	Homo sapiens	62-81
7740452-4	1994	alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg), a mutant of alpha 1-antitrypsin, is a potent inhibitor of plasma kallikrein and thrombin.	Arginine	44-47	coagulation factor II, thrombin	Homo sapiens	130-138
7880938-0	1994	Arginine but not pyridostigmine, a cholinesterase inhibitor, enhances the GHRH-induced GH rise in patients with anorexia nervosa.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	74-78
7980464-2	1994	Near the thrombin cleavage site in protein C is a cluster of basic residues, at positions P5" (Lys-174), P8" (Arg-177) and P9" (Arg-178).	Arginine	110-113	coagulation factor II, thrombin	Homo sapiens	9-17
7973537-1	1994	Insulin secretory reserve assessed by the method of glucose potentiation of arginine induced insulin secretion is decreased in non-diabetic transplant recipients using triple immunosuppressive therapy with prednisone, cyclosporine, and azathioprine.	Arginine	76-84	insulin	Homo sapiens	0-7
7973537-2	1994	To determine whether this defect is due to the combined therapy or to a single agent, we examined the acute insulin response (AIR) to arginine at 5 levels of glucose (basal and 4 levels achieved by continuous glucose infusions) in 7 normoglycemic arthritis patients (AP) using long term prednisone (10.3 +/- 37 mg for 83 +/- 37 months), and 4 normoglycemic psoriasis patients (PP) using long term cyclosporine (350 +/- 61 mg for 25 +/- 4 months) and compared them with matched healthy controls (CON).	Arginine	134-142	insulin	Homo sapiens	108-115
7526712-0	1994	IL-1 inhibits beta-adrenergic control of cardiac calcium current: role of L-arginine/nitric oxide pathway.	Arginine	74-84	interleukin 1 beta	Homo sapiens	0-4
7526712-4	1994	This IL-1-mediated decrease in beta-responsiveness was usually observed with pretreatment periods of &gt; 1 h and varied as a function of the L-arginine concentration of the pretreatment medium.	Arginine	142-152	interleukin 1 beta	Homo sapiens	5-9
7947615-0	1994	Susceptibility to diet-induced atherosclerosis in transgenic mice expressing a dysfunctional human apolipoprotein E(Arg 112,Cys142).	Arginine	116-119	apolipoprotein E	Homo sapiens	99-115
7526387-0	1994	Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.	Arginine	36-46	superoxide dismutase 1	Homo sapiens	109-129
7526387-1	1994	Although nitric oxide (NO) appears to be one of the oxidation products of L-arginine catalyzed by NO synthase (NOS; EC 1.14.13.39), past studies on the measurement of NO in cell-free enzymatic assays have not been based on the direct detection of the free NO molecule.	Arginine	74-84	nitric oxide synthase 2	Homo sapiens	98-109
7526387-7	1994	SOD appears to elicit a novel biological action, perhaps accelerating the conversion of an intermediate in the L-arginine-NO pathway such as nitroxyl (HNO) to NO.	Arginine	111-121	superoxide dismutase 1	Homo sapiens	0-3
7978053-6	1994	RESULTS: A C-to-T transition was identified at a CpG site in codon 196 resulting in a change from arginine to a stop codon (CGA to TGA).	Arginine	98-106	chromogranin A	Homo sapiens	124-127
7980464-2	1994	Near the thrombin cleavage site in protein C is a cluster of basic residues, at positions P5" (Lys-174), P8" (Arg-177) and P9" (Arg-178).	Arginine	128-131	coagulation factor II, thrombin	Homo sapiens	9-17
7867388-1	1994	The aim of this study is to investigate the effects of nitric oxide, formed from L-arginine, on the production of endothelin-1 in vivo and in cultured endothelial cells.	Arginine	81-91	endothelin 1	Canis lupus familiaris	114-126
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	240-248	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	250-253	major histocompatibility complex, class II, DR beta 1	Homo sapiens	26-30
7530691-7	1994	was stimulated by the cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), an effect enhanced by endotoxin [lipopolysaccharide (LPS)], reduced by the competitive inhibitor of L-arginine metabolism, NG-monomethyl-L-arginine (L-NMMA) and inhibited by cycloheximide.	Arginine	207-217	tumor necrosis factor	Rattus norvegicus	95-104
7962332-9	1994	The preservation of ACTH and GH responses to metyrapone and arginine, respectively, suggests adequate pituitary functional reserve in IDDM patients in strict glycemic control in response to nonhypoglycemic stimuli.	Arginine	60-68	proopiomelanocortin	Homo sapiens	20-31
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Arginine	91-94	angiotensinogen	Homo sapiens	71-85
24226385-2	1994	The electrospray ionization mass spectra of histidine-containing human angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) and angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu) in the presence of zinc show abundant multiply charged ions for the zinc-attached peptide [M + aZn(2+) +(c - 2a)H(+)](c+), where a = 1, 2 and c is charge.	Arginine	91-94	angiotensinogen	Homo sapiens	71-84
7532811-7	1994	As a cytochrome P-450, NOS catalyzes a heme-mediated reduction of molecular oxygen, resulting in the formation of H2O2 in the absence of L-arginine.	Arginine	137-147	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	5-21
7847613-8	1994	Finally, we observed that inhibition of NO formation by the administration of the arginine derivative L omega nitro-L-arginine-methylester significantly augmented ACTH secretion in all three experimental groups, and reversed the decreased corticotrophs" response to IL-1 beta caused by prenatal alcohol.	Arginine	82-90	interleukin 1 beta	Rattus norvegicus	266-275
7900076-10	1994	This shows that thrombin can cleave at all three arginine sites and that cleavage at each of these sites results in the loss of APC cofactor activity.	Arginine	49-57	coagulation factor II, thrombin	Homo sapiens	16-24
7900081-1	1994	A genetic polymorphism (Arg/Gln353) of coagulation factor VII was recently identified and shown to be associated with differences in basal factor VII coagulant activity.	Arginine	24-27	coagulation factor VII	Homo sapiens	39-61
7929350-5	1994	We have examined by site-specific mutagenesis of a recombinant PLA2 that is identical to an enzyme in human synovial fluid (containing His-6, Arg-7, Lys-10, and Lys-15 and a global net charge of +15) the role of basic residues in this region in PLA2 action against PLA-deficient (pldA-) E. coli.	Arginine	142-145	phospholipase A2 group IB	Homo sapiens	63-67
7929356-4	1994	The amino acids are localized in three loops, which form a putative ridge on the most exposed side of the Fc epsilon 3 domain of IgE and include Arg-408, Ser-411, Lys-415, Glu-452, Arg-465, and Met-469.	Arginine	145-148	immunoglobulin heavy constant epsilon	Homo sapiens	129-132
7937865-3	1994	We compared the binding and biological actions of EGF and TGF-alpha in Chinese hamster ovary (CHO) cells expressing either wild-type human EGFR (HER497R) or a variant EGFR that has an arginine-to-lysine substitution in the extracellular domain at codon 497 (HER497K) within subdomain IV of EGFR.	Arginine	184-192	epidermal growth factor receptor	Homo sapiens	167-171
7937865-3	1994	We compared the binding and biological actions of EGF and TGF-alpha in Chinese hamster ovary (CHO) cells expressing either wild-type human EGFR (HER497R) or a variant EGFR that has an arginine-to-lysine substitution in the extracellular domain at codon 497 (HER497K) within subdomain IV of EGFR.	Arginine	184-192	epidermal growth factor receptor	Homo sapiens	167-171
7918609-0	1994	Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108--&gt;Arg) and A-I Hita (Ala-95--&gt;Asp).	Arginine	105-108	apolipoprotein A1	Homo sapiens	34-52
7918609-2	1994	In the first case, apo A-I Tsushima, sequencing following amplification by the polymerase chain reaction (PCR) revealed a residue 108 missense mutation (TGG--&gt;CGG, Trp--&gt;Arg) in exon 4.	Arginine	176-179	apolipoprotein A1	Homo sapiens	19-26
7530568-0	1994	NO-dependent and -independent elevation of plasma levels of insulin and glucose in rats by L-arginine.	Arginine	91-101	insulin	Homo sapiens	60-67
7530568-2	1994	L-Arginine elevates plasma insulin in man.	Arginine	0-10	insulin	Homo sapiens	27-34
7530568-3	1994	Recent in vitro data indicate that this is based on stimulation of endogenous nitric oxide (NO) with subsequent pancreatic release of insulin by L-arginine.	Arginine	145-155	insulin	Homo sapiens	134-141
7530568-9	1994	Before L-NAME, L-arginine elevated plasma insulin from about 15 to 65 ul-1 and glucose from 5.2 to 6.7 mmol l-1.	Arginine	15-25	insulin	Homo sapiens	42-49
7530568-12	1994	L-NAME alone had no effect on plasma insulin and glucose levels, but diminished the effects of a low dose (25 mg kg-1 min-1) of L-arginine on plasma insulin by about 40%, and that on plasma glucose by more than 90%.	Arginine	128-138	insulin	Homo sapiens	149-156
7530568-13	1994	In contrast, the effects of a high dose (200 mg kg-1 min-1) of L-arginine on plasma insulin and glucose levels were not affected by L-NAME.	Arginine	63-73	insulin	Homo sapiens	84-91
7530568-24	1994	We conclude that L-arginine separately elevates plasma insulin and glucose levels, both by NO-dependent and -independent mechanisms.	Arginine	17-27	insulin	Homo sapiens	55-62
7865680-8	1994	These observations also demonstrate that the fibrinogen alpha-chain arginine-glycine-aspartic acid-phenylalanine and arginine-glycine-aspartic acid-serine sequences are not necessary or sufficient to mediate the adhesion of resting or stimulated platelets in plasma to fibrinogen.	Arginine	68-76	fibrinogen beta chain	Homo sapiens	45-55
7851271-2	1994	An infusion of L-arginine was used to inhibit TR of transferrin, permitting the determination of both GC and TR of transferrin in 64 patients with non-insulin-dependent diabetes mellitus (NIDDM), with or without microtransferrinuria.	Arginine	15-25	transferrin	Homo sapiens	52-63
7851271-2	1994	An infusion of L-arginine was used to inhibit TR of transferrin, permitting the determination of both GC and TR of transferrin in 64 patients with non-insulin-dependent diabetes mellitus (NIDDM), with or without microtransferrinuria.	Arginine	15-25	transferrin	Homo sapiens	115-126
7937939-1	1994	The Ca2+ permeability and the rectifying properties of the glutamate receptors assembled from the subunits GluR1-GluR4 depend upon a critical Arg in the GluR2 subunit located in a domain that has been proposed to span the membrane.	Arginine	142-145	glutamate ionotropic receptor AMPA type subunit 4	Homo sapiens	113-118
7929288-2	1994	Maturation of the insulin proreceptor in a late Golgi compartment requires cleavage at an Arg-Lys-Arg-Arg processing site, suggesting involvement of furin, a transmembrane serine protease of the Kex2 family of processing enzymes.	Arginine	90-93	insulin	Homo sapiens	18-25
7929288-2	1994	Maturation of the insulin proreceptor in a late Golgi compartment requires cleavage at an Arg-Lys-Arg-Arg processing site, suggesting involvement of furin, a transmembrane serine protease of the Kex2 family of processing enzymes.	Arginine	98-101	insulin	Homo sapiens	18-25
7929288-2	1994	Maturation of the insulin proreceptor in a late Golgi compartment requires cleavage at an Arg-Lys-Arg-Arg processing site, suggesting involvement of furin, a transmembrane serine protease of the Kex2 family of processing enzymes.	Arginine	98-101	insulin	Homo sapiens	18-25
7929152-0	1994	The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function.	Arginine	42-45	fibronectin 1	Homo sapiens	59-70
7530473-13	1994	These results demonstrate that vasodilator responses to both bradykinin and substance P are mediated in part via the L-arginine/NO pathway.	Arginine	117-127	kininogen 1	Homo sapiens	61-71
7530473-13	1994	These results demonstrate that vasodilator responses to both bradykinin and substance P are mediated in part via the L-arginine/NO pathway.	Arginine	117-127	tachykinin precursor 1	Homo sapiens	76-87
7859596-3	1994	Arginine 65 of the proinsulin molecule might be a hot spot of the insulin gene.	Arginine	0-8	insulin	Homo sapiens	19-29
7859596-3	1994	Arginine 65 of the proinsulin molecule might be a hot spot of the insulin gene.	Arginine	0-8	insulin	Homo sapiens	22-29
8083219-2	1994	Two alleles of the cystatin D gene (CST5), encoding protein variants with either Cys or Arg as residue 26 in their 122-residue polypeptide chains, are present in the population.	Arginine	88-91	cystatin D	Homo sapiens	19-29
7858061-4	1994	The IL-4-dependent IgE production was significantly reduced (p &lt; 0.001) in the presence of N omega-monomethyl-L-arginine (LNMMA), an inhibitor of the NO-synthase pathway; this inhibition was partially reverted with an excess of L-arginine.	Arginine	113-123	interleukin 4	Homo sapiens	4-8
8084608-0	1994	A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.	Arginine	50-53	tumor protein p53	Homo sapiens	114-117
8084608-0	1994	A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.	Arginine	50-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	133-137
8084608-0	1994	A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1.	Arginine	50-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	138-142
8084608-6	1994	Transfection studies demonstrated that the expression of the Arg allele of WAF1/CIP1 was not associated with loss of tumor suppressor activity.	Arginine	61-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-79
8084608-6	1994	Transfection studies demonstrated that the expression of the Arg allele of WAF1/CIP1 was not associated with loss of tumor suppressor activity.	Arginine	61-64	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-84
7523213-8	1994	Immunohistochemistry showed a significant increase in P-selectin expression after 60 minutes of superfusion with L-NAME, which was attenuated by L-arginine, hSOD, and 8-br-cGMP.	Arginine	145-155	selectin P	Rattus norvegicus	54-64
7525624-4	1994	Spontaneous overnight and arginine-stimulated GH secretion, insulin, IGF-I, IGF-II, IGF-binding protein-1 (IGFBP-1), and IGFBP-3 levels were measured before, during, and after daily 10-h sc infusions of saline or IGF-I (20 micrograms/kg.h).	Arginine	26-34	insulin	Homo sapiens	60-67
7525624-4	1994	Spontaneous overnight and arginine-stimulated GH secretion, insulin, IGF-I, IGF-II, IGF-binding protein-1 (IGFBP-1), and IGFBP-3 levels were measured before, during, and after daily 10-h sc infusions of saline or IGF-I (20 micrograms/kg.h).	Arginine	26-34	insulin like growth factor 1	Homo sapiens	76-81
8083219-2	1994	Two alleles of the cystatin D gene (CST5), encoding protein variants with either Cys or Arg as residue 26 in their 122-residue polypeptide chains, are present in the population.	Arginine	88-91	cystatin D	Homo sapiens	36-40
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	60-68	apolipoprotein E	Homo sapiens	75-80
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	50-55
8071364-2	1994	Human apolipoprotein (apo) E4 (arginine at residue 112) preferentially associates with very low density lipoproteins (VLDL), and apoE3 (cysteine at 112) associates with high density lipoproteins.	Arginine	31-39	apolipoprotein E	Homo sapiens	6-28
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	75-80
8071364-9	1994	Compared with the known four-helix bundle structure of apoE3, the only significant differences in the apoE4 structure were that glutamic acid 109 formed a salt bridge with arginine 112 and that the arginine 61 side chain was displaced to a new position.	Arginine	172-180	apolipoprotein E	Homo sapiens	55-60
8071364-9	1994	Compared with the known four-helix bundle structure of apoE3, the only significant differences in the apoE4 structure were that glutamic acid 109 formed a salt bridge with arginine 112 and that the arginine 61 side chain was displaced to a new position.	Arginine	172-180	apolipoprotein E	Homo sapiens	102-107
8071364-9	1994	Compared with the known four-helix bundle structure of apoE3, the only significant differences in the apoE4 structure were that glutamic acid 109 formed a salt bridge with arginine 112 and that the arginine 61 side chain was displaced to a new position.	Arginine	198-206	apolipoprotein E	Homo sapiens	55-60
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	145-150
8071364-9	1994	Compared with the known four-helix bundle structure of apoE3, the only significant differences in the apoE4 structure were that glutamic acid 109 formed a salt bridge with arginine 112 and that the arginine 61 side chain was displaced to a new position.	Arginine	198-206	apolipoprotein E	Homo sapiens	102-107
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	145-150
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	50-55
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	75-80
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	145-150
8071364-10	1994	Site-directed mutagenesis of glutamic acid 109 in apoE3 and arginine 61 in apoE4 demonstrated that the position of the arginine 61 side chain in apoE4 was critical in determining apoE4 lipoprotein distribution, suggesting that arginine 61 interacted with the carboxyl-terminal domain to direct binding to VLDL.	Arginine	119-127	apolipoprotein E	Homo sapiens	145-150
7955906-14	1994	Urinary NO3- excretion increased by 79.7% after L-arginine.	Arginine	48-58	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
7712121-1	1994	Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.	Arginine	152-155	CD4 molecule	Homo sapiens	60-63
7712121-1	1994	Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.	Arginine	152-155	CD4 molecule	Homo sapiens	162-165
7955444-2	1994	Arginine stimulates PRL secretion through pathways other than the activation of TRH receptors or dopamine-dependent mechanisms.	Arginine	0-8	prolactin	Homo sapiens	20-23
7955444-3	1994	We therefore investigated PRL responses to arginine in patients with hyperthyroidism.	Arginine	43-51	prolactin	Homo sapiens	26-29
7955444-9	1994	PRL responses to arginine, small but clearly detectable in normal men, were completely abolished in hyperthyroid men (peak PRL levels, 248 +/- 48 mU/l, vs 112 +/- 14, P &lt; 0.01).	Arginine	17-25	prolactin	Homo sapiens	0-3
7955444-9	1994	PRL responses to arginine, small but clearly detectable in normal men, were completely abolished in hyperthyroid men (peak PRL levels, 248 +/- 48 mU/l, vs 112 +/- 14, P &lt; 0.01).	Arginine	17-25	prolactin	Homo sapiens	123-126
7955444-10	1994	CONCLUSIONS: PRL responses to arginine are impaired in hyperthyroid patients.	Arginine	30-38	prolactin	Homo sapiens	13-16
7955444-11	1994	Therefore, arginine should be added to the list of PRL stimuli whose responses are blunted in hyperthyroidism.	Arginine	11-19	prolactin	Homo sapiens	51-54
7915241-0	1994	Hyperinsulinemia decreases second-phase but not first-phase arginine-induced insulin release in humans.	Arginine	60-68	insulin	Homo sapiens	5-12
7915241-1	1994	The aim of this study was to investigate the effect of hyperinsulinemia on the first and second phase of arginine-induced insulin release in humans.	Arginine	105-113	insulin	Homo sapiens	60-67
7988299-0	1994	Arginine-induced insulin release in glucokinase-deficient subjects.	Arginine	0-8	insulin	Homo sapiens	17-24
7915241-5	1994	The time course of insulin release during the arginine test was calculated from C-peptide concentrations by using C-peptide kinetic modeling and deconvolution.	Arginine	46-54	insulin	Homo sapiens	19-26
7915241-6	1994	In particular, first-phase and second-phase insulin response was obtained by integrating the time course of the insulin release during either the first 5 min or the following 40 min of the arginine test, respectively.	Arginine	189-197	insulin	Homo sapiens	44-51
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	163-171	Fc gamma receptor and transporter	Homo sapiens	207-218
7915241-6	1994	In particular, first-phase and second-phase insulin response was obtained by integrating the time course of the insulin release during either the first 5 min or the following 40 min of the arginine test, respectively.	Arginine	189-197	insulin	Homo sapiens	112-119
7988299-1	1994	OBJECTIVE: In eight glucokinase (GCK)-deficient subjects, we have investigated insulin secretion rates (ISRs) in response to intravenous arginine.	Arginine	137-145	insulin	Homo sapiens	79-86
7988299-8	1994	RESULTS: Two minutes after the injection of arginine, the increment in ISR was 30.17 +/- 10.01 pmol insulin.kg-1.min-1 in patients and 36.25 +/- 15.46 pmol insulin.kg-1.min-1 in control subjects (P = 0.38).	Arginine	44-52	insulin	Homo sapiens	100-107
7988299-8	1994	RESULTS: Two minutes after the injection of arginine, the increment in ISR was 30.17 +/- 10.01 pmol insulin.kg-1.min-1 in patients and 36.25 +/- 15.46 pmol insulin.kg-1.min-1 in control subjects (P = 0.38).	Arginine	44-52	insulin	Homo sapiens	156-163
8083346-6	1994	The COOH-terminal 32-residue peptide of cloned hamster preproBNP with 122 amino acids, preceded by a single arginine residue, supposedly represents hamster BNP showing &lt; 50% homology to rat BNP.	Arginine	108-116	natriuretic peptide B	Rattus norvegicus	156-159
8088449-6	1994	Both of the recessive lethal usp mutations associated with this "cleft thorax" phenotype involved substitutions of conserved arginine residues in the DNA-binding domain, although the frequency of the phenotype was not the same for the two alleles.	Arginine	125-133	ultraspiracle	Drosophila melanogaster	29-32
7835634-5	1994	The preincubation with the precursor of NO synthesis, L-arginine (10(-4) M), reduced KCl-induced contraction and increased the BK relaxation.	Arginine	54-64	kininogen 1	Homo sapiens	127-129
8063713-7	1994	The second substrate, NFF-2 (Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2, where Nva is norvaline), was hydrolyzed 60 times more rapidly by MMP-3 (kcat/Km = 59,400 s-1 M-1) than MMP-1.	Arginine	33-36	matrix metallopeptidase 3	Homo sapiens	148-153
7520097-3	1994	Conserved within this variable region is the sequence Arg-Gly-Asp (RGD), which, in the Ad2 penton base, binds to integrins in the target cell membrane, enhancing the rate or the efficiency of infection.	Arginine	54-57	apolipoprotein E	Homo sapiens	87-90
7898466-5	1994	2"-deoxyNAD+ has also been used to characterize the arg-specific mono(2"-deoxyADP-ribosyl)ation reaction of PARP with cholera toxin or avian mono(ADP-ribosyl)transferase.	Arginine	52-55	poly(ADP-ribose) polymerase 1	Homo sapiens	108-112
8074665-0	1994	Involvement of Fc epsilon RII/CD23 and L-arginine dependent pathway in IgE-mediated activation of human eosinophils.	Arginine	39-49	immunoglobulin heavy constant epsilon	Homo sapiens	71-74
7520872-0	1994	Identification of imidazole as L-arginine-competitive inhibitor of porcine brain nitric oxide synthase.	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	81-102
7836701-7	1994	Islets from rats treated with CCl4 for 17 weeks showed normal secretory response to 20 mmol/l L-arginine.	Arginine	94-104	C-C motif chemokine ligand 4	Rattus norvegicus	30-34
7935330-4	1994	Nearly all G protein-coupled receptors studied to date, including the GRP-R, possess two highly conserved amino acids that are important in mediating receptor-G protein coupling to second messengers, i.e., arginine in the proximal second intracellular loop and alanine in the distal third intracellular loop.	Arginine	206-214	gastrin releasing peptide receptor	Homo sapiens	70-75
11550679-4	1994	As measured by the accumulation of NO2- in culture medium, NO production by IL-1-stimulated chondrocytes was inhibited by the NO synthase inhibitor Ng-monomethyl-L-arginine (NMA) and dependent on the presence of exogenous L-arginine.	Arginine	162-172	interleukin 1 beta	Homo sapiens	76-80
7765234-3	1994	The optimum renaturation conditions were found to be incubation for 90 h at pH 7.5 and 15 degrees C. The resulting completely refolded r-AD was purified to homogeneity by anion-exchange and arginine-affinity chromatography and its activity yield was 72.5%.	Arginine	190-198	Ras-related associated with diabetes	Mus musculus	135-139
8060312-1	1994	Platinum electrodes (PLE) have been used recently to study the physiologic effects of the enzymatic conversion of L-arginine (L-arg) to nitric oxide (NO) by nitric oxide synthase (NOS).	Arginine	114-124	nitric oxide synthase 2	Homo sapiens	157-178
8060312-1	1994	Platinum electrodes (PLE) have been used recently to study the physiologic effects of the enzymatic conversion of L-arginine (L-arg) to nitric oxide (NO) by nitric oxide synthase (NOS).	Arginine	114-119	nitric oxide synthase 2	Homo sapiens	157-178
8060312-9	1994	We conclude that PLE can catalytically convert L-Arg to NO3- via electron transfer without NOS.	Arginine	47-52	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Arginine	160-163	coagulation factor II	Mus musculus	44-52
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Arginine	160-163	coagulation factor II	Mus musculus	125-133
8049209-8	1994	Missense mutation analysis indicates that the Lys and Arg residues are essential for calmodulin binding to the synthetic peptide RYR1 PM3.	Arginine	54-57	calmodulin 1	Homo sapiens	85-95
7519607-0	1994	L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	77-98
7519607-1	1994	Neuronal nitric oxide synthase (NOS) is a calmodulin-dependent, flavin-containing hemoprotein that forms NO from L-arginine, NADPH, and molecular oxygen.	Arginine	113-123	nitric oxide synthase 2	Homo sapiens	9-30
7519607-1	1994	Neuronal nitric oxide synthase (NOS) is a calmodulin-dependent, flavin-containing hemoprotein that forms NO from L-arginine, NADPH, and molecular oxygen.	Arginine	113-123	calmodulin 1	Homo sapiens	42-52
7519607-13	1994	Anaerobic titration of a calmodulin-bound, L-arginine-free NOS with NADPH led to incomplete reduction of the heme iron; full reduction was achieved only in the presence of added L-arginine.	Arginine	43-53	calmodulin 1	Homo sapiens	25-35
7519607-13	1994	Anaerobic titration of a calmodulin-bound, L-arginine-free NOS with NADPH led to incomplete reduction of the heme iron; full reduction was achieved only in the presence of added L-arginine.	Arginine	178-188	calmodulin 1	Homo sapiens	25-35
8001644-12	1994	was enhanced in smooth muscle cells from both normotensive and hypertensive rats when the cells were treated with L-arginine after exposure to interleukin-1 beta.	Arginine	114-124	interleukin 1 beta	Rattus norvegicus	143-161
8037207-3	1994	In this study, we investigated 52 unrelated HS-RDEB patients and 2 patients with RDEB inversa for the presence, at CpG dinucleotides, of mutations changing CGA arginine codons to premature stop codons TGA within the COL7A1 gene.	Arginine	160-168	chromogranin A	Homo sapiens	156-159
8050589-5	1994	The Adda and Arg side chains protrude from the ring distal from one another caused by the repulsion between the guanido function of Arg and the hydrophobic Adda.	Arginine	13-16	adducin 1	Homo sapiens	156-160
8050589-5	1994	The Adda and Arg side chains protrude from the ring distal from one another caused by the repulsion between the guanido function of Arg and the hydrophobic Adda.	Arginine	132-135	adducin 1	Homo sapiens	4-8
7976300-8	1994	Quantification of human C5a des Arg was performed with a recently developed sandwich ELISA technique, using neoepitope-specific monoclonal antibodies.	Arginine	32-35	complement C5a receptor 1	Homo sapiens	24-27
7976300-11	1994	Levels of C5a des Arg in plasma incubated in the presence of polylactic acid were higher than in plasma incubated in the absence of PLA.	Arginine	18-21	complement C5a receptor 1	Homo sapiens	10-13
8049245-2	1994	Exposure of HGL to trypsin led to the production of three identified fragments (H1, H2 and H3) resulting from cleavage sites at Lys-4 and Arg-229.	Arginine	138-141	lipase F, gastric type	Homo sapiens	12-15
8049245-8	1994	One cleavage site (Arg-229) was found to be identical in both RGL and HGL.	Arginine	19-22	lipase F, gastric type	Homo sapiens	70-73
7949246-2	1994	We prepared three peptides derived from the type III connecting segment domain (IIICS) of fibronectin: Glu-Ile-Leu-Asp-Val (EILDV), Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (EILDVPST), Arg-Glu-Asp-Val (REDV), and a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg (YIGSR).	Arginine	176-179	fibronectin 1	Homo sapiens	90-101
7949246-2	1994	We prepared three peptides derived from the type III connecting segment domain (IIICS) of fibronectin: Glu-Ile-Leu-Asp-Val (EILDV), Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (EILDVPST), Arg-Glu-Asp-Val (REDV), and a laminin-related peptide, Tyr-Ile-Gly-Ser-Arg (YIGSR).	Arginine	247-250	fibronectin 1	Homo sapiens	90-101
7841300-0	1994	Fibrinogen Milano V: a congenital dysfibrinogenaemia with a gamma 275 Arg--&gt;Cys substitution.	Arginine	70-73	fibrinogen beta chain	Homo sapiens	0-10
7524699-6	1994	The maximally stimulating dose of IL-1 beta (50 ng/ml) produced a 10-fold increase in nitrite accumulation by 96 h of culture, an effect reduced 23% when cells were cultured in substrate (i.e., arginine)-free media.	Arginine	194-202	interleukin 1 beta	Rattus norvegicus	34-43
8053891-5	1994	In the present report we show that the presence of the Arg-to-Cys point mutation in the recombinant RYR expressed in COS-7 transfected cells causes abnormal cytosolic Ca2+ transients in response to 4-chloro-m-cresol, an agent capable of eliciting in vitro contracture of MH-susceptible muscles.	Arginine	55-58	ryanodine receptor 1	Homo sapiens	100-103
7993663-3	1994	Two patients with propionic acidemia had decreased growth hormone secretion in response to provocative stimuli (intravenous L-arginine and oral levodopa or clonidine); the remaining subjects had sufficient growth hormone secretion.	Arginine	124-134	growth hormone 1	Homo sapiens	51-65
7749373-2	1994	The first documented mutation responsible for total human kininogen deficiency has been characterized as a single base change from CGA to TGA in exon 5, resulting in an Arg--&gt;Stop mutation inherited as an autosomal recessive trait.	Arginine	169-172	chromogranin A	Homo sapiens	131-134
7951671-8	1994	A recent study of the level of pituitary resistance in a large kindred with GRTH (ARG-320-HIS mutation) indicated a contributory gene in the regulation of thyroid hormone action.	Arginine	82-85	thyroid hormone receptor beta	Homo sapiens	76-80
7518750-8	1994	Tumoricidal activity of both these effector cells, assessed against YAC-1 and P815 target cells, respectively, was indeed significantly reduced when cytotoxic assays were performed in arginine-free medium or in the presence of the L-arginine analog L-N-monomethyl-arginine, which inhibits nitroxide formation from L-arginine.	Arginine	184-192	ADP-ribosyltransferase 1	Mus musculus	68-73
7518750-8	1994	Tumoricidal activity of both these effector cells, assessed against YAC-1 and P815 target cells, respectively, was indeed significantly reduced when cytotoxic assays were performed in arginine-free medium or in the presence of the L-arginine analog L-N-monomethyl-arginine, which inhibits nitroxide formation from L-arginine.	Arginine	231-241	ADP-ribosyltransferase 1	Mus musculus	68-73
8001287-1	1994	Familial defective apolipoprotein B-100 (FDB) is a genetic disorder resulting from a mutation in the apolipoprotein B-100 (apo B-100) gene, most frequently at position 3500, in which arginine is substituted for glutamine in the mature protein.	Arginine	183-191	apolipoprotein B	Homo sapiens	19-39
8001287-1	1994	Familial defective apolipoprotein B-100 (FDB) is a genetic disorder resulting from a mutation in the apolipoprotein B-100 (apo B-100) gene, most frequently at position 3500, in which arginine is substituted for glutamine in the mature protein.	Arginine	183-191	apolipoprotein B	Homo sapiens	101-121
8001287-1	1994	Familial defective apolipoprotein B-100 (FDB) is a genetic disorder resulting from a mutation in the apolipoprotein B-100 (apo B-100) gene, most frequently at position 3500, in which arginine is substituted for glutamine in the mature protein.	Arginine	183-191	apolipoprotein B	Homo sapiens	123-132
8076711-3	1994	In this study, the effect of L-arginine supplementation on natural cytotoxicity was determined in patients with breast cancer receiving CHOP chemotherapy.	Arginine	29-39	DNA damage inducible transcript 3	Homo sapiens	136-140
8076711-5	1994	Those patients receiving L-arginine supplementation (30 g/day for 3 days prior to each course of chemotherapy) had a smaller and delayed onset of immunosuppression (day 14), compared with those patients who had CHOP only (day 9).	Arginine	25-35	DNA damage inducible transcript 3	Homo sapiens	211-215
8076711-6	1994	L-Arginine was able to repeatedly stimulate NK and LAK cell cytotoxicity in patients who were receiving CHOP chemotherapy (P &lt; 0.003).	Arginine	0-10	DNA damage inducible transcript 3	Homo sapiens	104-108
7518842-7	1994	Using a myocardial cytosolic iNOS preparation, nitrite formation from L-arginine and [3H] citrulline formation from [3H]L-arginine were increased significantly in the rejecting allogeneic grafts (P &lt; 0.01).	Arginine	70-80	nitric oxide synthase 2	Rattus norvegicus	29-33
7997172-1	1994	Arginine biosynthesis in Escherichia coli is negatively regulated by a hexameric repressor protein, encoded by the gene argR and the corepressor arginine.	Arginine	0-8	arginine repressor	Escherichia coli	120-124
7527054-4	1994	Fibronectin contains at least three distinct peptide sequences that are active sites for alpha 4 beta 1 binding, two homologous sequences Leu-Asp-Val-Pro (LDVP) and Ile-Asp-Ala-Pro (IDAP), and a third related to Arg-Gly-Asp (RGD).	Arginine	212-215	fibronectin 1	Homo sapiens	0-11
8045974-0	1994	The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys.	Arginine	114-122	insulin	Homo sapiens	123-130
8045974-1	1994	To determine the effects of puberty and estrogen priming on the GH response to standardized treadmill exercise and arginine-insulin in normal boys and girls, we performed tests in 84 normal children (41 girls and 43 boys) representing all stages of puberty.	Arginine	115-123	insulin	Homo sapiens	124-131
7997172-1	1994	Arginine biosynthesis in Escherichia coli is negatively regulated by a hexameric repressor protein, encoded by the gene argR and the corepressor arginine.	Arginine	145-153	arginine repressor	Escherichia coli	120-124
7997173-1	1994	The Escherichia coli arginine repressor (ArgR) is an L-arginine-dependent DNA-binding protein that controls expression of the arginine biosynthetic genes and is required as an accessory protein in Xer site-specific recombination at cer and related recombination sites in plasmids.	Arginine	21-29	arginine repressor	Escherichia coli	41-45
7997173-1	1994	The Escherichia coli arginine repressor (ArgR) is an L-arginine-dependent DNA-binding protein that controls expression of the arginine biosynthetic genes and is required as an accessory protein in Xer site-specific recombination at cer and related recombination sites in plasmids.	Arginine	55-63	arginine repressor	Escherichia coli	41-45
7997173-2	1994	Site-directed mutagenesis was used to isolate two mutants of E. coli ArgR that were defective in arginine binding.	Arginine	97-105	arginine repressor	Escherichia coli	69-73
7537167-1	1994	The free radical nitric oxide (NO) is synthesized from the guanidino group of L-arginine by a family of enzymes termed NO synthase (NOS).	Arginine	78-88	nitric oxide synthase 2	Homo sapiens	119-130
7987211-4	1994	Ten noncontiguous amino acids from the structurally well-defined 4-helix core domain (amino acids 1-63) and the C-terminal arginine-containing tripeptide were found to contribute to the pharmacophore of human C5a.	Arginine	123-131	complement C5a receptor 1	Homo sapiens	209-212
7518445-1	1994	PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets.	Arginine	63-66	fibrinogen beta chain	Homo sapiens	93-103
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
7518462-3	1994	On an 11.5-kDa fragment of fibronectin that included the Arg-Gly-Asp (RGD) sequence, but not the synergy site, binding was reduced 50-fold.	Arginine	57-60	fibronectin 1	Homo sapiens	27-38
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	144-147	C-X-C motif chemokine ligand 8	Homo sapiens	210-214
8034699-6	1994	Our study shows that, besides the extracellular domain cysteines which may be critical for the overall folding of the receptor, three residues, Arg-199, Arg-203, and Asp-265, are important for IL-8 binding and IL-8-mediated signal transduction.	Arginine	153-156	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
8034598-4	1994	We report here that the glycine/arginine-rich domains of GAR1, which are shared by several other nucleolar proteins, are neither sufficient nor required for the steady-state accumulation of the fusion protein in the nucleolus.	Arginine	32-40	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	57-61
7524724-1	1994	Nitric oxide (NO), a short-lived, highly diffusible free radical, is a messenger molecule produced through the conversion of arginine to citrulline by NO synthase (NOS).	Arginine	125-133	nitric oxide synthase 2	Homo sapiens	151-162
8037675-3	1994	Ni2+ binds to a site in the N-terminal region of the protein which is partially blocked by the presence of a propeptide as in proalbumin (proAlb) Varese (Arg-2--&gt;His), proAlb Christchurch (Arg-1--&gt;Gln) and proAlb Blenheim (Asp1--&gt;Val) and by the presence of only an extra Arg residue (Arg-1) as in Arg-Alb and albumin (Alb) Redhill.	Arginine	154-157	albumin	Homo sapiens	141-144
8027055-0	1994	Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.	Arginine	102-110	coagulation factor II, thrombin	Homo sapiens	65-73
8027055-0	1994	Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.	Arginine	102-110	coagulation factor II, thrombin	Homo sapiens	124-132
8027055-0	1994	Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.	Arginine	156-164	coagulation factor II, thrombin	Homo sapiens	65-73
8027055-0	1994	Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.	Arginine	156-164	coagulation factor II, thrombin	Homo sapiens	124-132
8048578-6	1994	Endothelium-dependent relaxations to bradykinin and ET-1 were greater in pulmonary veins compared with arteries, inhibited by N omega-nitro-L-arginine, and reversed by L-arginine.	Arginine	140-150	kininogen 1	Homo sapiens	37-47
8048578-6	1994	Endothelium-dependent relaxations to bradykinin and ET-1 were greater in pulmonary veins compared with arteries, inhibited by N omega-nitro-L-arginine, and reversed by L-arginine.	Arginine	140-150	endothelin 1	Homo sapiens	52-56
8033424-2	1994	A cytokine-inducible high output L-arginine/nitric oxide pathway was recently detected in patients with advanced malignancy treated with IL-2.	Arginine	33-43	interleukin 2	Homo sapiens	137-141
7923965-6	1994	Plasma renin activity and urinary cGMP were significantly increased in response to arginine only in normals without captopril pretreatment.	Arginine	83-91	renin	Homo sapiens	7-12
7923965-8	1994	It was concluded that cGMP and glucagon are possible mediators for arginine-induced hyperfiltration and inhibition of renin-angiotensin system attenuates the arginine-induced rise in GFR.	Arginine	158-166	renin	Homo sapiens	118-123
7517798-9	1994	NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine.	Arginine	15-25	interleukin 1 beta	Rattus norvegicus	68-77
7959883-9	1994	Addition of L-arginine to IFN-gamma-stimulated macrophages in the presence of NgMMLA restored nitrite production and bacteriostatic activity of macrophages.	Arginine	12-22	interferon gamma	Mus musculus	26-35
8556479-1	1994	Substance P (SP) is an undecapeptide that has the amino sequence Arg-Pro-Lys-Pro-Gin-Gln-Phe-Phe-Gly-Leu-Met-NH2 and that belongs to a family of structurally related peptides known as tachykinins, the latter are widely distributed in the central nervous system.	Arginine	65-68	tachykinin precursor 1	Homo sapiens	0-11
8556479-1	1994	Substance P (SP) is an undecapeptide that has the amino sequence Arg-Pro-Lys-Pro-Gin-Gln-Phe-Phe-Gly-Leu-Met-NH2 and that belongs to a family of structurally related peptides known as tachykinins, the latter are widely distributed in the central nervous system.	Arginine	65-68	tachykinin precursor 1	Homo sapiens	13-15
7517876-2	1994	C5a is very rapidly degraded by serum carboxypeptidase N which cleaves the functionally important carboxy-terminal arginine, generating C5desarg, a chemotactic agonist with little mast cell-activating ability.	Arginine	115-123	complement C5a receptor 1	Homo sapiens	0-3
8207805-9	1994	In the ACH-2 cell line, which is now demonstrated to contain an endogenous mutant form of p53 (amino acid 248, Arg to Gln), additional mutant p53 proteins did not alter HIV-1 replication.	Arginine	111-114	tumor protein p53	Homo sapiens	90-93
8004673-4	1994	We have characterized patient-specific DHP receptor mutations in 11 probands of 33 independent hypoKPP kindreds that occur at one of two adjacent nucleotides within the same codon and predict substitution of a highly conserved arginine in the S4 segment of domain 4 with either histidine or glycine.	Arginine	227-235	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	39-51
8206928-0	1994	Internalization of the constitutively active arginine 1152--&gt;glutamine insulin receptor occurs independently of insulin at an accelerated rate.	Arginine	45-53	insulin	Homo sapiens	74-81
8202161-6	1994	The rad25 Arg-392 encoded product, which contains a mutation in the ATP-binding motif, is defective in RNA polymerase II transcription, suggesting that the RAD25-encoded DNA helicase functions in DNA duplex opening during transcription initiation.	Arginine	10-13	TFIIH/NER complex ATPase/helicase subunit SSL2	Saccharomyces cerevisiae S288C	4-9
8202161-6	1994	The rad25 Arg-392 encoded product, which contains a mutation in the ATP-binding motif, is defective in RNA polymerase II transcription, suggesting that the RAD25-encoded DNA helicase functions in DNA duplex opening during transcription initiation.	Arginine	10-13	TFIIH/NER complex ATPase/helicase subunit SSL2	Saccharomyces cerevisiae S288C	156-161
8075867-16	1994	In contrast, transport of arginine via the cationic amino acid system y+ is induced in J774 cells activated with LPS.7.	Arginine	26-34	toll-like receptor 4	Mus musculus	113-116
8023953-0	1994	Inhibition of C5a des Arg-induced neutrophil alveolitis in transgenic mice expressing C-reactive protein.	Arginine	22-25	hemolytic complement	Mus musculus	14-17
8023953-4	1994	After direct instillation of a known inflammatory agent (C5a des Arg) into the airways, transgenic mice with high plasma levels of CRP showed significantly diminished infiltration of neutrophils into bronchoalveolar lavage fluid (BALF) and a significant reduction of BALF total protein levels compared with normal mice.	Arginine	65-68	hemolytic complement	Mus musculus	57-60
8075312-5	1994	Like peptidomimetics based only on Arg (P1 of the natural substrate) or Arg analogues, these amino acid sequences also have been developed as active site directed inhibitors of thrombin and of factor Xa.	Arginine	35-38	coagulation factor II, thrombin	Homo sapiens	177-185
8075312-5	1994	Like peptidomimetics based only on Arg (P1 of the natural substrate) or Arg analogues, these amino acid sequences also have been developed as active site directed inhibitors of thrombin and of factor Xa.	Arginine	72-75	coagulation factor II, thrombin	Homo sapiens	177-185
8187062-2	1994	The cells carry only a mutated form of the p53 gene, the G--&gt;A mutation at codon 273 which results in an arginine to histidine substitution (mp53).	Arginine	108-116	tumor protein p53	Homo sapiens	43-46
8075622-9	1994	Interpreting this localisation together with information from the literature, the following functions are suggested during resorption: Osteocalcin may act as a chemoattractant for osteoclasts, while both osteopontin and bone sialoprotein may facilitate the binding of osteoclasts via the arg-gly-asp motif.	Arginine	288-291	bone gamma-carboxyglutamate protein	Homo sapiens	135-146
7930388-8	1994	IGF-I concentration evaluated 12, 24, and 48 h after arginine stimulation was significantly increased only in GR 2 patients (peak value: 0.95 +/- 0.1, p = 0.0003 vs baseline; GR 1: 0.34 +/- 0.05 U/ml).	Arginine	53-61	insulin like growth factor 1	Homo sapiens	0-5
8200045-6	1994	These findings suggest that NMA, an inhibitor of the L-arginine metabolic pathway, may regulate the production of specific C-X-C chemokines, IL-8 and ENA-78, during a MLR.	Arginine	53-63	C-X-C motif chemokine ligand 8	Homo sapiens	141-145
8033372-0	1994	Interaction of salbutamol with pyridostigmine and arginine on both basal and GHRH-stimulated GH secretion in humans.	Arginine	50-58	growth hormone releasing hormone	Homo sapiens	77-81
8033372-9	1994	ARG enhanced the GHRH-induced GH rise (P &lt; 0.01) but its effect was abolished (P &lt; 0.02) by SAL pretreatment.	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	17-21
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Arginine	187-195	androgen receptor	Homo sapiens	45-62
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Arginine	187-195	catalase	Homo sapiens	216-219
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Arginine	187-195	androgen receptor	Homo sapiens	285-302
8187090-5	1994	Another case showed a CGA (Arg) to GGA (Gly) mutation in codon 201, which might be a polymorphic change, and two other mutations resulting in no amino acid change.	Arginine	27-30	chromogranin A	Homo sapiens	22-25
8084436-5	1994	The results, or in other words the comparison between the two groups, basal or after treatment, and the values recorded before and after treatment in each group, enable the authors to affirm that the administration of the arginine-lysine-glycerophosphoric acid-lactose association leads to an increase in bone density and plasma osteocalcin, a reduction in painful symptoms and analgesic intake, and a reduction in the serum levels of parathromone and hydroxyproline.	Arginine	222-230	bone gamma-carboxyglutamate protein	Homo sapiens	329-340
7514680-7	1994	Except for the MAR mutation Cys--&gt;Arg at position 792, which abolished binding of all MAbs of domains A and D, amino acid substitutions affected only MAbs belonging to the same domain as the MAb used to select the MAR mutant.	Arginine	37-40	interferon regulatory factor 1	Homo sapiens	15-18
7969202-0	1994	Application of PCR site-directed mutagenesis for a rapid and accurate detection of mutation 3500 (Arg--&gt;Gln) of human apolipoprotein B-100.	Arginine	98-101	apolipoprotein B	Homo sapiens	121-141
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Arginine	124-127	von Willebrand factor	Homo sapiens	63-66
7519349-2	1994	The effect of two amphiphiles, lysophosphatidylcholine (LPC) and digitonin on the activity of nitric oxide synthase (NOS), as measured by conversion of radiolabeled L-arginine to L-citrulline, has been studied.	Arginine	165-175	nitric oxide synthase 2	Homo sapiens	94-115
7974349-6	1994	The epitopes of MAb 505 and MAb 400, which inhibit the binding of vWF to collagen, were identified between Leu 927 and Arg 1114 within the SPI fragment (aa 911-1365) corresponding to the central part of the vWF subunit.	Arginine	119-122	von Willebrand factor	Homo sapiens	66-69
8206611-4	1994	Prazosin, hydralazine, or L-arginine added to the drinking water all lowered the angiotensin II-induced increase in blood pressure but did not attenuate the increase in fibronectin mRNA expression.	Arginine	26-36	angiotensinogen	Rattus norvegicus	81-95
8168934-5	1994	We propose that the portion of the first N-terminal extracellular loop of the FMLP receptor containing residues Arg-84 and Lys-85 contributes significantly to the active site in ligand-receptor binding.	Arginine	112-115	formyl peptide receptor 1	Homo sapiens	78-91
7515050-1	1994	Nitric oxide synthase (NOS) catalyzes the NADPH-dependent, Ca2+/calmodulin-dependent formation of NO and citrulline from L-arginine and molecular oxygen.	Arginine	121-131	nitric oxide synthase 2	Homo sapiens	0-21
7515050-1	1994	Nitric oxide synthase (NOS) catalyzes the NADPH-dependent, Ca2+/calmodulin-dependent formation of NO and citrulline from L-arginine and molecular oxygen.	Arginine	121-131	calmodulin 1	Homo sapiens	64-74
7514170-11	1994	Together, these results demonstrate that both exogenous and endogenous NO inhibit IDO activity and that oxidative arginine and tryptophan metabolism in IFN gamma-primed mononuclear phagocytes are functionally related.	Arginine	114-122	interferon gamma	Homo sapiens	152-161
7513946-5	1994	Patient 2 was homozygous for a G-to-C substitution at codon 39, changing an encoded arginine (CGA) to proline (CCA).	Arginine	84-92	chromogranin A	Homo sapiens	94-97
7520724-3	1994	These patients were demonstrated to possess point mutations resulting in glycine-->arginine substitutions within the triple helical domain of the alpha 1(I) or alpha 2(I) collagen polypeptide chain.	Arginine	83-91	collagen type I alpha 2 chain	Homo sapiens	146-179
7520724-6	1994	Both defects were informative in that they identified the regions of the alpha 1(I) and alpha 2(I) collagen chains in which the phenotypes associated with glycine-->arginine substitutions undergo a transition between lethal and nonlethal forms, thereby allowing a more reliable prognosis of disease severity.	Arginine	165-173	collagen type I alpha 2 chain	Homo sapiens	73-107
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Arginine	155-165	interferon gamma	Homo sapiens	20-29
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Arginine	155-165	tumor necrosis factor	Homo sapiens	46-49
7514193-3	1994	24-h treatment with IFN-gamma (200 U/ml) plus TNF (200 U/ml) or IL-1 beta (5 U/ml) increased NOS activity in HUVEC lysates, measured as conversion of [14C]L-arginine to [14C]L-citrulline.	Arginine	155-165	interleukin 1 beta	Homo sapiens	64-73
7513741-6	1994	Removal of the C-terminal arginine from C3a and C5a abolished their activity on skin mast cells.	Arginine	26-34	complement C5a receptor 1	Homo sapiens	48-51
8182347-2	1994	This pathway involves the oxidation of arginine to citrulline, with the concomitant release of NO by an inducible form of NO synthase (iNOS).	Arginine	39-47	nitric oxide synthase 2	Homo sapiens	135-139
8072247-3	1994	Administration of L-arginine decreased the renal infiltration by macrophages in rats with PAN (P &lt; 0.0001) or BUO (P &lt; 0.0001) compared to rats with PAN or BUO given tap water alone.	Arginine	18-28	nuclear RNA export factor 1	Rattus norvegicus	172-175
7511942-2	1994	NO is synthesized from one of the guanidino nitrogens of L-arginine by the enzyme nitric oxide synthase (NOS).	Arginine	57-67	nitric oxide synthase 2	Homo sapiens	82-103
8175969-0	1994	Chronic baclofen therapy improves the blunted growth hormone response to intravenous arginine in subjects with spinal cord injury.	Arginine	85-93	growth hormone 1	Homo sapiens	46-60
8072247-7	1994	Random migration of peritoneal macrophages obtained from rats with urethral obstruction given L-arginine prior to obstruction was significantly lower than that of peritoneal macrophages obtained from similar rats given tap water alone prior to obstruction.	Arginine	94-104	nuclear RNA export factor 1	Rattus norvegicus	219-222
7513610-6	1994	In cell adhesion assays, the 69-6-5 mAb was able to inhibit strongly in a dose-dependent manner arginine-glycine-aspartic acid-mediated adhesion of HT29-D4 cells to vitronectin, fibronectin, or ProNectin F but not to laminin or collagen.	Arginine	96-104	fibronectin 1	Homo sapiens	178-189
7511667-5	1994	Mouse peritoneal macrophages cultured in the presence of IFN-gamma alone or IFN-gamma plus LPS rapidly depleted the medium of L-arginine, a substrate for iNOS, and stopped producing NO.	Arginine	126-136	interferon gamma	Mus musculus	57-66
8061610-15	1994	Inspection of the 3-dimensional structure of trypanosomal triosephosphate isomerase, which has a methionine at position 122, only increased the mystery of the effects of the Gly to Arg mutation in the human enzyme.	Arginine	181-184	triosephosphate isomerase 1	Homo sapiens	58-83
8066083-0	1994	The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.	Arginine	12-20	superoxide dismutase 1	Homo sapiens	64-90
8066083-14	1994	Results from this joint analysis establish that, aside from the Cu ligands, Arg-143 is the single most important residue in Cu,Zn superoxide dismutase both electrostatically and mechanistically, and provide an explanation for the evolutionary selection of arginine at position 143.	Arginine	76-79	superoxide dismutase 1	Homo sapiens	124-150
7513691-0	1994	Glutamate receptors induce a burst of superoxide via activation of nitric oxide synthase in arginine-depleted neurons.	Arginine	92-100	nitric oxide synthase 2	Homo sapiens	67-88
7511667-5	1994	Mouse peritoneal macrophages cultured in the presence of IFN-gamma alone or IFN-gamma plus LPS rapidly depleted the medium of L-arginine, a substrate for iNOS, and stopped producing NO.	Arginine	126-136	nitric oxide synthase 2, inducible	Mus musculus	154-158
7511667-6	1994	Repletion of L-arginine permitted cells treated with IFN-gamma alone to resume NO production for at least 5 days, leading to the release of more NO than macrophages were previously believed capable of generating.	Arginine	13-23	interferon gamma	Mus musculus	53-62
8174105-4	1994	We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg--&gt;Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity.	Arginine	103-106	tumor protein p53	Homo sapiens	81-84
7511667-7	1994	L-Arginine repletion also boosted NO production by macrophages cultured for up to 2 to 3 days in the presence of IFN-gamma plus LPS, but thereafter, iNOS was inactive in these cells whether or not L-arginine was repleted.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	149-153
7511667-8	1994	Activity of iNOS could be restored by adding both L-arginine and fresh IFN-gamma with or without LPS, likely reflecting the synthesis of new enzyme.	Arginine	50-60	nitric oxide synthase 2, inducible	Mus musculus	12-16
8157662-6	1994	When immobilized on nitrocellulose, the amino-terminal domain of LBR also associates with DNA, and the stretch between amino acids 71 and 100, which contains the Ser-Arg-rich stretch, is necessary for DNA binding.	Arginine	166-169	lamin B receptor	Homo sapiens	65-68
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Arginine	126-129	pyruvate kinase L/R	Homo sapiens	51-60
8142399-14	1994	The P1 Arg and Lys mutants also significantly inhibited thrombin, factor XIa, activated protein C, plasmin, factor XIIa, kallikrein, and bovine trypsin and chymotrypsin but did not inhibit tissue factor.factor VIIa, t-PA, or HLE.	Arginine	7-10	plasminogen activator, tissue type	Bos taurus	216-220
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Arginine	126-129	pyruvate kinase L/R	Homo sapiens	62-66
8161798-3	1994	1436 from the translational initiation site of the R-type PK (R-PK) mRNA, and it caused a single amino acid substitution from Arg to His at the 479th amino acid residue of the R-PK.	Arginine	126-129	pyruvate kinase L/R	Homo sapiens	176-180
8174105-4	1994	We report here that p53-deficient hepatoma cells (Hep3B) transfected with mutant p53-249ser (codon 249 Arg--&gt;Ser) acquire a new phenotype with an increased in vitro survival and mitotic activity.	Arginine	103-106	tumor protein p53	Homo sapiens	20-23
7511609-2	1994	Fibronectin (Fn) binding to the integrins alpha IIb beta 3 and alpha v beta 3 involves the Arg-Gly-Asp sequence.	Arginine	91-94	fibronectin 1	Homo sapiens	0-11
8054455-7	1994	This mutation results in the amino acid substitution Arg--&gt;His at position 16 of the A alpha chain, the site of thrombin cleavage.	Arginine	53-56	coagulation factor II, thrombin	Homo sapiens	115-123
7514363-4	1994	IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective.	Arginine	111-121	interleukin 1 beta	Rattus norvegicus	0-9
7514363-4	1994	IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective.	Arginine	111-121	tumor necrosis factor	Rattus norvegicus	11-20
8037358-5	1994	We found that allergen challenge in the allergic subjects induced nasal symptoms concomitantly with increased levels of C3a des Arg and C5a des Arg (P &lt; 0.05).	Arginine	144-147	complement C5a receptor 1	Homo sapiens	136-139
7511593-10	1994	Taken together, these results suggest that the sequential exposure of monocytes to IFN-gamma and IL-4 elicits the release of NO from L-arginine, which in turn is capable to stimulate soluble guanylyl cyclase.	Arginine	133-143	interferon gamma	Homo sapiens	83-92
7908608-10	1994	The p53 arginine allele was found to be more common in Caucasians (0.71) than African-Americans (0.50).	Arginine	8-16	tumor protein p53	Homo sapiens	4-7
7909256-1	1994	Direct sequencing showed a G-A point mutation at position 2818 of exon 7, which was responsible for an arginine-histidine substitution at position 840 of the androgen receptor.	Arginine	103-111	androgen receptor	Homo sapiens	158-175
7511585-3	1994	While citrulline has been considered to be an inert by-product of the high output inducible isoform of NO synthase (iNOS), we show here that immunostimulants induce a metabolic pathway in vascular smooth muscle cells, which enables them to regenerate arginine from citrulline.	Arginine	251-259	nitric oxide synthase 2	Homo sapiens	116-120
8070905-0	1994	Gc globulin (vitamin D-binding protein) increases binding of low concentrations of C5a des Arg to human polymorphonuclear leukocytes: an explanation for its cochemotaxin activity.	Arginine	91-94	complement C5a receptor 1	Homo sapiens	83-86
8070905-1	1994	The chemotactic activity of native human C5a des Arg is enhanced significantly by the normal serum and plasma protein Gc globulin (vitamin D-binding protein).	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
8070905-2	1994	Gc globulin attaches to sialic acid residues within the oligosaccharide chain of C5a des Arg to form a complex with potent chemotactic activity for human PMN.	Arginine	89-92	complement C5a receptor 1	Homo sapiens	81-84
8070905-3	1994	We investigated the mechanism whereby this phenomenon may occur and found that Gc globulin enhanced the binding of low concentrations of [125I]C5a des Arg to PMN, but had no effect on C5a-induced displacement of bound [125]C5a des Arg.	Arginine	151-154	complement C5a receptor 1	Homo sapiens	143-146
8070905-3	1994	We investigated the mechanism whereby this phenomenon may occur and found that Gc globulin enhanced the binding of low concentrations of [125I]C5a des Arg to PMN, but had no effect on C5a-induced displacement of bound [125]C5a des Arg.	Arginine	231-234	complement C5a receptor 1	Homo sapiens	143-146
8070905-4	1994	Gc globulin bound to PMN, and probably acted as a C5a des Arg chaperon.	Arginine	58-61	complement C5a receptor 1	Homo sapiens	50-53
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	60-63	complement C5a receptor 1	Homo sapiens	52-55
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	60-63	complement C5a receptor 1	Homo sapiens	89-92
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	97-100	complement C5a receptor 1	Homo sapiens	52-55
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	97-100	complement C5a receptor 1	Homo sapiens	89-92
8070905-6	1994	This phenomenon provides a plausible explanation for the enhancing effect of Gc globulin on the chemotactic activity of low concentrations of native human C5a des Arg.	Arginine	163-166	complement C5a receptor 1	Homo sapiens	155-158
7511593-10	1994	Taken together, these results suggest that the sequential exposure of monocytes to IFN-gamma and IL-4 elicits the release of NO from L-arginine, which in turn is capable to stimulate soluble guanylyl cyclase.	Arginine	133-143	interleukin 4	Homo sapiens	97-101
7516884-8	1994	The similarity in the inhibitory effects of N omega-nitro-L-arginine methyl ester and N omega-nitro-L-arginine on responses to acetylcholine, bradykinin, and substance P suggest that the L-arginine analog, N omega-nitro-L-arginine, as well as the methyl ester of N omega-nitro-L-arginine, are useful probes for studying endothelium-dependent vasodilator responses in the mesenteric vascular bed of the cat.	Arginine	58-68	kininogen 1	Homo sapiens	142-152
7516884-8	1994	The similarity in the inhibitory effects of N omega-nitro-L-arginine methyl ester and N omega-nitro-L-arginine on responses to acetylcholine, bradykinin, and substance P suggest that the L-arginine analog, N omega-nitro-L-arginine, as well as the methyl ester of N omega-nitro-L-arginine, are useful probes for studying endothelium-dependent vasodilator responses in the mesenteric vascular bed of the cat.	Arginine	58-68	tachykinin precursor 1	Homo sapiens	158-169
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	135-138	vasoactive intestinal polypeptide	Mus musculus	76-79
8073392-2	1994	For most of these proteins, the sequences around the cleavage sites show a common motif (Arg-X-Lys/Arg-Arg) which define the substrate specificity for the endoprotease furin/PACE of the Golgi apparatus.	Arginine	89-92	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	168-173
8073392-2	1994	For most of these proteins, the sequences around the cleavage sites show a common motif (Arg-X-Lys/Arg-Arg) which define the substrate specificity for the endoprotease furin/PACE of the Golgi apparatus.	Arginine	89-92	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	174-178
8073392-2	1994	For most of these proteins, the sequences around the cleavage sites show a common motif (Arg-X-Lys/Arg-Arg) which define the substrate specificity for the endoprotease furin/PACE of the Golgi apparatus.	Arginine	99-102	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	168-173
8073392-2	1994	For most of these proteins, the sequences around the cleavage sites show a common motif (Arg-X-Lys/Arg-Arg) which define the substrate specificity for the endoprotease furin/PACE of the Golgi apparatus.	Arginine	99-102	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	174-178
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	135-138	vasoactive intestinal polypeptide	Mus musculus	295-298
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	135-138	vasoactive intestinal polypeptide	Mus musculus	295-298
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	146-149	vasoactive intestinal polypeptide	Mus musculus	76-79
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	146-149	vasoactive intestinal polypeptide	Mus musculus	76-79
8117736-2	1994	Tat uses a single arginine residue within a short region of basic amino acids to recognize a bulge region in TAR.	Arginine	18-26	RNA binding motif protein 8A	Homo sapiens	109-112
8156744-4	1994	The proband, a 51-year-old Caucasian male, was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly) and his spouse was a carrier of APOE*2(Val-236--&gt;Glu).	Arginine	80-83	apolipoprotein E	Homo sapiens	60-66
7509810-1	1994	Nitric oxide, a multifunctional effector molecule synthesized by nitric oxide synthase (NOS) from L-arginine, conveys signals for vasorelaxation, neurotransmission, and cytotoxicity.	Arginine	98-108	nitric oxide synthase 2	Homo sapiens	65-86
7923409-2	1994	This strain, VC32, carries a mutation in the mitochondrial COX2 gene which converts a conserved glycine residue to arginine.	Arginine	115-123	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	59-63
8120012-4	1994	The cleavage site of the signal sequence in nodulin-24 was determined to be between Ala (A25) and Arg (R26) by microsequencing of the [3H]leucine-labeled processed peptide.	Arginine	98-101	nodulin-24	Glycine max	44-54
8079812-0	1994	Differential sensitivity to Arg side chain modification of IL-1 beta binding to type I and type II receptors.	Arginine	28-31	interleukin 1 beta	Homo sapiens	59-68
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	12-20	interleukin 1 beta	Homo sapiens	45-54
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	22-25	interleukin 1 beta	Homo sapiens	45-54
8079812-2	1994	The role of arginine (Arg) side chains of hr-IL-1 beta in receptor recognition was studied by the modification of Arg residues with the specific reagent 1,2-cyclohexanedione.	Arginine	114-117	interleukin 1 beta	Homo sapiens	45-54
8079812-3	1994	It was found that chemical modification of Arg residues decreased the binding potential of IL-1 beta to type I receptor dramatically (by 230-fold) while the affinity to type II receptor was reduced only moderately (by 10-fold), with an insignificant reduction of the dissociation rate.	Arginine	43-46	interleukin 1 beta	Homo sapiens	91-100
8079812-4	1994	These studies suggest that intact Arg side chains of IL-1 beta may be necessary for high affinity binding to type I IL-1 receptor, but have less importance for the interaction of IL-1 beta with type II IL-1 receptor.	Arginine	34-37	interleukin 1 beta	Homo sapiens	53-62
8156744-8	1994	The plasma triacylglycerol concentration was moderately increased in a sister, who was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly), and in the son, who was a compound heterozygote for both mutant APOE alleles.	Arginine	120-123	apolipoprotein E	Homo sapiens	100-106
8156744-8	1994	The plasma triacylglycerol concentration was moderately increased in a sister, who was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly), and in the son, who was a compound heterozygote for both mutant APOE alleles.	Arginine	120-123	apolipoprotein E	Homo sapiens	100-104
8156744-8	1994	The plasma triacylglycerol concentration was moderately increased in a sister, who was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly), and in the son, who was a compound heterozygote for both mutant APOE alleles.	Arginine	125-128	apolipoprotein E	Homo sapiens	100-106
8156744-8	1994	The plasma triacylglycerol concentration was moderately increased in a sister, who was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly), and in the son, who was a compound heterozygote for both mutant APOE alleles.	Arginine	125-128	apolipoprotein E	Homo sapiens	100-104
8156744-4	1994	The proband, a 51-year-old Caucasian male, was a carrier of APOE*3(Cys-112--&gt;Arg; Arg-251--&gt;Gly) and his spouse was a carrier of APOE*2(Val-236--&gt;Glu).	Arginine	85-88	apolipoprotein E	Homo sapiens	60-66
8005563-5	1994	The GH response to arginine infusion was significantly inhibited by PZ at high dose (AUC, 147.1 +/- 48.8 vs 444.7 +/- 194.3 micrograms/L/h, p &lt; 0.01), but not at low dose.	Arginine	19-27	growth hormone 1	Homo sapiens	4-6
8005564-0	1994	Blunted growth hormone response to intravenous arginine in subjects with a spinal cord injury.	Arginine	47-55	growth hormone 1	Homo sapiens	8-22
8051337-0	1994	Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration.	Arginine	0-8	growth hormone 1	Homo sapiens	22-36
8011979-6	1994	However, by 15 to 16 wk postnephrectomy, values of glomerular capillary pressure and efferent arteriolar resistance were significantly greater and the glomerular capillary ultrafiltration coefficient was significantly lower in rats drinking tap water than in rats drinking tap water supplemented with L-arginine.	Arginine	301-311	nuclear RNA export factor 1	Rattus norvegicus	241-244
8126161-8	1994	DNA sequence predicting a His for Arg substitution at Gs alpha amino acid 201 was found in 47% of the recombinant plasmids from DNA of affected bone and 17% of the plasmids from DNA of unaffected bone; a significant (P &lt; 0.05) difference in frequency.	Arginine	34-37	GNAS complex locus	Homo sapiens	54-62
7907341-2	1994	DNA sequence analysis of a polymerase chain reaction-amplified portion of the proband"s apo-E gene revealed the substitution of cysteine (TGC) for arginine (CGC) at position 136 in the mutant allele (designated R136C).	Arginine	147-155	apolipoprotein E	Homo sapiens	88-93
8051337-2	1994	On the other hand, it has been shown that arginine (ARG) totally restores the reduced somatotropic responsiveness to GHRH observed in aging.	Arginine	42-50	growth hormone releasing hormone	Homo sapiens	117-121
8051337-2	1994	On the other hand, it has been shown that arginine (ARG) totally restores the reduced somatotropic responsiveness to GHRH observed in aging.	Arginine	52-55	growth hormone releasing hormone	Homo sapiens	117-121
8133041-8	1994	This C-terminal acidic amino acid may interact with an arginine residue in the MHC class II alpha-chain that is exposed when beta-chain residue 57 is mutated to serine, or to the unique beta-chain residue histidine 56.	Arginine	55-63	histocompatibility 2, class II antigen E alpha	Mus musculus	79-103
8119968-3	1994	Using site-directed mutagenesis, we have introduced furin consensus cleavage sequences (Arg-X-Lys-Arg) into the human proinsulin cDNA.	Arginine	88-91	insulin	Homo sapiens	118-128
8139489-0	1994	Insulin production following intravenous glucose, arginine, and valine: different pattern in patients with impaired glucose tolerance and non-insulin-dependent diabetes mellitus.	Arginine	50-58	insulin	Homo sapiens	0-7
7912599-0	1994	Regeneration of catalytic activity of glutamine synthetase mutants by chemical activation: exploration of the role of arginines 339 and 359 in activity.	Arginine	118-127	glutamate-ammonia ligase	Homo sapiens	38-58
7998345-0	1994	[Effect of chemical modification of arginine residues of fibrinogen and its DH-fragment on the rate of hydrolysis of these proteins by plasminogen].	Arginine	36-44	fibrinogen beta chain	Homo sapiens	57-67
7998345-1	1994	Plasminolysis of the fibrinogen arginine and its DH-fragment residues was sufficiently lower in contrast to that of initial proteins.	Arginine	32-40	fibrinogen beta chain	Homo sapiens	21-31
8133057-9	1994	These results indicate that chemotaxis of PMNs in response to TGF-beta isoforms is mediated by the interaction of the Arg-gly-Asp-ser sequence in the CBD of Fn with an integrin on the PMN cell surface, primarily the VLA-5 integrin.	Arginine	118-121	transforming growth factor beta 1	Homo sapiens	62-70
8133057-9	1994	These results indicate that chemotaxis of PMNs in response to TGF-beta isoforms is mediated by the interaction of the Arg-gly-Asp-ser sequence in the CBD of Fn with an integrin on the PMN cell surface, primarily the VLA-5 integrin.	Arginine	118-121	integrin subunit alpha 5	Homo sapiens	216-221
8145543-2	1994	We were particularly interested in the relationship of TNF-alpha binding characteristics to various known neutrophil-priming stimuli such as temperature, N-formylmethionyl-leucyl-phenylalanine (fMLP), phorbol myristate acetate (PMA), C5ades Arg, and human recombinant C5a (HrC5a).	Arginine	241-244	tumor necrosis factor	Homo sapiens	55-64
8119968-3	1994	Using site-directed mutagenesis, we have introduced furin consensus cleavage sequences (Arg-X-Lys-Arg) into the human proinsulin cDNA.	Arginine	98-101	insulin	Homo sapiens	118-128
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Arginine	56-59	eukaryotic translation elongation factor 2	Rattus norvegicus	148-167
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	Arginine	205-213	interleukin 1 beta	Mus musculus	43-90
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	Arginine	205-213	interferon gamma	Mus musculus	96-112
8117099-9	1994	The N-terminal sequence Val-Asn-Phe-Thr-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, was identical to the N-terminal sequence of human, hamster and rat elongation factor 2 (EF-2).	Arginine	56-59	eukaryotic translation elongation factor 2	Rattus norvegicus	169-173
8148419-0	1994	Hb Cemenelum [alpha 92 (FG4) Arg-->Trp]: a hemoglobin variant of the alpha 1/beta 2 interface that displays a moderate increase in oxygen affinity.	Arginine	29-32	BCL2 related protein A1	Homo sapiens	69-83
8308036-4	1994	Transient expression of an inactive point mutant (nPKC epsilon K--&gt;R) of nPKC epsilon, where Lys436 at the putative ATP-binding site is replaced with Arg, also confers elevated binding activity.	Arginine	153-156	protein kinase C, epsilon	Rattus norvegicus	50-62
8308036-4	1994	Transient expression of an inactive point mutant (nPKC epsilon K--&gt;R) of nPKC epsilon, where Lys436 at the putative ATP-binding site is replaced with Arg, also confers elevated binding activity.	Arginine	153-156	protein kinase C, epsilon	Rattus norvegicus	76-88
8208902-4	1994	Sequencing of the apoAI gene demonstrated that the proband was a heterozygote for a single base substitution in exon 3, changing codon 26 from GGC(Gly) to CGC(Arg).	Arginine	159-162	apolipoprotein A1	Homo sapiens	18-23
8112314-9	1994	The same residues that were found to control binding of Tosyl-Gly-Pro-Arg-NH-Ph to alpha-thrombin, do modulate binding of fibrinogen as well.	Arginine	70-73	coagulation factor II, thrombin	Homo sapiens	89-97
8121306-0	1994	Interaction of free fatty acids and arginine on growth hormone secretion in man.	Arginine	36-44	growth hormone 1	Homo sapiens	48-62
8121306-5	1994	Moreover, the lipid-heparin infusion inhibited the potentiating effect of ARG on the GHRH-induced GH increase (527.9 +/- 113.6 v 2,009.9 +/- 463.2 micrograms/L/h, P &lt; .01).	Arginine	74-77	growth hormone 1	Homo sapiens	85-87
8121306-6	1994	These results confirm the strong inhibitory effect of FFAs on GH secretion, showing that they are even able to inhibit the potentiating effect of ARG on the GH response to GHRH.	Arginine	146-149	growth hormone 1	Homo sapiens	62-64
8112732-5	1994	In four out of the five patients, heterozygous germline mutations were found: a novel point mutation in exon 8 (ZF2) at codon 377 altering the wild-type histidine to arginine, and three previously described point mutations in exon 9 (ZF3) in the codons corresponding to amino acids 394Arg and 396Asp.	Arginine	166-174	zinc finger protein 274	Homo sapiens	112-115
8006330-0	1994	Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.	Arginine	57-65	growth hormone 1	Homo sapiens	86-100
8006330-0	1994	Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects.	Arginine	57-65	growth hormone releasing hormone	Homo sapiens	113-145
8006330-4	1994	ARG strikingly enhanced the GHRH-induced GH rise (peak, mean +/- SE: 41.5 +/- 4.4 vs 11.7 +/- 5.3 micrograms/L, p &lt; 0.05).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	28-32
8006330-6	1994	and 8 g oral ARG enhanced the GH response to GHRH (20.9 +/- 4.7 vs 8.3 +/- 2.8 micrograms/L, p &lt; 0.03 and 31.0 +/- 5.3 vs 11.4 +/- 3.4 micrograms/L, p &lt; 0.03, respectively).	Arginine	13-16	growth hormone releasing hormone	Homo sapiens	45-49
8121306-6	1994	These results confirm the strong inhibitory effect of FFAs on GH secretion, showing that they are even able to inhibit the potentiating effect of ARG on the GH response to GHRH.	Arginine	146-149	growth hormone 1	Homo sapiens	157-159
8121306-6	1994	These results confirm the strong inhibitory effect of FFAs on GH secretion, showing that they are even able to inhibit the potentiating effect of ARG on the GH response to GHRH.	Arginine	146-149	growth hormone releasing hormone	Homo sapiens	172-176
8121306-7	1994	Since ARG likely acts via inhibition of hypothalamic somatostatin release, the inhibitory effect of FFAs on GH secretion could take place directly at the pituitary level and/or at the hypothalamic level, counteracting the effect of ARG.	Arginine	232-235	growth hormone 1	Homo sapiens	108-110
8121306-4	1994	GHRH-induced GH secretion was potentiated by ARG (2,009.9 +/- 463.2 v 922.0 +/- 244.4 micrograms/L/h, P &lt; .05) and suppressed by lipid-heparin infusion (106.2 +/- 28.3 v 922.0 +/- 244.4 micrograms/L/h, P &lt; .01).	Arginine	45-48	growth hormone releasing hormone	Homo sapiens	0-4
8121306-4	1994	GHRH-induced GH secretion was potentiated by ARG (2,009.9 +/- 463.2 v 922.0 +/- 244.4 micrograms/L/h, P &lt; .05) and suppressed by lipid-heparin infusion (106.2 +/- 28.3 v 922.0 +/- 244.4 micrograms/L/h, P &lt; .01).	Arginine	45-48	growth hormone 1	Homo sapiens	0-2
8121306-5	1994	Moreover, the lipid-heparin infusion inhibited the potentiating effect of ARG on the GHRH-induced GH increase (527.9 +/- 113.6 v 2,009.9 +/- 463.2 micrograms/L/h, P &lt; .01).	Arginine	74-77	growth hormone releasing hormone	Homo sapiens	85-89
7508382-12	1994	In particular while the latter enzyme is especially active toward a number of phosphopeptides reproducing the phosphoacceptor sites of src products and of calmodulin whose N-terminal moieties are predominantly acidic, the artificial substrate phospho-angiotensin II, bearing an arginine residue at position -2, is far preferred by calcineurin over all phosphotyrosyl peptides of similar size.	Arginine	278-286	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	135-138
8294474-3	1994	The amino acid sequences of radioactive peptides resulting from the reaction of aldose reductase with [14C]phenylglyoxal followed by tryptic digestion and high performance liquid chromatography separation allowed identification of the modified arginine residues as R268 and R293.	Arginine	244-252	aldo-keto reductase family 1 member B	Sus scrofa	80-96
8294474-5	1994	Phenylglyoxal modification of aldose reductase is slowed 3-fold by the presence of the coenzyme analog ADPRP; however, both arginines are still modified.	Arginine	124-133	aldo-keto reductase family 1 member B	Sus scrofa	30-46
8294474-2	1994	Reaction of pig muscle aldose reductase with phenylglyoxal resulted in the chemical modification of 2 arginine residues with accompanying loss of catalytic activity.	Arginine	102-110	aldo-keto reductase family 1 member B	Sus scrofa	23-39
7508382-12	1994	In particular while the latter enzyme is especially active toward a number of phosphopeptides reproducing the phosphoacceptor sites of src products and of calmodulin whose N-terminal moieties are predominantly acidic, the artificial substrate phospho-angiotensin II, bearing an arginine residue at position -2, is far preferred by calcineurin over all phosphotyrosyl peptides of similar size.	Arginine	278-286	calmodulin 1	Homo sapiens	155-165
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	229-232	coagulation factor II, thrombin	Homo sapiens	107-115
7507106-4	1994	The present study demonstrates that lipopolysaccharide and interferon-gamma, which induce NOS in the murine macrophage cell line RAW 264.7, also coinduce activity and mRNA for argininosuccinate synthetase, which is limiting for arginine synthesis.	Arginine	228-236	interferon gamma	Mus musculus	59-75
8292014-3	1994	Furthermore, the 13 N-terminal amino acid sequence of the 100-kDa protein, N-Val-Asn-Phe-Val-Asp-Gln-Ile-Arg-Ala-Ile-Met-Asp-Lys, exactly matches with that of elongation factor-2 from rat and hamster.	Arginine	105-108	eukaryotic translation elongation factor 2	Rattus norvegicus	159-178
8307029-1	1994	The Saccharomyces cerevisiae KEX1 gene encodes a carboxypeptidase involved in the C-terminal processing of the lysine and arginine residues from the precursors of K1 and K2 killer toxins and alpha-factor (mating pheromone).	Arginine	122-130	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	29-33
8307029-11	1994	Insect-cell-derived Kex1 delta p processes alpha-factor-Lys-Arg, a known natural substrate, to mature active alpha-factor in a manner similar to the membrane-associated full-length enzyme.	Arginine	60-63	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	20-24
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Arginine	19-22	coagulation factor II, thrombin	Homo sapiens	61-69
8288594-2	1994	Point mutations at Arg-180, Arg-245, Lys-248, and Lys-252 in thrombin markedly reduced the efficiency of heparin catalysis by decreasing the stability of the ternary intermediate, whereas the inactivation of thrombin by antithrombin alone was not affected by these mutations.	Arginine	28-31	coagulation factor II, thrombin	Homo sapiens	61-69
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	229-232	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	229-232	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	74-82
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8288594-3	1994	These results together with an analysis of the x-ray crystal structure of thrombin yielded a model for the thrombin-heparin interaction, wherein heparin forms salt linkages along a groove in thrombin defined by Lys-252, Lys-248, Arg-245, Arg-89, Arg-98, and Arg-180.	Arginine	238-241	coagulation factor II, thrombin	Homo sapiens	107-115
8110876-4	1994	p53 mutations were restricted to one case of myeloid blast crisis, showing a CGC--&gt;TGC (Arg--&gt;Cys) mutation at codon 283; two additional cases displayed LOH at 17p13 in the absence of p53 mutations.	Arginine	91-94	tumor protein p53	Homo sapiens	0-3
8280781-3	1994	The biochemical characterization of the variants and the kinetic study of thrombin and activated factor X (F Xa) inhibition in the presence of heparin and heparin derivatives suggest that Arg-129 plays a specific role in AT conformation and F Xa inhibition enhancement.	Arginine	188-191	coagulation factor II, thrombin	Homo sapiens	74-82
7976184-2	1994	NO is generated enzymatically from L-arginine by a constitutive, cytosolic, Ca2+/calmodulin-activated NO synthase (NOS): NADPH- and tetrahydrobiopterin-dependent cytochrome P-450-type hemoprotein.	Arginine	35-45	nitric oxide synthase 2	Homo sapiens	102-113
7866721-16	1994	In order to control the autoactivation process point mutant cDNAs were constructed by altering the Arg-Ile bond in the catalytic domain of the C1r.	Arginine	99-102	complement C1r	Homo sapiens	143-146
8193484-4	1994	In the other four subjects, growth hormone production was measured by growth hormone pharmacological stimulation tests (clonidine, arginine): three of four patients had insufficient growth hormone responses (peak growth hormone &lt; 10 micrograms/l); all three had delayed puberty; their growth hormone responses increased after "priming" with testosterone, reaching values &gt; 10 micrograms/l in two of them and allowing diagnosis of "true" growth hormone deficiency in the third.	Arginine	131-139	growth hormone 1	Homo sapiens	28-42
9480094-4	1994	Further molecular genetic studies showed that the Sr polymorphism is associated with a C to T substitution at base 2004 in the GP IIIa gene resulting in an Arg/Cys amino acid dimorphism at position 636.	Arginine	156-159	integrin subunit beta 3	Homo sapiens	127-134
8190118-8	1994	In the C-domain of calreticulin, which contains the low affinity/high capacity Ca2+ binding sites, acidic residues are interspersed at regular intervals with one or more positively charged lysine and arginine residues.	Arginine	200-208	calreticulin	Homo sapiens	19-31
7819327-5	1994	Our results show that both endoproteases generate mature SRIF-28 from prosomatostatin-II but that only Yap3 can process the homologous monobasic cleavage site (ie single arginine residue) found in prosomatostatin-I.	Arginine	170-178	Yap3p	Saccharomyces cerevisiae S288C	103-107
8187245-3	1994	The latter is a highly electropositive surface near the C-terminal helix of thrombin abundant in arginine and lysine residues.	Arginine	97-105	coagulation factor II, thrombin	Homo sapiens	76-84
7889199-2	1994	A rat model of carotid artery injury was used i) to investigate the effect of single topical application of angiotensin II subtype 1 (AT1) receptor antagonists (CV11974, DuP753) in suppressing medial proliferation at day 2 and neointimal proliferation at day 14, and ii) to investigate the antiproliferative effects of additional application of L-arginine (a nitric oxide precursor).	Arginine	345-355	angiotensinogen	Rattus norvegicus	108-122
8012902-5	1994	Paradoxically, L-arginine (10 microM) had an inhibiting rather than an enhancing effect on the bradykinin relaxation.	Arginine	15-25	kininogen 1	Homo sapiens	95-105
8304499-5	1994	In addition, a 30-min exposure to extracellular L-arginine (100 microM) moderately but significantly decreased the sensitivity to ACh and SIN-1 of vessels from LPS-treated but not from control rats.	Arginine	48-58	MAPK associated protein 1	Homo sapiens	138-143
8003637-4	1994	Arginine supplementation in 29 patients with diabetes mellitus prompted a 2-fold increase of IL-1 alpha from baseline levels (P &lt; 0.001) while IL-1 beta was unaffected.	Arginine	0-8	interleukin 1 beta	Homo sapiens	146-155
7704558-0	1994	Frequent constitutional C to T mutations in CGA-arginine codons in the RB1 gene produce premature stop codons in patients with bilateral (hereditary) retinoblastoma.	Arginine	48-56	chromogranin A	Homo sapiens	44-47
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Arginine	74-77	catalase	Homo sapiens	66-69
7903661-0	1994	Nonsense mutations at Arg-1947 in two cases of familial neurofibromatosis type 1 in Japanese.	Arginine	22-25	neurofibromin 1	Homo sapiens	56-80
7833952-1	1994	To date, the only known apolipoprotein B (apo B) mutation causing hypercholesterolemia is the apo B 3500 Arg--&gt;Gln or the familial defective apo B (FDB) mutation.	Arginine	105-108	apolipoprotein B	Homo sapiens	24-40
7833952-1	1994	To date, the only known apolipoprotein B (apo B) mutation causing hypercholesterolemia is the apo B 3500 Arg--&gt;Gln or the familial defective apo B (FDB) mutation.	Arginine	105-108	apolipoprotein B	Homo sapiens	42-47
7833952-1	1994	To date, the only known apolipoprotein B (apo B) mutation causing hypercholesterolemia is the apo B 3500 Arg--&gt;Gln or the familial defective apo B (FDB) mutation.	Arginine	105-108	apolipoprotein B	Homo sapiens	94-99
7903661-1	1994	We report two familial cases of NF1 presenting as C to T transitions changing an Arg-1947 codon to a stop codon.	Arginine	81-84	neurofibromin 1	Homo sapiens	32-35
7833952-1	1994	To date, the only known apolipoprotein B (apo B) mutation causing hypercholesterolemia is the apo B 3500 Arg--&gt;Gln or the familial defective apo B (FDB) mutation.	Arginine	105-108	apolipoprotein B	Homo sapiens	94-99
8119733-10	1994	Substitution of his &gt; arg at position 114 blocked surface expression of both 242K and wild-type HLA-A*0201 molecules.	Arginine	25-28	major histocompatibility complex, class I, A	Homo sapiens	99-104
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Arginine	30-33	fibronectin 1	Homo sapiens	89-100
8130654-2	1994	The trypsin-generated active form can not only cleave a small synthetic substrate, hippuryl-L-arginine, but can remove terminal arginine from bradykinin.	Arginine	94-102	kininogen 1	Homo sapiens	142-152
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Arginine	30-33	fibronectin 1	Homo sapiens	283-294
7881019-7	1994	These observations suggest that the acute inhibition of acid responses to pentagastrin by endotoxin and IL-1 beta involves nitric oxide (NO) synthesis from L-arginine.	Arginine	156-166	interleukin 1 beta	Rattus norvegicus	104-113
8133311-4	1994	NO is formed from L-arginine by the enzyme NO synthase (NOS), for which tetrahydrobiopterin (BH4) is a necessary co-factor.	Arginine	18-28	nitric oxide synthase 2	Homo sapiens	43-54
7967473-1	1994	We report here a novel mutation in the codon for amino acid 263 resulting in the change from arginine to glutamine in the pyruvate dehydrogenase (PDH) E1 alpha gene, in two boys with primary lactic acidaemia, from independent families.	Arginine	93-101	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	122-144
7967473-1	1994	We report here a novel mutation in the codon for amino acid 263 resulting in the change from arginine to glutamine in the pyruvate dehydrogenase (PDH) E1 alpha gene, in two boys with primary lactic acidaemia, from independent families.	Arginine	93-101	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	146-149
8145742-2	1994	By site-directed mutagenesis the Arg-31 residue of mature TNF was substituted by Gln.	Arginine	33-36	tumor necrosis factor	Homo sapiens	58-61
18472928-0	1994	A novel Mutein of TNFalpha Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine.	Arginine	42-45	tumor necrosis factor	Homo sapiens	18-26
18472928-6	1994	These results suggest that the Arg-Gly-Asp sequence introduced into the TNFalpha molecule abrogates the side effect of this cytokine such as tissue injury or shock, and that F4168 could be useful for systemic therapy.	Arginine	31-34	tumor necrosis factor	Homo sapiens	72-80
7903302-11	1993	The Arg-Lys sequence at positions 25-31, which resembles the binding site of apolipoprotein E, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor with high efficiency.	Arginine	4-7	apolipoprotein E	Rattus norvegicus	77-93
8528889-5	1994	Nitric oxide synthase (NOS), the enzyme in nitric oxidergic neurons that converts arginine into citrulline plus NO, is inactive in the phosphorylated state.	Arginine	82-90	nitric oxide synthase 2	Homo sapiens	0-21
8253769-5	1993	The carboxyl terminus of the secreted recombinant ACE, AGQR, was established by carboxyl-terminal microsequencing and corresponds to a cleavage site between Arg-1137 and Leu-1138.	Arginine	157-160	angiotensin I converting enzyme	Homo sapiens	50-53
8262952-1	1993	Fibronectin binds to platelet membrane glycoprotein (GP) IIb-IIIa in Arg-Gly-Asp (RGD)-dependent and -independent manner.	Arginine	69-72	fibronectin 1	Homo sapiens	0-11
7903170-7	1993	Indeed, A alpha Glu-11 of fibrinogen has recently been proposed to stabilize the local conformation, including the beta-turn, and to form a salt bridge between its side-chain carboxyl group and the guanidino group of Arg-173 of thrombin based on crystallographic analyses using analogs of fibrinopeptide A complexed with thrombin (Stubb et al, Eur J Biochem 206:187, 1992 and Martin et al, J Biol Chem 267:7911, 1992).	Arginine	217-220	fibrinogen beta chain	Homo sapiens	26-36
7903170-7	1993	Indeed, A alpha Glu-11 of fibrinogen has recently been proposed to stabilize the local conformation, including the beta-turn, and to form a salt bridge between its side-chain carboxyl group and the guanidino group of Arg-173 of thrombin based on crystallographic analyses using analogs of fibrinopeptide A complexed with thrombin (Stubb et al, Eur J Biochem 206:187, 1992 and Martin et al, J Biol Chem 267:7911, 1992).	Arginine	217-220	coagulation factor II, thrombin	Homo sapiens	228-236
7903170-7	1993	Indeed, A alpha Glu-11 of fibrinogen has recently been proposed to stabilize the local conformation, including the beta-turn, and to form a salt bridge between its side-chain carboxyl group and the guanidino group of Arg-173 of thrombin based on crystallographic analyses using analogs of fibrinopeptide A complexed with thrombin (Stubb et al, Eur J Biochem 206:187, 1992 and Martin et al, J Biol Chem 267:7911, 1992).	Arginine	217-220	coagulation factor II, thrombin	Homo sapiens	321-329
8290340-6	1993	However, mutation of the arginine but not lysine, in both the KCR and the KSR series abolished DNA-binding activity.	Arginine	25-33	kinase suppressor of ras 1	Homo sapiens	74-77
8253759-7	1993	In contrast, combining the Asp143--&gt;Asn and Ala145--&gt;Arg mutations (D143N-A145R) resulted in a complete loss of binding to the 55-kDa TNF receptor, whereas binding to the 75-kDa TNF receptor was impaired by only 5-10-fold.	Arginine	59-62	tumor necrosis factor	Homo sapiens	140-143
8253759-7	1993	In contrast, combining the Asp143--&gt;Asn and Ala145--&gt;Arg mutations (D143N-A145R) resulted in a complete loss of binding to the 55-kDa TNF receptor, whereas binding to the 75-kDa TNF receptor was impaired by only 5-10-fold.	Arginine	59-62	tumor necrosis factor	Homo sapiens	184-187
7508326-2	1993	Effects of dexamethasone on induction of nitric oxide (NO) synthase and L-arginine transport by lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line J774.	Arginine	72-82	toll-like receptor 4	Mus musculus	116-119
8053762-9	1993	The growth hormone peak in response to arginine-insulin were low in these 4 patients (1.5 ng/ml; 3.8 ng/ml; 5 ng/ml; 4.8 ng/ml).	Arginine	39-47	growth hormone 1	Homo sapiens	4-18
8172556-18	1993	In order to control the autoactivation process point mutant cDNAs were constructed through altering the Arg-Ile bond in the catalytic domain of the C1r.	Arginine	104-107	complement C1r	Homo sapiens	148-151
7508326-5	1993	Despite a high intracellular concentration of arginine in activated J774 cells, LPS (1 microgram ml-1, 8 h) induced a 2.4 fold increase in arginine transport.	Arginine	139-147	toll-like receptor 4	Mus musculus	80-83
7508326-6	1993	Treatment of cells with cycloheximide (1 microgram ml-1) inhibited the time-dependent (1-8 h) induction of NO synthase and arginine transport mediated by LPS.	Arginine	123-131	toll-like receptor 4	Mus musculus	154-157
7508326-8	1993	Induction of NO synthase by LPS (1 microgram ml-1, 24 h) alone was accompanied by a marked increase in arginine utilisation leading to decreased intracellular arginine levels and elevated intracellular and extracellular L-citrulline levels.	Arginine	103-111	toll-like receptor 4	Mus musculus	28-31
7508326-8	1993	Induction of NO synthase by LPS (1 microgram ml-1, 24 h) alone was accompanied by a marked increase in arginine utilisation leading to decreased intracellular arginine levels and elevated intracellular and extracellular L-citrulline levels.	Arginine	159-167	toll-like receptor 4	Mus musculus	28-31
7508326-14	1993	We conclude that induction of arginine transporter activity in LPS-stimulated J774 cells involves de novo synthesis of carrier proteins, which increases transport of exogenous arginine during enhanced NO production.	Arginine	30-38	toll-like receptor 4	Mus musculus	63-66
8136018-9	1993	gamma T-Thrombin and thrombin Quick I (Arg 67--&gt;Cys) are both altered in anion-binding exosite-I, yet bind to heparin-Sepharose and can be inhibited by AT, HC, and PCI in an essentially normal manner in the absence of heparin.	Arginine	39-42	coagulation factor II, thrombin	Homo sapiens	8-16
8032070-1	1993	Insulin-dependent diabetes mellitus (IDDM) is strongly associated with the presence of arginine in position 52 of the DQ alpha chain and absence of aspartic acid in position 57 of the DQ beta chain in Caucasians.	Arginine	87-95	insulin	Homo sapiens	0-7
8269950-12	1993	Heat-denaturation kinetics for the arginine mutant and wild-type erythropoietin are virtually identical, further indicating the structural similarity between these two molecules.	Arginine	35-43	erythropoietin	Homo sapiens	65-79
8245119-2	1993	NSR1 has three regions: an acidic/serine-rich NH2 terminus, two RNA recognition motifs, and a glycine/arginine-rich COOH terminus.	Arginine	102-110	scavenger receptor class F member 2	Homo sapiens	0-4
8124056-3	1993	Neutrophils were obtained at various time points before, during, and after infusion of L-arginine (17 mg kg-1 min-1 for 30 min) and analyzed for superoxide dismutase inhibitable reduction of ferricytochrome c. The spontaneously occurring respiratory burst of polymorphonuclear leukocytes at basal conditions was compared with that after triggering by 1 mumol/l formylpeptide or 50 ng/ml phorbolester.	Arginine	87-97	CD59 molecule (CD59 blood group)	Homo sapiens	110-115
8136028-8	1993	Sequence comparison with mannan binding protein, another collagen-like molecule which binds the C1s-C1r-C1r-C1s tetramer, suggests Arg A38, and HyL B32, B65, and C29 of C1q as possible interaction sites.	Arginine	131-134	complement C1r	Homo sapiens	100-103
8136028-8	1993	Sequence comparison with mannan binding protein, another collagen-like molecule which binds the C1s-C1r-C1r-C1s tetramer, suggests Arg A38, and HyL B32, B65, and C29 of C1q as possible interaction sites.	Arginine	131-134	complement C1r	Homo sapiens	104-107
8136018-9	1993	gamma T-Thrombin and thrombin Quick I (Arg 67--&gt;Cys) are both altered in anion-binding exosite-I, yet bind to heparin-Sepharose and can be inhibited by AT, HC, and PCI in an essentially normal manner in the absence of heparin.	Arginine	39-42	coagulation factor II, thrombin	Homo sapiens	21-29
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Arginine	186-189	fibroblast growth factor 2	Homo sapiens	152-156
8148872-7	1993	Of the other five, one changes the opal termination codon in Ahrb-1 to the codon for Arg in Ahrd, extending translation of the mRNA by 43 amino acids and accounting for the larger size of the AhR peptide in DBA/2 mice.	Arginine	85-88	aryl-hydrocarbon receptor	Mus musculus	192-195
8129837-0	1993	Studies on long-acting insulin: crystal structure of Arg-B31 human insulin at 2.0A resolution.	Arginine	53-56	insulin	Homo sapiens	23-30
8129837-0	1993	Studies on long-acting insulin: crystal structure of Arg-B31 human insulin at 2.0A resolution.	Arginine	53-56	insulin	Homo sapiens	67-74
8129837-1	1993	The crystal structure of Arg-B31 human insulin (ABHI), a long-acting insulin derivative, has been determined at 2.0 A resolution by using X-ray diffraction analysis.	Arginine	25-28	insulin	Homo sapiens	39-46
8129837-1	1993	The crystal structure of Arg-B31 human insulin (ABHI), a long-acting insulin derivative, has been determined at 2.0 A resolution by using X-ray diffraction analysis.	Arginine	25-28	insulin	Homo sapiens	69-76
7504472-2	1993	This enzyme regulates the de novo synthesis pathway for tetrahydrobiopterin, an essential cofactor for the catalytic conversion of L-arginine to L-citrulline and NO by inducible NO synthase.	Arginine	131-141	nitric oxide synthase 2	Rattus norvegicus	168-189
7504481-1	1993	Conversion of L-arginine to L-citrulline and nitric oxide (NO) by NO synthase induced in the murine EMT-6 cells resulted in the release of a large amount of the stable reactional intermediate N omega-hydroxy-L-arginine into the extracellular medium.	Arginine	14-24	IL2 inducible T cell kinase	Mus musculus	100-103
7504525-7	1993	Peptide mapping provided additional proof that p17 is a fragment which comprises the entire FK506 binding domain I of chicken hsp56, terminating with an Arg-Lys which might represent a processing site.	Arginine	153-156	FKBP prolyl isomerase 4	Homo sapiens	126-131
7902568-8	1993	The mutation at position 723, which changes the amino acid sequence from Arg to Cys at residue 220, showed complete association with the PGM1 2/1 protein polymorphism: DNA from individuals showing the PGM1 1 isozyme carried the Arg codon CGT, whereas individuals showing the PGM1 2 isozyme carried the Cys codon TGT.	Arginine	73-76	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	312-315
8244341-5	1993	The mutation, which resides in the triple-helical region of type II procollagen at amino acid position 75, is the second example of an Arg-->Cys mutation in the COL2A1 gene in heritable cartilaginous disease and is the first example of a point mutation in the amino terminal region of the alpha 1(II) chain, that results in a spondyloepiphyseal dysplastic phenotype.	Arginine	135-138	collagen type II alpha 1 chain	Homo sapiens	161-167
8218262-4	1993	Recently, we reported that N-myristoylation of the synthetic peptide substrate Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu (RKRTLRRL) transformed a peptide that completely lacked inhibitory activity against the histone kinase reactions of PKC and its catalytic fragment into a peptide that potently inhibited both of these reactions.	Arginine	79-82	proline rich transmembrane protein 2	Homo sapiens	227-230
8218262-4	1993	Recently, we reported that N-myristoylation of the synthetic peptide substrate Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu (RKRTLRRL) transformed a peptide that completely lacked inhibitory activity against the histone kinase reactions of PKC and its catalytic fragment into a peptide that potently inhibited both of these reactions.	Arginine	87-90	proline rich transmembrane protein 2	Homo sapiens	227-230
8218262-4	1993	Recently, we reported that N-myristoylation of the synthetic peptide substrate Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu (RKRTLRRL) transformed a peptide that completely lacked inhibitory activity against the histone kinase reactions of PKC and its catalytic fragment into a peptide that potently inhibited both of these reactions.	Arginine	87-90	proline rich transmembrane protein 2	Homo sapiens	227-230
7694154-2	1993	Mutations at Lys 335 and Arg 347 in the sixth predicted transmembrane helix of CFTR alter its halide selectivity in whole-cell studies and its single channel conductance, but the physical basis of these alterations is unknown and permeation in CFTR is poorly understood.	Arginine	25-28	CF transmembrane conductance regulator	Homo sapiens	79-83
7694154-2	1993	Mutations at Lys 335 and Arg 347 in the sixth predicted transmembrane helix of CFTR alter its halide selectivity in whole-cell studies and its single channel conductance, but the physical basis of these alterations is unknown and permeation in CFTR is poorly understood.	Arginine	25-28	CF transmembrane conductance regulator	Homo sapiens	244-248
8136894-0	1993	Growth hormone secretion in Alzheimer"s disease: studies with growth hormone-releasing hormone alone and combined with pyridostigmine or arginine.	Arginine	137-145	growth hormone 1	Homo sapiens	0-14
8240272-5	1993	In the pancreas, there were unmodified, mono- and di-phosphorylated forms of the fragment chromogranin A(248-313) with Arg and Glu at positions 293 and 301 respectively; in addition, there were small amounts of monophosphorylated peptide with an alternative primary sequence of His and Lys at 293 and 301 respectively.	Arginine	119-122	chromogranin A	Bos taurus	90-104
8136274-6	1993	The lesion responsible was determined by PCR/direct sequencing to be a heterozygous CGT/TGT transition in exon 3 of the protein C gene resulting in the substitution of Arg by Cys at residue--1 in the pro-peptide leader sequence.	Arginine	168-171	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	88-91
8221663-2	1993	Mutations of the p53 gene were found in six of seven ES cell lines: a missense mutation of TGC (Cys)--&gt;TAC (Try) at codon 141 in one, a missense mutation of CGT (Arg)--&gt;TGT (Cys) at codon 273 in one, a missense mutation of TGC (Cys)--&gt;TTC (Phe) at codon 176 in three, and one base deletion of CGC--&gt;CG at codon 283 in one.	Arginine	165-168	tumor protein p53	Homo sapiens	17-20
8281139-5	1993	To our knowledge, only one germline Arg to Gln androgen receptor gene mutation has been previously reported at position 607 in male breast cancer.	Arginine	36-39	androgen receptor	Homo sapiens	47-64
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Arginine	52-60	fibronectin 1	Homo sapiens	34-45
7694665-4	1993	Swine fed an atherosclerotic diet supplemented with L-arginine developed atherosclerotic plaques that also contained increased levels of acidic fibroblast growth factor mRNA.	Arginine	52-62	fibroblast growth factor 1	Sus scrofa	137-168
21573446-8	1993	The point mutation of p53 gene was found at codon 181 contained C to T transversions (Amino acid switch: Arg --&gt; Cys) in ES-4 esophageal cancer.	Arginine	105-108	tumor protein p53	Homo sapiens	22-25
8227340-4	1993	IGF-I treatment led to reduced fasting and stimulated (glucose and/or L-arginine) insulin and growth hormone secretion.	Arginine	70-80	insulin like growth factor 1	Homo sapiens	0-5
8227340-4	1993	IGF-I treatment led to reduced fasting and stimulated (glucose and/or L-arginine) insulin and growth hormone secretion.	Arginine	70-80	insulin	Homo sapiens	82-89
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Arginine	52-60	fibronectin 1	Homo sapiens	212-223
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Arginine	95-98	fibronectin 1	Homo sapiens	34-45
7509429-5	1993	The active amino acid sequence in fibronectin is an arginine-glycine-aspartic acid tripeptide (Arg-Gly-Asp) and it was shown that the synthetic Arg-Gly-Asp peptide specifically inhibited the adhesive function of fibronectin in trabecular meshwork samples when incubated for 30 min at a concentration of 1-2 mg/ml.	Arginine	95-98	fibronectin 1	Homo sapiens	212-223
8284093-3	1993	C5a/C5a(des Arg) levels were determined by a sensitive ELISA based on a neoepitope-specific MAb.	Arginine	12-15	complement C5a receptor 1	Homo sapiens	0-3
8215738-1	1993	BACKGROUND: Familial defective apolipoprotein B-100 is caused by a substitution of adenine for guanine in exon 26 of the gene coding for apolipoprotein B, which results in the substitution of glutamine for arginine in the putative low-density lipoprotein-receptor binding domain of the mature protein.	Arginine	206-214	apolipoprotein B	Homo sapiens	31-47
8215738-1	1993	BACKGROUND: Familial defective apolipoprotein B-100 is caused by a substitution of adenine for guanine in exon 26 of the gene coding for apolipoprotein B, which results in the substitution of glutamine for arginine in the putative low-density lipoprotein-receptor binding domain of the mature protein.	Arginine	206-214	apolipoprotein B	Homo sapiens	137-153
8284093-3	1993	C5a/C5a(des Arg) levels were determined by a sensitive ELISA based on a neoepitope-specific MAb.	Arginine	12-15	complement C5a receptor 1	Homo sapiens	4-7
8241653-0	1993	Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children.	Arginine	23-31	growth hormone 1	Homo sapiens	45-59
8405430-4	1993	The flip form of GluR2 and GluR3 dominate and the GluR2 mRNA is present in the arginine encoding form.	Arginine	79-87	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	50-55
8413273-7	1993	We show that mutations, either conservative or not, in any one of the three arginines in the HRIGRXXR sequence drastically reduced eIF-4A cross-linking to RNA.	Arginine	76-85	eukaryotic translation initiation factor 4A1	Homo sapiens	131-137
8241653-0	1993	Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children.	Arginine	23-31	growth hormone releasing hormone	Homo sapiens	72-104
7764097-2	1993	In addition to signal peptide processing these modifications are: (1) removal of C-terminal Arg-Ser by Kex1p, (2) glutathionylation of Cys95, (3) O-glycosylation, and (4) additional degradation of the C-terminus.	Arginine	92-95	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	103-108
7764275-1	1993	The blocked-N-terminal structure of hog kidney aldose 1-epimerase (mutarotase, EC 5.1.3.3) was determined to be Ac-Val-Ser-Val-Thr-Arg-Ser-Val-Phe-Gly-Asp... by a coupling of conventional methods (enzymatic digestion, amino acid analysis, and Edman sequencing) and tandem mass spectrometry.	Arginine	131-134	galactose mutarotase	Homo sapiens	47-65
8269791-7	1993	Genetic analysis revealed a point mutation affecting residue 65 of human proinsulin (Arg--&gt;His) in one allele of the insulin gene in the propositus, a defect similar to that described previously in 3 other apparently unrelated lineages.	Arginine	85-88	insulin	Homo sapiens	73-83
8125051-2	1993	On isoelectric focusing in an immobilized pH gradient, apoE5-Frankfurt migrated to a position more cathodic than apoE4 (Cys112-&gt;Arg).	Arginine	131-134	apolipoprotein E	Homo sapiens	113-118
8269791-7	1993	Genetic analysis revealed a point mutation affecting residue 65 of human proinsulin (Arg--&gt;His) in one allele of the insulin gene in the propositus, a defect similar to that described previously in 3 other apparently unrelated lineages.	Arginine	85-88	insulin	Homo sapiens	76-83
8225311-0	1993	Deletion of arginine (608) in acid sphingomyelinase is the prevalent mutation among Niemann-Pick disease type B patients from northern Africa.	Arginine	12-20	sphingomyelin phosphodiesterase 1	Homo sapiens	30-51
8225311-8	1993	Our results indicate that deletion of arginine 608 in the acid sphingomyelinase gene is the highly prevalent mutation underlying Niemann-Pick type B disease in the population of Maghreb.	Arginine	38-46	sphingomyelin phosphodiesterase 1	Homo sapiens	58-79
7690755-5	1993	RC*D(ThioP)C* inhibits alpha 5 beta 1-mediated leukocyte adhesion to the 120-kDa Arg-Gly-Asp (RGD)-containing binding site of fibronectin.	Arginine	81-84	fibronectin 1	Homo sapiens	126-137
8251938-9	1993	In the bifunctional inhibitor-thrombin complex, the peptide bond between Arg-Pro (P1-P1") seems to be cleaved.	Arginine	73-76	coagulation factor II, thrombin	Homo sapiens	30-38
8102510-0	1993	A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential in short-chain acyl-CoA dehydrogenase (SCAD).	Arginine	110-118	acyl-CoA dehydrogenase medium chain	Homo sapiens	42-77
8373786-2	1993	Intact fibronectin molecule and its 120 kDa fragment, containing the Arg-Gly-Asp (RGD) sequence motif, as well as a synthetic RGD-containing peptide Peptite 2000 all bound progenitor cells.	Arginine	69-72	fibronectin 1	Homo sapiens	7-18
8373786-4	1993	The binding of intact fibronectin and its 120 kDa fragment was inhibited in a dose-dependent fashion with increasing concentration of RGD-containing Gly-Arg-Gly-Asp-Ser peptide, but not with Gly-Arg-Gly-Glu-Ser control peptide that does not contain the RGD sequence motif.	Arginine	153-156	fibronectin 1	Homo sapiens	22-33
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Arginine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	67-85
8103045-2	1993	We have previously demonstrated that a basic amino acid residue of interleukin (IL)-8, namely Arg-6, is critical for the binding of IL-8 to its receptor.	Arginine	94-97	C-X-C motif chemokine ligand 8	Homo sapiens	132-136
8102510-0	1993	A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential in short-chain acyl-CoA dehydrogenase (SCAD).	Arginine	110-118	acyl-CoA dehydrogenase medium chain	Homo sapiens	79-83
8102510-0	1993	A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential in short-chain acyl-CoA dehydrogenase (SCAD).	Arginine	110-118	acyl-CoA dehydrogenase short chain	Homo sapiens	169-203
8102510-0	1993	A rare disease-associated mutation in the medium-chain acyl-CoA dehydrogenase (MCAD) gene changes a conserved arginine, previously shown to be functionally essential in short-chain acyl-CoA dehydrogenase (SCAD).	Arginine	110-118	acyl-CoA dehydrogenase short chain	Homo sapiens	205-209
8214107-3	1993	The production of biologically active NO was demonstrated by L-arginine-dependent guanosine 3",5"-cyclic monophosphate (cGMP) accumulation after a 3-h exposure to either IL-1 beta or lipopolysaccharide (LPS).	Arginine	61-71	interleukin 1 beta	Rattus norvegicus	170-179
8102510-6	1993	The mutation changes conserved arginine at position 28 (R28C) of the mature MCAD protein.	Arginine	31-39	acyl-CoA dehydrogenase medium chain	Homo sapiens	76-80
8102510-12	1993	It is, however, noteworthy that a homologous mutation has previously been identified in the short-chain acyl-CoA dehydrogenase (SCAD) gene of a patient with SCAD deficiency, suggesting that the conserved arginine is crucial for formation of active enzyme in the straight-chain acyl-CoA dehydrogenases.	Arginine	204-212	acyl-CoA dehydrogenase short chain	Homo sapiens	92-126
8102510-12	1993	It is, however, noteworthy that a homologous mutation has previously been identified in the short-chain acyl-CoA dehydrogenase (SCAD) gene of a patient with SCAD deficiency, suggesting that the conserved arginine is crucial for formation of active enzyme in the straight-chain acyl-CoA dehydrogenases.	Arginine	204-212	acyl-CoA dehydrogenase short chain	Homo sapiens	128-132
8239537-5	1993	A CGA to TGA nonsense mutation at codon 390 with arginine being substituted with a stop codon was detected and predicted to encode a faulty WT1 protein in this WT, out of 8 WTs studied.	Arginine	49-57	chromogranin A	Homo sapiens	2-5
8239537-5	1993	A CGA to TGA nonsense mutation at codon 390 with arginine being substituted with a stop codon was detected and predicted to encode a faulty WT1 protein in this WT, out of 8 WTs studied.	Arginine	49-57	WT1 transcription factor	Homo sapiens	140-143
7693277-0	1993	Prevention by an inhibitor of the L-arginine-nitric oxide pathway of the antiarrhythmic effects of bradykinin in anaesthetized dogs.	Arginine	34-44	kininogen 1	Canis lupus familiaris	99-109
7689960-3	1993	The effects were studied of the NO donors, L-arginine, syndnonimine-1 (SIN-1) and sodium nitroprusside, on both the basal and stimulated release of AVP, employing a previously validated system.	Arginine	43-53	arginine vasopressin	Rattus norvegicus	148-151
8220876-9	1993	Since it has been found that pretreatment with L-arginine can reveal a vasodilator effect of AII (3-8) on rabbit pial arterioles, we assessed responses to AII (3-8) (12.5 nmol kg-1) before and 5 min after onset of a primed infusion of L-arginine (1.4 mmol kg-1 bolus, 1.4 mmol kg-1 h-1 infusion).	Arginine	47-57	angiotensinogen	Rattus norvegicus	93-96
8220876-9	1993	Since it has been found that pretreatment with L-arginine can reveal a vasodilator effect of AII (3-8) on rabbit pial arterioles, we assessed responses to AII (3-8) (12.5 nmol kg-1) before and 5 min after onset of a primed infusion of L-arginine (1.4 mmol kg-1 bolus, 1.4 mmol kg-1 h-1 infusion).	Arginine	235-245	angiotensinogen	Rattus norvegicus	93-96
7504627-1	1993	Nitric oxide (NO) produced from L-arginine by NO synthases (NOS) is a transmitter known to be involved in diverse biological processes, including immunomodulation, neurotransmission and blood vessel dilatation.	Arginine	32-42	nitric oxide synthase 2	Homo sapiens	46-58
7692046-1	1993	Arginine is oxidized by a class of enzymes called the nitric oxide synthases (NOS) to generate citrulline and, presumably, nitric oxide (.NO).	Arginine	0-8	nitric oxide synthase 2	Homo sapiens	54-76
7689960-6	1993	L-arginine reduced KCl-evoked AVP release; this effect was reversed by L-NMMA and reduced by the addition of ferrous human Hb.	Arginine	0-10	arginine vasopressin	Homo sapiens	30-33
7689960-8	1993	L-arginine also reduced IL-1 beta-stimulated AVP release.	Arginine	0-10	interleukin 1 beta	Rattus norvegicus	24-33
7689960-8	1993	L-arginine also reduced IL-1 beta-stimulated AVP release.	Arginine	0-10	arginine vasopressin	Rattus norvegicus	45-48
8361764-4	1993	A third mutant 175 (Arg--&gt;His) bound to the p53CON but did not activate transcription.	Arginine	20-23	tumor protein p53	Homo sapiens	47-50
8375390-1	1993	A porcine pancreatic phospholipase A2 mutant was constructed in which all nine lysines were replaced by arginines.	Arginine	104-113	phospholipase A2 group IB	Homo sapiens	21-37
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	Arginine	138-148	interleukin 1 beta	Mus musculus	0-9
8376600-8	1993	L-arginine did not alter the magnitude of AVP-induced vasoconstriction at the lower doses, but L-arginine augmented the magnitude of AVP-induced vasodilation at doses of 0.2 (P &lt; 0.05), 0.5 (P &lt; 0.01), and 1.0 (P &lt; 0.05) ng/kg per min.	Arginine	95-105	arginine vasopressin	Homo sapiens	133-136
8376602-1	1993	Transgenic mice were prepared that expressed a dysfunctional apo E variant, apo E (Arg-112, Cys-142), which is associated with dominant inheritance of type III hyperlipoproteinemia (type III HLP) in humans.	Arginine	83-86	apolipoprotein E	Homo sapiens	61-66
8376602-1	1993	Transgenic mice were prepared that expressed a dysfunctional apo E variant, apo E (Arg-112, Cys-142), which is associated with dominant inheritance of type III hyperlipoproteinemia (type III HLP) in humans.	Arginine	83-86	apolipoprotein E	Homo sapiens	76-81
8376602-2	1993	Among eight founder mice, plasma apo E (Arg-112, Cys-142) levels varied 100-fold and directly correlated with plasma cholesterol and triglyceride levels.	Arginine	40-43	apolipoprotein E	Mus musculus	33-38
8376602-8	1993	Thus, transgenic mice expressing high levels of the dysfunctional apo E (Arg-112, Cys-142) variant have many characteristics of the human type III HLP phenotype and appear to be a suitable animal model for this disorder.	Arginine	73-76	apolipoprotein E	Mus musculus	66-71
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	48-56	growth hormone 1	Homo sapiens	115-117
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	48-56	growth hormone releasing hormone	Homo sapiens	139-143
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	48-56	growth hormone 1	Homo sapiens	139-141
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	48-56	growth hormone releasing hormone	Homo sapiens	223-227
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	48-56	growth hormone releasing hormone	Homo sapiens	223-227
8103770-5	1993	In the second group of 12 hypothyroid patients, arginine infusion (30 g, iv, from 0-30 min) markedly increased the GH responses induced by GHRH administration (1 microgram/kg, iv, at 0 min; peak GH levels for arginine plus GHRH vs. placebo plus GHRH, 30.6 +/- 4.7 vs. 5.3 +/- 1.0 micrograms/L; P &lt; 0.001).	Arginine	209-217	growth hormone 1	Homo sapiens	139-141
8103770-6	1993	However, GH release after GHRH plus arginine was greater in 10 normal subjects than in the hypothyroid patients (peak GH levels, 50.9 +/- 5.3 micrograms/L; P &lt; 0.001).	Arginine	36-44	growth hormone 1	Homo sapiens	9-11
8395000-4	1993	Substitution of an arginine that is conserved in these proteins into MyoD (MyoD-R) changes its binding specificity so that it recognizes CACGTG instead of the MyoD cognate sequence (CAGCTG).	Arginine	19-27	myogenic differentiation 1	Homo sapiens	69-73
8395000-4	1993	Substitution of an arginine that is conserved in these proteins into MyoD (MyoD-R) changes its binding specificity so that it recognizes CACGTG instead of the MyoD cognate sequence (CAGCTG).	Arginine	19-27	myogenic differentiation 1	Homo sapiens	75-81
8395000-4	1993	Substitution of an arginine that is conserved in these proteins into MyoD (MyoD-R) changes its binding specificity so that it recognizes CACGTG instead of the MyoD cognate sequence (CAGCTG).	Arginine	19-27	myogenic differentiation 1	Homo sapiens	75-79
8367461-4	1993	Interactions due to the "Pro-Arg motif" (Arg occupancy of the S1 specificity pocket; formation of a hydrogen-bonded two-strand antiparallel beta-sheet with Ser214-Gly216) and the alpha-keto amide group of CtA are primarily responsible for binding to thrombin, with the alpha-keto amide serving as a transition-state analogue.	Arginine	29-32	coagulation factor II, thrombin	Homo sapiens	250-258
8367462-3	1993	The Arg-specific pocket of HLA-B*2705 differs markedly from those of HLA-A*0201 and HLA-A*6801, as a result of numerous differences in the side chains that form the pocket"s surface.	Arginine	4-7	major histocompatibility complex, class I, A	Homo sapiens	69-74
8367462-3	1993	The Arg-specific pocket of HLA-B*2705 differs markedly from those of HLA-A*0201 and HLA-A*6801, as a result of numerous differences in the side chains that form the pocket"s surface.	Arginine	4-7	major histocompatibility complex, class I, A	Homo sapiens	84-89
7689333-1	1993	L-NG-Nitroarginine (NA) inhibited both the L-arginine oxidation and the L-arginine-independent NADPH oxidation reactions catalyzed by the calcium/calmodulin-dependent constitutive nitric oxide synthase (cNOS) from bovine brain.	Arginine	72-82	nitric oxide synthase 3	Bos taurus	203-207
8259537-6	1993	Thus, the hypothetical two-pronged socket-like structure consisting of the alpha-amino group of the amino-terminal Gly and the guanidino group of an Arg at position 3 of the normal fibrin alpha-chain seems to be restored considerably in the mutant fibrin alpha-chain at low ionic strengths and pH"s, despite the replacement of the amino-terminal Gly by another aliphatic amino acid Val.	Arginine	149-152	Fc gamma receptor and transporter	Homo sapiens	188-199
8259537-6	1993	Thus, the hypothetical two-pronged socket-like structure consisting of the alpha-amino group of the amino-terminal Gly and the guanidino group of an Arg at position 3 of the normal fibrin alpha-chain seems to be restored considerably in the mutant fibrin alpha-chain at low ionic strengths and pH"s, despite the replacement of the amino-terminal Gly by another aliphatic amino acid Val.	Arginine	149-152	Fc gamma receptor and transporter	Homo sapiens	255-266
8143212-7	1993	The data showed that the 2% of total energy supplied by arginine was found to significantly enhance the T lymphocyte response to PHA, CD4 phenotype expression, CD4/CD8 ratio, IL-2 production and IL-2 receptor expression, as compared with the control group.	Arginine	56-64	CD4 molecule	Homo sapiens	134-137
8143212-7	1993	The data showed that the 2% of total energy supplied by arginine was found to significantly enhance the T lymphocyte response to PHA, CD4 phenotype expression, CD4/CD8 ratio, IL-2 production and IL-2 receptor expression, as compared with the control group.	Arginine	56-64	CD4 molecule	Homo sapiens	160-163
8143212-7	1993	The data showed that the 2% of total energy supplied by arginine was found to significantly enhance the T lymphocyte response to PHA, CD4 phenotype expression, CD4/CD8 ratio, IL-2 production and IL-2 receptor expression, as compared with the control group.	Arginine	56-64	interleukin 2	Homo sapiens	175-179
7689333-7	1993	The Km for L-arginine in the cNOS reaction was 1.2 microM.	Arginine	11-21	nitric oxide synthase 3	Bos taurus	29-33
7689333-8	1993	The NA binding sites of cNOS were titrated with NA, which enabled a kcat of 0.7 s-1, for the oxidation of L-arginine, to be calculated.	Arginine	106-116	nitric oxide synthase 3	Bos taurus	24-28
8344203-6	1993	The native proinsulin structure was B-chain-Arg-Arg-C-peptide-Lys-Arg-A-chain.	Arginine	48-51	insulin	Homo sapiens	11-21
8349606-5	1993	Fluorescence-detected melting curves of Glu-Gly-Arg-cmk-urokinase indicated that unfolding/refolding at pH 4.5 is characterized by dramatic hysteresis; the cooling curves fell close to those obtained upon heating or cooling of the uninhibited enzyme.	Arginine	48-51	C-X-C motif chemokine ligand 9	Homo sapiens	52-55
8401516-0	1993	Acute intermittent porphyria caused by an arginine to histidine substitution (R26H) in the cofactor-binding cleft of porphobilinogen deaminase.	Arginine	42-50	hydroxymethylbilane synthase	Homo sapiens	117-142
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	179-182	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	183-186	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	183-186	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	183-186	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	183-186	insulin	Homo sapiens	20-30
8344203-5	1993	We created a mutant proinsulin DNA with a peptide structure comprised of B- and A-chains linked to the C-peptide by a pair of tetrabasic residues, in the following order: B-chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A-chain.	Arginine	183-186	insulin	Homo sapiens	20-30
8344203-6	1993	The native proinsulin structure was B-chain-Arg-Arg-C-peptide-Lys-Arg-A-chain.	Arginine	44-47	insulin	Homo sapiens	11-21
8344203-6	1993	The native proinsulin structure was B-chain-Arg-Arg-C-peptide-Lys-Arg-A-chain.	Arginine	48-51	insulin	Homo sapiens	11-21
8241567-9	1993	dpy-10(cn64), a dominant temperature-sensitive DLRol allele, creates an Arg-to-Cys substitution in the amino non-Gly-X-Y portion of the protein.	Arginine	72-75	Uncharacterized protein	Caenorhabditis elegans	0-6
8395550-15	1993	Furthermore, the residue corresponding to Arg 46 of the thrombin receptor is critical for receptor agonist activity.	Arginine	42-45	coagulation factor II, thrombin	Homo sapiens	56-64
8342121-12	1993	Serum insulin-like growth factor-1 levels were significantly elevated in the arginine group.	Arginine	77-85	insulin like growth factor 1	Homo sapiens	6-34
7763945-2	1993	The enzyme showed a high affinity toward the Pro-X (X = Gln, Lys, Leu or Arg) bonds of substance P, dynorphin A (1-13), neurotensin and chicken brain pentapeptide, and the R-R bonds in dynorphin A and neurotensin.	Arginine	73-76	neurotensin	Gallus gallus	120-131
7763945-2	1993	The enzyme showed a high affinity toward the Pro-X (X = Gln, Lys, Leu or Arg) bonds of substance P, dynorphin A (1-13), neurotensin and chicken brain pentapeptide, and the R-R bonds in dynorphin A and neurotensin.	Arginine	73-76	neurotensin	Gallus gallus	201-212
8332900-3	1993	Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk.	Arginine	76-84	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	116-119
8332900-3	1993	Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk.	Arginine	76-84	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	16-19
8332900-3	1993	Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk.	Arginine	76-84	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	129-132
7686905-2	1993	Brain NO (nitric oxide) synthase contains FAD, FMN, heme, and tetrahydrobiopterin as prosthetic groups and represents a multi-functional oxidoreductase catalyzing oxidation of L-arginine to NO and L-citrulline, formation of H2O2, and reduction of cytochrome c.	Arginine	176-186	cytochrome c, somatic	Homo sapiens	247-259
8338131-4	1993	Conversely, preincubation of neutrophils with 0.5 mM L-arginine augmented the release of LF and MPO in FMLP- and A-23187-stimulated cells.	Arginine	53-63	myeloperoxidase	Homo sapiens	96-99
8344795-7	1993	CONCLUSION: These findings demonstrate that in porcine ciliary arteries, local anesthetics impair endothelial formation of nitric oxide from L-arginine after stimulation with bradykinin, which may contribute importantly to the reduction in blood flow to the eye during retrobulbar anesthesia.	Arginine	141-151	kininogen 1	Homo sapiens	175-185
8338131-4	1993	Conversely, preincubation of neutrophils with 0.5 mM L-arginine augmented the release of LF and MPO in FMLP- and A-23187-stimulated cells.	Arginine	53-63	formyl peptide receptor 1	Homo sapiens	103-107
8323289-0	1993	Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.	Arginine	19-27	cytochrome p450 oxidoreductase	Homo sapiens	106-137
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Arginine	89-97	cytochrome p450 oxidoreductase	Homo sapiens	154-185
8102338-4	1993	Single amino acid substitutions replacing Arg 201 with either Cys, His, or Gln 227 with either Arg or Leu of the alpha-subunit of the Gs gene were identified in one third of growth hormone (GH)-secreting adenomas.	Arginine	42-45	growth hormone 1	Homo sapiens	174-188
7686861-1	1993	Murine macrophages produce nitric oxide (NO) from L-arginine on stimulation with lipopolysaccharide (LPS), alone or with interferon-gamma (IFN-gamma).	Arginine	50-60	toll-like receptor 4	Mus musculus	101-104
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	124-134	interleukin 1 beta	Rattus norvegicus	218-227
8102338-4	1993	Single amino acid substitutions replacing Arg 201 with either Cys, His, or Gln 227 with either Arg or Leu of the alpha-subunit of the Gs gene were identified in one third of growth hormone (GH)-secreting adenomas.	Arginine	42-45	growth hormone 1	Homo sapiens	190-192
8315224-2	1993	Arginine stimulates GH release, and lysine may amplify this response.	Arginine	0-8	growth hormone 1	Homo sapiens	20-22
24202467-7	1993	The MCH peptide sequence is located at the carboxy terminus of the preprohormone structure and is preceded by a pair of arginine residues which can serve as a proteolytic cleavage site.	Arginine	120-128	pro-melanin concentrating hormone	Homo sapiens	4-7
8227981-1	1993	Aim of this study was to verify whether arginine (ARG), which likely inhibits hypothalamic somatostatin release, has an enhancing effect on the GHRH-induced GH rise, even when administered orally at low dose.	Arginine	40-48	growth hormone releasing hormone	Homo sapiens	144-148
8227981-1	1993	Aim of this study was to verify whether arginine (ARG), which likely inhibits hypothalamic somatostatin release, has an enhancing effect on the GHRH-induced GH rise, even when administered orally at low dose.	Arginine	50-53	growth hormone releasing hormone	Homo sapiens	144-148
8227981-5	1993	Oral ARG-H (Group A, n = 11) induced a significant increase of basal GH levels (4.2 +/- 1.3 vs 1.0 +/- 0.4 micrograms/L, p &lt; 0.02) and enhanced the GH response to GHRH (41.1 +/- 8.6 vs 25.3 +/- 6.7 micrograms/L, p &lt; 0.02).	Arginine	5-8	growth hormone releasing hormone	Homo sapiens	166-170
7686532-5	1993	NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine.	Arginine	14-24	interleukin 1 beta	Rattus norvegicus	48-66
8315224-9	1993	The correlation (p &lt; .005) between measured increments in serum arginine and increases in serum GH after a single dose of arginine/lysine was similar in old and young groups.	Arginine	67-75	growth hormone 1	Homo sapiens	99-101
8315224-9	1993	The correlation (p &lt; .005) between measured increments in serum arginine and increases in serum GH after a single dose of arginine/lysine was similar in old and young groups.	Arginine	125-133	growth hormone 1	Homo sapiens	99-101
8315224-3	1993	We investigated whether oral arginine/lysine could be used to increase basal IGF-I and GH levels in non-obese old men (age 69 +/- 5 years; mean +/- SD) to values similar to those of untreated young men (age 26 +/- 4 years).	Arginine	29-37	insulin like growth factor 1	Homo sapiens	77-82
8315224-3	1993	We investigated whether oral arginine/lysine could be used to increase basal IGF-I and GH levels in non-obese old men (age 69 +/- 5 years; mean +/- SD) to values similar to those of untreated young men (age 26 +/- 4 years).	Arginine	29-37	growth hormone 1	Homo sapiens	87-89
8331161-6	1993	As described for interferon-gamma-treated macrophages, the antiparasitic activity of this microglia population is due to the synthesis of reactive nitrogen intermediates, since it was antagonized by NG-monomethyl-L-arginine, a competitive inhibitor of the arginine-dependent metabolic pathway.	Arginine	215-223	interferon gamma	Mus musculus	17-33
8371062-4	1993	Four subjects were found to have the apoB 3500 codon mutation by mutagenic polymerase chain reaction, which creates an MspI site at the 3500 codon of normal alleles but not alleles coding for the Arg--&gt;Gln mutation of FDB.	Arginine	196-199	apolipoprotein B	Homo sapiens	37-41
8321192-8	1993	Within the NFKB1 portion of this fusion protein, a single amino acid change of His to Arg altered the DNA-binding specificity to favor interaction with the RelA-selective DNA motif.	Arginine	86-89	nuclear factor kappa B subunit 1	Homo sapiens	11-16
8413310-8	1993	These results highlight the importance of Arginine-614 in the second zinc finger of the DNA-binding domain of the AR in the protein-DNA interaction.	Arginine	42-50	androgen receptor	Homo sapiens	114-116
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	71-74	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	22-27
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	71-74	cholecystokinin	Homo sapiens	108-111
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	22-27
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	cholecystokinin	Homo sapiens	108-111
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	22-27
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	cholecystokinin	Homo sapiens	108-111
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	22-27
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	cholecystokinin	Homo sapiens	108-111
7686367-5	1993	178, 884-891] revealed that endothelin 1 (ET-1) increases intracellular free [Ca2+] in polymorphonuclear leucocytes (PMN) by a mechanism that can be inhibited by L-arginine.	Arginine	162-172	endothelin 1	Homo sapiens	28-40
7686367-5	1993	178, 884-891] revealed that endothelin 1 (ET-1) increases intracellular free [Ca2+] in polymorphonuclear leucocytes (PMN) by a mechanism that can be inhibited by L-arginine.	Arginine	162-172	endothelin 1	Homo sapiens	42-46
8499487-5	1993	In addition, the cytotoxic action of TNF was independent of L-arginine substrate availability.	Arginine	60-70	tumor necrosis factor	Homo sapiens	37-40
8344645-4	1993	Before treatment the GH response to GHRH (AUC: 231.9 +/- 106.4 micrograms/l/h) was potentiated (p &lt; 0.001) by ARG (932.6 +/- 166.2 micrograms/l/h).	Arginine	113-116	growth hormone releasing hormone	Homo sapiens	36-40
8376151-10	1993	Complement activation (C4a, C5a [des Arg]) showed a significant increase after initiation of surgery and there was no significant difference between the solco- or patient blood.	Arginine	37-40	complement C5a receptor 1	Homo sapiens	28-31
8501169-2	1993	In an attempt to clarify this variability, we assessed growth parameters, 24-h GH profiles, arginine-stimulated serum GH levels, and plasma insulin-like growth factor-I (IGF-I) concentrations in a group of 41 girls with Turner"s syndrome with a mean (+/- SD) age of 13 +/- 3 yr (range, 6.7-18.9).	Arginine	92-100	growth hormone 1	Homo sapiens	118-120
8321209-4	1993	We isolated a cDNA encoding SRp75 and found that this protein, like other SR proteins, contains an N-terminal RNA recognition motif (RRM), a glycine-rich region, an internal region homologous to the RRM, and a long (315-amino-acid) C-terminal domain composed predominantly of alternating serine and arginine residues.	Arginine	299-307	serine and arginine rich splicing factor 4	Homo sapiens	28-33
8415574-1	1993	Thrombin displays remarkable specificity, effecting the removal of fibrinopeptides A and B of fibrinogen through the selective cleavage of two Arg-Gly bonds between the 181 Arg/Lys-Xaa bonds in fibrinogen.	Arginine	143-146	coagulation factor II, thrombin	Homo sapiens	0-8
8415574-1	1993	Thrombin displays remarkable specificity, effecting the removal of fibrinopeptides A and B of fibrinogen through the selective cleavage of two Arg-Gly bonds between the 181 Arg/Lys-Xaa bonds in fibrinogen.	Arginine	173-176	coagulation factor II, thrombin	Homo sapiens	0-8
7686366-6	1993	Occupancy of glycoprotein IIb-IIIa in the membranes with RGD (Arg-Gly-Asp)-containing peptides reversibly exposed neoantigenic epitopes and fibrinogen-binding sites in the receptor.	Arginine	62-65	fibrinogen beta chain	Homo sapiens	140-150
8389669-2	1993	The wild-type of p53 protein exists as at least two forms of variants among human populations, ascribed to amino acid replacement at codon 72 of Arg by Pro.	Arginine	145-148	tumor protein p53	Homo sapiens	17-20
8389669-3	1993	In this study, we show that this germ line Arg-Pro polymorphism at codon 72 of the p53 gene is associated with genetically determined susceptibility to smoking-induced lung cancer; a susceptible genotype Pro/Pro has a 1.7-fold higher risk of this cancer compared with other genotypes.	Arginine	43-46	tumor protein p53	Homo sapiens	83-86
8393742-5	1993	Codon 191 is CAA (for glutamine) in the A-type esterase, and CGA (for arginine) in the B-type enzyme.	Arginine	70-78	chromogranin A	Homo sapiens	61-64
8388860-3	1993	In this study, we have examined the molecular mechanism of this enhancement through phagocyte receptors which recognize the Arg-Gly-Asp (RGD) peptide sequences contained within the FN molecule.	Arginine	124-127	fibronectin 1	Homo sapiens	181-183
8501149-10	1993	A heterozygous mutation of codon 201 of Gs alpha (GGT [Arg]-CAT [His]) was observed in a nodule from an adenomatous goiter.	Arginine	55-58	GNAS complex locus	Homo sapiens	40-48
7683646-9	1993	Although substitution of residues 54 and 55 with the analogous residues from IGF-I (Arg-Arg) abolished binding to the IGF-II/mannose 6-phosphate receptor, binding to IGFBPs was not substantially affected.	Arginine	84-87	insulin like growth factor 1	Homo sapiens	77-82
8397784-5	1993	Sequence comparison of the two molecules revealed that IGF-I has arginine at residues 55 and 56, while IGF-II has alanine and leucine, respectively, at these positions.	Arginine	65-73	insulin like growth factor 1	Homo sapiens	55-60
8318901-7	1993	Similarly, the high Km value of the EGFR pY peptide (Km of 104 microM) derives largely from the arginine residue at the +2 position of the peptide, since arginine to alanine single mutation at the -2 position of the EGFR peptide decreased the Km value 34-fold to 3 microM.	Arginine	96-104	epidermal growth factor receptor	Homo sapiens	36-40
8318901-7	1993	Similarly, the high Km value of the EGFR pY peptide (Km of 104 microM) derives largely from the arginine residue at the +2 position of the peptide, since arginine to alanine single mutation at the -2 position of the EGFR peptide decreased the Km value 34-fold to 3 microM.	Arginine	96-104	epidermal growth factor receptor	Homo sapiens	216-220
8318901-7	1993	Similarly, the high Km value of the EGFR pY peptide (Km of 104 microM) derives largely from the arginine residue at the +2 position of the peptide, since arginine to alanine single mutation at the -2 position of the EGFR peptide decreased the Km value 34-fold to 3 microM.	Arginine	154-162	epidermal growth factor receptor	Homo sapiens	36-40
8486712-1	1993	To determine the functional conformation of the Arg-Gly-Asp (RGD) sequence, we have constructed mutant proteins by inserting 4-12 amino acid residues from the RGD region of human fibronectin between Val74 and Asn75 of human lysozyme.	Arginine	48-51	fibronectin 1	Homo sapiens	179-190
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Arginine	43-46	vasoactive intestinal peptide	Rattus norvegicus	18-21
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Arginine	43-46	vasoactive intestinal peptide	Rattus norvegicus	53-56
7901784-8	1993	An antagonist for VIP receptor, [Lys, Pro, Arg, Tyr]-VIP inhibited the VIP-induced increase of plasma AVP, but had little effect on PACAP-induced increase of plasma AVP.	Arginine	43-46	vasoactive intestinal peptide	Rattus norvegicus	53-56
8337118-10	1993	HPA-4 (Pen, Yuk) as HPA1 is on GPIIIa but in a different location (Arg&lt;==&gt;Gln 143).	Arginine	67-70	heparanase	Homo sapiens	20-24
8496923-2	1993	In order to obtain selective suicide substrates of trypsin-like proteases including plasminogen activators, plasmin, and thrombin, a series of cyclopeptides cyclo[Arg or Lys-aB(CH2X)-Gly4], in which a substituted o- or m-aminobenzoyl group constitutes a latent electrophile, have been prepared.	Arginine	163-166	coagulation factor II, thrombin	Homo sapiens	121-129
8387813-3	1993	The latter is a highly electropositive surface near the C-terminal helix of thrombin abundant in arginine and lysine residues.	Arginine	97-105	coagulation factor II, thrombin	Homo sapiens	76-84
7683646-9	1993	Although substitution of residues 54 and 55 with the analogous residues from IGF-I (Arg-Arg) abolished binding to the IGF-II/mannose 6-phosphate receptor, binding to IGFBPs was not substantially affected.	Arginine	88-91	insulin like growth factor 1	Homo sapiens	77-82
7683860-2	1993	In this paper we report that the stimulation of the PI-PLC activity by myelin basic protein (MBP) requires arginine residues in peptide linkage.	Arginine	107-115	myelin basic protein	Bos taurus	71-91
8484387-1	1993	In eight healthy volunteers, basal and arginine-stimulated plasma glucose and growth hormone levels were determined during administration of a placebo and after 3 days of ibuprofen (800 mg four times daily).	Arginine	39-47	growth hormone 1	Homo sapiens	78-92
8488843-4	1993	Three hyperlipoproteinemic probands were carriers of the APOE*2(Val236--&gt;Glu) allele, the APOE*3(Cys112--&gt;Arg; Arg251--&gt;Gly) allele, or the APOE*1(Arg158--&gt;Cys; Leu252--&gt;Glu) allele.	Arginine	112-115	apolipoprotein E	Homo sapiens	93-99
8488843-6	1993	Family studies failed to demonstrate cosegregation between the new mutations and severe hyperlipoproteinemia, although a number of carriers for the APOE*3(Cys112--&gt;Arg; Arg251--&gt;Gly) allele and the APOE*1(Arg158--&gt;Cys; Leu252--&gt;Glu) allele expressed hypertriglyceridemia and/or hypercholesterolemia.	Arginine	167-170	apolipoprotein E	Homo sapiens	148-154
8488843-6	1993	Family studies failed to demonstrate cosegregation between the new mutations and severe hyperlipoproteinemia, although a number of carriers for the APOE*3(Cys112--&gt;Arg; Arg251--&gt;Gly) allele and the APOE*1(Arg158--&gt;Cys; Leu252--&gt;Glu) allele expressed hypertriglyceridemia and/or hypercholesterolemia.	Arginine	167-170	apolipoprotein E	Homo sapiens	148-152
7683860-2	1993	In this paper we report that the stimulation of the PI-PLC activity by myelin basic protein (MBP) requires arginine residues in peptide linkage.	Arginine	107-115	myelin basic protein	Bos taurus	93-96
7683860-6	1993	The arginyl residues of MBP were modified chemically with 1,2-cyclohexanedione, or enzymatically by cholera toxin which ADP-ribosylated arginyl groups, or by peptidylarginine deiminase which converted the guanidino group of arginine to the ureido group of citrulline.	Arginine	166-174	myelin basic protein	Bos taurus	24-27
7683860-10	1993	A role for "active" arginine in this MBP peptide is suggested by our data.	Arginine	20-28	myelin basic protein	Bos taurus	37-40
8100215-7	1993	Analysis of the coding sequence within exon 1, the most 5" exon within the lysyl oxidase gene, revealed that the PstI RFLP was due to a G--&gt;A transition resulting in a nonconservative arginine to glutamine substitution proximal to a propeptide cleavage domain encoded by exon 1 of the lysyl oxidase gene.	Arginine	187-195	serine peptidase inhibitor Kazal type 1	Homo sapiens	113-117
8389256-6	1993	The p53 point mutations in the three HCC cell lines from Japan resulted in the amino acid changes of cysteine for tyrosine in cell line HuH 7 at codon 220 (A:T--&gt;G:C), alanine for glycine in cell line HLF at codon 244 (G:C--&gt;C:G), and serine for arginine in cell line HLE at codon 249 (G:C--&gt;C:G).	Arginine	252-260	tumor protein p53	Homo sapiens	4-7
8492725-0	1993	Arginine blocks the inhibitory effect of hydrocortisone on circulating growth hormone levels in patients with acromegaly.	Arginine	0-8	growth hormone 1	Homo sapiens	71-85
7692338-0	1993	Effect of galanin and arginine, alone or in combination, on growth hormone secretion in adult patients treated with glucocorticoids.	Arginine	22-30	growth hormone 1	Homo sapiens	60-74
7692338-2	1993	Galanin, a 29-amino acid peptide, and arginine stimulate GH secretion through different hypothalamic mechanisms.	Arginine	38-46	growth hormone 1	Homo sapiens	57-59
8509718-3	1993	The arginine(3500)--&gt;glutamine mutation has been identified on the same haplotype of the apoB gene in several populations from North America and Europe, suggesting that it occurred on a single ancestral gene.	Arginine	4-12	apolipoprotein B	Homo sapiens	92-96
8509718-5	1993	The purpose of this paper is to report on a family where individuals show a dominantly inherited increase of plasma LDL associated with an independent arginine(3500)--&gt;glutamine mutation as determined by haplotype analysis using polymorphic markers of the apoB gene.	Arginine	151-159	apolipoprotein B	Homo sapiens	259-263
8509718-6	1993	The identification of these individuals is strong evidence that the arginine(3500)--&gt;glutamine mutation is causative for the defective binding of apoB-100.	Arginine	68-76	apolipoprotein B	Homo sapiens	149-157
7692338-3	1993	The aim of our study was to investigate the effect of arginine and galanin (alone or in combination) on GH secretion in 7 adult patients with nonendocrine diseases receiving chronic daily immunosuppressive glucocorticoid treatment (5 F, 2 M; mean age 48.4 +/- (SEM) 3.7 years).	Arginine	54-62	growth hormone 1	Homo sapiens	104-106
7692338-9	1993	In glucocorticoid-treated patients the GH peak after arginine (4.6 +/- 1.5 micrograms/l) was significantly (p &lt; 0.05) higher with respect to galanin (1.8 +/- 1.0 micrograms/l); after arginine + galanin the GH peak (8.2 +/- 2.3 micrograms/l) was significantly (p &lt; 0.05) enhanced with respect to either galanin or arginine alone.	Arginine	53-61	growth hormone 1	Homo sapiens	39-41
8492725-3	1993	infusion of hydrocortisone combined either with saline or arginine infusion on circulating GH levels in acromegaly.	Arginine	58-66	growth hormone 1	Homo sapiens	91-93
7692338-9	1993	In glucocorticoid-treated patients the GH peak after arginine (4.6 +/- 1.5 micrograms/l) was significantly (p &lt; 0.05) higher with respect to galanin (1.8 +/- 1.0 micrograms/l); after arginine + galanin the GH peak (8.2 +/- 2.3 micrograms/l) was significantly (p &lt; 0.05) enhanced with respect to either galanin or arginine alone.	Arginine	186-194	growth hormone 1	Homo sapiens	39-41
7692338-9	1993	In glucocorticoid-treated patients the GH peak after arginine (4.6 +/- 1.5 micrograms/l) was significantly (p &lt; 0.05) higher with respect to galanin (1.8 +/- 1.0 micrograms/l); after arginine + galanin the GH peak (8.2 +/- 2.3 micrograms/l) was significantly (p &lt; 0.05) enhanced with respect to either galanin or arginine alone.	Arginine	186-194	growth hormone 1	Homo sapiens	39-41
8492725-10	1993	After arginine pretreatment, GH levels were significantly enhanced compared with levels attained with hydrocortisone saline, and they were also significantly increased (peak, 167.5% +/- 27.7%) with respect to basal levels.	Arginine	6-14	growth hormone 1	Homo sapiens	29-31
7692338-10	1993	The GH response to arginine was not significantly different in normal and glucocorticoid-treated patients.	Arginine	19-27	growth hormone 1	Homo sapiens	4-6
8413832-9	1993	injection of L-arginine (0.5 and 1 mg), also the precursor for the biosynthesis of NO, resulted in dose-dependent increases in the plasma vasopressin concentration similar in magnitude to those caused by SNAP.	Arginine	13-23	arginine vasopressin	Rattus norvegicus	138-149
8492725-11	1993	Our data show that arginine blocks the inhibitory effect of acute and sustained hypercortisolism on circulating GH levels in acromegaly.	Arginine	19-27	growth hormone 1	Homo sapiens	112-114
8477724-0	1993	Arginine 53 is involved in head-group specificity of the active site of porcine pancreatic phospholipase A2.	Arginine	0-8	phospholipase A2 group IB	Homo sapiens	91-107
8332551-5	1993	In addition, the gamma-MSH sequence, contrary to salmon POMC, is present and contains three substitutions, namely a Ser, an Asn, and a Lys residue substituting the normally occurring mammalian Gly, Asp, and Arg residue, respectively.	Arginine	207-210	proopiomelanocortin	Homo sapiens	17-26
8463322-0	1993	Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.	Arginine	55-58	actinin alpha 1	Homo sapiens	154-167
8475085-7	1993	L-Arginine did not alter basal and IL-2-induced CRF release after 30 min of incubation but significantly elevated both basal and IL-2-induced CRF release when MBHs were incubated 30 min longer, presumably because the endogenous substrate had been depleted after the initial 30-min incubation period.	Arginine	0-10	interleukin 2	Homo sapiens	129-133
8476047-5	1993	This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P &lt; 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media.	Arginine	133-141	interleukin 6	Homo sapiens	62-66
8476047-8	1993	When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P &lt; 0.05).	Arginine	133-141	interleukin 6	Homo sapiens	170-174
7680289-1	1993	Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine.	Arginine	158-168	nitric oxide synthase 3	Bos taurus	0-38
7680289-1	1993	Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine.	Arginine	158-168	nitric oxide synthase 3	Bos taurus	40-45
7683269-6	1993	Inhibition of spreading of Ad2-infected KB cells on FN by the peptide Gly-Arg-Gly-Asp-Ser-Pro is partial, although it is complete in uninfected KB cells.	Arginine	74-77	fibronectin 1	Homo sapiens	52-54
8483912-6	1993	An Arg--&gt;Ile mutation at the basic-pair site after the C terminus of big ET-1 fully inhibited the formation of both big ET-1 and ET-1, indicating that processing at this site is an early event and that big ET-1 is an obligate intermediate for the synthesis of ET-1 in vivo.	Arginine	3-6	endothelin 1	Homo sapiens	76-80
8483912-6	1993	An Arg--&gt;Ile mutation at the basic-pair site after the C terminus of big ET-1 fully inhibited the formation of both big ET-1 and ET-1, indicating that processing at this site is an early event and that big ET-1 is an obligate intermediate for the synthesis of ET-1 in vivo.	Arginine	3-6	endothelin 1	Homo sapiens	123-127
8483912-6	1993	An Arg--&gt;Ile mutation at the basic-pair site after the C terminus of big ET-1 fully inhibited the formation of both big ET-1 and ET-1, indicating that processing at this site is an early event and that big ET-1 is an obligate intermediate for the synthesis of ET-1 in vivo.	Arginine	3-6	endothelin 1	Homo sapiens	123-127
8483912-6	1993	An Arg--&gt;Ile mutation at the basic-pair site after the C terminus of big ET-1 fully inhibited the formation of both big ET-1 and ET-1, indicating that processing at this site is an early event and that big ET-1 is an obligate intermediate for the synthesis of ET-1 in vivo.	Arginine	3-6	endothelin 1	Homo sapiens	123-127
8483912-6	1993	An Arg--&gt;Ile mutation at the basic-pair site after the C terminus of big ET-1 fully inhibited the formation of both big ET-1 and ET-1, indicating that processing at this site is an early event and that big ET-1 is an obligate intermediate for the synthesis of ET-1 in vivo.	Arginine	3-6	endothelin 1	Homo sapiens	123-127
8484722-3	1993	Like actin, the ADP-ribose-arthrin linkage was sensitive towards hydroxylamine treatment, indicating arginine as the amino acid acceptor.	Arginine	101-109	Actin 79B	Drosophila melanogaster	5-10
8475085-2	1993	Cytokines induce nitric oxide synthase (NOS), an enzyme that converts L-arginine into L-citrulline and nitric oxide (NO).	Arginine	70-80	nitric oxide synthase 2	Homo sapiens	17-38
8461464-1	1993	Divalent cation-dependent platelet adhesion to fibronectin (FN) is mediated by the integrin receptors alpha 5 beta 1 (GP Ic-IIa) and alpha IIb beta 3 (GP IIb-IIIa), which recognize the RGD (Arg-Gly-Asp) sequence in the cell-binding domain.	Arginine	190-193	fibronectin 1	Homo sapiens	47-58
8461464-1	1993	Divalent cation-dependent platelet adhesion to fibronectin (FN) is mediated by the integrin receptors alpha 5 beta 1 (GP Ic-IIa) and alpha IIb beta 3 (GP IIb-IIIa), which recognize the RGD (Arg-Gly-Asp) sequence in the cell-binding domain.	Arginine	190-193	fibronectin 1	Homo sapiens	60-62
8096183-2	1993	We have recently reported that streptavidin contains an Arg-Tyr-Asp-Ser (RYDS) sequence which exhibits structural homology to the Arg-Gly-Asp-Ser (RGDS) cell adhesion domain of fibronectin and other matrix-associated glycoproteins.	Arginine	56-60	fibronectin 1	Homo sapiens	177-188
8096183-2	1993	We have recently reported that streptavidin contains an Arg-Tyr-Asp-Ser (RYDS) sequence which exhibits structural homology to the Arg-Gly-Asp-Ser (RGDS) cell adhesion domain of fibronectin and other matrix-associated glycoproteins.	Arginine	56-59	fibronectin 1	Homo sapiens	177-188
8102543-7	1993	MAIN OUTCOME MEASURES: Fasting concentrations of glucose, insulin, and glucagon; and effect of arginine on insulin and glucagon secretion at the different blood glucose concentrations.	Arginine	95-103	insulin	Homo sapiens	107-114
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Arginine	118-128	nitric oxide synthase 2	Rattus norvegicus	0-31
8102543-9	1993	The mean (SEM) insulin response to arginine was reduced from 316 (101) to 129 (29) pmol/l (p &lt; 0.05) and when the patients were at the most hyperglycaemic from 1292 (316) to 474 (115) pmol/l (p &lt; 0.05).	Arginine	35-43	insulin	Homo sapiens	15-22
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Arginine	304-307	fibronectin 1	Homo sapiens	46-57
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Arginine	304-307	fibronectin 1	Homo sapiens	102-113
8468356-7	1993	The peptide specifically inhibited binding of fibronectin to gelatin or type I collagen and inhibited fibronectin-mediated adhesion of breast carcinoma and melanoma cells to gelatin or type I collagen substrates but not direct adhesion of the cells to fibronectin, which was inhibited by the peptide Gly-Arg-Gly-Asp-Ser.	Arginine	304-307	fibronectin 1	Homo sapiens	102-113
8466482-2	1993	A transition (G to A) was identified at codon 497 of EGFR cDNA, resulting in the substitution of a lysine for an arginine.	Arginine	113-121	epidermal growth factor receptor	Homo sapiens	53-57
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Arginine	118-128	nitric oxide synthase 2	Rattus norvegicus	33-37
8461023-4	1993	The codon 232 variant PrP (methionine to arginine) was documented in the CJD patients with typical clinical and pathological findings.	Arginine	41-49	prion protein	Homo sapiens	22-25
8384827-0	1993	Importance of the Arg-Gly-Asp triplet in human thrombin for maintenance of structure and function.	Arginine	18-21	coagulation factor II, thrombin	Homo sapiens	47-55
8329828-2	1993	The maximal plasma concentration of growth hormone (GH) was below 12 micrograms/l in two stimulation tests (arginine, insulin), but above 12 (24-90) micrograms/l after intravenous GHRH, 1 microgram/kg.	Arginine	108-116	growth hormone 1	Homo sapiens	36-50
8481768-3	1993	We studied the direct effects of the NO precursor L-arginine (L-ARG), as well as the NO donors molsidomine and sodium nitroprusside, on both the basal and stimulated release of CRH; the stimuli used were non-specific depolarisation with potassium chloride (KCl) and the specific cytokine, interleukin-1 beta (IL-1 beta; 100 U/ml).	Arginine	62-67	corticotropin releasing hormone	Rattus norvegicus	177-180
8481768-7	1993	However, L-ARG 10 and 100 microM were found to significantly inhibit the release of CRH induced by 40 mM KCl; CRH fell to 45% of its stimulated level at the higher dose of L-ARG.	Arginine	9-14	corticotropin releasing hormone	Rattus norvegicus	84-87
8481768-7	1993	However, L-ARG 10 and 100 microM were found to significantly inhibit the release of CRH induced by 40 mM KCl; CRH fell to 45% of its stimulated level at the higher dose of L-ARG.	Arginine	172-177	corticotropin releasing hormone	Rattus norvegicus	84-87
8481768-7	1993	However, L-ARG 10 and 100 microM were found to significantly inhibit the release of CRH induced by 40 mM KCl; CRH fell to 45% of its stimulated level at the higher dose of L-ARG.	Arginine	172-177	corticotropin releasing hormone	Rattus norvegicus	110-113
8384827-1	1993	Site-directed mutagenesis was employed to assess the importance of the Arg-Gly-Asp triplet that comprises residues 197 to 199 in the B-chain of thrombin.	Arginine	71-74	coagulation factor II, thrombin	Homo sapiens	144-152
8485050-4	1993	Two primers for polymerase chain reaction (PCR) were then designed, and a 394 bp PCR product was generated and sequenced, indicating that a stop codon (TGA) was substituted for an Arg codon (CGA) at amino acid position 584 of GPIIb, and resulted in a premature termination of translation and production of a shortened protein.	Arginine	180-183	chromogranin A	Homo sapiens	191-194
8452516-1	1993	Thrombin, the blood-clotting enzyme, is a serine proteinase with trypsin-like specificity and is able to cleave Arg-Xaa peptide bonds but only in a very limited number of substrates (and sites therein).	Arginine	112-115	coagulation factor II, thrombin	Homo sapiens	0-8
8477949-4	1993	Amylin did not alter glucose-stimulated secretion of insulin but significantly inhibited arginine-stimulated secretion of insulin (control: 20.9 +/- 1.4 pmol/min; amylin group: 14.8 +/- 1.6 pmol/min, p &lt; 0.05).	Arginine	89-97	insulin	Homo sapiens	122-129
7682342-14	1993	Using the methylated analog of arginine, NG-monomethyl-L-arginine, to inhibit NOS activity, it was demonstrated that TNF alpha/IFN-gamma-induced ATP depletion, GSSG efflux, and cytotoxicity were not dependent upon the stimulation of NOS.	Arginine	31-39	tumor necrosis factor	Mus musculus	117-126
8440915-7	1993	The region of fibronectin recognized by alpha 5 beta 1 contains the amino acid sequence arg-gly-asp (RGD).	Arginine	88-91	fibronectin 1	Homo sapiens	14-25
8316397-0	1993	Comparison of the potentiating effect of pyridostigmine, arginine and propranolol on the GHRH-induced GH release in short children.	Arginine	57-65	growth hormone releasing hormone	Homo sapiens	89-93
8316397-2	1993	Pyridostigmine and arginine induced a similar potentiating effect on GHRH-induced GH rise (Peak, mean +/- SEM: 56.9 +/- 12.8 and 48.6 +/- 8.5 micrograms/L, respectively vs 12.3 +/- 1.6 micrograms/L; p &lt; 0.05).	Arginine	19-27	growth hormone releasing hormone	Homo sapiens	69-73
8316397-5	1993	Our results confirm that pyridostigmine and arginine have a striking potentiating effect on the GHRH-induced GH rise in children and show that the tests with GHRH + PD and GH + H + ARG are ore reliable than that with GHRH + PROP to explore the secretory capacity of somatotroph cells.	Arginine	44-52	growth hormone releasing hormone	Homo sapiens	96-100
8316397-5	1993	Our results confirm that pyridostigmine and arginine have a striking potentiating effect on the GHRH-induced GH rise in children and show that the tests with GHRH + PD and GH + H + ARG are ore reliable than that with GHRH + PROP to explore the secretory capacity of somatotroph cells.	Arginine	181-184	growth hormone releasing hormone	Homo sapiens	96-100
8483792-3	1993	Peptides to which the sequence of Arg-Gly-Asp-Val (RGDV) had been added at the carboxy-terminus of (Lys-Arg)n, Lysn, or Argn also inhibited vWF binding.	Arginine	34-37	von Willebrand factor	Homo sapiens	140-143
8483792-3	1993	Peptides to which the sequence of Arg-Gly-Asp-Val (RGDV) had been added at the carboxy-terminus of (Lys-Arg)n, Lysn, or Argn also inhibited vWF binding.	Arginine	104-107	von Willebrand factor	Homo sapiens	140-143
8483792-5	1993	These findings indicate that the general formulae (Lys-Arg)n, Lysn, and Argn with an RGDV sequence inhibit the binding of fibrinogen to activated platelets as well as the binding of vWF to GPIb.	Arginine	55-58	von Willebrand factor	Homo sapiens	182-185
7682342-14	1993	Using the methylated analog of arginine, NG-monomethyl-L-arginine, to inhibit NOS activity, it was demonstrated that TNF alpha/IFN-gamma-induced ATP depletion, GSSG efflux, and cytotoxicity were not dependent upon the stimulation of NOS.	Arginine	31-39	interferon gamma	Mus musculus	127-136
8383455-0	1993	Endothelial L-arginine pathway and relaxations to vasopressin in canine basilar artery.	Arginine	12-22	arginine vasopressin	Homo sapiens	50-61
7680560-6	1993	NOS inhibitor-induced CBF slowing was also observed when cells were pre-stimulated with either bradykinin or substance P and was completely reversed by L-arginine or SNP but not by D-arginine.	Arginine	152-162	kininogen 1	Homo sapiens	95-105
7680560-6	1993	NOS inhibitor-induced CBF slowing was also observed when cells were pre-stimulated with either bradykinin or substance P and was completely reversed by L-arginine or SNP but not by D-arginine.	Arginine	152-162	tachykinin precursor 1	Homo sapiens	109-120
8429005-2	1993	We have employed site-directed mutagenesis to dissect one of the proposed heparin binding domains of avian LPL, which contains the sequence Arg-Lys-Asn-Arg (amino acids 281-284).	Arginine	140-143	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	107-110
8429005-2	1993	We have employed site-directed mutagenesis to dissect one of the proposed heparin binding domains of avian LPL, which contains the sequence Arg-Lys-Asn-Arg (amino acids 281-284).	Arginine	152-155	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	107-110
7679099-8	1993	These effects were severely decreased in clones expressing human IGF-I receptors in which the lysine residue in the ATP-binding site of the tyrosine kinase domain had been mutated to alanine or arginine.	Arginine	194-202	insulin like growth factor 1	Homo sapiens	65-70
8447417-3	1993	NG-nitro-L-arginine (L-NNA) abolished NO production in both preparations but only partly inhibited VIP release (45 +/- 8% at 8 Hz and 59 +/- 10% at 10 g stretch) and relaxation (62 +/- 5% and 35 +/- 6%); the effect of L-NNA was reversed by L-arginine but not D-arginine.	Arginine	9-19	vasoactive intestinal peptide	Rattus norvegicus	99-102
8094956-3	1993	We have undertaken a detailed NMR conformational study in a DMSOd6/H2O cryomixture at 278 K of the CCK analog H-Arg-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-PheNH2 (CCK9) which retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements.	Arginine	110-115	cholecystokinin	Homo sapiens	99-102
8383455-13	1993	In canine basilar artery, L-NAME and L-NMMA are nonselective inhibitors of both basal and stimulated production of nitric oxide, whereas L-NNA selectively inhibits vasopressin-induced activation of the L-arginine pathway.	Arginine	202-212	arginine vasopressin	Homo sapiens	164-175
8383455-1	1993	Experiments were designed to determine the role of the L-arginine pathway in endothelium-dependent relaxations to vasopressin.	Arginine	55-65	arginine vasopressin	Homo sapiens	114-125
8383455-8	1993	L-Arginine analogues inhibited relaxations to vasopressin but did not affect relaxations to a nitric oxide donor, molsidomine (SIN-1).	Arginine	0-10	arginine vasopressin	Homo sapiens	46-57
8383455-12	1993	These studies suggest that the relaxations to vasopressin are mediated by activation of the endothelial L-arginine pathway, leading to increased production of nitric oxide, with subsequent activation of guanylate cyclase in smooth muscle cells.	Arginine	104-114	arginine vasopressin	Homo sapiens	46-57
8382111-3	1993	All of the nine mutations in the p53 gene detected in HCC from Qi-Dong were clustered at the third base of codon 249, i.e. G:C to T:A, leading to an arginine to serine change.	Arginine	149-157	tumor protein p53	Homo sapiens	33-36
8447456-4	1993	In rings treated with TNF-alpha or LPS, L-arginine caused a concentration-dependent relaxation that was abolished by N omega-nitro-L-arginine [an inhibitor of nitric oxide (NO) synthase].	Arginine	40-50	tumor necrosis factor	Homo sapiens	22-31
7510502-4	1993	The recently demonstrated presence of 4 basic amino acids (1 arginine, 3 histidine) in the cleaved fragment of the amyloid precursor protein (APP) suggest us to hypothesise that this APP portion may represent the common constitutive element of the many morphologically different alterations found in the brains of senile demented patients.	Arginine	61-69	amyloid beta precursor protein	Homo sapiens	115-140
8447456-9	1993	Thus, in the porcine coronary artery without endothelium, TNF-alpha and LPS can induce an L-arginine-NO pathway.	Arginine	90-100	tumor necrosis factor	Homo sapiens	58-67
8444475-0	1993	A sequence variation in the human cystatin D gene resulting in an amino acid (Cys/Arg) polymorphism at the protein level.	Arginine	82-85	cystatin D	Homo sapiens	34-44
8448911-5	1993	The responsive secretion of insulin to glucagon or arginine loading was also low.	Arginine	51-59	insulin	Homo sapiens	28-35
8423095-0	1993	Neutralization of gamma interferon and tumor necrosis factor alpha blocks in vivo synthesis of nitrogen oxides from L-arginine and protection against Francisella tularensis infection in Mycobacterium bovis BCG-treated mice.	Arginine	116-126	tumor necrosis factor	Mus musculus	39-66
8493902-0	1993	Location of an essential arginine residue in the primary structure of pig aldose reductase.	Arginine	25-33	aldo-keto reductase family 1 member B	Sus scrofa	74-90
7680185-0	1993	Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: a structure-function analysis.	Arginine	67-70	vitronectin	Rattus norvegicus	14-25
8093615-2	1993	At variance with platelet alpha IIb beta 3 or endothelial cell alpha v beta 3 integrins, CD11b/CD18 interacts with a approximately 30-kDa plasmic fragment D (D30) of fibrinogen that lacks the Arg-Gly-Asp sequences in the A alpha chain and the carboxyl terminus of the gamma chain.	Arginine	192-195	integrin subunit beta 2	Homo sapiens	95-99
8422392-2	1993	I-FABP binds a single molecule of long-chain fatty acid and forms an ion-pair electrostatic interaction between the cationic side chain of arginine-106 and the anionic fatty acid carboxyl group.	Arginine	139-147	fatty acid binding protein 2	Homo sapiens	0-6
8416959-8	1993	The kinetic data obtained reveals that Kex1p preferentially cleaves the COOH-terminal arginine of peptides over the COOH-terminal lysine.	Arginine	86-94	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	39-44
8416959-9	1993	Insect-derived Kex1p processes alpha-factor-Lys-Arg, its known natural substrate, to mature active alpha-factor, and this maturation event takes place in a sequential manner.	Arginine	48-51	serine-type carboxypeptidase	Saccharomyces cerevisiae S288C	15-20
8488752-3	1993	Aminopeptidase activities were studied by measuring the rate of hydrolysis of the artificial substrates Lys-, Arg-, Asp- and Tyr-2-naphthylamides (fluorimetrically detected in triplicate).	Arginine	110-113	carboxypeptidase Q	Homo sapiens	0-14
8381821-16	1993	These results suggest that the arginine at codon 311 in c-erbA beta is crucial for the structural integrity required for dominant negative function.	Arginine	31-39	thyroid hormone receptor beta	Homo sapiens	56-67
8381821-17	1993	The ARG-311-HIS mutation may contribute to PRTH in patient G.H.	Arginine	4-7	thyroid hormone receptor beta	Homo sapiens	43-47
8445328-7	1993	Inhibition of .N = O synthesis by the L-arginine analogue of NG-monomethyl-L-arginine (NMA) resulted in a further increase of PGE2, TXB2, and IL-6 but not IL-1 and TNF-alpha production, indicating specific inhibitory effects of endogenous .N = O synthesis on the secretory activity of KCs.	Arginine	38-48	interleukin 6	Rattus norvegicus	142-146
8445328-7	1993	Inhibition of .N = O synthesis by the L-arginine analogue of NG-monomethyl-L-arginine (NMA) resulted in a further increase of PGE2, TXB2, and IL-6 but not IL-1 and TNF-alpha production, indicating specific inhibitory effects of endogenous .N = O synthesis on the secretory activity of KCs.	Arginine	38-48	tumor necrosis factor	Rattus norvegicus	164-173
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Arginine	159-162	major histocompatibility complex, class II, DR beta 1	Homo sapiens	41-45
8356909-0	1993	Chemical modification of an arginine residue in aldose reductase is enhanced by coenzyme binding: further evidence for conformational change during the reaction mechanism.	Arginine	28-36	aldo-keto reductase family 1 member B	Sus scrofa	48-64
8356909-1	1993	Chemical modification of pig muscle aldose reductase (ALR2) with the arginine specific reagent phenylglyoxal resulted in the inactivation of the enzyme.	Arginine	69-77	aldo-keto reductase family 1 member B	Sus scrofa	36-52
8356909-1	1993	Chemical modification of pig muscle aldose reductase (ALR2) with the arginine specific reagent phenylglyoxal resulted in the inactivation of the enzyme.	Arginine	69-77	aldo-keto reductase family 1 member B	Sus scrofa	54-58
8154332-0	1993	X-ray crystal structures of thrombin in complex with D-Phe-Pro-Arg and with small benzamidine- and arginine-based "non-peptidic" inhibitors.	Arginine	99-107	coagulation factor II, thrombin	Homo sapiens	28-36
7524285-0	1993	L-arginine/nitric oxide pathway: a possible signal transduction mechanism for the regulation of the chemokine IL-8 in human mesangial cells.	Arginine	0-10	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
8420495-2	1993	Recent studies have identified the presence of two unrelated chemotactic peptides in this fraction, ie, C5a/C5a des Arg and interleukin 8 (IL-8), and its related cytokines.	Arginine	116-119	complement C5a receptor 1	Homo sapiens	104-107
8317338-10	1993	These data suggest dependent on toxic oxygen and L-arginine products of neutrophils, the accumulation of which can be linked to cytokines (TNF alpha, IL-1), beta 2 integrins and endothelial adhesion molecules.	Arginine	49-59	tumor necrosis factor	Rattus norvegicus	139-148
8356923-4	1993	PAs specifically hydrolyse a single arginine-valine bond in plasminogen, an abundant and widely distributed plasma zymogen, to form the broad spectrum serine protease, plasmin.	Arginine	36-44	coagulation factor II, thrombin	Homo sapiens	151-166
8317306-4	1993	Treatment of cells with LPS and IFN-gamma caused a reduction in intracellular L-arginine concentration which was accompanied by increases in the levels of L-citrulline in both the cells and culture medium.	Arginine	78-88	toll-like receptor 4	Mus musculus	24-27
8317306-4	1993	Treatment of cells with LPS and IFN-gamma caused a reduction in intracellular L-arginine concentration which was accompanied by increases in the levels of L-citrulline in both the cells and culture medium.	Arginine	78-88	interferon gamma	Mus musculus	32-41
8317306-5	1993	These findings indicate that activation of J774 cells with LPS produces an increase in both L-arginine transport and nitrite synthesis.	Arginine	92-102	toll-like receptor 4	Mus musculus	59-62
8434604-3	1993	Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position alpha 1-9 in exon 7 to a premature termination signal for translation.	Arginine	156-164	chromogranin A	Homo sapiens	147-150
8420495-2	1993	Recent studies have identified the presence of two unrelated chemotactic peptides in this fraction, ie, C5a/C5a des Arg and interleukin 8 (IL-8), and its related cytokines.	Arginine	116-119	complement C5a receptor 1	Homo sapiens	108-111
8420495-4	1993	RESULTS: The concentrations of C5a/C5a des Arg and IL-8 were more significantly increased in the horny-tissue extracts from lesional skin than in those from noninflammatory orthokeratotic skin (P &lt; .01).	Arginine	43-46	complement C5a receptor 1	Homo sapiens	31-34
8503693-0	1993	Surprisingly high levels of anaphylatoxin C5a des Arg are extractable from psoriatic scales.	Arginine	50-53	complement C5a receptor 1	Homo sapiens	42-45
8420495-4	1993	RESULTS: The concentrations of C5a/C5a des Arg and IL-8 were more significantly increased in the horny-tissue extracts from lesional skin than in those from noninflammatory orthokeratotic skin (P &lt; .01).	Arginine	43-46	complement C5a receptor 1	Homo sapiens	35-38
8503693-2	1993	Anaphylatoxin C5a des Arg was quantified using a novel sandwich enzyme-linked immunosorbent assay (ELISA) using neoepitope-specific monoclonal antibodies.	Arginine	22-25	complement C5a receptor 1	Homo sapiens	14-17
8503693-3	1993	Alkali was about five to eight times more efficient than PBS in extracting C5a des Arg from scales, probably via dissociation of bound C5a des Arg.	Arginine	83-86	complement C5a receptor 1	Homo sapiens	75-78
8420495-5	1993	The increase of C5a/C5a des Arg concentration was specific to the lesional scale extracts, but showed a rather wide range of variation.	Arginine	28-31	complement C5a receptor 1	Homo sapiens	16-19
8503693-3	1993	Alkali was about five to eight times more efficient than PBS in extracting C5a des Arg from scales, probably via dissociation of bound C5a des Arg.	Arginine	83-86	complement C5a receptor 1	Homo sapiens	135-138
8503693-3	1993	Alkali was about five to eight times more efficient than PBS in extracting C5a des Arg from scales, probably via dissociation of bound C5a des Arg.	Arginine	143-146	complement C5a receptor 1	Homo sapiens	75-78
8420495-5	1993	The increase of C5a/C5a des Arg concentration was specific to the lesional scale extracts, but showed a rather wide range of variation.	Arginine	28-31	complement C5a receptor 1	Homo sapiens	20-23
8503693-3	1993	Alkali was about five to eight times more efficient than PBS in extracting C5a des Arg from scales, probably via dissociation of bound C5a des Arg.	Arginine	143-146	complement C5a receptor 1	Homo sapiens	135-138
8503693-4	1993	C5a des Arg concentration in scales from three patients suffering from psoriasis vulgaris varied between 2.5 and 4.6 ng/mg scale.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
8420495-11	1993	CONCLUSION: Based on these results, we speculate that, although IL-8 may exert a synergistic effect with C5a/C5a des Arg in the induction of transepidermal leukocyte chemotaxis, it constitutes a proinflammatory cytokine that is involved in the production of the persistent inflammatory changes characterized by a T-lymphocyte infiltration.	Arginine	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
8503693-6	1993	The biological activity of alkali-extractable C5a des Arg, i.e. chemotaxis, was preserved.	Arginine	54-57	complement C5a receptor 1	Homo sapiens	46-49
8503693-7	1993	The concentration of C5a des Arg relative to the concentration of albumin was taken as a parameter of the degree of complement activation in the psoriatic lesions, and was found to be more than six times higher than values attained in serum after maximum complement activation by zymosan.	Arginine	29-32	complement C5a receptor 1	Homo sapiens	21-24
8420495-11	1993	CONCLUSION: Based on these results, we speculate that, although IL-8 may exert a synergistic effect with C5a/C5a des Arg in the induction of transepidermal leukocyte chemotaxis, it constitutes a proinflammatory cytokine that is involved in the production of the persistent inflammatory changes characterized by a T-lymphocyte infiltration.	Arginine	117-120	complement C5a receptor 1	Homo sapiens	109-112
8420495-12	1993	In contrast, C5a/C5a des Arg seems to be generated only in the inflammatory lesional skin under specific circumstances that preferentially favor complement activation and also seems to play a major role in the induction of cyclic transepidermal leukocyte chemotaxis from "squirting papillae."	Arginine	25-28	complement C5a receptor 1	Homo sapiens	13-16
8420495-12	1993	In contrast, C5a/C5a des Arg seems to be generated only in the inflammatory lesional skin under specific circumstances that preferentially favor complement activation and also seems to play a major role in the induction of cyclic transepidermal leukocyte chemotaxis from "squirting papillae."	Arginine	25-28	complement C5a receptor 1	Homo sapiens	17-20
8364096-2	1993	The fibronectin cell binding domain -Arg-Gly-Asp-Ser- (-RGDS-) localizes at the junction of hydrophobicity and hydrophilicity.	Arginine	37-40	fibronectin 1	Homo sapiens	4-15
8019921-4	1993	Direct sequencing showed a G-A point mutation at position 2818 of exon 7 responsible for an arginine-histidine substitution at position 840 of the androgen receptor.	Arginine	92-100	androgen receptor	Homo sapiens	147-164
8435324-2	1993	The mutation responsible was a de novo alpha 28 Arg--&gt;Cys substitution (CGT--&gt;TGT) in spectrin, a mutation known to cause hereditary elliptocytosis or hereditary pyropoikilocytosis.	Arginine	48-51	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	84-87
7679657-1	1993	When islets were cultured with interleukin-1 beta (1 or 100 pmol/l) for 12 h in arginine-containing medium, cyclic GMP levels were increased 1.6- and 4.5-fold respectively.	Arginine	80-88	interleukin 1 beta	Rattus norvegicus	31-49
7679657-2	1993	The arginine analogue, N-omega-nitro-L-arginine methyl ester, which blocks nitric oxide formation and partially reverses inhibition of insulin secretion by 100 pmol/l interleukin-1 beta, largely, but not completely, blocked generation of cyclic GMP.	Arginine	4-12	interleukin 1 beta	Rattus norvegicus	167-185
7679657-7	1993	Both low- and high-dose interleukin-1 beta treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP.	Arginine	66-74	interleukin 1 beta	Rattus norvegicus	24-42
7679657-7	1993	Both low- and high-dose interleukin-1 beta treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP.	Arginine	115-123	interleukin 1 beta	Rattus norvegicus	24-42
7679657-3	1993	Treatment of islets with 100 pmol/l interleukin-1 beta for 12 h significantly decreased islet cyclic AMP generation in the absence of isobutylmethylxanthine (from 13.1 +/- 0.7 to 9.3 +/- 0.8 fmol/micrograms islet protein), this fall was arginine-dependent and may have resulted from an effect on a cyclic AMP phosphodiesterase, since it was masked if isobutylmethylxanthine was present.	Arginine	237-245	interleukin 1 beta	Rattus norvegicus	36-54
8148156-2	1993	To evaluate the role of this sequence in mediating the intracellular localization and biological activity of bFGF, basic residues Lys-27, Lys-30, and Arg-31 were changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Arginine	150-153	fibroblast growth factor 2	Homo sapiens	109-113
8357330-5	1993	Bradykinin is a potent activator of the L-arginine nitric oxide system (endothelium-derived relaxing factor).	Arginine	40-50	kininogen 1	Homo sapiens	0-10
8262472-4	1993	GH secretion in response to pharmacological stimuli (insulin, arginine and/or L-Dopa) was evaluated when growth failure occurred.	Arginine	62-70	growth hormone 1	Homo sapiens	0-2
8380785-5	1993	Sequencing analysis revealed a single-base mutation at codon 273 from CGT to CAT(Arg--&gt;His) and immunocytochemical studies provided evidence that the p53 protein was overexpressed in this cell line.	Arginine	81-84	tumor protein p53	Homo sapiens	153-156
7510003-4	1993	For example, human endothelin-1 (ET-1) precursor possesses a typical furin cleavage site motif (Arg-X-Lys/Arg-Arg) at the following residues: Arg32-Ser33-Lys34-Arg35 and Arg72-Ser73-Lys74-Arg75.	Arginine	96-99	endothelin 1	Homo sapiens	19-31
7510003-4	1993	For example, human endothelin-1 (ET-1) precursor possesses a typical furin cleavage site motif (Arg-X-Lys/Arg-Arg) at the following residues: Arg32-Ser33-Lys34-Arg35 and Arg72-Ser73-Lys74-Arg75.	Arginine	106-109	endothelin 1	Homo sapiens	19-31
8230355-7	1993	Perioperative supplement with arginine significantly enhanced the immune function of patients with obstructive jaundice, the mechanism being related to increased IL-2 production and IL-2R expression.	Arginine	30-38	interleukin 2	Homo sapiens	162-166
8476653-1	1993	p53 gene which is known as a tumor suppressor gene locates in chromosome 17p and has a polymorphism at codon 72 (Arginine CGC--&gt;Proline CCC).	Arginine	113-121	tumor protein p53	Homo sapiens	0-3
8098250-3	1993	We demonstrate that arginine at position 192 specifies high activity PON whereas a glutamine specifies the low activity variant.	Arginine	20-28	paraoxonase 1	Homo sapiens	69-72
1332957-6	1992	These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	66-74
8419922-1	1993	Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine.	Arginine	120-128	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
1281426-11	1992	Three arginines are important for angiogenesis: mutation of Arg-5, Arg-33, or Arg-66 dramatically reduces the angiogenic potency of angiogenin on the chicken embryo chorioallantoic membrane.	Arginine	6-15	ribonuclease A family member k6	Gallus gallus	132-142
1281426-11	1992	Three arginines are important for angiogenesis: mutation of Arg-5, Arg-33, or Arg-66 dramatically reduces the angiogenic potency of angiogenin on the chicken embryo chorioallantoic membrane.	Arginine	60-63	ribonuclease A family member k6	Gallus gallus	132-142
1281426-11	1992	Three arginines are important for angiogenesis: mutation of Arg-5, Arg-33, or Arg-66 dramatically reduces the angiogenic potency of angiogenin on the chicken embryo chorioallantoic membrane.	Arginine	67-70	ribonuclease A family member k6	Gallus gallus	132-142
1281426-11	1992	Three arginines are important for angiogenesis: mutation of Arg-5, Arg-33, or Arg-66 dramatically reduces the angiogenic potency of angiogenin on the chicken embryo chorioallantoic membrane.	Arginine	67-70	ribonuclease A family member k6	Gallus gallus	132-142
1460031-10	1992	We conclude that the residues Lys-57, Arg-58, and Trp-67 contribute to the structure of the PCh-binding site of human CRP.	Arginine	38-41	C-reactive protein	Homo sapiens	118-121
1479591-0	1992	Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen.	Arginine	57-60	fibrinogen beta chain	Homo sapiens	85-95
1280257-1	1992	Brain nitric oxide synthase (NOS), which utilizes NADPH and calcium/calmodulin as cofactors for metabolizing L-arginine to nitric oxide (NO) and L-citrulline, contains recognition sites for the flavins FAD and FMN.	Arginine	109-119	nitric oxide synthase 2	Homo sapiens	6-27
1332957-6	1992	These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	250-258
1332957-6	1992	These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin.	Arginine	27-30	fibrinogen beta chain	Homo sapiens	264-274
1332957-6	1992	These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	250-258
1451011-5	1992	These acidic proteins can affect the surface properties of collagen fibril, and BSP, having the cell-attachment sequence Arg-Gly-Asp, possibly mediates interaction between collagen fibril and cells.	Arginine	121-124	integrin binding sialoprotein	Homo sapiens	80-83
1281941-9	1992	reduced the BK-, but not the CAP- and/or RCM-induced pain responses which suggests that an L-arginine-derived NO or related compound is involved in BK activation of perivascular nociceptors.	Arginine	91-101	kininogen 1	Canis lupus familiaris	148-150
1286934-2	1992	One such defensin, NP-1, isolated from rabbit neutrophils, has been shown to consist of 33 amino acids rich in arginine and cysteine residues.	Arginine	111-119	corticostatin-3	Oryctolagus cuniculus	19-23
1304601-4	1992	Furthermore, the production of macrophage-activating factor (MAF) from rat splenocytes was higher in arginine-rich group than that of control group.	Arginine	101-109	MAF bZIP transcription factor	Rattus norvegicus	31-59
1304601-4	1992	Furthermore, the production of macrophage-activating factor (MAF) from rat splenocytes was higher in arginine-rich group than that of control group.	Arginine	101-109	MAF bZIP transcription factor	Rattus norvegicus	61-64
1304601-5	1992	AM from fraction IV of rats fed a stock diet had a higher arginase activity and showed a significant increase of phagocytosis following in vitro incubation with L-arginine (25 and 50 mM) for 24 h. From these results, the enhanced phagocytosis of AM by arginine-rich solution may be due to the increased phagocytosis of AM from fraction IV, in which the higher sensitivity of AM from fraction IV to arginine and the higher production of MAF from splenocytes following the infusion of arginine-rich solution participate.	Arginine	161-171	MAF bZIP transcription factor	Rattus norvegicus	436-439
1493798-4	1992	Chemical modification of lysine and arginine residues of TSP, but not treatment of the molecule with neuraminidase, resulted in a pronounced loss of binding at the cell surface.	Arginine	36-44	thrombospondin 1	Homo sapiens	57-60
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Arginine	27-30	formyl peptide receptor 1	Homo sapiens	275-279
1487709-8	1992	Endo-oligopeptidase A cleaved the bonds Phe-Ser of bradykinin, Met-Arg of BAM-12P and Arg-Arg of neurotensin as described for rabbit brain and heart and bovine brain enzymes.	Arginine	67-70	kininogen 1	Homo sapiens	51-61
1476614-4	1992	The sequence indicated that GIP is released from its precursor by cleavage at single arginine residues.	Arginine	85-93	gastric inhibitory polypeptide	Rattus norvegicus	28-31
1338816-5	1992	That L-arginine can ameliorate while L-NNA can exacerbate ToS, suggest that NO-LRF do play an adaptive role in the protective mechanism of the organism during ToS.	Arginine	5-15	zinc finger and BTB domain containing 7a	Rattus norvegicus	79-82
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Arginine	113-123	interferon gamma	Mus musculus	28-37
1280597-2	1992	In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta.	Arginine	49-59	interleukin 1 beta	Rattus norvegicus	209-227
1331047-6	1992	The two peptides, particularly IIFMGRVANP, directly enhanced the amidolytic activity of thrombin and Factor Xa on the synthetic substrate Boc-Ala-Gly-Arg-MCA (where Boc is t-butoxycarbonyl and MCA is 4-methylcoumarin), which corresponds to residues P3-P1 of the reactive site of antithrombin III, and also on other substrates due to increased Vmax.	Arginine	150-153	coagulation factor II, thrombin	Homo sapiens	88-96
1486864-9	1992	The p53 gene is a tumor-suppressor gene that can encode either a proline or an arginine in the 72nd residue.	Arginine	79-87	tumor protein p53	Homo sapiens	4-7
1416988-8	1992	Comparison of different synthetic peptide substrates showed Pim-1 to have a strong substrate preference for the peptide Lys-Arg-Arg-Ala-Ser*-Gly-Pro with an almost sixfold higher specificity constant kcat/Km over that of the substrate Kemptide (Leu-Arg-Arg-Ala-Ser*-Leu-Gly).	Arginine	124-127	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	60-65
1416988-11	1992	Therefore, under optimized in vitro conditions, the substrate recognition sequence for Pim-1 kinase is (Arg/Lys)3-X-Ser/Thr*-X", where X" is likely neither a basic nor a large hydrophobic residue.	Arginine	104-107	Pim-1 proto-oncogene, serine/threonine kinase	Bos taurus	87-92
1443599-1	1992	The angiotensin I-based peptide Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Glu-Glu-Ser yields angiotensin I (Ang I) and Leu-Glu-Glu-Ser upon hydrolysis by the human immunodeficiency virus type 1 (HIV-1) protease, but not by human renin.	Arginine	36-39	renin	Homo sapiens	231-236
1421398-0	1992	Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337--&gt;Thr and Arg-388--&gt;His).	Arginine	108-111	coagulation factor II, thrombin	Homo sapiens	0-11
1421398-0	1992	Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337--&gt;Thr and Arg-388--&gt;His).	Arginine	108-111	coagulation factor II, thrombin	Homo sapiens	64-75
1284063-2	1992	Several integrins recognize as ligands proteins containing the Arg-Gly-Asp (RGD) sequence, such as fibronectin, vitronectin, and laminin.	Arginine	63-67	fibronectin 1	Homo sapiens	99-110
1282482-2	1992	The primary structure of alligator substance P was established as: Arg-Pro-Arg-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.	Arginine	67-70	tachykinin precursor 1	Homo sapiens	35-46
1356929-3	1992	In vitro, pentoxifylline (PTOX) inhibits superoxide anion production when PMN are stimulated with an activated complement component (C5a Des Arg) or formyl peptides but only at concentrations not achieved in the circulation.	Arginine	141-144	complement C5a receptor 1	Homo sapiens	133-136
1356929-5	1992	Superoxide anion production, monitored by lucigenin-enhanced chemiluminescence, was inhibited by 40.5% +/- 8.0% (n = 8, P &lt; 0.009) for C5a Des Arg and 47.7% +/- 9.6% (n = 8, P &lt; 0.009) for formyl-methionylleucylphenylalanine stimulation 1.5 h after ingestion of 400 mg of PTOX in a slow-release tablet, with some inhibitory effects persisting at 5 h. There was a strong correlation between reduced PMN response to activated complement and plasma concentrations of three PTOX metabolites (P &lt; 0.05), but not with plasma concentrations of the parent drug.	Arginine	146-149	complement C5a receptor 1	Homo sapiens	138-141
1429834-1	1992	The four nucleolar proteins NOP1, SSB1, GAR1, and NSR1 of Saccharomyces cerevisiae share a repetitive domain composed of repeat units rich in glycine and arginine (GAR domain).	Arginine	154-162	rRNA methyltransferase NOP1	Saccharomyces cerevisiae S288C	28-32
1429834-1	1992	The four nucleolar proteins NOP1, SSB1, GAR1, and NSR1 of Saccharomyces cerevisiae share a repetitive domain composed of repeat units rich in glycine and arginine (GAR domain).	Arginine	154-162	H/ACA snoRNP pseudouridylase subunit GAR1	Saccharomyces cerevisiae S288C	40-44
1453124-2	1992	One specific mutation, a glutamine-for-arginine transformation at position 3500 of apo B-100, has been reported to produce FDB.	Arginine	39-47	apolipoprotein B	Homo sapiens	83-92
1430225-4	1992	This nucleotide substitution results in an Arg (CGA) to Gln (CAA) polymorphism at amino acid 143 of GPIIIa.	Arginine	43-46	chromogranin A	Homo sapiens	48-51
1430225-4	1992	This nucleotide substitution results in an Arg (CGA) to Gln (CAA) polymorphism at amino acid 143 of GPIIIa.	Arginine	43-46	integrin subunit beta 3	Homo sapiens	100-106
1287226-8	1992	Malnourished cancer patients have elevated levels of growth hormone that are further stimulated by arginine and insulin infusion.	Arginine	99-107	growth hormone 1	Homo sapiens	53-67
1328674-5	1992	Sites of protease cleavage were identified in the deduced amino acid sequence of mu 1 by determining the amino-terminal sequences of phi proteins: trypsin cleaves between arginine 584 and isoleucine 585, and chymotrypsin cleaves between tyrosine 581 and glycine 582.	Arginine	171-179	glutathione S-transferase mu 1	Homo sapiens	81-85
1280702-1	1992	L-arginine can be metabolized to nitric oxide (NO) by nitric oxide synthase (NOS) and to urea and L-ornithine by arginase.	Arginine	0-10	nitric oxide synthase 2	Homo sapiens	54-75
1384695-0	1992	Circular dichroism studies suggest that TAR RNA changes conformation upon specific binding of arginine or guanidine.	Arginine	94-102	RNA binding motif protein 8A	Homo sapiens	40-43
1282674-5	1992	Release of NO, induced by IL-1 beta, is dependent upon the availability of the substrate, L-arginine, and is suppressed by a competitive inhibitor, NG-monomethyl-L-arginine.	Arginine	90-100	interleukin 1 beta	Rattus norvegicus	26-35
1306774-0	1992	[Reaction of serum growth hormone in patients with endemic cretinism to arginine and clonidine in continuous excitement tests].	Arginine	72-80	growth hormone 1	Homo sapiens	19-33
1306774-1	1992	Reaction of serum growth hormone in cretins whose pituitary and thyroid function have returned to normal in IDD-control by using iodized salt to arginine and clonidine in continuous excitement tests ws observed.	Arginine	145-153	growth hormone 1	Homo sapiens	18-32
1445307-3	1992	Proteinase inhibition was dependent on the separation between sulfonate/carboxylate substituents, consistent with the hypothesis that negative charged ends of an inhibitor might form ionic bonds with Arg 8 and Arg 108 located at either end of the substrate-binding groove of the enzyme.	Arginine	200-203	endogenous retrovirus group K member 25	Homo sapiens	0-10
1445307-3	1992	Proteinase inhibition was dependent on the separation between sulfonate/carboxylate substituents, consistent with the hypothesis that negative charged ends of an inhibitor might form ionic bonds with Arg 8 and Arg 108 located at either end of the substrate-binding groove of the enzyme.	Arginine	210-213	endogenous retrovirus group K member 25	Homo sapiens	0-10
1384695-1	1992	Short basic peptides from the HIV Tat protein bind specifically to a bulge region in TAR RNA, with a single arginine residue providing the only sequence-specific contact.	Arginine	108-116	RNA binding motif protein 8A	Homo sapiens	85-88
1384695-4	1992	Here we confirm this observation using single arginine-containing peptides and show that arginine or guanidine binding also induces a conformational change in TAR.	Arginine	46-54	RNA binding motif protein 8A	Homo sapiens	159-162
1384695-4	1992	Here we confirm this observation using single arginine-containing peptides and show that arginine or guanidine binding also induces a conformational change in TAR.	Arginine	89-97	RNA binding motif protein 8A	Homo sapiens	159-162
1384695-5	1992	A peptide containing a single arginine within a stretch of histidines (CYHHHRHHHHHA) shows pH-dependent binding and a corresponding change in TAR conformation, as detected by a decrease in the CD signal at 265 nm.	Arginine	30-38	RNA binding motif protein 8A	Homo sapiens	142-145
1384695-6	1992	Arginine and guanidine, which bind to TAR with apparent Kd"s of approximately 1.5 mM, induce similar CD changes.	Arginine	0-8	RNA binding motif protein 8A	Homo sapiens	38-41
1384695-8	1992	Mutants of TAR that abolish specific binding (a U--&gt;C substitution in the three-nucleotide bulge, a deletion of the bulge, or an A-U to U-A base pair change above the bulge) show no change in the CD signal upon binding of peptides, arginine, or guanidine.	Arginine	235-243	RNA binding motif protein 8A	Homo sapiens	11-14
1382596-11	1992	Conversion of the active rPAI-1 to the latent form was influenced by temperature and additives including sucrose, EDTA, and arginine.	Arginine	124-132	serpin family E member 1	Rattus norvegicus	25-31
1397292-1	1992	The amino acid sequence, Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1, is thought to be a consensus processing site for a constitutive secretory pathway in non-endocrine cells.	Arginine	25-28	acetyl-CoA:L-glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	39-50
1448779-3	1992	Three of the severe vWD patients were found to be heterozygous for a nonsense mutation: CGA Arg 2535--&gt;TGA Stop.	Arginine	92-95	chromogranin A	Homo sapiens	88-91
1381292-1	1992	Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence SFLLRNPNDKYEPF.	Arginine	33-41	coagulation factor II, thrombin	Homo sapiens	0-8
1384465-2	1992	Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide.	Arginine	210-220	interleukin 1 beta	Homo sapiens	36-55
1384465-2	1992	Treatment of pancreatic islets with interleukin 1 (IL-1) results in a time-dependent inhibition of glucose-stimulated insulin secretion which has recently been demonstrated to be dependent on the metabolism of L-arginine to nitric oxide.	Arginine	210-220	insulin	Homo sapiens	118-125
1417782-6	1992	The second intron interrupts the canonical Asp-Arg-Tyr sequence, which is located at the end of the third transmembrane domain of the heptahelical receptors, as with the substance P, substance K, dopamine D2 and dopamine D3 receptor genes.	Arginine	47-50	tachykinin precursor 1	Bos taurus	170-181
1417782-6	1992	The second intron interrupts the canonical Asp-Arg-Tyr sequence, which is located at the end of the third transmembrane domain of the heptahelical receptors, as with the substance P, substance K, dopamine D2 and dopamine D3 receptor genes.	Arginine	47-50	tachykinin precursor 1	Bos taurus	183-194
1402389-8	1992	Coincubation with LPS, however, resulted in marked inhibition of pHi recovery at L-arginine concentrations as low as 12.5 microM.	Arginine	81-91	toll-like receptor 4	Mus musculus	18-21
1283393-1	1992	A new artificial cell adhesive protein was engineered by grafting the Arg-Gly-Asp (RGD) sequence, the minimal recognition signal of fibronectin for interaction with integrins, to a calpastatin segment by in vitro mutagenesis.	Arginine	70-73	fibronectin 1	Homo sapiens	132-143
1402389-11	1992	The L-arginine-dependent inhibition was apparent within 60 min of exposure to LPS, in both freshly harvested cells and cells preincubated for 2 h in the absence of L-arginine and then exposed to both L-arginine and LPS.	Arginine	4-14	toll-like receptor 4	Mus musculus	78-81
1479149-7	1992	Also ARG coadministration potentiated the GHRH-induced GH release in both groups (p &lt; 0.0001) but in this case the elderly"s responses overlapped with the young"s.	Arginine	5-8	growth hormone releasing hormone	Homo sapiens	42-46
1402389-11	1992	The L-arginine-dependent inhibition was apparent within 60 min of exposure to LPS, in both freshly harvested cells and cells preincubated for 2 h in the absence of L-arginine and then exposed to both L-arginine and LPS.	Arginine	4-14	toll-like receptor 4	Mus musculus	215-218
1402389-12	1992	Under conditions mimicking the in vivo setting, LPS-stimulated L-arginine metabolism impairs m phi pHi regulation.	Arginine	63-73	toll-like receptor 4	Mus musculus	48-51
1326547-0	1992	Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain.	Arginine	0-3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	23-75
1357118-2	1992	The natural amino acid at this position (arginine in GluR2 but glutamine in GluR1, GluR3, and GluR4) determines both the ability to pass outward current and the divalent cation permeability of kainate-activated receptor channels.	Arginine	41-49	glutamate ionotropic receptor AMPA type subunit 4	Homo sapiens	94-99
1479739-2	1992	BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK).	Arginine	55-58	kininogen 1	Homo sapiens	0-2
1479739-2	1992	BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK).	Arginine	55-58	kininogen 1	Homo sapiens	60-62
1479739-2	1992	BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK).	Arginine	55-58	kininogen 1	Homo sapiens	60-62
1479739-2	1992	BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK).	Arginine	55-58	kininogen 1	Homo sapiens	60-62
1458057-8	1992	Indeed, incubation of purified ETB with endopeptidase Arg-C resulted in degradation of the 45-kDa ETB, giving rise to the 35-kDa species by a specific cleavage at Arg64.	Arginine	54-57	endothelin receptor type B	Homo sapiens	31-34
1458057-8	1992	Indeed, incubation of purified ETB with endopeptidase Arg-C resulted in degradation of the 45-kDa ETB, giving rise to the 35-kDa species by a specific cleavage at Arg64.	Arginine	54-57	endothelin receptor type B	Homo sapiens	98-101
1326547-0	1992	Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain.	Arginine	12-15	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	23-75
1408801-4	1992	By systematic expression analysis of a number of chimeric genes composed of human and rat cDNAs, two strong translational suppression regions were mapped in the human DNA pol beta mRNA; one was named TSR-1, corresponding to CGG encoding arginine (arg) at position 4 and the other, termed TSR-2, is located between codons 153 and 199.	Arginine	237-245	TSR1 ribosome maturation factor	Homo sapiens	200-205
1408801-4	1992	By systematic expression analysis of a number of chimeric genes composed of human and rat cDNAs, two strong translational suppression regions were mapped in the human DNA pol beta mRNA; one was named TSR-1, corresponding to CGG encoding arginine (arg) at position 4 and the other, termed TSR-2, is located between codons 153 and 199.	Arginine	237-240	TSR1 ribosome maturation factor	Homo sapiens	200-205
1326547-8	1992	The corresponding residues in rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, Arg-257 and Arg-307, were mutated to alanine.	Arginine	94-97	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	40-92
1382056-9	1992	We located by molecular modeling an alpha-helical segment in lactoferrin on the exposed surface of the molecule containing the sequence Arg-X-X-Arg-Lys-X-Arg, which resembles the receptor recognition structure in apolipoprotein E (apoE).	Arginine	136-139	apolipoprotein E	Rattus norvegicus	213-229
1382056-9	1992	We located by molecular modeling an alpha-helical segment in lactoferrin on the exposed surface of the molecule containing the sequence Arg-X-X-Arg-Lys-X-Arg, which resembles the receptor recognition structure in apolipoprotein E (apoE).	Arginine	136-139	apolipoprotein E	Rattus norvegicus	231-235
1445373-2	1992	DNA analysis of the variant allele revealed a nucleotide substitution (transition) of C to T at codon 314 (CGT-TGT), and this mutation resulted in the replacement of an arginine by a cysteine (R314C).	Arginine	169-177	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	111-114
1419804-3	1992	Sequencing identified two potential missense mutations resulting in the amino acid substitutions Arg 834--&gt;Gln and Glu 875--&gt;Lys in the mature vWF subunit within an area of vWF where mutations in type IIA vWD have been reported.	Arginine	97-100	von Willebrand factor	Homo sapiens	149-152
1419804-3	1992	Sequencing identified two potential missense mutations resulting in the amino acid substitutions Arg 834--&gt;Gln and Glu 875--&gt;Lys in the mature vWF subunit within an area of vWF where mutations in type IIA vWD have been reported.	Arginine	97-100	von Willebrand factor	Homo sapiens	179-182
1419804-9	1992	The Cys 509--&gt;Arg substitution eliminates an intramolecular disulphide bridge formed by Cys 509 and Cys 695 which is important to maintain the configuration of vWF functional domains that interact with platelet glycoprotein Ib-IX.	Arginine	17-20	von Willebrand factor	Homo sapiens	163-166
1330642-4	1992	The cyclic GMP responses to bradykinin were suppressed with the same potency by L-arginine analogues in control and in forskolin-treated cells (IC50 of NG-monomethyl-L-arginine 2 microM, of nitro-L-arginine 0.7 microM).	Arginine	80-90	kininogen 1	Homo sapiens	28-38
1358935-0	1992	Generalized thyroid hormone resistance: identification of an arginine to cystine mutation in codon 315 of the c-erb A beta thyroid hormone receptor.	Arginine	61-69	thyroid hormone receptor beta	Homo sapiens	110-122
1512296-15	1992	As with L1 and Ng-CAM, the two chains of Bravo are generated from an intact polypeptide by cleavage at identical locations and conserved sites within all three molecules (Ser-Arg/Lys-Arg).	Arginine	175-178	L1 cell adhesion molecule	Gallus gallus	15-21
1512296-15	1992	As with L1 and Ng-CAM, the two chains of Bravo are generated from an intact polypeptide by cleavage at identical locations and conserved sites within all three molecules (Ser-Arg/Lys-Arg).	Arginine	183-186	L1 cell adhesion molecule	Gallus gallus	15-21
1500182-7	1992	NG-methyl-L-arginine inhibited the in vivo generation of reactive nitrogen intermediates by tumor necrosis factor in a dose-dependent manner, implying that these molecules were arginine derived.	Arginine	12-20	tumor necrosis factor	Mus musculus	92-113
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Arginine	91-94	sex hormone binding globulin	Homo sapiens	160-164
1355580-0	1992	Arginine abolishes the inhibitory effect of glucose on the growth hormone response to growth hormone-releasing hormone in man.	Arginine	0-8	growth hormone 1	Homo sapiens	59-73
1355580-0	1992	Arginine abolishes the inhibitory effect of glucose on the growth hormone response to growth hormone-releasing hormone in man.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	86-118
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	43-51	growth hormone 1	Homo sapiens	112-114
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	43-51	growth hormone 1	Homo sapiens	288-290
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	43-51	growth hormone releasing hormone	Homo sapiens	303-307
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	54-57	growth hormone 1	Homo sapiens	112-114
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	54-57	growth hormone 1	Homo sapiens	288-290
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	54-57	growth hormone releasing hormone	Homo sapiens	303-307
1355580-3	1992	The GH response to GHRH (peak, 11.6 +/- 1.8 micrograms/L) was inhibited by previous OG load (peak, 7.4 +/- 0.8 micrograms/L; P less than .02 v GHRH alone) and potentiated by Arg coadministration (peak, 36.2 +/- 8.8 micrograms/L; P less than .03 v GHRH alone).	Arginine	174-177	growth hormone 1	Homo sapiens	4-6
1355580-3	1992	The GH response to GHRH (peak, 11.6 +/- 1.8 micrograms/L) was inhibited by previous OG load (peak, 7.4 +/- 0.8 micrograms/L; P less than .02 v GHRH alone) and potentiated by Arg coadministration (peak, 36.2 +/- 8.8 micrograms/L; P less than .03 v GHRH alone).	Arginine	174-177	growth hormone releasing hormone	Homo sapiens	19-23
1355580-4	1992	The potentiating effect of Arg on the GHRH-induced GH increase was unaffected by previous OG load (peak, 30.4 +/- 6.9 micrograms/L).	Arginine	27-30	growth hormone releasing hormone	Homo sapiens	38-42
1355580-4	1992	The potentiating effect of Arg on the GHRH-induced GH increase was unaffected by previous OG load (peak, 30.4 +/- 6.9 micrograms/L).	Arginine	27-30	growth hormone 1	Homo sapiens	38-40
1355580-5	1992	In conclusion, our results show that Arg abolishes the inhibitory effect of OG administration on the GHRH-induced GH response in man.	Arginine	37-40	growth hormone releasing hormone	Homo sapiens	101-105
1355580-5	1992	In conclusion, our results show that Arg abolishes the inhibitory effect of OG administration on the GHRH-induced GH response in man.	Arginine	37-40	growth hormone 1	Homo sapiens	101-103
1357763-0	1992	Somatostatin binding reduced by ammonium acetate in the rat hippocampus can be reversed by treatment with N-carbamyl-L-glutamate plus L-arginine.	Arginine	134-144	somatostatin	Rattus norvegicus	0-12
1357763-6	1992	plus L-arginine (1 mmol/kg), which lead to the conversion of ammonia into urea, prevented the ammonium acetate-induced changes in somatostatin binding in this brain area.	Arginine	5-15	somatostatin	Rattus norvegicus	130-142
1325656-3	1992	VU-3 calmodulin is a site-directed mutant of VU-1 calmodulin that is identical in sequence except for the substitution of an arginine at position 115 and thus is incapable of methylation.	Arginine	125-133	calmodulin	Nicotiana tabacum	5-15
1330242-0	1992	Arginine induced insulin release in patients with newly onset non-insulin-dependent diabetes mellitus.	Arginine	0-8	insulin	Homo sapiens	17-24
1330242-1	1992	To examine the release of insulin in response to oral glucose, intravenous glucagon and intravenous arginine, we measured the levels of plasma glucose, immuno-reactive insulin (IRI) and C-peptide levels on fasting and following an oral glucose loading (OGTT), intravenous glucagon (GON) and arginine (ARG) infusion test in nine newly diagnosed non-insulin dependent diabetics.	Arginine	100-108	insulin	Homo sapiens	26-33
1330242-1	1992	To examine the release of insulin in response to oral glucose, intravenous glucagon and intravenous arginine, we measured the levels of plasma glucose, immuno-reactive insulin (IRI) and C-peptide levels on fasting and following an oral glucose loading (OGTT), intravenous glucagon (GON) and arginine (ARG) infusion test in nine newly diagnosed non-insulin dependent diabetics.	Arginine	291-299	insulin	Homo sapiens	26-33
1330242-1	1992	To examine the release of insulin in response to oral glucose, intravenous glucagon and intravenous arginine, we measured the levels of plasma glucose, immuno-reactive insulin (IRI) and C-peptide levels on fasting and following an oral glucose loading (OGTT), intravenous glucagon (GON) and arginine (ARG) infusion test in nine newly diagnosed non-insulin dependent diabetics.	Arginine	301-304	insulin	Homo sapiens	26-33
1510947-6	1992	Edman degradation of the two labeled peptides showed a single sequence His-Pro-Ile-([3H]X)-Arg corresponding to the pentapeptide His-Pro-Ile-Met-Arg 136-140 of SHBG sequence.	Arginine	145-148	sex hormone binding globulin	Homo sapiens	160-164
1386557-5	1992	Mapping of FN regions responsible for the proliferative signal was performed by stimulating melanoma cells with different FN proteolytic fragments and indicated that a significant mitogenic signal was provided by the M(r) 120,000 alpha-chymotrypsin fragment containing the Arg-Gly-Asp sequence.	Arginine	273-276	fibronectin 1	Homo sapiens	11-13
1386557-6	1992	The proliferation of melanoma cells to FN and to FN fragments was also significantly inhibited by peptides containing the Arg-Gly-Asp sequence.	Arginine	122-125	fibronectin 1	Homo sapiens	39-41
1637178-8	1992	The proteinase-treated r-EC-SOD C also lost triple arginine residues which are adjacent to double lysine residues.	Arginine	51-59	superoxide dismutase 3	Homo sapiens	25-31
1386557-6	1992	The proliferation of melanoma cells to FN and to FN fragments was also significantly inhibited by peptides containing the Arg-Gly-Asp sequence.	Arginine	122-125	fibronectin 1	Homo sapiens	49-51
1520273-10	1992	Our data are compatible with the following molecular model for the uncompetitive inhibition of PLAP and GCAP by L-Phe and L-Leu: after binding of a phosphorylated substrate to the active site, the guanidinium group of Arg-166 (normally involved in positioning phosphate) is redirected to the carboxy group of L-Leu (or L-Phe), thus stabilizing the inhibitor in the active site.	Arginine	218-221	alkaline phosphatase, placental	Homo sapiens	95-99
1637178-10	1992	It appeared that the proteolytic cleavage of the exteriorized lysine- and arginine-rich C-terminal end in vivo is a more important contributory factor to the formation of EC-SOD B and/or EC-SOD A.	Arginine	74-82	superoxide dismutase 3	Homo sapiens	171-177
1637178-10	1992	It appeared that the proteolytic cleavage of the exteriorized lysine- and arginine-rich C-terminal end in vivo is a more important contributory factor to the formation of EC-SOD B and/or EC-SOD A.	Arginine	74-82	superoxide dismutase 3	Homo sapiens	187-193
1502149-0	1992	Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis.	Arginine	27-30	apolipoprotein A1	Homo sapiens	0-17
1644811-3	1992	The carboxyl-terminal half of NSR1, consisting of two tandemly repeated putative RNA-binding domains and a glycine/arginine-rich domain, has 37% amino acid sequence identity with the same part of mammalian nucleolin, while no sequence similarities are found between their amino-terminal regions.	Arginine	115-123	scavenger receptor class F member 2	Homo sapiens	30-34
1502149-3	1992	The propositus was heterozygous; the coding region of his apoAI gene contained both the normal sequence and a single-base substitution changing the codon for residue 60 of the mature protein from CTG (leucine) to CGG (arginine).	Arginine	218-226	apolipoprotein A1	Homo sapiens	58-63
1502149-6	1992	Electrospray mass spectrometry of the purified 10-kDa material revealed components with mass corresponding to the N-terminal 88, 92, 93, and 94 residues of apoAI each with substitution of arginine for leucine.	Arginine	188-196	apolipoprotein A1	Homo sapiens	156-161
1473049-0	1992	A mediator derived from arginine mediates inhibitory junction potentials and relaxations in lower esophageal sphincter: an independent role for vasoactive intestinal peptide.	Arginine	24-32	vasoactive intestinal peptide	Canis lupus familiaris	144-173
1417919-4	1992	Chemical modification of this aminopeptidase by several amino acid-modifying agents indicated essential lysine, histidine, arginine, cysteine, and tyrosine residues.	Arginine	123-131	carboxypeptidase Q	Homo sapiens	30-44
1378360-10	1992	These observations indicate that in vivo endothelial injury of the rat carotid arteries induces the production of nitric oxide from L-arginine in the blood vessel wall, an effect which is potentiated by interleukin-1 beta.	Arginine	132-142	interleukin 1 beta	Rattus norvegicus	203-221
1332855-6	1992	The therapy, however, resolved the paradoxical responses of plasma ACTH and cortisol to arginine.	Arginine	88-96	proopiomelanocortin	Homo sapiens	67-71
1425152-9	1992	The maintenance of the responsiveness to the non-glucose secretagogue, arginine, as evaluated by the C-peptide levels, before and after correction of hyperglycemia, suggested improvement of beta-cell sensitivity to glucose after sulfonylurea treatment.	Arginine	71-79	insulin	Homo sapiens	101-110
1324289-6	1992	Removing L-arginine from the medium did not inhibit cytotoxicity or PGE2 secretion, but the listeriacidal activity specific to interferon-gamma plus lipopolysaccharide (LPS)-activated GM-CSF-derived macrophages was blocked by removal of L-arginine.	Arginine	237-247	interferon gamma	Mus musculus	127-143
1644930-6	1992	The other nonhereditary p53 mutation was a transition at codon 248 (CGG to CAG, arginine to glutamine) found in the lymphoblasts of a patient with a preleukemic syndrome and acute lymphoblastic leukemia (ALL) whose brother is a long-term survivor of ALL.	Arginine	80-88	tumor protein p53	Homo sapiens	24-27
1378832-1	1992	Nitric oxide, which accounts for the biological activity of endothelium-derived relaxing factor (EDRF), is synthesized in endothelial cells from L-arginine by nitric oxide synthase (NOS).	Arginine	145-155	nitric oxide synthase 2	Homo sapiens	159-180
1379068-2	1992	Nitric oxide synthase (NOS) catalyzes the five-electron oxidation of L-arginine to citrulline and nitric oxide.	Arginine	69-79	nitric oxide synthase 2	Homo sapiens	0-21
1379278-0	1992	Production of monoclonal antibodies against the human anaphylatoxin C5a des Arg and their application in the neoepitope-specific sandwich-ELISA for the quantification of C5a des Arg in plasma.	Arginine	76-79	complement C5a receptor 1	Homo sapiens	68-71
1379278-0	1992	Production of monoclonal antibodies against the human anaphylatoxin C5a des Arg and their application in the neoepitope-specific sandwich-ELISA for the quantification of C5a des Arg in plasma.	Arginine	178-181	complement C5a receptor 1	Homo sapiens	68-71
1379278-0	1992	Production of monoclonal antibodies against the human anaphylatoxin C5a des Arg and their application in the neoepitope-specific sandwich-ELISA for the quantification of C5a des Arg in plasma.	Arginine	178-181	complement C5a receptor 1	Homo sapiens	170-173
1379278-1	1992	A panel of ten murine monoclonal antibodies (MAbs) was raised against the human anaphylatoxin C5a des Arg.	Arginine	102-105	complement C5a receptor 1	Homo sapiens	94-97
1379278-3	1992	MAb 4A2E10E2 and MAb 3G3C4 were used as capture and detecting antibody, respectively, in a sandwich enzyme-linked immunosorbent assay (ELISA) for the quantification of C5a des Arg.	Arginine	176-179	complement C5a receptor 1	Homo sapiens	168-171
1379278-5	1992	The lack of interference by plasma components, in particular C5, suggested specificity for an epitope on C5a (des Arg) which is concealed in native C5 and exposed on the activation fragment only, i.e., a "neoepitope".	Arginine	114-117	complement C5a receptor 1	Homo sapiens	105-108
1379278-6	1992	The mean C5a des Arg level in EDTA-plasma from 25 healthy individuals assessed at a 1/20 dilution was 11.2 ng/ml (SD 3.4; range 6.4-16.8 ng/ml).	Arginine	17-20	complement C5a receptor 1	Homo sapiens	9-12
1379278-8	1992	Markedly elevated plasma levels of C5a des Arg were found in blood returning from the dialyzer following contact with cuprophane membranes.	Arginine	43-46	complement C5a receptor 1	Homo sapiens	35-38
1614463-5	1992	Islet function was assessed by measuring the plasma insulin responses to intravenous glucose and arginine and the plasma glucagon responses to hypoglycemia and arginine.	Arginine	97-105	insulin	Homo sapiens	52-59
1515063-1	1992	An aminopeptidase hydrolyzing 2-naphthylamides of Lys, Arg, Leu, Met, Phe and Tyr, as well as different di- to tridecapeptides, was purified from the cytosol of human erythrocytes.	Arginine	55-58	carboxypeptidase Q	Homo sapiens	3-17
1614463-9	1992	The acute plasma insulin responses to glucose and to arginine in the five patients were 23 +/- 13 and 26 +/- 10 microU per milliliter (168 +/- 94 and 184 +/- 70 pmol per liter), respectively, as compared with 58 +/- 6 and 37 +/- 8 microU per milliliter (416 +/- 44 and 267 +/- 61 pmol per liter) in the normal subjects.	Arginine	53-61	insulin	Homo sapiens	17-24
1614463-12	1992	The results of the hepatic-vein catheterization in one patient indicated that the transplanted islets released insulin and glucagon in response to arginine.	Arginine	147-155	insulin	Homo sapiens	111-118
1621097-0	1992	Conformation of the TAR RNA-arginine complex by NMR spectroscopy.	Arginine	28-36	RNA binding motif protein 8A	Homo sapiens	20-23
1621097-2	1992	The conformations of TAR RNA and of TAR with an arginine analog specifically bound at the binding site for the viral protein, Tat, were characterized by nuclear magnetic resonance (NMR) spectroscopy.	Arginine	48-56	RNA binding motif protein 8A	Homo sapiens	36-39
1621097-4	1992	Specificity in the arginine-TAR interaction appears to be derived largely from the structure of the RNA.	Arginine	19-27	RNA binding motif protein 8A	Homo sapiens	28-31
1632660-5	1992	The adherence of synovial cells to hyaluronidase treated cartilage slices in vitro was specifically inhibited by the synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, which is the adhesive portion of the fibronectin molecule.	Arginine	140-143	fibronectin 1	Homo sapiens	198-209
1618760-7	1992	In contrast, an unrelated Type B patient of European descent (proband 3) was heteroallelic for two missense mutations, a G to A transition in exon 2 which predicted a glycine to arginine substitution at ASM codon 242 (designated G242R), and an A to G transition in exon 3 which resulted in an asparagine to serine substitution at codon 383 (designated N383S).	Arginine	178-186	sphingomyelin phosphodiesterase 1	Homo sapiens	203-206
1425555-5	1992	The purity of the SAA1 and SAA1 des-Arg isoforms, thus isolated, was checked by immunochemical techniques and amino acid analysis.	Arginine	36-39	serum amyloid A1	Homo sapiens	27-31
18407098-6	1992	Metabolic intermediates can also affect GH secretion: arginine and hypoglycemia inhibit SS release, whereas hyperglycemia and free fatty acids (FFA) stimulate it.	Arginine	54-62	growth hormone 1	Homo sapiens	40-42
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Arginine	15-18	fibroblast growth factor 2	Homo sapiens	146-176
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Arginine	15-18	fibroblast growth factor 2	Homo sapiens	178-182
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Arginine	46-49	fibroblast growth factor 2	Homo sapiens	146-176
1378264-1	1992	Basic residues Arg-118, Lys-119, Lys-128, and Arg-129 within a putative heparin-binding and receptor-binding region of the 155-amino acid form of basic fibroblast growth factor (bFGF) have been changed to neutral glutamine residues by site-directed mutagenesis of the human bFGF cDNA.	Arginine	46-49	fibroblast growth factor 2	Homo sapiens	178-182
1376321-1	1992	Neutral endopeptidase 24.11 contains an active site arginine believed to function in substrate binding.	Arginine	52-60	membrane metalloendopeptidase	Homo sapiens	0-27
1376321-2	1992	This arginine is thought to form an ionic interaction with the COOH-terminal carboxylate of NEP substrates.	Arginine	5-13	membrane metalloendopeptidase	Homo sapiens	92-95
1375656-9	1992	IMPLICATIONS: Since .N = O synthesis can be competitively inhibited by L-arginine analogues, a possible pharmacologic modulation of .N = O production could potentially contribute to better management of toxic side effects seen in IL-2 cancer therapies.	Arginine	71-81	interleukin 2	Homo sapiens	230-234
1597458-14	1992	In particular the clustered N-terminal arginine residues, which resemble the arginine-rich receptor binding sequence in apoE, may be responsible for both the interaction of lactoferrin with its recognition site and the inhibition of the hepatic uptake of apoE-bearing lipoproteins.	Arginine	39-47	apolipoprotein E	Rattus norvegicus	120-124
1375940-7	1992	Cytochrome c, 2,6-dichlorophenolindophenol, and nitro blue tetrazolium inhibited NO synthase activity determined as formation of L-citrulline from 0.1 mM L-arginine in a concentration-dependent manner with half-maximal effects at 166, 41, and 7.3 microM, respectively.	Arginine	154-164	cytochrome c, somatic	Homo sapiens	0-12
1597458-14	1992	In particular the clustered N-terminal arginine residues, which resemble the arginine-rich receptor binding sequence in apoE, may be responsible for both the interaction of lactoferrin with its recognition site and the inhibition of the hepatic uptake of apoE-bearing lipoproteins.	Arginine	39-47	apolipoprotein E	Rattus norvegicus	255-259
1632677-6	1992	Production of IL-6 by regenerating liver KC was further increased (p less than 0.05) by placing these same KC in 10 microM L-arginine RPMI-1640 tissue culture media.	Arginine	123-133	interleukin 6	Homo sapiens	14-18
1509873-3	1992	However, the GH response to arginine was not significantly different between the two patient groups.	Arginine	28-36	growth hormone 1	Homo sapiens	13-15
1592874-0	1992	Arginine normalizes the growth hormone (GH) response to GH-releasing hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy.	Arginine	0-8	growth hormone 1	Homo sapiens	24-38
1380405-1	1992	NO synthase (NOS) catalyzes the oxidation of L-arginine to L-citrulline and nitric oxide (NO) or a NO-releasing compound.	Arginine	45-55	nitric oxide synthase 2	Homo sapiens	0-11
1380405-6	1992	Besides the conversion of L-arginine, type I NOS, Ca2+/calmodulin dependently, generates H2O2 and reduces cytochrome c/P450.	Arginine	26-36	cytochrome c, somatic	Homo sapiens	106-118
1358601-5	1992	Sequence analysis of the DNAs extracted from paraffin sections of pituitary, parathyroid, and pancreas tumors demonstrated the substitution of thymidine for cytidine in codon 201 of the Gs alpha gene that resulted in replacement of arginine (CGT) with cysteine (TGT) only in the pituitary adenoma, but not in the parathyroid and pancreas tumors.	Arginine	232-240	GNAS complex locus	Homo sapiens	186-194
1599422-2	1992	Mouse macrophages activated by interferon-gamma kill intracellular Leishmania by a process that depends on the generation of L-arginine-derived nitrogen oxidation products.	Arginine	125-135	interferon gamma	Mus musculus	31-47
1599422-11	1992	These results indicate that the ionophore-induced leishmanicidal activity occurs through a process similar to that evoked by interferon-gamma, i.e. the production of L-arginine-derived nitrogen oxidation products.	Arginine	166-176	interferon gamma	Mus musculus	125-141
1534057-6	1992	The increased amylin-insulin molar ratios of both n2STZ and n5STZ pancreases also occurred during infusions of 33.3 mM glucose and 10 mM arginine.	Arginine	137-145	insulin	Homo sapiens	21-28
1601986-5	1992	Beta cell reserve, as measured by glucose potentiation of arginine-induced insulin secretion, was significantly decreased in donors (maximal acute insulin response [AIRmax]: donors = 666 +/- 84 pM vs controls = 1,772 +/- 234 pM) while the PG50 (the glucose value at which the half-maximal response was observed) was the same in the two groups.	Arginine	58-66	insulin	Homo sapiens	75-82
1592874-0	1992	Arginine normalizes the growth hormone (GH) response to GH-releasing hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy.	Arginine	0-8	growth hormone 1	Homo sapiens	40-42
1592874-0	1992	Arginine normalizes the growth hormone (GH) response to GH-releasing hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	56-76
1592874-2	1992	The aim of our study was to evaluate the effect of arginine, a secretagogue that increases GH secretion acting at the hypothalamic level, probably by decreasing somatostatin tone, on GH-releasing hormone (GHRH)-induced GH secretion in three male and five female adult patients with nonendocrine disease who were receiving daily immunosuppressive glucocorticoid therapy.	Arginine	51-59	growth hormone 1	Homo sapiens	91-93
1592874-2	1992	The aim of our study was to evaluate the effect of arginine, a secretagogue that increases GH secretion acting at the hypothalamic level, probably by decreasing somatostatin tone, on GH-releasing hormone (GHRH)-induced GH secretion in three male and five female adult patients with nonendocrine disease who were receiving daily immunosuppressive glucocorticoid therapy.	Arginine	51-59	growth hormone releasing hormone	Homo sapiens	183-203
1592874-2	1992	The aim of our study was to evaluate the effect of arginine, a secretagogue that increases GH secretion acting at the hypothalamic level, probably by decreasing somatostatin tone, on GH-releasing hormone (GHRH)-induced GH secretion in three male and five female adult patients with nonendocrine disease who were receiving daily immunosuppressive glucocorticoid therapy.	Arginine	51-59	growth hormone releasing hormone	Homo sapiens	205-209
1592874-2	1992	The aim of our study was to evaluate the effect of arginine, a secretagogue that increases GH secretion acting at the hypothalamic level, probably by decreasing somatostatin tone, on GH-releasing hormone (GHRH)-induced GH secretion in three male and five female adult patients with nonendocrine disease who were receiving daily immunosuppressive glucocorticoid therapy.	Arginine	51-59	growth hormone 1	Homo sapiens	183-185
1592874-4	1992	GHRH-induced GH secretion was evaluated after 30-min iv infusion of saline (100 mL) or arginine (30 g) in 100 mL saline.	Arginine	87-95	growth hormone releasing hormone	Homo sapiens	0-4
1592874-6	1992	The GH responses to GHRH increased (P less than 0.05) after pretreatment with arginine compared to saline pretreatment in both normal subjects (GH peak, 36.6 +/- 4.0 micrograms/L) and steroid-treated patients (GH peak, 28.4 +/- 5.5 micrograms/L).	Arginine	78-86	growth hormone 1	Homo sapiens	4-6
1592874-6	1992	The GH responses to GHRH increased (P less than 0.05) after pretreatment with arginine compared to saline pretreatment in both normal subjects (GH peak, 36.6 +/- 4.0 micrograms/L) and steroid-treated patients (GH peak, 28.4 +/- 5.5 micrograms/L).	Arginine	78-86	growth hormone releasing hormone	Homo sapiens	20-24
1592874-6	1992	The GH responses to GHRH increased (P less than 0.05) after pretreatment with arginine compared to saline pretreatment in both normal subjects (GH peak, 36.6 +/- 4.0 micrograms/L) and steroid-treated patients (GH peak, 28.4 +/- 5.5 micrograms/L).	Arginine	78-86	growth hormone 1	Homo sapiens	20-22
1588125-8	1992	Finally, apoE3-Leiden has an arginine residue at 112 and has a repeat of seven extra amino acid residues just outside the binding domain.	Arginine	29-37	apolipoprotein E	Homo sapiens	9-14
1619387-8	1992	One missense mutation in the apoB gene (an Arg----Gln substitution at apoB amino acid 3500) is associated with very poor binding of apoB100 to the cellular LDL receptor.	Arginine	43-46	apolipoprotein B	Homo sapiens	29-33
1592874-6	1992	The GH responses to GHRH increased (P less than 0.05) after pretreatment with arginine compared to saline pretreatment in both normal subjects (GH peak, 36.6 +/- 4.0 micrograms/L) and steroid-treated patients (GH peak, 28.4 +/- 5.5 micrograms/L).	Arginine	78-86	growth hormone 1	Homo sapiens	20-22
1592874-7	1992	The GH responses to GHRH plus arginine were not significantly different in steroid-treated and normal subjects.	Arginine	30-38	growth hormone 1	Homo sapiens	4-6
1592874-8	1992	Thus, arginine is able to normalize the GH response to GHRH in patients receiving chronic glucocorticoid treatment.	Arginine	6-14	growth hormone 1	Homo sapiens	40-42
1592874-8	1992	Thus, arginine is able to normalize the GH response to GHRH in patients receiving chronic glucocorticoid treatment.	Arginine	6-14	growth hormone releasing hormone	Homo sapiens	55-59
1604562-0	1992	Serum NO2-/NO3- from oxidative L-arginine metabolism: a possible marker for small bowel allograft rejection.	Arginine	31-41	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
1619387-8	1992	One missense mutation in the apoB gene (an Arg----Gln substitution at apoB amino acid 3500) is associated with very poor binding of apoB100 to the cellular LDL receptor.	Arginine	43-46	apolipoprotein B	Homo sapiens	70-74
1619387-8	1992	One missense mutation in the apoB gene (an Arg----Gln substitution at apoB amino acid 3500) is associated with very poor binding of apoB100 to the cellular LDL receptor.	Arginine	43-46	apolipoprotein B	Homo sapiens	132-139
1581311-4	1992	The mutant with arginine in the second position bound particularly well to thrombin; its dissociation constant was 9-fold lower than that of wild-type recombinant hirudin.	Arginine	16-24	coagulation factor II, thrombin	Homo sapiens	75-83
1577789-7	1992	However, the Arg-Gly-Asp-containing synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro significantly inhibited cell attachment to MGP, whereas the control peptide Gly-Arg-Gly-Glu-Ser-Pro had minimal effect.	Arginine	13-16	matrix Gla protein	Bos taurus	121-124
1376108-6	1992	The studies indicate that the beta-turn is stabilized by the presence of a salt-bridge interaction between Asp-2 and Arg-4.	Arginine	117-120	beta-secretase 1	Homo sapiens	107-112
1577789-7	1992	However, the Arg-Gly-Asp-containing synthetic peptide Gly-Arg-Gly-Asp-Ser-Pro significantly inhibited cell attachment to MGP, whereas the control peptide Gly-Arg-Gly-Glu-Ser-Pro had minimal effect.	Arginine	58-61	matrix Gla protein	Bos taurus	121-124
1577789-8	1992	These data indicate that MGP may function in mediating cell attachment to the extracellular matrix via a receptor that requires intact Gla residues and that can be inhibited by Arg-Gly-Asp-containing peptides.	Arginine	177-180	matrix Gla protein	Bos taurus	25-28
1581297-1	1992	Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain.	Arginine	231-234	fibrinogen beta chain	Homo sapiens	0-10
1581297-1	1992	Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain.	Arginine	231-234	fibrinogen beta chain	Homo sapiens	34-44
1581297-1	1992	Fibrinogen Lille, a congenital dysfibrinogenemia, has been reported to arise from a mutation from Asp to Asn at position 7 of the A alpha chain of human fibrinogen, thereby reducing the thrombin-catalyzed rate of hydrolysis of the Arg(16)-Gly(17) peptide bond of this chain.	Arginine	231-234	coagulation factor II, thrombin	Homo sapiens	186-194
1581297-2	1992	Synthetic peptides of relevant portions of the wild-type and mutant A alpha chains were prepared, and the thrombin-catalyzed rates of hydrolysis of their Arg(16)-Gly(17) peptide bonds were determined.	Arginine	154-157	coagulation factor II, thrombin	Homo sapiens	106-114
1290488-1	1992	Hirulog-1 [D-Phe-Pro-Arg-Pro-[Gly]4-desulphohirudin-(53-64) (HV1)] was designed to bind by its first four and last 12 residues to the alpha-thrombin catalytic site and anion-binding exosite for fibrin(ogen) recognition respectively, with a [Gly]4 bridge and an Arg-Pro bond at the scissional position.	Arginine	21-24	coagulation factor II, thrombin	Homo sapiens	140-148
1580841-2	1992	Three members of one family and one person from another family were found to have a guanine-to-adenine transition mutation in the first nucleotide of codon 106 in the rhodopsin gene that results in a glycine-to-arginine change.	Arginine	211-219	rhodopsin	Homo sapiens	167-176
1569181-8	1992	The demonstration that this mutant Factor VIII has cofactor function when separated from vWf indicates that the dissociation of Factor VIII from vWf is an essential effect of Factor VIII light chain cleavage at arginine-1689.	Arginine	211-219	von Willebrand factor	Homo sapiens	145-148
1571548-7	1992	In addition to paired dibasic residues at the propeptide cleavage site, many proteins, including vWF, also contain an arginine at the P4 position.	Arginine	118-126	von Willebrand factor	Homo sapiens	97-100
1617799-0	1992	Differential effects of arginine on growth hormone releasing hormone and insulin induced growth hormone secretion.	Arginine	24-32	growth hormone releasing hormone	Homo sapiens	36-68
1617799-0	1992	Differential effects of arginine on growth hormone releasing hormone and insulin induced growth hormone secretion.	Arginine	24-32	insulin	Homo sapiens	73-80
1617799-0	1992	Differential effects of arginine on growth hormone releasing hormone and insulin induced growth hormone secretion.	Arginine	24-32	growth hormone 1	Homo sapiens	36-50
1355713-1	1992	L-365,260 [3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-N"-(3-methylphenylurea)], a potent nonpeptide antagonist of the CCKB receptor, is currently under investigation to treat anxiety and panic disorders.	Arginine	0-2	cholecystokinin B receptor	Rattus norvegicus	149-162
1617799-5	1992	RESULTS: Arginine increased GH responses to GHRH and decreased GH responses to hypoglycaemia, but this inhibitory effect of arginine was reversed by GHRH.	Arginine	9-17	growth hormone releasing hormone	Homo sapiens	44-48
1617799-5	1992	RESULTS: Arginine increased GH responses to GHRH and decreased GH responses to hypoglycaemia, but this inhibitory effect of arginine was reversed by GHRH.	Arginine	124-132	growth hormone releasing hormone	Homo sapiens	149-153
1569192-0	1992	Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency.	Arginine	11-14	serpin family A member 1	Homo sapiens	27-46
1569192-4	1992	A G to T transition at nucleotide 10038 results in the substitution of Met to an Arg, converting alpha 1-AT into an Arg-Ser protease inhibitor (serpin) that inhibited thrombin and Factor Xa more effectively than antithrombin III.	Arginine	81-84	serpin family A member 1	Homo sapiens	97-107
1569192-4	1992	A G to T transition at nucleotide 10038 results in the substitution of Met to an Arg, converting alpha 1-AT into an Arg-Ser protease inhibitor (serpin) that inhibited thrombin and Factor Xa more effectively than antithrombin III.	Arginine	81-84	coagulation factor II, thrombin	Homo sapiens	167-175
1507480-3	1992	The first instance demonstrated a G----C transversion at codon 365 from GGA (Gly) to CGA (Arg), which was seen in three individuals of the two families.	Arginine	90-93	chromogranin A	Homo sapiens	85-88
1588839-2	1992	Arginine (ARG) has been demonstrated to potentiate the GHRH-induced GH increase in normal subjects, likely acting via inhibition of hypothalamic somatostatin release.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	55-59
1588839-2	1992	Arginine (ARG) has been demonstrated to potentiate the GHRH-induced GH increase in normal subjects, likely acting via inhibition of hypothalamic somatostatin release.	Arginine	0-8	growth hormone 1	Homo sapiens	55-57
1588839-2	1992	Arginine (ARG) has been demonstrated to potentiate the GHRH-induced GH increase in normal subjects, likely acting via inhibition of hypothalamic somatostatin release.	Arginine	10-13	growth hormone releasing hormone	Homo sapiens	55-59
1588839-2	1992	Arginine (ARG) has been demonstrated to potentiate the GHRH-induced GH increase in normal subjects, likely acting via inhibition of hypothalamic somatostatin release.	Arginine	10-13	growth hormone 1	Homo sapiens	55-57
1588839-3	1992	To shed further light onto the mechanisms underlying the blunted GH secretion in obesity, we studied the effect of ARG (0.5 g/kg infused intravenously [IV] over 30 minutes) on both basal and GHRH (1 micron/kg IV)-stimulated GH secretion.	Arginine	115-118	growth hormone releasing hormone	Homo sapiens	191-195
1588839-3	1992	To shed further light onto the mechanisms underlying the blunted GH secretion in obesity, we studied the effect of ARG (0.5 g/kg infused intravenously [IV] over 30 minutes) on both basal and GHRH (1 micron/kg IV)-stimulated GH secretion.	Arginine	115-118	growth hormone 1	Homo sapiens	191-193
1588839-5	1992	In obese subjects, the GH response to both GHRH and ARG was lower (P less than .01 and P less than .002, respectively) than in controls.	Arginine	52-55	growth hormone 1	Homo sapiens	23-25
1588839-6	1992	ARG potentiated the GH response to GHRH in obese patients (P less than .0003).	Arginine	0-3	growth hormone 1	Homo sapiens	20-22
1588839-6	1992	ARG potentiated the GH response to GHRH in obese patients (P less than .0003).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	35-39
1588839-7	1992	However, in these patients, the GH secretion elicited by GHRH, even when coadministered with ARG, persisted at reduced levels (P less than .005) when compared with controls.	Arginine	93-96	growth hormone 1	Homo sapiens	32-34
1588839-7	1992	However, in these patients, the GH secretion elicited by GHRH, even when coadministered with ARG, persisted at reduced levels (P less than .005) when compared with controls.	Arginine	93-96	growth hormone releasing hormone	Homo sapiens	57-61
1588839-9	1992	In conclusion, ARG enhances the blunted GHRH-induced GH increase in obese patients, but the GH responses to ARG alone and to ARG + GHRH persist at lower levels than in normals.	Arginine	15-18	growth hormone releasing hormone	Homo sapiens	40-44
1588839-9	1992	In conclusion, ARG enhances the blunted GHRH-induced GH increase in obese patients, but the GH responses to ARG alone and to ARG + GHRH persist at lower levels than in normals.	Arginine	15-18	growth hormone 1	Homo sapiens	40-42
1588839-9	1992	In conclusion, ARG enhances the blunted GHRH-induced GH increase in obese patients, but the GH responses to ARG alone and to ARG + GHRH persist at lower levels than in normals.	Arginine	15-18	growth hormone 1	Homo sapiens	53-55
1566853-2	1992	Field stimulation of gastric muscle strips was accompanied by frequency-dependent relaxation, vasoactive intestinal peptide (VIP) release, and NO production: the NO synthase inhibitor, NG-nitro-L-arginine (L-NNA) completely inhibited NO production and partly inhibited VIP release (52-54%) and relaxation (58-88%); inhibition of all three functions was reversed by L-arginine but not by D-arginine.	Arginine	194-204	vasoactive intestinal peptide	Homo sapiens	269-272
1559227-6	1992	The p53 mutations in cell lines included a codon 248 C to T transition (arginine to tryptophan) in RD and a codon 280 A to T transversion (arginine to serine) in RH30.	Arginine	72-80	tumor protein p53	Homo sapiens	4-7
1559227-6	1992	The p53 mutations in cell lines included a codon 248 C to T transition (arginine to tryptophan) in RD and a codon 280 A to T transversion (arginine to serine) in RH30.	Arginine	139-147	tumor protein p53	Homo sapiens	4-7
1621986-4	1992	The utility of this resin was tested by the synthesis of a biotinylated peptide, Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg-biocytin-NH2, for use as an in vitro substrate for myristoyl-CoA:protein N-myristoyltransferase (NMT), the enzyme that catalyzes protein N-myristoylation.	Arginine	105-108	N-myristoyltransferase 1	Homo sapiens	186-208
1621986-4	1992	The utility of this resin was tested by the synthesis of a biotinylated peptide, Gly-Asn-Ala-Ala-Ala-Ala-Arg-Arg-biocytin-NH2, for use as an in vitro substrate for myristoyl-CoA:protein N-myristoyltransferase (NMT), the enzyme that catalyzes protein N-myristoylation.	Arginine	105-108	N-myristoyltransferase 1	Homo sapiens	210-213
1560020-4	1992	Excellent electron density could be traced for the decapeptide, beginning with Asp-7f and ending with Arg-16f in the active site of thrombin; the remaining 4 residues, which have been cleaved from the tetradecapeptide at the Arg-16f/Gly-17f bond, are not seen.	Arginine	102-105	coagulation factor II, thrombin	Homo sapiens	132-140
1566853-3	1992	In isolated gastric muscle cells, VIP caused relaxation and stimulated NO production: L-NNA completely inhibited NO production and partly inhibited relaxation; the inhibition was reversed by L-arginine but not by D-arginine.	Arginine	191-201	vasoactive intestinal peptide	Homo sapiens	34-37
1349567-4	1992	Five were detected as loss of a natural or introduced TaqI site at codons -5, 583, 1941, 2116, and 2209 and were confirmed as CGA (Arg) to TGA (Stop) nonsense mutations by DNA sequencing.	Arginine	131-134	chromogranin A	Homo sapiens	126-129
1637918-2	1992	Analysis of such complexes revealed that one apo-A-1 molecule binds 17-22, whereas one apo-E molecule--30-35 sterol molecules, which approximately correspondence to the amount of arginine residues in these proteins.	Arginine	179-187	apolipoprotein E	Homo sapiens	87-92
1516765-2	1992	Arginine stimulation was administered as a 150 mg/kg bolus followed by 10 mg.kg-1.min-1 to six subjects with high insulin response and to seven subjects with low insulin response.	Arginine	0-8	insulin	Homo sapiens	114-121
1516765-2	1992	Arginine stimulation was administered as a 150 mg/kg bolus followed by 10 mg.kg-1.min-1 to six subjects with high insulin response and to seven subjects with low insulin response.	Arginine	0-8	insulin	Homo sapiens	162-169
1516765-3	1992	Before dexamethasone treatment the incremental insulin level during 0-10 min of arginine was higher in subjects with high (36.5 +/- 6.8 microU/ml) than in subjects with low response (14.5 +/- 2.3 microU/ml), p less than 0.01 for difference.	Arginine	80-88	insulin	Homo sapiens	47-54
1516765-4	1992	Dexamethasone treatment (6 mg/day for 60 h) markedly enhanced the insulin response to arginine in subjects with high response (+99% 0-30 min) but failed to affect the subjects with low response (+4% 0-30 min).	Arginine	86-94	insulin	Homo sapiens	66-73
1516765-6	1992	Decreased responsiveness to arginine in subjects with low insulin response, especially during dexamethasone treatment, suggests a Beta-cell capacity defect although a decreased potentiating-sensing effect of glucose cannot be completely ruled out.	Arginine	28-36	insulin	Homo sapiens	58-65
1349567-8	1992	Upon sequencing, this codon contained a novel missense mutation, a C-to-G transversion changing CGA (Arg 1696) to GGA (Gly).	Arginine	101-104	chromogranin A	Homo sapiens	96-99
1372338-4	1992	Three of these polypeptides--54, 93, and 125 kDa--were biologically active in promoting cell attachment and were recognized by monoclonal antibodies that bind fibronectin near the arg-gly-asp (RGD) domain.	Arginine	180-183	fibronectin 1	Homo sapiens	159-170
1350374-0	1992	Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets.	Arginine	18-26	somatostatin	Rattus norvegicus	35-47
1549103-4	1992	A new dominant mutation of p53, resulting in the change of a cysteine to an arginine at amino acid residue 141, was identified.	Arginine	76-84	tumor protein p53	Homo sapiens	27-30
1304352-3	1992	In the presence of Ca2+, yeast calmodulin is sequentially cleaved at arginine 126, then lysine 115, and finally at lysine 77.	Arginine	69-77	calmodulin	Saccharomyces cerevisiae S288C	31-41
1350374-4	1992	In our hands arginine stimulated somatostatin secretion only in the presence of insulin antiserum.	Arginine	13-21	somatostatin	Rattus norvegicus	33-45
1350374-7	1992	In conclusion, glucagon apparently represents the central mediator of arginine effects on somatostatin secretion in isolated rat pancreatic islets in batch stimulation experiments.	Arginine	70-78	somatostatin	Rattus norvegicus	90-102
1544488-3	1992	These results indicate that matrix assembly of fibronectin requires both regions and can proceed in the absence of the type III repeats including the one containing the cell adhesive Arg-Gly-Asp sequence.	Arginine	183-186	fibronectin 1	Homo sapiens	47-58
1547220-3	1992	Activated protein C inactivates thrombin-activated FVIII through cleavage adjacent to position Arg 336 in the cofactor.	Arginine	95-98	coagulation factor II, thrombin	Homo sapiens	32-40
1312861-8	1992	Injection of L-[guanidineimino-15N2]arginine combined with Fe(2+)-citrate or LPS led to the formation of the EPR signal of NO-FeDETC2 characterized by a doublet HFS at g perpendicular, demonstrating that the NO originates from the guanidino nitrogens of L-arginine in vivo.	Arginine	254-264	toll-like receptor 4	Mus musculus	77-80
1372827-1	1992	NO synthase (NOS; EC 1.14.23) catalyzes the conversion of L-arginine into L-citrulline and a guanylyl cyclase-activating factor (GAF) that is chemically identical with nitric oxide or a nitric oxide-releasing compound (NO).	Arginine	58-68	fibroblast growth factor 9	Rattus norvegicus	129-132
1541823-0	1992	Growth inhibition of Francisella tularensis live vaccine strain by IFN-gamma-activated macrophages is mediated by reactive nitrogen intermediates derived from L-arginine metabolism.	Arginine	159-169	interferon gamma	Mus musculus	67-76
1541823-6	1992	Because reactive nitrogen intermediates derived from L-arginine metabolism have been implicated in the killing of various infectious organisms, we evaluated the possibility that such a mechanism might contribute to the antitularemic activity of IFN-gamma-stimulated macrophages.	Arginine	53-63	interferon gamma	Mus musculus	245-254
1547237-11	1992	The apparent preference for a gauche- (chi 1 = +60) side-chain conformation of Ile(59) in the bound state may be explained by the existence of a positively charged arginine residue among the hydrophobic residues in the thrombin exosite.	Arginine	164-172	coagulation factor II, thrombin	Homo sapiens	219-227
1628160-11	1992	The data indicate that NO generated de novo from L-arginine mediates a significant component of the vasodilator effect of endothelin-1 in the anaesthetized, ganglion-blocked SH rat.	Arginine	49-59	endothelin 1	Rattus norvegicus	122-134
1531768-5	1992	Receptor-binding activity was studied for mutants (Asp-93)-, (Leu-93)- and des-(Arg-98)interleukin 1 beta"s.	Arginine	80-83	interleukin 1 beta	Homo sapiens	87-105
1541289-14	1992	From the amino acid compositions, it appears that all six proteins are rich in arginine, cysteine and histidine and are closely related to pmP2 and mP2.	Arginine	79-87	proline rich protein HaeIII subfamily 1	Mus musculus	140-143
1541289-16	1992	The C-terminal part of protamine mP2 starting at arginine 15 is common to all proteins as assessed by amino acid compositions and peptide maps.	Arginine	49-57	proline rich protein HaeIII subfamily 1	Mus musculus	33-36
1541678-0	1992	Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.	Arginine	60-70	interleukin 2	Homo sapiens	93-106
1541678-1	1992	An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents.	Arginine	129-139	interferon gamma	Homo sapiens	3-19
1541678-8	1992	Our results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.	Arginine	156-166	interleukin 2	Homo sapiens	81-85
1312118-2	1992	BSC40 cells lack a processing endoprotease of the neuropeptide precursor, pro-opiomelanocortin (POMC), which possesses multiple cleavage sites at pairs of basic residues, Lys-Arg and Arg-Arg, a motif similar to that found in the cleavage site of the F0 proteins.	Arginine	175-178	proopiomelanocortin	Homo sapiens	96-100
1740503-4	1992	One allele, from his mother, contains a stop codon (TGA) in place of arginine (CGA) at amino acid position 239 in exon 4.	Arginine	69-77	chromogranin A	Homo sapiens	79-82
1740484-5	1992	Screening of amplified DNA from normal subjects and patients with FIH revealed two single base changes that altered migration of amplified preproPTH gene fragments through denaturing gels: 1) an A----G transition in intron 1; 10 nucleotides upstream of exon 2; and 2) a C----A transversion in exon 3 that conserves the arginine residue at codon 52 (CGA----AGA).	Arginine	319-327	parathyroid hormone	Homo sapiens	139-148
1312118-2	1992	BSC40 cells lack a processing endoprotease of the neuropeptide precursor, pro-opiomelanocortin (POMC), which possesses multiple cleavage sites at pairs of basic residues, Lys-Arg and Arg-Arg, a motif similar to that found in the cleavage site of the F0 proteins.	Arginine	183-186	proopiomelanocortin	Homo sapiens	96-100
1312118-2	1992	BSC40 cells lack a processing endoprotease of the neuropeptide precursor, pro-opiomelanocortin (POMC), which possesses multiple cleavage sites at pairs of basic residues, Lys-Arg and Arg-Arg, a motif similar to that found in the cleavage site of the F0 proteins.	Arginine	183-186	proopiomelanocortin	Homo sapiens	96-100
1531861-6	1992	In parallel, arginine-stimulated insulin release was inhibited by IL-1 beta exposure (166 +/- 31 pg/islet/h, mean +/- SE, n = 3) in comparison to control islets (1,679 +/- 307).	Arginine	13-21	interleukin 1 beta	Rattus norvegicus	66-75
1347312-7	1992	The effects of 1B6 alone and the synergistic effects of 1B6 and IFN-gamma or sTNF and IFN-gamma are arginine dependent.	Arginine	100-108	interferon gamma	Mus musculus	64-73
1347312-7	1992	The effects of 1B6 alone and the synergistic effects of 1B6 and IFN-gamma or sTNF and IFN-gamma are arginine dependent.	Arginine	100-108	interferon gamma	Mus musculus	86-95
1371917-1	1992	Murine macrophages activated by interferon-gamma and lipopolysaccharide become leishmanicidal through a process involving L-arginine-derived nitrogen oxidation products.	Arginine	122-132	interferon gamma	Mus musculus	32-48
1581642-1	1992	The N-terminal fragment Met-Ala-Ala-Arg-Leu-Leu-Arg-Val-Ala-Ser-Ala-Ala-Leu-Gly (PA1-14) of the adrenodoxin precursor was previously found to inhibit the import of the precursor into mitochondria.	Arginine	36-39	PAXIP1 associated glutamate rich protein 1	Homo sapiens	81-87
1737795-0	1992	Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis.	Arginine	30-33	von Willebrand factor	Homo sapiens	69-90
1732004-9	1992	These results illustrate the importance of Arg 53 of the mature vWF subunit for the binding of FVIII to vWF, and identify an amino acid residue within a disulfide loop not previously known to be involved in this interaction.	Arginine	43-46	von Willebrand factor	Homo sapiens	64-67
1371193-0	1992	Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.	Arginine	52-62	insulin	Homo sapiens	0-7
1371193-1	1992	L-arginine causes insulin release from pancreatic B cells.	Arginine	0-10	insulin	Homo sapiens	18-25
1371193-2	1992	Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide.	Arginine	58-68	insulin	Homo sapiens	107-114
1371193-2	1992	Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide.	Arginine	137-147	insulin	Homo sapiens	107-114
1371193-4	1992	NG-substituted L-arginine analogs inhibited the release of both insulin and NO.	Arginine	15-25	insulin	Homo sapiens	64-78
1310709-3	1992	Macrophages exposed to A23187 or IFN-gamma in the presence of LPS and FCS secreted significant amounts of PGE2 independently of the presence of L-arginine in the incubation medium.	Arginine	144-154	interferon gamma	Homo sapiens	33-42
1543013-0	1992	GH response to GHRH, insulin, clonidine and arginine after GHRH pretreatment in children.	Arginine	44-52	growth hormone releasing hormone	Homo sapiens	59-63
1543013-4	1992	Moreover, comparing the GH peak values following the second stimulus, it appears that the greatest GH responses were elicited by GHRH (1.31 +/- 0.23 nmol/l) and clonidine (1.11 +/- 0.22 nmol/l), while the lowest was elicited by arginine (0.43 +/- 0.04 nmol/l).	Arginine	228-236	growth hormone releasing hormone	Homo sapiens	129-133
1632851-2	1992	FDB is caused by a G to A mutation at nucleotide 10 708 in exon 26 of the apo B gene creating a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	126-134	apolipoprotein B	Homo sapiens	74-79
1531588-6	1992	During digestion of fibrinogen at low plasmin concentration, up to 65% of the FpA was cleaved just subsequent to the progressive release of B beta-(1-42)-peptide, and the Arg-16-Gly-17 bond of the A alpha-chain became relatively stable towards plasmin action when present in fragment E (and possibly fragment Y).	Arginine	171-174	fibrinogen beta chain	Homo sapiens	20-30
1732004-9	1992	These results illustrate the importance of Arg 53 of the mature vWF subunit for the binding of FVIII to vWF, and identify an amino acid residue within a disulfide loop not previously known to be involved in this interaction.	Arginine	43-46	von Willebrand factor	Homo sapiens	104-107
1737852-7	1992	The other two nonhereditary p53 mutations included a T to G transversion at codon 270 (phenylalanine to cysteine) and a G to C transversion at codon 248 (arginine to proline).	Arginine	154-162	tumor protein p53	Homo sapiens	28-31
1285651-4	1992	Among them C5a or its degradation product C5a des Arg seems to be the most important mediator because it exerts a potent chemotactic effect on inflammatory cells.	Arginine	50-53	complement C5a receptor 1	Homo sapiens	11-14
1729374-0	1992	IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.	Arginine	18-28	tumor necrosis factor	Mus musculus	124-151
1281611-1	1992	A human urine serine proteinase chymotrypsin like hydrolyzes the peptide bonds: Phe-Ser (kinin); Gly-Gly, Leu-Arg, Phe-Lys (neuropeptides) and Gln-Gln (substance P).	Arginine	110-113	tachykinin precursor 1	Homo sapiens	152-163
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	fibrinogen beta chain	Homo sapiens	203-213
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	fibrinogen beta chain	Homo sapiens	215-217
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	von Willebrand factor	Homo sapiens	220-241
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	von Willebrand factor	Homo sapiens	243-246
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	thrombospondin 1	Homo sapiens	249-263
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	thrombospondin 1	Homo sapiens	265-268
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	fibronectin 1	Homo sapiens	271-282
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	fibronectin 1	Homo sapiens	284-286
1370885-5	1992	Porcine vWF lacks four contiguous residues in the first segment and has two positively charged arginine residues in the second.	Arginine	95-103	von Willebrand factor	Homo sapiens	8-11
1285651-4	1992	Among them C5a or its degradation product C5a des Arg seems to be the most important mediator because it exerts a potent chemotactic effect on inflammatory cells.	Arginine	50-53	complement C5a receptor 1	Homo sapiens	42-45
1371492-4	1992	We used the peptide Trp-Thr-Val-Pro-Thr-Ala, WTVPTA (deduced from the complementary nucleotide sequence to that which codes for the Arg-Gly-Asp, RGD, domain in fibronectin), to test the immunologic activity of ITP sera.	Arginine	132-135	fibronectin 1	Homo sapiens	160-171
1600334-2	1992	FDB is caused by a G to A mutation at nucleotide 10,708 in exon 26 of the apo B gene creating a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	126-134	apolipoprotein B	Homo sapiens	74-79
1307747-3	1992	The aim of our study was to evaluate the effects of arginine on the GH-releasing hormone (GHRH)-stimulated GH secretion in patients with hyperthyroidism.	Arginine	52-60	growth hormone releasing hormone	Homo sapiens	68-88
1729223-5	1992	The route of catabolic entry of arginine into the cell, the general amino acid permease (GAP1), is sensitive to NCR.	Arginine	32-40	amino acid permease GAP1	Saccharomyces cerevisiae S288C	89-93
1729196-5	1992	An immobilized preparation of the enzyme cleaved glycophorin A at several positions, with a major site of cleavage at Arg-31-Asp-32.	Arginine	118-121	glycophorin A (MNS blood group)	Homo sapiens	49-62
1732513-4	1992	Of the charged amino acids in the C"" and D strands of the amino-terminal domain of CD4, alteration of only two, lysine 46 and arginine 59, dramatically disrupted ability to bind gp120.	Arginine	127-135	CD4 molecule	Homo sapiens	84-87
1728638-5	1992	Pre-treatment of cells with 25-250 micrograms/ml of synthetic peptides containing the fibronectin cell-recognition sequence RGD (Arg-Gly-Asp) resulted in a concentration-dependent inhibition of fibronectin-mediated chemotaxis, whereas chemotaxis to collagen was not affected.	Arginine	129-132	fibronectin 1	Homo sapiens	86-97
1282939-1	1992	The effect of the arginine analogue, N omega-nitro-L-arginine (L-NNA) was studied on bradykinin-induced relaxation in porcine coronary arteries.	Arginine	18-26	kininogen 1	Homo sapiens	85-95
1728638-5	1992	Pre-treatment of cells with 25-250 micrograms/ml of synthetic peptides containing the fibronectin cell-recognition sequence RGD (Arg-Gly-Asp) resulted in a concentration-dependent inhibition of fibronectin-mediated chemotaxis, whereas chemotaxis to collagen was not affected.	Arginine	129-132	fibronectin 1	Homo sapiens	194-205
1738296-5	1992	The present data suggest that vascular smooth muscle relaxation induced by ET-1 and ET-3 is mainly ascribed to synthesis and release of nitric oxide from L-arginine in endothelium.	Arginine	154-164	endothelin 1	Homo sapiens	75-88
1480105-0	1992	Identification of two arginine residues involved in the binding of substrate to neutral endopeptidase 24-11.	Arginine	22-30	membrane metalloendopeptidase	Homo sapiens	80-107
1371576-0	1992	Interactions of galanin and arginine on growth hormone, prolactin, and insulin secretion in man.	Arginine	28-36	growth hormone 1	Homo sapiens	40-54
1560730-1	1992	Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline.	Arginine	127-137	interferon gamma	Homo sapiens	46-62
1560730-1	1992	Macrophages and other host cells activated by interferon-gamma (IFN-gamma) can be induced to form a flavoprotein that converts L-arginine to nitric oxide+L-citrulline.	Arginine	127-137	interferon gamma	Homo sapiens	64-73
1371576-3	1992	We studied the effect of GAL (80 pmol/kg/min infused over 60 minutes) on the arginine- (ARG, 30 g infused over 30 minutes) stimulated GH, PRL, insulin, and C-peptide secretion in eight healthy volunteers (age, 20 to 30 years).	Arginine	77-85	growth hormone 1	Homo sapiens	134-136
1387746-0	1992	[The effect of arginine on hydrolysis of fibrinogen by plasmin and mini-plasmin].	Arginine	15-23	fibrinogen beta chain	Homo sapiens	41-51
1371576-5	1992	GAL enhanced the ARG-induced stimulation of both GH (1,634.1 +/- 293.1 v 566.9 +/- 144.0 micrograms/L/h, P less than .02) and PRL secretion (1,541.9 +/- 248.8 v 1,023.8 +/- 158.7 micrograms/L/h, P less than .02).	Arginine	17-20	growth hormone 1	Homo sapiens	49-51
1371576-6	1992	On the contrary, GAL blunted the ARG-stimulated insulin (816.3 +/- 87.7 v 1,322.7 +/- 240.9 mU/L/h, P less than .05), as well as C-peptide secretion (105.1 +/- 9.8 v 132.8 +/- 17.3 micrograms/L/h, P less than .02).	Arginine	33-36	insulin	Homo sapiens	48-55
1371576-9	1992	In conclusion, these results show that in man GAL potentiates the GH response to ARG, suggesting that these drugs act at the hypothalamic level, at least in part, via different mechanisms.	Arginine	81-84	growth hormone 1	Homo sapiens	66-68
1523102-11	1992	Two patients with a moderate form of the disease demonstrated an abnormal electrophoretic pattern in exon 8 and sequencing demonstrated missense mutations at codon 372 for arginine within a thrombin activation site.	Arginine	172-180	coagulation factor II, thrombin	Homo sapiens	190-198
1732722-2	1992	The 46-amino acid "pro" domain is removed by a renin-processing enzyme, to produce enzymatically active renin, by cleavage at an Arg-Leu bond.	Arginine	129-132	renin	Homo sapiens	47-52
1732722-2	1992	The 46-amino acid "pro" domain is removed by a renin-processing enzyme, to produce enzymatically active renin, by cleavage at an Arg-Leu bond.	Arginine	129-132	renin	Homo sapiens	104-109
1387746-1	1992	The rate of plasmin or Val442-plasmin catalyzed hydrolysis of fibrinogen decreases several times as affected by arginine in high concentrations.	Arginine	112-120	fibrinogen beta chain	Homo sapiens	62-72
1837145-6	1991	These seven amino acids (Arg-4, Leu-6, Phe-46, Ile-56, Lys-93, Lys-103, and Glu-105) are clustered in the IL-1 beta molecule, forming a discontinuous binding site.	Arginine	25-28	interleukin 1 beta	Homo sapiens	106-115
1764092-1	1991	Poly(ADP-ribose)polymerase (PADPRP) was found to be an efficient protein acceptor for the arginine-specific ADP-ribosylation reaction catalyzed by cholera toxin (CT).	Arginine	90-98	poly(ADP-ribose) polymerase 1	Homo sapiens	0-26
1764092-1	1991	Poly(ADP-ribose)polymerase (PADPRP) was found to be an efficient protein acceptor for the arginine-specific ADP-ribosylation reaction catalyzed by cholera toxin (CT).	Arginine	90-98	poly(ADP-ribose) polymerase 1	Homo sapiens	28-34
1764092-7	1991	Our results are consistent with the conclusion that PADPRP is susceptible to arginine-specific mono(ADP-ribosyl)ation catalyzed by CT.	Arginine	77-85	poly(ADP-ribose) polymerase 1	Homo sapiens	52-58
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Arginine	130-133	interferon gamma	Homo sapiens	28-37
1837236-5	1991	The stoichiometry of this modification revealed that a single arginine in either IL-1 alpha or IL-1 beta is responsible for the loss of activity.	Arginine	62-70	interleukin 1 beta	Homo sapiens	95-104
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 beta	Homo sapiens	67-76
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 beta	Homo sapiens	176-185
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 beta	Homo sapiens	67-76
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 beta	Homo sapiens	176-185
1944469-7	1991	In two of the patients, histidine was substituted for arginine at position 201 of Gs alpha, and in the other two patients cysteine was substituted for the same arginine residue.	Arginine	54-62	GNAS complex locus	Homo sapiens	82-90
1757093-3	1991	We have analysed 38 patients for mutations in exon 4 of the NF1 gene, and found one patient with a C----T transition at base position 1087 of the cDNA, changing an arginine codon to a stop codon, at amino acid position 365.	Arginine	164-172	neurofibromin 1	Homo sapiens	60-63
1744095-14	1991	Arginine is uniquely able to make the multiple contacts found in the ABP sugar site, and we conclude that this residue plays a similar role in sugar binding for lactose repressor protein.	Arginine	0-8	sex hormone binding globulin	Homo sapiens	69-72
1661096-0	1991	Platelet inhibition by an L-arginine-derived substance released by IL-1 beta-treated vascular smooth muscle cells.	Arginine	26-36	interleukin 1 beta	Rattus norvegicus	67-76
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Arginine	130-133	fibronectin 1	Homo sapiens	29-31
1961117-0	1991	Age-related decrease in plasma growth hormone: response to growth hormone-releasing hormone, arginine, and L-dopa in obesity.	Arginine	93-101	growth hormone 1	Homo sapiens	31-45
1816326-3	1991	This latter effect appears related to increased exposure of arginine- and lysine-rich segments of apoB-100.	Arginine	60-68	apolipoprotein B	Homo sapiens	98-106
1961117-5	1991	The mean peak levels of plasma GH in response to GRH, arginine, and L-dopa in obese subjects were 11.3 +/- 2.1, 21.9 +/- 4.4, and 5.2 +/- 0.3 ng/mL in adolescents, 8.2 +/- 1.6, 9.1 +/- 1.5, and 3.1 +/- 0.6 ng/mL in those in their 20s, and 4.5 +/- 0.4, 7.3 +/- 1.4, and 2.8 +/- 0.3 ng/mL in those 30 years or older, respectively, showing a significant decrease in peak GH level with advancing age (P less than .05 to P less than .01).	Arginine	54-62	growth hormone 1	Homo sapiens	31-33
1657959-3	1991	Evidence is presented which suggests that IL-1 beta-induced inhibition of insulin secretion is dependent on the metabolism of L-arginine to nitric oxide.	Arginine	126-136	interleukin 1 beta	Homo sapiens	42-51
1657998-3	1991	We have used site-directed mutagenesis of the Saccharomyces cerevisiae Rieske iron-sulfur protein gene (RIP 1) to convert cysteines 159, 164, 178, and 180 to serines, and to convert histidines 161 and 181 to arginines.	Arginine	208-217	ubiquinol--cytochrome-c reductase catalytic subunit RIP1	Saccharomyces cerevisiae S288C	104-109
1939180-0	1991	The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences.	Arginine	121-124	insulin	Homo sapiens	24-34
1935971-0	1991	Interferon-gamma/lipopolysaccharide-treated mouse embryonic fibroblasts are killed by a glycolysis/L-arginine-dependent process accompanied by depression of mitochondrial respiration.	Arginine	101-109	interferon gamma	Mus musculus	0-16
1935971-11	1991	Withdrawal of L-arginine from the culture medium prevented cell death in IFN-gamma/LPS-treated MEF.	Arginine	14-24	interferon gamma	Mus musculus	73-82
1935971-11	1991	Withdrawal of L-arginine from the culture medium prevented cell death in IFN-gamma/LPS-treated MEF.	Arginine	14-24	toll-like receptor 4	Mus musculus	83-86
1939180-0	1991	The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences.	Arginine	125-128	insulin	Homo sapiens	24-34
1939180-0	1991	The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences.	Arginine	125-128	insulin	Homo sapiens	24-34
1939180-2	1991	Similar Ca2(+)-dependent proteases are also present in pancreatic secretory granules and cleave proinsulin at two sites, Arg-Arg and Lys-Arg.	Arginine	121-124	insulin	Homo sapiens	96-106
1939180-2	1991	Similar Ca2(+)-dependent proteases are also present in pancreatic secretory granules and cleave proinsulin at two sites, Arg-Arg and Lys-Arg.	Arginine	125-128	insulin	Homo sapiens	96-106
1939180-2	1991	Similar Ca2(+)-dependent proteases are also present in pancreatic secretory granules and cleave proinsulin at two sites, Arg-Arg and Lys-Arg.	Arginine	125-128	insulin	Homo sapiens	96-106
1769438-3	1991	By infusing high dose insulin during arginine infusion, the previously exaggerated glucagon response to arginine could be normalized.	Arginine	37-45	insulin	Homo sapiens	22-29
1722124-1	1991	Chemical derivatization by phenylglyoxal (PGX) was applied to the identification of arginine in the neuropeptides dynorphin A (1-6) and substance P. The obtained products were separated on a short reversed phase C18 column and analysed on-line with the photodiode array UV technique.	Arginine	84-92	Bardet-Biedl syndrome 9	Homo sapiens	212-215
1939157-2	1991	Two forms of MGP were isolated from demineralization and urea extracts of bovine cortical bone, one 79 residues in length with the COOH terminus Phe-Arg-Gln and the other 83 residues in length with the COOH terminus Phe-Arg-Gln-Arg-Arg-Gly-Ala.	Arginine	149-152	matrix Gla protein	Bos taurus	13-16
1939157-2	1991	Two forms of MGP were isolated from demineralization and urea extracts of bovine cortical bone, one 79 residues in length with the COOH terminus Phe-Arg-Gln and the other 83 residues in length with the COOH terminus Phe-Arg-Gln-Arg-Arg-Gly-Ala.	Arginine	220-223	matrix Gla protein	Bos taurus	13-16
1939157-2	1991	Two forms of MGP were isolated from demineralization and urea extracts of bovine cortical bone, one 79 residues in length with the COOH terminus Phe-Arg-Gln and the other 83 residues in length with the COOH terminus Phe-Arg-Gln-Arg-Arg-Gly-Ala.	Arginine	220-223	matrix Gla protein	Bos taurus	13-16
1659388-1	1991	Cytochrome c binds ATP with marked specificity at a site that contains the evolutionarily invariant residue Arg-91.	Arginine	108-111	cytochrome c, somatic	Homo sapiens	0-12
1769438-0	1991	Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic alpha cells.	Arginine	30-38	insulin	Homo sapiens	75-82
1769438-3	1991	By infusing high dose insulin during arginine infusion, the previously exaggerated glucagon response to arginine could be normalized.	Arginine	104-112	insulin	Homo sapiens	22-29
1769438-2	1991	This study was designed to determine whether the glucagon hyperresponsiveness to arginine in these patients would improve by insulin infused at a high enough dose to overcome insulin resistance.	Arginine	81-89	insulin	Homo sapiens	125-132
1769438-4	1991	To normalize the abnormal glucagon response, insulin doses of 4.2 +/- 0.7 and 3.8 +/- 0.5 IU were required during arginine infusion in obese hyperinsulinaemic patients with impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetes mellitus, respectively.	Arginine	114-122	insulin	Homo sapiens	45-52
1769438-9	1991	These results clearly demonstrate that, similar to non-obese hypoinsulinaemic Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients, the exaggerated Alpha-cell response to arginine infusion in obese hyperinsulinaemic patients with glucose intolerance is secondary to the reduction of insulin action on the pancreatic Alpha cell, and that the expression of insulin action plays an important part in normalizing these abnormalities.	Arginine	198-206	insulin	Homo sapiens	86-93
1818184-1	1991	Lipopolysaccharide plus interferon gamma stimulated the L-arginine-.NO pathway of murine, but not human pulmonary alveolar macrophages.	Arginine	56-66	interferon gamma	Mus musculus	24-40
1919006-4	1991	MC cytotoxicity against the TNF alpha-sensitive target, WEHI-164, was potentiated by L-arginine.	Arginine	85-95	tumor necrosis factor	Rattus norvegicus	28-37
1655979-6	1991	The results of studies of the formal potential of dopamine in the presence of Arg and Arg-containing peptides confirmed that catechol protons are directly involved in the association and that the chemical species of dopamine associated with neurotensin is a catecholate form.	Arginine	78-81	neurotensin	Homo sapiens	241-252
1655979-6	1991	The results of studies of the formal potential of dopamine in the presence of Arg and Arg-containing peptides confirmed that catechol protons are directly involved in the association and that the chemical species of dopamine associated with neurotensin is a catecholate form.	Arginine	86-89	neurotensin	Homo sapiens	241-252
1787825-1	1991	Amylin is a proteinaceous hormone secreted form insulin-producing pancreatic beta-cells following stimulation by food molecules such as glucose and arginine.	Arginine	148-156	insulin	Homo sapiens	48-55
1667689-6	1991	The major form of Anolis alpha-MSH is nonacetylated and has the following novel primary sequence: Ser-Tyr-Ala-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro(Val-amide).	Arginine	126-129	alpha-msh	Anolis carolinensis	25-34
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	11-14	fibronectin 1	Homo sapiens	154-165
1798746-2	1991	Its minimal concentration required to obtain the maximum inhibition of C5a des Arg (1 x 10(-8) M) chemotactic activity is 2.5 x 10(-8) M. Bioactivity of this substance was maintained for 2 weeks, stored in a dark room at room temperature under aerobic conditions.	Arginine	79-82	complement C5a receptor 1	Homo sapiens	71-74
1659403-2	1991	Furthermore, substitution of glutamine for arginine in putative transmembrane segment M2 of the GluR2 subunit makes the heteromeric channels permeable to Ca2+.	Arginine	43-51	glutamate receptor, ionotropic, AMPA 2 S homeolog	Xenopus laevis	96-101
1659406-0	1991	Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells.	Arginine	29-39	kininogen 1	Homo sapiens	0-10
1659406-2	1991	In the presence of nitro-L-arginine (100 microM), an inhibitor of NO synthase, the stimulatory effect of bradykinin on L-arginine uptake was partially inhibited while NO release was completely abolished.	Arginine	25-35	kininogen 1	Homo sapiens	105-115
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	11-14	fibrinogen beta chain	Homo sapiens	191-201
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	11-14	fibronectin 1	Homo sapiens	203-214
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	11-14	von Willebrand factor	Homo sapiens	216-237
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	69-72	fibronectin 1	Homo sapiens	154-165
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	69-72	fibrinogen beta chain	Homo sapiens	191-201
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	69-72	fibronectin 1	Homo sapiens	203-214
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	69-72	von Willebrand factor	Homo sapiens	216-237
1720019-1	1991	Characterization of a side-product obtained during the synthesis of Arg-Glu-Asp-Val (REDV) with inhibitory activity in thrombin-activated platelet aggregation was carried out.	Arginine	68-71	coagulation factor II, thrombin	Homo sapiens	119-127
1657140-7	1991	The amino acid sequence accounting for 42% of rabbit paraoxonase was determined by (1) gas-phase sequencing of the intact protein and (2) peptide fragments from lysine and arginine digests.	Arginine	172-180	paraoxonase 1	Homo sapiens	53-64
1918993-2	1991	The recently described L-arginine-dependent nitric oxide (NO) pathway has been proposed to interact synergistically with the TNF pathway in murine macrophage-mediated tumor cytotoxicity in vitro.	Arginine	23-33	tumor necrosis factor	Mus musculus	125-128
1947552-3	1991	Stimulated insulin levels following arginine (MANOVA, p less than 0.001), and secretin (MANOVA, p less than 0.001) were 1.5 to 3 fold elevated compared to controls.	Arginine	36-44	insulin	Homo sapiens	11-18
1947552-4	1991	In contrast, integrated C-peptide responses following stimulation with arginine or secretin did not differ significantly between the two groups.	Arginine	71-79	insulin	Homo sapiens	24-33
1840561-0	1991	Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa.	Arginine	8-11	rhodopsin	Homo sapiens	28-37
1930142-12	1991	However, for the present substrates the additional interaction of the carboxylate group with a protein residue (probably an arginine residue) provides further stabilization for the adducts HRP-D-tyrosine and LPO-L-tyrosine with respect to the corresponding complexes with the opposite enantiomers.	Arginine	124-132	lactoperoxidase	Homo sapiens	208-211
1680583-5	1991	Using apo B-100 as an example we located on different chromosomes the defect in codon 3500 and a mutation in codon 3611, which produces another Arg----Gln change in the encoded apo B-100 amino acid sequence, in two probands heterozygous for both mutations.	Arginine	144-147	apolipoprotein B	Homo sapiens	6-15
1680583-5	1991	Using apo B-100 as an example we located on different chromosomes the defect in codon 3500 and a mutation in codon 3611, which produces another Arg----Gln change in the encoded apo B-100 amino acid sequence, in two probands heterozygous for both mutations.	Arginine	144-147	apolipoprotein B	Homo sapiens	177-186
1935933-1	1991	Structural and dynamic properties of [8-arginine]vasopressin and a class of highly potent vasopressin V1 antagonists which contain 3-mercapto-3,3-cyclopentamethylene propionic acid (Mca) in position 1 of the vasopressin sequence have been determined.	Arginine	40-48	arginine vasopressin	Homo sapiens	49-60
1918016-2	1991	It has been reported that the sequence Tyr20-X-Arg-Phe23 present within the cytoplasmic tail of the transferrin receptor may represent a tyrosine internalization signal (Collawn, J.F., Stangel, M., Kuhn, L.A., Esekogwu, V., Jing, S., Trowbridge, I.S., and Tainer, J.	Arginine	47-50	transferrin	Homo sapiens	100-111
1915557-9	1991	Phagocytosis also increased M phi NO2- production elicited by IFN-gamma plus TNF-alpha in L-arginine-deficient media.	Arginine	90-100	tumor necrosis factor	Mus musculus	77-86
1778986-5	1991	pETB-40P with a deletion of one Cys residue and four Arg residues in the N-terminal part was a better substrate than the other two for FXa or trypsin in the production of big ET-1.	Arginine	53-56	endothelin 1	Homo sapiens	175-179
1797705-1	1991	The N-terminal heptadecapeptide of human angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-Glu-Ser-Thr-NH2 ), with the C-terminal carboxyl group amidated, was synthesized in order to study the role of Asn-Glu-Ser, a putative carbohydrate binding site, on the hydrolysis by human renin.	Arginine	62-65	angiotensinogen	Homo sapiens	41-56
1665906-5	1991	Ideas of the interaction of the C5a receptor with its ligand were derived mainly from the search for accommodation of the functionally essential arginine residues 40 and 74 of C5a.	Arginine	145-153	complement C5a receptor 1	Homo sapiens	32-44
1920361-1	1991	The development of potent antithrombotic agents from the fibrinogen platelet receptor binding sequences Fg-alpha 572-575 -Arg-Gly-Asp-Ser- and Fg-gamma 400-411 -HHLGGAKQAGDV, believed to be a cryptic RGD-type sequence, is described.	Arginine	122-125	fibrinogen beta chain	Homo sapiens	57-67
1665906-5	1991	Ideas of the interaction of the C5a receptor with its ligand were derived mainly from the search for accommodation of the functionally essential arginine residues 40 and 74 of C5a.	Arginine	145-153	complement C5a receptor 1	Homo sapiens	32-35
1716370-4	1991	Unlike peptides related to Arg-Gly-Asp-Ser and His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val that bind to the fibrinogen receptor, this peptide binds to fibrinogen.	Arginine	27-30	fibrinogen beta chain	Homo sapiens	112-122
1801307-6	1991	DRB1*13.MW typed serologically as DRw13 and was identical to DRB1*1301 except at codon 71 where AGG encodes arginine instead of GAG encoding glutamic acid.	Arginine	108-116	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
1776135-3	1991	Arginine-406 is located at the 12th amino acid residue from the reactive site on the C-terminal side of AT-III in a core region of the molecule which has been highly conserved during evolution of serine protease inhibitor (serpin) family.	Arginine	0-8	coagulation factor II, thrombin	Homo sapiens	196-211
1746000-9	1991	Altogether, our results indicate that thrombin recognition sites for hirudin 54-65 and platelet membrane glycoprotein Ib share common structures located near the beta cleavage site at Arg 73 on the thrombin B chain.	Arginine	184-187	coagulation factor II, thrombin	Homo sapiens	38-46
1746000-9	1991	Altogether, our results indicate that thrombin recognition sites for hirudin 54-65 and platelet membrane glycoprotein Ib share common structures located near the beta cleavage site at Arg 73 on the thrombin B chain.	Arginine	184-187	coagulation factor II, thrombin	Homo sapiens	198-206
1793052-3	1991	When Arg in position 4 of DuP118 was replaced by Glu (Glu-4), proteoglycan-synthesis-inhibitory activity was reduced to 20% and proteoglycan-degrading activity to 2% of that induced by native IL-1 beta.	Arginine	5-8	interleukin 1 beta	Mus musculus	192-201
1955097-0	1991	Acute insulin response to intravenous glucose, glucagon and arginine in some subjects at risk for type 1 (insulin-dependent) diabetes mellitus.	Arginine	60-68	insulin	Homo sapiens	6-13
1680314-0	1991	Oxidation of the active site of glutamine synthetase: conversion of arginine-344 to gamma-glutamyl semialdehyde.	Arginine	68-76	glutamate-ammonia ligase	Homo sapiens	32-52
1955097-6	1991	In contrast, Group IIb demonstrated lower insulin responses to both glucagon and arginine than control subjects (p less than 0.007 and p less than 0.04 respectively) or than "normo-responders" to glucose (p less than 0.007 and p less than 0.04 respectively).	Arginine	81-89	insulin	Homo sapiens	42-49
1955097-7	1991	In Group IIb however, arginine-stimulated insulin release was increased compared to the response to glucose (p less than 0.006), while glucagon and glucose led to non-statistically different responses.	Arginine	22-30	insulin	Homo sapiens	42-49
1937565-7	1991	One site on the Fn molecule known to interact with phagocytic cells is the cell-binding domain containing the Arg-Gly-Asp (RGD) sequence.	Arginine	110-113	fibronectin 1	Homo sapiens	16-18
1840568-3	1991	One novel point mutation was however found in a moderately severe haemophiliac; a CGA (Arg) to CTA (Leu) transversion at codon 2209, an evolutionarily conserved residue in the C2 domain of the factor VIII protein.	Arginine	87-90	chromogranin A	Homo sapiens	82-85
1944815-0	1991	Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	67-99
1714914-4	1991	Amino-terminal amino acid microsequencing of CE9 immunoaffinity purified from epididymis suggested that the cleavage occurred on the carboxy-terminal side of arginine-74 in the primary sequence of CE9, resulting in the loss of approximately 40% of the amino acids in the extra-cellular domain of this transmembrane glycoprotein.	Arginine	158-166	basigin (Ok blood group)	Rattus norvegicus	45-48
1714914-4	1991	Amino-terminal amino acid microsequencing of CE9 immunoaffinity purified from epididymis suggested that the cleavage occurred on the carboxy-terminal side of arginine-74 in the primary sequence of CE9, resulting in the loss of approximately 40% of the amino acids in the extra-cellular domain of this transmembrane glycoprotein.	Arginine	158-166	basigin (Ok blood group)	Rattus norvegicus	197-200
1716636-1	1991	Site-directed mutagenesis studies have suggested that additional peptide information in the central cell-binding domain of fibronectin besides the minimal Arg-Gly-Asp (RGD) sequence is required for its full adhesive activity.	Arginine	155-158	fibronectin 1	Homo sapiens	123-134
1885770-7	1991	A three-base deletion was identified of nucleotides 1821-1823 in the cDNA which predicted the removal of an arginine residue from position 608 of the acid sphingomyelinase polypeptide (delta R608).	Arginine	108-116	sphingomyelin phosphodiesterase 1	Homo sapiens	150-171
1944815-7	1991	When every GHRH bolus was combined with arginine a marked potentiation of GH response to both boluses was found.	Arginine	40-48	growth hormone 1	Homo sapiens	11-13
1944815-9	1991	In conclusion, our results show that arginine potentiates the GHRH-induced GH secretion preventing the lessening of somatotrope responsiveness to the neurohormone alone.	Arginine	37-45	growth hormone releasing hormone	Homo sapiens	62-66
1944815-9	1991	In conclusion, our results show that arginine potentiates the GHRH-induced GH secretion preventing the lessening of somatotrope responsiveness to the neurohormone alone.	Arginine	37-45	growth hormone 1	Homo sapiens	62-64
1802238-3	1991	Analytical data of the degradation products showed that, in the case of AVP and [Sar7]AVP, there were two major sites of cleavage: Tyr-Phe and Arg-Gly.	Arginine	143-146	arginine vasopressin	Rattus norvegicus	72-75
1802238-3	1991	Analytical data of the degradation products showed that, in the case of AVP and [Sar7]AVP, there were two major sites of cleavage: Tyr-Phe and Arg-Gly.	Arginine	143-146	arginine vasopressin	Rattus norvegicus	86-89
1883381-6	1991	ARAP contains 10 cysteines and 30 basic amino acids (23 lysines and 7 arginines).	Arginine	70-79	midkine	Homo sapiens	0-4
1868092-15	1991	Further mechanistic proposals are made for Arg-127, whose probable role in binding substrates is apparent in these CPA-phosphonate complexes.	Arginine	43-46	carboxypeptidase A1	Homo sapiens	115-118
1874726-3	1991	Analysis of canavanine-containing lysozyme purified from these insects reveals that 21% of the arginine residues are replaced by canavanine; this residue substitution results in a loss of 49.5% of the catalytic activity.	Arginine	95-103	lysozyme	Bombyx mori	34-42
1874726-6	1991	In contrast, replacement of 17% of the arginine in H. cecropia lysozyme by canavanine fails to affect the catalytic activity.	Arginine	39-47	lysozyme	Bombyx mori	63-71
1874726-8	1991	M. sexta lysozyme has an arginine at positions 23, 42, and 107.	Arginine	25-33	lysozyme	Bombyx mori	9-17
1874726-10	1991	The ability of incorporated canavanine to inhibit M. sexta lysozyme activity selectively may result from the fact that replacement of any one of the 3 arginine residues at position 23, 42, or 107 by canavanine causes the loss of catalytic activity.	Arginine	151-159	lysozyme	Bombyx mori	59-67
1874740-1	1991	Previous studies of adhesion mediated by the central cell-binding domain of fibronectin suggest that additional polypeptide information besides the Arg-Gly-Asp sequence is required for full activity.	Arginine	148-151	fibronectin 1	Homo sapiens	76-87
1872870-5	1991	A similar blunting effect of L-Arg on the fMLP (10(-7)M)-induced [Ca2+]i transient was detected.	Arginine	29-34	formyl peptide receptor 1	Homo sapiens	42-46
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Arginine	77-80	plasminogen activator, tissue type	Homo sapiens	172-205
1908232-1	1991	We have shown that synthetic peptides containing the amino acid sequence Asn-Arg-Arg-Leu, derived from the amino acid sequence of the inner loop of the kringle-2 domain of tissue-type plasminogen activator (tPA), inhibited complex formation between two chain tPA and plasminogen activator inhibitor-1 (PAI-1) by binding to PAI-1.	Arginine	77-80	plasminogen activator, tissue type	Homo sapiens	207-210
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	86-89	plasminogen activator, tissue type	Homo sapiens	241-244
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	90-93	plasminogen activator, tissue type	Homo sapiens	241-244
1907272-0	1991	A highly conserved sequence of the Arg-Gly-Asp-binding domain of the integrin beta 3 subunit is sensitive to stimulation.	Arginine	35-38	integrin subunit beta 3	Homo sapiens	69-84
1907272-1	1991	The Arg-Gly-Asp (RGD)-binding domain of GPIIb-IIIa has been localized in a fragment of the GPIIIa subunit that includes the sequence between amino acids 109 and 171.	Arginine	4-7	integrin subunit beta 3	Homo sapiens	91-97
1768762-1	1991	A congenital fibrinogen variant in a German family is described which has been identified as a substitution of His in position 16 of the A alpha-chain for Arg, manifested over three generations in heterozygous form.	Arginine	155-158	fibrinogen beta chain	Homo sapiens	13-23
1936696-0	1991	First peak insulin release after intravenous glucose and arginine is maintained for up to 3 years after segmental pancreas transplantation.	Arginine	57-65	insulin	Homo sapiens	11-18
1936696-1	1991	In this study we have investigated blood glucose and serum free insulin response to glucose and to arginine orally or intravenously, 3 months and 3 years after a successful segmental, neoprene-injected, pancreas transplantation.	Arginine	99-107	insulin	Homo sapiens	64-71
1793440-3	1991	We have screened for two different mutations; firstly a mutation in the apolipoprotein B (apo B) gene that results in the substitution of glutamine (Gln) for arginine (Arg) at amino acid residue 3500 (apo B3500 mutation).	Arginine	158-166	apolipoprotein B	Homo sapiens	72-88
1793440-3	1991	We have screened for two different mutations; firstly a mutation in the apolipoprotein B (apo B) gene that results in the substitution of glutamine (Gln) for arginine (Arg) at amino acid residue 3500 (apo B3500 mutation).	Arginine	158-166	apolipoprotein B	Homo sapiens	90-95
1793440-3	1991	We have screened for two different mutations; firstly a mutation in the apolipoprotein B (apo B) gene that results in the substitution of glutamine (Gln) for arginine (Arg) at amino acid residue 3500 (apo B3500 mutation).	Arginine	168-171	apolipoprotein B	Homo sapiens	72-88
1793440-3	1991	We have screened for two different mutations; firstly a mutation in the apolipoprotein B (apo B) gene that results in the substitution of glutamine (Gln) for arginine (Arg) at amino acid residue 3500 (apo B3500 mutation).	Arginine	168-171	apolipoprotein B	Homo sapiens	90-95
1783488-0	1991	Aminopeptidase resistant Arg-Gly-Asp analogs are stable in plasma and inhibit platelet aggregation.	Arginine	25-28	carboxypeptidase Q	Homo sapiens	0-14
1872870-6	1991	The L-Arg antagonist, NG-monomethyl-L-arginine (L-NMMA), reverted the L-Arg blocking effect on both ET- and fMLP-induced [Ca2+]i transients.	Arginine	4-9	formyl peptide receptor 1	Homo sapiens	108-112
1872870-6	1991	The L-Arg antagonist, NG-monomethyl-L-arginine (L-NMMA), reverted the L-Arg blocking effect on both ET- and fMLP-induced [Ca2+]i transients.	Arginine	70-75	formyl peptide receptor 1	Homo sapiens	108-112
1770316-13	1991	The first base of the Arg codon (CGA) at residue 412 in exon 10 was replaced by a T, resulting in a termination codon (TGA).	Arginine	22-25	chromogranin A	Homo sapiens	33-36
1712820-8	1991	The C5a-induced vasopermeability was markedly enhanced in animals that had been previously treated with an inhibitor of serum carboxypeptidase, which converts C5a to the less potent derivative, C5a des Arg.	Arginine	202-205	hemolytic complement	Mus musculus	4-7
1713692-6	1991	Mutants of CD4 expressing amino acids with distinct physicochemical properties at positions Arg-54, Ala-55, Asp-56, and Ser-57 in V1, the first extracellular immunoglobulin-like domain, have been generated and studied qualitatively and quantitatively for interaction with HLA class II antigens, for membrane expression, for the integrity of CD4 epitopes recognized by a panel of monoclonal antibodies, and for gp120 binding.	Arginine	92-95	CD4 molecule	Homo sapiens	11-14
1717877-3	1991	The D-enantiomer of residues 2, 4, 5, 6, 7, 8, 10 and 11 was introduced in the sequence of Substance P: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH1.	Arginine	104-107	tachykinin precursor 1	Homo sapiens	91-102
1858031-4	1991	In (+)arginine culture the KC TNF-alpha production peaked early before decreasing as PGE2 production increased.	Arginine	6-14	tumor necrosis factor	Homo sapiens	30-39
1858031-5	1991	In (-)arginine culture, however, KC TNF-alpha production was significantly (p less than 0.01) reduced, whereas PGE2 production was amplified (p less than 0.01).	Arginine	6-14	tumor necrosis factor	Homo sapiens	36-45
1858031-6	1991	When cyclooxygenase blockade with indomethacin completely prevented KC production of PGE2 in (-)arginine culture, TNF-alpha production was upregulated (p less than 0.001 vs (-)arginine; p not significant vs (+)arginine).	Arginine	176-184	tumor necrosis factor	Homo sapiens	114-123
1858031-6	1991	When cyclooxygenase blockade with indomethacin completely prevented KC production of PGE2 in (-)arginine culture, TNF-alpha production was upregulated (p less than 0.001 vs (-)arginine; p not significant vs (+)arginine).	Arginine	96-104	tumor necrosis factor	Homo sapiens	114-123
1858031-6	1991	When cyclooxygenase blockade with indomethacin completely prevented KC production of PGE2 in (-)arginine culture, TNF-alpha production was upregulated (p less than 0.001 vs (-)arginine; p not significant vs (+)arginine).	Arginine	176-184	tumor necrosis factor	Homo sapiens	114-123
1891701-6	1991	Amino acid analysis of this fragment indicated that the arginine residue, located at the physiological thrombin cleavage site, was replaced by cysteine.	Arginine	56-64	coagulation factor II, thrombin	Homo sapiens	103-111
1858031-7	1991	These arginine-specific depression of TNF-alpha responses appeared unique to KC because both TNF-alpha and PGE2 levels increased when peritoneal, pleural, and alveolar macrophages were stimulated by lipopolysaccharide in (-)arginine medium.	Arginine	6-14	tumor necrosis factor	Homo sapiens	38-47
1858031-7	1991	These arginine-specific depression of TNF-alpha responses appeared unique to KC because both TNF-alpha and PGE2 levels increased when peritoneal, pleural, and alveolar macrophages were stimulated by lipopolysaccharide in (-)arginine medium.	Arginine	6-14	tumor necrosis factor	Homo sapiens	93-102
1858031-7	1991	These arginine-specific depression of TNF-alpha responses appeared unique to KC because both TNF-alpha and PGE2 levels increased when peritoneal, pleural, and alveolar macrophages were stimulated by lipopolysaccharide in (-)arginine medium.	Arginine	224-232	tumor necrosis factor	Homo sapiens	38-47
1648965-7	1991	From an inspection of the ferric transferrin crystal structure, the most likely anion binding residues in the cleft are Arg-632 and Lys-534 in the C-terminal lobe and Lys-206 and Lys-296 in the N-terminal lobe.	Arginine	120-123	transferrin	Homo sapiens	33-44
1712676-11	1991	The activity for forming L-citrulline and nitrite/nitrate from L-arginine was markedly induced by treatment with either LPS alone or LPS + IFN-gamma but not with IFN-gamma.	Arginine	63-73	interferon gamma	Mus musculus	139-148
1712676-11	1991	The activity for forming L-citrulline and nitrite/nitrate from L-arginine was markedly induced by treatment with either LPS alone or LPS + IFN-gamma but not with IFN-gamma.	Arginine	63-73	interferon gamma	Mus musculus	162-171
1712676-0	1991	L-arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma.	Arginine	0-10	interferon gamma	Mus musculus	117-133
2055204-3	1991	We have studied the processing of a C-peptide-deleted precursor of neuropeptide Y (NPY) in which the precursor terminates in the sequence Gly-Lys-Arg and does not require any dibasic specific endoproteolytic processing.	Arginine	146-149	pro-neuropeptide Y	Cricetulus griseus	67-81
1905642-9	1991	Consistent with the conclusion that endogenously produced TNF-alpha accounts for the synergism of IL 4 with IFN-gamma is the finding that N omega-monomethyl-L-arginine, an inhibitor of the L-arginine-dependent generation of microbicidal nitrogen intermediates, totally blocked the M phi activation induced by IFN-gamma combined with IL 4 as well as by IFN-gamma combined with TNF-alpha.	Arginine	157-167	tumor necrosis factor	Mus musculus	58-67
1905642-9	1991	Consistent with the conclusion that endogenously produced TNF-alpha accounts for the synergism of IL 4 with IFN-gamma is the finding that N omega-monomethyl-L-arginine, an inhibitor of the L-arginine-dependent generation of microbicidal nitrogen intermediates, totally blocked the M phi activation induced by IFN-gamma combined with IL 4 as well as by IFN-gamma combined with TNF-alpha.	Arginine	157-167	tumor necrosis factor	Mus musculus	376-385
2055204-3	1991	We have studied the processing of a C-peptide-deleted precursor of neuropeptide Y (NPY) in which the precursor terminates in the sequence Gly-Lys-Arg and does not require any dibasic specific endoproteolytic processing.	Arginine	146-149	pro-neuropeptide Y	Cricetulus griseus	83-86
1938100-3	1991	Substitution of the Arg residue occupying position 2 of [Sar1,Ile8]ANG II (pA2 8.1) by Gly, Ala, Nle, Phe, Pro or Sar reduced the antagonist potency to pA2 = 7.0, 6.8, 6.7, 6.8, 5.8 and 5.3, respectively.	Arginine	20-23	angiotensinogen	Rattus norvegicus	67-73
2045466-3	1991	Carbohydrate metabolism was characterized using the modified iv glucose tolerance test (minimal model), the acute insulin responses to arginine during a 3-step glycemic clamp, and the oral glucose tolerance test.	Arginine	135-143	insulin	Homo sapiens	114-121
1874449-3	1991	The cytoplasmic domain of cTR contains the motif Tyr-Xaa-Arg-Phe (YXRF) that is the recognition signal for high-efficiency endocytosis of hTR.	Arginine	57-60	calcitonin receptor	Homo sapiens	26-29
2051232-2	1991	At a dose of 5.4 mmol/kg body weight, arginine, cysteine, histidine and the amino acid mixture were equipotent in terms of increasing plasma GIP and insulin concentrations.	Arginine	38-46	gastric inhibitory polypeptide	Mus musculus	141-144
1874449-3	1991	The cytoplasmic domain of cTR contains the motif Tyr-Xaa-Arg-Phe (YXRF) that is the recognition signal for high-efficiency endocytosis of hTR.	Arginine	57-60	telomerase RNA component	Homo sapiens	138-141
1750211-0	1991	[Regulation of by arginine of cytochrome p-450 activity and lipid peroxidation in rat liver and testicular tissue during hypoxia].	Arginine	18-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	30-46
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	245-248	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	288-291
2059196-2	1991	These inhibitors, "hirulogs", retain the carboxy terminal Hir53-64 domain that interacts with the anion binding exosite of thrombin, connected via an oligoglycyl spacer unit to a catalytic site-directed moiety modeled on the sequence [D]Phe-Pro-Arg-X.	Arginine	245-248	coagulation factor II, thrombin	Homo sapiens	123-131
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	311-314	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	288-291
1673992-13	1991	Additional adhesion assays performed in the presence of a pentapeptide containing the amino acid sequence arg-gly-asp (RGD), which is part of one of the cell-binding domains of FN, demonstrated that the RGD-containing peptide almost totally blocked the phorbol ester-induced adhesion of U937 cells to FN.	Arginine	106-109	fibronectin 1	Homo sapiens	177-179
1674745-6	1991	A C to T mutation converted arginine (CGT) at position 145 of the mature protein to cysteine (TGT) thus creating the apoE-2 variant.	Arginine	28-36	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	94-97
1674745-6	1991	A C to T mutation converted arginine (CGT) at position 145 of the mature protein to cysteine (TGT) thus creating the apoE-2 variant.	Arginine	28-36	apolipoprotein E	Homo sapiens	117-123
1369319-1	1991	We have found a novel adhesion receptor on the human endothelial cell for the peptide sequence Arg-Glu-Asp-Val (REDV), which is present in the III-CS domain of human plasma fibronectin, with a dissociation constant of 2.2 x 10(-6) M and 5.8 x 10(6) sites/cell.	Arginine	95-98	fibronectin 1	Homo sapiens	173-184
1649126-7	1991	Of the mediators tested, guinea-pig C5a des Arg in zymosan-activated plasma was the most active.	Arginine	44-47	complement C5a receptor 1	Homo sapiens	36-39
1649126-9	1991	C5a des Arg in maximally activated plasma induced a 1500% increase in eosinophil accumulation, while rHC5a (10(-10) mol dose) induced a 600% increase.	Arginine	8-11	complement C5a receptor 1	Homo sapiens	0-3
2036431-5	1991	In addition, replacement of either arginine-107 in the second domain or glutamine-123 in the third domain with glutamic acid resulted in compounds that were 2 and 4 times more potent than bFGF.	Arginine	35-43	fibroblast growth factor 2	Homo sapiens	188-192
1892487-2	1991	It is postulated that this disorder results from a G to A mutation at nucleotide 10,708 in exon 26 of the apo B gene creating a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	158-166	apolipoprotein B	Homo sapiens	106-111
1674522-8	1991	Inasmuch as the 140-kDa fragment of TSP contains an Arg-Gly-Asp sequence similar to the cell recognition site of FN and VN, we determined whether RGDS peptides would inhibit PMN adhesion.	Arginine	52-55	thrombospondin 1	Homo sapiens	36-39
1902865-10	1991	We conclude that induction of inorganic nitrogen oxide synthesis from L-arginine by the synergistic combination of IFN gamma, TNF alpha, and LPS accounts for most of the biologic activity of CM, and that IFN gamma is the major priming factor.	Arginine	70-80	interferon gamma	Mus musculus	115-124
1902865-10	1991	We conclude that induction of inorganic nitrogen oxide synthesis from L-arginine by the synergistic combination of IFN gamma, TNF alpha, and LPS accounts for most of the biologic activity of CM, and that IFN gamma is the major priming factor.	Arginine	70-80	tumor necrosis factor	Mus musculus	126-135
1673992-13	1991	Additional adhesion assays performed in the presence of a pentapeptide containing the amino acid sequence arg-gly-asp (RGD), which is part of one of the cell-binding domains of FN, demonstrated that the RGD-containing peptide almost totally blocked the phorbol ester-induced adhesion of U937 cells to FN.	Arginine	106-109	fibronectin 1	Homo sapiens	301-303
1720827-5	1991	In this study, it is shown that a synthetic peptide, Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu, which corresponds to amino acid residues 4-14 of bovine myelin basic protein, is the most specific and convenient substrate for selective assay of protein kinase C among various phosphate acceptor proteins and peptides.	Arginine	61-64	myelin basic protein	Bos taurus	154-174
1720827-5	1991	In this study, it is shown that a synthetic peptide, Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu, which corresponds to amino acid residues 4-14 of bovine myelin basic protein, is the most specific and convenient substrate for selective assay of protein kinase C among various phosphate acceptor proteins and peptides.	Arginine	77-80	myelin basic protein	Bos taurus	154-174
1904084-1	1991	Macrophage production of arginine-derived NO2- provides a simple method for detection and quantitation of interferon-gamma (IFN-gamma) in murine cell culture fluids.	Arginine	25-33	interferon gamma	Mus musculus	106-122
1903394-1	1991	The assembly of fibronectin into disulfide cross-linked extracellular matrices requires the interaction of mesenchymal cells with two distinct sites on fibronectin, the Arg-Gly-Asp cell adhesive site and an amino-terminal site contained within the first five type I homologous repeats (Quade, B. J., and McDonald, J.	Arginine	169-172	fibronectin 1	Homo sapiens	16-27
1903394-1	1991	The assembly of fibronectin into disulfide cross-linked extracellular matrices requires the interaction of mesenchymal cells with two distinct sites on fibronectin, the Arg-Gly-Asp cell adhesive site and an amino-terminal site contained within the first five type I homologous repeats (Quade, B. J., and McDonald, J.	Arginine	169-172	fibronectin 1	Homo sapiens	152-163
1709810-6	1991	Therefore, the processing site of the alpha-fetoprotein signal peptide during maturation of the protein occurs at the N-terminal side of the arginine residue formerly indicated as residue-1.	Arginine	141-149	alpha fetoprotein	Homo sapiens	38-55
2052547-6	1991	The dissociation constants of Arg-38 and Phe-42 analogs for p70 were consistent with intermediate-affinity binding; the Kd values were not significantly affected by the presence of p55 in binding to the high-affinity IL-2 receptor complex.	Arginine	30-33	ubiquitin associated and SH3 domain containing B	Homo sapiens	60-63
1904084-1	1991	Macrophage production of arginine-derived NO2- provides a simple method for detection and quantitation of interferon-gamma (IFN-gamma) in murine cell culture fluids.	Arginine	25-33	interferon gamma	Mus musculus	124-133
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
2026586-5	1991	The N-terminal amino acid sequence, Arg-Ala-Pro-Lys-Glu-Val-Pro-Leu-, is different from the N-terminal sequence of any other cytochrome P-450s so far reported.	Arginine	36-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	125-141
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	65-78
1871720-8	1991	Both vWf binding and platelet adhesion to sulfatides can be inhibited by the sulfated polysaccharide dextran sulfate at low concentration, fucoidan at high concentrations, but not by heparin, fibrinogen, fibronectin, or the synthetic peptides Gly-Arg-Gly-Asp-Ser-Pro or Gly-Arg-Gly-Glu-Ser-Pro.	Arginine	247-250	von Willebrand factor	Homo sapiens	5-8
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
2018974-1	1991	Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) binds fibrinogen via recognition sequences such as Arg-Gly-Asp (RGD).	Arginine	99-102	fibrinogen beta chain	Homo sapiens	54-64
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	172-176
2069780-5	1991	We propose that bradykinin inhibits norepinephrine efflux by stimulating intraneuronal nitric oxide from arginine.	Arginine	105-113	kininogen 1	Canis lupus familiaris	16-26
2067318-3	1991	The defective binding results from a G to A mutation at amino acid 10,708 in exon 26 of the apolipoprotein B (apo B) gene creating a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	163-171	apolipoprotein B	Homo sapiens	92-108
2067318-3	1991	The defective binding results from a G to A mutation at amino acid 10,708 in exon 26 of the apolipoprotein B (apo B) gene creating a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	163-171	apolipoprotein B	Homo sapiens	110-115
2039451-6	1991	Ionization of the residue with a pKa of 5.46 has a strong effect on activity towards the substrate with an arginine in P2 (8.4-fold increase in activity) but has only a moderate effect on the rate of hydrolysis with Cbz-Cit-Arg-NH-Mec (2.3-fold increase in activity) and virtually no effect with Cbz-Phe-Arg-NH-Mec.	Arginine	107-115	C-C motif chemokine ligand 28	Homo sapiens	311-314
1706713-2	1991	The apparent Km (6.6 microM) and Vmax (99 nmol x min-1 x mg-1) observed with N omega-hydroxy-L-arginine were similar to those observed with L-arginine (Km = 2.3 microM; Vmax = 54 mumol x min-1 x mg-1).	Arginine	93-103	CD59 molecule (CD59 blood group)	Homo sapiens	49-54
1911530-7	1991	In the absence of IFN-gamma, TNF and LPS stimulate the conversion of arginine into ornithine but not citrulline.	Arginine	69-77	tumor necrosis factor	Mus musculus	29-32
1911530-8	1991	However, when TNF or LPS stimulated macrophages are simultaneously treated with IFN-gamma, ornithine production is relatively inhibited by the strong OAD reaction that competes with the ASE reaction for its substrate L-arginine.	Arginine	217-227	tumor necrosis factor	Mus musculus	14-17
1911530-8	1991	However, when TNF or LPS stimulated macrophages are simultaneously treated with IFN-gamma, ornithine production is relatively inhibited by the strong OAD reaction that competes with the ASE reaction for its substrate L-arginine.	Arginine	217-227	interferon gamma	Mus musculus	80-89
1680182-1	1991	Aminopeptidase activity associated with human buccal tissue and primary cultures of hamster buccal epithelium homogenates was assayed fluorometrically using 4-methoxy-2-naphthylamides of leucine, alanine, and arginine.	Arginine	209-217	carboxypeptidase Q	Homo sapiens	0-14
2023926-9	1991	Of interest, the Arg----Leu substitution occurred in one of the ASM alleles from the two Ashkenazi Jewish NPD type B patients studied and in none of the ASM alleles of 15 non-Jewish type B patients.	Arginine	17-20	sphingomyelin phosphodiesterase 1	Homo sapiens	64-67
2019570-4	1991	During the activation, factor XI was cleaved at a single Arg-Ile bond by thrombin or factor XIa to produce an amino-terminal 50-kDa heavy chain and a carboxyl-terminal 35-kDa light chain.	Arginine	57-60	coagulation factor II, thrombin	Homo sapiens	73-81
1709004-5	1991	as NG-methylarginine, indicating the high degree of specificity for the arginine residue as well as the myelin basic protein in the intact myelin membranes.	Arginine	12-20	myelin basic protein	Bos taurus	104-124
1709004-6	1991	The possibility of a charge alteration of myelin basic protein resulting from its arginine methylation was investigated by using the purified component 1 of myelin basic protein.	Arginine	82-90	myelin basic protein	Bos taurus	42-62
2018799-7	1991	Competitive binding experiments with agarose-bound heparin and soluble GAG also suggest that after formation of insoluble complexes with arterial CSPG and resolubilization the exposure of Lys, Arg-rich segments of apoB-100 is increased.	Arginine	193-196	apolipoprotein B	Homo sapiens	214-222
2039451-6	1991	Ionization of the residue with a pKa of 5.46 has a strong effect on activity towards the substrate with an arginine in P2 (8.4-fold increase in activity) but has only a moderate effect on the rate of hydrolysis with Cbz-Cit-Arg-NH-Mec (2.3-fold increase in activity) and virtually no effect with Cbz-Phe-Arg-NH-Mec.	Arginine	107-115	C-C motif chemokine ligand 28	Homo sapiens	231-234
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Arginine	353-361	interferon gamma	Mus musculus	97-113
1911530-3	1991	In view of the physiological importance of ornithine and putrescine, we now investigated whether interferon-gamma (IFN-gamma), a principal stimulator of the OAD activity, may lead to the accumulation of the deiminated derivative citrulline at the expense of ornithine production, or whether the carbon backbone could be reutilized for the production of arginine and ornithine.	Arginine	353-361	interferon gamma	Mus musculus	115-124
1853466-3	1991	Nitrogen bubbles activated human complement as measured by generation of the fluid-phase, complement-split product C5a des Arg.	Arginine	123-126	complement C5a receptor 1	Homo sapiens	115-118
1706713-2	1991	The apparent Km (6.6 microM) and Vmax (99 nmol x min-1 x mg-1) observed with N omega-hydroxy-L-arginine were similar to those observed with L-arginine (Km = 2.3 microM; Vmax = 54 mumol x min-1 x mg-1).	Arginine	93-103	CD59 molecule (CD59 blood group)	Homo sapiens	187-192
2008995-3	1991	Although C5a is rapidly degraded to the less potent chemotaxin C5a des Arg, binding of this peptide with its cochemotaxin Gcglobulin (GcG) can restore its chemotactic potency.	Arginine	71-74	complement C5a receptor 1	Homo sapiens	9-12
2008995-3	1991	Although C5a is rapidly degraded to the less potent chemotaxin C5a des Arg, binding of this peptide with its cochemotaxin Gcglobulin (GcG) can restore its chemotactic potency.	Arginine	71-74	complement C5a receptor 1	Homo sapiens	63-66
2008995-7	1991	In addition, we found that BALF enhanced C5a des Arg-mediated chemotaxis (48.3 +/- 5.6 versus 11.2 +/- 1.6 cells/high power field, p less than 0.05), an effect that was not seen in the presence of GcG antibody.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
2008995-8	1991	Furthermore, BALF GcG was similar to serum GcG using Western blot analysis, and the interaction of GcG with C5a des Arg was not inhibited by cigarette smoke.	Arginine	116-119	complement C5a receptor 1	Homo sapiens	108-111
2008995-9	1991	These data demonstrate that elevation of BALF GcG levels occurs in smoking-associated lung disease and that this protein is biologically active and capable of increasing C5a des Arg-mediated chemotaxis.	Arginine	178-181	complement C5a receptor 1	Homo sapiens	170-173
2043304-4	1991	The administration of L-arginine, a precursor of nitric oxide, prevented the inhibitory effect of LNMMA on the renal vasodilatory and excretory response to BK.	Arginine	22-32	kininogen 1	Canis lupus familiaris	156-158
1903761-0	1991	A serine-to-arginine (AGT-to-CGT) mutation in codon 549 of the CFTR gene in an Italian patient with severe cystic fibrosis.	Arginine	12-20	angiotensinogen	Homo sapiens	22-25
1903761-0	1991	A serine-to-arginine (AGT-to-CGT) mutation in codon 549 of the CFTR gene in an Italian patient with severe cystic fibrosis.	Arginine	12-20	CF transmembrane conductance regulator	Homo sapiens	63-67
2005387-3	1991	Cytotoxicity of M phi activated by IFN-gamma plus LPS was detected in the presence of about 0.1 mM or more of L-arginine.	Arginine	110-120	interferon gamma	Homo sapiens	35-44
1900875-11	1991	The biochemical target for TGF-beta suppressive activity in these reactions may be the pathway for nitric oxide production from L-arginine, because TGF-beta also inhibited the generation of nitric oxide by cytokine-activated macrophages.	Arginine	128-138	transforming growth factor beta 1	Homo sapiens	27-35
1900875-11	1991	The biochemical target for TGF-beta suppressive activity in these reactions may be the pathway for nitric oxide production from L-arginine, because TGF-beta also inhibited the generation of nitric oxide by cytokine-activated macrophages.	Arginine	128-138	transforming growth factor beta 1	Homo sapiens	148-156
1857535-2	1991	In the present study, a neurite promoting activity of thrombin inhibitors such as hirudin, D-Phe,Pro,Arg-CH2Cl, and paraamidinophenylalanine derivatives, was found in rat embryo (E17) septal neurons in primary culture.	Arginine	101-104	coagulation factor II	Rattus norvegicus	54-62
1999411-3	1991	We now show that of five pancreatic PLA-2 ("Group I" enzymes) tested from different species of mammals, the human enzyme that is most basic both globally (pI 8.7) and locally (Arg-6, Lys-7, and Lys-10) is active toward BPI-treated E. coli (approximately 1-2% activity of the most active Group II PLA-2) whereas the other four PLA-2 are essentially inactive (less than 0.1%).	Arginine	176-179	phospholipase A2 group IB	Homo sapiens	36-41
1999411-4	1991	The cDNA of the pig pancreatic PLA-2 (pI 6.4; Arg-6, Ser-7, Lys-10) has been modified by site-specific mutagenesis and the wild-type and mutant PLA-2 have been expressed in and purified from either E. coli or Saccharomyces cerevisiae to determine more precisely the structural determinants of PLA-2 activity toward BPI-treated E. coli.	Arginine	46-49	phospholipase A2, major isoenzyme	Sus scrofa	31-36
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Arginine	38-46	phospholipase A2, major isoenzyme	Sus scrofa	89-94
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Arginine	38-46	phospholipase A2 group IB	Homo sapiens	188-193
1706595-0	1991	Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which "buries" Ser-378, its site of phosphorylation by protein kinase A. Activation of blood platelets by thrombin was previously shown to specifically release protein kinase A, which in human plasma singles out and phosphorylates one protein, identified as vitronectin.	Arginine	27-30	coagulation factor II, thrombin	Homo sapiens	213-221
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Arginine	111-114	fibronectin 1	Homo sapiens	13-24
1671785-16	1991	When compared with the effects of dexamethasone on the GH response to arginine, the results with dopaminergic agents highlight important differences in the mechanisms of action of these indirectly acting GH secretagogues.	Arginine	70-78	growth hormone 1	Homo sapiens	55-57
1671785-16	1991	When compared with the effects of dexamethasone on the GH response to arginine, the results with dopaminergic agents highlight important differences in the mechanisms of action of these indirectly acting GH secretagogues.	Arginine	70-78	growth hormone 1	Homo sapiens	204-206
1826081-11	1991	These results demonstrate that the high-affinity 67 kDa laminin receptor previously identified in a range of normal and transformed cells and its complementary Tyr-Ile-Gly-Ser-Arg binding domain play an important role in the interaction of platelets with laminin.	Arginine	176-179	ribosomal protein SA	Homo sapiens	49-72
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Arginine	134-137	fibronectin 1	Homo sapiens	13-24
1825316-2	1991	125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro.	Arginine	134-137	fibronectin 1	Homo sapiens	13-24
1847464-10	1991	In this way we identified a functional nuclear localization signal, Leu-Lys-Arg-Pro-Arg-Ser-Pro-Ser-Ser, encompassing amino acids 379 to 386 of the EBNA-1 protein.	Arginine	76-79	EBNA-1	Human gammaherpesvirus 4	148-154
1847464-10	1991	In this way we identified a functional nuclear localization signal, Leu-Lys-Arg-Pro-Arg-Ser-Pro-Ser-Ser, encompassing amino acids 379 to 386 of the EBNA-1 protein.	Arginine	84-87	EBNA-1	Human gammaherpesvirus 4	148-154
1648717-2	1991	The lysine13 of a GRP-27 was substituted by arginine and lysine was added to the amino terminus.	Arginine	44-52	gastrin releasing peptide	Mus musculus	18-21
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	57-60	chorionic somatomammotropin hormone like 1	Homo sapiens	35-38
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	57-60	fibronectin 1	Homo sapiens	221-232
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	108-111	chorionic somatomammotropin hormone like 1	Homo sapiens	35-38
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	108-111	fibronectin 1	Homo sapiens	221-232
1671745-8	1991	On the other hand, catalase and/or H2O2 lead to a decrease in L-arginine-induced cyclic GMP formation.	Arginine	62-72	catalase	Mus musculus	19-27
1993649-4	1991	The mutation that disrupts binding is a Gln for Arg substitution of apoB-100 residue 3500.	Arginine	48-51	apolipoprotein B	Homo sapiens	68-76
1993172-3	1991	Analysis of the fibronectin domain in terms of its primary structure, its proposed organization into "type I modules", and its hydrophilic and flexible segments led to the identification of several arginine-containing sites of potential interaction with the sulfate groups of heparin.	Arginine	198-206	fibronectin 1	Homo sapiens	16-27
2004016-0	1991	The priming effects of the products of stimulated mononuclear cells on the response of neutrophils to C5a des arg.	Arginine	110-113	complement C5a receptor 1	Homo sapiens	102-105
2004016-10	1991	This suggests that TNF-alpha is the important cytokine upregulating PMN responses to other physiological mediators, including C5a des arg during the early phases of an inflammatory reaction.	Arginine	134-137	tumor necrosis factor	Homo sapiens	19-28
2004016-10	1991	This suggests that TNF-alpha is the important cytokine upregulating PMN responses to other physiological mediators, including C5a des arg during the early phases of an inflammatory reaction.	Arginine	134-137	complement C5a receptor 1	Homo sapiens	126-129
1713785-0	1991	Direct evidence for methylation of arginine residues in high molecular weight forms of basic fibroblast growth factor.	Arginine	35-43	fibroblast growth factor 2	Cavia porcellus	87-117
1999338-1	1991	We describe a simple method for characterizing a frequent polymorphism (that substitutes an arginine for a proline) in the coding sequence of the Tp53 gene in patients with colonic cancer and in a control population.	Arginine	92-100	tumor protein p53	Homo sapiens	146-150
1713785-5	1991	In this report we demonstrate that the higher molecular weight, amino terminally extended forms of bFGF contain methylated arginine residues.	Arginine	123-131	fibroblast growth factor 2	Cavia porcellus	99-103
1991651-6	1991	Addition of L-arginine to arginine-deficient but not arginine-containing endothelial cells rapidly restored the capacity of shear stress and bradykinin to generate EDRF.	Arginine	12-22	kininogen 1	Homo sapiens	141-151
1991651-6	1991	Addition of L-arginine to arginine-deficient but not arginine-containing endothelial cells rapidly restored the capacity of shear stress and bradykinin to generate EDRF.	Arginine	14-22	kininogen 1	Homo sapiens	141-151
1991651-6	1991	Addition of L-arginine to arginine-deficient but not arginine-containing endothelial cells rapidly restored the capacity of shear stress and bradykinin to generate EDRF.	Arginine	26-34	kininogen 1	Homo sapiens	141-151
1991827-6	1991	The gel filtration analysis showed that arginine stimulated the secretion of pancreatic glucagon (PG 33-61), major proglucagon fragment (PG 72-158) and probably GLP-1 (PG 72-107 amide) in both groups, whereas oral glucose stimulated the secretion of glicentin (PG 1-69) and intestinal GLP-1 (PG 78-107 amide), an insulinotropic hormone.	Arginine	40-48	glucagon	Homo sapiens	161-166
1991827-6	1991	The gel filtration analysis showed that arginine stimulated the secretion of pancreatic glucagon (PG 33-61), major proglucagon fragment (PG 72-158) and probably GLP-1 (PG 72-107 amide) in both groups, whereas oral glucose stimulated the secretion of glicentin (PG 1-69) and intestinal GLP-1 (PG 78-107 amide), an insulinotropic hormone.	Arginine	40-48	glucagon	Homo sapiens	285-290
2023299-6	1991	Their basal GH levels were normal with significantly reduced GH response to arginine provocation.	Arginine	76-84	growth hormone 1	Homo sapiens	61-63
1988776-5	1991	An index of insulin secretion in all four tests was obtained from measurement of the acute release of insulin in response to two intravenous (IV) boluses of arginine, one given basally and the other given after raising glucose levels to approximately 150 mg/dL above the baseline.	Arginine	157-165	insulin	Homo sapiens	12-19
1988776-9	1991	These results suggest that the diurnal insulin response to stimulation with arginine during a hyperglycemic clamp persists despite complete suppression of hGH by anticholinergic blockade, and that the diurnal insulin secretion is not caused by sleep- or meal-induced GH secretion.	Arginine	76-84	insulin	Homo sapiens	39-46
2065012-5	1991	Immediately at the site at which arginine binds there is one of only four RNA triplets in 92 group I RNA sequences: AGA/G and CGA/G.	Arginine	33-41	chromogranin A	Homo sapiens	126-129
1900240-8	1991	Evidence is presented that the synergistic action of IL 4 and IFN-gamma occurs via an L-arginine-dependent killing pathway.	Arginine	86-96	interferon gamma	Mus musculus	62-71
1915111-0	1991	Growth hormone (GH) profiles with successive provocation by GH-releasing hormone and arginine in children: a clinical appraisal.	Arginine	85-93	growth hormone 1	Homo sapiens	0-14
1915111-0	1991	Growth hormone (GH) profiles with successive provocation by GH-releasing hormone and arginine in children: a clinical appraisal.	Arginine	85-93	growth hormone 1	Homo sapiens	16-18
1703296-5	1991	GAF synthase catalyzed the conversion of 107 nmol of L-arginine into L-citrulline per min per mg of protein.	Arginine	53-63	fibroblast growth factor 9	Rattus norvegicus	0-3
1899564-3	1991	The arginine/lysine preference was determined with three pairs of tripeptidyl-p-nitroanilide substrates having either arginine or lysine in the P1 position and varied from 5.2 to 14.1 for u-PA and from 55.6 to 99.8 for t-PA.	Arginine	4-12	plasminogen activator, urokinase	Homo sapiens	188-192
1899564-3	1991	The arginine/lysine preference was determined with three pairs of tripeptidyl-p-nitroanilide substrates having either arginine or lysine in the P1 position and varied from 5.2 to 14.1 for u-PA and from 55.6 to 99.8 for t-PA.	Arginine	4-12	plasminogen activator, tissue type	Homo sapiens	219-223
1899564-5	1991	However, u-PA had a significantly lower arginine/lysine preference than t-PA, indicating that u-PA represents a less specific proteinase.	Arginine	40-48	plasminogen activator, urokinase	Homo sapiens	9-13
1999249-0	1991	Cyclic and linear vasopressin V1 and V1/V2 antagonists containing arginine in the 4-position.	Arginine	66-74	arginine vasopressin	Homo sapiens	18-29
1703153-11	1991	The combination of heparin and Arg-Gly-Asp-Ser inhibited G361 attachment to TSP.	Arginine	31-34	thrombospondin 1	Homo sapiens	76-79
1719954-4	1991	The results indicate that Ca(2+)-calmodulin directly activates the endothelial nitric oxide synthase, thereby transducing agonist-induced increases in intracellular free Ca2+ concentration to nitric oxide formation from L-arginine, K(+)-induced depolarization of the endothelial cells markedly inhibited the sustained, but not initial phase of the intracellular Ca2+ response to bradykinin, indicating that K(+)-induced depolarization depresses the transmembrane Ca2+ influx.	Arginine	220-230	nitric oxide synthase 3	Homo sapiens	67-100
1678226-2	1991	Peak serum growth hormone response to arginine was compared with peak growth hormone concentration during sleep in 6 children with atopic dermatitis and short stature (greater than 3 SD below the mean) aged 7 to 12 years, and 5 control children aged 9 to 12 years without atopic dermatitis or asthma but with unexplained short stature (greater than 3 SD below the mean).	Arginine	38-46	growth hormone 1	Homo sapiens	11-25
1678226-4	1991	All patients with dermatitis were capable of releasing growth hormone after arginine stimulation.	Arginine	76-84	growth hormone 1	Homo sapiens	55-69
1986681-5	1991	One and 6 mM L-arginine, but not 6 mM D-arginine caused a significant inhibition of HPV by 20 +/- 2 and 47 +/- 12% (p less than 0.05, compared with the vehicle control group) and a small but not significant reduction in A-II-mediated contraction.	Arginine	13-23	angiotensinogen	Rattus norvegicus	220-224
1769204-10	1991	Amino acid sequencing of the first 40 residues of the three prolactin isoforms showed arginine at position 24 and histidine at position 27, for the nonglycosylated form, but no identifiable amino acids were detected at this position for the glycosylated isoforms.	Arginine	86-94	prolactin	Meleagris gallopavo	60-69
1902396-9	1991	The cytotoxicity of M theta activated by Mf-B plus IFN gamma was dependent on L-arginine in the culture, suggesting that arginine metabolites are involved in M theta cytotoxicity.	Arginine	78-88	interferon gamma	Mus musculus	51-60
1902396-9	1991	The cytotoxicity of M theta activated by Mf-B plus IFN gamma was dependent on L-arginine in the culture, suggesting that arginine metabolites are involved in M theta cytotoxicity.	Arginine	80-88	interferon gamma	Mus musculus	51-60
1761067-0	1991	Effect of nifedipine on glucose potentiation of the acute insulin response to arginine in non-insulin-dependent diabetics.	Arginine	78-86	insulin	Homo sapiens	58-65
1761067-2	1991	Pancreatic beta-cell function was assessed as insulin release following stimulation with arginine after potentiation by hyperglycaemia.	Arginine	89-97	insulin	Homo sapiens	46-53
1761067-6	1991	The acute insulin response (AIR) to 5 g arginine after potentiation by hyperglycaemia (clamped at 240 and 350 mg/dl for 30 min) was significantly (P less than 0.05) decreased, as well as the potentiation slope (line relating AIR and plasma glucose level) in those patients, and were unchanged in the control group.	Arginine	40-48	insulin	Homo sapiens	10-17
1986018-6	1991	Insulin release in response to 10 mmol/L L-arginine was preserved in these islets, suggesting a selective reduction of the insulin response to glucose.	Arginine	41-51	insulin	Homo sapiens	0-7
1991487-0	1991	L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation.	Arginine	0-10	tumor necrosis factor	Homo sapiens	82-103
1991487-0	1991	L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation.	Arginine	0-10	interleukin 6	Homo sapiens	111-124
1991487-3	1991	The possible participation of an L-arginine-dependent effector mechanism has been studied to explain the TNF/IL 6-induced inhibition.	Arginine	33-43	tumor necrosis factor	Homo sapiens	105-108
1991487-3	1991	The possible participation of an L-arginine-dependent effector mechanism has been studied to explain the TNF/IL 6-induced inhibition.	Arginine	33-43	interleukin 6	Homo sapiens	109-113
1988465-0	1991	An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion.	Arginine	3-6	coagulation factor II, thrombin	Homo sapiens	31-39
1725333-1	1991	The interaction of endothelin-1 (ET-1), a novel vasoconstrictor peptide synthesized according to the encoded amino acid sequence, with L-NG-nitroarginine (NOARG), an L-arginine-reversible inhibitor of endothelium-derived relaxing factor (EDRF) on adrenergic receptors, was investigated.	Arginine	166-176	endothelin 1	Rattus norvegicus	19-31
1725333-1	1991	The interaction of endothelin-1 (ET-1), a novel vasoconstrictor peptide synthesized according to the encoded amino acid sequence, with L-NG-nitroarginine (NOARG), an L-arginine-reversible inhibitor of endothelium-derived relaxing factor (EDRF) on adrenergic receptors, was investigated.	Arginine	166-176	endothelin 1	Rattus norvegicus	33-37
1986018-6	1991	Insulin release in response to 10 mmol/L L-arginine was preserved in these islets, suggesting a selective reduction of the insulin response to glucose.	Arginine	41-51	insulin	Homo sapiens	123-130
1873900-7	1991	On the contrary, electrolytical lesion of PVN could decrease the effect of AA obviously, which could be recovered by cerebroventricular injection (ICV) of 300 ng of arginine VP.	Arginine	165-173	arginine vasopressin	Rattus norvegicus	174-176
2045542-3	1991	Both sVT and sIT precursors were found to contain a signal peptide and hormone that is connected to a neurophysin by a Gly-Lys-Arg sequence.	Arginine	127-130	signaling threshold regulating transmembrane adaptor 1	Homo sapiens	13-16
1964906-6	1990	The relaxation produced by VIP was slightly reduced by L-NMMA and enhanced by L-arginine.	Arginine	78-88	vasoactive intestinal peptide	Rattus norvegicus	27-30
2123870-4	1990	We have previously demonstrated that mutation of arginine 304 of t-PA to a glutamic acid residue drastically reduces the rate of interaction between the enzyme and its suicide substrate, PAI-1, without affecting the reactivity of the enzyme toward its normal substrate, plasminogen (Madison, E. L., Goldsmith, E. J., Gerard, R.D., Gething, M.J., and Sambrook, J.F.	Arginine	49-57	plasminogen activator, tissue type	Homo sapiens	65-69
2265709-0	1990	Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism.	Arginine	94-104	interleukin 1 beta	Rattus norvegicus	35-86
1979717-2	1990	Cimaterol at 10-100 nM concentrations reduced cathepsin B benzyloxy-carbonyl-Arg-Arg-4-methyl-7-coumarylamide hydrolyzing activity, as well as benzyloxycarbonyl-Phe-Arg-4-methyl-7-coumarylamide hydrolysis, which is a substrate for both cathepsin B and cathepsin L. Maximum effect was observed after 6-16 h treatment.	Arginine	81-84	cathepsin B	Bos taurus	46-57
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	236-246	interleukin 1 beta	Rattus norvegicus	51-69
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	236-246	interleukin 1 beta	Rattus norvegicus	71-80
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	236-246	tumor necrosis factor	Rattus norvegicus	131-140
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	291-301	interleukin 1 beta	Rattus norvegicus	51-69
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	291-301	interleukin 1 beta	Rattus norvegicus	71-80
2265709-1	1990	Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM).	Arginine	291-301	tumor necrosis factor	Rattus norvegicus	131-140
2265709-2	1990	Inhibition of secretion by IL-1 beta was further alleviated when islets were maintained in L-arginine-free medium supplemented with N-omega-nitro-L-arginine methyl ester (NAME), while synergism between IL-1 beta plus TNF-alpha was completely abolished.	Arginine	91-101	interleukin 1 beta	Rattus norvegicus	27-36
2265709-5	1990	In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha.	Arginine	18-28	interleukin 1 beta	Rattus norvegicus	127-136
2265709-5	1990	In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha.	Arginine	18-28	interleukin 1 beta	Rattus norvegicus	191-200
2265709-5	1990	In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha.	Arginine	18-28	tumor necrosis factor	Rattus norvegicus	205-214
2250008-4	1990	The enzyme, named prorenin converting enzyme, specifically cleaves the peptide bond on the COOH-side of the Arg residue at the Lys-Arg pair of mouse Ren 2 prorenin, but does not cleave mouse Ren 1 and human prorenins.	Arginine	108-111	renin 1 structural	Mus musculus	149-152
2250008-4	1990	The enzyme, named prorenin converting enzyme, specifically cleaves the peptide bond on the COOH-side of the Arg residue at the Lys-Arg pair of mouse Ren 2 prorenin, but does not cleave mouse Ren 1 and human prorenins.	Arginine	131-134	renin 1 structural	Mus musculus	149-152
2250008-7	1990	The results also demonstrated that the presence of a Pro residue next to the Lys-Arg pair prevents the processing of Ren 1 prorenin.	Arginine	81-84	renin 1 structural	Mus musculus	117-120
1704357-8	1990	L-NG-monomethyl-arginine (10(-4) M), a specific inhibitor of formation of nitric oxide from L-arginine, antagonised the relaxations induced by substance P, decreasing the maximum response of substance P to 34 +/- 10.5% of the response to glyceryl trinitrate.	Arginine	92-102	tachykinin precursor 1	Homo sapiens	143-154
2082193-1	1990	An abnormal human thyroid hormone beta-receptor (hTR beta-Mf), which has a glycine to arginine substitution in the hormone-binding domain, has been identified in affected members of one family with generalized resistance to thyroid hormone.	Arginine	86-94	telomerase RNA component	Homo sapiens	49-52
2279740-2	1990	TNF-alpha-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine.	Arginine	86-96	tumor necrosis factor	Mus musculus	0-9
2229304-0	1990	Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man.	Arginine	65-73	growth hormone 1	Homo sapiens	0-14
2229304-0	1990	Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man.	Arginine	65-73	growth hormone 1	Homo sapiens	16-18
2229304-2	1990	To obtain new information on this mechanism(s), the GH responses to both single and combined administration of GH-releasing hormone (GHRH; 1 microgram/kg iv) and arginine (ARG; 30 g infused over 30 min), a well known GH secretagogue probably acting via inhibition of hypothalamic somatostatin release, were studied in seven elderly normal subjects and seven young healthy subjects.	Arginine	162-170	growth hormone 1	Homo sapiens	52-54
2229304-5	1990	On the other hand, the ARG-induced GH increase in the elderly was not significantly different from that in young subjects (372.8 +/- 81.8 vs. 470.6 +/- 126.5 micrograms/L.h).	Arginine	23-26	growth hormone 1	Homo sapiens	35-37
2229304-6	1990	ARG potentiated GH responsiveness to GHRH in both elderly (1787.1 +/- 226.0 micrograms/L.h; P = 0.0001 vs. GHRH alone) and young subjects (2113.0 +/- 444.3 micrograms/L.h; P = 0.001 vs. GHRH alone).	Arginine	0-3	growth hormone 1	Homo sapiens	16-18
2229304-6	1990	ARG potentiated GH responsiveness to GHRH in both elderly (1787.1 +/- 226.0 micrograms/L.h; P = 0.0001 vs. GHRH alone) and young subjects (2113.0 +/- 444.3 micrograms/L.h; P = 0.001 vs. GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	37-41
2229304-6	1990	ARG potentiated GH responsiveness to GHRH in both elderly (1787.1 +/- 226.0 micrograms/L.h; P = 0.0001 vs. GHRH alone) and young subjects (2113.0 +/- 444.3 micrograms/L.h; P = 0.001 vs. GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	107-111
2229304-6	1990	ARG potentiated GH responsiveness to GHRH in both elderly (1787.1 +/- 226.0 micrograms/L.h; P = 0.0001 vs. GHRH alone) and young subjects (2113.0 +/- 444.3 micrograms/L.h; P = 0.001 vs. GHRH alone).	Arginine	0-3	growth hormone releasing hormone	Homo sapiens	107-111
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	27-30	growth hormone releasing hormone	Homo sapiens	38-42
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	27-30	growth hormone 1	Homo sapiens	38-40
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	27-30	growth hormone 1	Homo sapiens	51-53
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	27-30	growth hormone releasing hormone	Homo sapiens	230-234
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	222-225	growth hormone releasing hormone	Homo sapiens	38-42
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	222-225	growth hormone 1	Homo sapiens	38-40
2229304-7	1990	The potentiating effect of ARG on the GHRH-induced GH response was greater in elderly than in young subjects (1013.0 +/- 553.5% vs. 237.9 +/- 79.1%; P = 0.0001); thus, the GH increase induced by combined administration of ARG and GHRH overlapped in two groups.	Arginine	222-225	growth hormone 1	Homo sapiens	51-53
2082179-5	1990	In one AR- subject (R774C), amino acid 774 was changed from arginine (CGC) to cysteine (TGC), in another AR- subject (R831Q), arginine (CGA) was changed to glutamine (CAA) at position 831, and in an AR+ subject (V866M) a methionine (ATG) was substituted for valine (GTG) at position 866.	Arginine	60-68	androgen receptor	Homo sapiens	7-9
2082179-5	1990	In one AR- subject (R774C), amino acid 774 was changed from arginine (CGC) to cysteine (TGC), in another AR- subject (R831Q), arginine (CGA) was changed to glutamine (CAA) at position 831, and in an AR+ subject (V866M) a methionine (ATG) was substituted for valine (GTG) at position 866.	Arginine	126-134	chromogranin A	Homo sapiens	136-139
2124106-1	1990	Treatment of EMT 6 mammary adenocarcinoma cells with Interferon-gamma (IFN-gamma, 10 U.ml-1) plus endotoxin lipopolysaccharide (LPS, 100 ng.ml-1) induces concomitantly a growth arrest and production of citrulline and nitrite from L-arginine.	Arginine	230-240	interferon gamma	Mus musculus	53-69
2246970-1	1990	Glucose potentiates arginine-induced insulin release.	Arginine	20-28	insulin	Homo sapiens	37-44
2246970-6	1990	Vmax of both phases of glucose-arginine-stimulated insulin release were positively correlated (r = .75, P less than .05).	Arginine	31-39	insulin	Homo sapiens	51-58
2246970-7	1990	The ED50 of the influence of glucose on first-phase arginine-induced insulin release was significantly lower than the ED50 for the second phase (9.0 +/- 1.1 v 12.7 +/- 1.0 mmol/L, respectively, P less than .02).	Arginine	52-60	insulin	Homo sapiens	69-76
2246970-0	1990	Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release.	Arginine	118-126	insulin	Homo sapiens	138-145
2124106-1	1990	Treatment of EMT 6 mammary adenocarcinoma cells with Interferon-gamma (IFN-gamma, 10 U.ml-1) plus endotoxin lipopolysaccharide (LPS, 100 ng.ml-1) induces concomitantly a growth arrest and production of citrulline and nitrite from L-arginine.	Arginine	230-240	interferon gamma	Mus musculus	71-80
1700979-4	1990	Using mass spectrometry, we determined that the phosphorylation site is threonine 97, present in the conserved triproline loop of MBP, with (partial) sequence -Thr-Pro-Arg-Thr97-Pro-Pro-Pro-.	Arginine	168-171	myelin basic protein	Bos taurus	130-133
2085894-0	1990	Stability of a novel hexapeptide, (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu-OEt, with neurotensin activity, in aqueous solution and in the solid state.	Arginine	38-41	neurotensin	Homo sapiens	77-88
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Arginine	114-117	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	0-3
1963807-7	1990	Similarly, pretreatment of the cells with the L-arginine analogues, L-canavanine (IC50 60 microM) or NG-monomethyl-L-arginine (IC50 2.5 microM), inhibited the cyclic GMP response to endothelin-1.	Arginine	46-56	endothelin 1	Rattus norvegicus	182-194
1963807-8	1990	Therefore, endothelin-1 activates guanylate cyclase most probably via formation of nitric oxide, which is released from L-arginine.	Arginine	120-130	endothelin 1	Rattus norvegicus	11-23
2208809-4	1990	In addition, natural human C5ades Arg and natural porcine C5a were able to induce a similar level of IL-6.	Arginine	34-37	complement C5a receptor 1	Homo sapiens	27-30
2208809-4	1990	In addition, natural human C5ades Arg and natural porcine C5a were able to induce a similar level of IL-6.	Arginine	34-37	interleukin 6	Homo sapiens	101-105
2122744-0	1990	Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries.	Arginine	24-34	kininogen 1	Homo sapiens	46-56
2085894-1	1990	The stability and some physicochemical properties of a novel hexapeptide, (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu-OEt (I), with neurotensin activity, were investigated.	Arginine	78-81	neurotensin	Homo sapiens	121-132
2172027-5	1990	NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.	Arginine	15-25	interleukin 1 beta	Homo sapiens	37-46
2101409-5	1990	Sequence analysis of lysyl endopeptidase fragments showed that apo E-Kochi differs from normal apo E3 at residue 145, where an arginine residue is substituted for histidine.	Arginine	127-135	apolipoprotein E	Homo sapiens	63-68
2145179-8	1990	Therefore, arginine at position 4 of the processed IL-1 beta molecule was shown to be a key residue in the function of IL-1 beta as a hematopoietic regulator.	Arginine	11-19	interleukin 1 beta	Homo sapiens	51-60
2145179-8	1990	Therefore, arginine at position 4 of the processed IL-1 beta molecule was shown to be a key residue in the function of IL-1 beta as a hematopoietic regulator.	Arginine	11-19	interleukin 1 beta	Homo sapiens	119-128
2172027-5	1990	NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.	Arginine	15-25	tumor necrosis factor	Homo sapiens	52-61
2270538-3	1990	A C to T transition at nucleotide 30,863 changes codon 248 from Arg (CGA) to a new Stop codon (TGA), described in a previous family as factor IXMalmo3 (Green P M et al., EMBO J 1989; 8: 1067).	Arginine	64-67	chromogranin A	Homo sapiens	69-72
2226434-11	1990	The preference of thrombin for distinctly substituted piperidine derivatives and its generally higher (compared with trypsin) affinity for benzamidine and arginine-based inhibitors can be accounted for by these thrombin inhibitor models.	Arginine	155-163	coagulation factor II, thrombin	Homo sapiens	18-26
2223883-2	1990	Partial cDNA overlapped the apo E mRNA sequence coding for apo E binding domain towards the LDL(B/E) receptor up to codon for Arg-139.	Arginine	126-129	apolipoprotein E	Homo sapiens	28-33
2223883-2	1990	Partial cDNA overlapped the apo E mRNA sequence coding for apo E binding domain towards the LDL(B/E) receptor up to codon for Arg-139.	Arginine	126-129	apolipoprotein E	Homo sapiens	59-64
2170375-10	1990	A domain on the GRP molecule involving Lys-13 or Arg-17 was identified which promoted binding to the GRP receptor under conditions of low ionic strength.	Arginine	49-52	gastrin releasing peptide	Mus musculus	16-19
2170375-10	1990	A domain on the GRP molecule involving Lys-13 or Arg-17 was identified which promoted binding to the GRP receptor under conditions of low ionic strength.	Arginine	49-52	gastrin releasing peptide	Mus musculus	101-104
2221580-8	1990	Consistent with these observations, smoke-treated CFI exhibited a decreased capacity to bind to GcG and a decreased capacity to inhibit the binding of C5a des Arg to GcG.	Arginine	159-162	complement C5a receptor 1	Homo sapiens	151-154
1701676-2	1990	The activation of the L-arginine: nitric oxide (NO) pathway during aggregation of human platelets by adenosine 5"-diphosphate (ADP), arachidonic acid, thrombin and the calcium ionophore A23187 and its inhibition by NG-monomethyl-L-arginine (L-NMMA), NG-nitro-L-arginine methyl ester (L-NAME) and N-iminoethyl-L-ornithine (L-NIO) were studied.	Arginine	22-32	coagulation factor II, thrombin	Homo sapiens	151-159
2270318-1	1990	We sought to clarify the mechanisms of growth hormone (GH) secretion induced by insulin hypoglycemia, L-dopa, and arginine in man.	Arginine	114-122	growth hormone 1	Homo sapiens	39-53
2270318-7	1990	Coadministration of GHRH accentuated the stimulatory effect of arginine on GH secretion.	Arginine	63-71	growth hormone releasing hormone	Homo sapiens	20-24
2226434-11	1990	The preference of thrombin for distinctly substituted piperidine derivatives and its generally higher (compared with trypsin) affinity for benzamidine and arginine-based inhibitors can be accounted for by these thrombin inhibitor models.	Arginine	155-163	coagulation factor II, thrombin	Homo sapiens	211-219
1976733-5	1990	This leads, at the translation level, to the substitution of an arginine residue (positively charged) in C3 S for a glycine residue (neutral) in C3 F.	Arginine	64-72	lysophosphatidylcholine acyltransferase 3	Homo sapiens	145-149
1976091-5	1990	Both glucagon and insulin were maximally stimulated in a glucagon/insulin molar ratio of 0.029 by arginine concentrations of 25-50 nM, and the concentration of arginine that provided half-maximum responses for both hormones was approximately 3 mM.	Arginine	98-106	insulin	Homo sapiens	18-25
1976091-5	1990	Both glucagon and insulin were maximally stimulated in a glucagon/insulin molar ratio of 0.029 by arginine concentrations of 25-50 nM, and the concentration of arginine that provided half-maximum responses for both hormones was approximately 3 mM.	Arginine	98-106	insulin	Homo sapiens	66-73
1976091-5	1990	Both glucagon and insulin were maximally stimulated in a glucagon/insulin molar ratio of 0.029 by arginine concentrations of 25-50 nM, and the concentration of arginine that provided half-maximum responses for both hormones was approximately 3 mM.	Arginine	160-168	insulin	Homo sapiens	18-25
2123470-2	1990	An arginine for glycine substitution in apolipoprotein A-I identified in the proband"s amyloid fibrils was determined to be the result of a mutation of guanine to cytosine in the apolipoprotein A-I gene at the position corresponding to the first base of codon 26.	Arginine	3-11	apolipoprotein A1	Homo sapiens	40-58
2123470-2	1990	An arginine for glycine substitution in apolipoprotein A-I identified in the proband"s amyloid fibrils was determined to be the result of a mutation of guanine to cytosine in the apolipoprotein A-I gene at the position corresponding to the first base of codon 26.	Arginine	3-11	apolipoprotein A1	Homo sapiens	179-197
2118219-4	1990	Impaired integrated GH response to GRH, arginine, and L-dopa in obese subjects was significantly restored after weight reduction (P less than .01).	Arginine	40-48	growth hormone 1	Homo sapiens	20-22
2219271-4	1990	By contrast, insulin release induced by 17 mmol/L arginine is not affected.	Arginine	50-58	insulin	Homo sapiens	13-20
2394713-7	1990	It has a neutral pH optimum and cleaves COOH-terminal Arg or Lys in bradykinin and in shorter peptides.	Arginine	54-57	kininogen 1	Canis lupus familiaris	68-78
2240004-1	1990	In seven normal volunteers, the basal and arginine-stimulated levels of plasma growth hormone, glucose, glucagon, and free fatty acids and serum insulin was determined during placebo and during indomethacin 25 mg four times daily.	Arginine	42-50	growth hormone 1	Homo sapiens	79-93
2240004-3	1990	Despite lack of effect on plasma glucagon, indomethacin decreased the insulin response to arginine.	Arginine	90-98	insulin	Homo sapiens	70-77
2240004-4	1990	The fall in free fatty acids during arginine infusion was decreased by indomethacin, which may in part be due to increased plasma growth hormone levels.	Arginine	36-44	growth hormone 1	Homo sapiens	130-144
2394775-12	1990	The maximal GH response during the arginine tolerance test was normal in 66% of the children.	Arginine	35-43	growth hormone 1	Homo sapiens	12-14
1699121-3	1990	In contrast, the N-terminal SP1-4 fragment (Arg-Pro-Lys-Pro) suppressed the response at a dose of 0.1 microgram/ml, but stimulated it slightly at higher doses (1-5 micrograms/ml).	Arginine	44-47	Sp1 transcription factor	Homo sapiens	28-33
2118219-0	1990	Very-low-calorie diet-induced weight reduction reverses impaired growth hormone secretion response to growth hormone-releasing hormone, arginine, and L-dopa in obesity.	Arginine	136-144	growth hormone 1	Homo sapiens	65-79
2118219-3	1990	GH response to GRH, arginine, and L-dopa in obese subjects was markedly impaired before weight reduction, whereas significantly increased responses were noted after weight reduction (P less than .01).	Arginine	20-28	growth hormone 1	Homo sapiens	0-2
2284201-4	1990	The amino acid sequence of the peptide, Ala-Leu-Asn-Ser-Val-Ala-Tyr-Glu-Arg-Ser-Ala-Met-Gln-Asn-Tyr-Glu, indicates identity with beta-preprotachykinin(111-126)-peptide.	Arginine	72-75	tachykinin precursor 1	Homo sapiens	134-150
2390089-5	1990	The RYD sequence of streptavidin thus mimics RGD (Arg-Gly-Asp), the universal recognition domain present in fibronectin and other adhesion-related molecules.	Arginine	50-53	fibronectin 1	Homo sapiens	108-119
2117605-1	1990	The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately.	Arginine	66-76	interferon gamma	Mus musculus	99-115
2117605-1	1990	The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately.	Arginine	66-76	interferon gamma	Mus musculus	117-126
2387866-2	1990	C1-r alpha extended from residues 1 to 208 of C1-r A chain, with at least two cleavage sites within disulfide loops, after lysine 134 and arginine 202.	Arginine	138-146	complement C1r	Homo sapiens	0-4
2387866-3	1990	C1-s alpha comprised residues 1-192 of the C1-s A chain, with one cleavage site within a disulfide loop, after arginine 186.	Arginine	111-119	complement C1s	Homo sapiens	0-4
2200274-4	1990	When a primed continuous infusion of arginine was superimposed on the hyperglycemia, the plasma insulin response was also markedly lower (66%) in the trained subjects, reaching peak values of 333 +/- 68 and 974 +/- 188 microU/ml for trained and untrained subjects, respectively (P less than 0.005).	Arginine	37-45	insulin	Homo sapiens	96-103
2166475-0	1990	Modification of arginine residues in human growth hormone by 1,2-cyclohexanedione: effects on the binding capacity to lactogenic and somatogenic receptors.	Arginine	16-24	growth hormone 1	Homo sapiens	43-57
2166475-1	1990	Reactivity of arginine residues in human growth hormone was studied by reaction with 1,2-cyclohexanedione.	Arginine	14-22	growth hormone 1	Homo sapiens	41-55
2166475-2	1990	Kinetic analysis of the data showed a good fit to a pseudo first order curve, with an apparent velocity constant k = 1.26 x 10(-2) min-1 and a maximum modification of 9.6 out of the 11 arginines of the molecule.	Arginine	185-194	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
2200274-5	1990	When insulin secretion was further stimulated during the arginine-infused hyperglycemia by the ingestion of a high-fat meal, peak insulin concentrations averaged 989 +/- 205 microU/ml in the trained compared with 2,232 +/- 455 microU/ml in the untrained subjects (P less than 0.01).	Arginine	57-65	insulin	Homo sapiens	5-12
2226525-6	1990	With controlled proteolytic hydrolysis, we found that the interaction of LDL with CSPG modifies the surface accessibility of a apoB-100 segments containing arginine and lysine.	Arginine	156-164	apolipoprotein B	Homo sapiens	127-135
2169933-0	1990	Measurement of (C13)arginine incorporation into apolipoprotein B-100 in very low density lipoproteins and low density lipoproteins in normal subjects using (13C)sodium bicarbonate infusion and isotope ratio mass spectrometry.	Arginine	20-28	apolipoprotein B	Homo sapiens	48-68
1982090-2	1990	In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone.	Arginine	86-89	growth hormone releasing hormone	Homo sapiens	155-159
1982090-2	1990	In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone.	Arginine	172-175	growth hormone releasing hormone	Homo sapiens	60-64
1982090-2	1990	In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone.	Arginine	172-175	growth hormone releasing hormone	Homo sapiens	155-159
1982090-2	1990	In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone.	Arginine	172-175	growth hormone releasing hormone	Homo sapiens	60-64
1982090-2	1990	In 4 normal subjects, a bolus injection of 50 micrograms of GHRH followed by 0.5 g/kg Arg infusion after 90 min evoked two GH peaks and the priming of the GHRH potentiated Arg-induced GH peak by 88% of that by Arg alone.	Arginine	172-175	growth hormone releasing hormone	Homo sapiens	155-159
2386204-8	1990	After boiling at 100 degrees C for 10 minutes, C5a (C5ades Arg) lost its leukocytosis activity, indicating that the cellular effect was not caused by endotoxin.	Arginine	59-62	complement C5a receptor 1	Homo sapiens	47-50
1982090-3	1990	In contrast, Arg pretreatment suppressed the GHRH-induced GH peak to a level of 15%.	Arginine	13-16	growth hormone releasing hormone	Homo sapiens	45-49
1982090-8	1990	In 4 other normal subjects, the effect of endogenous GH fluctuation on the GHRH-Arg test was examined in the morning, afternoon and evening.	Arginine	80-83	growth hormone releasing hormone	Homo sapiens	75-79
1982090-11	1990	The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg.	Arginine	9-12	growth hormone releasing hormone	Homo sapiens	4-8
1982090-11	1990	The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg.	Arginine	9-12	growth hormone releasing hormone	Homo sapiens	100-104
1982090-11	1990	The GHRH-Arg test is therefore able to evaluate GH secretory dynamics through two major mechanisms, GHRH stimulation and SRIH inhibition in a single procedure, reducing the incidence of false negative GH response to Arg.	Arginine	216-219	growth hormone releasing hormone	Homo sapiens	4-8
2198571-0	1990	The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.	Arginine	32-35	Abl tyrosine kinase	Drosophila melanogaster	48-55
2280190-3	1990	The primary structure of apoE3 differs from that of apoE4 at only a single site; apoE3 has its sole cysteine residue at position 112, while apoE4 contains arginine at position 112 and completely lacks cysteine.	Arginine	155-163	apolipoprotein E	Homo sapiens	25-30
2280190-3	1990	The primary structure of apoE3 differs from that of apoE4 at only a single site; apoE3 has its sole cysteine residue at position 112, while apoE4 contains arginine at position 112 and completely lacks cysteine.	Arginine	155-163	apolipoprotein E	Homo sapiens	140-145
2280190-7	1990	Cysteamine modification of apoE3 resulted in an apoE4-like distribution, demonstrating that a positive charge at position 112 determined the apoE4 distribution and that the effect was not exclusively due to the presence of arginine at this position.	Arginine	223-231	apolipoprotein E	Homo sapiens	27-32
1697752-5	1990	Other features deduced from the bovine IGFBP-2 cDNA include: an abundance of leucine in the pre-peptide, an Arg-Gly-Asp sequence, absence of N-linked glycosylation sites, and an imperfect polyadenylation signal as well as an ATTTA motif in the 3" non-coding DNA.	Arginine	108-111	insulin like growth factor binding protein 2	Bos taurus	39-46
2217145-0	1990	Alteration in folding efficiency and conformation of recombinant human tumor necrosis factor-alpha by replacing cysteines 69 and 101 with aspartic acid 69 and arginine 101.	Arginine	159-167	tumor necrosis factor	Homo sapiens	71-98
2203725-5	1990	The insulin response was biphasic and waned despite increasing arginine concentrations.	Arginine	63-71	insulin	Homo sapiens	4-11
2075783-0	1990	Quantitative and qualitative differences in basal and glucose- and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM.	Arginine	67-75	insulin	Homo sapiens	87-94
2075783-5	1990	Glucose and arginine triggered insulin release was greater than in healthy subjects at almost identical area under the respective substrate concentration curve (AUC/kg body weight) in obese subjects without (2-fold) and with impaired glucose tolerance (4-fold), and in NIDDMs following i.v.	Arginine	12-20	insulin	Homo sapiens	31-38
2203725-0	1990	Diminished arginine-stimulated insulin secretion in trained men.	Arginine	11-19	insulin	Homo sapiens	31-38
2114220-5	1990	Sequencing revealed that one mutant allele contains a T----C transition changing a leucine to a proline; another NF1 allele harbors a C----T transition changing an arginine to a stop codon.	Arginine	164-172	neurofibromin 1	Homo sapiens	113-116
2114233-0	1990	Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosis.	Arginine	151-154	tissue-type plasminogen activator	Canis lupus familiaris	28-61
2203725-10	1990	The responses of glucagon- and growth hormone-secreting cells to arginine do not change with training.	Arginine	65-73	growth hormone 1	Homo sapiens	31-45
1696304-3	1990	Arginine (5 mmol/l) and 3-isobutyl-l-methylxanthine (1 mmol/l) potentiated insulin release induced by 8.3 mmol glucose/l.	Arginine	0-8	insulin	Homo sapiens	75-82
2374004-5	1990	The CP produced by proteolytic cleavage at the Arg/Gly site between residues 680 and 681 contains 504 amino acids (Mr 56019) and has hydrophobic properties.	Arginine	47-50	golgi phosphoprotein 3	Homo sapiens	4-6
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Arginine	120-123	integrin subunit alpha 5	Homo sapiens	0-5
1972721-7	1990	VLA-5-dependent binding to FN but not costimulation by FN can be specifically blocked with peptides containing the RGD (arg-gly-asp) tripeptide sequence whereas VLA-4-dependent binding and costimulation can both be efficiently inhibited by a 12 amino acid peptide, LHGPEILDVPST (leu-his-gly-pro-glu-iso-leu-asp-val-pro-ser-thr), derived from the alternatively spliced IIICS region of FN.	Arginine	120-123	fibronectin 1	Homo sapiens	27-29
2374004-6	1990	The Arg/Gly cleavage site deduced by N-terminal amino acid sequence analysis is the first for a nepovirus coat protein and for plant viruses expressing their genomic RNAs by polyprotein synthesis.	Arginine	4-7	golgi phosphoprotein 3	Homo sapiens	106-118
2198232-2	1990	In healthy subjects, oral administration of 3.2 g daily of ASA for 3 days significantly enhanced a) basal insulin levels (p less than 0.01), b) arginine-stimulated insulin secretion (25 g i.v.	Arginine	144-152	insulin	Homo sapiens	164-171
2114512-0	1990	Reduced sensitivity to pirenzepine-induced blockade of growth hormone responses to arginine, exercise, and growth hormone-releasing hormone in type I diabetic subjects.	Arginine	83-91	growth hormone 1	Homo sapiens	55-69
2114512-2	1990	Therefore, we investigated in a dose-response fashion the inhibitory effect of the muscarinic cholinergic receptor antagonist pirenzepine on the GH responses to arginine infusion (30 g infused intravenously (IV) in 30 minutes), exercise (bicycle ergometer test at an intensity of 75 W for 30 minutes), or 1-44 GH-releasing hormone (GHRH) (1 microgram/kg in an IV bolus).	Arginine	161-169	growth hormone 1	Homo sapiens	145-147
2114512-6	1990	Diabetic patients presented higher GH responses to stimulation with arginine or exercise than normal controls.	Arginine	68-76	growth hormone 1	Homo sapiens	35-37
2114512-7	1990	In both groups, pirenzepine administered at doses ranging from 20 to 30 mg produced a dose-related inhibition of the GH response to arginine and exercise, which was almost complete when 30 mg pirenzepine was administered.	Arginine	132-140	growth hormone 1	Homo sapiens	117-119
2191958-7	1990	This double modification was made because C1-inhibitor, the natural inhibitor of C1s, has Arg and Ala residues at positions P1 and P2.	Arginine	90-93	complement C1s	Homo sapiens	81-84
2191958-8	1990	Plasminogen activator inhibitor 1, the natural inhibitor of t-PA, also has Arg and Ala residues at positions P1 and P2.	Arginine	75-78	plasminogen activator, tissue type	Homo sapiens	60-64
1694691-1	1990	The substrate specificity of bovine brain myelin basic protein (MBP)-specific protein methylase I (S-adenosyl-L-methionine:protein-L-arginine N-methyltransferase, EC 2.1.1.23), which methylates arginine residues of protein, has been studied using various MBPs, several synthetic peptides and heterogeneous nuclear ribonucleoprotein complex protein (hnRNP).	Arginine	133-141	myelin basic protein	Bos taurus	42-62
1694691-1	1990	The substrate specificity of bovine brain myelin basic protein (MBP)-specific protein methylase I (S-adenosyl-L-methionine:protein-L-arginine N-methyltransferase, EC 2.1.1.23), which methylates arginine residues of protein, has been studied using various MBPs, several synthetic peptides and heterogeneous nuclear ribonucleoprotein complex protein (hnRNP).	Arginine	133-141	myelin basic protein	Bos taurus	64-67
1974484-0	1990	Arginine potentiates the GHRH- but not the pyridostigmine-induced GH secretion in normal short children.	Arginine	0-8	growth hormone releasing hormone	Homo sapiens	25-29
1974484-8	1990	In conclusion, our results show that in children ARG administration potentiates GHRH- but not PD-induced GH increase.	Arginine	49-52	growth hormone releasing hormone	Homo sapiens	80-84
1974484-10	1990	Combined administration of either ARG or PD with GHRH has a similar striking GH-releasing effect which is clearly higher than that of GHRH alone.	Arginine	34-37	growth hormone releasing hormone	Homo sapiens	134-138
1693626-0	1990	Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells.	Arginine	49-52	fibronectin 1	Homo sapiens	87-98
1693626-1	1990	Association of a novel beta 1-related subunit with alpha v. We report the isolation from two human neuroblastoma cell lines of an Arg-Gly-Asp-dependent integrin complex capable of binding to vitronectin, fibronectin, and type I collagen.	Arginine	130-133	fibronectin 1	Homo sapiens	204-215
1697660-5	1990	On the contrary, in other 8 children, PD and Arg induced similar GH increases either when administered alone (394.2 +/- 68.5 vs. 405.8 +/- 103.9 micrograms/l/h) or in combination (535.8 +/- 97.3 micrograms/l/h).	Arginine	45-48	growth hormone 1	Homo sapiens	65-67
2235674-2	1990	We found that: 1) AVP(4-8) and its cysteinyl methyl ester were more potent in the behavioral response than its D-Arg homologs; 2) the methyl ester derivative was the most effective analog in this behavioral test among the peptides we synthesized, with a potency 40 times as high as AVP; 3) neither the D- nor the L-Arg short derivatives of AVP showed any peripheral effects up to a dose thousands of times greater than AVP.	Arginine	313-318	arginine vasopressin	Rattus norvegicus	18-21
2194797-10	1990	The deduced amino acid sequence of GAP1 protein presents strong similarities to those of the yeast arginine, histidine and proline permeases, suggesting a common evolutionary origin for these amino acid permeases.	Arginine	99-107	amino acid permease GAP1	Saccharomyces cerevisiae S288C	35-39
1692038-10	1990	These C----T transitions result in the substitution of Arg-22 and Arg-83 of the mature SCAD with Trp and Cys, respectively.	Arginine	55-58	acyl-CoA dehydrogenase short chain	Homo sapiens	87-91
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	93-96	insulin	Homo sapiens	3-10
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	101-104	insulin	Homo sapiens	3-10
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	101-104	insulin	Homo sapiens	3-10
1973901-3	1990	The first C of this codon has been substituted by T resulting in the non-conservative substitution of cysteine for arginine at an essential thrombin cleavage site in factor VIII.	Arginine	115-123	coagulation factor II, thrombin	Homo sapiens	140-148
2258583-1	1990	Growth hormone (GH) induces lipolysis and an increase of free fatty acids (FFA), and FFA inhibit the GH response to arginine and to GH-releasing hormone (GHRH).	Arginine	116-124	growth hormone 1	Homo sapiens	0-14
2258583-1	1990	Growth hormone (GH) induces lipolysis and an increase of free fatty acids (FFA), and FFA inhibit the GH response to arginine and to GH-releasing hormone (GHRH).	Arginine	116-124	growth hormone 1	Homo sapiens	16-18
2258583-1	1990	Growth hormone (GH) induces lipolysis and an increase of free fatty acids (FFA), and FFA inhibit the GH response to arginine and to GH-releasing hormone (GHRH).	Arginine	116-124	growth hormone 1	Homo sapiens	101-103
1692038-10	1990	These C----T transitions result in the substitution of Arg-22 and Arg-83 of the mature SCAD with Trp and Cys, respectively.	Arginine	66-69	acyl-CoA dehydrogenase short chain	Homo sapiens	87-91
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	210-213	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
1691439-3	1990	This neuronal exon (the NII exon) of C-SRC was isolated from human adult and fetal brain-derived cDNAs and contains 33 nucleotides capable of encoding 11 amino acids (Gln-Thr-Trp-Phe-Thr-Phe-Arg-Trp-Leu-Gln-Arg).	Arginine	191-194	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-42
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	endogenous retrovirus group W member 1, envelope	Homo sapiens	96-99
2339130-4	1990	After amplification of the gene segment encoding the prepro sequence of albumin, specific hybridization of DNA to an oligonucleotide probe encoding cysteine at position -2 indicated the mutation of arginine at the -2 position to cysteine (-2 Arg----Cys).	Arginine	198-206	albumin	Homo sapiens	72-79
1971441-7	1990	Arginine (in the presence of low glucose, i.e., 3.3 mM) moderately stimulated somatostatin secretion in controls but fourfold more in STZ rats.	Arginine	0-8	somatostatin	Rattus norvegicus	78-90
1971441-8	1990	Preperfusion with high glucose markedly potentiated subsequent arginine-induced somatostatin secretion in controls but failed to do so in STZ rats.	Arginine	63-71	somatostatin	Rattus norvegicus	80-92
2333306-7	1990	The effect of NG-methyl-L-arginine on TNF-induced hypotension was antagonized, and the hypotension restored, by administration of excess L-arginine (100 mg/kg, i.v.).	Arginine	24-34	tumor necrosis factor	Homo sapiens	38-41
2339130-2	1990	Structural study established that the major variant component was arginyl-albumin, in which arginine at the -1 position of the propeptide is still attached to the processed albumin.	Arginine	92-100	albumin	Homo sapiens	74-81
2324107-2	1990	This degradation proceeds from the COOH-terminal end of the molecule, and CPA itself makes an important and unexpected contribution by excising the COOH-terminal arginine residue of the released primary activation fragment.	Arginine	162-170	carboxypeptidase A1	Homo sapiens	74-77
2339130-2	1990	Structural study established that the major variant component was arginyl-albumin, in which arginine at the -1 position of the propeptide is still attached to the processed albumin.	Arginine	92-100	albumin	Homo sapiens	173-180
2112946-5	1990	Substitution of arginine-275 provided an analogue [( R275G]t-PA) resistant to plasmin cleavage.	Arginine	16-24	plasminogen activator, tissue type	Homo sapiens	59-63
2180665-0	1990	Insulin response to arginine in puberty.	Arginine	20-28	insulin	Homo sapiens	0-7
2108924-2	1990	The variant, ApoA1 Baltimore, was due to a mutation at codon 34 of the third exon of the APOA1 gene (CGA to CTA) that resulted in an arginine-to-leucine substitution at the tenth amino acid of the mature ApoA1 and a change in charge of -1.	Arginine	133-141	chromogranin A	Homo sapiens	101-104
2108924-2	1990	The variant, ApoA1 Baltimore, was due to a mutation at codon 34 of the third exon of the APOA1 gene (CGA to CTA) that resulted in an arginine-to-leucine substitution at the tenth amino acid of the mature ApoA1 and a change in charge of -1.	Arginine	133-141	apolipoprotein A1	Homo sapiens	13-18
2108924-2	1990	The variant, ApoA1 Baltimore, was due to a mutation at codon 34 of the third exon of the APOA1 gene (CGA to CTA) that resulted in an arginine-to-leucine substitution at the tenth amino acid of the mature ApoA1 and a change in charge of -1.	Arginine	133-141	apolipoprotein A1	Homo sapiens	89-94
2108924-2	1990	The variant, ApoA1 Baltimore, was due to a mutation at codon 34 of the third exon of the APOA1 gene (CGA to CTA) that resulted in an arginine-to-leucine substitution at the tenth amino acid of the mature ApoA1 and a change in charge of -1.	Arginine	133-141	apolipoprotein A1	Homo sapiens	204-209
2186807-4	1990	Renin pH dependence was evaluated between pH 4.0 and 8.0 by using a synthetic substrate identical with the amino terminus of porcine angiotensinogen (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu*Leu-Val-Tyr-Ser, where the asterisk indicates the scissile peptide bond and the proximal histidine is in italics) and an analogous tetradecapeptide where the proximal histidine was substituted with glutamine.	Arginine	154-157	renin	Homo sapiens	0-5
2325102-0	1990	The clinical features of three babies with osteogenesis imperfecta resulting from the substitution of glycine by arginine in the pro alpha 1(I) chain of type I procollagen.	Arginine	113-121	collagen type I alpha 2 chain	Homo sapiens	153-171
2325102-1	1990	The features of three babies with lethal perinatal osteogenesis imperfecta resulting from the substitution of glycine by arginine in the pro alpha 1(I) chain of type I procollagen were studied.	Arginine	121-129	collagen type I alpha 2 chain	Homo sapiens	161-179
2313120-0	1990	Inflammatory properties of human C5a and C5a des Arg in mast cell-depleted human skin.	Arginine	49-52	complement C5a receptor 1	Homo sapiens	41-44
2407519-5	1990	Glucose-induced insulin secretion (7.8 mM glucose) and arginine-induced insulin secretion (10 mM arginine plus 7.8 mM glucose) were inhibited equally (40%) by 2 ng/ml IGF-I.	Arginine	55-63	insulin like growth factor 1	Homo sapiens	167-172
2322257-0	1990	Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.	Arginine	43-53	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	29-31
2322257-1	1990	NG-monomethyl-L-arginine (MeArg) inhibits the release of endothelium-derived relaxing factor (EDRF) from endothelial cells (EC) and the formation of nitric oxide (NO) from L-arginine (Arg) in EC and activated macrophages.	Arginine	14-24	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	0-2
2322257-1	1990	NG-monomethyl-L-arginine (MeArg) inhibits the release of endothelium-derived relaxing factor (EDRF) from endothelial cells (EC) and the formation of nitric oxide (NO) from L-arginine (Arg) in EC and activated macrophages.	Arginine	28-31	dimethylarginine dimethylaminohydrolase 1	Rattus norvegicus	0-2
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	103-106	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	103-106	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	103-106	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	103-106	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
1969350-11	1990	It is thus proposed that the CD4-HLA class II interaction negatively regulates antigen-independent adhesion of T cells, this interaction involving the highly conserved Arg-Phe-Asp-Ser sequence in the HLA class II beta 1 sequence as a CD4-binding site.	Arginine	168-171	CD4 molecule	Homo sapiens	29-32
1969350-11	1990	It is thus proposed that the CD4-HLA class II interaction negatively regulates antigen-independent adhesion of T cells, this interaction involving the highly conserved Arg-Phe-Asp-Ser sequence in the HLA class II beta 1 sequence as a CD4-binding site.	Arginine	168-171	CD4 molecule	Homo sapiens	234-237
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	46-53
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2322258-1	1990	To study whether the G----T point mutation of insulin proreceptors at the cleavage site which changed -Arg-Lys-Arg-Arg- to -Arg-Lys-Arg-Ser- caused unprocessed insulin receptors with decreased insulin binding affinity, we performed transfection of cDNA with the mutation in COS 7 cells and examined the expressed insulin receptors.	Arginine	111-114	insulin	Homo sapiens	160-167
2313096-3	1990	Gc-Globulin (GcG) can function as a cochemotaxin for C5a by binding to C5a or C5a des Arg and enhancing its chemotactic potency.	Arginine	86-89	complement C5a receptor 1	Homo sapiens	53-56
2313096-13	1990	Furthermore, the direct interaction of CFI with C5a and C5a des Arg was assessed by ELISA tests and column chromatography and no interaction was observed.	Arginine	64-67	complement C5a receptor 1	Homo sapiens	56-59
2407519-5	1990	Glucose-induced insulin secretion (7.8 mM glucose) and arginine-induced insulin secretion (10 mM arginine plus 7.8 mM glucose) were inhibited equally (40%) by 2 ng/ml IGF-I.	Arginine	97-105	insulin like growth factor 1	Homo sapiens	167-172
2407519-9	1990	We conclude from these results that 1) IGF-I at physiological concentrations is a potent inhibitor of both glucose- and arginine-induced insulin secretion; 2) the magnitude of the inhibition depends on the background glucose concentration; and 3) the inhibition fully reverses when IGF-I is stopped.	Arginine	120-128	insulin like growth factor 1	Homo sapiens	39-44
2407519-9	1990	We conclude from these results that 1) IGF-I at physiological concentrations is a potent inhibitor of both glucose- and arginine-induced insulin secretion; 2) the magnitude of the inhibition depends on the background glucose concentration; and 3) the inhibition fully reverses when IGF-I is stopped.	Arginine	120-128	insulin like growth factor 1	Homo sapiens	282-287
2407296-8	1990	The other pigeon metallothionein has lysine at its carboxyl terminus and is devoid of arginine.	Arginine	86-94	metallothionein 4	Gallus gallus	17-32
2139248-1	1990	Tissue plasminogen activator (t-PA) is homologous to other serine proteases and contains an apparent activation cleavage site at arginine 275.	Arginine	129-137	plasminogen activator, tissue type	Homo sapiens	0-34
2154196-0	1990	IFN-gamma-activated macrophages: detection by electron paramagnetic resonance of complexes between L-arginine-derived nitric oxide and non-heme iron proteins.	Arginine	99-109	interferon gamma	Mus musculus	0-9
2154196-1	1990	Interferon-gamma induces the L-Arginine-dependent pathway that leads to the formation of nitrogen oxides in murine macrophages with subsequent inhibition of mitochondrial non-heme iron-dependent enzymes.	Arginine	29-39	interferon gamma	Mus musculus	0-16
2271010-3	1990	The affinity of native hirudin does not differ significantly from that of recombinant hirudin Lys-47 whereas a distinctly lower affinity for thrombin is found for recombinant hirudin Arg-47 and recombinant hirudin Asn-47.	Arginine	183-186	coagulation factor II, thrombin	Homo sapiens	141-149
2302209-3	1990	The adsorbed Met-enkephalin-Arg-Arg was eluted at pH 4.0 and confirmed to be unaltered.	Arginine	28-31	proopiomelanocortin	Homo sapiens	13-27
2302209-3	1990	The adsorbed Met-enkephalin-Arg-Arg was eluted at pH 4.0 and confirmed to be unaltered.	Arginine	32-35	proopiomelanocortin	Homo sapiens	13-27
2302209-4	1990	In the apocarboxypeptidase B-Sepharose chromatography, Met-enkephalin-Arg-Arg or dynorphin 1-13 (YGGFLRRIRPKLK), substrates of carboxypeptidase B, was separated from Met-enkephalin (YGGFM), dynorphin B 1-9 (YGGFLRRQF), and beta-neo-endorphin (YGGFLRKYP) which do not react with the immobilized enzyme.	Arginine	70-73	proopiomelanocortin	Homo sapiens	55-69
2302209-4	1990	In the apocarboxypeptidase B-Sepharose chromatography, Met-enkephalin-Arg-Arg or dynorphin 1-13 (YGGFLRRIRPKLK), substrates of carboxypeptidase B, was separated from Met-enkephalin (YGGFM), dynorphin B 1-9 (YGGFLRRQF), and beta-neo-endorphin (YGGFLRKYP) which do not react with the immobilized enzyme.	Arginine	70-73	proopiomelanocortin	Homo sapiens	166-180
2295598-11	1990	An arginine at position 503 was missing from the sequence cycle performed by Edman degradation of the modified peptide, but arginine was present in the identical peptide isolated from native dopamine beta-hydroxylase.	Arginine	124-132	dopamine beta-hydroxylase	Bos taurus	191-216
1715119-2	1990	This peptide represents residues Glu1737-Ser1750 of the mature von Willebrand factor (vWF) subunit and contains the sequence Arg-Gly-Asp, thought to be important in mediating binding to the platelet receptor glycoprotein (GP) IIb-IIIa complex.	Arginine	125-128	von Willebrand factor	Homo sapiens	86-89
1715119-5	1990	In particular, two antibodies bound to epitopes on vWF that included one or more of the three residues (arginine, glycine, aspartic acid) thought to be involved in binding to GP IIb-IIIa, whereas one antibody bound to an epitope that did not include any of those residues.	Arginine	104-112	von Willebrand factor	Homo sapiens	51-54
1715119-7	1990	In spite of the cross-reactivity for binding to vWF, only the two antibodies whose epitopes included residues in the Arg-Gly-Asp sequence inhibited vWF interaction with GP IIb-IIIa.	Arginine	117-120	von Willebrand factor	Homo sapiens	148-151
2310429-2	1990	This disorder is associated with a G to A mutation in exon 26 of the apolipoprotein B (apo B) gene which creates a substitution of glutamine for arginine in the codon for amino acid 3500.	Arginine	145-153	apolipoprotein B	Homo sapiens	69-85
2105906-5	1990	The second results in an Arg----Cys substitution at a thrombin cleavage site.	Arginine	25-28	coagulation factor II, thrombin	Homo sapiens	54-62
2097094-4	1990	In contrast, NPY at 17 pmol/min reduced the plasma insulin response to both glucose (by 11%; p less than 0.001) and to arginine (by 26%; p less than 0.001).	Arginine	119-127	neuropeptide Y	Rattus norvegicus	13-16
33818064-5	2021	Molecular docking suggested that residues Trp-588, Ile-590, and Arg-592 of Munc13-1 are involved in ligand interactions.	Arginine	64-67	unc-13 homolog A	Mus musculus	75-83
2185237-5	1990	By replacing each of the three arginine (Arg) residues (Arg10P, Arg15P, and Arg20P) with Gln residues, partially active prorenins were produced, which exhibited significant but not full renin activity without trypsin activation.	Arginine	31-39	renin	Homo sapiens	123-128
2185237-5	1990	By replacing each of the three arginine (Arg) residues (Arg10P, Arg15P, and Arg20P) with Gln residues, partially active prorenins were produced, which exhibited significant but not full renin activity without trypsin activation.	Arginine	41-44	renin	Homo sapiens	123-128
2193150-8	1990	The migration-promoting effect of fibronectin can be specifically inhibited both in vivo and in vitro by antibodies to fibronectin, integrin receptors, or by peptides containing the Arg-Gly-Asp-Ser sequence.	Arginine	182-185	fibronectin 1	Homo sapiens	34-45
2250583-3	1990	Using the technique for site-specific mutagenesis, we tested whether the arginine residue at the 4th position in human IL-1 beta is essential for multiple biological activities.	Arginine	73-81	interleukin 1 beta	Homo sapiens	119-128
2403623-3	1990	Likewise, in isolated islets prepared from the glucose-infused rats, L-arginine or theophylline stimulated insulin release at a low ambient concentration of D-glucose, at variance with the situation found in islets removed from normal rats.	Arginine	69-79	insulin	Homo sapiens	107-114
21043983-4	1990	Binding of LDL by platelets was rapid and apparently mediated by recognition of positively charged arginine and lysine residues within the protein constituent (apoB) of LDL, findings previously reported as characteristics of LDL stimulation of platelet aggregation.	Arginine	99-107	apolipoprotein B	Homo sapiens	160-164
6241542-2	1984	The most active peptides are C5a and C5a des Arg generated by cleavage of the alpha-chain of native C5.	Arginine	45-48	complement C5a receptor 1	Homo sapiens	37-40
6241542-4	1984	Upon generation C5a is converted in serum and plasma to C5a des Arg with loss of the noxious anaphylatoxin activity.	Arginine	64-67	complement C5a receptor 1	Homo sapiens	16-19
6241542-4	1984	Upon generation C5a is converted in serum and plasma to C5a des Arg with loss of the noxious anaphylatoxin activity.	Arginine	64-67	complement C5a receptor 1	Homo sapiens	56-59
6241542-5	1984	C5a/C5a des Arg play important roles in host defenses against bacterial infections and possibly in the mediation of some pathologic lesions such as the leukocyte infiltration seen in the lungs during acute respiratory distress syndrome.	Arginine	12-15	complement C5a receptor 1	Homo sapiens	0-3
6241542-5	1984	C5a/C5a des Arg play important roles in host defenses against bacterial infections and possibly in the mediation of some pathologic lesions such as the leukocyte infiltration seen in the lungs during acute respiratory distress syndrome.	Arginine	12-15	complement C5a receptor 1	Homo sapiens	4-7
33818064-11	2021	This study shows that Trp-588, Ile-590, and Arg-592 are essential determinants for the activity of Munc13-1 and the effects of the three residues on the activity are ligand-dependent.	Arginine	44-47	unc-13 homolog A	Mus musculus	99-107
2187493-5	1990	Within the cancer group as a whole, there was no significant correlation with pathological grade or clinical stage of tumor but in one subgroup--follicular carcinomas--a significant association was noted between TGF-beta immunostaining and the presence of a specific mutation of the H-ras oncogene (codon 61, gln----arg).	Arginine	316-319	transforming growth factor beta 1	Homo sapiens	212-220
1695615-2	1990	In Caucasoids two amino acids, Tyr at position 26 and Arg at position 74 of HLA class II DR beta chains, have been found to be associated with the presence of TR81.	Arginine	54-57	major histocompatibility complex, class II, DR beta 1	Homo sapiens	76-79
1695615-3	1990	Recently, a variant of DRB1*03 identified in American Blacks has been shown to possess Arg at position 74 but Phe at position 26.	Arginine	87-90	major histocompatibility complex, class II, DR beta 1	Homo sapiens	23-27
2193150-9	1990	Neural crest cells recognize two major adhesion sites along fibronectin molecules; these are the Arg-Gly-Asp-Ser sequence located in the medial part of the molecule and the CS1 site situated in the alternatively spliced IIICS region.	Arginine	97-100	fibronectin 1	Homo sapiens	60-71
33972717-3	2021	In this study, we found that PRMT5 interacts with KLF5 and catalyzes the di-methylation of KLF5 at Arginine 57 (R57) in a methyltransferase activity-dependent manner in BLBC cells.	Arginine	99-107	protein arginine methyltransferase 5	Homo sapiens	29-34
33942982-13	2021	In conclusion, we revealed circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R.	Arginine	89-90	interleukin 6 receptor	Homo sapiens	127-132
33764612-1	2021	Protein arginine methyltransferase 6 (PRMT6) catalyses the asymmetric dimethylation of arginines on numerous substrate proteins within the human cell.	Arginine	87-96	protein arginine methyltransferase 6	Homo sapiens	0-36
33787218-3	2021	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	vascular endothelial growth factor A	Homo sapiens	78-114
33940558-3	2021	In response to DNA strand breaks, PARP1 covalently attaches ADP-ribose moieties to arginine, glutamate, aspartate, cysteine, lysine, and serine acceptor sites on both itself and other proteins.	Arginine	83-91	poly(ADP-ribose) polymerase 1	Homo sapiens	34-39
33787218-3	2021	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	vascular endothelial growth factor A	Homo sapiens	116-122
33761250-1	2021	Protein arginine methyltransferase 6 (PRMT6), a member of type I PRMT enzymes, catalyzes the monomethylation or asymmetric dimethylation of arginine residues.	Arginine	8-16	protein arginine methyltransferase 6	Homo sapiens	38-43
33764612-9	2021	We show that PRMT6 also has preference for glycine, but only in the position immediately following the target arginine.	Arginine	110-118	protein arginine methyltransferase 6	Homo sapiens	13-18
33764612-1	2021	Protein arginine methyltransferase 6 (PRMT6) catalyses the asymmetric dimethylation of arginines on numerous substrate proteins within the human cell.	Arginine	87-96	protein arginine methyltransferase 6	Homo sapiens	38-43
33764612-2	2021	In particular, PRMT6 methylates histone H3 arginine 2 (H3R2) which affects both gene repression and activation.	Arginine	43-51	protein arginine methyltransferase 6	Homo sapiens	15-20
33762328-3	2021	Here, we identified protein arginine methyltransferase 5 (PRMT5) as a direct binding partner of cGAS, and it catalyzed the arginine symmetrical dimethylation of cGAS at the Arg124 residue.	Arginine	28-36	cyclic GMP-AMP synthase	Mus musculus	96-100
33762328-3	2021	Here, we identified protein arginine methyltransferase 5 (PRMT5) as a direct binding partner of cGAS, and it catalyzed the arginine symmetrical dimethylation of cGAS at the Arg124 residue.	Arginine	28-36	cyclic GMP-AMP synthase	Mus musculus	161-165
33815657-9	2021	In vitro, L-Arginine induced the expression of a key regulator of mitochondrial biogenesis (PGC1alpha) and genes encoding for complex I and increased the production of nitric oxide and the maximal oxygen consumption rate.	Arginine	10-20	PPARG coactivator 1 alpha	Homo sapiens	92-101
33800773-7	2021	Survival analysis showed an accelerated disease progression of individuals infected with HIV-1 carrying arginine or asparagine at position 8 or 157 in Nef, respectively, or the R178G Nef mutation.	Arginine	104-112	S100 calcium binding protein B	Homo sapiens	151-154
33767671-6	2021	Results: Among women included in the analysis, 51.3% of them needed insulin therapy for glycemic control: 61.8% D, 28.3% combined D and R, and 9.9% R alone.	Arginine	0-1	insulin	Homo sapiens	68-75
33767671-6	2021	Results: Among women included in the analysis, 51.3% of them needed insulin therapy for glycemic control: 61.8% D, 28.3% combined D and R, and 9.9% R alone.	Arginine	136-137	insulin	Homo sapiens	68-75
33768972-2	2021	Of the nine mammalian PRMTs, PRMT5 is the primary enzyme responsible for the deposition of symmetric arginine methylation marks in cells.	Arginine	101-109	protein arginine methyltransferase 5	Homo sapiens	29-34
33033064-6	2021	Insulin secretion/insulin resistance (disposition) index declined by 60% (2nd clamp step) and by 62% following arginine (both p<0.005) following 72 hour glucose infusion.	Arginine	111-119	insulin	Homo sapiens	0-7
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	BCL2 like 1	Homo sapiens	66-72
30576235-0	2019	Triple arginine residues in the proximal C-terminus of TREK K+ channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate.	Arginine	7-15	potassium two pore domain channel subfamily K member 2	Homo sapiens	55-59
33817163-3	2019	The development of oxidative-nitrative stress in peripheral blood cells during DM can be prevented by agmatine, an endogenous metabolite of L-arginine, which is a nitric oxide synthase (NOS) inhibitor, and possesses hypoglycemic properties.	Arginine	140-150	nitric oxide synthase 2	Homo sapiens	163-184
11502203-7	2001	The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues.	Arginine	155-158	plasminogen activator, urokinase	Homo sapiens	56-59
18561519-5	2008	RESULTS: After 1 hr of reperfusion serum NO concentration was elevated in IR1 and L-Arg(IR1) groups compared with group C but not in L-NAME(IR1) and Allo(IR1) group.	Arginine	82-87	nischarin	Rattus norvegicus	88-91
18561519-5	2008	RESULTS: After 1 hr of reperfusion serum NO concentration was elevated in IR1 and L-Arg(IR1) groups compared with group C but not in L-NAME(IR1) and Allo(IR1) group.	Arginine	82-87	nischarin	Rattus norvegicus	88-91
18561519-5	2008	RESULTS: After 1 hr of reperfusion serum NO concentration was elevated in IR1 and L-Arg(IR1) groups compared with group C but not in L-NAME(IR1) and Allo(IR1) group.	Arginine	82-87	nischarin	Rattus norvegicus	88-91
30354839-4	2018	PRMT1 catalyzes the arginine methylation of Fused in Sarcoma (FUS), an RNA-binding protein that interacts with RALY.	Arginine	20-28	FUS RNA binding protein	Homo sapiens	44-60
30354839-4	2018	PRMT1 catalyzes the arginine methylation of Fused in Sarcoma (FUS), an RNA-binding protein that interacts with RALY.	Arginine	20-28	FUS RNA binding protein	Homo sapiens	62-65
30354839-4	2018	PRMT1 catalyzes the arginine methylation of Fused in Sarcoma (FUS), an RNA-binding protein that interacts with RALY.	Arginine	20-28	RALY heterogeneous nuclear ribonucleoprotein	Homo sapiens	111-115
29261001-5	2018	Upon N-end rule interaction with the Nt-Arg of arginylated HSPA5 (R-HSPA5), SQSTM1 undergoes self-polymerization via disulfide bonds of Cys residues including Cys113, facilitating cargo collection.	Arginine	40-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	59-64
29261001-5	2018	Upon N-end rule interaction with the Nt-Arg of arginylated HSPA5 (R-HSPA5), SQSTM1 undergoes self-polymerization via disulfide bonds of Cys residues including Cys113, facilitating cargo collection.	Arginine	40-43	heat shock protein family A (Hsp70) member 5	Homo sapiens	66-73
11502203-7	2001	The ability of these antibodies to block the binding of uPA to polyanions correlated with a reduced uPA-polyanion affinity after substitution of the three Arg residues.	Arginine	155-158	plasminogen activator, urokinase	Homo sapiens	100-103
8652826-5	1996	That YAC-1 killing resulted, in part, from the production of NO was confirmed by the significant protection of cell lysis in L-arginine-depleted medium and by approximately 30 % attenuation of cell lysis and DNA fragmentation by an inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (L-NAME) in a culture medium containing 1 mmol/L L-arginine.	Arginine	125-135	ADP-ribosyltransferase 1	Mus musculus	5-10
12030603-10	2002	Serum IGF-I levels in PES patients with blunted GH responses to provocative tests were significantly (p&lt;0.001) lower in PES patients with normal GH responses, and a positive correlation was observed between IGF-I levels and serum GH peak concentrations after GHRH+ARG.	Arginine	267-270	insulin like growth factor 1	Homo sapiens	6-11
12030603-10	2002	Serum IGF-I levels in PES patients with blunted GH responses to provocative tests were significantly (p&lt;0.001) lower in PES patients with normal GH responses, and a positive correlation was observed between IGF-I levels and serum GH peak concentrations after GHRH+ARG.	Arginine	267-270	insulin like growth factor 1	Homo sapiens	210-215
8652826-5	1996	That YAC-1 killing resulted, in part, from the production of NO was confirmed by the significant protection of cell lysis in L-arginine-depleted medium and by approximately 30 % attenuation of cell lysis and DNA fragmentation by an inhibitor of NO synthase, NG-nitro-L-arginine methyl ester (L-NAME) in a culture medium containing 1 mmol/L L-arginine.	Arginine	267-277	ADP-ribosyltransferase 1	Mus musculus	5-10
7925354-1	1994	Two deletion variants of chicken cystatin were produced after cassette mutagenesis of the recombinant Arg-Glu-Phe-[Met1, Ile29, Leu89]-chicken egg white cystatin gene in Escherichia coli.	Arginine	102-105	cystatin C	Gallus gallus	33-41
8070361-2	1994	The rat PACE4 sequence has the Asp-His-Ser catalytic site triad, an Arg-Gly-Asp potential integrin binding site, and three potential sites for N-linked glycosylation.	Arginine	68-71	proprotein convertase subtilisin/kexin type 6	Rattus norvegicus	8-13
7683862-13	1993	Chemical modification with group-specific reagents revealed that the integrity of carboxyl groups of the sarcolectin-binding protein and of lysine/arginine groups of sarcolectin are primarily important to maintain binding capacity.	Arginine	147-155	keratin 7	Homo sapiens	166-177
34380107-7	2022	Results showed a mixed type of inhibition behavior and, the docking molecular analyzes suggest that the inhibition AChE occurred due to the basic amino acids, mainly by arginine.	Arginine	169-177	acetylcholinesterase (Cartwright blood group)	Homo sapiens	115-119
34954298-4	2022	Agarose native gel electrophoresis showed that aggregation of bovine serum albumin (BSA) induced by heating was slightly reduced by NaCl and ArgHCl.	Arginine	141-147	albumin	Homo sapiens	69-82
34923393-6	2022	We predict that the two positively charged arginine residues (Arg409 and Arg413) in the exosite-2 region, the beta- and gamma-insertion loops of thrombin play an important structural role in the initial activating complex between fXI and thrombin.	Arginine	43-51	coagulation factor II, thrombin	Homo sapiens	145-153
34923393-6	2022	We predict that the two positively charged arginine residues (Arg409 and Arg413) in the exosite-2 region, the beta- and gamma-insertion loops of thrombin play an important structural role in the initial activating complex between fXI and thrombin.	Arginine	43-51	coagulation factor II, thrombin	Homo sapiens	238-246
34844806-3	2022	The adsorption capacity of MP20 (20-day UV-aged PS-MPs) towards E. coli (harboring plasmid-borne blaTEM-1), plasmid pET29 (harboring blaNDM-1) and phage lambda (carrying the aphA1 ARG) increased by 6.6-, 5.2- and 8.3-fold, respectively, relative to pristine PS-MPs (MP0), due to increased specific surface area and affinity for these ARG vectors.	Arginine	334-337	lens intrinsic membrane protein 2	Homo sapiens	27-31
34844806-3	2022	The adsorption capacity of MP20 (20-day UV-aged PS-MPs) towards E. coli (harboring plasmid-borne blaTEM-1), plasmid pET29 (harboring blaNDM-1) and phage lambda (carrying the aphA1 ARG) increased by 6.6-, 5.2- and 8.3-fold, respectively, relative to pristine PS-MPs (MP0), due to increased specific surface area and affinity for these ARG vectors.	Arginine	334-337	beta-lactamase	Escherichia coli	97-105
34844806-5	2022	Accordingly, MP20 enhanced ARG transfer frequency from E. coli, plasmid pET29 and phage lambda (relative to MP0) by 1.3-, 4.7- and 3.5-fold, respectively.	Arginine	27-30	lens intrinsic membrane protein 2	Homo sapiens	13-17
34730397-0	2022	Role of the arginine cluster in the disordered domain of Herpes Simplex Virus 1 UL34 for the recruitment of ESCRT-III for viral primary envelopment.	Arginine	12-20	nuclear egress membrane protein	Human alphaherpesvirus 1	80-84
34730397-3	2022	In this study, we identified a cluster of six arginine residues in the disordered domain of UL34 as a minimal region required for the interaction with ALIX as well as the recruitment of ALIX and an ESCRT-III protein CHMP4B to the INM in HSV-1-infected cells.	Arginine	46-54	nuclear egress membrane protein	Human alphaherpesvirus 1	92-96
34730397-5	2022	We also showed that the effect of the arginine cluster in UL34 on HSV-1 replication was dependent primarily on ALIX.	Arginine	38-46	nuclear egress membrane protein	Human alphaherpesvirus 1	58-62
34730397-6	2022	These results indicated that the arginine cluster in the disordered domain of UL34 was required for the interaction with ALIX and the recruitment of ESCRT-III machinery to the INM to promote primary envelopment.	Arginine	33-41	nuclear egress membrane protein	Human alphaherpesvirus 1	78-82
34730397-10	2022	In this study, we present data suggesting that the arginine cluster in the disordered domain of HSV-1 UL34 mediates the interaction with ALIX, thereby leading to the recruitment of ESCRT-III machinery to the INM for efficient primary envelopment.	Arginine	51-59	nuclear egress membrane protein	Human alphaherpesvirus 1	102-106
34817806-5	2022	Next to TP53 and PTEN, FBXW7 was reported with the highest percentage of arginine substitution among mutations related to cancer.	Arginine	73-81	tumor protein p53	Homo sapiens	8-12
34817806-5	2022	Next to TP53 and PTEN, FBXW7 was reported with the highest percentage of arginine substitution among mutations related to cancer.	Arginine	73-81	F-box and WD repeat domain containing 7	Homo sapiens	23-28
34841717-2	2022	Preclinical data demonstrated that depletion of arginine by PEGylated arginine deiminase (ADI-PEG 20) enhanced liposomal doxorubicin (PLD) cytotoxicity in cancer cells with argininosuccinate synthase 1 (ASS1) deficiency.	Arginine	48-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	134-137
34794114-1	2022	Protein arginine N-methyltransferase 5 (PRMT5) enzyme is one of the eight canonical PRMTs, classified as a type II PRMT, induces arginine monomethylation and symmetric dimethylation.	Arginine	129-137	protein arginine methyltransferase 5	Homo sapiens	0-38
34794114-1	2022	Protein arginine N-methyltransferase 5 (PRMT5) enzyme is one of the eight canonical PRMTs, classified as a type II PRMT, induces arginine monomethylation and symmetric dimethylation.	Arginine	129-137	protein arginine methyltransferase 5	Homo sapiens	40-45
34686989-11	2022	Furthermore, our findings proposed that elevated vulnerability of Vitiligo patients due to DRB4*01:01 and DRB1*07:01 alleles maybe is correlated with the presence of amino acid Arginine at position 71 at pocket 4 on the antigen-binding site of the HLA-DRB1 receptor.	Arginine	177-185	major histocompatibility complex, class II, DR beta 1	Homo sapiens	106-110
34418530-0	2022	Diagnosing growth hormone deficiency - Can a combined arginine and clonidine stimulation test replace two separate tests?	Arginine	54-62	growth hormone 1	Homo sapiens	11-25
34773872-6	2022	Energy decomposition exhibited that the Gibbs free energies of the AChE-(R)-/(S)-pyraclofos were DeltaG  = -37.4/-30.2 kJ mol-1, respectively, and the disparity comes from the electrostatic energy during the stereoselective neurochemical reactions.	Arginine	72-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
34918843-3	2022	Two contrasting metabolic enzymes that use arginine as a substrate, inducible nitric oxide synthase (iNOS), and arginase-1 (Arg-1), have been identified as M1-MPhi and M2-MPhi markers, respectively.	Arginine	43-51	nitric oxide synthase 2, inducible	Mus musculus	68-99
34943098-8	2021	Supplementation with 1.0% L-arginine significantly increased (p < 0.05) ADG, the activities of CAT, SOD, and GPx, intestinal villus height and mRNA abundances of ZO-1 (2-fold) in the jejunum of LBW piglets, but not in NBW piglets.	Arginine	26-36	catalase	Homo sapiens	95-98
34957557-0	2021	L-Arginine protects cementoblasts against hypoxia-induced apoptosis through Sirt1-enhanced autophagy.	Arginine	0-10	sirtuin 1	Rattus norvegicus	76-81
34957557-5	2021	To investigate the role of Sirtuin 1 (Sirt1) and autophagy in L-arg resistance to cementoblast apoptosis and root absorption, resveratrol and EX527 were used to activate or inhibit Sirt1, and chloroquine (CQ) was used to inhibit autophagy.	Arginine	62-67	sirtuin 1	Rattus norvegicus	27-36
34957557-13	2021	Similarly, L-arg upregulated Sirt1, which activated autophagy in the root resorption model, and less root resorption was observed in the Sirt1 activation group.	Arginine	11-16	sirtuin 1	Rattus norvegicus	29-34
34957557-14	2021	CONCLUSION(S): : L-arg reduced cementoblast apoptosis in hypoxia and reduced root resorption induced by loading force in rats, which may be partly mediated by Sirt1-enhanced autophagy.	Arginine	17-22	sirtuin 1	Rattus norvegicus	159-164
34918843-3	2022	Two contrasting metabolic enzymes that use arginine as a substrate, inducible nitric oxide synthase (iNOS), and arginase-1 (Arg-1), have been identified as M1-MPhi and M2-MPhi markers, respectively.	Arginine	43-51	nitric oxide synthase 2, inducible	Mus musculus	101-105
34888656-7	2022	Using a combination of in vitro methylation and cell-based experiments we identified PRMT4 (CARM1) and PRMT6 as major enzymes methylating HTT at specific arginines.	Arginine	154-163	protein arginine methyltransferase 6	Homo sapiens	103-108
34906317-3	2021	use synthetic biology to alter intratumoral arginine levels via engineered bacteria, leading to improved responsiveness to anti-PD-L1 checkpoint blockade in a murine model of cancer.	Arginine	44-52	CD274 antigen	Mus musculus	128-133
34893694-6	2021	CECs differentiated from peripheral blood mononuclear cells potently suppress T-cell activation, proliferation, and IFN-gamma production in an ARG- and ROS-dependent manner.	Arginine	143-146	interferon gamma	Homo sapiens	116-125
34943060-0	2021	l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.	Arginine	0-10	thymoma viral proto-oncogene 1	Mus musculus	86-89
34943060-10	2021	Our findings revealed that l-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.	Arginine	27-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
34943060-0	2021	l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.	Arginine	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
34943060-6	2021	Furthermore, l-Arg improved antioxidant-related enzymes" activities; increased antioxidant ability via Akt-Nrf2 signaling pathway; maintained the mitochondrial membrane potential (MMP); and enhanced FOXO3a expression, leading to a decrease in the mitochondrial-associated apoptotic proteins.	Arginine	13-18	thymoma viral proto-oncogene 1	Mus musculus	103-106
34943060-6	2021	Furthermore, l-Arg improved antioxidant-related enzymes" activities; increased antioxidant ability via Akt-Nrf2 signaling pathway; maintained the mitochondrial membrane potential (MMP); and enhanced FOXO3a expression, leading to a decrease in the mitochondrial-associated apoptotic proteins.	Arginine	13-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
34943060-10	2021	Our findings revealed that l-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.	Arginine	27-32	thymoma viral proto-oncogene 1	Mus musculus	123-126
34944251-3	2021	Skeletal muscle from piglets born from sows from ARG group had greater mRNA expression of MYOD (p = 0.043) and MYOG (p <= 0.01), and tended to present greater mRNA expression (p = 0.06) of IGF-2 gene compared to those born from CON sows.	Arginine	49-52	myogenic differentiation 1	Homo sapiens	90-94
34870594-6	2021	Here we identify a hydrogen bond between the side chain of arginine 117 and the backbone carbonyl group of glutamate 1124 in the cryo-electronmicroscopic structure of phosphorylated, ATP-bound CFTR.	Arginine	59-67	CF transmembrane conductance regulator	Homo sapiens	193-197
34517782-5	2021	Besides, miR-148 improved the immune dysfunction induced by MI/R through increasing the number of interleukin (IL)-10+ cells and reducing the number of inducible nitric oxide synthase (iNOS)+ cells.	Arginine	63-64	nitric oxide synthase 2	Rattus norvegicus	152-183
34855201-7	2022	Molecular modeling analysis predicted that trimethoprim directly binds to the arginine-174 pocket of Snail protein.	Arginine	78-86	snail family transcriptional repressor 1	Homo sapiens	101-106
34862383-4	2021	Among the 20 amino acids, deprivation of glutamine, arginine, methionine, and lysine induced AKT activation.	Arginine	52-60	AKT serine/threonine kinase 1	Homo sapiens	93-96
34900520-13	2021	When coexpressing miR-21-5p mimic and CPEB3 in the cells, the protective effects of miR-21-5p under H/R were reversed (all P < 0.05), and the activation of the EGFR/PI3K/AKT pathway was also inhibited (all P < 0.05).	Arginine	102-103	cytoplasmic polyadenylation element binding protein 3	Mus musculus	38-43
34900520-14	2021	Conclusion: This study showed that miR-21-5p may regulate the EGFR/PI3K/AKT signaling pathway by targeting CPEB3 to reduce H/R-induced cell damage and apoptosis.	Arginine	125-126	thymoma viral proto-oncogene 1	Mus musculus	72-75
34900520-14	2021	Conclusion: This study showed that miR-21-5p may regulate the EGFR/PI3K/AKT signaling pathway by targeting CPEB3 to reduce H/R-induced cell damage and apoptosis.	Arginine	125-126	cytoplasmic polyadenylation element binding protein 3	Mus musculus	107-112
34738040-5	2021	The interleukin (IL)-6 and IL-1 levels in fetal blood and liver tissue as well as the myeloid differentiation primary response 88 (MyD88), transforming growth factor beta (TGFbeta), and nuclear factor kappa B (NF-kappaB) mRNA levels in the fetal liver were decreased (P < 0.05) by the NCG or RP-Arg supplementation compared to the RES treatment.	Arginine	295-298	tumor necrosis factor	Homo sapiens	139-170
34738040-5	2021	The interleukin (IL)-6 and IL-1 levels in fetal blood and liver tissue as well as the myeloid differentiation primary response 88 (MyD88), transforming growth factor beta (TGFbeta), and nuclear factor kappa B (NF-kappaB) mRNA levels in the fetal liver were decreased (P < 0.05) by the NCG or RP-Arg supplementation compared to the RES treatment.	Arginine	295-298	nuclear factor kappa B subunit 1	Homo sapiens	186-208
34738040-6	2021	Similarly, the toll-like receptor (TLR)-4, MyD88, TGFbeta, and p-c-Jun N-terminal kinase (JNK) protein levels in the fetal liver were reduced (P < 0.05) in the NCG and RP-Arg -supplemented groups compared to the RES group.	Arginine	171-174	mitogen-activated protein kinase 8	Homo sapiens	63-88
34738040-6	2021	Similarly, the toll-like receptor (TLR)-4, MyD88, TGFbeta, and p-c-Jun N-terminal kinase (JNK) protein levels in the fetal liver were reduced (P < 0.05) in the NCG and RP-Arg -supplemented groups compared to the RES group.	Arginine	171-174	mitogen-activated protein kinase 8	Homo sapiens	90-93
34738040-7	2021	These results showed that dietary supplementation of RP-Arg or NCG to underfed pregnant ewes could protect against IUGR fetal hepatic inflammation via improving lipid metabolism, down-regulating the TLR-4 and the inflammatory JNK and NF-kappaB signaling pathways, and decreasing cytokine production in ovine fetal blood and liver tissue.	Arginine	56-59	mitogen-activated protein kinase 8	Homo sapiens	226-229
34738040-7	2021	These results showed that dietary supplementation of RP-Arg or NCG to underfed pregnant ewes could protect against IUGR fetal hepatic inflammation via improving lipid metabolism, down-regulating the TLR-4 and the inflammatory JNK and NF-kappaB signaling pathways, and decreasing cytokine production in ovine fetal blood and liver tissue.	Arginine	56-59	nuclear factor kappa B subunit 1	Homo sapiens	234-243
34738042-7	2021	Relative mRNA expression levels of Ca2+ channels including the type 1 ryanodine receptor (RyR1) and voltage-gated Ca2+ channel (Cav1.1) were upregulated by 1.2 mmol/L arginine during 2-d myogenic induction (P < 0.01).	Arginine	167-175	ryanodine receptor 1, skeletal muscle	Mus musculus	63-88
34738042-7	2021	Relative mRNA expression levels of Ca2+ channels including the type 1 ryanodine receptor (RyR1) and voltage-gated Ca2+ channel (Cav1.1) were upregulated by 1.2 mmol/L arginine during 2-d myogenic induction (P < 0.01).	Arginine	167-175	ryanodine receptor 1, skeletal muscle	Mus musculus	90-94
34517782-5	2021	Besides, miR-148 improved the immune dysfunction induced by MI/R through increasing the number of interleukin (IL)-10+ cells and reducing the number of inducible nitric oxide synthase (iNOS)+ cells.	Arginine	63-64	nitric oxide synthase 2	Rattus norvegicus	185-189
34517782-6	2021	In addition, miR-148 relieved the apoptosis of cardiomyocytes induced by MI/R through inhibiting the expression of Bax and elevating the expression of Bcl-2.	Arginine	76-77	BCL2, apoptosis regulator	Rattus norvegicus	151-156
34619493-1	2021	The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine methyltransferase catalyzes the mono- and symmetric dimethylation of arginine residues in both histone and non-histone proteins.	Arginine	148-156	protein arginine methyltransferase 5	Homo sapiens	4-40
34634559-7	2021	L-arginine treatment reduced the expression of components of the nuclear factor E2-related factor 2 (Nrf2) signaling pathway and the downstream protein heme oxygenase-1 (HO-1) in mice, whereas Gal increased their expression.	Arginine	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-99
34634559-7	2021	L-arginine treatment reduced the expression of components of the nuclear factor E2-related factor 2 (Nrf2) signaling pathway and the downstream protein heme oxygenase-1 (HO-1) in mice, whereas Gal increased their expression.	Arginine	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
34634559-7	2021	L-arginine treatment reduced the expression of components of the nuclear factor E2-related factor 2 (Nrf2) signaling pathway and the downstream protein heme oxygenase-1 (HO-1) in mice, whereas Gal increased their expression.	Arginine	0-10	heme oxygenase 1	Mus musculus	152-168
34634559-7	2021	L-arginine treatment reduced the expression of components of the nuclear factor E2-related factor 2 (Nrf2) signaling pathway and the downstream protein heme oxygenase-1 (HO-1) in mice, whereas Gal increased their expression.	Arginine	0-10	heme oxygenase 1	Mus musculus	170-174
34634559-9	2021	Taken together, our results imply that Gal has protective effects in L-arginine-induced SAP that are induced by the upregulation of the Nrf2/HO-1 pathway, which has anti-inflammatory and antioxidant effects.	Arginine	69-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
34634559-9	2021	Taken together, our results imply that Gal has protective effects in L-arginine-induced SAP that are induced by the upregulation of the Nrf2/HO-1 pathway, which has anti-inflammatory and antioxidant effects.	Arginine	69-79	heme oxygenase 1	Mus musculus	141-145
34661323-4	2021	Toward this goal, the current study generated a mouse line in which lysine 13, which is critical for the nuclear localization of PTEN, is changed to arginine in the lipid-binding domain using the CRISPR-Ca9 gene-editing system.	Arginine	149-157	phosphatase and tensin homolog	Mus musculus	129-133
34279997-9	2021	Besides, the nonsynonymous mutations existed in four ARGs in different strains, including CatB (Pro165Ser, Gly208Asp), VmeA (Ile313Thr), VmeC (Glu329Ala), and VmeD (Asn205Ser).	Arginine	53-57	multidrug efflux RND transporter permease subunit VmeD	Vibrio parahaemolyticus	159-163
34272483-0	2021	Caffey disease is associated with distinct arginine to cysteine substitutions in the proalpha1(I) chain of type I procollagen.	Arginine	43-51	collagen type I alpha 2 chain	Homo sapiens	107-125
34272483-10	2021	CONCLUSION: The discovery of this novel pathogenic variant expands the limited spectrum of arginine to cysteine substitutions in type I procollagen.	Arginine	91-99	collagen type I alpha 2 chain	Homo sapiens	129-147
34619493-1	2021	The protein arginine methyltransferase 5 (PRMT5) as the major type II arginine methyltransferase catalyzes the mono- and symmetric dimethylation of arginine residues in both histone and non-histone proteins.	Arginine	148-156	protein arginine methyltransferase 5	Homo sapiens	42-47
34121195-6	2021	Recent and compelling evidence has reinforced that eNOS regulation results from a complex network of processes, with novel data concerning mechanisms such as mechano-sensing, epigenetic, posttranslational modifications, and the expression of NO- and l-arginine-related pathways.	Arginine	250-260	nitric oxide synthase 3	Homo sapiens	51-55
34737042-10	2021	Our results suggested: (1) NO and dopamine D2 receptor mechanisms affect anxiety and memory in PD mice; (2) L-NAME reversed anxiogenic and memory-improvement effect induced by sulpiride; (3) Anxiolytic and amnesic effects induced by quinpirole reversed by L-arginine; (4) There is a synergistic effect between dopamine D2 receptor and NO systems on the modulation of anxiety and memory.	Arginine	256-266	dopamine receptor D2	Mus musculus	34-54
34737042-10	2021	Our results suggested: (1) NO and dopamine D2 receptor mechanisms affect anxiety and memory in PD mice; (2) L-NAME reversed anxiogenic and memory-improvement effect induced by sulpiride; (3) Anxiolytic and amnesic effects induced by quinpirole reversed by L-arginine; (4) There is a synergistic effect between dopamine D2 receptor and NO systems on the modulation of anxiety and memory.	Arginine	256-266	dopamine receptor D2	Mus musculus	310-330
34784468-1	2021	Hindered rotation about an sp2 C-N bond is known to occur in arginine (Arg), asparagine (Asn), and glutamine (Gln) side chains of proteins.	Arginine	61-69	Sp2 transcription factor	Homo sapiens	27-30
34534716-1	2021	Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus.	Arginine	128-136	neuropeptide FF-amide peptide precursor	Homo sapiens	0-15
34534716-1	2021	Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus.	Arginine	128-136	neuropeptide FF-amide peptide precursor	Homo sapiens	17-21
34181038-0	2021	Acute Effects of Vasopressin Arginine Infusion in Children with Congenital Heart Disease: Higher Blood Pressure Does Not Equal Improved Systemic Oxygen Delivery.	Arginine	29-37	arginine vasopressin	Homo sapiens	17-28
34597810-1	2021	Synergistic physiologic mechanisms involving the renin-angiotensin system (RAS), the sympathetic nervous system, and the arginine-vasopressin system play an integral role in blood pressure homeostasis.	Arginine	121-129	arginine vasopressin	Homo sapiens	130-141
34837556-3	2022	In this study, BAIBA (100 mg/kg/day) significantly attenuated SSHT via increased nitric oxide (NO) content in the renal medulla, and it induced a significant increase in NO synthesis substrates (L-arginine and malic acid) in the renal medulla.	Arginine	195-205	alanine--glyoxylate aminotransferase 2	Homo sapiens	15-20
34784468-1	2021	Hindered rotation about an sp2 C-N bond is known to occur in arginine (Arg), asparagine (Asn), and glutamine (Gln) side chains of proteins.	Arginine	71-74	Sp2 transcription factor	Homo sapiens	27-30
34946802-0	2021	Beyond Sector Retinitis Pigmentosa: Expanding the Phenotype and Natural History of the Rhodopsin Gene Codon 106 Mutation (Gly-to-Arg) in Autosomal Dominant Retinitis Pigmentosa.	Arginine	129-132	rhodopsin	Homo sapiens	87-96
34783301-6	2021	The development of AIC was significantly related to Arg/Arg of p53 protein gene (OR = 2.972; p = 0.001), T/T of NOS3 gene (OR = 3.059, p = 0.018), T/T of NADPH oxidase gene (OR = 2.753, p = 0.008), and C/C of GPX1 (OR = 2.345; p = 0.007).	Arginine	52-55	tumor protein p53	Homo sapiens	63-66
34867480-7	2021	Interestingly, hypoxia or DMOG upregulates transforming growth factor beta1 (TGFbeta1) levels and collagens Ialpha1, which is prevented by Arg-II silencing, while TGFbeta1-induced collagen Ialpha1 expression is not affected by Arg-II silencing.	Arginine	139-142	histocompatibility 2, class II antigen A, alpha	Mus musculus	108-115
34792662-5	2021	RESULTS: Widespread alterations were evident in alanine, aspartate, glutamate, and arginine metabolism in Ndufs4 KO mice; while brain-region specific metabolic signatures include the accumulation of branched-chain amino acids, proline, and glycolytic intermediates.	Arginine	83-91	NADH:ubiquinone oxidoreductase core subunit S4	Mus musculus	106-112
34739238-2	2021	The observed DBSs are bound to the spin-orbit excited I(2P1/2) level of the neutral Arg I complex in zwitterionic conformations and identified based on the resonant enhancement due to spin-orbit electronic autodetachment from the I(2P1/2) DBS to the I(2P3/2) neutral ground state.	Arginine	84-87	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	56-61
34739238-2	2021	The observed DBSs are bound to the spin-orbit excited I(2P1/2) level of the neutral Arg I complex in zwitterionic conformations and identified based on the resonant enhancement due to spin-orbit electronic autodetachment from the I(2P1/2) DBS to the I(2P3/2) neutral ground state.	Arginine	84-87	NADH:ubiquinone oxidoreductase complex assembly factor 3	Homo sapiens	232-237
34783301-6	2021	The development of AIC was significantly related to Arg/Arg of p53 protein gene (OR = 2.972; p = 0.001), T/T of NOS3 gene (OR = 3.059, p = 0.018), T/T of NADPH oxidase gene (OR = 2.753, p = 0.008), and C/C of GPX1 (OR = 2.345; p = 0.007).	Arginine	56-59	tumor protein p53	Homo sapiens	63-66
34831346-0	2021	L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation.	Arginine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	68-72
34339793-14	2021	We also observed that DNJ, DAB, FAG, and ARG markedly downregulated IL-6 and TNF-alpha cytokine levels, while APS did not have an obvious effect.	Arginine	41-44	interleukin 6	Mus musculus	68-72
34339793-14	2021	We also observed that DNJ, DAB, FAG, and ARG markedly downregulated IL-6 and TNF-alpha cytokine levels, while APS did not have an obvious effect.	Arginine	41-44	tumor necrosis factor	Mus musculus	77-86
34780577-4	2021	An archetypal contact between a negatively charged SH3 residue and a highly conserved arginine in Nef (Arg77) plays a key role here.	Arginine	86-94	S100 calcium binding protein B	Homo sapiens	98-101
34831346-7	2021	Accordingly, provision of a positive nutrient signal by L-arginine supplementation partially restored mTOR activity and ameliorated the cytopathological abnormalities.	Arginine	56-66	mechanistic target of rapamycin kinase	Homo sapiens	102-106
34769369-1	2021	Competition for the amino acid arginine by endothelial nitric-oxide synthase (NOS3) and (pro-)inflammatory NO-synthase (NOS2) during endotoxemia appears essential in the derangement of the microcirculatory flow.	Arginine	31-39	nitric oxide synthase 2, inducible	Mus musculus	120-124
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	MAX interactor 1, dimerization protein	Homo sapiens	58-62
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	NFKB inhibitor alpha	Homo sapiens	64-69
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	71-77
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	plasminogen activator, urokinase	Homo sapiens	82-86
34606757-3	2021	Nitric oxide ( NO) is produced at oxidation of arginine by nitric oxide synthase (NOS) or at reduction of nitrites by diverse reductases.	Arginine	47-55	nitric oxide synthase 2	Homo sapiens	59-80
34731213-7	2021	Amino acids arginine, tyrosine, glutamic acid, tryptophan and asparagine also showed moderate COX-1 and COX-2 inhibition at the same concentration.	Arginine	12-20	cytochrome c oxidase subunit I	Petromyzon marinus	94-99
34407320-13	2021	Inhibition of the Nrf2/HO-1 pathway reversed the protective effect of ICA on H/R-induced ferroptosis.	Arginine	79-80	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-22
34583098-10	2021	Arginine methylation of TLR4 on R812 or PRMT2 enhanced interferon-beta (IFN-beta) production.	Arginine	0-8	IFN1@	Homo sapiens	72-80
34358365-3	2021	METHODS: Prognostic ARG candidates were identified by univariate and multivariate Cox regression analysis in the training dataset (TCGA-HNSC) and incorporated into a 3-ARGs (EGFR, FADD, PARK2) prognostic signature which was further verified in two independent validation cohorts (GSE41613 and GSE42743).	Arginine	20-23	epidermal growth factor receptor	Homo sapiens	174-178
34583098-0	2021	Arginine methylation by PRMT2 promotes IFN-beta production through TLR4/IRF3 signaling pathway.	Arginine	0-8	IFN1@	Homo sapiens	39-47
34583098-11	2021	Our study reveals a critical role for PRMT2 and protein arginine methylation in the enhancement of IFN-beta production via TLR4/IRF3 signaling pathway and may provide a therapeutic strategy to control endotoxemia.	Arginine	56-64	IFN1@	Homo sapiens	99-107
34679660-0	2021	Saccharomyces cerevisiae Rhodanese RDL2 Uses the Arg Residue of the Active-Site Loop for Thiosulfate Decomposition.	Arginine	49-52	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	35-39
34716181-1	2021	Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine.	Arginine	114-122	protein arginine methyltransferase 5	Homo sapiens	0-43
34738012-0	2021	Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.	Arginine	32-40	cold inducible RNA binding protein	Homo sapiens	26-31
34738012-8	2021	Furthermore, we uncovered that arginine methylation of the CIRBP RG/RGG region regulates in vitro phosphorylation by SRPK1.	Arginine	31-39	cold inducible RNA binding protein	Homo sapiens	59-64
34667218-10	2021	We conclude that inflammatory cells in blood and heart consume arginine and probably homoarginine via arginase 1 and inducible NO synthase and release ornithine and citrulline.	Arginine	63-71	nitric oxide synthase 2	Rattus norvegicus	117-138
34692742-6	2021	The relative mRNA expressions of mTOR and 4E-BP1 were up-regulated and accompanied by higher contents of Mucin-2 in the Arg group (p < 0.05).	Arginine	120-123	mechanistic target of rapamycin	Gallus gallus	33-37
34692742-6	2021	The relative mRNA expressions of mTOR and 4E-BP1 were up-regulated and accompanied by higher contents of Mucin-2 in the Arg group (p < 0.05).	Arginine	120-123	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	105-112
34301764-7	2021	Overall, these results demonstrate how arginine-metabolizing myeloid cells conspire with pathogenic CD4+ T cells to create permissive conditions for tumor formation, suggesting that these pro-tumorigenic pathways could be disabled by targeting myeloid arginine metabolism.	Arginine	39-47	CD4 molecule	Homo sapiens	100-103
34301764-7	2021	Overall, these results demonstrate how arginine-metabolizing myeloid cells conspire with pathogenic CD4+ T cells to create permissive conditions for tumor formation, suggesting that these pro-tumorigenic pathways could be disabled by targeting myeloid arginine metabolism.	Arginine	252-260	CD4 molecule	Homo sapiens	100-103
34428455-10	2021	We hypothesize that tumor-derived disruptions in Nitric Oxide Synthase (NOS)2-regulated arginine catabolism impair differentiation of MuSCs.	Arginine	88-96	nitric oxide synthase 2	Homo sapiens	72-77
34175655-5	2021	Recent studies identified cut-off values of 2.6 pmol/L for baseline copeptin and of 4.9 and 3.8 pmol/L for hypertonic saline infusion and arginine infusion stimulated copeptin, respectively, for the diagnosis of DI in patients with polyuria-polydipsia syndrome.	Arginine	138-146	arginine vasopressin	Homo sapiens	167-175
34681718-7	2021	In statherin, a preference for arginine-phosphoserine interaction over arginine-tyrosine accounts for a global expansion, despite a local contraction of the phosphorylated region, which implies that also non-charged residues can influence the effect of phosphorylation.	Arginine	31-39	statherin	Homo sapiens	3-12
34681718-7	2021	In statherin, a preference for arginine-phosphoserine interaction over arginine-tyrosine accounts for a global expansion, despite a local contraction of the phosphorylated region, which implies that also non-charged residues can influence the effect of phosphorylation.	Arginine	71-79	statherin	Homo sapiens	3-12
34641605-0	2021	Simulation of the Interactions of Arginine with Wild-Type GALT Enzyme and the Classic Galactosemia-Related Mutant p.Q188R by a Computational Approach.	Arginine	34-42	galactose-1-phosphate uridylyltransferase	Homo sapiens	58-62
34641606-0	2021	l-Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cells.	Arginine	0-10	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	51-55
34641606-3	2021	We herein report our in silico and experimental investigations of rutin as a SARS-CoV-2 Mpro inhibitor and of its water solubility improvement obtained by mixing it with l-arginine.	Arginine	170-180	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	88-92
34697388-6	2021	Arginine-mediated methylation of DDX5 is required for its interaction with Thrap3, and the Thrap3-DDX5 axis induces the recruitment of 5"-3" exoribonuclease 2 (XRN2) into R-loops.	Arginine	0-8	thyroid hormone receptor associated protein 3	Homo sapiens	75-81
34454165-7	2021	Notably, the expression levels of Rab7 and Atg5 were markedly up-regulated in MLN4924 treated cells and mice subjected to H2O2 or MI/R, respectively, while knockdown of Sirt1 in cells and heart tissue largely blocked such effect and induced autophagosome accumulation by inhibiting its fusion with lysosomes.	Arginine	133-134	RAB7, member RAS oncogene family	Mus musculus	34-38
34659087-2	2021	To elucidate the scientific relationship in neuro-endocrinology between Meniere"s disease and stress, we examined the surgical results of endolymphatic sac drainage surgery and changes in stress-induced plasma arginine-vasopressin levels.	Arginine	210-218	arginine vasopressin	Homo sapiens	219-230
34679660-11	2021	Thus, we propose that Arg can offer a hydrogen bond-rich, acidic-like microenvironment in RDL2 in which thiosulfate decomposes to release sulfane sulfur.	Arginine	22-25	thiosulfate sulfurtransferase RDL2	Saccharomyces cerevisiae S288C	90-94
34553653-3	2021	Decreased nitric oxide (NO) bioavailability was found to be associated with anomalous endothelial function because of either its reduced production level by endothelial NO synthase (eNOS) which synthesize this potent endogenous vasodilator from L-arginine or its enhanced breakdown due to severe oxidative stress and eNOS uncoupling.	Arginine	245-255	nitric oxide synthase 3	Homo sapiens	157-180
34553653-3	2021	Decreased nitric oxide (NO) bioavailability was found to be associated with anomalous endothelial function because of either its reduced production level by endothelial NO synthase (eNOS) which synthesize this potent endogenous vasodilator from L-arginine or its enhanced breakdown due to severe oxidative stress and eNOS uncoupling.	Arginine	245-255	nitric oxide synthase 3	Homo sapiens	182-186
34576162-0	2021	TAR RNA Mediated Folding of a Single-Arginine-Mutant HIV-1 Tat Protein within HeLa Cells Experiencing Intracellular Crowding.	Arginine	37-45	RNA binding motif protein 8A	Homo sapiens	0-3
34573721-3	2021	The main results show the crucial role of arginine in the viability/proliferation of intestinal cells evaluated by an MTT assay, and in the positive regulation of the expression of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6, IL-8) and anti-inflammatory (TGF-beta) cytokines.	Arginine	42-50	interleukin 1 alpha	Sus scrofa	210-219
34546425-5	2021	Arginine-rich HD5 is found to strongly interact with a LPS surface.	Arginine	0-8	defensin alpha 5	Homo sapiens	14-17
34546425-6	2021	Upon arrival, arginines on HD5 interact with lipid A head groups (a top part of LPS) and then drag these charged moieties down into a hydrophobic core resulting in the formation of water-filled pore.	Arginine	14-23	defensin alpha 5	Homo sapiens	27-30
34546425-9	2021	The interactions of arginine-lipid A head groups play a major role in adhering a cationic HD5 on a membrane surface and retarding a HD5 passage in the meantime.	Arginine	20-28	defensin alpha 5	Homo sapiens	90-93
34546425-9	2021	The interactions of arginine-lipid A head groups play a major role in adhering a cationic HD5 on a membrane surface and retarding a HD5 passage in the meantime.	Arginine	20-28	defensin alpha 5	Homo sapiens	132-135
34531375-1	2021	Protein arginine methyltransferase 5 (PRMT5), a histone methyltransferase responsible for the symmetric dimethylation of histone H4 on Arg 3 (H4R3me2s), is an enzyme that participates in tumor cell progression in a variety of hematological malignancies.	Arginine	135-138	protein arginine methyltransferase 5	Homo sapiens	0-36
34531375-1	2021	Protein arginine methyltransferase 5 (PRMT5), a histone methyltransferase responsible for the symmetric dimethylation of histone H4 on Arg 3 (H4R3me2s), is an enzyme that participates in tumor cell progression in a variety of hematological malignancies.	Arginine	135-138	protein arginine methyltransferase 5	Homo sapiens	38-43
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	toll-like receptor 4	Rattus norvegicus	124-144
34482698-6	2021	Three PTH1-34 variants were generated by substituting two of the three lysine (Lys) residues with arginine, reserving a single Lys as the modification site in each sequence.	Arginine	98-106	parathyroid hormone	Homo sapiens	6-10
34575100-2	2021	Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that asymmetrically dimethylates the arginine residues of numerous substrate proteins.	Arginine	99-107	protein arginine methyltransferase 6	Homo sapiens	0-36
34575100-2	2021	Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that asymmetrically dimethylates the arginine residues of numerous substrate proteins.	Arginine	99-107	protein arginine methyltransferase 6	Homo sapiens	38-43
34575100-3	2021	PRMT6 introduces asymmetric dimethylation modification in the histone 3 at arginine 2 (H3R2me2a) and facilitates epigenetic regulation of global gene expression.	Arginine	75-83	protein arginine methyltransferase 6	Homo sapiens	0-5
34575100-5	2021	Here, we discuss (i) the biochemical aspects of enzyme kinetics, (ii) the structural features of PRMT6 and (iii) the diverse functional outcomes of PRMT6 mediated arginine methylation.	Arginine	163-171	protein arginine methyltransferase 6	Homo sapiens	148-153
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	toll-like receptor 4	Rattus norvegicus	146-150
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	tumor necrosis factor	Rattus norvegicus	232-260
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	tumor necrosis factor	Rattus norvegicus	262-271
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	interleukin 1 beta	Rattus norvegicus	274-291
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	interleukin 1 alpha	Rattus norvegicus	293-301
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	interleukin 6	Rattus norvegicus	308-321
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	interleukin 6	Rattus norvegicus	323-327
34466676-3	2021	Recent studies on fish have demonstrated that arginine influences nutrient metabolism, stimulates insulin release, is involved in nonspecific immune responses and antioxidant responses, and elevates disease resistance.	Arginine	46-54	insulin	Homo sapiens	98-105
34476934-2	2021	Protein arginine methyltransferase 5 (PRMT5) that promotes arginine methylation of histones is associated with inflammation of endothelial cell and is implicated in lung branching morphogenesis and progression of lung cancer.	Arginine	59-67	protein arginine methyltransferase 5	Homo sapiens	0-36
34476934-2	2021	Protein arginine methyltransferase 5 (PRMT5) that promotes arginine methylation of histones is associated with inflammation of endothelial cell and is implicated in lung branching morphogenesis and progression of lung cancer.	Arginine	59-67	protein arginine methyltransferase 5	Homo sapiens	38-43
34273021-7	2021	In addition, serum ADMA, SDMA, total methylated arginine load, and CRP levels were lower (p < 0.05) in the TNF-alpha group compared to the conventional treatment group.	Arginine	48-56	tumor necrosis factor	Homo sapiens	107-116
34135015-3	2021	Fasting glucagon, glucagon suppression by glucose, and acute glucagon response (AGR) to arginine were assessed during hyperglycemic clamps.	Arginine	88-96	glucagon	Homo sapiens	61-69
34564325-1	2021	Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS).	Arginine	72-82	nitric oxide synthase 3	Homo sapiens	86-111
34531748-8	2021	In addition, Nrf2 deficiency strikingly weakens the beneficial effects of AICAR on alleviation of liver injury, oxidative stress and NLRP3 inflammasome activation in L-arginine-induced PALI mice.	Arginine	166-176	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
34564325-1	2021	Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS).	Arginine	72-82	nitric oxide synthase 3	Homo sapiens	113-117
34564325-2	2021	eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane.	Arginine	160-170	nitric oxide synthase 3	Homo sapiens	0-4
34292288-2	2021	A Strecker type reaction on intermediate chiral Tfm-oxazolo-pyrrolidine and -piperidine provided the corresponding nitrile precursor of enantiopure (R) and (S) alpha-Tfm-proline and alpha-Tfm-pipecolic acid.	Arginine	149-150	androgen receptor	Homo sapiens	48-51
34449768-8	2021	In addition, Gly/Arg genotype of IRS1 gene was associated with significantly higher body mass index, fat mass, %body fat, triglycerides, cholesterol, alkaline phosphate, aspartate transaminase, fasting insulin and HOMA-IR levels in OSA and NAFLD subjects.	Arginine	17-20	insulin	Homo sapiens	202-209
34525929-9	2021	Then, multivariate Cox regression analysis was used to determine 4 key prognostic ARGs (CC3CL1, ERBB2, HIF-alpha and CXCR4) in WT.	Arginine	82-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-101
34292288-2	2021	A Strecker type reaction on intermediate chiral Tfm-oxazolo-pyrrolidine and -piperidine provided the corresponding nitrile precursor of enantiopure (R) and (S) alpha-Tfm-proline and alpha-Tfm-pipecolic acid.	Arginine	149-150	androgen receptor	Homo sapiens	188-191
34375583-4	2021	m6A-eRNAs mark highly active enhancers, where they recruit nuclear m6A reader YTHDC1 to phase separate into liquid-like condensates, in a manner dependent on its C terminus intrinsically disordered region and arginine residues.	Arginine	209-217	YTH domain containing 1	Homo sapiens	78-84
34539989-13	2021	CircUBXN7 suppressed cell apoptosis and inflammatory reaction induced by H/R via targeting miR-622.	Arginine	75-76	UBX domain protein 7	Mus musculus	0-9
34107273-11	2021	In Exp3, insulin secretion in response to high glucose and 10 mM arginine was 42.43 +-6.34 muU/ml.	Arginine	65-73	insulin	Homo sapiens	9-16
34365618-5	2021	RESULTS: The child was found to harbor a novel c.1906C>T hemizygous variant of the FGD1 gene, which has led to conversion of Arginine to Tryptophane at codon 636(p.Arg636Trp).	Arginine	125-133	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	83-87
34444938-1	2021	l-Arginine is an important nutrient in the infant diet that significantly regulates the maturation of the immune system in neonates, including the maturation of CD4+ T cells.	Arginine	0-10	CD4 molecule	Homo sapiens	161-164
34444938-9	2021	CpG dinucleotides at IL-13 promoter regions were hypomethylated after l-arginine stimulation.	Arginine	70-80	interleukin 13	Homo sapiens	21-26
34132576-6	2021	Mutational and sequence analysis revealed conserved lysine/arginine residues at positions 49/50 and 91 of betaC1 proteins to be essential for their ATPase activity.	Arginine	59-67	adenylate cyclase 1	Homo sapiens	106-112
34132576-8	2021	Mutating arginine 91 of betaC1 to alanine reduced its DNA-binding activity.	Arginine	9-17	adenylate cyclase 1	Homo sapiens	24-30
34132576-9	2021	The results of docking studies provided evidence for an overlap of the ATP-binding and DNA-binding regions of betaC1 and for the importance of arginine 91 for both ATP-binding and DNA-binding activities.	Arginine	143-151	adenylate cyclase 1	Homo sapiens	110-116
34132576-16	2021	The lysine/arginine residues conserved at positions 49 and 91 of betaC1 were found to be crucial for its ATPase function.	Arginine	11-19	adenylate cyclase 1	Homo sapiens	65-71
34423028-13	2021	Conclusions: ARGs may be a potential biomarker for HNSCC prognosis, and targeted therapies for FADD and NKX2-3 are possible to be a new strategy of HNSCC treatment.	Arginine	13-17	NK2 homeobox 3	Homo sapiens	104-110
34661075-5	2021	We show that (1) key platelet proteins are modified by arginine methylation; (2) incubation of human platelets with PRMT inhibitors for 4 h results in impaired capacity of platelets to aggregate in response to thrombin and collagen, with IC50 values in the muM range; and (3) treatment with PRMT inhibitors leads to decreased membrane expression and reduced activation of the critical platelet integrin alphaIIbbeta3.	Arginine	55-63	coagulation factor II, thrombin	Homo sapiens	210-218
34370644-1	2022	BACKGROUND: The reported binding mode of ibuprofen in the COX-2 binding site indicated that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel and does not extend into the pocket.	Arginine	124-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-63
34356085-7	2021	The only other mutation previously described in the fifth exon of CRYBB3 is a missense variant that causes a change in amino acid from the same 156th amino acid to arginine and has been associated with pediatric cataract and microphthalmia.	Arginine	164-172	crystallin beta B3	Homo sapiens	66-72
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	163-166	tumor protein p53	Homo sapiens	29-33
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	163-166	tumor protein p53	Homo sapiens	130-134
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	171-174	tumor protein p53	Homo sapiens	29-33
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	171-174	tumor protein p53	Homo sapiens	130-134
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	175-178	tumor protein p53	Homo sapiens	29-33
34393505-5	2021	Results: The distribution of TP53 Pro72Arg differed in T2DM patients from the controls, with a moderately increased proportion of TP53 Arg72 variant carriers (Pro/Arg and Arg/Arg genotypes) (88.3% vs 81.2%, p=0.022; OR=1.089, 95% CI=1.018-1.164).	Arginine	175-178	tumor protein p53	Homo sapiens	130-134
34393505-8	2021	Conclusion: There was a significant association of the TP53 Pro72Arg polymorphism with susceptibility to T2DM, and the homozygous Arg/Arg genotype of this gene locus might be a protective factor for diabetic complications.	Arginine	130-133	tumor protein p53	Homo sapiens	55-59
34393505-8	2021	Conclusion: There was a significant association of the TP53 Pro72Arg polymorphism with susceptibility to T2DM, and the homozygous Arg/Arg genotype of this gene locus might be a protective factor for diabetic complications.	Arginine	134-137	tumor protein p53	Homo sapiens	55-59
34184805-0	2021	Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.	Arginine	15-23	snail family transcriptional repressor 1	Homo sapiens	0-5
34184805-7	2021	Collectively, these findings suggest that TGF-beta and Snail promote arginine synthesis via inhibiting LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly and this complex can serve as potential target for the development of new therapeutic approaches to treat CRC.	Arginine	69-77	snail family transcriptional repressor 1	Homo sapiens	55-60
34181566-4	2021	DESIGN: 65 healthy volunteers underwent either the hypertonic saline or arginine infusion test, known to stimulate copeptin, or the oral macimorelin test, known to stimulate growth hormone.	Arginine	72-80	arginine vasopressin	Homo sapiens	115-123
34181566-7	2021	RESULTS: As expected, copeptin increased in response to hypertonic saline and arginine infusion (p<0.001), and growth hormone increased to oral macimorelin (p<0.001).	Arginine	78-86	arginine vasopressin	Homo sapiens	22-30
34444799-5	2021	Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature.	Arginine	143-151	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	52-54
34444799-5	2021	Various interventions can lower the oxidant load in PN, including the supplementation of PN with antioxidant vitamins, glutathione, additional arginine and additional cysteine; reduced levels of pro-oxidant nutrients such as iron; protection from light and oxygen; and proper storage temperature.	Arginine	143-151	U6 snRNA biogenesis phosphodiesterase 1	Homo sapiens	89-91
34373747-10	2021	Mechanically, WDR77 enhanced PRMT5-triggered symmetric dimethylation of arginine 3 on H4 (H4R3me2s) on the cccDNA minichromosome to control cccDNA transcription.	Arginine	72-80	protein arginine methyltransferase 5	Homo sapiens	29-34
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	tripartite motif containing 31	Homo sapiens	152-158
34165173-7	2021	Silencing of RASA1 protected against HI/R-induced H9C2 cell injury.	Arginine	40-41	RAS p21 protein activator 1	Rattus norvegicus	13-18
34297442-8	2022	In silico modeling of the ENPP1 wild-type and ENPP1 with the p.C176R mutation showed the residue Arg-176 disturbed the fold of the loop conformation.	Arginine	97-100	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	26-31
34297442-8	2022	In silico modeling of the ENPP1 wild-type and ENPP1 with the p.C176R mutation showed the residue Arg-176 disturbed the fold of the loop conformation.	Arginine	97-100	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	46-51
34298755-1	2021	Arginine is an amino acid critically involved in multiple cellular processes including the syntheses of nitric oxide and polyamines, and is a direct activator of mTOR, a nutrient-sensing kinase strongly implicated in carcinogenesis.	Arginine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	162-166
34372579-6	2021	An Arg located in the structurally equivalent BH1 region of ORFV125 forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that mimics the canonical ionic interaction seen in host Bcl-2:BH3 motif complexes.	Arginine	3-6	BCL2 apoptosis regulator	Homo sapiens	204-209
34212433-7	2022	The level of serum nitric oxide (NO) and activity of nitric oxide synthase (NOS) also increased in 150-day-old boars in the ARG group (p < 0.05).	Arginine	124-127	nitric oxide synthase 2	Homo sapiens	53-74
34299249-9	2021	In this paper, the signaling of TRAIL and ADI-PEG20-induced arginine deprivation including the main mechanism of resistance to these drugs and exemplary combination strategies is discussed.	Arginine	60-68	TNF superfamily member 10	Homo sapiens	32-37
34356605-5	2021	In endothelial cells, NO is produced by endothelial nitric oxide synthase (eNOS) from L-Arg, with tetrahydrobiopterin (BH4) as an essential cofactor.	Arginine	86-91	nitric oxide synthase 3	Homo sapiens	40-73
34356605-5	2021	In endothelial cells, NO is produced by endothelial nitric oxide synthase (eNOS) from L-Arg, with tetrahydrobiopterin (BH4) as an essential cofactor.	Arginine	86-91	nitric oxide synthase 3	Homo sapiens	75-79
34356605-7	2021	What is particularly important is the fact that hypoxia contributes to the depletion of cofactor BH4 and deficiency of substrate L-Arg, and thus elicits eNOS uncoupling-a state in which the enzyme produces superoxide instead of NO.	Arginine	129-134	nitric oxide synthase 3	Homo sapiens	153-157
34182489-7	2021	RESULTS: A substitution in the NR4A1 gene at codon 293 resulting in an amino acid change from arginine to serine was identified only in the affected sisters.	Arginine	94-102	nuclear receptor subfamily 4 group A member 1	Homo sapiens	31-36
34173673-8	2021	Thus, our findings indicate that NOB may relieve H/R-induced damage in H9c2 cells by modulating the miR-433/SIRT1 axis.	Arginine	51-52	microRNA 433	Rattus norvegicus	100-107
34209110-1	2021	Positively charged groups that mimic arginine or lysine in a natural substrate of trypsin are necessary for drugs to inhibit the trypsin-like serine protease TMPRSS2 that is involved in the viral entry and spread of coronaviruses, including SARS-CoV-2.	Arginine	37-45	transmembrane serine protease 2	Homo sapiens	158-165
34124902-4	2021	On the basis of this structure, we have now designed four arginine mutants of glucagon that resist fibrillization at pharmaceutical concentrations for weeks.	Arginine	58-66	glucagon	Homo sapiens	78-86
34124902-10	2021	Therefore, these arginine mutants of glucagon are promising alternative compounds for treating hypoglycemia.	Arginine	17-25	glucagon	Homo sapiens	37-45
34214348-8	2021	The ERbeta agonist was a compound that has parameters similar to 17beta-estradiol in its interaction with 3OLS protein, which has a pharmacophore distance of 10.862 A, and binding to amino acids His 475 and Glu 305 or Arg 346 at receptor-ligand docking simulation.	Arginine	218-221	Era like 12S mitochondrial rRNA chaperone 1	Homo sapiens	4-10
34143841-0	2021	Replacement of Arg in the conserved N-terminal RLFDQxFG motif affects physico-chemical properties and chaperone-like activity of human small heat shock protein HspB8 (Hsp22).	Arginine	15-18	heat shock protein family B (small) member 8	Homo sapiens	160-165
34143841-0	2021	Replacement of Arg in the conserved N-terminal RLFDQxFG motif affects physico-chemical properties and chaperone-like activity of human small heat shock protein HspB8 (Hsp22).	Arginine	15-18	heat shock protein family B (small) member 8	Homo sapiens	167-172
34145242-0	2021	Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells.	Arginine	0-8	methyltransferase like 14	Mus musculus	24-31
34143841-9	2021	It is concluded that the irreplaceable Arg residue located in the only highly conservative motif in the N-terminal domain of all sHsp proteins affects the oligomeric structure and key properties of HspB8.	Arginine	39-42	heat shock protein family B (small) member 8	Homo sapiens	198-203
34145242-9	2021	Collectively, our findings show that arginine methylation of METTL14 stabilizes the binding of the m6A methyltransferase complex to its substrate RNA, thereby promoting global m6A modification and mESC endoderm differentiation.	Arginine	37-45	methyltransferase like 14	Mus musculus	61-68
34035177-4	2021	Here, we show that complement component 1s (C1s) in serum cleaves PfEMP1 at semiconserved arginine motifs located at interdomain regions between the receptor-binding domains, rendering the IE incapable of binding the two main PfEMP1 receptors, CD36 and endothelial protein C receptor (EPCR).	Arginine	90-98	complement C1s	Homo sapiens	44-47
34103528-0	2021	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.	Arginine	15-23	protein arginine methyltransferase 5	Homo sapiens	0-5
34103528-3	2021	Emerging evidence indicates that arginine methylation is involved in modulating AKT signaling pathway.	Arginine	33-41	AKT serine/threonine kinase 1	Homo sapiens	80-83
34103528-5	2021	Here we report that protein arginine methyltransferase 5 (PRMT5), but not other PRMTs, promotes AKT activation by catalyzing symmetric dimethylation of AKT1 at arginine 391 (R391).	Arginine	160-168	protein arginine methyltransferase 5	Homo sapiens	20-56
34103528-5	2021	Here we report that protein arginine methyltransferase 5 (PRMT5), but not other PRMTs, promotes AKT activation by catalyzing symmetric dimethylation of AKT1 at arginine 391 (R391).	Arginine	160-168	protein arginine methyltransferase 5	Homo sapiens	58-63
34103528-5	2021	Here we report that protein arginine methyltransferase 5 (PRMT5), but not other PRMTs, promotes AKT activation by catalyzing symmetric dimethylation of AKT1 at arginine 391 (R391).	Arginine	160-168	AKT serine/threonine kinase 1	Homo sapiens	96-99
34103528-5	2021	Here we report that protein arginine methyltransferase 5 (PRMT5), but not other PRMTs, promotes AKT activation by catalyzing symmetric dimethylation of AKT1 at arginine 391 (R391).	Arginine	160-168	AKT serine/threonine kinase 1	Homo sapiens	152-156
34112944-0	2021	ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues.	Arginine	70-78	TAR DNA binding protein	Homo sapiens	35-41
34112944-3	2021	The results revealed: 1) ATP induces and subsequently dissolves LLPS of TDP-43 PLD by specifically binding Arg saturated at 1:100.	Arginine	107-110	TAR DNA binding protein	Homo sapiens	72-78
34169098-14	2021	In conclusion, our results suggest that TLR4 activation protects CFs from apoptosis induced by sI/R through the activation of Akt and ERK1/2 signaling pathways.	Arginine	98-99	toll-like receptor 4	Rattus norvegicus	40-44
34169098-14	2021	In conclusion, our results suggest that TLR4 activation protects CFs from apoptosis induced by sI/R through the activation of Akt and ERK1/2 signaling pathways.	Arginine	98-99	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
34162039-6	2021	PXXP and BAG domains of BAG3 played an essential role in BAG3 attenuating cardiomyocytes apoptosis induced by H/R through the JNK signalling pathway.	Arginine	112-113	mitogen-activated protein kinase 8	Homo sapiens	126-129
34070942-10	2021	Overall, our data suggest that human parietal cells in culture, as well as from the gastric antrum, synthesize serotonin and release it after treatment with L-Arg via an HTR3-related mechanism.	Arginine	157-162	5-hydroxytryptamine receptor 3A	Homo sapiens	170-174
34072439-6	2021	Sequencing of the chloroplast genome and transcriptome of the DH parents and reciprocal hybrids, respectively, revealed one maternally transmitted non-synonymous single nucleotide polymorphism (SNP) in the chloroplast F1FO-ATP synthase (CF1FO-ATPase) beta-subunit gene (atpB) of CH which confers an amino acid change from threonine to arginine.	Arginine	335-343	ATP synthase CF1 beta subunit	Cucumis sativus	270-274
34113620-5	2021	Further study revealed that the expression of lysine demethylases (JMJD1A, JMJD1B, JMJD1C, and KDM6B) was significantly reduced in Prmt5-deficient SSCs and that the level of permissive arginine methylation H3R2me2s was significantly decreased at the upstream promoter region of these genes in Prmt5-deficient SSCs.	Arginine	185-193	protein arginine methyltransferase 5	Homo sapiens	293-298
34095122-5	2021	Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism.	Arginine	130-138	nitric oxide synthase 3	Homo sapiens	0-33
34095122-5	2021	Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism.	Arginine	130-138	nitric oxide synthase 3	Homo sapiens	35-39
34084766-2	2021	Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation.	Arginine	56-66	nitric oxide synthase 2, inducible	Mus musculus	33-37
34123401-0	2021	L-arginine as a potential GLP-1-mediated immunomodulator of Th17-related cytokines in people with obesity and asthma.	Arginine	0-10	glucagon	Homo sapiens	26-31
34377959-4	2021	Furthermore, recent studies have shown that L-arginine induces utrophin upregulation in adult mdx mice.	Arginine	44-54	utrophin	Mus musculus	63-71
34377959-5	2021	We hypothesized that L-arginine treatment also induces utrophin upregulation to prevent the development of muscle weakness in neonatal mdx mice.	Arginine	21-31	utrophin	Mus musculus	55-63
34377959-6	2021	Hence, L-arginine should also prevent progressive muscle destruction via utrophin upregulation in mdx neonatal mice.	Arginine	7-17	utrophin	Mus musculus	73-81
34233561-1	2021	Hb Tacoma (beta30(B12)Arg Ser) is a missense variant that is caused by either an AGG>AGT or AGG>AGC substitution at codon 30 of the HBB gene.	Arginine	22-25	angiotensinogen	Homo sapiens	85-88
34123401-3	2021	One approach that might augment GLP-1 levels would be dietary supplementation with L-arginine.	Arginine	83-93	glucagon	Homo sapiens	32-37
34123401-5	2021	In a posthoc analysis of a randomized, placebo-controlled human clinical trial of L-arginine supplementation in people with asthma and predominantly with obesity, the results showed that 12 weeks of continuous L-arginine supplementation significantly decreased the level of IL-21 (p = 0.02) and increased the level of insulin (p = 0.02).	Arginine	82-92	insulin	Homo sapiens	318-325
34123401-5	2021	In a posthoc analysis of a randomized, placebo-controlled human clinical trial of L-arginine supplementation in people with asthma and predominantly with obesity, the results showed that 12 weeks of continuous L-arginine supplementation significantly decreased the level of IL-21 (p = 0.02) and increased the level of insulin (p = 0.02).	Arginine	210-220	insulin	Homo sapiens	318-325
34123401-6	2021	A high arginine level and arginine/ADMA ratio were significantly associated with lower CCL-20 and TNF-alpha levels.	Arginine	7-15	tumor necrosis factor	Homo sapiens	98-107
34123401-6	2021	A high arginine level and arginine/ADMA ratio were significantly associated with lower CCL-20 and TNF-alpha levels.	Arginine	26-34	tumor necrosis factor	Homo sapiens	98-107
35490584-11	2022	The excellent cardioprotective action of such compounds rely on enhancing the endogenous antioxidative system by upregulating the Nrf2 signaling pathway in vitro and in vivo against MI/R damage.	Arginine	185-186	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
34302694-4	2021	Endogenous NO is produced from L-arginine under catalysis of three isoforms of NOS (eNOS, iNOS, and nNOS).	Arginine	31-41	nitric oxide synthase 3	Homo sapiens	84-88
34302694-4	2021	Endogenous NO is produced from L-arginine under catalysis of three isoforms of NOS (eNOS, iNOS, and nNOS).	Arginine	31-41	nitric oxide synthase 2	Homo sapiens	90-94
34725288-5	2021	RESULTS: Results: Pregnant women with preeclampsia showed the imbalance between pro- and anti-inflammatory cytokines in favour of TNF-alpha and INF-gamma under the decrease in IL-10 that results in an imbalance in the activity of enzymes regulating L-arginine metabolism, with increased iNOS activity and decreased arginine activity.	Arginine	249-259	tumor necrosis factor	Homo sapiens	130-139
34338573-10	2021	However, inhibition of AMPK reversed the CTRP13-mediated activation of Nrf2/ARE signaling and the cardiac-protective effect in H/R-exposed H9c2 cells.	Arginine	129-130	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	23-27
34338573-11	2021	Additionally, silencing of Nrf2 reversed the protective effects of CTRP13 against H/R-stimulated oxidative stress and apoptosis in H9c2 cells.	Arginine	84-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	27-31
34090290-5	2021	RESULTS: Results: It was established that distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes for Arg16Gly polymorphism in the beta2 -AR gene was 44.2%, 40.0%, 15.8% in the control group vs. 31.3%; 45.7% and 23.0 among BA patients, respectively (chi2 = 6.59; r = 0.037).	Arginine	58-61	ATPase H+ transporting V0 subunit a2	Homo sapiens	131-136
34090290-5	2021	RESULTS: Results: It was established that distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes for Arg16Gly polymorphism in the beta2 -AR gene was 44.2%, 40.0%, 15.8% in the control group vs. 31.3%; 45.7% and 23.0 among BA patients, respectively (chi2 = 6.59; r = 0.037).	Arginine	62-65	ATPase H+ transporting V0 subunit a2	Homo sapiens	131-136
34090290-5	2021	RESULTS: Results: It was established that distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes for Arg16Gly polymorphism in the beta2 -AR gene was 44.2%, 40.0%, 15.8% in the control group vs. 31.3%; 45.7% and 23.0 among BA patients, respectively (chi2 = 6.59; r = 0.037).	Arginine	67-70	ATPase H+ transporting V0 subunit a2	Homo sapiens	131-136
34090290-7	2021	BA risk was 1.74 times higher in the minor allele carriers (Arg/Gly + Gly/Gly genotypes) for Arg16Gly polymorphism in the beta2 -AR gene.	Arginine	60-63	ATPase H+ transporting V0 subunit a2	Homo sapiens	122-127
35549174-3	2022	This design strategy is demonstrated in the group of trinuclear Co(III) spin-crossover compounds ((CpCo(OP(OR)2)3)2Co)(SbCl6) where Cp = cyclopentadienyl and R = Me (1), Et (2), i-Pr (3), and t-Bu (4).	Arginine	158-159	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	64-71
35533947-6	2022	NO is a gaseous compound that easily diffuses through the cell membrane and is produced through the oxidation reaction of l-Arginine to l-citrulline catalyzed by nitric oxide synthase (NOS).	Arginine	122-132	nitric oxide synthase 2	Homo sapiens	162-183
35490898-2	2022	Gag-PM interactions are mediated by the matrix (MA) domain, which contains a myristoyl group (myr) and a basic patch formed by lysine and arginine residues.	Arginine	138-146	Pr55	Human T-cell leukemia virus type I	0-3
35583463-6	2022	Furthermore, l -arginine contributed to the expression of phase II detoxification genes (SULT2B1, GSTA1, GSTM3, and GPX4).	Arginine	13-24	sulfotransferase family 2B member 1	Homo sapiens	89-96
35616019-0	2022	L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	0-10	thymoma viral proto-oncogene 1	Mus musculus	158-161
35616019-8	2022	In vivo, it was further confirmed that 0.1% L-arginine can activate the PI3K/AKT/mTOR signalling pathway in the MG of pubertal mice.	Arginine	44-54	thymoma viral proto-oncogene 1	Mus musculus	77-80
35616019-9	2022	These results were able to indicate that L-arginine stimulates the development of MG in pubertal mice through the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	41-51	thymoma viral proto-oncogene 1	Mus musculus	126-129
35477090-7	2022	Further experiments found that OCA, ASS1, and arginine supplement can rescue TAA-mediated hepatocytes apoptosis by decreasing the protein levels of Cyto C, PARP, and Caspase 3.	Arginine	46-54	poly(ADP-ribose) polymerase 1	Homo sapiens	156-160
35477090-7	2022	Further experiments found that OCA, ASS1, and arginine supplement can rescue TAA-mediated hepatocytes apoptosis by decreasing the protein levels of Cyto C, PARP, and Caspase 3.	Arginine	46-54	caspase 3	Homo sapiens	166-175
35608157-5	2022	Simulations of wild-type PDZ and arginine mutants suggest that contacts with Arg79/85 in hPTP1E/MAGI1 are more important for the EQVEAV peptide than for EQVSAV.	Arginine	33-41	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	96-101
35380161-5	2022	ADP-ribosylation on arginine and serine is reversed by ARH1 and ARH3 respectively, whereas macrodomain-containing MACROD1, MACROD2 and TARG1 reverse modification of acidic residues.	Arginine	20-28	low density lipoprotein receptor adaptor protein 1	Homo sapiens	55-59
35619558-5	2022	Although perioperative arginine did not prevent immediate NK cell immunoparalysis after surgery, it did accelerate their return to preoperative cytotoxicity, IFN-gamma secretion, and activating receptor expression.	Arginine	23-31	interferon gamma	Homo sapiens	158-167
35598222-8	2022	Results showed exercise training and L-arginine supplementation promoted Cat and GSH activities and decreased MDA activity following myocardial ischemia-reperfusion injury in non-infarcted area.	Arginine	37-47	catalase	Rattus norvegicus	73-76
35610266-2	2022	During damage bypass, Rev1 utilizes a protein-template mechanism of DNA synthesis, where the templating DNA base is evicted from the Rev1 active site and replaced by an arginine side chain that preferentially binds incoming dCTP.	Arginine	169-177	REV1 DNA directed polymerase	Homo sapiens	22-26
35610266-2	2022	During damage bypass, Rev1 utilizes a protein-template mechanism of DNA synthesis, where the templating DNA base is evicted from the Rev1 active site and replaced by an arginine side chain that preferentially binds incoming dCTP.	Arginine	169-177	REV1 DNA directed polymerase	Homo sapiens	133-137
35549216-4	2022	Acylation occurred in two stages: (i) proton transfer from Ser441 to His296 concerted with the nucleophilic attack of Ser441 to the substrate"s P1-Arg and (ii) proton transfer from His296 to the P1"-Ser residue concerted with the cleavage of the ArgP1-SerP1" peptide bond, with a Gibbs activation energy of 17.1 and 15.8 kcal mol-1, relative to the reactant.	Arginine	147-150	stress associated endoplasmic reticulum protein 1	Homo sapiens	252-258
35609127-5	2022	PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of NF-kappaB signaling.	Arginine	29-37	DExH-box helicase 9	Homo sapiens	53-72
35609127-5	2022	PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of NF-kappaB signaling.	Arginine	29-37	DExH-box helicase 9	Homo sapiens	74-78
35613513-1	2022	Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER).	Arginine	0-8	insulin	Homo sapiens	18-28
35613513-8	2022	At the molecular level, less interaction of proinsulin with UGGT1 was observed in both human UGGT1R1526C and mouse UGGT1L1518C with/without arginine.	Arginine	140-148	insulin	Homo sapiens	44-54
35590365-0	2022	Arginine regulates inflammation response-induced by Fowl Adenovirus serotype 4 via JAK2/STAT3 pathway.	Arginine	0-8	signal transducer and activator of transcription 3	Gallus gallus	88-93
35590365-10	2022	CONCLUSIONS: These above results provide new insight that arginine protects hepatocytes against inflammation induced by FAdV-4 through JAK2/STAT3 signaling pathway.	Arginine	58-66	signal transducer and activator of transcription 3	Gallus gallus	140-145
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	73-81	signal transducer and activator of transcription 3	Gallus gallus	249-254
35579101-5	2022	After instillation, the presence of integrin-beta1 endows coated nanoparticles with steady adhesion via specific binding to Arg-Gly-Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on ocular surface.	Arginine	124-127	fibronectin 1	Homo sapiens	152-163
35521789-2	2022	The most reliable approaches are copeptin measurements after hypertonic saline infusion or arginine, which is a known growth hormone secretagogue but has recently also been shown to stimulate the neurohypophysis.	Arginine	91-99	growth hormone 1	Homo sapiens	118-132
35577075-0	2022	Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1.	Arginine	25-33	AKT serine/threonine kinase 1	Homo sapiens	58-61
35549865-9	2022	Of interest, restoration of NO by L-arginine may attenuate SARS-CoV-2 infection through different mechanisms, including reduction binding of SARS-CoV-2 to ACE2, inhibition of transmembrane protease serine type 2 (TMPRSS2) a critical for activation of SARS-CoV-2 spike protein and cellular entry, inhibition proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy.	Arginine	34-44	transmembrane serine protease 2	Homo sapiens	213-220
35625861-6	2022	The most frequent association of ARG in VRE was vanA-tet(M)-ermB.	Arginine	33-36	VanA	Enterococcus faecalis	48-52
35521789-3	2022	Similar to arginine, glucagon stimulates growth hormone release, but its effect on the neurohypophysis is poorly studied.	Arginine	11-19	growth hormone 1	Homo sapiens	41-55
35434944-11	2022	Mechanistically, HSF1 interacted with protein arginine methyltransferase 5 (PRMT5) and jointly induced the monomethylation of histone H3 at arginine 2 (H3R2me1) and symmetric dimethylation of histone H3 at arginine 2 (H3R2me2s).	Arginine	140-148	protein arginine methyltransferase 5	Homo sapiens	76-81
35533195-5	2022	Here, we generated recombinant EBOVs encoding glycine (G) or arginine (R) mutations at VP35/K309 (rEBOV-VP35/K309G/-R) and show that both mutations prohibit VP35/K309 ubiquitination.	Arginine	61-69	polymerase complex protein	Reston ebolavirus	87-91
35533195-5	2022	Here, we generated recombinant EBOVs encoding glycine (G) or arginine (R) mutations at VP35/K309 (rEBOV-VP35/K309G/-R) and show that both mutations prohibit VP35/K309 ubiquitination.	Arginine	61-69	polymerase complex protein	Reston ebolavirus	104-108
35533195-5	2022	Here, we generated recombinant EBOVs encoding glycine (G) or arginine (R) mutations at VP35/K309 (rEBOV-VP35/K309G/-R) and show that both mutations prohibit VP35/K309 ubiquitination.	Arginine	61-69	polymerase complex protein	Reston ebolavirus	157-161
35390161-5	2022	Acidic patch binding by VRK1 is mediated by an arginine-rich flexible C-terminal tail.	Arginine	47-55	VRK serine/threonine kinase 1	Homo sapiens	24-28
35508110-5	2022	iNOS expression was coupled to metabolic rewiring, inducing increased diversion of extracellular L-arginine through the arginosuccinate shunt and urea cycle to produce nitric oxide (NO), directly mediating bacterial clearance.	Arginine	97-107	nitric oxide synthase 2	Homo sapiens	0-4
35434944-11	2022	Mechanistically, HSF1 interacted with protein arginine methyltransferase 5 (PRMT5) and jointly induced the monomethylation of histone H3 at arginine 2 (H3R2me1) and symmetric dimethylation of histone H3 at arginine 2 (H3R2me2s).	Arginine	206-214	protein arginine methyltransferase 5	Homo sapiens	38-74
35434944-11	2022	Mechanistically, HSF1 interacted with protein arginine methyltransferase 5 (PRMT5) and jointly induced the monomethylation of histone H3 at arginine 2 (H3R2me1) and symmetric dimethylation of histone H3 at arginine 2 (H3R2me2s).	Arginine	206-214	protein arginine methyltransferase 5	Homo sapiens	76-81
35481627-8	2022	Substituting the arginine in Physaleae POS1-like by histidine completely abolished their function in the fruits and the protein-protein interaction (PPI) with calreticulin-3.	Arginine	17-25	calreticulin 3	Homo sapiens	159-173
35182051-1	2022	Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of L-arginine to nitric oxide (NO) in response to a significant number of signaling pathways.	Arginine	97-107	nitric oxide synthase 3	Homo sapiens	0-23
35182051-1	2022	Nitric oxide synthase 3 (NOS3) is a major vasoprotective enzyme that catalyzes the conversion of L-arginine to nitric oxide (NO) in response to a significant number of signaling pathways.	Arginine	97-107	nitric oxide synthase 3	Homo sapiens	25-29
35066566-17	2022	Taken together, our results show that the ROR/miR-185-5p/CDK6 axis modulates cell pyroptosis induced by H/R and the inflammatory response of HCMs.	Arginine	106-107	cyclin dependent kinase 6	Homo sapiens	57-61
35535157-6	2022	MI/R-induced expression of IL-6, TNF-alpha, and IL-1beta in the hearts was reduced by LrB treatment.	Arginine	3-4	interleukin 6	Mus musculus	27-31
35535157-6	2022	MI/R-induced expression of IL-6, TNF-alpha, and IL-1beta in the hearts was reduced by LrB treatment.	Arginine	3-4	tumor necrosis factor	Mus musculus	33-42
35500745-5	2022	PRMT5 and symmetric dimethylation at histone H4 arginine 3 (H4R3me2s) directly associate with chromatin of P21 to suppress its transcription.	Arginine	48-56	protein arginine methyltransferase 5	Homo sapiens	0-5
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Arginine	48-56	lin-28 homolog A	Homo sapiens	38-44
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Arginine	48-56	lin-28 homolog A	Homo sapiens	105-111
35262736-9	2022	Mutation of the lysine 177 residue of Lin28A to arginine abrogated the ubiquitination and degradation of Lin28A which were accelerated by Kap1 silencing.	Arginine	48-56	tripartite motif containing 28	Homo sapiens	138-142
35563766-9	2022	Cumulatively, our results demonstrate that YTHDC1 binding to SRSF3 is regulated by not only hypo-phosphorylated residues of arginine/serine-rich (RS) domain of SRSF3 but also other parts of SRSF3 via YTHDC1 N- or C-terminal residues.	Arginine	124-132	YTH domain containing 1	Homo sapiens	43-49
35563196-6	2022	These three compounds could bind to PRMT5 through different binding modes and inhibit histone arginine methylation.	Arginine	94-102	protein arginine methyltransferase 5	Homo sapiens	36-41
35563766-9	2022	Cumulatively, our results demonstrate that YTHDC1 binding to SRSF3 is regulated by not only hypo-phosphorylated residues of arginine/serine-rich (RS) domain of SRSF3 but also other parts of SRSF3 via YTHDC1 N- or C-terminal residues.	Arginine	124-132	YTH domain containing 1	Homo sapiens	200-206
35470495-6	2022	Compared to the control group, the anti-inflammatory action of l-arginine is reflected by upregulation of hepatic interleukin-10 (IL-10) and the suppression of hepatic cyclooxygenase-2, tumor necrotic factor alpha, IL-1beta, and IL-6 expressions in growing rats.	Arginine	63-73	interleukin 1 alpha	Rattus norvegicus	215-223
35470495-6	2022	Compared to the control group, the anti-inflammatory action of l-arginine is reflected by upregulation of hepatic interleukin-10 (IL-10) and the suppression of hepatic cyclooxygenase-2, tumor necrotic factor alpha, IL-1beta, and IL-6 expressions in growing rats.	Arginine	63-73	interleukin 6	Rattus norvegicus	229-233
35470495-7	2022	With l-arginine administration, the activation of nuclear factor-kappaB (NF-kappaB) was efficaciously inhibited through the upregulation of inhibitory kappaBalpha, and the depression of phosphoinositide 3-kinase/protein kinase B (PI3K/Akt).	Arginine	5-15	AKT serine/threonine kinase 1	Rattus norvegicus	235-238
35470495-9	2022	A significant finding of this study was that the anti-inflammatory mechanism exerted by l-arginine was to inhibit NF-kappaB activation via downregulating PI3K/Akt.	Arginine	88-98	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
35460333-3	2022	The structure-activity relationship studies have shown that PTn-R2-C6, which is a type of polymers that have two arginine residues and a flexible hexanoic acid linker in each side chain, exhibited excellent pore-formation ability on cell membrane.	Arginine	113-121	pleiotrophin	Homo sapiens	60-63
35442741-6	2022	Human cancer-associated moesin mutations at the conserved arginine-295 residue similarly enhanced MLL-ENL-driven leukemogenesis.	Arginine	58-66	moesin	Homo sapiens	24-30
35175765-6	2022	Molecular docking studies revealed that these compounds bind with their polar region in the cavity over Arg-120, and their lipophilic part is orientated to the HEM cofactor similarly to the natural substrate arachidonic acid in the catalytic site of COX-2.	Arginine	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	250-255
35460591-5	2022	In addition, by using precise delivery of solutes into the xylem stream of Populus trees in their natural environment, we found that delay of autumn senescence was dependent on the form of N administered: inorganic N (NO3 - ) delayed senescence but amino acids (Arg, Glu, Gln, and Leu) did not.	Arginine	262-265	NBL1, DAN family BMP antagonist	Homo sapiens	218-221
35489243-5	2022	The hydrophobic cavity of beta-CD can encapsulate the steroid part of AACBs while the hydroxyls exposed on the beta-CD surface have strong hydrophilic interactions with the arginine part of AACBs.	Arginine	173-181	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	26-33
35489243-5	2022	The hydrophobic cavity of beta-CD can encapsulate the steroid part of AACBs while the hydroxyls exposed on the beta-CD surface have strong hydrophilic interactions with the arginine part of AACBs.	Arginine	173-181	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-118
35498050-7	2022	Moreover, we demonstrated that L-Arginine significantly attenuates Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells.	Arginine	31-41	angiotensinogen	Homo sapiens	67-81
35498646-13	2022	Additionally, AS pattern change of arginine/serine-rich splicing factor 31(RS31) via TOR pathway, which was previously described in response to light and sucrose signaling, was also induced in a similar manner by both glucose stress and reactive oxygen species (ROS).	Arginine	35-43	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	75-79
35498646-13	2022	Additionally, AS pattern change of arginine/serine-rich splicing factor 31(RS31) via TOR pathway, which was previously described in response to light and sucrose signaling, was also induced in a similar manner by both glucose stress and reactive oxygen species (ROS).	Arginine	35-43	target of rapamycin	Arabidopsis thaliana	85-88
35567118-4	2022	The ORF5 (p10) protein sequence of eight Iranian isolates was compared to other vitiviruses, showing that the most conserved region resides in the N-terminus, carrying an arginine-rich motif followed by a zinc-finger motif.	Arginine	171-179	S100 calcium binding protein A10	Homo sapiens	10-13
35311558-2	2022	The twin-arginine translocation system (Tat) is an important protein export system, playing a critical role in bacterial physiology and pathogenesis.	Arginine	9-17	twin-arginine translocation (TAT) pathway signal sequence domain protein	Escherichia coli	40-43
35302484-2	2022	In the drug combination nirmatrelvir + ritonavir (nirmatrelvir/r), the active agent, nirmatrelvir, is made bioavailable in clinically adequate amounts by the additional administration of a potent inhibitor of its first-pass metabolism by way of cytochrome P450 (CYP) 3A in the gut and liver.	Arginine	63-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	245-269
35422485-9	2022	In addition, exosomal miR-182-5p was found to diminish GSDMD-dependent cell pyroptosis and inflammation induced by H/R.	Arginine	117-118	microRNA 182	Mus musculus	22-29
35114687-9	2022	Its central sulfonylurea group interacts with the Walker A motif of the NLRP3 nucleotide-binding domain and is sandwiched between two arginines, explaining the specificity of NLRP3 for this chemical entity.	Arginine	134-143	NLR family pyrin domain containing 3	Homo sapiens	72-77
35528828-2	2022	There is evidence that glucocorticoids act via negative feedback to suppress arginine-vasopressin secretion.	Arginine	77-85	arginine vasopressin	Homo sapiens	86-97
35142450-7	2022	Longitudinal validation analysis confirms that the ARG score is associated with T2D progression, characterized by the change of insulin resistance.	Arginine	51-54	insulin	Homo sapiens	128-135
35033573-2	2022	PRMT6, namely protein arginine methyltransferase 6, was first identified and demonstrated to catalyze the methylation of arginine residue on the chromatin histones in mammals.	Arginine	121-129	protein arginine methyltransferase 6	Homo sapiens	0-5
35124853-4	2022	For instance, ADP-ribosyltransferase 1 (ART1) catalyzes mono(ADP-ribosyl)ation of arginine residues in Trim72, a protein specifically expressed in muscle cells and involved in cell membrane repair, which is enhanced upon its ADP-ribosylation.	Arginine	82-90	ADP-ribosyltransferase 1	Homo sapiens	14-38
35124853-4	2022	For instance, ADP-ribosyltransferase 1 (ART1) catalyzes mono(ADP-ribosyl)ation of arginine residues in Trim72, a protein specifically expressed in muscle cells and involved in cell membrane repair, which is enhanced upon its ADP-ribosylation.	Arginine	82-90	ADP-ribosyltransferase 1	Homo sapiens	40-44
35114687-9	2022	Its central sulfonylurea group interacts with the Walker A motif of the NLRP3 nucleotide-binding domain and is sandwiched between two arginines, explaining the specificity of NLRP3 for this chemical entity.	Arginine	134-143	NLR family pyrin domain containing 3	Homo sapiens	175-180
35357495-3	2022	An earlier report showed that the sharp decrease in hypocotyl growth rapidly induced by R was accompanied by an equally rapid decrease in the transcript and protein levels of two closely related apyrases (nucleoside triphosphate-diphosphohydrolases) in Arabidopsis (Arabidopsis thaliana), APY1 and APY2, enzymes whose expression alters auxin transport and growth in seedlings.	Arginine	88-89	apyrase 2	Arabidopsis thaliana	298-302
35322764-1	2022	NO, or nitric oxide, is produced by a family of enzymes called nitric oxide synthase (NOS) from L-arginine.	Arginine	96-106	nitric oxide synthase 2	Homo sapiens	63-84
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Arginine	86-94	Ionotropic receptor 25a	Drosophila melanogaster	241-246
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Arginine	86-94	Ionotropic receptor 51b	Drosophila melanogaster	248-253
35176225-7	2022	Furthermore, our findings indicated that ecologically relevant high concentrations of arginine, lysine, proline, valine, tryptophan, isoleucine, and leucine elicit aversive responses via bitter-sensing GRNs, which are mediated by three IRs (IR25a, IR51b, and IR76b).	Arginine	86-94	Ionotropic receptor 76b	Drosophila melanogaster	259-264
35340414-7	2022	KLF4 and miR-155-5p levels were enhanced, and ERRFI1 level was repressed in mice after acute renal allograft and in H/R-treated HK-2 cells.	Arginine	118-119	ERBB receptor feedback inhibitor 1	Mus musculus	46-52
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Arginine	160-170	coagulation factor II thrombin receptor	Homo sapiens	107-109
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Arginine	160-170	mechanistic target of rapamycin kinase	Homo sapiens	122-126
35391841-13	2022	These findings highlight a new mechanism of Rg2-induced cardioprotection: reducing the formation of RIP1/RIP3 necrosome by regulating TAK1 phosphorylation to block necroptosis induced by MI/R.	Arginine	190-191	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	100-104
35370564-1	2022	The protein arginine methyl transferase PRMT5 is an enzyme expressed in oligodendrocyte lineage cells and responsible for the symmetric methylation of arginine residues on histone tails.	Arginine	12-20	protein arginine methyltransferase 5	Homo sapiens	40-45
35340414-12	2022	Knocking down ERRFI1 antagonized the effects of downregulated miR-155-5p on acute renal allograft injury, as well as on H/R-treated HK-2 cell proliferation and apoptosis.	Arginine	122-123	ERBB receptor feedback inhibitor 1	Mus musculus	14-20
35370564-1	2022	The protein arginine methyl transferase PRMT5 is an enzyme expressed in oligodendrocyte lineage cells and responsible for the symmetric methylation of arginine residues on histone tails.	Arginine	151-159	protein arginine methyltransferase 5	Homo sapiens	40-45
35370564-7	2022	This analysis identified a similar number of peptides in the two subcellular fractions and a total number of 57 proteins with statistically decreased symmetric methylation of arginine residues in the CRISPR-PRMT5 knockdown compared to control.	Arginine	175-183	protein arginine methyltransferase 5	Homo sapiens	207-212
35350351-0	2022	Observation of Arginine Side-Chain Motions Coupled to the Global Conformational Exchange Process in Deubiquitinase A.	Arginine	15-23	OTU deubiquitinase 5	Homo sapiens	100-116
34995687-5	2022	In addition, two different ring-opening sites of MC-LR in Ala-Leu and Arg-Adda were observed, and three new anaerobic degradation products were first identified, including two hexapeptides (MeAsp-Arg-Adda-Glu-Mdha-Ala and Adda-Glu-Mdha-Ala-Leu-MeAsp) and one end-product pentapeptide (Glu-Mdha-Ala-Leu-MeAsp).	Arginine	70-73	adducin 1	Homo sapiens	74-78
35249015-7	2022	When tested in association with plasmapheresis, the DDAH-cartridge was highly effective in ADMA removal from the blood and improved the arginine/ADMA ratio in a pig model.	Arginine	136-144	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	52-56
35258696-0	2022	An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation.	Arginine	3-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38
35345315-0	2022	Arginine Promotes the Expression of Aquaporin-3 and Water Transport in Porcine Trophectoderm Cells Through NO- and cAMP-Dependent Mechanisms.	Arginine	0-8	aquaporin 3	Mus musculus	36-47
35345315-5	2022	RESULTS: Arg treatment increased water transport and the expression of AQP3, which was abundantly expressed in pTr2 cells at both the mRNA and protein levels.	Arginine	9-12	aquaporin 3	Mus musculus	71-75
35345315-6	2022	Arg also increased the expression of iNOS and the synthesis of nitric oxide (NO) in pTr2 cells.	Arginine	0-3	nitric oxide synthase 2, inducible	Mus musculus	37-41
35345315-7	2022	The presence of Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME; an inhibitor of NO synthase) significantly attenuated the Arg-induced expression of AQP3.	Arginine	134-137	aquaporin 3	Mus musculus	160-164
35345315-8	2022	Furthermore, 0.50 mM Arg increased the concentrations of cAMP and the abundances of phosphorylated cAMP-dependent protein kinase A (PKA), phosphorylated PKA alpha/beta/gamma, and phosphorylated CREB.	Arginine	21-24	cAMP responsive element binding protein 1	Mus musculus	194-198
34986770-11	2022	CONCLUSION: R-99 and R-123 showed antinociceptive effects related to mechanisms that involve, at least in part, interaction with the opioid and adrenergic systems and TRPV1 pathways.	Arginine	21-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	167-172
35059512-9	2022	As a result, during IUGR, supplementation of Arg or NCG affected intestinal AA profiles in the fetus in part through controlling mTOR signal transduction as well as AA and peptide transport.	Arginine	45-48	mechanistic target of rapamycin kinase	Homo sapiens	129-133
35100360-8	2022	We further identify a physical interaction between ZNF507 and PRMT5, suggesting ZNF507 may target arginine methylation activity to LINE-1 sequences.	Arginine	98-106	protein arginine methyltransferase 5	Homo sapiens	62-67
35345315-10	2022	CONCLUSIONS: The results of this study demonstrate that Arg regulates AQP3 expression and promotes water transport in pTr2 cells through NO- and cAMP-dependent signaling pathways.	Arginine	56-59	aquaporin 3	Mus musculus	70-74
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	caspase 4	Homo sapiens	86-91
35063457-9	2022	DNA sequencing of case2 showed that a heterozygous mutation in exon 8 of the FGG (c.5877G > A) with being responsible for the Arg   His substitution at position 301 of the gamma chain (p. Arg301His).	Arginine	126-129	fibrinogen gamma chain	Homo sapiens	77-80
35190853-0	2022	Inhibition of PRMT6 reduces neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation.	Arginine	103-111	protein arginine methyltransferase 6	Homo sapiens	14-19
35190853-0	2022	Inhibition of PRMT6 reduces neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation.	Arginine	103-111	forkhead box G1	Homo sapiens	97-102
35190853-9	2022	Mechanistic experiments revealed that PRMT6 silencing reduced the arginine methylation level of FoxG1 protein.	Arginine	66-74	protein arginine methyltransferase 6	Homo sapiens	38-43
35190853-9	2022	Mechanistic experiments revealed that PRMT6 silencing reduced the arginine methylation level of FoxG1 protein.	Arginine	66-74	forkhead box G1	Homo sapiens	96-101
35190853-11	2022	CONCLUSION: Our findings suggested that inhibition of PRMT6 reduced neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation.	Arginine	143-151	protein arginine methyltransferase 6	Homo sapiens	54-59
35190853-11	2022	CONCLUSION: Our findings suggested that inhibition of PRMT6 reduced neomycin-induced inner ear hair cell injury through the restraint of FoxG1 arginine methylation.	Arginine	143-151	forkhead box G1	Homo sapiens	137-142
35101441-2	2022	In the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, a number of arginine and lysine side-chains have been shown to be important for Cl- permeation.	Arginine	91-99	CF transmembrane conductance regulator	Homo sapiens	7-58
35101441-2	2022	In the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, a number of arginine and lysine side-chains have been shown to be important for Cl- permeation.	Arginine	91-99	CF transmembrane conductance regulator	Homo sapiens	60-64
35137179-7	2022	Most importantly, an embryonic chimeric assay showed that Prmt1 inhibition and mutated Klf4 at Arg 396 induce the integration of mouse ESCs into the PrE lineage.	Arginine	95-98	Kruppel-like factor 4 (gut)	Mus musculus	87-91
35120671-7	2022	The ProP 1.0 Server, a neural network prediction tool, predicted the presence of a cleavage site at the substituted arginine residue (p.Q44R) of NPPC.	Arginine	116-124	PROP paired-like homeobox 1	Homo sapiens	4-10
34999111-0	2022	Insulin regulates arginine-stimulated insulin secretion in humans.	Arginine	18-26	insulin	Homo sapiens	0-7
34999111-0	2022	Insulin regulates arginine-stimulated insulin secretion in humans.	Arginine	18-26	insulin	Homo sapiens	38-45
34999111-4	2022	MATERIALS AND METHODS: Arginine-stimulated insulin secretion was studied in 10 healthy humans.	Arginine	23-31	insulin	Homo sapiens	43-50
34999111-6	2022	Arginine-stimulated insulin secretion was measured by C-peptide deconvolution, and by a selective immunogenic (DAKO) assay for direct measurement of endogenous but not exogenous insulin.	Arginine	0-8	insulin	Homo sapiens	20-27
34999111-7	2022	RESULTS: Pre-exposure to exogenous insulin augmented arginine-stimulated insulin secretion.	Arginine	53-61	insulin	Homo sapiens	35-42
34999111-7	2022	RESULTS: Pre-exposure to exogenous insulin augmented arginine-stimulated insulin secretion.	Arginine	53-61	insulin	Homo sapiens	73-80
34999111-10	2022	CONCLUSIONS: We demonstrate a physiologic role of insulin in regulation of the beta cell secretory response to arginine.	Arginine	111-119	insulin	Homo sapiens	50-57
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-106
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	nuclear factor, erythroid derived 2, like 2	Mus musculus	186-191
35300428-7	2022	A five ARG-based signature, including A2M, CHEK2, ELN, FOS, and PLAU, was constructed in the TCGA dataset, and stratified patients into low- and high-risk groups with significantly different overall survival (OS) rates.	Arginine	7-10	plasminogen activator, urokinase	Homo sapiens	64-68
35295316-12	2022	HS increases the expression of the cytosolic arginine sensor for mTORC1 subunits 1 and 2, phosphorylation of mammalian target of rapamycin and decreases the phosphorylation of Janus kinase-2 (a signal transducer and activator of transcription factor-5).	Arginine	45-53	mechanistic target of rapamycin kinase	Homo sapiens	109-138
35391922-2	2022	At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite.	Arginine	48-58	nitric oxide synthase 2	Homo sapiens	89-100
35432859-4	2022	Two regions in C2B are essential for the process, the well-known polybasic patch and a recently described pair of arginines (398 399).	Arginine	114-123	secretoglobin family 2B member 3, pseudogene	Homo sapiens	15-18
35194735-7	2022	The effects of miR-27-3p and/or galectin-3 and HIF-1alpha on the inhibition of cell viability and apoptosis induced by H/R were explored.	Arginine	121-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
35391922-2	2022	At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite.	Arginine	123-133	nitric oxide synthase 2	Homo sapiens	89-100
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	heat shock protein family A (Hsp70) member 1A	Homo sapiens	240-246
34996645-6	2022	Comparative analysis showed lactate and fumarate utilization by C. jejuni and C. coli exclusively, whereas ESBL-E. coli rapidly consumed asparagine, glutamine/arginine, lysine, threonine, tryptophan, pyruvate, glycerol, cellobiose, and glucose.	Arginine	159-167	EsbL	Escherichia coli	107-111
35101895-0	2022	Cutting Edge: L-Arginine Transfer from Antigen-Presenting Cells Sustains CD4+ T Cell Viability and Proliferation.	Arginine	14-24	CD4 molecule	Homo sapiens	73-76
35101895-4	2022	Using a coculture system with mycobacterial-specific CD4+ T cells, we show APC L-ARG synthesis supported T cell viability and proliferation, and activated T cells contained APC-derived L-ARG.	Arginine	185-190	CD4 molecule	Homo sapiens	53-56
35177655-8	2022	Heterozygous pathogenic COL4A3 and COL4A4 variants that resulted in a Gly substitution with a highly destabilising residue (Arg, Val, Glu, Asp, Trp) were associated with an increased risk of haematuria (p = 0.018), and those adjacent to a non-collagenous region were associated with a reduced risk (p = 0.046).	Arginine	124-127	collagen type IV alpha 4 chain	Homo sapiens	35-41
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	BAG cochaperone 3	Homo sapiens	292-296
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	calreticulin	Homo sapiens	384-388
35192530-7	2022	RESULTS: TLR-2-Arg polymorphism allele A occurred in 36.7% of the patient group.	Arginine	15-18	toll like receptor 2	Homo sapiens	9-14
35203243-6	2022	We show that EGCG directly binds to the RG/RGG region of fused in sarcoma (FUS) and that arginine methylation enhances this interaction.	Arginine	89-97	FUS RNA binding protein	Homo sapiens	57-73
35203243-6	2022	We show that EGCG directly binds to the RG/RGG region of fused in sarcoma (FUS) and that arginine methylation enhances this interaction.	Arginine	89-97	FUS RNA binding protein	Homo sapiens	75-78
35202090-3	2022	L-arginine availability and its conversion into nitric oxide by nitric oxide synthase 2 (Nos2) or ornithine (a polyamine precursor) by arginase 1/2 regulate macrophage microbicidal activity.	Arginine	0-10	nitric oxide synthase 2, inducible	Mus musculus	89-93
35115608-3	2022	Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center on blocking the WIN site of WDR5, an arginine binding cavity that engages MLL/SET enzymes that deposit histone H3 lysine 4 methylation (H3K4me).	Arginine	130-138	WD repeat domain 5	Homo sapiens	121-125
35069838-7	2022	APPL overexpression-mediated effects were significantly abrogated by compound C. Taken together, the data indicated that APPL1 inhibited ROS production and H/R-induced myocardial injury via the AMPK signaling pathway.	Arginine	158-159	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	194-198
34994982-4	2022	Using ultrahigh-performance liquid time of flight mass spectrometry (UPLC-TOF-MS)-based serum metabolomics and multivariate statistical analysis, we investigated and identified the circulating metabolites L-arginine and arachidonic acid were elevated in trastuzumab-responsive and trastuzumab-resistant HER2-positive breast cancer patients, and increased until reaching their peaks in trastuzumab-resistant HER2-positive breast cancer patients.	Arginine	205-215	erb-b2 receptor tyrosine kinase 2	Homo sapiens	303-307
34994982-4	2022	Using ultrahigh-performance liquid time of flight mass spectrometry (UPLC-TOF-MS)-based serum metabolomics and multivariate statistical analysis, we investigated and identified the circulating metabolites L-arginine and arachidonic acid were elevated in trastuzumab-responsive and trastuzumab-resistant HER2-positive breast cancer patients, and increased until reaching their peaks in trastuzumab-resistant HER2-positive breast cancer patients.	Arginine	205-215	erb-b2 receptor tyrosine kinase 2	Homo sapiens	407-411
34994373-0	2022	A study of lovastatin and L-arginine co-loaded PLGA nanomedicine for enhancing nitric oxide production and eNOS expression.	Arginine	26-36	nitric oxide synthase 3	Homo sapiens	107-111
35163462-2	2022	Previously, we have shown that combination with anti-TCR/anti-TNF-alpha antibody-based therapy re-established normoglycemia and increased proteinic arginine-dimethylation in the spleen, yet not in the pancreas.	Arginine	148-156	tumor necrosis factor	Homo sapiens	62-71
35106510-3	2022	Here, we demonstrate that conferred arginine iminohydrolysis by the bacterial virulence factor and arginine deiminase, arcA, promotes mammalian energy expenditure and insulin sensitivity and reverses dyslipidemia, hepatic steatosis, and inflammation in obese mice.	Arginine	36-44	insulin	Homo sapiens	167-174
35046516-8	2022	The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity, leading to arginine methylation of SREBP1a.	Arginine	79-87	protein arginine methyltransferase 5	Homo sapiens	4-9
35046516-8	2022	The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity, leading to arginine methylation of SREBP1a.	Arginine	79-87	protein arginine methyltransferase 5	Homo sapiens	34-39
35579969-5	2022	Using metabolomics analysis of sera from NTM-PD patients and mouse models, we showed that the levels of l-arginine were decreased in sera from NTM-PD patients and NTM-infected mice.	Arginine	104-114	neurotrimin	Mus musculus	143-146
35092388-8	2022	Insilico analysis of the types of p16 mutations showed mutated, truncated p16 protein having an increased intrinsic disorder, and all the mutations involved truncation post arginine.	Arginine	173-181	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
34974814-0	2022	Prostate-specific membrane antigen modulates the progression of prostate cancer by regulating the synthesis of arginine and proline and the expression of androgen receptors and Fos proto-oncogenes.	Arginine	111-119	folate hydrolase 1	Homo sapiens	0-34
34974814-8	2022	The depletion of PSMA also promoted the biosynthesis of arginine and proline, inhibited the expression of AR and PSA, and induced the expression of c-Fos and FosB.	Arginine	56-64	folate hydrolase 1	Homo sapiens	17-21
35072516-6	2022	The role of a gene variant in Tp53 that modifies proline to arginine was examined using nasal brushings from study participants in the Lovelace Smokers Cohort, primary human AECs, and mice with a modified Tp53 gene.	Arginine	60-68	tumor protein p53	Homo sapiens	30-34
35072516-8	2022	Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure.	Arginine	47-55	tumor protein p53	Homo sapiens	43-46
35579969-6	2022	Oral administration of l-arginine significantly enhanced pulmonary antimicrobial activities with the expansion of IFN-gamma-producing effector T cells and a shift to microbicidal (M1) macrophages in the lungs of NTM-PD model mice.	Arginine	23-33	interferon gamma	Mus musculus	114-123
35579969-6	2022	Oral administration of l-arginine significantly enhanced pulmonary antimicrobial activities with the expansion of IFN-gamma-producing effector T cells and a shift to microbicidal (M1) macrophages in the lungs of NTM-PD model mice.	Arginine	23-33	neurotrimin	Mus musculus	212-215
35579969-7	2022	Mice that received fecal microbiota transplants from l-arginine-treated mice showed increased protective host defense in the lungs against NTM-PD, whereas l-arginine-induced pulmonary host defense was attenuated in mice treated with antibiotics.	Arginine	53-63	neurotrimin	Mus musculus	139-142
35579969-10	2022	Our findings indicate that l-arginine-induced gut microbiota remodeling with enrichment of B. pseudolongum boosts pulmonary immune defense against NTM infection by driving the protective gut-lung axis in vivo.	Arginine	27-37	neurotrimin	Mus musculus	147-150
34100419-4	2022	Consistent with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4 (SRRM4) protein, the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons, RSTS iNeurons show downregulated genes for proteins impacting this network.	Arginine	75-83	serine/arginine repetitive matrix 4	Mus musculus	105-110
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Arginine	95-98	gonadotropin releasing hormone 1	Homo sapiens	27-57
2531657-7	1989	The use of synthetic peptide substrates demonstrated that the amino acid specificity for Lp(a) was arginine rather than lysine.	Arginine	99-107	lipoprotein(a)	Homo sapiens	89-94
2597139-4	1989	In stirred platelets, total and specific inhibition of PMA-induced aggregation by a fibrinogen-derived peptide (RGDS, i.e. Arg-Gly-Asp-Ser) promoted maximal increases in membrane-associated PKC in the presence of PMA and completely prevented the loss in cellular activity.	Arginine	123-126	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
2556391-2	1989	Variant forms of mammalian gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) are present in chicken ([Gln8] GnRH and [His5, Trp7, Tyr8]GnRH), salmon ([Trp7, Leu8]GnRH), and lamprey ([Tyr3, Leu5, Glu6, Trp7, Lys8] GnRH).	Arginine	95-98	gonadotropin releasing hormone 1	Homo sapiens	59-63
2597194-13	1989	Phenylglyoxal, a reagent specific for arginine residues inhibited bull testis PST and both boar phenol sulfotransferases.	Arginine	38-46	sulfotransferase family 1A member 1	Homo sapiens	78-81
2627681-9	1989	With casein diets, the net appearance of arginine reached 97% (CA12) and 82% (CA24).	Arginine	41-49	carbonic anhydrase 12	Sus scrofa	63-67
2568278-4	1989	In the perifusion system using rat hypothalamus, PGE2 (0.28 microM, 2.8 microM), 2-DG (22 mM) and L-arginine (3 mM) stimulated GHRH release from rat hypothalamus.	Arginine	98-108	growth hormone releasing hormone	Rattus norvegicus	127-131
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Arginine	130-133	gonadotropin releasing hormone 1	Homo sapiens	55-92
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	42-46
2681686-1	1989	Endopeptidase (EP) 24.15 cleaves the Tyr5-Gly6 bond of luteinizing hormone-releasing hormone (LHRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), and is the primary LHRH degrading enzyme in pituitary and hypothalamic membrane preparations.	Arginine	130-133	gonadotropin releasing hormone 1	Homo sapiens	94-98
2677400-9	1989	An arginine to threonine mutation at gp120 amino acid 518, the terminal residue of gp120, abolishes both gp160 cleavage and syncytium formation.	Arginine	3-11	glutamyl aminopeptidase	Homo sapiens	105-110
2568278-6	1989	Passive immunization with anti-GHRH serum inhibited the GH secretion induced by icv injection of 5 micrograms PGE2 and by iv infusion of 1 g/kgBW L-arginine in conscious rats.	Arginine	146-156	growth hormone releasing hormone	Rattus norvegicus	31-35
2568278-8	1989	These results suggest that the central effect of PGE2 and peripheral effect of L-arginine to stimulate GH secretion are mediated by hypothalamic GHRH release, and that the inhibitory effect of 2-DG on GH secretion is predominantly mediated by hypothalamic SRIF release rather than GHRH release in rats.	Arginine	79-89	growth hormone releasing hormone	Rattus norvegicus	145-149
2912443-0	1989	Distal His----Arg mutation in bovine myoglobin results in a ligand binding site similar to the abnormal beta site of hemoglobin Zurich (beta 63 His----Arg).	Arginine	14-17	myoglobin	Bos taurus	37-46
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	thyrotropin releasing hormone	Rattus norvegicus	120-123
2912443-1	1989	Carbon monoxide binding to a myoglobin mutant with distal arginine in place of histidine has been examined.	Arginine	58-66	myoglobin	Bos taurus	29-38
2689869-10	1989	The addition of arginine to strains containing the CPA1-lacZ fusion further reduced beta-galactosidase activity of the gcn4 mutant, indicating independent regulation of the CPA1 gene by the general amino acid control and by arginine-specific repression.	Arginine	16-24	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	119-123
2808373-4	1989	Because osteopontin mediates cell adhesion and spreading, and contains an Arg-Gly-Asp-Ser cell-binding sequence, our observations strongly suggest that the cell surface localization of pp69 osteopontin is receptor-mediated, and the modification by phosphorylation may be crucial for its receptor binding activity.	Arginine	74-77	secreted phosphoprotein 1	Rattus norvegicus	190-201
2506948-0	1989	An arginine to cysteine amino acid substitution at a critical thrombin cleavage site in a dysfunctional factor VIII molecule.	Arginine	3-11	coagulation factor VIII	Homo sapiens	104-115
2639680-3	1989	To test this it was exchanged with Ala and Arg by site-directed mutagenesis of the cloned PRC1 gene.	Arginine	43-46	protein regulator of cytokinesis 1	Homo sapiens	90-94
2506948-1	1989	We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and arginine 1689 in the FVIII light chain in a naturally occurring dysfunctional FVIII variant, FVIII Okayama.	Arginine	116-124	coagulation factor VIII	Homo sapiens	136-141
2506948-1	1989	We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and arginine 1689 in the FVIII light chain in a naturally occurring dysfunctional FVIII variant, FVIII Okayama.	Arginine	116-124	coagulation factor VIII	Homo sapiens	136-141
2506948-1	1989	We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and arginine 1689 in the FVIII light chain in a naturally occurring dysfunctional FVIII variant, FVIII Okayama.	Arginine	116-124	coagulation factor VIII	Homo sapiens	136-141
3197838-6	1988	The sequence of bovine angiogenin contains the cell recognition tripeptide Arg-Gly-Asp which is not present in the human protein.	Arginine	75-78	angiogenin	Homo sapiens	23-33
2790181-4	1989	A point mutation that resulted in the substitution of cysteine (TGC) for arginine (CGC) at amino acid 366 was found in exon VIII of one allele of the factor X gene.	Arginine	73-81	cytochrome c oxidase subunit 8A	Homo sapiens	124-128
2506948-1	1989	We have analyzed the factor VIII (FVIII) protein and the nucleotide sequence around two thrombin cleavage sites, at arginine 372 in the FVIII heavy chain and arginine 1689 in the FVIII light chain in a naturally occurring dysfunctional FVIII variant, FVIII Okayama.	Arginine	116-124	coagulation factor VIII	Homo sapiens	136-141
2529542-6	1989	Furthermore, the murine Fc epsilon RII is truncated at the carboxyl terminus and the Arg-Gly-Asp sequence, a common recognition site of integrin receptors, which is found in the reverse configuration in human Fc epsilon RII, is missing.	Arginine	85-88	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	24-38
2529542-6	1989	Furthermore, the murine Fc epsilon RII is truncated at the carboxyl terminus and the Arg-Gly-Asp sequence, a common recognition site of integrin receptors, which is found in the reverse configuration in human Fc epsilon RII, is missing.	Arginine	85-88	Fc epsilon receptor II	Homo sapiens	209-223
2552444-2	1989	Although the Tat sequence contains arginine- and cysteine-rich stretches that are difficult to synthesize, it was possible to prepare pure peptides in good yield by using fluoren-9-ylmethoxycarbonyl (Fmoc) chemistry.	Arginine	35-43	tyrosine aminotransferase	Homo sapiens	13-16
3145192-4	1988	The mutated RAS2 gene in TS1 cells encoded a protein with the glycines at positions 82 and 84 replaced by serine and arginine respectively.	Arginine	117-125	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	12-16
2506948-9	1989	We conclude that the pathogenesis of hemophilia A in this patient is probably due to an arginine to cysteine substitution at a thrombin cleavage site in the FVIII heavy chain.	Arginine	88-96	coagulation factor VIII	Homo sapiens	157-162
2613766-10	1989	Migration over intact FGN was almost totally blocked by 230 microM-Arg-Gly-Asp-Ser (RGDS), a peptide known to interact with integrin-type receptors.	Arginine	67-70	ral guanine nucleotide dissociation stimulator	Homo sapiens	84-88
2674119-7	1989	Site specific mutations within these 5 residues demonstrate that Gly-508 and Arg-509 are independently involved in calmodulin-dependent binding and activation of myosin light chain kinase.	Arginine	77-80	myosin, heavy chain 15	Gallus gallus	162-168
2572523-2	1989	Glucagon release stimulated by 20 mM arginine was significantly enhanced in the IAP-treated rat pancreatic islets as compared with the IAP-untreated controls.	Arginine	37-45	Cd47 molecule	Rattus norvegicus	80-83
2527238-2	1989	Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins.	Arginine	61-64	ral guanine nucleotide dissociation stimulator	Homo sapiens	55-59
2676702-8	1989	Finally, catfish I GnRH is likely to have a lysine or arginine residue as it is the most hydrophilic family member.	Arginine	54-62	gonadotropin releasing hormone 1	Homo sapiens	19-23
3171483-1	1988	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and various cell types, is a 13.8-kD single polypeptide rich in arginine with a calculated isoelectric point (pI) of 10.9.	Arginine	139-147	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	0-38
3171483-1	1988	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and various cell types, is a 13.8-kD single polypeptide rich in arginine with a calculated isoelectric point (pI) of 10.9.	Arginine	139-147	myelin basic protein	Homo sapiens	40-43
2527238-2	1989	Since both ligands bind to it through their respective RGDS (Arg-Gly-Asp-Ser) domains and since both have been cloned, we were able to deduce the amino acid sequence of the binding site from the nucleotide sequence coding for RGDS in both proteins.	Arginine	61-64	ral guanine nucleotide dissociation stimulator	Homo sapiens	226-230
2506441-7	1989	These studies suggest that arginine 42 may be a contact point for TGF-alpha-EGF receptor interaction.	Arginine	27-35	transforming growth factor alpha	Homo sapiens	66-75
2752145-3	1989	Polymerase chain reaction (PCR) amplification of 576 base pairs of exon h (VIII) with cloning and dideoxy sequencing of cloned DNA from one hemophiliac revealed a single C----T transition in codon 338 that changes an arginine residue codon CGA to a nonsense codon TGA.	Arginine	217-225	cytochrome c oxidase subunit 8A	Homo sapiens	75-79
2590469-3	1989	The Mi-VIII-specific glycophorin A was found to exhibit an arginine----threonine exchange at position 49.	Arginine	59-67	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
2907171-6	1988	In contrast, CGRP impaired the plasma insulin responses to both glucose (7 mg/min; P less than 0.001) and arginine (8.5 mg/min; P less than 0.001), and inhibited the arginine-induced increase in plasma glucagon concentrations (P less than 0.001).	Arginine	106-114	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
2907171-6	1988	In contrast, CGRP impaired the plasma insulin responses to both glucose (7 mg/min; P less than 0.001) and arginine (8.5 mg/min; P less than 0.001), and inhibited the arginine-induced increase in plasma glucagon concentrations (P less than 0.001).	Arginine	166-174	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
2489081-5	1989	However in the case of L-arabinose, Arg 151 forms hydrogen bonds with the hydroxyl group at the C-4 atom and the ring oxygen, whereas in case of D-galactose it forms bonds with the hydroxyl groups at the C-4 and C-6 atoms of the pyranose ring.	Arginine	36-39	complement C6	Homo sapiens	212-215
2546924-3	1989	The Gly at position 55 in the Fic protein was changed to Arg in the Fic-1 protein.	Arginine	57-60	Fic	Escherichia coli	30-33
2546924-3	1989	The Gly at position 55 in the Fic protein was changed to Arg in the Fic-1 protein.	Arginine	57-60	Fic	Escherichia coli	68-71
2736258-6	1989	N-terminal and internal sequences derived from the rat tumor-secreted phosphoprotein indicate that it is identical to rat osteopontin, a bone protein with an Arg-Gly-Asp cell-binding sequence (Oldberg, A., Franzen, A. and Heinegard, D. (1986) Proc.	Arginine	158-161	secreted phosphoprotein 1	Rattus norvegicus	122-133
2500436-8	1989	HNP-4 and the defensins have identical cysteine backbones and, like the defensins, HNP-4 is rich in arginine (15.2 mol %).	Arginine	100-108	defensin alpha 4	Homo sapiens	83-88
2525104-3	1989	Here, the ability of the cell-attachment sequence of fibronectin, Arg-Gly-Asp-Ser (RGDS), to promote this process was studied.	Arginine	66-69	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	83-87
2551057-5	1989	Substituting arginine for lysine at the carboxy-terminus or the 17th residue from the carboxy-terminus decreased the affinity of peptides for plasmin 9-fold and 5-fold, respectively, implicating these lysine residues of AP as major ligand sites for plasmin.	Arginine	13-21	plasminogen	Homo sapiens	142-149
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Arginine	191-199	plasminogen	Homo sapiens	161-168
2565905-7	1989	60% of the transported chimera was cleaved at the Arg-Lys processing site in native prosomatostatin yielding "mature" alpha-globin.	Arginine	50-53	hemoglobin subunit alpha 2	Homo sapiens	118-130
2506109-3	1989	There was 1 bp change which would result in the substitution of Ser (TEM-7) for Arg (TEM-2) in amino acid (aa) position 162 (i.e., aa position 139 of the mature enzyme).	Arginine	80-83	RASD family member 2	Homo sapiens	85-90
2712830-1	1989	Fibronectin, von Willebrand factor, and fibrinogen each bind to the glycoprotein IIb-IIIa complex on activated platelets via an arg-gly-asp-ser (RGDS) sequence present within the adhesive proteins.	Arginine	128-131	ral guanine nucleotide dissociation stimulator	Homo sapiens	145-149
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Arginine	44-47	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	103-106
2521674-11	1989	The second change, a substitution of Gln by Arg in ts118 at residue 93 in nsP4, had little apparent phenotype on its own, but in combination with the change in nsP2 led to a ts phenotype.	Arginine	44-47	serine protease 57	Homo sapiens	74-78
2521674-11	1989	The second change, a substitution of Gln by Arg in ts118 at residue 93 in nsP4, had little apparent phenotype on its own, but in combination with the change in nsP2 led to a ts phenotype.	Arginine	44-47	reticulon 2	Homo sapiens	160-164
2497770-18	1989	The Arg-40 derivative had 2.2% ribonucleolytic activity compared with unmodified angiogenin.	Arginine	4-7	angiogenin	Homo sapiens	81-91
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Arginine	44-47	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	184-187
2568278-0	1989	[The effects of PGE2, 2-DG and L-arginine on hypothalamic GHRH and SRIF releases in conscious rats, with respect to GH secretion].	Arginine	31-41	growth hormone releasing hormone	Rattus norvegicus	58-62
2568278-1	1989	The effects of prostaglandin E2 (PGE2), 2-deoxy-D-glucose (2-DG) and L-arginine on hypothalamic GHRH and SRIF release with respect to GH secretion were studied in conscious male rats.	Arginine	69-79	growth hormone releasing hormone	Rattus norvegicus	96-100
2500352-0	1989	Radioimmunoassay for thyrotropin-releasing hormone precursor peptide, Lys-Arg-Gln-His-Pro-Gly-Arg-Arg.	Arginine	94-97	thyrotropin releasing hormone	Rattus norvegicus	21-50
2465036-7	1989	E338-362 is adjacent to an enzymatic cleavage site at arg-372 which is important in F.VIII activation.	Arginine	54-57	coagulation factor VIII	Homo sapiens	84-90
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Arginine	81-84	thyrotropin releasing hormone	Rattus norvegicus	23-52
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Arginine	81-84	thyrotropin releasing hormone	Rattus norvegicus	110-117
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Arginine	101-104	thyrotropin releasing hormone	Rattus norvegicus	23-52
2500352-1	1989	A radioimmunoassay for thyrotropin-releasing hormone (TRH) precursor peptide Lys-Arg-Gln-His-Pro-Gly-Arg-Arg (pro-TRH), has been developed.	Arginine	101-104	thyrotropin releasing hormone	Rattus norvegicus	110-117
2917185-5	1989	Addition of the peptides Arg-Gly-Asp-Ser (RGDS) and fibrinogen gamma-chain carboxyl-terminal (gamma 397-411) at concentrations sufficient to completely block fibrinogen binding to GP IIb-IIIa had no effect on either C5b-9 induced dense granule secretion or the associated turbidity change.	Arginine	25-28	ral guanine nucleotide dissociation stimulator	Homo sapiens	42-46
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Arginine	108-111	thyrotropin releasing hormone	Rattus norvegicus	5-12
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Arginine	108-111	thyrotropin releasing hormone	Rattus norvegicus	84-91
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Arginine	128-131	thyrotropin releasing hormone	Rattus norvegicus	5-12
2500352-2	1989	Anti-pro-TRH antibody was raised in rabbits immunized with a conjugate of synthetic pro-TRH analog, Cys-Lys-Arg-Gln-His-Pro-Gly-Arg-Arg-Cys (pCC10) to bovine serum albumin.	Arginine	128-131	thyrotropin releasing hormone	Rattus norvegicus	84-91
2466844-4	1989	Amino acid analyses of C-8 revealed low Arg (7 residue % in C-8 compared to 11-12 residue % in C-1) and increased Glx residues.	Arginine	40-43	homeobox C8	Homo sapiens	23-26
2624182-1	1989	We have cloned and sequenced a full length cDNA for HPRT cDNA for HPRTYale isolated from Lesch-Nyhan subject and identified a single nucleotide substitution which results in amino acid substitution of glycine to arginine.	Arginine	212-220	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	52-56
2910912-2	1989	One peptide (HHLGGAKQAGDV) corresponds to the carboxyl terminal segment of the fibrinogen gamma-chain (gamma 400-411) and the other (RGDS) contains the amino acid sequence Arg-Gly-Asp (RGD) common to fibronectin, von Willebrand factor, vitronectin and the alpha-chain of fibrinogen.	Arginine	172-175	ral guanine nucleotide dissociation stimulator	Homo sapiens	133-137
2466844-13	1989	Since the substitution of citrulline for Arg would generate several relatively long apolar sequences, these would enhance the ability of C-8 to interact with the hydrophobic lipophilin molecule, promoting vesicle aggregation by hydrophobic interactions.	Arginine	41-44	homeobox C8	Homo sapiens	137-140
2721567-1	1989	L-365,260 (3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl)-N"-(3-methylphenyl)urea), interacted in a stereoselective and competitive manner with guinea pig stomach gastrin and brain cholecystokinin (CCK) receptors.	Arginine	0-2	gastrin	Cavia porcellus	189-196
2739846-5	1989	C3ades Arg and C5ades Arg were increased after 15 min of dialysis; this was accompanied by transient but significant reductions in PMN count and phagocytosis and increased CR3 expression.	Arginine	22-25	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	172-175
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Arginine	39-47	heme oxygenase 2	Homo sapiens	83-86
2492791-20	1989	It appears that the positive charge of arginine-143 plays a role in the binding of HO2- at the active site of human Cu,ZnSOD, and that replacement of the arginine by lysine gives an enzyme with a similar affinity mechanism of inactivation, but with a greatly reduced affinity for HO2-.	Arginine	39-47	heme oxygenase 2	Homo sapiens	280-283
2902089-8	1988	In the absence of ligands (likely to represent the E1 conformation), trypsin cleaved the 100-kDa ATPase polypeptide at three sites very near the N terminus: Lys-24, Lys-36, and Arg-73.	Arginine	177-180	dynein axonemal heavy chain 8	Homo sapiens	97-103
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Arginine	131-134	thyrotropin releasing hormone	Rattus norvegicus	16-19
3052449-3	1988	These data are consistent with the presence of proteolytic activity in the insulin receptor specific for the bonds whose carbonyl functions are provided by arginine but not by lysine.	Arginine	156-164	insulin receptor	Rattus norvegicus	75-91
2497688-4	1989	To identify the TRH precursor in the rat hypothalamus, an antiserum was raised against the synthetic decapeptide sequence, Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys.	Arginine	155-158	thyrotropin releasing hormone	Rattus norvegicus	16-19
3150544-2	1988	One of these new derivatives, FVIII delta II, in which amino acids 771(pro)-1666(asp) have been deleted, no longer contains the protease cleavage site at amino acid position 1648(arg)-1649(glu) known to be involved in the initial step of FVIII processing.	Arginine	179-182	coagulation factor VIII	Homo sapiens	30-35
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Arginine	48-51	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
3421963-0	1988	Conserved amino acid residues arginine 33 and tyrosine 123 are critical for the antiviral activity of murine interferon-alpha 1.	Arginine	30-38	interferon alpha 1	Mus musculus	109-127
3421963-4	1988	These analogues demonstrate the importance of the conserved residues arginine 33 and tyrosine 123 in maintaining the antiviral activity of murine interferon-alpha 1.	Arginine	69-77	interferon alpha 1	Mus musculus	146-164
2903866-0	1988	Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	20-34
3196699-8	1988	Arginine and lysine at low concentrations slightly accelerate GFAP assembly, but above 100 mM both amino acids inhibit assembly.	Arginine	0-8	glial fibrillary acidic protein	Bos taurus	62-66
2903866-1	1988	To determine how arginine (Arg) stimulates GH secretion, we investigated its interaction with GHRH in vivo and in vitro.	Arginine	17-25	growth hormone releasing hormone	Rattus norvegicus	94-98
2903866-7	1988	After GHRH-Arg-TRH, the maximal serum GH level was significantly higher (72.7 +/- 13.4 micrograms/L) than that after Arg-TRH alone, whereas serum TSH and PRL increased to comparable levels (TSH, 10.2 +/- 3.0 mU/L; PRL, 64.4 +/- 13.6 micrograms/L).	Arginine	11-14	growth hormone releasing hormone	Rattus norvegicus	6-10
3410851-2	1988	All the identified cleavages occurred either COOH-terminal to or between pairs of basic amino acids, with plasma kallikrein recognizing Lys-Lys, Lys-Arg, and Arg-Arg as processing signals.	Arginine	149-152	kallikrein B1	Homo sapiens	106-123
3410851-2	1988	All the identified cleavages occurred either COOH-terminal to or between pairs of basic amino acids, with plasma kallikrein recognizing Lys-Lys, Lys-Arg, and Arg-Arg as processing signals.	Arginine	158-161	kallikrein B1	Homo sapiens	106-123
2903866-7	1988	After GHRH-Arg-TRH, the maximal serum GH level was significantly higher (72.7 +/- 13.4 micrograms/L) than that after Arg-TRH alone, whereas serum TSH and PRL increased to comparable levels (TSH, 10.2 +/- 3.0 mU/L; PRL, 64.4 +/- 13.6 micrograms/L).	Arginine	117-120	growth hormone releasing hormone	Rattus norvegicus	6-10
2903866-12	1988	Our results indicate that Arg administered with GHRH led to higher serum GH levels than did a maximally stimulatory dose of GHRH or Arg alone.	Arginine	26-29	growth hormone releasing hormone	Rattus norvegicus	48-52
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Arginine	48-51	ral guanine nucleotide dissociation stimulator	Homo sapiens	65-69
2456309-3	1988	After treatment with pyroglutamyl aminopeptidase, N-terminal sequencing indicated that Gln74 of MBP formed the N-terminal residue of peptide C. A rabbit antiserum was raised to a synthetic peptide containing the sequence Pyroglu-Lys-Ser-His-Gly-Arg, corresponding to the first six residues of peptide C. By immunoblotting this serum reacted with peptide C but not with intact MBP.	Arginine	245-248	myelin basic protein	Homo sapiens	96-99
2460346-1	1988	An antibody population recognizing the sequence Arg-Gly-Asp-Ser (RGDS) in fibronectin, anti-(RGDS)N, was isolated by immunoadsorption.	Arginine	48-51	ral guanine nucleotide dissociation stimulator	Homo sapiens	93-97
3221868-13	1988	Surf-3 specifies a highly expressed 1.0-kilobase mRNA that contains a long open reading frame of 266 amino acids, which would encode a highly basic polypeptide (23% Arg plus Lys).	Arginine	165-168	ribosomal protein L7A	Mus musculus	0-6
3403546-4	1988	The deduced amino acid sequence of cofilin is 166 residues long and contains a sequence of Lys-Lys-Arg-Lys-Lys which is very similar to the nuclear transport signal sequence (Pro-Lys-Lys-Lys-Arg-Lys-Val) of SV40 large T antigen.	Arginine	99-102	cofilin 1	Homo sapiens	35-42
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Arginine	196-204	glutathione-disulfide reductase	Homo sapiens	150-171
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Arginine	215-218	glutathione-disulfide reductase	Homo sapiens	150-171
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Arginine	215-218	pseudouridine 5'-phosphatase	Homo sapiens	297-300
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Arginine	226-229	glutathione-disulfide reductase	Homo sapiens	150-171
3167026-8	1988	A search for the amino acid residues in the primary sequence of trypanothione reductase functionally active in binding/catalysis in human erythrocyte glutathione reductase shows that only the two arginine residues (Arg-37 and Arg-347), shown by X-ray crystallographic data to hydrogen bond to the GS1 glutathione glycyl carboxylate, are absent.	Arginine	226-229	pseudouridine 5'-phosphatase	Homo sapiens	297-300
3187957-6	1988	Shear-induced platelet aggregation was inhibited by monoclonal antibody to GPIIb/IIIa (1 microgram/ml) and synthetic peptide, Arg-Gly-Asp-Ser (RGDS) (1 mM).	Arginine	126-129	ral guanine nucleotide dissociation stimulator	Homo sapiens	143-147
3382640-2	1988	In addition, an 18 amino acid peptide, aFGF(123-140), is generated, identifying one of the thrombin cleavage sites as the Arg-122/Thr-123 bond.	Arginine	122-125	fibroblast growth factor 1	Bos taurus	39-43
3294332-0	1988	Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.	Arginine	45-48	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-31
2894984-9	1988	Apart from proteolytic changes in the structure of PrP, we found a novel, as yet unidentified, amino-acid derivative of the arginine residue at position 3 in mouse PrP, which may predispose PrP to form SAF.	Arginine	124-132	prion protein	Mus musculus	164-167
2894984-9	1988	Apart from proteolytic changes in the structure of PrP, we found a novel, as yet unidentified, amino-acid derivative of the arginine residue at position 3 in mouse PrP, which may predispose PrP to form SAF.	Arginine	124-132	phosphatidylglycerophosphate synthase 1	Mus musculus	202-205
3169039-6	1988	The formation of both neurite classes on either pFN or CTB was completely inhibited by low concentrations of an RGDS (Arg-Gly-Asp-Ser) peptide in the medium of cultures, indicating the significance of pFN"s binding to cell surface integrin or ganglioside GM1"s possible interaction with integrin for mediating the differentiative process.	Arginine	118-121	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
3287376-2	1988	A pol1 temperature-sensitive mutation, encoding a DNA-polymerase-primase complex with altered stability, has a single base-pair substitution that changes the glycine at position 493 to a positively charged arginine.	Arginine	206-214	DNA-directed DNA polymerase alpha catalytic subunit POL1	Saccharomyces cerevisiae S288C	2-6
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Arginine	83-91	plasminogen	Homo sapiens	62-69
2852359-5	1988	This suggests that postsecretory processing of CLIP may involve removal of the N-terminal Arg residue.	Arginine	90-93	pro-opiomelanocortin-alpha	Mus musculus	47-51
3044690-9	1988	The presence of arginines in glutathione reductase which is inactivated by phenyl glyoxal, is likely to be responsible for the NADPH-activity of glutathione reductase.	Arginine	16-25	glutathione-disulfide reductase	Homo sapiens	29-50
3044690-9	1988	The presence of arginines in glutathione reductase which is inactivated by phenyl glyoxal, is likely to be responsible for the NADPH-activity of glutathione reductase.	Arginine	16-25	glutathione-disulfide reductase	Homo sapiens	145-166
3291387-0	1988	The arginine-stimulated insulin response is impaired in congenital duck hepatitis B virus infection.	Arginine	4-12	insulin	Anas platyrhynchos	24-31
2832354-1	1988	Neuronal spherical bodies, rich in arginine, of catecholamine neurons in man display staining reactions of mitotic chromosomes and myelin basic protein.	Arginine	35-43	myelin basic protein	Homo sapiens	131-151
3275655-5	1988	It hydrolyzes synthetic substrates at carbonyl bonds of Arg or Lys residues, and the hydrolysis is strongly inhibited by diisopropylfluorophosphate, phenylmethanesulfonyl fluoride, and leupeptin, suggesting that it is a trypsin-like protease.	Arginine	56-59	trypsin-like protease	Bombyx mori	220-241
3291387-4	1988	However, the magnitude of the second phase of the biphasic arginine-stimulated insulin response was markedly diminished in infected ducks.	Arginine	59-67	insulin	Anas platyrhynchos	79-86
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Arginine	198-201	insulin receptor	Homo sapiens	30-46
2458016-0	1988	Enzymatic methylation of arginine residue in myelin basic protein.	Arginine	25-33	myelin basic protein	Homo sapiens	45-65
3398701-10	1988	These results suggest that GEt may be synthesized from Arg and EA by a transamidinase catalyzing reaction.	Arginine	55-58	glycine amidinotransferase	Rattus norvegicus	71-85
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Arginine	206-209	insulin receptor	Homo sapiens	30-46
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Arginine	206-209	insulin receptor	Homo sapiens	30-46
2826158-4	1987	Modification of arginine residues by 1,2-cyclohexanedione had no effect of the stimulation of the phosphodiesterase but reduced by 40% the stimulation of the erythrocyte Ca2+ ATPase.	Arginine	16-24	carbonic anhydrase 2	Bos taurus	170-181
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Arginine	83-86	ubiquitin	Saccharomyces cerevisiae S288C	132-141
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Arginine	206-209	insulin receptor	Homo sapiens	30-46
2826431-8	1987	The 1H NMR spectrum of peaks representing amide hydrogens of the carboxyl-terminal Arg-74, Gly-75, and Gly-76 of the processed mono-ubiquitin was identical with that of human ubiquitin.	Arginine	83-86	ubiquitin	Saccharomyces cerevisiae S288C	175-184
3283938-1	1988	A point mutation in the human insulin receptor gene in a patient with type A insulin resistance alters the amino acid sequence within the tetrabasic processing site of the proreceptor molecule from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser.	Arginine	206-209	insulin receptor	Homo sapiens	30-46
2966812-5	1988	The cytoadhesive tetrapeptide portion of fibronectin, Arg-Gly-Asp-Ser (250-1,000 micrograms/ml), released 1.94 +/- 0.10 micrograms/ml of elastase from 10(7) neutrophils, in contrast to the lack of release by the control hexapeptide, Arg-Gly-Tyr-Ser-Leu-Gly.	Arginine	54-57	elastase, neutrophil expressed	Homo sapiens	137-145
3427074-9	1987	These studies indicate that elastases 2 and elastase 1 both contain an Arg-65A as well as a basic dipeptide at 223/224 which is not present in chymotrypsins.	Arginine	71-74	chymotrypsin like elastase 3A	Homo sapiens	44-54
3688881-4	1987	Kapp, the second-order rate constant of enzyme inactivation by Z-Phe-Phe-CHN2 with LE as substrate was 31,530 M-1 s-1 or 10(3) higher than its effect on cathepsin B-mediated hydrolysis of ME-Arg-Phe at the Met-Arg site.	Arginine	191-194	chimerin 2	Rattus norvegicus	73-77
3678488-5	1987	Here again, this peptide, occupying positions 597-653 and located at the COOH-terminal region of chromogranin B, could derive from specific processing at basic amino acids, Arg-Lys-Lys, present at positions 594-596.	Arginine	173-176	chromogranin B	Homo sapiens	97-111
2964446-9	1988	Thus synthesis and maturation of the alpha-chain of beta-hexosaminidase includes two major proteolytic cleavages: the first, between alanine 22 and leucine 23, removes the signal peptide to generate the precursor form, whereas the second occurs between the dibasic amino acids, lysine 86 and arginine 87.	Arginine	292-300	O-GlcNAcase	Homo sapiens	52-71
2950119-2	1987	To determine if the minimum cellular adhesion receptor recognition signal Arg-Gly-Asp-Ser (RGDS) is sufficient to promote FC and MFB formation, rat (NRK), hamster (Nil 8), and mouse (Balb/c 3T3) fibroblasts in serum-free media were plated on substrates derivatized with small synthetic peptides containing RGDS.	Arginine	74-77	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	91-95
2894984-9	1988	Apart from proteolytic changes in the structure of PrP, we found a novel, as yet unidentified, amino-acid derivative of the arginine residue at position 3 in mouse PrP, which may predispose PrP to form SAF.	Arginine	124-132	prion protein	Mus musculus	164-167
2949744-0	1987	Arginine modification with butanedione inhibits the potassium ATPase of Streptococcus faecalis.	Arginine	0-8	ATPase	Enterococcus faecalis	62-68
2949744-1	1987	The K+-ATPase of Streptococcus faecalis is inhibited by incubation with the arginine-modifying reagent 2,3-butanedione.	Arginine	76-84	ATPase	Enterococcus faecalis	7-13
3113515-5	1987	However, PAI-1 could be extracted from ECM by treatment with either arginine (0.5 mol/L) or potassium thiocyanate (2 mol/L), or by incubation under acidic conditions (pH 2.5).	Arginine	68-76	serpin family E member 1	Bos taurus	9-14
2832737-2	1988	The mutation converted a CGA arginine codon to a TGA nonsense codon and generated a protein of 188 amino acids, instead of the usual 248 amino acids.	Arginine	29-37	T-box transcription factor 1	Homo sapiens	49-52
2958484-6	1987	These reagents are (a) a soluble synthetic tetrapeptide Arg-Gly-Asp-Ser (RGDS; Pierschbacher, M. D., and E. Ruoslahti, 1984, Nature (Lond.	Arginine	56-59	ral guanine nucleotide dissociation stimulator	Homo sapiens	73-77
3539926-2	1987	Here we describe the isolation and characterization of an ompR mutation, a single-base-pair change, that results in an Arg-to-Cys substitution.	Arginine	119-122	two-component system response regulator OmpR	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	58-62
2900718-7	1988	We also found a novel, as yet unidentified, amino acid derivative of the arginine residue at position 3 in both hamster and mouse PrP 33-35, which may predispose PrP to form SAF.	Arginine	73-81	prion protein	Mus musculus	130-133
3023666-5	1986	The latter mutant was able to phosphorylate the kinase-inactive p37mos(Arg-121) protein in vitro.	Arginine	71-74	nucleoporin 37	Homo sapiens	64-67
3023666-6	1986	These results indicate that even though p37mos(Arg-121) can be phosphorylated in trans by other kinase molecules, it lacks the ability to phosphorylate itself in vitro.	Arginine	47-50	nucleoporin 37	Homo sapiens	40-43
2900718-7	1988	We also found a novel, as yet unidentified, amino acid derivative of the arginine residue at position 3 in both hamster and mouse PrP 33-35, which may predispose PrP to form SAF.	Arginine	73-81	prion protein	Mus musculus	162-165
2900718-7	1988	We also found a novel, as yet unidentified, amino acid derivative of the arginine residue at position 3 in both hamster and mouse PrP 33-35, which may predispose PrP to form SAF.	Arginine	73-81	phosphatidylglycerophosphate synthase 1	Mus musculus	174-177
3301854-5	1987	We have found that actins containing Arg or Tyr at position 73 undergo amino-terminal processing, bind to DNase I-agarose, and become incorporated into the cytoskeleton of a nonmuscle cell as efficiently as wild type actin.	Arginine	37-40	deoxyribonuclease-1	Oryctolagus cuniculus	106-113
2472003-5	1988	The sequence shared by the otherwise unrelated DR1 and DR4 haplotypes from residue 67 in the DR a chain that appears to confer susceptibility is Leu-X-X-Gln-Arg/Lys.	Arginine	157-160	down-regulator of transcription 1	Homo sapiens	47-50
3036276-1	1987	Human fibrinogen has an Arg-Gly-Asp-Ser (RGDS) sequence at residues 572-575 of its A alpha-chain.	Arginine	24-27	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
3535793-2	1986	Insulin release from statically incubated HIT-T15 cells was maximally stimulated by glucose, L-arginine and L-leucine.	Arginine	93-103	insulin	Mesocricetus auratus	0-7
3535793-3	1986	L-arginine stimulated insulin release in the absence of glucose.	Arginine	0-10	insulin	Mesocricetus auratus	22-29
2423274-2	1986	Arginine (0.5 g/kg body weight infused over 30 min) resulted in transient highly significant increases in urinary albumin (p less than 0.001), beta 2-microglobulin (p less than 0.001) and N-acetyl-beta-D-glucosaminidase [NAG] (p less than 0.001).	Arginine	0-8	O-GlcNAcase	Homo sapiens	188-219
2423274-2	1986	Arginine (0.5 g/kg body weight infused over 30 min) resulted in transient highly significant increases in urinary albumin (p less than 0.001), beta 2-microglobulin (p less than 0.001) and N-acetyl-beta-D-glucosaminidase [NAG] (p less than 0.001).	Arginine	0-8	O-GlcNAcase	Homo sapiens	221-224
2956269-4	1987	The RGDS tetrapeptide (arg-gly-asp-ser) from the cell attachment domain of fibronectin can specifically block attachment and outgrowth on both fibronectin- and laminin-coated substrates.	Arginine	23-26	ral guanine nucleotide dissociation stimulator	Homo sapiens	4-8
3439594-2	1987	The investigation is concerned with the short-term effect of growth hormone, which can be stimulated by arginine (0.6 g/kg body weight), on potassium concentrations in rats and patients with cerebral death.	Arginine	104-112	gonadotropin releasing hormone receptor	Rattus norvegicus	61-75
3118352-1	1987	Effects were examined of inanition, dietary aflatoxin (2.5 mg/kg), and dietary supplements of threonine, lysine, and arginine on the activities of renal arginase and hepatic ornithine decarboxylase and on the accumulation of polyamines in liver and brain of 24 or 26-day-old broiler cockerels.	Arginine	117-125	ornithine decarboxylase 1	Homo sapiens	174-197
2885032-1	1987	Dipeptidyl peptidase IV (EC 3.4.14.5) was solubilized from rat liver plasma membranes with sulphobetaine 14 and purified by successive affinity chromatography on Con A-Sepharose, wheat germ lectin-Sepharose and arginine-Sepharose columns.	Arginine	211-219	dipeptidylpeptidase 4	Rattus norvegicus	0-23
3555624-2	1987	Its amino acid composition was determined and found to be very similar to that of the nonspecific lipid transfer protein from bovine and rat liver with, as main feature, the absence of arginine, histidine and tyrosine.	Arginine	185-193	sterol carrier protein 2	Homo sapiens	86-120
3108235-0	1987	Creation of a test plasmid for detecting G-C-to-T-A transversions by changing serine to arginine in the active site of beta-lactamase.	Arginine	88-96	beta-lactamase	Escherichia coli	119-133
3108235-1	1987	Oligonucleotide-directed mutagenesis of the beta-lactamase gene, bla, on pBR322 was used to change the codon for the active-site serine 70, AGC, to CGC, coding for arginine.	Arginine	164-172	beta-lactamase	Escherichia coli	44-58
3108235-1	1987	Oligonucleotide-directed mutagenesis of the beta-lactamase gene, bla, on pBR322 was used to change the codon for the active-site serine 70, AGC, to CGC, coding for arginine.	Arginine	164-172	beta-lactamase	Escherichia coli	65-68
3908623-7	1985	Immunocytochemistry, using well characterized antisera to alpha-neoendorphin and met-enkephalin-Arg-Gly-Leu, demonstrated that the prodynorphin and proenkephalin products were present in the same cells in the medulla region of the gland.	Arginine	96-99	proenkephalin-A	Cavia porcellus	148-161
2866513-6	1985	Polyarginine and polyethylenimine also supported CAP2 phosphorylation, but arginine and lysine were ineffective.	Arginine	4-12	cyclase associated actin cytoskeleton regulatory protein 2	Bos taurus	49-53
4084504-9	1985	All of the methylated arginine residues in protein C23, the 34-kilodalton protein, and myelin basic protein [Carnegie, P.R.	Arginine	22-30	nucleolin	Homo sapiens	51-54
4056036-2	1985	The peptides, HNP-1, HNP-2, and HNP-3, which we have termed defensins, were rich in cystine, arginine, and aromatic residues, but were devoid of free sulfhydryl groups and carbohydrate moieties.	Arginine	93-101	defensin alpha 3	Homo sapiens	32-37
2998332-2	1985	The amino acid composition of caldesmon is distinct from that of myosin light-chain kinase and is characterized by a very high glutamic acid content (25.5%), high contents of lysine (13.6%) and arginine (10.3%), and a low aromatic amino acid content (2.4%).	Arginine	194-202	caldesmon 1	Gallus gallus	30-39
3929378-1	1985	A rabbit antiserum to a peptide sequence present in the precursor for thyrotropin-releasing hormone (proTRH), deduced from cloned amphibian-skin complementary DNA, was raised by immunization with the synthetic decapeptide Cys-Lys-Arg-Gln-His-Pro-Gly-Lys-Arg-Cys (proTRH-SH).	Arginine	230-233	thyrotropin releasing hormone	Rattus norvegicus	70-99
2862917-1	1985	Kinetic studies of pig kidney dipeptidyl peptidase IV (dipeptidyl-peptide hydrolase, EC 3.4.14.5) were carried out using substrates possessing a side-chain of different length at the P2 position (or amino-terminal position in this case) such as Lys-, Arg-, Phe-, Met-, Ser-, His-, Glu- and Gly-Pro-pNA.	Arginine	251-254	dipeptidyl peptidase 4	Sus scrofa	30-53
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Arginine	16-19	myelin basic protein	Homo sapiens	58-78
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Arginine	16-19	myelin basic protein	Homo sapiens	80-83
2412548-3	1985	The peptide Gly-Arg-Ala-Ser-Asp-Tyr-Lys-Ser, derived from myelin basic protein (MBP), is part of an epitope to monoclonal antibodies to human MBP.	Arginine	16-19	myelin basic protein	Homo sapiens	142-145
3928667-2	1985	Limited tryptic digestion cleaved human apohemopexin after Arg-216 into half molecules and the N-terminal half was degraded very rapidly, whereas heme-saturated hemopexin was cleaved after Lys-101.	Arginine	59-62	hemopexin	Homo sapiens	43-52
2985446-2	1985	We report here that in frog and mouse pars intermedia cells, newly synthesized [3H]Arg-labeled POMC is associated with the secretory granule membrane prior to processing.	Arginine	83-86	pro-opiomelanocortin-alpha	Mus musculus	95-99
3886397-6	1985	The infusion of arginine did induce an increase in PP level, which reached a statistically significant maximum at 90 min.	Arginine	16-24	pancreatic polypeptide	Homo sapiens	51-53
3886397-8	1985	Thus, the results confirm the finding that arginine stimulates PP secretion in vivo and that pirenzepine reduces the basal level of the hormone, whereas it did not appear to affect the response to arginine.	Arginine	43-51	pancreatic polypeptide	Homo sapiens	63-65
2827766-3	1987	By contrast, 60-min treatment of the oocytes with 1-MeAde was required for maximal activation of two kinases, each of which phosphorylated a synthetic peptide, Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala (RRLSSLRA), patterned after a phosphorylation site sequence from ribosomal protein S6.	Arginine	160-163	ribosomal protein S6	Homo sapiens	257-277
3294787-11	1987	Using in vitro oligonucleotide-directed mutagenesis, we constructed a new signal sequence mutant in which Asp was substituted for Arg at the -3 position of an otherwise wild-type MBP signal peptide.	Arginine	130-133	myelin basic protein	Mus musculus	179-182
2827766-3	1987	By contrast, 60-min treatment of the oocytes with 1-MeAde was required for maximal activation of two kinases, each of which phosphorylated a synthetic peptide, Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala (RRLSSLRA), patterned after a phosphorylation site sequence from ribosomal protein S6.	Arginine	164-167	ribosomal protein S6	Homo sapiens	257-277
2827766-3	1987	By contrast, 60-min treatment of the oocytes with 1-MeAde was required for maximal activation of two kinases, each of which phosphorylated a synthetic peptide, Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala (RRLSSLRA), patterned after a phosphorylation site sequence from ribosomal protein S6.	Arginine	164-167	ribosomal protein S6	Homo sapiens	257-277
3693395-9	1987	Substitution of either an acidic (aspartate) or a "helix-breaking" (glycine) amino acid residue for arginine 23 of the leader inhibits formation of both iOTC and OTC, without affecting translocation.	Arginine	100-108	ornithine transcarbamylase	Rattus norvegicus	154-157
2437423-1	1987	We have investigated the effect of galanin infusion on unstimulated pancreatic polypeptide (PP) release as well as on the PP response to arginine by the perfused rat pancreas.	Arginine	137-145	pancreatic polypeptide	Rattus norvegicus	122-124
2437423-3	1987	Addition of arginine to the perfusate evoked a biphasic pattern of PP release; the second phase of this PP response was delayed when galanin was simultaneously infused.	Arginine	12-20	pancreatic polypeptide	Rattus norvegicus	67-69
2437423-3	1987	Addition of arginine to the perfusate evoked a biphasic pattern of PP release; the second phase of this PP response was delayed when galanin was simultaneously infused.	Arginine	12-20	pancreatic polypeptide	Rattus norvegicus	104-106
3122207-0	1987	Ribonucleolytic activity of angiogenin: essential histidine, lysine, and arginine residues.	Arginine	73-81	angiogenin	Homo sapiens	28-38
2950769-6	1987	In another experiment, a 30-min infusion of L-arginine (13 mg-1 X kg body wt-1 X min iv) in normal fasted rabbits produced a rapid (10 min) increase in plasma insulin and glucagon and a return to base-line levels 60 min after withdrawing the arginine stimulus.	Arginine	44-54	insulin	Oryctolagus cuniculus	159-166
2950769-6	1987	In another experiment, a 30-min infusion of L-arginine (13 mg-1 X kg body wt-1 X min iv) in normal fasted rabbits produced a rapid (10 min) increase in plasma insulin and glucagon and a return to base-line levels 60 min after withdrawing the arginine stimulus.	Arginine	46-54	insulin	Oryctolagus cuniculus	159-166
3122207-2	1987	Reagents specific for histidine, lysine, and arginine markedly decrease the ribonucleolytic activity of angiogenin, much as has been observed for RNase A.	Arginine	45-53	angiogenin	Homo sapiens	104-114
3122207-6	1987	Arginine reagents, on the other hand, inactivate angiogenin considerably faster than RNase A.	Arginine	0-8	angiogenin	Homo sapiens	49-59
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Arginine	145-148	troponin I, fast skeletal muscle	Oryctolagus cuniculus	74-77
3024151-0	1986	Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.	Arginine	85-88	cysteine-rich secretory protein 3	Rattus norvegicus	42-54
3024151-0	1986	Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.	Arginine	85-88	secreted phosphoprotein 1	Rattus norvegicus	56-67
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Arginine	189-192	troponin I, fast skeletal muscle	Oryctolagus cuniculus	74-77
3024151-9	1986	The results show that the Arg-Gly-Asp sequence also confers cell-binding properties on bone-specific sialoprotein.	Arginine	26-29	cysteine-rich secretory protein 3	Rattus norvegicus	101-113
3433275-6	1987	The present results suggest that in patients with hyperargininemia other factors such as arginine and its metabolites including GVA, GAA, ArgA and homoarginine may cause the neurological symptoms.	Arginine	55-63	alpha glucosidase	Homo sapiens	133-136
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	75-78	insulin receptor	Homo sapiens	31-47
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	83-86	insulin receptor	Homo sapiens	31-47
2954262-1	1987	The relationship between chemical modifications of arginine derivatives and inhibitory activity to trypsin, plasmin and glandular kallikrein was investigated comparing with that of thrombin and concluded as follows: The hydrophobic binding pocket, which has been reported previously to be stereogeometrically very similar in trypsin and thrombin, corresponded to the length of ethylpiperidine.	Arginine	51-59	plasminogen	Homo sapiens	108-115
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	83-86	insulin receptor	Homo sapiens	31-47
3732418-5	1986	In human gamma-crystallins, a major structural difference, the replacement of an arginine by a cysteine, occurs in one of the four-fold repeated folded hairpins, which may affect stability.	Arginine	81-89	crystallin gamma S	Bos taurus	9-26
3579863-5	1987	Amino acid sequencing of this peptide revealed that the Arg residue at position 124, as predicted from the cDNA sequence of ADH in DBA/2J mice, has been replaced by Leu in the Danish variant.	Arginine	56-59	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	124-127
2833363-7	1987	The Tetrahymena mitochondrial code is analogous with the mammalian mitochondrial code; but differs from the Tetrahymena nuclear genetic code; TGA is exclusively translated as tryptophan; ATA is used as an initiation codon probably for methionine, and TAA as a stop codon; the arginine codons (CGN) are not used.	Arginine	276-284	T-box transcription factor 1	Homo sapiens	142-145
3315613-7	1987	All of these agents have the same biochemical mechanism of action, cleaving an arginine-valine bond in the plasminogen molecule to form plasmin, but they differ with regard to other important properties.	Arginine	79-87	plasminogen	Homo sapiens	107-114
3521732-9	1986	Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond.	Arginine	101-104	kallikrein B1	Homo sapiens	0-20
3521594-1	1986	Incubation of pig desoctapeptide-(B23-30)-insulin with trypsin in solvent systems consisting of dimethyl sulphoxide, butane-1,4-diol and Tris buffer resulted in the formation of an extra peptide bond between Arg-B22 and Gly-A1 in the DOPI molecule.	Arginine	208-211	insulin	Sus scrofa	42-49
3025221-8	1986	The tetrapeptide sequence Arg-Glu-Asp-Val (REDV), which is somewhat related to RGDS, was present in this peptide in a highly hydrophilic region of the type III connecting segment.	Arginine	26-29	ral guanine nucleotide dissociation stimulator	Homo sapiens	79-83
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Arginine	94-104	plasminogen	Homo sapiens	142-149
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Arginine	94-104	plasminogen	Homo sapiens	283-290
2933077-2	1985	Values of kinetic parameters for the hydrolysis of esters and p-nitroanilides of L-lysine and L-arginine catalyzed by the Lys77 form of human plasmin (EC 3.4.21.7) have been determined between pH 5.5 and 8 (I = 0.1 M) at 21 +/- 0.5 degrees C. Over the whole pH range explored, Lys77-plasmin catalysis conforms to simple Michaelis-Menten kinetics, and steady-state and pre-steady-state data may be consistently fitted to the minimum three-step mechanism: E + S in equilibrium (k+1/k-1)E X S----(k+2)E X P + P1----(k+3)E + P2 In spite of the higher specificity of lysyl derivatives for Lys77-plasmin rather than the arginyl ones, kinetic parameters also depend on the nature of the N-alpha substituent and/or of the alcoholic or p-nitroanilidic moiety of the substrate.	Arginine	94-104	plasminogen	Homo sapiens	283-290
3539734-1	1986	The insulin-secretional effect of arginine administrated to rabbits either intravenously or via alimentary tract was measured.	Arginine	34-42	insulin	Oryctolagus cuniculus	4-11
3161731-10	1985	The amino acid compositions of GP Ib beta and GP IX were similar but showed marked differences in the levels of glutamic acid, alanine, histidine and arginine.	Arginine	150-158	glycoprotein IX platelet	Homo sapiens	46-51
3693978-4	1986	In tests of endocrine function, the perfused pancreas responded by increasing insulin secretion within 1 min of elevating perfusate glucose concentration, and also secreted insulin promptly in response to 10 mM arginine.	Arginine	211-219	insulin	Mesocricetus auratus	173-180
4062877-0	1985	Essentiality of the active-site arginine residue for the normal catalytic activity of Cu,Zn superoxide dismutase.	Arginine	32-40	superoxide dismutase [Cu-Zn]	Bos taurus	86-112
3082877-3	1986	The C-terminal, cytoplasmic peptide domain of the IL-2 receptor, Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile, was synthesized and used as a substrate for protein kinase C. The Km for phosphorylation of the peptide by protein kinase C was 23 microM.	Arginine	69-72	interleukin 2 receptor subunit beta	Homo sapiens	50-63
2932824-4	1985	Benzamidine-binding sites of domain K5 and of plasmin light chain are simultaneously arginine-binding ones.	Arginine	85-93	plasminogen	Homo sapiens	46-53
3855550-6	1985	Limited tryptic digestion cleaves apohemopexin after arginine-216 into two half-molecules, whereas heme-saturated hemopexin is cleaved after lysine-101.	Arginine	53-61	hemopexin	Homo sapiens	37-46
3082877-3	1986	The C-terminal, cytoplasmic peptide domain of the IL-2 receptor, Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile, was synthesized and used as a substrate for protein kinase C. The Km for phosphorylation of the peptide by protein kinase C was 23 microM.	Arginine	73-76	interleukin 2 receptor subunit beta	Homo sapiens	50-63
6743677-6	1984	These results suggest that arginine-49 of apolipoprotein C-II is situated at or near an amino acid sequence domain involved in the activation of lipoprotein lipase.	Arginine	27-35	apolipoprotein C2	Bos taurus	42-61
6743677-6	1984	These results suggest that arginine-49 of apolipoprotein C-II is situated at or near an amino acid sequence domain involved in the activation of lipoprotein lipase.	Arginine	27-35	lipoprotein lipase	Bos taurus	145-163
3082877-3	1986	The C-terminal, cytoplasmic peptide domain of the IL-2 receptor, Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile, was synthesized and used as a substrate for protein kinase C. The Km for phosphorylation of the peptide by protein kinase C was 23 microM.	Arginine	73-76	interleukin 2 receptor subunit beta	Homo sapiens	50-63
3082877-3	1986	The C-terminal, cytoplasmic peptide domain of the IL-2 receptor, Gln-Arg-Arg-Gln-Arg-Lys-Ser-Arg-Arg-Thr-Ile, was synthesized and used as a substrate for protein kinase C. The Km for phosphorylation of the peptide by protein kinase C was 23 microM.	Arginine	73-76	interleukin 2 receptor subunit beta	Homo sapiens	50-63
2859285-0	1985	Identification of an essential arginine residue in the beta subunit of the chloroplast ATPase.	Arginine	31-39	AT695_RS06370	Staphylococcus aureus	87-93
2859285-1	1985	The ATPase activity of soluble chloroplast coupling factor (CF1) was irreversibly inactivated by phenylglyoxal, an arginine reagent.	Arginine	115-123	AT695_RS06370	Staphylococcus aureus	4-10
3009364-3	1986	Homology searches in protein data banks revealed the presence of the peptide SDGR in the alpha 2 domain of MHC class I antigens, and a variant of RGDS, Arg-Phe-Asp-Ser (RFDS), was found highly conserved in MHC class I (alpha 1 domain) and class II antigens (beta 1 domain).	Arginine	152-155	ral guanine nucleotide dissociation stimulator	Homo sapiens	146-150
2859285-11	1985	79, 6260-6264) indicated that the arginine marked with the asterisk, the predominant residue modified by phenylglyoxal when the ATPase activity of CF1 is inactivated by the reagent, is Arg 312.	Arginine	34-42	AT695_RS06370	Staphylococcus aureus	128-134
2859285-11	1985	79, 6260-6264) indicated that the arginine marked with the asterisk, the predominant residue modified by phenylglyoxal when the ATPase activity of CF1 is inactivated by the reagent, is Arg 312.	Arginine	185-188	AT695_RS06370	Staphylococcus aureus	128-134
3970979-2	1985	The greatest percentages of inhibition of TPA-induced epidermal ornithine decarboxylase activity were as follows: cysteine, 98%; tryptophan, 74%; methionine, 64%; phenylalanine, 51%; glycine, 44%; asparagine, 43%; glutamic acid, 42%; leucine, 40%; and arginine, 39%.	Arginine	252-260	ornithine decarboxylase 1	Homo sapiens	64-87
6383810-2	1984	Insulin was detected in the foetal plasma from as early as 150 days of gestation (term = 340 days) and during the last third of gestation the foetal beta cells responded to exogenous administration of glucose and arginine and to endogenous variations in the glucose level.	Arginine	213-221	INS	Equus caballus	0-7
6197164-1	1984	The plasminogen activators of surgically excised prostate cancers (43 specimens) and benign prostatic hyperplasias (33 specimens) were extracted with an acetate:arginine:detergent buffer, and the activities were quantitated with azocaseinolytic tests.	Arginine	161-169	plasminogen	Homo sapiens	4-15
6547932-0	1984	The characterization of hemoglobin Manitoba or alpha (2)102(G9)Ser----Arg beta 2 and hemoglobin Contaldo or alpha (2)103(G10)His----Arg beta 2 by high performance liquid chromatography.	Arginine	70-73	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-113
3907706-6	1985	The results show that the 1-P-histidinyl residue in HPr and HPr-1 has significantly different properties from free 1-P-histidine and that these differences are attributable to the active-site residues Glu-66 and Arg-17 and the pK of the imidazole group of the 1-P-histidinyl residue in P-HPr.	Arginine	212-215	haptoglobin-related protein	Homo sapiens	52-55
6130090-4	1983	The extent of maximum stimulation of the EF-Tu GTPase in the presence of ribosomes varies moderately depending on the aa-tRNA species; a clear dependence on the nature of the aminoacyl side chain is observed in the effects of their respective C-C-A-aa fragments tested (C-C-A-Arg, C-C-A-Val, C-C-A-Phe, C-C-A-Met, C-C-A-Lys).	Arginine	276-279	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	41-46
6090951-6	1984	These DNA sequences code for a protein of 92 amino acids in which the LHRH decapeptide is preceded by a signal peptide of 23 amino acids and followed by a Gly-Lys-Arg sequence, as expected for enzymatic cleavage of the decapeptide from its precursor and amidation of the carboxy-terminal of LHRH.	Arginine	163-166	gonadotropin releasing hormone 1	Homo sapiens	70-74
3907706-6	1985	The results show that the 1-P-histidinyl residue in HPr and HPr-1 has significantly different properties from free 1-P-histidine and that these differences are attributable to the active-site residues Glu-66 and Arg-17 and the pK of the imidazole group of the 1-P-histidinyl residue in P-HPr.	Arginine	212-215	THO complex 1	Homo sapiens	60-65
16453478-9	1983	This result implicates mutation of residue 5332 in the temperature sensitivity of viral assembly (by altering the structure of the RNA close to the assembly origin) and/or local lesion spreading (via a radical Arg to Gly substitution in p30 or its derivatives).	Arginine	210-213	centromere protein V	Homo sapiens	237-240
3907706-6	1985	The results show that the 1-P-histidinyl residue in HPr and HPr-1 has significantly different properties from free 1-P-histidine and that these differences are attributable to the active-site residues Glu-66 and Arg-17 and the pK of the imidazole group of the 1-P-histidinyl residue in P-HPr.	Arginine	212-215	haptoglobin-related protein	Homo sapiens	60-63
2932113-3	1985	Phenylglyoxal reacted with arginine residues of gizzard myosin in a mol ratio of two to one, phenylglyoxal to arginine as determined spectrophotometrically.	Arginine	27-35	myosin, heavy chain 15	Gallus gallus	56-62
6874376-0	1983	A case of hemoglobin Iwata [alpha 87(F8)His leads to Arg] in China.	Arginine	53-56	coagulation factor VIII	Homo sapiens	10-39
6743677-1	1984	Role of arginine in the activation of lipoprotein lipase.	Arginine	8-16	lipoprotein lipase	Bos taurus	38-56
6743677-2	1984	Apolipoprotein C-II, the activator protein of lipoprotein lipase, contains 78 amino acids with a single residue of arginine at position 49.	Arginine	115-123	apolipoprotein C2	Bos taurus	0-19
6743677-2	1984	Apolipoprotein C-II, the activator protein of lipoprotein lipase, contains 78 amino acids with a single residue of arginine at position 49.	Arginine	115-123	lipoprotein lipase	Bos taurus	46-64
6743677-3	1984	Chemical modification of apolipoprotein C-II with 1,2-cyclohexanedione or 2,3-butanedione results in a loss of both the arginine residue and the ability of the protein to enhance the activity of bovine milk lipoprotein lipase toward a trioleoylglycerol substrate; removal of the modifying group restores arginine and more than 70% of the activating property of the apolipoprotein.	Arginine	120-128	apolipoprotein C2	Bos taurus	25-44
6743677-3	1984	Chemical modification of apolipoprotein C-II with 1,2-cyclohexanedione or 2,3-butanedione results in a loss of both the arginine residue and the ability of the protein to enhance the activity of bovine milk lipoprotein lipase toward a trioleoylglycerol substrate; removal of the modifying group restores arginine and more than 70% of the activating property of the apolipoprotein.	Arginine	304-312	apolipoprotein C2	Bos taurus	25-44
6743677-4	1984	Arginine modification of apolipoprotein C-II does not effect its lipid-binding properties as assessed by its association to sonicated vesicles of dimyristoylphosphatidylcholine.	Arginine	0-8	apolipoprotein C2	Bos taurus	25-44
7174657-7	1982	This peptide in the rabbit enzyme, -Arg-Ile-Gln-Glu-Glu-Ala-Arg-Cys147-Leu-Val-Glu-Glu-Leu-Arg-, and the corresponding peptides containing Cys152 in P-450b and Cys134 in P-450cam may serve an essential function such as providing the axial thiolate ligand to the heme iron atom.	Arginine	36-39	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	149-155
7174657-7	1982	This peptide in the rabbit enzyme, -Arg-Ile-Gln-Glu-Glu-Ala-Arg-Cys147-Leu-Val-Glu-Glu-Leu-Arg-, and the corresponding peptides containing Cys152 in P-450b and Cys134 in P-450cam may serve an essential function such as providing the axial thiolate ligand to the heme iron atom.	Arginine	60-63	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	149-155
7174657-7	1982	This peptide in the rabbit enzyme, -Arg-Ile-Gln-Glu-Glu-Ala-Arg-Cys147-Leu-Val-Glu-Glu-Leu-Arg-, and the corresponding peptides containing Cys152 in P-450b and Cys134 in P-450cam may serve an essential function such as providing the axial thiolate ligand to the heme iron atom.	Arginine	60-63	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	149-155
2932113-3	1985	Phenylglyoxal reacted with arginine residues of gizzard myosin in a mol ratio of two to one, phenylglyoxal to arginine as determined spectrophotometrically.	Arginine	110-118	myosin, heavy chain 15	Gallus gallus	56-62
2932113-11	1985	Arginine residues of gizzard myosin are necessary for the maintenance of the ATPase activity of this contractile protein.	Arginine	0-8	myosin, heavy chain 15	Gallus gallus	29-35
6958342-3	1982	3 VIP was shown to be poor in increasing microvascular permeability but very potent in enhancing local oedema induced by two substances which increase permeability, bradykinin and C5a des Arg.	Arginine	188-191	VIP peptides	Oryctolagus cuniculus	2-5
6370138-7	1984	This cationic region, probably due to lysine and/or arginine residues, may serve in vivo to facilitate the interaction between hydrogenase and ferredoxin, the polyanionic, physiological electron mediator.	Arginine	52-60	uncharacterized protein	Chlamydomonas reinhardtii	143-153
4066154-6	1985	The effects produced by charged quenchers reveal that the ligand path from the surface of the molecule to the ion atom of the heme involves a positively charged residue which may reasonably be identified as Arg-45 (sperm whale myoglobin) or Lys-41 (tuna myoglobin) on the basis of recent X-ray crystallographic information.	Arginine	207-210	myoglobin	Physeter catodon	227-236
4066154-6	1985	The effects produced by charged quenchers reveal that the ligand path from the surface of the molecule to the ion atom of the heme involves a positively charged residue which may reasonably be identified as Arg-45 (sperm whale myoglobin) or Lys-41 (tuna myoglobin) on the basis of recent X-ray crystallographic information.	Arginine	207-210	myoglobin	Physeter catodon	254-263
6530022-1	1984	Like arginyl-tRNA synthetases from other organisms, human placental arginyl-tRNA synthetase catalyzes the arginine-dependent ATP-PPi exchange reaction only in the presence of tRNA.	Arginine	106-114	arginyl-tRNA synthetase 1	Homo sapiens	5-28
3970979-5	1985	Arginine, phenylalanine and methionine inhibited the induction of ornithine decarboxylase activity by the tumor promoter to degrees comparable to those elicited by their analogs canavanine and homoarginine, beta-2-thienyl-DL-alanine, and ethionine, respectively.	Arginine	0-8	ornithine decarboxylase 1	Homo sapiens	66-89
3970979-5	1985	Arginine, phenylalanine and methionine inhibited the induction of ornithine decarboxylase activity by the tumor promoter to degrees comparable to those elicited by their analogs canavanine and homoarginine, beta-2-thienyl-DL-alanine, and ethionine, respectively.	Arginine	0-8	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	207-213
6363240-2	1983	We have investigated, therefore, the effects of a protein-rich meal or meat extract ingestion on plasma PP secretion and examined also the effects of intravenous arginine administration on PP levels in normal subjects and in patients with noninsulin-dependent diabetes mellitus (NIDDM).	Arginine	162-170	pancreatic polypeptide	Homo sapiens	189-191
2986682-2	1985	Modification of pig muscle carbonic anhydrase III with the arginine reagent phenylglyoxal yielded two clearly distinctive results.	Arginine	59-67	carbonic anhydrase 3	Sus scrofa	27-49
6363240-6	1983	In normal subjects, plasma PP rose abruptly after a bolus arginine injection (4 g for 2 min) and then remained at significantly high levels even 30 min after the injection.	Arginine	58-66	pancreatic polypeptide	Homo sapiens	27-29
6363240-7	1983	In NIDDM, however, plasma PP levels tended to increase, but not significantly, after the bolus arginine injection.	Arginine	95-103	pancreatic polypeptide	Homo sapiens	26-28
6363240-8	1983	Since in NIDDM the protein-rich meal and meat extract ingestion produced an exaggerated rise in plasma PP while the PP responses to the intravenous arginine administration were rather impaired compared with normal subjects, we suggest that the entero-PP axis is overactive in NIDDM.	Arginine	148-156	pancreatic polypeptide	Homo sapiens	116-118
6363240-8	1983	Since in NIDDM the protein-rich meal and meat extract ingestion produced an exaggerated rise in plasma PP while the PP responses to the intravenous arginine administration were rather impaired compared with normal subjects, we suggest that the entero-PP axis is overactive in NIDDM.	Arginine	148-156	pancreatic polypeptide	Homo sapiens	116-118
3893464-6	1985	The structural analysis showed that beta 2-Bern differs at only one position from beta 1: Arg-47 in beta 1 is substituted for His-47 in beta 2-Bern.	Arginine	90-93	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	36-42
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Arginine	195-198	Mf(Alpha)2p	Saccharomyces cerevisiae S288C	0-10
6306574-6	1983	MF alpha 2 gene contains coding sequences for two copies of the alpha-factor that differ from each other and from alpha-factor encoded by MF alpha 1 gene by a Gln leads to Asn and a Lys leads to Arg substitution.	Arginine	195-198	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	138-148
3155608-3	1985	The rise in C3b receptor number was ascribed to up-regulation by C3a and C5a des Arg from complement activation and also, in the cases where sepsis occurred, to the presence of bacterial chemotactic peptides.	Arginine	81-84	endogenous retrovirus group K member 3	Homo sapiens	12-15
6408432-0	1983	[Inhibition of arginine-stimulated pancreatic glucagon secretion with biosynthetic human insulin and swine insulin in healthy subjects and diabetics].	Arginine	15-23	insulin	Sus scrofa	107-114
3853779-1	1985	Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential.	Arginine	39-42	seryl-tRNA synthetase 1	Bos taurus	89-110
7158628-1	1982	Hemoglobin Queens: alpha 34 (B15) Leu-Arg was found in association with Hb E in a Vietnamese boy.	Arginine	38-41	hemoglobin subunit epsilon 1	Homo sapiens	72-76
6762537-5	1982	Analogs with non-aromatic or hydrophilic amino acids (X: Gly, Leu, Arg, His, Glu) in position 1 generally have much lower activities in this series of LH-RH antagonists.	Arginine	67-70	gonadotropin releasing hormone 1	Homo sapiens	151-156
6752634-6	1982	L-leucine, L-arginine and theophylline also potentiated glucose-induced insulin release in the presence of L-asparaginase.	Arginine	11-21	insulin	Oryctolagus cuniculus	72-79
6180133-0	1982	In vivo methylation of an arginine in chicken myelin basic protein.	Arginine	26-34	myelin basic protein	Gallus gallus	46-66
7030827-8	1981	A significant inhibition of insulin release in response to the loading of glucose, glucagon, or arginine was observed in the TPTF rabbits (P less than 0.02).	Arginine	96-104	insulin	Oryctolagus cuniculus	28-35
6787182-7	1981	The arginine-induced decrease in brain lysine concentration is consistent with the hypothesis that induction of amino acid imbalances may involve competition for transport into the brain of an indispensable, limiting amino acid; growth depressions caused by BCAA or IAA appear to involve other factors as well.	Arginine	4-12	AT-rich interaction domain 4B	Rattus norvegicus	258-262
7216471-3	1981	MCP-2 was approximately half as abundant as MCP-1 and contained relatively less arginine (14.9 mol%) and half cystine (9.8 mol%).	Arginine	80-88	corticostatin-4	Oryctolagus cuniculus	0-5
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	118-126	plasminogen	Homo sapiens	128-135
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	160-168	plasminogen	Homo sapiens	128-135
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	160-168	plasminogen	Homo sapiens	128-135
6773954-9	1980	A rapid chromatographic procedure for the separation of methylated lysines and arginines was developed and used to demonstrate that epsilon-trimethyllysine is the radioactive amino acid formed when calmodulin is methylated in vitro.	Arginine	79-88	calmodulin 1	Rattus norvegicus	198-208
6104406-2	1980	After stimulation of insulin release with glucose and arginine, respectively, a prompt decrease in PP levels was found in pancreatic venous blood.	Arginine	54-62	insulin	Sus scrofa	21-28
6995104-3	1980	To investigate the role of pancreatic glucagon we have studied the effect of arginine infusion on monocyte insulin receptor in five normal subjects.	Arginine	77-85	insulin receptor	Homo sapiens	107-123
6444782-6	1980	In contrast, the chicken somatostatin secretion was markedly stimulated by glucose and by arginine.	Arginine	90-98	somatostatin 1	Gallus gallus	25-37
109272-3	1979	Arginine caused release of TRH from the preparation.	Arginine	0-8	thyrotropin releasing hormone	Rattus norvegicus	27-30
109272-9	1979	TRH enhanced arginine-induced glucagon release; mean summated glucagon was 8228 +/- 1138 (SE) pg/ml compared to controls (4530 +/- 447 pg/ml; P less than 0.01).	Arginine	13-21	thyrotropin releasing hormone	Rattus norvegicus	0-3
640983-0	1978	Plasma levels of growth hormone and insulin in protein malnourished vs normal growing pigs in response to arginine or glucose infusion.	Arginine	106-114	insulin	Sus scrofa	36-43
590940-5	1977	This compound was digested by carboxypeptidase B to remove the arginine residue B22 at the end of the B chain.	Arginine	63-71	carboxypeptidase B1 (tissue)	Mus musculus	30-48
271957-3	1977	ApoC-II contains a single arginine residue, permitting tryptic cleavage into two peptides after succinylation of the native protein.	Arginine	26-34	apolipoprotein C2	Homo sapiens	0-7
948374-4	1976	In travenous arginine increased hCS levels, new evidence of the great similarity of structure and function between growth hormone and hCS.	Arginine	13-21	holocarboxylase synthetase	Homo sapiens	32-35
948374-4	1976	In travenous arginine increased hCS levels, new evidence of the great similarity of structure and function between growth hormone and hCS.	Arginine	13-21	holocarboxylase synthetase	Homo sapiens	134-137
820711-0	1976	Suppression by thyrotropin-releasing hormone (TRH) of growth hormone release induced by arginine and insulin-induced hypoglycemia in man.	Arginine	88-96	thyrotropin releasing hormone	Homo sapiens	15-44
820711-0	1976	Suppression by thyrotropin-releasing hormone (TRH) of growth hormone release induced by arginine and insulin-induced hypoglycemia in man.	Arginine	88-96	thyrotropin releasing hormone	Homo sapiens	46-49
820711-2	1976	When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively.	Arginine	121-129	thyrotropin releasing hormone	Homo sapiens	15-44
820711-2	1976	When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively.	Arginine	121-129	thyrotropin releasing hormone	Homo sapiens	46-49
820711-2	1976	When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively.	Arginine	173-181	thyrotropin releasing hormone	Homo sapiens	15-44
820711-2	1976	When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively.	Arginine	173-181	thyrotropin releasing hormone	Homo sapiens	46-49
7095086-0	1982	Essential arginine residues occur in or near the catalytic site of L-amino acid oxidase.	Arginine	10-18	interleukin 4 induced 1	Homo sapiens	67-87
7095086-3	1982	These results are consistent with the modification by butanedione of one or more arginine residues located in or near the catalytic site of L-amino acid oxidase.	Arginine	81-89	interleukin 4 induced 1	Homo sapiens	140-160
6277942-7	1982	A peptide with the sequence, Leu-Ser-Tyr-Arg-Arg-Tyr-Ser-Leu was phosphorylated initially by phosphorylase kinase and cAMP-dependent protein kinase at Ser-2 and Ser-7, respectively.	Arginine	41-44	jagged canonical Notch ligand 2	Homo sapiens	151-156
6277942-7	1982	A peptide with the sequence, Leu-Ser-Tyr-Arg-Arg-Tyr-Ser-Leu was phosphorylated initially by phosphorylase kinase and cAMP-dependent protein kinase at Ser-2 and Ser-7, respectively.	Arginine	45-48	jagged canonical Notch ligand 2	Homo sapiens	151-156
6281785-1	1982	alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores.	Arginine	128-131	pro-opiomelanocortin-alpha	Mus musculus	0-36
7055581-0	1982	Essential arginine residues in the pyridine nucleotide binding sites of glutathione reductase.	Arginine	10-18	glutathione-disulfide reductase	Homo sapiens	72-93
7055581-1	1982	Glutathione reductase (NAD(P)H: oxidized-glutathione oxidoreductase, EC 1.6.4.2) from human erythrocytes as well as from other sources was inactivated irreversibly by the arginine modifying reagents 2,3-butanedione, 1,2-cyclohexanedione and phenylglyoxal.	Arginine	171-179	glutathione-disulfide reductase	Homo sapiens	0-21
7256256-4	1981	The N-terminal amino acids of SCP-1 and SCP-2 are Arginine and Tryptophan respectively.	Arginine	50-58	sterol carrier protein 2	Rattus norvegicus	40-45
7030721-4	1981	Insulin secretion was significantly increased in IAP treated pancreatic islets by the glucose and the arginine stimuli.	Arginine	102-110	islet amyloid polypeptide	Homo sapiens	49-52
6166608-4	1981	During incubation, much more insulin was released from IAP-treated islets than control islets in response to glucose, arginine, glucagon, and sulfonylurea.	Arginine	118-126	Cd47 molecule	Rattus norvegicus	55-58
7009247-5	1980	Arginine induced insulin and glucagon secretion.	Arginine	0-8	insulin	Anas platyrhynchos	17-24
3853779-1	1985	Study by chemical modification of Ser, Arg, His residues and sulfhydryl groups on bovine seryl-tRNA synthetase showed that Ser residues appeared to be unnecessary for the recognition mechanism, but Arg and His residues were essential.	Arginine	198-201	seryl-tRNA synthetase 1	Bos taurus	89-110
3841688-6	1985	Three such peptides have been detected which are presumably liberated from caerulein precursors by cleavage at single arginine residues.	Arginine	118-126	XT-6 like precursor L homeolog	Xenopus laevis	75-84
3929498-5	1985	In 4 patients a stimulation test with GRH-TRH or Arg-GRH-TRH, respectively, was performed.	Arginine	49-52	gonadotropin releasing hormone 1	Homo sapiens	53-56
3931389-0	1985	[Arginine-GnRH-TRH test in patients with primary hypothalamic amenorrhea].	Arginine	1-9	thyrotropin releasing hormone	Homo sapiens	15-18
6378668-5	1984	Thus, Arg-47 in beta 1 is substituted by His in beta 2-Bern.	Arginine	6-9	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	48-54
6092230-2	1984	The hybrid plasmid pCR501 constructed for this purpose contains cDNA coding for PC (from the 5th Arg to the C-terminal Ile) fused to the N-terminal fragment of the trpE gene preceded by the trp promoter and attenuator region.	Arginine	97-100	chymosin	Bos taurus	80-82
6086333-8	1984	Porin-induced hemolysis was inhibited with anti-porin serum, as well as by a treatment with phenylglyoxal, which reacts with the arginine residues of proteins.	Arginine	129-137	voltage dependent anion channel 1	Homo sapiens	0-5
6374651-3	1984	Here, the beta 2 form has a histidine residue, while, in common with other characterized mammalian liver alcohol dehydrogenases, the beta 1 form has an arginine residue.	Arginine	152-160	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	10-16
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Arginine	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	205-211
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Arginine	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Arginine	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6374651-5	1984	The histidine/arginine-47 mutational replacement corresponds to a position that binds the pyrophosphate group of the coenzyme NAD(H); this explains the functional differences between the beta 1 beta 1 and beta 2 beta 2 isozymes, including both a lower pH optimum and higher turnover number of beta 2 beta 2, which is likely to be the mutant form.	Arginine	14-22	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	212-218
6609366-6	1984	In vitro, the valine form of p21 had 2.4- and 2.7-fold greater autophosphorylating activity than the glycine and arginine forms of p21, respectively, using [gamma-32P]GTP as phosphate donor, but the three p21 species had similar Km values for GTP (0.20-0.27 microM).	Arginine	113-121	transcription elongation factor A like 1	Homo sapiens	29-32
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	47-55	gonadotropin releasing hormone 1	Homo sapiens	77-81
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	47-55	gonadotropin releasing hormone 1	Homo sapiens	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	296-304	gonadotropin releasing hormone 1	Homo sapiens	77-81
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	296-304	gonadotropin releasing hormone 1	Homo sapiens	115-119
6639687-13	1983	Lysine, arginine, L-canavanine and polymyxin B all affected NAG release from lysosomes in vitro.	Arginine	8-16	O-GlcNAcase	Rattus norvegicus	60-63
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Arginine	156-159	cathepsin D	Homo sapiens	30-41
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Arginine	168-171	cathepsin D	Homo sapiens	30-41
6315008-10	1983	On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr.	Arginine	168-171	cathepsin D	Homo sapiens	30-41
6626500-2	1983	The following peptide was synthesized by classical methods in solution: Ac-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg-Gly-Pro-Arg-Val-NHCH3 (F-8).	Arginine	111-114	coagulation factor VIII	Homo sapiens	138-141
393-2	1975	Hemoglobin Deer Lodge is an abnormal human hemoglobin with arginine substituted for histidine at the beta 2 position.	Arginine	59-67	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	101-107
54037-1	1975	AFP and albumin are produced by arginine-synthesizing fetal rat hepatocytes in vitro.	Arginine	32-40	alpha-fetoprotein	Rattus norvegicus	0-3
6626500-3	1983	The Michaelis-Menten parameters for the hydrolysis of the Arg-Gly bond in F-8 by thrombin were determined to be Kcat = 31 X 10(-11) M [(NIH unit/L) s]-1 and KM = 310 X 10(-6) M. Comparison of these values with those determined previously for native fibrinogen and for a series of similar synthetic peptides, together with information about the amino acid sequences of this portion of the A alpha chain of abnormal fibrinogens, suggests an important role for Asp at position P10.	Arginine	58-61	coagulation factor VIII	Homo sapiens	74-77
6186522-0	1982	Hb F Kingston (G gamma 55 [D6] Met leads to Arg).	Arginine	44-47	atypical chemokine receptor 2	Homo sapiens	15-29
4594711-2	1974	In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited.	Arginine	33-41	insulin	Felis catus	66-73
7462179-6	1980	The findings are compared with those for Hb Suresnes (alpha 2 141 (HC3) Arg leads His beta2) and Hb-CPB, a normal hemoglobin in which the C-terminal alpha 141 Arg has been cleaved by carboxypeptidase B.	Arginine	72-75	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	86-91
7041967-1	1982	The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates.	Arginine	182-185	gonadotropin releasing hormone 1	Homo sapiens	98-135
6771491-2	1980	The majority of these mutations, belonging to classes 1, 2 and 4 of Harwood and Baumberg (1977) and affecting only expression of arginine catabolic enzymes, map at a locus designated ahr A cotransducible with cysA, purA and sacA.	Arginine	129-137	aryl hydrocarbon receptor	Homo sapiens	183-186
6771491-5	1980	A single ahr mutation (class 3), also affecting only arginine catabolism, maps between ctrA and sacA at a locus designated ahrB.	Arginine	53-61	aryl hydrocarbon receptor	Homo sapiens	9-12
433615-0	1979	The effect of metformin on the arginine induced insulin- and glucagon release in pigs.	Arginine	31-39	insulin	Sus scrofa	48-55
33410970-2	2021	Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation.	Arginine	94-104	arginase 1	Homo sapiens	12-16
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Arginine	246-249	SLC2A4 regulator	Homo sapiens	47-50
420414-3	1979	For the first time our results show that the low arginine content in pathological sperm is not due to disorder of the precursor metabolism, but to the increased arginase activity and to the increased conversion of arginine to GAA.	Arginine	49-57	alpha glucosidase	Homo sapiens	226-229
7041967-1	1982	The substrate specificity of a peptidase from anterior pituitaries that is capable of hydrolyzing luteinizing hormone-releasing hormone (LH-RH; less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) at the Tyr5-Gly6 peptide bond has been investigated by using inhibitors and model substrates.	Arginine	182-185	gonadotropin releasing hormone 1	Homo sapiens	137-142
6896041-1	1982	In the goose, alanine and arginine, intravenously or orally administered, act in the same way on pancreatic hormones; they both stimulate insulin and glucagon secretions.	Arginine	26-34	insulin	Anas platyrhynchos	138-145
703761-4	1978	A fraction of the original Chl- mutants presented a requirement for arginine (ArgB-).	Arginine	68-76	chordin like 1	Homo sapiens	27-30
33983734-3	2021	The structure of the C-clamp domain from human GEF family protein HDBP1 (C-clampHDBP1) in complex with DNA was determined using NMR spectroscopy, which adopts a unique zinc finger fold and selectively binds RCCGG (R = A/G) DNA sequences with an "Arg   Trp-Lys-Lys" DNA recognition motif inserted in the major groove.	Arginine	246-249	SLC2A4 regulator	Homo sapiens	66-71
6896041-9	1982	Furthermore, insulin seems to be able to inhibit the alpha cell response to arginine infusion, as in mammals, whereas this is not the case in ducks.	Arginine	76-84	insulin	Anas platyrhynchos	13-20
33645250-5	2021	When administered from the vascular side, L-arginine and the aromatic amino acids stimulated GLP-1 secretion equally (2.6-2.9 fold increases).	Arginine	42-52	glucagon	Mus musculus	93-98
65186-6	1977	The N-terminal amino acids were found to be Lys, Arg and Leu respectively for the three forms of post gamma-globulin.	Arginine	49-52	cystatin C	Homo sapiens	97-116
7028121-8	1981	When the hexapeptide Leu-Trp-Met-Arg-Phe-Ala was used as a substrate for proteinase B, the enzyme preferentially attacked at Arg-Phe and more slowly at Trp-Met.	Arginine	33-36	proteinase B	Saccharomyces cerevisiae S288C	73-85
1236817-14	1975	Effect of arginine on the concentrations of serum hGH, hPRL and hCS during pregnancy.	Arginine	10-18	holocarboxylase synthetase	Homo sapiens	64-67
33927350-0	2021	Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS.	Arginine	0-8	mitochondrial ribosomal protein S23	Homo sapiens	35-41
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	mitochondrial ribosomal protein S23	Homo sapiens	76-111
7028121-8	1981	When the hexapeptide Leu-Trp-Met-Arg-Phe-Ala was used as a substrate for proteinase B, the enzyme preferentially attacked at Arg-Phe and more slowly at Trp-Met.	Arginine	125-128	proteinase B	Saccharomyces cerevisiae S288C	73-85
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	mitochondrial ribosomal protein S23	Homo sapiens	113-119
7316981-0	1981	Evidence for an essential arginine residue at the active site of ATP citrate lyase from rat liver.	Arginine	26-34	ATP citrate lyase	Rattus norvegicus	65-82
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	apolipoprotein L1	Homo sapiens	107-112
1122293-8	1975	Of the basic amino acids platelet factor 4 (molecular weight 27 100) contained 5.97% arginine, 3.18% histidine, and 12.31% lysine compared to protamine sulphate with 64.2% arginine, 0.6% lysine and no histidine.	Arginine	85-93	platelet factor 4	Homo sapiens	25-42
1112778-0	1975	Identification of functional arginine residues in ribonuclease A and lysozyme.	Arginine	29-37	lysozyme C, tracheal isozyme	Bos taurus	69-77
1112778-11	1975	With egg white lysozyme, all 11 arginine residues react with cyclohexanedione, resulting in partial inactivation of the enzyme.	Arginine	32-40	lysozyme C, tracheal isozyme	Bos taurus	15-23
7248314-1	1981	Modification of 12 arginine residues per molecule of formate dehydrogenase (formate : NAD+ oxidoreductase, EC 1.2.1.2.)	Arginine	19-27	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	91-105
4477005-3	1974	The kinetics of hydrolysis of these and esters of the alpha-N-toluene-p-sulphonyl and alpha-N-benzoyl derivatives of l-arginine, l-lysine, S-(2-aminoethyl)-l-cysteine and esters of gamma-guanidino-l-alpha-toluene-p-sulphonamidobutyric acid and alpha-N-toluene-p-sulphonyl-l-homoarginine by alpha- and beta-trypsin were compared.	Arginine	117-127	serine protease 1	Bos taurus	290-313
33967699-4	2021	Evidence has now accumulated showing that the formation and function of these membraneless organelles is impaired by both the toxic arginine rich dipeptide repeat proteins (DPRs), translated from the C9orf72 repeat RNA transcript, and the repeat RNA itself.	Arginine	132-140	C9orf72-SMCR8 complex subunit	Homo sapiens	200-207
7254778-10	1981	This observation suggests that the bulk of ingested arginine is somehow metabolized despite the severe reduction in ornithine-delta-aminotransferase activity.	Arginine	52-60	ornithine aminotransferase	Homo sapiens	116-148
33948161-1	2021	The L-arginine precursor, L-citrulline, re-couples endothelial nitric oxide synthase, increases nitric oxide production, and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.	Arginine	4-14	nitric oxide synthase 3	Sus scrofa	51-84
5144756-2	1971	Both growth hormone and insulin, when present in the medium separately, stimulated the incorporation into protein of the amino acids, leucine, arginine, valine, lysine and histidine.	Arginine	143-151	insulin	Oryctolagus cuniculus	24-31
6449829-3	1980	This substance, designated "plasmin", was separated from plasmin and kallikrein in a three-step procedure using columns of lysine-Sepharose, DEAE-Sephadex A-50, and arginine-Sepharose.	Arginine	165-173	plasminogen	Homo sapiens	28-35
5340761-0	1967	The arginine provocative test: an aid in the diagnosis of hyposomatotropism.	Arginine	4-12	activation induced cytidine deaminase	Homo sapiens	34-37
33837088-0	2021	C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.	Arginine	16-24	C9orf72-SMCR8 complex subunit	Homo sapiens	0-7
33837088-8	2021	Collectively, our study implicates inhibitory interactions of arginine-rich DPRs with axonal transport machinery in C9orf72-associated ALS/FTD and thereby points to potential therapeutic strategies.	Arginine	62-70	C9orf72-SMCR8 complex subunit	Homo sapiens	116-123
33887226-8	2021	A newly identified RBD motif of RILPL2, termed the X-cap, has been shown to recognize the phosphate via direct interactions between an arginine residue (R132) and pT72 of Rab8a.	Arginine	135-143	Rab interacting lysosomal protein like 2	Homo sapiens	32-38
7002081-0	1980	Effect of ethanol on basal and arginine-stimulated plasma levels of glucose, insulin and glucagon in fasted unanesthetized rabbits.	Arginine	31-39	insulin	Oryctolagus cuniculus	77-84
33887226-9	2021	Here we show that a second "distal" arginine (R130) is also essential for phospho-Rab binding by RILPL2.	Arginine	36-44	Rab interacting lysosomal protein like 2	Homo sapiens	97-103
6446025-7	1980	Lysine (or arginine residues) or end amino acid NH2-group and cysteine residues HS-group, and some tryptophane residues are at ATPase centre of (Ca--Mg)-ATPase from sarcoplasmic reticulum.	Arginine	11-19	dynein axonemal heavy chain 8	Homo sapiens	127-133
34036108-6	2021	During Leishmania-macrophage interaction, IGF-I acts on the arginine metabolic pathway, resulting in polyamine production both in macrophages and Leishmania.	Arginine	60-68	insulin-like growth factor 1	Mus musculus	42-47
33660773-6	2021	During induced erythroid maturation of K562 cells, decreasing arginine dimethylation of HNRNPK is linked to a reduced interaction with RPS19 in vitro and in vivo.	Arginine	62-70	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	88-94
6446025-7	1980	Lysine (or arginine residues) or end amino acid NH2-group and cysteine residues HS-group, and some tryptophane residues are at ATPase centre of (Ca--Mg)-ATPase from sarcoplasmic reticulum.	Arginine	11-19	dynein axonemal heavy chain 8	Homo sapiens	153-159
33524560-1	2021	Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing the immunotherapeutic efficacy.	Arginine	51-61	arginase 1	Homo sapiens	0-10
6990147-0	1980	Interaction of a newly isolated intestinal polypeptide (PHI) with glucose and arginine to effect the secretion of insulin and glucagon.	Arginine	78-86	glucose-6-phosphate isomerase	Homo sapiens	56-59
33524560-1	2021	Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing the immunotherapeutic efficacy.	Arginine	51-61	arginase 1	Homo sapiens	12-16
33928785-2	2021	The loss of arginine at position 14 in PLN (R14del) is associated with dilated cardiomyopathy (DCM) with a high prevalence of ventricular arrhythmias.	Arginine	12-20	phospholamban	Homo sapiens	39-42
44451-0	1979	Essential arginine residues in human liver arylsulfatase A.	Arginine	10-18	arylsulfatase A	Homo sapiens	43-58
33852844-0	2021	Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.	Arginine	46-54	huntingtin	Homo sapiens	0-10
33852844-2	2021	To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington"s disease (HD), we study vesicle-associated HTT and find that it is dimethylated at a highly conserved arginine residue (R118) by the protein arginine methyltransferase 6 (PRMT6).	Arginine	207-215	huntingtin	Homo sapiens	148-151
33852844-6	2021	Arginine methylation thus regulates HTT-mediated vesicular transport along the axon, and increasing HTT methylation could be of therapeutic interest for HD.	Arginine	0-8	huntingtin	Homo sapiens	36-39
33742119-5	2021	Mechanistically, mass spectrometry analysis identified that PKP2 was methylated at the arginine site and interacted with protein arginine methyltransferase 1 (PRMT1).	Arginine	87-95	plakophilin 2	Homo sapiens	60-64
224122-4	1979	Dose-dependent inhibition was also noted with synthetic proteinase substrates, especially those of chymotrypsin-like specificity, phenylalanine and tryptophan methyl esters (ID50S approximately 1.5 X 10(-4)M), as compared to derivatives of basic amino acids, arginine and acetyl-lysine methyl esters, which caused negligible inhibition at 10(-3M.	Arginine	259-267	endogenous retrovirus group K member 18	Homo sapiens	56-66
33754845-1	2021	Arginase-1, an enzyme that catalyzes the reaction of L-arginine to L-ornithine, is implicated in the tumor immune response and represents an interesting therapeutic target in immuno-oncology.	Arginine	53-63	arginase 1	Homo sapiens	0-10
33437999-1	2021	BACKGROUND: Suckling piglets synthesize most of their creatine requirement, which consumes substantial amounts of arginine in order to synthesize guanidinoacetic acid (GAA) and methionine in order to transmethylate GAA to creatine.	Arginine	114-122	alpha glucosidase	Homo sapiens	168-171
33437999-1	2021	BACKGROUND: Suckling piglets synthesize most of their creatine requirement, which consumes substantial amounts of arginine in order to synthesize guanidinoacetic acid (GAA) and methionine in order to transmethylate GAA to creatine.	Arginine	114-122	alpha glucosidase	Homo sapiens	215-218
33500272-3	2021	Pegzilarginase, a human arginase 1 enzyme engineered to have superior stability and enzymatic activity relative to the native human arginase 1 enzyme, depletes systemic arginine by converting it to ornithine and urea.	Arginine	169-177	arginase 1	Homo sapiens	24-34
33500272-3	2021	Pegzilarginase, a human arginase 1 enzyme engineered to have superior stability and enzymatic activity relative to the native human arginase 1 enzyme, depletes systemic arginine by converting it to ornithine and urea.	Arginine	169-177	arginase 1	Homo sapiens	132-142
762166-4	1979	Enterokinase hydrolyzed lysine and arginine substrates and slowly reacted with the trypsin active site titrant 4-methylumbelliferyl-p-guanidinobenzoate.	Arginine	35-43	transmembrane serine protease 15	Bos taurus	0-12
33383246-3	2021	The batch adsorption experiments showed that the DTAC-PST exhibited better in the removal of MB, ARG and H2PO4- than that of other adsorbents.	Arginine	97-100	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	54-57
33383246-4	2021	The theoretical maximum adsorption capacity of DTAC-PST is 49.28 mg g-1 for NH4+, 34.74 mg g-1 for TP, 81.87 mg g-1 for MB and 545.81 mg g-1 for ARG.	Arginine	145-148	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	52-55
33383246-5	2021	The simultaneous adsorption results showed that the concentration (10 mg L-1 of NH4+, 3 mg L-1 of TP, 50 mg L-1 of MB and 50 mg L-1 of ARG) of all the four chemicals in simulated wastewater could be controlled to be below the discharge levels in China (GB, 18918-2002) by DTAC-PST at the pH of 3.0.	Arginine	135-138	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	277-280
33444456-2	2021	Immune compromised patients harbor hypomorphic LIG1 alleles encoding substitutions of conserved arginine residues, R771W and R641L, that compromise LIG1 activity through poorly defined mechanisms.	Arginine	96-104	DNA ligase 1	Homo sapiens	47-51
33444456-2	2021	Immune compromised patients harbor hypomorphic LIG1 alleles encoding substitutions of conserved arginine residues, R771W and R641L, that compromise LIG1 activity through poorly defined mechanisms.	Arginine	96-104	DNA ligase 1	Homo sapiens	148-152
35240-4	1979	It is shown that the two biologically essential arginine residues (Arg1 and Arg9) are important for the specific folded bradykinin conformation.	Arginine	48-56	arginase 1	Homo sapiens	67-71
33594058-2	2021	Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1).	Arginine	8-16	CREB regulated transcription coactivator 1	Mus musculus	27-33
33574035-5	2021	In the complexes with H3 and CENP-A nucleosomes, SET8 specifically binds the nucleosomal acidic patch via an arginine anchor, composed of the Arg188 and Arg192 residues.	Arginine	109-117	centromere protein A	Homo sapiens	29-35
33574035-5	2021	In the complexes with H3 and CENP-A nucleosomes, SET8 specifically binds the nucleosomal acidic patch via an arginine anchor, composed of the Arg188 and Arg192 residues.	Arginine	109-117	lysine methyltransferase 5A	Homo sapiens	49-53
33574035-6	2021	Mutational analyses revealed that the interaction between the SET8 arginine anchor and the nucleosomal acidic patch plays an essential role in the H4K20 monomethylation activity.	Arginine	67-75	lysine methyltransferase 5A	Homo sapiens	62-66
33833668-0	2021	Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD.	Arginine	32-40	C9orf72-SMCR8 complex subunit	Homo sapiens	56-63
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Arginine	160-163	angiotensin converting enzyme 2	Homo sapiens	109-113
499737-0	1979	Involvement of arginine residues in the catalytic activity of catechol-O-methyltransferase.	Arginine	15-23	catechol-O-methyltransferase	Homo sapiens	62-90
762194-2	1979	A multi-step selection procedure is described which selects from HR-II-E populations, cells with OCT activity which can grow in arginine-deficient, ornithine-supplemented media.	Arginine	128-136	ornithine transcarbamylase	Rattus norvegicus	97-100
33667543-0	2021	Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.	Arginine	0-8	SMAD family member 1	Homo sapiens	58-63
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 1	Homo sapiens	291-296
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 1	Homo sapiens	361-366
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 4	Homo sapiens	367-372
213127-3	1978	Also, the amino acid arginine would induce ornithine decarboxylase in this cell type following arginine starvation for 24 h. These observations are in contrast to the wide range of hormones, e.g. insulin, hydrocortisone, glucagon and growth hormone, than can induce ornithine decarboxylase in vivo in the adult rat liver but which are all without effect on fetal rat liver cells.	Arginine	21-29	gonadotropin releasing hormone receptor	Rattus norvegicus	234-248
33711670-5	2021	With a few exceptions, brain tumors show increased activities of one or all of the three arginine (Arg) to NO-converting nitric oxide synthase (NOS) isoforms (iNOS, eNOS, nNOS), but also elevated activities of polyamines-generating and modifying enzymes: arginase I/II, ornithine decarboxylase and spermidine/spermine N1-acetyltransferase.	Arginine	89-97	nitric oxide synthase 1	Homo sapiens	121-142
33711670-5	2021	With a few exceptions, brain tumors show increased activities of one or all of the three arginine (Arg) to NO-converting nitric oxide synthase (NOS) isoforms (iNOS, eNOS, nNOS), but also elevated activities of polyamines-generating and modifying enzymes: arginase I/II, ornithine decarboxylase and spermidine/spermine N1-acetyltransferase.	Arginine	89-97	ornithine decarboxylase 1	Homo sapiens	270-293
33711670-5	2021	With a few exceptions, brain tumors show increased activities of one or all of the three arginine (Arg) to NO-converting nitric oxide synthase (NOS) isoforms (iNOS, eNOS, nNOS), but also elevated activities of polyamines-generating and modifying enzymes: arginase I/II, ornithine decarboxylase and spermidine/spermine N1-acetyltransferase.	Arginine	99-102	nitric oxide synthase 1	Homo sapiens	121-142
33732412-2	2021	Through the replacement of arginine by the less basic canavanine, new inhibitors targeting furin in the trans-Golgi network were developed.	Arginine	27-35	furin, paired basic amino acid cleaving enzyme	Homo sapiens	91-96
33536412-2	2021	In this work, an arginine containing region in the second C2 domain of synaptotagmin 1 (C2B) is shown to control the expansion of the fusion pore and thereby the concentration of neurotransmitter released.	Arginine	17-25	synaptotagmin 1	Homo sapiens	71-86
684614-10	1978	These are thought to be associated with an arginine-induced growth hormone release.	Arginine	43-51	gonadotropin releasing hormone receptor	Rattus norvegicus	60-74
33475463-6	2021	MiR-125a targeted DRAM2 to ameliorate cardiomyocyte autophagy and oxidative injury following H/R treatment.	Arginine	2-3	DNA damage regulated autophagy modulator 2	Rattus norvegicus	18-23
33492002-4	2021	RECENT FINDINGS: Cells harboring splicing factor mutations have increased aberrant splicing leading to R-loop formation and cell cycle stalling that create dependencies on Checkpoint kinase 1 (CHK1) activation and canonical splicing maintained by protein arginine methyltransferase activity.	Arginine	255-263	SLU7 homolog, splicing factor	Homo sapiens	33-48
861226-5	1977	It appears from our studies that the tertiary structure of the moderately, arginine-rich histone (H2A) is an essential feature for its interaction with DNA.	Arginine	75-83	H2A clustered histone 18	Homo sapiens	98-101
33484949-10	2021	Endogenous and/or pharmacological and GPR120 agonists reduced somatostatin secretion in isolated islets and concomitantly demonstrated dose-dependent potentiation of glucose-stimulated insulin secretion and arginine-stimulated glucagon secretion.	Arginine	207-215	free fatty acid receptor 4	Mus musculus	38-44
33484949-10	2021	Endogenous and/or pharmacological and GPR120 agonists reduced somatostatin secretion in isolated islets and concomitantly demonstrated dose-dependent potentiation of glucose-stimulated insulin secretion and arginine-stimulated glucagon secretion.	Arginine	207-215	glucagon	Mus musculus	227-235
33420374-0	2021	PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.	Arginine	25-33	non-POU domain containing octamer binding	Homo sapiens	49-53
33453107-8	2021	Redox-based PTMs mostly occur in the cysteine thiol group (oxidation, S-nitrosylation, S-glutathionylation, persulfidation), but also in methionine (oxidation), tyrosine (nitration), and lysine and arginine (carbonylation/glycation) residues.	Arginine	198-206	parathymosin	Homo sapiens	12-16
942977-1	1976	Guinea pig eosinophil granules contain a protein, the major basic protein (MBP), which accounts for more than half of the total granule protein, has a high content of arginine, and displays a remarkable tendency to form disulfide-linked aggregates.	Arginine	167-175	myelin basic protein	Homo sapiens	54-73
33467558-5	2021	This model positions C4b near the Arg-Gly-Asp (RGD) loops of the penton base.	Arginine	34-37	complement C4B (Chido blood group)	Homo sapiens	21-24
942977-1	1976	Guinea pig eosinophil granules contain a protein, the major basic protein (MBP), which accounts for more than half of the total granule protein, has a high content of arginine, and displays a remarkable tendency to form disulfide-linked aggregates.	Arginine	167-175	myelin basic protein	Homo sapiens	75-78
33410556-7	2021	Additions of Arg or Cit to the LP at both levels resulted in increased BWG and reduced FCR (p < 0.05).	Arginine	13-16	FCR	Gallus gallus	87-90
942977-6	1976	The human MBP had a molecular weight of 9,200, contained less than 1% carbohydrate, was rich in arginine, and readily formed disulfide-bonded aggregates.	Arginine	96-104	myelin basic protein	Homo sapiens	10-13
50378-2	1975	Of the three major groups of non-mineral components examined, amino acid solution played a major role; when individual amino acids were examined using the double antibody technique, arginine was found to interfere predominantly; its dose-response curve was parallel to that of rat AFP, which confirmed that an immunological identity between two substances cannot be established on the basis of parallelism as the only criterion.	Arginine	182-190	alpha-fetoprotein	Rattus norvegicus	281-284
1141204-15	1975	Intracellular concentrations of seven amino acids, including threonine, serine, proline, glycine, alanine, lysine, and arginine, were increased significantly in livers perfused with medium containing growth hormone...	Arginine	119-127	gonadotropin releasing hormone receptor	Rattus norvegicus	200-214
33319872-8	2021	With an extensive analysis of intermolecular residue-residue interactions we discovered that arginine is of paramount importance in the initial stage of aggregation of HEWL and gamma-D crystallin, meanwhile lysine was found to be the most involved amino acid in forming initial contacts between T4 WT* molecules.	Arginine	93-101	crystallin gamma D	Homo sapiens	177-195
33402116-11	2021	We found that miR-205, one of the DEMs, was negatively regulated the expression of ARG (NKX2-3).	Arginine	83-86	microRNA 205	Homo sapiens	14-21
16658502-5	1973	Argininosuccinate lyase activity appeared to be enhanced, when arginine levels were increased above those occurring physiologically.	Arginine	63-71	argininosuccinate lyase, chloroplastic	Glycine max	0-23
33402116-18	2021	MiR-205 was negatively regulated the expression of ARG (NKX2-3).	Arginine	51-54	microRNA 205	Homo sapiens	0-7
33402116-20	2021	CONCLUSIONS: The current study may offer a novel autophagy-related prognostic signature and may identify a promising miRNA-ARG pathway for predicting the efficacy of anti-PD-1 therapy in PCa.	Arginine	123-126	programmed cell death 1	Homo sapiens	171-175
32853530-11	2021	In turn, L-arginine (nitric oxide donor) was able to enhance orofacial pain by upregulating CGRP expressions in vivo.	Arginine	9-19	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
4229624-0	1966	[Activity of plasmin and streptokinase-activator on substituted arginine and lysine esters].	Arginine	64-72	plasminogen	Homo sapiens	13-20
32853530-12	2021	In cultured trigeminal neurons, L-arginine upregulated the expression of CGRP, and this effect was diminished by cilnidipine (N-type calcium channel blocker) while not by mibefradil (L-type calcium channel blocker).	Arginine	32-42	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
33277752-9	2021	A high insulin response was associated with lower arginine (adjusted P-value = .02) and carnitine (adjusted P-value = .03) concentrations.	Arginine	50-58	INS	Equus caballus	7-14
33277752-12	2021	Plasma arginine and carnitine concentrations were lower in horses with high insulin response and could constitute potential therapeutic targets.	Arginine	7-15	INS	Equus caballus	76-83
34016143-9	2021	Moreover, the model captures the exquisite interactions of leucine, sestrin2, and arginine, and the resulting signal to the mTORC1 pathway.	Arginine	82-90	CREB regulated transcription coactivator 1	Mus musculus	124-130
33335114-6	2020	Utilizing targeted mass spectrometry (MS), methods were developed to detect and quantitate changes in methylation of specific arginine residues on hnRNP-A1.	Arginine	126-134	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	147-155
34022192-7	2021	Since two arginine residues -ARG19 and ARG22-were identified to be common for the interaction with CIDEA, a single-point mutation was induced in these residues to determine whether they are important for binding interaction.	Arginine	10-18	cell death inducing DFFA like effector a	Homo sapiens	99-104
33402546-2	2020	Nitric oxide (NO), a free gas with multitudinous bioactivities, is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase (nNOS) in the brain.	Arginine	105-115	nitric oxide synthase 1	Homo sapiens	119-149
33402546-2	2020	Nitric oxide (NO), a free gas with multitudinous bioactivities, is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase (nNOS) in the brain.	Arginine	105-115	nitric oxide synthase 1	Homo sapiens	151-155
33291073-2	2020	Serine arginine protein kinase 1 (SRPK1) is responsible for the phosphorylation of serine/arginine (SR)-rich proteins.	Arginine	7-15	SRSF protein kinase 1	Homo sapiens	34-39
32336525-10	2020	SNAT4, 4hFC, LAT2 mRNA were up-regulated in LP + CIT and LP + ARG group compared with the un-supplemented LP group.	Arginine	62-65	linker for activation of T cells family, member 2	Rattus norvegicus	13-17
32725514-0	2020	IFN-gamma Activates the TLR4-CCL5 Signaling Through Reducing Arginine Level, Leading to Enhanced Susceptibility of Bovine Mammary Epithelial Cells to Staphylococcus aureus.	Arginine	61-69	C-C motif chemokine 5	Bos taurus	29-33
32725514-5	2020	IFN-gamma increased the activity of arginase II and reduced the level of arginine in cells, while the addition of arginine inhibited the expression of TLR4 and CCL5.	Arginine	114-122	C-C motif chemokine 5	Bos taurus	160-164
32866611-2	2020	CLK1 belongs to the CLK kinase family that regulates alternative splicing through phosphorylation of serine-arginine rich (SR) proteins.	Arginine	108-116	CDC like kinase 1	Homo sapiens	0-4
33073687-6	2020	Binding domain mapping showed that the arginine-rich N-terminal motif 1MTYPRRRYRRRRHRPRSHLG20 of Cap, and residue serine-48 of the N-terminal oligomerization domain of NPM1, are essential for the interaction.	Arginine	39-47	nucleophosmin 1	Homo sapiens	168-172
33191336-14	2020	MiR-324/SOCS3 axis could improve the H/R-induced injury of cardiomyocytes via regulating TNF/NF-kappaB signaling pathway, and this might provide a new therapy strategy for myocardial ischemia.	Arginine	2-3	suppressor of cytokine signaling 3	Homo sapiens	8-13
33170672-3	2020	Nearly 30 years ago, a theoretical arginine fork model was posited to account for the specificity between the HIV-1 Tat protein and TAR RNA.	Arginine	35-43	tyrosine aminotransferase	Homo sapiens	116-119
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	36-39	neuropilin 1	Homo sapiens	158-170
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	36-39	neuropilin 1	Homo sapiens	172-176
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	40-43	neuropilin 1	Homo sapiens	158-170
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	40-43	neuropilin 1	Homo sapiens	172-176
33047125-1	2020	This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2 and SLC6A14 in mammary parenchymal tissue.	Arginine	74-77	solute carrier family 7 member 2	Homo sapiens	185-191
32891072-5	2020	Suppressing polar auxin transport, either by pharmacological treatment or by introducing mutations at PIN-FORMED2 (PIN2) or AUXIN RESISTANT1 (AUX1), suppressed the asymmetric root growth (ARG) in fer-4, a null mutant of FER, indicating that FER-suppression of ARG depends on polar auxin transport.	Arginine	188-191	Auxin efflux carrier family protein	Arabidopsis thaliana	102-113
32891072-5	2020	Suppressing polar auxin transport, either by pharmacological treatment or by introducing mutations at PIN-FORMED2 (PIN2) or AUXIN RESISTANT1 (AUX1), suppressed the asymmetric root growth (ARG) in fer-4, a null mutant of FER, indicating that FER-suppression of ARG depends on polar auxin transport.	Arginine	188-191	Auxin efflux carrier family protein	Arabidopsis thaliana	115-119
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	arginase 1	Homo sapiens	84-94
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	arginase 1	Homo sapiens	96-100
33162891-6	2020	We found 25 such arginine residues, including 2 in the spike protein and 10 in the nucleoprotein.	Arginine	17-25	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-60
32960212-8	2020	PRMT5-induced symmetrical di-methylation of arginine residues of hnRNP A1 enabled the ITAF to stimulate the HIV-1 and HTLV-1 IRESs while reducing the stimulatory ability of the ITAF over the MMTV IRES.	Arginine	44-52	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	65-73
32569665-6	2020	On the other hand, when NO synthesis is increased by protein synthesis inhibition with cycloheximide or addition of exogenous L-arginine, eEF2K has no participation, showcasing a specific link between this enzyme and NMDA-induced NO signaling.	Arginine	126-136	eukaryotic elongation factor 2 kinase	Homo sapiens	138-143
32569665-9	2020	In summary, we demonstrated here a new role for eEF2K, directly controlling NMDA-dependent nitrergic signaling and modulating L-arginine availability in neurons, which can potentially be a new target for the study of physiological and pathological processes involving NMDA receptors in the central nervous system.	Arginine	126-136	eukaryotic elongation factor 2 kinase	Homo sapiens	48-53
32418491-1	2020	Arginase-1, which converts the amino acid L-arginine into L-ornithine and urea, is a promising new drug target for cancer immunotherapy, as it has a role in the regulation of T-cell immunity in the tumor microenvironment.	Arginine	42-52	arginase 1	Homo sapiens	0-10
32995772-3	2020	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	furin, paired basic amino acid cleaving enzyme	Homo sapiens	4-9
32995772-3	2020	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	41-46
32780724-7	2020	High levels of arginase-1 in Tim-4+ TAMs contributed to potent mitophagy activities via weakened mTORC1 activation due to low arginine resultant from arginase-1-mediated metabolism.	Arginine	126-134	arginase 1	Homo sapiens	15-25
32762558-6	2020	We used transgenic expression of dimethylarginine dimethylaminohydrolase 1 (DDAH), which degrades methylated arginines, to investigate their contribution to exercise-induced fatigue in DMD.	Arginine	109-118	dimethylarginine dimethylaminohydrolase 1	Mus musculus	33-74
32762558-6	2020	We used transgenic expression of dimethylarginine dimethylaminohydrolase 1 (DDAH), which degrades methylated arginines, to investigate their contribution to exercise-induced fatigue in DMD.	Arginine	109-118	dimethylarginine dimethylaminohydrolase 1	Mus musculus	76-80
32721242-1	2020	Background: Arginase I, encoded by the ARG1 gene, is an enzyme that catalyzes the conversion of arginine to ornithine in the urea cycle; mutations in this gene has recently been reported to be associated with dilated cardiomyopathy (DCM) in Pakistan.	Arginine	96-104	arginase 1	Homo sapiens	39-43
33526384-4	2021	We introduced the human mesotrypsin evolutionary signature mutation into mouse cationic trypsinogen (isoform T7), resulting in a Gly to Arg change at the corresponding position 199.	Arginine	136-139	serine protease 3	Homo sapiens	24-35
33328312-0	2021	The Substantial Attenuation of Virulence of Tembusu Virus Strain PS Is Determined by an Arg at Residue 304 of the Envelope Protein.	Arginine	88-91	endogenous retrovirus group K member 6, envelope	Homo sapiens	114-130
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	transforming growth factor, beta 1	Mus musculus	229-238
33594316-10	2021	Therefore, BBR protects H/R-treated cardiomyocytes from apoptosis by inhibiting the TGF-beta/Smad4 signaling pathway.	Arginine	13-14	transforming growth factor alpha	Homo sapiens	84-92
33594316-10	2021	Therefore, BBR protects H/R-treated cardiomyocytes from apoptosis by inhibiting the TGF-beta/Smad4 signaling pathway.	Arginine	13-14	SMAD family member 4	Homo sapiens	93-98
33536412-0	2021	Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact.	Arginine	10-18	synaptotagmin 1	Homo sapiens	31-46
33539881-3	2021	We have recently demonstrated that in addition to acetyl-lysine binding, the BRG1/BRM bromodomain can associate with DNA through a lysine/arginine rich patch that is adjacent to the acetyl-lysine binding pocket.	Arginine	138-146	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	77-81
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Arginine	21-29	Ypq2p	Saccharomyces cerevisiae S288C	70-74
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Arginine	44-52	Ypq2p	Saccharomyces cerevisiae S288C	70-74
33290345-6	2021	The antidepressant-like effect of carbamazepine (40 mg/kg, intraperitoneal) was prevented by pretreatment with L-arginine [substrate for NO synthase (NOS), 750 mg/kg, intraperitoneal], sildenafil (a PDE-5 inhibitor, 5 mg/kg, intraperitoneal) and diazoxide (K channels opener, 10 mg/kg).	Arginine	111-121	nitric oxide synthase 1, neuronal	Mus musculus	137-148
32605511-8	2021	Silencing of BCL2L11 and caspase-2 both, respectively, counteracted the H9c2 cell injury caused by H/R treatment.	Arginine	101-102	caspase 2	Rattus norvegicus	25-34
33978350-14	2021	CONCLUSIONS: Although we found only trends of improvements of perinatal outcomes in LDA+LArg group, considering the promising results on BP values, uterine artery PI and the low need to start a new antihypertensive treatment, thus the resulting impact in reducing pregnancy medicalization, number of maternal-fetal well-being monitoring visits and the need of induction of labour, we believe that further studies should be performed to enlarge our observation and clarify the role of L-Arg 3g supplementation as a protective integration in high-risk pregnancies already in prophylaxis with LDA.	Arginine	484-489	Rho guanine nucleotide exchange factor 12	Homo sapiens	88-92
33499404-1	2021	Nitric oxide (NO) is formed during the oxidation of L-arginine to L-citrulline by the action of multiple isoenzymes of NO synthase (NOS): neuronal NOS (nNOS), endotelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	52-62	nitric oxide synthase 1	Homo sapiens	138-150
34046031-3	2021	Coordinated arginine metabolism through arginase 1 (Arg1) is critical for brain myeloid cells to perform biological functions, whereas dysregulated arginine metabolism disrupts them.	Arginine	12-20	arginase, liver	Mus musculus	40-50
33307682-8	2021	Computational modeling identified a likely mode of interaction of the negatively charged side chain in GLP-1-CYA with an arginine on GLP-1R.	Arginine	121-129	glucagon like peptide 1 receptor	Homo sapiens	133-139
33202281-8	2021	RESULTS: l-arginine group displayed AP as manifested by a significant increase in serum lipase and amylase, MDA, NOx, IL-6, TNF-alpha, caspase-3 with iNOS immuno-expression.	Arginine	9-19	caspase 3	Rattus norvegicus	135-144
32157557-0	2020	Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival.	Arginine	0-8	ribose 5-phosphate isomerase A	Homo sapiens	24-54
32157557-4	2020	Here we show that ribose-5-phosphate isomerase A (RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1 (CARM1) and is methylated at arginine 42 (R42).	Arginine	123-131	ribose 5-phosphate isomerase A	Homo sapiens	18-48
32157557-4	2020	Here we show that ribose-5-phosphate isomerase A (RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1 (CARM1) and is methylated at arginine 42 (R42).	Arginine	123-131	ribose 5-phosphate isomerase A	Homo sapiens	50-54
34046031-3	2021	Coordinated arginine metabolism through arginase 1 (Arg1) is critical for brain myeloid cells to perform biological functions, whereas dysregulated arginine metabolism disrupts them.	Arginine	12-20	arginase, liver	Mus musculus	52-56
33043402-10	2021	Diphtheria toxin-induced knockdown of glucagon producing cells led to reduced somatostatin secretion in response to 12 mmol/l glucose and arginine infusions.	Arginine	138-146	glucagon	Mus musculus	38-46
33955040-11	2021	Sequence analysis of the mutant PEX1 D2 domain revealed that mutation p. Arg949Trp precisely occurred in a conserved arginine residue (P4 Arg), which hinders the substrate processing of the complex.	Arginine	117-125	peroxisomal biogenesis factor 1	Homo sapiens	32-36
33043402-12	2021	However, infusion of exendin 9-39 in Gcgr-/- mice completely abolished somatostatin secretion in response to glucose and arginine.	Arginine	121-129	glucagon receptor	Mus musculus	37-41
33025106-6	2021	Moreover, immunosuppressive cells suppress the function of effector immune cells by catabolizing L-arginine and tryptophan through the activation of arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO), respectively.	Arginine	97-107	arginase 1	Homo sapiens	149-159
32878254-16	2020	The jejunum gene expression of toll-like receptor-4 was upregulated in the Con and ARG treatments compared with the ZnArg1 and ZnArg3.	Arginine	83-86	toll like receptor 4	Sus scrofa	31-51
33025106-6	2021	Moreover, immunosuppressive cells suppress the function of effector immune cells by catabolizing L-arginine and tryptophan through the activation of arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO), respectively.	Arginine	97-107	arginase 1	Homo sapiens	161-165
33955040-11	2021	Sequence analysis of the mutant PEX1 D2 domain revealed that mutation p. Arg949Trp precisely occurred in a conserved arginine residue (P4 Arg), which hinders the substrate processing of the complex.	Arginine	73-76	peroxisomal biogenesis factor 1	Homo sapiens	32-36
33296665-2	2021	Recently, SLC38A9, a lysosomal amino acid transporter, emerged as a sensor for luminal arginine and as an activator of mTORC1.	Arginine	87-95	solute carrier family 38 member 9	Danio rerio	10-17
33378328-10	2020	Gcn4 directly binds promoter-regions and transcribes a subset of metabolic genes, particularly driving lysine and arginine biosynthesis.	Arginine	114-122	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	0-4
33378328-11	2020	Gcn4 also globally represses lysine and arginine enriched transcripts, which include genes encoding the translation machinery.	Arginine	40-48	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	0-4
33296665-4	2021	Here, we determined the crystal structure of zebrafish SLC38A9 (drSLC38A9) and found the N-terminal fragment inserted deep within the transporter, bound in the substrate-binding pocket where normally arginine would bind.	Arginine	200-208	solute carrier family 38 member 9	Danio rerio	55-62
33296665-4	2021	Here, we determined the crystal structure of zebrafish SLC38A9 (drSLC38A9) and found the N-terminal fragment inserted deep within the transporter, bound in the substrate-binding pocket where normally arginine would bind.	Arginine	200-208	solute carrier family 38 member 9	Danio rerio	64-73
33296665-5	2021	This represents a significant conformational change of the N-terminal domain (N-plug) when compared with our recent arginine-bound structure of drSLC38A9.	Arginine	116-124	solute carrier family 38 member 9	Danio rerio	144-153
33423731-1	2020	Kidney is one of the important organs of the body.With both excretory and endocrine functions,it plays a vital role in regulating the normal physiological state.As a precursor of the nitric oxide(NO)synthesis in vivo,L-arginine is involved in intracellular and intercellular signaling via NO,a vasoactive factor,thus plays a key role in maintaining the normal physiological functions of the kidney.Alpha1-adrenergic receptor(alpha1-AR)mediates sympathetic nerves to regulate the heart,blood vessels,and nervous system of the body.The alpha1-AR distributed in vascular smooth muscle mainly mediates vasoconstriction.The responsiveness of alpha1-AR to adrenergic agonists decreases in rat models of kidney failure,diabetes,hypertension,and left ventricular hypertrophy,which affects the hemodynamic state and vascular tone of the kidney.Here we analyze the ways via which L-arginine improves the responsiveness of alpha1-AR to its agonists by ellucidating the action mode of NO/alpha1-AR and their effects on renal functions.	Arginine	217-227	ferredoxin reductase	Rattus norvegicus	432-434
33296665-6	2021	We propose a ball-and-chain model for mTORC1 activation, where N-plug insertion and Rag GTPase binding with SLC38A9 is regulated by luminal arginine levels.	Arginine	140-148	CREB regulated transcription coactivator 1	Mus musculus	38-44
33296665-6	2021	We propose a ball-and-chain model for mTORC1 activation, where N-plug insertion and Rag GTPase binding with SLC38A9 is regulated by luminal arginine levels.	Arginine	140-148	solute carrier family 38 member 9	Danio rerio	108-115
33951695-4	2021	Overexpression of miR-129-5p through transfection of miR-129-5p mimics effectively improved cell viability and reduced lactate dehydrogenase release in H9c2 cells exposed to H/R, along with decreased apoptosis and caspase-3 activities.	Arginine	20-21	caspase 3	Rattus norvegicus	214-223
33325825-0	2020	Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.	Arginine	51-59	Ras homolog, mTORC1 binding	Homo sapiens	28-32
33010592-5	2020	The SBC exposed to Ag2S NPs showed a significative decrease of functional parameters, such as beta-glucosidase activity and L-arginine consumption, and increase of the acid phosphatase activity.	Arginine	124-134	angiotensin II receptor type 1	Homo sapiens	19-23
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	autophagy related 4B cysteine peptidase	Homo sapiens	114-119
32961195-0	2020	Effect of arginine on stability and aggregation of muscle glycogen phosphorylase b.	Arginine	10-18	prohibitin 1	Homo sapiens	67-82
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	protein kinase C delta	Homo sapiens	162-167
33925460-8	2021	RESULTS: Our study identified an 11-gene ARG signature that is significantly associated with OS, including APOL1, ATG4B, BAG1, CASP3, DRAM1, ITGA3, KLHL24, P4HB, PRKCD, ULK2, and WDR45.	Arginine	41-44	unc-51 like autophagy activating kinase 2	Homo sapiens	169-173
33884581-0	2021	The Antipsychotic Drug Clozapine Suppresses the RGS4 Polyubiquitylation and Proteasomal Degradation Mediated by the Arg/N-Degron Pathway.	Arginine	116-119	regulator of G protein signaling 4	Homo sapiens	48-52
33323039-8	2020	The ARG and ASN were found to be important residues of REV.	Arginine	4-7	Rev	Human immunodeficiency virus 1	55-58
32967969-10	2020	A mutant GCGR with all five intracellular lysines altered to arginines remains deubiquitinated, and shows augmented trafficking to Rab4a recycling endosomes compared with the WT, thus affirming the role of deubiquitination in GCGR recycling.	Arginine	61-70	glucagon receptor	Homo sapiens	9-13
33927720-10	2021	Results showed that ATG16L, as one significant differential ARG, was less expressed in CAD group compared to the non-CAD group.	Arginine	60-63	autophagy related 16 like 1	Homo sapiens	20-26
32980186-2	2021	As tree nuts and groundnuts are a source of the amino acid l-arginine, we performed a meta-analysis of human randomized controlled trials (RCTs) to compare effects of tree nut and groundnut consumption with those of l-arginine supplementation on fasting and postprandial endothelial function as assessed by flow-mediated vasodilation of the brachial artery (FMD).	Arginine	59-69	NUT midline carcinoma family member 1	Homo sapiens	8-11
32980952-1	2020	Cationic amino acid transporter 1 (Cat-1 alias Slc7a1) is a Na+-independent carrier system involved in transport and absorption of the cationic amino acids lysine, arginine, histidine, and ornithine and has also been shown to be indispensable in a large variety of biological processes.	Arginine	164-172	solute carrier family 7 member 1a	Danio rerio	47-53
33869228-4	2021	Furthermore, we studied whether autophagy inhibition may be the mechanism underlying the previously reported improvement of peroxisomal functions by L-arginine in PEX1-G843D cells.	Arginine	149-159	peroxisomal biogenesis factor 1	Homo sapiens	163-167
33135877-2	2020	Among them, l-arginine is the substrate for nitric oxide synthases (NOS) to produce nitric oxide (NO), a key signaling molecule and second messenger.	Arginine	12-22	nitric oxide synthase 1, neuronal	Mus musculus	44-66
33868281-12	2021	Molecular analysis of MICA-181 showed that the presence of threonine provides greater mobility to the protein than arginine in the same position (MICA*004), which could explain, at least in part, some immune evasion mechanisms developed by the tumor.	Arginine	115-123	MHC class I polypeptide-related sequence A	Homo sapiens	22-26
33106423-8	2020	Binding to Scap requires an arginine residue in exon 18 of SREBP2.	Arginine	28-36	SREBF chaperone	Homo sapiens	11-15
33868281-12	2021	Molecular analysis of MICA-181 showed that the presence of threonine provides greater mobility to the protein than arginine in the same position (MICA*004), which could explain, at least in part, some immune evasion mechanisms developed by the tumor.	Arginine	115-123	MHC class I polypeptide-related sequence A	Homo sapiens	146-150
33437999-6	2021	RESULTS: : GAA and creatine syntheses were 115% and 32% higher, respectively, with the +Arg/Met diet (P < 0.0001), in spite of 33% lower renal L-arginine: glycine amidinotransferase activity (P < 0.0001) compared to Base, suggesting substrate availability dictates synthesis rather than enzyme capacity.	Arginine	88-91	alpha glucosidase	Homo sapiens	11-14
33046551-6	2020	The extent of inhibition is also dependent on charge at site 607, the site that undergoes RNA editing in GluA2 subunits replacing glutamine to arginine, with the percent inhibition being lower and IC50 being higher for the edited GluA2(R) relative to unedited GluA2(Q) and to GluA2(Q607E), a mutation observed in the genetic screen of a patient exhibiting developmental delays.	Arginine	143-151	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	105-110
33046551-6	2020	The extent of inhibition is also dependent on charge at site 607, the site that undergoes RNA editing in GluA2 subunits replacing glutamine to arginine, with the percent inhibition being lower and IC50 being higher for the edited GluA2(R) relative to unedited GluA2(Q) and to GluA2(Q607E), a mutation observed in the genetic screen of a patient exhibiting developmental delays.	Arginine	143-151	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	230-235
33437999-7	2021	GAA or creatine supplementation reduced arginine conversion to creatine by 46% and 43%, respectively (P < 0.01), but did not spare amino acids for whole-body protein synthesis, suggesting that limited amino acids were diverted to protein at the expense of creatine synthesis.	Arginine	40-48	alpha glucosidase	Homo sapiens	0-3
33046551-6	2020	The extent of inhibition is also dependent on charge at site 607, the site that undergoes RNA editing in GluA2 subunits replacing glutamine to arginine, with the percent inhibition being lower and IC50 being higher for the edited GluA2(R) relative to unedited GluA2(Q) and to GluA2(Q607E), a mutation observed in the genetic screen of a patient exhibiting developmental delays.	Arginine	143-151	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	230-235
33046551-6	2020	The extent of inhibition is also dependent on charge at site 607, the site that undergoes RNA editing in GluA2 subunits replacing glutamine to arginine, with the percent inhibition being lower and IC50 being higher for the edited GluA2(R) relative to unedited GluA2(Q) and to GluA2(Q607E), a mutation observed in the genetic screen of a patient exhibiting developmental delays.	Arginine	143-151	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	230-235
33684277-2	2021	In addition, the patient, his sister, mother and maternal grandfather had intermittently increased plasma arginine and lysine levels, most probably due to heterozygosity for a novel pathogenic SLC7A2 variant.	Arginine	106-114	solute carrier family 7 member 2	Homo sapiens	193-199
33158046-2	2020	cue1 mutants present an increased content of arginine, a precursor of NO in oxidative synthesis processes.	Arginine	45-53	Glucose-6-phosphate/phosphate translocator-like protein	Arabidopsis thaliana	0-4
33688625-3	2021	Using CRISPR-Cas9, our lab generated a C. elegans model for Saul-Wilson Syndrome by recreating the same glycine-to-arginine substitution in the worm ortholog cogc-4.	Arginine	115-123	Conserved oligomeric Golgi complex subunit 4	Caenorhabditis elegans	158-164
32721946-1	2020	Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects.	Arginine	34-44	arginase, liver	Mus musculus	0-10
32721946-1	2020	Arginase 1 (Arg1), which converts L-arginine into ornithine and urea, exerts pleiotropic immunoregulatory effects.	Arginine	34-44	arginase, liver	Mus musculus	12-16
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	60-70	arginase, liver	Mus musculus	28-32
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	arginase, liver	Mus musculus	28-32
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	arginase, liver	Mus musculus	28-32
33711670-5	2021	With a few exceptions, brain tumors show increased activities of one or all of the three arginine (Arg) to NO-converting nitric oxide synthase (NOS) isoforms (iNOS, eNOS, nNOS), but also elevated activities of polyamines-generating and modifying enzymes: arginase I/II, ornithine decarboxylase and spermidine/spermine N1-acetyltransferase.	Arginine	99-102	ornithine decarboxylase 1	Homo sapiens	270-293
33398168-5	2021	Our structural research, complemented by binding assays and global protein stability (GPS) analyses, demonstrates that FEM1A/C and FEM1B selectively target distinct classes of Arg/C-degrons.	Arginine	176-179	fem-1 homolog A	Homo sapiens	119-126
33122522-0	2020	Inhibition of CHRM3 Alleviates Necrosis Via the MAPK-p38/miR-31-5p/RIP3 Axis in L-Arginine-Induced Severe Acute Pancreatitis.	Arginine	80-90	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	14-19
33122522-3	2020	This study revealed the important role of CHRM3 in regulating L-arginine-induced SAP and the molecular mechanisms.	Arginine	62-72	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	42-47
33122522-5	2020	RESULTS: In L-arginine-induced SAP, CHRM3 is activated and regulates SAP through the mitogen-activated protein kinase/p38 pathway.	Arginine	12-22	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	36-41
33122522-5	2020	RESULTS: In L-arginine-induced SAP, CHRM3 is activated and regulates SAP through the mitogen-activated protein kinase/p38 pathway.	Arginine	12-22	mitogen-activated protein kinase 14	Mus musculus	118-121
33122522-8	2020	CONCLUSIONS: Necrosis in L-arginine-induced SAP is promoted by CHRM3 through the mitogen-activated protein kinase-p38/miR-31-5p/RIP3 axis.	Arginine	25-35	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	63-68
33398170-3	2021	FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive.	Arginine	63-71	fem-1 homolog C	Homo sapiens	0-5
33398170-3	2021	FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive.	Arginine	80-83	fem-1 homolog C	Homo sapiens	0-5
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	61-64	fem-1 homolog C	Homo sapiens	39-44
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	61-64	fem-1 homolog C	Homo sapiens	88-93
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	61-64	fem-1 homolog C	Homo sapiens	88-93
32828530-6	2020	On the contrary, the depletion of GSKIP enhanced the sensitivity of cardiomyocytes to H/R-induced injury.	Arginine	88-89	GSK3B interacting protein	Homo sapiens	34-39
32828530-8	2020	Interestingly, inhibition of GSK-3beta by a chemical inhibitor markedly enhanced Nrf2/ARE activation and abrogated GSKIP depletion-exacerbated sensitivity to H/R-induced injury.	Arginine	87-88	glycogen synthase kinase 3 alpha	Homo sapiens	29-38
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	156-164	fem-1 homolog C	Homo sapiens	39-44
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	156-164	fem-1 homolog C	Homo sapiens	88-93
33192289-1	2020	Neuronal nitric oxide synthase (nNOS), an enzyme required for learning and memory, catalyzes L-arginine decomposition during nitric oxide production in mammalian neurons.	Arginine	93-103	nitric oxide synthase 1	Homo sapiens	0-30
33192289-1	2020	Neuronal nitric oxide synthase (nNOS), an enzyme required for learning and memory, catalyzes L-arginine decomposition during nitric oxide production in mammalian neurons.	Arginine	93-103	nitric oxide synthase 1	Homo sapiens	32-36
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	156-164	fem-1 homolog C	Homo sapiens	88-93
33097830-0	2020	Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b.	Arginine	10-20	CREB regulated transcription coactivator 1	Mus musculus	99-105
33398170-4	2021	Here, we present crystal structures of FEM1C in complex with Arg/C-degron and show that FEM1C utilizes a semi-open binding pocket to capture the C-terminal arginine and that the extreme C-terminal arginine is the major structural determinant in recognition by FEM1C.	Arginine	197-205	fem-1 homolog C	Homo sapiens	39-44
33097830-6	2020	Mechanistically, we find that L-arginine stimulates Wnt2b secretion by CD90+ stromal cells through the mammalian target of rapamycin complex 1 (mTORC1) and that blocking Wnt2b production prevents L-arginine-induced ISC expansion.	Arginine	30-40	CREB regulated transcription coactivator 1	Mus musculus	144-150
32644793-4	2020	Activation of nNOS by l-arginine led to depressive behaviors, and inhibition of nNOS contributed to antidepressive behaviors.	Arginine	22-32	nitric oxide synthase 1, neuronal	Mus musculus	14-18
33338599-0	2021	Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.	Arginine	0-8	ubiquitin	Bos taurus	70-79
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	0-31
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	angiotensin converting enzyme 2	Homo sapiens	33-38
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	kallikrein B1	Homo sapiens	63-80
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	150-158	kallikrein B1	Homo sapiens	82-87
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	angiotensin converting enzyme 2	Homo sapiens	0-31
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	kallikrein B1	Homo sapiens	63-80
33001648-3	2020	Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site.	Arginine	159-167	kallikrein B1	Homo sapiens	82-87
33092030-6	2020	From these results, formation of oxidative stress and 8-OHdG in the DNA and elevation of glucose metabolites and L-arginine due to ARG1 suppression in mice liver cells are the important characteristics of T2DM/NASH-associated hepatocarcinogenesis, which may take part in activating oxidative stress resistance, synthesis of phosphocreatine, cell signaling, methylation, and proliferation.	Arginine	113-123	arginase, liver	Mus musculus	131-135
32581101-3	2020	Here, we show that a highly conserved arginine residue in the C-terminal domain of diverse HPV E7 mediates the interaction with PTPN14.	Arginine	38-46	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	128-134
33242037-7	2021	Hence, a visible difference in fluorescence enhancement for l-PA and d-PA and excellent enantioselective behavior between S-1 and l-PA (or R-1 and d-PA) was displayed.	Arginine	139-140	lipoprotein(a)	Homo sapiens	60-64
32581101-6	2020	Now, we have found that blocking PTPN14 binding through mutation of the conserved C-terminal arginine rendered both HPV16 and HPV18 E7 unable to repress differentiation-related gene expression.	Arginine	93-101	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	33-39
32581101-12	2020	PTPN14 binds to a C-terminal arginine highly conserved in diverse HPV E7.	Arginine	29-37	protein tyrosine phosphatase non-receptor type 14	Homo sapiens	0-6
32830871-10	2020	Collectively, arginine-rich DPR-mediated impairment of EXOSC10 and the RNA exosome complex compromises repeat RNA metabolism and may thus exacerbate C9orf72-FTLD/ALS pathologies in a vicious cycle.	Arginine	14-22	C9orf72-SMCR8 complex subunit	Homo sapiens	149-156
33242037-7	2021	Hence, a visible difference in fluorescence enhancement for l-PA and d-PA and excellent enantioselective behavior between S-1 and l-PA (or R-1 and d-PA) was displayed.	Arginine	139-140	lipoprotein(a)	Homo sapiens	130-134
32785674-0	2021	RNA-recognition motifs and glycine and arginine-rich region cooperatively regulate the nucleolar localization of nucleolin.	Arginine	39-47	nucleolin	Homo sapiens	113-122
32900932-9	2020	In cells expressing Msh3 in which these lysine residues are mutated to arginine, the inhibitory effect of RGFP966 on expansions is largely bypassed, consistent with the direct deacetylation hypothesis.	Arginine	71-79	mutS homolog 3	Homo sapiens	20-24
32995289-5	2020	The PCCA gene sequencing revealed a novel homozygous missense variant affecting the locus (chr13:100962160) of exon 16 of the PCCA gene, resulting in the substitution of the amino acid arginine with proline at site 476 (p.Arg476Pro).	Arginine	185-193	propionyl-CoA carboxylase subunit alpha	Homo sapiens	4-8
32995289-5	2020	The PCCA gene sequencing revealed a novel homozygous missense variant affecting the locus (chr13:100962160) of exon 16 of the PCCA gene, resulting in the substitution of the amino acid arginine with proline at site 476 (p.Arg476Pro).	Arginine	185-193	propionyl-CoA carboxylase subunit alpha	Homo sapiens	126-130
32583741-0	2020	SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.	Arginine	6-14	SCY1 like pseudokinase 1	Homo sapiens	0-5
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	SCY1 like pseudokinase 1	Homo sapiens	52-57
33575089-7	2021	Similar changes on P4HA1 expression, the concentration of L-Arg and NO were observed when the expression of nNOS was disrupted.	Arginine	58-63	nitric oxide synthase 1	Homo sapiens	108-112
32304783-6	2020	The codon AGA (arginine) was found to be overrepresented in GALC gene, except for galactocerebrosidase isoform a precursor.	Arginine	15-23	galactocerebrosidase	Meleagris gallopavo	60-64
32947834-5	2020	Furthermore, an analysis of the amino acid composition indicated that the silk fibroin suffered less damage because papain specifically cleaved the binding sites between L-arginine or L-lysine residue and another amino acid residue in sericin, leading to a significantly higher molecular weight and improved tensile strength compared to traditional sodium carbonate degumming.	Arginine	170-180	fibroin light chain	Bombyx mori	79-86
33165673-8	2021	CONCLUSIONS: miR-19a eliminates the H/R-induced injury in cardiomyocytes through directly targeting CCL20 and attenuating the activity of MAPK signaling pathway.	Arginine	15-16	C-C motif chemokine ligand 20	Homo sapiens	100-105
32820515-5	2020	RESULTS: Sanger sequencing revealed that the patient has carried homozygous variant c.1486C>T in the exon 8 of the CYP17A1 gene, which resulted in substitution of arginine by cysteine (p.Arg496Cys).	Arginine	163-171	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	115-122
32754051-5	2020	L-arginine treatment during 7 days of rat HS prevented HS-induced NO content decrease and slow MyHC mRNA transcription decrease and attenuated fast MyHC IIb mRNA transcription increase; it also prevented NFATc1 nuclear content decrease, calsarcin-2 expression increase, and GSK-3beta Ser 9 phosphorylation decrease.	Arginine	0-10	glycogen synthase kinase 3 alpha	Rattus norvegicus	274-283
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Arginine	211-219	pyruvate dehydrogenase kinase 3	Homo sapiens	38-49
32620797-0	2020	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.	Arginine	8-16	C9orf72-SMCR8 complex subunit	Homo sapiens	0-7
32711445-9	2020	RESULTS: Administration of L-arginine to cisplatin-treated rats induced significant decrease in the average ABR threshold shifts at all frequencies, tissue TGF-beta1, TNF-alpha and IL-15 associated with significant increase in tissue antioxidant enzymes, total nitrate/nitrite and Nrf2/HO-1 content compared to cisplatin group.	Arginine	27-37	interleukin 15	Rattus norvegicus	181-186
33013410-0	2020	Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity.	Arginine	48-56	C9orf72-SMCR8 complex subunit	Homo sapiens	40-47
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Arginine	211-219	OIP5 antisense RNA 1	Homo sapiens	51-59
32227548-4	2020	The results showed that, compared with the saline treatment, arginine infusion increased plasma concentrations of insulin-like growth factor-I, arginine and cystine in the portal vein plasma, whereas plasma concentrations of threonine, serine, leucine and methionine were reduced.	Arginine	61-69	insulin like growth factor 1	Sus scrofa	114-142
33383100-9	2021	In erosion studies, SnF2 toothpastes provided an 83% benefit versus control toothpastes (arginine or sodium fluoride; p < 0.001) with a change (95%CI) in average surface profilometry level (microm) of -2.02(-2.85, -1.20).	Arginine	89-97	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	20-24
33120256-6	2021	Mobile genetic elements (Intl1 and tnpA) showed significant correlations with the abundance of ARGs.	Arginine	95-99	integrase	Escherichia coli	25-30
32125626-7	2020	The results showed that the arginine at position 643 caused electrostatic changes in neighboring regions, leading to the repulsion between the amino acids located in the catalytic cavity of the GAA enzyme, thus restricting access to its substrate.	Arginine	28-36	alpha glucosidase	Homo sapiens	194-197
33248687-0	2021	The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.	Arginine	14-22	sialic acid binding Ig like lectin 7	Homo sapiens	63-71
33248687-2	2021	Recently, a new Sia binding site in Siglec-7, termed site 2, where arginine (R) 67 was critical, was identified by computational modeling and biochemical analyses, relative to the primary Sia binding site, termed site 1, containing critical R124.	Arginine	67-75	sialic acid binding Ig like lectin 7	Homo sapiens	36-44
32891986-14	2021	Maternal dietary L-Arg supplementation significantly improved the expression of CPS1 gene, OTC gene (1.16%, 1.35%, and 1.55%), and ASS gene (1.35% and 1.55%) in the liver (P < 0.05), and also enhanced the CPS1 gene (except 1.35%) and OTC gene (1.55% and 1.74%) expression in the breast muscle (P < 0.05).	Arginine	17-22	argininosuccinate synthase 1	Gallus gallus	131-134
33162067-11	2021	We found that ASNS was upregulated in response to combined AA deprivation and by Arg deprivation alone by 3.6- and 4.51-fold, respectively, at 24 h of treatment.	Arginine	81-84	asparagine synthetase [glutamine-hydrolyzing]	Bos taurus	14-18
33162067-12	2021	We found that SLC7A1 was upregulated in response to combined AA deprivation and deprivation of Arg alone by 2.0- and 2.36-fold, respectively, at 8 h of treatment.	Arginine	95-98	solute carrier family 7 member 1	Bos taurus	14-20
32614387-5	2020	However we also found increased frequency of tumor stem cells in tumors from FVBArg+/-;Neu+/+ transgenic compared to FVBNeu+/+ mice, suggesting that increased arginine metabolism in mammary tumor microenvironment may supports the cancer stem cells niche.	Arginine	159-167	neuraminidase 1	Mus musculus	87-90
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	Bcl2-like 1	Rattus norvegicus	127-133
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	serpin family F member 1	Rattus norvegicus	0-4
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	serpin family F member 1	Rattus norvegicus	166-170
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	Bcl2-like 1	Rattus norvegicus	127-133
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	serpin family F member 1	Rattus norvegicus	166-170
34009196-5	2020	Results showed that the combined therapy (HU + L-Arginine) decreased SBP, DBP, MAP and PP (p <0.01 in each case) but increased %HbF, Hb and PCV (p< o.001 in each case).	Arginine	47-57	selenium binding protein 1	Homo sapiens	69-72
33378328-12	2020	The Gcn4 dependent lysine and arginine supply thereby maintains the synthesis of the translation machinery.	Arginine	30-38	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	4-8
33457206-6	2021	Arginine at position 72 plays a role in NFS1-ISD11 complex formation; therefore, its substitution with glutamine is expected to affect complex stability and function.	Arginine	0-8	NFS1 cysteine desulfurase	Homo sapiens	40-44
33128544-1	2020	Arginase I (ARG1) is a cytosolic enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea.	Arginine	73-83	arginase 1	Homo sapiens	12-16
33296397-0	2020	The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals.	Arginine	28-36	protein tyrosine phosphatase receptor type J	Homo sapiens	118-123
33296397-0	2020	The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals.	Arginine	28-36	protein tyrosine phosphatase receptor type J	Homo sapiens	124-128
33296397-3	2020	Previously, it was demonstrated that the N-terminally extended signal peptide of the human PTPRJ contains a cluster of arginine residues, which attenuates translation.	Arginine	119-127	protein tyrosine phosphatase receptor type J	Homo sapiens	91-96
33296397-5	2020	The PTPRJ transcripts in placentals, marsupials, and monotremes encode a stretch of 10-14 arginine residues, positioned 11-12 codons downstream of the initiating AUG.	Arginine	90-98	protein tyrosine phosphatase receptor type J	Homo sapiens	4-9
33296397-6	2020	The remarkable conservation of the repeated arginine residues in the PTPRJ signal peptides points to their key role.	Arginine	44-52	protein tyrosine phosphatase receptor type J	Homo sapiens	69-74
33169770-1	2020	Water-dispersed gold nanoparticles decorated with an amphiphilic cyclotetrasiloxane scaffold hold promise for the catalytic transformation of diorganosilanes to tetraorganodisiloxane-1,3-diols, (RR1SiOH)2O [R = Me or Ph R1 = Ph, cyclo-Hex] via en route formation of a Pickering emulsion.	Arginine	195-196	hematopoietically expressed homeobox	Homo sapiens	235-238
33302555-3	2020	In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y+L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing.	Arginine	264-274	solute carrier family 7 member 2	Homo sapiens	62-66
33109615-8	2020	Among the G12/13 pathway alterations were mutations in Arg-200 of Galpha13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-depedent (SRE.L) transcriptional activity.	Arginine	55-58	Yes1 associated transcriptional regulator	Homo sapiens	106-109
33109615-8	2020	Among the G12/13 pathway alterations were mutations in Arg-200 of Galpha13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-depedent (SRE.L) transcriptional activity.	Arginine	55-58	myocardin related transcription factor A	Homo sapiens	135-143
33222863-18	2020	In addition, the AA responsible for the bulk of mTORC1 activation in MAC-T are limited to Leu, Met, Ile, Arg, and Thr.	Arginine	105-108	CREB regulated transcription coactivator 1	Mus musculus	48-54
33051382-5	2020	Following the suppression of ASS1 protein levels, miR-1291 perturbed arginine homeostasis and preferably sensitized ASS1-abundant L3.3 cells to arginine deprivation therapy.	Arginine	69-77	microRNA 129-1	Homo sapiens	50-58
33051382-5	2020	Following the suppression of ASS1 protein levels, miR-1291 perturbed arginine homeostasis and preferably sensitized ASS1-abundant L3.3 cells to arginine deprivation therapy.	Arginine	144-152	microRNA 129-1	Homo sapiens	50-58
32544245-7	2020	At the high PCB dose, NADP and arginine appear to interact with drug-metabolizing enzymes (i.e. Cyp1-3 family), which are highly correlated with Ruminiclostridium and Roseburia, providing a novel explanation of gut-liver interaction from PCB-exposure.	Arginine	31-39	pyruvate carboxylase	Mus musculus	12-15
32544245-7	2020	At the high PCB dose, NADP and arginine appear to interact with drug-metabolizing enzymes (i.e. Cyp1-3 family), which are highly correlated with Ruminiclostridium and Roseburia, providing a novel explanation of gut-liver interaction from PCB-exposure.	Arginine	31-39	pyruvate carboxylase	Mus musculus	238-241
33051382-8	2020	Our results demonstrated that miR-1291 was effective to sensitize PC cells to arginine deprivation treatment and chemotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glycolysis, respectively, which may provide insights into understanding miRNA signaling underlying cancer cell metabolism and development of new strategies for the treatment of lethal PC.	Arginine	78-86	microRNA 129-1	Homo sapiens	30-38
33051382-11	2020	Consequently, miR-1291 was effective to enhance the efficacy of arginine deprivation (PEG-ADI) and chemotherapy (cisplatin), offering new insights into development of rational combination therapies.	Arginine	64-72	microRNA 129-1	Homo sapiens	14-22
33248609-5	2020	Dietary Arg level had a linear (P < 0.05) or quadratic (P < 0.05) effect on the gene expression of glutathione peroxidase 1, heme oxygenase 1, nuclear factor erythroid 2-related factor 2, and the activities of glutathione peroxidase and total antioxidative capacity in the jejunum and ileum.	Arginine	8-11	heme oxygenase 1	Gallus gallus	125-141
32920160-5	2020	Arginase I (ARG1) can process L-arginine in the local microenvironment and ultimately affect the function of T cells, resulting in immune escape.	Arginine	30-40	arginase 1	Homo sapiens	12-16
32974215-5	2020	SseK3 modified arginines at positions 74, 82, and 111 within Rab1 and this modification occurred independently of Rab1 nucleotide binding.	Arginine	15-24	RAB1A, member RAS oncogene family	Homo sapiens	61-65
32811353-7	2021	Substitution of arginines, which keep the ETGE motif attached, decreases the work needed for its release and increases DPP III  Kelch binding affinity.	Arginine	16-25	dipeptidyl peptidase 3	Homo sapiens	119-126
32910646-5	2020	This new binding mode enabled efficient exploration of the vector directed at the Arg-108 residue, leading to the identification of highly potent 3-azabicyclo[3.1.0]hexane acetic acid-based KHK inhibitors by combined use of parallel medicinal chemistry and structure-based drug design.	Arginine	82-85	ketohexokinase	Homo sapiens	190-193
32799865-4	2020	The discovery of Rag GTPases has greatly expanded our understanding of the regulation of mTORC1 activity by amino acids, especially leucine and arginine.	Arginine	144-152	CREB regulated transcription coactivator 1	Mus musculus	89-95
32278655-5	2020	RESULTS: The acute GLP-1 response to olive oil or arginine administration was markedly diminished in GcgGut-/- but preserved in GcgDistalGut-/- mice.	Arginine	50-58	glucagon	Mus musculus	19-24
33343341-10	2020	Additionally, wortmannin and Akt inhibitor VIII blocked the protective effect of gastrin on viability of HK-2 cells subjected to H/R treatment.	Arginine	131-132	cytochrome c oxidase subunit 8A	Homo sapiens	43-47
32597768-10	2020	Using the gene panel, a homozygous missense variant of FARS2 was identified, at Chr6 (GRCh37):g.5404829C>T, c.667C>T (NM_001318872.1), inherited from both parents, leading to an arginine-to-cysteine substitution, p.(Arg223Cys).	Arginine	178-186	phenylalanyl-tRNA synthetase 2, mitochondrial	Homo sapiens	55-60
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	SCY1 like pseudokinase 1	Homo sapiens	139-144
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	SCY1 like pseudokinase 1	Homo sapiens	139-144
32583741-7	2020	Knockdown of SCYL1 by small interfering RNA (siRNA) inhibited axon outgrowth, and the inhibitory effect was rescued by siRNA-resistant SCYL1, but not SCYL1 mutant, in which the arginine methylation site was replaced.	Arginine	177-185	SCY1 like pseudokinase 1	Homo sapiens	13-18
32583741-7	2020	Knockdown of SCYL1 by small interfering RNA (siRNA) inhibited axon outgrowth, and the inhibitory effect was rescued by siRNA-resistant SCYL1, but not SCYL1 mutant, in which the arginine methylation site was replaced.	Arginine	177-185	SCY1 like pseudokinase 1	Homo sapiens	135-140
32583741-7	2020	Knockdown of SCYL1 by small interfering RNA (siRNA) inhibited axon outgrowth, and the inhibitory effect was rescued by siRNA-resistant SCYL1, but not SCYL1 mutant, in which the arginine methylation site was replaced.	Arginine	177-185	SCY1 like pseudokinase 1	Homo sapiens	135-140
32583741-8	2020	Thus, PRMT1 regulates Golgi morphogenesis via SCYL1 arginine methylation.	Arginine	52-60	SCY1 like pseudokinase 1	Homo sapiens	46-51
32583741-9	2020	We propose that SCYL1 arginine methylation by PRMT1 contributes to axon and dendrite morphogenesis in neurons.	Arginine	22-30	SCY1 like pseudokinase 1	Homo sapiens	16-21
32165314-3	2020	The aim of this study was to determine the contribution of KCa channels in both insulin-induced l-arginine transport and NO synthesis, and its relationship with placental vascular relaxation.	Arginine	96-106	casein kappa	Homo sapiens	59-62
33204684-11	2020	It was found that induction of caspase-3 eliminated the protective effect of ginkgetin on H9C2 cells exposed to H/R.	Arginine	114-115	caspase 3	Rattus norvegicus	31-40
32427860-0	2020	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	Arginine	74-82	DALR anticodon binding domain containing 3	Homo sapiens	0-6
32427860-2	2020	However, the mechanism by which METTL2 identifies specific tRNA arginine species for m3C formation as well as the biological role of m3C in mammals is unknown.	Arginine	64-72	methyltransferase 2B, methylcytidine	Homo sapiens	32-38
32783662-6	2020	CONCLUSIONS: L-arginine-induced acute pancreatitis modulates TNF-alpha-AMPK axis, IL-10 and other AP biomarkers, which is protected by vitamin E; thus, may offer therapeutic potential in humans.	Arginine	13-23	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
32427860-3	2020	Here, we show that human METTL2 forms a complex with DALR anticodon binding domain containing 3 (DALRD3) protein to recognize particular arginine tRNAs destined for m3C modification.	Arginine	137-145	methyltransferase 2B, methylcytidine	Homo sapiens	25-31
32800549-0	2020	The yeast alpha-arrestin Art3 is a key regulator for arginine-induced endocytosis of the high-affinity proline transporter Put4.	Arginine	53-61	proline permease PUT4	Saccharomyces cerevisiae S288C	123-127
32427860-3	2020	Here, we show that human METTL2 forms a complex with DALR anticodon binding domain containing 3 (DALRD3) protein to recognize particular arginine tRNAs destined for m3C modification.	Arginine	137-145	DALR anticodon binding domain containing 3	Homo sapiens	97-103
32427860-4	2020	DALRD3-deficient human cells exhibit nearly complete loss of the m3C modification in tRNA-Arg species.	Arginine	90-93	DALR anticodon binding domain containing 3	Homo sapiens	0-6
32427860-6	2020	These findings uncover an unexpected function for the DALRD3 protein in the targeting of distinct arginine tRNAs for m3C modification and suggest a crucial biological role for DALRD3-dependent tRNA modification in proper neurological development.	Arginine	98-106	DALR anticodon binding domain containing 3	Homo sapiens	54-60
32849216-8	2020	After the patient was clinically diagnosed with IBMPFD, DNA analysis of the VCP gene revealed a cytosine (C) to thymine (T) (C  T) mutation, resulting in an amino acid exchange of arginine to cysteine (p.R155C mutation).	Arginine	180-188	valosin containing protein	Homo sapiens	76-79
32360667-2	2020	We have previously shown that globally inhibiting protein synthesis mobilizes intracellular L-arginine "pools" in retinal neurons, which concomitantly enhances neuronal nitric oxide synthase-mediated nitric oxide production.	Arginine	92-102	nitric oxide synthase 1, neuronal	Mus musculus	160-190
32800549-3	2020	Our previous study showed that arginine inhibits proline utilization by specifically inducing the endocytosis of the high-affinity proline transporter Put4.	Arginine	31-39	proline permease PUT4	Saccharomyces cerevisiae S288C	151-155
32800549-6	2020	First, we found that the ubiquitination activity of Rsp5 was essential for the arginine-induced endocytosis of Put4.	Arginine	79-87	proline permease PUT4	Saccharomyces cerevisiae S288C	111-115
32800549-7	2020	Because Put4 contains no Rsp5-binding motif, we next screened an adaptor protein that plays a role in the arginine-induced endocytosis of Put4.	Arginine	106-114	proline permease PUT4	Saccharomyces cerevisiae S288C	8-12
32252465-5	2020	Mutations of AhR residues within the Arg-Cys-rich region (R212A, R217A, R219A) and Asp371 (D371A) impaired AhR transformation without a significant effect on ligand binding.	Arginine	37-40	aryl hydrocarbon receptor	Homo sapiens	13-16
32800549-7	2020	Because Put4 contains no Rsp5-binding motif, we next screened an adaptor protein that plays a role in the arginine-induced endocytosis of Put4.	Arginine	106-114	proline permease PUT4	Saccharomyces cerevisiae S288C	138-142
32252465-5	2020	Mutations of AhR residues within the Arg-Cys-rich region (R212A, R217A, R219A) and Asp371 (D371A) impaired AhR transformation without a significant effect on ligand binding.	Arginine	37-40	aryl hydrocarbon receptor	Homo sapiens	107-110
32412630-7	2020	Arg supplementation decreased (P < 0.05) the protein abundance of apoptosis antigen 1 (FAS) (52.0% and 43.9%) but increased (P < 0.05) those of nuclear respiratory factor 1 (31.3% and 22.9%) and inducible NO synthase (35.2% and 41.8%) relative to the CON and CON + NAME groups, respectively.	Arginine	0-3	nuclear respiratory factor 1	Homo sapiens	144-172
33154747-3	2020	Examination of these SNPs led to the functional testing of rs1131769, a non-synonymous SNP in TMEM173 causing an Arg-to-His change at position 232 in the STING protein-a major regulator of innate immune responses to viral infections.	Arginine	113-116	stimulator of interferon response cGAMP interactor 1	Homo sapiens	94-101
32616523-9	2020	Mutational analysis of all residues of the (extracellular) helical cap of THIK-1 showed that mutation of the arginine residue at position 92, which is in the linker between cap helix 2 and pore helix 1, markedly reduced the inhibitory effect of IBMX.	Arginine	109-117	potassium channel, two pore domain subfamily K, member 13 S homeolog	Xenopus laevis	74-80
32540970-4	2020	We find that the arginine residue in the FLVR motif does not directly contact pTyr-1087 of a bound phosphopeptide derived from p190RhoGAP; rather, it makes an intramolecular salt bridge to an aspartic acid.	Arginine	17-25	Rho GTPase activating protein 35	Homo sapiens	127-137
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	35-43	Vba2p	Saccharomyces cerevisiae S288C	77-81
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	35-43	Vba2p	Saccharomyces cerevisiae S288C	210-214
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	Vba2p	Saccharomyces cerevisiae S288C	77-81
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	Vba2p	Saccharomyces cerevisiae S288C	210-214
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	Vba2p	Saccharomyces cerevisiae S288C	77-81
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	Vba2p	Saccharomyces cerevisiae S288C	210-214
32426941-2	2020	MDSCs express arginase-I and indoleamine 2,3-dioxygenase; they suppress T-cell function by reducing the levels of L-arginine and L-tryptophan, respectively.	Arginine	114-124	arginase, liver	Mus musculus	14-24
32474770-6	2020	However, the mRNA levels of two liver-enriched transcription factors (CEBPB and HNF1A), which are involved in regulating albumin expression, were significantly higher in cells grown in medium-containing arginine than that in cells grown in ornithine-containing medium.	Arginine	203-211	CCAAT enhancer binding protein beta	Homo sapiens	70-75
32474770-9	2020	When ornithine and arginine were depleted, albumin production was significantly reduced at the mRNA level, CEBPB mRNA levels were increased, and the level of activating form of C/EBPbeta was increased.	Arginine	19-27	CCAAT enhancer binding protein beta	Homo sapiens	107-112
32251994-2	2020	To achieve this, molecular dynamics (MD) simulation of RNase A and alpha-lactalbumin was performed in the presence of three charged amino acids Arg, Lys, and Asp and the molecular mechanism of amino acid-induced (de)stabilization of the proteins was examined by combining with our earlier report on Glu.	Arginine	144-147	ribonuclease A family member 1, pancreatic	Homo sapiens	55-62
32312763-0	2020	Differential Regulation of l-Arginine Metabolism through Arginase 1 during Infection with Leishmania mexicana Isolates Obtained from Patients with Localized and Diffuse Cutaneous Leishmaniasis.	Arginine	27-37	arginase 1	Homo sapiens	57-67
32312763-1	2020	l-Arginine metabolism through arginase 1 (Arg-1) and inducible nitric oxide synthase (NOS2) constitutes a fundamental axis for the resolution or progression of leishmaniasis.	Arginine	0-10	arginase 1	Homo sapiens	30-40
32312763-1	2020	l-Arginine metabolism through arginase 1 (Arg-1) and inducible nitric oxide synthase (NOS2) constitutes a fundamental axis for the resolution or progression of leishmaniasis.	Arginine	0-10	arginase 1	Homo sapiens	42-47
32312763-3	2020	In this work, we analyzed in an in vivo model the capacity of two L. mexicana isolates, one obtained from a patient with LCL and the other from a patient with DCL, to regulate the metabolism of l-arginine through Arg-1 and NOS2.	Arginine	194-204	arginase 1	Homo sapiens	213-218
32312763-9	2020	Our results suggest that L. mexicana isolates obtained from patients with LCL or DCL exhibit different virulence or pathogenicity degrees and differentially regulate l-arginine metabolism through Arg-1.	Arginine	166-176	arginase 1	Homo sapiens	196-201
32350111-7	2020	We demonstrate that unique BMP15 finger residues at this site (Arg-301, Gly-304, His-307, and Met-369) enable potent activation of the SMAD2/3 pathway.	Arginine	63-66	SMAD family member 2	Homo sapiens	135-142
32456215-2	2020	Importantly, our previous work demonstrated that PRMT5 overexpression could substantially augment activation of the nuclear factor kappa B (NF-kappaB) via methylation of arginine 30 (R30) on its p65 subunit, while knockdown of PRMT5 showed the opposite effect.	Arginine	170-178	RELA proto-oncogene, NF-kB subunit	Homo sapiens	195-198
32362314-2	2020	The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site containing multiple arginine residues (multibasic) not found in closely related animal coronaviruses.	Arginine	120-128	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	10-15
31081586-3	2020	Here we show that Arabidopsis thaliana (Arabidopsis) arginine decarboxylase 1 (ADC1), one of the two known arginine decarboxylases in Arabidopsis, not only synthesizes agmatine from arginine, but also converts Ndelta -acetylornithine to N-acetylputrescine.	Arginine	53-61	arginine decarboxylase 1	Arabidopsis thaliana	79-83
32014252-4	2020	Two new blaNDM-1 alleles that have polymorphisms in the signal peptide; NDM-1(P9R), a proline to arginine substitution, and NDM-2, a proline to alanine substitution (P28A) were studied.	Arginine	97-105	NDM-1 metallo-beta-lactamase	Escherichia coli	8-16
32283586-5	2020	We have earlier shown that KSHV ORF59, viral processivity factor, binds to a protein arginine methyl transferase 5 (PRMT5) to alter the histone arginine methylation during reactivation.	Arginine	85-93	ORF59	Human gammaherpesvirus 8	32-37
31241013-7	2020	Finally, USP8 inhibited SQSTM1 degradation and autophagic influx in cells with wild-type SQSTM1, but not its mutant with substitution of K420 with an arginine.	Arginine	150-158	ubiquitin specific peptidase 8	Mus musculus	9-13
31769566-0	2020	Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy.	Arginine	10-18	actin gamma 2, smooth muscle	Homo sapiens	40-45
31769566-8	2020	Within the ACTG2-positive group, poor outcomes (characterized by total parenteral nutrition dependence, death, or transplantation) were invariably due to one of the arginine missense alleles.	Arginine	165-173	actin gamma 2, smooth muscle	Homo sapiens	11-16
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Arginine	110-120	interleukin 4 induced 1	Homo sapiens	4-45
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Arginine	110-120	interleukin 4 induced 1	Homo sapiens	47-50
31913350-9	2020	Interestingly, in ND mice, SF-PreCon significantly reduced MI/R-induced activation of p38, a pro-death MAPK, without altering ERK and JNK.	Arginine	62-63	mitogen-activated protein kinase 14	Mus musculus	86-89
31709652-7	2020	L-arginine also suppressed the expression of inflammation-related genes and the protein expression of cleaved caspase-3, whereas it upregulated the mRNA and protein expression of tight junction proteins and LC3B protein expression.	Arginine	0-10	caspase 3	Rattus norvegicus	110-119
31709652-8	2020	In vitro, L-arginine attenuated HS-induced apoptosis as demonstrated by flow cytometry and decreased cleaved caspase-3 protein expression.	Arginine	10-20	caspase 3	Rattus norvegicus	109-118
31861708-3	2019	Accumulating evidence suggests that serine-arginine protein kinase 1 (SRPK1), an enzyme that phosphorylates splicing factors rich in serine/arginine domains, has a prognostic and potential predictive role in various cancers.	Arginine	43-51	SRSF protein kinase 1	Homo sapiens	70-75
32306102-9	2020	The conservation of plant ACRs is reminiscent of that of human cellular arginine sensor for mTORC1 (CASTOR1), a member of a small protein family highly conserved in animals.	Arginine	72-80	CREB regulated transcription coactivator 1	Mus musculus	92-98
32169720-6	2020	l-Arginine also reduces the over-expression of inflammatory molecules induced by LPS (TNF-alpha, IL-6 and IL-1beta, p < 0.001).	Arginine	0-10	interferon beta-2	Bos taurus	97-101
32169720-6	2020	l-Arginine also reduces the over-expression of inflammatory molecules induced by LPS (TNF-alpha, IL-6 and IL-1beta, p < 0.001).	Arginine	0-10	interleukin 1 alpha	Bos taurus	106-114
32169720-9	2020	The RT-PCR analysis confirmed the modifications of Fibrillin-1, ADAMTSL4, Basigin and Xanthine Oxidase, whose expression levels increase after stimulation with LPS and are reduced by l-Arginine (p < 0.05).	Arginine	183-193	ADAMTS like 4	Bos taurus	64-72
31469916-4	2020	We found PRMT6 to methylate CRAF at arginine 100, interfere with its RAS/RAF binding potential and as a result alter ERK-mediated PKM2 translocation into the nucleus.	Arginine	36-44	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	28-32
31469916-4	2020	We found PRMT6 to methylate CRAF at arginine 100, interfere with its RAS/RAF binding potential and as a result alter ERK-mediated PKM2 translocation into the nucleus.	Arginine	36-44	zinc fingers and homeoboxes 2	Homo sapiens	29-32
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	nuclear respiratory factor 1	Homo sapiens	187-215
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	nuclear respiratory factor 1	Homo sapiens	217-221
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	transcription factor B1, mitochondrial	Homo sapiens	262-267
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	ATP synthase membrane subunit c locus 1	Homo sapiens	304-309
32019866-3	2020	Leucine, arginine, and methionine signal to mTORC1 through the well-characterized Rag GTPase signaling pathway.	Arginine	9-17	CREB regulated transcription coactivator 1	Mus musculus	44-50
32181366-5	2020	In contrast, two related SAK1 toxins, Hui1 and ShK, block KcsA and Kv1.3, respectively, via an arginine rather than the canonical lysine, when tethered and as free peptides.	Arginine	95-103	potassium voltage-gated channel subfamily A member 3	Homo sapiens	67-72
31940832-5	2020	Several studies have reported beneficial effects after nut consumption on glucose control, appetite suppression, metabolites related to adipose tissue and gut microbiota, and on adipokines due to their fatty acid profile, vegetable proteins, l-arginine, dietary fibers, vitamins, minerals, and phytosterols.	Arginine	242-252	NUT midline carcinoma family member 1	Homo sapiens	55-58
31114027-0	2020	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	Arginine	7-15	ubiquitin associated protein 2 like	Homo sapiens	0-6
31709652-9	2020	L-arginine induced autophagy, which was demonstrated by decreased expression of p62 and p-mTOR/mTOR, and increased expression of LC3B.	Arginine	0-10	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	80-83
32581465-7	2020	The SC dimensions were reduced in the untraumatized fellow eyes of ARG patients when compared with the normal eyes (SC-SCA: 2350 +- 602.1 mum2, p = 0.001, meridional diameter: 341.8 +- 88.8 mum, p = 0.012 and coronal diameter: 31.67 +- 3.8 mum, p < 0.0001).	Arginine	67-70	trafficking protein particle complex subunit 1	Homo sapiens	138-142
31541192-3	2020	Somatic heterozygous missense mutations in PPP2R1A, the gene encoding the PP2A Aalpha scaffolding subunit, have been identified across multiple cancer types, but the effects of the most commonly mutated residue, Arg-183, on PP2A function have yet to be fully elucidated.	Arginine	212-215	protein phosphatase 2 scaffold subunit Aalpha	Homo sapiens	43-50
32454488-9	2020	Arg-II knockout enhances Arg-I expression and activity, but inhibits interleukin (IL)-6 expression and secretion and reduces active p38mapk in aging adipose tissue macrophages and stromal cells.	Arginine	0-3	mitogen-activated protein kinase 14	Mus musculus	132-139
33148838-5	2020	RESULTS: Results: It has been established that individuals with mutant genotypes Arg/Gln of TLR-2, Leu/Phe, Phe/Phe of TLR-3, Asp/Gly of TLR-4 genes have a vaccinal response to administering anti-influenza vaccine at the level of subjects with normal distribution of TLR alleles, as evidenced by the growth in dynamics of mean geometric titers of antibodies to vaccine strains, the level of seroprotection and seroconversion.	Arginine	81-84	toll like receptor 3	Homo sapiens	119-124
30853601-8	2019	In turn, alterations of y+LAT2-mediated Gln/Arg exchange and Arg uptake in astrocyte, modulate astrocytic nitric oxide synthesis and oxidative/nitrosative stress in ammonia-overexposed brain.	Arginine	44-47	linker for activation of T cells family member 2	Homo sapiens	26-30
30853601-8	2019	In turn, alterations of y+LAT2-mediated Gln/Arg exchange and Arg uptake in astrocyte, modulate astrocytic nitric oxide synthesis and oxidative/nitrosative stress in ammonia-overexposed brain.	Arginine	61-64	linker for activation of T cells family member 2	Homo sapiens	26-30
32647818-1	2020	Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea.	Arginine	83-93	arginase 1	Homo sapiens	0-10
31690955-1	2019	L-arginine depletion by regulatory cells and cancer cells expressing arginase-1 (Arg-1) is a vital contributor to the immunosuppressive tumor microenvironment in patients with cancer.	Arginine	0-10	arginase 1	Homo sapiens	69-79
31690955-1	2019	L-arginine depletion by regulatory cells and cancer cells expressing arginase-1 (Arg-1) is a vital contributor to the immunosuppressive tumor microenvironment in patients with cancer.	Arginine	0-10	arginase 1	Homo sapiens	81-86
31661001-14	2019	In addition, flow cytometry on fresh B16-hCXCR4 tumors showed significantly higher Tregs number following anti-PD-1 partially reversed by the combined treatment Pep R and anti-PD-1.	Arginine	45-46	prolyl endopeptidase	Mus musculus	161-164
31473880-9	2019	Ectopic expression of non-methylatable hnRNP A1 mutants demonstrated that methylation of either arginine residues 218 or 225 was sufficient to maintain IRES binding and hnRNP A1-dependent cyclin D1 or c-MYC IRES activity, however a double R218K/R225K mutant was unable to do so.	Arginine	96-104	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	169-177
31473880-9	2019	Ectopic expression of non-methylatable hnRNP A1 mutants demonstrated that methylation of either arginine residues 218 or 225 was sufficient to maintain IRES binding and hnRNP A1-dependent cyclin D1 or c-MYC IRES activity, however a double R218K/R225K mutant was unable to do so.	Arginine	96-104	cyclin D1	Homo sapiens	188-197
31616317-2	2019	Recently, it was shown that L-arginine administration prevented the decrease in levels of the muscle cytoskeletal proteins, desmin and dystrophin, in rat soleus muscle after 14 days of hindlimb unloading.	Arginine	28-38	desmin	Rattus norvegicus	124-130
31175853-6	2019	Thus, the present study was undertaken to detect the effects of FGF-21 on l-arginine induced chronic pancreatitis/islet fibrosis in mice.	Arginine	74-84	fibroblast growth factor 21	Mus musculus	64-70
31668641-3	2019	mTORC1 activation was induced by amino acids, especially arginine and leucine, accompanied by the dynamic lysosomal localization of the mTOR and Tsc complexes.	Arginine	57-65	CREB regulated transcription coactivator 1	Mus musculus	0-6
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Arginine	12-20	potassium voltage-gated channel subfamily E regulatory subunit 2	Homo sapiens	72-77
31679457-6	2019	Here, we describe an arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2 in HEK293 cells.	Arginine	21-29	potassium voltage-gated channel subfamily E regulatory subunit 2	Homo sapiens	159-164
30954759-2	2019	In NADP+-bound and biliverdin-bound BVR-A, two biliverdins are stacked at the binding cleft; one is positioned to accept hydride from NADPH, and the other appears to donate a proton to the first biliverdin through a neighboring arginine residue.	Arginine	228-236	biliverdin reductase A	Homo sapiens	36-41
33154747-3	2020	Examination of these SNPs led to the functional testing of rs1131769, a non-synonymous SNP in TMEM173 causing an Arg-to-His change at position 232 in the STING protein-a major regulator of innate immune responses to viral infections.	Arginine	113-116	stimulator of interferon response cGAMP interactor 1	Homo sapiens	154-159
31368041-5	2019	The critical residues implicated in the substrate binding of Arabidopsis thaliana CBL (Tyr-127, Arg-129, Tyr-181, and Arg-440) were highly conserved in both Mp mimosinase and CBL.	Arginine	96-99	cystathionine beta-lyase	Arabidopsis thaliana	82-85
33037310-5	2020	We show that a crucial third arginine at the left middle position, comprising a motif RRxR is required for furin recognition in vitro, while the general motif RxxR in common with MERS-CoV is not sufficient for cleavage.	Arginine	29-37	furin, paired basic amino acid cleaving enzyme	Homo sapiens	107-112
31368041-5	2019	The critical residues implicated in the substrate binding of Arabidopsis thaliana CBL (Tyr-127, Arg-129, Tyr-181, and Arg-440) were highly conserved in both Mp mimosinase and CBL.	Arginine	96-99	cystathionine beta-lyase	Arabidopsis thaliana	175-178
31368041-5	2019	The critical residues implicated in the substrate binding of Arabidopsis thaliana CBL (Tyr-127, Arg-129, Tyr-181, and Arg-440) were highly conserved in both Mp mimosinase and CBL.	Arginine	118-121	cystathionine beta-lyase	Arabidopsis thaliana	82-85
31368041-5	2019	The critical residues implicated in the substrate binding of Arabidopsis thaliana CBL (Tyr-127, Arg-129, Tyr-181, and Arg-440) were highly conserved in both Mp mimosinase and CBL.	Arginine	118-121	cystathionine beta-lyase	Arabidopsis thaliana	175-178
31309634-7	2019	Distinct from other identified CBG-binding sequences, an arginine residue flanking the KXL motif of ORC1 inserts into a neighboring acidic pocket, contributing to the strong ORC1-Cyclin A association.	Arginine	57-65	origin recognition complex subunit 1	Homo sapiens	100-104
31309634-7	2019	Distinct from other identified CBG-binding sequences, an arginine residue flanking the KXL motif of ORC1 inserts into a neighboring acidic pocket, contributing to the strong ORC1-Cyclin A association.	Arginine	57-65	origin recognition complex subunit 1	Homo sapiens	174-178
31495062-0	2019	Arginine methylation augments Sbp1 function in translation repression and decapping.	Arginine	0-8	multiple EGF like domains 8	Homo sapiens	30-34
31495062-4	2019	Sbp1 is known to be methylated on arginine residues in RGG-motif; however, the functional relevance of this modification in vivo remains unknown.	Arginine	34-42	multiple EGF like domains 8	Homo sapiens	0-4
31495062-5	2019	Here, we report that Sbp1 is arginine-methylated in an Hmt1-dependent manner and that methylation is enhanced upon glucose deprivation.	Arginine	29-37	multiple EGF like domains 8	Homo sapiens	21-25
31495062-6	2019	Characterization of an arginine-methylation-defective (AMD) mutant provided evidence that methylation affects Sbp1 function in vivo.	Arginine	23-31	multiple EGF like domains 8	Homo sapiens	110-114
31495062-11	2019	Taken together, these results suggest that arginine methylation modulates Sbp1 role in mRNA fate determination.	Arginine	43-51	multiple EGF like domains 8	Homo sapiens	74-78
32011309-6	2019	It was found out that in the samples of the cerebral hemispheres, the content of MBP (18.4 kDa) increased in 4.8 times (p<0.001) with the use of L-arginine, in 10 times (p<0.001) - with aminoguanidine, in 13 times (p<0.001) - in cases of the combined use of L-arginine and aminoguanidine compare to the indices of the mice with antiphospholipid syndrome.	Arginine	145-155	myelin basic protein	Mus musculus	81-84
32011309-6	2019	It was found out that in the samples of the cerebral hemispheres, the content of MBP (18.4 kDa) increased in 4.8 times (p<0.001) with the use of L-arginine, in 10 times (p<0.001) - with aminoguanidine, in 13 times (p<0.001) - in cases of the combined use of L-arginine and aminoguanidine compare to the indices of the mice with antiphospholipid syndrome.	Arginine	258-268	myelin basic protein	Mus musculus	81-84
32658257-3	2020	We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.	Arginine	36-44	Fc gamma receptor IIa	Homo sapiens	30-35
31032902-7	2019	Mechanistically, TGFbeta-induced Snail1 promotes the epigenetic mark of asymmetrically dimethylated arginine.	Arginine	100-108	transforming growth factor alpha	Homo sapiens	17-24
31399282-2	2019	Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respectively.	Arginine	4-14	arginase 1	Homo sapiens	43-53
32658257-3	2020	We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.	Arginine	36-44	Fc gamma receptor IIa	Homo sapiens	30-34
32658257-3	2020	We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.	Arginine	46-48	Fc gamma receptor IIa	Homo sapiens	30-35
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Arginine	96-99	S100 calcium binding protein A8	Homo sapiens	203-207
32658257-3	2020	We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions.	Arginine	46-48	Fc gamma receptor IIa	Homo sapiens	30-34
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Arginine	100-103	S100 calcium binding protein A8	Homo sapiens	203-207
32087070-9	2019	The significant difference in genotype distribution was observed in recessive model (Pro/Pro vs Arg/Arg + Arg/Pro) when stratifying by H. pylori infection (OR = 2.02, 95% CI 1.03-3.96, p = 0.041) and by cagA-positivity (OR = 2.33, 95% CI 1.07-5.07, p = 0.032).	Arginine	100-103	S100 calcium binding protein A8	Homo sapiens	203-207
31378783-5	2019	PRMT3 activated the expression of miR-3648 by enhancing histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) levels at promoter region of the gene.	Arginine	67-75	microRNA 3648-1	Homo sapiens	34-42
32679368-0	2020	Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage.	Arginine	0-8	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	24-28
31152925-0	2019	Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo.	Arginine	105-113	phenylalanine hydroxylase	Homo sapiens	154-156
31152925-2	2019	To overcome the toxic side effects and multidrug resistance (MDR) during doxorubicin (DOX) chemotherapy, an arginine-glycine-aspartic (RGD) tripeptide modified, pH-sensitive solid lipid nanoparticles (SLNs) is employed in this study.	Arginine	108-116	phenylalanine hydroxylase	Homo sapiens	161-163
31885778-3	2019	Protein arginine methylation transferase 5 (PRMT5), which mediates arginine methylation involved in the regulation of epigenetics, exhibits a variety of biological functions and essential roles in diseases.	Arginine	8-16	protein arginine N-methyltransferase 5	Mus musculus	44-49
32679368-4	2020	Here, we report arginine methylation as a post-translational modification (PTM) that regulates APE1 translocation to mitochondria in HeLa and HEK-293 cells.	Arginine	16-24	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	95-99
32679368-13	2020	This work describes a novel PTM regulation model of APE1 subcellular distribution through arginine methylation.	Arginine	90-98	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	52-56
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Arginine	86-94	ornithine decarboxylase 1	Homo sapiens	33-37
31743939-8	2019	The exome sequencing revealed a novel homozygous variant (c.296G>T) in ARL3, which is predicted to substitute an evolutionarily conserved arginine with isoleucine within the encoded protein GTP-binding domain (R99I).	Arginine	138-146	ADP ribosylation factor like GTPase 3	Homo sapiens	71-75
32597240-6	2020	DNA sequencing confirmed the occurrence of a new heterozygous mutation [HBA1:C.182A G] at codon 60, resulting in a coding change from lysine to arginine.	Arginine	144-152	hemoglobin subunit alpha 1	Homo sapiens	72-76
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Arginine	86-94	spermine oxidase	Homo sapiens	55-59
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Arginine	86-94	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	65-69
31479430-4	2019	To overcome this limitation, we test an arginine-rich Pip6a cell-penetrating peptide and show that Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced ASO delivery into striated muscles of DM1 mice following systemic administration in comparison with unconjugated PMO and other ASO strategies.	Arginine	40-48	prolactin induced protein	Mus musculus	54-57
32991636-5	2020	Molecular docking simulations confirmed enhanced binding of heparan sulphate to a model of the adapted SAT1 virus, with the region around VP1 arginine 112 contributing the most to binding.	Arginine	142-150	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	103-107
31199872-6	2019	The ESs disrupt the Rev-binding site by changing local secondary structure, and their stabilization via point substitution mutations decreases the binding affinity to the Rev arginine-rich motif (ARM) by 15- to 80-fold.	Arginine	175-183	Rev	Human immunodeficiency virus 1	20-23
31199872-6	2019	The ESs disrupt the Rev-binding site by changing local secondary structure, and their stabilization via point substitution mutations decreases the binding affinity to the Rev arginine-rich motif (ARM) by 15- to 80-fold.	Arginine	175-183	Rev	Human immunodeficiency virus 1	171-174
32995772-3	2020	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	neuropilin 1	Homo sapiens	140-145
32971830-8	2020	In conclusion, L-arginine, L-leucine, L-glutamine, and L-tryptophan, when administered to obese adolescents with a fixed-dose meal, are capable of evoking an anorexigenic response, which is, at least in part, mediated by an increase in GLP-1 released in circulation by L cells, which are capable of chemosensing specific amino acids present in the intestinal lumen.	Arginine	15-25	glucagon like peptide 1 receptor	Homo sapiens	236-241
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	10-18	CREB regulated transcription coactivator 1	Mus musculus	30-36
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	10-18	CREB regulated transcription coactivator 1	Mus musculus	129-135
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	142-150	CREB regulated transcription coactivator 1	Mus musculus	30-36
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	142-150	CREB regulated transcription coactivator 1	Mus musculus	129-135
32919119-6	2020	Cellular l-Arginine to medium NOHA ratio was higher, and by at least 6.5-22.5 fold in ER- breast tumor 3D-spheroids, and at least 10-70 fold in ER- ovarian tumor 3D spheroids, than in ER+ and control conditions; and was >=48% higher in ER- ovarian cancer than in ER- breast cancer 3D-spheroids.	Arginine	9-19	epiregulin	Homo sapiens	184-187
31101333-0	2019	Arginine induces IGF-1 secretion from the endoplasmic reticulum.	Arginine	0-8	insulin-like growth factor 1	Mus musculus	17-22
31101333-1	2019	Arginine is a semi-essential amino acid with multiple functions, including stimulating the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).	Arginine	0-8	insulin-like growth factor 1	Mus musculus	128-156
32557770-9	2020	We then observed that arginine induced the endocytosis of the proline transporters Put4 and Gap1, whereas ammonium induced the endocytosis of only Gap1.	Arginine	22-30	proline permease PUT4	Saccharomyces cerevisiae S288C	83-87
31101333-1	2019	Arginine is a semi-essential amino acid with multiple functions, including stimulating the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).	Arginine	0-8	insulin-like growth factor 1	Mus musculus	158-163
31101333-3	2019	Previous studies showed that arginine-induced IGF-1 secretion occurs via two pathways: a GH-dependent pathway and an arginine-dependent pathway with an unknown mechanism.	Arginine	29-37	insulin-like growth factor 1	Mus musculus	46-51
31101333-3	2019	Previous studies showed that arginine-induced IGF-1 secretion occurs via two pathways: a GH-dependent pathway and an arginine-dependent pathway with an unknown mechanism.	Arginine	117-125	insulin-like growth factor 1	Mus musculus	46-51
31101333-6	2019	As observed in fasted mice and hepatocytes cultivated in arginine-depleted medium, decreases in arginine concentrations resulted in IGF-1 retention in the endoplasmic reticulum.	Arginine	96-104	insulin-like growth factor 1	Mus musculus	132-137
31101333-7	2019	Arginine administration reverses this retention, leading to IGF-1 secretion.	Arginine	0-8	insulin-like growth factor 1	Mus musculus	60-65
31103260-7	2019	These results suggest that Hsp70/CHIP chaperone-mediated protein degradation system is crucial in the regulation of PRMT5-v2 turnover, which has the potential to balance the symmetrical arginine dimethylation in cells.	Arginine	186-194	protein arginine N-methyltransferase 5	Mus musculus	116-124
32872412-3	2020	The Arg-90 and Glu-98 from MotA interact with Asp-289 and Arg-281 of FliG, respectively.	Arginine	4-7	FRAS1 related extracellular matrix 1	Homo sapiens	27-31
32872412-3	2020	The Arg-90 and Glu-98 from MotA interact with Asp-289 and Arg-281 of FliG, respectively.	Arginine	58-61	FRAS1 related extracellular matrix 1	Homo sapiens	27-31
32844749-0	2020	Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	0-8	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	24-30
30541128-0	2019	The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.	Arginine	15-18	fibroblast growth factor receptor 4	Mus musculus	39-44
32844749-0	2020	Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	109-112
29737046-4	2019	The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs.	Arginine	92-95	CGRP receptor component	Homo sapiens	4-7
32839531-8	2020	Furthermore, the expression of mRNAs participating in arginine biosynthesis (CPS1, OTC, Arg1) and do novo purine synthesis (GART, PAICS, ATIC) were validated through RT-qPCR.	Arginine	54-62	carbamoyl-phosphate synthase 1	Homo sapiens	77-81
30981631-2	2019	The two enriched in arginine, poly(GR) and poly(PR), infiltrate liquid-like nucleoli, co-localize with the nucleolar protein nucleophosmin (NPM1), and alter the phase separation behavior of NPM1 in vitro.	Arginine	20-28	nucleophosmin 1	Homo sapiens	125-138
30981631-2	2019	The two enriched in arginine, poly(GR) and poly(PR), infiltrate liquid-like nucleoli, co-localize with the nucleolar protein nucleophosmin (NPM1), and alter the phase separation behavior of NPM1 in vitro.	Arginine	20-28	nucleophosmin 1	Homo sapiens	140-144
30981631-2	2019	The two enriched in arginine, poly(GR) and poly(PR), infiltrate liquid-like nucleoli, co-localize with the nucleolar protein nucleophosmin (NPM1), and alter the phase separation behavior of NPM1 in vitro.	Arginine	20-28	nucleophosmin 1	Homo sapiens	190-194
32839531-8	2020	Furthermore, the expression of mRNAs participating in arginine biosynthesis (CPS1, OTC, Arg1) and do novo purine synthesis (GART, PAICS, ATIC) were validated through RT-qPCR.	Arginine	54-62	arginase 1	Homo sapiens	88-92
32973838-5	2020	Here, we showed that the substitution of arginine with isoleucine in the FRNK motif at position 184 of helper component-proteinase (HC-Pro) abolished its RNA silencing suppression (RSS) activity, drastically reduced the virulence and accumulation level of SCMV, and impaired the synergism between SCMV and maize chlorotic mottle virus.	Arginine	41-49	protein tyrosine kinase 2	Homo sapiens	73-77
32817790-6	2020	These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis (sterol regulatory element-binding protein-1, acetyl-CoA carboxylase alpha, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid beta-oxidation (carnitine palmitoyltransferase 1alpha and peroxisome proliferator-activated receptor alpha).	Arginine	17-25	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	352-400
30916578-10	2019	Furthermore, l-arginine administration downregulated the liver expression of the apoptotic marker, caspase-3.	Arginine	13-23	caspase 3	Rattus norvegicus	99-108
30938419-5	2019	Here we report the inhibition of NMD by arginine-rich dipeptide repeats derived from C9orf72 hexanucleotide repeat expansion, the most common cause of familial amyotrophic lateral sclerosis.	Arginine	40-48	C9orf72-SMCR8 complex subunit	Homo sapiens	85-92
32692156-3	2020	UBR1 and UBR2 are sequelogous, functionally overlapping, and dominate the targeting of Arg/N-degron substrates in examined cell lines.	Arginine	87-90	ubiquitin protein ligase E3 component n-recognin 2	Homo sapiens	9-13
30938419-7	2019	Using Drosophila as a model, we have validated that the C9orf72 hexanucleotide repeat expansion products could lead to the accumulation of the NMD substrates and identified arginine-rich dipeptide repeats, including poly glycine-arginine and poly proline-arginine, as the main culprits of NMD inhibition.	Arginine	173-181	C9orf72-SMCR8 complex subunit	Homo sapiens	56-63
30938419-13	2019	Therefore, our study has revealed a cellular mechanism whereby arginine-rich C9orf72 dipeptide repeats could inhibit NMD activities by reducing the abundance of processing bodies.	Arginine	63-71	C9orf72-SMCR8 complex subunit	Homo sapiens	77-84
32692156-8	2020	We also show, through chase-degradation assays with [UBR1-/- UBR2-/-] and wild-type human cells, that the Arg/N-degron pathway mediates a large fraction of ATF3 degradation.	Arginine	106-109	ubiquitin protein ligase E3 component n-recognin 2	Homo sapiens	61-65
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Arginine	188-196	angiopoietin 1	Homo sapiens	66-80
32371920-1	2020	PURPOSE: The persistence of hypermutable CGN (CGG, CGA, CGC, CGU) arginine codons at high frequency suggests the possibility of negative selective pressure at these sites and that arginine codon usage could be a predictive indicator of human disease genes.	Arginine	66-74	cingulin	Homo sapiens	41-44
30770653-2	2019	In this study, a vascular endothelial growth factor (VEGF165) and angiopoietin-1 (Ang-1) dual gene coexpression vector that encoded green fluorescent protein (GFP) was constructed from an arginine-glycine-aspartic acid-modified adenovirus.	Arginine	188-196	angiopoietin 1	Homo sapiens	82-87
30770653-7	2019	In conclusion, SF scaffolds loaded with arginine-glycine-aspartic acid-modified adenovirus vectors encoding VEGF165 and Ang-1 could stimulate the formation of vascular networks through the effective expression of target genes in vascular endothelial cells, thereby accelerating the regeneration of dermal tissue.	Arginine	40-48	angiopoietin 1	Homo sapiens	120-125
30517687-3	2019	In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A alpha-tubulin selectively impair dynein motor activity and severely and dominantly disrupt cortical neuronal migration.	Arginine	64-72	tubulin alpha 1a	Homo sapiens	99-105
32371920-1	2020	PURPOSE: The persistence of hypermutable CGN (CGG, CGA, CGC, CGU) arginine codons at high frequency suggests the possibility of negative selective pressure at these sites and that arginine codon usage could be a predictive indicator of human disease genes.	Arginine	180-188	cingulin	Homo sapiens	41-44
32371920-3	2020	RESULTS: The frequency of CGN codons among a gene"s total arginine codon count was higher in genes linked to syndromic autism spectrum disorder (ASD) compared with genes not associated with ASD.	Arginine	58-66	cingulin	Homo sapiens	26-29
32371920-6	2020	CONCLUSION: Our findings indicate that genes utilizing CGN arginine codons rather than AGG or AGA are more likely to underlie single-gene disorders, particularly for dominant phenotypes, and thus constitute candidate genes for the study of human genetic disease.	Arginine	59-67	cingulin	Homo sapiens	55-58
32619111-1	2020	Hb Manitoba [alpha102(G9)Ser Arg] results from an AGC>CGC or AGC>AGA substitution at codon 102 of the HBA1 or HBA2 genes.	Arginine	29-32	hemoglobin subunit alpha 1	Homo sapiens	102-106
31024442-6	2019	Several neurochemicals have been reported to regulate GnRH neuronal activity, but recently two hypothalamic neuropeptides belonging to the superfamily of (Arg)(Phe)-amide peptides, RFRP-3 and kisspeptin, have emerged as critical for the integration of environmental cues within the reproductive axis.	Arginine	155-158	neuropeptide VF precursor	Homo sapiens	181-185
32619111-1	2020	Hb Manitoba [alpha102(G9)Ser Arg] results from an AGC>CGC or AGC>AGA substitution at codon 102 of the HBA1 or HBA2 genes.	Arginine	29-32	hemoglobin subunit alpha 2	Homo sapiens	110-114
32563156-3	2020	Mechanistic assays in breast cancer cells indicate that PRMT1 methylates PR at the arginine 637 and reduces the stability of the receptor, thereby accelerating its recycling and finally its transcriptional activity.	Arginine	83-91	progesterone receptor	Homo sapiens	56-58
30117412-11	2019	The angiopoietin2:angiopoietin1 mRNA ratio tended to increase (P=0.07) in ARG fed sows.	Arginine	74-77	angiopoietin 2	Homo sapiens	4-17
30117412-11	2019	The angiopoietin2:angiopoietin1 mRNA ratio tended to increase (P=0.07) in ARG fed sows.	Arginine	74-77	angiopoietin 1	Homo sapiens	18-31
32494070-5	2020	A proline-arginine-rich sequence within the LCD binds to microtubules and targets condensation of LEM2 to spindle microtubules that traverse the nascent nuclear envelope.	Arginine	10-18	LEM domain nuclear envelope protein 2	Homo sapiens	98-102
30738683-8	2019	In addition, the dry matter intake, apparent digestibility of N, and the concentration of milk protein N in the Nor-NOHA did not differ from the control; however, the infusion of nor-NOHA and Arg resulted in greater concentrations of high-density lipoprotein, IgA, IL-1beta, and tumor necrosis factor-alpha, and lower concentrations of cholesterol in serum compared with the control.	Arginine	192-195	interleukin 1 beta	Bos taurus	265-273
32339452-2	2020	Oxidation of the rhenium(III) terminal oxo ORe(eta2-DHF)(BDI) (DHF = dihydrofulvalene, BDI = N,N"-bis(2,6-diisopropylphenyl)-3,5-dimethyl-beta-diketiminate) with organic azides R-N3 (R = tBu, 2,6-diisopropylphenyl) yields the title complexes.	Arginine	44-45	DNA polymerase iota	Homo sapiens	47-51
30452708-10	2019	The 70% of Arg group showed higher FCR compared to 100% (P &lt; 0.0001) with quadratic effects (P &lt; 0.002, R2 &gt; 0.94) for all periods.	Arginine	11-14	FCR	Gallus gallus	35-38
30639019-0	2019	Enhanced supply of methionine or arginine alters mechanistic target of rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat-stressed bovine mammary epithelial cells in vitro.	Arginine	33-41	mechanistic target of rapamycin kinase	Bos taurus	49-80
30696923-6	2019	Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1), which catabolize Trp and Arg, respectively, respond to inflammatory cues including interferons and transforming growth factor-beta (TGFbeta) cytokines.	Arginine	82-85	arginase 1	Homo sapiens	38-48
30696923-6	2019	Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1), which catabolize Trp and Arg, respectively, respond to inflammatory cues including interferons and transforming growth factor-beta (TGFbeta) cytokines.	Arginine	82-85	arginase 1	Homo sapiens	50-54
31531954-4	2019	In this study, an affibody molecule against HER3 is conjugated to a biomimetic peptide RALA (an amphipathic and cationic peptide enriched with arginine) and the ability of the fusion vector for targeting HER3 and afterward delivering specific genes in breast cancer cells is evaluated.	Arginine	143-151	erb-b2 receptor tyrosine kinase 3	Homo sapiens	44-48
32321555-0	2020	Arginine is neuroprotective through suppressing HIF-1alpha/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.	Arginine	0-8	lactate dehydrogenase A	Rattus norvegicus	59-63
31056736-4	2019	The present study examines the effect of charged amino acids Arg, Asp, and Lys on the stability of RNase A and alpha-LA.	Arginine	61-64	ribonuclease A family member 1, pancreatic	Homo sapiens	99-106
30651352-8	2019	Substitutions of this arginine residue rendered mTORC1 signaling insensitive to amino acid starvation and are found frequently in cancers such as glioblastoma.	Arginine	22-30	CREB regulated transcription coactivator 1	Mus musculus	48-54
32321555-5	2020	We further provide evidence that the levels of HIF-1alpha and LDHA are increased after rat I/R injury and that arginine treatment prevents the elevation of HIF-1alpha and LDHA after I/R injury.	Arginine	111-119	lactate dehydrogenase A	Rattus norvegicus	171-175
32321555-6	2020	Arginine inhibits inflammatory response through suppression of HIF-1alpha and LDHA in the rat ischemic brain tissue and in the cultured microglia following OGD insult, and protects against ischemic neuron death after rat I/R injury by attenuating HIF-1alpha/LDHA-mediated inflammatory response.	Arginine	0-8	lactate dehydrogenase A	Rattus norvegicus	78-82
31307994-4	2019	We suggest that NEP-based BNP cleavage at position 17-18 results in BNP ring opening and formation of a novel epitope with C-terminal Arg-17 (BNP-neo17 form).	Arginine	134-137	natriuretic peptide B	Homo sapiens	26-29
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	superoxide dismutase 2	Homo sapiens	196-200
32321555-6	2020	Arginine inhibits inflammatory response through suppression of HIF-1alpha and LDHA in the rat ischemic brain tissue and in the cultured microglia following OGD insult, and protects against ischemic neuron death after rat I/R injury by attenuating HIF-1alpha/LDHA-mediated inflammatory response.	Arginine	0-8	lactate dehydrogenase A	Rattus norvegicus	258-262
32321555-7	2020	Together, these results indicate a possibility that arginine-induced neuroprotective effect may be through the suppression of HIF-1alpha/LDHA-mediated inflammatory response in microglia after cerebral ischemia injury.	Arginine	52-60	lactate dehydrogenase A	Rattus norvegicus	137-141
32447890-5	2020	Before and after the intervention, the scores of DAP-R scale tended to be death fear dimension and acceptance dimension, the proportion of the death fear dimension was 16.7% (10/60) and 6.7% (4/60) , respectively, and the approaching acceptance dimension was 83.3% (50/60) and 93.3% (56/60) .	Arginine	53-54	death associated protein	Homo sapiens	49-52
30746556-1	2019	PURPOSE: Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart containing two additional excipients: niacinamide, to increase early absorption, and L-arginine, to optimize stability.	Arginine	178-188	insulin	Sus scrofa	21-28
30728077-3	2019	Levels of arginine are regulated by the enzymes arginase 1,2 and nitric oxide synthase (NOS).	Arginine	10-18	arginase, liver	Mus musculus	48-58
30728077-3	2019	Levels of arginine are regulated by the enzymes arginase 1,2 and nitric oxide synthase (NOS).	Arginine	10-18	nitric oxide synthase 1, neuronal	Mus musculus	65-86
30728077-11	2019	Our ex vivo analysis demonstrated that myeloid derived suppressor cell (MDSC)s cause T cell suppression by arginine depletion, and suppression of arginase activity by a novel ARG1/2 inhibitor, compound 9, led to restoration of T cell function by increasing arginine.	Arginine	257-265	arginase, liver	Mus musculus	175-181
30194449-0	2019	Arginine refolds, stabilizes, and restores function of mutant pVHL proteins in animal model of the VHL cancer syndrome.	Arginine	0-8	von Hippel-Lindau tumor suppressor	Homo sapiens	62-66
30194449-4	2019	Among various chemical chaperones tested, arginine was the most effective in refolding mutant of pVHL.	Arginine	42-50	von Hippel-Lindau tumor suppressor	Homo sapiens	97-101
30194449-6	2019	Arginine treatment increased pVHL solubility in both models and increased the half-life of the mutant pVHL proteins in the cell culture.	Arginine	0-8	von Hippel-Lindau tumor suppressor	Homo sapiens	29-33
30194449-6	2019	Arginine treatment increased pVHL solubility in both models and increased the half-life of the mutant pVHL proteins in the cell culture.	Arginine	0-8	von Hippel-Lindau tumor suppressor	Homo sapiens	102-106
30194449-8	2019	Moreover, continuous feeding of Drosophila expressing misfolded versions of pVHL either L- or D-arginine rich diet rescued their lethal phenotype.	Arginine	96-104	von Hippel-Lindau tumor suppressor	Homo sapiens	76-80
30697165-6	2018	Allosteric modulators of calcium-sensing receptor (CaSR) and G-protein coupled receptor class C group 6 member A (GPRC6A) had inhibitory effects on cell death induced by L-arginine but not L-ornithine or L-histidine.	Arginine	170-180	calcium-sensing receptor	Mus musculus	25-49
30697165-6	2018	Allosteric modulators of calcium-sensing receptor (CaSR) and G-protein coupled receptor class C group 6 member A (GPRC6A) had inhibitory effects on cell death induced by L-arginine but not L-ornithine or L-histidine.	Arginine	170-180	calcium-sensing receptor	Mus musculus	51-55
30625312-1	2019	The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to regulate gene transactivation through profiling or Carm1 overexpression assays.	Arginine	27-35	coactivator-associated arginine methyltransferase 1	Mus musculus	54-59
30625312-1	2019	The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to regulate gene transactivation through profiling or Carm1 overexpression assays.	Arginine	27-35	coactivator-associated arginine methyltransferase 1	Mus musculus	228-233
30625312-1	2019	The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to regulate gene transactivation through profiling or Carm1 overexpression assays.	Arginine	100-108	coactivator-associated arginine methyltransferase 1	Mus musculus	54-59
30625312-1	2019	The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to regulate gene transactivation through profiling or Carm1 overexpression assays.	Arginine	100-108	coactivator-associated arginine methyltransferase 1	Mus musculus	228-233
30389668-3	2019	Here, we investigated how methylation of arginine 37 (R37Me) and acetylation of lysine 49 (K49Ac) on the CENP-A homolog Cse4 from Saccharomyces cerevisiae regulate molecular interactions at the inner kinetochore.	Arginine	41-49	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	120-124
30414414-2	2019	A mutation (m.9176 T &gt; G) of the mitochondrial ATP6 gene that replaces an universally conserved leucine residue into arginine at amino acid position 217 of human subunit a (aL217R) has been associated to NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) and MILS (Maternally Inherited Leigh"s Syndrome) diseases.	Arginine	120-128	mitochondrially encoded ATP synthase 6	Homo sapiens	50-54
30355733-3	2018	Here, combining in vitro interaction studies with computational docking and molecular dynamics of existing X-ray structures for the Spi1 and C/EBPbeta DBDs, along with the C/EBPbeta C-terminal tail sequence, we found that the tail sequence is intimately associated with Arg-232 of Spi1.	Arginine	270-273	CCAAT enhancer binding protein beta	Homo sapiens	172-181
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	4-7	CCAAT enhancer binding protein beta	Homo sapiens	215-224
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	124-134	CCAAT enhancer binding protein beta	Homo sapiens	215-224
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	CCAAT enhancer binding protein beta	Homo sapiens	163-172
30583600-6	2018	Inflammation was ameliorated by suppression of Arg-1 to adjust the disturbed metabolic pathways induced by aPM2.5, such as arginine and nitrogen metabolism and aminoacyl-tRNA biosynthesis, for 11 weeks.	Arginine	123-131	arginase 1	Rattus norvegicus	47-52
30151892-0	2018	Thalassemia major phenotype caused by HB Zurich-Albisrieden [alpha2 59(E8) Gly &gt; Arg (HBA2:C.178G &gt; C)] in a Brazilian child.	Arginine	84-87	hemoglobin subunit alpha 2	Homo sapiens	89-93
30230652-4	2018	We find that P. merdae GUS exhibits a distinct tetrameric quaternary structure and that the mL2 motif traces a unique path within the active site, which also includes two arginines distinctive to this GUS.	Arginine	171-180	glucuronidase beta	Homo sapiens	201-204
30451821-5	2018	RORgammat is SUMO3-modified by E3 ligase PIAS4 at lysine 31 (K31), and the mutation of K31 to arginine in mice prevents RORgammat sumoylation, leading to impaired TH17 differentiation, resistance to TH17-mediated EAE, accumulation of thymic ISPs, and a lack of Peyer"s patches.	Arginine	94-102	small ubiquitin-like modifier 3	Mus musculus	13-18
30303311-9	2018	At those time points, the ARG level and the A/A ratio were decreased in groups CIR and SIR as compared to groups C and S, respectively.	Arginine	26-29	corepressor interacting with RBPJ, 1	Rattus norvegicus	79-82
29478426-11	2018	In ovo feeding of Arg also enhanced mammalian target of rapamycin, ribosomal protein S6 kinase-1 and eIF4E-bindingprotein-1 messenger RNA expression levels at hatch compared with those of control groups (P&lt;0.05).	Arginine	18-21	eukaryotic translation initiation factor 4E	Homo sapiens	101-106
30375474-2	2018	MALT1 is a unique enzyme among this clan because it recognizes the basic amino acid arginine in the P1 pocket.	Arginine	84-92	MALT1 paracaspase	Homo sapiens	0-5
30332648-5	2018	Integrated transcriptome and protein-protein interaction studies revealed an enrichment of genes implicated in RAS signaling and showed that PRMT6 interacted with CRAF on arginine 100, which decreased its RAS binding potential and altered its downstream MEK/ERK signaling.	Arginine	171-179	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	163-167
30332648-6	2018	Our work describes a critical repressive function for PRMT6 in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100.	Arginine	163-171	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	155-159
30307304-3	2018	Two sessions of aerobic exercise were performed proceeded for the ingestion of one dose of 7 g of L-arginine (EX-LARG) or placebo (EX-PLA), plus one session only with L-arginine ingestion (L-ARG).	Arginine	98-108	Rho guanine nucleotide exchange factor 12	Homo sapiens	113-117
30288668-2	2018	Arginase-I (ARGI) accumulation at sites of amyloid-beta (Abeta) deposition is associated with L-arginine deprivation and neurodegeneration.	Arginine	94-104	arginase, liver	Mus musculus	0-10
30066894-16	2018	In conclusion, inhibition of ODC1 by DFMO was crucial in facilitating BCT-100 treatment in lung adenocarcinoma that was partially mediated by depleting arginine and polyamines with consequent apoptosis.	Arginine	152-160	ornithine decarboxylase 1	Homo sapiens	29-33
31326582-1	2019	Protein arginine methylation is a prevalent posttranslational modification and protein arginine methyltransferases 6 (PRMT6) has been identified as a suppressor of TBK1/IRF3 in human and mammals.	Arginine	8-16	interferon regulatory factor 3	Homo sapiens	169-173
31618764-10	2019	This arginine residue is highly conserved in all selected OAS3 orthologs.	Arginine	5-13	2'-5'-oligoadenylate synthetase 3	Homo sapiens	58-62
31299085-8	2019	Finally, Ribo-Seq analysis revealed that loss of New1 leads to ribosome queuing upstream of 3"-terminal lysine and arginine codons, including those genes encoding proteins of the cytoplasmic translational machinery.	Arginine	115-123	New1p	Saccharomyces cerevisiae S288C	49-53
31284097-2	2019	In this study, a CD133+ EPC capture surface was fabricated by grafting CD133 antibody (a more specific EPC surface marker than CD34) and Arg-Glu-Asp-Val (REDV) peptideon the methacrylate-grafted hyaluronic acid (MA-HA) and heparin-hybridized (MA-HA&amp;Heparin) resisting layer.	Arginine	137-140	prominin 1	Homo sapiens	17-22
31177351-7	2019	This was not associated with a lack of enzymatic activity but instead was due to constitutive expression of the Arg-1 enzyme at the mRNA and protein levels, suggesting that arginase restricts availability of L-arginine as a substrate for NOS II to synthesize NO.	Arginine	208-218	arginase 1	Homo sapiens	112-117
31439799-4	2019	Nuclear magnetic resonance spectroscopy of FMRP-CAPRIN1 condensates revealed interactions involving arginine-rich and aromatic-rich regions.	Arginine	100-108	nuclear FMR1 interacting protein 2	Homo sapiens	43-47
31437223-9	2019	By substituting basic residues with alanine within this sequence, we demonstrated that the JDV Rev NLS encompasses aa 76 to 86, and is exclusively composed of arginine residues, whereas a bipartite NoLS was observed for the first time in any retroviral Rev/Rev-like proteins.	Arginine	159-167	Rev	Human immunodeficiency virus 1	95-98
31646104-1	2019	Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of L-arginine, a nutrient required for T-cells expansion.	Arginine	117-127	arginase 1	Homo sapiens	14-24
31646104-1	2019	Expression of arginase-1 (ARG1) is an immunosuppressive feature of tumor microenvironment that leads to depletion of L-arginine, a nutrient required for T-cells expansion.	Arginine	117-127	arginase 1	Homo sapiens	26-30
31142511-4	2019	Mechanistically, the N-terminal SRC homology 3 domains of CIN85 interacted with the proline-arginine-rich region within the N-terminus of PHD2, thereby inhibiting PHD2 activity and HIF degradation.	Arginine	92-100	SH3-domain kinase binding protein 1	Mus musculus	58-63
31428054-6	2019	Results: We identified a heterozygous DUOX1 missense mutation (G &gt; A base substitution at nucleotide 3920 in exon 31) that changed a highly conserved arginine to glutamine at residual 1307 (p.R1307Q) in patient 1.	Arginine	153-161	dual oxidase 1	Homo sapiens	38-43
31149961-16	2019	Myeloid-derived suppressor cells are known to impair immune cell functions by expression of the arginine-degrading enzyme arginase-1.	Arginine	96-104	arginase 1	Homo sapiens	122-132
31067316-6	2019	Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B.	Arginine	250-253	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	132-138
31067316-6	2019	Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B.	Arginine	250-253	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	276-282
31029307-3	2019	The docking and molecular dynamic study revealed that the R-BMHP1 sequence induced a stronger electrostatic interaction than BMP2 through arginines in the RADA core sequence and through lysine24 in the BMHP1 motif with BMPR1A.	Arginine	138-147	bone morphogenetic protein 2	Rattus norvegicus	125-129
31158736-4	2019	Results revealed that l-arginine increased the testosterone levels declined by T-2 toxin and up-regulated the activities and mRNA expression of P450scc, 3beta-HSD-1 and StAR down-regulated by T-2 toxin in Leydig cells.	Arginine	22-32	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	144-151
31158736-5	2019	Therefore, we concluded that l-arginine ameliorated the testosterone levels decreased by T-2 Toxin via regulating the mRNA expression and activities of P450scc, 3beta-HSD-1 and StAR in mouse Leydig cells.	Arginine	29-39	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	152-159
31362433-3	2019	We studied the interaction of mucin with the bio-inspired arginine-derived amphoteric polymer d,l-ARGO7 by applying complementary techniques.	Arginine	58-66	LOC100508689	Homo sapiens	30-35
31217391-5	2019	It decreased MI/R-induced activation of caspase 9, the indicator of the intrinsic mitochondrial pathway, but not caspase 8.	Arginine	16-17	caspase 9	Mus musculus	40-49
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Arginine	99-102	keratin 27	Homo sapiens	30-33
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Arginine	99-102	calcium binding and coiled-coil domain 2	Homo sapiens	145-150
31334320-1	2019	SRPK1 is an evolutionary conserved protein kinase that specifically phosphorylates its substrates at serine residues located within arginine-serine-rich (RS) domains.	Arginine	132-140	SRSF protein kinase 1	Homo sapiens	0-5
30907440-4	2019	RESULTS: When comparing the three CYP2B6 genotype groups, the methadone (R)- and (S)-methadone enantiomer concentrations/doses (concentrations relative to doses) were different (P = .029, P = .0019).	Arginine	73-75	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-40
31216483-4	2019	The action of Galphaq depends on binding to three arginine residues in the N terminus of TRPM8.	Arginine	50-58	transient receptor potential cation channel subfamily M member 8	Homo sapiens	89-94
31207968-0	2019	Effect of In Ovo Injection of L-Arginine in Different Chicken Embryonic Development Stages on Post-Hatchability, Immune Response, and Myo-D and Myogenin Proteins.	Arginine	30-40	myogenin	Gallus gallus	144-152
30547280-3	2019	The LIM was modified by arginine to improve its water solubility and biological activities.	Arginine	24-32	PDZ and LIM domain 5	Mus musculus	4-7
30131339-6	2018	The M2 isoform of PK (PKM2) is arginine-methylated by CARM1, and methylation enhances its activity.	Arginine	31-39	pyruvate kinase, muscle	Mus musculus	18-20
30131339-6	2018	The M2 isoform of PK (PKM2) is arginine-methylated by CARM1, and methylation enhances its activity.	Arginine	31-39	pyruvate kinase, muscle	Mus musculus	22-26
32328638-5	2020	We observed that FXR1 alternative splicing is pronounced in the serine- and arginine-rich intrinsically disordered domain; these domains are known to promote biomolecular condensation.	Arginine	76-84	FMR1 autosomal homolog 1	Danio rerio	17-21
30131339-6	2018	The M2 isoform of PK (PKM2) is arginine-methylated by CARM1, and methylation enhances its activity.	Arginine	31-39	coactivator-associated arginine methyltransferase 1	Mus musculus	54-59
30131339-7	2018	Mechanistically, CARM1 methylates PKM2 at arginines 445 and 447, which enhances PKM2 tetramer formation.	Arginine	42-51	coactivator-associated arginine methyltransferase 1	Mus musculus	17-22
30131339-7	2018	Mechanistically, CARM1 methylates PKM2 at arginines 445 and 447, which enhances PKM2 tetramer formation.	Arginine	42-51	pyruvate kinase, muscle	Mus musculus	34-38
30131339-7	2018	Mechanistically, CARM1 methylates PKM2 at arginines 445 and 447, which enhances PKM2 tetramer formation.	Arginine	42-51	pyruvate kinase, muscle	Mus musculus	80-84
30254218-3	2018	A1 competes with nitric oxide synthase (NOS) for their common substrate L-arginine.	Arginine	72-82	arginase, liver	Mus musculus	0-2
31149712-0	2019	N-Carbamylglutamate and l-Arginine Promote Intestinal Absorption of Amino Acids by Regulating the mTOR Signaling Pathway and Amino Acid and Peptide Transporters in Suckling Lambs with Intrauterine Growth Restriction.	Arginine	24-34	serine/threonine-protein kinase mTOR	Ovis aries	98-102
31149712-10	2019	Furthermore, dietary NCG or Arg treatment normalized the IUGR-induced variation (P &lt; 0.05) in the ileal ratio of phosphorylated mTOR to total mTOR protein.	Arginine	28-31	serine/threonine-protein kinase mTOR	Ovis aries	131-135
31149712-10	2019	Furthermore, dietary NCG or Arg treatment normalized the IUGR-induced variation (P &lt; 0.05) in the ileal ratio of phosphorylated mTOR to total mTOR protein.	Arginine	28-31	serine/threonine-protein kinase mTOR	Ovis aries	145-149
30254218-3	2018	A1 competes with nitric oxide synthase (NOS) for their common substrate L-arginine.	Arginine	72-82	nitric oxide synthase 1, neuronal	Mus musculus	17-38
32111629-7	2020	Our results showed reduced levels of sumoylation of mutant Cse4 K215/216R/A (K changed to arginine (R) or alanine (A)) and reduced interaction of mutant Cse4 K215/215R/A with Scm3 and CAF-1 when compared to wild type Cse4.	Arginine	90-98	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	59-63
30250194-0	2018	The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesis.	Arginine	12-20	DEAD-box helicase 56	Homo sapiens	100-121
30808730-6	2019	Profiling of the metabolome demonstrates that suppression of CPS1 potentiates the effects of EGFR inhibition on central carbon metabolism, pyrimidine biosynthesis, and arginine metabolism, coinciding with reduced glycolysis and mitochondrial respiration.	Arginine	168-176	carbamoyl-phosphate synthase 1	Homo sapiens	61-65
30808730-7	2019	We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous pyrimidines partially rescues the impairment in cell growth.	Arginine	70-78	carbamoyl-phosphate synthase 1	Homo sapiens	33-37
30890279-1	2019	AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea.	Arginine	36-46	arginase 1	Homo sapiens	5-15
30890279-1	2019	AIM: Arginase-1 (Arg-1) metabolizes l-arginine to l-ornithine and urea.	Arginine	36-46	arginase 1	Homo sapiens	17-22
32091410-1	2020	Protein arginine methyltransferase 5 (PRMT5) catalyzes symmetric dimethylation (SDM) of arginine, a posttranslational modification involved in oncogenesis and embryonic development.	Arginine	8-16	protein arginine N-methyltransferase 5	Mus musculus	38-43
32086375-0	2020	Arginine in C9ORF72 dipolypeptides mediates promiscuous proteome binding and multiple modes of toxicity.	Arginine	0-8	C9orf72-SMCR8 complex subunit	Homo sapiens	12-19
30892606-2	2019	We identified a ULM (UHM ligand motif) motif in the Arginine-Rich Motif (ARM) of the Rev protein.	Arginine	52-60	Rev	Human immunodeficiency virus 1	85-88
30017564-6	2018	Exposed bases of the aptamer interleave with the guanidinium groups of two arginines of Rev, forming stacking interactions and hydrogen bonds.	Arginine	75-84	Rev	Human immunodeficiency virus 1	88-91
32209476-0	2020	OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.	Arginine	49-57	protein arginine N-methyltransferase 5	Mus musculus	24-29
29574762-8	2018	The abundance of Th17 cells and IL-23+ cells in relevant draining lymph nodes was significantly reduced in Arg II knockout mice.	Arginine	107-110	interleukin 23, alpha subunit p19	Mus musculus	32-37
30842273-0	2019	Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production.	Arginine	39-42	interferon regulatory factor 3	Mus musculus	52-56
30842273-4	2019	IRF3 is phosphorylated by c-Abl and c-Abl-related kinase, Arg, mainly at Y292.	Arginine	58-61	interferon regulatory factor 3	Mus musculus	0-4
30842273-8	2019	holarctica live vaccine strain (Ft LVS), which is known as an activator of AIM2 inflammasome, induces death in significantly more C57BL/6 mice treated with the Abl inhibitor AMN107 or c-Abl/Arg small interfering RNA than in untreated mice.	Arginine	190-193	absent in melanoma 2	Mus musculus	75-79
30042193-6	2018	Comparisons of gene expression profiles in kidney tissues at P22 and P30 in PKD and WT mice revealed that arginine metabolism was significantly activated; 204 differentially expressed genes (DEGs), including Arg1, an arginine metabolism-associated gene, were identified in late-stage polycystic kidneys.	Arginine	106-114	high mobility group box 1	Mus musculus	69-72
30842273-9	2019	This study provides new insight into the function of c-Abl and Arg in regulating immune responses and AIM2 inflammasome activation, especially against Ft LVS infection.	Arginine	63-66	absent in melanoma 2	Mus musculus	102-106
31932825-3	2020	During Env immunogen production, endogenous furin works to cleave a hexa-arginine motif connecting the gp120 and gp41 subunits, which is needed to ensure proper protein folding and a native-like conformation of Env.	Arginine	73-81	furin, paired basic amino acid cleaving enzyme	Homo sapiens	44-49
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Arginine	206-209	relaxin family peptide receptor 3	Homo sapiens	164-169
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Arginine	344-347	relaxin family peptide receptor 3	Homo sapiens	164-169
30042193-6	2018	Comparisons of gene expression profiles in kidney tissues at P22 and P30 in PKD and WT mice revealed that arginine metabolism was significantly activated; 204 differentially expressed genes (DEGs), including Arg1, an arginine metabolism-associated gene, were identified in late-stage polycystic kidneys.	Arginine	106-114	arginase, liver	Mus musculus	208-212
30055993-1	2018	Arginine is a semi-essential amino acid which serves as a substrate for nitric oxide (NO) production by nitric oxide synthase (NOS) and a precursor for various metabolites including ornithine, creatine, polyamines, and agmatine.	Arginine	0-8	nitric oxide synthase 1, neuronal	Mus musculus	104-125
31692054-5	2020	In this study, we explored the function of Chrm3 gene in the regulation of cell death in l-arginine-induced SAP animal models.	Arginine	89-99	cholinergic receptor, muscarinic 3, cardiac	Mus musculus	43-48
30096423-5	2018	Caucasian EPHX2 Arg55 carriers (Lys/Arg or Arg/Arg) had a significantly higher risk of 5-year mortality (adjusted hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.01-2.55, P = 0.045).	Arginine	16-19	epoxide hydrolase 2	Homo sapiens	10-15
30096423-5	2018	Caucasian EPHX2 Arg55 carriers (Lys/Arg or Arg/Arg) had a significantly higher risk of 5-year mortality (adjusted hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.01-2.55, P = 0.045).	Arginine	36-39	epoxide hydrolase 2	Homo sapiens	10-15
30797943-4	2019	We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins.	Arginine	143-151	arginase 1	Homo sapiens	79-89
30797943-4	2019	We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins.	Arginine	143-151	arginase 1	Homo sapiens	91-95
30096423-5	2018	Caucasian EPHX2 Arg55 carriers (Lys/Arg or Arg/Arg) had a significantly higher risk of 5-year mortality (adjusted hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.01-2.55, P = 0.045).	Arginine	36-39	epoxide hydrolase 2	Homo sapiens	10-15
31641819-8	2020	Pre-treatment with ARG and/or CAR significantly mitigated the neural changes induced by hypoxia and attenuated the elevated levels of NF-kappaB, TNF-alpha, IL-6, caspase-3, and BAX, while ameliorated the reduced levels of Bcl-2, NADR, DOP, SER, and GABA, with the best improvement observed with the combination.	Arginine	19-22	caspase 3	Rattus norvegicus	162-171
30595031-2	2019	The present experiment was designed to examine arginine (Arg)-sparing effects of guanidinoacetic acid (GAA) on production performance, intestinal morphology and certain blood parameters in broiler chickens.	Arginine	47-55	alpha glucosidase 2	Gallus gallus	103-106
31243342-0	2020	Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70.	Arginine	70-78	mitogen-activated protein kinase 14	Mus musculus	59-66
30595031-13	2019	Dietary inclusion of GAA had an Arg-sparing effect, whereby 1.2 and 1.8 g/kg of supplemental GAA resulted in greater growth performance during the starter and entire rearing periods, respectively.	Arginine	32-35	alpha glucosidase 2	Gallus gallus	21-24
30659259-5	2019	SLC7A2 was associated with the plasma levels of arginine and ornithine, and PKD1L2 with the level of glycine.	Arginine	48-56	solute carrier family 7 member 2	Homo sapiens	0-6
31531056-13	2019	In addition, Arginine residue was found to contribute significantly in interaction of ClTxs with hMMP-2.	Arginine	13-21	matrix metallopeptidase 2	Homo sapiens	97-103
30054395-12	2018	PRMT8-dependent arginine methylation is required for neuroprotection against age-related increased of cellular stress.	Arginine	16-24	protein arginine N-methyltransferase 8	Mus musculus	0-5
30154485-1	2018	Protein arginine methylation is a novel form of posttranslational modification mediated by protein arginine methyltransferase (PRMTs).	Arginine	8-16	coactivator-associated arginine methyltransferase 1	Mus musculus	91-125
31885210-4	2020	Significant higher OPN expression is found in foam cells along with the aggravating capacity of macrophage recruitment due to its arginine-glycine-aspartate sequence and interaction with CD44.	Arginine	130-138	secreted phosphoprotein 1	Mus musculus	19-22
30642176-3	2019	A structural feature of LOX-1 relevant to oxLDL binding is the "basic spine" motif consisting of linearly aligned arginine residues stretched over the dimer surface.	Arginine	114-122	oxidized low density lipoprotein receptor 1	Homo sapiens	24-29
32761572-12	2020	There is evidence to suggest that the arginine/NO pathway may be involved in modulating some of the effects of ghrelin on cells.	Arginine	38-46	ghrelin	Mus musculus	111-118
29704548-5	2018	VCP is bound directly by ataxin-3 through an arginine-rich area preceding the polyQ repeat.	Arginine	45-53	TER94	Drosophila melanogaster	0-3
29950483-3	2018	Here, we report that the protein arginine methyltransferase 5 (Prmt5) and symmetric dimethylation at histone H4 arginine 3 (H4R3sme2) directly associate with chromatin of Bmp4 to suppress its transcription.	Arginine	33-41	bone morphogenetic protein 4	Homo sapiens	171-175
29950483-6	2018	Inhibition of BMP signaling by Noggin rescues the lung branching defects of Prmt5 mutant in vitro Taken together, our results identify a novel mechanism through which Prmt5-mediated histone arginine methylation represses canonical BMP signaling to regulate lung branching morphogenesis.	Arginine	190-198	noggin	Homo sapiens	31-37
30610061-8	2019	Mechanistically, Arg-II appears to cause OA cartilage destruction at least partly by upregulating the expression of matrix-degrading enzymes (matrix metalloproteinase 3 [MMP3] and MMP13) in chondrocytes via the nuclear factor (NF)-kappaB pathway.	Arginine	17-20	matrix metallopeptidase 13	Mus musculus	180-185
31114027-6	2020	The UBAP2L Arg-Gly-Gly (RGG) motif was required for SG competence, and mediated the recruitment of SG components, including mRNPs, RBPs, and ribosomal subunits.	Arginine	11-14	ubiquitin associated protein 2 like	Homo sapiens	4-10
30844724-2	2019	Amino acids, especially leucine, arginine and glutamine, signal to mTORC1 activation.	Arginine	33-41	CREB regulated transcription coactivator 1	Mus musculus	67-73
31672462-2	2020	NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS).	Arginine	23-33	nitric oxide synthase 1	Homo sapiens	176-180
30228936-3	2018	This increase contributes to an immunosuppressive tumor microenvironment in MPN patients because of L-arginine depletion by Arginase-1-expressing regulatory cells and cancer cells, which subsequently limits the activation of circulating effector cells.	Arginine	100-110	arginase 1	Homo sapiens	124-134
31666358-2	2020	Through its pantetheine-4"-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family.	Arginine	125-133	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	70-77
30029003-4	2018	Chemical and genetic perturbation of mTORC1 and GCN2 signaling revealed that their robust response to leucine limitation prevents ribosome pausing, while an insufficient response to arginine limitation leads to loss of tRNA charging and ribosome pausing.	Arginine	182-190	CREB regulated transcription coactivator 1	Mus musculus	37-43
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	semaphorin 3A	Homo sapiens	97-110
30022074-0	2018	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.	Arginine	34-42	C9orf72-SMCR8 complex subunit	Homo sapiens	13-20
30022074-4	2018	This requires p62 to associate via the Tudor protein SMN with proteins, including FUS, that are symmetrically methylated on arginines.	Arginine	124-133	survival of motor neuron 1, telomeric	Homo sapiens	53-56
30022074-6	2018	Patients with C9ORF72 repeat expansions accumulate symmetric arginine dimethylated proteins which co-localize with p62.	Arginine	61-69	C9orf72-SMCR8 complex subunit	Homo sapiens	14-21
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	semaphorin 3A	Homo sapiens	112-118
31649033-9	2019	Molecular modeling and mutagenesis of AKR1A1 identified Arg-312 as a key residue mediating the specific interaction with GSNO; in contrast, substitution of the SNO-CoA-binding residue Lys-127 minimally affected the GSNO-reducing activity of AKR1A1.	Arginine	56-59	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	38-44
29773653-1	2018	Protein arginine methyltransferase 5 (PRMT5) regulates gene expression either transcriptionally by symmetric dimethylation of arginine residues on histones H4R3, H3R8, and H2AR3 or at the posttranslational level by methylation of nonhistone target proteins.	Arginine	8-16	protein arginine N-methyltransferase 5	Mus musculus	38-43
29773710-8	2018	In the case of the transcription factor Smad4, we showed that a unique arginine methylation site was required for GSK3 phosphorylation and Wnt regulation.	Arginine	71-79	SMAD family member 4	Homo sapiens	40-45
31743939-9	2019	The functional studies on the bacterial and heterologous mammalian cells revealed that the arginine at position 99 is essential for the stability of ARL3.	Arginine	91-99	ADP ribosylation factor like GTPase 3	Homo sapiens	149-153
31391274-5	2019	UL31 residues arginine-281 (R281) and aspartic acid-282 (D282) were required for efficient NEC binding to nucleocapsids and UL25.	Arginine	14-22	nuclear egress lamina protein	Human alphaherpesvirus 1	0-4
29394130-1	2018	MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines.	Arginine	144-153	PR/SET domain 9	Homo sapiens	59-84
29394130-1	2018	MDM2 antagonists stabilize and activate wild-type p53, and histone methyltransferase (HMT) inhibitors reduce methylation on histone lysines and arginines.	Arginine	144-153	PR/SET domain 9	Homo sapiens	86-89
31352175-4	2019	Our results showed that levels of ERbeta and PGR expression were significantly increased by nutrient restriction, but L-Arg counteracted the effect of nutrient restriction on ERbeta and PGR expression (p < 0.05).	Arginine	118-123	progesterone receptor	Ovis aries	186-189
29928487-8	2018	Nucleolin directly bound to TRA2beta4 exon 2 via the glycine/arginine-rich (GAR) domain.	Arginine	61-69	nucleolin	Homo sapiens	0-9
31352175-9	2019	The expression levels of endothelial nitric oxide synthase, ERbeta, and PGR were significantly increased in response to low-concentration (200 mumol) L-Arg supplementation, which subsequently decreased with a high concentration (800 mumol) (p < 0.05).	Arginine	150-155	progesterone receptor	Ovis aries	72-75
29890043-5	2018	Depletion of circulating arginine by intravenous infusion of arginase 1 or inhibition of nitric oxide synthase activity with L-NG -nitro-arginine methyl ester increased mean arterial pressure similarly in control (9 +- 2 and 34 +- 2 mmHg, respectively) and Arg1-KOTie2 mice (11 +- 3 and 38 +- 4 mmHg, respectively).	Arginine	25-33	arginase, liver	Mus musculus	61-71
31383768-6	2019	An AC6-N mutant, AC6-N-3A, in which three consecutive arginine residues are mutated to alanine residues, altered both binding to 4.1G-FERM and its plasma membrane distribution in vivo.	Arginine	54-62	adenylate cyclase 6	Homo sapiens	3-8
31383768-6	2019	An AC6-N mutant, AC6-N-3A, in which three consecutive arginine residues are mutated to alanine residues, altered both binding to 4.1G-FERM and its plasma membrane distribution in vivo.	Arginine	54-62	adenylate cyclase 6	Homo sapiens	17-22
30448461-6	2019	Of these, the arginine/glycine site of SON mRNA was newly identified as an ADAR2-dependent site.	Arginine	14-22	adenosine deaminase RNA specific B1	Homo sapiens	75-80
29604130-8	2018	Four of these RNF146 motifs represent novel, extended TBMs, that have one or two additional amino acids between the most conserved Arg and Gly residues.	Arginine	131-134	ring finger protein 146	Homo sapiens	14-20
29695495-3	2018	Here, we found that the Drosophila Mre11 is methylated at arginines 559, 563, 565, and 569 in the GAR motif by DART1, the Drosophila homolog of PRMT1.	Arginine	58-67	Arginine methyltransferase 1	Drosophila melanogaster	111-116
29695495-9	2018	Thus, we provided evidence that arginines in Drosophila Mre11 are methylated by DART1 methytransferase and flies loss of arginine methylation are sensitive to irradiation.	Arginine	32-41	Arginine methyltransferase 1	Drosophila melanogaster	80-85
29695495-9	2018	Thus, we provided evidence that arginines in Drosophila Mre11 are methylated by DART1 methytransferase and flies loss of arginine methylation are sensitive to irradiation.	Arginine	32-40	Arginine methyltransferase 1	Drosophila melanogaster	80-85
31469551-0	2019	Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.	Arginine	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	76-92
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Arginine	232-240	tripartite motif containing 26	Homo sapiens	20-26
31541129-3	2019	Here we show that mice with experimental cerebral malaria (ECM) by P. berghei ANKA showed marked decreases in CBF (as assessed by laser speckle contrast imaging - LSCI) and that administration of L-arginine supplementation (50 mg/kg) and/or of the thromboxane synthase inhibitor Ozagrel (100 mg/kg) induced immediate increases in CBF.	Arginine	196-206	thromboxane A synthase 1, platelet	Mus musculus	248-268
31513489-1	2019	The deletion of Arginine 14 of the phosholamban gene (PLN p.R14del) is associated with the pathogenesis of an inherited form of cardiomyopathy with prominent arrhythmias.	Arginine	16-24	phospholamban	Homo sapiens	54-57
29792217-2	2018	The hypothesis that the substantially increased expression of arginase 1 in activated macrophages limits the availability of L-arginine for nitric oxide synthesis, and thus increases AHR in lungs of mice with experimentally induced allergic asthma was recently refuted by several studies.	Arginine	125-135	arginase, liver	Mus musculus	62-72
29792217-4	2018	Female FVB F/A2 tg/tg transgenic mice, which overexpress rat arginase 1 in their enterocytes, exhibit a ~ 50% decrease of their plasma L-arginine concentration.	Arginine	135-145	arginase 1	Rattus norvegicus	61-71
31133753-5	2019	Following activation of CD4+ T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1).	Arginine	81-84	MALT1 paracaspase	Homo sapiens	174-179
29211299-11	2018	Above all, LOX-1+  CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress.	Arginine	112-115	oxidized low density lipoprotein receptor 1	Homo sapiens	11-16
31113844-0	2019	Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.	Arginine	0-8	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	54-59
29247719-3	2018	Thus, the purpose of this work was to test the idea that elevation of blood-to-brain l-arginine transport across the BBB in the postnatal period coincides with up-regulation of cationic acid transporter 1 (CAT1) expression in developing brain capillaries.	Arginine	85-95	solute carrier family 7 member 1	Rattus norvegicus	177-204
29247719-3	2018	Thus, the purpose of this work was to test the idea that elevation of blood-to-brain l-arginine transport across the BBB in the postnatal period coincides with up-regulation of cationic acid transporter 1 (CAT1) expression in developing brain capillaries.	Arginine	85-95	solute carrier family 7 member 1	Rattus norvegicus	206-210
29247719-10	2018	These findings strongly support our hypothesis and suggest that the supply of blood-born l-arginine to the brain via CAT1 at the BBB plays a key role in meeting the elevated demand for l-arginine in postnatal brain.	Arginine	89-99	solute carrier family 7 member 1	Rattus norvegicus	117-121
29247719-10	2018	These findings strongly support our hypothesis and suggest that the supply of blood-born l-arginine to the brain via CAT1 at the BBB plays a key role in meeting the elevated demand for l-arginine in postnatal brain.	Arginine	185-195	solute carrier family 7 member 1	Rattus norvegicus	117-121
31164374-9	2019	Arginine depletion with pegylated arginine deiminase (ADI-PEG 20) dramatically suppresses tumor growth and promotes survival of mice specifically with MYC-driven tumors, including in GEMMs, human cell line xenografts, and a patient-derived xenograft from a relapsed patient.	Arginine	0-8	myelocytomatosis oncogene	Mus musculus	151-154
29430769-7	2018	Moreover, exchange of various surface residues of SPIp for arginine and glutamate/aspartate outside the glutamine donor region influences the efficiency of modification by MTG.	Arginine	59-67	serine protease 3	Homo sapiens	172-175
31381567-7	2019	We also discovered that MBD9 preferentially interacts with acetylated histone H4 peptides, as well as those carrying mono- or dimethylated H3 lysine 4, or dimethylated H3 arginine 2 or 8.	Arginine	171-179	methyl-CPG-binding domain 9	Arabidopsis thaliana	24-28
29709017-13	2018	The DNA-protein interaction results revealed the importance of core residues (Tyr, Arg, and Lys) in a feasible WRKY-W-box DNA interaction.	Arginine	83-86	LOC100191122	Solanum lycopersicum	111-115
30861322-11	2019	Following analyses of LC-MS/MS results for citrullination sites and corresponding reactivity in immunodot assays, we determined the critical arginines in ID-1 for autoantigenicity: R33, R52, and R121.	Arginine	141-150	inhibitor of DNA binding 1, HLH protein	Homo sapiens	154-158
29510042-6	2018	Furthermore, the proteins on the surface of vesicles are essential for the uptake of arginine-rich CPPs: downregulation of nucleolin decreases the accumulation and digestion of proteins on the membrane suppresses translocation even more efficiently.	Arginine	85-93	nucleolin	Homo sapiens	123-132
31088907-1	2019	We discovered that 90.3% of patients with angiomyolipomas, lymphangioleiomyomatosis (LAM), and tuberous sclerosis complex (TSC) carry the arginine variant of codon 72 (R72) of TP53 and that R72 increases the risk for angiomyolipoma.	Arginine	138-146	TSC complex subunit 1	Mus musculus	123-126
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Arginine	276-279	cellular communication network factor 2	Mus musculus	94-98
30665936-1	2019	Arginase (Arg) 1 is expressed by hematopoietic (e.g., macrophages) and nonhematopoietic cells (e.g., endothelial cells) and converts l-arginine into ornithine and urea.	Arginine	133-143	arginase, liver	Mus musculus	0-16
31075315-10	2019	The cationic (CAT-1) and neutral (SNAT-1) amino acid transporters for L-ARG and L-CIT, respectively, were determined by Western blot.	Arginine	70-75	solute carrier family 7 member 1	Rattus norvegicus	14-19
30808864-1	2019	Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC).	Arginine	13-21	arginase 1	Homo sapiens	43-53
30808864-1	2019	Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC).	Arginine	13-21	arginase 1	Homo sapiens	55-59
30808864-10	2019	Serum arginine level was decreased significantly by PEGylated ARG1 in all xenografts.	Arginine	6-14	arginase 1	Homo sapiens	62-66
30808864-11	2019	Nonetheless intratumoral arginine level was decreased by PEGylated ARG1 in SK-MES-1 and SW900, not H520 xenografts.	Arginine	25-33	arginase 1	Homo sapiens	67-71
30808864-14	2019	Silencing of ARG2 re-sensitized the H520 xenografts to PEGylated ARG1 treatment, partially mediated through arginine depletion via G1 arrest and apoptosis.	Arginine	108-116	arginase 1	Homo sapiens	65-69
31362455-9	2019	The enzyme had a maximum activity at 37  C, pH 7.4-7.8 and thermal stability for 20 h at 37  C, and 90 days storage stability at 4  C. A. terreus ODC had a maximum affinity (Km) for l-ornithine, l-lysine and l-arginine (0.95, 1.34 and 1.4 mM) and catalytic efficiency (kcat/Km) (4.6, 2.83, 2.46 x 10-5 mM-1 s-1).	Arginine	208-218	ornithine decarboxylase 1	Homo sapiens	146-149
31330793-5	2019	This assumption was tested on visible spectra of mixed solutions of Arginine and Co(II) to be a simplified model of Co(II) interaction with keratin.	Arginine	68-76	cytochrome c oxidase subunit II	Ovis aries	116-122
30476558-5	2019	The Glu2.53(90)Arg and Trp6.48(280)Arg mutants had decreased affinity for GnRH.	Arginine	35-38	transient receptor potential cation channel subfamily C member 6	Homo sapiens	23-27
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Arginine	167-170	transient receptor potential cation channel subfamily C member 6	Homo sapiens	117-121
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Arginine	167-170	transient receptor potential cation channel subfamily C member 6	Homo sapiens	175-179
30476558-6	2019	Models showed that congenital Glu2.53(90)Lys and Glu2.53(90)Asp mutations disrupt interactions with Ser3.35(124) and Trp6.48(280) respectively, whereas the Glu2.53(90)Arg and Trp6.48(280)Arg mutations preserve intramolecular contacts, but increase distance between the transmembrane helices.	Arginine	187-190	transient receptor potential cation channel subfamily C member 6	Homo sapiens	117-121
31155767-5	2019	Increasing ARG quadratically increased (p &lt; 0.05) BWG and FI with reaching plateau at 14.7 g/kg, while linearly decreased (p &lt; 0.05) FCR, indicating that maximal performance required ARG no more than 14.7 g/kg in diets.	Arginine	11-14	FCR	Gallus gallus	139-142
31098988-2	2019	We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which has a PDZ motif (Thr-Arg-Leu), by yeast two-hybrid screening and revealed that PDZK1 enhances the transport activity of SMCT1.	Arginine	138-141	PDZ domain containing ring finger 3	Homo sapiens	29-64
30318155-0	2019	Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells.	Arginine	0-8	forkhead box P3	Homo sapiens	24-29
30318155-5	2019	The inhibition of arginine methylation confers gene expression profiles representing type I helper T cells to FOXP3+ T cells, which results in attenuated suppressive activity.	Arginine	18-26	forkhead box P3	Homo sapiens	110-115
30318155-7	2019	These results elucidate an important role of arginine methylation to enhance FOXP3 functions and are potentially applicable to modulate regulatory T cell functions.	Arginine	45-53	forkhead box P3	Homo sapiens	77-82
31098988-2	2019	We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which has a PDZ motif (Thr-Arg-Leu), by yeast two-hybrid screening and revealed that PDZK1 enhances the transport activity of SMCT1.	Arginine	138-141	PDZ domain containing ring finger 3	Homo sapiens	66-72
30880179-6	2019	L-NAME, ODQ, methylene blue and calmidazolium increased BPV-induced contraction in endothelium-intact aortae, whereas PP2 alone and combined treatment with L-arginine and L-NAME inhibited BPV-induced contraction.	Arginine	156-166	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	118-121
30639924-7	2019	These observations highlighted the importance of residues 67 (Asn in CA II, Gln in CA IX) and 130 (Asp in CA II, Arg in CA IX) in selective CA inhibitor targeting.	Arginine	113-116	carbonic anhydrase 9	Homo sapiens	120-125
30956113-0	2019	Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.	Arginine	45-53	CREB regulated transcription coactivator 1	Mus musculus	58-64
30632578-0	2019	Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects.	Arginine	48-56	galectin 3	Homo sapiens	71-81
30632578-1	2019	In the beta-d-galactopyranoside-binding protein galectin-3, synthetic inhibitors substituted at the 3-position of a thiodigalactoside core cause the formation of an aglycone binding pocket through the displacement of an arginine residue (Arg144) from its position in the apoprotein.	Arginine	220-228	galectin 3	Homo sapiens	48-58
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	117-125	CREB regulated transcription coactivator 1	Mus musculus	174-180
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	149-157	CREB regulated transcription coactivator 1	Mus musculus	174-180
30445466-6	2019	Depletion of RNF8 or expression of NONO with lysine to arginine substitutions at positions 279, 290 and 295 prolonged CHK1 phosphorylation over an extended period of time.	Arginine	55-63	non-POU domain containing octamer binding	Homo sapiens	35-39
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	63-71	CREB regulated transcription coactivator 1	Mus musculus	83-89
30680190-6	2019	Results: Compared with the Control or Ala group, the infusion of Arg led to greater expression of AA transporters (SLC7A2 and SLC7A8) and apparent uptake of free AA in the mammary gland, and was accompanied by greater milk yield, milk protein yield and milk efficiency (calculated by dividing milk yield over feed intake), together with lower concentration of urea N [regarded as an indicator of N utilization efficiency (NUE)] in blood and milk.	Arginine	65-68	solute carrier family 7 member 2	Bos taurus	115-121
30849519-8	2019	A lys151 to arginine mutant of TTF1 (TTF1K151R) is resistant to PMA- or HECW1-mediated ubiquitination and degradation.	Arginine	12-20	transcription termination factor 1	Homo sapiens	31-35
30680190-6	2019	Results: Compared with the Control or Ala group, the infusion of Arg led to greater expression of AA transporters (SLC7A2 and SLC7A8) and apparent uptake of free AA in the mammary gland, and was accompanied by greater milk yield, milk protein yield and milk efficiency (calculated by dividing milk yield over feed intake), together with lower concentration of urea N [regarded as an indicator of N utilization efficiency (NUE)] in blood and milk.	Arginine	65-68	solute carrier family 7 member 8	Bos taurus	126-132
30849519-8	2019	A lys151 to arginine mutant of TTF1 (TTF1K151R) is resistant to PMA- or HECW1-mediated ubiquitination and degradation.	Arginine	12-20	transcription termination factor 1	Homo sapiens	37-46
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	23-29
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	103-109
30417362-9	2019	Our results demonstrated that under the Abeta treatment, ornithine decarboxylase (ODC), a rate-limiting enzyme in the regulation of arginine catabolism, regulates microglial activation by altering the antizyme (AZ) + 1 ribosomal frameshift.	Arginine	132-140	ornithine decarboxylase 1	Homo sapiens	57-80
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	103-109
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	84-92	CREB regulated transcription coactivator 1	Mus musculus	23-29
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	84-92	CREB regulated transcription coactivator 1	Mus musculus	103-109
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	84-92	CREB regulated transcription coactivator 1	Mus musculus	103-109
30503338-4	2019	Three groups have resolved the structures of arginine-CASTOR1 complex, shedding a new light on molecular basis of the regulation of mTORC1 activity by arginine.	Arginine	45-53	CREB regulated transcription coactivator 1	Mus musculus	132-138
30503338-4	2019	Three groups have resolved the structures of arginine-CASTOR1 complex, shedding a new light on molecular basis of the regulation of mTORC1 activity by arginine.	Arginine	151-159	CREB regulated transcription coactivator 1	Mus musculus	132-138
30503338-9	2019	Therefore, we conclude a detailed structural interpretation of arginine sensing by CASTOR1 in mTORC1 pathway.	Arginine	63-71	CREB regulated transcription coactivator 1	Mus musculus	94-100
30417362-9	2019	Our results demonstrated that under the Abeta treatment, ornithine decarboxylase (ODC), a rate-limiting enzyme in the regulation of arginine catabolism, regulates microglial activation by altering the antizyme (AZ) + 1 ribosomal frameshift.	Arginine	132-140	ornithine decarboxylase 1	Homo sapiens	82-85
31110284-4	2019	Herein we report that Ser/Arg repetitive matrix 4 (SRRM4), a splicing activator, is abnormally expressed at high levels in SCLC and thus is a potential therapeutic target.	Arginine	26-29	serine/arginine repetitive matrix 4	Homo sapiens	51-56
31379141-5	2019	Recently, several sensors of leucine, arginine, and S-adenosylmethionine for the amino acid-stimulated mTORC1 pathway have been coming to light.	Arginine	38-46	CREB regulated transcription coactivator 1	Mus musculus	103-109
30698750-4	2019	Lys-SDE2Ct constitutes a short-lived physiological substrate of the Arg/N-end rule proteolytic pathway, in which UBR1 and UBR2 ubiquitin ligases mediate the degradation.	Arginine	68-71	ubiquitin protein ligase E3 component n-recognin 2	Homo sapiens	122-126
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 3 receptor	Homo sapiens	141-145
30722038-5	2019	Cancer-associated arginine mutations in the WD40 domain (R465H, R479Q and R505C) abolish both FBXW7 interaction with PAR and recruitment to DNA damage sites, causing inhibition of XRCC4 polyubiquitination and NHEJ.	Arginine	18-26	X-ray repair cross complementing 4	Homo sapiens	180-185
30954674-5	2019	While the number of newborn calretinin-positive neurons was greater in the sub-granular zone (SGZ) in 5-month old Arg-61 mice, this number dropped significantly in 10-month old Arg-61 mice to a lower level than in age-matched C57BL/6J mice.	Arginine	114-117	calbindin 2	Mus musculus	28-38
30366617-6	2018	Besides, 4b14 showed significant cell cycle arrest and apoptosis-inducing effects, as well as reduced the cellular symmetric arginine dimethylation level of SmD3 protein.	Arginine	125-133	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	157-161
30954674-7	2019	In conclusion, impaired cognitive functions in female Arg-61 apoE mice appear correlated with larger GCL volume and higher calretinin-positive cell number and suggest a compensatory cellular response that may be related to amyloid beta perturbations early in life.	Arginine	54-57	calbindin 2	Mus musculus	123-133
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	62-72	toll like receptor 4	Sus scrofa	277-281
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	62-72	MYD88 innate immune signal transduction adaptor	Sus scrofa	283-288
29082918-9	2018	Proteolytic removal of NH2- or COOH-terminal amino acids, citrullination of arginine residues by peptidyl arginine deiminases or nitration of tyrosine residues reduce CXCL12 activity.	Arginine	76-84	C-X-C motif chemokine ligand 12	Homo sapiens	167-173
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	62-72	C-X-C motif chemokine ligand 8	Sus scrofa	314-318
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	156-166	toll like receptor 4	Sus scrofa	277-281
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	156-166	MYD88 innate immune signal transduction adaptor	Sus scrofa	283-288
30979040-5	2019	However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-kappaBp65, and IL-8 transcripts.	Arginine	156-166	C-X-C motif chemokine ligand 8	Sus scrofa	314-318
31138989-6	2019	Mutagenesis-based structure-activity analysis revealed that positively charged arginine residue at 165 in TTYH1 and 164 in TTYH2 is critical for the formation of the channel-pore.	Arginine	79-87	tweety family member 1	Homo sapiens	106-111
29430837-0	2018	Architecture and hydration of the arginine-binding site of neuropilin-1.	Arginine	34-42	neuropilin 1	Homo sapiens	59-71
29430837-4	2018	Vascular endothelial growth factor (VEGF) binds to the b1 domain of NRP1 through interactions between the C-terminal arginine of VEGF and residues in the NRP1-binding site including Tyr297, Tyr353, Asp320, Ser346 and Thr349.	Arginine	117-125	neuropilin 1	Homo sapiens	68-72
30865893-8	2019	Instead, we found arginine serves as an effector for mTORC1 activation to promote cell growth in response to glutamine starvation.	Arginine	18-26	CREB regulated transcription coactivator 1	Mus musculus	53-59
30605863-6	2019	MDSCs deplete l-arginine due to a high expression of arginase 1 (ARG1) and their number increases 4-10 times depending on the type of the cancer.	Arginine	14-24	arginase 1	Homo sapiens	53-63
30605863-6	2019	MDSCs deplete l-arginine due to a high expression of arginase 1 (ARG1) and their number increases 4-10 times depending on the type of the cancer.	Arginine	14-24	arginase 1	Homo sapiens	65-69
30339823-2	2019	We report that GluK5 has two ER retention signals in its cytoplasmic C-terminus: an arginine-based signal and a di-leucine motif previously thought to be an endocytic motif.	Arginine	84-92	glutamate ionotropic receptor kainate type subunit 5	Homo sapiens	15-20
30562026-2	2019	NSC4056, the most potent inhibitor with an IC50 of 0.6 muM, which is also known as aurintricarboxylic acid, selectively binds to Arg and Tyr residues of CSE active site and preferably inhibits the CSE activity in cells rather than cystathionine beta-synthase (CBS), the other H2S-generating enzyme.	Arginine	129-132	cystathionine gamma-lyase	Rattus norvegicus	153-156
30318155-4	2019	FOXP3 undergoes methylation on arginine residues at positions 48 and 51 by interacting with protein arginine methyltransferase 1 (PRMT1).	Arginine	31-39	forkhead box P3	Homo sapiens	0-5
30448895-7	2019	Notably, the UTRs of HAstVs contain putative binding sites for the serine/arginine-rich factors SRSF2, SRSF5, SRSF6, SRSF3, and the multifunctional hnRNPE2 protein.	Arginine	74-82	serine and arginine rich splicing factor 2	Homo sapiens	96-101
30881620-3	2019	Our previous SAR studies of compounds, showing affinity for NRP-1, led us to develop branched peptides with general formula Lys(hArg)-AA2-AA3-Arg.	Arginine	129-132	neuropilin 1	Homo sapiens	60-65
30638448-6	2019	A mutagenesis screen of MICU1 identifies two highly-conserved Arg residues that might contact the DIME-Asp.	Arginine	62-65	mitochondrial calcium uptake 1	Homo sapiens	24-29
31395347-5	2019	An essential histone PTM involved in the DDR is histone methylation, which is regulated by histone methyltransferase (HMT) and histone demethylase (HDM) enzymes that add and remove methyl groups on lysine and arginine residues within proteins respectively.	Arginine	209-217	PR/SET domain 9	Homo sapiens	91-116
31395347-5	2019	An essential histone PTM involved in the DDR is histone methylation, which is regulated by histone methyltransferase (HMT) and histone demethylase (HDM) enzymes that add and remove methyl groups on lysine and arginine residues within proteins respectively.	Arginine	209-217	PR/SET domain 9	Homo sapiens	118-121
32124747-6	2019	The increased risk of influenza development is associated with the Asp/Gly genotype of TLR-4 (OR=4.22) and combination of mutant genotypes Leu/Phe and Phe/Phe of TLR-3 with Asp/Gly of TLR-4 and Arg/Gln of TLR-2 (OR=15.0); influenza-associated pneumonia - with genotype Phe/Phe of TLR-3 (OR=4.5).	Arginine	194-197	toll like receptor 3	Homo sapiens	162-167
30355733-2	2018	We have also reported that the C-terminal tail sequence beyond the C/EBPbeta leucine zipper is critical for its association with Spi1 via an exposed residue (Arg-232) located within a pocket at one end of the Spi1 DNA-recognition helix.	Arginine	158-161	CCAAT enhancer binding protein beta	Homo sapiens	67-76
30355733-3	2018	Here, combining in vitro interaction studies with computational docking and molecular dynamics of existing X-ray structures for the Spi1 and C/EBPbeta DBDs, along with the C/EBPbeta C-terminal tail sequence, we found that the tail sequence is intimately associated with Arg-232 of Spi1.	Arginine	270-273	CCAAT enhancer binding protein beta	Homo sapiens	141-150
30461258-0	2018	Investigation of Human Neutrophil Elastase Inhibition by Staphylococcus aureus EapH1: The Key Role Played by Arginine 89.	Arginine	109-117	elastase, neutrophil expressed	Homo sapiens	23-42
30559217-2	2018	Most KARs contain the subunit GluK2 (also known as GRIK2), and the properties of these receptors are determined in part by ADAR2 (also known as ADARB1)-mediated mRNA editing of GluK2, which changes a genomically encoded glutamine residue into an arginine residue (Q/R editing).	Arginine	246-254	adenosine deaminase RNA specific B1	Homo sapiens	123-128
28374859-1	2018	Arginase 1 (ARG1) and arginase 2 (ARG2) compete with nitric oxide synthases for the substrate l-arginine.	Arginine	94-104	arginase 1	Homo sapiens	0-10
28374859-1	2018	Arginase 1 (ARG1) and arginase 2 (ARG2) compete with nitric oxide synthases for the substrate l-arginine.	Arginine	94-104	arginase 1	Homo sapiens	12-16
29531043-1	2018	The Tudor domain-containing (Tdrd) family proteins play a critical role in transposon silencing in animal gonads by recognizing the symmetrically dimethylated arginine (sDMA) on the (G/A)R motif of the N-terminal of PIWI family proteins via the eTud domains.	Arginine	159-167	P-element induced wimpy testis	Drosophila melanogaster	216-220
29544440-3	2018	The aim of this study was to determine by which means the HIV-1 Env protein is transported to the cell surface although its transmembrane domain contains a conserved arginine residue.	Arginine	166-174	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	64-67
29544440-7	2018	A shortened version of the Env transmembrane domain causes arginine-dependent ER targeting.	Arginine	59-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	27-30
29559907-3	2018	recently reported that Arg1 (an anti-inflammatory gene that codes for arginase-1) is expressed in parts of the brain associated with amyloidosis prior to the onset of neuronal loss, suggesting that chronic brain arginine deprivation promotes AD-related neuropathology.	Arginine	212-220	arginase 1	Homo sapiens	23-27
29559907-3	2018	recently reported that Arg1 (an anti-inflammatory gene that codes for arginase-1) is expressed in parts of the brain associated with amyloidosis prior to the onset of neuronal loss, suggesting that chronic brain arginine deprivation promotes AD-related neuropathology.	Arginine	212-220	arginase 1	Homo sapiens	70-80
29580081-6	2018	The results showed that ARG and GAA supplements improved the feed conversion ratio (FCR) compared to the control (P &lt; 0.05).	Arginine	24-27	FCR	Gallus gallus	84-87
29580081-9	2018	A significant (P &lt; 0.05) decline in S-wave amplitude of the lead-II electrocardiogram, right to total ventricular weight ratio (RV:TV) and ascites mortality was observed by supplementing ARG or 1.5 g/kg GAA.	Arginine	190-193	alpha glucosidase 2	Gallus gallus	206-209
29447073-3	2018	Among the naturally occurring oligopeptides that were tested, Lys-Leu and Arg-Phe were Ptr2-specific substrates.	Arginine	74-77	Ptr2p	Saccharomyces cerevisiae S288C	87-91
28850807-1	2018	Milk-fat globule epidermal growth factor (EGF) 8 protein (MFGE8), also known as lactadherin, promotes cell adhesion in an Arg-Gly-Asp (RGD)-dependent modus via integrins.	Arginine	122-125	lactadherin	Equus caballus	58-63
30550787-4	2018	Mechanistically, LincGET physically binds to CARM1 and promotes the nuclear localization of CARM1, which can further increase the level of H3 methylation at Arginine 26 (H3R26me), activate ICM-specific gene expression, upregulate transposons, and increase global chromatin accessibility.	Arginine	157-165	coactivator-associated arginine methyltransferase 1	Mus musculus	45-50
30550787-4	2018	Mechanistically, LincGET physically binds to CARM1 and promotes the nuclear localization of CARM1, which can further increase the level of H3 methylation at Arginine 26 (H3R26me), activate ICM-specific gene expression, upregulate transposons, and increase global chromatin accessibility.	Arginine	157-165	coactivator-associated arginine methyltransferase 1	Mus musculus	92-97
30191331-9	2018	Liver beta-actin significantly increased with both Lys and Arg supplementation and muscle beta-actin significantly decreased (P &lt; 0.05) with &gt;= 1.5% supplemental Lys.	Arginine	59-62	actin, beta	Rattus norvegicus	6-16
30191331-10	2018	Kidney beta-actin significantly increased with Arg supplementation vs 3% Lys alone (P &lt; 0.05).	Arginine	47-50	actin, beta	Rattus norvegicus	7-17
30172814-5	2018	Also result of BET analysis showed chitosan, MFe3O4/CSNPs, and arginine-modified are nonporous and specific surface area for arginine-modified is more than chitosan, MFe3O4/CSNPs.	Arginine	63-71	delta/notch like EGF repeat containing	Homo sapiens	15-18
30172814-5	2018	Also result of BET analysis showed chitosan, MFe3O4/CSNPs, and arginine-modified are nonporous and specific surface area for arginine-modified is more than chitosan, MFe3O4/CSNPs.	Arginine	125-133	delta/notch like EGF repeat containing	Homo sapiens	15-18
30268610-9	2018	Supplementation of a complete mixture of essential AA or Arg, Val, Leu, His, Phe, Met, and Ile individually led to greater mTOR phosphorylation.	Arginine	57-60	mechanistic target of rapamycin kinase	Bos taurus	123-127
29930022-3	2018	METHODS: Targeted and untargeted metabolomics were used to investigate the effect of COX-2 deletion or inhibition in mice and in osteoarthritis patients exposed to nonsteroidal anti-inflammatory drugs on the l-arginine/nitric oxide pathway.	Arginine	208-218	cytochrome c oxidase II, mitochondrial	Mus musculus	85-90
30409181-6	2018	Arg residue at position P1 or P4 in furin cleavage sites significantly affect cleavage efficiency in P. pastoris.	Arginine	0-3	furin, paired basic amino acid cleaving enzyme	Homo sapiens	36-41
29804468-4	2018	Rev contains a nucleolar localization signal (NoLS) comprising the COOH terminus of the arginine-rich motif for accumulation within nucleoli-speculated as the interaction ground for Rev with cellular proteins mediating mRNA-independent nuclear export and splicing.	Arginine	88-96	Rev	Human immunodeficiency virus 1	0-3
29804468-4	2018	Rev contains a nucleolar localization signal (NoLS) comprising the COOH terminus of the arginine-rich motif for accumulation within nucleoli-speculated as the interaction ground for Rev with cellular proteins mediating mRNA-independent nuclear export and splicing.	Arginine	88-96	Rev	Human immunodeficiency virus 1	182-185
29804468-8	2018	Rev mutations missing single arginine residues remained strictly nucleolar in pattern and participated in proviral production, however, with reduced efficiency.	Arginine	29-37	Rev	Human immunodeficiency virus 1	0-3
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	164-231
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	233-243
30236872-7	2018	Finally, we showed that inhibition of Sirt1 expression by EX527 attenuated arginine-induced increase in the protein levels of phospho-AMPK and slow MyHC, the mRNA level of nitric oxide synthase (NOS) and the contents of NOS and NO, as well as decrease in fast MyHC protein level.	Arginine	75-83	nitric oxide synthase 1, neuronal	Mus musculus	172-193
30429607-8	2018	Serum proteomic analysis identified the arginine-degrading enzyme arginase I (ARG1) in the circulation of Atg7-deficient hosts, and in vivo arginine metabolic tracing demonstrated that serum arginine was degraded to ornithine.	Arginine	40-48	arginase, liver	Mus musculus	66-76
30429607-8	2018	Serum proteomic analysis identified the arginine-degrading enzyme arginase I (ARG1) in the circulation of Atg7-deficient hosts, and in vivo arginine metabolic tracing demonstrated that serum arginine was degraded to ornithine.	Arginine	40-48	arginase, liver	Mus musculus	78-82
30429607-11	2018	Deletion of Atg5 in the host similarly regulated [corrected] circulating arginine and suppressed tumorigenesis, which demonstrates that this phenotype is specific to autophagy function rather than to deletion of Atg7.	Arginine	73-81	autophagy related 5	Mus musculus	12-16
30056252-0	2018	Mineralocorticoid receptor blockade improves arginine transport and nitric oxide generation through modulation of cationic amino acid transporter-1 in endothelial cells.	Arginine	45-53	nuclear receptor subfamily 3 group C member 2	Homo sapiens	0-26
30056252-6	2018	Both Spironolactone and eplerenone significantly increased endothelial arginine transport, an effect which was further augmented by co-incubation with aldosterone, and blunted by either silencing of MCR or co-administration of amiloride.	Arginine	71-79	nuclear receptor subfamily 3 group C member 2	Homo sapiens	199-202
30358156-0	2018	L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.	Arginine	0-10	glucagon like peptide 1 receptor	Homo sapiens	46-51
30358156-2	2018	Previously, it has been shown that oral L-arginine acts as a GLP-1 secretagogue both in vitro and in vivo in rodents.	Arginine	40-50	glucagon like peptide 1 receptor	Homo sapiens	61-66
30358156-8	2018	RESULTS: At a dose of 17.1 mmol, L-arginine was well tolerated and stimulated the release of plasma GLP-1 (P &lt; 0.05) and PYY (P &lt; 0.001) following an ad libitum meal.	Arginine	33-43	glucagon like peptide 1 receptor	Homo sapiens	100-105
30358156-10	2018	CONCLUSIONS: L-arginine can significantly elevate GLP-1 and PYY in healthy human volunteers in combination with a meal.	Arginine	13-23	glucagon like peptide 1 receptor	Homo sapiens	50-55
30375398-7	2018	Further investigation revealed that PANDAR-reduced cisplatin sensitivity was likely or partly due to the PANDAR-binding protein SFRS2 (arginine/serine-rich 2), a splicing factor with the ability to negative regulate p53 and its phosphorylation at Serine 15 (Ser15).	Arginine	135-143	serine and arginine rich splicing factor 2	Homo sapiens	128-133
31458113-13	2018	A protein, RNase A, was also labeled with the reagent, and after click chemistry and biotin-avidin affinity chromatography, we identified two selective arginine residues.	Arginine	152-160	ribonuclease A family member 1, pancreatic	Homo sapiens	11-18
30393775-4	2018	Mechanistically, arginine starvation induces asparagine synthetase (ASNS), depleting these cancer cells of aspartate, and disrupting their malate-aspartate shuttle.	Arginine	17-25	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	45-66
30393775-4	2018	Mechanistically, arginine starvation induces asparagine synthetase (ASNS), depleting these cancer cells of aspartate, and disrupting their malate-aspartate shuttle.	Arginine	17-25	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	68-72
30393775-5	2018	Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS all protect the arginine-starved cells, establishing the causal effects of aspartate depletion and mitochondrial dysfunction on the arginine starvation-induced cell death.	Arginine	95-103	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	74-78
30206632-2	2018	Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation.	Arginine	153-163	arginase, liver	Mus musculus	0-16
30323330-4	2018	Despite having similar RBDs, the presence of an additional arginine, R52, confers Tat the ability to remodel the pseudo configuration, required for HEXIM binding, into a classical sandwich, thus displacing HEXIM.	Arginine	59-67	tyrosine aminotransferase	Homo sapiens	82-85
30294546-0	2018	The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.	Arginine	135-143	glucagon receptor	Homo sapiens	28-45
30294546-0	2018	The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.	Arginine	135-143	glucagon receptor	Homo sapiens	83-87
30568688-1	2018	It is well known that Arginine-Glycine-Aspartic acid (RGD) and Asparagine-Glycine-Arginine (NGR) peptides preferentially bind to integrin receptors and aminopeptidase N respectively and these two receptors play important roles in angiogenesis.	Arginine	22-30	alanyl aminopeptidase, membrane	Homo sapiens	152-168
30559217-2	2018	Most KARs contain the subunit GluK2 (also known as GRIK2), and the properties of these receptors are determined in part by ADAR2 (also known as ADARB1)-mediated mRNA editing of GluK2, which changes a genomically encoded glutamine residue into an arginine residue (Q/R editing).	Arginine	246-254	adenosine deaminase RNA specific B1	Homo sapiens	144-150
30172110-4	2018	As expected, the top two active hits (5 and 19) showed potent anti-proliferative activity against MV4-11 cells with EC50 values lower than 10 muM and reduced the cellular symmetric arginine dimethylation levels of SmD3 protein.	Arginine	181-189	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	214-218
30072381-7	2018	Lastly, we report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII.	Arginine	91-94	RRAD and GEM like GTPase 2	Homo sapiens	74-78
30072381-7	2018	Lastly, we report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII.	Arginine	91-94	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	154-160
30072381-7	2018	Lastly, we report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII.	Arginine	102-105	RRAD and GEM like GTPase 2	Homo sapiens	74-78
30072381-7	2018	Lastly, we report that substitution of two key amino acid residues in the Rem2 N terminus (Arg-79 and Arg-80) completely abolishes its ability to inhibit CaMKII.	Arginine	102-105	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	154-160
30184107-6	2018	10 and 11 to alanine had similar effect to the deletion mutant of Delta1-35, suggesting that these arginine play a role in the DNA helicase activity.	Arginine	99-107	helicase for meiosis 1	Homo sapiens	131-139
30456387-5	2018	Functional binding to the methyltransferase PRMT1 was promoted by continual arginine stretches, whereas interaction with the methyl-binding protein SMN1 was arginine content-dependent irrespective of linear position within the unstructured region.	Arginine	157-165	survival of motor neuron 1, telomeric	Homo sapiens	148-152
30358997-3	2018	We have designed 26RFa(20-26) analogues incorporating arginine derivatives modified by alkylated substituents.	Arginine	54-62	pyroglutamylated RFamide peptide	Homo sapiens	17-22
30181260-3	2018	The Ragulator complex tethers the Rag heterodimer to the lysosomal surface, and the SLC38A9 transmembrane protein is a lysosomal arginine sensor that upon activation stimulates mTORC1 activity through the Rag GTPases.	Arginine	129-137	CREB regulated transcription coactivator 1	Mus musculus	177-183
30181289-2	2018	We demonstrate that substituting H3G34 with arginine, valine, or aspartate (H3G34R/V/D), which converts the non-side chain glycine to a large side chain-containing residue, blocks H3 lysine 36 (H3K36) dimethylation and trimethylation by histone methyltransferases, including SETD2, an H3K36-specific trimethyltransferase.	Arginine	44-52	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	275-280
30358997-4	2018	We found that the Arg25 side chain length was necessary to retain the activity of 26RFa(20-26) and that N-monoalkylation of arginine was accommodated by the QRFPR active site.	Arginine	124-132	pyroglutamylated RFamide peptide receptor	Homo sapiens	157-162
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	glutathione-disulfide reductase	Homo sapiens	160-181
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	glutathione-disulfide reductase	Homo sapiens	183-185
30055993-2	2018	Arginase competes with nitric oxide synthase for substrate arginine to produce orthinine and urea.	Arginine	59-67	nitric oxide synthase 1, neuronal	Mus musculus	23-44
30358997-8	2018	Finally, N-methyl substituted arginine-containing peptides represent lead compounds for further development of QRFPR agonists.	Arginine	30-38	pyroglutamylated RFamide peptide receptor	Homo sapiens	111-116
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	37-47	nitric oxide synthase 1	Homo sapiens	93-105
30143685-0	2018	Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides.	Arginine	78-86	C9orf72-SMCR8 complex subunit	Homo sapiens	61-68
30143685-2	2018	On the other hand, disease-associated arginine-rich CPPs, such as poly-PR and poly-GR translated from C9orf72 gene, also efficiently enter neuronal cells and then kill them.	Arginine	38-46	C9orf72-SMCR8 complex subunit	Homo sapiens	102-109
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 1	Homo sapiens	93-105
30288342-2	2018	Here, we describe a spontaneous point mutation of cysteine to arginine (C14R) in the signal peptide of the NKp46 protein in congenic Ly5.1 mice and the newly generated NCRB6C14R strain.	Arginine	62-70	natural cytotoxicity triggering receptor 1	Mus musculus	107-112
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 1	Homo sapiens	107-111
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 1	Homo sapiens	115-119
30581791-2	2018	NO is synthesized enzymatically from l-arginine (l-Arg) by three NO synthase (NOS) isoforms, Neuronal NOS (nNOS or NOS1), Inducible NOS (iNOS or NOS2), and Endothelial NOS (eNOS or NOS3).	Arginine	49-54	nitric oxide synthase 1	Homo sapiens	181-185
30323341-0	2018	Arginine methylation controls the strength of gammac-family cytokine signaling in T cell maintenance.	Arginine	0-8	interleukin 2 receptor subunit gamma	Homo sapiens	46-52
29957475-1	2018	An activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates fibrinolysis by removing C-terminal lysine/arginine residues from partially degraded fibrin.	Arginine	119-127	carboxypeptidase B2	Homo sapiens	13-56
30323341-6	2018	Thus, arginine methylation regulates strength of signaling via gammac-family cytokines by facilitating the expression of signal-transducing components.	Arginine	6-14	interleukin 2 receptor subunit gamma	Homo sapiens	63-69
30012976-0	2018	Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.	Arginine	8-16	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	55-74
30056252-8	2018	The addition of tunicamycin (an inhibitor of protein glycosylation) or MCR silencing resulted in disappearance of the extra band and prevented the increase in arginine transport.	Arginine	159-167	nuclear receptor subfamily 3 group C member 2	Homo sapiens	71-74
30012976-1	2018	The influence of Arginine 117 of human cytochrome P450 2J2 in the recognition of ebastine and a series of terfenadone derivatives was studied by site-directed mutagenesis.	Arginine	17-25	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	39-58
30393775-5	2018	Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS all protect the arginine-starved cells, establishing the causal effects of aspartate depletion and mitochondrial dysfunction on the arginine starvation-induced cell death.	Arginine	211-219	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	74-78
30349045-5	2018	p62 is essential for mTORC1 activation in response to arginine, but it is not a direct sensor of free arginine in the mTORC1 pathway.	Arginine	54-62	CREB regulated transcription coactivator 1	Mus musculus	21-27
29754043-6	2018	The SSCP analyses revealed polymorphisms in the codons 6, 38, 43 and 48 of the PRNT coding region - respectively c.17C &gt; T (p.Ser6Phe, which disrupts a consensus arginine-X-X serine/threonine motif); c.112G &gt; C (p.Gly38 &gt; Arg); and synonymous c.129T &gt; C and c.144A &gt; G. The polymorphisms in codons 6, 38 and 48 occur simultaneously while the one in codon 43 occurs independently.	Arginine	231-234	prion protein (testis specific)	Ovis aries	79-83
30001605-1	2018	In this work the effect of ionic strength and arginine on the kinetics of aggregation of UV-irradiated muscle glycogen phosphorylase b (UV-Phb) was studied using dynamic light scattering at 37  C at various ionic strengths (0.02-0.7 M).	Arginine	46-54	prohibitin 1	Homo sapiens	139-142
29760200-7	2018	We show that arginines within a putative methylation motif in the third intracellular loop of SER-2 are methylated by PRMT5 in vitro Our data also suggest that this modification enhances SER-2 signaling in vivo to modulate animal behavior.	Arginine	13-22	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	118-123
30254218-4	2018	A1-mediated L-arginine depletion reduces nitric oxide (NO) formation by NOS leading to vascular dysfunction when endothelial NOS is involved but prevents inflammatory injury when inducible NOS is involved.	Arginine	12-22	arginase, liver	Mus musculus	0-2
30008699-1	2018	The broad-spectrum amino acid racemase (Alr) of Pseudomonas putida KT2440 preferentially interconverts the l- and d-stereoisomers of Lys and Arg.	Arginine	141-144	alanine racemase	Pseudomonas putida KT2440	40-43
30008699-12	2018	The metabolic profiles here also implicate Alr in catabolism of l-Arg, although the pathway by which d-Arg is further catabolized is not clear at this time.	Arginine	64-69	alanine racemase	Pseudomonas putida KT2440	43-46
30214242-1	2018	Background: Serine/arginine protein kinase 1 (SRPK1) is a protein kinase that belongs to the serine/arginine-rich domain family of splicing factors which are essential for splice-site selection, especially the modulation for RNA metabolism, localization, and translation.	Arginine	19-27	SRSF protein kinase 1	Homo sapiens	46-51
29701804-8	2018	The NO signal was slightly decreased by inhibitors of nitrate reductase but not by those of nitric oxide synthase, which could indicate a minor contribution of plant nitrate reductase and supports the existence of nitrate- and arginine-independent pathways for NO production.	Arginine	227-235	inducible nitrate reductase [NADH] 1	Glycine max	54-71
29701804-8	2018	The NO signal was slightly decreased by inhibitors of nitrate reductase but not by those of nitric oxide synthase, which could indicate a minor contribution of plant nitrate reductase and supports the existence of nitrate- and arginine-independent pathways for NO production.	Arginine	227-235	inducible nitrate reductase [NADH] 1	Glycine max	166-183
29483575-2	2018	Pentameric NPM1 undergoes liquid-liquid phase separation (LLPS) via heterotypic interactions with nucleolar components, including ribosomal RNA (rRNA) and proteins which display multivalent arginine-rich linear motifs (R-motifs), and is integral to the liquid-like nucleolar matrix.	Arginine	190-198	nucleophosmin 1	Homo sapiens	11-15
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Arginine	287-290	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	50-55
29459673-0	2018	Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.	Arginine	24-32	jumonji domain containing 7	Homo sapiens	71-76
29459673-1	2018	We have reported that JMJD5 and JMJD7 (JMJD5/7) are responsible for the clipping of arginine methylated histone tails to generate "tailless nucleosomes", which could release the pausing RNA polymerase II (Pol II) into productive transcription elongation.	Arginine	84-92	jumonji domain containing 7	Homo sapiens	32-37
29459673-1	2018	We have reported that JMJD5 and JMJD7 (JMJD5/7) are responsible for the clipping of arginine methylated histone tails to generate "tailless nucleosomes", which could release the pausing RNA polymerase II (Pol II) into productive transcription elongation.	Arginine	84-92	jumonji domain containing 7	Homo sapiens	39-46
29459673-2	2018	JMJD5/7 function as endopeptidases that cleave histone tails specifically adjacent to methylated arginine residues and continue to degrade N-terminal residues of histones via their aminopeptidase activity.	Arginine	97-105	jumonji domain containing 7	Homo sapiens	0-7
29718323-0	2018	PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.	Arginine	15-23	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	39-43
29718323-2	2018	Here we show that the protein arginine methyltransferase PRMT5 enhances the repair of Top1cc by direct binding to TDP1 and arginine dimethylation of TDP1 at residues R361 and R586.	Arginine	30-38	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	114-118
29718323-2	2018	Here we show that the protein arginine methyltransferase PRMT5 enhances the repair of Top1cc by direct binding to TDP1 and arginine dimethylation of TDP1 at residues R361 and R586.	Arginine	30-38	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	149-153
29718323-3	2018	Top1-induced replication-mediated DNA damage induces TDP1 arginine methylation, enhancing its 3"- phosphodiesterase activity.	Arginine	58-66	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	53-57
29718323-4	2018	TDP1 arginine methylation also increases XRCC1 association with TDP1 in response to CPT, and the recruitment of XRCC1 to Top1cc DNA damage foci.	Arginine	5-13	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
29718323-4	2018	TDP1 arginine methylation also increases XRCC1 association with TDP1 in response to CPT, and the recruitment of XRCC1 to Top1cc DNA damage foci.	Arginine	5-13	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	64-68
29784880-0	2018	Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.	Arginine	0-8	E1A binding protein p300	Homo sapiens	144-148
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	E1A binding protein p300	Homo sapiens	279-283
29922054-5	2018	With the expression of Arg-Gly-Asp peptide in the gelatin, the TGF-beta1@MAGNCs have an inherent affinity for chondrogenic ATDC5 cells.	Arginine	23-26	transforming growth factor, beta 1	Mus musculus	63-72
29784880-5	2018	This result indicated that arginine methylation of TLS abrogates both binding to pncRNA and TLS-mediated inhibition of CBP/p300 HAT activities.	Arginine	27-35	E1A binding protein p300	Homo sapiens	123-127
29784880-7	2018	Either methylation or mutation of Arg-476 of TLS significantly decreased pncRNA binding and thereby prevented a pncRNA-induced allosteric alteration in TLS that is required for its interaction with CBP/p300.	Arginine	34-37	E1A binding protein p300	Homo sapiens	202-206
29990354-7	2018	At T2, NF-kappaB p65 activation was positively related with arginine.	Arginine	60-68	RELA proto-oncogene, NF-kB subunit	Homo sapiens	17-20
29266319-2	2018	L-arginine can be metabolized by NO synthase (NOS) to form L-citrulline and NO, a potent vasodilator.	Arginine	0-10	nitric oxide synthase 1, neuronal	Mus musculus	33-44
29386386-3	2018	In a 13-year-old girl with syndromic neurodevelopmental disabilities, we identified a de novo mutation, RING1 p.R95Q, which alters a conserved arginine residue in the catalytic RING domain.	Arginine	143-151	ring finger protein 1	Homo sapiens	104-109
29990354-10	2018	CONCLUSIONS: This study for the first time provides data, at the plasma and PBMC level, supporting a proposed regulatory node of arginine and related amino acids, progesterone and NF-kappaB p65 at luteal phase of the menstrual cycle, aimed at successful preparation of pregnancy.	Arginine	129-137	RELA proto-oncogene, NF-kB subunit	Homo sapiens	190-193
29416041-2	2018	Arginine in particular is a major signalling molecule inside the cell, being a precursor for both l-ornithine and nitric oxide (NO) synthesis and a key regulator of the mTORC1 pathway.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	169-175
29872228-0	2018	Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state.	Arginine	21-29	solute carrier family 38 member 9	Danio rerio	58-65
30038627-1	2018	On murine T cells, GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) ADP-ribosylates the P2X7 ion channel at arginine 125 in response to nicotinamide adenine dinucleotide (NAD+) released during cell preparation.	Arginine	109-117	ADP-ribosyltransferase 2a	Mus musculus	60-65
29872228-2	2018	Here we present the first crystal structure of SLC38A9 from Danio rerio in complex with arginine.	Arginine	88-96	solute carrier family 38 member 9	Danio rerio	47-54
29425510-5	2018	Structure-function analyses revealed similar N-C interaction in TRPP2 as well as TRPM8/-V1/-C4 via highly conserved tryptophan and lysine/arginine residues.	Arginine	138-146	transient receptor potential cation channel subfamily M member 8	Homo sapiens	81-86
29743242-6	2018	Arginine triad substitutions that disrupted CDK9/CycT1 assembly accumulated Thr-186-dephosphorylated CDK9 associated with the cytoplasmic Hsp90/Cdc37 chaperone.	Arginine	0-8	cell division cycle 37, HSP90 cochaperone	Homo sapiens	144-149
29768197-2	2018	Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by nitric oxide synthase (NOS) isoforms.	Arginine	65-73	nitric oxide synthase 1, neuronal	Mus musculus	110-131
29092819-1	2018	Protein arginine methyltransferase 1 (PRMT1), PRMT4, and PRMT5 catalyze the methylation of arginine residues on target proteins.	Arginine	8-16	coactivator-associated arginine methyltransferase 1	Mus musculus	46-51
29953499-0	2018	Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-kappaB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.	Arginine	41-44	MALT1 paracaspase	Homo sapiens	32-37
29092819-1	2018	Protein arginine methyltransferase 1 (PRMT1), PRMT4, and PRMT5 catalyze the methylation of arginine residues on target proteins.	Arginine	8-16	protein arginine N-methyltransferase 5	Mus musculus	57-62
29685038-5	2018	In addition, arginine significantly increased the phospho-AMP-activated protein kinase (AMPK)/AMPK level (1.33 +- 0.06; p &lt; 0.05), the AMPK content (79.55 +- 0.13; p &lt; 0.001), and the AMPKalpha2 mRNA level (2.03 +- 0.20; p &lt; 0.01).	Arginine	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	50-86
29685038-5	2018	In addition, arginine significantly increased the phospho-AMP-activated protein kinase (AMPK)/AMPK level (1.33 +- 0.06; p &lt; 0.05), the AMPK content (79.55 +- 0.13; p &lt; 0.001), and the AMPKalpha2 mRNA level (2.03 +- 0.20; p &lt; 0.01).	Arginine	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	88-92
29685038-5	2018	In addition, arginine significantly increased the phospho-AMP-activated protein kinase (AMPK)/AMPK level (1.33 +- 0.06; p &lt; 0.05), the AMPK content (79.55 +- 0.13; p &lt; 0.001), and the AMPKalpha2 mRNA level (2.03 +- 0.20; p &lt; 0.01).	Arginine	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	94-98
29685038-5	2018	In addition, arginine significantly increased the phospho-AMP-activated protein kinase (AMPK)/AMPK level (1.33 +- 0.06; p &lt; 0.05), the AMPK content (79.55 +- 0.13; p &lt; 0.001), and the AMPKalpha2 mRNA level (2.03 +- 0.20; p &lt; 0.01).	Arginine	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	94-98
29685038-5	2018	In addition, arginine significantly increased the phospho-AMP-activated protein kinase (AMPK)/AMPK level (1.33 +- 0.06; p &lt; 0.05), the AMPK content (79.55 +- 0.13; p &lt; 0.001), and the AMPKalpha2 mRNA level (2.03 +- 0.20; p &lt; 0.01).	Arginine	13-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	190-200
29685038-6	2018	AMPKalpha2 silencing or AMPK inhibitor Compound C abolished arginine-induced upregulation of MyHC I.	Arginine	60-68	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-10
29685038-6	2018	AMPKalpha2 silencing or AMPK inhibitor Compound C abolished arginine-induced upregulation of MyHC I.	Arginine	60-68	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
29685038-7	2018	Our results provide, for the first time, evidence for the involvement of Akirin2 and the AMPK signaling pathway in arginine-induced MyHC I expression in porcine skeletal muscle satellite cells.	Arginine	115-123	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	89-93
29953499-4	2018	Cleavage occurred after Arginine 781 located in the C-terminus of MALT1.	Arginine	24-32	MALT1 paracaspase	Homo sapiens	66-71
29751762-3	2018	RESULTS: Here we show that various lysine and arginine mutations reduce the capacity of Tat to induce both transcription and mRNA splicing.	Arginine	46-54	tyrosine aminotransferase	Homo sapiens	88-91
29361115-6	2018	Nevertheless, surprisingly arginine methylation levels are increased when elt-2 is silenced, implying that erythroid-like transcription factor (ELT)-2 may also have ability to inhibit methyltransferase activity of PRMT-1.	Arginine	27-35	Transcription factor elt-2	Caenorhabditis elegans	74-79
29361115-6	2018	Nevertheless, surprisingly arginine methylation levels are increased when elt-2 is silenced, implying that erythroid-like transcription factor (ELT)-2 may also have ability to inhibit methyltransferase activity of PRMT-1.	Arginine	27-35	Transcription factor elt-2	Caenorhabditis elegans	107-150
29155213-11	2018	Inhibition of p44/42mapk, but not Akt reversed GDM-increased L-arginine uptake.	Arginine	61-71	interferon induced protein 44	Homo sapiens	14-17
29743532-7	2018	Sequence analysis of the nsd-1 gene from 13 resistant and 12 susceptible strains suggested that a specific arginine residue in the extracellular tail of the NSD-1 protein was common among susceptible strains.	Arginine	107-115	nuclear receptor binding SET domain protein 1	Homo sapiens	25-30
29227812-4	2018	In macrophages and myeloid derived suppressor cells (MDSCs) expression of Arg1 contributes to T-cell suppression and immune evasion by L-arginine depletion, in the setting of chronic inflammation and cancer.	Arginine	135-145	arginase 1	Homo sapiens	74-78
29361115-8	2018	Furthermore, we find that ELT-2 interferes with PRMT-1-induced arginine methylation in a dose-dependent manner.	Arginine	63-71	Transcription factor elt-2	Caenorhabditis elegans	26-31
29743532-7	2018	Sequence analysis of the nsd-1 gene from 13 resistant and 12 susceptible strains suggested that a specific arginine residue in the extracellular tail of the NSD-1 protein was common among susceptible strains.	Arginine	107-115	nuclear receptor binding SET domain protein 1	Homo sapiens	157-162
29743532-8	2018	Germline transformation of the susceptible-type nsd-1 (with a single nucleotide substitution) conferred partial susceptibility to resistant larvae, indicating that the +  nsd-1 gene is required for the susceptibility of B. mori larvae to BmDV and the susceptibility is solely a result of the substitution of a single amino acid with arginine.	Arginine	333-341	nuclear receptor binding SET domain protein 1	Homo sapiens	48-53
29121483-8	2018	High concentrations of NCG (1.0mM) and ARG (4.0mM) inhibited (P&lt;0.05) GnRH and nNOS mRNA abundance in GT1-7 cells.	Arginine	39-42	nitric oxide synthase 1, neuronal	Mus musculus	82-86
29409830-2	2018	Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of Fib-gammaD compared with control pancreata.	Arginine	70-80	fibrinogen alpha chain	Mus musculus	146-149
29274508-0	2018	A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40.	Arginine	32-40	chitinase 3 like 1	Homo sapiens	80-86
29274508-3	2018	YKL-40 harbors a consensus heparin-binding motif that consists of positively charged arginine (R) and lysine (K) (RRDK; residues 144-147); but they don"t bind to heparin.	Arginine	85-93	chitinase 3 like 1	Homo sapiens	0-6
29689199-0	2018	Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl.	Arginine	0-8	cordon-bleu WH2 repeat protein	Homo sapiens	76-80
29540477-4	2018	We show that CHCHD10 copurifies with cytochrome c oxidase (COX) and up-regulates COX activity by serving as a scaffolding protein required for MNRR1 phosphorylation, mediated by ARG (ABL proto-oncogene 2, nonreceptor tyrosine kinase (ABL2)).	Arginine	178-181	coiled-coil-helix-coiled-coil-helix domain containing 2	Homo sapiens	143-148
29689199-3	2018	Here we reveal that Cobl is controlled by arginine methylation.	Arginine	42-50	cordon-bleu WH2 repeat protein	Homo sapiens	20-24
29334179-5	2018	Using PEG2.4K -p(HEMASN38)3K as a model prodrug, herein an active-targeted strategy decorated with cys-arg-gly-asp-lys (CRGDK), a peptide specifically binds to neuropilin-1 overexpressed by tumor vessels and tumor cells, is successfully established to further improve the delivery and efficacy of SN38.	Arginine	67-70	neuropilin 1	Homo sapiens	160-172
29888319-2	2018	We have previously demonstrated that insertion of the internalizing Arginine-Glycine-Aspartic (iRGD) tumor-penetrating peptide at the C terminus of the fiber or transgenic expression of a secreted hyaluronidase can improve virus tumor targeting and spreading.	Arginine	68-76	interferon gamma inducible protein 47	Mus musculus	95-99
29126791-1	2018	The production of nitric oxide (NO) by nitric oxide synthases (NOS) depends on the bioavailability of L-arginine as NOS competes with arginase for this common substrate.	Arginine	102-112	nitric oxide synthase 1, neuronal	Mus musculus	39-61
29466666-3	2018	Here, we investigate RohP, a PLP-dependent enzyme that converts l-arginine to ( S)-4-hydroxy-2-ketoarginine.	Arginine	64-74	pyridoxal phosphatase	Homo sapiens	29-32
29128891-3	2018	Moreover, protein arginine methyltransferase (PRMT)1-dependent arginine modification of forkhead box other (FoxO)1 protein interferes with Akt-dependent phosphorylation.	Arginine	18-26	protein arginine methyltransferase 1	Rattus norvegicus	46-52
29128891-3	2018	Moreover, protein arginine methyltransferase (PRMT)1-dependent arginine modification of forkhead box other (FoxO)1 protein interferes with Akt-dependent phosphorylation.	Arginine	18-26	forkhead box O1	Rattus norvegicus	108-114
29397169-8	2018	When Arg was infused with nor-NOHA, the activity of total arginase, ornithine decarboxylase, and nitric oxide synthase, and the concentration of casein, protein, and fat in milk did not change compared with the nor-NOHA group, but the milk protein yield, the expression of some Arg transporters (SLC7A5 and SLC7A8), and milk yield increased.	Arginine	5-8	solute carrier family 7 member 8	Bos taurus	307-313
29226865-8	2018	Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion.	Arginine	36-44	serine and arginine rich splicing factor 2	Homo sapiens	65-69
29466666-7	2018	Together with our earlier studies on an O2, PLP-dependent l-arginine oxidase, our work suggests that there is a shared pathway leading to both oxidized and hydroxylated products from l-arginine.	Arginine	58-68	pyridoxal phosphatase	Homo sapiens	44-47
29134727-9	2018	Using a heterologous dual expression vector, we reveal for the first time that a Buchnera antisense sRNA can post-transcriptionally interact with its cognate Buchnera coding sequence, carB, a gene involved in arginine biosynthesis.	Arginine	209-217	syntaxin 8	Homo sapiens	184-188
29449376-2	2018	SseK3 is a glycosyltransferase that transfers an N-acetylglucosamine (GlcNAc) moiety onto the guanidino group of a target arginine, modulating host cell function.	Arginine	122-130	glycosyl transferase	Escherichia coli	11-30
29430837-6	2018	We observed side chain flexibility for Tyr297 and Asp320 in the six new high-resolution crystal structures of arginine analogues bound to NRP1.	Arginine	110-118	neuropilin 1	Homo sapiens	138-142
29080161-5	2018	We describe the methodology employed for the determination of ODC and ADC activities in plant tissues by detecting the release of (C14) CO2 using (C14) labelled substrates (ornithine or arginine).	Arginine	186-194	ornithine decarboxylase 1	Homo sapiens	62-65
29430837-10	2018	Our report provides a comprehensive description of the binding site for the peptidic ligands" C-terminal arginines in the b1 domain of NRP1, highlights the importance of conserved structural waters in drug design and validates the utility of the computational hydration map prediction method in the context of neuropilin.	Arginine	105-114	neuropilin 1	Homo sapiens	135-139
29409673-11	2018	Our data not only illustrate the important roles of OGG1 in histone modification, but also reveal the mechanism by which OGG1 affects PRMT5 binding on H4R3 resulting in the symmetrical dimethylation of histone H4 arginine-3.	Arginine	213-221	protein arginine N-methyltransferase 5	Mus musculus	134-139
29162499-4	2018	Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP).	Arginine	45-55	amine oxidase, copper containing 1	Rattus norvegicus	171-186
29588400-5	2018	Mutation of surface-exposed acidic thumb domain residues D250, E297, E298, and E300 to arginine resulted in various levels of impairment of the interaction between RT and eEF1A.	Arginine	87-95	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	171-176
28609431-8	2018	There was no difference in the arginine or citrulline levels between the two groups.ConclusionsThis study suggests an association (P&lt;0.05) between SNPs in CPS1 and PPHN.	Arginine	31-39	carbamoyl-phosphate synthase 1	Homo sapiens	158-162
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	55-58	RELA proto-oncogene, NF-kB subunit	Homo sapiens	193-196
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	RELA proto-oncogene, NF-kB subunit	Homo sapiens	193-196
29368397-5	2018	Whole muscle analyses (the first experiment) revealed that ARG attenuated ECC-induced force deficit and autolysis of calpain-1, and increased the amounts of S-nitrosylated calpain-1.	Arginine	59-62	calpain 1	Rattus norvegicus	117-126
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-58
29368397-5	2018	Whole muscle analyses (the first experiment) revealed that ARG attenuated ECC-induced force deficit and autolysis of calpain-1, and increased the amounts of S-nitrosylated calpain-1.	Arginine	59-62	calpain 1	Rattus norvegicus	172-181
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	RELA proto-oncogene, NF-kB subunit	Homo sapiens	221-224
29368397-6	2018	Regarding ryanodine receptor (RyR) and dihydropyridine receptor (DHPR), ECC-induced proteolysis was completely inhibited by ARG, whereas the inhibition was partial for junctophilin-1 (JP1).	Arginine	124-127	ryanodine receptor 2	Rattus norvegicus	30-33
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	RELA proto-oncogene, NF-kB subunit	Homo sapiens	221-224
29159695-3	2018	Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel).	Arginine	123-131	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	84-87
29800597-7	2018	Nut components, such as unsaturated fatty acids, l-arginine, beneficial minerals, phenolic compounds and phytosterols, appear to be of paramount importance for their health effects.	Arginine	49-59	NUT midline carcinoma family member 1	Homo sapiens	0-3
29159695-3	2018	Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel).	Arginine	123-131	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	177-180
29159695-3	2018	Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel).	Arginine	173-176	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	84-87
28803402-6	2018	The inhibition of actin dynamics by treatment with latrunculin B or jasplakinolide and the disruption of the adhesion between the PM and the CW by treatment with RGDS peptide (Arg-Gly-Asp-Ser) enhanced guard cell plasmolysis.	Arginine	176-179	ral guanine nucleotide dissociation stimulator	Homo sapiens	162-166
29159695-3	2018	Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel).	Arginine	173-176	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	177-180
29159695-4	2018	The effect of pH on the amount of arginine attached on Lig-NF surface was evaluated at three different pH values-5, 6, and 7.	Arginine	34-42	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	55-58
29159695-5	2018	Fourier transform infrared spectroscopy and zeta potential of Lig-NFs before and after surface modification confirmed the surface modification of Lig-NFs with arginine molecules.	Arginine	159-167	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	62-65
28986506-4	2018	Furthermore, methylation of arginines in the RGG domain abolishes the protein-protein interaction and the inhibitory effect of Sbp1 on translation initiation of Pab1 mRNA.	Arginine	28-37	high mobility group box 1	Homo sapiens	127-131
29159695-5	2018	Fourier transform infrared spectroscopy and zeta potential of Lig-NFs before and after surface modification confirmed the surface modification of Lig-NFs with arginine molecules.	Arginine	159-167	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	146-149
29159695-6	2018	The optimum gel composed of uniform Arg-Lig-NFs with diameter ranging from 100 to 250 nm.	Arginine	36-39	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	40-43
29159695-8	2018	The release of arginine from Arg-Lig-NF gel showed a sustained release manner, and about 86.28 +- 3.50% of attached arginine were released after 24 h. Moreover, the optimum gel presented suitable viscosity and spreadability for topical application.	Arginine	15-23	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	33-36
29159695-8	2018	The release of arginine from Arg-Lig-NF gel showed a sustained release manner, and about 86.28 +- 3.50% of attached arginine were released after 24 h. Moreover, the optimum gel presented suitable viscosity and spreadability for topical application.	Arginine	29-32	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	33-36
29159695-8	2018	The release of arginine from Arg-Lig-NF gel showed a sustained release manner, and about 86.28 +- 3.50% of attached arginine were released after 24 h. Moreover, the optimum gel presented suitable viscosity and spreadability for topical application.	Arginine	116-124	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	33-36
29159695-9	2018	The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution.	Arginine	97-100	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	101-104
29254508-2	2017	Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-arginine, a nutrient required for T cell and natural killer (NK) cell proliferation.	Arginine	126-136	arginase 1	Homo sapiens	25-35
29159695-9	2018	The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution.	Arginine	97-100	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	235-238
29254508-2	2017	Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-arginine, a nutrient required for T cell and natural killer (NK) cell proliferation.	Arginine	126-136	arginase 1	Homo sapiens	37-41
29159695-9	2018	The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution.	Arginine	97-100	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	235-238
29159695-9	2018	The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution.	Arginine	231-234	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	101-104
29159695-9	2018	The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution.	Arginine	288-296	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	101-104
29159695-10	2018	Overall, these findings demonstrate that Arg-Lig-NF gel can be a promising material for the future development of effective hydrocolloid wound dressings used in the treatment of acute and chronic wounds.	Arginine	41-44	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	45-48
29215019-0	2017	ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36.	Arginine	48-56	response regulator transcription factor	Streptococcus sanguinis SK36	0-4
28447340-5	2018	Although average daily feed intake (ADFI) was not influenced by dietary treatments, increasing Arg up to 100% of NRC recommendations improved (p &lt; .05) feed conversion ratio (FCR) throughout the trial period.	Arginine	95-98	FCR	Gallus gallus	178-181
29215019-8	2017	We conclude that by promoting the expression of arginine biosynthetic genes, especially argB gene, the ciaR mutation reduced polysaccharide production, resulting in the formation of a fragile biofilm in Streptococcus sanguinis.	Arginine	48-56	acetylglutamate kinase	Streptococcus sanguinis SK36	88-92
29215019-8	2017	We conclude that by promoting the expression of arginine biosynthetic genes, especially argB gene, the ciaR mutation reduced polysaccharide production, resulting in the formation of a fragile biofilm in Streptococcus sanguinis.	Arginine	48-56	response regulator transcription factor	Streptococcus sanguinis SK36	103-107
29276085-6	2018	Importantly, the CFIm activator functions are mediated by the arginine-serine repeat (RS) domains of CFIm68/59, which bind specifically to an RS-like region in the CPSF subunit Fip1, and this interaction is inhibited by CFIm68/59 hyper-phosphorylation.	Arginine	62-70	factor interacting with PAPOLA and CPSF1	Homo sapiens	177-181
28834219-3	2017	HLA-DQA1 positive for Arginine at position 52 (Arg52) (OR = 15.2) and HLA-DQB1 negative for Aspartic acid at the position 57 (Asp57) (OR = 9.0) alleles appear to be important genetic markers for T1D susceptibility, with higher odds ratio values than any single allele and than most of the haplotypes.	Arginine	22-30	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-8
28987626-3	2018	The results showed that ghrelin significantly inhibited the voltage-dependent K+ currents in hippocampal cells, and the inhibitory effect was more significant when l-arginine was co-administered.	Arginine	164-174	ghrelin and obestatin prepropeptide	Rattus norvegicus	24-31
27822979-4	2017	Our results indicate that all the 12 hits showed good CNS drug-like properties, have better binding free energy and ADME profile as compared to co-crystallized ligand with the best ligand hit retaining conserved hydrogen bond interactions with Ala-166, Thr-168, Ser-145, and Arg-61 residues in bilobatevenus fly-trap domain of mGluR2 receptor.	Arginine	275-278	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	327-333
29479880-6	2018	Furthermore, we found a mutation on exon 3 of the HPRT gene in the patient and his mother (exon 3: c.143G&gt;A), which resulted in arginine to histidine (p.R48H) substitution in the encoded protein.	Arginine	131-139	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	50-54
29450408-3	2018	In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nomega-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice.	Arginine	31-39	arginase, liver	Mus musculus	93-103
29450408-3	2018	In this report, we blocked the arginine-ornithine metabolic pathway by inhibiting the enzyme arginase-1 with Nomega-hydroxy-nor-arginine (nor-NOHA) to make arginine more available to the alternate citrulline pathway for augmented NO production and increased incidence of autoimmune T1D in female non-obese diabetic (NOD) mice.	Arginine	128-136	arginase, liver	Mus musculus	93-103
28642594-6	2018	All GATA2 mutants, except for sL359V, displayed reduced DNA-binding affinity and transactivation compared with wild type (WT), which could be attributed to mutations of arginines critical for DNA binding or amino acids required for ZF2 domain structural integrity.	Arginine	169-178	GATA binding protein 2	Homo sapiens	4-9
29077951-7	2018	Meanwhile, IOF of Arg enhanced the hepatic glucose-6-phosphatase (G6P) activity at hatch (P &lt; 0.05).	Arginine	18-21	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	43-64
29077951-7	2018	Meanwhile, IOF of Arg enhanced the hepatic glucose-6-phosphatase (G6P) activity at hatch (P &lt; 0.05).	Arginine	18-21	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	66-69
29399404-1	2018	The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu.	Arginine	50-58	arginase 1	Homo sapiens	11-21
29188620-9	2017	In addition, the proband was detected to have carried c.211C&gt;T (p.R71X) of the HFE gene, which resulted in substitution of arginine by a stop codon.	Arginine	126-134	homeostatic iron regulator	Homo sapiens	82-85
28299479-6	2017	We found that dietary Gln or Arg supplementation decreased bacterial colonization and promoted the activation of innate immunity (e.g., the mRNA expression of pIgR, CRS1C, and Reg3gamma) in the intestine of ETEC-infected mice.	Arginine	29-32	polymeric immunoglobulin receptor	Mus musculus	159-163
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	ribosomal protein S6	Homo sapiens	285-305
28299479-6	2017	We found that dietary Gln or Arg supplementation decreased bacterial colonization and promoted the activation of innate immunity (e.g., the mRNA expression of pIgR, CRS1C, and Reg3gamma) in the intestine of ETEC-infected mice.	Arginine	29-32	regenerating islet-derived 3 gamma	Mus musculus	176-185
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	ribosomal protein S6	Homo sapiens	307-311
29196683-0	2017	Preferential selection of Arginine at the lipid-water-interface of TRPV1 during vertebrate evolution correlates with its snorkeling behaviour and cholesterol interaction.	Arginine	26-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
29568320-3	2018	The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein.	Arginine	28-36	cyclin D1	Homo sapiens	230-239
28820066-12	2017	Exceptionally several Arg residues from MT_IL27 appeared to play a major role, thereby stabilizing the simulated MT_IL27-gp130 complexes.	Arginine	22-25	interleukin 27	Homo sapiens	43-47
29175682-0	2018	Expression of progesterone receptor protein in the ovine uterus during the estrous cycle: Effects of nutrition, arginine and FSH.	Arginine	112-120	progesterone receptor	Ovis aries	14-35
28820066-12	2017	Exceptionally several Arg residues from MT_IL27 appeared to play a major role, thereby stabilizing the simulated MT_IL27-gp130 complexes.	Arginine	22-25	interleukin 27	Homo sapiens	116-120
29487337-3	2018	A novel UPLC-MS method, measuring the conversion of ARG to ornithine (ORN), was developed to determine arginase 1 and arginase 2 inhibition by HOMOARG, lysine (LYS), proline (PRO), agmatine (AG), asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and NG-Monomethyl-L-arginine (L-NMMA).	Arginine	52-55	arginase 1	Homo sapiens	103-113
29099056-1	2017	Previously we had shown that ammonia stimulates nitric oxide (NO) synthesis in astrocytes by increasing the uptake of the precursor amino acid, arginine via the heteromeric arginine/glutamine transporter y+LAT2.	Arginine	144-152	linker for activation of T cells family, member 2	Rattus norvegicus	206-210
29098611-9	2018	Furthermore, hepatic arginase I levels positively correlated with plasma arginase I levels and negatively correlated with L-arginine bioavailability in plasma.	Arginine	122-132	arginase, liver	Mus musculus	21-31
29099056-8	2017	Moreover, the y+LAT2-dependent component of ammonia-evoked arginine uptake in astrocytes was reduced in the presence of ADMA in the medium.	Arginine	59-67	linker for activation of T cells family, member 2	Rattus norvegicus	16-20
29080813-7	2018	Liver-specific toll-like receptor (TLR4) knockout mice were utilized to clarify the role of TLR4 in Arg-induced IGF-I expression and secretion.	Arginine	100-103	insulin-like growth factor 1	Mus musculus	112-117
28964831-9	2017	Based on sequence and structural analyses, we predicted the significance of targeting human APN residues: Ala-351, Arg-442, Ala-474, Phe-896 and Asn-900 for improving the selectivity of the identified compounds.	Arginine	115-118	alanyl aminopeptidase, membrane	Homo sapiens	92-95
29080813-12	2018	Arg not only significantly increased IGF-1 expression and secretion under acute fasting and chronic CR conditions but also attenuated body weight loss.	Arginine	0-3	insulin-like growth factor 1	Mus musculus	37-42
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	Arginine	98-101	amine oxidase copper containing 3	Homo sapiens	17-22
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	Arginine	98-101	amine oxidase copper containing 3	Homo sapiens	135-140
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	117-122	transcobalamin 2	Homo sapiens	270-273
28860188-8	2017	The molecular basis for this activity was characterized as an interaction of JNJ0966 with a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106, which is distinct from the catalytic domain.	Arginine	163-166	matrix metallopeptidase 9	Mus musculus	130-135
29111742-1	2018	Citrullination of arginine residues is a post-translational modification (PTM) found on myelin basic protein (MBP), which neutralizes MBPs positive charge, and is implicated in myelin damage and multiple sclerosis (MS).	Arginine	18-26	myelin basic protein	Mus musculus	88-108
29111742-1	2018	Citrullination of arginine residues is a post-translational modification (PTM) found on myelin basic protein (MBP), which neutralizes MBPs positive charge, and is implicated in myelin damage and multiple sclerosis (MS).	Arginine	18-26	myelin basic protein	Mus musculus	110-113
29111742-3	2018	We quantify changes in lysine and arginine PTMs on MBP derived from mice induced with an experimental autoimmune encephalomyelitis (EAE) model of MS using liquid chromatography tandem mass spectrometry.	Arginine	34-42	myelin basic protein	Mus musculus	51-54
29191653-10	2018	Part of these CDR-H3s contain arginine(s) in the middle of the CDR-H3 loop in lambda5-/- mice, whereas few arginine(s) exist in this middle loop in WT CDR-H3s in the absence of clonal expansion.	Arginine	30-38	immunoglobulin lambda-like polypeptide 1	Mus musculus	78-85
29191653-11	2018	This CDR-H3 feature in lambda5-/- mice presumably reflects the role of the pre-BCR in autoantibody regulation, since arginine(s) are often found in the antigen-binding site of autoantibodies.	Arginine	117-125	immunoglobulin lambda-like polypeptide 1	Mus musculus	23-30
28852826-1	2017	INTRODUCTION: In chronic obstructive pulmonary disease (COPD), there is an activation of the L-arginine nitric oxide pathway.	Arginine	93-103	COPD	Homo sapiens	56-60
29073066-5	2017	Further studies revealed the TRAF4-binding motif Arg-Leu-X-Ala.	Arginine	49-52	TNF receptor associated factor 4	Homo sapiens	29-34
29028548-1	2018	Arginine and alpha-tocopherol succinate (alpha-TOS) double grafted N-trimethyl chitosan chloride (TMC) nanoparticles (TAS NPs) were designed and developed for effective co-delivery of doxorubicin (DOX) and Survivin shRNA-expressing pDNA (iSur-pDNA).	Arginine	0-8	baculoviral IAP repeat-containing 5	Mus musculus	206-214
28842250-4	2017	RAP80 directly binds the internal region of p32 through its arginine rich C-terminal domain.	Arginine	60-68	inhibitor of growth family member 2	Homo sapiens	44-47
30097878-1	2018	Mouse T cells express the toxin-related ecto-ADP-ribosyltransferase ARTC2 that catalyzes the posttranslational ADP-ribosylation of cell surface proteins by transferring the ADP-ribose group of its substrate nicotinamide adenine dinucleotide (NAD+) to arginine residues of its target proteins.	Arginine	251-259	ADP-ribosyltransferase 2a	Mus musculus	68-73
28868581-4	2017	Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons.	Arginine	79-89	nitric oxide synthase 1	Homo sapiens	108-112
29053970-4	2017	SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins.	Arginine	38-46	CREB regulated transcription coactivator 1	Mus musculus	139-145
29094484-0	2017	Degradation of AMPK-alpha1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation.	Arginine	81-89	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	15-26
29094484-6	2017	These BR cells also showed a metabolic shift from glucose to arginine dependence, which was supported by decreased expressions of GLUT1 (glucose transporter) and hexokinase II (HKII) coupled with less glucose uptake but high levels of arginine transporter CAT-2 expression.	Arginine	61-69	hexokinase 2	Homo sapiens	162-175
29094484-6	2017	These BR cells also showed a metabolic shift from glucose to arginine dependence, which was supported by decreased expressions of GLUT1 (glucose transporter) and hexokinase II (HKII) coupled with less glucose uptake but high levels of arginine transporter CAT-2 expression.	Arginine	61-69	hexokinase 2	Homo sapiens	177-181
29094484-6	2017	These BR cells also showed a metabolic shift from glucose to arginine dependence, which was supported by decreased expressions of GLUT1 (glucose transporter) and hexokinase II (HKII) coupled with less glucose uptake but high levels of arginine transporter CAT-2 expression.	Arginine	61-69	solute carrier family 7 member 2	Homo sapiens	256-261
29115630-7	2018	TIPE2 overexpression accelerated IL-4 induced M2 polarization by dampening mTORC1 activation via the accelerated process of arginine to urea.	Arginine	124-132	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	0-5
29053970-7	2017	Thus, through SLC38A9, arginine serves as a lysosomal messenger that couples mTORC1 activation to the release from lysosomes of the essential amino acids needed to drive cell growth.	Arginine	23-31	CREB regulated transcription coactivator 1	Mus musculus	77-83
28579117-2	2017	The core sequence of NDP-alpha-MSH, His-Phe-Arg-Trp, is important for ligand binding and biological activities at the melanocortin receptor subtypes (MCRs).	Arginine	44-47	norrin cystine knot growth factor NDP	Homo sapiens	21-24
30064337-2	2018	The mRNAs encoding the ubiquitously expressed actin-crosslinking proteins Filamin A and Filamin B undergo RNA editing leading to a highly conserved glutamine to arginine exchange at the identical position in either protein.	Arginine	161-169	filamin, alpha	Mus musculus	74-83
29183288-11	2017	CONCLUSION: Complete ablation of Arg1 in the lung affects mRNA abundance of arginine-transporting and -metabolizing genes, and pro-inflammatory genes, but not methacholine responsiveness or accumulation of inflammatory cells.	Arginine	76-84	arginase, liver	Mus musculus	33-37
29226078-5	2017	Using a biochemical approach, we initially purified a putative chicken PRMT4 protein and thus provided the first evidence for the presence of an endogenous PRMT4-specific enzymatic activity toward histone H3 arginine 17 (H3R17) in avian cells.	Arginine	208-216	coactivator-associated arginine methyltransferase 1	Mus musculus	71-76
28708224-2	2017	CASE REPORT: We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet.	Arginine	124-132	ornithine aminotransferase	Homo sapiens	57-61
29274231-5	2017	In addition to zinc finger domains in CPSF30, we identify using quantitative RNA-binding assays an N-terminal lysine/arginine-rich motif in WDR33 as a critical determinant of specific AAUAAA motif recognition.	Arginine	117-125	WD repeat domain 33	Homo sapiens	140-145
29226078-5	2017	Using a biochemical approach, we initially purified a putative chicken PRMT4 protein and thus provided the first evidence for the presence of an endogenous PRMT4-specific enzymatic activity toward histone H3 arginine 17 (H3R17) in avian cells.	Arginine	208-216	coactivator-associated arginine methyltransferase 1	Mus musculus	156-161
29292255-5	2017	RESULTS: Among the 9 protein arginine methylation enzyme family genes that were tissue?specifically expressed in the DRG, Prmt2 and Prmt3 showed the highest and Prmt6 showed the lowest basal expression.	Arginine	29-37	protein arginine N-methyltransferase 2	Mus musculus	122-127
28757124-6	2017	As for all Kir channels, a cluster of basic residues is present in the N-terminal domain of Kir6.2 and is composed of 5 arginines which are proximal to the GPCR C-ter in the fusion proteins.	Arginine	120-129	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	11-14
29107294-7	2017	Tanycytes from mice lacking the Tas1r1 gene had diminished responses to lysine and arginine but not alanine.	Arginine	83-91	taste receptor, type 1, member 1	Mus musculus	32-38
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	105-115	transcobalamin 2	Homo sapiens	270-273
28711961-3	2017	In the present study, we sought to evaluate whether the cytoprotective effects of L-arginine in neonatal obstructive nephropathy may be associated with NO-dependent increases in WT-1 and Hsp70 expression.	Arginine	82-92	WT1 transcription factor	Rattus norvegicus	178-182
28515388-1	2017	Nitric oxide (NO), generated from L-arginine by three different isoforms of nitric oxide synthase (NOS), is a pleiotropic factor to regulate physiological functions in almost every organ and tissue.	Arginine	34-44	nitric oxide synthase 1, neuronal	Mus musculus	76-97
28893906-7	2017	On the basis of a homology model of the 35-amino acid NTR of MYO1C35 (NTR35) docked to the X-ray structure of MYO1CC, we predicted that MYO1C35 NTR residue Arg-21 would engage in a specific interaction with post-relay helix residue Glu-469, which affects the mechanics of the myosin power stroke.	Arginine	156-159	neurotensin receptor 1	Homo sapiens	54-57
28893906-7	2017	On the basis of a homology model of the 35-amino acid NTR of MYO1C35 (NTR35) docked to the X-ray structure of MYO1CC, we predicted that MYO1C35 NTR residue Arg-21 would engage in a specific interaction with post-relay helix residue Glu-469, which affects the mechanics of the myosin power stroke.	Arginine	156-159	neurotensin receptor 1	Homo sapiens	70-73
29233899-0	2017	Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility.	Arginine	65-73	guanylate binding protein 1	Homo sapiens	83-87
29233899-4	2017	The targeting of GBP1 to cytosolic bacteria, via a unique triple-arginine motif present in its C terminus, promotes the corecruitment of four additional GBP paralogs (GBP2, GBP3, GBP4, and GBP6).	Arginine	65-73	guanylate binding protein 1	Homo sapiens	17-21
30263714-0	2017	Effects of l-arginine on growth hormone and insulin-like growth factor 1.	Arginine	11-21	gonadotropin releasing hormone receptor	Rattus norvegicus	25-39
30263714-2	2017	In this study, the effects of l-arginine on the expression of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), the two key growth factors, are investigated in cultured GH3 pituitary epithelium and HepG2 cells, respectively.	Arginine	30-40	gonadotropin releasing hormone receptor	Rattus norvegicus	62-76
28846111-6	2017	Mutation of both lysine residues to arginine (R) abolished t-HO-1-enhanced tumor cell growth, migration and invasion.	Arginine	36-44	THO complex 1	Homo sapiens	59-65
28711961-8	2017	L-arginine treatment increased NO levels, reduced apoptosis and restored expression levels of WT-1 and Hsp70 to control levels.	Arginine	0-10	WT1 transcription factor	Rattus norvegicus	94-98
28711961-11	2017	CONCLUSIONS: L-arginine treatment in experimental neonatal UUO reduces apoptosis coincident with restoration of WT-1 and Hsp70 expression levels and directly inhibits mechanical strain-induced apoptosis in an NO-dependent manner in vitro.	Arginine	13-23	WT1 transcription factor	Rattus norvegicus	112-116
28711961-12	2017	This potentially implicates an NO-Hsp70-WT-1 axis in the cytoprotective effects of L-arginine.	Arginine	83-93	WT1 transcription factor	Rattus norvegicus	40-44
29110610-4	2017	Arginase 1 (Arg-1) plays a critical role in coordinating the immune response by regulating availability of arginine.	Arginine	107-115	arginase 1	Homo sapiens	0-10
29296509-4	2017	Multiple studies have focused on how leucine and arginine activate mTORC1 through the Rag GTPases, with mechanistic details slowly emerging.	Arginine	49-57	CREB regulated transcription coactivator 1	Mus musculus	67-73
29110610-4	2017	Arginase 1 (Arg-1) plays a critical role in coordinating the immune response by regulating availability of arginine.	Arginine	107-115	arginase 1	Homo sapiens	12-17
29053970-2	2017	Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters.	Arginine	24-32	CREB regulated transcription coactivator 1	Mus musculus	14-20
29053970-3	2017	Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis.	Arginine	37-45	CREB regulated transcription coactivator 1	Mus musculus	61-67
28992603-4	2017	Moreover, two SNPs (CYP17 -34 T:C (MSP AI) and CYP19 T:C (Trp:Arg)) of cytochrome P450, which is involved in steroid metabolism pathways, were analysed between the groups.	Arginine	62-65	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	20-25
28801461-10	2017	Third, an Arg-Asp dipeptide immediately preceding the ZF helix, conserved in two PRDM9a fingers and three PRDM9c fingers, permits adaptability to variations from a C:G base pair (G-Arg interaction) to a G:C base pair (C-Asp interaction).	Arginine	10-13	PR/SET domain 9	Homo sapiens	81-86
28987382-1	2017	Arginine methylation is carried out by protein arginine methyltransferase (PRMTs) family.	Arginine	0-8	coactivator-associated arginine methyltransferase 1	Mus musculus	39-73
28987382-1	2017	Arginine methylation is carried out by protein arginine methyltransferase (PRMTs) family.	Arginine	0-8	coactivator-associated arginine methyltransferase 1	Mus musculus	75-80
28985504-4	2017	Here, we show that arginine biosynthesis and subsequent ureagenesis are collectively regulated by CLOCK (circadian locomotor output cycles kaput) in circadian rhythms.	Arginine	19-27	clock circadian regulator	Homo sapiens	98-103
28985504-4	2017	Here, we show that arginine biosynthesis and subsequent ureagenesis are collectively regulated by CLOCK (circadian locomotor output cycles kaput) in circadian rhythms.	Arginine	19-27	clock circadian regulator	Homo sapiens	105-144
28985504-5	2017	Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.	Arginine	198-206	clock circadian regulator	Homo sapiens	59-64
28808059-6	2017	The results show that these arginines relay critical information between the PCNA-binding, DNA-binding, and ATPase sites at all steps of the reaction, particularly at a checkpoint before RFC commits to ATP hydrolysis.	Arginine	28-37	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	77-81
28709807-0	2017	Identification of a new B4GalNAcT1 (GM2/GD2/GA2 synthase) isoform, and regulation of enzyme stability and intracellular transport by arginine-based motif.	Arginine	133-141	electron transfer flavoprotein subunit alpha	Homo sapiens	44-47
29045126-6	2017	Phosphorylation of Aurora-A on Thr288 is also necessary for high-affinity binding, and here we identify arginine residues that communicate the phosphorylation of Thr288 to the TPX2 binding site.	Arginine	104-112	aurora kinase A S homeolog	Xenopus laevis	19-27
28808059-7	2017	Moreover, their actions are subunit-specific with RFC-C Arg-88 serving as an accelerator that enables rapid ATP hydrolysis upon contact with ptDNA and RFC-D Arg-101 serving as a brake that confers specificity for ptDNA as the correct substrate for loading PCNA.	Arginine	56-59	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	256-260
28987270-9	2017	Our qRT-PCR exerted that there was a continuous elevation of iNOS and COX-2 genes expression over 6 and 24h after pilocarpine administration in SE and L-arginine+Zolpidem groups while in AG/L-NAME+Zolpidem and zolpidem groups this upregulation was prevented.	Arginine	151-161	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	70-75
28808059-7	2017	Moreover, their actions are subunit-specific with RFC-C Arg-88 serving as an accelerator that enables rapid ATP hydrolysis upon contact with ptDNA and RFC-D Arg-101 serving as a brake that confers specificity for ptDNA as the correct substrate for loading PCNA.	Arginine	157-160	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	256-260
28924605-11	2017	Furthermore, top-down proteomic analysis indicates that tPA cleaves FGF23 at multiple arginines including the proconvertase sensitive site R176.	Arginine	86-95	plasminogen activator, tissue	Mus musculus	56-59
29151615-1	2017	Studied were the strength characteristics of KDP crystals doped with l-arginine under a concentrated load and irradiation of the first harmonic YAG:Nd3+ laser.	Arginine	69-79	WNK lysine deficient protein kinase 1	Homo sapiens	45-48
28905880-7	2017	As RARS is involved in protein synthesis whereby it attaches arginine to its cognate tRNA, patient cells were studied to determine their ability to proliferate with limiting amounts of this essential amino acid.	Arginine	61-69	arginyl-tRNA synthetase 1	Homo sapiens	3-7
28816396-3	2017	Here, we report capillary electrophoresis-mass spectrometric (CE-MS) analysis for the separation and identification of MBP peptides that incorporate the same PTM at different sites, creating multiple localization variants, and the ability to analyze challenging modifications such as asparagine and glutamine deamidation, isomerization, and arginine citrullination.	Arginine	341-349	myelin basic protein	Mus musculus	119-122
28817220-7	2017	A key arginine residue in both HAI-1 and HAI-2 is responsible for their interaction with the S1 pocket in KLK14.	Arginine	6-14	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	31-36
28877217-7	2017	These findings demonstrate the key role of Arg-878 together with Ca2 + in APA substrate specificity for N-terminal acidic amino acid residues by ensuring the optimal positioning of acidic substrates during catalysis.	Arginine	43-46	glutamyl aminopeptidase	Mus musculus	74-77
29026071-0	2017	Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.	Arginine	0-8	B cell linker	Homo sapiens	56-73
28874751-7	2017	The glutamate is conserved between PS and PC flippases, whereas the arginine is replaced by a negatively charged aspartate in ATP8B1.	Arginine	68-76	ATPase phospholipid transporting 8B1	Homo sapiens	126-132
28949522-2	2017	Two peptides CP++ and sCP++ are designed with a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg-Gly) at both N- and C-termini.	Arginine	138-141	urocortin 3	Homo sapiens	22-25
29147481-2	2017	However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine RF-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet.	Arginine	82-90	gonadotropin releasing hormone 1	Homo sapiens	142-146
28874751-8	2017	Our mutational analysis suggests that the glutamate repels the PS head group, whereas the arginine minimizes this repulsion in ATP8A2, thereby contributing to control the entry of the phospholipid substrate into the translocation pathway.	Arginine	90-98	ATPase phospholipid transporting 8A2	Homo sapiens	127-133
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Arginine	140-148	solute carrier family 7 member 2	Homo sapiens	0-33
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Arginine	69-72	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Arginine	73-76	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Arginine	73-76	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28731187-5	2017	The amino acid sequence of SHP was identified as Leu-Lys-Glu-Glu-Asn-Arg-Arg-Arg-Arg-Asp with a molecular mass of 1371.53 Da.	Arginine	73-76	nuclear receptor subfamily 0 group B member 2	Homo sapiens	27-30
28501704-1	2017	Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine.	Arginine	140-148	solute carrier family 7 member 2	Homo sapiens	35-41
29069825-0	2017	Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300.	Arginine	38-46	E1A binding protein p300	Homo sapiens	103-107
29033912-4	2017	P. gingivalis expresses arginine gingipains, that cleave proteins at the arginine residues, and peptidyl arginine deiminase (PPAD), which citrullinates arginine residues of proteins, thus forming neoantigens that lead to ACPA production.	Arginine	24-32	proteinase 3	Homo sapiens	221-225
28877217-0	2017	Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues.	Arginine	15-23	glutamyl aminopeptidase	Mus musculus	56-72
28877217-3	2017	We report the presence in the S1 subsite of Arg-887 (Arg-878 in mouse APA), the guanidinium moiety of which established an interaction with the electronegative sulfonate group of EC33.	Arginine	44-47	glutamyl aminopeptidase	Mus musculus	70-73
28877217-3	2017	We report the presence in the S1 subsite of Arg-887 (Arg-878 in mouse APA), the guanidinium moiety of which established an interaction with the electronegative sulfonate group of EC33.	Arginine	53-56	glutamyl aminopeptidase	Mus musculus	70-73
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	Arginine	243-248	nitric oxide synthase 1, neuronal	Mus musculus	7-18
28874603-2	2017	We found that increased pHi enabled the tumorigenic behaviors caused by somatic arginine-to-histidine mutations, which are frequent in cancer and confer pH sensing not seen with wild-type proteins.	Arginine	80-88	glucose-6-phosphate isomerase	Homo sapiens	24-27
28874603-6	2017	An Arg-to-His, but not Arg-to-Lys, mutation in the transcription factor p53 (p53-R273H) decreased its transcriptional activity and attenuated the DNA damage response in fibroblasts and breast cancer cells with high pHi.	Arginine	3-6	glucose-6-phosphate isomerase	Homo sapiens	215-218
28782047-8	2017	Further studies revealed that the substitution of P1-Tyr of ZPI with an Arg is sufficient to convert the serpin to an effective inhibitor of FIXa.	Arginine	72-75	serpin family A member 10	Homo sapiens	60-63
28716421-5	2017	In vitro assays using purified recombinant enzymes of AtADC1 and AtARGAH2 were used to show that these enzymes can function in concert to convert arginine to agmatine and putrescine.	Arginine	146-154	arginine decarboxylase 1	Arabidopsis thaliana	54-60
28716421-5	2017	In vitro assays using purified recombinant enzymes of AtADC1 and AtARGAH2 were used to show that these enzymes can function in concert to convert arginine to agmatine and putrescine.	Arginine	146-154	Arginase/deacetylase superfamily protein	Arabidopsis thaliana	65-73
28190537-11	2017	Both children are homozygous for the novel mutation c.767C&gt;G in exon 5 of the GLYCTK gene, predicted to affect the enzyme by replacing the evolutionarily conserved Proline with Arginine (P256R).	Arginine	180-188	glycerate kinase	Homo sapiens	81-87
28696262-8	2017	Examination of available sequence data suggests that Arg-135 may have originated for l-THA-like beta-elimination function in earlier evolutionary variants, and examination of available structural data suggests that a Ser84-H2O-Lys114 hydrogen-bonding network in human serine racemase lowers the pKa of the Ser84re-face base.	Arginine	53-56	serine racemase	Homo sapiens	268-283
28213359-5	2017	Here, we demonstrate that 2 conserved arginine residues, R304 and R306, of EYA1 are essential for its in vitro phosphatase activity and in vivo function during Drosophila eye development.	Arginine	38-46	EYA transcriptional coactivator and phosphatase 1	Homo sapiens	75-79
28776992-2	2017	Most nNOS inhibitors mimic l-arginine and have poor bioavailability.	Arginine	27-37	nitric oxide synthase 1	Homo sapiens	5-9
28652407-0	2017	Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300.	Arginine	0-8	E1A binding protein p300	Homo sapiens	119-123
28213359-8	2017	Taken together, our results identify the conserved arginine residues of EYA1 that play an important role for its activity, thus implicating arginine methylation as a novel regulatory mechanism of EYA function.-Li, X., Eberhardt, A., Hansen, J. N., Bohmann, D., Li, H., Schor, N. F. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.	Arginine	51-59	EYA transcriptional coactivator and phosphatase 1	Homo sapiens	72-76
28213359-8	2017	Taken together, our results identify the conserved arginine residues of EYA1 that play an important role for its activity, thus implicating arginine methylation as a novel regulatory mechanism of EYA function.-Li, X., Eberhardt, A., Hansen, J. N., Bohmann, D., Li, H., Schor, N. F. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.	Arginine	140-148	EYA transcriptional coactivator and phosphatase 1	Homo sapiens	72-76
28342021-9	2017	In addition, in the MAPK signaling pathway, pSAPK/JNK and p-Erk1/2 in LPS with Arg-Arg treatment were upregulated than that in LPS treatment.	Arginine	79-82	mitogen-activated protein kinase 3	Mus musculus	60-66
20301360-18	1993	CTLN2: Liver transplantation prevents hyperammonemic crises, corrects metabolic disturbances, and eliminates preferences for protein-rich foods; arginine administration decreases blood ammonia concentration and reduced calorie/carbohydrate intake; increased protein intake lessens hypertriglyceridemia.	Arginine	145-153	solute carrier family 25 member 13	Homo sapiens	0-5
28342021-9	2017	In addition, in the MAPK signaling pathway, pSAPK/JNK and p-Erk1/2 in LPS with Arg-Arg treatment were upregulated than that in LPS treatment.	Arginine	83-86	mitogen-activated protein kinase 3	Mus musculus	60-66
28627136-4	2017	ERH interacts directly in the nucleus with the C-terminal Arg-Gly-rich region of SAFB1/2 and co-localizes with it in the insoluble nuclear fraction.	Arginine	58-61	ERH mRNA splicing and mitosis factor	Homo sapiens	0-3
28342021-12	2017	Conversely, p-Erk1/2 in rSEC with Arg-Arg treatment was attenuated than that in rSEC treatment.	Arginine	34-37	mitogen-activated protein kinase 3	Mus musculus	14-20
28627136-4	2017	ERH interacts directly in the nucleus with the C-terminal Arg-Gly-rich region of SAFB1/2 and co-localizes with it in the insoluble nuclear fraction.	Arginine	58-61	scaffold attachment factor B	Homo sapiens	81-88
28342021-12	2017	Conversely, p-Erk1/2 in rSEC with Arg-Arg treatment was attenuated than that in rSEC treatment.	Arginine	38-41	mitogen-activated protein kinase 3	Mus musculus	14-20
27992669-0	2017	Midkine is overexpressed in acute pancreatitis and promotes the pancreatic recovery in L-arginine-induced acute pancreatitis in mice.	Arginine	87-97	midkine	Mus musculus	0-7
28627371-4	2017	All the 13 synthesized analogs possessed C-terminal arginine that is a necessary element for interaction with NRP-1.	Arginine	52-60	neuropilin 1	Homo sapiens	110-115
28627371-5	2017	The obtained results of the inhibitory activity and modeling by molecular dynamics indicate that simultaneous interactions of the basic amino acid residues in position 1 and 4 (Arg) with Neuropilin-1 are crucial and their cooperation strongly affects the inhibitory activity.	Arginine	177-180	neuropilin 1	Homo sapiens	187-199
27992669-2	2017	METHODS: In this study, the expression of MK was assayed in mice with L-arginine-induced AP.	Arginine	70-80	midkine	Mus musculus	42-44
27992669-7	2017	RESULTS: The elevation of MK expression was found in mice with AP induced by L-arginine.	Arginine	77-87	midkine	Mus musculus	26-28
28403434-14	2017	Seven of 10 probands with a compound heterozygous TGM1 genotype had a mutation at either arginine 307 or 315, providing evidence that mutations at these sites are temperature sensitive and highlighting the importance of these residues in the pathogenesis of BSI.	Arginine	89-97	transglutaminase 1	Homo sapiens	50-54
28640323-0	2017	Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.	Arginine	17-20	carboxypeptidase B2	Homo sapiens	27-68
28640323-3	2017	Based on previous work by us and others, we generated TAFI variants with one or more of residues Lys 42, Lys 43, Lys 44 and Arg 12 within the activation peptide mutated to alanine.	Arginine	124-127	carboxypeptidase B2	Homo sapiens	54-58
28640323-4	2017	Mutation of one, two, or three Lys residues or the Arg residue alone decreased the catalytic efficiency of TAFI activation by thrombin-TM by 2.4-, 3.2-, 4.7-, and 15.0-fold, respectively, and increased the TAFI concentrations required for half-maximal prolongation of clot lysis times (K1/2) by 3-, 4,- 15-, and 24-fold, respectively.	Arginine	51-54	carboxypeptidase B2	Homo sapiens	107-111
28640323-9	2017	Therefore, Lys 42, Lys 43, Lys 44 and Arg 12 are critical for the interaction of TAFI with the thrombin-TM complex, which modulates its antifibrinolytic potential.	Arginine	38-41	carboxypeptidase B2	Homo sapiens	81-85
28559451-5	2017	Surface plasmon resonance and crystallography studies revealed that the arginine-to-leucine polymorphism within ULBP0602 affected the NKG2D-ULBP6 interaction by generating an energetic hotspot.	Arginine	72-80	killer cell lectin like receptor K1	Homo sapiens	134-139
28791021-0	2017	Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression.	Arginine	45-53	solute carrier family 3 member 1	Homo sapiens	120-144
28791021-5	2017	Here, we demonstrate that anti-CD3/anti-CD28-activated human primary CD4+ and CD8+ T cells upregulate ASS expression in response to low extracellular arginine concentrations, while ASL is expressed constitutively.	Arginine	150-158	CD28 molecule	Homo sapiens	40-44
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Arginine	181-189	jagged canonical Notch ligand 2	Homo sapiens	95-99
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Arginine	16-24	Janus kinase 2	Homo sapiens	81-85
28847961-0	2017	Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.	Arginine	12-20	jumonji domain containing 7	Homo sapiens	59-64
28847961-2	2017	Here, we report that two orphan Jumonji C domain (JmjC)-containing proteins, JMJD5 and JMJD7, have divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines.	Arginine	227-236	jumonji domain containing 7	Homo sapiens	87-92
28847961-6	2017	The protease activities of JMJD5 and JMJD7 represent a mechanism for removal of histone tails bearing methylated arginine residues and define a potential mechanism of transcription regulation.	Arginine	113-121	jumonji domain containing 7	Homo sapiens	37-42
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	E1A binding protein p300	Homo sapiens	28-32
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	E1A binding protein p300	Homo sapiens	23-27
28535671-3	2017	Treatment with Arg + MeSA not only enhanced the activities of superoxide dismutase, catalase, and peroxidase but also promoted the expression levels of pathogenesis-related protein 1 gene and the activities of defense-related enzymes of phenylalanine ammonia-lyase, polyphenol oxidase, beta-1,3-glucanase, and chitinase during most of the storage periods, which were associated with lower disease incidence and disease index.	Arginine	15-18	catalase isozyme 1	Solanum lycopersicum	84-92
28535671-3	2017	Treatment with Arg + MeSA not only enhanced the activities of superoxide dismutase, catalase, and peroxidase but also promoted the expression levels of pathogenesis-related protein 1 gene and the activities of defense-related enzymes of phenylalanine ammonia-lyase, polyphenol oxidase, beta-1,3-glucanase, and chitinase during most of the storage periods, which were associated with lower disease incidence and disease index.	Arginine	15-18	peroxidase	Solanum lycopersicum	98-108
28535671-3	2017	Treatment with Arg + MeSA not only enhanced the activities of superoxide dismutase, catalase, and peroxidase but also promoted the expression levels of pathogenesis-related protein 1 gene and the activities of defense-related enzymes of phenylalanine ammonia-lyase, polyphenol oxidase, beta-1,3-glucanase, and chitinase during most of the storage periods, which were associated with lower disease incidence and disease index.	Arginine	15-18	glucan endo-1,3-beta-glucosidase B	Solanum lycopersicum	286-304
28465432-10	2017	The same set of hydrogen bonds involving either the oxygen on phospho-Thr4 and the hydroxyl on Ser2, or the phosphate on Ser2 and the Thr4 hydroxyl, can be formed by rotation of an arginine side chain, leaving the intermolecular interface otherwise unperturbed.	Arginine	181-189	jagged canonical Notch ligand 2	Homo sapiens	121-125
28559658-6	2017	RESULTS: In three single nucleotide polymorphisms (Leu125Val, Ser563Asn, and Arg670Gly) of platelet endothelial cell adhesion molecule-1, we found that the Leu-Ser-Arg haplotype was associated with a significantly increased risk for coronary artery lesions in the chronic stage (odds ratio 3.05, 95% confidence interval 1.06-8.80, p = 0.039), but not for coronary artery lesions in the acute stage.	Arginine	77-80	platelet and endothelial cell adhesion molecule 1	Homo sapiens	91-136
27317126-8	2017	Both Ala and Arg improved fed-state glycemia as well as IRbeta and pAS160 content, but only Ala led to improved glucose tolerance and insulin secretion.	Arginine	13-16	insulin receptor	Mus musculus	56-62
28260165-0	2017	L-Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathway.	Arginine	0-10	serine/threonine-protein kinase mTOR	Ovis aries	97-101
28521986-1	2017	In this study glucose reinforced Fe3O4@cellulose glyconanoparticles (MGN) were prepared using epichlorohydrin and amino acid (lysine and arginine) as a linker.	Arginine	137-145	helt bHLH transcription factor	Homo sapiens	69-72
28598437-5	2017	Disrupting the "arginine anchor" on CENP-C for the nucleosomal acidic patch disrupts the CENP-A nucleosome structural transition and removes CENP-A nucleosomes from centromeres.	Arginine	16-24	centromere protein A	Homo sapiens	89-95
28598437-5	2017	Disrupting the "arginine anchor" on CENP-C for the nucleosomal acidic patch disrupts the CENP-A nucleosome structural transition and removes CENP-A nucleosomes from centromeres.	Arginine	16-24	centromere protein A	Homo sapiens	141-147
28260165-6	2017	These novel findings indicate that increasing extra-cellular arginine concentration from 50 to 200 micromol/L activates mTOR cell signaling in BAPCs and enhances their growth and development in a dose-dependent manner.	Arginine	61-69	serine/threonine-protein kinase mTOR	Ovis aries	120-124
28783661-7	2017	The citrullination-enhanced interaction of p65 with importin alpha3 and its nuclear translocation and transcriptional activity can be attributed to citrullination of four arginine residues located in the Rel homology domain of p65.	Arginine	171-179	RELA proto-oncogene, NF-kB subunit	Homo sapiens	43-46
28783661-7	2017	The citrullination-enhanced interaction of p65 with importin alpha3 and its nuclear translocation and transcriptional activity can be attributed to citrullination of four arginine residues located in the Rel homology domain of p65.	Arginine	171-179	karyopherin subunit alpha 3	Homo sapiens	52-67
28783661-7	2017	The citrullination-enhanced interaction of p65 with importin alpha3 and its nuclear translocation and transcriptional activity can be attributed to citrullination of four arginine residues located in the Rel homology domain of p65.	Arginine	171-179	RELA proto-oncogene, NF-kB subunit	Homo sapiens	227-230
28806746-4	2017	Treatment of lung cancer cells with identified inhibitors led to inhibition of the symmetrical arginine methylation of SmD3 and histones and the cellular proliferation.	Arginine	95-103	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	119-123
28207944-6	2017	RESULTS: The odds ratios of serum cystatin C level and PISA (fourth quartile) were significantly positive for both Arg (2.52; p = 0.035) and Ala allele non-carriers (2.36; p = 0.021).	Arginine	115-118	cystatin C	Homo sapiens	34-44
28586010-0	2017	Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1.	Arginine	29-39	heat shock factor 1	Mus musculus	140-159
28587687-3	2017	In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine.	Arginine	70-78	ornithine decarboxylase 1	Homo sapiens	122-145
28207944-7	2017	A significant association was also found between serum cystatin C level and BMI for both Arg (1.18; p = 0.001) and Ala allele non-carriers (1.12; p = 0.003).	Arginine	89-92	cystatin C	Homo sapiens	55-65
28587687-3	2017	In the traditional pathway for polyamine synthesis, arginase converts arginine into ornithine, which is decarboxylated by ornithine decarboxylase (ODC1) to generate putrescine.	Arginine	70-78	ornithine decarboxylase 1	Homo sapiens	147-151
28587687-6	2017	Specifically, arginine decarboxylase (ADC) catalyzes the conversion of arginine into agmatine, which is hydrolyzed by agmatinase (AGMAT) to form putrescine.	Arginine	14-22	agmatinase	Homo sapiens	118-128
28586010-9	2017	These data suggest that resveratrol protects against L-arginine-induced ANP, which may be related to the enhancement of SIRT1-mediated deacetylation of p53 and HSF1.	Arginine	53-63	heat shock factor 1	Mus musculus	160-164
28587687-6	2017	Specifically, arginine decarboxylase (ADC) catalyzes the conversion of arginine into agmatine, which is hydrolyzed by agmatinase (AGMAT) to form putrescine.	Arginine	14-22	agmatinase	Homo sapiens	130-135
28487700-7	2017	Addition of exogenous l-arginine had no effect on transforming growth factor-beta production by PBMCs or CBMCs, but enhanced IL-10 production by neonatal CD4+CD25+FoxP3+ Tregs.	Arginine	22-32	forkhead box P3	Homo sapiens	163-168
27933579-5	2017	Independent mutation of three highly conserved arginines (R122, R131, and R135) to glycine in DmHsp27 results in only one population of higher molecular weight form.	Arginine	47-56	Heat shock protein 27	Drosophila melanogaster	94-101
28195308-7	2017	Furthermore, examination of glutamate receptor 2 (GluA2) messenger RNA (mRNA) revealed that editing efficiency at the glutamine/arginine site was significantly low.	Arginine	128-136	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	50-55
28446610-4	2017	In Kir2.1, mutation of one of these CD-I salt bridge residues (R204A) reduces apparent PIP2 sensitivity of channel activity, and here we show that Ala or Cys substitutions of the functionally equivalent residue (Arg-165) in the prokaryotic Kir channel KirBac1.1 also significantly decrease sensitivity of the channel to PIP2 (by 5-30-fold).	Arginine	212-215	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	3-9
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Arginine	34-37	aldehyde dehydrogenase 2 family member	Homo sapiens	206-211
28558680-6	2017	While dietary arginine increased total lipids, total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol and triacylglycerols in NPD, the inverse effect was observed in RPD.	Arginine	14-22	LDL	Sus scrofa	83-98
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	chromatin-silencing transcriptional regulator TUP1	Saccharomyces cerevisiae S288C	154-158
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	mitogen-activated protein kinase kinase kinase STE11	Saccharomyces cerevisiae S288C	166-171
27983729-7	2017	Of 31 nonsense mutations, 23 (74%) occurred in the 11 Arginine codons of the RB1.	Arginine	54-62	RB transcriptional corepressor 1	Homo sapiens	77-80
28302728-4	2017	Using thrombin as the protease, Cdc50p remains intact and in complex with Drs2p, which is cleaved at two positions, namely after Arg104 and after Arg 1290, resulting in a homogeneous sample lacking 104 and 65 residues from its N and C termini, respectively.	Arginine	129-132	aminophospholipid-translocating P4-type ATPase DRS2	Saccharomyces cerevisiae S288C	74-79
28583108-4	2017	RESULTS: Target region capture sequencing yielded a novel missense mutation in codon 2304 (G2304R), which is a heterozygous A to G point mutation at position 6910 (c.6910A &gt; G) in exon 46 of SYNE1 leading to a glycine-to-arginine substitution (p.Gly2304Arg).	Arginine	224-232	spectrin repeat containing nuclear envelope protein 1	Homo sapiens	194-199
28166447-6	2017	Myeloid-derived suppressor cells express arginase 1, which depletes arginine, causing immunosuppression and impaired wound healing.	Arginine	68-76	arginase 1	Homo sapiens	41-51
28545736-4	2017	Much like IDO1, arginase 1 (Arg1) is an immunoregulatory enzyme that catalyzes the degradation of arginine.	Arginine	98-106	arginase 1	Homo sapiens	16-26
28545736-4	2017	Much like IDO1, arginase 1 (Arg1) is an immunoregulatory enzyme that catalyzes the degradation of arginine.	Arginine	98-106	arginase 1	Homo sapiens	28-32
28254885-2	2017	In this study, we demonstrate that PDGF-D binds directly to neuropilin 1 (NRP1), in a manner that requires the PDGF-D C-terminal Arg residue.	Arginine	129-132	neuropilin 1	Homo sapiens	60-72
28254885-2	2017	In this study, we demonstrate that PDGF-D binds directly to neuropilin 1 (NRP1), in a manner that requires the PDGF-D C-terminal Arg residue.	Arginine	129-132	neuropilin 1	Homo sapiens	74-78
28290605-5	2017	However, the co-culture of human islets with ADMSCs overexpressing betatrophin (ADMSCs-BET) induced islet proliferation, beta-cell specific transcription factor expression, and the islet production of insulin under the stimulation of glucose or KCl and Arg.	Arginine	253-256	delta/notch like EGF repeat containing	Homo sapiens	87-90
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	4-7	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	44-50
28358054-5	2017	In ASS1-knockout cells, DEPTOR, an inhibitor of mTORC1 signal, was downregulated and mTORC1 signaling was more activated in response to arginine.	Arginine	136-144	CREB regulated transcription coactivator 1	Mus musculus	85-91
28324019-7	2017	We also found that l-arginine upregulated GLUT-1/GLUT-4 expression and translocation, which were related to increased glucose uptake; however, these responses were significantly blocked by N(G)-nitro-l-arginine methylester.	Arginine	19-29	solute carrier family 2 member 1	Rattus norvegicus	42-48
28158808-0	2017	Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.	Arginine	78-86	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	36-42
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	8-11	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	44-50
28093224-9	2017	These data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of COPD.	Arginine	26-29	COPD	Homo sapiens	136-140
28612701-0	2017	Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site.	Arginine	100-108	neuraminidase 1	Homo sapiens	0-13
28087667-4	2017	PRMT5 is the main PRMT responsible for symmetric dimethylation of arginine residues of histones and other proteins.	Arginine	66-74	protein arginine N-methyltransferase 5	Mus musculus	0-5
28612701-0	2017	Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site.	Arginine	100-108	neuraminidase 1	Homo sapiens	126-139
28093224-9	2017	These data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of COPD.	Arginine	30-33	COPD	Homo sapiens	136-140
28612701-6	2017	An analysis of publicly available neuraminidase gene sequences showed that viruses with histidine at position 150 were rapidly replaced by viruses with arginine at this position between 2005 and 2008, in agreement with the phenotypic data.	Arginine	152-160	neuraminidase 1	Homo sapiens	34-47
28087667-4	2017	PRMT5 is the main PRMT responsible for symmetric dimethylation of arginine residues of histones and other proteins.	Arginine	66-74	coactivator-associated arginine methyltransferase 1	Mus musculus	0-4
28071686-11	2017	ARG1 and NOS3 in cluster 4 were enriched in biological process of arginine catabolic process.	Arginine	66-74	arginase 1	Homo sapiens	0-4
28315470-8	2017	At the individual gene level, we identified many differentially expressed genes of the citrulline/arginine metabolism pathway such as ARG1, ARG2, GLS, OAT and OTC in response to EGF and INDO.	Arginine	98-106	arginase 1	Homo sapiens	134-138
28401144-5	2017	In contrast, an earlier in vivo mutational study identified a glycine to arginine mutation at the position 168 on the B. subtilis SPL that is &gt;15 A away from the enzyme active site.	Arginine	73-81	sphingosine-1-phosphate lyase 1	Homo sapiens	130-133
28840768-1	2017	HBD: c.442T&gt;C is a new mutation at the stop codon (TGA&gt;CGA) of the delta-globin gene, which produces a new codon for arginine.	Arginine	123-131	hemoglobin subunit alpha 1	Homo sapiens	73-85
28306503-5	2017	Moreover, arginine-rich dipeptide repeats (DPRs) derived from C9orf72 hexanucleotide repeat expansions similarly undergo LLPS and induce phase separation of a large set of proteins involved in RNA and stress granule metabolism.	Arginine	10-18	C9orf72-SMCR8 complex subunit	Homo sapiens	62-69
28089735-0	2017	Effects of simvastatin on CAT-1-mediated arginine transport and NO level under high glucose conditions in conditionally immortalized rat inner blood-retinal barrier cell lines (TR-iBRB).	Arginine	41-49	solute carrier family 7 member 1	Rattus norvegicus	26-31
28089735-9	2017	CONCLUSION: Our results suggest that, in the presence of high-glucose levels, increased l-arginine uptake due to simvastatin treatment was associated with increased CAT-1 and eNOS mRNA levels, leading to higher NO production in TR-iBRB cells.	Arginine	88-98	solute carrier family 7 member 1	Rattus norvegicus	165-170
28167531-3	2017	Editing of one adenosine in the transcript encoding the glutamate receptor subunit B, glutamate receptor ionotropic AMPA 2 (GRIA2), modifies a codon, replacing the genomically encoded glutamine (Q) with arginine (R); thus this editing site is referred to as the Q/R site.	Arginine	203-211	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	86-122
28167531-3	2017	Editing of one adenosine in the transcript encoding the glutamate receptor subunit B, glutamate receptor ionotropic AMPA 2 (GRIA2), modifies a codon, replacing the genomically encoded glutamine (Q) with arginine (R); thus this editing site is referred to as the Q/R site.	Arginine	203-211	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	124-129
28440612-5	2017	However, with the WRN (Cys1367Arg) gene,the heterozygous genotype and arginine allele were associated with increased risk (prevalence ratio= 25.62; p-value=0.0001).	Arginine	70-78	WRN RecQ like helicase	Homo sapiens	18-21
28416846-2	2017	The Arg-Gly-Asp-Ser sequence (RGDS) was confirmed of affecting cell adhesion.	Arginine	4-7	ral guanine nucleotide dissociation stimulator	Homo sapiens	30-34
28406455-6	2017	The homology model of the PR1 structure shows that the cluster of positively charged amino acid residues (arginines 60, 67, 137, and lysine 135) could indeed interact with negatively charged phospholipids of cellular membranes.	Arginine	106-115	pathogenesis-related protein 1	Arabidopsis thaliana	26-29
28440612-8	2017	However, there is a high risk in patients with HIV/AIDS who have theheterozygous genotype and the arginine allele in the WRN (Cys1367Arg) gene singly.	Arginine	98-106	WRN RecQ like helicase	Homo sapiens	121-124
27789348-3	2017	Molecular dynamics (MD) simulations of galactokinase with the active site residues Arg-37 and Asp-186 altered predicted that two regions (residues 174-179 and 231-240) had different dynamics as a consequence.	Arginine	83-86	galactokinase 1	Homo sapiens	39-52
28302677-8	2017	Here, we describe that substituting Lys-119/Arg-120 and Lys-125 residues in the predicted integrin-binding interface of FGF2 to glutamic acid (the K119E/R120E and K125E mutations) effectively reduced integrin binding to FGF2.	Arginine	44-47	fibroblast growth factor 2	Mus musculus	120-124
27569446-1	2017	Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1), endothelial (NOS3), and inducible (NOS2) nitric oxide synthases.	Arginine	61-71	nitric oxide synthase 1	Homo sapiens	85-89
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Arginine	223-231	solute carrier family 3 member 1	Homo sapiens	97-103
27895153-6	2017	Attenuation of Ku80 ubiquitylation by replacement of ubiquitylation site lysines with arginine residues delayed Ku70/80 release from chromatin after DSB induction by genotoxic insults.	Arginine	86-94	X-ray repair cross complementing 5	Homo sapiens	15-19
28250926-6	2017	RESULTS: In comparison with macrophages from wildtype mice, those from congenic properdin deficient mice showed skewing towards M2 profile, encompassing mRNA expression for genes involved in arginine metabolism, production of type 2 cytokines, and relatively lower surface expression of molecules needed for antigen presentation.	Arginine	191-199	complement factor properdin	Mus musculus	80-89
28067368-0	2017	The effect of arginine on the Wnt/beta-catenin signaling pathway during porcine intramuscular preadipocyte differentiation.	Arginine	14-22	catenin beta 1	Sus scrofa	34-46
28074910-5	2017	Silencing of MYPT1 increased the level of the PRMT5-specific symmetric dimethylation on arginine residues of histone 2 A/4, a repressing gene expression mark, and it resulted in a global change in the expression of genes affecting cellular processes like growth, proliferation and cell death, also affecting the expression of the retinoblastoma protein and c-Myc.	Arginine	88-96	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	13-18
27604867-8	2017	Mutation of this site to arginine resulted in prolonged nuclear localization of ZO-2 in nuclear recruitment assays.	Arginine	25-33	tight junction protein 2	Homo sapiens	80-84
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	arginase 1	Homo sapiens	143-147
28158539-0	2017	Defects in methylation of arginine 37 on CENP-A/Cse4 are compensated by the ubiquitin ligase complex Ubr2/Mub1.	Arginine	26-34	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	48-52
28158539-3	2017	Cse4, the CENP-A homologue from Saccharomyces cerevisiae, is methylated on arginine 37 in its N-terminus (R37), and the absence of methylation (cse4-R37A) causes synthetic genetic defects in combination with mutations or deletions in genes encoding components of the Ctf19/CCAN complex and with the CDEI binding protein Cbf1.	Arginine	75-83	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	0-4
28053320-4	2017	We found that SLE group displayed significantly shorter CDR3 average length (14.86+-0.76aa vs 15.70+-0.43aa), more arginine percentage of CDR3 amino acids (7.57+-0.20% vs 7.32+-0.19%) and poorer immunological diversity than the healthy ones.	Arginine	115-123	CDR3	Homo sapiens	138-142
28367658-0	2017	A Novel alpha2-Globin Gene Mutation: Hb Debao [alpha31(B12)Arg Trp; HBA2: c.94A&gt;T].	Arginine	59-62	hemoglobin subunit alpha 2	Homo sapiens	8-21
28367658-0	2017	A Novel alpha2-Globin Gene Mutation: Hb Debao [alpha31(B12)Arg Trp; HBA2: c.94A&gt;T].	Arginine	59-62	hemoglobin subunit alpha 2	Homo sapiens	68-72
28367658-1	2017	We report a novel mutation on the alpha2-globin gene, Hb Debao [alpha31(B12)Arg Trp; HBA2: c.94A&gt;T] detected in a Chinese family.	Arginine	76-79	hemoglobin subunit alpha 2	Homo sapiens	34-47
28367658-1	2017	We report a novel mutation on the alpha2-globin gene, Hb Debao [alpha31(B12)Arg Trp; HBA2: c.94A&gt;T] detected in a Chinese family.	Arginine	76-79	hemoglobin subunit alpha 2	Homo sapiens	85-89
27863399-5	2016	We found that a WRN variant containing a phenylalanine residue at position 1074 and an arginine at position 1367 (eYFP-WRN(F-R)) possesses more affinity for DNA-PKc, KU86, KU70, and PARP1 than a variant containing a leucine at position 1074 and a cysteine at position 1367 (eYFP-WRN(L-C)).	Arginine	87-95	WRN RecQ like helicase	Homo sapiens	16-19
27863399-5	2016	We found that a WRN variant containing a phenylalanine residue at position 1074 and an arginine at position 1367 (eYFP-WRN(F-R)) possesses more affinity for DNA-PKc, KU86, KU70, and PARP1 than a variant containing a leucine at position 1074 and a cysteine at position 1367 (eYFP-WRN(L-C)).	Arginine	87-95	WRN RecQ like helicase	Homo sapiens	119-122
27863399-5	2016	We found that a WRN variant containing a phenylalanine residue at position 1074 and an arginine at position 1367 (eYFP-WRN(F-R)) possesses more affinity for DNA-PKc, KU86, KU70, and PARP1 than a variant containing a leucine at position 1074 and a cysteine at position 1367 (eYFP-WRN(L-C)).	Arginine	87-95	WRN RecQ like helicase	Homo sapiens	119-122
28069952-1	2017	The toxic proline:arginine (PRn) poly-dipeptide encoded by the (GGGGCC)n repeat expansion in the C9orf72 form of heritable amyotrophic lateral sclerosis (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules into and out of the nucleus.	Arginine	18-26	C9orf72-SMCR8 complex subunit	Homo sapiens	97-104
27760279-1	2016	The nitric oxide synthases (NOS) catalyze a two-step oxidation of l-arginine (Arg) to generate NO.	Arginine	66-76	nitric oxide synthase 1	Homo sapiens	4-26
28028182-0	2017	Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function.	Arginine	75-83	superoxide dismutase 2	Homo sapiens	116-138
27760279-1	2016	The nitric oxide synthases (NOS) catalyze a two-step oxidation of l-arginine (Arg) to generate NO.	Arginine	78-81	nitric oxide synthase 1	Homo sapiens	4-26
28382155-3	2017	Lactam bridge-cyclized alpha-melanocyte-stimulating hormone (Ac-Nle4-cyclo[Asp5-His-D-Phe7-Arg-Trp-Lys10]-NH2, or Nle-CycMSHhex) analogues have been successfully developed and studied for MC1R-targeted imaging, predominantly with single-photon emission computed tomography (SPECT).	Arginine	91-94	pro-opiomelanocortin-alpha	Mus musculus	23-59
27760279-6	2016	To test this, we utilized single catalytic turnover and stop-freeze methods, along with electron paramagnetic resonance spectroscopy, to measure the rate and extent of reduction of the 5-methyl-H4 B radical formed in neuronal NOS (nNOS) during Arg hydroxylation.	Arginine	244-247	nitric oxide synthase 1	Homo sapiens	217-229
27760279-6	2016	To test this, we utilized single catalytic turnover and stop-freeze methods, along with electron paramagnetic resonance spectroscopy, to measure the rate and extent of reduction of the 5-methyl-H4 B radical formed in neuronal NOS (nNOS) during Arg hydroxylation.	Arginine	244-247	nitric oxide synthase 1	Homo sapiens	231-235
27656708-4	2016	We show that common genetic variations at the KLKB1 and F12 loci are strongly associated with serum L-arginine levels.	Arginine	100-110	kallikrein B1	Homo sapiens	46-51
28108607-2	2017	IGFBP-1 can affect cellular functions independently of IGF binding through an Arg-Gly-Asp (RGD) integrin-binding motif.	Arginine	78-81	insulin-like growth factor binding protein 1	Mus musculus	0-7
27656708-5	2016	The G allele of single nucleotide polymorphism (SNP) rs71640036 (T/G) in KLKB1 is associated with lower serum L-arginine concentrations (10 micromol/l per allele copy, p=1x10-24), while allele T of rs2545801 (T/C) near the F12 gene is associated with lower serum L-arginine levels (7 micromol/l per allele copy, p=7x10-12).	Arginine	110-120	kallikrein B1	Homo sapiens	73-78
27656708-5	2016	The G allele of single nucleotide polymorphism (SNP) rs71640036 (T/G) in KLKB1 is associated with lower serum L-arginine concentrations (10 micromol/l per allele copy, p=1x10-24), while allele T of rs2545801 (T/C) near the F12 gene is associated with lower serum L-arginine levels (7 micromol/l per allele copy, p=7x10-12).	Arginine	263-273	kallikrein B1	Homo sapiens	73-78
28003379-4	2017	We observed that the third position of Vbeta11 CDR3 can encode an Arg or Ser residue as a result of somatic rearrangement.	Arginine	66-69	CDR3	Homo sapiens	47-51
27839528-5	2016	Furthermore, reducing arginine concentration stimulated greater expression of cationic amino acid transporter (CAT1), excitatory amino acid transporter (EAAT3) and alanine/serine/cysteine transporter (ASCT1) mRNA by IPEC-J2 cells, which was verified by elevated efficiency of amino acid uptake.	Arginine	22-30	solute carrier family 7 member 1	Sus scrofa	111-115
28150868-0	2017	Identification of second arginine-glycine-aspartic acid motif of ovine vitronectin as the complement C9 binding site and its implication in bacterial infection.	Arginine	25-33	vitronectin	Capra hircus	71-82
28067368-5	2017	We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level.	Arginine	128-136	catenin beta 1	Sus scrofa	42-54
28067368-5	2017	We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level.	Arginine	128-136	catenin beta 1	Sus scrofa	197-209
28067368-6	2017	These findings suggested that arginine promotes porcine intramuscular preadipocyte differentiation, which might be via repressing the Wnt/beta-catenin signaling pathway.	Arginine	30-38	catenin beta 1	Sus scrofa	138-150
27943578-4	2017	We found that oral administration of both L-arginine and L-ornithine significantly increased total plasma GLP-1 levels to a similar level in GPRC6A KO and WT mice 15 minutes after gavage (both amino acids) and accumulated up to 60 minutes after gavage (L-arginine).	Arginine	42-52	glucagon	Mus musculus	106-111
27943578-6	2017	In summary, these data confirm that L-arginine is a potent GLP-1 secretagogue and show that the main effect occurs independently of GPRC6A.	Arginine	36-46	glucagon	Mus musculus	59-64
27839528-5	2016	Furthermore, reducing arginine concentration stimulated greater expression of cationic amino acid transporter (CAT1), excitatory amino acid transporter (EAAT3) and alanine/serine/cysteine transporter (ASCT1) mRNA by IPEC-J2 cells, which was verified by elevated efficiency of amino acid uptake.	Arginine	22-30	solute carrier family 1 member 4	Sus scrofa	201-206
28306503-7	2017	Together with recent reports showing that DPRs affect nucleocytoplasmic transport, our results point to an important role for arginine-rich DPRs in the pathogenesis of C9orf72 ALS/FTLD.	Arginine	126-134	C9orf72-SMCR8 complex subunit	Homo sapiens	168-175
27819327-8	2016	Site-directed mutagenesis experiments have implicated a basic surface including the side chains of Arg 6, His 11 and Lys 32 as potentially important in the FS50 NaV1.5 interaction.	Arginine	99-102	sodium voltage-gated channel alpha subunit 5	Rattus norvegicus	161-167
28272331-4	2017	In general, OAT serves to form glutamate from ornithine, with the notable exception of the intestine, where citrulline (Cit) or arginine (Arg) are end products.	Arginine	138-141	ornithine aminotransferase	Homo sapiens	12-15
28119468-14	2017	We show here that the human opportunistic fungal pathogen Candida albicans influences l-arginine availability for nitric oxide production by induction of the substrate-competing host enzyme arginase-1.	Arginine	86-96	arginase 1	Homo sapiens	190-200
27865840-6	2017	Furthermore, mutation at Arg-96 abrogated the cofilin-phosphatase activity of SSH1 in the presence of F-actin.	Arginine	25-28	cofilin 1	Homo sapiens	46-53
27742792-2	2016	An inherited mutation converting arginine residue 9 in PLN to cysteine (R9C) results in dilated cardiomyopathy (DCM) in humans and transgenic mice, but the downstream signaling defects leading to decompensation and heart failure are poorly understood.	Arginine	33-41	phospholamban	Homo sapiens	55-58
27979648-2	2017	HnRNP A1 is a major non-histone target of protein arginine methyltransferase 1, which asymmetrically dimethylates hnRNP A1 at several key arginine residues within its arginine-glycine-glycine (RGG)-motif region.	Arginine	50-58	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	0-8
27979648-2	2017	HnRNP A1 is a major non-histone target of protein arginine methyltransferase 1, which asymmetrically dimethylates hnRNP A1 at several key arginine residues within its arginine-glycine-glycine (RGG)-motif region.	Arginine	50-58	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	114-122
27979648-8	2017	Our data suggest that arginine residues within the RGG-motif region are critical for hnRNP A1 cytoplasmic activities and that endogenous asymmetric dimethylation of the RGG-motif region suppresses hnRNP A1 ITAF activity in cells.	Arginine	22-30	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	85-93
27849571-10	2017	These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis.	Arginine	28-36	EYA transcriptional coactivator and phosphatase 1	Homo sapiens	102-106
27849571-10	2017	These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis.	Arginine	28-36	SIX homeobox 1	Homo sapiens	107-111
27353011-12	2017	ITC based analysis of salt dependence of binding constant gave a charge value (Z) = +4.01, as determined for the deltalnK/deltaln[Na+ ] parameter, suggesting the participation of only 3-4 Arg out of 11 Arg charge from REV peptide.	Arginine	188-191	Rev	Human immunodeficiency virus 1	218-221
27353011-12	2017	ITC based analysis of salt dependence of binding constant gave a charge value (Z) = +4.01, as determined for the deltalnK/deltaln[Na+ ] parameter, suggesting the participation of only 3-4 Arg out of 11 Arg charge from REV peptide.	Arginine	202-205	Rev	Human immunodeficiency virus 1	218-221
28214225-1	2017	Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation.	Arginine	118-128	arginase 1	Homo sapiens	0-10
28214225-1	2017	Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation.	Arginine	118-128	arginase 1	Homo sapiens	12-16
27639428-2	2016	In yeast, mutation of arginine residues away from the active site results in a ricin toxin A chain (RTA) variant that is unable to bind the ribosome and exhibits reduced cytotoxicity.	Arginine	22-30	RNA binding fox-1 homolog 2	Homo sapiens	100-103
28052029-0	2017	Arg-Leu-Tyr-Glu tetrapeptide inhibits tumor progression by suppressing angiogenesis and vascular permeability via VEGF receptor-2 antagonism.	Arginine	0-3	kinase insert domain protein receptor	Mus musculus	114-129
27903651-3	2017	Using a reduced complexity in vitro macrophage-T cell co-culture system, we show that macrophage arginase-1 is the only factor required by M2 macrophages to block T cells in G1, and this effect is mediated by l-arginine elimination rather than metabolite generation.	Arginine	209-219	arginase 1	Homo sapiens	97-107
27903651-6	2017	After 2 days of arginine deprivation, mTORC1 activity declined paralleling a selective down-regulation of SREBP target gene expression, whereas mRNAs involved in glycolysis, gluconeogenesis, and T cell activation were unaffected.	Arginine	16-24	CREB regulated transcription coactivator 1	Mus musculus	38-44
27903651-8	2017	Arginine deprivation-induced cell cycle arrest was mediated in part by Rictor/mTORC2, providing evidence that this nutrient recognition pathway is a central component of how T cells measure environmental arginine.	Arginine	0-8	CREB regulated transcription coactivator 2	Mus musculus	78-84
27903651-8	2017	Arginine deprivation-induced cell cycle arrest was mediated in part by Rictor/mTORC2, providing evidence that this nutrient recognition pathway is a central component of how T cells measure environmental arginine.	Arginine	204-212	CREB regulated transcription coactivator 2	Mus musculus	78-84
27556423-3	2016	Site-directed mutagenesis performed on highly conserved arginine residues located in the positively charged channel connecting mMDH and CS active sites led to the identification of CS(R65A) which retained high catalytic efficiency.	Arginine	56-64	citrate synthase	Homo sapiens	136-138
28052131-1	2017	The paracaspase MALT1 has arginine-directed proteolytic activity triggered by engagement of immune receptors.	Arginine	26-34	MALT1 paracaspase	Homo sapiens	16-21
27911441-8	2017	Furthermore, mutation of K143 to arginine to mimic eIF2alpha deacetylation confers protection against ER stress-induced apoptosis.	Arginine	33-41	eukaryotic translation initiation factor 2A	Mus musculus	51-60
27556423-3	2016	Site-directed mutagenesis performed on highly conserved arginine residues located in the positively charged channel connecting mMDH and CS active sites led to the identification of CS(R65A) which retained high catalytic efficiency.	Arginine	56-64	citrate synthase	Homo sapiens	181-183
27774581-5	2017	Patients with psoriasis showed a strong association for IL17F rs763780 [odds ratio (OR) = 3 27, P = 0 04], which results in a histidine-to-arginine substitution, and JAK2 rs2274471 (OR = 2 66, P = 0 02).	Arginine	139-147	interleukin 17F	Homo sapiens	56-61
27624579-10	2017	CONCLUSIONS: Basal IAPP secretion is higher in T2DM and IGT versus NGT but is reduced in response to hyperglycemia and arginine.	Arginine	119-127	islet amyloid polypeptide	Homo sapiens	19-23
27568928-1	2016	In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the immunodominant DQ8-glia-alpha1 epitope, whereupon a non-germline-encoded arginine residue played a key role in binding HLA-DQ8-glia-alpha1.	Arginine	170-178	T cell receptor alpha variable 8-3	Homo sapiens	59-66
27706899-9	2017	The GA loaded in FA-Arg-PEUU NP carriers at as low as 0.6 microg/mL GA concentration led to lower MMP-2 and MMP-9 activity of cancer cells compared to free GA, suggesting that GA-loaded Arg-PEUU NPs may have greater potential to reduce cancer cell invasion and metastasis than free GA.   2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 475-490, 2017.	Arginine	20-23	matrix metallopeptidase 2	Homo sapiens	98-103
27706899-9	2017	The GA loaded in FA-Arg-PEUU NP carriers at as low as 0.6 microg/mL GA concentration led to lower MMP-2 and MMP-9 activity of cancer cells compared to free GA, suggesting that GA-loaded Arg-PEUU NPs may have greater potential to reduce cancer cell invasion and metastasis than free GA.   2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 475-490, 2017.	Arginine	186-189	matrix metallopeptidase 2	Homo sapiens	98-103
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	33-41	T cell receptor alpha variable 8-3	Homo sapiens	185-192
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	148-156	T cell receptor alpha variable 8-3	Homo sapiens	185-192
27183218-14	2016	A significant role of CXCL4 was confirmed in an alternate model of AP induced by L-arginine challenge.	Arginine	81-91	platelet factor 4	Homo sapiens	22-27
27762493-4	2017	Here, we have addressed this limitation through the development of a controlled release system, matrix-metalloproteinase (MMP)-sensitive and arg-gly-asp-ser (RGDS) peptide functionalized poly (ethylene-glycol) (PEG) particles which are synthesized via visible-light-induced water-in-water emulsion polymerization.	Arginine	141-144	ral guanine nucleotide dissociation stimulator	Homo sapiens	158-162
28000813-3	2017	In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells.	Arginine	141-144	furin, paired basic amino acid cleaving enzyme	Homo sapiens	218-223
28000813-3	2017	In this work, by integrating a biocompatible condensation reaction with an AIE fluorogen, we rationally designed a "smart" dual AIE probe Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(TPE)-CBT (1) for enhanced fluorescence sensing furin activity in vitro and in living cells.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	218-223
28055018-4	2017	Intriguingly, the mutant Prdx6 K122/142 R (arginine) gained protective efficacy, increasing in abundance and promoting glutathione (GSH) peroxidase and acidic calcium-independent phospholipase A2 (aiPLA2) activities.	Arginine	43-51	peroxiredoxin 6	Homo sapiens	25-30
28055018-4	2017	Intriguingly, the mutant Prdx6 K122/142 R (arginine) gained protective efficacy, increasing in abundance and promoting glutathione (GSH) peroxidase and acidic calcium-independent phospholipase A2 (aiPLA2) activities.	Arginine	43-51	peroxiredoxin 6	Homo sapiens	152-195
28055018-4	2017	Intriguingly, the mutant Prdx6 K122/142 R (arginine) gained protective efficacy, increasing in abundance and promoting glutathione (GSH) peroxidase and acidic calcium-independent phospholipase A2 (aiPLA2) activities.	Arginine	43-51	peroxiredoxin 6	Homo sapiens	197-203
28043134-2	2017	This investigation aimed to develop tunable bioresponsive newly synthesized unique arginine grafted poly(cystaminebis(acrylamide)-diaminohexane) [ABP] polymeric matrix based nanocarriers by using L9 Taguchi factorial design, desirability function, and multivariate method.	Arginine	83-91	amine oxidase copper containing 1	Homo sapiens	146-149
28950949-9	2017	As inflammation persists, a GPI-linked carboxypeptidase M removes the C-terminal arginine from the primary kinin, converting the B2R agonist into a high-affinity ligand for B1R, a GPCR subtype that is transcriptionally upregulated in injured/inflamed tissues.	Arginine	81-89	bradykinin receptor, beta 2	Mus musculus	129-132
27998825-2	2017	Arg1 uses the substrate l-arginine to create l-ornithine, a precursor molecule required for collagen formation and vascular smooth muscle cell differentiation.	Arginine	24-34	arginase, liver	Mus musculus	0-4
27998825-3	2017	By reducing l-arginine availability, Arg1 limits the production of nitric oxide (NO), a pro-atherogenic factor in macrophages.	Arginine	12-22	arginase, liver	Mus musculus	37-41
26766582-5	2017	In contrast, peptides having arginine residue at sites other than the C-terminus exhibited low activity towards NRP-1 and this is confirmed by their inability to displace the VEGF165 binding to NRP-1.	Arginine	29-37	neuropilin 1	Homo sapiens	112-117
26766582-8	2017	Pentapeptides having C-terminal arginine showed strong interaction and good inhibitory activity with NRP thus may be a good template for anti-angiogenic targeting agent.	Arginine	32-40	neuropilin 1	Homo sapiens	101-104
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Arginine	22-25	bone morphogenetic protein 2	Homo sapiens	75-80
28197209-8	2017	And also, we selected Arg-Gly-Asp- (RGD-) conjugated alginate hydrogel for BMP-2 delivery because alginate is able to release BMP-2 in a sustained manner and it is a biocompatible material.	Arginine	22-25	bone morphogenetic protein 2	Homo sapiens	126-131
27893431-3	2016	A Tdp1Hisgab to Arg mutant identified in patients with the autosomal recessive neurodegenerative disease SCAN1 causes stabilization of the TDP1-DNA intermediate.	Arginine	16-19	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	2-6
27893431-3	2016	A Tdp1Hisgab to Arg mutant identified in patients with the autosomal recessive neurodegenerative disease SCAN1 causes stabilization of the TDP1-DNA intermediate.	Arginine	16-19	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	139-143
28066558-0	2016	Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.	Arginine	29-37	CREB regulated transcription coactivator 1	Mus musculus	79-85
28066558-1	2016	The mTOR complex I (mTORC1) signaling pathway controls many metabolic processes and is regulated by amino acid signals, especially arginine.	Arginine	131-139	CREB regulated transcription coactivator 1	Mus musculus	20-26
28066558-2	2016	CASTOR1 has been identified as the cytosolic arginine sensor for the mTORC1 pathway, but the molecular mechanism of how it senses arginine is elusive.	Arginine	45-53	CREB regulated transcription coactivator 1	Mus musculus	69-75
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	76-84	fuzzy planar cell polarity protein	Homo sapiens	151-154
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	212-220	fuzzy planar cell polarity protein	Homo sapiens	151-154
28066558-5	2016	By comparison with structurally similar aspartate kinases, a surface patch of CASTOR1-NTD on the opposite side of the arginine-binding site was identified to mediate direct physical interaction with its downstream effector GATOR2, via GATOR2 subunit Mios.	Arginine	118-126	fuzzy planar cell polarity protein	Homo sapiens	86-89
28056232-6	2016	A mutation c. A1319G was identified in the MYLK2 gene in 1 family member, which resulted in a lysine (K) to arginine (R) exchange at amino acid residue 440.	Arginine	108-116	myosin light chain kinase 2	Homo sapiens	43-48
27992998-8	2016	We show that although all the tested fatty acids form similar contacts to the active site residues, the affinity of DHA for CYP2J2 is tighter because of the interaction of DHA with residues Arg-321, Thr-318, and Ser-493.	Arginine	190-193	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	124-130
27472651-4	2016	Here, we examined the importance of a conserved Lys/Arg residue in the ligand-binding site of the second PDZ domain of PSD-95, by employing a semisynthetic approach.	Arginine	52-55	discs large MAGUK scaffold protein 4	Homo sapiens	119-125
27616479-7	2016	Furthermore, mutations in the same positions were reported in malignant tumors, and a de novo missense substitution in an equivalent arginine residue in the C-terminal helicase domain of SMARCA4 is associated with Coffin Siris syndrome.	Arginine	133-141	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	187-194
27690003-1	2016	Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing.	Arginine	11-19	serine and arginine rich splicing factor 2	Homo sapiens	43-48
27537339-3	2016	Field studies identified scrapie-protective caprine PrP variants, harboring specific single amino acid changes (Met-142, Arg-143, Asp-146, Ser-146, His-154, Gln-211 and Lys-222).	Arginine	121-124	prion protein	Mus musculus	52-55
27737343-6	2016	L- arginine treatment stimulated TGF-beta and restricted NO production leading to a mild Th1 response and collagen deposition in injured area, when it was orally administrated.	Arginine	0-11	transforming growth factor, beta 1	Mus musculus	33-41
27464742-1	2016	This study is focused on a new amide derivative of the peptide HLDF-6 (Thr-Gly-Glu-Asn-His-Arg).	Arginine	91-94	ribosomal protein S21	Homo sapiens	63-67
27544385-7	2017	The nonsense mutation is predicted to result in a truncated TTN protein and the missense mutation leads to a substitution of glycine by arginine.	Arginine	136-144	titin	Homo sapiens	60-63
27469131-7	2017	RESULTS: WES demonstrated a homozygous novel missense ASNS mutation, c.1019G &gt; A, resulting in substitution of the highly conserved arginine residue by histidine (R340H).	Arginine	135-143	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	54-58
28123551-2	2017	This is because the cells produce glucose and arginine by the action of galactokinase (GALK) and ornithine carbamoyltransferase (OTC), respectively.	Arginine	46-54	galactokinase 1	Homo sapiens	72-85
28123551-2	2017	This is because the cells produce glucose and arginine by the action of galactokinase (GALK) and ornithine carbamoyltransferase (OTC), respectively.	Arginine	46-54	galactokinase 1	Homo sapiens	87-91
28078001-8	2016	Following the L-ARG treatment, the expression of the pro-angiogenic factors (VEGF and FGF-2) was higher and the expression of anti-angiogenic factors (endostatin) was lower than the vehicle-treated animals.	Arginine	14-19	fibroblast growth factor 2	Rattus norvegicus	86-91
27109703-12	2016	A helix from PolB containing a patch of arginine residues was involved in the binding, locking the complex in the exo mode conformation.	Arginine	40-48	DNA polymerase beta	Homo sapiens	13-17
27690010-3	2016	As one of the key environmental stimuli, amino acids (AAs), especially leucine, glutamine and arginine, play a crucial role in mTORC1 activation, but where and how AAs are sensed and signal to mTORC1 are not fully understood.	Arginine	94-102	CREB regulated transcription coactivator 1	Mus musculus	127-133
27364888-3	2016	In the last ten years, major progress has been made in the understanding of the neuronal mechanisms governing mammalian reproduction with the finding that two hypothalamic Arg-Phe-amide peptides, kisspeptin (Kp) and RFRP, regulate GnRH neurons.	Arginine	172-175	neuropeptide VF precursor	Homo sapiens	216-220
27358479-0	2016	The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.	Arginine	42-45	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-19
27625115-3	2016	We recently showed that both monomers and dimers are potent CXCR2 agonists, the dimer is the high-affinity GAG ligand, lysine and arginine residues located in two non-overlapping domains mediate GAG interactions, and there is extensive overlap between GAG and receptor-binding domains.	Arginine	130-138	C-X-C motif chemokine receptor 2	Homo sapiens	60-65
27470910-7	2016	In the ARG, the osteoblasts viability, TGF-beta1, BMP-2, IGF-I and Cbfalpha1 mRNA expressions and the GSH-Px and SOD activities were significantly increased, the ROS concentration was significantly decreased, and osteoblasts histology lesion was attenuated compared with the AG.	Arginine	7-10	bone morphogenetic protein 2	Rattus norvegicus	50-55
27765932-0	2016	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.	Arginine	41-49	deleted in esophageal cancer 1	Homo sapiens	124-128
27797450-5	2016	SUMMARY: Background Using tissue factor pathway inhibitor (TFPI)-2 Kunitz domain1 (KD1), we obtained a bifunctional antifibrinolytic molecule (KD1L17R -KT ) with C-terminal lysine (kringle domain binding) and P2"-residue arginine (improved specificity towards plasmin).	Arginine	221-229	plasminogen	Homo sapiens	260-267
27604544-1	2016	Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from partially degraded fibrin.	Arginine	133-142	carboxypeptidase B2	Homo sapiens	7-50
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Arginine	123-131	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
27686733-1	2016	Hb Zurich-Albisrieden [HBA2: c.178G &gt; C; alpha59(E8)Gly Arg (alpha2)] is a rare nondeletional alpha-thalassemia (alpha-thal) that results from a nucleotide substitution at codon 59 of the alpha2-globin gene.	Arginine	59-62	hemoglobin subunit alpha 2	Homo sapiens	23-27
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Arginine	123-131	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
27755371-6	2016	Our findings suggest that the arginine variant of the EN2 protein may play an important role in the pathology of ASD.	Arginine	30-38	engrailed homeobox 2	Homo sapiens	54-57
27717730-7	2016	Our results showed that the augmented interaction of p47PHOX with gp91PHOX subunits of the enzyme in skeletal muscle tissue in the offspring of diabetic rats (DV) was abolished after l-Arg treatment in DA rats.	Arginine	183-188	neutrophil cytosolic factor 1	Rattus norvegicus	53-60
27717730-10	2016	In addition it is possible that l-Arg exerts its effects directly onto essential molecules for the maintenance and survival of pancreatic islets, decreasing protein expression of p47PHOX while increasing Akt phosphorylation and PDX-1 expression.	Arginine	32-37	neutrophil cytosolic factor 1	Rattus norvegicus	179-186
27063995-8	2016	RESULTS: Among four SNPs analyzed, only FCGR2A 131His/Arg showed significant association with CP in a dominant model (odds ratio: 1.6; 95% confidence interval: 1.028 to 2.530).	Arginine	54-57	Fc gamma receptor IIa	Homo sapiens	40-46
27430721-5	2016	Mutation of K446 to arginine to prevent ubiquitination greatly enhanced recruitment of steroid receptor coactivator 1 (SRC1), a coactivator critical for RORgammat activity.	Arginine	20-28	nuclear receptor coactivator 1	Homo sapiens	87-117
27063995-10	2016	A significant redundant interaction between IL1B +3954 C/T and FCGR2A 131His/Arg was observed.	Arginine	77-80	Fc gamma receptor IIa	Homo sapiens	63-69
27063995-11	2016	CONCLUSION: Study results suggest the variant form of the SNP in FCGR2A 131His/Arg, FCGR2B 232Ile/Thr, TNFA -1031T/C, and TNFA -863C/A are not associated with CP susceptibility in the selected cohort from South India.	Arginine	79-82	Fc gamma receptor IIa	Homo sapiens	65-71
27833157-1	2016	The p.Thr1406Asn (rs1047891) polymorphism of the carbamoyl-phosphate synthetase 1 (CPS1) gene has been linked to functional consequences affecting the downstream availability of the nitric oxide precursor L-arginine.	Arginine	205-215	carbamoyl-phosphate synthase 1	Homo sapiens	49-81
27833157-1	2016	The p.Thr1406Asn (rs1047891) polymorphism of the carbamoyl-phosphate synthetase 1 (CPS1) gene has been linked to functional consequences affecting the downstream availability of the nitric oxide precursor L-arginine.	Arginine	205-215	carbamoyl-phosphate synthase 1	Homo sapiens	83-87
27430721-5	2016	Mutation of K446 to arginine to prevent ubiquitination greatly enhanced recruitment of steroid receptor coactivator 1 (SRC1), a coactivator critical for RORgammat activity.	Arginine	20-28	nuclear receptor coactivator 1	Homo sapiens	119-123
27739308-4	2016	Our studies have identified E264 as a critical constituent of the dual binding pocket, which regulates the catalytic activity of DUSP5 by forming a salt bridge with arginine R269.	Arginine	165-173	dual specificity phosphatase 5	Homo sapiens	129-134
27239731-1	2016	l-Arginine is the common substrate for nitric oxide synthases (NOS) and arginase.	Arginine	0-10	nitric oxide synthase 1, neuronal	Mus musculus	39-61
27409667-5	2016	Substitution of K517 with arginine abolished the SUMOylation of PES1.	Arginine	26-34	pescadillo ribosomal biogenesis factor 1	Homo sapiens	64-68
27446352-6	2016	Reduced editing at the glutamine/arginine site of the AMPA receptor subunit GluA2 in glioma, without any alteration in ADAR2 expression, is a notable phenomenon.	Arginine	33-41	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	76-81
27446352-10	2016	Dominant expression of ADAR2 splicing variant with low enzyme activity causes reduced RNA editing of GluA2 subunit at the glutamine/arginine site in glioma.	Arginine	132-140	adenosine deaminase RNA specific B1	Homo sapiens	23-28
27446352-10	2016	Dominant expression of ADAR2 splicing variant with low enzyme activity causes reduced RNA editing of GluA2 subunit at the glutamine/arginine site in glioma.	Arginine	132-140	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	101-106
27560450-5	2016	Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta.	Arginine	36-39	huntingtin	Homo sapiens	110-120
27745970-5	2016	Proteome-wide probing of structural alterations, validated by the analysis of knockout T cell clones, identified three transcriptional regulators (BAZ1B, PSIP1, and TSN) that sensed L-arginine levels and promoted T cell survival.	Arginine	182-192	PC4 and SFRS1 interacting protein 1	Homo sapiens	154-159
27097548-2	2016	Citrullination or deimination, a post-translational modification of protein-bound arginine into citrulline, catalyzed by Ca(2+) dependent peptidylarginine deiminase enzyme (PAD), plays an essential role in physiological processes include gene expression regulation, apoptosis and the plasticity of the central nervous system, while aberrant citrullination can generate new epitopes, thus involving in the initiation and/or progression of autoimmune disorder like MS. Myelin basic protein (MBP) is the major myelin protein and is generally considered to maintain the stability of the myelin sheath.	Arginine	82-90	myelin basic protein	Homo sapiens	467-487
27745970-5	2016	Proteome-wide probing of structural alterations, validated by the analysis of knockout T cell clones, identified three transcriptional regulators (BAZ1B, PSIP1, and TSN) that sensed L-arginine levels and promoted T cell survival.	Arginine	182-192	translin	Homo sapiens	165-168
27287681-0	2016	Exogenous l-arginine reduces matrix metalloproteinase-2 and -9 activities and oxidative stress in patients with hypertension.	Arginine	10-20	matrix metallopeptidase 2	Homo sapiens	29-62
27097548-2	2016	Citrullination or deimination, a post-translational modification of protein-bound arginine into citrulline, catalyzed by Ca(2+) dependent peptidylarginine deiminase enzyme (PAD), plays an essential role in physiological processes include gene expression regulation, apoptosis and the plasticity of the central nervous system, while aberrant citrullination can generate new epitopes, thus involving in the initiation and/or progression of autoimmune disorder like MS. Myelin basic protein (MBP) is the major myelin protein and is generally considered to maintain the stability of the myelin sheath.	Arginine	82-90	myelin basic protein	Homo sapiens	489-492
27447620-0	2016	The Conserved Arginine Cluster in the Insert of the Third Cytoplasmic Loop of the Long Form of the D2 Dopamine Receptor (D2L-R) Acts as an Intracellular Retention Signal.	Arginine	14-22	dopamine receptor D2	Homo sapiens	99-119
27447620-1	2016	This study examined whether the conserved arginine cluster present within the 29-amino acid insert of the long form of the D2 dopamine receptor (D2L-R) confers its predominant intracellular localization.	Arginine	42-50	dopamine receptor D2	Homo sapiens	123-143
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	39-43
27256984-8	2016	Furthermore, we found hotspot mutations in the arginine-rich stretch in MAP1LC3A resulting in reduced cleavage of MAP1LC3A by ATG4B both in vitro and in vivo, suggesting a functional implication of this gene mutation in cancer development.	Arginine	47-55	autophagy related 4B cysteine peptidase	Homo sapiens	126-131
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	199-203
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	257-260
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	199-203
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	321-324
27340743-4	2016	We demonstrate that the macromolecular MUC1 glycopeptide displaying the essential glycopeptidic neoepitope Pro-Asp-Thr(sialyl-T)-Arg-Pro-Ala-Pro at two different tandem repeats is an excellent serum MUC1 model showing ideal stoichiometric binding with anti-KL6/MUC1 antibody in the sandwich ELISA to quantify human serum KL6/MUC1 levels as a critical biomarker of interstitial lung diseases.	Arginine	129-132	mucin 1, cell surface associated	Homo sapiens	199-203
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Arginine	39-47	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	73-77
27328714-6	2016	High level of expressed sfGFP-AhR fusion protein (50 kDa) was recovered from the inclusion bodies of E. coli by simple solubilization with the Arginine, and purified by affinity chromatography via its N-terminal 6 x His tag.	Arginine	143-151	aryl hydrocarbon receptor	Homo sapiens	30-33
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Arginine	39-47	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	155-159
27332127-6	2016	The substitution of hydrophobic Ala with His or Arg in the central region of the EDEM1 or SPAST peptides, respectively, attenuated their ability to flip phospholipids.	Arginine	48-51	spastin	Homo sapiens	90-95
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Arginine	55-63	carbonic anhydrase 4	Rattus norvegicus	137-141
27302742-5	2016	Using an immunoprecipitation assay, we revealed that ubiquitin molecule was directly conjugated to Chac1, and that mutated Chac1 with all lysine residues replaced by arginine was also ubiquitinated.	Arginine	166-174	ChaC, cation transport regulator 1	Mus musculus	123-128
27309807-8	2016	Our findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation.	Arginine	54-62	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	154-158
27309807-8	2016	Our findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation.	Arginine	54-62	S-phase kinase associated protein 2	Homo sapiens	159-163
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	caspase 8	Homo sapiens	135-144
27297692-5	2016	Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation.	Arginine	85-93	CREB regulated transcription coactivator 1	Mus musculus	62-68
27285928-0	2016	Intravenous maternal -arginine administration to twin-bearing ewes, during late pregnancy, is associated with increased fetal muscle mTOR abundance and postnatal growth in twin female lambs.	Arginine	22-30	serine/threonine-protein kinase mTOR	Ovis aries	133-137
27246354-2	2016	In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs).	Arginine	27-32	arginase 1	Homo sapiens	83-93
27246354-2	2016	In breast cancer patients, L-Arg is depleted by nitric oxide synthase 2 (NOS2) and arginase 1 (ARG-1) produced by myeloid-derived suppressor cells (MDSCs).	Arginine	27-32	arginase 1	Homo sapiens	95-100
27285928-1	2016	The aims of this study were to determine whether parenteral Arg administered to well-fed twin-bearing ewes from 100 to 140 d of pregnancy influences fetal skeletal muscle growth, the abundance and activation of mechanistic target of rapamycin (mTOR) protein, and postnatal muscle growth of the offspring.	Arginine	60-63	serine/threonine-protein kinase mTOR	Ovis aries	211-242
27003113-3	2016	Furthermore, B7-H3 protein was marked increased in l-arginine-induced acute experimental pancreatitis.	Arginine	51-61	CD276 molecule	Homo sapiens	13-18
27285928-1	2016	The aims of this study were to determine whether parenteral Arg administered to well-fed twin-bearing ewes from 100 to 140 d of pregnancy influences fetal skeletal muscle growth, the abundance and activation of mechanistic target of rapamycin (mTOR) protein, and postnatal muscle growth of the offspring.	Arginine	60-63	serine/threonine-protein kinase mTOR	Ovis aries	244-248
27003113-4	2016	Anti-B7-H3 monoclonal antibody treatment attenuated the proinflammatory cytokine production, downregulated the activation of the NF-kappaB signaling pathway, and ameliorated the pancreas disruption in l-arginine-induced pancreatitis.	Arginine	201-211	CD276 molecule	Homo sapiens	5-10
27285928-8	2016	Female lambs from ewes supplemented with Arg (Arg-F) had increased abundance of total mTOR, RNA concentration, and RNA:DNA ratio in LD compared with female lambs from Control ewes (Con-F), whereas males did not differ.	Arginine	41-44	serine/threonine-protein kinase mTOR	Ovis aries	86-90
27285928-8	2016	Female lambs from ewes supplemented with Arg (Arg-F) had increased abundance of total mTOR, RNA concentration, and RNA:DNA ratio in LD compared with female lambs from Control ewes (Con-F), whereas males did not differ.	Arginine	46-49	serine/threonine-protein kinase mTOR	Ovis aries	86-90
27285928-13	2016	In conclusion, Arg administration to the ewe during gestation increases female lamb weight and muscle weight after birth and these changes are associated with altered mTOR protein abundance and have potential implications for sheep production.	Arginine	15-18	serine/threonine-protein kinase mTOR	Ovis aries	167-171
27126696-6	2016	We generated and employed a CHO-DG44 cell clone producing an rFVIII variant retaining a portion of the B-domain and the FVIII native cleavage site between Arg(1648) and Glu(1649).	Arginine	155-158	coagulation factor VIII	Homo sapiens	62-67
27199893-4	2016	Although specific mechanisms might vary among seasonal species, the hypothalamic RF (Arg-Phe) amide-related peptides (RFRP-1 and -3) are believed to play a critical role in the central control of seasonal reproduction and in all seasonal species investigated, the RFRP system is persistently inhibited in short photoperiod.	Arginine	85-88	neuropeptide VF precursor	Homo sapiens	118-122
27126696-9	2016	This work also provides the first direct evidence of (1) intracellular cleavage at the Arg(1648) FVIII processing site promoted by wild-type PACE and PCSK7 and (2) proteolytic processing at the Arg(1648) FVIII processing site by PCSK6.	Arginine	87-90	coagulation factor VIII	Homo sapiens	97-102
27126696-9	2016	This work also provides the first direct evidence of (1) intracellular cleavage at the Arg(1648) FVIII processing site promoted by wild-type PACE and PCSK7 and (2) proteolytic processing at the Arg(1648) FVIII processing site by PCSK6.	Arginine	87-90	coagulation factor VIII	Homo sapiens	204-209
27126696-9	2016	This work also provides the first direct evidence of (1) intracellular cleavage at the Arg(1648) FVIII processing site promoted by wild-type PACE and PCSK7 and (2) proteolytic processing at the Arg(1648) FVIII processing site by PCSK6.	Arginine	194-197	coagulation factor VIII	Homo sapiens	97-102
27199893-4	2016	Although specific mechanisms might vary among seasonal species, the hypothalamic RF (Arg-Phe) amide-related peptides (RFRP-1 and -3) are believed to play a critical role in the central control of seasonal reproduction and in all seasonal species investigated, the RFRP system is persistently inhibited in short photoperiod.	Arginine	85-88	neuropeptide VF precursor	Homo sapiens	264-268
26947510-2	2016	Recently, Berendse et al reported an improvement of peroxisomal functions with l-arginine supplementation in fibroblasts with specific mutations of PEX1, PEX6, and PEX12.	Arginine	79-89	peroxisomal biogenesis factor 1	Homo sapiens	148-152
26893369-3	2016	We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish Myh11.	Arginine	118-126	myosin, heavy chain 11a, smooth muscle	Danio rerio	54-62
26912033-7	2016	Nitric oxide generation induced by l-arginine and GSH/GSSG in aorta of SMP30 KO and old mice were lower than those in young mice.	Arginine	35-45	regucalcin	Mus musculus	71-76
26893369-3	2016	We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish Myh11.	Arginine	118-126	myosin, heavy chain 11a, smooth muscle	Danio rerio	64-67
26893369-3	2016	We previously reported a recessive missense mutation, meltdown (mlt), which converts a highly conserved tryptophan to arginine (W512R) in the rigid relay loop of zebrafish Myh11.	Arginine	118-126	myosin, heavy chain 11a, smooth muscle	Danio rerio	172-177
26957205-4	2016	PAR2, which like PAR1 is also cleaved at an N-terminal arginine to unmask its tethered ligand, is generally regarded as a target for trypsin but not for thrombin signaling.	Arginine	55-63	F2R like trypsin receptor 1	Homo sapiens	0-4
26874542-1	2016	BACKGROUND AND PURPOSE: High arginase-1 (Arg) expression by myeloid-derived suppressor cells (MDSC) is known to inhibit antitumor T-cell responses through depletion of l-arginine.	Arginine	168-178	arginase 1	Homo sapiens	29-39
27017485-0	2016	Regulation of autophagy by systemic admission of microRNA-141 to target HMGB1 in l-arginine-induced acute pancreatitis in vivo.	Arginine	81-91	high mobility group box 1	Mus musculus	72-77
26692170-6	2016	Two mutations in CYB5D2, the substitutions of arginine (R) 7 with either proline (P) or glycine (G), were reported in colon cancer.	Arginine	46-54	cytochrome b5 domain containing 2	Homo sapiens	17-23
27017485-10	2016	Furthermore, systemic administration of the miR-141 knock-down the expression of HMGB1 protein and further antagonized the downstream protein Beclin-1, leading to the reduction of autophagosomes and autolysosomes, blockade of the LC3-II level and the increased levels of p62 protein after injection of l-arginine.	Arginine	302-312	high mobility group box 1	Mus musculus	81-86
26975471-6	2016	Moreover, the results reported here suggest that Arg-24 of Atg16L1 is crucial for its interaction with Atg5 which will have further implication in the binding of the dimeric complex to Rab33B.	Arginine	49-52	autophagy related 5	Mus musculus	103-107
26536822-3	2016	In AML cells, PRMT5 interacted with Sp1 in a transcription repressor complex and silenced miR-29b preferentially via dimethylation of histone 4 arginine residue H4R3.	Arginine	144-152	microRNA 29b-1	Homo sapiens	90-97
26975471-6	2016	Moreover, the results reported here suggest that Arg-24 of Atg16L1 is crucial for its interaction with Atg5 which will have further implication in the binding of the dimeric complex to Rab33B.	Arginine	49-52	RAB33B, member RAS oncogene family	Mus musculus	185-191
27761413-1	2016	Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver.	Arginine	27-35	arginase, liver	Mus musculus	0-10
27051065-0	2016	Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFalpha/NF-kappaB response.	Arginine	11-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	37-41
27761413-1	2016	Arginase-1 (Arg1) converts arginine to urea and ornithine in the distal step of the urea cycle in liver.	Arginine	27-35	arginase, liver	Mus musculus	12-16
27051065-8	2016	Our findings provide evidence for the asymmetric arginine dimethylation of RelA and unveil a unique mechanism controlling TNFalpha/NF-kappaB signaling.	Arginine	49-57	RELA proto-oncogene, NF-kB subunit	Homo sapiens	75-79
26912664-3	2016	Here, we examined the biochemical basis for the poor ability of GluA3 subunits to form homomeric receptors, linked previously to two amino acid residues, Tyr-454 and Arg-461, in its ligand binding domain (LBD).	Arginine	166-169	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	64-69
27561318-1	2016	Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.	Arginine	228-231	APC regulator of WNT signaling pathway	Homo sapiens	75-78
26912664-5	2016	The secretion efficiency of GluA2 and GluA3 LBDs paralleled the transport difference between the respective full-length receptors and was similarly dependent on Tyr-454/Arg-461 but not on LBD stability.	Arginine	169-172	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	28-33
27510653-3	2016	The results demonstrated that high doses of arginine increased IL-4, IL-10 and TNF-alpha secretion of T cells, while increasing concentrations of lysine increased IL-10 secretion and proliferative activity of the T cells.	Arginine	44-52	interleukin 4	Felis catus	63-67
26912664-5	2016	The secretion efficiency of GluA2 and GluA3 LBDs paralleled the transport difference between the respective full-length receptors and was similarly dependent on Tyr-454/Arg-461 but not on LBD stability.	Arginine	169-172	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	38-43
26912664-7	2016	We conclude that the impaired surface expression of homomeric GluA3 receptors is caused by nonproductive assembly and aggregation to which LBD residues Tyr-454 and Arg-461 strongly contribute.	Arginine	164-167	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	62-67
26771234-8	2016	On the other hand, overexpression of Atg5 or AMPK-alpha1 in BR cells can redirect arginine deprivation-induced apoptosis toward autophagy.	Arginine	82-90	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	45-56
27648300-0	2016	Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.	Arginine	28-36	CREB regulated transcription coactivator 1	Mus musculus	92-98
27648300-2	2016	CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway.	Arginine	26-34	CREB regulated transcription coactivator 1	Mus musculus	98-104
27648300-3	2016	In the deficiency of arginine, CASTOR1 interacts with GATOR2, which together with GATOR1 and Rag GTPases controls the relocalization of mTORC1 to lysosomes.	Arginine	21-29	CREB regulated transcription coactivator 1	Mus musculus	136-142
27648300-4	2016	The binding of arginine to CASTOR1 disrupts its association with GATOR2 and hence activates the mTORC1 signaling.	Arginine	15-23	CREB regulated transcription coactivator 1	Mus musculus	96-102
27648300-10	2016	Our structural and functional data together reveal the molecular basis for the arginine-binding specificity of CASTOR1 in the arginine-dependent activation of the mTORC1 signaling.	Arginine	79-87	CREB regulated transcription coactivator 1	Mus musculus	163-169
26858254-4	2016	In the yeastSaccharomyces cerevisiae, the separase-mediated cleavage of the Scc1/Rad21/Mcd1 cohesin subunit generates a C-terminal fragment that bears N-terminal Arg and is destroyed by the N-end rule pathway without a requirement for arginylation.	Arginine	162-165	extra spindle pole bodies 1, separase	Mus musculus	42-50
27648300-10	2016	Our structural and functional data together reveal the molecular basis for the arginine-binding specificity of CASTOR1 in the arginine-dependent activation of the mTORC1 signaling.	Arginine	126-134	CREB regulated transcription coactivator 1	Mus musculus	163-169
27507053-0	2016	The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.	Arginine	131-139	protein arginine N-methyltransferase 5	Mus musculus	112-117
26923072-7	2016	Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in l-Arginine oxidation.	Arginine	98-108	nitric oxide synthase 1	Homo sapiens	75-79
27622275-0	2016	The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1.	Arginine	4-12	Sp110 nuclear body protein	Mus musculus	121-156
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Arginine	51-59	Sp110 nuclear body protein	Mus musculus	140-144
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Arginine	51-59	Sp110 nuclear body protein	Mus musculus	290-294
27622275-8	2016	Furthermore, our results show that this arginine/lysine-rich element contributes to the transcriptional regulation and apoptotic activity of Ipr1.	Arginine	40-48	Sp110 nuclear body protein	Mus musculus	141-145
27186329-3	2016	The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013).	Arginine	35-38	RAD17 checkpoint clamp loader component	Homo sapiens	28-34
27487210-0	2016	Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.	Arginine	13-21	CREB regulated transcription coactivator 1	Mus musculus	53-59
27487210-2	2016	In mammals arginine is particularly important, promoting diverse physiological effects such as immune cell activation, insulin secretion, and muscle growth, largely mediated through activation of mTORC1 (refs 4, 5, 6, 7).	Arginine	11-19	CREB regulated transcription coactivator 1	Mus musculus	196-202
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	19-25
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	180-186
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	160-168	CREB regulated transcription coactivator 1	Mus musculus	19-25
27186329-3	2016	The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013).	Arginine	39-42	RAD17 checkpoint clamp loader component	Homo sapiens	28-34
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	160-168	CREB regulated transcription coactivator 1	Mus musculus	180-186
27487210-4	2016	However, the mechanism by which the mTORC1 pathway detects and transmits this arginine signal has been elusive.	Arginine	78-86	CREB regulated transcription coactivator 1	Mus musculus	36-42
27186329-3	2016	The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013).	Arginine	39-42	RAD17 checkpoint clamp loader component	Homo sapiens	28-34
27487210-6	2016	Homodimeric CASTOR1 binds arginine at the interface of two Aspartate kinase, Chorismate mutase, TyrA (ACT) domains, enabling allosteric control of the adjacent GATOR2-binding site to trigger dissociation from GATOR2 and downstream activation of mTORC1.	Arginine	26-34	CREB regulated transcription coactivator 1	Mus musculus	245-251
27487210-7	2016	Our data reveal that CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases, suggesting that the mTORC1 pathway exploited an ancient, amino-acid-dependent allosteric mechanism to acquire arginine sensitivity.	Arginine	254-262	CREB regulated transcription coactivator 1	Mus musculus	164-170
26673964-6	2016	Moreover, we show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine.	Arginine	140-148	interleukin 4 induced 1	Homo sapiens	23-28
27487210-8	2016	Together, these results establish a structural basis for arginine sensing by the mTORC1 pathway and provide insights into the evolution of a mammalian nutrient sensor.	Arginine	57-65	CREB regulated transcription coactivator 1	Mus musculus	81-87
26826241-11	2016	Suppression of IFN-gamma production was reversed by l-arginine supplementation, consistent with increased MDSC arginase-1 activity.	Arginine	52-62	arginase 1	Homo sapiens	111-121
27221333-1	2016	Hb Savaria [alpha49(CE7)Ser Arg; HBA2: c.150C &gt; A] is a rare hemoglobin (Hb) variant, initially described in Eastern Europe but present worldwide.	Arginine	28-31	hemoglobin subunit alpha 2	Homo sapiens	33-37
26895666-3	2016	We aimed to investigate (i) expressional changes of arginine synthesizing and catabolic enzymes in human intestinal tissues of NEC, spontaneous intestinal perforation (SIP) and noninflammatory surgical conditions (Surg-CTL) and to investigate the (ii) mechanisms of arginine dysregulation and enterocyte proliferation upon stimulation by bacterial components, arginine depletion, ARG1 overexpression and nitric oxide (NO) supplementation.	Arginine	52-60	arginase 1	Homo sapiens	380-384
27104830-17	2016	These findings combined with decreased ARG1 expression indicate a pattern of dysregulated L-Arg availability and metabolism in UC.	Arginine	90-95	arginase 1	Homo sapiens	39-43
27479442-6	2016	Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours.	Arginine	187-197	arginase 1	Homo sapiens	35-39
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	aldehyde dehydrogenase 18 family member A1	Homo sapiens	69-77
27479442-6	2016	Cell surface-immobilized K6-InaK-N/ARG1 presented an arginase activity of 10.7 U/OD600 under the optimized conditions of 40 C, pH 10.0 and 1 mM Mn2+, which could convert more than 95% of L-Arginine (L-Arg) to L-Ornithine (L-Orn) in 16 hours.	Arginine	187-192	arginase 1	Homo sapiens	35-39
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	carbamoyl-phosphate synthase 1	Homo sapiens	90-94
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	ornithine aminotransferase	Homo sapiens	101-104
26901772-4	2016	We have previously reported that the protein arginine methyltransferase PRMT5 catalyzes symmetrical dimethylation of the NF-kappaB subunit p65 in EC at multiple arginine residues.	Arginine	45-53	RELA proto-oncogene, NF-kB subunit	Homo sapiens	139-142
27231350-4	2016	These three alternative PGC-1alpha isoforms lack the arginine/serine-rich (RS) and RNA recognition motifs characteristic of PGC-1alpha1.	Arginine	53-61	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	24-34
27129265-7	2016	This stands in stark contrast to cationic trypsinogen where single mutations of either Leu-81 or Arg-122 resulted in almost complete resistance to CTRC-mediated degradation.	Arginine	97-100	serine protease 1	Homo sapiens	33-53
26538093-3	2016	The PRNT gene-coding region was analyzed by single-strand conformation polymorphism and sequencing, allowing the identification of the first ovine PRNT polymorphisms, in codons 6, 38, 43 and 48: c.17C&gt;T (p.Ser6Phe, which disrupts a consensus arginine-X-X-serine/threonine motif); c.112G&gt;C (p.Gly38&gt;Arg); c.129T&gt;C and c.144A&gt;G (synonymous) respectively.	Arginine	307-310	prion protein (testis specific)	Ovis aries	4-8
27043409-5	2016	Mechanistically, inhibition of Arg1 enzymatic activity disrupted multiple components of ILC2 metabolic programming by altering arginine catabolism, impairing polyamine biosynthesis and reducing aerobic glycolysis.	Arginine	127-135	arginase, liver	Mus musculus	31-35
26538093-3	2016	The PRNT gene-coding region was analyzed by single-strand conformation polymorphism and sequencing, allowing the identification of the first ovine PRNT polymorphisms, in codons 6, 38, 43 and 48: c.17C&gt;T (p.Ser6Phe, which disrupts a consensus arginine-X-X-serine/threonine motif); c.112G&gt;C (p.Gly38&gt;Arg); c.129T&gt;C and c.144A&gt;G (synonymous) respectively.	Arginine	307-310	prion protein (testis specific)	Ovis aries	147-151
25846259-7	2016	0.05 mm L-Arg stimulated myogenin gene expression but also depressed muscle cell viability.	Arginine	8-13	myogenin	Gallus gallus	25-33
27161771-6	2016	The mutation (FV Leiden) predicts the Arg(506) Gln replacement, which impairs the normal regulation of FVa by APC, as the Arg506 site is an important APC cleavage site.	Arginine	38-41	APC regulator of WNT signaling pathway	Homo sapiens	110-113
27161771-6	2016	The mutation (FV Leiden) predicts the Arg(506) Gln replacement, which impairs the normal regulation of FVa by APC, as the Arg506 site is an important APC cleavage site.	Arginine	38-41	APC regulator of WNT signaling pathway	Homo sapiens	150-153
25846259-8	2016	L-NAME blocked the effect of 0.05 mm L-Arg on myogenin mRNA levels when co-incubated with 0.05 mm L-Arg.	Arginine	37-42	myogenin	Gallus gallus	46-54
26832332-5	2016	The 57th amino acid, highly conserved between B-Tat (arginine) and C-Tat (serine), is located in the basic domain of Tat, and played an important role in this subcellular localization.	Arginine	53-61	tyrosine aminotransferase	Homo sapiens	48-51
26832332-5	2016	The 57th amino acid, highly conserved between B-Tat (arginine) and C-Tat (serine), is located in the basic domain of Tat, and played an important role in this subcellular localization.	Arginine	53-61	tyrosine aminotransferase	Homo sapiens	69-72
25846259-8	2016	L-NAME blocked the effect of 0.05 mm L-Arg on myogenin mRNA levels when co-incubated with 0.05 mm L-Arg.	Arginine	98-103	myogenin	Gallus gallus	46-54
26832332-5	2016	The 57th amino acid, highly conserved between B-Tat (arginine) and C-Tat (serine), is located in the basic domain of Tat, and played an important role in this subcellular localization.	Arginine	53-61	tyrosine aminotransferase	Homo sapiens	69-72
26601957-9	2016	These data provide new evidence demonstrating that amino acid sequence Leu(480)-Gln(481): 1) is crucial for proper recognition of the fVa-dependent site(s) for fXa within prothrombinase on FII, required for efficient initial cleavage of FII at Arg(320); and 2) is compulsory for appropriate tethering of fV, fVIII, and protein C required for their timely activation by IIa.	Arginine	244-247	coagulation factor VIII	Homo sapiens	308-313
26669414-9	2016	Site-directed mutagenesis experiments revealed that the enzymatic reaction involves a PLP-linked ketimine intermediate and uses an arginine residue from the C-terminus of each isomerase to epimerize the amino acid beta-position.	Arginine	131-139	pyridoxal phosphatase	Homo sapiens	86-89
27015302-1	2016	The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood.	Arginine	150-158	CREB regulated transcription coactivator 1	Mus musculus	24-30
27015302-3	2016	identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.	Arginine	29-37	CREB regulated transcription coactivator 1	Mus musculus	94-100
26449889-4	2016	Here, we show that activation via CD3 and CD28 induces arginine transport into primary human T cells.	Arginine	55-63	CD28 molecule	Homo sapiens	42-46
26776670-3	2016	AhR-G1661A single nucleotide polymorphism (SNP: rs2066853) causes an arginine to lysine substitution in the acidic sub-domain of TAD at position 554 (R554K).	Arginine	69-77	aryl hydrocarbon receptor	Homo sapiens	0-3
26381755-0	2016	Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes.	Arginine	0-8	ubiquitin associated protein 2 like	Homo sapiens	24-59
26797131-0	2016	Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity.	Arginine	51-59	nuclear speckle splicing regulatory protein 1	Homo sapiens	0-34
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	nuclear speckle splicing regulatory protein 1	Homo sapiens	30-64
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	nuclear speckle splicing regulatory protein 1	Homo sapiens	66-72
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	serine and arginine rich splicing factor 2	Homo sapiens	237-242
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	serine and arginine rich splicing factor 2	Homo sapiens	244-248
26797131-7	2016	Deletion of the first arginine/serine-rich-like region (RS1) completely abrogated binding to the SR proteins and to target mRNA and also failed to induce splicing of CD44 exon v5, suggesting that RS1 is critical for NSrp70 functioning.	Arginine	22-30	retinoschisin 1	Homo sapiens	56-59
26381755-7	2016	UBAP2L has an arginine- and glycine-rich motif called the RGG/RG or GAR motif in the N terminus.	Arginine	14-22	ubiquitin associated protein 2 like	Homo sapiens	0-6
26381755-8	2016	Biochemical analysis confirmed that arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1.	Arginine	36-44	ubiquitin associated protein 2 like	Homo sapiens	77-83
26381755-10	2016	Our results show a possible role for arginine methylation in UBAP2L for the progression of mitosis.	Arginine	37-45	ubiquitin associated protein 2 like	Homo sapiens	61-67
26763441-0	2016	MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCdelta/p38delta Signaling.	Arginine	47-55	protein kinase C delta	Homo sapiens	92-100
27031716-10	2016	L-Arg at low doses positively modulated MMP-9 activity that promoted tumor progression.	Arginine	0-5	matrix metallopeptidase 9	Mus musculus	40-45
26763441-9	2016	We propose that PRMT5/MEP50-dependent methylation is an epigenetic mechanism that assists in silencing of hINV expression, and that PKCdelta signaling activates gene expression by directly activating transcription and by suppressing PRMT5/MEP50-dependent arginine dimethylation of promoter-associated histones.	Arginine	255-263	protein kinase C delta	Homo sapiens	132-140
26583619-4	2016	The mother was heterozygous for the HbA2" delta-globin mutation (delta16 (A13) Gly   Arg), thus beta-thalassemia trait was unrecognized due to coinheritance of HbA2".	Arginine	85-88	hemoglobin subunit alpha 2	Homo sapiens	36-40
26911616-6	2016	Complement sequencing subsequently revealed a potential causative mutation in exon 12 of complement factor B with changes of lysine at amino acid position 533 to an arginine (CFB p.K533R).	Arginine	165-173	complement factor B	Homo sapiens	89-108
26912860-3	2016	The crystal structure of the Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to a ubiquitinated nucleosome reveals that the DUB module primarily contacts H2A/H2B, with an arginine cluster on the Sgf11 zinc finger domain docking on the conserved H2A/H2B acidic patch.	Arginine	162-170	ENY2 transcription and export complex 2 subunit	Homo sapiens	40-44
27110069-5	2016	The results showed that arginine reduced the LPS-induced production like IL-1beta, IL-6, TNF-alpha, and iNOS.	Arginine	24-32	interleukin 1 beta	Bos taurus	73-81
26403849-4	2016	The widely expressed SLC25A2 transported ADMA across the liposomal membrane in both directions by both unidirectional transport and exchange against arginine or lysine.	Arginine	149-157	solute carrier family 25 member 2	Homo sapiens	21-28
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Arginine	45-55	arginase 1	Homo sapiens	0-10
26475291-1	2016	Arginase 1 (Arg1) limits the availability of l-arginine for producing nitric oxide (NO) and ornithine, a substrate for polyamine synthesis.	Arginine	45-55	arginase 1	Homo sapiens	12-16
26833727-6	2016	The consensus C:G base pairs H-bond with conserved His or Arg residues in ZnF8, ZnF9, and ZnF11, and the consensus T:A base pair H-bonds with an Asn that replaces His in ZnF10.	Arginine	58-61	zinc finger protein 8	Homo sapiens	74-78
26742086-0	2016	Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.	Arginine	39-47	Ras homolog, mTORC1 binding	Homo sapiens	16-20
26742086-0	2016	Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.	Arginine	39-47	CREB regulated transcription coactivator 1	Mus musculus	58-64
26742086-3	2016	Arginine, an amino acid essential during mammalian embryogenesis and early development is one of the key activators of mTORC1.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	119-125
26742086-4	2016	Herein, we demonstrate that arginine acts independently of its metabolism to allow maximal activation of mTORC1 by growth factors via a mechanism that does not involve regulation of mTORC1 localization to lysosomes.	Arginine	28-36	CREB regulated transcription coactivator 1	Mus musculus	105-111
26742086-5	2016	Instead, arginine specifically suppresses lysosomal localization of the TSC complex and interaction with its target small GTPase protein, Rheb.	Arginine	9-17	Ras homolog, mTORC1 binding	Homo sapiens	138-142
26742086-6	2016	By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC.	Arginine	38-46	Ras homolog, mTORC1 binding	Homo sapiens	24-28
26742086-6	2016	By interfering with TSC-Rheb complex, arginine relieves allosteric inhibition of Rheb by TSC.	Arginine	38-46	Ras homolog, mTORC1 binding	Homo sapiens	81-85
26742086-7	2016	Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	126-132
26742086-8	2016	Arginine is the main amino acid sensed by the mTORC1 pathway in several cell types including human embryonic stem cells (hESCs).	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	46-52
26742086-9	2016	Dependence on arginine is maintained once hESCs are differentiated to fibroblasts, neurons, and hepatocytes, highlighting the fundamental importance of arginine-sensing to mTORC1 signaling.	Arginine	152-160	CREB regulated transcription coactivator 1	Mus musculus	172-178
26971935-5	2016	Real-time PCR analysis revealed in APPwt cells significant decreases of ARG1 and ARG2 which are responsible for lysing arginine into ornithine and urea; this reduction was followed by significantly lower enzyme activity.	Arginine	119-127	arginase 1	Homo sapiens	72-76
26637456-7	2016	Mutations of the arginine/serine (SR) di-repeats within the intrinsically disordered amino terminus of NP1 are required for splicing of the capsid transcript but not suppression of polyadenylation at (pA)p. 3"-end processing of MVC mRNAs at (pA)p is critical for viral genome replication and the optimal expression of NP1 and NS1.	Arginine	17-25	NP1	Canine minute virus	103-106
26637456-7	2016	Mutations of the arginine/serine (SR) di-repeats within the intrinsically disordered amino terminus of NP1 are required for splicing of the capsid transcript but not suppression of polyadenylation at (pA)p. 3"-end processing of MVC mRNAs at (pA)p is critical for viral genome replication and the optimal expression of NP1 and NS1.	Arginine	17-25	NP1	Canine minute virus	318-321
26126491-2	2015	We screened a kinase inhibitor library, using A549 cells that are transduced with a lentivirus keratin 18 (K18) construct, to identify compounds that normalize filament disruption due to K18 Arg90Cys mutation at the conserved arginine.	Arginine	226-234	keratin 18	Mus musculus	187-190
26448619-0	2015	Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.	Arginine	119-127	linker for activation of T cells family, member 2	Rattus norvegicus	157-161
26448619-2	2015	Previously we showed that ammonia increases arginine (Arg) uptake in cultured rat cortical astrocytes specifically via y(+)L amino acid transport system, by activation of its member, a heteromeric y(+)LAT2 transporter.	Arginine	44-52	linker for activation of T cells family, member 2	Rattus norvegicus	201-205
26448619-2	2015	Previously we showed that ammonia increases arginine (Arg) uptake in cultured rat cortical astrocytes specifically via y(+)L amino acid transport system, by activation of its member, a heteromeric y(+)LAT2 transporter.	Arginine	54-57	linker for activation of T cells family, member 2	Rattus norvegicus	201-205
26448619-9	2015	Ammonia (NH4(+)) increases the expression and activity of the L-arginine (Arg) transporter (Arg/neutral amino acids [NAA] exchanger) y(+)LAT2 in cultured rat cortical astrocytes by a mechanism involving activation (nuclear translocation) of the transcription factor nuclear factor-Nuclear factor-kappaB (Nf-kappaB-p65).	Arginine	74-77	linker for activation of T cells family, member 2	Rattus norvegicus	137-141
26467175-2	2015	This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ornithine and urea.	Arginine	197-205	arginase, liver	Mus musculus	94-98
26308373-1	2015	The serine/arginine-rich splicing actor 4 (SRSF4) is essential for pre-mRNA splicing and can influence alternative-splice-site choice.	Arginine	11-19	serine and arginine-rich splicing factor 4	Mus musculus	43-48
26555242-3	2015	The cDNA sequence of DQA1*01:07 is nearly identical to DQA1*01:04 except for a variant at position 304, which results in the replacement of an arginine with a cysteine at 79alpha.	Arginine	143-151	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	21-25
26555242-3	2015	The cDNA sequence of DQA1*01:07 is nearly identical to DQA1*01:04 except for a variant at position 304, which results in the replacement of an arginine with a cysteine at 79alpha.	Arginine	143-151	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	55-59
26575481-12	2015	Using quantitative PCR (qPCR), we screened for 13 antibiotic resistant gene (ARG) targets and found higher abundances of sul1 (4.13-3.44 x 102 copies/mL), dfrA (0.77-1.80 x10 copies/mL) and cfr (2.00-5.21 copies/mL) genes compared to the other ARG targets selected for this survey.	Arginine	77-80	dihydropteroate synthase	Escherichia coli	121-125
26463133-1	2015	The dual inhibitory action of the pain related peptide opiorphin (H-Gln-Arg-Phe-Ser-Arg-OH) against neutral endopeptidase (NEP) and aminopeptidase N (AP-N) was further investigated by a SAR study involving minor modifications on the polar side chains of Arg residues and glycosylation with monosaccharides at Ser.	Arginine	72-75	alanyl aminopeptidase, membrane	Homo sapiens	150-154
26554819-2	2015	We showed that arginine residues within the third intracellular loop of the human D2 dopamine receptor, which are conserved in the DOP-3 receptor in the nematode Caenorhabditis elegans, were methylated by protein arginine methyltransferase 5 (PRMT5).	Arginine	15-23	dopamine receptor D2	Homo sapiens	82-102
26554819-2	2015	We showed that arginine residues within the third intracellular loop of the human D2 dopamine receptor, which are conserved in the DOP-3 receptor in the nematode Caenorhabditis elegans, were methylated by protein arginine methyltransferase 5 (PRMT5).	Arginine	15-23	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	205-241
26554819-2	2015	We showed that arginine residues within the third intracellular loop of the human D2 dopamine receptor, which are conserved in the DOP-3 receptor in the nematode Caenorhabditis elegans, were methylated by protein arginine methyltransferase 5 (PRMT5).	Arginine	15-23	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	243-248
26458876-1	2015	Part of the "signature sequence" that defines the voltage-gated proton channel (H(V1)) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V1) genes.	Arginine	134-137	hydrogen voltage gated channel 1	Homo sapiens	80-84
26458876-1	2015	Part of the "signature sequence" that defines the voltage-gated proton channel (H(V1)) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V1) genes.	Arginine	134-137	hydrogen voltage gated channel 1	Homo sapiens	230-234
26458045-4	2015	We report multiple high-resolution human APE1-DNA structures that divulge new features of the APE1 reaction, including the metal-binding site, the nucleophile and the arginine clamps that mediate product release.	Arginine	167-175	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	41-45
26458045-4	2015	We report multiple high-resolution human APE1-DNA structures that divulge new features of the APE1 reaction, including the metal-binding site, the nucleophile and the arginine clamps that mediate product release.	Arginine	167-175	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	94-98
26422686-2	2015	Rev assembles as a homo-oligomer on the RRE using its alpha-helical arginine-rich-motif (ARM) for RNA recognition.	Arginine	68-76	Rev	Human immunodeficiency virus 1	0-3
26296888-7	2015	Moreover, the relatively weak inhibition of nNOS by Na2S in the absence of Arg and/or BH4 was markedly potentiated by the NO donor 1-(hydroxy-NNO-azoxy)-l-proline, disodium salt (IC50 ~ 1.3-2.0 10(-5) m).	Arginine	75-78	nitric oxide synthase 1	Homo sapiens	44-48
25865156-10	2015	Combination of ISO and ARG led to a decrease in cav-1 expression, a further increase in MYH7 expression and a down-regulation of MYH6 that inversely correlated with gp91phox mRNA levels.	Arginine	23-26	myosin heavy chain 7	Rattus norvegicus	88-92
26111452-0	2015	Role of an arginine-lysine rich motif in maturation and trafficking of CD19.	Arginine	11-19	CD19 molecule	Homo sapiens	71-75
26111452-3	2015	The current study explored the contribution of an arginine-lysine rich motif, present in the membrane-proximal cytoplasmic domain of CD19, for the maturation and trafficking of this molecule.	Arginine	50-58	CD19 molecule	Homo sapiens	133-137
26260792-8	2015	Mutation of the highly conserved Gln-758, which chelates a nucleotide-associated Mg(2+) ion, eliminated catalytic activity, whereas loss of the highly conserved Lys-722 and Arg-592 decreased kcat values for kinase and ATPase activities by 3-6-fold.	Arginine	173-176	dynein axonemal heavy chain 8	Homo sapiens	218-224
25948162-9	2015	Additionally, L-arginine supplementation increased L-arginine:glycine amidinotransferase activity in kidneys but not in the liver or small intestine, suggesting tissue-specific regulation of enzyme expression by L-arginine.	Arginine	14-24	glycine amidinotransferase	Rattus norvegicus	51-88
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Arginine	94-102	origin recognition complex subunit 1	Homo sapiens	6-10
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Arginine	94-102	origin recognition complex subunit 2	Homo sapiens	12-16
26972053-0	2016	The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.	Arginine	24-32	CREB regulated transcription coactivator 1	Mus musculus	49-55
26972053-3	2016	Arginine stimulation of cells activates mTORC1, but how it is sensed is not well understood.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	40-46
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	57-65	CREB regulated transcription coactivator 1	Mus musculus	107-113
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	86-94	CREB regulated transcription coactivator 1	Mus musculus	107-113
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	86-94	CREB regulated transcription coactivator 1	Mus musculus	107-113
26972053-5	2016	Here, we show that CASTOR1, a previously uncharacterized protein, interacts with GATOR2 and is required for arginine deprivation to inhibit mTORC1.	Arginine	108-116	CREB regulated transcription coactivator 1	Mus musculus	140-146
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	179-185
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	116-124	CREB regulated transcription coactivator 1	Mus musculus	179-185
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	158-166	CREB regulated transcription coactivator 1	Mus musculus	179-185
26972053-8	2016	Collectively, these results establish CASTOR1 as an arginine sensor for the mTORC1 pathway.	Arginine	52-60	CREB regulated transcription coactivator 1	Mus musculus	76-82
26650776-10	2016	CONCLUSIONS: QM/MM calculations coupled to fingerprinting analyses revealed that two Arg of AtGAPA (substituted by Gly and Val in AtGAPC1), located at 8-15 A distance from Cys149, are the major factors responsible for sulfenic acid stability, underpinning the importance of long-distance polar interactions in tuning sulfenic acid stability in native protein microenvironments.	Arginine	85-88	glyceraldehyde 3-phosphate dehydrogenase A subunit	Arabidopsis thaliana	92-98
26650776-10	2016	CONCLUSIONS: QM/MM calculations coupled to fingerprinting analyses revealed that two Arg of AtGAPA (substituted by Gly and Val in AtGAPC1), located at 8-15 A distance from Cys149, are the major factors responsible for sulfenic acid stability, underpinning the importance of long-distance polar interactions in tuning sulfenic acid stability in native protein microenvironments.	Arginine	85-88	glyceraldehyde-3-phosphate dehydrogenase C subunit 1	Arabidopsis thaliana	130-137
26983598-6	2016	Western blotting and enzymatic activity assays validated that the key enzymes ADH1C, ALDH1A1, and ALDH2, which are mainly involved in ethanol degradation pathways, were highly differentially expressed, and activated between Ctrl and +Arg in HepG2 cells.	Arginine	234-237	aldehyde dehydrogenase 2 family member	Homo sapiens	98-103
26836305-2	2016	Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multivalent interactions with proteins containing arginine-rich linear motifs (R-motifs) and ribosomal RNA (rRNA).	Arginine	160-168	nucleophosmin 1	Homo sapiens	19-32
26836305-2	2016	Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multivalent interactions with proteins containing arginine-rich linear motifs (R-motifs) and ribosomal RNA (rRNA).	Arginine	160-168	nucleophosmin 1	Homo sapiens	34-38
26403849-3	2016	It was found that the recombinant, purified mitochondrial solute carrier SLC25A2 when reconstituted into liposomes efficiently transports ADMA in addition to its known substrates arginine, lysine, and ornithine and in contrast to the other known mitochondrial amino acid transporters SLC25A12, SLC25A13, SLC25A15, SLC25A18, SLC25A22, and SLC25A29.	Arginine	179-187	solute carrier family 25 member 2	Homo sapiens	73-80
26867056-11	2016	Activated, arginine 614 (Arg614)-cleaved matriptase was not detectable in placentas.	Arginine	11-19	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	41-51
26818210-5	2016	Recently, we described a new strategy based arginine-affinity chromatography to specifically purify the recombinant pre-miR-29b.	Arginine	44-52	microRNA 29b-1	Homo sapiens	120-127
26659906-1	2016	We describe the 3D supramolecular structure of Fmoc-RGDS fibrils, where Fmoc and RGDS refer to the hydrophobic N-(fluorenyl-9-methoxycarbonyl) group and the hydrophilic Arg-Gly-Asp-Ser peptide sequence, respectively.	Arginine	169-172	ral guanine nucleotide dissociation stimulator	Homo sapiens	52-56
26659906-1	2016	We describe the 3D supramolecular structure of Fmoc-RGDS fibrils, where Fmoc and RGDS refer to the hydrophobic N-(fluorenyl-9-methoxycarbonyl) group and the hydrophilic Arg-Gly-Asp-Ser peptide sequence, respectively.	Arginine	169-172	ral guanine nucleotide dissociation stimulator	Homo sapiens	81-85
26428312-2	2016	While mediator is synthesized from L-arginine by neuronal, endothelial, and inducible nitric oxide synthases (NOS1,NOS3 and NOS2 respectively), NOS3 is the most important isoform for NO formation in the cardiovascular system.	Arginine	35-45	nitric oxide synthase 1	Homo sapiens	110-114
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Arginine	78-81	teratocarcinoma-derived growth factor 1 pseudogene 4	Homo sapiens	56-59
26872252-8	2016	A single amino acid exchange of an arginine to an alanine residue is sufficient to abolish the antagonistic effect of Gremlin-1 on MIF.	Arginine	35-43	macrophage migration inhibitory factor	Homo sapiens	131-134
27308186-2	2016	Two reported subtypes of Arg (ArgI and II) compete with nitric oxide synthase (NOS) to use L-arginine as a substrate, and subsequently regulate NOS activity.	Arginine	91-101	nitric oxide synthase 1, neuronal	Mus musculus	56-77
26715035-10	2015	Whereas several arginine residues displayed low to moderate levels of glycation (e.g., Arg93, Arg365, Arg444) Arg354 in the active centre of catalase was never found to be modified.	Arginine	16-24	catalase	Bos taurus	141-149
26519531-7	2015	In this study, we demonstrate that the leucine-rich hydrophobic sequence stretches (with the central leucine residues L20 and L66) in the first and second TM helix of TAP2 form a functional unit acting as a docking site for optimal TPN/MHC I recruitment, whereas three distinct highly conserved arginine and/or aspartate residues inside or flanking these TM helices are dispensable.	Arginine	295-303	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	167-171
26377079-8	2015	The uptake was Na+-independent, and was inhibited by L-ornithine, L-arginine, and L-lysine, suggesting the involvement of CAT1 in L-ornithine transport at the inner BRB.	Arginine	66-76	solute carrier family 7 member 1	Rattus norvegicus	122-126
26124281-2	2015	SRSF2, a member of the serine/arginine-rich (SR) family of splicing factors, is one of the mutation targets associated with poor survival in patients suffering from myelodysplastic syndromes.	Arginine	30-38	serine and arginine rich splicing factor 2	Homo sapiens	0-5
26175157-2	2015	Arg-193 and Ser-39 have been identified as contributors to the inhibitor resistance and cleavage capability of mesotrypsin, but it is not known whether these residues fully account for the unusual properties of mesotrypsin.	Arginine	0-3	serine protease 3	Homo sapiens	111-122
26175157-4	2015	We find that Arg-193 and Ser-39 are sufficient to confer mesotrypsin-like resistance to inhibition; however, compared with mesotrypsin, the trypsin-Y39S/G193R double mutant remains 10-fold slower at hydrolyzing BPTI and 2.5-fold slower at hydrolyzing APPI.	Arginine	13-16	serine protease 3	Homo sapiens	57-68
27110069-5	2016	The results showed that arginine reduced the LPS-induced production like IL-1beta, IL-6, TNF-alpha, and iNOS.	Arginine	24-32	interferon beta-2	Bos taurus	83-87
26368313-3	2015	Hence, we examined the possibility of performing gene therapy using the biodegradable polymeric non-viral vector Arginine-grafted poly (cystaminebisacrylamide-diaminohexane) (ABP)-conjugated poly (amidoamine) (PAMAM) dendrimer (PAM-ABP) in hMSCs.	Arginine	113-121	amine oxidase copper containing 1	Homo sapiens	175-178
26267306-3	2015	Herein, we show that Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an arginine methylation-dependent manner.	Arginine	115-123	apoptosis and caspase activation inhibitor	Homo sapiens	21-25
26368313-3	2015	Hence, we examined the possibility of performing gene therapy using the biodegradable polymeric non-viral vector Arginine-grafted poly (cystaminebisacrylamide-diaminohexane) (ABP)-conjugated poly (amidoamine) (PAMAM) dendrimer (PAM-ABP) in hMSCs.	Arginine	113-121	amine oxidase copper containing 1	Homo sapiens	232-235
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	9-17	T-box transcription factor 1	Homo sapiens	4-7
26234632-9	2015	The N-terminal domain is less likely to be associated with UDP-sugar selectivity, although, a conserved residue, Arg-259 (UGT2B7 numbering) in the UGT 1 and 2 families may influence UDP-sugar selectivity.	Arginine	113-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	147-158
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	9-17	titin	Homo sapiens	107-110
26289097-9	2015	The N-terminal domain is less likely to be associated with UDP-sugar selectivity, although, a conserved residue, Arg-259 (UGT2B7 numbering) in the UGT 1 and 2 families may influence UDP-sugar selectivity.	Arginine	113-116	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	147-158
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	9-17	titin	Homo sapiens	205-208
25874535-13	2015	Transient overexpression of constitutively active FOXO1 in nuclear reversed the AMI-1-induced improvement of beta cell function without changing arginine methylation.	Arginine	145-153	forkhead box O1	Rattus norvegicus	50-55
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	161-169	T-box transcription factor 1	Homo sapiens	4-7
26701604-9	2015	Cga/Tga (arginine/nonsense-R/*) transitional change at CpG mutation hotspots was the most frequent type of TTN nonsense mutation accounting for 91.3% (21/23) of arginine residue nonsense mutation (R/*) at TTN A-band region.	Arginine	161-169	titin	Homo sapiens	107-110
26411433-3	2015	In this paper, we identified several alternative physiological roles of supplemental GAA, including the stimulation of hormonal release and neuromodulation, an alteration of metabolic utilization of arginine, and an adjustment of oxidant-antioxidant status.	Arginine	199-207	alpha glucosidase	Homo sapiens	85-88
25937317-3	2015	Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg.	Arginine	81-89	plasminogen	Homo sapiens	143-146
26034040-12	2015	USF1 complexes containing the histone H3 asymmetrically dimethylated on Arg-17 signature of PRMT4 are increased with LRP6-VKO.	Arginine	72-75	coactivator-associated arginine methyltransferase 1	Mus musculus	92-97
25817040-9	2015	We also, for the first time characterized a functional mutation of HEF1 on Arg-367 which mimics the effect of Ser-369 to Ala mutation.	Arginine	75-78	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	67-71
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Arginine	62-72	arginase 1	Homo sapiens	0-10
26599209-0	2015	IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.	Arginine	113-121	interleukin 4 induced 1	Homo sapiens	0-5
26358771-1	2015	Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine.	Arginine	100-108	arginase 1	Homo sapiens	47-57
26358771-1	2015	Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine.	Arginine	100-108	arginase 1	Homo sapiens	59-63
26358771-7	2015	We tested whether one of these enzymes, a pegylated human recombinant arginase 1 (AEB1102), reduces plasma arginine in murine models of arginase deficiency.	Arginine	107-115	arginase 1	Homo sapiens	70-80
26545110-3	2015	To experimentally address this question, we performed synthetic genetic array (SGA) analysis with a ubiquitination-deficient K164 to arginine (K164R) mutant of PCNA against a library of S. cerevisiae temperature-sensitive alleles.	Arginine	133-141	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	160-164
26520372-8	2015	The remaining copy of Sfpi1 has a point mutation in the coding sequence for the DNA-binding domain of the protein in 70% of rAML, which alters a single CpG sequence in the codon for arginine residue R235.	Arginine	182-190	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	22-27
27066566-5	2015	RESULTS: Previous studies suggest that neuropathy-causing mutations occur primarily at arginine residues on the convex face of the TRPV4 ankyrin repeat domain (ARD).	Arginine	87-95	transient receptor potential cation channel subfamily V member 4	Homo sapiens	131-136
26466095-8	2015	Moreover, the hRpn2-derived peptide was no longer able to interact with endogenous hRpn13 when a strictly conserved phenylalanine (F948 in humans) was replaced with arginine or a stop codon, or when Y950 and I951 were substituted with aspartic acid.	Arginine	165-173	ribophorin II	Homo sapiens	14-19
25934511-11	2015	Baseline arginine/ADMA ratio correlated with baseline mRAP (r=-0.79; P=0.002).	Arginine	9-17	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	54-58
26047835-8	2015	In the MCF-7 and MG-63 cells, PPE or Arg significantly increased the cell proliferation, estrogen receptor beta mRNA expression, and estrogen-response elements luciferase activity.	Arginine	37-40	estrogen receptor 2	Homo sapiens	89-111
26425661-3	2015	Recent studies suggest that PRMT5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin D1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis.	Arginine	152-160	cyclin D1	Homo sapiens	108-117
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Arginine	93-96	serine protease 3	Homo sapiens	39-50
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Arginine	93-96	serine protease 3	Homo sapiens	152-163
25953850-8	2015	Arg(432) and Arg(434) in domain V of MARCO are required for the polarization of macrophages to a profibrotic phenotype as mutation of these residues reduced FIZZ1 expression (17-fold) compared with cells expressing MARCO.	Arginine	0-3	macrophage receptor with collagenous structure	Mus musculus	37-42
25953850-8	2015	Arg(432) and Arg(434) in domain V of MARCO are required for the polarization of macrophages to a profibrotic phenotype as mutation of these residues reduced FIZZ1 expression (17-fold) compared with cells expressing MARCO.	Arginine	0-3	macrophage receptor with collagenous structure	Mus musculus	215-220
25953850-8	2015	Arg(432) and Arg(434) in domain V of MARCO are required for the polarization of macrophages to a profibrotic phenotype as mutation of these residues reduced FIZZ1 expression (17-fold) compared with cells expressing MARCO.	Arginine	13-16	macrophage receptor with collagenous structure	Mus musculus	37-42
26547715-8	2015	A novel substitution in IL2RG: c.675 C&gt;A, leading to p.225 Ser&gt;Arg was found.	Arginine	69-72	interleukin 2 receptor subunit gamma	Homo sapiens	24-29
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Arginine	39-42	protein phosphatase 5 catalytic subunit	Homo sapiens	67-70
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Arginine	133-136	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
26190207-3	2015	We found that, unlike previous report, Arg 100 contributes less to PP5-inhibitor binding, and the residues His 69, Asn 128, His 129, Arg 225, His 252 and Arg 250 are of importance to PP5-inhibitor binding.	Arginine	133-136	protein phosphatase 5 catalytic subunit	Homo sapiens	183-186
25109415-15	2015	Patients with at least one missense mutation in SLC3A1 had significantly lower levels of lysine, arginine, and ornithine but not cystine than patients with all other combinations of mutations.	Arginine	97-105	solute carrier family 3 member 1	Homo sapiens	48-54
25958845-4	2015	Augmentation of endothelium-specific l-arginine transport via CAT1 can attenuate pressure-overload-dependent cardiac hypertrophy and fibrosis.	Arginine	37-47	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	62-66
26236104-7	2015	A lower l-arginine concentration at early gestation (&lt;70 microM) significantly elevated PIH risk [adjusted odds ratio (OR) = 4.26, 95% CI 1.29-14.50].	Arginine	8-18	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	91-94
26236104-9	2015	In conclusion, a lower l-arginine concentration at early gestation, overweight before pregnancy (BMI&gt;25 kg/m(2)) and primipara could predict to the development of PIH.	Arginine	23-33	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	166-169
26035438-1	2015	Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site.	Arginine	13-23	nitric oxide synthase 1	Homo sapiens	56-67
26035438-1	2015	Oxidation of L-arginine (L-Arg) to nitric oxide (NO) by NO synthase (NOS) takes place at the heme active site.	Arginine	25-30	nitric oxide synthase 1	Homo sapiens	56-67
26035438-4	2015	In this work, pulsed electron-nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous-NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates.	Arginine	214-219	nitric oxide synthase 1	Homo sapiens	165-177
26035438-4	2015	In this work, pulsed electron-nuclear double resonance (ENDOR) spectroscopy was used to probe the hydrogen bonding of the NO ligand in the ferrous-NO heme center of neuronal NOS (nNOS) without a substrate and with L-Arg or N-hydroxy-L-arginine (NOHA) substrates.	Arginine	214-219	nitric oxide synthase 1	Homo sapiens	179-183
26035438-5	2015	Unexpectedly, no H-bonding interaction connecting the NO ligand to the active site water molecule or the Arg substrate was detected, in contrast to the results obtained by X-ray crystallography for the Arg-bound nNOS heme domain [Li et al.	Arginine	202-205	nitric oxide synthase 1	Homo sapiens	212-216
26035438-10	2015	The nearby exchangeable proton in both the no-substrate and Arg-containing nNOS samples is located outside the H-bonding range and, on the basis of the obtained structural constraints, can belong to the active site water (or OH).	Arginine	60-63	nitric oxide synthase 1	Homo sapiens	75-79
25918018-0	2015	A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.	Arginine	12-20	NEDD8 ubiquitin like modifier	Homo sapiens	33-38
25918018-7	2015	Replacement of this residue with arginine almost completely eliminates the conjugation of NEDD8 to its substrates.	Arginine	33-41	NEDD8 ubiquitin like modifier	Homo sapiens	90-95
25797592-4	2015	A strong correlation was also observed between HM and mRNA expression levels of arginase 1, an enzyme that catalyzes the conversion of arginine to ornithine.	Arginine	135-143	arginase 1	Homo sapiens	80-90
26068232-2	2015	In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphate synthetase 1 (CPS1) in the urea cycle.	Arginine	58-66	carbamoyl-phosphate synthase 1	Homo sapiens	197-201
25878251-1	2015	Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36) Ser(37) reveal a tethered ligand that binds to the cleaved receptor.	Arginine	64-67	F2R like trypsin receptor 1	Homo sapiens	53-59
25990308-5	2015	miR-21 deficiency protects against caerulein- or L-arginine-induced acute pancreatitis in mice.	Arginine	49-59	microRNA 21a	Mus musculus	0-6
25748791-0	2015	PRMT1-mediated arginine methylation controls ATXN2L localization.	Arginine	15-23	ataxin 2 like	Homo sapiens	45-51
25748791-2	2015	Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2.	Arginine	52-60	ataxin 2 like	Homo sapiens	76-89
25748791-2	2015	Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2.	Arginine	52-60	ataxin 2 like	Homo sapiens	91-97
25874809-1	2015	Nitric oxide synthase (NOS) catalyzes the conversion of l-arginine to l-citrulline and the second messenger nitric oxide.	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	0-21
25811613-2	2015	Here, a micellar system employing TfR-specific 7peptide (histidine-alanine-isoleucine-tyrosine- proline-arginine-histidine, HAIYPRH, 7pep) as the targeting moiety was constructed; and its endocytosis, intracellular trafficking as well as influence on TfR expression and in vivo tumor targeting were explored in the MCF-7 tumor model.	Arginine	104-112	transferrin receptor	Homo sapiens	34-37
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	vinculin	Homo sapiens	210-218
25800434-0	2015	Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides.	Arginine	10-18	tyrosine aminotransferase	Homo sapiens	77-80
25800434-3	2015	The basic region (residues 47-57) of the Tat protein contains six Arg residues, and is responsible for two biological functions: RNA recognition and cellular uptake.	Arginine	66-69	tyrosine aminotransferase	Homo sapiens	41-44
25800434-4	2015	In this study, we explore the effect of three different methylation states at each Arg residue in Tat-derived peptides on the two biological functions.	Arginine	83-86	tyrosine aminotransferase	Homo sapiens	98-101
25800434-11	2015	Upon Arg methylation, the cellular uptake of Tat-derived peptides mostly decreased.	Arginine	5-8	tyrosine aminotransferase	Homo sapiens	45-48
25800434-12	2015	Interestingly, cellular uptake of Tat-derived peptides with a single asymmetrically dimethylated Arg residue was similar to the native all Arg peptide (at 120 muM).	Arginine	97-100	tyrosine aminotransferase	Homo sapiens	34-37
25800434-12	2015	Interestingly, cellular uptake of Tat-derived peptides with a single asymmetrically dimethylated Arg residue was similar to the native all Arg peptide (at 120 muM).	Arginine	139-142	tyrosine aminotransferase	Homo sapiens	34-37
25751282-10	2015	RESULTS: We identified the nucleotide substitution c.109C>T in exon 3 of CPT1C, which determined the base substitution of an evolutionarily conserved Cys residue for an Arg in the gene product.	Arginine	169-172	carnitine palmitoyltransferase 1C	Homo sapiens	73-78
25680754-4	2015	Structural analysis demonstrated that human alpha2C-AR has a high number of arginine residues in the third intracellular loop and in the C-terminus, organized as putative RXR motifs.	Arginine	76-84	adrenoceptor alpha 2C	Homo sapiens	44-54
25680754-8	2015	In rat alpha2C-AR, the arginine cluster from the third intracellular loop is shifted to the left due to three missing residues.	Arginine	23-31	adrenoceptor alpha 2C	Rattus norvegicus	7-17
25708986-1	2015	OBJECTIVE: Tissue plasminogen activator (tPA) is administered to acute ischemic stroke victims in a vehicle formulation containing high concentrations of L-arginine (3.5g/100mg vial), a well-known nitric oxide synthase (NOS) substrate and precursor to nitric oxide (NO), as well as an enhancer of cerebral blood flow.	Arginine	154-164	nitric oxide synthase, brain	Oryctolagus cuniculus	197-218
25801886-1	2015	Anti-citrullinated protein antibodies (ACPA) are a family of rheumatoid arthritis (RA)-specific autoantibodies that recognize the amino acid citrulline, resulting from the post-translational modification of arginine.	Arginine	207-215	proteinase 3	Homo sapiens	39-43
25636591-0	2015	Improvement of the physical performance is associated with activation of NO/PGC-1alpha/mtTFA signaling pathway and increased protein expressions of electron transport chain in gastrocnemius muscle from rats supplemented with L-arginine.	Arginine	225-235	transcription factor A, mitochondrial	Rattus norvegicus	87-92
25636591-10	2015	KEY FINDINGS: 8-week l-arginine supplementation associated with physical training was effective in promoting greater tolerance to exercise that was accompanied by up-regulation of the protein expressions of mtTFA, PGC-1alpha, ATP synthase subunit c, COXIV, Cu/Zn-SOD and Mn-SOD.	Arginine	21-31	transcription factor A, mitochondrial	Rattus norvegicus	207-212
25561730-4	2015	Here, using chimeric and point-mutated GLP1R, we determined that the evolutionarily conserved amino acid residue Arg(380) flanked by hydrophobic Leu(379) and Phe(381) in extracellular loop 3 (ECL3) may have an interaction with Asp(9) and Gly(4) of the GLP-1 peptide.	Arginine	113-116	glucagon like peptide 1 receptor	Homo sapiens	39-44
25540195-10	2015	Arg greatly potentiates cofilin severing of actin filaments, and cortactin attenuates this enhanced severing.	Arginine	0-3	cofilin 1	Homo sapiens	24-31
25489882-2	2015	However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability.	Arginine	59-67	nitric oxide synthase 1	Homo sapiens	29-33
25620702-5	2015	c-Abl/Arg regulates cellular proteasome abundance by controlling the PSMA7 subunit supply.	Arginine	6-9	proteasome 20S subunit alpha 7	Homo sapiens	69-74
25620702-6	2015	Downregulated PSMA7 level results in decreased proteasome abundance in c-Abl/Arg RNAi-knockdown or c-abl/arg-deficient cells, which demonstrated an increased sensitivity to proteasome inhibition.	Arginine	105-108	proteasome 20S subunit alpha 7	Homo sapiens	14-19
25569455-5	2015	Acetylation-defective c-MYC Lys Arg substitution mutants are impaired for oncogenic transformation with p30(II) in c-myc(-/-) HO15.19 fibroblasts.	Arginine	32-35	centromere protein V	Homo sapiens	104-107
26250893-3	2015	The aim of this study was to longitudinally investigate the TREM-1 expression on peripheral blood and peritoneal neutrophils and its relationship with the levels of plasma cytokines and disease severity in a mouse model of AP following injection with varying doses of L-arginine to induce mild AP (MAP) or severe AP (SAP).	Arginine	268-278	triggering receptor expressed on myeloid cells 1	Mus musculus	60-66
25927346-0	2015	PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington"s disease (HD).	Arginine	26-34	huntingtin	Homo sapiens	73-83
25927346-2	2015	Here, we explored a functional interaction of Htt with protein arginine methyltransferase 5 (PRMT5), an enzyme mediating symmetrical dimethylation of arginine (sDMA) of key cellular proteins, including histones, and spliceosomal Sm proteins.	Arginine	63-71	huntingtin	Homo sapiens	46-49
25927346-9	2015	These studies revealed a potential new mechanism for disruption of gene expression and RNA processing in HD, involving a loss of normal function of Htt in facilitation of PRMT5, supporting the idea that epigenetic regulation of gene transcription may be involved in HD and highlighting symmetric dimethylation of arginine as potential new therapeutic target.	Arginine	313-321	huntingtin	Homo sapiens	148-151
25621140-0	2015	Case of aniridia with a heterozygous PAX6 mutation in which the glucagon response to arginine was evaluated.	Arginine	85-93	paired box 6	Homo sapiens	37-41
26639850-4	2015	The concentrations of plasma growth hormone (GH) and fractional rates of protein synthesis in the brains increased significantly with the 20% casein+0.7% arginine diet and still more with the 20% casein+0.7% ornithine diet compared with the 20% casein diet alone.	Arginine	154-162	gonadotropin releasing hormone receptor	Rattus norvegicus	29-43
26639850-4	2015	The concentrations of plasma growth hormone (GH) and fractional rates of protein synthesis in the brains increased significantly with the 20% casein+0.7% arginine diet and still more with the 20% casein+0.7% ornithine diet compared with the 20% casein diet alone.	Arginine	154-162	gonadotropin releasing hormone receptor	Rattus norvegicus	45-47
26639850-7	2015	The results suggest that the treatment with arginine is likely to increase the concentrations of GH and the rate of brain protein synthesis in rats, and that the effects of arginine on brain protein synthesis and GH concentration were lower than that of ornithine.	Arginine	44-52	gonadotropin releasing hormone receptor	Rattus norvegicus	97-99
26639850-7	2015	The results suggest that the treatment with arginine is likely to increase the concentrations of GH and the rate of brain protein synthesis in rats, and that the effects of arginine on brain protein synthesis and GH concentration were lower than that of ornithine.	Arginine	173-181	gonadotropin releasing hormone receptor	Rattus norvegicus	213-215
25348716-0	2015	PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation.	Arginine	15-23	E2F transcription factor 1 L homeolog	Xenopus laevis	110-115
25348716-8	2015	Together, our results suggest that arginine methylation negatively regulates the tumor suppressor function of pRb during cell cycle control, in part by creating a better substrate for Cdk complex phosphorylation and disrupting the interaction of pRb with E2F-1.	Arginine	35-43	E2F transcription factor 1 L homeolog	Xenopus laevis	255-260
25307852-7	2015	As sequence alignments show that this newly discovered active site Arg is well conserved among "Gln-type" CDO enzymes, we conclude that the "Gln-type" CDO homologs are not authentic CDOs but will have substrate specificity more similar to 3-mercaptopropionate dioxygenases.	Arginine	67-70	cysteine dioxygenase type 1	Rattus norvegicus	106-109
25307852-7	2015	As sequence alignments show that this newly discovered active site Arg is well conserved among "Gln-type" CDO enzymes, we conclude that the "Gln-type" CDO homologs are not authentic CDOs but will have substrate specificity more similar to 3-mercaptopropionate dioxygenases.	Arginine	67-70	cysteine dioxygenase type 1	Rattus norvegicus	151-154
25501750-9	2014	Moreover, L-ARG increased MMP-2 expression in addition to its protein content while decreasing expression of PAI-1.	Arginine	10-15	matrix metallopeptidase 2	Rattus norvegicus	26-31
25429397-6	2014	Also, the p53(Arg) compared with p53(Pro) displays higher affinity to and activates the promoter region of SAM-pointed domain-containing Ets-like factor (SPDEF), a driver of mucous differentiation.	Arginine	14-17	SAM pointed domain containing ets transcription factor	Mus musculus	107-152
25429397-6	2014	Also, the p53(Arg) compared with p53(Pro) displays higher affinity to and activates the promoter region of SAM-pointed domain-containing Ets-like factor (SPDEF), a driver of mucous differentiation.	Arginine	14-17	SAM pointed domain containing ets transcription factor	Mus musculus	154-159
25367122-4	2014	Arginine 74 is the structural equivalent of arginine 186 found in human galectin-3.	Arginine	0-8	galectin 3	Homo sapiens	72-82
25367122-4	2014	Arginine 74 is the structural equivalent of arginine 186 found in human galectin-3.	Arginine	44-52	galectin 3	Homo sapiens	72-82
25187518-9	2014	The mitochondrial translocation of GSK-3beta was attenuated also when Lys-15, but not Arg-4 or Arg-6, in the N-terminal domain of GSK-3beta was replaced with alanine.	Arginine	86-89	glycogen synthase kinase 3 beta	Homo sapiens	35-44
25187518-9	2014	The mitochondrial translocation of GSK-3beta was attenuated also when Lys-15, but not Arg-4 or Arg-6, in the N-terminal domain of GSK-3beta was replaced with alanine.	Arginine	95-98	glycogen synthase kinase 3 beta	Homo sapiens	35-44
25333616-6	2014	Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism.	Arginine	10-18	citrate synthase	Mus musculus	169-185
25333616-6	2014	Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism.	Arginine	10-18	citrate synthase	Mus musculus	187-189
24913445-7	2014	To confirm this interaction experimentally, we tested the ability of 26RFa and Arg-modified 26RFa analogues to activate the wild-type and the Q125A mutant receptors transiently expressed in CHO cells.	Arginine	79-82	pyroglutamylated RFamide peptide	Homo sapiens	92-97
24913445-9	2014	Moreover, asymmetric dimethylation of the side chain of arginine led to a 26RFa analogue, [ADMA(25) ]26RFa(20-26) , that was unable to activate the wild-type GPR103, but antagonized 26RFa-evoked [Ca(2+) ]i increase.	Arginine	56-64	pyroglutamylated RFamide peptide	Homo sapiens	74-79
24913445-9	2014	Moreover, asymmetric dimethylation of the side chain of arginine led to a 26RFa analogue, [ADMA(25) ]26RFa(20-26) , that was unable to activate the wild-type GPR103, but antagonized 26RFa-evoked [Ca(2+) ]i increase.	Arginine	56-64	pyroglutamylated RFamide peptide	Homo sapiens	101-106
24913445-9	2014	Moreover, asymmetric dimethylation of the side chain of arginine led to a 26RFa analogue, [ADMA(25) ]26RFa(20-26) , that was unable to activate the wild-type GPR103, but antagonized 26RFa-evoked [Ca(2+) ]i increase.	Arginine	56-64	pyroglutamylated RFamide peptide receptor	Homo sapiens	158-164
24913445-9	2014	Moreover, asymmetric dimethylation of the side chain of arginine led to a 26RFa analogue, [ADMA(25) ]26RFa(20-26) , that was unable to activate the wild-type GPR103, but antagonized 26RFa-evoked [Ca(2+) ]i increase.	Arginine	56-64	pyroglutamylated RFamide peptide	Homo sapiens	101-106
24913445-10	2014	CONCLUSION AND IMPLICATIONS: Altogether, these data provide strong evidence for a functional interaction between the Arg(25) residue of 26RFa and the Gln(125) residue of GPR103 upon ligand-receptor activation, which can be exploited for the rational design of potent GPR103 agonists and antagonists.	Arginine	117-120	pyroglutamylated RFamide peptide	Homo sapiens	136-141
24913445-10	2014	CONCLUSION AND IMPLICATIONS: Altogether, these data provide strong evidence for a functional interaction between the Arg(25) residue of 26RFa and the Gln(125) residue of GPR103 upon ligand-receptor activation, which can be exploited for the rational design of potent GPR103 agonists and antagonists.	Arginine	117-120	pyroglutamylated RFamide peptide receptor	Homo sapiens	170-176
24913445-10	2014	CONCLUSION AND IMPLICATIONS: Altogether, these data provide strong evidence for a functional interaction between the Arg(25) residue of 26RFa and the Gln(125) residue of GPR103 upon ligand-receptor activation, which can be exploited for the rational design of potent GPR103 agonists and antagonists.	Arginine	117-120	pyroglutamylated RFamide peptide receptor	Homo sapiens	267-273
25416217-8	2014	The conducted study has allowed us to draw a conclusion, that including L-Arginine in the treatment protocol of COPD with concomitant IHD improves cardiohaemodynamics and allows for the better efficacy of respiratory pathology therapy.	Arginine	72-82	COPD	Homo sapiens	112-116
25416217-9	2014	Addition of L-Arginine (Tivortin, "Yuriya-Farm", Kiev) to the complex therapy of COPD with concomitant IHD results in statistically significant improvement of clinical and instrumental test results, due to the drug"s intihypoxic, antiagregational, membrane-stabilizing, antioxydant and vasodilating effect.	Arginine	12-22	COPD	Homo sapiens	81-85
25073474-7	2014	L-Leucine and L-arginine competed with levodopa across the luminal enterocyte membrane as expected for b(0,+)AT-rBAT substrates, whereas dopa-decarboxylase and cathechol-O-methyl transferase inhibitors had no effect.	Arginine	14-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	Mus musculus	103-111
24620026-10	2014	Arginine:ADMA ratios, but not arginine, were significantly and inde-pendent-ly inversely associated with lactate and angiopoietin-2.	Arginine	0-8	angiopoietin 2	Homo sapiens	117-131
25038949-7	2014	Between 18 and 39 days of age both Arg (0.5% and 1%) and Arg + Gln supplementation improved the feed conversion ratio (FCR) by 3.7%, 6.3% and 4.9%, respectively, while Gln-1% worsened it by 15%.	Arginine	35-38	FCR	Gallus gallus	119-122
25038949-7	2014	Between 18 and 39 days of age both Arg (0.5% and 1%) and Arg + Gln supplementation improved the feed conversion ratio (FCR) by 3.7%, 6.3% and 4.9%, respectively, while Gln-1% worsened it by 15%.	Arginine	57-60	FCR	Gallus gallus	119-122
24970008-14	2014	MIBG inhibited the migration and invasion of HepG2 cells, possibly through the inhibition of arginine-specific single-adenosine diphosphate ribosylation and the suppression of the protein expression of integrin alpha7beta1, FAK and PI3K and the secretion of uPA, leading to reduced invasion by HepG2 cells.	Arginine	93-101	protein tyrosine kinase 2	Homo sapiens	224-227
26852606-13	2015	Formation of the M2 phenotype is accompanied by a shift of the arginine metabolism towards arginase 1 activation and increasing production of urea, increased ATP synthesis in mitochondria and increased capture of fatty acids, increased the capture of heme iron.	Arginine	63-71	arginase 1	Homo sapiens	91-101
26103639-5	2015	Recently, we showed that oral supplementation with Ps-1 as well as its related free amino acids (L-Arg and L-Lys) enhances PROP bitterness perception, especially for PROP non-tasters who have low salivary levels of Ps-1.	Arginine	97-102	taste 2 receptor member 62 pseudogene	Homo sapiens	51-55
26103639-6	2015	Here, we show that salivary L-Arg levels are higher in PROP super-tasters compared to medium tasters and non-tasters, and that oral supplementation with free L-Arg enhances PROP bitterness intensity as well as reduces bitterness latency in a dose-dependent manner, particularly in individuals with low salivary levels of both free L-Arg and Ps-1 protein.	Arginine	158-163	taste 2 receptor member 62 pseudogene	Homo sapiens	341-345
26103639-6	2015	Here, we show that salivary L-Arg levels are higher in PROP super-tasters compared to medium tasters and non-tasters, and that oral supplementation with free L-Arg enhances PROP bitterness intensity as well as reduces bitterness latency in a dose-dependent manner, particularly in individuals with low salivary levels of both free L-Arg and Ps-1 protein.	Arginine	158-163	taste 2 receptor member 62 pseudogene	Homo sapiens	341-345
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Arginine	264-267	calcium/calmodulin dependent protein kinase ID	Homo sapiens	105-115
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Arginine	264-267	calcium/calmodulin dependent protein kinase ID	Homo sapiens	216-226
25560907-7	2015	His83, which is located in the loop region of the HSF1 DNA binding domain, was suggested to enhance the intermolecular force with Arginine 79, which helps HSF1 form a DNA-binding competent.	Arginine	130-138	heat shock transcription factor 1	Homo sapiens	50-54
25560907-7	2015	His83, which is located in the loop region of the HSF1 DNA binding domain, was suggested to enhance the intermolecular force with Arginine 79, which helps HSF1 form a DNA-binding competent.	Arginine	130-138	heat shock transcription factor 1	Homo sapiens	155-159
25873329-2	2015	ADAR2 is the main enzyme responsible for A-to-I editing in humans, and A-to-I underediting at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit B (GluR-B) is associated with the pathogenesis and invasiveness of glioma.	Arginine	112-120	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	137-165
25873329-2	2015	ADAR2 is the main enzyme responsible for A-to-I editing in humans, and A-to-I underediting at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit B (GluR-B) is associated with the pathogenesis and invasiveness of glioma.	Arginine	112-120	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	167-173
25851901-9	2015	We further show that PKCdelta/p38delta signaling suppresses MEP50 expression, leading to reduced H3/H4 arginine dimethylation at the p21(Cip1) promoter, and that this is associated with enhanced p21(Cip1) expression and reduced cell proliferation.	Arginine	103-111	protein kinase C delta	Homo sapiens	21-29
25861992-0	2015	Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.	Arginine	32-35	interleukin 5	Homo sapiens	73-76
25861992-3	2015	We herein identified a mechanism whereby the methylation of Gata3 at Arg-261 regulates the transcriptional activation of the Il5 gene in Th2 cells.	Arginine	69-72	interleukin 5	Homo sapiens	125-128
25960268-2	2015	Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both the catalytic activity and auto-phosphorylation, whereas the Histidine-to-tyrosine impairs the catalytic activity without affecting its auto-phosphorylation.	Arginine	58-66	aurora kinase A	Homo sapiens	87-95
25960268-3	2015	Comparisons of the crystal structures of wild-type (WT) and mutant Aurora A demonstrate that the impairment of the kinase activity is accounted for by (1) disruption of the regulatory spine in the His-to-Arg mutant, and (2) change in the geometry of backbones of the Asp-Phe-Gly (DFG) motif and the DFG-1 residue in the His-to-Tyr mutant.	Arginine	204-207	aurora kinase A	Homo sapiens	67-75
25955978-3	2015	The selectivity of the open HV1 channel requires an aspartate near an arginine in the selectivity filter (SF), a narrow region that dictates proton selectivity, but the mechanism of proton selectivity is unknown.	Arginine	70-78	hydrogen voltage gated channel 1	Homo sapiens	28-31
25938595-1	2015	Arginase-1 catalyzes the conversion of arginine to ornithine and urea, which is the final step of the urea cycle used to remove excess ammonia from the body.	Arginine	39-47	arginase, liver	Mus musculus	0-10
25858298-3	2015	HbA2" [delta16 (A13) Gly Arg (GGC CGC)] is a delta-chain variant that has been identified in several populations of African origin.	Arginine	25-28	hemoglobin subunit alpha 2	Homo sapiens	0-4
25765074-7	2015	Embryos cultured in 1.69mM arginine had lower SLC7A1 levels and a higher abundance of messages involved with glycolysis (hexokinase 1, hexokinase 2 and glutamic pyruvate transaminase (alanine aminotransferase) 2) and decreased expression of genes involved with blocking the tricarboxylic acid cycle (pyruvate dehydrogenase kinase, isozyme 1) and the pentose phosphate pathway (transaldolase 1).	Arginine	27-35	hexokinase 2	Homo sapiens	135-147
25878270-4	2015	Areas of hippocampal neuronal death are associated with the presence of immunosuppressive CD11c(+) microglia and extracellular arginase, resulting in arginine catabolism and reduced levels of total brain arginine.	Arginine	150-158	integrin alpha X	Mus musculus	90-95
25878270-4	2015	Areas of hippocampal neuronal death are associated with the presence of immunosuppressive CD11c(+) microglia and extracellular arginase, resulting in arginine catabolism and reduced levels of total brain arginine.	Arginine	204-212	integrin alpha X	Mus musculus	90-95
25878270-5	2015	Pharmacologic disruption of the arginine utilization pathway by an inhibitor of arginase and ornithine decarboxylase protected the mice from AD-like pathology and significantly decreased CD11c expression.	Arginine	32-40	integrin alpha X	Mus musculus	187-192
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	24-32	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	83-88
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	24-32	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	203-208
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	34-37	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	83-88
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	34-37	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	203-208
25468564-12	2015	nPer a 10 cleaved the PAR-2 derived peptide between arginine and serine residues (36R-S37) to expose PAR-2 ligand SLIGKV, as determined by LC-MS. Incubating with anti-PAR-2 cleavage antibody showed diminished cytokine secretion when treated with nPer a 10.	Arginine	52-60	F2R like trypsin receptor 1	Homo sapiens	22-27
25468564-12	2015	nPer a 10 cleaved the PAR-2 derived peptide between arginine and serine residues (36R-S37) to expose PAR-2 ligand SLIGKV, as determined by LC-MS. Incubating with anti-PAR-2 cleavage antibody showed diminished cytokine secretion when treated with nPer a 10.	Arginine	52-60	F2R like trypsin receptor 1	Homo sapiens	101-106
25468564-12	2015	nPer a 10 cleaved the PAR-2 derived peptide between arginine and serine residues (36R-S37) to expose PAR-2 ligand SLIGKV, as determined by LC-MS. Incubating with anti-PAR-2 cleavage antibody showed diminished cytokine secretion when treated with nPer a 10.	Arginine	52-60	F2R like trypsin receptor 1	Homo sapiens	101-106
25753662-6	2015	MBD2IDR also recruits the histone deacetylase core components (RbAp48, HDAC2 and MTA2) of NuRD through a critical contact region requiring two contiguous amino acid residues, Arg(286) and Leu(287).	Arginine	175-178	metastasis associated 1 family member 2	Homo sapiens	81-85
25785610-0	2015	Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.	Arginine	20-28	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	65-70
25786215-4	2015	Our detailed analysis clarified that this difference in dynamics was attributable to a difference in two basic amino acids in the alphaN helix; two arginine (Arg) residues in H3 were substituted by lysine (Lys) residues at the corresponding sites in CENP-A.	Arginine	148-156	centromere protein A	Homo sapiens	250-256
25786215-4	2015	Our detailed analysis clarified that this difference in dynamics was attributable to a difference in two basic amino acids in the alphaN helix; two arginine (Arg) residues in H3 were substituted by lysine (Lys) residues at the corresponding sites in CENP-A.	Arginine	158-161	centromere protein A	Homo sapiens	250-256
25786215-6	2015	Our exonuclease III assay consistently revealed that replacement of these two Arg residues in the H3 nucleosome by Lys enhanced endonuclease susceptibility, suggesting that the DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.	Arginine	78-81	centromere protein A	Homo sapiens	193-199
25798088-1	2015	The majority of AMPA receptors in the adult brain contain GluA2 subunits, which can be edited at the Q/R site, changing a glutamine to an arginine within the ion pore.	Arginine	138-146	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	58-63
25658355-0	2015	Proteolytic cleavage at twin arginine residues affects structural and functional transitions of lupin seed 11S storage globulin.	Arginine	29-37	5'-nucleotidase, cytosolic IIIA	Homo sapiens	96-101
25658355-3	2015	To prove this, the protein was incubated with a lupin seed endopeptidase previously shown to cleave at twin arginine motifs, recurrent in the sequence region of interest.	Arginine	108-116	5'-nucleotidase, cytosolic IIIA	Homo sapiens	48-53
25463493-3	2015	In this study, surfaces with the mobile Arg-Gly-Asp-Ser (RGDS) peptide have been constructed.	Arginine	40-43	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	57-61
25563649-8	2015	Arg(9) and Arg(14) are required for PKA recognition and phosphorylation of PLN.	Arginine	0-3	phospholamban	Homo sapiens	75-78
25563649-8	2015	Arg(9) and Arg(14) are required for PKA recognition and phosphorylation of PLN.	Arginine	11-14	phospholamban	Homo sapiens	75-78
25563649-10	2015	Hydrophobic mutations of Arg(9) cause more complex changes in function, including loss of PLN function and dominant negative interaction with SERCA in heterozygous individuals.	Arginine	25-28	phospholamban	Homo sapiens	90-93
25274782-4	2015	Asymmetric arginine methylation of FUS by the class 1 arginine methyltransferase, protein arginine methyltransferase 1 (PRMT1), regulates nucleocytoplasmic shuttling of FUS.	Arginine	11-19	fused in sarcoma	Mus musculus	35-38
25274782-4	2015	Asymmetric arginine methylation of FUS by the class 1 arginine methyltransferase, protein arginine methyltransferase 1 (PRMT1), regulates nucleocytoplasmic shuttling of FUS.	Arginine	11-19	fused in sarcoma	Mus musculus	169-172
25622152-0	2015	Interaction of L-arginine with kappa-casein and its effect on amyloid fibril formation by the protein: multi-spectroscopic approaches.	Arginine	15-25	casein kappa	Homo sapiens	31-43
25622152-1	2015	Herein, the interaction of l-arginine (ARG) with kappa-casein, and its effect on amyloid fibril formation of the protein, have been investigated in vitro by resonance light scattering (RLS), fluorescence, UV-Vis absorption spectroscopy and transmission electron microscopy (TEM) under simulated physiological conditions.	Arginine	27-37	casein kappa	Homo sapiens	49-61
25622152-1	2015	Herein, the interaction of l-arginine (ARG) with kappa-casein, and its effect on amyloid fibril formation of the protein, have been investigated in vitro by resonance light scattering (RLS), fluorescence, UV-Vis absorption spectroscopy and transmission electron microscopy (TEM) under simulated physiological conditions.	Arginine	39-42	casein kappa	Homo sapiens	49-61
25622152-2	2015	The results indicated that ARG inhibited fibril formation by reduced and carboxymethylated kappa-casein (RCMkappa-CN), and there was interaction between ARG and RCMkappa-CN, proved by the observation of enhancement in RLS intensity attributed to the formation of RCMkappa-CN-ARG complex.	Arginine	27-30	casein kappa	Homo sapiens	91-103
25406192-9	2015	MDSC induction by peg-Arg I occurred through the general control nonrepressed-2 eIF2alpha kinase.	Arginine	22-25	eukaryotic translation initiation factor 2A	Mus musculus	80-89
25493385-10	2015	AT1 expression increased in the 2K1C compared with the Sham, ALSK and ALSK+L-arg groups, AT2 expression increased in the ALSK+L-arg group compared with the Sham and L-arg groups, and gp91phox decreased in the ALSK+L-arg group compared with the 2K1C and ALSK groups.	Arginine	75-80	angiotensin II receptor, type 1a	Rattus norvegicus	0-3
25493385-10	2015	AT1 expression increased in the 2K1C compared with the Sham, ALSK and ALSK+L-arg groups, AT2 expression increased in the ALSK+L-arg group compared with the Sham and L-arg groups, and gp91phox decreased in the ALSK+L-arg group compared with the 2K1C and ALSK groups.	Arginine	126-131	angiotensin II receptor, type 2	Rattus norvegicus	89-92
25493385-10	2015	AT1 expression increased in the 2K1C compared with the Sham, ALSK and ALSK+L-arg groups, AT2 expression increased in the ALSK+L-arg group compared with the Sham and L-arg groups, and gp91phox decreased in the ALSK+L-arg group compared with the 2K1C and ALSK groups.	Arginine	126-131	angiotensin II receptor, type 2	Rattus norvegicus	89-92
25493385-10	2015	AT1 expression increased in the 2K1C compared with the Sham, ALSK and ALSK+L-arg groups, AT2 expression increased in the ALSK+L-arg group compared with the Sham and L-arg groups, and gp91phox decreased in the ALSK+L-arg group compared with the 2K1C and ALSK groups.	Arginine	126-131	angiotensin II receptor, type 2	Rattus norvegicus	89-92
25921643-9	2015	These ligands have been targeted at four key binding sites of the nNOS enzyme - the tetrahydrobiopterin, calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH) and arginine binding sites.	Arginine	173-181	nitric oxide synthase 1	Homo sapiens	66-70
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Arginine	21-29	secreted phosphoprotein 1	Rattus norvegicus	68-79
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Arginine	21-29	secreted phosphoprotein 1	Rattus norvegicus	81-84
25103078-8	2014	The Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene were associated with a significantly increased risk of UCB, with ORs of 1.8 [95% confidence interval (CI) = 1.2-2.6] and 2.1 (95% CI = 1.6-4.5), respectively.	Arginine	47-50	sulfotransferase family 1A member 1	Homo sapiens	71-78
25103078-8	2014	The Ala/Ala genotype of the GSTO1 gene and the Arg/Arg genotype of the SULT1A1 gene were associated with a significantly increased risk of UCB, with ORs of 1.8 [95% confidence interval (CI) = 1.2-2.6] and 2.1 (95% CI = 1.6-4.5), respectively.	Arginine	51-54	sulfotransferase family 1A member 1	Homo sapiens	71-78
25103078-9	2014	Significantly increased UCB risks were found in heavy smokers with the Ala/Ala genotype of the GSTO1 gene (OR = 4.2) and the Arg/Arg genotype of the SULT1A1 gene (OR = 6.8).	Arginine	125-128	sulfotransferase family 1A member 1	Homo sapiens	149-156
25103078-9	2014	Significantly increased UCB risks were found in heavy smokers with the Ala/Ala genotype of the GSTO1 gene (OR = 4.2) and the Arg/Arg genotype of the SULT1A1 gene (OR = 6.8).	Arginine	129-132	sulfotransferase family 1A member 1	Homo sapiens	149-156
25033248-6	2014	Profiling of the advanced glycation end products formed during the incubation of RNase A with methylglyoxal revealed predominant formation of the arginine modifications imidazolinone, CEA/dihydroxyimidazoline, and tetrahydropyrimidine at Arg10, Arg33, Arg39, and Arg85.	Arginine	146-154	ribonuclease A family member 1, pancreatic	Homo sapiens	81-88
24907905-2	2014	Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity.	Arginine	175-183	myelin basic protein	Homo sapiens	121-141
24907905-2	2014	Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity.	Arginine	175-183	myelin basic protein	Homo sapiens	143-146
26576438-2	2015	Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand beta1 and the beginning of strand beta2, respectively.	Arginine	51-60	arginase, liver	Mus musculus	0-5
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-34	arginase, liver	Mus musculus	64-74
26491198-2	2015	Increased metabolism of l-Arginine (l-Arg), through the enzymes arginase 1 and NO synthase 2 (NOS2), is well documented as a major MDSC suppressive mechanism.	Arginine	24-29	arginase, liver	Mus musculus	64-74
25528892-8	2015	In addition, three potential pathways and their related DEGs: spermidine/spermine N1-acetyltransferase 1, amiloride-binding protein 1 and adenosylmethionine decarboxylase 1 were associated with arginine and proline metabolism.	Arginine	194-202	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	62-104
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Arginine	141-151	arginase 1	Homo sapiens	0-10
25528892-8	2015	In addition, three potential pathways and their related DEGs: spermidine/spermine N1-acetyltransferase 1, amiloride-binding protein 1 and adenosylmethionine decarboxylase 1 were associated with arginine and proline metabolism.	Arginine	194-202	amine oxidase copper containing 1	Homo sapiens	106-133
26543159-5	2015	Histone peptide profiling revealed that human NRMT1 is highly selective to human CENP-A and fruit fly H2B, which share a common "Xaa-Pro-Lys/Arg" motif.	Arginine	141-144	centromere protein A	Homo sapiens	81-87
25550436-7	2015	Based on a structural alignment with DNA polymerase delta, we propose that arginines corresponding to R988 might have a similar function in other B-family polymerases.	Arginine	75-84	DNA polymerase delta 1, catalytic subunit	Homo sapiens	37-57
25110951-6	2014	We found that electrostatic interactions seem to play a key role in this complex formation which manifests in interactions between the C-terminal arginines of alpha2C-ARs (particularly R454 and R456) and negatively charged residues from filamin-2 region between residues 1979 and 2206.	Arginine	146-155	filamin C	Homo sapiens	237-246
25033204-1	2014	AIM: Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine.	Arginine	139-149	nitric oxide synthase 1, neuronal	Mus musculus	99-110
26538654-5	2015	Arginase 1 (Arg1) and nitric oxide synthases compete for l-arginine to produce either polyamines or nitric oxide, respectively.	Arginine	57-67	arginase, liver	Mus musculus	0-10
25033204-10	2014	Depletion of circulating L-arginine by arginase 1 infusion or inhibition of NOS activity with L-NAME resulted in an increased MAP (10 and 30 mmHg, respectively) in control and Ass-KOTie2 mice.	Arginine	25-35	arginase, liver	Mus musculus	39-49
26383032-2	2015	Transcripts encoding the kainate GRIK1 and AMPA GluA2 glutamate receptor subunits undergo editing that leads to a glycine/arginine (Q/R) exchange and reduced Ca(2+) permeability.	Arginine	122-130	glutamate receptor, ionotropic, kainate 1	Mus musculus	33-38
26383032-2	2015	Transcripts encoding the kainate GRIK1 and AMPA GluA2 glutamate receptor subunits undergo editing that leads to a glycine/arginine (Q/R) exchange and reduced Ca(2+) permeability.	Arginine	122-130	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	48-53
26383032-2	2015	Transcripts encoding the kainate GRIK1 and AMPA GluA2 glutamate receptor subunits undergo editing that leads to a glycine/arginine (Q/R) exchange and reduced Ca(2+) permeability.	Arginine	34-35	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	48-53
25003387-0	2014	Biophysical and biochemical analysis of hnRNP K: arginine methylation, reversible aggregation and combinatorial binding to nucleic acids.	Arginine	49-57	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	40-47
26538654-5	2015	Arginase 1 (Arg1) and nitric oxide synthases compete for l-arginine to produce either polyamines or nitric oxide, respectively.	Arginine	57-67	arginase, liver	Mus musculus	12-16
25003387-3	2014	Recombinant non-methylated and arginine-methylated hnRNP K (MethnRNP K) were used to characterize self-aggregation and nucleic acid binding.	Arginine	31-39	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	51-58
26517117-6	2015	Molecular docking results reveal that antroquinonol has an H-bond with the Arg 86 residue of FAK.	Arginine	75-78	protein tyrosine kinase 2	Homo sapiens	93-96
24802752-7	2014	Arg(28) is in close proximity to the CNTFR binding site.	Arginine	0-3	ciliary neurotrophic factor receptor	Homo sapiens	37-42
25533001-5	2014	EIAV Rev also contains a bipartite RNA binding domain comprising two short arginine-rich motifs (designated ARM-1 and ARM-2) spaced 79 residues apart in the amino acid sequence.	Arginine	75-83	Rev	Human immunodeficiency virus 1	5-8
26456755-4	2015	Here, we show in budding yeast that Lys-362 and Arg-367 residues of the largest subunit (Orc1), both outside the aforementioned domains, are crucial for specific binding of ORC to origin DNA.	Arginine	48-51	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	89-93
24802752-8	2014	Using molecular modeling, we hypothesized that Arg(28) might contribute to IL-6R/CNTFR plasticity of CNTF.	Arginine	47-50	ciliary neurotrophic factor receptor	Homo sapiens	81-86
25517031-2	2014	L-citrulline (CIT) can be converted to L-arginine to generate nitric oxide (NO).	Arginine	39-49	citron rho-interacting serine/threonine kinase	Rattus norvegicus	14-17
26456755-7	2015	A truncated Orc1 polypeptide containing these residues solely recognizes ARS sequence with low affinity and Arg-367 residue stimulates sequence specific binding mode of the polypeptide.	Arginine	108-111	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	12-16
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Arginine	41-49	peroxisomal biogenesis factor 5	Homo sapiens	61-66
24662292-8	2014	Several lines of evidence with lysine-to-arginine mutants of Pex5p demonstrate that Pex10p RING E3-mediated ubiquitination of Pex5p is required for its efficient export from peroxisomes to the cytosol and peroxisomal matrix protein import.	Arginine	41-49	peroxisomal biogenesis factor 5	Homo sapiens	126-131
26456755-8	2015	Lys-362 and Arg-367 residues of Orc1 are highly conserved among eukaryotic ORCs, but not in eubacterial and archaeal orthologs, suggesting a eukaryote-specific mechanism underlying recognition of replication origins by ORC.	Arginine	12-15	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	32-36
26436293-3	2015	Through analysis of the NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in NCOA4 is required for delivery of ferritin to the lysosome via autophagosomes.	Arginine	105-113	nuclear receptor coactivator 4	Danio rerio	24-29
24906965-5	2014	On genetic testing, the mutation at codon 424 (Leu Arg) in PSEN-1 gene was identified.	Arginine	51-54	presenilin 1	Homo sapiens	59-65
26311901-2	2015	The transmembrane region of TARM1 contained a conserved arginine residue, consistent with association with a signaling adaptor.	Arginine	56-64	T cell-interacting, activating receptor on myeloid cells 1	Mus musculus	28-33
24518840-5	2014	This alternative transcript is expressed in all controls and tested tissues, its upregulation is specific to the paternal c.2272C&gt;T mutation and depends on the abrogation of the binding motifs for SF2 and SRp55 serine/arginine-rich proteins with bypass of the mutation site located in the skipped exon 14 portion.	Arginine	221-229	serine and arginine rich splicing factor 6	Homo sapiens	208-213
25341953-0	2014	The arginine-facing amino acid residue of the rat aquaporin 1 constriction determines solute selectivity according to its size and lipophilicity.	Arginine	4-12	aquaporin 1	Rattus norvegicus	50-61
28983344-4	2015	In contrast, the FCGR2A GG genotype (Arg allele) was found to be positively associated with pCR (P = 0.012).	Arginine	37-40	Fc gamma receptor IIa	Homo sapiens	17-23
25190478-9	2014	The mutation in the Lox3 gene in H70 was a single-point mutation in exon 6 (A-G), which changed the amino acid from histidine to arginine.	Arginine	129-137	seed linoleate 9S-lipoxygenase-3	Glycine max	20-24
26078354-0	2015	Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3.	Arginine	18-26	eukaryotic translation initiation factor 4E	Homo sapiens	119-124
25339290-5	2014	First, the substitution to an arginine of K327 mutation was associated with a reduction in CXCR2 poly-ubiquitination.	Arginine	30-38	C-X-C motif chemokine receptor 2	Homo sapiens	91-96
26078354-11	2015	Collectively, our findings provide new evidence that PRMT5 plays an important role in CRC pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E and FGFR3.	Arginine	137-145	eukaryotic translation initiation factor 4E	Homo sapiens	179-184
26221041-2	2015	This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immune signaling, is regulated by reversible arginine methylation in a range of primary and cultured cells.	Arginine	159-167	LOC222344	Homo sapiens	30-62
25193658-4	2014	Mutating several lysines of the gamma2IL into arginines makes the gamma2 subunit resistant to RNF34-induced degradation.	Arginine	46-55	crystallin, gamma E	Rattus norvegicus	32-38
26221041-2	2015	This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immune signaling, is regulated by reversible arginine methylation in a range of primary and cultured cells.	Arginine	159-167	LOC222344	Homo sapiens	64-69
26221041-8	2015	Reversible arginine methylation of TRAF6 by the opposing effects of PRMT1 and JMJD6 is, therefore, a novel mechanism for regulation of innate immune pathways.	Arginine	11-19	LOC222344	Homo sapiens	35-40
25220139-2	2014	In this work, an ultrasensitive solid-state electrochemiluminescence (ECL) immunosensor is designed to determine APE-1 based on the new Ru(bpy)3(2+)/bi-arginine system.	Arginine	151-160	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	113-118
26002808-10	2015	Ort1p is involved in the biosynthesis of arginine and polyamines in yeast.	Arginine	41-49	Ort1p	Saccharomyces cerevisiae S288C	0-5
24913445-6	2014	A strong intermolecular interaction was predicted between the Arg(25) residue of 26RFa and the Gln(125) residue located in the third transmembrane helix of GPR103.	Arginine	62-65	pyroglutamylated RFamide peptide	Homo sapiens	81-86
24913445-6	2014	A strong intermolecular interaction was predicted between the Arg(25) residue of 26RFa and the Gln(125) residue located in the third transmembrane helix of GPR103.	Arginine	62-65	pyroglutamylated RFamide peptide receptor	Homo sapiens	156-162
26123990-1	2015	Hyperargininemia is caused by deficiency of arginase 1, which catalyzes the hydrolysis of L-arginine to urea as the final enzyme in the urea cycle.	Arginine	90-100	arginase 1	Homo sapiens	44-54
25112876-7	2014	Further, when an amino-terminal fragment (Met(1)-Arg(33)) of the N170K/K297G double mutant of hRPE65 was replaced with the corresponding cRPE65 fragment, the isomerohydrolase activity was further increased to a level similar to that of cRPE65.	Arginine	49-52	retinoid isomerohydrolase RPE65	Homo sapiens	94-100
26071957-5	2015	The NMDA-receptor (NMDA-R) antagonists ketamine and MK-801 (10nM) counteracted the NMDA/glycine-induced reduction in neurite outgrowth and the neuronal NO synthase (nNOS) inhibitor 1-[2-(trifluoromethyl)phenyl] imidazole (TRIM) (100nM) counteracted both the NMDA/glycine and l-arginine-induced decreases in neurite outgrowth.	Arginine	24-25	nitric oxide synthase 1	Homo sapiens	165-169
25201986-5	2014	Arginase-1 (Arg1) also metabolizes l-arginine but does not require oxygen as a substrate and has been shown to regulate NOS2 via substrate competition.	Arginine	35-45	arginase, liver	Mus musculus	12-16
24806446-0	2014	TIPE2 negatively regulates inflammation by switching arginine metabolism from nitric oxide synthase to arginase.	Arginine	53-61	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	0-5
24726729-5	2014	Nevertheless, arginine methylation of CNBP appeared to interfere with its RNA binding activity.	Arginine	14-22	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	38-42
24726729-6	2014	Our findings show that arginine methylation of CNBP in the RG motif did not change the subcellular localization, but regulated its RNA binding activity.	Arginine	23-31	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	47-51
24568585-5	2014	CLK1 plays an important role in the regulation of RNA splicing through phosphorylation of members of the serine and arginine-rich (SR) family of splicing factors.	Arginine	116-124	CDC like kinase 1	Homo sapiens	0-4
24632551-8	2014	CONCLUSIONS: Our results suggest that in the rat islets, TRPM5 is involved in mediating insulin secretion by glucose and l-arginine and in potentiating the glucose-induced insulin secretion by glucagon-like peptide 1.	Arginine	121-131	transient receptor potential cation channel, subfamily M, member 5	Rattus norvegicus	57-62
25191616-8	2014	A parenteral bolus of glucose or arginine increased insulin and ghrelin concentrations in cats.	Arginine	33-41	insulin	Felis catus	52-59
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	peroxisome proliferator-activated receptor gamma	Gallus gallus	108-118
24648395-2	2014	However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals.	Arginine	23-31	agmatinase	Homo sapiens	122-132
24648395-2	2014	However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals.	Arginine	23-31	agmatinase	Homo sapiens	134-139
24648395-5	2014	Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses.	Arginine	209-217	agmatinase	Homo sapiens	88-93
24648395-5	2014	Furthermore, we found that increases in ADC/AGMAT mRNA levels and in the translation of AGMAT mRNA among conceptuses in MAO-ODC1 knockdown compensated for the loss of ODC1, supporting polyamine synthesis from arginine and accounting for the normal and abnormal phenotypes of conceptuses.	Arginine	209-217	ornithine decarboxylase 1	Homo sapiens	124-128
24648395-7	2014	The presence of an alternative ADC/AGMAT pathway for converting arginine into putrescine is functionally important for supporting survival and development of mammalian conceptuses.	Arginine	64-72	agmatinase	Homo sapiens	35-40
24743736-5	2014	Mutation in the mesotrypsin-susceptible Arg-rich region between FLG-N and the first filaggrin domain abolished these changes.	Arginine	40-43	serine protease 3	Homo sapiens	16-27
24591237-2	2014	In this study, we show that the HIV Tat aptamer RNA is capable of recognizing two consecutive arginine residues within the Tat peptide, thus demonstrating how RNA might be able to position two amino acids for sequence-specific coupling.	Arginine	94-102	tyrosine aminotransferase	Homo sapiens	36-39
24591237-2	2014	In this study, we show that the HIV Tat aptamer RNA is capable of recognizing two consecutive arginine residues within the Tat peptide, thus demonstrating how RNA might be able to position two amino acids for sequence-specific coupling.	Arginine	94-102	tyrosine aminotransferase	Homo sapiens	123-126
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Arginine	44-52	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
24815390-8	2014	A substantial number of membrane proteins possessed the triplet Tyr-Phe-Arg and some of them might be in vivo substrates for Gr3.	Arginine	72-75	granzyme K	Homo sapiens	125-128
25302076-0	2014	Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development.	Arginine	20-28	H2A.X variant histone S homeolog	Xenopus laevis	54-57
26271664-4	2015	NAG is the substrate for the second step of arginine biosynthesis catalysed by NAG kinase (ArgB).	Arginine	44-52	acetylglutamate kinase	Sinorhizobium meliloti 1021	91-95
24096484-0	2014	c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer.	Arginine	10-13	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	69-76
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	114-121
24361123-7	2014	RESULTS: After injection of l-arginine or cerulein, Pdx1-Cre; HMGB1(flox/flox) mice developed acute pancreatitis more rapidly than controls, with increased mortality.	Arginine	28-38	pancreatic and duodenal homeobox 1	Mus musculus	52-56
24361123-7	2014	RESULTS: After injection of l-arginine or cerulein, Pdx1-Cre; HMGB1(flox/flox) mice developed acute pancreatitis more rapidly than controls, with increased mortality.	Arginine	28-38	high mobility group box 1	Mus musculus	62-67
24361123-9	2014	Pancreatic tissues and acinar cells collected from the Pdx1-Cre; HMGB1(flox/flox) mice after l-arginine or cerulein injection demonstrated nuclear catastrophe with greater nucleosome release when compared with controls, along with increased phosphorylation/activation of RELA nuclear factor kappaB, degradation of inhibitor of kappaB, and phosphorylation of mitogen-activated protein kinase.	Arginine	93-103	pancreatic and duodenal homeobox 1	Mus musculus	55-59
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	200-207
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	183-186	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	114-121
24361123-10	2014	Inhibitors of reactive oxygen species (N-acetyl-l-cysteine) blocked l-arginine-induced DNA damage, necrosis, apoptosis, release of nucleosomes, and activation of nuclear factor kappaB in pancreatic tissues and acinar cells from Pdx1-Cre; HMGB1(flox/flox) and control mice.	Arginine	68-78	pancreatic and duodenal homeobox 1	Mus musculus	228-232
26271664-5	2015	Inactivation of argB in strain 1021 resulted in arginine auxotrophy.	Arginine	48-56	acetylglutamate kinase	Sinorhizobium meliloti 1021	16-20
24361123-10	2014	Inhibitors of reactive oxygen species (N-acetyl-l-cysteine) blocked l-arginine-induced DNA damage, necrosis, apoptosis, release of nucleosomes, and activation of nuclear factor kappaB in pancreatic tissues and acinar cells from Pdx1-Cre; HMGB1(flox/flox) and control mice.	Arginine	68-78	high mobility group box 1	Mus musculus	238-243
26271664-6	2015	The activity of purified ArgB was significantly inhibited by arginine but not by ornithine.	Arginine	61-69	acetylglutamate kinase	Sinorhizobium meliloti 1021	25-29
25703582-5	2015	NMDA receptor activation may also dampen mTORC1 activity by at least two possible mechanisms: regulating intraneuronal accumulation of arginine and the phosphorylation status of a specific extracellular signal regulating kinase (i.e., ERK1/2), both of which are "drivers" of mTORC1 activity.	Arginine	135-143	CREB regulated transcription coactivator 1	Mus musculus	41-47
24616519-5	2014	We have identified a short, arginine-rich linear motif in NPM1 binding partners that mediates Npm-N oligomerization.	Arginine	28-36	nucleophosmin 1	Homo sapiens	58-62
24616519-5	2014	We have identified a short, arginine-rich linear motif in NPM1 binding partners that mediates Npm-N oligomerization.	Arginine	28-36	nucleophosmin 1	Homo sapiens	94-97
25156428-2	2014	However, the recently discovered neutrophil serine protease 4 (NSP4, also known as PRSS57) presents a paradox: NSP4 exhibits a trypsin-like specificity for cleaving substrates after arginine residues, but it bears elastase-like specificity determining residues in the active site.	Arginine	182-190	serine protease 57	Homo sapiens	63-67
25156428-2	2014	However, the recently discovered neutrophil serine protease 4 (NSP4, also known as PRSS57) presents a paradox: NSP4 exhibits a trypsin-like specificity for cleaving substrates after arginine residues, but it bears elastase-like specificity determining residues in the active site.	Arginine	182-190	serine protease 57	Homo sapiens	83-89
25156428-2	2014	However, the recently discovered neutrophil serine protease 4 (NSP4, also known as PRSS57) presents a paradox: NSP4 exhibits a trypsin-like specificity for cleaving substrates after arginine residues, but it bears elastase-like specificity determining residues in the active site.	Arginine	182-190	serine protease 57	Homo sapiens	111-115
25156428-4	2014	This uncommon arrangement, conserved in all NSP4 orthologs, enables NSP4 to process substrates after both arginine as well as post-translationally modified arginine residues, such as methylarginine and citrulline.	Arginine	106-114	serine protease 57	Homo sapiens	44-48
25156428-4	2014	This uncommon arrangement, conserved in all NSP4 orthologs, enables NSP4 to process substrates after both arginine as well as post-translationally modified arginine residues, such as methylarginine and citrulline.	Arginine	106-114	serine protease 57	Homo sapiens	68-72
25156428-4	2014	This uncommon arrangement, conserved in all NSP4 orthologs, enables NSP4 to process substrates after both arginine as well as post-translationally modified arginine residues, such as methylarginine and citrulline.	Arginine	156-164	serine protease 57	Homo sapiens	44-48
25156428-4	2014	This uncommon arrangement, conserved in all NSP4 orthologs, enables NSP4 to process substrates after both arginine as well as post-translationally modified arginine residues, such as methylarginine and citrulline.	Arginine	156-164	serine protease 57	Homo sapiens	68-72
25960396-7	2015	We also find that the N-terminal ubiquitination sites are conserved in all the three Ube2Es and replacing them with arginine renders all three full-length Ube2Es equally active as their core UBC domains.	Arginine	116-124	ubiquitin like modifier activating enzyme 7	Homo sapiens	155-159
25104022-0	2014	Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	24-30
25104022-5	2014	In the present study, we demonstrated that the methylation of two essential arginines, Arg296 and Arg299, on hnRNPK inhibited a nearby Ser302 phosphorylation that was mediated through the pro-apoptotic kinase PKCdelta.	Arginine	76-85	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	109-115
25104022-5	2014	In the present study, we demonstrated that the methylation of two essential arginines, Arg296 and Arg299, on hnRNPK inhibited a nearby Ser302 phosphorylation that was mediated through the pro-apoptotic kinase PKCdelta.	Arginine	76-85	protein kinase C delta	Homo sapiens	209-217
25104022-8	2014	Here, we provide the first evidence that the arginine methylation of hnRNPK negatively regulates cell apoptosis through PKCdelta-mediated signaling during DNA damage, which is essential for the anti-apoptotic role of hnRNPK in apoptosis and the evasion of apoptosis in cancer cells.	Arginine	45-53	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	69-75
24748754-10	2014	Kaempferol-3-O-b-D-glucopyranoside, a Secondary metabolite of S.interrupta form 6 hydrogen bond interactions with Arg 202, Gln 207, Gly 227, Gly 229, Thr 231 and Ala 232 human DEAD box RNA helicase, DDX3 protein and is equivalent to crystal structure of adenosine mono phosphate to DDX3.	Arginine	114-117	DEAD-box helicase 3 X-linked	Homo sapiens	199-203
24748754-10	2014	Kaempferol-3-O-b-D-glucopyranoside, a Secondary metabolite of S.interrupta form 6 hydrogen bond interactions with Arg 202, Gln 207, Gly 227, Gly 229, Thr 231 and Ala 232 human DEAD box RNA helicase, DDX3 protein and is equivalent to crystal structure of adenosine mono phosphate to DDX3.	Arginine	114-117	DEAD-box helicase 3 X-linked	Homo sapiens	282-286
25104022-8	2014	Here, we provide the first evidence that the arginine methylation of hnRNPK negatively regulates cell apoptosis through PKCdelta-mediated signaling during DNA damage, which is essential for the anti-apoptotic role of hnRNPK in apoptosis and the evasion of apoptosis in cancer cells.	Arginine	45-53	protein kinase C delta	Homo sapiens	120-128
25104022-8	2014	Here, we provide the first evidence that the arginine methylation of hnRNPK negatively regulates cell apoptosis through PKCdelta-mediated signaling during DNA damage, which is essential for the anti-apoptotic role of hnRNPK in apoptosis and the evasion of apoptosis in cancer cells.	Arginine	45-53	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	217-223
26439994-15	2015	Foal insulin AUC and peak insulin concentrations were increased when mares were fed concentrate and, in a later trial, foal peak glucose values were reduced with arginine supplementation of the mare.	Arginine	162-170	INS	Equus caballus	5-12
25272937-1	2014	Lipoamino acid nanocarriers based on the interactions between L-arginine and oleic acid were formulated with the aid of Tween 80 and explored as a novel carrier for the oral administration of insulin.	Arginine	62-72	insulin	Oryctolagus cuniculus	192-199
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Arginine	129-137	lysine permease	Saccharomyces cerevisiae S288C	96-100
24448798-7	2014	We show that the single substitution T456S results in a Can1 variant transporting lysine in addition to arginine and that the combined substitutions T456S and S176N convert Can1 to a Lyp1-like permease.	Arginine	104-112	lysine permease	Saccharomyces cerevisiae S288C	183-187
25728785-1	2015	According to the Arg/N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thaliana E3 ligase, PROTEOLYSIS6 (PRT6).	Arginine	17-20	proteolysis 6	Arabidopsis thaliana	139-151
24246952-5	2014	It was demonstrated that anti-KL-6 monoclonal antibody shows an extremely specific and strong binding affinity toward MUC1 fragments carrying sialyl T antigen (Neu5Acalpha2,3Galbeta1,3GalNAcalpha1 ) at Pro-Asp-Thr-Arg motif when compared with other seven anti-MUC1 monoclonal antibodies such as VU-3D1, VU-12E1, VU-11E2, Ma552, VU-3C6, SM3, and DF3.	Arginine	214-217	mucin 1, cell surface associated	Homo sapiens	118-122
24472039-2	2014	Nonetheless, many nNOS inhibitors mimic l-arginine and are poorly bioavailable.	Arginine	40-50	nitric oxide synthase 1	Homo sapiens	18-22
25105596-5	2014	MALT1 cleavage occurred after Arginine 149, between the N-terminal death domain and the first immunoglobulin-like region, and did not affect its proteolytic activity.	Arginine	30-38	MALT1 paracaspase	Homo sapiens	0-5
25728785-1	2015	According to the Arg/N-end rule pathway, proteins with basic N-termini are targeted for degradation by the Arabidopsis thaliana E3 ligase, PROTEOLYSIS6 (PRT6).	Arginine	17-20	proteolysis 6	Arabidopsis thaliana	153-157
24894645-2	2014	The arginine grafted bio-reducible poly (cystamine bisacrylamide-diaminohexane, CBA-DAH) polymer (ABP) conjugated poly (amido amine) (PAMAM), PAM-ABP (PA) was designed previously as an efficient gene delivery carrier.	Arginine	4-12	amine oxidase copper containing 1	Homo sapiens	98-101
25947374-0	2015	Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2"-deoxyguanosine.	Arginine	18-21	DNA polymerase eta	Homo sapiens	45-63
24299430-3	2014	We report an efficient strategy that overcomes challenges in structural analysis of such a weak transient interaction between the Tudor domain of the Survival of Motor Neuron (SMN) protein and symmetrically dimethylated arginine (sDMA).	Arginine	220-228	survival of motor neuron 1, telomeric	Homo sapiens	150-174
24299430-3	2014	We report an efficient strategy that overcomes challenges in structural analysis of such a weak transient interaction between the Tudor domain of the Survival of Motor Neuron (SMN) protein and symmetrically dimethylated arginine (sDMA).	Arginine	220-228	survival of motor neuron 1, telomeric	Homo sapiens	176-179
25947374-2	2015	Crystal structures show that Arg-61 and Gln-38 are located near the active site and may play important roles in the fidelity and efficiency of hpol eta.	Arginine	29-32	endothelin receptor type A	Homo sapiens	148-151
25034973-13	2014	CONCLUSIONS: Taking together, we demonstrate here for the first time that Arg-II causes eNOS-uncoupling through activation of p38 mapk in HFD-induced obesity.	Arginine	74-77	mitogen-activated protein kinase 14	Mus musculus	126-129
25947374-5	2015	Crystal structures of hpol eta mutant ternary complexes reveal that polarized water molecules can mimic and partially compensate for the missing side chains of Arg-61 and Gln-38 in the Q38A/R61A mutant.	Arginine	160-163	endothelin receptor type A	Homo sapiens	27-30
26085034-6	2015	Individuals over 50 years of age and those with high dietary arginine consumption had increased basal expression of CyclinD1, AXIN2, cMYC and CD133 (p value range 0   04 to &lt;0   001) that, following grape ingestion, were reduced to levels seen in younger participants.The reduction in Wnt signaling and mucosal proliferation seen following short-term ingestion of 1/3-1 lb (0.15-0.45 kg) of grapes per day may reduce the risk of mutational events that can facilitate colon carcinogenesis.	Arginine	61-69	cyclin D1	Homo sapiens	116-124
24912149-6	2014	We identify four Hv1 residues involved in the binding: aspartate 112, phenylalanine 150, serine 181, and arginine 211.	Arginine	105-113	hydrogen voltage gated channel 1	Homo sapiens	17-20
24911253-1	2014	Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle.	Arginine	57-65	arginase 1	Homo sapiens	0-10
24686079-5	2014	Stimulation with Apelin-13 and des -Arg(9)-BK enhanced the phosphorylation of eNOS in HUVECs, which could be dampened by the knockdown of APJ or B1R, indicating the co-existence of APJ and B1R is critical for eNOS phosphorylation in HUVECs.	Arginine	36-39	apelin receptor	Homo sapiens	138-141
24686079-5	2014	Stimulation with Apelin-13 and des -Arg(9)-BK enhanced the phosphorylation of eNOS in HUVECs, which could be dampened by the knockdown of APJ or B1R, indicating the co-existence of APJ and B1R is critical for eNOS phosphorylation in HUVECs.	Arginine	36-39	apelin receptor	Homo sapiens	181-184
24807184-8	2014	The domestic cat SLAM had threonine at 76, whereas the lion SLAM had arginine, a positively charged residue like that of the dog SLAM.	Arginine	69-77	signaling lymphocytic activation molecule family member 1	Canis lupus familiaris	60-64
24763827-7	2014	No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR = 1.218, 95 % CI = 1.067-1.392, P = 0.0044) under the recessive model.	Arginine	169-172	sulfotransferase family 1A member 1	Homo sapiens	161-168
24763827-10	2014	The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.	Arginine	60-63	sulfotransferase family 1A member 1	Homo sapiens	52-59
24763827-10	2014	The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.	Arginine	207-210	sulfotransferase family 1A member 1	Homo sapiens	52-59
24764298-0	2014	Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability.	Arginine	9-17	programmed cell death 4	Homo sapiens	33-56
24814345-4	2014	In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively.	Arginine	36-44	ribosomal oxygenase 1	Homo sapiens	183-187
24759104-7	2014	Crystal structures of ternary hpol eta-DNA complexes and incoming dCTP, dATP, or dGTP opposite 8-oxoG reveal that an arginine from the finger domain assumes a key role in avoiding formation of the nascent 8-oxoG:A pair.	Arginine	117-125	endothelin receptor type A	Homo sapiens	35-38
24753255-6	2014	Furthermore, NF-kappaB p65, a critical driver of TNF-alpha-mediated CXCL10 induction, was determined to be methylated at arginine residues.	Arginine	121-129	RELA proto-oncogene, NF-kB subunit	Homo sapiens	23-26
24753255-8	2014	Mass spectrometric analysis in EC identified five dimethylated arginine residues in p65, four of which are uncharacterized in the literature.	Arginine	63-71	RELA proto-oncogene, NF-kB subunit	Homo sapiens	84-87
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Arginine	14-17	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Arginine	69-72	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Arginine	69-72	RELA proto-oncogene, NF-kB subunit	Homo sapiens	42-45
24735539-7	2014	An in silico docking analysis showed that one of the salt bridges between noggin and heparin disappeared following the replacement of the arginine with a non-charged cysteine.	Arginine	138-146	noggin	Homo sapiens	74-80
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Arginine	28-31	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	60-64
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Arginine	28-31	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	160-164
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Arginine	49-52	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	60-64
24652287-7	2014	These studies revealed that Arg-80, Lys-350, and Arg-190 of 2OST interact with the N-sulfo groups near the modification site, consistent with the dependence of 2OST on N-sulfation.	Arginine	49-52	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	160-164
25594030-4	2014	The ZFX mutations we identified were strikingly specific, focused in each tumor on one encoded residue in a hotspot of two consecutive highly conserved arginine residues (R786/787; arginine to glutamine, threonine or leucine) in a zinc finger domain near the C-terminus of the protein.	Arginine	152-160	zinc finger protein X-linked	Homo sapiens	4-7
25594030-4	2014	The ZFX mutations we identified were strikingly specific, focused in each tumor on one encoded residue in a hotspot of two consecutive highly conserved arginine residues (R786/787; arginine to glutamine, threonine or leucine) in a zinc finger domain near the C-terminus of the protein.	Arginine	181-189	zinc finger protein X-linked	Homo sapiens	4-7
24615237-0	2014	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.	Arginine	152-160	relaxin family peptide receptor 3	Homo sapiens	92-97
24615237-3	2014	We speculated that these positively charged arginines may interact with certain negatively charged residues of RXFP3.	Arginine	44-53	relaxin family peptide receptor 3	Homo sapiens	111-116
24615237-4	2014	To test this hypothesis, we first replaced the negatively charged residues in the extracellular domain of RXFP3 with arginine, respectively.	Arginine	117-125	relaxin family peptide receptor 3	Homo sapiens	106-111
24615237-8	2014	To identify the ligand residues interacting with the negatively charged EXXXD motif of RXFP3, we replaced the three conserved arginines of relaxin-3 with negatively charged glutamate or aspartate, respectively.	Arginine	126-135	relaxin family peptide receptor 3	Homo sapiens	87-92
24502766-6	2014	This effect was associated with an increase in fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) mRNA levels in SAT, which suggests that arginine might be involved in the differential regulation of some key lipogenic genes in pig muscle and SAT.	Arginine	148-156	fatty acid synthase	Sus scrofa	47-66
24502766-6	2014	This effect was associated with an increase in fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD) mRNA levels in SAT, which suggests that arginine might be involved in the differential regulation of some key lipogenic genes in pig muscle and SAT.	Arginine	148-156	fatty acid synthase	Sus scrofa	68-72
24788778-0	2014	Effects of Arginine concentration on the in vitro expression of Casein and mTOR pathway related genes in mammary epithelial cells from dairy cattle.	Arginine	11-19	mechanistic target of rapamycin kinase	Bos taurus	75-79
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	mechanistic target of rapamycin kinase	Bos taurus	73-77
24788778-10	2014	Taken together, Arg appears to play an important role in the transcriptional regulation of casein genes and mTOR-related genes in bovine mammary epithelial cells.	Arginine	16-19	mechanistic target of rapamycin kinase	Bos taurus	108-112
24616097-0	2014	The Arg-62 residues of the TREX1 exonuclease act across the dimer interface contributing to catalysis in the opposing protomers.	Arginine	4-7	three prime repair exonuclease 1	Homo sapiens	27-32
24616097-5	2014	Studies here show that the TREX1 Arg-62 residues extend across the dimer interface into the active site of the opposing protomer to coordinate substrate DNA and to affect catalysis in the opposing protomer.	Arginine	33-36	three prime repair exonuclease 1	Homo sapiens	27-32
32261374-4	2014	We designed hydroxyapatite/gold/arginine (HAp/Au/arginine) nanocomposite that contains: (i) hydrophobic gold (Au) nanoparticles, (b) positively charged, hydrophilic arginine molecules that functionalize the surface of the Au and (c) hydroxyapatite (HAp) bioactive carrier of the functionalized Au nanoparticles.	Arginine	32-40	reticulon 3	Homo sapiens	42-45
24651064-2	2014	As a result of UV-B light perception, the UVR8 homodimer shaped by its arginine residues undergoes a conformational switch of monomerization.	Arginine	71-79	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	42-46
24651064-6	2014	Here, we take advantage of transgenic UVR8 variants to demonstrate that two light-absorbing tryptophans, W233 and W285, and two dimer-stabilizing arginines, R286 and R338, play pivotal roles in UV-B-induced photomorphogenesis.	Arginine	146-155	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	38-42
24240276-7	2014	The uracil base at the extreme 3" end is sandwiched by His 36 and Arg 69 from Lsm3, through pi-pi and cation-pi interactions, respectively.	Arginine	66-69	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	78-82
24357096-9	2014	RESULTS: The results suggests a protective effect of the genotypes Arg/Lys of AhR rs2066853 (odds ratio [OR] 0.55, p = 0.03), Ile/Val of CYP1A1 rs1048943 (OR 0.49, p = 0.009), Tyr/His of EPHX1 rs1051740 (OR 0.53, p = 0.03), and A/A of CCND1 rs603965 (OR 0.44, p = 0.02).	Arginine	67-70	aryl hydrocarbon receptor	Homo sapiens	78-81
24465919-1	2014	RATIONALE AND OBJECTIVE: Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity.	Arginine	100-108	arginase, liver	Mus musculus	25-35
24465919-2	2014	In this study Arg1(fl/fl)/Tie2-Cre(tg/-) mice were developed to investigate the effect of arginase-1 related arginine depletion on NOS2- and NOS3-dependent NO production and jejunal microcirculation under resting and endotoxemic conditions, in mice lacking arginase-1 in endothelial and hematopoietic cells.	Arginine	109-117	arginase, liver	Mus musculus	90-100
25051764-1	2014	While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.	Arginine	61-64	caspase 3	Rattus norvegicus	73-82
23470573-14	2014	CONCLUSIONS: Arginine availability is decreased after PI coinciding with an induction of MDSC expressing arginase 1.	Arginine	13-21	arginase, liver	Mus musculus	105-115
24761888-6	2014	Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively.	Arginine	112-115	aryl hydrocarbon receptor	Homo sapiens	120-123
25036121-5	2014	Consistent with these, arginine uptake into vacuolar membrane vesicles was decreased by Avt4p-, but not by Avt3p-overproduction, whereas various neutral amino acids were excreted from vacuolar membrane vesicles in a manner dependent on either Avt4p or Avt3p.	Arginine	23-31	Avt3p	Saccharomyces cerevisiae S288C	252-257
24180388-6	2014	nNOS was first found to produce superoxide under L-arginine depletion condition.	Arginine	49-59	nitric oxide synthase 1	Homo sapiens	0-4
24227843-4	2014	Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases.	Arginine	19-27	angiotensin converting enzyme 2	Homo sapiens	55-59
24113750-7	2014	Computational modeling and ligand docking predicted the contributions of different arginine residues, other than at 3.36, in human GPR35 for these two ligands and were consistent with selective loss of potency of either bufrolin or lodoxamide at distinct arginine mutants.	Arginine	83-91	G protein-coupled receptor 35	Homo sapiens	131-136
24113750-7	2014	Computational modeling and ligand docking predicted the contributions of different arginine residues, other than at 3.36, in human GPR35 for these two ligands and were consistent with selective loss of potency of either bufrolin or lodoxamide at distinct arginine mutants.	Arginine	255-263	G protein-coupled receptor 35	Homo sapiens	131-136
24349250-7	2013	We demonstrate that this difference in calmodulin binding was due to the unique cysteine residue in the KCNQ2 subunit at aa 527 in Helix B, which corresponds to an arginine residue in other KCNQ subunits including KCNQ3.	Arginine	164-172	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	214-219
24163367-6	2013	We also show that the cytoplasmic amino-terminal region of THIK2 (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal.	Arginine	88-96	potassium two pore domain channel subfamily K member 12	Homo sapiens	59-64
24163367-6	2013	We also show that the cytoplasmic amino-terminal region of THIK2 (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal.	Arginine	88-96	potassium two pore domain channel subfamily K member 12	Homo sapiens	69-74
24163367-8	2013	Cell surface delivery of a Nt-THIK2-CD161 chimera is increased by mutating the arginines of the retention motif but also by converting the serine embedded in this motif to aspartate, suggesting a phosphorylation-dependent regulation of THIK2 trafficking.	Arginine	79-88	potassium two pore domain channel subfamily K member 12	Homo sapiens	30-35
24183574-0	2013	Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.	Arginine	100-108	pygopus	Drosophila melanogaster	35-39
24328739-2	2013	Arginine 132 (R132) of IDH1 and arginine 172 (R172) of IDH2 are functionally important residues.	Arginine	0-8	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	23-27
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Arginine	64-67	insulin receptor	Homo sapiens	125-127
24250787-2	2013	There are two common naturally occurring polymorphisms within the human beta1-adrenoceptor sequence: Ser or Gly at position 49 in the N-terminus and Gly or Arg at position 389 in the C-terminus and some clinical studies have suggested that expression of certain variants may be associated with disease and affect response to treatment with beta-blockers.	Arginine	156-159	adrenoceptor beta 1	Homo sapiens	72-90
23959939-0	2013	Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice.	Arginine	5-15	glucagon	Mus musculus	27-32
23959939-4	2013	Here we tested the hypothesis that oral L-arginine acts as a GLP-1 secretagogue in vivo, to augment postprandial insulin secretion and improve glucose tolerance.	Arginine	40-50	glucagon	Mus musculus	61-66
23959939-6	2013	In both lean and obese mice oral L-arginine increased plasma GLP-1 and insulin and substantially improved glucose clearance.	Arginine	33-43	glucagon	Mus musculus	61-66
23959939-9	2013	Taken together these findings identify L-arginine as a GLP-1 secretagogue in vivo and demonstrate that improvement of glucose tolerance by oral L-arginine depends on GLP-1R-signaling.	Arginine	39-49	glucagon	Mus musculus	55-60
23959939-10	2013	These findings raise the intriguing possibility that L-arginine-based nutritional and/or pharmaceutical therapies may benefit glucose tolerance by improving the postprandial GLP-1 response in obese individuals.	Arginine	53-63	glucagon	Mus musculus	174-179
24067598-2	2013	The mechanism behind the reduction of NO is related to deficiency of the NO synthase (NOS) substrate L-arginine and cofactor tetrahydrobiopterin (BH4) resulting in NOS uncoupling.	Arginine	101-111	nitric oxide synthase 3	Sus scrofa	73-84
24354792-3	2014	A key N-terminal arginine in each of PARs 1 to 4 has been singled out as a target for cleavage by thrombin (PARs 1, 3 and 4), trypsin (PARs 2 and 4) or other proteases to unmask the TL that activates signalling via Gq , Gi or G12 /13 .	Arginine	17-25	F2R like trypsin receptor 1	Homo sapiens	135-147
24037816-6	2014	Tyrosine-10 phosphorylation of Na,K-ATPase alpha1 subunit was detected in SNP and L-arginine-treated cells and the response prevented by PP2.	Arginine	82-92	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	137-140
26085034-6	2015	Individuals over 50 years of age and those with high dietary arginine consumption had increased basal expression of CyclinD1, AXIN2, cMYC and CD133 (p value range 0   04 to &lt;0   001) that, following grape ingestion, were reduced to levels seen in younger participants.The reduction in Wnt signaling and mucosal proliferation seen following short-term ingestion of 1/3-1 lb (0.15-0.45 kg) of grapes per day may reduce the risk of mutational events that can facilitate colon carcinogenesis.	Arginine	61-69	prominin 1	Homo sapiens	142-147
23924325-10	2013	This is rationalized by competition between phosphorylated T287 and T288 for a binding site composed of arginines, based on a structure of Aurora-A in which phospho-T287 occupies this site.	Arginine	104-113	aurora kinase A	Homo sapiens	139-147
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	CDR3	Homo sapiens	186-190
24570487-0	2014	Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism.	Arginine	0-8	CREB regulated transcription coactivator 2	Mus musculus	24-29
24570487-4	2014	In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes.	Arginine	62-70	CREB regulated transcription coactivator 2	Mus musculus	83-88
24570487-4	2014	In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes.	Arginine	62-70	CREB regulated transcription coactivator 2	Mus musculus	124-129
24019529-6	2013	Our studies revealed that mutation of Glu(183), Ser(244), and Arg(288) impaired homodimerization of the MyD88-TIR domain, recruitment of IRAKs, and activation of NF-kappaB.	Arginine	62-65	MYD88 innate immune signal transduction adaptor	Homo sapiens	104-109
26068232-2	2015	In microorganisms and plants, the enzyme functions in the arginine biosynthetic pathway, while in mammals, its major role is to produce the essential co-factor of carbamoyl phosphate synthetase 1 (CPS1) in the urea cycle.	Arginine	58-66	carbamoyl-phosphate synthase 1	Homo sapiens	163-195
25878251-1	2015	Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36) Ser(37) reveal a tethered ligand that binds to the cleaved receptor.	Arginine	64-67	F2R like trypsin receptor 1	Homo sapiens	22-51
24076217-0	2013	Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.	Arginine	0-8	E2F transcription factor 1 L homeolog	Xenopus laevis	81-86
24338824-9	2014	The decrease in both cGMP generation, a measure of eNOS activity, and aortic eNOS and phosphorylated eNOS abundance observed in CRF rats was completely abolished by l-arginine, while arginine transport and CAT-1 protein were unchanged in all experimental groups.	Arginine	167-175	solute carrier family 7 member 1	Rattus norvegicus	206-211
25795782-4	2015	This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4/VAV1/RAC1 NADPH oxidase complex.	Arginine	37-40	neutrophil cytosolic factor 2	Homo sapiens	94-98
24028840-1	2014	Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins.	Arginine	119-127	carboxypeptidase N, polypeptide 1	Mus musculus	0-18
24028840-1	2014	Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins.	Arginine	119-127	carboxypeptidase N, polypeptide 1	Mus musculus	20-23
24349641-0	2013	Effects of the Arg-Pro and Gly-Gly-Nle Moieties on Melanocortin-1 Receptor Binding Affinities of alpha-MSH Peptides.	Arginine	15-18	pro-opiomelanocortin-alpha	Mus musculus	97-106
23428392-11	2013	In addition, pretreatment of Caco-2 cells with glutamine and arginine, alone or combined, differently limited the decrease of ZO-1 and occludin expression (P &lt; 0.05) and the alteration of their cellular distribution, through c-Jun N-terminal kinase (JNK), Extracellular signal-regulated kinase (ERK) and nuclear factor kappa B (NF-kappaB) pathways.	Arginine	61-69	occludin	Homo sapiens	135-143
25795782-4	2015	This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4/VAV1/RAC1 NADPH oxidase complex.	Arginine	37-40	vav guanine nucleotide exchange factor 1	Homo sapiens	104-108
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	neutrophil cytosolic factor 2	Homo sapiens	71-75
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	neutrophil cytosolic factor 2	Homo sapiens	159-163
24284322-3	2014	Here we show that the EBNA1-nucleophosmin interaction is direct and requires the Gly-Arg-rich sequences that contribute to transactivation.	Arginine	85-88	nucleophosmin 1	Homo sapiens	28-41
24133491-6	2013	Arginase-1 seems to play an important role in limiting l-arginine availability in the close proximity of eNOS in vessels of DM patients.	Arginine	55-65	arginase 1	Homo sapiens	0-10
24338687-6	2014	X-ray crystallographic studies of chronophin(A194K,A195K) revealed that dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination.	Arginine	123-131	pyridoxal phosphatase	Homo sapiens	34-44
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	vav guanine nucleotide exchange factor 1	Homo sapiens	191-195
25875054-0	2015	Correction to GPR103 Antagonists Demonstrating Anorexigenic Activity in Vivo: Design and Development of Pyrrolo[2,3-c]pyridines That Mimic the C-Terminal Arg-Phe Motif of QRFP26.	Arginine	154-157	pyroglutamylated RFamide peptide receptor	Homo sapiens	14-20
25515928-4	2015	Conjugating RVG to a redox-sensitive biodegradable dendrimer-type arginine-grafted polymer (PAM-ABP) enabled nanoparticle formation with plasmid DNA without altering the environment-sensitive DNA release property and favorable toxicity profile of the parent polymer.	Arginine	66-74	amine oxidase copper containing 1	Homo sapiens	96-99
24465614-5	2014	NAGS (EC 2.3.1.1) catalyzes the formation of N-acetylglutamate from glutamate and acetyl coenzyme A and in zebrafish is partially inhibited by L-arginine.	Arginine	143-153	N-acetylglutamate synthase	Danio rerio	0-4
24465614-12	2014	The expression pattern of NAGS and other urea cycle genes in developing zebrafish suggests that they may have a role in citrulline and/or arginine biosynthesis during the first day of development and in ammonia detoxification thereafter.	Arginine	138-146	N-acetylglutamate synthase	Danio rerio	26-30
23928331-6	2013	In addition, supplementation of the storage culture medium with glucose and substrate (arginine) significantly stabilized the recombinant arginine deiminase producer.	Arginine	87-95	arginine deiminase	Escherichia coli	138-156
25946048-4	2015	Here we show that Abl family of non-receptor tyrosine kinases, comprised of Abl (ABL1) and Arg (ABL2), are activated downstream of the Met receptor, and that inhibition of Abl kinases dramatically suppresses HGF-induced cell scattering and tubulogenesis.	Arginine	91-94	hepatocyte growth factor	Homo sapiens	208-211
23884422-6	2013	Moreover, we demonstrate that there are three critical residues (Arg-130, Lys-170, and Lys-411) necessary for IPK1 activity.	Arginine	65-68	inositol-pentakisphosphate 2-kinase	Homo sapiens	110-114
23884422-7	2013	Arg-130 is the only substrate-binding N-terminal lobe residue that can render IPK1 inactive; its 1-phosphate is critical for full IPK1 activity and for stabilization of the active conformation of IPK1.	Arginine	0-3	inositol-pentakisphosphate 2-kinase	Homo sapiens	78-82
23884422-7	2013	Arg-130 is the only substrate-binding N-terminal lobe residue that can render IPK1 inactive; its 1-phosphate is critical for full IPK1 activity and for stabilization of the active conformation of IPK1.	Arginine	0-3	inositol-pentakisphosphate 2-kinase	Homo sapiens	130-134
23884422-7	2013	Arg-130 is the only substrate-binding N-terminal lobe residue that can render IPK1 inactive; its 1-phosphate is critical for full IPK1 activity and for stabilization of the active conformation of IPK1.	Arginine	0-3	inositol-pentakisphosphate 2-kinase	Homo sapiens	130-134
24140612-6	2014	While osteoclast activation occurred when pASP was used as the process-directing agent, using OPN resulted in a dramatic effect on osteoclast activation, presumably because of the inherent arginine-glycine-aspartate acid ligands of OPN.	Arginine	189-197	secreted phosphoprotein 1	Mus musculus	94-97
24140612-6	2014	While osteoclast activation occurred when pASP was used as the process-directing agent, using OPN resulted in a dramatic effect on osteoclast activation, presumably because of the inherent arginine-glycine-aspartate acid ligands of OPN.	Arginine	189-197	secreted phosphoprotein 1	Mus musculus	232-235
23884422-8	2013	Taken together, our results support the model for recognition of the IP substrate by IPK1 in which (i) the 4-, 5-, and 6-phosphates are initially recognized by the C-terminal lobe, and subsequently, (ii) the interaction between the 1-phosphate and Arg-130 stabilizes the N-terminal lobe and activates IPK1.	Arginine	248-251	inositol-pentakisphosphate 2-kinase	Homo sapiens	85-89
25126568-0	2014	Depletion of arginine by recombinant arginine deiminase induces nNOS-activated neurotoxicity in neuroblastoma cells.	Arginine	13-21	nitric oxide synthase 1	Homo sapiens	64-68
26259481-4	2015	RESULTS: Agp1p can be ubiquitinated on the medium with glutamine, arginine, proline or ammonium.	Arginine	66-74	amino acid transporter AGP1	Saccharomyces cerevisiae S288C	9-14
25126568-6	2014	NMDA increased NO production by 39.7 +- 3.9% via nNOS under arginine-containing conditions, but there was no significant increase in both arginine-free and rADI pretreated arginine-containing (citrulline) buffer.	Arginine	60-68	nitric oxide synthase 1	Homo sapiens	49-53
25022516-7	2014	Tumor uptake of (99m)TcO2-N4-CORe(Arg(11))CCMSH was 7.54+-1.82% ID/g and 2.28+-0.22% ID/g at 1 h and 2 h post injection, respectively.	Arginine	34-37	cytochrome c oxidase II, mitochondrial	Mus musculus	21-25
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	helicase for meiosis 1	Homo sapiens	0-8
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	helicase for meiosis 1	Homo sapiens	67-75
25772617-10	2015	We also found that cytosolic sequences of other LAMP family proteins, LAMP1 and CD68/LAMP4, also possess arginine residues, and show affinity for nucleic acids.	Arginine	105-113	lysosomal associated membrane protein 1	Homo sapiens	70-75
23692053-0	2013	Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias.	Arginine	52-60	neuron navigator 1	Homo sapiens	42-49
25070816-6	2014	RESULTS AND CONCLUSIONS: L-arginine enhanced ADI-induced inhibited cell growth through expression of NF-kappaBp65 and p53 in a dose-dependent manner.	Arginine	25-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	101-113
24249517-0	2015	Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.	Arginine	111-114	secreted phosphoprotein 1	Mus musculus	0-11
24522477-7	2014	L-arginine supplementation leads to redirection of AMP deamination on account of increased AMP dephosphorylation and subsequent adenosine production and may increase ATP regeneration via activation of AMP kinase (AMPK) pathway.	Arginine	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	201-211
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Arginine	215-218	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	123-126
24522477-7	2014	L-arginine supplementation leads to redirection of AMP deamination on account of increased AMP dephosphorylation and subsequent adenosine production and may increase ATP regeneration via activation of AMP kinase (AMPK) pathway.	Arginine	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	213-217
24249517-0	2015	Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.	Arginine	111-114	caspase 8	Homo sapiens	155-164
25680754-11	2015	Inhibition of pontin activity enhanced human receptor plasma membrane levels and signaling at 37 C. Our results demonstrate that human alpha2C-AR has a unique temperature-sensitive traffic pattern within the G protein-coupled receptor class due to interactions with different molecular chaperones, mediated in part by strict spatial localization of specific arginine residues.	Arginine	358-366	adrenoceptor alpha 2C	Homo sapiens	135-145
25030923-3	2014	Arginine-grafted bioreducible poly (disulfide amine) (ABP) is a redox-sensitive, bioreducible, positively charged polymer which complexes with siRNA and DNA via charge interactions to form nanoplexes.	Arginine	0-8	amine oxidase copper containing 1	Homo sapiens	54-57
25682972-17	2015	CONCLUSION: L-Arginine exerts its nephro- and cardio-protective potential in EG-induced urolithiasis in uninephrectomized hypertensive rats via modulation of KIM-1, NGAL, eNOS, and iNOs mRNA expression.	Arginine	12-22	lipocalin 2	Rattus norvegicus	165-169
24400007-3	2013	l-Citrulline (l-cit) supplementation not only increases l-arg synthesis, but also inhibits cytosolic arginase I, a competitor of eNOS for the use of l-arg, in the vasculature.	Arginine	149-154	arginase, liver	Mus musculus	101-111
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Arginine	140-143	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
23843458-7	2013	Specifically, several intermolecular ionic interactions between HER2 Lys-716-HER3 Glu-909, HER2 Glu-717-HER3 Lys-907, and HER2 Asp-871-HER3 Arg-948 were identified by molecular dynamics.	Arginine	140-143	erb-b2 receptor tyrosine kinase 3	Homo sapiens	104-108
25789405-11	2015	TM2 Arg residues at the matrix interface of UCP2 proved to be crucial for the protein"s anion transport function, and their absence resulted in highly diminished Cl(-) transport rates.	Arginine	4-7	uncoupling protein 2	Homo sapiens	44-48
23831350-0	2013	Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.	Arginine	64-72	protein arginine methyltransferase 5	Rattus norvegicus	41-46
23831350-0	2013	Differential regulation of SC1/PRDM4 and PRMT5 mediated protein arginine methylation by the nerve growth factor and the epidermal growth factor in PC12 cells.	Arginine	64-72	nerve growth factor	Rattus norvegicus	92-111
24300896-2	2013	We report the methylation of VEGFR-2 at multiple Lys and Arg residues, including Lys(1041), a residue that is proximal to the activation loop of the kinase domain.	Arginine	57-60	kinase insert domain protein receptor	Mus musculus	29-36
24100225-0	2013	Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP.	Arginine	45-53	valosin containing protein	Homo sapiens	100-107
25557051-1	2015	The purpose of this study was to examine whether the replacement of the positively-charged Lys or Arg linker with a neutral linker could reduce the renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide.	Arginine	98-101	pro-opiomelanocortin-alpha	Mus musculus	193-229
23859953-1	2013	Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS.	Arginine	52-62	nitric oxide synthase 1	Homo sapiens	117-121
23859953-1	2013	Nitric oxide (NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO synthase isoforms, iNOS, eNOS and nNOS.	Arginine	64-69	nitric oxide synthase 1	Homo sapiens	117-121
23199242-6	2013	Knockdown of nNOS in melanoma cells diminished L-arginine-induced NO production; the metastatic capacity was also reduced as well as the levels of MMP-1, Bcl-2, JunD, and APE/Ref-1.	Arginine	47-57	nitric oxide synthase 1	Homo sapiens	13-17
23199242-6	2013	Knockdown of nNOS in melanoma cells diminished L-arginine-induced NO production; the metastatic capacity was also reduced as well as the levels of MMP-1, Bcl-2, JunD, and APE/Ref-1.	Arginine	47-57	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	175-180
25557051-1	2015	The purpose of this study was to examine whether the replacement of the positively-charged Lys or Arg linker with a neutral linker could reduce the renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide.	Arginine	164-167	pro-opiomelanocortin-alpha	Mus musculus	193-229
24187844-7	2013	The result confirmed that the uptake of ACS was enhanced with increased substitution degree of arginine by 4-8 folds compared to chitosan.	Arginine	95-103	acyl-CoA synthetase short chain family member 2	Homo sapiens	40-43
24183975-1	2013	Two distinct enzymes of arginase (1 and 2) are critically regulating nitric oxide (NO) bioavailability by competing with NO synthase for their common substrate l-arginine.	Arginine	160-170	arginase 1	Homo sapiens	24-41
25557051-1	2015	The purpose of this study was to examine whether the replacement of the positively-charged Lys or Arg linker with a neutral linker could reduce the renal uptake of Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptide.	Arginine	164-167	pro-opiomelanocortin-alpha	Mus musculus	231-240
24728914-2	2015	We examined the concept that expression levels of endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil integrins Mac-1 and LFA-1 are modulated by the kinin B1 receptor (B1R) agonist, Lys-des[Arg(9)]bradykinin (LDBK).	Arginine	208-211	integrin subunit alpha L	Homo sapiens	140-145
24100041-5	2013	Double knockdown of the serine/arginine-rich (SR)-like proteins BCLAF1 and THRAP3 by siRNA resulted in a decrease in the nuclear speckle localization of WTAP, whereas the nuclear speckles were intact.	Arginine	31-39	WT1 associated protein	Homo sapiens	153-157
23745796-3	2013	A crystal structure of the Arabidopsis thaliana tryptophan-rich wild type UVR8 protein dimer was recently published, showing the presence of several salt bridges involving arginines R146, R286, R338, and R354.	Arginine	172-181	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	74-78
25676786-11	2015	Arginine 493 is conserved among multiple species and all human nuclear receptors and its mutation has also been found in the human GR, androgen receptor, and mineralocorticoid receptor.	Arginine	0-8	nuclear receptor subfamily 3 group C member 2	Homo sapiens	158-184
23796461-1	2013	Heterozygous mutations in catalytic arginine residues of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are common in glioma, acute myeloid leukemia, chondrosarcoma, cholangiocarcinoma, and angioimmunoblastic T-cell lymphoma.	Arginine	36-44	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	101-105
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Arginine	187-190	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	99-102
24092756-6	2013	We identified a group of residues at the juxtamembrane regions of the intracellular loops 2 and 3 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32), Leu-341(6.33), and Thr-344(6.36), as potential key contacts with the extreme C-terminal helix alpha5 of Galphai.	Arginine	187-190	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	166-169
24204711-8	2013	Urea and NO levels were significantly higher in UT-B null urothelium than that in wild-type, which may affect L-arginine metabolism and the intracellular signals related to DNA damage and apoptosis.	Arginine	110-120	solute carrier family 14 (urea transporter), member 1	Mus musculus	48-52
25766235-4	2015	The shortest-lived mutant, ML-Rgs2, was targeted by both the Ac/N-end rule and Arg/N-end rule pathways.	Arginine	79-82	regulator of G protein signaling 2	Homo sapiens	30-34
23806842-4	2013	We demonstrated that intramyocardial delivery of phEPO by an arginine-grafted poly(disulfide amine) (ABP) polymer in infarcted rats preserves cardiac geometry and systolic function.	Arginine	61-69	amine oxidase, copper containing 1	Rattus norvegicus	101-104
25206468-0	2013	Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons.	Arginine	0-3	gonadotropin releasing hormone 1	Homo sapiens	41-71
25766235-6	2015	Thus, the Nt-acetylated Ac-MX-Rgs2 (X = Arg, Gln, Leu) proteins are specific substrates of the mammalian Ac/N-end rule pathway.	Arginine	40-43	regulator of G protein signaling 2	Homo sapiens	30-34
25737013-5	2015	Methylation of SAP145 on Arg 508 generates a binding site for the Tudor domain of the Survival of Motor Neuron (SMN) protein, and RNA-seq analysis reveals gross splicing changes when PRMT9 levels are attenuated.	Arginine	25-28	survival of motor neuron 1, telomeric	Homo sapiens	86-110
25206468-8	2013	Co-treatment of kisspeptin with 1 mumol/L gonadotropin-inhibitory hormone or 1 mumol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration.	Arginine	87-90	gonadotropin releasing hormone 1	Homo sapiens	173-203
25737013-5	2015	Methylation of SAP145 on Arg 508 generates a binding site for the Tudor domain of the Survival of Motor Neuron (SMN) protein, and RNA-seq analysis reveals gross splicing changes when PRMT9 levels are attenuated.	Arginine	25-28	survival of motor neuron 1, telomeric	Homo sapiens	112-115
25680633-2	2015	To improve cell attachment, arginine-glycine-aspartic acid-serine (RGDS) peptides were covalently grafted to chitosan films, through the widely used coupling agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC-HCl) and N-hydroxysuccinimide (NHS), via the carboxylic acid function of the RGDS molecule.	Arginine	28-36	ral guanine nucleotide dissociation stimulator	Homo sapiens	67-71
23840444-6	2013	Among them, Arginine was the most effective and was verified by in vitro assays as a potent re-folder of pVHL.	Arginine	12-20	von Hippel-Lindau tumor suppressor	Homo sapiens	105-109
23902829-8	2013	The mutation of two amino acids in the CDR2 region to arginine and/or aspartic acid increased the affinity by decreasing the dissociation rate.	Arginine	54-62	cerebellar degeneration related protein 2	Homo sapiens	39-43
25680633-2	2015	To improve cell attachment, arginine-glycine-aspartic acid-serine (RGDS) peptides were covalently grafted to chitosan films, through the widely used coupling agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC-HCl) and N-hydroxysuccinimide (NHS), via the carboxylic acid function of the RGDS molecule.	Arginine	28-36	ral guanine nucleotide dissociation stimulator	Homo sapiens	293-297
25619998-5	2015	Ser1 and Arg3 of the histone make extensive contacts to highly conserved NatD residues in the substrate binding pocket, and flanking glycine residues also appear to contribute to substrate-specific binding by NatD, together defining a Ser-Gly-Arg-Gly recognition sequence.	Arginine	9-12	N-alpha-acetyltransferase 10, NatA catalytic subunit	Homo sapiens	73-77
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Arginine	163-166	CLAVATA3	Arabidopsis thaliana	17-21
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Arginine	163-166	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	59-63
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Arginine	163-166	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
23912193-3	2013	An active mature CLV3 is a tridecapeptide linked to beta-L-Araf-(1 2)-beta-L-Araf-(1 2)-beta-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3).	Arginine	163-166	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	77-81
23750482-2	2013	IDH1 mutations, which are specific to a single codon in the conserved and functionally important Arginine 132 (R132), result in the ability of the enzyme to catalyze the reduced NADP-dependent reduction of alpha-ketoglutarate to onco-metabolite R(-)-2-hydroxyglutarate (2-HG).	Arginine	97-105	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-4
23718875-10	2013	Long-term exposure of ARG with or without CMP-C or L-NAME suppressed NO2-/NO3-, glucose uptake, GLUT-1, AMPK expression and activity below control, and increased overall cellular glucose, O2 - and ONOO-.	Arginine	22-25	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	104-108
23718875-12	2013	Continuous co-incubation with CDB and ARG increased NO2-/NO3-, glucose uptake, GLUT-1, AMPK expression and activity, and maintained overall cellular glucose, O2 - and ONOO- to control conditions.	Arginine	38-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	87-91
25550342-7	2015	However, an additive effect on oTr1 cell proliferation was induced by combination of arginine and SPP1 as compared to the control (2.1-fold increase; P &lt; 0.01), arginine alone (1.3-fold increase; P &lt; 0.05), and rSPP1 alone (1.5-fold increase; P &lt; 0.01).	Arginine	85-93	secreted phosphoprotein 1	Rattus norvegicus	217-222
23718875-13	2013	CONCLUSION: The present study provides the fundamental evidence for AMPK as the primary modulator of ARG cellular responses and for regulating the mode of glucose accumulation during short-term and continuous ARG treatments.	Arginine	101-104	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	68-72
23718875-13	2013	CONCLUSION: The present study provides the fundamental evidence for AMPK as the primary modulator of ARG cellular responses and for regulating the mode of glucose accumulation during short-term and continuous ARG treatments.	Arginine	209-212	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	68-72
23888046-2	2013	In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium.	Arginine	179-187	glutamyl aminopeptidase	Homo sapiens	56-72
23888046-2	2013	In the central renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by specifically cleaving the N-terminal aspartate, but not the adjacent arginine, from angiotensin II, a process facilitated by calcium.	Arginine	179-187	glutamyl aminopeptidase	Homo sapiens	74-77
25462857-6	2015	ADI-SPA(20 kDa) injections via intravenous, intramuscular and subcutaneous routes all exhibited superior efficacy than native ADI on depleting serum arginine.	Arginine	149-157	surfactant associated protein A1	Mus musculus	4-7
23707382-2	2013	Prior studies have shown that cytoplasmic-nuclear translocalization of the SR protein SRSF1 is regulated by multisite phosphorylation of a long Arg-Ser repeat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation of a shorter Arg-Ser repeat along with several Ser-Pro dipeptides in the C-terminus of the RS domain.	Arginine	144-147	RNA binding protein with serine rich domain 1	Homo sapiens	75-85
23707382-2	2013	Prior studies have shown that cytoplasmic-nuclear translocalization of the SR protein SRSF1 is regulated by multisite phosphorylation of a long Arg-Ser repeat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation of a shorter Arg-Ser repeat along with several Ser-Pro dipeptides in the C-terminus of the RS domain.	Arginine	270-273	RNA binding protein with serine rich domain 1	Homo sapiens	75-85
23707382-5	2013	While SRPK1 rapidly phosphorylates N-terminal serines, SRPK1 and CLK1 display similar activities toward Arg-Ser repeats in the C-terminus, suggesting that these kinases may not separate function in a strict linear manner along the RS domain.	Arginine	104-107	SRSF protein kinase 1	Homo sapiens	55-60
23707382-5	2013	While SRPK1 rapidly phosphorylates N-terminal serines, SRPK1 and CLK1 display similar activities toward Arg-Ser repeats in the C-terminus, suggesting that these kinases may not separate function in a strict linear manner along the RS domain.	Arginine	104-107	CDC like kinase 1	Homo sapiens	65-69
23707382-6	2013	CLK1 induces a unique gel shift in SRSF1 that is not the result of enhanced Arg-Ser phosphorylation but rather is the direct result of the phosphorylation of several Ser-Pro dipeptides.	Arginine	76-79	CDC like kinase 1	Homo sapiens	0-4
23586781-1	2013	Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline through the intermediate N(omega)-hydroxy-L-arginine (NHA), producing nitric oxide, an important mammalian signaling molecule.	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	0-21
23642268-7	2013	Three identified proteins: splicing factor, proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences.	Arginine	214-222	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	142-179
23642268-7	2013	Three identified proteins: splicing factor, proline- and glutamine-rich (SFPQ), heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and cellular nucleic acid binding protein (CNBP) are known to contain methylarginines in their glycine and arginine rich (GAR) sequences.	Arginine	214-222	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	181-185
25462857-7	2015	Additionally, our results demonstrated that single ADI-SPA(20 kDa) administration of 5 U/mouse via intravenous injection could maintain serum arginine at an undetectable level for 5 days with a half-life of 53.2 h, representing 11-fold improvement in half-life than that of the native ADI.	Arginine	142-150	surfactant associated protein A1	Mus musculus	55-58
24746974-14	2015	Arginine might be responsible for some, but not all of the beneficial effects of lupin protein.	Arginine	0-8	5'-nucleotidase, cytosolic IIIA	Homo sapiens	81-86
23642268-13	2013	CONCLUSION: Our study showed that hnRNP DL and CNBP are novel antigens for SLE patients and the recognition of CNBP might be differentiated dependent on the level of arginine methylation.	Arginine	166-174	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	111-115
23904475-4	2013	We now report that, in response to IL-1beta, the p65 subunit of NF-kappaB is dimethylated on arginine 30 (R30) by protein-arginine methyltransferase 5 (PRMT5).	Arginine	93-101	RELA proto-oncogene, NF-kB subunit	Homo sapiens	49-73
25468444-3	2015	IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-Asp (RGD) sequence, and IGFBP-1 has been shown by others to stimulate migration through binding of its RGD sequence to alpha5beta1 integrin.	Arginine	38-41	insulin like growth factor binding protein 2	Homo sapiens	12-19
23628706-11	2013	CONCLUSIONS: HCD effectively interacted at the autophosphorylation site of FAK and interaction analysis indicated an H-bond with the Arg 86 and Arg 125 residues.	Arginine	133-136	protein tyrosine kinase 2	Homo sapiens	75-78
23628706-11	2013	CONCLUSIONS: HCD effectively interacted at the autophosphorylation site of FAK and interaction analysis indicated an H-bond with the Arg 86 and Arg 125 residues.	Arginine	144-147	protein tyrosine kinase 2	Homo sapiens	75-78
23645728-2	2013	A1-R is auxotrophic for leu and arg which attenuates bacterial growth in normal tissue but allows high tumor virulence.	Arginine	32-35	adenosine A1 receptor	Mus musculus	0-4
25480793-9	2015	We show that the presence of an arginine rather than serine 512 provoked transporter misfolding, enhanced association to the ER-chaperone calnexin, altered association with the coat-protein complex II component Sec24D, and thereby impeded ER exit.	Arginine	32-40	calnexin	Homo sapiens	138-146
23689135-4	2013	This work identified the arginine residue at position 68 of L13a as being essential for L13a binding to rRNA and incorporation into ribosomes.	Arginine	25-33	ribosomal protein L13a	Homo sapiens	60-64
23689135-4	2013	This work identified the arginine residue at position 68 of L13a as being essential for L13a binding to rRNA and incorporation into ribosomes.	Arginine	25-33	ribosomal protein L13a	Homo sapiens	88-92
25203060-4	2015	We show that p300/CBP associated factor (PCAF)/GCN5 activity depends on the presence of a distal arginine residue of its histone H3 substrate.	Arginine	97-105	E1A binding protein p300	Homo sapiens	13-17
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Arginine	41-51	arginase 1	Homo sapiens	15-19
25203060-4	2015	We show that p300/CBP associated factor (PCAF)/GCN5 activity depends on the presence of a distal arginine residue of its histone H3 substrate.	Arginine	97-105	lysine acetyltransferase 2B	Homo sapiens	41-45
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Arginine	210-220	arginase 1	Homo sapiens	15-19
25203060-5	2015	Modifications to H3 Arg8 decrease PCAF acetylation of H3 Lys14, and kinetic data indicate that arginine citrullination has the strongest effect in decreasing acetylation.	Arginine	95-103	lysine acetyltransferase 2B	Homo sapiens	34-38
25451930-2	2015	One of the most intensely studied examples is a hyperfunctional variant of the human beta1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1).	Arginine	120-128	adrenoceptor beta 1	Homo sapiens	85-103
23874440-1	2013	Nitric oxide, produced by the neuronal nitric oxide synthase (nNOS) from L-arginine is an important second messenger molecule in the central nervous system: It influences the synthesis and release of neurotransmitters and plays an important role in long-term potentiation, long-term depression and neuroendocrine secretion.	Arginine	73-83	nitric oxide synthase 1	Homo sapiens	30-60
23874440-1	2013	Nitric oxide, produced by the neuronal nitric oxide synthase (nNOS) from L-arginine is an important second messenger molecule in the central nervous system: It influences the synthesis and release of neurotransmitters and plays an important role in long-term potentiation, long-term depression and neuroendocrine secretion.	Arginine	73-83	nitric oxide synthase 1	Homo sapiens	62-66
23874440-5	2013	Measuring bioactive NO via cGMP formation in reporter cells, we demonstrate here that nNOS in both, human A673 neuroepithelioma and TGW-nu-I neuroblastoma cells can be fast and efficiently nourished by extracellular arginine that enters the cells via membrane transporters (pool I that is freely exchangeable with the extracellular space).	Arginine	216-224	nitric oxide synthase 1	Homo sapiens	86-90
23874440-9	2013	Histidine mimicked the effect of protease inhibitors causing an almost complete nNOS inhibition in cells incubated additionally in lysine that depletes the exchangeable arginine pool.	Arginine	169-177	nitric oxide synthase 1	Homo sapiens	80-84
25451930-2	2015	One of the most intensely studied examples is a hyperfunctional variant of the human beta1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1).	Arginine	120-128	adrenoceptor beta 1	Homo sapiens	165-170
25451930-2	2015	One of the most intensely studied examples is a hyperfunctional variant of the human beta1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1).	Arginine	157-160	adrenoceptor beta 1	Homo sapiens	85-103
25451930-2	2015	One of the most intensely studied examples is a hyperfunctional variant of the human beta1-adrenoceptor that carries an arginine at position 389 in helix 8 (Arg-389-ADRB1).	Arginine	157-160	adrenoceptor beta 1	Homo sapiens	165-170
23317684-0	2013	Description of a novel TUBA1A mutation in Arg-390 associated with asymmetrical polymicrogyria and mid-hindbrain dysgenesis.	Arginine	42-45	tubulin alpha 1a	Homo sapiens	23-29
25451930-4	2015	Despite its hyperfunctionality, we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with norepinephrine compared with the Gly-389 variant.	Arginine	45-48	adrenoceptor beta 1	Homo sapiens	64-69
25451930-5	2015	Using ADRB1 sensors to monitor activation kinetics by fluorescence resonance energy transfer, Arg-389-ADRB1 exerted faster activation speed and arrestin recruitment than the Gly-389 variant.	Arginine	94-97	adrenoceptor beta 1	Homo sapiens	6-11
25451930-5	2015	Using ADRB1 sensors to monitor activation kinetics by fluorescence resonance energy transfer, Arg-389-ADRB1 exerted faster activation speed and arrestin recruitment than the Gly-389 variant.	Arginine	94-97	adrenoceptor beta 1	Homo sapiens	102-107
25451930-7	2015	Structural modeling of the human beta1-adrenoceptor suggested interaction of the side chain of Arg-389 with opposing amino acid residues in helix 1.	Arginine	95-98	adrenoceptor beta 1	Homo sapiens	33-51
23670531-10	2013	Substitution of Arg for Pro in the N-terminal alpha-helix altered net charge and reduced apoC-I affinity for POPC/TO/W interfaces.	Arginine	16-19	apolipoprotein C1	Homo sapiens	89-95
25480565-8	2015	Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding.	Arginine	81-84	BW6	Homo sapiens	139-142
25567906-1	2015	Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.	Arginine	49-57	CREB regulated transcription coactivator 1	Mus musculus	73-79
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Arginine	76-86	arginase 1	Homo sapiens	0-10
23375628-3	2013	Arginase 1 (Arg1), a marker for the M2 anti-inflammatory subset, hydrolyzes l-arginine into urea and ornithine, a precursor to l-proline and polyamines, which are implicated in tissue repair and wound healing.	Arginine	76-86	arginase 1	Homo sapiens	12-16
23375628-4	2013	Additionally, Arg1 inhibits nitric oxide-mediated inflammatory pathways by competing with iNOS for the same substrate, l-arginine.	Arginine	119-129	arginase 1	Homo sapiens	14-18
23659383-10	2013	Mutation of Arg2116 to hydrophobic residues resulted in variable decreases in stability and thrombin generation parameters, suggesting a role of this Arg residue contributing to FVIII structure.	Arginine	12-15	coagulation factor VIII	Homo sapiens	178-183
25567906-5	2015	SLC38A9 transports arginine with a high Michaelis constant, and loss of SLC38A9 represses mTORC1 activation by amino acids, particularly arginine.	Arginine	19-27	CREB regulated transcription coactivator 1	Mus musculus	90-96
25567906-5	2015	SLC38A9 transports arginine with a high Michaelis constant, and loss of SLC38A9 represses mTORC1 activation by amino acids, particularly arginine.	Arginine	137-145	CREB regulated transcription coactivator 1	Mus musculus	90-96
25567906-7	2015	Thus, SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.	Arginine	95-103	CREB regulated transcription coactivator 1	Mus musculus	119-125
25635535-4	2015	Silencing Arg-II or p38alpha in senescent cells recouples eNOS and inhibits IL-6 and IL-8 secretion.	Arginine	10-13	chemokine (C-X-C motif) ligand 15	Mus musculus	85-89
23521092-8	2013	FVIII variants where Arg(1719) or Arg(1721) were mutated to aspartate showed a &gt;40-fold reduction in membrane affinity.	Arginine	21-24	coagulation factor VIII	Homo sapiens	0-5
23718875-0	2013	AMP-activated protein kinase regulates L-arginine mediated cellular responses.	Arginine	39-49	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-28
25635535-6	2015	Moreover, p38 activation and expression of IL-6 and KC (the murine IL-8 homologue) are increased in the heart and/or aortas of wild type (WT) old mice, which is abolished in mice with Arg-II gene deficiency (Arg-II-/-).	Arginine	184-187	mitogen-activated protein kinase 14	Mus musculus	10-13
25635535-6	2015	Moreover, p38 activation and expression of IL-6 and KC (the murine IL-8 homologue) are increased in the heart and/or aortas of wild type (WT) old mice, which is abolished in mice with Arg-II gene deficiency (Arg-II-/-).	Arginine	184-187	chemokine (C-X-C motif) ligand 15	Mus musculus	67-71
25205713-9	2015	Arg and Lys residues located within the 40 residue spanning connecting peptide of fetuin-A were identified as cleavage sites for matriptase-2.	Arginine	0-3	transmembrane serine protease 6	Mus musculus	129-141
23486913-5	2013	Primary porcine trophectoderm (pTr) cells treated with either Arg, Leu, or Gln had increased abundance of phosphorylated RPS6K, RPS6, and EIF4EBP1 compared to basal levels, and this effect was maintained for up to 120 min.	Arginine	62-65	ribosomal protein S6	Sus scrofa	121-125
23486913-5	2013	Primary porcine trophectoderm (pTr) cells treated with either Arg, Leu, or Gln had increased abundance of phosphorylated RPS6K, RPS6, and EIF4EBP1 compared to basal levels, and this effect was maintained for up to 120 min.	Arginine	62-65	eukaryotic translation initiation factor 4E binding protein 1	Sus scrofa	138-146
23486913-10	2013	Collectively, these results indicate that Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	42-45	ribosomal protein S6	Sus scrofa	148-152
23486913-10	2013	Collectively, these results indicate that Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	42-45	eukaryotic translation initiation factor 4E binding protein 1	Sus scrofa	159-167
25286108-8	2015	We found that their C-terminal regions, particularly the two tryptophan residues (Trp462 and Trp469) of ALDH3B2 and the two arginine residues (Arg462 and Arg463) of ALDH3B3, were important for the determination of their specific localization.	Arginine	124-132	aldehyde dehydrogenase 3 family, member B3	Mus musculus	165-172
23617280-3	2013	A diagnosis of CTLN2 was made by DNA analysis of the SLC25A13 gene and treatment with conservative therapies was begun, including a low-carbohydrate diet and supplementation with arginine and sodium pyruvate.	Arginine	179-187	solute carrier family 25 member 13	Homo sapiens	15-20
25747984-8	2015	Taking these results into consideration, it appears that CAT1 is involved in L-Arg uptake by retinal pericytes and this is expected to play an important role in the relaxation of retinal pericytes, thereby modulating the microcirculatory hemodynamics in the retina.	Arginine	77-82	solute carrier family 7 member 1	Rattus norvegicus	57-61
23462506-2	2013	To understand the molecular mechanisms and the subsequent effects in modulating FXR functions in diverse biologic processes, we individually replaced eight highly conserved lysine residues of human FXR (hFXR) with arginine.	Arginine	214-222	nuclear receptor subfamily 1 group H member 4	Homo sapiens	198-201
23462506-2	2013	To understand the molecular mechanisms and the subsequent effects in modulating FXR functions in diverse biologic processes, we individually replaced eight highly conserved lysine residues of human FXR (hFXR) with arginine.	Arginine	214-222	nuclear receptor subfamily 1 group H member 4	Homo sapiens	203-207
26662652-9	2015	L-arg supplementation protected against increases in MMP-2 and MMP-9 in Group 3 (A) and 4 (AC).	Arginine	0-5	matrix metallopeptidase 2	Rattus norvegicus	53-58
23470718-2	2013	NO and polyamines are metabolized from arginine through NO synthase (NOS) and arginine decarboxylase (ADC), respectively.	Arginine	39-47	arginine decarboxylase 1	Arabidopsis thaliana	78-100
23470718-2	2013	NO and polyamines are metabolized from arginine through NO synthase (NOS) and arginine decarboxylase (ADC), respectively.	Arginine	39-47	arginine decarboxylase 1	Arabidopsis thaliana	102-105
26662652-10	2015	CONCLUSIONS: L-arginine could protect from an increase in visceral fat through a change in the activity of MMPs and amelioration of insulin sensitivity in rats fed a HFD.	Arginine	13-23	matrix metallopeptidase 2	Rattus norvegicus	107-111
23592920-17	2013	Sequencing of the 12 coding exons and splice sites of CRB1 disclosed a homozygous missense mutation in exon 7 at nucleotide c. 2291G&gt;A, resulting in an arginine to histidine substitution (p.R764H).	Arginine	155-163	crumbs cell polarity complex component 1	Homo sapiens	54-58
25445211-2	2015	SRSF2 is a member of the serine/arginine-rich family pre-mRNA splicing factors that plays a role in mRNA export from the nucleus and translation.	Arginine	32-40	serine and arginine rich splicing factor 2	Homo sapiens	0-5
23295407-12	2013	CONCLUSION: Melatonin inhibits PKC-alpha to increase cationic amino acid transporter-1 (CAT-1)-mediated L-arginine uptake in BDL liver, whereas it inhibits PKC-beta to reduce NADPH-dependent superoxide production.	Arginine	104-114	solute carrier family 7 member 1	Rattus norvegicus	53-86
23295407-12	2013	CONCLUSION: Melatonin inhibits PKC-alpha to increase cationic amino acid transporter-1 (CAT-1)-mediated L-arginine uptake in BDL liver, whereas it inhibits PKC-beta to reduce NADPH-dependent superoxide production.	Arginine	104-114	solute carrier family 7 member 1	Rattus norvegicus	88-93
23517528-6	2013	SDS-PAGE analysis revealed that APCC sequentially proteolyzed the heavy chain of FVIII at Arg(372) and Arg(740) , followed by cleavage at Arg(336) .	Arginine	90-93	coagulation factor VIII	Homo sapiens	81-86
25417848-10	2015	This mutation results in a deleterious amino acid substitution (p.Arg448Trp) of a highly conserved arginine residue in the rBAT protein encoded by the SLC3A1 gene.	Arginine	99-107	solute carrier family 3 member 1	Felis catus	151-157
23355387-7	2013	Furthermore, protein arginine methyltransferase (PRMT5) interacts with TDH and mediates its post-translational arginine methylation.	Arginine	21-29	protein arginine N-methyltransferase 5	Mus musculus	49-54
23355387-7	2013	Furthermore, protein arginine methyltransferase (PRMT5) interacts with TDH and mediates its post-translational arginine methylation.	Arginine	21-29	L-threonine dehydrogenase	Mus musculus	71-74
23352388-2	2013	Two recent structures of C2H2 zinc finger (ZnF) proteins in complex with methylated DNA reveal a common recognition mode for 5-methylcytosine (5mC) that involves a 5mC-Arg-G triad.	Arginine	168-171	zinc finger protein 763	Homo sapiens	43-46
23352388-3	2013	In the two ZnF proteins, an arginine that precedes the first Zn-binding histidine (RH motif) can interact with a 5mCpG or TpG dinucleotide.	Arginine	28-36	zinc finger protein 763	Homo sapiens	11-14
23335559-6	2013	Mutation of Lys-5-57 to arginines prevented binding of the VCP-UBXD1 complex and, importantly, strongly reduced recruitment of VCP-UBXD1 to endocytic compartments.	Arginine	24-33	valosin containing protein	Homo sapiens	59-62
25284001-2	2015	Cargo proteins interact with the importin-alpha armadillo repeat domain via nuclear localization sequences (NLSs), short amino acids motifs enriched in Lys and Arg residues.	Arginine	160-163	importin alpha 	Arabidopsis thaliana	33-47
23335559-6	2013	Mutation of Lys-5-57 to arginines prevented binding of the VCP-UBXD1 complex and, importantly, strongly reduced recruitment of VCP-UBXD1 to endocytic compartments.	Arginine	24-33	valosin containing protein	Homo sapiens	127-130
23554496-6	2013	A single amino acid mutation at position 1008 in the C terminus of TRPM8 (arginine to glutamine) also attenuated changes in the cold temperature threshold induced by ambient temperature.	Arginine	74-82	transient receptor potential cation channel subfamily M member 8	Homo sapiens	67-72
25307852-2	2015	Among bacterial proteins having this range of sequence similarity to mammalian CDO are some that conserve an active site Arg residue ("Arg-type" enzymes) and some having a Gln substituted for this Arg ("Gln-type" enzymes).	Arginine	121-124	cysteine dioxygenase type 1	Rattus norvegicus	79-82
23530137-8	2013	Each Arg residue in the S4 helix of hH(V)1 was replaced by His to test accessibility using Zn(2+) as a probe.	Arginine	5-8	hydrogen voltage gated channel 1	Homo sapiens	36-42
23530137-10	2013	Both modeling and experimental data indicate that in the open state, Arg(211), the third Arg residue in the S4 helix in hH(V)1, remains accessible to the internal solution and is located near the charge transfer center, Phe(150).	Arginine	69-72	hydrogen voltage gated channel 1	Homo sapiens	120-126
22961935-3	2013	Herein, we prepared RGDS peptide photocaged either on the Arg-Gly backbone amide nitrogen atom (R[-]GDS) or Asp side chain carboxyl (RG[D]S).	Arginine	58-61	ral guanine nucleotide dissociation stimulator	Homo sapiens	20-24
23530137-10	2013	Both modeling and experimental data indicate that in the open state, Arg(211), the third Arg residue in the S4 helix in hH(V)1, remains accessible to the internal solution and is located near the charge transfer center, Phe(150).	Arginine	89-92	hydrogen voltage gated channel 1	Homo sapiens	120-126
25307852-2	2015	Among bacterial proteins having this range of sequence similarity to mammalian CDO are some that conserve an active site Arg residue ("Arg-type" enzymes) and some having a Gln substituted for this Arg ("Gln-type" enzymes).	Arginine	135-138	cysteine dioxygenase type 1	Rattus norvegicus	79-82
25307852-2	2015	Among bacterial proteins having this range of sequence similarity to mammalian CDO are some that conserve an active site Arg residue ("Arg-type" enzymes) and some having a Gln substituted for this Arg ("Gln-type" enzymes).	Arginine	135-138	cysteine dioxygenase type 1	Rattus norvegicus	79-82
25521377-0	2014	Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.	Arginine	18-26	C9orf72-SMCR8 complex subunit	Homo sapiens	52-59
23416615-3	2013	Monoubiquitinated MALT1 had enhanced protease activity, whereas a ubiquitination-deficient MALT1 mutant with replacement of that lysine with arginine (MALT1(K644R)) had less protease activity, which correlated with impaired induction of interleukin 2 (IL-2) via the T cell antigen receptor in activated T cells.	Arginine	141-149	MALT1 paracaspase	Homo sapiens	91-96
23416615-3	2013	Monoubiquitinated MALT1 had enhanced protease activity, whereas a ubiquitination-deficient MALT1 mutant with replacement of that lysine with arginine (MALT1(K644R)) had less protease activity, which correlated with impaired induction of interleukin 2 (IL-2) via the T cell antigen receptor in activated T cells.	Arginine	141-149	MALT1 paracaspase	Homo sapiens	91-96
23269673-1	2013	Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg)   N-hydroxy-L-arginine   citrulline + NO.	Arginine	90-100	nitric oxide synthase 1, neuronal	Mus musculus	0-21
23269673-1	2013	Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: L-arginine (L-Arg)   N-hydroxy-L-arginine   citrulline + NO.	Arginine	102-107	nitric oxide synthase 1, neuronal	Mus musculus	0-21
23322784-2	2013	S. aureus is among the few bacterial species that express nitric-oxide synthase (bNOS) and thus can catalyze NO production from L-arginine.	Arginine	128-138	nitric oxide synthase 1	Homo sapiens	81-85
25096520-0	2014	Arginine protects muscle cells from wasting in vitro in an mTORC1-dependent and NO-independent manner.	Arginine	0-8	CREB regulated transcription coactivator 1	Mus musculus	59-65
23318500-2	2013	Linked by a specific disulfide bond (Cys(100)-Cys(650)), the N-terminal (N(t)) and the EC3 loop C-terminal (C(t)) segments of angiotensin II (AngII) receptor 1 (AT(1)R) have been identified to form an extracellular site for binding the agonist N(t) segment (Asp(1) and Arg(2) residues).	Arginine	269-272	angiotensin II receptor type 1	Homo sapiens	126-167
25096520-9	2014	The activation of mTORC1 and protein synthesis by arginine was not associated with changes in the phosphorylation status of Akt, but rather increased the expression of the amino acid-sensitive type III PI3-kinase Vps34 signalling protein.	Arginine	50-58	CREB regulated transcription coactivator 1	Mus musculus	18-24
23341458-6	2013	N-terminal sequencing indicated that pro-BMP-2 was cleaved by FSAP at the canonical PC cleavage site, giving rise to mature BMP-2 (Arg(282) Gln(283)), as well as in the N-terminal heparin binding region of mature BMP-2, generating a truncated mature BMP-2 peptide (Arg(289) Lys(290)).	Arginine	131-134	bone morphogenetic protein 2	Homo sapiens	41-46
25096520-9	2014	The activation of mTORC1 and protein synthesis by arginine was not associated with changes in the phosphorylation status of Akt, but rather increased the expression of the amino acid-sensitive type III PI3-kinase Vps34 signalling protein.	Arginine	50-58	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	213-218
23305409-5	2013	Analysis of a series of single-residue alanine mutants of EmBP-1 revealed that this effect is mediated by arginine 10.	Arginine	106-114	embigin pseudogene 1	Homo sapiens	58-64
25096520-10	2014	These data support a direct role for arginine in the regulation of mTORC1 in skeletal muscle.	Arginine	37-45	CREB regulated transcription coactivator 1	Mus musculus	67-73
25245031-8	2014	CONCLUSIONS: These genome-wide association study support the importance of DDAH1 and MED23/Arg1 in regulating ADMA and l-arginine metabolism, respectively, and identify a novel regulatory renal pathway for SDMA by AGXT2.	Arginine	119-129	arginase 1	Homo sapiens	91-95
23245960-6	2013	Using the DNA pooling sequencing approach, a missense single nucleotide polymorphism that replaces a histidine amino acid with an arginine was detected in exon 3 of PROP1.	Arginine	130-138	PROP paired-like homeobox 1	Bos taurus	165-170
22889511-6	2013	RESULTS: Arg-treatment increased: 1) basal and insulin-stimulated glycogen synthesis; 2) glucose uptake; 3) palmitate oxidation; 4) p-Akt (Ser(473)), total and plasma membrane GLUT4 content, total and p-AMPK-alpha and p-ACC (Ser(79)), p-GSK-3alpha/beta (Ser(21/9)) and 5) nitrite and c-GMP levels.	Arginine	9-12	glycogen synthase kinase 3 alpha	Rattus norvegicus	237-247
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	136-144	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-6
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	136-144	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-4
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	168-176	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-6
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	168-176	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-4
25195695-2	2014	Since NO synthase (NOS) and arginase compete for the same substrate l-arginine, limiting arginase activity may provide more NO and thus be a beneficial therapeutic approach to erectile dysfunction (ED).	Arginine	68-78	nitric oxide synthase 1, neuronal	Mus musculus	6-17
23215832-1	2013	Nitric oxide (NO) is produced from the conversion of L-arginine by NO synthase (NOS) and regulates a variety of processes in the gastrointestinal tract.	Arginine	53-63	nitric oxide synthase 1, neuronal	Mus musculus	67-78
23255810-9	2013	We further determined that arginine (R) at position 353 of the PA gene contributes to the high virulence of CK10 in mice.	Arginine	27-35	keratin 10	Mus musculus	108-112
23255810-9	2013	We further determined that arginine (R) at position 353 of the PA gene contributes to the high virulence of CK10 in mice.	Arginine	37-38	keratin 10	Mus musculus	108-112
24107494-3	2013	Breakthroughs in understanding arginine metabolism have led to the identification of myeloid cells that express arginase 1, causing significant depletion of arginine - an essential amino acid for normal T lymphocyte function.	Arginine	31-39	arginase 1	Homo sapiens	112-122
23085017-13	2013	Interleukin-6, tumor necrosis factor-alpha, and NO production in the macrophages decreased and arginase-1 was upregulated in the ARG-treated rats.	Arginine	129-132	arginase 1	Rattus norvegicus	95-105
23085017-15	2013	Arginine improved nitrogen balance and had an anti-inflammatory action on macrophages by regulating NO production, probably through arginase-1 expression.	Arginine	0-8	arginase 1	Rattus norvegicus	132-142
23555788-9	2013	These data suggest that Ps-1 protein facilitates PROP bitter taste perception and identifies a role for free L-Arg and L-Lys in PROP tasting.	Arginine	109-114	taste 2 receptor member 62 pseudogene	Homo sapiens	24-28
23451136-3	2013	However, the mechanism by which PRMT5 utilizes MEP50 to discriminate substrates and to specifically methylate target arginines is unclear.	Arginine	117-126	WD repeat domain 77 S homeolog	Xenopus laevis	47-52
23462742-7	2013	Moreover, the present study identified Arg as a key CaM interacting residue from Nm/Ng.	Arginine	39-42	neurogranin	Homo sapiens	84-86
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Arginine	138-146	Ypq2p	Saccharomyces cerevisiae S288C	93-97
22928666-8	2012	Interestingly, mice that are deficient in Arg-II gene (Arg-II(-/-) ) are not only protected from age-associated increase in Arg-II, VCAM1/ICAM1, aging markers, and eNOS-uncoupling in the aortas but also reveal a decrease in S6K1 activity.	Arginine	42-45	intercellular adhesion molecule 1	Mus musculus	138-143
23399839-6	2012	L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK zeta chain and the NK-92 intracellular production of IFN-gamma.	Arginine	0-5	natural cytotoxicity triggering receptor 1	Homo sapiens	70-75
22971826-3	2012	Resistance to ND18 correlates with an arginine residue at TGB1 position 390 (R(390)) and a threonine at position 392 (T(392)), whereas the virulent NW strain contains lysines (K) at both positions.	Arginine	38-46	pro-platelet basic protein	Homo sapiens	58-62
23105135-4	2012	Additionally, when challenged with mycobacterial agonists, macrophages from TLR1 602S/S individuals resist induction of host arginase-1, an enzyme that depletes cellular arginine stores required for the production of antimicrobial reactive nitrogen intermediates.	Arginine	170-178	arginase 1	Homo sapiens	125-135
22987726-2	2012	NO is synthesized from the amino acid L-arginine by nitric oxide synthases (NOS1, NOS2, and NOS3), which are encoded by separate genes and display different tissue distributions.	Arginine	38-48	nitric oxide synthase 1	Homo sapiens	76-80
22350545-6	2012	The amino acid substitution of a glycine to arginine resulted in a markedly reduced steady-state level of the IVD protein, which explains the nearly complete lack of IVD enzyme activity as assessed in fibroblast homogenates.	Arginine	44-52	isovaleryl-CoA dehydrogenase	Homo sapiens	110-113
22350545-6	2012	The amino acid substitution of a glycine to arginine resulted in a markedly reduced steady-state level of the IVD protein, which explains the nearly complete lack of IVD enzyme activity as assessed in fibroblast homogenates.	Arginine	44-52	isovaleryl-CoA dehydrogenase	Homo sapiens	166-169
23035874-2	2012	MALT1 cleaves protein substrates after a positively charged Arginine residue.	Arginine	60-68	MALT1 paracaspase	Homo sapiens	0-5
22801880-4	2012	All of our patients with BSI or SICI carried at least 1 specific missense mutation in TGM1 concerning an arginine at position 307 or 315.	Arginine	105-113	transglutaminase 1	Homo sapiens	86-90
23060725-5	2012	RESULTS: After exposing the cultured mouse retinal cells to tPA plus L-arginine or L-arginine alone, cyclic-GMP concentrations were 61.9 +- 5.1 pmole/mL and 63.1 +- 6.1 pmole/mL, respectively.	Arginine	69-79	5'-nucleotidase, cytosolic II	Mus musculus	108-111
23060725-5	2012	RESULTS: After exposing the cultured mouse retinal cells to tPA plus L-arginine or L-arginine alone, cyclic-GMP concentrations were 61.9 +- 5.1 pmole/mL and 63.1 +- 6.1 pmole/mL, respectively.	Arginine	83-93	5'-nucleotidase, cytosolic II	Mus musculus	108-111
23060725-10	2012	CONCLUSIONS: L-arginine increases intracellular cyclic-GMP and may give rise to retinal cells through this mechanism.	Arginine	13-23	5'-nucleotidase, cytosolic II	Mus musculus	55-58
22214652-10	2012	The mRNA expression of TLR4, TLR5, Myd88, p65 NF-kappaB and TNF-alpha was up-regulated (P &lt; 0 05) by the S.C500 challenge in different tissues, but was down-regulated (P &lt; 0 05) by Arg supplementation.	Arginine	187-190	toll like receptor 4	Sus scrofa	23-27
21975054-1	2012	Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea.	Arginine	53-61	arginase 1	Rattus norvegicus	0-10
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Arginine	110-118	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22751928-5	2012	We also identified three arginine residues of beta-TrCP that participate in Nrf2 docking.	Arginine	25-33	beta-transducin repeat containing protein	Mus musculus	46-55
22767602-7	2012	The promotion of Tau exon 10 inclusion by SRp55 required the arginine/serine-rich region, which was responsible for the subnucleic speckle localization.	Arginine	61-69	serine and arginine rich splicing factor 6	Homo sapiens	42-47
22787143-0	2012	A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.	Arginine	123-131	solute carrier family 7 member 2	Homo sapiens	90-96
22787143-6	2012	Noticeably, arginine transport by the hCAT-2/SLC7A14 chimera was pH-dependent, trans-stimulated, and inhibited by alpha-trimethyl-L-lysine, properties assigned to lysosomal transport system c in human skin fibroblasts.	Arginine	12-20	solute carrier family 7 member 2	Homo sapiens	38-44
22822061-6	2012	Single- or multiple-site mutants at five positively charged residues of LRR11 (LRR11m1-9), especially Arg-337 and Lys-367, were shown to contribute to hTLR9 binding of CpG ODN.	Arginine	102-105	toll like receptor 9	Homo sapiens	151-156
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Arginine	65-68	toll like receptor 9	Homo sapiens	20-25
22822061-8	2012	Prediction of whole hTLR9 ECD-CpG ODN interactions revealed that Arg-337 and Lys-338 directly contact CpG ODN through hydrogen bonding, whereas Lys-347, Arg-348, and His-353 contribute to stabilizing the shape of the ligand binding region.	Arginine	153-156	toll like receptor 9	Homo sapiens	20-25
23030042-1	2013	Nitric oxide synthase (NOS) converts l-arginine into l-citrulline and releases the important signaling molecule nitric oxide (NO).	Arginine	37-47	nitric oxide synthase 1	Homo sapiens	0-21
22552935-3	2012	Arginine transport by cationic amino acid transporter-1 (CAT-1), which governs endothelial NO generation, is reduced in both renal failure and pregnancy.	Arginine	0-8	solute carrier family 7 member 1	Rattus norvegicus	22-55
24385142-1	2014	L-citrulline (Cit) is a co-product of NO synthesis and a direct L-arginine (Arg) precursor for de novo NO synthesis.	Arginine	64-74	citron rho-interacting serine/threonine kinase	Rattus norvegicus	14-17
22552935-3	2012	Arginine transport by cationic amino acid transporter-1 (CAT-1), which governs endothelial NO generation, is reduced in both renal failure and pregnancy.	Arginine	0-8	solute carrier family 7 member 1	Rattus norvegicus	57-62
22552935-10	2012	These studies suggest that in CRF rats, pregnancy induces a profound decrease in glomerular arginine transport, through posttranslational regulation of CAT-1 by PKC-alpha, resulting in attenuated NO generation.	Arginine	92-100	solute carrier family 7 member 1	Rattus norvegicus	152-157
22587366-5	2012	Using a three-dimensional model of Pho84 created on the basis of the GlpT permease, complemented with multiple sequence alignments, we selected Arg(168) and Lys(492), and Asp(178), Asp(358) and Glu(473) as residues potentially involved in phosphate or proton binding respectively, during transport.	Arginine	144-147	phosphate transporter PHO84	Saccharomyces cerevisiae S288C	35-40
23281927-4	2013	Modeling showed more arginine-arene interactions for galectin-3 than for galectin-1.	Arginine	21-29	galectin 3	Homo sapiens	53-63
23806011-2	2013	In the first case, a new delta-globin variant, Hb A2-Pierre-Benite [delta83(EF7)Gly Arg; HBD: c.250G&gt;C] is associated with Hb Groene Hart [alpha119(H2)Pro Ser (alpha1); HBA1: c.358C&gt;T], an alpha-thalassemic variant.	Arginine	84-87	hemoglobin subunit alpha 2	Homo sapiens	47-52
23806011-2	2013	In the first case, a new delta-globin variant, Hb A2-Pierre-Benite [delta83(EF7)Gly Arg; HBD: c.250G&gt;C] is associated with Hb Groene Hart [alpha119(H2)Pro Ser (alpha1); HBA1: c.358C&gt;T], an alpha-thalassemic variant.	Arginine	84-87	hemoglobin subunit alpha 1	Homo sapiens	172-176
23806116-0	2013	Hb Papanui [alpha99(G8)Lys Arg; HBA2: c.299A&gt;G]: a novel silent substitution interfering in Hb A1c determination.	Arginine	27-30	hemoglobin subunit alpha 2	Homo sapiens	32-36
23806116-1	2013	We report a novel hemoglobin (Hb) mutation [Hb Papanui [alpha99(G8)Lys Arg; HBA2: c.299A&gt;G] that was identified in an individual with an inappropriately low Hb A1c value of 2.8% when using an ion exchange method.	Arginine	71-74	hemoglobin subunit alpha 2	Homo sapiens	76-80
24385142-1	2014	L-citrulline (Cit) is a co-product of NO synthesis and a direct L-arginine (Arg) precursor for de novo NO synthesis.	Arginine	76-79	citron rho-interacting serine/threonine kinase	Rattus norvegicus	14-17
24385142-5	2014	Cit uptake was not affected by Arg, the y(+)/y(+)L transport system substrate, nor by amino acids taken up by systems A, xc (-)or XAG.	Arginine	31-34	citron rho-interacting serine/threonine kinase	Rattus norvegicus	0-3
22817743-1	2012	SRPK1 (serine-arginine protein kinase 1) is a protein kinase that specifically phosphorylates proteins containing serine-arginine-rich domains.	Arginine	14-22	SRSF protein kinase 1	Homo sapiens	0-5
24385142-8	2014	The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively.	Arginine	140-143	citron rho-interacting serine/threonine kinase	Rattus norvegicus	103-106
25443724-7	2014	Kidney COX-2 level was only different in the l-arginine-treated group 48h after reperfusion compared to the IRI group.	Arginine	45-55	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	7-12
22684005-3	2012	RFamide peptides, members of peptides possessing an Arg-Phe-NH(2) motif at their C-terminus, have recently been characterized as major regulators of GnRH neurons.	Arginine	52-55	gonadotropin releasing hormone 1	Homo sapiens	149-153
24282631-4	2013	The aim of this study is to see if oxy- and sulfoanalogues of arginine can be recognized by human arginyl-tRNA synthetase (HArgS)-an enzyme responsible for coupling of L-arginine with its cognate tRNA in a two-step catalytic reaction.	Arginine	62-70	arginyl-tRNA synthetase 1	Homo sapiens	98-121
24282631-4	2013	The aim of this study is to see if oxy- and sulfoanalogues of arginine can be recognized by human arginyl-tRNA synthetase (HArgS)-an enzyme responsible for coupling of L-arginine with its cognate tRNA in a two-step catalytic reaction.	Arginine	168-178	arginyl-tRNA synthetase 1	Homo sapiens	98-121
23179835-9	2013	M2 macrophages constitutively produce the enzyme arginase I (argI), which sequesters L-arginine from iNOS and results in the production of ornithine and downstream polyamines and L-proline.	Arginine	85-95	arginase, liver	Mus musculus	49-59
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	214-222	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	161-165
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	227-230	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	161-165
25404067-1	2014	Using the chain-build-up method based on Empirical Conformational Energies of Peptides Program including solvation, we have computed, the low energy conformations of gonadotrpin-releasing hormone, GnRH, whose sequence is Pyro-Glu(PG)-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.	Arginine	258-261	gonadotropin releasing hormone 1	Homo sapiens	197-201
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	93-96	plasminogen	Homo sapiens	31-38
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	93-96	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	148-152
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	101-104	plasminogen	Homo sapiens	31-38
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	101-104	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	148-152
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	83-86	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	28-32
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	83-86	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	109-113
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	91-94	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	28-32
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	91-94	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	109-113
22610100-10	2012	Heterologous expression of NR2B with Gln(29)-Arg(67) deleted is functional but exhibits reduced ifenprodil inhibition and increased glycine EC(50) with no change in glutamate EC(50).	Arginine	45-48	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	27-31
24367270-4	2013	We had shown that mutation of arginines R36 and R42 in the F plasmid CBP, SopB, reduces stimulation of SopA-catalyzed ATP hydrolysis without changing SopA-SopB affinity, suggesting the role of hydrolysis could be analyzed using SopA with normal conformational responses to ATP.	Arginine	30-39	ATPase phospholipid transporting 8A2	Homo sapiens	118-121
24367270-4	2013	We had shown that mutation of arginines R36 and R42 in the F plasmid CBP, SopB, reduces stimulation of SopA-catalyzed ATP hydrolysis without changing SopA-SopB affinity, suggesting the role of hydrolysis could be analyzed using SopA with normal conformational responses to ATP.	Arginine	30-39	ATPase phospholipid transporting 8A2	Homo sapiens	273-276
23349763-2	2013	Agmatine (Agm), a guanidinium compound formed from decarboxylation of L-arginine by arginine decarboxylase, is a neurotransmitter/neuromodulator and been reported to exert neuroprotective effects in central nervous system injury models including SCI.	Arginine	70-80	antizyme inhibitor 2	Mus musculus	84-106
25352667-7	2014	Because this invariant Arg is strictly required to stimulate Torsin ATPase activity but is dispensable for Torsin binding, we propose that LAP1 and LULL1 regulate Torsin ATPase activity through an active site complementation mechanism.	Arginine	23-26	torsin 1A interacting protein 2	Homo sapiens	148-153
23249737-4	2012	A tandem plant homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 Arg 3 (H4R3me0 or H4R3me2a) and is required for MLL4"s nucleosomal methyltransferase activity and MLL4-mediated differentiation.	Arginine	112-115	lysine methyltransferase 2B	Homo sapiens	41-45
23249737-4	2012	A tandem plant homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 Arg 3 (H4R3me0 or H4R3me2a) and is required for MLL4"s nucleosomal methyltransferase activity and MLL4-mediated differentiation.	Arginine	112-115	lysine methyltransferase 2B	Homo sapiens	160-164
23249737-4	2012	A tandem plant homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 Arg 3 (H4R3me0 or H4R3me2a) and is required for MLL4"s nucleosomal methyltransferase activity and MLL4-mediated differentiation.	Arginine	112-115	lysine methyltransferase 2B	Homo sapiens	160-164
22810897-3	2012	Our data demonstrated that Abl and Arg were activated downstream of chemokine receptors and mediated the chemokine-induced tyrosine phosphorylation of human enhancer of filamentation 1 (HEF1), an adaptor protein that is required for the activity of the guanosine triphosphatase Rap1, which mediates cell adhesion and migration.	Arginine	35-38	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	157-184
22810897-3	2012	Our data demonstrated that Abl and Arg were activated downstream of chemokine receptors and mediated the chemokine-induced tyrosine phosphorylation of human enhancer of filamentation 1 (HEF1), an adaptor protein that is required for the activity of the guanosine triphosphatase Rap1, which mediates cell adhesion and migration.	Arginine	35-38	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	186-190
22637474-0	2012	Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove.	Arginine	69-72	prostaglandin-endoperoxide synthase 2	Mus musculus	39-55
22637474-4	2012	Mutational analyses have established that an interaction of the carboxylate of AA with Arg-120 is required for high affinity binding by COX-1 but not COX-2, suggesting that hydrophobic interactions between the omega-end of substrates and cyclooxygenase channel residues play a significant role in COX-2-mediated oxygenation.	Arginine	87-90	cytochrome c oxidase II, mitochondrial	Mus musculus	297-302
22637474-5	2012	We used structure-function analyses to investigate the role that Arg-120 and residues lining the hydrophobic groove play in the binding and oxygenation of substrates by murine (mu) COX-2.	Arginine	65-68	cytochrome c oxidase II, mitochondrial	Mus musculus	181-186
22637474-9	2012	Overall, these findings implicate Arg-120 and hydrophobic groove residues as determinants that govern proper alignment of the bisallylic carbon below Tyr-385 for catalysis in COX-2 and confirm nuances between COX isoforms that explain substrate promiscuity.	Arginine	34-37	cytochrome c oxidase II, mitochondrial	Mus musculus	175-180
25383878-5	2014	The mutation affects a highly conserved arginine residue that is crucial for PRPF4 function.	Arginine	40-48	pre-mRNA processing factor 4	Homo sapiens	77-82
22443861-1	2012	BACKGROUND INFORMATION: The arginine-type soluble N-ethylmaleimide-sensitive factor attachment protein receptor (R-SNARE) ykt6 possesses several atypical properties including selective high expression in neurons, a lipidated C-terminus, localization to punctae that do not correspond with known endomembrane markers, a potent ability to protect the secretory pathway from alpha-synuclein over-expression and specific up-regulation in tumors.	Arginine	28-36	YKT6 v-SNARE homolog	Rattus norvegicus	122-126
22628489-3	2012	Among them, a functional FCGR2A polymorphism leading to amino acid change of histidine (H) to arginine (R) at position 131 appears to be a major candidate in adult invasive pneumococcal diseases (IPDs).	Arginine	94-102	Fc gamma receptor IIa	Homo sapiens	25-31
23032699-6	2012	Furthermore, co-immunoprecipitation assays suggested that decrease of p16 arginine methylation level promoted the association of p16 with CDK4.	Arginine	74-82	cyclin dependent kinase 4	Homo sapiens	138-142
22472948-3	2012	Here, we show the application of an arginine-grafted bioreducible poly(disulfide amine) (ABP) polymer gene delivery system as a platform for in vivo transfer of human erythropoietin plasmid DNA (phEPO) to produce long-term, therapeutic erythropoiesis.	Arginine	36-44	amine oxidase copper containing 1	Homo sapiens	89-92
25172766-7	2014	Simultaneous substitution of arginine for the three lysines fully prevented Ptr2 degradation.	Arginine	29-37	Ptr2p	Saccharomyces cerevisiae S288C	76-80
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Arginine	10-18	lysine acetyltransferase 8	Homo sapiens	58-62
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Arginine	10-18	lysine acetyltransferase 8	Homo sapiens	139-143
23194061-2	2012	Previously, we found that human sperm tails contain trophinin, bystin and tastin proteins, and that trophinin-binding GWRQ (glycine, tryptophan, arginine, glutamine) peptide enhanced motility of human sperm.	Arginine	145-153	bystin like	Homo sapiens	63-69
23194061-2	2012	Previously, we found that human sperm tails contain trophinin, bystin and tastin proteins, and that trophinin-binding GWRQ (glycine, tryptophan, arginine, glutamine) peptide enhanced motility of human sperm.	Arginine	145-153	trophinin	Mus musculus	100-109
25142587-2	2014	We show here for the first time that the interaction between HPV1 E1^E4 and SRPK1 leads to potent inhibition of SRPK1 phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism, including pre-mRNA processing, mRNA export, and translation.	Arginine	149-157	SRSF protein kinase 1	Homo sapiens	76-81
23043141-7	2012	Mutation of Arg(582) in yeast Sdh1 precludes flavinylation as well as assembly of the tetrameric enzyme complex.	Arginine	12-15	succinate dehydrogenase flavoprotein subunit SDH1	Saccharomyces cerevisiae S288C	30-34
23043141-9	2012	Mutations of either Arg(582) or Arg(638)/Cys(630) do not markedly destabilize the Sdh1 polypeptide; however, the steady-state level of Sdh5 is markedly attenuated in the Sdh1 mutant cells.	Arginine	20-23	succinate dehydrogenase complex assembly factor 2	Homo sapiens	135-139
23043141-12	2012	The Arg residues may be important not only for Sdh5 association but also in the recruitment and/or guidance of FAD and or succinate to the substrate site for the flavinylation reaction.	Arginine	4-7	succinate dehydrogenase complex assembly factor 2	Homo sapiens	47-51
22546681-1	2012	Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP.	Arginine	0-8	amine oxidase copper containing 1	Homo sapiens	54-57
22546681-1	2012	Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP.	Arginine	0-8	amine oxidase copper containing 1	Homo sapiens	182-185
22546681-1	2012	Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP.	Arginine	0-8	amine oxidase copper containing 1	Homo sapiens	182-185
22971346-1	2012	A gly(388)arg polymorphism (rs351855) in the transmembrane domain of the fibroblast growth factor receptor (FGFR4) is associated with increased risk, staging, and metastasis in several different types of cancer.	Arginine	10-13	fibroblast growth factor receptor 4	Homo sapiens	108-113
25142587-2	2014	We show here for the first time that the interaction between HPV1 E1^E4 and SRPK1 leads to potent inhibition of SRPK1 phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism, including pre-mRNA processing, mRNA export, and translation.	Arginine	149-157	SRSF protein kinase 1	Homo sapiens	112-117
22609403-4	2012	We found that 21.5-kDa MBP contains two non-traditional PY-nuclear-localization signals, and that arginine and lysine residues within these motifs were involved in subcellular trafficking of this protein to the nucleus, where it may have functional roles during myelinogenesis.	Arginine	98-106	myelin basic protein	Homo sapiens	23-26
25278557-2	2014	A variant in the Ring Finger 213 gene (RNF213), altering arginine at position 4810 (p.R4810K), is associated with MMD in Asian populations.	Arginine	57-65	ring finger protein 213	Homo sapiens	39-45
25386179-4	2014	Among other markers, inducible nitric oxide synthase and type-I arginase (Arg-I), the enzymes that are involved in l-arginine/nitric oxide (NO) metabolism, are associated with the M1 and M2 phenotype, respectively, and therefore widely used as the markers for characterization of the two macrophage phenotypes.	Arginine	115-125	arginase 1	Homo sapiens	57-72
22713343-4	2012	To better understand the critical functions of this domain, we generated recombinant WRN proteins (using a novel purification scheme) with mutations in Arg-993 within the alpha2-alpha3 loop of the RQC domain and in Phe-1037 of the  -wing motif.	Arginine	152-155	WRN RecQ like helicase	Homo sapiens	85-88
22713343-9	2012	Thus, the Arg-993 and Phe-1037 in the RQC domain play essential roles in catalytic activity, and in functional interactions mediated by WRN.	Arginine	10-13	WRN RecQ like helicase	Homo sapiens	136-139
22986737-3	2012	This study examined the predictive and prognostic value of a single nucleotide polymorphism substituting an arginine (R) for glycine (G) in codon 388 of the FGFR4 transmembrane domain.	Arginine	108-116	fibroblast growth factor receptor 4	Homo sapiens	157-162
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Arginine	174-182	karyopherin beta	Saccharomyces cerevisiae S288C	71-76
25333616-5	2014	We found that leucine, tyrosine, arginine, homoarginine or glucose treatment of the GA1 model cells reduced the gene expression of caspase-3, caspase-8, caspase-9, bax, fos, and jun and restored the intracellular NADH and ATP levels.	Arginine	33-41	caspase 9	Mus musculus	153-162
24355598-1	2014	TAR DNA-binding protein (TDP-43) pathology and reduced expression of adenosine deaminase acting on RNA 2 (ADAR2), which is the RNA editing enzyme responsible for adenosine-to-inosine conversion at the GluA2 glutamine/arginine (Q/R) site, concomitantly occur in the same motor neurons of amyotrophic lateral sclerosis (ALS) patients; this finding suggests a link between these two ALS-specific molecular abnormalities.	Arginine	217-225	adenosine deaminase RNA specific B1	Homo sapiens	69-104
22977242-2	2012	Previous studies have demonstrated the importance of Arg-266, a residue at the heme pocket end of alpha-helix 8, for communication between the heme and PLP sites.	Arginine	53-56	pyridoxal phosphatase	Homo sapiens	152-155
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	29-35
22560905-2	2012	The integrins recognize a short tripeptide motif of arg-lys-cys (RKC) in CD23, and peptides containing this motif inhibit the binding of CD23 to B cells and monocytes; neither fibronectin, nor vitronectin, which contain arg-gly-asp motifs, inhibit binding of RKC-containing peptides to cells.	Arginine	52-55	Fc epsilon receptor II	Homo sapiens	73-77
22560905-2	2012	The integrins recognize a short tripeptide motif of arg-lys-cys (RKC) in CD23, and peptides containing this motif inhibit the binding of CD23 to B cells and monocytes; neither fibronectin, nor vitronectin, which contain arg-gly-asp motifs, inhibit binding of RKC-containing peptides to cells.	Arginine	220-223	Fc epsilon receptor II	Homo sapiens	137-141
24355598-1	2014	TAR DNA-binding protein (TDP-43) pathology and reduced expression of adenosine deaminase acting on RNA 2 (ADAR2), which is the RNA editing enzyme responsible for adenosine-to-inosine conversion at the GluA2 glutamine/arginine (Q/R) site, concomitantly occur in the same motor neurons of amyotrophic lateral sclerosis (ALS) patients; this finding suggests a link between these two ALS-specific molecular abnormalities.	Arginine	217-225	adenosine deaminase RNA specific B1	Homo sapiens	106-111
22447650-10	2012	Moreover, the variability of the angle between each Rev monomer as measured during the MD simulations suggests a role of the Rev protein in allowing flexibility of the arginine rich domain (ARM) to accommodate RNA binding.	Arginine	168-176	Rev	Human immunodeficiency virus 1	52-55
22447650-10	2012	Moreover, the variability of the angle between each Rev monomer as measured during the MD simulations suggests a role of the Rev protein in allowing flexibility of the arginine rich domain (ARM) to accommodate RNA binding.	Arginine	168-176	Rev	Human immunodeficiency virus 1	125-128
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Arginine	70-73	islet amyloid polypeptide	Homo sapiens	30-34
25219497-1	2014	The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development.	Arginine	39-42	serine/arginine repetitive matrix 4	Homo sapiens	64-70
22898766-6	2012	RESULTS: Neprilysin prevented IAPP fibrillisation by cleaving IAPP at Arg(11)-Leu(12), Leu(12)-Ala(13), Asn(14)-Phe(15), Phe(15)-Leu(16), Asn(22)-Phe(23) and Ala(25)-Ile(26).	Arginine	70-73	islet amyloid polypeptide	Homo sapiens	62-66
22902629-4	2012	To investigate the role of these contacts in reactions involving circular clamps, we examined single arginine/lysine mutants of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clamp onto primer template DNA (ptDNA).	Arginine	101-109	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	153-187
22411759-1	2012	BACKGROUND: The hemolytic products cell-free oxyhemoglobin (FHb) and arginase-1 reduce nitric oxide (NO) bioavailability by scavenging NO and by degrading the NO precursor arginine to ornithine, respectively.	Arginine	172-180	arginase 1	Homo sapiens	69-79
25219497-1	2014	The vertebrate and neural-specific Ser/Arg (SR)-related protein nSR100/SRRM4 regulates an extensive program of alternative splicing with critical roles in nervous system development.	Arginine	39-42	serine/arginine repetitive matrix 4	Homo sapiens	71-76
22902629-4	2012	To investigate the role of these contacts in reactions involving circular clamps, we examined single arginine/lysine mutants of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) in replication factor C (RFC)-catalyzed loading of the clamp onto primer template DNA (ptDNA).	Arginine	101-109	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	189-193
25117899-4	2014	We used the H2CN NMR pulse sequence to detect heparin binding through the side-chain resonances Hepsilon-Cepsilon-Nzeta of Lys and Hdelta-Cdelta-Nepsilon of Arg in the two proteins of hepatoma-derived growth factor (HDGF) and basic fibroblast growth factor (FGF2).	Arginine	157-160	heparin binding growth factor	Homo sapiens	184-214
22976420-9	2012	Furthermore, Th2 cytokines increase the expression of arginase-1 (ARG1) in myeloid-derived suppressor cells (MDSC"s) causing an arginine deficient state, which further impairs lymphocyte function.	Arginine	128-136	arginase 1	Homo sapiens	54-64
22976420-9	2012	Furthermore, Th2 cytokines increase the expression of arginase-1 (ARG1) in myeloid-derived suppressor cells (MDSC"s) causing an arginine deficient state, which further impairs lymphocyte function.	Arginine	128-136	arginase 1	Homo sapiens	66-70
22214652-11	2012	In conclusion, Arg supplementation could inhibit the excessive activation of the TLR4-Myd88 signalling pathway and thus attenuated the negative effects caused by the immune challenge of S.C500.	Arginine	15-18	toll like receptor 4	Sus scrofa	81-85
22214652-11	2012	In conclusion, Arg supplementation could inhibit the excessive activation of the TLR4-Myd88 signalling pathway and thus attenuated the negative effects caused by the immune challenge of S.C500.	Arginine	15-18	MYD88 innate immune signal transduction adaptor	Sus scrofa	86-91
22357953-0	2012	Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.	Arginine	56-64	Wnt family member 3A	Homo sapiens	0-5
22357953-3	2012	We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation.	Arginine	27-35	Wnt family member 3A	Homo sapiens	62-67
22357953-6	2012	Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive "switch" regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling.	Arginine	0-8	Wnt family member 3A	Homo sapiens	46-51
22357953-6	2012	Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive "switch" regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling.	Arginine	0-8	Wnt family member 3A	Homo sapiens	46-49
22452443-2	2012	The RGD motif {cyclic(Arg-Gly-Asp-D-Tyr-Asp)} was coupled to [Cys(3,4,10), D-Phe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} through a neutral glycine linker to eliminate the positively charged amino side chain of the Lys linker or without a linker to delete the Lys linker.	Arginine	22-25	pro-opiomelanocortin-alpha	Mus musculus	93-102
22452443-2	2012	The RGD motif {cyclic(Arg-Gly-Asp-D-Tyr-Asp)} was coupled to [Cys(3,4,10), D-Phe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} through a neutral glycine linker to eliminate the positively charged amino side chain of the Lys linker or without a linker to delete the Lys linker.	Arginine	85-88	pro-opiomelanocortin-alpha	Mus musculus	93-102
25117899-4	2014	We used the H2CN NMR pulse sequence to detect heparin binding through the side-chain resonances Hepsilon-Cepsilon-Nzeta of Lys and Hdelta-Cdelta-Nepsilon of Arg in the two proteins of hepatoma-derived growth factor (HDGF) and basic fibroblast growth factor (FGF2).	Arginine	157-160	heparin binding growth factor	Homo sapiens	216-220
25345946-0	2014	[Correlation of polymorphisms of adiponectin receptor 2 gene +33371Gln/Arg, cytochrome P4502E1 gene Rsa I and smoking with nonalcoholic fatty liver disease].	Arginine	71-74	adiponectin receptor 2	Homo sapiens	33-55
22411993-2	2012	FXa also cleaves FVIII/FVIIIa at Arg(336) and Arg(562) resulting in inactivation of the cofactor.	Arginine	33-36	coagulation factor VIII	Homo sapiens	17-22
22411993-8	2012	The capacity for FXa to activate FVIII variants where cleavage at Arg(336) was accelerated due to flanking sequence replacement showed marked reductions in peak activity, whereas reducing the cleavage rate at this site enhanced peak activity.	Arginine	66-69	coagulation factor VIII	Homo sapiens	33-38
25139236-6	2014	Interestingly, cIAP1 was capable of ubiquitinating EndoG in the presence of wild-type and mutant Ubiquitin, in which all lysines except K63 were mutated to arginine.	Arginine	156-164	baculoviral IAP repeat containing 2	Homo sapiens	15-20
22541557-1	2012	Argininosuccinate lyase (ASL) is required for the synthesis and channeling of L-arginine to nitric oxide synthase (NOS) for nitric oxide (NO) production.	Arginine	78-88	nitric oxide synthase 1, neuronal	Mus musculus	92-113
22827639-1	2012	Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers.	Arginine	156-164	carboxypeptidase B2	Homo sapiens	0-43
22827639-1	2012	Thrombin activatable fibrinolysis inhibitor (TAFI) is a zymogene that potently inhibits fibrinolysis through the removal of the carboxy-terminal lysine and arginine residues from partially degraded fibrin polymers.	Arginine	156-164	carboxypeptidase B2	Homo sapiens	45-49
25103078-10	2014	Furthermore, a significant synergistic effect in an additive model (OR = 3.5) between the GSTO1 Ala/Ala genotype and the SULT1A1 Arg/Arg genotype on UCB risk was observed.	Arginine	129-132	sulfotransferase family 1A member 1	Homo sapiens	121-128
22416259-2	2012	This Th2 cytokine induces Arg1 activity, which converts arginine into ornithine, and ornithine can be decarboxylated by ODC to produce putrescine, which is further converted into spermidine and spermine.	Arginine	56-64	arginase 1	Homo sapiens	26-30
25103078-10	2014	Furthermore, a significant synergistic effect in an additive model (OR = 3.5) between the GSTO1 Ala/Ala genotype and the SULT1A1 Arg/Arg genotype on UCB risk was observed.	Arginine	133-136	sulfotransferase family 1A member 1	Homo sapiens	121-128
25012667-4	2014	Importantly, this interaction leads to the arginine methylation of GATA4 at positions of 229, 265, and 317, which leads to an inhibition of the GATA4 transcriptional activity, predominantly through blocking the p300-mediated acetylation of GATA4 in cardiomyocytes.	Arginine	43-51	E1A binding protein p300	Homo sapiens	211-215
22474388-0	2012	NSP4, an elastase-related protease in human neutrophils with arginine specificity.	Arginine	61-69	serine protease 57	Homo sapiens	0-4
22474388-3	2012	Here, we report on the identification of a fourth serine protease (NSP4) with 39% identity to NE and PR3, but arginine specificity, yet sharing features like propeptide processing by dipeptidyl peptidase I, storage, and release as an active enzyme with the three active proteases.	Arginine	110-118	serine protease 57	Homo sapiens	67-71
22761421-2	2012	In this report, we show that PRMT7 interacts with the BRG1-based hSWI/SNF chromatin remodeling complex and specifically methylates histone H2A Arg-3 (H2AR3) and histone H4 Arg-3 (H4R3).	Arginine	143-146	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	54-58
22761421-2	2012	In this report, we show that PRMT7 interacts with the BRG1-based hSWI/SNF chromatin remodeling complex and specifically methylates histone H2A Arg-3 (H2AR3) and histone H4 Arg-3 (H4R3).	Arginine	172-175	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Mus musculus	54-58
22710435-5	2012	Mass spectrometry results showed a complex pattern of MnSOD-methylation at both lysine (68, 89, 122, and 202) and arginine (197 and 216) residues.	Arginine	114-122	superoxide dismutase 2	Homo sapiens	54-59
25148519-10	2014	The two sites within proSAAS that are known to be efficiently cleaved by furin were altered by site-directed mutagenesis to convert the P4 Arg into Lys; this change converts the sequences from furin consensus sites into prohormone convertase consensus sites.	Arginine	139-142	furin (paired basic amino acid cleaving enzyme)	Mus musculus	73-78
22710435-7	2012	Computational-based simulations indicate that lysine and arginine methylation of MnSOD during quiescence would allow greater accessibility to the enzyme active site as well as increase the positive electrostatic potential around and within the active site.	Arginine	57-65	superoxide dismutase 2	Homo sapiens	81-86
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	154-162	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	4-9
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	154-162	adenosine deaminase RNA specific B1	Homo sapiens	51-56
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	154-162	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	127-132
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	164-167	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	4-9
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	164-167	adenosine deaminase RNA specific B1	Homo sapiens	51-56
22514516-2	2012	The GluA2 subunit is subject to RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Gln; Q), present in the GluA2 gene, to a codon for arginine (Arg; R) found in the mRNA.	Arginine	164-167	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	127-132
22508683-4	2012	The CCS mutation, p.Arg163Trp, predicts substitution of a highly conserved arginine residue at position 163, with tryptophan in domain II of CCS, which interacts directly with superoxide dismutase 1 (SOD1).	Arginine	75-83	copper chaperone for superoxide dismutase	Homo sapiens	4-7
22508683-4	2012	The CCS mutation, p.Arg163Trp, predicts substitution of a highly conserved arginine residue at position 163, with tryptophan in domain II of CCS, which interacts directly with superoxide dismutase 1 (SOD1).	Arginine	75-83	copper chaperone for superoxide dismutase	Homo sapiens	141-144
25009204-1	2014	Arginine, a semiessential amino acid implicated in diverse cellular processes, is a substrate for two arginases-Arg1 and Arg2-having different expression patterns and functions.	Arginine	0-8	arginase, liver	Mus musculus	112-116
22327218-0	2012	Arginine methylation controls growth regulation by E2F-1.	Arginine	0-8	E2F transcription factor 1 L homeolog	Xenopus laevis	51-56
22327218-4	2012	We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine methylation is responsible for regulating its biochemical and functional properties, which impacts on E2F-1-dependent growth control.	Arginine	65-73	E2F transcription factor 1 L homeolog	Xenopus laevis	18-23
22327218-6	2012	Arginine methylation influences E2F-1 protein stability, and the enhanced transcription of a variety of downstream target genes reflects increased E2F-1 DNA-binding activity.	Arginine	0-8	E2F transcription factor 1 L homeolog	Xenopus laevis	32-37
22327218-9	2012	Our results establish that arginine methylation regulates the biological activity of E2F-1 activity, and raise the possibility that arginine methylation contributes to tumourigenesis by influencing the E2F pathway.	Arginine	27-35	E2F transcription factor 1 L homeolog	Xenopus laevis	85-90
22775217-5	2012	Activation of AQP4, p66Shc, ATF-6, NADPH oxidase subunits p22phox, gp91phox and matrix metalloproteinase 2 (P &lt; 0.01) was significant and was suppressed by arginine, rhein and indometacin but not by l-arginine.	Arginine	159-167	matrix metallopeptidase 2	Rattus norvegicus	80-106
25009204-10	2014	These results indicate that miR155-induced repression of Arg2 expression is critical for the ability of DCs to drive T cell activation by controlling arginine availability in the extracellular environment.	Arginine	150-158	microRNA 155	Mus musculus	28-34
22775217-5	2012	Activation of AQP4, p66Shc, ATF-6, NADPH oxidase subunits p22phox, gp91phox and matrix metalloproteinase 2 (P &lt; 0.01) was significant and was suppressed by arginine, rhein and indometacin but not by l-arginine.	Arginine	202-212	matrix metallopeptidase 2	Rattus norvegicus	80-106
25043022-3	2014	Using array-based genotyping and exome sequencing, we discovered a nonsense p.Arg684Ter variant (in which arginine is replaced by a termination codon) in the gene TBC1D4 with an allele frequency of 17%.	Arginine	106-114	TBC1 domain family member 4	Homo sapiens	163-169
22547391-7	2012	A p27 mutant in which K100 was substituted by arginine (p27-K100R) cannot be acetylated by PCAF and has a half-life much higher than that of p27WT.	Arginine	46-54	lysine acetyltransferase 2B	Homo sapiens	91-95
22309193-5	2012	By using positional-scanning peptidyl substrate libraries we demonstrate that the activity and specificity of full-length MALT1 is recapitulated by the catalytic domain alone, showing a stringent requirement for cleaving after arginine, and with striking peptide length constraints for efficient hydrolysis.	Arginine	227-235	MALT1 paracaspase	Homo sapiens	122-127
25111602-5	2014	METHODS AND RESULTS: In mitochondria isolated from failing hearts (sheep rapid pacing model and mouse Mst1 transgenic model) we demonstrated a marked reduction in L-arginine uptake (p&lt;0.05 and p&lt;0.01 respectively) and expression of the principal L-arginine transporter, CAT-1 (p&lt;0.001, p&lt;0.01) compared to controls.	Arginine	163-173	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	276-281
22751357-3	2012	RRC1 has a C-terminal arginine/serine-rich (RS) domain that is generally important for the regulation of alternative splicing.	Arginine	22-30	RNA recognition motif (RRM)-containing protein	Arabidopsis thaliana	0-4
24894645-2	2014	The arginine grafted bio-reducible poly (cystamine bisacrylamide-diaminohexane, CBA-DAH) polymer (ABP) conjugated poly (amido amine) (PAMAM), PAM-ABP (PA) was designed previously as an efficient gene delivery carrier.	Arginine	4-12	amine oxidase copper containing 1	Homo sapiens	146-149
24997121-6	2014	Arginine-18 (R18) in H1, and R132 and R143 in H7 were found to be the key players of the Ank(GAG)1D4-NTD(CA) interaction.	Arginine	0-8	fuzzy planar cell polarity protein	Homo sapiens	101-104
25014230-3	2014	In addition, expression of arginase 1 (Arg1) that depletes microenvironment of arginine, an essential aminoacid for T cell function, resulted in an increase in patients at diagnosis.	Arginine	79-87	arginase 1	Homo sapiens	27-37
25014230-3	2014	In addition, expression of arginase 1 (Arg1) that depletes microenvironment of arginine, an essential aminoacid for T cell function, resulted in an increase in patients at diagnosis.	Arginine	79-87	arginase 1	Homo sapiens	39-43
24859084-1	2014	Arginyl-tRNA synthetase (ArgRS) is a tRNA-binding protein that catalyzes the esterification of L-arginine to its cognate tRNA.	Arginine	95-105	arginyl-tRNA synthetase 1	Homo sapiens	0-23
24859084-1	2014	Arginyl-tRNA synthetase (ArgRS) is a tRNA-binding protein that catalyzes the esterification of L-arginine to its cognate tRNA.	Arginine	95-105	arginyl-tRNA synthetase 1	Homo sapiens	25-30
24859084-3	2014	Here, we determined the crystal structures of the apo, L-arginine-complexed, and L-canavanine-complexed forms of the cytoplasmic free isoform of human ArgRS (hArgRS).	Arginine	55-65	arginyl-tRNA synthetase 1	Homo sapiens	151-156
24723222-4	2014	In principal, we generated Knickkopf versions with exchanged residues tryptophan(299), methionine(333), arginine(401), or histidine(437), and scored for the ability of the respective engineered protein to normalize the knickkopf mutant phenotype.	Arginine	104-112	knickkopf	Drosophila melanogaster	27-36
24723222-6	2014	In contrast, arginine(401) is required for full efficiency of Knickkopf activity.	Arginine	13-21	knickkopf	Drosophila melanogaster	62-71
24670969-7	2014	Finally, arginine supplementation reduced (P &lt; 0.05) expression of the proteins for NF-kappaB, MAPK, and PI3K-Akt signaling pathways but activated (P &lt; 0.05) p38 and c-Jun N-terminal protein kinase in the jejunum and the ileum, respectively.	Arginine	9-17	mitogen-activated protein kinase 14	Mus musculus	164-167
24670969-7	2014	Finally, arginine supplementation reduced (P &lt; 0.05) expression of the proteins for NF-kappaB, MAPK, and PI3K-Akt signaling pathways but activated (P &lt; 0.05) p38 and c-Jun N-terminal protein kinase in the jejunum and the ileum, respectively.	Arginine	9-17	jun proto-oncogene	Mus musculus	172-177
24742677-10	2014	An arginine stimulation test and a glucagon challenge confirmed both increases in glucagon secretion and liver glucagon sensitivity in GPR120 KO mice relative to WT mice.	Arginine	3-11	free fatty acid receptor 4	Mus musculus	135-141
24650999-11	2014	RESULTS: Based on high performance gel permeation chromatography (HPGPC), Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) analyses, the isolated protein (PEP) had a molecular weight of 63 kDa, a secondary (alpha-helical) structure and was mainly composed of arginine, serine and glycine.	Arginine	282-290	prolyl endopeptidase	Homo sapiens	178-181
22718948-2	2012	Previous studies in cell culture have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich (SR) family of proteins, and regulates a variety of biological processes, including cancer cell migration, synapse formation, cell cycle progression, and responses to serum stimulation.	Arginine	131-139	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	56-62
22017372-9	2012	The arginine residue at position 118 is located in the ligand-binding domain of INSR and is highly conserved across species.	Arginine	4-12	insulin receptor	Homo sapiens	80-84
22354986-7	2012	The glycine/arginine-rich C terminus of nucleolin is required for binding, and the four RNA recognition motif domains are included in the isoform that blocks SSAT translation.	Arginine	12-20	nucleolin	Homo sapiens	40-49
22354986-7	2012	The glycine/arginine-rich C terminus of nucleolin is required for binding, and the four RNA recognition motif domains are included in the isoform that blocks SSAT translation.	Arginine	12-20	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	158-162
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Arginine	51-54	Rho family GTPase 1	Homo sapiens	0-4
21822699-6	2012	A novel pathogenetic mutation within PSEN1 gene was detected within exon 8, leading to a substitution from arginine to tryptophan (AGG > TGG: R377W), affecting a splice junction and protein function.	Arginine	107-115	presenilin 1	Homo sapiens	37-42
22333527-3	2012	Arginine 266, where the pathogenic missense mutation R266K was identified, appears to be involved in the communication between heme and the PLP-containing catalytic center.	Arginine	0-8	pyridoxal phosphatase	Homo sapiens	140-143
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Arginine	262-265	F2R like trypsin receptor 1	Homo sapiens	41-46
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Arginine	262-265	F2R like trypsin receptor 1	Homo sapiens	41-46
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Arginine	262-265	F2R like trypsin receptor 1	Homo sapiens	41-46
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Arginine	262-265	F2R like trypsin receptor 1	Homo sapiens	41-46
22155194-0	2012	Arg 901 in the AE1 C-terminal tail is involved in conformational change but not in substrate binding.	Arginine	0-3	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	15-18
22155194-1	2012	In our previous paper, we demonstrated that Arg 901 in the C-terminal tail of human AE1 (band 3, anion exchanger 1) had a functional role in conformational change during anion exchange.	Arginine	44-47	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	84-87
22155194-1	2012	In our previous paper, we demonstrated that Arg 901 in the C-terminal tail of human AE1 (band 3, anion exchanger 1) had a functional role in conformational change during anion exchange.	Arginine	44-47	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	97-114
26105453-1	2012	Regulation of heme oxygenase/carbon monoxide (ho/co) and l-arginine/nitric oxide (no) pathways by human chorionic gonadotropin (hcg) in human fetal endothelium.	Arginine	57-67	chorionic gonadotropin subunit beta 5	Homo sapiens	104-132
24671420-3	2014	Furthermore, we demonstrate that MBP is released by murine cerebellar neurons as a sumoylated dynamin-containing protein upon L1 stimulation and that this MBP cleaves L1 as a serine protease in the L1 extracellular domain at Arg(687) yielding a transmembrane fragment that promotes neurite outgrowth and neuronal survival in cell culture.	Arginine	225-228	myelin basic protein	Mus musculus	33-36
26105453-21	2012	L-arginine transport and hCAT-1 mRNA were also increased (2.8-fold and 4.5-fold, respectively) by hCG.	Arginine	0-10	chorionic gonadotropin subunit beta 5	Homo sapiens	98-101
26105453-22	2012	CONCLUSION: Upregulation of HO-1 as well as the increase in l-arginine transport and hCAT-1 mRNA in HUVECs are novel effects of hCG, which occur at physiological plasma concentrations of the hormone, as those found in the first weeks of pregnancy.	Arginine	60-70	chorionic gonadotropin subunit beta 5	Homo sapiens	128-131
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Arginine	12-22	ribosomal protein S6	Homo sapiens	132-152
22298573-3	2012	Omission of L-arginine, L-isoleucine, L-leucine, or all EAA reduced (P &lt; 0.05) mammalian target of rapamycin (mTOR; Ser2448) and ribosomal protein S6 (rpS6; Ser235/236) phosphorylation in MAC-T cells.	Arginine	12-22	ribosomal protein S6	Homo sapiens	154-158
22667467-0	2012	Pulsed ENDOR determination of the arginine location in the ferrous-NO form of neuronal NOS.	Arginine	34-42	nitric oxide synthase 1	Homo sapiens	78-90
21878453-2	2012	Through its enzymatic activity PAD2 converts myelin basic protein (MBP) arginines into citrullines - an event that may favour autoimmunity - while peptidylarginine deiminase 4 (PAD4) is involved in chromatin remodelling.	Arginine	72-81	myelin basic protein	Homo sapiens	45-65
21878453-2	2012	Through its enzymatic activity PAD2 converts myelin basic protein (MBP) arginines into citrullines - an event that may favour autoimmunity - while peptidylarginine deiminase 4 (PAD4) is involved in chromatin remodelling.	Arginine	72-81	myelin basic protein	Homo sapiens	67-70
24671420-3	2014	Furthermore, we demonstrate that MBP is released by murine cerebellar neurons as a sumoylated dynamin-containing protein upon L1 stimulation and that this MBP cleaves L1 as a serine protease in the L1 extracellular domain at Arg(687) yielding a transmembrane fragment that promotes neurite outgrowth and neuronal survival in cell culture.	Arginine	225-228	myelin basic protein	Mus musculus	155-158
24726729-0	2014	Arginine methylation of the cellular nucleic acid binding protein does not affect its subcellular localization but impedes RNA binding.	Arginine	0-8	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	28-65
24726729-1	2014	Cellular nucleic acid binding protein (CNBP) contains seven zinc finger (ZF) repeats and an arginine and glycine (RG) rich sequence between the first and the second ZF.	Arginine	92-100	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	0-37
22259020-4	2012	These studies showed that aspartate-8, histidine-11, glycine-6, proline-4, arginine-1, and proline-9, arranged in an order of importance, were critical, while threonine-2, valine-3, serine-5, and the previously assigned hydroxylation and arabinosylation residue proline-7 were trivial for the endogenous CLV3 function in SAM maintenance.	Arginine	75-83	CLAVATA3	Arabidopsis thaliana	304-308
24726729-1	2014	Cellular nucleic acid binding protein (CNBP) contains seven zinc finger (ZF) repeats and an arginine and glycine (RG) rich sequence between the first and the second ZF.	Arginine	92-100	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	39-43
24368521-0	2014	Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs.	Arginine	8-16	solute carrier family 7 member 7	Sus scrofa	67-73
22239978-12	2012	CONCLUSION: Ginsenoside Rb1 and Rg1 increased endothelial-dependent vessel dilatation through the activation of NO by modulating the PI3K/Akt/eNOS pathway and l-arginine transport in endothelial cells.	Arginine	159-169	protein phosphatase 1, regulatory subunit 3A	Mus musculus	32-35
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Arginine	98-101	defensin, alpha, 4	Mus musculus	46-62
24368521-0	2014	Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs.	Arginine	8-16	solute carrier family 7 member 1	Sus scrofa	78-84
22617883-3	2012	Nucleolin"s implication in disease is linked to its ability to associate with target RNAs via its four RNA-binding domains and its arginine/glycin-rich domain.	Arginine	131-139	nucleolin	Homo sapiens	0-9
24368521-4	2014	Dietary arginine supplementation enhanced (P &lt; 0.05) expression of jejunal SLC7A7 and ileal SLC7A1, in comparison with the control and mycotoxin groups.	Arginine	8-16	solute carrier family 7 member 7	Sus scrofa	78-84
22257012-5	2012	Further truncation of this analogue from the C terminus of the B chain to Cys(B22) and addition of an Arg(B23) led to a high-affinity, RXFP3-selective, competitive antagonist (analogue 3).	Arginine	102-105	relaxin family peptide receptor 3	Homo sapiens	135-140
24368521-4	2014	Dietary arginine supplementation enhanced (P &lt; 0.05) expression of jejunal SLC7A7 and ileal SLC7A1, in comparison with the control and mycotoxin groups.	Arginine	8-16	solute carrier family 7 member 1	Sus scrofa	95-101
24510189-8	2014	They also revealed a crucial role for a conserved asparagine-arginine containing loop (the NR-loop) in the DCP1 EVH1 domain in DCP2 activation.	Arginine	61-69	decapping mRNA 2	Homo sapiens	127-131
22357865-3	2012	Our biochemical and genetic experiments demonstrate that the intracellular tail of integrin beta1 binds directly to Arg kinase and that this interaction stimulates activity of the Arg substrate p190RhoGAP, an inactivator of the RhoA GTPase.	Arginine	116-119	Rho GTPase activating protein 35	Mus musculus	194-204
22427649-2	2012	Arg(9)   Cys (R9C) and Arg(14) deletion (R14del) mutations in PLN are associated with lethal dilated cardiomyopathy in humans.	Arginine	0-3	phospholamban	Homo sapiens	62-65
22427649-2	2012	Arg(9)   Cys (R9C) and Arg(14) deletion (R14del) mutations in PLN are associated with lethal dilated cardiomyopathy in humans.	Arginine	23-26	phospholamban	Homo sapiens	62-65
24657074-1	2014	Nitric oxide is a gaseous molecule associated with many distinct physiological functions, and is derived from L-arginine catalyzed by nitric oxide synthase (NOS).	Arginine	110-120	nitric oxide synthase 1, neuronal	Mus musculus	134-155
22579251-2	2012	Two beta blockers, carvedilol and bucindolol, show distinctive activities compared to other beta blockers and have been proposed as treatments tailored to the Arg/Gly389(8.56) polymorphism of the human beta(1)AR.	Arginine	159-162	adrenoceptor beta 1	Homo sapiens	202-211
22345554-4	2012	Mutation of the methylation site at K206 of FXR to an arginine prevented methylation by Set7/9.	Arginine	54-62	nuclear receptor subfamily 1 group H member 4	Homo sapiens	44-47
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	Arginine	41-44	cell division cycle 42	Mus musculus	116-121
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	Arginine	41-44	prolactin induced protein	Mus musculus	125-128
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	Arginine	53-56	cell division cycle 42	Mus musculus	116-121
21826105-2	2012	MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif.	Arginine	21-29	MRE11A homolog A, double strand break repair nuclease	Mus musculus	0-5
24497632-1	2014	A previous study from our laboratory reported a preferential conservation of arginine relative to lysine in the C-terminal tail (CTT) of HIV-1 envelope (Env).	Arginine	77-85	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	153-156
21826105-2	2012	MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif.	Arginine	69-77	MRE11A homolog A, double strand break repair nuclease	Mus musculus	0-5
21826105-3	2012	In this study, we report a mouse knock-in allele of Mre11 that substitutes the arginines with lysines in the GAR motif and generates the MRE11(RK) protein devoid of methylated arginines.	Arginine	79-88	MRE11A homolog A, double strand break repair nuclease	Mus musculus	52-57
21826105-3	2012	In this study, we report a mouse knock-in allele of Mre11 that substitutes the arginines with lysines in the GAR motif and generates the MRE11(RK) protein devoid of methylated arginines.	Arginine	176-185	MRE11A homolog A, double strand break repair nuclease	Mus musculus	52-57
22361732-14	2012	Uptake of L-Arg, and its metabolism by Arg1 to L-Orn and conversion to L-Pro by OAT is essential for colonic epithelial wound repair.	Arginine	10-15	arginase, liver	Mus musculus	39-43
22551548-6	2012	RESULTS: The analysis revealed a germline nonsense mutation in exon 8 at codon 306 of the codified region of the TP53 gene, causing a change of CGA to TGA (Arg Stop) in the proband, her mother, her cousin and her maternal uncle.	Arginine	156-159	T-box transcription factor 1	Homo sapiens	151-154
22112818-9	2012	The p.R408W mutation, in which substitution of straight chain arginine with bulky aromatic amine, tryptophan, at the crux of a strategic hinge site activating folding of PAH, amino acid sequence 408, was strongly associated with non-response (21/29 patients non-responsive, 12/17 genotypes non-responsive).	Arginine	62-70	phenylalanine hydroxylase	Homo sapiens	170-173
24497632-8	2014	These results provide for the first time a functional explanation to the preferred incorporation of arginine, relative to lysine, in the CTT of HIV-1 Env.	Arginine	100-108	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	150-153
24374040-4	2014	Two polymorphisms of LMP2-60 (Arg His) and LMP7-145 (Gln Lys) were identified by PCR-RFLP (RFLP, restriction fragment length polymorphism) method.	Arginine	30-33	proteasome 20S subunit beta 9	Homo sapiens	21-25
22784463-6	2012	Analysis of the TG gene of the affected twin revealed a compound heterozygous mutation, including a novel missense mutation G2687A, which is predicted to result in a glutamine to arginine substitution at codon 877, and a known nonsense mutation C7006T, predicted to result in an arginine to stop codon at codon 2317.	Arginine	179-187	thyroglobulin	Homo sapiens	16-18
22366356-1	2012	Adenosine deaminase acting on RNA 2 (ADAR2) catalyzes RNA editing at the glutamine/arginine (Q/R) site of GluA2, and an ADAR2 deficiency may play a role in the death of motor neurons in ALS patients.	Arginine	83-91	adenosine deaminase RNA specific B1	Homo sapiens	0-35
22366356-1	2012	Adenosine deaminase acting on RNA 2 (ADAR2) catalyzes RNA editing at the glutamine/arginine (Q/R) site of GluA2, and an ADAR2 deficiency may play a role in the death of motor neurons in ALS patients.	Arginine	83-91	adenosine deaminase RNA specific B1	Homo sapiens	37-42
24507716-0	2014	Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.	Arginine	0-8	topoisomerase (DNA) III beta	Mus musculus	52-57
22366356-1	2012	Adenosine deaminase acting on RNA 2 (ADAR2) catalyzes RNA editing at the glutamine/arginine (Q/R) site of GluA2, and an ADAR2 deficiency may play a role in the death of motor neurons in ALS patients.	Arginine	83-91	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	106-111
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	92-95	coagulation factor VIII	Homo sapiens	46-51
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	33-44
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	46-51
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	33-44
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	46-51
22179117-12	2012	CONCLUSION: Reduction in renal ASS/ASL and loss of renal cortex CAT1 compromises renal L-Arg synthesis and release.	Arginine	87-92	solute carrier family 7 member 1	Rattus norvegicus	64-68
22179117-13	2012	Loss of aortic CAT1 impairs L-Arg uptake.	Arginine	28-33	solute carrier family 7 member 1	Rattus norvegicus	15-19
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	33-44
24489922-8	2014	The crystal structures of the Sulfolobus and yeast RNA polymerases show that the positively charged arginine residues in subunits RpoH and Rpb5 most likely form salt bridges with negatively charged residues from subunit RpoK and Rpb1, respectively.	Arginine	100-108	DNA-directed RNA polymerase core subunit RPB5	Saccharomyces cerevisiae S288C	139-143
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	106-109	coagulation factor VIII	Homo sapiens	46-51
23047103-3	2012	The uptake of lysine and arginine by whole cells was little affected by deletion of the VBA5 gene, but was stimulated by overexpression of the VBA5 gene.	Arginine	25-33	basic amino acid transporter	Saccharomyces cerevisiae S288C	143-147
23132568-1	2012	Here, we demonstrated the involvement of the domains in Arabidopsis high-light responsive serine/arginine-rich (SR) and SR-like proteins, atSR30 and atSR45a, respectively, in subcellular and subnuclear distribution using a series of structural domain-deleted mutants.	Arginine	97-105	SERINE-ARGININE PROTEIN 30	Arabidopsis thaliana	138-144
22305799-9	2012	Arg acted downstream of receptor tyrosine kinases to regulate phosphorylation of endogenous CrkII and paxillin, adaptor proteins involved in activation of Rho family GTPases and actin reorganization.	Arginine	0-3	paxillin L homeolog	Xenopus laevis	102-110
23132568-2	2012	Judging from the localization of the transiently expressed domain-deleted mutants in onion epidermal cells, the C terminal low complexity domain rich in arginine-serine repeats (C-RS) domain of atSR30 appeared to be necessary for the nuclear localization.	Arginine	153-161	SERINE-ARGININE PROTEIN 30	Arabidopsis thaliana	194-200
24489922-8	2014	The crystal structures of the Sulfolobus and yeast RNA polymerases show that the positively charged arginine residues in subunits RpoH and Rpb5 most likely form salt bridges with negatively charged residues from subunit RpoK and Rpb1, respectively.	Arginine	100-108	DNA-directed RNA polymerase II core subunit RPO21	Saccharomyces cerevisiae S288C	229-233
24801666-4	2014	Genetic analysis revealed a novel c.277T&gt;C missense mutation causing the substitution of a hydrophobic cysteine to a hydrophilic arginine [p.(Cys93Arg)] within the highly conserved cysteine knot domain of the norrin protein.	Arginine	132-140	norrin cystine knot growth factor NDP	Homo sapiens	212-218
24977164-3	2014	One of the most important PTMs is the Arg- or Lys-methylation that occurs on arginine or lysine, respectively.	Arginine	38-41	parathymosin	Homo sapiens	26-30
23481570-7	2012	The allele types of FGFR4 amino acid 388 in 24 OSCC patients were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%).	Arginine	66-69	fibroblast growth factor receptor 4	Homo sapiens	20-25
23481570-7	2012	The allele types of FGFR4 amino acid 388 in 24 OSCC patients were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%).	Arginine	70-73	fibroblast growth factor receptor 4	Homo sapiens	20-25
23481570-7	2012	The allele types of FGFR4 amino acid 388 in 24 OSCC patients were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%).	Arginine	70-73	fibroblast growth factor receptor 4	Homo sapiens	20-25
23481570-9	2012	The patients carrying FGFR4 allele Arg/Arg or Arg/Gly at amino acid 388 were associated with advanced N stage (pathologic N2+N3), compared to Gly/Gly allele carrying group (p=0.009).	Arginine	35-38	fibroblast growth factor receptor 4	Homo sapiens	22-27
23481570-9	2012	The patients carrying FGFR4 allele Arg/Arg or Arg/Gly at amino acid 388 were associated with advanced N stage (pathologic N2+N3), compared to Gly/Gly allele carrying group (p=0.009).	Arginine	39-42	fibroblast growth factor receptor 4	Homo sapiens	22-27
23481570-9	2012	The patients carrying FGFR4 allele Arg/Arg or Arg/Gly at amino acid 388 were associated with advanced N stage (pathologic N2+N3), compared to Gly/Gly allele carrying group (p=0.009).	Arginine	39-42	fibroblast growth factor receptor 4	Homo sapiens	22-27
23481570-11	2012	In this study, FGFR4 Arg allele carrier was associated with higher N stage compared with Gly allele.	Arginine	21-24	fibroblast growth factor receptor 4	Homo sapiens	15-20
22248664-11	2012	Induction of acute pancreatitis by L-arginine required induction of macrophage migration by CCL2, via the receptor CCR2.	Arginine	35-45	chemokine (C-C motif) receptor 2	Mus musculus	115-119
22187158-5	2012	The arginine- and cysteine-rich domains of Tat were required for IkappaB-alpha and p65 association, respectively, and for sustaining the NF-kappaB activity.	Arginine	4-12	tyrosine aminotransferase	Homo sapiens	43-46
22187158-5	2012	The arginine- and cysteine-rich domains of Tat were required for IkappaB-alpha and p65 association, respectively, and for sustaining the NF-kappaB activity.	Arginine	4-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	83-86
24977164-3	2014	One of the most important PTMs is the Arg- or Lys-methylation that occurs on arginine or lysine, respectively.	Arginine	77-85	parathymosin	Homo sapiens	26-30
22188495-8	2012	Mutational analysis for the WRN gene revealed a homozygous nucleotide substitution 3190C&gt;T in exon 24, resulting in a protein product with replacement of an arginine residue at position 573 by termination codon (Arg987Ter).	Arginine	160-168	WRN RecQ like helicase	Homo sapiens	28-31
25126568-8	2014	The mechanism of rADI cytotoxicity in the presence of NMDA is caused by the inhibition of NO production via nNOS mediated by the NMDA receptor, which was abolished when extracellular arginine was absent, even in the presence of citrulline.	Arginine	183-191	nitric oxide synthase 1	Homo sapiens	108-112
24727379-7	2014	The structure establishes that the Tat-TAR recognition motif (TRM) in Cyclin T1 interacts with both Tat and AFF4, leading to the exposure of arginine side chains for binding to TAR RNA.	Arginine	141-149	tyrosine aminotransferase	Homo sapiens	100-103
21965298-9	2012	We propose that arginine methylation by PRMT1 participates in the nuclear-cytoplasmic shuttling of FUS, particularly of ALS6-associated mutants, and thus contributes to the toxic gain of function conferred by these disease-causing mutations.	Arginine	16-24	fused in sarcoma	Mus musculus	99-102
22079445-4	2012	MATERIALS AND METHODS: Compounds X-D-Arg-D-Phe-OMe, where X=residue of lauric or myristic acid or 9-fluorenylmethoxycarbonyl, have been synthesized by conventional peptide synthesis in solution and their comparative inhibitory analysis in relation to thrombin, factor X, plasmin and trypsin has been conducted.	Arginine	37-40	plasminogen	Homo sapiens	271-278
23926880-2	2014	We have recently shown that synthetic antimicrobial peptides named PD1-PD4 derived from the thrombin-induced human platelet-derived antimicrobial proteins, and repeats of Arg-Trp (RW1-RW5) demonstrate microbicidal activity against selected bacteria and viruses.	Arginine	171-174	transmembrane protein 131	Homo sapiens	180-187
22318724-8	2012	We demonstrate that the exon 8-encoded C-terminal arginine is essential for the interaction of VEGF-A with Nrp1 and mediates high affinity Nrp binding.	Arginine	50-58	neuropilin 1	Homo sapiens	107-111
22318724-8	2012	We demonstrate that the exon 8-encoded C-terminal arginine is essential for the interaction of VEGF-A with Nrp1 and mediates high affinity Nrp binding.	Arginine	50-58	neuropilin 1	Homo sapiens	107-110
22409427-3	2012	Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells.	Arginine	243-246	F2R like trypsin receptor 1	Homo sapiens	41-46
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	75-78	proteasome 20S subunit beta 9	Homo sapiens	34-38
21841822-9	2012	Furthermore, mutating four known acetylated lysine residues (K242, K259, K290 and K569) of FOXO3 into arginines to mimic deacetylated FOXO3 resulted in enhanced Skp2 binding but with inhibition of FOXO3 ubiquitination; this suggests that some or all of these four lysine residues are likely the sites for ubiquitination.	Arginine	102-111	S-phase kinase associated protein 2	Homo sapiens	161-165
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	79-82	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	79-82	proteasome 20S subunit beta 9	Homo sapiens	34-38
22235122-6	2012	We found that the C-terminal 16-amino acid fragment of Rad27, a highly polybasic region due to the presence of multiple positively charged lysine and arginine residues, was sufficient and necessary for the stimulation of both Rad27 and Dna2.	Arginine	150-158	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	236-240
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	79-82	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	79-82	proteasome 20S subunit beta 9	Homo sapiens	34-38
24809174-3	2014	It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg - 53.3%, Arg/His - 43.5%, His/His - 6.7% in control and Arg/Arg - 55.9%, Arg/His - 34.3%, His/His - 9.8% in IS group (P &gt; 0.05).	Arginine	79-82	proteasome 20S subunit beta 9	Homo sapiens	34-38
24097435-0	2014	PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.	Arginine	26-34	protein arginine N-methyltransferase 5	Mus musculus	0-5
22262851-4	2012	The different substrate specificities of the two isoforms, which share 87% identical amino acids, were essentially swapped by exchanging a single residue located at position 179 that is arginine in ORC1 and glutamine in ORC2.	Arginine	186-194	origin recognition complex subunit 1	Homo sapiens	198-202
22262851-4	2012	The different substrate specificities of the two isoforms, which share 87% identical amino acids, were essentially swapped by exchanging a single residue located at position 179 that is arginine in ORC1 and glutamine in ORC2.	Arginine	186-194	origin recognition complex subunit 2	Homo sapiens	220-224
22279135-0	2012	Dietary L-arginine supplementation during gestation in mice enhances reproductive performance and Vegfr2 transcription activity in the fetoplacental unit.	Arginine	8-18	kinase insert domain protein receptor	Mus musculus	98-104
22279135-2	2012	To this end, we sought to determine if dietary L-arginine alters fetoplacental vascular endothelial growth factor receptor-2 (Vegfr2) transcription activity.	Arginine	47-57	kinase insert domain protein receptor	Mus musculus	79-124
22279135-2	2012	To this end, we sought to determine if dietary L-arginine alters fetoplacental vascular endothelial growth factor receptor-2 (Vegfr2) transcription activity.	Arginine	47-57	kinase insert domain protein receptor	Mus musculus	126-132
24107421-2	2013	Gene targeting of the catalytic subunit (Slc7a9) in mice leads to excessive excretion of cystine, lysine, arginine, and ornithine.	Arginine	106-114	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	Mus musculus	41-47
22279135-9	2012	During d 12-18, arginine supplementation increased (P &lt; 0.05) the mean total Vegfr2 transcription activity and Vegfr2 transcription activity corrected for fetoplacental mass.	Arginine	16-24	kinase insert domain protein receptor	Mus musculus	80-86
22279135-9	2012	During d 12-18, arginine supplementation increased (P &lt; 0.05) the mean total Vegfr2 transcription activity and Vegfr2 transcription activity corrected for fetoplacental mass.	Arginine	16-24	kinase insert domain protein receptor	Mus musculus	114-120
22279135-10	2012	Moreover, mice in the +Arg group had an earlier rise in Vegfr2 transcription activity.	Arginine	23-26	kinase insert domain protein receptor	Mus musculus	56-62
24107421-8	2013	Loss of function of b(0,+)AT reduced transport of cystine and arginine in renal BBMVs and completely abolished the exchanger activity of dibasic amino acids with neutral amino acids.	Arginine	62-70	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	Mus musculus	20-28
24189068-1	2013	Epigenetic regulation mediated by lysine- and arginine-specific enzymes plays an essential role in tumorigenesis, and enhanced expression of the type II protein arginine methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been associated with increased cell proliferation and survival.	Arginine	46-54	protein arginine N-methyltransferase 5	Mus musculus	188-193
22038625-1	2012	We have previously shown in the post ischemic gut that enteral arginine enhanced injury and inflammation via c-Jun/AP-1 and abrogated peroxisome proliferator-activated receptor (PPAR) gamma activity.	Arginine	63-71	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-119
24196717-6	2013	Neonatal CD71(+) cells express the enzyme arginase-2, and arginase activity is essential for the immunosuppressive properties of these cells because molecular inhibition of this enzyme or supplementation with L-arginine overrides immunosuppression.	Arginine	209-219	transferrin receptor	Mus musculus	9-13
22179613-3	2012	Here, we report that LANA is subject to arginine methylation by protein arginine methyltransferase 1 in vitro and in vivo.	Arginine	40-48	LANA	Human gammaherpesvirus 8	21-25
24013475-4	2013	The EGF dressing (with EGF, Arg, VC) significantly enhanced the production of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) by CDS as compared to the EGF-free dressing (with Arg, VC).	Arginine	28-31	hepatocyte growth factor	Homo sapiens	124-148
22396406-8	2012	Local application of Arg or actin polymerization inhibitors exaggerated cocaine sensitization, as did reduced gene dosage of the Arg substrate, p190RhoGAP.	Arginine	21-24	Rho GTPase activating protein 35	Mus musculus	144-154
22396406-8	2012	Local application of Arg or actin polymerization inhibitors exaggerated cocaine sensitization, as did reduced gene dosage of the Arg substrate, p190RhoGAP.	Arginine	129-132	Rho GTPase activating protein 35	Mus musculus	144-154
22396422-4	2012	Here we report the characterization of a novel motif containing three arginine residues (405RRR407) within the GABA(A)R beta3-subunit intracellular domain (ICD), responsible for the interaction with AP2 and GABA(A)R internalization.	Arginine	70-78	fatty acid binding protein 4	Rattus norvegicus	199-202
24013475-4	2013	The EGF dressing (with EGF, Arg, VC) significantly enhanced the production of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) by CDS as compared to the EGF-free dressing (with Arg, VC).	Arginine	28-31	hepatocyte growth factor	Homo sapiens	150-153
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	86-89	coagulation factor VIII	Homo sapiens	42-53
22147710-5	2012	However, mutation of several residues displayed distinct pathway responses with respect to wild type receptor, including Arg-299 and Tyr-305, where mutation significantly enhanced both GLP-1(1-36)-NH(2)- and GLP-1(7-36)-NH(2)-mediated signaling bias for pERK1/2.	Arginine	121-124	glucagon like peptide 1 receptor	Homo sapiens	185-190
22147710-5	2012	However, mutation of several residues displayed distinct pathway responses with respect to wild type receptor, including Arg-299 and Tyr-305, where mutation significantly enhanced both GLP-1(1-36)-NH(2)- and GLP-1(7-36)-NH(2)-mediated signaling bias for pERK1/2.	Arginine	121-124	glucagon like peptide 1 receptor	Homo sapiens	208-213
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	86-89	coagulation factor VIII	Homo sapiens	55-60
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor VIII	Homo sapiens	42-53
22112761-4	2012	Here, we investigate a gene delivery agent, arginine-grafted bioreducible poly (disulfide amine) polymer (ABP) for siRNA delivery as it contains arginine residues with siRNA binding properties.	Arginine	44-52	amine oxidase copper containing 1	Homo sapiens	106-109
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor VIII	Homo sapiens	55-60
22112761-4	2012	Here, we investigate a gene delivery agent, arginine-grafted bioreducible poly (disulfide amine) polymer (ABP) for siRNA delivery as it contains arginine residues with siRNA binding properties.	Arginine	145-153	amine oxidase copper containing 1	Homo sapiens	106-109
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor VIII	Homo sapiens	42-53
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor VIII	Homo sapiens	55-60
24260115-8	2013	Docking analyses showed different modes of interaction of the compounds with the active sites of ARG-L and ARG-1.	Arginine	97-100	arginase 1	Rattus norvegicus	107-112
22348173-1	2012	Human recombinant arginase I cobalt coupled to polyethylene glycol 5000 (HuArg I [Co]-PEG5000) achieved potent in vitro depletion of arginine from tissue culture medium and cytotoxicity to many cancer cell lines.	Arginine	133-141	arginase, liver	Mus musculus	18-28
24140420-7	2013	Our study reveals that posttranslational arginine methylation regulates the association of the cargo-receptor complex with the scaffold protein, providing a mechanism for modulating degradation efficiency in selective autophagy.	Arginine	41-49	Protein sepa-1	Caenorhabditis elegans	101-109
21945681-0	2012	Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer.	Arginine	124-132	glucagon	Mus musculus	10-15
23916785-2	2013	Arg is activated downstream of integrin alpha3beta1 receptors and it regulates the neuronal actin cytoskeleton by directly binding F-actin and via phosphorylation of substrates including p190RhoGAP and cortactin.	Arginine	0-3	Rho GTPase activating protein 35	Mus musculus	187-197
22139843-4	2012	However, when transfected into cells, a mutant version of Cx43 with all lysines converted to arginines behaved similarly to wild type in the presence of proteasomal and lysosomal inhibitors, indicating that ubiquitination of Cx43 did not appear to be playing a role in gap junction stability.	Arginine	93-102	gap junction protein alpha 1	Homo sapiens	58-62
23979600-8	2013	Replacement of two major acetylation sites of Rad53 with arginine reduces its activity and further suppresses the adaptation defect of rpd3Delta cells, indicating that Rpd3 facilitates adaptation by preventing Rad53 overactivation.	Arginine	57-65	checkpoint kinase 2	Homo sapiens	46-51
23979600-8	2013	Replacement of two major acetylation sites of Rad53 with arginine reduces its activity and further suppresses the adaptation defect of rpd3Delta cells, indicating that Rpd3 facilitates adaptation by preventing Rad53 overactivation.	Arginine	57-65	checkpoint kinase 2	Homo sapiens	210-215
23133559-7	2012	Taken together, these findings provide an insight into the link between histone arginine methylation by PRMT5 and transcriptional regulation of the circadian Per1 gene.	Arginine	80-88	protein arginine N-methyltransferase 5	Mus musculus	104-109
23897760-8	2013	Fasting human C-peptide levels were similar between groups throughout the study, but only NKX6.1-high grafts displayed robust meal-, glucose- and arginine-responsive insulin secretion as early as 3 months post-transplant.	Arginine	146-154	NK6 homeobox 1	Homo sapiens	90-96
22363466-4	2012	METHODOLOGY/PRINCIPAL FINDINGS: Here, we report functional implications of lysine modifications of the human AID protein by generating a panel of lysine to arginine mutants of AID and assessment of their catalytic class switch activity.	Arginine	156-164	activation induced cytidine deaminase	Homo sapiens	109-112
24074032-2	2013	SRPK1 has been shown to phosphorylate the prototype SR protein SRSF1 using a directional mechanism in which 11 serines flanked by arginines are sequentially fed from a docking groove in the large lobe of the kinase domain to the active site.	Arginine	130-139	SRSF protein kinase 1	Homo sapiens	0-5
23150776-6	2012	Thus arginine methylation is shown to be an important switch in regulation of Dishevelled function and Wnt signaling.	Arginine	5-13	Wnt family member 3A	Homo sapiens	103-106
24079887-7	2013	One of the sites is the C-terminal arginine, liberated by furin cleavage, and the other is a novel upstream helical motif centered on the intermolecular disulfide.	Arginine	35-43	furin, paired basic amino acid cleaving enzyme	Homo sapiens	58-63
22623885-2	2012	The aim of the present paper was to estimate the activity of the enzymes of adenine nucleotide metabolism: 5"-nucleotidase (5"-NU), adenosine deaminase (ADA), AMP deaminase, and xanthine oxidase (XO), during dietary intake of L-arginine for a period of four weeks of male Wistar rats.	Arginine	226-236	5' nucleotidase, ecto	Rattus norvegicus	107-122
24079887-8	2013	Using a novel chimeric C-furSema, we demonstrate that combining a single C-terminal arginine with the helical motif is necessary and sufficient for potent inhibition of binding of VEGF-A to Nrp1.	Arginine	84-92	neuropilin 1	Homo sapiens	190-194
24082117-6	2013	Nucleolin, a protein with histone chaperone activity, interacts with RAD50 via its arginine-glycine rich domain and is recruited to DSBs rapidly in an MRE11-NBS1-RAD50 complex-dependent manner.	Arginine	83-91	nucleolin	Homo sapiens	0-9
22041901-1	2011	PRMT5 is a type II protein arginine methyltranferase that catalyzes monomethylation and symmetric dimethylation of arginine residues.	Arginine	27-35	protein arginine N-methyltransferase 5	Mus musculus	0-5
24082117-6	2013	Nucleolin, a protein with histone chaperone activity, interacts with RAD50 via its arginine-glycine rich domain and is recruited to DSBs rapidly in an MRE11-NBS1-RAD50 complex-dependent manner.	Arginine	83-91	RAD50 double strand break repair protein	Homo sapiens	69-74
21900454-7	2011	The arginine/ADMA ratio correlated with cortical flow, lipocalin-2, and creatinine rises.	Arginine	4-12	lipocalin 2	Rattus norvegicus	55-66
23872361-3	2013	In the present study we examined the expression of p62 in the mouse lens and compared its expression in wild-type lenses with that in lenses from knock-in mice with an arginine to glycine mutation in alphaB-crystallin (alphaB-R120G) that is known to cause human hereditary cataract.	Arginine	168-176	crystallin, alpha B	Mus musculus	200-217
24098712-4	2013	We show that while arginine residues in the RGG box domain of hnRNP A1 and A3 are almost exhaustively, asymmetrically dimethylated, hnRNP A2 is dimethylated at only a single residue (Arg-254) and this modification is conserved across cell types.	Arginine	19-27	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	62-70
23952283-5	2013	We further demonstrate the use of the metamaterials for fingerprinting and detection of the arginine-glycine-glycine domain of nucleolin, a cancer biomarker that specifically binds to a G-quadruplex, with the picomolar sensitivity.	Arginine	92-100	nucleolin	Homo sapiens	127-136
24044607-0	2013	Molecular dynamics simulations on the Tre1 G protein-coupled receptor: exploring the role of the arginine of the NRY motif in Tre1 structure.	Arginine	97-105	Trapped in endoderm 1	Drosophila melanogaster	38-42
24044607-0	2013	Molecular dynamics simulations on the Tre1 G protein-coupled receptor: exploring the role of the arginine of the NRY motif in Tre1 structure.	Arginine	97-105	Trapped in endoderm 1	Drosophila melanogaster	126-130
24044607-6	2013	Since the missing amino acids in Tre1sctt include the arginine that is part of the D/E/NRY motif in Tre1, molecular dynamics simulations were performed to explore the hypothesis that these amino acids are involved in salt bridge formation and help maintain Tre1 structure.	Arginine	54-62	Trapped in endoderm 1	Drosophila melanogaster	33-37
24044607-6	2013	Since the missing amino acids in Tre1sctt include the arginine that is part of the D/E/NRY motif in Tre1, molecular dynamics simulations were performed to explore the hypothesis that these amino acids are involved in salt bridge formation and help maintain Tre1 structure.	Arginine	54-62	Trapped in endoderm 1	Drosophila melanogaster	100-104
24025624-1	2013	BACKGROUND: Arginine Rich Motif (ARM) of HIV-1 Tat and Rev are extensively studied linear motifs (LMs).	Arginine	12-20	Rev	Human immunodeficiency virus 1	55-58
24039885-3	2013	While investigating the role of Slk19 post-translational modification on Cdc14 regulation, we found that a triple point mutant of SLK19, slk19(3R) (three lysine-to-arginine mutations), strongly affects Cdc14 localization during late anaphase and mitotic exit.	Arginine	164-172	Slk19p	Saccharomyces cerevisiae S288C	130-135
24039885-3	2013	While investigating the role of Slk19 post-translational modification on Cdc14 regulation, we found that a triple point mutant of SLK19, slk19(3R) (three lysine-to-arginine mutations), strongly affects Cdc14 localization during late anaphase and mitotic exit.	Arginine	164-172	Slk19p	Saccharomyces cerevisiae S288C	137-142
24016303-6	2013	We have studied if the function of mutant PEX1, PEX6 and PEX12 can be improved by promoting protein folding using the chemical chaperone arginine.	Arginine	137-145	peroxisomal biogenesis factor 1	Homo sapiens	42-46
24016303-9	2013	RESULTS: Peroxisome biogenesis and function in fibroblasts with mild missense mutations in PEX1, 6 and 12 can be improved by arginine.	Arginine	125-133	peroxisomal biogenesis factor 1	Homo sapiens	91-95
23831616-10	2013	Correlation analysis showed that Arg1 ablation disturbed the coordinated pulmonary response to ovalbumin challenges, suggesting arginine (metabolite) dependence of this response.	Arginine	128-136	arginase, liver	Mus musculus	33-37
22778693-1	2012	The Zinc finger, RAN-binding domain-containing protein 2 (ZRANB2), contains arginine/serine-rich (RS) domains that mediate its function in the regulation of alternative splicing.	Arginine	76-84	zinc finger RANBP2-type containing 2	Homo sapiens	58-64
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Arginine	296-304	Tudor staphylococcal nuclease	Drosophila melanogaster	203-207
23831616-11	2013	Arg1 ablation in the lung improved peripheral lung function and affected arginine metabolism but had little effect on airway inflammation.	Arginine	73-81	arginase, liver	Mus musculus	0-4
23270585-3	2013	The genetic locus of Fc-gamma RIIA consists of two allelic genes: 131-Arg (R131) and 131-His (H131).	Arginine	70-73	Fc gamma receptor IIa	Homo sapiens	21-34
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Arginine	296-304	l(2)46Cp	Drosophila melanogaster	431-438
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Arginine	124-127	RNA binding protein with serine rich domain 1	Homo sapiens	33-43
22611952-7	2012	The Arg/His genotype of XRCC2 (OR = 2.16, 95% CI = 1.48-3.16) and Thr/Met of XRCC3 increased the risk of type I breast cancer occurrence (OR = 2.33, 95% CI = 1.60-3.41).	Arginine	4-7	X-ray repair cross complementing 2	Homo sapiens	24-29
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Arginine	124-127	SRSF protein kinase 1	Homo sapiens	64-69
23707382-8	2013	The data establish a new view of SR protein regulation in which SRPK1 and CLK1 partition activities based on Ser-Pro versus Arg-Ser placement rather than on N- and C-terminal preferences along the RS domain.	Arginine	124-127	CDC like kinase 1	Homo sapiens	74-78
23750013-3	2013	SMN belongs to the Tudor domain protein family, whose members are known to interact with methylated arginine (R) or lysine (K) residues.	Arginine	100-108	survival of motor neuron 1, telomeric	Homo sapiens	0-3
22571433-8	2012	Computer modeling suggested enzyme exosite residues 96 (Arg in L-HEP, Lys in L-BEP) and 219 (Lys in L-HEP, Gln in L-BEP) to be responsible for these differences in enteropeptidase catalytic activity.	Arginine	56-59	transmembrane serine protease 15	Homo sapiens	164-179
22738901-5	2012	Arg increases expression of GTP cyclohydrolase 1 (GCH1) and IFNT mRNAs while Arg and Gluc increase ornithine decarboxylase, nitric oxide synthase 2, and GCH1 mRNAs and proteins by Tr cells.	Arginine	0-3	GTP cyclohydrolase 1	Sus scrofa	28-48
23866019-3	2013	As the only known member of the PRMT enzyme family to catalyze the formation of mono- and symmetrically dimethylated arginine residues, PRMT5 is also mechanistically unique.	Arginine	117-125	Protein arginine N-methyltransferase 5	Caenorhabditis elegans	136-141
22738901-5	2012	Arg increases expression of GTP cyclohydrolase 1 (GCH1) and IFNT mRNAs while Arg and Gluc increase ornithine decarboxylase, nitric oxide synthase 2, and GCH1 mRNAs and proteins by Tr cells.	Arginine	0-3	GTP cyclohydrolase 1	Sus scrofa	50-54
22738901-5	2012	Arg increases expression of GTP cyclohydrolase 1 (GCH1) and IFNT mRNAs while Arg and Gluc increase ornithine decarboxylase, nitric oxide synthase 2, and GCH1 mRNAs and proteins by Tr cells.	Arginine	77-80	GTP cyclohydrolase 1	Sus scrofa	153-157
23472611-6	2013	However, chickens supplemented with L-Arg had lower abdominal fat content, plasma triglyceride (TG), total cholesterol (TC) concentrations, hepatic FAS mRNA expression and increased heart carnitine palmitoyl transferase1 (CPT1) and 3-hydroxyacyl-CoA dehydrogenase (3HADH) mRNA expression.	Arginine	36-41	carnitine palmitoyltransferase 1A	Gallus gallus	222-226
22090118-8	2012	Mutations of arginine residues within the putative DNA recognition helix of vIRF4 or the invariant cysteines of the adjacent CxxC motif abolish cooperation with RTA, in the latter case by preventing self-association.	Arginine	13-21	vIRF-4	Human gammaherpesvirus 8	76-81
22090118-8	2012	Mutations of arginine residues within the putative DNA recognition helix of vIRF4 or the invariant cysteines of the adjacent CxxC motif abolish cooperation with RTA, in the latter case by preventing self-association.	Arginine	13-21	RNA binding fox-1 homolog 2	Homo sapiens	161-164
22815628-7	2012	A C&gt;T substitution at codon 240 converts an arginine codon (CGA) to a termination codon (TGA).The same mutation was detected in the sporadic patient by chance.	Arginine	47-55	T-box transcription factor 1	Homo sapiens	92-95
23472611-6	2013	However, chickens supplemented with L-Arg had lower abdominal fat content, plasma triglyceride (TG), total cholesterol (TC) concentrations, hepatic FAS mRNA expression and increased heart carnitine palmitoyl transferase1 (CPT1) and 3-hydroxyacyl-CoA dehydrogenase (3HADH) mRNA expression.	Arginine	36-41	hydroxyacyl-CoA dehydrogenase	Gallus gallus	266-270
23707396-2	2013	Arg promotes actin-based cell protrusions and spreading, and inhibits cell migration by attenuating stress fiber formation and contractility via activation of the RhoA inhibitor, p190RhoGAP, and by regulating focal adhesion dynamics also via CrkII phosphorylation.	Arginine	0-3	Rho GTPase activating protein 35	Homo sapiens	179-189
23118920-4	2012	Preventing sumoylation by mutating the SUMO acceptor K6 to arginine resulted in downregulation of FOXA2 protein but not RNA expression in INS-1E insulinoma cells.	Arginine	59-67	forkhead box A2	Rattus norvegicus	98-103
23824602-4	2013	We found that NAE can accommodate diverse changes in the Nedd8 C-terminal sequence (71 LALRGG76), including Arg and Ile replacing Leu71, Leu, Ser, and Gln replacing Ala72, and substitutions by bulky aromatic residues at positions 73 and 74.	Arginine	108-111	NEDD8 ubiquitin like modifier	Homo sapiens	57-62
23687382-4	2013	Experiments performed with botulinum neurotoxins led to the identification of one arginine residue in SNAP-25 and one aspartate residue in syntaxin (R206 and D253 in Drosophila melanogaster).	Arginine	82-90	Synaptosomal-associated protein 25kDa	Drosophila melanogaster	102-109
21923750-4	2011	L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cells, CAT-1 and CAT-2.	Arginine	0-5	solute carrier family 7 member 2	Homo sapiens	144-149
23696643-5	2013	PID bound to iNOS heme to generate an irreversible PID-iNOS monomer complex that could not be converted to active dimers by tetrahydrobiopterin (H4B) and l-arginine (Arg).	Arginine	154-164	metastasis associated 1 family member 2	Homo sapiens	0-3
23696643-5	2013	PID bound to iNOS heme to generate an irreversible PID-iNOS monomer complex that could not be converted to active dimers by tetrahydrobiopterin (H4B) and l-arginine (Arg).	Arginine	166-169	metastasis associated 1 family member 2	Homo sapiens	0-3
23696643-8	2013	PID binding rate was also sensitive to H4B and Arg site occupancy.	Arginine	47-50	metastasis associated 1 family member 2	Homo sapiens	0-3
23541506-6	2013	In contrast, monomethylation of arginine residue at eta nitrogen results in reduced binding affinity originating exclusively from a less favourable enthalpy change leaving entropic component unaffected.	Arginine	32-40	endothelin receptor type A	Homo sapiens	52-55
23689818-6	2013	Using chimeric and point mutated variants of TT2 and PAP4 we found that exchange of a single amino acid, Gly/Arg(39) in the R2 domain combined with an exchange of a four amino acid motif in the R3 domain, could swap the pathway selection of TT2 and PAP4, thereby converting in planta specificity of the PA towards the anthocyanin pathway and vice versa.	Arginine	109-112	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	45-48
23785515-7	2013	The adaptive changes in liver function were accompanied by an increased expression of genes involved in arginine metabolism (Asl, Got1, Gpt2, Glud1, Arg1, and Arg2) and transport (Slc25a13, Slc25a15, and Slc3a2), whereas no such changes were found in the intestine.	Arginine	104-112	glutamic pyruvate transaminase (alanine aminotransferase) 2	Mus musculus	136-140
21813706-3	2011	Here, we report the generation and characterization of a recombinant RV expressing cDNA-derived VP4 with a modified cleavage site (arginine at position 247) recognized by endogenous furin as well as exogenous trypsin.	Arginine	131-139	furin, paired basic amino acid cleaving enzyme	Homo sapiens	182-187
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-62
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	0-3	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-136
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	4-7	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	57-62
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	4-7	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-136
22977637-6	2011	The risk of prostate cancer in individuals carrying the SULT1A1(*)2 allele (His(213) allele) was determined by combining the SULT1A1(*)1/SULT1A1(*)2 (Arg/His(213)) and SULT1A1(*)2/SULT1A1(*)2 (His/His(213)) genotypes.	Arginine	150-153	sulfotransferase family 1A member 1	Homo sapiens	56-63
21801698-4	2011	METHODS: Acute pancreatitis was induced in CD11c.DTR mice using caerulein or L-arginine; DCs were depleted by administration of diphtheria toxin.	Arginine	77-87	integrin alpha X	Mus musculus	43-48
21843643-6	2011	Our structure validates inhibitor studies that identified Arg-120 as a molecular determinant for time-dependent inhibition of COX-2 by NS-398.	Arginine	58-61	cytochrome c oxidase II, mitochondrial	Mus musculus	126-131
21800130-2	2011	So far, only two functional alleles differing at only one amino acid position (non-synonymous mutation) in the alpha2 heavy chain domain, where an arginine in position 107 in HLA-E*0101 is replaced by a glycine in HLA-E*0103, have been reported.	Arginine	147-155	major histocompatibility complex, class I, E	Homo sapiens	175-180
21813128-1	2011	OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa).	Arginine	44-52	Fc gamma receptor IIa	Homo sapiens	121-141
21840768-2	2011	Agmatine, a biogenic amine formed by decarboxylation of L-arginine by arginine decarboxylase, also has anticonvulsant effects.	Arginine	56-66	antizyme inhibitor 2	Mus musculus	70-92
21636960-3	2011	Plasma insulin concentrations increased rapidly 2 to 4 min after injection of arginine, then decreased to the basal levels at 20 min in all five cats.	Arginine	78-86	insulin	Felis catus	7-14
21636960-4	2011	Insulin peak responses were significantly greater in arginine injections than in normal saline (P&lt;0.01).	Arginine	53-61	insulin	Felis catus	0-7
21636960-5	2011	Areas under the curve (AUC) of plasma insulin concentrations from 0 to 10 min after injection of arginine were significantly larger than after injection of normal saline (P&lt;0.01) and glucose (P&lt;0.05).	Arginine	97-105	insulin	Felis catus	38-45
21636960-6	2011	Increases in AUC of plasma insulin concentration from 0 to 60 min were observed after injection of arginine, leucine, alanine, and fat emulsion.	Arginine	99-107	insulin	Felis catus	27-34
21636960-9	2011	Given the risk of glucose toxication and required time for testing, the intravenous arginine tolerance test may be useful for estimation of insulin responses in cats.	Arginine	84-92	insulin	Felis catus	140-147
21515380-5	2011	In this study we have improved the efficiency of fusion proteins cleavage by enteropeptidase by substitution of the Lys residue by Arg in specific cleavage sequence (Asp)(4)-Lys.	Arginine	131-134	transmembrane serine protease 15	Homo sapiens	77-92
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Arginine	188-191	transmembrane serine protease 15	Bos taurus	94-109
23028781-7	2012	Structure comparison and mutagenesis identify an Arg neighboring to the Sirt5 nicotinamide binding pocket as a mediator of nicotinamide resistance, and statistical sequence analyses along with testing further Sirtuins reveal a network of coevolved residues likely defining a nicotinamide-insensitive Sirtuin deacetylase family.	Arginine	49-52	sirtuin 5	Homo sapiens	72-77
23028781-8	2012	The same Arg was recently reported to render Sirt5 a preferential desuccinylase, and we find that this Sirt5 activity is highly sensitive to nicotinamide inhibition.	Arginine	9-12	sirtuin 5	Homo sapiens	45-50
23028781-8	2012	The same Arg was recently reported to render Sirt5 a preferential desuccinylase, and we find that this Sirt5 activity is highly sensitive to nicotinamide inhibition.	Arginine	9-12	sirtuin 5	Homo sapiens	103-108
23028781-9	2012	Analysis of Sirt5 structures and activity data suggest that an Arg/succinate interaction is the molecular basis of the differential nicotinamide sensitivities of the two Sirt5 activities.	Arginine	63-66	sirtuin 5	Homo sapiens	12-17
23028781-9	2012	Analysis of Sirt5 structures and activity data suggest that an Arg/succinate interaction is the molecular basis of the differential nicotinamide sensitivities of the two Sirt5 activities.	Arginine	63-66	sirtuin 5	Homo sapiens	170-175
22084441-4	2011	As a possible substitute, rat and mouse NKG2C and -E contain an arginine residue in the transition between the transmembrane and stalk regions.	Arginine	64-72	killer cell lectin-like receptor subfamily C, member 2	Mus musculus	40-52
21898593-2	2011	We have previously shown that the impaired Arg-Gly-Asp (RGD) sequence of osteopontin inhibits renal crystal formation by using OPN-transgenic mice and OPN-knockout (OPN-KO) mice.	Arginine	43-46	secreted phosphoprotein 1	Mus musculus	73-84
22174695-2	2011	Here we show that a single nucleotide germline polymorphism (SNP) substituting an arginine (R) for glycine (G) in the FGFR4 transmembrane domain can alter pituitary cell growth and hormone production.	Arginine	82-90	fibroblast growth factor receptor 4	Homo sapiens	118-123
22076378-5	2011	The preference for succinyl and malonyl groups was explained by the presence of an arginine residue (Arg(105)) and tyrosine residue (Tyr(102)) in the acyl pocket of Sirt5.	Arginine	83-91	sirtuin 5	Homo sapiens	165-170
22076378-5	2011	The preference for succinyl and malonyl groups was explained by the presence of an arginine residue (Arg(105)) and tyrosine residue (Tyr(102)) in the acyl pocket of Sirt5.	Arginine	101-104	sirtuin 5	Homo sapiens	165-170
21856816-4	2011	Transgenic mice expressing a dominant-negative BMPRII gene (with an arginine to termination mutation at amino acid 899) in smooth muscle by a tetracycline-gene switch system (SM22-tet-BMPR2(R899X) mice) were examined.	Arginine	68-76	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	47-53
22069260-3	2011	Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 basic amino acid (arginine) of the peptide bound in pocket 9 of I-Ag7.	Arginine	128-136	I-ag7	Mus musculus	61-66
22069260-3	2011	Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 basic amino acid (arginine) of the peptide bound in pocket 9 of I-Ag7.	Arginine	128-136	I-ag7	Mus musculus	174-179
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Arginine	113-116	transforming growth factor, beta 1	Mus musculus	212-221
21945444-4	2011	It was also found by affinity analysis that Sema3A peptide binds to NRP1, and two arginines (372R and 377R) in Sema3A peptide are involved in the interaction with NRP1 protein.	Arginine	82-91	semaphorin 3A	Homo sapiens	111-117
21945444-4	2011	It was also found by affinity analysis that Sema3A peptide binds to NRP1, and two arginines (372R and 377R) in Sema3A peptide are involved in the interaction with NRP1 protein.	Arginine	82-91	neuropilin 1	Homo sapiens	163-167
20696468-7	2011	The immunohistochemical study revealed increased immunostaining of TRAIL and DR5 in osteoblastic cells of the diaphysis (pre-metaphysis) and epiphysis treated with STZ and L-NAME, related to activation of osteoblastic apoptotic death, while the group receiving L-arginine was comparable to the control group and the higher indications of iNOS activity that may reflect its induction by L-arginine administration.	Arginine	261-271	TNF superfamily member 10	Rattus norvegicus	67-72
20696468-7	2011	The immunohistochemical study revealed increased immunostaining of TRAIL and DR5 in osteoblastic cells of the diaphysis (pre-metaphysis) and epiphysis treated with STZ and L-NAME, related to activation of osteoblastic apoptotic death, while the group receiving L-arginine was comparable to the control group and the higher indications of iNOS activity that may reflect its induction by L-arginine administration.	Arginine	386-396	TNF superfamily member 10	Rattus norvegicus	67-72
21813128-1	2011	OBJECTIVE: A gene polymorphism substituting arginine (R) for histidine (H) at position 131 has been described within the Fcgamma receptor IIa (FcgammaRIIa).	Arginine	44-52	Fc gamma receptor IIa	Homo sapiens	143-154
21870783-1	2011	The binuclear manganese metalloenzyme human arginase I (HAI) is a potential protein drug for cancer chemotherapy, in that it is capable of depleting extracellular l-Arg levels in the microenvironment of tumor cells that require this nutrient to thrive.	Arginine	163-168	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	56-59
21870783-5	2011	A different catalytic mechanism is proposed for Co(2+)(2)-HAI compared with that of Mn(2+)(2)-HAI, including an unusual Nepsilon-Co(2+) coordination mode, to rationalize the lower K(M) value of L-Arg and the lower K(i) value of L-Orn.	Arginine	194-199	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	58-61
21870783-5	2011	A different catalytic mechanism is proposed for Co(2+)(2)-HAI compared with that of Mn(2+)(2)-HAI, including an unusual Nepsilon-Co(2+) coordination mode, to rationalize the lower K(M) value of L-Arg and the lower K(i) value of L-Orn.	Arginine	194-199	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	94-97
21515380-6	2011	We have demonstrated that 3-6-fold lower amounts of the catalytic subunit of human and bovine enteropeptidase is required for 95% cleavage of Trx/TRAIL and Trx/FGF-2 fusions with (Asp)(4)-Arg cleavage sequence in comparison to native sequence (Asp)(4)-Lys.	Arginine	188-191	thioredoxin	Bos taurus	142-145
21856937-4	2011	In this article, we define the three-dimensional structure of the complex between the HR (arginine, R134) allele of FcgammaRIIa (FcgammaRIIa-HR) and the Fc region of a humanized IgG1 Ab, hu3S193.	Arginine	90-98	Fc gamma receptor IIa	Homo sapiens	116-127
21856937-4	2011	In this article, we define the three-dimensional structure of the complex between the HR (arginine, R134) allele of FcgammaRIIa (FcgammaRIIa-HR) and the Fc region of a humanized IgG1 Ab, hu3S193.	Arginine	90-98	Fc gamma receptor IIa	Homo sapiens	129-140
21917714-4	2011	Here, we show that protein arginine methylation limits the ERK1/2 signal elicited by particular growth factors in different cell types from various species.	Arginine	27-35	mitogen activated protein kinase 3	Rattus norvegicus	59-65
22100794-5	2011	In HLA-E*0101 it is arginine and in HLA-E*0103 it is glycine.	Arginine	20-28	major histocompatibility complex, class I, E	Homo sapiens	3-8
23785515-7	2013	The adaptive changes in liver function were accompanied by an increased expression of genes involved in arginine metabolism (Asl, Got1, Gpt2, Glud1, Arg1, and Arg2) and transport (Slc25a13, Slc25a15, and Slc3a2), whereas no such changes were found in the intestine.	Arginine	104-112	arginase, liver	Mus musculus	149-153
23599269-5	2013	RNA-binding domain 4 and the glycine/arginine-rich domain of nucleolin were essential for its association with Fas.	Arginine	37-45	nucleolin	Homo sapiens	61-70
21808053-6	2011	The TREX1 residues Arg-174 and Lys-175 positioned adjacent to the active sites act with the Arg-128 residues positioned in the catalytic cores to facilitate melting of dsDNA and generate ssDNA for entry into the active sites.	Arginine	19-22	three prime repair exonuclease 1	Homo sapiens	4-9
21808053-6	2011	The TREX1 residues Arg-174 and Lys-175 positioned adjacent to the active sites act with the Arg-128 residues positioned in the catalytic cores to facilitate melting of dsDNA and generate ssDNA for entry into the active sites.	Arginine	92-95	three prime repair exonuclease 1	Homo sapiens	4-9
21586312-7	2011	The mutagenesis of His269 and Leu267 of AKR1B14 into the corresponding residues (Arg and Pro, respectively) of AKR1B7 resulted in low and pH-independent activation by bile acids.	Arginine	81-84	aldo-keto reductase family 1, member B7	Rattus norvegicus	40-47
21586312-7	2011	The mutagenesis of His269 and Leu267 of AKR1B14 into the corresponding residues (Arg and Pro, respectively) of AKR1B7 resulted in low and pH-independent activation by bile acids.	Arginine	81-84	aldo-keto reductase family 1, member B7	Rattus norvegicus	111-117
21538481-9	2011	The N-terminal sequences of the 14-kDa fragment were identified as Leu-Arg-Ala-Pro-Ser-Trp-Phe, indicating that this fragment is generated by cleavage at Phe54-Leu55 of alphaB-crystallin.	Arginine	71-74	crystallin, alpha B	Rattus norvegicus	169-186
23529130-9	2013	Overexpression of T487A caused significant reduction of endogenous TRPC6-like current induced by Arg(8)-vasopressin in A7r5 aortic myocytes.	Arginine	97-100	transient receptor potential cation channel subfamily C member 6	Homo sapiens	67-72
21620933-5	2011	Normally, an RNA editing step changes DNA-encoded glutamine to arginine, introduces arginine in the GluR2 pore apex.	Arginine	63-71	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	100-105
21872570-3	2011	Interestingly, the Kir channels do not have this exact interaction, but instead have a Glu-Arg salt bridge where the Glu is in the same position but the Arg is one position N-terminal compared to the Asp in KcsA.	Arginine	91-94	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	19-22
21872570-3	2011	Interestingly, the Kir channels do not have this exact interaction, but instead have a Glu-Arg salt bridge where the Glu is in the same position but the Arg is one position N-terminal compared to the Asp in KcsA.	Arginine	153-156	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	19-22
23782684-2	2013	IDH mutations are specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 or arginine 172 residue (R172) of IDH2 in gliomas.	Arginine	89-97	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	159-163
21620933-5	2011	Normally, an RNA editing step changes DNA-encoded glutamine to arginine, introduces arginine in the GluR2 pore apex.	Arginine	84-92	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	100-105
23782684-2	2013	IDH mutations are specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 or arginine 172 residue (R172) of IDH2 in gliomas.	Arginine	128-136	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	159-163
21775527-3	2011	Therefore, we hypothesized that l-arginine, a substrate for iNOS, is acted upon by arginase-I (Arg-I), contributing to the resolution of inflammation.	Arginine	32-42	arginase, liver	Mus musculus	83-93
21728354-2	2011	The protein kinase SRPK1 phosphorylates ~10 serines in the arginine--serine-rich domain (RS domain) of the SR protein SRSF1 in a C- to N-terminal direction, a modification that directs this essential splicing factor from the cytoplasm to the nucleus.	Arginine	59-67	SRSF protein kinase 1	Homo sapiens	19-24
23617808-5	2013	Our NMR data, combined with precipitation assays, show that there are additional SNARE complex/synaptotagmin-1 interactions that lead to aggregation and that involve in part two arginines at the bottom of the C2B domain.	Arginine	178-187	synaptotagmin 1	Homo sapiens	95-110
21728354-2	2011	The protein kinase SRPK1 phosphorylates ~10 serines in the arginine--serine-rich domain (RS domain) of the SR protein SRSF1 in a C- to N-terminal direction, a modification that directs this essential splicing factor from the cytoplasm to the nucleus.	Arginine	59-67	RNA binding protein with serine rich domain 1	Homo sapiens	107-117
21775527-3	2011	Therefore, we hypothesized that l-arginine, a substrate for iNOS, is acted upon by arginase-I (Arg-I), contributing to the resolution of inflammation.	Arginine	32-42	arginase, liver	Mus musculus	95-100
23560482-6	2013	Substantial production of NH2Cl from l-arginine and l-histidine was observed at Cl/P = 1.0 and 2.0 when post-chlorination was applied to UV254-irradiated samples.	Arginine	37-47	cleavage factor polyribonucleotide kinase subunit 1	Homo sapiens	80-88
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Arginine	146-149	NADH kinase	Saccharomyces cerevisiae S288C	71-75
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Arginine	146-149	NADH kinase	Saccharomyces cerevisiae S288C	157-161
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Arginine	89-92	NADH kinase	Saccharomyces cerevisiae S288C	232-236
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Arginine	285-288	NADH kinase	Saccharomyces cerevisiae S288C	232-236
21730068-7	2011	Arg-293 and Ser-272 were highly conserved in Pos5 homologs (putative NADH kinases), but not in putative NAD kinases.	Arginine	0-3	NADH kinase	Saccharomyces cerevisiae S288C	45-49
21730068-8	2011	Thus, Arg-293 of Pos5 is a major determinant of NADH selectivity.	Arginine	6-9	NADH kinase	Saccharomyces cerevisiae S288C	17-21
21700716-0	2011	Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4.	Arginine	8-16	programmed cell death 4	Homo sapiens	110-133
21763278-12	2011	Mutations at Arg-73 and Arg-76, but not Lys-79, prevented pro-BNP processing.	Arginine	13-16	natriuretic peptide B	Homo sapiens	62-65
21763278-12	2011	Mutations at Arg-73 and Arg-76, but not Lys-79, prevented pro-BNP processing.	Arginine	24-27	natriuretic peptide B	Homo sapiens	62-65
23486913-0	2013	Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	0-8	ribosomal protein S6	Sus scrofa	105-109
23486913-0	2013	Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway.	Arginine	0-8	eukaryotic translation initiation factor 4E binding protein 1	Sus scrofa	116-124
21586431-2	2011	The purpose of this study was to investigate how the aromatic/arginine (ar/R) selectivity filter influences the substrate selectivity of two NIP aquaporins; the silicic acid (Si) transporter OsLsi1 (OsNIP2;1) from rice and the boric acid (B) transporter AtNIP5;1 from Arabidopsis; both proteins are also permeable to arsenite.	Arginine	62-70	NOD26-like intrinsic protein 5;1	Arabidopsis thaliana	254-262
21626661-2	2011	A number of studies demonstrated that arginine-conjugated chitosan (CS)/DNA nanoparticles (ACGN) mediated significantly higher expression of the transgenes when compared with CS/DNA nanoparticles (CGN).	Arginine	38-46	cingulin	Homo sapiens	92-95
23395770-6	2013	cDNA analysis of alpha-globin genes revealed a normal alpha1-globin gene sequence and a CCG (Pro) to CGG (Arg) mutation at codon 95 of the alpha2-globin gene leading to the Hb St.Luke"s-Thailand or Hb St. Luke"s [A2] HBA2: c.287C&gt;G. DNA analysis of the patient and his mother identified the in cis alpha-globin gene triplication.	Arginine	106-109	hemoglobin subunit alpha 2	Homo sapiens	17-29
21626661-5	2011	The data accumulated in the current study revealed that conjugation of arginine moieties onto CS molecules enhanced the cellular uptake of the polymer/DNA nanoparticles and their transgenic efficacy, probably due to changes in the endocytic pathways, which led to the preference of internalization of ACGN by the caveolin-mediated endocytosis in comparison with that of CGN.	Arginine	71-79	cingulin	Homo sapiens	302-305
21565207-2	2011	In this paper, we aimed to investigate whether the entire MafA protein has the self-delivery activity, and that the arginine- and lysine-rich sequence in MafA bZIP domain is an efficient protein transduction domain (PTD).	Arginine	116-124	MAF bZIP transcription factor A	Rattus norvegicus	58-62
21565207-2	2011	In this paper, we aimed to investigate whether the entire MafA protein has the self-delivery activity, and that the arginine- and lysine-rich sequence in MafA bZIP domain is an efficient protein transduction domain (PTD).	Arginine	116-124	MAF bZIP transcription factor A	Rattus norvegicus	154-158
21402151-3	2011	TRPC7 contains three putative cGK phosphorylation sites (Arg-Arg/Lys-Xaa-Ser/Thr).	Arginine	57-60	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	0-5
21402151-3	2011	TRPC7 contains three putative cGK phosphorylation sites (Arg-Arg/Lys-Xaa-Ser/Thr).	Arginine	61-64	transient receptor potential cation channel, subfamily C, member 7	Mus musculus	0-5
21622724-2	2011	Furthermore, a germ line polymorphism in the FGFR-4 gene, resulting in arginine at codon 388 (Arg388) instead of glycine (Gly388), is associated with aggressive disease.	Arginine	71-79	fibroblast growth factor receptor 4	Homo sapiens	45-51
21652632-0	2011	Arginine methylation of G3BP1 in response to Wnt3a regulates beta-catenin mRNA.	Arginine	0-8	Wnt family member 3A	Homo sapiens	45-50
21585196-4	2011	The resulting chelate-Rev (EDTA-Rev, DTPA-Rev, NTA-Rev, and DOTA-Rev) conjugates were used to form coordination complexes with Fe(2+), Co(2+), Ni(2+), and Cu(2+) such that the arginine-rich Rev peptide could mediate localization of the metal chelates to the Rev peptide"s high-affinity mRNA binding partner, RRE stem loop IIB.	Arginine	176-184	Rev	Human immunodeficiency virus 1	22-25
21489986-3	2011	These changes create a hydrophobic pocket in COX-2, with Arg-513 located at the base of the pocket, which has been exploited in the design of COX-2-selective inhibitors.	Arginine	57-60	cytochrome c oxidase II, mitochondrial	Mus musculus	45-50
21489986-3	2011	These changes create a hydrophobic pocket in COX-2, with Arg-513 located at the base of the pocket, which has been exploited in the design of COX-2-selective inhibitors.	Arginine	57-60	cytochrome c oxidase II, mitochondrial	Mus musculus	142-147
21351738-8	2011	Mutation of the Arg residue to Ala in the Drosophila Polyhomeotic (Ph) protein, which is equivalent to Lys 816 in HPH1, was unable to repress transcription of a reporter gene to the level of wild-type Ph.	Arginine	16-19	polyhomeotic distal	Drosophila melanogaster	67-69
21642970-1	2011	We have determined the solution structure of the complex between an arginine-glycine-rich RGG peptide from the human fragile X mental retardation protein (FMRP) and an in vitro-selected guanine-rich (G-rich) sc1 RNA.	Arginine	68-76	transcription factor 19	Homo sapiens	208-211
21642987-4	2011	IFIT1 bound PPP-RNA with nanomolar affinity and required the arginine at position 187 in a highly charged carboxy-terminal groove of the protein.	Arginine	61-69	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	0-5
21293034-9	2011	Interestingly, GCH1 mRNA levels increased in response to Arg treatment.	Arginine	57-60	GTP cyclohydrolase 1	Homo sapiens	15-19
21293034-10	2011	Importantly, Arg, Leu, Gln, and glucose increased the abundance of phosphorylated MTOR, RPS6K, RPS6, and EIF4EBP1 proteins as well as NOS and ODC1 proteins, but only Arg increased the abundance of IFNT protein.	Arginine	13-16	ribosomal protein S6	Homo sapiens	88-92
21293034-10	2011	Importantly, Arg, Leu, Gln, and glucose increased the abundance of phosphorylated MTOR, RPS6K, RPS6, and EIF4EBP1 proteins as well as NOS and ODC1 proteins, but only Arg increased the abundance of IFNT protein.	Arginine	13-16	ornithine decarboxylase 1	Homo sapiens	142-146
21293034-12	2011	Increases in abundance of IFNT protein (the pregnancy recognition signal), NOS2, NOS3 and GCH1 for conversion of Arg to nitric oxide, and ODC1 for synthesis of polyamines are all important for growth and development of the ovine conceptus during pregnancy.	Arginine	113-116	GTP cyclohydrolase 1	Homo sapiens	90-94
21294109-2	2011	Many of these comprise the exclusive combination of a classic, catalytic Arg-containing RhoGAP domain, and a Cdc42/ Rac interactive binding (CRIB) motif which in animal and fungi has been identified in effectors for Cdc42 and Rac1, but never in any GAP protein.	Arginine	73-76	cell division cycle 42	Homo sapiens	216-221
21626217-8	2011	For those with baseline LV dysfunction, being homozygous for Arg at amino acid position 389 in beta1-AR was associated with decreases in ESV (-46 mL, CI -3.1, -88) and EDV (-40 mL, CI -1.1, -79) and an increase in LVEF (11%, CI 0.3, 22).	Arginine	61-64	adrenoceptor beta 1	Homo sapiens	95-103
20460353-6	2011	We found a nonsense mutation of C to T at nucleotide 202 in exon 9, resulting in a transition of arginine to stop codon, and in 1 child, we found a timine deletion in exon 4 in ERGIC-53 gene.	Arginine	97-105	lectin, mannose binding 1	Homo sapiens	177-185
21107779-7	2011	The concentration of L-Arg was significantly higher in ghrelin-treated rats than in control while arginase activity was significantly lower in ghrelin-treated than in control hearts.	Arginine	21-26	ghrelin and obestatin prepropeptide	Rattus norvegicus	55-62
21330347-1	2011	ARG1, expressed by human PMNs, inhibits T cell proliferation by depleting extracellular L-arginine.	Arginine	88-98	arginase 1	Homo sapiens	0-4
20619625-8	2011	Dietary Arg supplementation increased mRNA levels for fatty acid synthase in muscle, while decreasing those for lipoprotein lipase, glucose transporter-4, and acetyl-coenzyme A carboxylase-alpha in adipose tissue.	Arginine	8-11	fatty acid synthase	Sus scrofa	54-73
21478268-6	2011	Wnt3a also increased the expression of a subset of endogenous Wnt target genes, and CARM1 was required for the Wnt-induced expression of these target genes and the accompanying dimethylation of arginine 17 of histone H3.	Arginine	194-202	Wnt family member 3A	Homo sapiens	0-5
21405950-1	2011	The arginine-rich cationic Tat peptides have been reported to enhance the intracellular delivery of macromolecules, including DNA, RNA, and proteins.	Arginine	4-12	tyrosine aminotransferase	Homo sapiens	27-30
21338328-2	2011	It is formed from L-arginine by NOS isoforms (nNOS, iNOS and eNOS).	Arginine	18-28	nitric oxide synthase 1	Homo sapiens	46-50
21244633-3	2011	Here we show that the Arg-Gly-Gly (RGG) domain of the C-terminal in EWS binds to the G-rich single-stranded DNA and RNA fold in the G-quadruplex structure.	Arginine	22-25	EWS RNA binding protein 1	Homo sapiens	68-71
21244633-6	2011	These findings suggest that the RGG of EWS binds to G-quadruplex DNA and RNA via the Arg residues in it.	Arginine	85-88	EWS RNA binding protein 1	Homo sapiens	39-42
21262773-0	2011	Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.	Arginine	0-8	nuclear receptor subfamily 0 group B member 2	Homo sapiens	115-140
21262773-3	2011	We now show that the activity of SHP is also increased by posttranslational methylation at Arg-57 by protein arginine methyltransferase 5 (PRMT5).	Arginine	91-94	nuclear receptor subfamily 0 group B member 2	Homo sapiens	33-36
21039601-2	2011	In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine.	Arginine	155-165	nitric oxide synthase 1	Homo sapiens	79-83
21039601-2	2011	In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine.	Arginine	155-165	arginase 1	Homo sapiens	128-132
20735257-3	2011	Agmatine, an endogenous primary amine and a novel neuromodulator synthesized from the decarboxylation of l-arginine catalyzed by arginine decarboxylase (ADC), has been reported to possess neuroprotective properties.	Arginine	105-115	antizyme inhibitor 2	Mus musculus	129-151
20735257-3	2011	Agmatine, an endogenous primary amine and a novel neuromodulator synthesized from the decarboxylation of l-arginine catalyzed by arginine decarboxylase (ADC), has been reported to possess neuroprotective properties.	Arginine	105-115	antizyme inhibitor 2	Mus musculus	153-156
21743476-8	2011	A structural comparison of the CENP-A and H3 nucleosomes revealed that CENP-A contains two extra amino acid residues (Arg 80 and Gly 81) in the loop 1 region, which is completely exposed to the solvent.	Arginine	118-121	centromere protein A	Homo sapiens	71-77
21729333-6	2011	RESULTS: This analysis and two new crystal structures suggest that Ire1 RNase uses histidine H1061 and tyrosine Y1043 as the general acid-general base pair contributing &gt;=7.6 kcal/mol and 1.4 kcal/mol to transition state stabilization, respectively, and asparagine N1057 and arginine R1056 for coordination of the scissile phosphate.	Arginine	278-286	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	67-71
21453345-3	2011	LHT1 mutants displayed reduced uptake rates of L-Gln, L-Ala, L-Glu and L-Asp but not of L-Arg or L-Lys, while AAP5 mutants were affected in the uptake of L-Arg and L-Lys only.	Arginine	154-159	lysine histidine transporter 1	Arabidopsis thaliana	0-4
21585399-3	2011	AAMs exert their activity in part via the enzyme arginase-1 (Arg1), which hydrolyses L-arginine into urea and ornithine, and can supply precursor substrate for proline and polyamine production.	Arginine	85-95	arginase, liver	Mus musculus	61-65
21561100-2	2011	The UVR8 amino acid sequence contains a very high amount of conserved tryptophans, and the homology model shows that seven of these tryptophans cluster at the "top surface" of the UVR8 protein where they are intermixed with positive residues (mainly arginines) and a couple of tyrosines.	Arginine	250-259	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	4-8
21561100-2	2011	The UVR8 amino acid sequence contains a very high amount of conserved tryptophans, and the homology model shows that seven of these tryptophans cluster at the "top surface" of the UVR8 protein where they are intermixed with positive residues (mainly arginines) and a couple of tyrosines.	Arginine	250-259	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	180-184
21531728-5	2011	Arg-1203 was critical for binding to both porin (Por) B.1A and PorB.1B strains.	Arginine	0-3	voltage dependent anion channel 1	Homo sapiens	42-47
21531728-5	2011	Arg-1203 was critical for binding to both porin (Por) B.1A and PorB.1B strains.	Arginine	0-3	voltage dependent anion channel 1	Homo sapiens	49-52
21474449-6	2011	Nucleolin contains a long (~300 amino acids) intrinsically unstructured region, followed by the four tandem RNA recognition motifs and the C-terminal glycine/arginine-rich domain.	Arginine	158-166	nucleolin	Homo sapiens	0-9
21561087-3	2011	We recently reported that the Arg-Gly-Gly repeat (RGG) of the C-terminus in Ewing"s sarcoma protein (EWS), which is a group of dominant oncogenes that arise due to chromosomal translocations, is capable of binding to G-quadruplex telomere DNA and RNA via arginine residues and stabilize the G-quadruplex DNA form in vitro.	Arginine	30-33	EWS RNA binding protein 1	Homo sapiens	101-104
21561087-3	2011	We recently reported that the Arg-Gly-Gly repeat (RGG) of the C-terminus in Ewing"s sarcoma protein (EWS), which is a group of dominant oncogenes that arise due to chromosomal translocations, is capable of binding to G-quadruplex telomere DNA and RNA via arginine residues and stabilize the G-quadruplex DNA form in vitro.	Arginine	255-263	EWS RNA binding protein 1	Homo sapiens	101-104
21561087-7	2011	Our findings indicate that the RGG and the other arginine-rich motif of residues 617-656 of the RGG in EWS are important for the specific binding to G-quadruplex DNA.	Arginine	49-57	EWS RNA binding protein 1	Homo sapiens	103-106
21563828-3	2011	In this study, we demonstrate that purified recombinant human ADAM17 is able to cleave a 20-amino acid peptide mimetic corresponding to the extracellular juxtamembrane region of human ACE2 between Arg(708) and Ser(709).	Arginine	197-200	angiotensin converting enzyme 2	Homo sapiens	184-188
21563828-7	2011	In summary, we have demonstrated that ADAM17 is able to cleave ACE2 peptide sequence analogues between Arg(708) and Ser(709).	Arginine	103-106	angiotensin converting enzyme 2	Homo sapiens	63-67
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	34-37	angiotensin converting enzyme 2	Homo sapiens	109-113
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	47-50	angiotensin converting enzyme 2	Homo sapiens	109-113
21548565-10	2011	However, for NT(1-8), a greater preferential interaction between the guanidine group of Arg(8) and the roughened silver substrate was observed in comparison to that between the guanidine moiety of the other investigated peptides and the substrate.	Arginine	88-91	3'-nucleotidase	Homo sapiens	13-19
21342520-6	2011	For example, one-base shift to the left brings arginine codons CGN, with CG at 1-2 positions, to the respective anticodons NCG, with CG at 2-3 positions.	Arginine	47-55	cingulin	Homo sapiens	63-66
23395770-6	2013	cDNA analysis of alpha-globin genes revealed a normal alpha1-globin gene sequence and a CCG (Pro) to CGG (Arg) mutation at codon 95 of the alpha2-globin gene leading to the Hb St.Luke"s-Thailand or Hb St. Luke"s [A2] HBA2: c.287C&gt;G. DNA analysis of the patient and his mother identified the in cis alpha-globin gene triplication.	Arginine	106-109	hemoglobin subunit alpha 2	Homo sapiens	139-152
24048792-9	2011	Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes.	Arginine	89-97	Fc gamma receptor IIa	Homo sapiens	39-44
23525231-4	2013	HELZ2 interacts with the serine/arginine-rich domain and Bcl2 associated transcription factor1-homologous region in THRAP3, whereas THRAP3 directly binds 2 helicase motifs in HELZ2.	Arginine	32-40	thyroid hormone receptor associated protein 3	Mus musculus	116-122
24048792-9	2011	Patients who were heterozygous for the CD32a (Fcgamma receptor IIa) 131 histidine (H) to arginine (R) polymorphism had a significantly decreased PFS (P = .009) after R-bortezomib compared with HH and RR homozygotes.	Arginine	89-97	Fc gamma receptor IIa	Homo sapiens	46-66
21349258-5	2011	The OR for patients having the BHMT Arg/Gln or Gln/Gln genotypes was 0.579 (95% CI=0.3622-0.924; p=0.0216).	Arginine	36-39	betaine--homocysteine S-methyltransferase	Homo sapiens	31-35
21282648-4	2011	To elucidate the biological role of this process, we substituted LAT lysines with arginines.	Arginine	82-91	linker for activation of T cells	Homo sapiens	65-68
21147780-3	2011	Ex vivo data showed that human PCSK9 is inactivated by cleavage at Arg(218)  by the overexpressed convertases furin and PC5/6A.	Arginine	67-70	furin, paired basic amino acid cleaving enzyme	Homo sapiens	110-115
23434137-3	2013	On the other hand, while peptides with guanidino groups exhibited a similar tendency with respect to the peptide structure and thermal stability of RNA/RNA duplexes, those with longer side chain lengths, such as L-2-amino-4-guanidinobutyric acid (Agb) or L-arginine (Arg) oligomers, stabilized both RNA/RNA and DNA/DNA duplexes, and those with shorter side chain lengths exhibited a higher ability to selectively stabilize RNA/RNA duplexes.	Arginine	255-265	immunoglobulin kappa variable 3-15	Homo sapiens	212-215
21147780-3	2011	Ex vivo data showed that human PCSK9 is inactivated by cleavage at Arg(218)  by the overexpressed convertases furin and PC5/6A.	Arginine	67-70	proprotein convertase subtilisin/kexin type 5	Homo sapiens	120-126
21147780-5	2011	To identify the convertase(s) responsible for cleavage at Arg(218) in vivo, we inactivated the genes of furin and/or PC5/6 specifically in hepatocytes.	Arginine	58-61	furin (paired basic amino acid cleaving enzyme)	Mus musculus	104-109
21193457-13	2011	It was shown that arginine induced expression of Bcl-2 and Bcl-xL, while rReg4 upregulated Bcl-2 and Bcl-xL expression by activating the EGFR/Akt pathway.	Arginine	18-26	BCL2-like 1	Mus musculus	59-65
21321020-0	2011	A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.	Arginine	15-23	RAD9 checkpoint clamp component A	Homo sapiens	39-43
23434137-3	2013	On the other hand, while peptides with guanidino groups exhibited a similar tendency with respect to the peptide structure and thermal stability of RNA/RNA duplexes, those with longer side chain lengths, such as L-2-amino-4-guanidinobutyric acid (Agb) or L-arginine (Arg) oligomers, stabilized both RNA/RNA and DNA/DNA duplexes, and those with shorter side chain lengths exhibited a higher ability to selectively stabilize RNA/RNA duplexes.	Arginine	267-270	immunoglobulin kappa variable 3-15	Homo sapiens	212-215
21321020-5	2011	Arginine methylation of Rad9 plays a critical role in S/M and G2/M cell cycle checkpoints.	Arginine	0-8	RAD9 checkpoint clamp component A	Homo sapiens	24-28
23325127-5	2013	The base substitutions change a glycine to arginine in the fibronectin type 3 domain of nephrin and a proline to arginine in a conserved proline-rich region in Neph3.	Arginine	43-51	NPHS1 adhesion molecule, nephrin	Canis lupus familiaris	88-95
21321020-8	2011	In summary, we uncovered that arginine methylation is important for regulation of Rad9 function, and thus is a major element for maintaining genome integrity.	Arginine	30-38	RAD9 checkpoint clamp component A	Homo sapiens	82-86
21136528-1	2011	Arginase (EC 3.5.3.1) catalyzes the hydrolysis of arginine to ornithine and urea.	Arginine	50-58	arginase	Bombyx mori	0-8
23430259-3	2013	Here we demonstrate that another pair of basic residues (Arg(310)-Arg(311)) in the membrane-proximal region of the C-terminal tail plays a pivotal role in mediating the anterograde trafficking of GPR15.	Arginine	57-60	G protein-coupled receptor 15	Homo sapiens	196-201
21154234-7	2011	Treatment with L-arginine or SMT showed a significant reduction in CCl4-induced expression of these pro-fibrogenic factors, TNF-alpha and COX-2.	Arginine	15-25	prostaglandin-endoperoxide synthase 2	Mus musculus	138-143
21273489-2	2011	We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325.	Arginine	217-225	MALT1 paracaspase	Homo sapiens	29-34
21501661-9	2011	Genetic analysis revealed a nucleotide substitution in exon 7 of PSEN1 gene, producing a missense mutation in codon 235 from leucine amino acid to arginine (L235R).	Arginine	147-155	presenilin 1	Homo sapiens	65-70
21454547-6	2011	Furthermore, substitution of the first arginine led to hyperphosphorylation and accumulation of A-RAF and C-RAF in plasma membrane fraction, indicating that this residue interferes with the recycling process of A-RAF and C-RAF but not B-RAF.	Arginine	39-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	106-111
21454547-6	2011	Furthermore, substitution of the first arginine led to hyperphosphorylation and accumulation of A-RAF and C-RAF in plasma membrane fraction, indicating that this residue interferes with the recycling process of A-RAF and C-RAF but not B-RAF.	Arginine	39-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	221-226
21454547-8	2011	The exchange of the second arginine led to exceedingly increased dimerization as long as one of the protomers was not mutated, suggesting that substitution of this residue with alanine may result in similar a structural rearrangement of the RAF kinase domain, as has been found for the C-RAF kinase domain co-crystallized with a dimerization-stabilizing RAF inhibitor.	Arginine	27-35	zinc fingers and homeoboxes 2	Homo sapiens	241-244
23430259-3	2013	Here we demonstrate that another pair of basic residues (Arg(310)-Arg(311)) in the membrane-proximal region of the C-terminal tail plays a pivotal role in mediating the anterograde trafficking of GPR15.	Arginine	66-69	G protein-coupled receptor 15	Homo sapiens	196-201
21454547-8	2011	The exchange of the second arginine led to exceedingly increased dimerization as long as one of the protomers was not mutated, suggesting that substitution of this residue with alanine may result in similar a structural rearrangement of the RAF kinase domain, as has been found for the C-RAF kinase domain co-crystallized with a dimerization-stabilizing RAF inhibitor.	Arginine	27-35	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	286-291
21454547-8	2011	The exchange of the second arginine led to exceedingly increased dimerization as long as one of the protomers was not mutated, suggesting that substitution of this residue with alanine may result in similar a structural rearrangement of the RAF kinase domain, as has been found for the C-RAF kinase domain co-crystallized with a dimerization-stabilizing RAF inhibitor.	Arginine	27-35	zinc fingers and homeoboxes 2	Homo sapiens	288-291
23461848-10	2013	Both procaine and lidocaine significantly suppressed l-arginine uptake in BAEC stimulated with either bradykinin/acetylcholine or interleukin-1beta/lipopolysaccharide.	Arginine	53-63	interleukin 1 beta	Bos taurus	130-147
21184736-3	2011	HnRNP K is methylated at multiple sites in the glycine- and arginine-rich (RGG) motif.	Arginine	60-68	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	0-7
21184736-7	2011	Together our results identify preferred PRMT1 methylation sequences of hnRNP K by direct methylation assay and implicate a role of arginine methylation in regulating intracellular distribution of hnRNP K.	Arginine	131-139	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	196-203
25949116-5	2013	Since the up-regulated methylation levels of histone arginine residue lead to the maintenance of pluripotency in embryos and stem cells, it may be suggested that CARM1 overexpressing mESCs elevate the expression of pluripotency-related genes in reconstituted embryos for transgenic mice and may resist the differentiation into trophectoderm (TE).	Arginine	53-61	coactivator-associated arginine methyltransferase 1	Mus musculus	162-167
21283685-8	2011	Finally, we provide evidence that a single arginine residue of the C terminus of Pdx1 is responsible for coordinating co-operativity in this elaborate protein machinery.	Arginine	43-51	pancreatic and duodenal homeobox 1	Homo sapiens	81-85
21241251-6	2011	The distinct DNA-binding properties of TCP11 are due to the presence of a threonine residue at position 15 of the TCP domain, a position that is occupied by an arginine residue in most TCP proteins.	Arginine	160-168	TCP family transcription factor	Arabidopsis thaliana	39-44
22527286-4	2013	RESULTS: We found that the combined challenge of mast cells with pharmacological doses of arginine and glutamine caused a decrease in induced release of de novo synthesized leukotriene C(4) but not of pre-stored beta-hexosaminidase.	Arginine	90-98	O-GlcNAcase	Homo sapiens	212-231
20703835-2	2011	SC35 (also known as SFRS2 and PR264) is a member of this family and contains one RNA recognition motif (RRM domain) and a RS domain at the C-terminus which is enriched with arginine and serine residues.	Arginine	173-181	serine and arginine rich splicing factor 2	Homo sapiens	0-4
20703835-2	2011	SC35 (also known as SFRS2 and PR264) is a member of this family and contains one RNA recognition motif (RRM domain) and a RS domain at the C-terminus which is enriched with arginine and serine residues.	Arginine	173-181	serine and arginine rich splicing factor 2	Homo sapiens	20-25
20703835-2	2011	SC35 (also known as SFRS2 and PR264) is a member of this family and contains one RNA recognition motif (RRM domain) and a RS domain at the C-terminus which is enriched with arginine and serine residues.	Arginine	173-181	serine and arginine rich splicing factor 2	Homo sapiens	30-35
21454787-2	2011	Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1).	Arginine	63-71	coactivator-associated arginine methyltransferase 1	Mus musculus	87-138
21245169-2	2011	Here we show that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Arg 754 in the KIX region of coactivator p300.	Arginine	89-92	E1A binding protein p300	Homo sapiens	130-134
21245169-5	2011	This induction was severely attenuated by elimination of CARM1 or its methyltransferase activity, or by mutation of Arg 754 of p300.	Arginine	116-119	E1A binding protein p300	Homo sapiens	127-131
21245169-8	2011	Recruitment of BRCA1 to the p53-binding region of the p21 promoter in response to DNA damage required methylation of Arg 754 of p300 by CARM1.	Arginine	117-120	E1A binding protein p300	Homo sapiens	128-132
21454787-2	2011	Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the coactivator-associated arginine methyltransferase 1 (CARM1).	Arginine	63-71	coactivator-associated arginine methyltransferase 1	Mus musculus	140-145
23097400-11	2013	Arginine, His, and Leu are examples of AA that can promote insulin secretion, and in turn, insulin can increase fetal IGF-I concentrations.	Arginine	0-8	insulin-like growth factor I	Ovis aries	118-123
21217072-1	2011	Arginase 1, via competing with nitric oxide (NO) synthase for the substrate L-arginine, may interfere with NO-mediated vascular responses.	Arginine	76-86	arginase 1	Homo sapiens	0-10
21307606-5	2011	Moreover, we found novel DPL derivatives which were formed from xylose and such amino acids as alanine, arginine, aspartic acid, glutamic acid, isoleucine, leucine, phenylalanine, serine, and valine in the presence of lysine.	Arginine	104-112	prion like protein doppel	Homo sapiens	25-28
23365224-6	2013	Inhibiting RhoA prevents dendrite arbor loss following Arg knockdown in neurons, but does not block spine loss.	Arginine	55-58	ras homolog family member A	Mus musculus	11-15
20924721-3	2011	RESULT: A de novo missense mutation (c.2014C&gt;T with replacement C &gt; Y) in MYH3 gene leading to change of arginine at position 672 by cytosine in protein sequence.	Arginine	111-119	myosin heavy chain 3	Homo sapiens	80-84
21219670-8	2011	Compared with the control group, dietary supplementation with 1% L-arginine increased (P&lt;0 05) plasma concentrations of arginine and insulin (+36 %), and decreased (P&lt;0 05) plasma concentrations of cortisol (233 %), NH3 (221 %) and urea (219 %).	Arginine	65-75	insulin	Sus scrofa	136-143
21219670-8	2011	Compared with the control group, dietary supplementation with 1% L-arginine increased (P&lt;0 05) plasma concentrations of arginine and insulin (+36 %), and decreased (P&lt;0 05) plasma concentrations of cortisol (233 %), NH3 (221 %) and urea (219 %).	Arginine	67-75	insulin	Sus scrofa	136-143
23248265-7	2013	Furthermore, we noted that N(omega)-hydroxy-L-arginine or L-arginine, an arginase-1 inhibitor, blocked the reduction in MHC class II levels on CD11c(+) DC during the tumor-bearing state.	Arginine	44-54	arginase, liver	Mus musculus	73-83
21163358-1	2011	OBJECTIVE: To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury.	Arginine	157-160	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	23-34
21163358-1	2011	OBJECTIVE: To evaluate aggrecanase activity after traumatic knee injury in a rat model by measuring the level of aggrecanase-generated Ala-Arg-Gly-aggrecan (ARG-aggrecan) fragments in synovial fluid, and compare with ARG-aggrecan release into joint fluid following human knee injury.	Arginine	157-160	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	113-124
24453460-1	2011	Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO ) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding.	Arginine	46-56	nitric oxide synthase 1	Homo sapiens	99-129
24453460-1	2011	Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide (NO ) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding.	Arginine	46-56	nitric oxide synthase 1	Homo sapiens	131-135
23248265-7	2013	Furthermore, we noted that N(omega)-hydroxy-L-arginine or L-arginine, an arginase-1 inhibitor, blocked the reduction in MHC class II levels on CD11c(+) DC during the tumor-bearing state.	Arginine	44-54	integrin alpha X	Mus musculus	143-148
24371822-6	2013	The ADRB1 gene showed a statistically significant association with high-risk atherogenic index, OR = 2.94 (IC 95% 1.64-5.24; P &lt; 0.0001) for the Arg/Gly variant, under the dominant model an OR = 2.96 (IC 95% 1.67-5.25; P &lt; 0.0001), and under the Log additive model an OR = 2.52 (IC 95% 1.54-4.15; P &lt; 0.0001).	Arginine	148-151	adrenoceptor beta 1	Homo sapiens	4-9
21105165-1	2011	Previous studies showed that arginine-conjugated chitosan (ACS)/DNA nanoparticles (ACGN) mediated significantly higher expression of the transgenes when compared with chitosan (CS)/DNA nanoparticles (CGN).	Arginine	29-37	cingulin	Homo sapiens	84-87
21310339-1	2011	Argininemia is caused by a deficiency of arginase 1, which catalyzes the final step in the urea cycle, i.e., the cytosolic hydrolysis of arginine to ornithine and urea.	Arginine	137-145	arginase 1	Homo sapiens	41-51
21046201-0	2011	Enteral arginine modulates inhibition of AP-1/c-Jun by SP600125 in the postischemic gut.	Arginine	8-16	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-45
24397513-12	2013	Arginine addition decreased TG, cholesterol and A1-c haemoglobin concentration and increased PPARalpha, PPARgamma and iNOS expression.	Arginine	0-8	peroxisome proliferator-activated receptor gamma	Gallus gallus	104-113
21046201-1	2011	We previously demonstrated that enteral arginine increased c-Jun/activator protein-1 (AP-1) DNA-binding activity and iNOS expression in a rodent model of mesenteric ischemia/reperfusion (I/R).	Arginine	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-84
21046201-1	2011	We previously demonstrated that enteral arginine increased c-Jun/activator protein-1 (AP-1) DNA-binding activity and iNOS expression in a rodent model of mesenteric ischemia/reperfusion (I/R).	Arginine	40-48	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-90
21046201-2	2011	The objective of this study was to specifically investigate the role of AP-1 in arginine"s deleterious effect on the postischemic gut.	Arginine	80-88	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-76
21046201-3	2011	We hypothesized that AP-1 inhibition would mitigate the effects of arginine.	Arginine	67-75	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-25
21046201-9	2011	Our data suggest that AP-1 inhibition mitigates the injurious inflammatory effects of arginine in the postischemic gut.	Arginine	86-94	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-26
24124363-3	2013	In this study, we explore the preparation and characterization of gadolinium (Gd)-loaded poly (lactic-co-glycolic acid) (PLGA) particles surface modified with the Arg-Gly-Asp-Ser (RGDS) peptide for the detection of thrombus.	Arginine	163-166	ral guanine nucleotide dissociation stimulator	Homo sapiens	180-184
20647192-14	2011	In contrast, differential arginine methylation of yet unknown proteins by PRMT1 may be involved in the pathogenesis of acute and chronic rejection.	Arginine	26-34	protein arginine methyltransferase 1	Rattus norvegicus	74-79
23135270-2	2012	Another proprotein convertase, furin, cleaves PCSK9 at Arg(218)-Gln(219) in the surface-exposed "218 loop."	Arginine	55-58	furin (paired basic amino acid cleaving enzyme)	Mus musculus	31-36
23135270-7	2012	Further analysis by size exclusion chromatography and mass spectrometry indicated that furin and hepsin produced an internal cleavage in the 218 loop without the loss of the N-terminal segment (Ser(153)-Arg(218)), which remained attached to the catalytic domain.	Arginine	203-206	furin (paired basic amino acid cleaving enzyme)	Mus musculus	87-92
21686206-4	2011	The data in this report are derived from an analysis of variation in the CD23 gene that leads to a coding exchange and to a single nucleotide polymorphism (SNP) associated with the substitution of an arginine residue for a tryptophan residue in the protein structure of CD23.	Arginine	200-208	Fc epsilon receptor II	Homo sapiens	73-77
21686206-4	2011	The data in this report are derived from an analysis of variation in the CD23 gene that leads to a coding exchange and to a single nucleotide polymorphism (SNP) associated with the substitution of an arginine residue for a tryptophan residue in the protein structure of CD23.	Arginine	200-208	Fc epsilon receptor II	Homo sapiens	270-274
23099479-8	2012	Imatinib limited Arg-mediated endothelial barrier dysfunction by enhancing Rac1 activity and enforcing adhesion of endothelial cells to the extracellular matrix.	Arginine	17-20	Rac family small GTPase 1	Mus musculus	75-79
20966082-7	2010	Comparing the electrostatic surface potentials of the ECDs suggests a charge compatibility mechanism for ligand discrimination involving a single amino acid difference in the receptors (CRFR1 Glu104/CRFR2alpha Pro-100) at a site proximate to peptide residue 35 (Arg in CRF/Ucn1, Ala in Ucn2/3).	Arginine	262-265	corticotropin releasing hormone receptor 1	Homo sapiens	186-191
20966082-7	2010	Comparing the electrostatic surface potentials of the ECDs suggests a charge compatibility mechanism for ligand discrimination involving a single amino acid difference in the receptors (CRFR1 Glu104/CRFR2alpha Pro-100) at a site proximate to peptide residue 35 (Arg in CRF/Ucn1, Ala in Ucn2/3).	Arginine	262-265	urocortin 2	Homo sapiens	286-290
22824487-3	2012	The N-terminal sequences upstream of TGF-beta-type cysteine-knot domains in BMP-2, 7 and 14 contain the basic residues arginine and lysine, which are key components of the heparin/HS-binding sites, with these residues being highly non-conserved.	Arginine	119-127	bone morphogenetic protein 2	Homo sapiens	76-81
20807889-4	2010	Suppression was dependent on L-arginine depletion by arginase-1 activity.	Arginine	29-39	arginase 1	Homo sapiens	53-63
20807889-12	2010	In vivo administration of a pegylated form of human arginase-1 (PEG-arg1) resulted in L-arginine depletion and significant GVHD reduction.	Arginine	86-96	arginase 1	Homo sapiens	52-62
22441699-1	2012	This study was conducted to evaluate whether dietary supplementation with L-arginine (Arg) could attenuate Escherichia coli LPS-induced liver injury through the TLR4 signaling pathway in weaned pigs.	Arginine	74-84	toll like receptor 4	Sus scrofa	161-165
21043515-1	2010	The in vivo molecular imaging of nitric oxide synthase (NOS), the enzyme responsible for the catalytic oxidation of l-arginine to citrulline and nitric oxide (NO), by noninvasive modalities could provide valuable insights into NO/NOS-related diseases.	Arginine	116-126	nitric oxide synthase 1, neuronal	Mus musculus	33-54
22441699-1	2012	This study was conducted to evaluate whether dietary supplementation with L-arginine (Arg) could attenuate Escherichia coli LPS-induced liver injury through the TLR4 signaling pathway in weaned pigs.	Arginine	86-89	toll like receptor 4	Sus scrofa	161-165
20844967-8	2010	Associations between FGFR4 Gly388Arg polymorphism and overall survival exist in patients with gastric cancer (P = 0.046).The FGFR4 Arg allele (hazard risk (HR), 2.324; 95% confidence interval (CI), 1.054-4.125; P = 0.037) and TNM stage (HR, 5.516; 95% CI 3.658-7.409; P = 0.005) were independent prognostic factors in patients with gastric cancer.	Arginine	33-36	fibroblast growth factor receptor 4	Homo sapiens	21-26
22441699-8	2012	Additionally, it is possible that the protective effects of Arg on the liver are associated with a decreased release of liver pro-inflammatory cytokines and free radicals through inhibiting TLR4 signaling.	Arginine	60-63	toll like receptor 4	Sus scrofa	190-194
20844967-8	2010	Associations between FGFR4 Gly388Arg polymorphism and overall survival exist in patients with gastric cancer (P = 0.046).The FGFR4 Arg allele (hazard risk (HR), 2.324; 95% confidence interval (CI), 1.054-4.125; P = 0.037) and TNM stage (HR, 5.516; 95% CI 3.658-7.409; P = 0.005) were independent prognostic factors in patients with gastric cancer.	Arginine	33-36	fibroblast growth factor receptor 4	Homo sapiens	125-130
22495806-5	2012	Substitution of either K63 or K510 with arginine resulted in reduced SUMOylation for AhR.	Arginine	40-48	aryl hydrocarbon receptor	Homo sapiens	85-88
21157007-0	2010	Removal of the outermost arginine in IVS4 segment of the Ca(V)3.1 channel affects amplitude but not voltage dependence of gating current.	Arginine	25-33	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	57-65
23197718-1	2012	Serine-arginine protein kinases 2 (SRPK2) is a cell cycle-regulated kinase that phosphorylates serine/arginine domain-containing proteins and mediates pre-mRNA splicing with unclear function in neurons.	Arginine	7-15	serine/arginine-rich protein specific kinase 2	Mus musculus	35-40
20977208-2	2010	Numerous structure-activity relationship studies have identified Asp(1), Arg(2), and His(6) of Ang II to be critical for its biological activity and receptor binding.	Arginine	73-76	angiogenin	Homo sapiens	95-98
20977208-6	2010	It was followed by Arg-modified [Arg(2)(ONE-H(2)O)]-Ang II and the N-terminal-modified 4-ketoamide form of [N-ONE]-Ang II.	Arginine	19-22	angiogenin	Homo sapiens	52-55
20977208-6	2010	It was followed by Arg-modified [Arg(2)(ONE-H(2)O)]-Ang II and the N-terminal-modified 4-ketoamide form of [N-ONE]-Ang II.	Arginine	33-36	angiogenin	Homo sapiens	52-55
22971346-3	2012	The biologic analyses revealed an oncogenic importance for both polymorphic alleles, but FGFR4(gly) was the stronger inducer of tumor growth, whereas FGFR4(arg) was the stronger inducer of migration.	Arginine	156-159	fibroblast growth factor receptor 4	Homo sapiens	150-155
20977208-10	2010	tBoc-Arg readily reacted with ONE to produce a compound analogous to [Arg(2)(ONE-H(2)O)]-Ang II, which confirmed Arg as one of the important target nucleophiles of ONE.	Arginine	5-8	angiogenin	Homo sapiens	89-92
20977208-10	2010	tBoc-Arg readily reacted with ONE to produce a compound analogous to [Arg(2)(ONE-H(2)O)]-Ang II, which confirmed Arg as one of the important target nucleophiles of ONE.	Arginine	70-73	angiogenin	Homo sapiens	89-92
22971346-4	2012	An evaluation of clinical specimens revealed that FGFR4 was upregulated in 20/71 patients independent of gly(388)arg status.	Arginine	113-116	fibroblast growth factor receptor 4	Homo sapiens	50-55
23019216-5	2012	LPS stimulated l-arginine uptake, and this effect was blocked by the iNOS inhibitor 1400W.	Arginine	15-25	nitric oxide synthase 2	Canis lupus familiaris	69-73
20819953-5	2010	We observed that the conserved alphaH-alphaI loop residue Arg-283 in PrKX is crucial for its RI over RII preference, as a R283L mutant was able to form a holoenzyme complex with wild type RII subunits.	Arginine	58-61	protein kinase X-linked	Homo sapiens	69-73
22874569-5	2012	Silencing of ERN1 (IRE1alpha) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing, whereas led T lymphocytes to apoptosis under L-Arg starvation, suggesting that the ERN1-MAPK8 pathway plays a major role in the activation of autophagy following L-Arg depletion.	Arginine	181-186	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	13-17
21073746-12	2010	CONCLUSIONS: The relative position between the highly conserved GXXXG motif and an arginine residue around the gp41 MSD alpha-helix is critical for intracellular trafficking of HIV-1 Env.	Arginine	83-91	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	183-186
22874569-5	2012	Silencing of ERN1 (IRE1alpha) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing, whereas led T lymphocytes to apoptosis under L-Arg starvation, suggesting that the ERN1-MAPK8 pathway plays a major role in the activation of autophagy following L-Arg depletion.	Arginine	181-186	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	19-28
22874569-5	2012	Silencing of ERN1 (IRE1alpha) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing, whereas led T lymphocytes to apoptosis under L-Arg starvation, suggesting that the ERN1-MAPK8 pathway plays a major role in the activation of autophagy following L-Arg depletion.	Arginine	298-303	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	13-17
22874569-5	2012	Silencing of ERN1 (IRE1alpha) prevented the induction of autophagy as well as MAPK8 activation, BCL2 phosphorylation and XBP1 splicing, whereas led T lymphocytes to apoptosis under L-Arg starvation, suggesting that the ERN1-MAPK8 pathway plays a major role in the activation of autophagy following L-Arg depletion.	Arginine	298-303	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	19-28
22641416-0	2012	Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	17-19
20931971-1	2010	Three isoforms of nitric oxide synthase (NOS), dimeric enzymes that catalyze the formation of nitric oxide (NO) from arginine, have been identified.	Arginine	117-125	nitric oxide synthase 1, neuronal	Mus musculus	18-39
20428984-7	2010	Interestingly, we also noted the upregulation of arginine-rich, mutated in early stage of tumours (ARMET) and cysteine-rich with EGF-like domain protein 2 (CRELD2) are two genes that have only recently been implicated in the UPR.	Arginine	49-57	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	99-104
22641416-1	2012	The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression.	Arginine	25-28	gonadotropin releasing hormone receptor	Rattus norvegicus	62-76
22641416-1	2012	The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression.	Arginine	25-28	gonadotropin releasing hormone receptor	Rattus norvegicus	78-80
20626030-2	2010	The RP17 form of the disease is caused by an arginine to tryptophan (R14W) mutation in the signal sequence of carbonic anhydrase IV (CAIV).	Arginine	45-53	carbonic anhydrase 4	Homo sapiens	4-8
22641416-1	2012	The amino acid arginine (Arg) is a recognized secretagogue of growth hormone (GH), and has been shown to induce GH gene expression.	Arginine	25-28	gonadotropin releasing hormone receptor	Rattus norvegicus	112-114
20626030-2	2010	The RP17 form of the disease is caused by an arginine to tryptophan (R14W) mutation in the signal sequence of carbonic anhydrase IV (CAIV).	Arginine	45-53	carbonic anhydrase 4	Homo sapiens	110-131
20626030-2	2010	The RP17 form of the disease is caused by an arginine to tryptophan (R14W) mutation in the signal sequence of carbonic anhydrase IV (CAIV).	Arginine	45-53	carbonic anhydrase 4	Homo sapiens	133-137
22641416-2	2012	Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the effects of Arg, such as GH secretion.	Arginine	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	113-115
21316597-3	2011	(2011) demonstrate that these JAK2 mutants, but not wild-type JAK2, directly phosphorylate PRMT5 and inhibit its arginine methyltransferase activity, establishing a link between mutant JAK2 and histone arginine methylation.	Arginine	113-121	Janus kinase 2	Homo sapiens	30-34
22641416-2	2012	Arg is the natural precursor of nitric oxide (NO), which is known to mediate many of the effects of Arg, such as GH secretion.	Arginine	100-103	gonadotropin releasing hormone receptor	Rattus norvegicus	113-115
22641416-3	2012	Arg was also shown to increase calcium influx in pituitary cells, which might contribute to its effects on GH secretion.	Arginine	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	107-109
22641416-4	2012	Although the mechanisms involved in the effects of Arg on GH secretion are well established, little is known about them regarding the control of GH gene expression.	Arginine	51-54	gonadotropin releasing hormone receptor	Rattus norvegicus	58-60
20643479-2	2010	Here, we focused on integrin-mediated cell-scaffold adhesion and prepared cell adhesive fibroin in which a tandem repeat of the Arg-Gly-Asp-Ser (RGDS) sequence was genetically interfused in the fibroin light chain (L-chain) (L-RGDSx2 fibroin).	Arginine	128-131	ral guanine nucleotide dissociation stimulator	Homo sapiens	145-149
22641416-5	2012	We investigated whether the NO pathway and/or calcium are involved in the effects of Arg on GH gene expression in rat isolated pituitaries.	Arginine	85-88	gonadotropin releasing hormone receptor	Rattus norvegicus	92-94
22641416-8	2012	The NO acceptor hemoglobin (0.3 microM) blunted the effect of SNP, and the combined treatment with Arg and L-NAME (a NO synthase (NOS) inhibitor, 55 mM) abolished the stimulatory effect of Arg on GH gene expression.	Arginine	99-102	gonadotropin releasing hormone receptor	Rattus norvegicus	196-198
21112944-7	2011	Additionally, we investigated the effect of the peptide L-arginine-threonine-arginine (RTR), which binds to PGP sequences, on the smoke-induced neutrophil influx in the lung after 5 days of smoke exposure.	Arginine	56-66	nuclear receptor subfamily 6, group A, member 1	Mus musculus	87-90
22641416-9	2012	The calcium channel inhibitor nifedipine (3 microM) also abolished Arg-induced GH gene expression.	Arginine	67-70	gonadotropin releasing hormone receptor	Rattus norvegicus	79-81
22641416-10	2012	The present study shows that Arg directly induces GH gene expression in hemi-pituitaries isolated from rats, excluding interference from somatostatinergic neurons, which are supposed to be inhibited by Arg.	Arginine	29-32	gonadotropin releasing hormone receptor	Rattus norvegicus	50-52
19959491-2	2010	It was recently shown that thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and also fibrin-plasminogen interaction by the removal of lysine and arginine residues from fibrin monomers.	Arginine	171-179	carboxypeptidase B2	Homo sapiens	27-70
19959491-2	2010	It was recently shown that thrombin-activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and also fibrin-plasminogen interaction by the removal of lysine and arginine residues from fibrin monomers.	Arginine	171-179	carboxypeptidase B2	Homo sapiens	72-76
22641416-11	2012	Moreover, the data demonstrate that the NOS/NO signaling pathway and calcium mediate the Arg effects on GH gene expression.	Arginine	89-92	gonadotropin releasing hormone receptor	Rattus norvegicus	104-106
21115085-4	2011	In this study we demonstrate that a 3-day HA in the ammonium acetate model increases the expression in the brain of y(+)LAT2, the heteromeric transporter which preferentially stimulates Arg efflux from the cells in exchange for Gln.	Arginine	186-189	linker for activation of T cells family, member 2	Rattus norvegicus	120-124
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Arginine	75-83	arginase, liver	Mus musculus	48-58
21115085-5	2011	The expression of the basic amino acid transporter CAT1, transporting Arg but not Gln remained unaffected by HA.	Arginine	70-73	solute carrier family 7 member 1	Rattus norvegicus	51-55
21115085-6	2011	Multiple parameters of Arg or Gln uptake and/or efflux and their mutual dependence were altered in the cerebral cortical slices obtained from HA rats, in a manner indicating enhanced y(+)LAT2-mediated transport.	Arginine	23-26	linker for activation of T cells family, member 2	Rattus norvegicus	187-191
21115085-9	2011	The results suggest that, reduced delivery of Arg due to enhanced y(+)LAT2-mediated exchange of extracellular Gln for intracellular Arg may contribute to the decrease of NO/cGMP pathway activity evoked in the brain by HA.	Arginine	46-49	linker for activation of T cells family, member 2	Rattus norvegicus	70-74
21115085-9	2011	The results suggest that, reduced delivery of Arg due to enhanced y(+)LAT2-mediated exchange of extracellular Gln for intracellular Arg may contribute to the decrease of NO/cGMP pathway activity evoked in the brain by HA.	Arginine	132-135	linker for activation of T cells family, member 2	Rattus norvegicus	70-74
20449600-2	2010	Post-translational symmetrical dimethylation of arginines on the coilin RG-box is required for the recruitment of the survival motor neuron (SMN) protein and splicing small ribonucleoproteins (snRNPs) to CBs.	Arginine	48-57	coilin	Homo sapiens	65-71
23011410-4	2012	In the following, we provide a concise compendium of NMR characteristics of the main types of eukaryotic PTMs: serine, threonine, tyrosine and histidine phosphorylation, lysine acetylation, lysine and arginine methylation, and serine, threonine O-glycosylation.	Arginine	201-209	parathymosin	Homo sapiens	105-109
20810994-8	2010	The inhibitory effect of ISG15 or ISGylation on NS5A was efficiently blocked by substitution of lysine at 379 residue to arginine within the C-terminal region, suggesting that ISGylation directly controls protein stability of NS5A.	Arginine	121-129	ISG15 ubiquitin like modifier	Homo sapiens	25-30
21148395-5	2011	Here we demonstrate that rnr1 plants overaccumulate an antisense RNA, AS5, that is complementary to the 5S rRNA, its intergenic spacer, and the downstream trnR gene, which encodes tRNA(Arg), raising the possibility that AS5 destabilizes 5S rRNA or its precursor and/or blocks rRNA maturation.	Arginine	185-188	ribonucleotide reductase 1	Arabidopsis thaliana	25-29
20950587-9	2011	This is probably as a result of an Arg(29) residue, previously shown to be critical for muscle (alpha1)(2)betagammadelta nAChR affinity, and highly conserved across all short-chain, but not long-chain, alpha-neurotoxins.	Arginine	35-38	cholinergic receptor nicotinic beta 3 subunit	Gallus gallus	121-126
22269898-10	2012	High-dose arginine significantly increased spontaneous TNF-alpha, and Con A stimulated IL-4 and IL-6 in PBLs.	Arginine	10-18	interleukin 4	Rattus norvegicus	87-91
23146735-4	2012	RESULTS: A heterozygous 743G&gt;A mutation was found in the patient and his mother, resulting in the substitution of glycine (G) by arginine (R) in codon 222(G222R) in the putative membrane-spanning domain in human G6Pase, but not in his father and his sister.	Arginine	132-140	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	215-221
21853108-3	2011	Essential components of this complex have been localized to a minimal arginine rich Rev peptide and stem IIB region of RRE.	Arginine	70-78	Rev	Human immunodeficiency virus 1	84-87
20558222-10	2010	These results suggest that CAT1 is at least involved in [(3)H]l-arginine uptake by TR-MUL5 cells.	Arginine	62-72	solute carrier family 7 member 1	Rattus norvegicus	27-31
20558222-11	2010	In conclusion, GlyT1 and CAT1 most likely mediate glycine and L-arginine uptake, respectively, by Muller cells and are expected to play an important role in supplying precursors for creatine biosynthesis in Muller cells.	Arginine	62-72	solute carrier family 7 member 1	Rattus norvegicus	25-29
22922050-5	2012	An inactive modified fragment of PACAP38, i.e. [Arg(17)]PACAP(11-38), with preserved cell-penetrating physico-chemical properties, was also synthesized and successfully use for the intracellular delivery of various cargoes such as small molecules, peptides, proteins, and polynucleotides.	Arginine	48-51	adenylate cyclase activating polypeptide 1	Homo sapiens	33-38
20624383-8	2010	Selective pharmacological inhibition of nNOS with L-Arg(NO2)-L-Dbu-NH(2) 2TFA and specific knock-down of nNOS abrogated H(2)O(2) and decreased by half acetylcholine-induced vasodilation.	Arginine	50-55	nitric oxide synthase 1, neuronal	Mus musculus	40-44
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	alanyl aminopeptidase, membrane	Homo sapiens	55-71
21695060-9	2011	ADAM10 was found to cleave APLP2 after arginine 670, whereas BACE1 cleaves after leucine 659.	Arginine	39-47	ADAM metallopeptidase domain 10	Homo sapiens	0-6
21695060-9	2011	ADAM10 was found to cleave APLP2 after arginine 670, whereas BACE1 cleaves after leucine 659.	Arginine	39-47	amyloid beta precursor like protein 2	Homo sapiens	27-32
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	alanyl aminopeptidase, membrane	Homo sapiens	72-76
22922050-7	2012	Uptake mechanism studies demonstrated that direct translocation, caveolae-dependent endocytosis and macropinocytosis were involved in the internalization of [Arg(17)]PACAP(11-38).	Arginine	158-161	adenylate cyclase activating polypeptide 1	Homo sapiens	166-171
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Arginine	189-197	dynamin 3	Homo sapiens	69-78
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Arginine	106-109	DLG associated protein 4	Homo sapiens	77-82
20730478-1	2010	The arginine decarboxylase (ADC) is a significant functional enzyme, synthesizes agmatine through arginine metabolism, and agmatine was reported to posses protective properties in various tissues.	Arginine	4-12	antizyme inhibitor 2	Mus musculus	28-31
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	139-149	arginase, liver	Mus musculus	85-89
22885179-2	2012	MDSCs express two enzymes, i.e. inducible nitric oxide synthase (iNOS) and arginase (ARG1), which metabolize the semi-essential amino acid L-arginine (L-Arg) whose bioavailability is crucial for T-cell proliferation and functions.	Arginine	151-156	arginase, liver	Mus musculus	85-89
20736164-6	2010	These phenotypes require the central region of USP8, containing three extended Arg-X-X-Lys (RXXK) motifs that specify direct low affinity interactions with the SH3 domain(s) of ESCRT-0 proteins, STAM1/2.	Arginine	79-82	ubiquitin specific peptidase 8	Homo sapiens	47-51
22588130-7	2012	One missense mutation c.2909G>C on exon 21 of AGTPBP1 was discovered, which induces an Arg to Pro substitution (p.Arg970Pro) at amino-acid 970, a conserved residue for the catalytic activity of AGTPBP1.	Arginine	87-90	ATP/GTP binding protein 1	Mus musculus	46-53
20876349-5	2010	GzmK cleaves VCP at residue Arg(713) in the D2 domain and abrogates its ATPase activity.	Arginine	28-31	granzyme K	Homo sapiens	0-4
20876349-5	2010	GzmK cleaves VCP at residue Arg(713) in the D2 domain and abrogates its ATPase activity.	Arginine	28-31	valosin containing protein	Homo sapiens	13-16
20736162-5	2010	Similarly, during pancreas perfusions in BCATm(-/-) mice, glucose and arginine stimulated insulin release, whereas KICSIS was largely abolished.	Arginine	70-78	branched chain aminotransferase 2, mitochondrial	Mus musculus	41-46
22588130-7	2012	One missense mutation c.2909G>C on exon 21 of AGTPBP1 was discovered, which induces an Arg to Pro substitution (p.Arg970Pro) at amino-acid 970, a conserved residue for the catalytic activity of AGTPBP1.	Arginine	87-90	ATP/GTP binding protein 1	Mus musculus	194-201
22929836-7	2012	Nitric oxide (NO) synthase which comes in three isoforms, as inducible-, neuronal- and endothelial-NOS, or iNOS, nNOS or eNOS, respectively, catalyzes the conversion of L- arginine to L-citrulline, using NADPH to produce NO.	Arginine	169-180	nitric oxide synthase 1	Homo sapiens	113-117
20958962-4	2010	The recently discovered NR3 subunits feature an unprecedented glycine-arginine combination at those critical sites within the pore.	Arginine	70-78	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	24-27
20798359-4	2010	OBJECTIVE: To identify the potential role of STAT3 arginine methylation by PRMT2 in the regulation of leptin signaling and energy homeostasis.	Arginine	51-59	protein arginine N-methyltransferase 2	Mus musculus	75-80
20863361-8	2010	One patient had a heterozygous mutation leading to the substitution of arginine at residue 1530 of SUR1 (ABCC8) by cysteine.	Arginine	71-79	ATP binding cassette subfamily C member 8	Homo sapiens	99-103
20863361-8	2010	One patient had a heterozygous mutation leading to the substitution of arginine at residue 1530 of SUR1 (ABCC8) by cysteine.	Arginine	71-79	ATP binding cassette subfamily C member 8	Homo sapiens	105-110
22572871-8	2012	The nitrergic modulation of B31/B32 is likely to contribute to the control of feeding by dietary changes in the concentration of L: -arginine, the precursor from which NO is synthesized.	Arginine	129-141	cytohesin 1 interacting protein	Homo sapiens	28-31
20798359-10	2010	CONCLUSIONS: These data elucidate a molecular pathway that directly links arginine methylation of STAT3 by PRMT2 to the regulation of leptin signaling, suggesting a potential role for PRMT2 antagonism in the treatment of obesity and obesity-related syndromes.	Arginine	74-82	protein arginine N-methyltransferase 2	Mus musculus	107-112
20798359-10	2010	CONCLUSIONS: These data elucidate a molecular pathway that directly links arginine methylation of STAT3 by PRMT2 to the regulation of leptin signaling, suggesting a potential role for PRMT2 antagonism in the treatment of obesity and obesity-related syndromes.	Arginine	74-82	protein arginine N-methyltransferase 2	Mus musculus	184-189
20628049-11	2010	Indeed, alanine mutation of either Arg(445) (helix 8) or Asp(498) (helix 10) abrogated T(3) transport activity of MCT8, supporting their predicted role in substrate recognition.	Arginine	35-38	solute carrier family 16 member 2	Homo sapiens	114-118
22610453-2	2012	Substitution of Arg for the generally conserved Gly-193 has been implicated as a critical determinant of the unusual behavior of mesotrypsin toward protein protease inhibitors.	Arginine	16-19	serine protease 3	Homo sapiens	129-140
20804738-1	2010	The MALT1 paracaspase has arginine-directed proteolytic activity.	Arginine	26-34	MALT1 paracaspase	Homo sapiens	4-9
20804738-3	2010	Upon T- or B-cell receptor engagement human (h) A20 is cleaved by MALT1 after arginine 439, yielding an N-terminal fragment (hA20p50) and a C-terminal one (hA20p37).	Arginine	78-86	MALT1 paracaspase	Homo sapiens	66-71
20554524-5	2010	In addition, the SH2 domain of PTK6, particularly the Arg(105) residue that contacts the phosphate group of the tyrosine residue, was essential for the association.	Arginine	54-57	protein tyrosine kinase 6	Homo sapiens	31-35
22829704-3	2012	Integrin-ECM interaction was inhibited with anti-beta1-integrin monoclonal antibody (mAb) or RGDS (Arg-Gly-Asp-Ser).	Arginine	99-102	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	93-97
20620066-5	2010	The most active inhibitor with C-terminal Arg residue underwent detectable proteolysis action in the presence of 35pM of HAT.	Arginine	42-45	transmembrane serine protease 11D	Homo sapiens	121-124
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	Rho GTPase activating protein 35	Homo sapiens	37-47
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	Rho GTPase activating protein 35	Homo sapiens	37-41
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	RAS p21 protein activator 1	Homo sapiens	79-89
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	RAS p21 protein activator 1	Homo sapiens	79-83
20737438-8	2010	This p120:p190 colocalization redistributes to a more peripheral distribution in abl(-/-) cells and to a more centralized distribution in arg(-/-) cells, and these altered distributions can be restored to WT patterns via re-expression of Abl or Arg, respectively.	Arginine	138-141	RAS p21 protein activator 1	Homo sapiens	5-9
20737438-8	2010	This p120:p190 colocalization redistributes to a more peripheral distribution in abl(-/-) cells and to a more centralized distribution in arg(-/-) cells, and these altered distributions can be restored to WT patterns via re-expression of Abl or Arg, respectively.	Arginine	138-141	Rho GTPase activating protein 35	Homo sapiens	10-14
20737438-8	2010	This p120:p190 colocalization redistributes to a more peripheral distribution in abl(-/-) cells and to a more centralized distribution in arg(-/-) cells, and these altered distributions can be restored to WT patterns via re-expression of Abl or Arg, respectively.	Arginine	245-248	RAS p21 protein activator 1	Homo sapiens	5-9
20737438-8	2010	This p120:p190 colocalization redistributes to a more peripheral distribution in abl(-/-) cells and to a more centralized distribution in arg(-/-) cells, and these altered distributions can be restored to WT patterns via re-expression of Abl or Arg, respectively.	Arginine	245-248	Rho GTPase activating protein 35	Homo sapiens	10-14
21162995-7	2010	77-amino acid of Vpr protein had three polymorphism forms as Arginin, Glutamine and Histidine, with Glutamine as the wild form.	Arginine	61-68	Vpr	Human immunodeficiency virus 1	17-20
22447520-6	2012	Interestingly, we also discovered two unreported sequence variants in SPINT1 and SPINT2 in two tumors that resulted in Arginine to Histidine amino acid substitutions at codons 418 and 233, respectively.	Arginine	119-127	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	70-76
20676220-0	2010	An evolutionarily conserved arginine is essential for Tre1 G protein-coupled receptor function during germ cell migration in Drosophila melanogaster.	Arginine	28-36	Trapped in endoderm 1	Drosophila melanogaster	54-58
20551905-4	2010	A second motif proximal to the cNLS is a cluster of arginines that serves coatomer-mediated retrieval of SUN2 from the Golgi.	Arginine	52-61	Sad1 and UNC84 domain containing 2	Homo sapiens	105-109
20835242-4	2010	Here we report the crystal structures of the UBR boxes of the human N-recognins UBR1 and UBR2, alone and in complex with an N-end rule peptide, Arg-Ile-Phe-Ser.	Arginine	144-147	ubiquitin protein ligase E3 component n-recognin 2	Homo sapiens	89-93
20647382-7	2010	Our study provides a conclusive link between the well-described growth-regulating functions of arginine metabolism and the previously unknown specific physiological role of the NCAPG protein in mammalian metabolism.	Arginine	95-103	non-SMC condensin I complex subunit G	Homo sapiens	177-182
22411529-5	2012	The participation of the L-arginine/nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway in peripheral antinociception has been established by our group to the mu-, kappa- or delta-opioid receptor agonists, nonsteroidal analgesics, alpha(2C) -adrenoceptor agonists, and even nonpharmacological electroacupuncture.	Arginine	25-35	adrenoceptor alpha 2C	Rattus norvegicus	243-266
20639906-3	2010	Recently, we identified the SR (Ser-Rich/Arg) protein SC35, a splicing factor, as a new transcriptional target of E2F1.	Arginine	41-44	serine and arginine rich splicing factor 2	Homo sapiens	54-58
22440150-3	2012	Poly(acrylic acid) hydrogels were synthesized by UV polymerization and pendant MMP-2 sensitive peptides (Gly-Pro-Leu-Gly-Val-Arg-Gly-Lys) conjugated throughout using EDC/sulfo-NHS chemistry.	Arginine	125-128	matrix metallopeptidase 2	Homo sapiens	79-84
21433360-5	2010	The Clk family is known to alter the actions of the spliceosome by phosphorylating the serine-arginine rich (SR) proteins that are critical elements of spliceosome assembly.	Arginine	94-102	CDC like kinase 1	Homo sapiens	4-7
20553007-9	2010	Generated mutant uroporphyrinogen III decarboxylase variants carrying amino acid exchanges in the position of both arginine residues (R41A, R41K, R37A, and R37K) failed to produce coproporphyrinogen III.	Arginine	115-123	uroporphyrinogen decarboxylase	Homo sapiens	17-51
22615363-3	2012	Here we show that CENP-A from Saccharomyces cerevisiae, termed Cse4, is methylated on arginine 37 (R37) and that this methylation regulates the recruitment of kinetochore components to centromeric sequences.	Arginine	86-94	centromeric DNA-binding histone H3-like protein CSE4	Saccharomyces cerevisiae S288C	63-67
20382750-1	2010	The expression of arginase I has been a focus of research into the pathogenesis of experimental asthma, because arginase deprives nitric oxide synthase (NOS) of arginine and therefore participates in the attenuation of bronchodilators such as nitric oxide (NO).	Arginine	161-169	arginase, liver	Mus musculus	18-28
19481782-10	2010	The increased levels and activity of DDAH I and DDAH II enzymes following myocardial infarction suggest a potential role for them in local protection of NOS enzymes from inhibition by methylated arginines during infarct healing.	Arginine	195-204	dimethylarginine dimethylaminohydrolase 2	Rattus norvegicus	48-55
22324426-6	2012	The RRC1 polypeptide contains a C-terminal arginine/serine-rich (RS) domain that is important for the regulation of alternative splicing.	Arginine	43-51	RNA recognition motif (RRM)-containing protein	Arabidopsis thaliana	4-8
21212863-3	2010	We previously reported that agmatine, synthesized from L-arginine by arginine decarboxylase (ADC) which is expressed in endothelial cells, has shown a direct increased eNOS expression and decreased MMPs expression in bEnd3 cells.	Arginine	55-65	antizyme inhibitor 2	Mus musculus	69-91
20541591-8	2010	CONCLUSION: Protein arginine dimethylations of hnRNPR, CstF-64, and TPI were regulated during HeLa cell cycle by respective PRMTs.	Arginine	20-28	heterogeneous nuclear ribonucleoprotein R	Homo sapiens	47-53
20071141-5	2010	RESULTS: The productions of vascular endothelial growth factor, basic fibroblast growth factor, prostaglandin E(2), and matrix metalloproteinase-2 were higher with Arg 100 and 1000 micromol/L than with Arg 0 and 50 micromol/L Arg, and this was consistent with the expression of CD51/CD61 by ECs.	Arginine	164-167	matrix metallopeptidase 2	Homo sapiens	120-146
20071141-5	2010	RESULTS: The productions of vascular endothelial growth factor, basic fibroblast growth factor, prostaglandin E(2), and matrix metalloproteinase-2 were higher with Arg 100 and 1000 micromol/L than with Arg 0 and 50 micromol/L Arg, and this was consistent with the expression of CD51/CD61 by ECs.	Arginine	202-205	matrix metallopeptidase 2	Homo sapiens	120-146
20071141-5	2010	RESULTS: The productions of vascular endothelial growth factor, basic fibroblast growth factor, prostaglandin E(2), and matrix metalloproteinase-2 were higher with Arg 100 and 1000 micromol/L than with Arg 0 and 50 micromol/L Arg, and this was consistent with the expression of CD51/CD61 by ECs.	Arginine	202-205	matrix metallopeptidase 2	Homo sapiens	120-146
20541591-9	2010	GENERAL SIGNIFICANCE: These results suggest that regulation of arginine dimethylation of hnRNPR, CstF-64, and TPI at G0/G1 to G1 are most likely to modulate the cellular growth and proliferation in HeLa cell cycle.	Arginine	63-71	heterogeneous nuclear ribonucleoprotein R	Homo sapiens	89-95
22175298-3	2012	Intriguingly, supplementation of irradiated cells with L-arginine results in decreased production of peroxynitrite, suggesting that suppression of superoxide generation by nitric oxide synthase in one or more microenvironments is an important factor in the observed radioprotection.	Arginine	55-65	nitric oxide synthase 1, neuronal	Mus musculus	172-193
20580677-1	2010	Rev, a viral regulatory protein of HIV-1, binds through its arginine-rich domain to the Rev-responsive element (RRE), a secondary structure in transcribed HIV-1 RNA.	Arginine	60-68	Rev	Human immunodeficiency virus 1	0-3
20580677-1	2010	Rev, a viral regulatory protein of HIV-1, binds through its arginine-rich domain to the Rev-responsive element (RRE), a secondary structure in transcribed HIV-1 RNA.	Arginine	60-68	Rev	Human immunodeficiency virus 1	88-91
19447018-3	2010	The results showed that the production of vascular endothelial growth factor (VEGF), basic fibroblast growth factor with 100 and 1000 micromol/L Arg and matrix metalloproteinase (MMP)-2 with 1000 micromol/L Arg was lower than that with 0 and 50 micromol/L Arg.	Arginine	207-210	matrix metallopeptidase 2	Homo sapiens	153-185
19447018-3	2010	The results showed that the production of vascular endothelial growth factor (VEGF), basic fibroblast growth factor with 100 and 1000 micromol/L Arg and matrix metalloproteinase (MMP)-2 with 1000 micromol/L Arg was lower than that with 0 and 50 micromol/L Arg.	Arginine	207-210	matrix metallopeptidase 2	Homo sapiens	153-185
22937649-8	2012	The increase of arginine, ornithine, and methionine contents promoted the activities of polyamines synthesis enzymes, which led to the significant increase of polyamines contents and the significant decrease of DAO and PAO activities.	Arginine	16-24	amine oxidase copper containing 1	Homo sapiens	211-214
20452997-4	2010	This problematic trend is notably illustrated by two recent studies that classified the p.A121T PRSS1 variant as pancreatitis associated, in large part owing to its intimate proximity to arginine-122, the residue affected by the disease causing p.R122H mutation.	Arginine	187-195	serine protease 1	Homo sapiens	96-101
20560456-4	2010	Antibodies to citrullinated protein/peptide antigens, i.e., to peptides post-translationally modified by the conversion of arginine to cilrulline (ACPA), are specific serological markers for RA.	Arginine	123-131	proteinase 3	Homo sapiens	147-151
20638985-5	2010	PANDER secretion from alpha-cells is nutritionally and hormonally regulated by l-arginine and insulin, demonstrating similarities and differences with glucagon.	Arginine	79-89	FAM3 metabolism regulating signaling molecule B	Homo sapiens	0-6
20529840-3	2010	We investigated its importance in neuronal NOS (nNOS) by mutating the two residues that primarily create the bridging interaction (Arg(752) in the FMN subdomain and Glu(47) in CaM).	Arginine	131-134	nitric oxide synthase 1	Homo sapiens	48-52
20529840-6	2010	We conclude that the Arg(752)-Glu(47) bridging interaction is the main feature that enables CaM to activate nNOS.	Arginine	21-24	nitric oxide synthase 1	Homo sapiens	108-112
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Arginine	66-74	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
20691902-3	2010	We find that PRC1"s microtubule binding is mediated by a structured domain with a spectrin-fold and an unstructured Lys/Arg-rich domain.	Arginine	120-123	protein regulator of cytokinesis 1	Homo sapiens	13-17
22651890-6	2012	RESULTS: We found that mutations of either of the prolines or the arginine of PXXPXR are defective for Nef-Hck binding, Nef/activated PAK2 complex formation and enhancement of virion infectivity (EVI).	Arginine	66-74	p21 (RAC1) activated kinase 2	Homo sapiens	134-138
22483960-6	2012	Taking all of these findings into consideration, we postulate that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of neuroinflammation in EAE lesions, possibly through the reduction of nitric oxide in the lesion via competition with iNOS for the use of L-arginine.	Arginine	308-318	arginase 1	Rattus norvegicus	90-100
20661013-3	2010	Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea.	Arginine	91-99	arginase 1	Homo sapiens	0-10
20661013-3	2010	Arginase-1 (Arg-1) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of arginine to ornithine and urea.	Arginine	91-99	arginase 1	Homo sapiens	12-17
20101215-6	2010	To investigate whether furinase cleavage of CD109 is necessary for its biological activity, we mutated arginine 1273 in the CD109 furinase cleavage motif (amino acid 1270-RRRR-1273) to serine (R1273S).	Arginine	103-111	CD109 molecule	Homo sapiens	44-49
20101215-6	2010	To investigate whether furinase cleavage of CD109 is necessary for its biological activity, we mutated arginine 1273 in the CD109 furinase cleavage motif (amino acid 1270-RRRR-1273) to serine (R1273S).	Arginine	103-111	CD109 molecule	Homo sapiens	124-129
22452443-1	2012	The purpose of this study was to examine whether the structural modification on the positively charged Lys linker could reduce the kidney uptake of (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Arginine	164-167	pro-opiomelanocortin-alpha	Mus musculus	193-229
20154084-1	2010	Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a novel conserved Phe-Arg-Arg-Gly motif and function in autophagy-related pathways.	Arginine	107-110	WD repeat domain, phosphoinositide interacting 2	Homo sapiens	10-15
20150913-2	2010	This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3.	Arginine	50-53	galectin 3	Homo sapiens	88-92
22452443-1	2012	The purpose of this study was to examine whether the structural modification on the positively charged Lys linker could reduce the kidney uptake of (99m)Tc-labeled Arg-Gly-Asp (RGD)-conjugated alpha-melanocyte stimulating hormone (alpha-MSH) hybrid peptides.	Arginine	164-167	pro-opiomelanocortin-alpha	Mus musculus	231-240
20150913-3	2010	The SH (Src homology)3 domains of c-Abl/Arg bind to a P(80)GPPSGP motif of Gal3, and Tyr79 and Tyr118 are the major tyrosine phosphorylation sites.	Arginine	40-43	galectin 3	Homo sapiens	75-79
22345165-0	2012	Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes.	Arginine	0-8	cofilin 1	Homo sapiens	38-45
20430034-0	2010	Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.	Arginine	14-22	solute carrier family 7 member 2	Homo sapiens	110-114
20430034-4	2010	The results obtained demonstrate that the activation of PKCalpha by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.	Arginine	131-139	solute carrier family 7 member 2	Homo sapiens	201-207
20430034-4	2010	The results obtained demonstrate that the activation of PKCalpha by phorbol esters or thymeleatoxin causes a transient increase of arginine transport through system y(+), referable to the induction of SLC7A2 mRNAs and to the increased expression of CAT2 transporters.	Arginine	131-139	solute carrier family 7 member 2	Homo sapiens	249-253
20430034-5	2010	PKCalpha-dependent stimulation of arginine transport requires the activation of MEK/ERK1/2 cascade, which leads to the stimulation of AP-1 and to the consequent induction of CAT2 expression.	Arginine	34-42	solute carrier family 7 member 2	Homo sapiens	174-178
20614574-0	2010	Discrepancy in factor VIII 1-stage/2-stage activity in a child with Arg(531)--&gt; His mutation.	Arginine	68-71	coagulation factor VIII	Homo sapiens	15-26
20167924-4	2010	The insertion allele disrupted binding of metal-regulatory transcription factor 1, which resulted in significant reduction of in vitro DDAH1 transcriptional activity and in vivo DDAH1 mRNA level, and in turn, increased plasma ADMA level and the ratio of ADMA to L-arginine.	Arginine	262-272	metal regulatory transcription factor 1	Homo sapiens	42-81
19669080-8	2010	Consistent with the data on cell growth and protein turnover, addition of 100 or 350 microM Arg to culture medium increased relative protein levels for phosphorylated mTOR and phosphorylated ribosomal protein S6 kinase-1, while reducing the relative levels of TLR4 and phosphorylated levels of nuclear factor-kappaB in LPS-treated IPEC-1 cells.	Arginine	92-95	toll like receptor 4	Sus scrofa	260-264
19669080-9	2010	These results demonstrate a protective effect of Arg against LPS-induced enterocyte damage through mechanisms involving mTOR and TLR4 signaling pathways, as well as intracellular protein turnover.	Arginine	49-52	toll like receptor 4	Sus scrofa	129-133
22345165-9	2012	Finally, we show that impaired cofilin dephosphorylation is also detectable in human T cells activated in a granulocyte-dominated purulent micromilieu due to arginase-mediated arginine depletion.	Arginine	176-184	cofilin 1	Homo sapiens	31-38
20948559-3	2010	Only the Arg389Gly polymorphism of the beta(1)-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7).	Arginine	9-12	adrenoceptor beta 1	Homo sapiens	39-66
20643302-3	2010	Recent data led to the identification of a novel mechanism of T cell suppression caused by the depletion of arginine through the induction of arginase 1 (ARG1) in a specialized group of immature myeloid cells, now named myeloid-derived suppressor cells (MDSC).	Arginine	108-116	arginase 1	Homo sapiens	142-152
20643302-3	2010	Recent data led to the identification of a novel mechanism of T cell suppression caused by the depletion of arginine through the induction of arginase 1 (ARG1) in a specialized group of immature myeloid cells, now named myeloid-derived suppressor cells (MDSC).	Arginine	108-116	arginase 1	Homo sapiens	154-158
20948559-3	2010	Only the Arg389Gly polymorphism of the beta(1)-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7).	Arginine	146-149	adrenoceptor beta 1	Homo sapiens	39-66
20948559-3	2010	Only the Arg389Gly polymorphism of the beta(1)-adrenergic receptor gene was associated with increased risk for mild OSA in hypertensive patients (Arg/Arg versus Gly/Arg/Gly/Gly, 2.1, 95% CI, 1.02-4.7).	Arginine	146-149	adrenoceptor beta 1	Homo sapiens	39-66
22374868-5	2012	Site-directed mutagenesis of the LZ-GCN4 RNA binding interface showed that substrate binding is facilitated by lysine and arginine side chains, and that at least one nucleophilic residue is located in proximity to the RNA phosphate backbone.	Arginine	122-130	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	36-40
19965803-5	2010	The presence of an arginine instead of a histidine residue at amino acid position 131 (H131R) in the extracellular domain of FcgammaRIIa reduces the affinity of the receptor for IgG(2) and IgG(3) isotypes but increases the binding activity for C reactive protein (CRP).	Arginine	19-27	Fc gamma receptor IIa	Homo sapiens	125-136
22614839-6	2012	Multiple arginine residues of RAP55A were indeed asymmetrically dimethylated in the cell and PRMT1 was shown to be a component of large mRNP granules induced by RAP55A overexpression.	Arginine	9-17	LSM14A mRNA processing body assembly factor	Homo sapiens	30-36
20080973-0	2010	Arginine methylation of vasa protein is conserved across phyla.	Arginine	0-8	vasa	Drosophila melanogaster	24-28
22455313-1	2012	Thrombin-catalyzed activation of factor VIII (FVIII) occurs through proteolysis at three P1 Arg residues: Arg(372) and Arg(740) in the FVIII heavy chain and Arg(1689) in the FVIII light chain.	Arginine	92-95	coagulation factor VIII	Homo sapiens	33-44
22334663-7	2012	Nucleosomes in which these lysines are replaced with arginines are resistant to such structural changes, and arginine mutants prevent the eviction of H2A and dissociation of polyubiquitinated DDB2 from UV-damaged nucleosomes.	Arginine	53-62	damage specific DNA binding protein 2	Homo sapiens	192-196
20026073-6	2010	We find that arginine 120 plays a significant role in modulating the pK(a) of the C-terminal active-site cysteine in the a domain of PDI and plays a role in determining the reactivity of the N-terminal active-site cysteine but not via direct modulation of its pK(a).	Arginine	13-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	133-136
20026073-7	2010	Mutation of arginine 120 and the corresponding residue, arginine 461, in the a" domain severely reduces the ability of PDI to catalyze disulfide bond formation and reduction but enhances the ability to catalyze disulfide bond isomerization due to the formation of more stable PDI-substrate mixed disulfides.	Arginine	12-20	prolyl 4-hydroxylase subunit beta	Homo sapiens	119-122
22120531-2	2012	MANF, also referred to as arginine rich, mutated in early stage of tumors (Armet), was identified as an endoplasmic reticulum (ER) stress-inducible factor.	Arginine	26-34	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	0-4
20026073-7	2010	Mutation of arginine 120 and the corresponding residue, arginine 461, in the a" domain severely reduces the ability of PDI to catalyze disulfide bond formation and reduction but enhances the ability to catalyze disulfide bond isomerization due to the formation of more stable PDI-substrate mixed disulfides.	Arginine	12-20	prolyl 4-hydroxylase subunit beta	Homo sapiens	276-279
20026073-7	2010	Mutation of arginine 120 and the corresponding residue, arginine 461, in the a" domain severely reduces the ability of PDI to catalyze disulfide bond formation and reduction but enhances the ability to catalyze disulfide bond isomerization due to the formation of more stable PDI-substrate mixed disulfides.	Arginine	56-64	prolyl 4-hydroxylase subunit beta	Homo sapiens	119-122
20026073-7	2010	Mutation of arginine 120 and the corresponding residue, arginine 461, in the a" domain severely reduces the ability of PDI to catalyze disulfide bond formation and reduction but enhances the ability to catalyze disulfide bond isomerization due to the formation of more stable PDI-substrate mixed disulfides.	Arginine	56-64	prolyl 4-hydroxylase subunit beta	Homo sapiens	276-279
20026073-8	2010	These results suggest that the modulation of pK(a) of the C-terminal active cysteine by the movement of the side chain of these arginine residues into the active-site locales has evolved to allow PDI to efficiently catalyze both oxidation and isomerization reactions.	Arginine	128-136	prolyl 4-hydroxylase subunit beta	Homo sapiens	196-199
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Arginine	55-58	Rho family GTPase 1	Homo sapiens	0-4
19936946-8	2010	Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer.	Arginine	120-123	transcobalamin 2	Homo sapiens	111-115
22277655-9	2012	The appropriate spacing of the C-terminal Nox4 sequence may cooperate with a discrete arginine-based interaction site in the B-loop, providing an intrinsically active interface that could not be disrupted by peptides derived from the Nox4 C-terminus.	Arginine	86-94	NADPH oxidase 4	Homo sapiens	42-46
19936946-8	2010	Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer.	Arginine	124-127	transcobalamin 2	Homo sapiens	111-115
19863350-1	2010	This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk.	Arginine	147-150	sulfotransferase family 1A member 1	Homo sapiens	139-146
22277655-9	2012	The appropriate spacing of the C-terminal Nox4 sequence may cooperate with a discrete arginine-based interaction site in the B-loop, providing an intrinsically active interface that could not be disrupted by peptides derived from the Nox4 C-terminus.	Arginine	86-94	NADPH oxidase 4	Homo sapiens	234-238
22021003-5	2012	Deletion analyses of Zranb2 indicated that the serine/arginine-rich (SR) domain and the glutamine-rich domain were required for the inhibition of BMP activity and the interaction with Smad1, respectively.	Arginine	54-62	zinc finger RANBP2-type containing 2	Homo sapiens	21-27
20522245-9	2010	C-peptide and insulin responses to arginine and glucose were also higher in GT-KO animals.	Arginine	35-43	insulin	Sus scrofa	14-21
22226999-3	2012	Adenosine deaminase acting on RNA 2 (ADAR2) specifically mediates RNA editing at the glutamine/arginine (Q/R) site of GluA2 and motor neurons expressing Q/R site-unedited GluA2 undergo slow death in conditional ADAR2 knockout mice.	Arginine	95-103	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	118-123
20140093-7	2010	This Arg substitution prevents diphthamide biosynthesis at His715, rendering the mutated eEF-2 non-responsive to ADP-ribosylating toxins, while having no apparent effect on protein synthesis.	Arginine	5-8	elongation factor 2	Cricetulus griseus	89-94
22188168-1	2012	Arabidopsis possesses two arginase-encoding genes, ARGAH1 and ARGAH2, catalysing the catabolism of arginine into ornithine and urea.	Arginine	99-107	Arginase/deacetylase superfamily protein	Arabidopsis thaliana	62-68
22239978-11	2012	In addition, both Rb1 and Rg1 induce nitric oxide (NO) generation through increasing the phosphorylation of eNOS, activating Na+-independent l-arginine transport, and stimulating cationic amino acid transport (CAT)-1 mRNA expression in cultured endothelial cells.	Arginine	141-151	protein phosphatase 1, regulatory subunit 3A	Mus musculus	26-29
20052987-7	2010	In this work to elucidate the catalytic role of Arg15, a strictly conserved active site residue in class alpha GSTs, we analyzed the activation energy barrier and structural details associated with the GSTA1-1 mutants R15A, R15Repsilon,eta-c (an Arg residue with the epsilon,eta-nitrogens substituted by carbons), and R15Rneutral (a neutral Arg residue due to the a addition of a hydride in the zeta-carbon).	Arginine	48-51	glutathione S-transferase alpha 1	Homo sapiens	111-115
20052987-7	2010	In this work to elucidate the catalytic role of Arg15, a strictly conserved active site residue in class alpha GSTs, we analyzed the activation energy barrier and structural details associated with the GSTA1-1 mutants R15A, R15Repsilon,eta-c (an Arg residue with the epsilon,eta-nitrogens substituted by carbons), and R15Rneutral (a neutral Arg residue due to the a addition of a hydride in the zeta-carbon).	Arginine	48-51	glutathione S-transferase alpha 1	Homo sapiens	202-209
22388820-7	2012	Our structural and biochemical analyses identify the molecular mechanism for UVR8-mediated ultraviolet-B perception, in which ultraviolet-B radiation results in destabilization of the intramolecular cation-pi interactions, causing disruption of the critical intermolecular hydrogen bonds mediated by Arg 286 and Arg 338 and subsequent dissociation of the UVR8 homodimer.	Arginine	300-303	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	77-81
22388820-7	2012	Our structural and biochemical analyses identify the molecular mechanism for UVR8-mediated ultraviolet-B perception, in which ultraviolet-B radiation results in destabilization of the intramolecular cation-pi interactions, causing disruption of the critical intermolecular hydrogen bonds mediated by Arg 286 and Arg 338 and subsequent dissociation of the UVR8 homodimer.	Arginine	312-315	Regulator of chromosome condensation (RCC1) family protein	Arabidopsis thaliana	77-81
19843630-0	2010	Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats.	Arginine	7-15	solute carrier family 7 member 1	Rattus norvegicus	82-87
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	41-44	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	134-137
19843630-2	2010	We aimed to explore whether aging alters aortic arginine uptake by CAT-1, the selective arginine supplier to eNOS in rats.	Arginine	48-56	solute carrier family 7 member 1	Rattus norvegicus	67-72
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	41-44	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	170-178
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	41-44	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	179-182
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	53-56	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	134-137
20090832-8	2010	An arginine residue at this position however, as found for example in MICA or ULBP3, would cause steric clashes with UL16 residues.	Arginine	3-11	MHC class I polypeptide-related sequence A	Homo sapiens	70-74
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	53-56	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	170-178
22184126-11	2012	In contrast, replacing Arg(82), but not Arg(93), substantially reduces the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays a general role in substrate recognition, whereas Arg(93) specifically functions in NCAM recognition.	Arginine	23-26	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	86-94
22184126-11	2012	In contrast, replacing Arg(82), but not Arg(93), substantially reduces the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays a general role in substrate recognition, whereas Arg(93) specifically functions in NCAM recognition.	Arginine	23-26	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	95-98
22242898-5	2012	HepG2 cells were easily immobilized on the arginine-glycine-aspartic acid-serine (RGDS)-multiwalled carbon nanotubes (RGDS-MWCNTs) nanocomposite by the specific combination of RGD domains with integrin receptors on the cell surface.	Arginine	43-51	ral guanine nucleotide dissociation stimulator	Homo sapiens	82-86
21222265-3	2010	alpha-Melanocyte stimulating hormone is a tridecapeptide, with the core sequence His(6)-Phe(7)-Arg(8)-Trp(9) shared with beta- and gamma-MSH and identified as essential for receptor activation and stimulation of pigmentation.	Arginine	95-98	pro-opiomelanocortin-alpha	Mus musculus	0-36
19833888-8	2010	The THADA gene variant was associated with lower beta-cell response to GLP-1 and arginine (both P &lt; 1.6 x 10(-3)), suggesting lower beta-cell mass as a possible pathogenic mechanism.	Arginine	81-89	THADA armadillo repeat containing	Homo sapiens	4-9
22242898-5	2012	HepG2 cells were easily immobilized on the arginine-glycine-aspartic acid-serine (RGDS)-multiwalled carbon nanotubes (RGDS-MWCNTs) nanocomposite by the specific combination of RGD domains with integrin receptors on the cell surface.	Arginine	43-51	ral guanine nucleotide dissociation stimulator	Homo sapiens	118-122
19936667-5	2010	TSHB gene sequencing revealed a homozygous missense mutation due to single base substitution G?A at codon 85 resulting in change from Glycine to Arginine.	Arginine	145-153	thyroid stimulating hormone subunit beta	Homo sapiens	0-4
22179613-4	2012	The major arginine methylation site in LANA was mapped to arginine 20.	Arginine	10-18	LANA	Human gammaherpesvirus 8	39-43
22179613-4	2012	The major arginine methylation site in LANA was mapped to arginine 20.	Arginine	58-66	LANA	Human gammaherpesvirus 8	39-43
20144152-7	2010	patients with LV hypertrophy had higher frequency of genotype Arg/Arg of polymorphic maker Gly398Arg of ADRB1 gene (=0.008.	Arginine	62-65	adrenoceptor beta 1	Homo sapiens	104-109
22179613-10	2012	These results suggest that residue 20 is important for modulation of a subset of LANA functions and properties of this residue, including the hydrophobic character induced by arginine methylation, may contribute to the observed effects.	Arginine	175-183	LANA	Human gammaherpesvirus 8	81-85
20144152-7	2010	patients with LV hypertrophy had higher frequency of genotype Arg/Arg of polymorphic maker Gly398Arg of ADRB1 gene (=0.008.	Arginine	66-69	adrenoceptor beta 1	Homo sapiens	104-109
22215673-6	2012	The carboxyl-terminal di-arginine motif (Arg-186 and Arg-187) was shown to play an essential role in the binding of Cdc42 to PIP(2)-containing membranes.	Arginine	53-56	prolactin induced protein	Mus musculus	125-128
20144152-10	2010	At conduction of multifactorial analysis independently connected with increase of LV myocardial mass turned out age of patients, level of systolic arterial pressure, presence of excessive body mass and carriage of Arg/Arg genotype of polymorphic marker Gly389Arg of ADRB1 gene.	Arginine	214-217	adrenoceptor beta 1	Homo sapiens	266-271
20144152-10	2010	At conduction of multifactorial analysis independently connected with increase of LV myocardial mass turned out age of patients, level of systolic arterial pressure, presence of excessive body mass and carriage of Arg/Arg genotype of polymorphic marker Gly389Arg of ADRB1 gene.	Arginine	218-221	adrenoceptor beta 1	Homo sapiens	266-271
19800904-1	2010	Arginase1 and nitric oxide synthase2 (NOS2) utilize l-arginine as a substrate, with both enzymes expressed at high levels in the asthmatic lung.	Arginine	52-62	arginase, liver	Mus musculus	0-9
20576117-1	2010	BACKGROUND: Arginine is an amino acid that serves as a substrate for the enzymes nitric oxide synthase (NOS) and arginase, leading to synthesis of NO and ornithine, respectively.	Arginine	12-20	nitric oxide synthase 1, neuronal	Mus musculus	81-102
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Arginine	19-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	98-103
22103682-7	2012	We further demonstrate that the C-terminal glycine-arginine rich domain of nucleolin serves as the predominant binding domain for direct interaction with p53.	Arginine	51-59	nucleolin	Homo sapiens	75-84
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Arginine	19-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	143-148
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Arginine	19-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	149-152
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Arginine	19-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	143-148
20382164-6	2010	However, lysine to arginine mutations of the identified SUMO acceptor sites drastically inhibited LEDGF SUMOylation, extended the half-life of LEDGF/p75, and significantly increased its transcriptional activity on the heat shock protein 27 promoter, indicating a negative effect of SUMOylation on the transcriptional activity of LEDGF/p75.	Arginine	19-27	PC4 and SFRS1 interacting protein 1	Homo sapiens	335-338
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	153-156	E1A binding protein p300	Homo sapiens	327-331
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	165-168	E1A binding protein p300	Homo sapiens	327-331
22103682-9	2012	Conversely, the adjacent glycine-arginine rich domain of nucleolin interacted with p53 causing a modest stimulatory effect on p53 ubiquitination.	Arginine	33-41	nucleolin	Homo sapiens	57-66
20213214-2	2010	Here we have developed a novel strategy to pattern cells using a hyaluronic acid hydrogel material and photocaged RGDS (Arg-Gly-Asp-Ser) peptides.	Arginine	120-123	ral guanine nucleotide dissociation stimulator	Homo sapiens	114-118
21573951-4	2012	Positively charged aa such as arginine and lysine encoded by AAR or AGR (CGN) (R means A or G) are seen more frequently in X4 strains suggesting our hypothesis that a switch from R5 to X4 strains occurs via a G-to-A mutation.	Arginine	30-38	cingulin	Homo sapiens	73-76
19801664-5	2009	Five amino acids known to be critical for rat FAAH activity are also conserved in AtFAAH (Lys-205, Ser-281, Ser-282, Ser-305, and Arg-307).	Arginine	130-133	fatty-acid amide hydrolase-like	Rattus norvegicus	46-50
19801664-5	2009	Five amino acids known to be critical for rat FAAH activity are also conserved in AtFAAH (Lys-205, Ser-281, Ser-282, Ser-305, and Arg-307).	Arginine	130-133	fatty acid amide hydrolase	Arabidopsis thaliana	82-88
20508808-14	2010	Interestingly the residue Arg has been frequently implicated in four missense (R15C, R15S, R37S, and R59H) and in one truncation mutation (R140X) of CRYGD.	Arginine	26-29	crystallin gamma D	Homo sapiens	149-154
22056783-6	2012	Both arginine and leucine act individually and additively to propagate signals that are dependent on the activity of the mammalian target of rapamycin complex 1 (mTORC1).	Arginine	5-13	CREB regulated transcription coactivator 1	Mus musculus	162-168
20486090-4	2010	This mutation leads to an amino acid change of arginine to cysteine in the extracellular domain of ectodysplasin-A, a protein encoded by the EDA gene.	Arginine	47-55	ectodysplasin A	Homo sapiens	99-114
20486090-4	2010	This mutation leads to an amino acid change of arginine to cysteine in the extracellular domain of ectodysplasin-A, a protein encoded by the EDA gene.	Arginine	47-55	ectodysplasin A	Homo sapiens	141-144
19833728-4	2009	Substitutions were made in the DW-motif (Asp-382 and Trp-383) and its interacting residues (Tyr-145 and Arg-149) in the other subunit of PDK2 homodimer.	Arginine	104-107	pyruvate dehydrogenase kinase 2	Homo sapiens	137-141
19919057-2	2009	A lactam bridge-cyclized alpha-MSH peptide, DOTA-GlyGlu-CycMSH {DOTA-Gly-Glu-c[Lys-Nle-Glu-His-DPhe-Arg-Trp-Gly-Arg-Pro-Val-Asp]}, was synthesized and radiolabeled with 67Ga.	Arginine	100-103	pro-opiomelanocortin-alpha	Mus musculus	25-34
22517293-1	2012	BACKGROUND/AIMS: We aimed to discover if L-arginine and selenium alone or together can increase the effect of a hypocaloric diet enriched in legumes (HDEL) on central obesity and cardiovascular risk factors in women with central obesity.	Arginine	41-51	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	150-154
19808671-9	2009	Exemplary testing of hnRNP A1 revealed a critical role of arginine residues within the RGG box for interaction with Rev.	Arginine	58-66	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	21-29
20363638-2	2010	Based on the minimal four amino acid sequence of peptidic ligands known to bind NRP-1, we describe here the design, synthesis and biological evaluation of series of original sugar-based peptidomimetics using a C-glycosyl compound, derived from d-gulonolactone, as a scaffold, which was functionalized with side chains of the amino-acids arginine, and tryptophane or threonine.	Arginine	337-345	neuropilin 1	Homo sapiens	80-85
19808671-9	2009	Exemplary testing of hnRNP A1 revealed a critical role of arginine residues within the RGG box for interaction with Rev.	Arginine	58-66	Rev	Human immunodeficiency virus 1	116-119
20458182-0	2010	A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.	Arginine	12-20	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	40-46
22056509-0	2012	Phosphorylation of the arginine/serine repeats of lamin B receptor by SRPK1-insights from molecular dynamics simulations.	Arginine	23-31	SRSF protein kinase 1	Homo sapiens	70-75
22056509-1	2012	BACKGROUND: Arginine/serine (RS) repeats are found in several proteins in metazoans with a wide variety of functions, many of which are regulated by SR protein kinase 1 (SRPK1)-mediated phosphorylation.	Arginine	12-20	SRSF protein kinase 1	Homo sapiens	149-168
20491809-10	2010	This is the first report of ND resulting from mutation at arginine position 41 of Norrin.	Arginine	58-66	norrin cystine knot growth factor NDP	Homo sapiens	82-88
22056509-1	2012	BACKGROUND: Arginine/serine (RS) repeats are found in several proteins in metazoans with a wide variety of functions, many of which are regulated by SR protein kinase 1 (SRPK1)-mediated phosphorylation.	Arginine	12-20	SRSF protein kinase 1	Homo sapiens	170-175
23275711-4	2012	The docking simulation revealed that GA possibly inhibits functions of HMGB1 interfering with Lys(90), Arg(91), Ser(101), Tyr(149), C(230) and C(231) in the HMGB1-DNA complex.	Arginine	103-106	high mobility group box 1	Homo sapiens	71-76
20100836-0	2010	An arginine stretch limits ADAM10 exit from the endoplasmic reticulum.	Arginine	3-11	ADAM metallopeptidase domain 10	Homo sapiens	27-33
20100836-5	2010	Sequential deletion/mutagenesis analyses showed that an arginine-rich ((723)RRR) sequence was responsible for the retention of ADAM10 in the ER and its inefficient surface trafficking.	Arginine	56-64	ADAM metallopeptidase domain 10	Homo sapiens	127-133
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	82-90	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	130-135
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	161-164	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	130-135
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	165-168	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	130-135
23275711-4	2012	The docking simulation revealed that GA possibly inhibits functions of HMGB1 interfering with Lys(90), Arg(91), Ser(101), Tyr(149), C(230) and C(231) in the HMGB1-DNA complex.	Arginine	103-106	high mobility group box 1	Homo sapiens	157-162
21997230-0	2012	Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.	Arginine	34-42	forkhead box P3	Homo sapiens	116-121
19901984-2	2009	Nullbasic was created by replacing the entire arginine-rich basic domain of wild type Tat with glycine/alanine residues.	Arginine	46-54	tyrosine aminotransferase	Homo sapiens	86-89
20162736-1	2010	BACKGROUND: Nebivolol is a novel, beta(1)-adrenergic receptor blocker with vasodilatory properties mediated through activation of the L-arginine/nitric oxide pathway.	Arginine	134-144	adrenoceptor beta 1	Homo sapiens	34-61
21997230-4	2012	We hypothesized that targeting FOXP3 expression with a novel arginine-rich, cell-penetrating, peptide-conjugated phosphorodiamidate morpholino (PPMO) based antisense would eliminate T(reg) and enhance the induction of effector T-cell responses.	Arginine	61-69	forkhead box P3	Homo sapiens	31-36
19717603-5	2009	Individual replacement of the two Arg residues in RcBioN reduced ATPase activity, an indicator of the transporter function, by two-thirds without affecting the modular assembly of the RcBioMNY complex.	Arginine	34-37	dynein axonemal heavy chain 8	Homo sapiens	65-71
19996805-1	2010	BACKGROUND: Myeloid cells that express arginase 1 are upregulated by different stimuli, including trauma, and are capable of depleting arginine from the surrounding environment.	Arginine	135-143	arginase 1	Homo sapiens	39-49
21872658-2	2012	In adipocytes, activated PKCepsilon (Protein kinase C epsilon) phosphorylates nuclear RIP140 which is then subsequently arginine methylated and exported to the cytoplasm.	Arginine	120-128	nuclear receptor interacting protein 1	Homo sapiens	86-92
19911255-2	2010	Matriptase activates prostasin by cleaving in the amino-terminal pro-peptide region of prostasin, presumably at the Arg residue of position 44 (R44) of the full-length human prostasin.	Arginine	116-119	serine protease 8	Homo sapiens	21-30
19717603-6	2009	A double Arg-to-Glu replacement destroyed the complex and abolished ATPase activity.	Arginine	9-12	dynein axonemal heavy chain 8	Homo sapiens	68-74
23181747-3	2012	Direct sequencing of the alpha2-globin gene revealed a substitution of codon 104 [alpha104(G11)Cys Arg, TGC&gt;CGC (alpha2) (HBA2:c.313T&gt;C)].	Arginine	99-102	hemoglobin subunit alpha 2	Homo sapiens	25-38
19712052-7	2009	In conclusion, CAT1 is localized in retinal capillary endothelial cells and at least in part mediates L-arginine transport at the inner BRB.	Arginine	102-112	solute carrier family 7 member 1	Rattus norvegicus	15-19
19911255-2	2010	Matriptase activates prostasin by cleaving in the amino-terminal pro-peptide region of prostasin, presumably at the Arg residue of position 44 (R44) of the full-length human prostasin.	Arginine	116-119	serine protease 8	Homo sapiens	87-96
19911255-2	2010	Matriptase activates prostasin by cleaving in the amino-terminal pro-peptide region of prostasin, presumably at the Arg residue of position 44 (R44) of the full-length human prostasin.	Arginine	116-119	serine protease 8	Homo sapiens	87-96
19911255-3	2010	Using an Arg-to-Ala mutant (R44A) human prostasin, we showed in this report that the cleavage of prostasin by matriptase is at Arg44.	Arginine	9-12	serine protease 8	Homo sapiens	40-49
19911255-3	2010	Using an Arg-to-Ala mutant (R44A) human prostasin, we showed in this report that the cleavage of prostasin by matriptase is at Arg44.	Arginine	9-12	serine protease 8	Homo sapiens	97-106
20213119-0	2010	Ternary system of solution additives with arginine and salt for refolding of beta-galactosidase.	Arginine	42-50	galactosidase beta 1	Homo sapiens	77-95
22619531-5	2012	PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles.	Arginine	84-92	ral guanine nucleotide dissociation stimulator	Homo sapiens	123-127
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Arginine	104-107	galactosidase beta 1	Homo sapiens	68-86
20213119-2	2010	This paper presents an investigation of the refolding of tetrameric beta-galactosidase (beta-gal) using Arg HCl and other salts.	Arginine	104-107	galactosidase beta 1	Homo sapiens	68-76
20213119-3	2010	In a binary system using only Arg HCl, the refolding yield of beta-gal increased with increasing concentration up to 0.2 M. However, the refolding yield sharply decreased above this concentration, reaching the level below the control yield of 5% at 0.5 M and near zero above 0.75 M, an observation unexpected from monomeric proteins.	Arginine	30-33	galactosidase beta 1	Homo sapiens	62-70
20111005-3	2010	The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta.	Arginine	12-20	CCAAT enhancer binding protein beta	Homo sapiens	68-77
19726520-4	2009	Tat stabilization depends on the catalytic activity of PRMT6 and requires arginine methylation within the Tat basic domain.	Arginine	74-82	tyrosine aminotransferase	Homo sapiens	0-3
19666463-6	2009	We showed age-dependent up-regulation of brain OASIS levels and processing in Arg-61 apoE mice.	Arginine	78-81	cAMP responsive element binding protein 3-like 1	Mus musculus	47-52
18821052-9	2009	In addition, Arg elevated the levels of serum interleukin-2 and interferon-gamma (P &lt; 0.05) on day 28, and mitigated the decrease of serum interferon-gamma level on day 21 (P &lt; 0.05).	Arginine	13-16	interferon gamma	Sus scrofa	64-80
20111005-3	2010	The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta.	Arginine	12-20	CCAAT enhancer binding protein beta	Homo sapiens	136-145
21972038-1	2012	The histone methyltransferase (HMT) family of proteins consists of enzymes that methylate lysine or arginine residues on histone tails as well as other proteins.	Arginine	100-108	PR/SET domain 9	Homo sapiens	4-29
20111005-3	2010	The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta.	Arginine	12-20	CCAAT enhancer binding protein beta	Homo sapiens	136-145
20111005-7	2010	Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation.	Arginine	86-94	CCAAT enhancer binding protein beta	Homo sapiens	50-59
20071328-8	2010	Another endogenous milk protease, cathepsin D, cleaved the Leu(151)-Arg(152) bond.	Arginine	68-71	cathepsin D	Homo sapiens	34-45
21972038-1	2012	The histone methyltransferase (HMT) family of proteins consists of enzymes that methylate lysine or arginine residues on histone tails as well as other proteins.	Arginine	100-108	PR/SET domain 9	Homo sapiens	31-34
22393272-7	2012	Sequencing of the candidate gene detected a heterozygous c.307C&gt;T transition in the coding region of PAX6, resulting in the substitution of a highly conserved arginine codon for a termination codon (p.R103X).	Arginine	162-170	paired box 6	Homo sapiens	104-108
20026029-6	2010	A potential target lysine in Syn67 was biotinylated by HCS only after arginine-to-glycine substitutions in Syn67 produced a histone-like peptide.	Arginine	70-78	holocarboxylase synthetase	Homo sapiens	55-58
20153031-1	2010	BACKGROUND: Disturbance in the delicate balance between L-arginine-metabolizing enzymes such as nitric oxide synthase (NOS) and arginase may lead to decreased L-arginine availability to constitutive forms of NOS (endothelial NOS), thereby increasing the nitro-oxidative stress and airway hyperresponsiveness (AHR).	Arginine	56-66	nitric oxide synthase 1, neuronal	Mus musculus	96-117
20153031-1	2010	BACKGROUND: Disturbance in the delicate balance between L-arginine-metabolizing enzymes such as nitric oxide synthase (NOS) and arginase may lead to decreased L-arginine availability to constitutive forms of NOS (endothelial NOS), thereby increasing the nitro-oxidative stress and airway hyperresponsiveness (AHR).	Arginine	159-169	nitric oxide synthase 1, neuronal	Mus musculus	96-117
19526276-2	2009	NO is synthesized through the conversion of L-arginine to L-citrulline by the enzyme NO synthase (NOS), which is found in three isoforms classified as neuronal (nNOS), inducible (iNOS), and endothelial (eNOS).	Arginine	44-54	nitric oxide synthase 1	Homo sapiens	85-96
20153031-5	2010	RESULTS: L-arginine significantly reduced AHR and airway inflammation including bronchoalveolar lavage fluid eosinophilia, T(H)2 cytokines, TGF-beta1, goblet cell metaplasia, and subepithelial fibrosis.	Arginine	9-19	transforming growth factor, beta 1	Mus musculus	140-149
23029434-0	2012	Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice.	Arginine	26-36	netrin 1	Mus musculus	0-8
20053747-8	2010	We also identified three Arg residues in nsP4, R545, R546, and R547, that are needed for the synthesis of G RNA but not SG RNA.	Arginine	25-28	serine protease 57	Homo sapiens	41-45
19655812-4	2009	To investigate whether the physical folding properties of PrP are influenced by the presence of arginine at codon 171, we have introduced the mutation at the equivalent position (codon 167) in recombinant mouse PrP.	Arginine	96-104	prion protein	Mus musculus	58-61
19655812-4	2009	To investigate whether the physical folding properties of PrP are influenced by the presence of arginine at codon 171, we have introduced the mutation at the equivalent position (codon 167) in recombinant mouse PrP.	Arginine	96-104	prion protein	Mus musculus	211-214
23029434-5	2012	Mice were treated with recombinant mouse netrin-1 at a dose of 1 microg/mouse or vehicle (0.1% BSA) intravenously through the tail vein immediately after the second injection of L-Arginine, and every 24 h thereafter.	Arginine	178-188	netrin 1	Mus musculus	41-49
22693611-6	2012	In vitro studies revealed that COUP-TFII interacts with the C-terminal arginine-glycine repeat (RGG) domain of nucleolin.	Arginine	71-79	nucleolin	Homo sapiens	111-120
19625684-6	2009	Ornithine aminotransferase, the regulated enzyme of arginine and ornithine catabolism, is restricted to the same zone 3 cells as glutamine synthetase, whereas the urea cycle is found in the remaining hepatocytes.	Arginine	52-60	ornithine aminotransferase	Homo sapiens	0-26
20112895-3	2010	To facilitate this difficult task, PMK contains 17 arginines and eight lysines.	Arginine	51-60	phosphomevalonate kinase	Homo sapiens	35-38
20112895-6	2010	Herein we report a characterization of changes to the dynamical state of the arginine side chains in PMK due to binding of its highly charged substrates, ATP and M5P.	Arginine	77-85	phosphomevalonate kinase	Homo sapiens	101-104
22363433-5	2012	Our results show that TDRD3 preferentially recognizes asymmetrical dimethylated arginine mark, and SMN is a very promiscuous effector molecule, which recognizes different arginine containing sequence motifs and preferentially binds symmetrical dimethylated arginine.	Arginine	171-179	survival of motor neuron 2, centromeric	Homo sapiens	99-102
19933271-11	2010	Tryptophan 94 (human) or 103 (yeast) is located in a positively charged region of Atp12p, and hence its mutation to arginine does not alter significantly the electrostatic properties of the protein.	Arginine	116-124	ATP synthase complex assembly protein ATP12	Saccharomyces cerevisiae S288C	82-88
19477941-3	2009	Moreover, the internalized GLUT2 protein undergoes rapid degradation induced by chronic high-glucose or arginine stimulation but does not undergo plasma membrane recycling or accumulation in any microscopically apparent intracellular membrane compartment.	Arginine	104-112	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	27-32
22363433-5	2012	Our results show that TDRD3 preferentially recognizes asymmetrical dimethylated arginine mark, and SMN is a very promiscuous effector molecule, which recognizes different arginine containing sequence motifs and preferentially binds symmetrical dimethylated arginine.	Arginine	171-179	survival of motor neuron 2, centromeric	Homo sapiens	99-102
20181083-0	2010	Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition.	Arginine	88-96	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	45-51
21880552-8	2011	Relaxation of diabetic ileum by exogenous nitric oxide generated from sodium nitroprusside was comparable to control ileum, but smooth muscle relaxation by l-arginine using neuronal nitric oxide synthase to generate nitric oxide was weaker in diabetic ileum with evidence for a role for inducible nitric oxide synthase.	Arginine	156-166	nitric oxide synthase, inducible	Cavia porcellus	287-318
19843630-2	2010	We aimed to explore whether aging alters aortic arginine uptake by CAT-1, the selective arginine supplier to eNOS in rats.	Arginine	88-96	solute carrier family 7 member 1	Rattus norvegicus	67-72
19969464-0	2010	Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors.	Arginine	95-105	alanyl aminopeptidase, membrane	Homo sapiens	109-126
22299391-3	2011	The beta1 adrenoreceptor (amino acid position 389) genotype frequencies were significantly different in the two groups; assuming a recessive model for the allelic variant coding for Arg on this position, the odds ratio was 3.14, 95% Cl 1.55-6.37 (P = 0.0015).	Arginine	182-185	adrenoceptor beta 1	Homo sapiens	4-24
19969464-0	2010	Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors.	Arginine	95-105	alanyl aminopeptidase, membrane	Homo sapiens	127-131
19969464-1	2010	A series of bi- or tri-peptide analogues with the scaffold l-arginine were designed, synthesized and evaluated for their inhibitory activities against amino-peptidase N (APN) and metalloproteinase-2 (MMP-2).	Arginine	59-69	alanyl aminopeptidase, membrane	Homo sapiens	151-168
19969464-1	2010	A series of bi- or tri-peptide analogues with the scaffold l-arginine were designed, synthesized and evaluated for their inhibitory activities against amino-peptidase N (APN) and metalloproteinase-2 (MMP-2).	Arginine	59-69	alanyl aminopeptidase, membrane	Homo sapiens	170-173
19969464-1	2010	A series of bi- or tri-peptide analogues with the scaffold l-arginine were designed, synthesized and evaluated for their inhibitory activities against amino-peptidase N (APN) and metalloproteinase-2 (MMP-2).	Arginine	59-69	matrix metallopeptidase 2	Homo sapiens	200-205
19553338-0	2009	Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.	Arginine	0-8	SRSF protein kinase 1	Homo sapiens	94-99
19617375-5	2009	We identify an in vivo ADAR3 interaction partner, importin alpha 1 (KPNA2) that specifically recognizes an arginine-rich ADAR3 sequence motif and show that it acts as a functional nuclear localization sequence.	Arginine	107-115	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	23-28
19617375-5	2009	We identify an in vivo ADAR3 interaction partner, importin alpha 1 (KPNA2) that specifically recognizes an arginine-rich ADAR3 sequence motif and show that it acts as a functional nuclear localization sequence.	Arginine	107-115	karyopherin subunit alpha 2	Homo sapiens	68-73
21563215-8	2011	The sequences and conformations are improved with respect to our previous, polar-hydrogen/CASA study: For several designed complexes, the AspAMP carboxylate forms three interactions with a conserved arginine and a designed lysine, as in the active site of the AspRS:AspAMP complex.	Arginine	199-207	aspartyl-tRNA synthetase 1	Homo sapiens	260-265
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	166-169	tyrosine aminotransferase	Homo sapiens	26-30
20606325-2	2010	CPR removes the C-terminal arginine from inflammatory peptides such as C3a and C5a, bradykinin, enkephalin, and the thrombin-cleaved N-terminal fragment osteopontin (cleaved N-OPN).	Arginine	27-35	secreted phosphoprotein 1	Mus musculus	176-179
21937424-8	2011	These higher levels of activities measured in the TREX1(R114H/D201ins) and TREX1(R114H/A124ins) compound heterodimers are attributed to Arg-114 residues of TREX1(D201ins) and TREX1(A124ins) positioned at the dimer interface contributing to the active sites of the opposing TREX1(R114H) protomer.	Arginine	136-139	three prime repair exonuclease 1	Homo sapiens	50-55
20593475-5	2010	Subsequent incorporation of a C-terminal arginine tag into the N-terminal NY-ESO-1 155-180 fragment joined by a base labile 4-hydroxymethylbenzoic acid (HMBA) linker facilitated rapid quantitative ligation.	Arginine	41-49	cancer/testis antigen 1A	Homo sapiens	74-82
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	166-169	tyrosine aminotransferase	Homo sapiens	32-36
19431148-1	2009	Arginase 1 (ARG1) inhibits T-cell proliferation by degrading extracellular arginine, which results in decreased responsiveness of T cells to CD3/TCR stimulation.	Arginine	75-83	arginase 1	Homo sapiens	0-10
19431148-1	2009	Arginase 1 (ARG1) inhibits T-cell proliferation by degrading extracellular arginine, which results in decreased responsiveness of T cells to CD3/TCR stimulation.	Arginine	75-83	arginase 1	Homo sapiens	12-16
21937424-8	2011	These higher levels of activities measured in the TREX1(R114H/D201ins) and TREX1(R114H/A124ins) compound heterodimers are attributed to Arg-114 residues of TREX1(D201ins) and TREX1(A124ins) positioned at the dimer interface contributing to the active sites of the opposing TREX1(R114H) protomer.	Arginine	136-139	three prime repair exonuclease 1	Homo sapiens	75-80
19431148-10	2009	Secreted ARG1 was biologically active and catabolized extracellular arginine.	Arginine	68-76	arginase 1	Homo sapiens	9-13
19889875-5	2010	Alanine-scanning mutagenesis was applied to the corresponding Arg residues in both the small and large subunits of maize endosperm AGPase to determine their roles in allosteric regulation and thermal stability.	Arginine	62-65	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	131-137
21937424-8	2011	These higher levels of activities measured in the TREX1(R114H/D201ins) and TREX1(R114H/A124ins) compound heterodimers are attributed to Arg-114 residues of TREX1(D201ins) and TREX1(A124ins) positioned at the dimer interface contributing to the active sites of the opposing TREX1(R114H) protomer.	Arginine	136-139	three prime repair exonuclease 1	Homo sapiens	75-80
21937424-8	2011	These higher levels of activities measured in the TREX1(R114H/D201ins) and TREX1(R114H/A124ins) compound heterodimers are attributed to Arg-114 residues of TREX1(D201ins) and TREX1(A124ins) positioned at the dimer interface contributing to the active sites of the opposing TREX1(R114H) protomer.	Arginine	136-139	three prime repair exonuclease 1	Homo sapiens	75-80
21937424-8	2011	These higher levels of activities measured in the TREX1(R114H/D201ins) and TREX1(R114H/A124ins) compound heterodimers are attributed to Arg-114 residues of TREX1(D201ins) and TREX1(A124ins) positioned at the dimer interface contributing to the active sites of the opposing TREX1(R114H) protomer.	Arginine	136-139	three prime repair exonuclease 1	Homo sapiens	75-80
20062922-6	2010	An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation of FVIII by modestly accelerating cleavage at Arg(372).	Arginine	193-196	coagulation factor VIII	Homo sapiens	150-155
20062922-11	2010	This enhancing effect could be attributed to an increase in thrombin-induced activation of FVIII, mediated by cleavage at Arg(372) and a tighter interaction of thrombin with the A2 domain.	Arginine	122-125	coagulation factor VIII	Homo sapiens	91-96
19454486-3	2009	This mutation converts a highly conserved leucine residue into arginine within a presumed trans-membrane alpha-helical segment, at position 217 of Atp6p.	Arginine	63-71	mitochondrially encoded ATP synthase 6	Homo sapiens	147-152
22101937-2	2011	We report solution structures of SMN and SPF30 Tudor domains bound to symmetric and asymmetric dimethylated arginine (DMA) that is inherent in the RNP complexes.	Arginine	108-116	survival of motor neuron 1, telomeric	Homo sapiens	33-36
19580635-10	2009	In nucleotide 52 of exon I of the DNA isolated from the hyperbiliverdinaemic patient, we discovered a novel heterozygous C-->T nonsense mutation converting an arginine (CGA) in position 18 into a stop codon (TGA) (R18Stop) predicted to truncate the protein N-terminally to the active site Tyr97.	Arginine	159-167	T-box transcription factor 1	Homo sapiens	208-211
20011517-5	2009	Genetic mapping revealed a mutation resulting in a glycine to arginine change in the catalytic domain of the aldh1a2 gene, which is required for the production of retinoic acid from vitamin A.	Arginine	62-70	aldehyde dehydrogenase 1 family, member A2	Danio rerio	109-116
22101937-2	2011	We report solution structures of SMN and SPF30 Tudor domains bound to symmetric and asymmetric dimethylated arginine (DMA) that is inherent in the RNP complexes.	Arginine	108-116	survival motor neuron domain containing 1	Homo sapiens	41-46
19815559-6	2009	Subsequent peptide mapping using chemical and proteinase cleavages of purified wild-type and mutant GLP1 receptor identified that the Arg(131)-Lys(136) segment at the juxtamembrane region of the receptor amino terminus contained the site of labeling for the position 24 probe, and the specific receptor residue labeled by this probe was identified as Glu(133) by radiochemical sequencing.	Arginine	134-137	glucagon like peptide 1 receptor	Homo sapiens	100-113
21788321-1	2011	BACKGROUND: The involvement of the L-arginine/nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway in antinociception has been implicated as a molecular mechanism of antinociception produced by several antinociceptive agents, including mu-, kappa-, or delta-opioid receptor agonists, nonsteroidal analgesics, cholinergic agonist, and alpha2C adrenoceptor agonist.	Arginine	35-45	adrenoceptor alpha 2C	Rattus norvegicus	345-365
19879767-0	2009	Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.	Arginine	37-40	opioid related nociceptin receptor 1	Homo sapiens	93-97
19879767-1	2009	[Arg(14),Lys(15)]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin.	Arginine	1-4	opioid related nociceptin receptor 1	Homo sapiens	49-53
19879767-4	2009	The mutant receptor Gln205Ala was found to be as active as wild-type ORL1 for both nociceptin and [Arg(14),Lys(15)]nociceptin.	Arginine	99-102	opioid related nociceptin receptor 1	Homo sapiens	69-73
19822661-5	2009	Importantly, maintaining the charge of the unmodified tail by arginine substitutions preserves Set2 function in vivo.	Arginine	62-70	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	95-99
20641242-12	2004	A rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	62-65	pro-opiomelanocortin-alpha	Mus musculus	19-28
20641242-12	2004	A rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	94-97	pro-opiomelanocortin-alpha	Mus musculus	19-28
19427829-5	2009	Moreover, L-arginine treatment was associated with preservation of arginase I activity and neuroprotective polyamines in spinal cord motor neurons.	Arginine	10-20	arginase, liver	Mus musculus	67-77
21247657-6	2011	We identified arginine-177 as the target for SpvB-catalyzed mono-ADP-ribosylation of actin.	Arginine	14-22	virulence protein	Salmonella enterica	45-49
19402713-13	2009	Results indicate that Arg at P5, P6, or P7 distances from P1 enhances affinity and efficiency of substrates or inhibitors toward APCE or FAP.	Arginine	22-25	fibroblast activation protein alpha	Homo sapiens	137-140
19843866-7	2009	We found that PADI4 citrullinated the histone chaperone protein, nucleophosmin (NPM1), at the arginine 197 residue in vivo under physiologic conditions.	Arginine	94-102	nucleophosmin 1	Homo sapiens	65-78
19843866-7	2009	We found that PADI4 citrullinated the histone chaperone protein, nucleophosmin (NPM1), at the arginine 197 residue in vivo under physiologic conditions.	Arginine	94-102	nucleophosmin 1	Homo sapiens	80-84
21778808-4	2011	We demonstrated that symmetric arginine dimethylation of eukaryotic elongation factor 2 (eEF2) is induced by bFGF without the change in the expression level of eEF2 in mouse embryo fibroblast NIH3T3 cells.	Arginine	31-39	fibroblast growth factor 2	Mus musculus	109-113
19737896-4	2009	Lys-for-Arg replacements in Crp4 attenuated bactericidal activity and slowed the kinetics of Escherichia coli ML35 cell permeabilization, and (R/K)-Crp4 required longer exposure times to reduce E. coli cell survival.	Arginine	8-11	defensin, alpha, 4	Mus musculus	28-32
19737896-6	2009	Therefore, Arg--&gt;Lys substitutions attenuated activity in Crp4 but not in RMAD-4, and the functional consequences of Arg--&gt;Lys replacements in alpha-defensins are dependent on the peptide primary structure.	Arginine	11-14	defensin, alpha, 4	Mus musculus	61-65
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	29-32	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	98-107
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	38-41	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	98-107
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	38-41	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	98-107
19737896-7	2009	In addition, the bactericidal effects of (R/K)-Crp4 and (R/K)-RMAD-4 were more sensitive to inhibition by NaCl than those of the native peptides, suggesting that the high Arg content of alpha-defensins may be under selection to confer superior microbicidal function under physiologic conditions.	Arginine	171-174	defensin, alpha, 4	Mus musculus	47-51
19336400-12	2009	In contrast, replacing Arg(82)/Arg(93) in ST8Sia IV with alanine substantially decreased NCAM-specific polysialylation while only partially impacting autopolysialylation, suggesting that these residues may be particularly important for NCAM polysialylation.	Arginine	23-26	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	42-45
21778808-7	2011	Collectively, we demonstrated that eEF2, a key factor involved in protein translational elongation is symmetrically arginine-methylated in a reversible manner, being regulated by bFGF through MAPK signaling pathway.	Arginine	116-124	fibroblast growth factor 2	Mus musculus	179-183
19336400-12	2009	In contrast, replacing Arg(82)/Arg(93) in ST8Sia IV with alanine substantially decreased NCAM-specific polysialylation while only partially impacting autopolysialylation, suggesting that these residues may be particularly important for NCAM polysialylation.	Arginine	31-34	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	42-45
19544422-7	2009	In CARM1 overexpressing ES cells, histone H3 arginine methylation is also at the Nanog promoter to which CARM1 now associates.	Arginine	45-53	coactivator-associated arginine methyltransferase 1	Mus musculus	3-8
21719758-1	2011	RATIONALE: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor that competes with L-arginine for binding to NOS.	Arginine	120-130	nitric oxide synthase 1, neuronal	Mus musculus	63-84
19544422-7	2009	In CARM1 overexpressing ES cells, histone H3 arginine methylation is also at the Nanog promoter to which CARM1 now associates.	Arginine	45-53	coactivator-associated arginine methyltransferase 1	Mus musculus	105-110
19544422-9	2009	Thus, like in four-cell embryo blastomeres, histone H3 arginine methylation by CARM1 in ES cells allows epigenetic modulation of pluripotency.	Arginine	55-63	coactivator-associated arginine methyltransferase 1	Mus musculus	79-84
19802384-10	2009	Furthermore, we prove that the RMKKK sequence of syndecan-1 is necessary and sufficient for nuclear translocation, acting as a nuclear localization signal, and the Arginine residue is vital for this localization.	Arginine	164-172	syndecan 1	Homo sapiens	49-59
21515310-4	2011	In the brain L-arginine is converted into NO and citrulline by the enzyme, neuronal NOS (nNOS).	Arginine	13-23	nitric oxide synthase 1, neuronal	Mus musculus	75-87
18821052-9	2009	In addition, Arg elevated the levels of serum interleukin-2 and interferon-gamma (P &lt; 0.05) on day 28, and mitigated the decrease of serum interferon-gamma level on day 21 (P &lt; 0.05).	Arginine	13-16	interferon gamma	Sus scrofa	142-158
19130895-7	2009	In addition, structural analysis revealed that, while AK4 retains the capability of binding nucleotides, AK4 has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs.	Arginine	150-158	adenylate kinase 4	Homo sapiens	105-108
21515310-4	2011	In the brain L-arginine is converted into NO and citrulline by the enzyme, neuronal NOS (nNOS).	Arginine	13-23	nitric oxide synthase 1, neuronal	Mus musculus	89-93
21664432-3	2011	In our current study, we found that intraplantar injection of the NOS substrate L-arginine or NO donor 3-morpholino-synonimine (SIN-1) produced mechanical hypersensitivity that lasted more than 24 h. Following L5 spinal nerve ligation (L5 SNL), immunoreactivity for nNOS in the ipsilateral L5 but not L4 dorsal root ganglion (DRG) was dramatically increased in mainly small- and medium-sized neurons and non-neuronal cells.	Arginine	80-90	nitric oxide synthase 1	Homo sapiens	266-270
19238562-5	2009	The mapping of deletion mutants of atSR45a proteins revealed that the C-terminal arginine/serine-rich (RS) domain of atSR45a proteins are required for the interaction with U1-70K, U2AF(35)b, atSR45, atSCL28, PRP38-like protein, and themselves, and the N-terminal RS domain enhances the interaction efficiency.	Arginine	81-89	arginine/serine-rich 45	Arabidopsis thaliana	35-41
19238562-5	2009	The mapping of deletion mutants of atSR45a proteins revealed that the C-terminal arginine/serine-rich (RS) domain of atSR45a proteins are required for the interaction with U1-70K, U2AF(35)b, atSR45, atSCL28, PRP38-like protein, and themselves, and the N-terminal RS domain enhances the interaction efficiency.	Arginine	81-89	SC35-like splicing factor 28	Arabidopsis thaliana	199-206
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	carboxypeptidase B2	Homo sapiens	59-102
21884984-3	2011	We show that the neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100/SRRM4) negatively regulates REST (NRSF), a transcriptional repressor of genes required for neurogenesis.	Arginine	37-40	RE1-silencing transcription factor	Mus musculus	117-121
19752231-8	2009	A central pocket binds arginine 83, the only Bw4 motif residue essential for KIR3DL1 interaction, similar to the binding of lysine 80 in HLA-C by KIR2DL1.	Arginine	23-31	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	Mus musculus	77-84
19327364-6	2009	Mutagenesis of key arginine residues in the DNA contact sequence results in the loss of specific interaction of the PEST sequence with the p65 subdomain.	Arginine	19-27	RELA proto-oncogene, NF-kB subunit	Homo sapiens	139-142
23554705-2	2011	Lung concentrations of NO and its amino acid precursor, L-arginine, are regulated by the relative expressions of the NO synthase (NOS) and arginase isoforms.	Arginine	56-66	nitric oxide synthase 1, neuronal	Mus musculus	117-128
19293328-9	2009	Ischemia markedly potentiated the expression of arginase-1, a cytosolic enzyme that metabolizes the precursor of nitric oxide l-arginine.	Arginine	126-136	arginase 1	Homo sapiens	48-58
19650765-10	2009	Importantly, sub-culturing isolated rat aortic segments for 7 days in the presence of L-arginine at 37 degrees C stimulated *NO production with a parallel increase in Mb in the underlying VSMCs.	Arginine	86-96	myoglobin	Rattus norvegicus	167-169
21804013-9	2011	Finally, we found plasma l-arginine depletion in the acute phase of infection that was coincident in time with the appearance of MDSCs, suggesting that in vivo arginase I could be contributing to l-arginine depletion and systemic immunosuppression.	Arginine	25-35	arginase, liver	Mus musculus	160-170
19635796-4	2009	The nonconserved amino acid residues in the putative dimer interface of AZI (Ser-277, Ser-331, Glu-332, and Asp-389) were substituted with the corresponding residues in the putative dimer interface of ODC (Arg-277, Tyr-331, Asp-332, and Tyr-389, respectively).	Arginine	206-209	ornithine decarboxylase antizyme 1	Homo sapiens	72-75
19635796-4	2009	The nonconserved amino acid residues in the putative dimer interface of AZI (Ser-277, Ser-331, Glu-332, and Asp-389) were substituted with the corresponding residues in the putative dimer interface of ODC (Arg-277, Tyr-331, Asp-332, and Tyr-389, respectively).	Arginine	206-209	ornithine decarboxylase 1	Homo sapiens	201-204
19501636-1	2009	Nitric oxide synthase (NOS) produces nitric oxide (NO) from arginine.	Arginine	60-68	nitric oxide synthase 1 (neuronal)	Danio rerio	0-21
19374401-1	2009	There are three isoforms of dimeric nitric oxide synthases (NOS) that convert arginine to citrulline and nitric oxide.	Arginine	78-86	nitric oxide synthase 1, neuronal	Mus musculus	36-58
19290671-1	2009	Nitric oxide synthases (NOS) are modular, calmodulin- (CaM-) dependent, flavoheme enzymes that catalyze oxidation of l-arginine to generate nitric oxide (NO) and citrulline.	Arginine	117-127	calmodulin 1	Rattus norvegicus	42-60
21804013-9	2011	Finally, we found plasma l-arginine depletion in the acute phase of infection that was coincident in time with the appearance of MDSCs, suggesting that in vivo arginase I could be contributing to l-arginine depletion and systemic immunosuppression.	Arginine	196-206	arginase, liver	Mus musculus	160-170
21775629-8	2011	The piNG-body destruction caused by csul mutations that abolish specific posttranslational symmetrical arginine methylation of PIWI proteins is accompanied by strong derepression of Stellate genes known to be silenced via the piRNA pathway.	Arginine	103-111	P-element induced wimpy testis	Drosophila melanogaster	127-131
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Arginine	121-131	CDAN3	Homo sapiens	74-79
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Arginine	121-131	CDAN3	Homo sapiens	240-245
21873235-3	2011	Here we report that Malt1 cleaved the NF-kappaB family member RelB after Arg-85.	Arginine	73-76	MALT1 paracaspase	Homo sapiens	20-25
21620933-4	2011	GluR2 confers special properties on AMPA receptors through the presence of arginine at the pore apex; other subunits (GluR1, 3, 4) contain glutamine at the pore apex and allow Ca2+ influx.	Arginine	75-83	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	0-5
19260709-3	2009	Prior studies on protein tyrosine kinases Csk and Src revealed the potential for chemical rescue of catalytically deficient mutant kinases (Arg to Ala mutations) by small diamino compounds, particularly imidazole; however, the potency and efficiency of rescue was greater for Src.	Arginine	140-143	C-terminal Src kinase	Homo sapiens	42-45
21438724-4	2011	All tested enzymes produced a dose-dependent cleavage of TATp as shown by the presence of TATp Arg-Arg fragments.	Arginine	95-98	tyrosine aminotransferase	Mus musculus	57-61
19204007-7	2009	Using mass spectrometry, we found that the cp-2 fragment is generated by cleavage of huntingtin at position Arg(167).	Arginine	108-111	huntingtin	Homo sapiens	85-95
19204007-10	2009	These data suggest that cleavage of huntingtin at residue Arg(167) may mediate mutant huntingtin toxicity in Huntington disease.	Arginine	58-61	huntingtin	Homo sapiens	36-46
19204007-10	2009	These data suggest that cleavage of huntingtin at residue Arg(167) may mediate mutant huntingtin toxicity in Huntington disease.	Arginine	58-61	huntingtin	Homo sapiens	86-96
21438724-4	2011	All tested enzymes produced a dose-dependent cleavage of TATp as shown by the presence of TATp Arg-Arg fragments.	Arginine	95-98	tyrosine aminotransferase	Mus musculus	90-94
21438724-4	2011	All tested enzymes produced a dose-dependent cleavage of TATp as shown by the presence of TATp Arg-Arg fragments.	Arginine	99-102	tyrosine aminotransferase	Mus musculus	57-61
21438724-4	2011	All tested enzymes produced a dose-dependent cleavage of TATp as shown by the presence of TATp Arg-Arg fragments.	Arginine	99-102	tyrosine aminotransferase	Mus musculus	90-94
21543315-3	2011	In this work, sequence alignments of hSBDb with the E3-binding domain (E3BD) of the mammalian pyruvate dehydrogenase complex show that hSBDb has an arginine at position 118, where E3BD features an asparagine.	Arginine	148-156	dihydrolipoamide dehydrogenase	Homo sapiens	52-54
19232356-9	2009	Tudor-SN preferentially recognizes sDMA over asymmetrically dimethylated arginine (aDMA).	Arginine	73-81	Tudor staphylococcal nuclease	Drosophila melanogaster	0-8
21543315-7	2011	The structure showed that the presence of Arg-118 poses a unique, possibly steric and/or electrostatic incompatibility that could impede E3 interactions with the wild-type hSBDb.	Arginine	42-45	dihydrolipoamide dehydrogenase	Homo sapiens	137-139
19241467-10	2009	Thirty-one percent (36 of 115) of all mutations and 41% (29 of 71) of missense mutations occurred in arginine residues in TGase-1.	Arginine	101-109	transglutaminase 1	Homo sapiens	122-129
19241467-12	2009	We constructed a model of human TGase-1 and showed that all mutated arginines that reside in the two beta-barrel domains and two (R142 and R143) in the beta-sandwich are located at domain interfaces.	Arginine	68-77	transglutaminase 1	Homo sapiens	32-39
21543315-9	2011	Solution NMR data corroborated the interactions of hE3 with Arg-118 and Asn-118 in wild-type hSBDb and mutant hSBDb*, respectively.	Arginine	60-63	dihydrolipoamide dehydrogenase	Homo sapiens	51-54
19241467-14	2009	The high frequency of mutated arginine codons in TGM1 may be due to the deamination of 5" methylated CpG dinucleotides.	Arginine	30-38	transglutaminase 1	Homo sapiens	49-53
21614098-8	2011	RESULTS: After treatment with arginine, the growth plate width of tibia and osteoblast surface of femur were increased (P &lt; 0.05), and serum GH concentration was elevated (P &lt; 0.05).	Arginine	30-38	gonadotropin releasing hormone receptor	Rattus norvegicus	144-146
19168731-8	2009	Mass spectrometric analyses of IL-4 and IL-5 showed that hydrolysis by RgpA-Kgp complexes was C terminal to Arg and Lys residues of the cytokines.	Arginine	108-111	interleukin 5	Homo sapiens	40-44
21614098-10	2011	CONCLUSION: Oral administration of arginine could improve linear growth of long bones by regulating mRNA expression of SS and Gh and inducing GH secretion, possibly via nNOS-NO-sGC-cGMP signal transduction pathway.	Arginine	35-43	gonadotropin releasing hormone receptor	Rattus norvegicus	142-144
21423010-8	2011	Restoring bioavailable nitric oxide by administration of inhaled nitric oxide or its substrate, L-arginine, may rescue endothelial function, decrease Ang-2, and improve disease outcome in cerebral malaria.	Arginine	96-106	angiopoietin 2	Homo sapiens	150-155
19360123-9	2009	However, when exogenous L-arginine was provided, T cell proliferation was restored, suggesting that Arg1-expressing macrophages deplete arginine, which is required to sustain CD4(+) T cell responses.	Arginine	24-34	arginase, liver	Mus musculus	100-104
19360123-9	2009	However, when exogenous L-arginine was provided, T cell proliferation was restored, suggesting that Arg1-expressing macrophages deplete arginine, which is required to sustain CD4(+) T cell responses.	Arginine	26-34	arginase, liver	Mus musculus	100-104
21404362-4	2011	As well, an homology model of the three-dimensional structure of human hemopexin is used to reveal that the protein lacks the catalytic triad that is characteristic of many serine proteases but that hemopexin possesses two highly exposed Arg-Gly-Glu sequences that may promote interaction with cell surfaces.	Arginine	238-241	hemopexin	Homo sapiens	71-80
19233144-1	2009	Transcription of the arginine biosynthetic gene ARG1 is activated by Gcn4p, a transcription factor induced by starvation for any amino acid.	Arginine	21-29	arginase 1	Homo sapiens	48-52
19146426-8	2009	This His/Arg-18 mutation results in reduced affinity binding of human IAPP to insulin in comparison to rat IAPP as it is detected by surface plasmon resonance biosensor analysis.	Arginine	9-12	islet amyloid polypeptide	Homo sapiens	70-74
19181385-6	2009	The loss of GANP caused up-regulation of phosphorylation and arginine dimethylation of STAT6 in B cells after stimulation with LPS and IL-4 in vitro.	Arginine	61-69	signal transducer and activator of transcription 6	Mus musculus	87-92
19181385-9	2009	GANP down-regulates JAK1/JAK3 to STAT6-signaling with regulation of arginine methylation activity, which might be responsible for the B cell endogenous suppressive mechanism of hyper-IgE.	Arginine	68-76	Janus kinase 1	Mus musculus	20-24
19181385-9	2009	GANP down-regulates JAK1/JAK3 to STAT6-signaling with regulation of arginine methylation activity, which might be responsible for the B cell endogenous suppressive mechanism of hyper-IgE.	Arginine	68-76	Janus kinase 3	Mus musculus	25-29
19181385-9	2009	GANP down-regulates JAK1/JAK3 to STAT6-signaling with regulation of arginine methylation activity, which might be responsible for the B cell endogenous suppressive mechanism of hyper-IgE.	Arginine	68-76	signal transducer and activator of transcription 6	Mus musculus	33-38
18803481-5	2009	To manipulate EC adhesion, migration, and tubulogenesis, the surface of PEGDA hydrogels was micropatterned with a cell adhesive ligand, Arg-Gly-Asp-Ser (RGDS), in desired concentrations and geometries.	Arginine	136-139	ral guanine nucleotide dissociation stimulator	Homo sapiens	153-157
18983266-6	2009	Arg(333) and Lys(348) in the C-terminal tail of the beta2AR were identified as crucial determinants for Rab11 binding.	Arginine	0-3	RAB11A, member RAS oncogene family	Homo sapiens	104-109
19007981-1	2009	Arginine-grafted bioreducible poly(disulfide amine) (ABP) polymer was synthesized for non-viral gene delivery systems.	Arginine	0-8	amine oxidase copper containing 1	Homo sapiens	53-56
19036482-7	2009	Subsequent gene expression analysis demonstrated that arginine increased the expression of caspase 8, which was validated at the protein level.	Arginine	54-62	caspase 8	Homo sapiens	91-100
19036482-8	2009	CONCLUSIONS: These results suggest that that inhibition of AGS cell growth by arginine is mediated through caspase 8 activation of apoptosis.	Arginine	78-86	caspase 8	Homo sapiens	107-116
19106310-8	2009	However, arginine treatment resulted in lower serum concentrations of leptin, glucose, triglycerides, urea, glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance.	Arginine	9-17	leptin	Rattus norvegicus	70-76
18981217-4	2009	Interestingly, a mutant cyclin G1 (8KR) in which all lysine residues in this region have been replaced with arginine can be both ubiquitinated in cells and stabilized by a proteasome inhibitor to a similar extent as wild-type cyclin G(1-137).	Arginine	108-116	cyclin G1	Homo sapiens	24-33
19185003-3	2009	The archetypal PPIase is the human cyclophilin 18 (Cyp18 or CypA), and Arg 55 has been demonstrated to play a crucial role when studying short peptide substrates in the catalytic action of Cyp18 by stabilizing the transition state of isomerization.	Arginine	71-74	peptidylprolyl isomerase like 2	Homo sapiens	15-21
19027033-1	2009	Arginase has been suggested to compete with nitric oxide synthase (NOS) for their common substrate, l-arginine.	Arginine	100-110	nitric oxide synthase 1, neuronal	Mus musculus	44-65
19013433-5	2009	By introducing point mutations of these residues within the proposed binding domains, we experimentally confirmed that arginine 279, glutamic acid 246 in Smad3 and glutamic acid 1321 in Erbin are important for the binding.	Arginine	119-127	SMAD family member 3	Homo sapiens	154-159
19912639-6	2009	RESULTS: The data confirm our previous finding of a significant increase in patients with AS of allele A at SNP rs1264457 encoding for an Arg at the functional HLA-E polymorphism (Arg128/Gly128).	Arginine	138-141	major histocompatibility complex, class I, E	Homo sapiens	160-165
19526861-2	2009	We found that systematically trained girls had a higher level of nitric oxide synthesis through calcium-dependent L-arginine oxidation by constitutive NO-synthase isoforms (eNOS, nNOS) and through reduction of stable oxidized NO metabolites.	Arginine	114-124	nitric oxide synthase 1	Homo sapiens	179-183
19352504-7	2009	Further, using the in vitro cleavage of the purified prodomain and the analyses of colon carcinoma LoVo cells with the reconstituted expression of the wild-type and mutant furins, we demonstrated that a three-step autocatalytic processing including the cleavage of the prodomain at the previously unidentified Arg-Leu-Gln-Arg(89) downward arrowGlu(90) site, is required for the efficient activation of furin.	Arginine	310-313	furin, paired basic amino acid cleaving enzyme	Homo sapiens	172-177
19352504-7	2009	Further, using the in vitro cleavage of the purified prodomain and the analyses of colon carcinoma LoVo cells with the reconstituted expression of the wild-type and mutant furins, we demonstrated that a three-step autocatalytic processing including the cleavage of the prodomain at the previously unidentified Arg-Leu-Gln-Arg(89) downward arrowGlu(90) site, is required for the efficient activation of furin.	Arginine	322-325	furin, paired basic amino acid cleaving enzyme	Homo sapiens	172-177
18945674-4	2008	Inhibition, depletion, or knockout of the Abl family kinases, Abl and Arg, resulted in a dramatic reduction in the intracellular activities of the lysosomal glycosidases alpha-galactosidase, alpha-mannosidase and neuraminidase.	Arginine	70-73	neuraminidase 1	Homo sapiens	213-226
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	158-161	GDNF family receptor alpha 1	Homo sapiens	137-148
18845535-10	2008	Interestingly, in our structure, sucrose octasulfate also binds to the Arg(190)-Lys(202) region in GFR alpha 1 domain 2.	Arginine	71-74	GDNF family receptor alpha 1	Homo sapiens	99-110
18958581-0	2008	Treatment of a citrin-deficient patient at the early stage of adult-onset type II citrullinaemia with arginine and sodium pyruvate.	Arginine	102-110	solute carrier family 25 member 13	Homo sapiens	15-21
18958581-3	2008	In the present study, the clinical symptoms and laboratory findings are reported for a 13-year-old citrin-deficient girl in the early stage of adult-onset type II citrullinaemia (CTLN2), and the therapeutic effect of orally administered arginine and sodium pyruvate was investigated.	Arginine	237-245	solute carrier family 25 member 13	Homo sapiens	99-105
18958581-3	2008	In the present study, the clinical symptoms and laboratory findings are reported for a 13-year-old citrin-deficient girl in the early stage of adult-onset type II citrullinaemia (CTLN2), and the therapeutic effect of orally administered arginine and sodium pyruvate was investigated.	Arginine	237-245	solute carrier family 25 member 13	Homo sapiens	179-184
19737518-3	2009	Through a genome-wide computational and expression profiling strategy, we have identified a tissue- and vertebrate-restricted Ser/Arg (SR) repeat splicing factor, the neural-specific SR-related protein of 100 kDa (nSR100).	Arginine	130-133	serine/arginine repetitive matrix 4	Homo sapiens	167-212
19737518-3	2009	Through a genome-wide computational and expression profiling strategy, we have identified a tissue- and vertebrate-restricted Ser/Arg (SR) repeat splicing factor, the neural-specific SR-related protein of 100 kDa (nSR100).	Arginine	130-133	serine/arginine repetitive matrix 4	Homo sapiens	214-220
19725955-2	2009	Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9.	Arginine	43-51	coactivator-associated arginine methyltransferase 1	Mus musculus	73-78
19725955-2	2009	Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9.	Arginine	43-51	SRY (sex determining region Y)-box 9	Mus musculus	144-148
19725955-6	2009	Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.	Arginine	0-3	SRY (sex determining region Y)-box 9	Mus musculus	19-23
19725955-6	2009	Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.	Arginine	0-3	coactivator-associated arginine methyltransferase 1	Mus musculus	27-32
19725955-6	2009	Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.	Arginine	0-3	SRY (sex determining region Y)-box 9	Mus musculus	57-61
19641853-4	2009	We used (15)N spin relaxation experiments and molecular dynamics simulations to monitor the backbone amides and secondary amines of the tryptophan and arginine side chains in the ligand-free and lactose-bound states of Gal3.	Arginine	151-159	galectin 3	Homo sapiens	219-223
19617375-5	2009	We identify an in vivo ADAR3 interaction partner, importin alpha 1 (KPNA2) that specifically recognizes an arginine-rich ADAR3 sequence motif and show that it acts as a functional nuclear localization sequence.	Arginine	107-115	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	121-126
19563810-0	2009	Non-receptor tyrosine kinases c-Abl and Arg regulate the activity of C/EBPbeta.	Arginine	40-43	CCAAT enhancer binding protein beta	Homo sapiens	69-78
19563810-3	2009	The Y79 amino acid residue of C/EBPbeta was phosphorylated by c-Abl or Arg.	Arginine	71-74	CCAAT enhancer binding protein beta	Homo sapiens	30-39
19552406-0	2009	Evaluation of a novel Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for potential melanoma therapy.	Arginine	22-25	pro-opiomelanocortin-alpha	Mus musculus	45-81
19552406-2	2009	METHODS: The RGD motif {cyclic(Arg-Gly-Asp-DTyr-Asp)} was coupled to [Cys(3,4,10), DPhe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} to generate RGD-Lys-(Arg(11))CCMSH hybrid peptide.	Arginine	31-34	pro-opiomelanocortin-alpha	Mus musculus	100-109
19552406-2	2009	METHODS: The RGD motif {cyclic(Arg-Gly-Asp-DTyr-Asp)} was coupled to [Cys(3,4,10), DPhe(7), Arg(11)]alpha-MSH(3-13) {(Arg(11))CCMSH} to generate RGD-Lys-(Arg(11))CCMSH hybrid peptide.	Arginine	92-95	pro-opiomelanocortin-alpha	Mus musculus	100-109
19577933-8	2009	The results indicate that specific interactions feasible for Arg/Lys and Trp in common must be there for aromatic residues in ORL1, thus forming a cation/pi interaction or pi/pi hydrophobic interaction.	Arginine	61-64	opioid related nociceptin receptor 1	Homo sapiens	126-130
19172319-5	2009	However, detailed comparison of our modeled structure of ZPI/FXa with that of AT3/FXa points to differences in interaction specificity at the reactive center and in the stability of the inhibitory complex, due to the presence of a tyrosine residue at the P1 position in ZPI, instead of the P1 arginine residue in AT3.	Arginine	293-301	serpin family A member 10	Homo sapiens	57-60
19497050-5	2009	Various biochemical assays showed that the N-terminus of Calnuc interacts with an arginine-rich region in the cytosolic tail of LRP9.	Arginine	82-90	nucleobindin 1	Homo sapiens	57-63
19467247-1	2009	AIMS: Arginine methylation catalyzed by protein N-arginine methyltransferase (PRMT) 1 is implicated in a variety of cellular processes, although the potential role of PRMT1-mediated methylation in glucose intolerance has not been defined.	Arginine	6-14	protein arginine methyltransferase 1	Rattus norvegicus	48-85
19467247-1	2009	AIMS: Arginine methylation catalyzed by protein N-arginine methyltransferase (PRMT) 1 is implicated in a variety of cellular processes, although the potential role of PRMT1-mediated methylation in glucose intolerance has not been defined.	Arginine	6-14	protein arginine methyltransferase 1	Rattus norvegicus	167-172
19399876-1	2009	Mesencephalic astrocyte-derived neurotrophic factor (MANF), also known as arginine-rich, mutated in early stage of tumors (ARMET), is a secreted protein that reduces endoplasmic reticulum (ER) stress.	Arginine	74-82	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	0-51
19399876-1	2009	Mesencephalic astrocyte-derived neurotrophic factor (MANF), also known as arginine-rich, mutated in early stage of tumors (ARMET), is a secreted protein that reduces endoplasmic reticulum (ER) stress.	Arginine	74-82	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	53-57
19399876-1	2009	Mesencephalic astrocyte-derived neurotrophic factor (MANF), also known as arginine-rich, mutated in early stage of tumors (ARMET), is a secreted protein that reduces endoplasmic reticulum (ER) stress.	Arginine	74-82	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	123-128
19447293-1	2009	Marked reduction of RNA editing at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit type 2 (GluR2) in motor neurons may be a contributory cause of neuronal death specifically in sporadic ALS.	Arginine	53-61	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	113-118
19403727-4	2009	Isoform 1 (SR45.1) has an insertion relative to isoform 2 (SR45.2) that replaces a single arginine with eight amino acids (TSPQRKTG).	Arginine	90-98	arginine/serine-rich 45	Arabidopsis thaliana	11-15
19403727-4	2009	Isoform 1 (SR45.1) has an insertion relative to isoform 2 (SR45.2) that replaces a single arginine with eight amino acids (TSPQRKTG).	Arginine	90-98	arginine/serine-rich 45	Arabidopsis thaliana	59-63
19528482-4	2009	As expected, these enhancements were markedly suppressed with the addition of anti-alphavbeta3 antibody or arginine-glycine-aspartic acid serine (RGDS) peptide to the medium.	Arginine	107-115	ral guanine nucleotide dissociation stimulator	Homo sapiens	146-150
19490059-2	2009	Human FcgammaRIIa receptor (CD32) plays a crucial role in the phagocytosis of IgG(2) ICs and a functional point mutation 131His/Arg diminishes IgG(2) binding to the receptor.	Arginine	128-131	Fc gamma receptor IIa	Homo sapiens	6-17
19490059-2	2009	Human FcgammaRIIa receptor (CD32) plays a crucial role in the phagocytosis of IgG(2) ICs and a functional point mutation 131His/Arg diminishes IgG(2) binding to the receptor.	Arginine	128-131	Fc gamma receptor IIa	Homo sapiens	28-32
19490059-7	2009	CONCLUSIONS: Our data demonstrate that FcgammaRIIa 131His/Arg polymorphism is associated with subclinical atherosclerosis in non-smoking subjects.	Arginine	58-61	Fc gamma receptor IIa	Homo sapiens	39-50
19414808-2	2009	Historically, CPN has been implicated as a major regulator of inflammation by its enzymatic cleavage of functionally important arginine and lysine amino acids from potent phlogistic molecules, such as the complement anaphylatoxins C3a and C5a.	Arginine	127-135	carboxypeptidase N, polypeptide 1	Mus musculus	14-17
18852457-2	2008	Because its affinity for CXCR2 was particularly high, we hypothesized that MIF may feature structural motives shared by canonical CXCR2 ligands, namely the conserved N-terminal Glu-Leu-Arg (ELR) motif.	Arginine	185-188	macrophage migration inhibitory factor	Homo sapiens	75-78
21404362-4	2011	As well, an homology model of the three-dimensional structure of human hemopexin is used to reveal that the protein lacks the catalytic triad that is characteristic of many serine proteases but that hemopexin possesses two highly exposed Arg-Gly-Glu sequences that may promote interaction with cell surfaces.	Arginine	238-241	hemopexin	Homo sapiens	199-208
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	8-16	ribonucleotide reductase catalytic subunit M1	Homo sapiens	208-212
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	236-244	ribonucleotide reductase catalytic subunit M1	Homo sapiens	208-212
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	236-244	ribonucleotide reductase catalytic subunit M1	Homo sapiens	208-212
20641258-12	2004	To improve the tumor/kidney uptake ratio and stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	118-121	pro-opiomelanocortin-alpha	Mus musculus	75-84
20641258-12	2004	To improve the tumor/kidney uptake ratio and stability, a rhenium-cyclized alpha-MSH analog, Re-[Cys(3,4,10),D-Phe(7),Arg(11)]alpha-MSH3-13 (Re-CCMSH(Arg(11))), was conjugated with DOTA.	Arginine	150-153	pro-opiomelanocortin-alpha	Mus musculus	75-84
21559489-6	2011	Our studies revealed that both LANA proteins contain an N-terminal arginine/glycine (RG)-rich domain spanning a conserved chromatin-binding motif, which binds directly to importin beta1 in a RanGTP-sensitive manner and serves as an NLS in the importin beta1-mediated non-classical nuclear import pathway.	Arginine	67-75	LANA	Human gammaherpesvirus 8	31-35
19285506-9	2009	Using a shorter and more soluble version of i3_cyc, which encompassed the putative site of gC1qR binding, we showed by NMR saturation transfer difference spectroscopy that the binding surface corresponded to the central arginine cluster.	Arginine	220-228	complement C1q binding protein	Homo sapiens	91-96
18854029-1	2008	BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins.	Arginine	284-292	ADP-ribosyltransferase 3 (inactive)	Homo sapiens	18-21
21490965-3	2011	In contrast to PDGF-A(S), the PDGF-A(L) isoform has a lysine and arginine rich carboxy-terminal extension that acts as an extracellular matrix retention motif.	Arginine	65-73	platelet derived growth factor, alpha	Mus musculus	30-36
18706698-7	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	secreted phosphoprotein 1	Mus musculus	103-114
19252093-8	2009	Mutagenesis studies demonstrated that the arginine residues forming the basic spine structure on the LOX-1 ligand-binding interface were dispensable for CRP binding, suggesting a novel ligand-binding mechanism for LOX-1, distinct from that used for oxLDL binding.	Arginine	42-50	oxidized low density lipoprotein receptor 1	Homo sapiens	101-106
21466672-1	2011	BACKGROUND: Hemoglobin A2" (delta 16 Gly   Arg) is globally the commonest delta chain variant of HbA2.	Arginine	43-46	hemoglobin subunit alpha 2	Homo sapiens	97-101
19106217-0	2009	Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine.	Arginine	147-155	gonadotropin releasing hormone receptor	Rattus norvegicus	18-32
17935691-3	2008	The Twin-arginine translocation pathway, termed Tat-pathway, catalyses the translocation of secretory proteins in their folded state.	Arginine	9-17	tyrosine aminotransferase	Homo sapiens	48-51
21262773-7	2011	In contrast, mutation of Arg-57 selectively reversed the inhibition of SHP target genes and metabolic outcomes.	Arginine	25-28	nuclear receptor subfamily 0 group B member 2	Homo sapiens	71-74
21262773-8	2011	The importance of Arg-57 methylation for the repression activity of SHP provides a molecular basis for the observation that a natural mutation of Arg-57 in humans is associated with the metabolic syndrome.	Arginine	18-21	nuclear receptor subfamily 0 group B member 2	Homo sapiens	68-71
19377467-0	2009	Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.	Arginine	0-8	P-element induced wimpy testis	Drosophila melanogaster	24-28
19377467-5	2009	We report that the Drosophila homologue of protein methyltransferase 5 (dPRMT5, csul/dart5), which is also the product of a grandchildless gene, is required for arginine methylation of Drosophila Piwi, Ago3 and Aub proteins in vivo.	Arginine	161-169	P-element induced wimpy testis	Drosophila melanogaster	196-200
21262773-8	2011	The importance of Arg-57 methylation for the repression activity of SHP provides a molecular basis for the observation that a natural mutation of Arg-57 in humans is associated with the metabolic syndrome.	Arginine	146-149	nuclear receptor subfamily 0 group B member 2	Homo sapiens	68-71
21306777-4	2011	Heavy chain CDR3 (H-CDR3) arginine residues have been shown to be crucial for ganglioside recognition, but less important for anti-idiotypic antibody binding.	Arginine	26-34	CDR3	Homo sapiens	12-16
19365714-9	2009	The immunoblotting results of immunoprecipitated hnRNP I and NonO protein are consistent with arginine methylation in both proteins.	Arginine	94-102	non-POU domain containing octamer binding	Homo sapiens	61-65
18498758-10	2008	Subsequently replacing ARG8(m) with mutated versions of cytochrome b results in arginine auxotrophy.	Arginine	80-88	cytochrome b	Saccharomyces cerevisiae S288C	56-68
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	EWS RNA binding protein 1	Homo sapiens	163-166
21306777-4	2011	Heavy chain CDR3 (H-CDR3) arginine residues have been shown to be crucial for ganglioside recognition, but less important for anti-idiotypic antibody binding.	Arginine	26-34	CDR3	Homo sapiens	18-24
21306777-8	2011	Another antibody that recognizes N-glycolyl-GM3 ganglioside (GM3(Neu5Gc)), but not other glycolipids, named 14F7, exhibits also an arginine-enriched H-CDR3 and a complement-independent cell death activity.	Arginine	131-139	CDR3	Homo sapiens	149-155
19374748-3	2009	Of the two arginine-degrading enzymes being explored clinically, arginine deiminase is a decidedly foreign mycoplasm-derived enzyme, whereas human arginase 1 is a native liver enzyme.	Arginine	11-19	arginase 1	Homo sapiens	147-157
21239484-3	2011	Arginine deficiency inhibited GH secretion and decreased liver Igf1 mRNA and plasma IGF1 concentration, but did not change muscle IGF1 concentration.	Arginine	0-8	insulin-like growth factor 1	Mus musculus	63-67
19416171-6	2009	Further receptor mutagenesis showed that activation of the Galpha(i3)-Gbetagamma-PI3K-PKCzeta cAMP pathway by RXFP1 is dependent upon the C-terminal 10 amino acids of the receptor and absolutely requires Arg(752).	Arginine	204-207	brain protein I3	Homo sapiens	59-68
18652489-4	2008	Ubiquitin"s Arg 72, which corresponds to Ala72 in the UBL NEDD8, is a key E1 selectivity determinant: swapping ubiquitin and NEDD8 residue 72 identity was shown previously to swap their E1 specificity.	Arginine	12-15	NEDD8 ubiquitin like modifier	Homo sapiens	58-63
18652489-4	2008	Ubiquitin"s Arg 72, which corresponds to Ala72 in the UBL NEDD8, is a key E1 selectivity determinant: swapping ubiquitin and NEDD8 residue 72 identity was shown previously to swap their E1 specificity.	Arginine	12-15	NEDD8 ubiquitin like modifier	Homo sapiens	125-130
18652489-6	2008	Here, we dissect this specificity with biochemical and X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 complexes in which NEDD8"s residue 72 and UBA3"s residue 190 are substituted with different combinations of Ala, Arg, or Gln.	Arginine	221-224	ubiquitin like modifier activating enzyme 3	Homo sapiens	97-101
21239484-3	2011	Arginine deficiency inhibited GH secretion and decreased liver Igf1 mRNA and plasma IGF1 concentration, but did not change muscle IGF1 concentration.	Arginine	0-8	insulin-like growth factor 1	Mus musculus	84-88
18652489-6	2008	Here, we dissect this specificity with biochemical and X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 complexes in which NEDD8"s residue 72 and UBA3"s residue 190 are substituted with different combinations of Ala, Arg, or Gln.	Arginine	221-224	NEDD8 ubiquitin like modifier	Homo sapiens	102-107
19127222-6	2009	In patient 2, we identified a novel missense mutation, c.1141G&gt;C, in exon 9, which led to a substitution of glycine with arginine in the TNFL domain of EDA (p.G381R).	Arginine	124-132	ectodysplasin A	Homo sapiens	155-158
21247217-2	2011	Previous studies have shown that peptides with an N-terminal Arg, especially peptides with the four-residue consensus sequence R/K/XXR/K, bind to NRP-1 cell surfaces.	Arginine	61-64	neuropilin 1	Homo sapiens	146-151
19216533-1	2009	Receptor interacting protein 140 (RIP140) undergoes extensive post-translational modifications (PTMs), including phosphorylation, acetylation, arginine methylation, and pyridoxylation.	Arginine	143-151	nuclear receptor interacting protein 1	Mus musculus	0-32
19216533-1	2009	Receptor interacting protein 140 (RIP140) undergoes extensive post-translational modifications (PTMs), including phosphorylation, acetylation, arginine methylation, and pyridoxylation.	Arginine	143-151	nuclear receptor interacting protein 1	Mus musculus	34-40
19216533-3	2009	Arginine methylation on Arg(240), Arg(650), and Arg(948) suppresses the repressive activity of RIP140.	Arginine	0-8	nuclear receptor interacting protein 1	Mus musculus	95-101
19216533-3	2009	Arginine methylation on Arg(240), Arg(650), and Arg(948) suppresses the repressive activity of RIP140.	Arginine	0-3	nuclear receptor interacting protein 1	Mus musculus	95-101
19216533-3	2009	Arginine methylation on Arg(240), Arg(650), and Arg(948) suppresses the repressive activity of RIP140.	Arginine	24-27	nuclear receptor interacting protein 1	Mus musculus	95-101
21146503-2	2011	The carboxylic acid group of the fatty acid was found to form a salt bridge with Arg(217) of HLE while unsaturation interacted with Phe(192) and Val(216) at the S(3) subsite, and alkyl end group occupied S(1) subsite.	Arginine	81-84	elastase, neutrophil expressed	Homo sapiens	93-96
19216533-3	2009	Arginine methylation on Arg(240), Arg(650), and Arg(948) suppresses the repressive activity of RIP140.	Arginine	24-27	nuclear receptor interacting protein 1	Mus musculus	95-101
19216533-8	2009	Kinetic analysis of PTMs of endogenous RIP140 in differentiated 3T3-L1 cells demonstrates sequential modifications on RIP140, initiated from constitutive lysine methylation, followed by increased arginine methylation later in differentiation.	Arginine	196-204	nuclear receptor interacting protein 1	Mus musculus	39-45
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Arginine	33-36	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	19-23
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Arginine	33-36	kringle containing transmembrane protein 1	Homo sapiens	110-116
18502762-5	2008	We were surprised to find that the Dkk1 mutants carrying a mutation at Arg(197), Ser(198), or Lys(232), the key Kremen-binding residues, could antagonize Wnt signaling as well as the wild-type Dkk1.	Arginine	71-74	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	35-39
18502762-5	2008	We were surprised to find that the Dkk1 mutants carrying a mutation at Arg(197), Ser(198), or Lys(232), the key Kremen-binding residues, could antagonize Wnt signaling as well as the wild-type Dkk1.	Arginine	71-74	kringle containing transmembrane protein 1	Homo sapiens	112-118
18703795-1	2009	Increasing evidence suggests that lung mechanics and structure are maintained in part by an intimate balance between the L-arginine-metabolizing enzymes nitric oxide synthase (NOS) and arginase.	Arginine	121-131	nitric oxide synthase 1, neuronal	Mus musculus	153-174
21204952-2	2011	The toxin binds to unidentified receptor(s) via 54 N-terminal amino acids, undergoes intramolecular cleavage on the C-terminal side of Arg(44) by furin or furin-like protease, and eventually enters the cytoplasm where the Rho GTPases reside.	Arginine	135-138	furin, paired basic amino acid cleaving enzyme	Homo sapiens	146-151
19017728-2	2009	Creatine synthesis requires three amino acids, methionine, glycine, and arginine, and two enzymes, l-arginine:glycine amidinotransferase (AGAT), which produces guanidinoacetate acid (GAA), and guanidinoacetate methyltransferase (GAMT), which methylates GAA to produce creatine.	Arginine	72-80	glycine amidinotransferase	Rattus norvegicus	138-142
18429990-9	2008	L-arginine also restored the level of eNOS and AP-1 activity.	Arginine	0-10	jun proto-oncogene	Mus musculus	47-51
18429990-13	2008	Furthermore, L-arginine also reversed the reduced AP-1 activity, an eNOS promoter.	Arginine	13-23	jun proto-oncogene	Mus musculus	50-54
21204952-2	2011	The toxin binds to unidentified receptor(s) via 54 N-terminal amino acids, undergoes intramolecular cleavage on the C-terminal side of Arg(44) by furin or furin-like protease, and eventually enters the cytoplasm where the Rho GTPases reside.	Arginine	135-138	furin, paired basic amino acid cleaving enzyme	Homo sapiens	155-160
21372816-6	2011	We have previously used this method to investigate the effect of arginine methylation of C/EBPbeta peptides.	Arginine	65-73	CCAAT enhancer binding protein beta	Homo sapiens	89-98
18436584-6	2008	LAP has a basic, arginine-rich C-terminal motif similar to VEGF and peptides that bind to the b1 domain of Nrp1.	Arginine	17-25	neuropilin 1	Homo sapiens	107-111
18596315-3	2008	We therefore hypothesized that arginine would enhance expression of MMP-2 in the postischemic gut.	Arginine	31-39	matrix metallopeptidase 2	Rattus norvegicus	68-73
18596315-8	2008	Pretreatment of the arginine group with a selective iNOS inhibitor blunted the induction of MMP-2 in the postischemic gut.	Arginine	20-28	matrix metallopeptidase 2	Rattus norvegicus	92-97
18596315-10	2008	CONCLUSIONS: The arginine-induced upregulation of iNOS may contribute to increased activity of MT1-MMP and MMP-2.	Arginine	17-25	matrix metallopeptidase 14	Rattus norvegicus	95-102
18596315-10	2008	CONCLUSIONS: The arginine-induced upregulation of iNOS may contribute to increased activity of MT1-MMP and MMP-2.	Arginine	17-25	matrix metallopeptidase 2	Rattus norvegicus	107-112
18948078-0	2009	Contribution of electrostatic and structural properties of Kv4.3 S4 arginine residues to the regulation of channel gating.	Arginine	68-76	potassium voltage-gated channel subfamily D member 3	Homo sapiens	59-64
18948078-1	2009	Previous work has demonstrated that replacing individual arginine (R) residues in the S4 domain of Kv4.3 with alanine (A) not only altered activation and deactivation processes, but also those of closed-state inactivation (CSI) and recovery.	Arginine	57-65	potassium voltage-gated channel subfamily D member 3	Homo sapiens	99-104
18948078-1	2009	Previous work has demonstrated that replacing individual arginine (R) residues in the S4 domain of Kv4.3 with alanine (A) not only altered activation and deactivation processes, but also those of closed-state inactivation (CSI) and recovery.	Arginine	67-68	potassium voltage-gated channel subfamily D member 3	Homo sapiens	99-104
18948078-10	2009	These results are consistent with the proposal that arginine residues in S4 are involved in regulating Kv4.3 CSI and recovery.	Arginine	52-60	potassium voltage-gated channel subfamily D member 3	Homo sapiens	103-108
20512387-2	2011	The PAs are synthesized by a metabolic process which involves arginase (ARG), which catalyzes the enzymatic hydrolysis of L-arginine (L-Arg) to L-ornithine and urea, and ornithine decarboxylase (ODC), which catalyzes the enzymatic decarboxylation of L-ornithine in putrescine.	Arginine	122-132	ornithine decarboxylase 1	Homo sapiens	195-198
18847325-1	2009	Carboxypeptidase Z (CPZ) removes carboxyl-terminal basic amino acid residues, particularly arginine residues, from proteins.	Arginine	91-99	carboxypeptidase Z	Rattus norvegicus	0-18
18847325-1	2009	Carboxypeptidase Z (CPZ) removes carboxyl-terminal basic amino acid residues, particularly arginine residues, from proteins.	Arginine	91-99	carboxypeptidase Z	Rattus norvegicus	20-23
18847325-4	2009	The Wnt-4 protein contains a C-terminal arginine residue and binds to CPZ through the CRD.	Arginine	40-48	carboxypeptidase Z	Rattus norvegicus	70-73
18847325-10	2009	Overexpression of CPZ in growth plate chondrocytes also removes the C-terminal arginine residue from a synthetic peptide consisting of the carboxyl-terminal 16 amino acids of the Wnt-4 protein.	Arginine	79-87	carboxypeptidase Z	Rattus norvegicus	18-21
18948357-5	2009	Arginine residues in TGase-1 were mutated in 39% (22/57) of patients overall and 54% (20/37) of those with missense mutations.	Arginine	0-8	transglutaminase 1	Homo sapiens	21-28
18467526-9	2008	Docking of GnRH I and GnRH II to the human GnRH receptor molecular model revealed that Arg(8) of GnRH I makes contact with Asp(302), whereas Tyr(8) of GnRH II appears to make different contacts, suggesting these residues stabilize different receptor conformations mediating differential intracellular signaling and effects on gonadotropin and cell growth.	Arginine	87-90	gonadotropin releasing hormone 2	Homo sapiens	22-29
18467526-9	2008	Docking of GnRH I and GnRH II to the human GnRH receptor molecular model revealed that Arg(8) of GnRH I makes contact with Asp(302), whereas Tyr(8) of GnRH II appears to make different contacts, suggesting these residues stabilize different receptor conformations mediating differential intracellular signaling and effects on gonadotropin and cell growth.	Arginine	87-90	gonadotropin releasing hormone receptor	Homo sapiens	43-56
18948357-12	2009	The high frequency of mutated arginine codons in TGM1 may be due to the deamination of CpG dinucleotides.	Arginine	30-38	transglutaminase 1	Homo sapiens	49-53
20512387-2	2011	The PAs are synthesized by a metabolic process which involves arginase (ARG), which catalyzes the enzymatic hydrolysis of L-arginine (L-Arg) to L-ornithine and urea, and ornithine decarboxylase (ODC), which catalyzes the enzymatic decarboxylation of L-ornithine in putrescine.	Arginine	134-139	ornithine decarboxylase 1	Homo sapiens	195-198
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Arginine	171-179	E1A binding protein p300	Homo sapiens	59-63
19004819-10	2009	Thus, Arg-55 also appears to be involved in enabling discrimination between the substrate and product in SDH.	Arginine	6-9	serine dehydratase	Homo sapiens	105-108
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Arginine	171-179	lysine acetyltransferase 2B	Homo sapiens	71-75
21416054-3	2011	Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants.	Arginine	171-179	Kruppel like factor 8	Homo sapiens	85-89
19028686-10	2009	These studies suggest that cathepsin K interaction with type I collagen is required for 1) the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2) termination of resorption via the creation of autocrine signals originating from type I collagen degradation.	Arginine	114-117	cathepsin K	Mus musculus	27-38
20872871-7	2011	The P37-metal interaction is drove by positively charged fragments of selected amino acids,mainly threonine 109, lysine 122, and arginine in positions 114 and 133.	Arginine	129-137	nucleoporin 37	Homo sapiens	4-7
19121451-1	2009	Nebivolol is a novel, beta1-adrenergic receptor blocker with vasodilatory properties mediated through the activation of the L-arginine/nitric oxide pathway.	Arginine	124-134	adrenoceptor beta 1	Homo sapiens	22-47
21258366-6	2011	Abolishment of Arg 1175 methylation enhances EGF-stimulated ERK activation by reducing SHP1 recruitment to EGFR, resulting in augmented cell proliferation, migration and invasion of EGFR-expressing cells.	Arginine	15-18	nuclear receptor subfamily 0 group B member 2	Homo sapiens	87-91
20966070-6	2011	Structural modeling highlights Ser-34 and Arg-98 as residues important for the assembly of the Myddosome, a death domain (DD) post-receptor complex involving the DD of MyD88, IRAK4, and IRAK2 or IRAK1.	Arginine	42-45	MYD88 innate immune signal transduction adaptor	Homo sapiens	168-173
18782082-7	2009	In contrast with all of the other GLX2 proteins characterized, GLX2-1 contains an arginine in place of one of the metal-binding histidine residues at position 246.	Arginine	82-90	glyoxalase 2-1	Arabidopsis thaliana	63-69
20966070-6	2011	Structural modeling highlights Ser-34 and Arg-98 as residues important for the assembly of the Myddosome, a death domain (DD) post-receptor complex involving the DD of MyD88, IRAK4, and IRAK2 or IRAK1.	Arginine	42-45	interleukin 1 receptor associated kinase 1	Homo sapiens	195-200
20844281-2	2011	Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.	Arginine	0-8	serine/threonine-protein kinase mTOR	Ovis aries	71-75
18955168-6	2009	Cells from both patients had a homozygous c.2T&gt;G mutation in the XPC gene which changed the ATG initiation codon to arginine (AGG).	Arginine	119-127	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	68-71
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Arginine	45-48	proteasome 20S subunit beta 9	Homo sapiens	77-81
20844281-7	2011	L-Arginine treatment increased the abundance of phosphorylated MTOR, RPS6K, and EIF4EBP1 in oTr cells.	Arginine	0-10	serine/threonine-protein kinase mTOR	Ovis aries	63-67
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Arginine	49-52	proteasome 20S subunit beta 9	Homo sapiens	77-81
20844281-7	2011	L-Arginine treatment increased the abundance of phosphorylated MTOR, RPS6K, and EIF4EBP1 in oTr cells.	Arginine	0-10	eukaryotic translation initiation factor 4E-binding protein 1	Ovis aries	80-88
19526842-2	2009	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphisms account 42.5 %, 46.4% and 11.1% correspondingly (in control--63.9%, 28.6%, 7.5%; P = 0.001 by c2-test).	Arginine	49-52	proteasome 20S subunit beta 9	Homo sapiens	77-81
20844281-11	2011	These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells.	Arginine	28-33	serine/threonine-protein kinase mTOR	Ovis aries	93-97
20844281-11	2011	These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells.	Arginine	28-33	serine/threonine-protein kinase mTOR	Ovis aries	98-103
20844282-8	2011	Arg, Leu, and glucose also stimulated increases in phosphorylated ribosomal protein S6K (pRPS6K) by 4.2-, 4.7-, and 2.3-fold, respectively, within 15 min, as well as increases in phosphorylated ribosomal protein S6 (pRPS6) between 0 and 30 min posttreatment, that were sustained to 60 min.	Arginine	0-3	ribosomal protein S6	Homo sapiens	66-86
19247493-9	2009	The N/N-LOX-1 mutant has either interrupted electrostatic potential and asymmetric fluctuations of the basic spine arginines.	Arginine	115-124	oxidized low density lipoprotein receptor 1	Homo sapiens	8-13
21591931-6	2011	Another was found to be a truncated form of LOX resulting from the cleavage at the carboxy terminus of Arg(192).	Arginine	103-106	lysyl oxidase	Mus musculus	44-47
18756523-2	2008	The Glycine (Gly) to Arginine (Arg) polymorphism at codon 388 (Gly388Arg), which encodes an amino acid in the transmembrane part of the FGFR4 gene, was reported to be associated with an increased risk in some carcinomas.	Arginine	21-29	fibroblast growth factor receptor 4	Homo sapiens	136-141
18756523-2	2008	The Glycine (Gly) to Arginine (Arg) polymorphism at codon 388 (Gly388Arg), which encodes an amino acid in the transmembrane part of the FGFR4 gene, was reported to be associated with an increased risk in some carcinomas.	Arginine	21-24	fibroblast growth factor receptor 4	Homo sapiens	136-141
18756523-7	2008	Our results indicate that the FGFR4 Arg allele of the Gly388Arg polymorphism and the G allele of the rs2011077 polymorphism have a significant impact on the development of prostate cancer and BPH, and the progression of prostate cancer in a Japanese population.	Arginine	36-39	fibroblast growth factor receptor 4	Homo sapiens	30-35
21304263-2	2011	This biological activity of OPN may be attributed to its characteristic structure, which includes 2 calcium binding sites, Arg-Gly-Asp (RGD) sequences.	Arginine	123-126	secreted phosphoprotein 1	Mus musculus	28-31
19704448-1	2008	Arg catabolism to cytoplasmic urea and glutamate is initiated by two mitochondrial enzymes, arginase and ornithine aminotransferase.	Arginine	0-3	ornithine aminotransferase	Homo sapiens	92-131
21143647-3	2011	HYPOTHESIS: Diabetic cats with and without remission will have different arginine-induced insulin or glucagon response.	Arginine	73-81	insulin	Felis catus	90-97
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	interferon alpha 2	Homo sapiens	35-45
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	interferon alpha 2	Homo sapiens	54-64
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	interferon alpha 2	Homo sapiens	54-64
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	interferon alpha 2	Homo sapiens	54-64
21143647-14	2011	CONCLUSIONS AND CLINICAL IMPORTANCE: Diabetic cats with and without remission have similar arginine-stimulated insulin secretion on admission.	Arginine	91-99	insulin	Felis catus	111-118
21897744-0	2011	Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice.	Arginine	23-33	solute carrier family 23 member 2	Homo sapiens	92-98
18988736-6	2008	It is proposed that, in both cases, a protonated basic residue (Arg-37 in the case of human UroD; Lys-93 in the case of yeast ODCase) furnishes a counterion that helps the scissile carboxylate group of the substrate leave water and enter a relatively nonpolar environment, stabilizes the incipient carbanion generated by the departure of CO(2), and supplies the proton that takes its place.	Arginine	64-67	uroporphyrinogen decarboxylase	Homo sapiens	92-96
21897744-6	2011	RESULTS: In hSVCT2 mice, L-arginine decreased 335/385 and 370/440 nm fluorescence by 40% (p&lt;0.001), CML, CEL, and glucosepane crystallin crosslinks by 35% (p&lt;0.05), 30% (p&lt;0.05), and 37% (p&lt;0.05), respectively, without affecting MG-H1 and G-H1.	Arginine	25-35	solute carrier family 23 member 2	Homo sapiens	12-18
18728015-3	2008	According to the Na(+)/K(+)-ATPase crystal structure, a subset of the mutated residues (Ala(606), Arg(763), Met(829), and Arg(834)) is involved in important interdomain H-bond networks, and the C terminus of the enzyme, which is elongated by the X1021R mutation, has been implicated in voltage dependence and formation of a third Na(+)-binding site.	Arginine	98-101	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	17-34
22028839-7	2011	Site-directed mutagenesis of this helix A motif in PEDF resulted in a GFP-tagged mutant protein being excluded from the nucleus, and mutation of two arginine residues (R67, R69) was sufficient to abolish nuclear import and PEDF interaction with transportin-SR2.	Arginine	149-157	serpin family F member 1	Homo sapiens	51-55
18728015-3	2008	According to the Na(+)/K(+)-ATPase crystal structure, a subset of the mutated residues (Ala(606), Arg(763), Met(829), and Arg(834)) is involved in important interdomain H-bond networks, and the C terminus of the enzyme, which is elongated by the X1021R mutation, has been implicated in voltage dependence and formation of a third Na(+)-binding site.	Arginine	122-125	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	17-34
21829689-5	2011	Substitution of either K(159) or K(279) with arginine reduced DEC1 SUMOylation, but substitution of both K(159) and K(279) abolished SUMOylation, and more protein appeared to be retained in the cytoplasm compared to wild-type DEC1.	Arginine	45-53	deleted in esophageal cancer 1	Homo sapiens	62-66
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Arginine	287-299	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Arginine	287-299	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18786176-4	2008	Western blot analysis of pertinent signal transduction components revealed both enhanced phosphorylation of early signaling intermediates upon co-stimulation, and a LN-induced down-regulation of p75NTR which could be prevented by the addition of integrin inhibitory arginine-glycine-aspartate (RGD) peptides.	Arginine	266-274	nerve growth factor receptor	Rattus norvegicus	195-201
18765660-3	2008	One at Arg(320) yields the proteinase meizothrombin that retains membrane binding properties.	Arginine	7-10	endogenous retrovirus group K member 21, envelope	Homo sapiens	27-37
18413672-3	2008	As we have demonstrated before, these effects are mediated in part through inhibition of neuronal nitric oxide synthase (nNOS), resulting in increased availability of arginine.	Arginine	167-175	nitric oxide synthase 1, neuronal	Mus musculus	89-119
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Arginine	50-58	interleukin 9	Homo sapiens	18-21
20937841-3	2010	Proteolytic cleavage of the Arg(494)-Val(495) peptide bond in the zymogen-like pro-HGF results in allosteric activation of the serine protease-like beta-chain (HGF beta), which binds Met to initiate signaling.	Arginine	28-31	hepatocyte growth factor	Homo sapiens	83-86
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Arginine	50-58	interleukin 9	Homo sapiens	186-189
20937841-3	2010	Proteolytic cleavage of the Arg(494)-Val(495) peptide bond in the zymogen-like pro-HGF results in allosteric activation of the serine protease-like beta-chain (HGF beta), which binds Met to initiate signaling.	Arginine	28-31	hepatocyte growth factor	Homo sapiens	160-168
18614796-0	2008	Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.	Arginine	82-90	Secretory 16	Drosophila melanogaster	11-16
18614796-0	2008	Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.	Arginine	82-90	Secretion-associated Ras-related 1	Drosophila melanogaster	66-70
18591903-3	2008	The purpose of the present study is to assess the clinical effects of real life usage of beta2-agonist (long-acting beta2-agonist, regular use of short-acting beta2 agonist, or oral beta2-agonist), as an add-on medication to inhaled steroids, in Arg/Arg and Gly/Gly patients with asthma.	Arginine	246-249	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-94
21502714-2	2010	The plasma brain natriuretic peptide (BNP) level inversely correlated with the plasma concentration of L-arginine.	Arginine	103-113	natriuretic peptide B	Homo sapiens	11-36
18591903-3	2008	The purpose of the present study is to assess the clinical effects of real life usage of beta2-agonist (long-acting beta2-agonist, regular use of short-acting beta2 agonist, or oral beta2-agonist), as an add-on medication to inhaled steroids, in Arg/Arg and Gly/Gly patients with asthma.	Arginine	250-253	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-94
18591903-8	2008	CONCLUSION: Gly/Gly and Arg/Arg genotype responses to regular usage of beta2-agonists may differ in patients with asthma.	Arginine	24-27	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	71-76
18591903-8	2008	CONCLUSION: Gly/Gly and Arg/Arg genotype responses to regular usage of beta2-agonists may differ in patients with asthma.	Arginine	28-31	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	71-76
18614796-5	2008	Last, we show that the dSec16 domain required for its localization maps to an arginine-rich motif located in a nonconserved region.	Arginine	78-86	Secretory 16	Drosophila melanogaster	23-29
18614796-6	2008	We propose a model in which dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles, thus acting as a tER scaffold.	Arginine	57-65	Secretory 16	Drosophila melanogaster	28-34
18614796-6	2008	We propose a model in which dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles, thus acting as a tER scaffold.	Arginine	57-65	Secretion-associated Ras-related 1	Drosophila melanogaster	94-98
18275628-7	2008	The 0.5 % Arg prevented the elevation of jejunal IL-6 mRNA abundance (P = 0.082), and jejunal (P = 0.030) and ileal (P = 0.039) TNF-alpha mRNA abundance induced by LPS challenge.	Arginine	10-13	interleukin 6	Sus scrofa	49-53
18339325-0	2008	The nuclear localization of Drosophila Hsp27 is dependent on a monopartite arginine-rich NLS and is uncoupled from its association to nuclear speckles.	Arginine	75-83	Heat shock protein 27	Drosophila melanogaster	39-44
21502714-2	2010	The plasma brain natriuretic peptide (BNP) level inversely correlated with the plasma concentration of L-arginine.	Arginine	103-113	natriuretic peptide B	Homo sapiens	38-41
18275628-7	2008	The 0.5 % Arg prevented the elevation of jejunal IL-6 mRNA abundance (P = 0.082), and jejunal (P = 0.030) and ileal (P = 0.039) TNF-alpha mRNA abundance induced by LPS challenge.	Arginine	10-13	tumor necrosis factor	Sus scrofa	128-137
20845493-7	2010	Modification of the CPC with arginine and aspartic acid, but not with cocarboxylase, led to a higher BMP-2 binding.	Arginine	29-37	bone morphogenetic protein 2	Homo sapiens	101-106
18275628-8	2008	The 1.0 % Arg alleviated the elevation of jejunal IL-6 mRNA abundance (P = 0.053) and jejunal TNF-alpha mRNA abundance (P = 0.003) induced by LPS challenge.	Arginine	10-13	interleukin 6	Sus scrofa	50-54
18275628-8	2008	The 1.0 % Arg alleviated the elevation of jejunal IL-6 mRNA abundance (P = 0.053) and jejunal TNF-alpha mRNA abundance (P = 0.003) induced by LPS challenge.	Arginine	10-13	tumor necrosis factor	Sus scrofa	94-103
18381083-6	2008	A lysine or arginine in the P+1 position on the C-terminal side of the phosphoacceptor threonine (P site) was found to be critical for peptide substrate recognition by MHCK A, MHCK B and eEF-2K.	Arginine	12-20	eukaryotic elongation factor 2 kinase	Homo sapiens	187-193
18371313-2	2008	The intermediate N(omega)-hydroxy-L-arginine (NHA) has a larger affinity than L-Arginine (L-Arg) for nNOS(oxy), with K(d)=0.4+/-0.1 microM and 1.7+/-0.3 microM at 25 degrees C, respectively.	Arginine	78-88	nitric oxide synthase 1	Homo sapiens	101-105
18652916-6	2008	This suggests that HLA-DPB1 alleles with arginine may be associated with protection against development of PTB in both HIV infected as well as uninfected individuals.	Arginine	41-49	major histocompatibility complex, class II, DP beta 1	Homo sapiens	23-27
18371313-2	2008	The intermediate N(omega)-hydroxy-L-arginine (NHA) has a larger affinity than L-Arginine (L-Arg) for nNOS(oxy), with K(d)=0.4+/-0.1 microM and 1.7+/-0.3 microM at 25 degrees C, respectively.	Arginine	78-83	nitric oxide synthase 1	Homo sapiens	101-105
20966198-3	2010	Both RNPS1 and Acinus contain typical motifs of splicing regulatory proteins including arginine/serine-rich domains.	Arginine	87-95	RNA binding protein with serine rich domain 1	Homo sapiens	5-10
18371313-3	2008	nNOS(oxy) binds NHA and L-Arg with DeltaH -4.1+/-0.2 and -1.0+/-0.1 kcal/mol and DeltaS=15 and 23 cal/Kmol respectively.	Arginine	24-29	nitric oxide synthase 1	Homo sapiens	0-4
18573508-1	2008	In the present study, genotype and haplotype frequencies of four polymorphisms of cytochrome P450 1B1 (CYP1B1) that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at 432 and Asn-Ser at codon 453) were studied in 200 patients suffering from lung cancer and equal number of controls.	Arginine	142-145	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	82-101
18573508-1	2008	In the present study, genotype and haplotype frequencies of four polymorphisms of cytochrome P450 1B1 (CYP1B1) that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at 432 and Asn-Ser at codon 453) were studied in 200 patients suffering from lung cancer and equal number of controls.	Arginine	142-145	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	103-109
20214496-2	2010	Lupin is a source of polyphenols, protein, and L-arginine, factors that may influence blood pressure via effects on oxidative stress and vascular function.	Arginine	47-57	5'-nucleotidase, cytosolic IIIA	Homo sapiens	0-5
18481277-8	2008	Our data for the first time demonstrate that not only saposin C or PSAP regulates AR expression/activity, but also function as an ARG in PrSt.	Arginine	130-133	solute carrier family 45 member 3	Homo sapiens	137-141
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	105-108	serine peptidase inhibitor Kazal type 5	Homo sapiens	26-31
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	105-108	serine peptidase inhibitor Kazal type 5	Homo sapiens	123-128
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	105-108	plasminogen	Homo sapiens	143-150
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	105-108	furin, paired basic amino acid cleaving enzyme	Homo sapiens	260-265
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	178-181	serine peptidase inhibitor Kazal type 5	Homo sapiens	26-31
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	178-181	serine peptidase inhibitor Kazal type 5	Homo sapiens	123-128
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	178-181	plasminogen	Homo sapiens	143-150
17989726-7	2008	Predominant inhibition by LEKTI domains against overall SC protease activities was trypsin-like (Phe-Ser-Arg-) activity by LEKTI domains 6-12, plasmin- and trypsin-like (Pro-Phe-Arg-) activities by domains 12-15, chymotrypsin-like activity by all domains, and furin-like activity by none.	Arginine	178-181	furin, paired basic amino acid cleaving enzyme	Homo sapiens	260-265
18424593-6	2008	Arginine supplementation increased (P &lt; 0.05) daily gain, the plasma insulin concentration, and protein synthesis in skeletal muscle but not in liver.	Arginine	0-8	insulin	Sus scrofa	72-79
18347055-3	2008	The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180, and arginine substitution of these residues impaired IL-1R/TLR-mediated IRAK-1 ubiquitination, NEMO binding, and NF-kappaB activation.	Arginine	73-81	interleukin 1 receptor associated kinase 1	Homo sapiens	141-147
18201743-5	2008	Mutation analyses revealed that all of the residues in the Walker A motif (Gly(199), Lys(200) and Thr(201)), in addition to the polar residues within the NTP-binding pocket (Gln(457), Arg(461) and Arg(464)), and also Arg(458) in the outside of the pocket in the motif IV were crucial for ATPase and helicase activities and virus replication.	Arginine	184-187	dynein axonemal heavy chain 8	Homo sapiens	288-294
18201743-5	2008	Mutation analyses revealed that all of the residues in the Walker A motif (Gly(199), Lys(200) and Thr(201)), in addition to the polar residues within the NTP-binding pocket (Gln(457), Arg(461) and Arg(464)), and also Arg(458) in the outside of the pocket in the motif IV were crucial for ATPase and helicase activities and virus replication.	Arginine	184-187	helicase for meiosis 1	Homo sapiens	299-307
18380667-3	2008	The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure.	Arginine	65-73	guanidinoacetate N-methyltransferase	Rattus norvegicus	112-146
18380667-3	2008	The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure.	Arginine	65-73	guanidinoacetate N-methyltransferase	Rattus norvegicus	148-152
18061232-6	2008	Interestingly, Vpr was found to undergo proteolytic processing at a very well conserved proprotein convertase (PC) cleavage site, R(85)QRR(88) downward arrow, located within the functionally important C-terminal arginine-rich domain of the protein.	Arginine	212-220	Vpr	Human immunodeficiency virus 1	15-18
18156200-3	2008	Among several transporters that mediate L-arginine uptake, cationic amino acid transporter-1 (CAT-1) acts as the specific arginine transporter for endothelial NO synthase.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	59-92
18156200-3	2008	Among several transporters that mediate L-arginine uptake, cationic amino acid transporter-1 (CAT-1) acts as the specific arginine transporter for endothelial NO synthase.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	94-99
18156200-10	2008	In conclusion, aortic arginine uptake is reduced during pregnancy, through posttranslational modulation of CAT-1 protein, presumably via upregulation of PKC-alpha.	Arginine	22-30	solute carrier family 7 member 1	Rattus norvegicus	107-112
18316480-7	2008	These arginine methylation sites and the dynamic regulation of corepressor binding are lost in the leukemia-associated RUNX1-ETO fusion protein, which likely contributes to its dominant inhibitory activity.	Arginine	6-14	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	125-128
18172665-2	2008	Moreover, we tested the hypothesis that L -arginine and L -ornithine influence the expression and synthesis of hCAT1 and hCAT2 in cell culture experiments by means of real-time-PCR and Western blot.	Arginine	40-51	solute carrier family 7 member 2	Homo sapiens	121-126
18172665-5	2008	In contrast, L -arginine concentrations of 2 mM led to a significant increase of the hCAT2B mRNA-expression after 24 h. However, 48 and 72 h revealed no significant changes and high concentrations (15 mM L -arginine) led to a significant downregulation of the hCAT2B transporter over all time points analyzed.	Arginine	13-24	solute carrier family 7 member 2	Homo sapiens	85-90
18172665-5	2008	In contrast, L -arginine concentrations of 2 mM led to a significant increase of the hCAT2B mRNA-expression after 24 h. However, 48 and 72 h revealed no significant changes and high concentrations (15 mM L -arginine) led to a significant downregulation of the hCAT2B transporter over all time points analyzed.	Arginine	204-215	solute carrier family 7 member 2	Homo sapiens	85-90
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Arginine	137-140	gonadotropin releasing hormone receptor	Homo sapiens	74-113
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Arginine	137-140	gonadotropin releasing hormone receptor	Homo sapiens	115-120
18319619-1	2008	The Glu/Asp(7.32) residue in extracellular loop 3 of the mammalian type-I gonadotropin-releasing hormone receptor (GnRHR) interacts with Arg(8) of GnRH-I, conferring preferential ligand selectivity for GnRH-I over GnRH-II.	Arginine	137-140	gonadotropin releasing hormone 2	Homo sapiens	214-221
18272676-10	2008	Mutations of A651(NR2B) into arginine, tryptophan, or phenylalanine, and similar mutations of the corresponding A652 in NR1 also lead to constitutively open channels.	Arginine	29-37	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	18-22
18039921-2	2008	Therefore, our studies centered on a viral protein, the NS3 helicase, whose activity is indispensable for replication of the viral RNA, and on its peptide inhibitor that corresponds to a highly conserved arginine-rich sequence of domain 2 of the helicase.	Arginine	204-212	helicase for meiosis 1	Homo sapiens	246-254
18082150-0	2008	Detection of local polarity and conformational changes at the active site of rabbit muscle creatine kinase with a new arginine-specific fluorescent probe.	Arginine	118-126	creatine kinase M-type	Oryctolagus cuniculus	84-106
17984098-0	2008	Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.	Arginine	11-19	acid-sensing (proton-gated) ion channel 1	Mus musculus	95-101
20641499-1	2004	(99m)Tc-(Arg(11))CCMSH is an alpha-melanocyte-stimulating hormone (MSH) peptide labeled with (99m)Tc, a gamma emitter with a physical t1/2 of 6 h. Malignant melanoma is the sixth most common cancer in the United States (1).	Arginine	9-12	pro-opiomelanocortin-alpha	Mus musculus	29-65
17765926-4	2008	Sequence analysis of TITF-1 revealed the presence of a heterozygous C&gt;T substitution at nucleotide 532, predicted to change an arginine (CGA) with a stop codon (TGA) at position 178 (R178X).	Arginine	130-138	T-box transcription factor 1	Homo sapiens	164-167
18052254-0	2008	Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.	Arginine	79-89	nitric oxide synthase 1	Homo sapiens	44-48
18052254-1	2008	Fully coupled nitric oxide synthase (NOS) catalyzes formation of nitric oxide (NO), l-citrulline, NADP+, and water from l-arginine, NADPH, and oxygen.	Arginine	120-130	nitric oxide synthase 1	Homo sapiens	14-35
18052254-14	2008	The regulatory role of l-arginine in nNOS is thus very different from that in eNOS where substrate was only to decrease the rate of formation of superoxide but not the total amount of radical.	Arginine	23-33	nitric oxide synthase 1	Homo sapiens	37-41
17934065-11	2008	TGF-beta1-induced upregulation of arginase-1 suggests an interplay between profibrotic agents and l-arginine metabolism during the course of lung fibrosis in the mouse, whereas species-specific regulatory mechanisms may account for the differences observed in mouse and human.	Arginine	98-108	transforming growth factor, beta 1	Mus musculus	0-9
17934065-11	2008	TGF-beta1-induced upregulation of arginase-1 suggests an interplay between profibrotic agents and l-arginine metabolism during the course of lung fibrosis in the mouse, whereas species-specific regulatory mechanisms may account for the differences observed in mouse and human.	Arginine	98-108	arginase, liver	Mus musculus	34-44
17845003-2	2008	Both integrins and APN recognize a broad range of peptides containing RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, respectively.	Arginine	105-108	alanyl aminopeptidase, membrane	Homo sapiens	19-22
18296272-5	2008	In cold-acclimated control and L-NAME treated rats leptin immunopositivity was absent, while L-arginine treatment reversed the cold-induced suppression of leptin expression.	Arginine	93-103	leptin	Rattus norvegicus	155-161
18296272-7	2008	In conclusion, L-arginine treatment changes leptin expression pattern on cold in rat IBAT.	Arginine	15-25	leptin	Rattus norvegicus	44-50
18554543-1	2008	Nitric oxide (NO) and carbon monoxide (CO) are synthesized from l-arginine and heme by the catalytic reaction of NO synthase (NOS) and heme oxygenase (HO).	Arginine	64-74	nitric oxide synthase 1, neuronal	Mus musculus	113-124
17828581-5	2008	The first and second serine-and arginine-rich regions of DOA are required for the interaction between DOA and DX16.	Arginine	32-40	x16 splicing factor	Drosophila melanogaster	110-114
17942747-2	2008	Molecular modeling and ligand docking to previously experimentally identified binding sites revealed a putative novel interaction between the C terminus of gonadotropin-releasing hormone (GnRH) and Arg(38(1.35)), located at the extracellular end of transmembrane domain 1 of the human GnRH receptor.	Arginine	198-201	gonadotropin releasing hormone 1	Homo sapiens	156-186
17942747-2	2008	Molecular modeling and ligand docking to previously experimentally identified binding sites revealed a putative novel interaction between the C terminus of gonadotropin-releasing hormone (GnRH) and Arg(38(1.35)), located at the extracellular end of transmembrane domain 1 of the human GnRH receptor.	Arginine	198-201	gonadotropin releasing hormone 1	Homo sapiens	188-192
17942747-2	2008	Molecular modeling and ligand docking to previously experimentally identified binding sites revealed a putative novel interaction between the C terminus of gonadotropin-releasing hormone (GnRH) and Arg(38(1.35)), located at the extracellular end of transmembrane domain 1 of the human GnRH receptor.	Arginine	198-201	gonadotropin releasing hormone receptor	Homo sapiens	285-298
17942747-3	2008	Mutation of Arg(38(1.35)) to alanine resulted in 989- and 1268-fold reduction in affinity for GnRH I and GnRH II, respectively, the two endogenous ligands.	Arginine	12-15	gonadotropin releasing hormone 1	Homo sapiens	94-98
17942747-3	2008	Mutation of Arg(38(1.35)) to alanine resulted in 989- and 1268-fold reduction in affinity for GnRH I and GnRH II, respectively, the two endogenous ligands.	Arginine	12-15	gonadotropin releasing hormone 2	Homo sapiens	105-112
17942747-4	2008	Conservative mutation of Arg(38(1.35)) to lysine had less effect, giving reduced affinities of GnRH I and GnRH II by 24- and 54-fold, respectively.	Arginine	25-28	gonadotropin releasing hormone 1	Homo sapiens	95-99
17942747-4	2008	Conservative mutation of Arg(38(1.35)) to lysine had less effect, giving reduced affinities of GnRH I and GnRH II by 24- and 54-fold, respectively.	Arginine	25-28	gonadotropin releasing hormone 2	Homo sapiens	106-113
17942747-5	2008	To test whether Arg(38(1.35)) interacts with the C-terminal Gly(10)-NH(2) of GnRH, binding of GnRH analogs with substitution of the C-terminal glycinamide with ethylamide ([Pro(9)-NHEt]GnRH) was studied with wild-type and Arg(38(1.35)) mutant receptors.	Arginine	16-19	gonadotropin releasing hormone 1	Homo sapiens	77-81
17942747-6	2008	Mutation of Arg(38(1.35)) to lysine or alanine had much smaller effect on receptor affinity for [Pro(9)-NHEt]GnRH analogs and no effect on binding affinity of peptide antagonist cetrorelix.	Arginine	12-15	gonadotropin releasing hormone 1	Homo sapiens	109-113
17942747-9	2008	These findings indicate that Arg(38(1.35)) of the GnRH receptor is essential for high-affinity binding of GnRH agonists and stabilizing the receptor active conformation.	Arginine	29-32	gonadotropin releasing hormone receptor	Homo sapiens	50-63
17942747-9	2008	These findings indicate that Arg(38(1.35)) of the GnRH receptor is essential for high-affinity binding of GnRH agonists and stabilizing the receptor active conformation.	Arginine	29-32	gonadotropin releasing hormone 1	Homo sapiens	50-54
17971302-5	2007	Inhibition of arginine methylation with MTA or PRMT1-siRNA diminished later phase of insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and IRS-1, association of IRS-1 with p85alpha subunit of PI3-K, and glucose uptake.	Arginine	14-22	peptidase inhibitor 3	Homo sapiens	216-219
17823309-4	2007	Here, we identified a polyproline-arginine sequence in the human pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85/CMS family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS, CIN85, and CD2BP3) members.	Arginine	34-42	pre T cell antigen receptor alpha	Homo sapiens	65-72
18393942-4	2008	Plasmid-shuffling analysis revealed that Asn(600), Arg(694) and Arg(704) are essential for the function of Orc1p.	Arginine	51-54	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	107-112
18393942-4	2008	Plasmid-shuffling analysis revealed that Asn(600), Arg(694) and Arg(704) are essential for the function of Orc1p.	Arginine	64-67	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	107-112
18393942-6	2008	In vitro, purified ORC-1R [ORC with Orc1R694Ep (Orc1p Arg(694)--&gt;Glu mutant)] has decreased ATPase activity in the presence or absence of origin DNA.	Arginine	54-57	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	48-53
18393942-8	2008	The present study showed that Arg(694) of the Orc1p subunit is important for the ATPase activity of ORC and suggests that this ATPase activity is required for efficient MCM loading on to origin DNA and for progression of S phase.	Arginine	30-33	origin recognition complex subunit 1	Saccharomyces cerevisiae S288C	46-51
18628823-0	2008	PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation.	Arginine	22-30	nuclear receptor interacting protein 1	Homo sapiens	46-52
18628823-2	2008	Previously we identified three methylated arginine residues in RIP140, which rendered its export to the cytoplasm; but it was unclear what triggered RIP140 arginine methylation.	Arginine	42-50	nuclear receptor interacting protein 1	Homo sapiens	63-69
18628823-2	2008	Previously we identified three methylated arginine residues in RIP140, which rendered its export to the cytoplasm; but it was unclear what triggered RIP140 arginine methylation.	Arginine	156-164	nuclear receptor interacting protein 1	Homo sapiens	63-69
18628823-3	2008	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we determined the activated PKCepsilon as the specific trigger for RIP140 arginine methylation and its subsequent export.	Arginine	121-129	nuclear receptor interacting protein 1	Homo sapiens	114-120
18628823-8	2008	CONCLUSIONS/SIGNIFICANCE: This study uncovers a novel means, via a cascade of protein modifications, to inactivate, or suppress, the nuclear action of an important transcription coregulator RIP140, and delineates the first specific phosphorylation-arginine methylation cascade that could alter protein subcellular distribution and biological activity.	Arginine	248-256	nuclear receptor interacting protein 1	Homo sapiens	190-196
18468516-4	2008	Drosophila arginine methyltransferase 1 (DART1), the mammalian PRMT1 homologue, methylates the arginine residue of histone H4 (H4R3me2).	Arginine	11-19	Arginine methyltransferase 1	Drosophila melanogaster	41-46
18480054-10	2008	While Arg(11) of ADWX-1 interacts with Asp(386) in Kv1.3, Thr(28) and His(33) of ADWX-1 locate right above the selectivity filter-S6 linker of Kv1.3.	Arginine	6-9	potassium voltage-gated channel subfamily A member 3	Homo sapiens	51-56
18480054-10	2008	While Arg(11) of ADWX-1 interacts with Asp(386) in Kv1.3, Thr(28) and His(33) of ADWX-1 locate right above the selectivity filter-S6 linker of Kv1.3.	Arginine	6-9	potassium voltage-gated channel subfamily A member 3	Homo sapiens	143-148
18456737-4	2008	Arginine treatment of BERK mice (5% arginine in mouse chow for 15 days) significantly reduced expression of non-NO vasodilators COX-2 and heme oxygenase-1.	Arginine	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	128-133
18456737-4	2008	Arginine treatment of BERK mice (5% arginine in mouse chow for 15 days) significantly reduced expression of non-NO vasodilators COX-2 and heme oxygenase-1.	Arginine	36-44	cytochrome c oxidase II, mitochondrial	Mus musculus	128-133
18458097-2	2008	Recently, the use of L-arginine, the substrate of nitric oxide synthase (nNOS), has been proposed as a pharmacological treatment to attenuate the dystrophic pattern of DMD.	Arginine	21-31	nitric oxide synthase 1, neuronal	Mus musculus	73-77
18458097-9	2008	We show that the inhibitory effect of L-arginine on the NF-kappaB/MMP cascade reduces beta-dystroglycan cleavage and translocates utrophin and nNOS throughout the sarcolemma.	Arginine	38-48	nitric oxide synthase 1, neuronal	Mus musculus	143-147
18215125-13	2008	Recombinant neurobin processed 17-kDa FGF-2 (fibroblast growth factor-2) at several P(1) lysine and arginine positions to distinct fragments, in a heparin-inhibitable manner, but did not cleave FGF-7, laminin or fibronectin.	Arginine	100-108	fibroblast growth factor 2	Mus musculus	38-43
18215125-13	2008	Recombinant neurobin processed 17-kDa FGF-2 (fibroblast growth factor-2) at several P(1) lysine and arginine positions to distinct fragments, in a heparin-inhibitable manner, but did not cleave FGF-7, laminin or fibronectin.	Arginine	100-108	fibroblast growth factor 2	Mus musculus	45-71
18353876-0	2008	L-arginine-induced glomerular hyperfiltration response: the roles of insulin and ANG II.	Arginine	0-10	angiogenin	Homo sapiens	81-84
18355840-9	2008	In p53 codon72 Arg/Pro + Pro/Pro carriers the frequency of the AG + GG genotype of MSH3 exon23 was significantly increased in patients compared to controls (OR 2.1, 95% CI 1.05-4.34).	Arginine	15-18	mutS homolog 3	Homo sapiens	83-87
18318467-0	2008	Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors.	Arginine	0-8	galectin 3	Homo sapiens	88-98
18227067-2	2008	Both intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels have two conserved arginines in S4 and a single conserved glutamic acid in S3, although these channels are voltage-independent.	Arginine	109-118	potassium calcium-activated channel subfamily N member 4	Homo sapiens	19-25
18227067-4	2008	Mutation of the S4 arginine closest to the cytosolic side of KCa3.1 to histidine resulted in expression at the cell surface.	Arginine	19-27	potassium calcium-activated channel subfamily N member 4	Homo sapiens	61-67
18335928-4	2008	The arginine of the E/DRY motif is predicted to be an important mediator of the intramolecular and intermolecular communication involving the TXA2R.	Arginine	4-12	thromboxane A2 receptor	Homo sapiens	142-147
18392324-3	2008	In contrast to thrombin, which has a preference toward arginine residues, human neutrophil elastase (HNE) cleaves peptide bonds at small side-chain aliphatic amino acids, preferably at valine.	Arginine	55-63	elastase, neutrophil expressed	Homo sapiens	80-99
18392324-3	2008	In contrast to thrombin, which has a preference toward arginine residues, human neutrophil elastase (HNE) cleaves peptide bonds at small side-chain aliphatic amino acids, preferably at valine.	Arginine	55-63	elastase, neutrophil expressed	Homo sapiens	101-104
18369473-1	2008	Cationic amino acid transporters (CAT) are important regulators of NOS2 and ARG1 activity because they regulate L-arginine availability.	Arginine	112-122	arginase, liver	Mus musculus	76-80
18331634-6	2008	Patients with the ADRB1 Gly389 polymorphism were at higher risk for the composite outcome due to higher rates of myocardial infarction (adjusted hazard ratio [HR] 3.63, 95% confidence interval [95%CI] 1.17-11.28; Gly/Gly vs. Arg/Arg HR 4.14, 95%CI 0.88-19.6).	Arginine	225-228	adrenoceptor beta 1	Homo sapiens	18-23
18331634-6	2008	Patients with the ADRB1 Gly389 polymorphism were at higher risk for the composite outcome due to higher rates of myocardial infarction (adjusted hazard ratio [HR] 3.63, 95% confidence interval [95%CI] 1.17-11.28; Gly/Gly vs. Arg/Arg HR 4.14, 95%CI 0.88-19.6).	Arginine	229-232	adrenoceptor beta 1	Homo sapiens	18-23
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	adenylate cyclase activating polypeptide 1	Homo sapiens	60-65
18425618-2	2008	A missense mutation causing the replacement of the corresponding residues with an arginine (W309R) occurs in KCNQ3 subunits forming part of M-channels.	Arginine	82-90	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	109-114
18067928-2	2008	In the present study, genotype and haplotype frequencies of four single nucleotide polymorphisms (SNPs) in CYP1B1 that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at codon 432 and Asn-Ser at codon 453) were studied in 150 cases suffering from head and neck squamous cell carcinoma (HNSCC) and in an equal number of controls.	Arginine	145-148	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
18223652-6	2008	MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function.	Arginine	30-38	MALT1 paracaspase	Homo sapiens	0-5
18264101-3	2008	Here we report that MALT1 had arginine-directed proteolytic activity that was activated after T cell stimulation, and we identify the signaling protein Bcl-10 as a MALT1 substrate.	Arginine	30-38	MALT1 paracaspase	Homo sapiens	20-25
18264101-3	2008	Here we report that MALT1 had arginine-directed proteolytic activity that was activated after T cell stimulation, and we identify the signaling protein Bcl-10 as a MALT1 substrate.	Arginine	30-38	BCL10 immune signaling adaptor	Homo sapiens	152-158
18058820-10	2008	Altogether, this study provides evidence for an association of variants in the NOS1 gene and RLS, and suggests the involvement of the NO/arginine pathway in the pathogenesis of RLS.	Arginine	137-145	nitric oxide synthase 1	Homo sapiens	79-83
18301339-2	2008	Single nucleotide polymorphisms of PECAM-1 encoding amino acid substitutions at positions 98 leucine/valine (L/V), 536 serine/asparagine (S/N), and 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR and VNG).	Arginine	152-160	platelet and endothelial cell adhesion molecule 1	Homo sapiens	35-42
17708746-2	2008	It is a commonly held view that arginase-1 release from injured erythrocytes and hepatocytes leads to arginine breakdown; however, the true relationship between plasma arginase-1 concentration and activity has remained unaddressed.	Arginine	102-110	arginase 1	Homo sapiens	32-42
17993510-6	2008	The functional impairment of the hCNT3(C602R) polymorphism is attributable to the presence of an arginine rather than the loss of a cysteine at position 602, because an engineered hCNT3 protein with a serine residue at this position (hCNT3(C602S)) and hCNT3 have similar kinetic parameters.	Arginine	97-105	solute carrier family 28 member 3	Homo sapiens	33-38
18074159-9	2008	We amplified and sequenced all coding regions of canine ATF2 from a NEWS-affected puppy and identified a T &gt; G transversion that predicts a methionine-to-arginine missense mutation at amino acid position 51.	Arginine	157-165	activating transcription factor 2	Canis lupus familiaris	56-60
18074159-10	2008	Methionine-51 lies within a hydrophobic docking site for mitogen-activated protein kinases that activate ATF-2 so the arginine substitution is likely to interfere with ATF-2 activation.	Arginine	118-126	activating transcription factor 2	Canis lupus familiaris	105-110
18074159-10	2008	Methionine-51 lies within a hydrophobic docking site for mitogen-activated protein kinases that activate ATF-2 so the arginine substitution is likely to interfere with ATF-2 activation.	Arginine	118-126	activating transcription factor 2	Canis lupus familiaris	168-173
17936885-5	2008	in the TST was prevented by pretreatment of mice with L-arginine [a substrate for nitric oxide synthase (NOS)], methylene blue [an inhibitor of NO synthase and sGC] and sildenafil [a phosphodiesterase 5 inhibitor].	Arginine	54-64	nitric oxide synthase 1, neuronal	Mus musculus	82-103
19025114-6	2008	By specific cleavage of the carboxyl terminal arginines from C3a, C5a, bradykinin and thrombin-cleaved osteopontin, it inactivates these active inflammatory mediators.	Arginine	46-55	secreted phosphoprotein 1	Mus musculus	103-114
17845003-2	2008	Both integrins and APN recognize a broad range of peptides containing RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, respectively.	Arginine	75-78	alanyl aminopeptidase, membrane	Homo sapiens	19-22
18984949-2	2008	Conversely, L-arginine (LARG) may have a protective role.	Arginine	12-22	Rho guanine nucleotide exchange factor 12	Homo sapiens	24-28
18978954-7	2008	Upon sequencing the ceramide kinase-like (CERKL) gene, which is mutated in the original RP26 family, we identified a C&gt;A transversion in exon 2 (c.316C&gt;A) that substitutes an arginine residue with a serine (p.R106S) in the conserved nuclear localization signal sequence (KLKRR) of the protein.	Arginine	181-189	ceramide kinase like	Homo sapiens	20-40
18978954-7	2008	Upon sequencing the ceramide kinase-like (CERKL) gene, which is mutated in the original RP26 family, we identified a C&gt;A transversion in exon 2 (c.316C&gt;A) that substitutes an arginine residue with a serine (p.R106S) in the conserved nuclear localization signal sequence (KLKRR) of the protein.	Arginine	181-189	ceramide kinase like	Homo sapiens	42-47
18978954-7	2008	Upon sequencing the ceramide kinase-like (CERKL) gene, which is mutated in the original RP26 family, we identified a C&gt;A transversion in exon 2 (c.316C&gt;A) that substitutes an arginine residue with a serine (p.R106S) in the conserved nuclear localization signal sequence (KLKRR) of the protein.	Arginine	181-189	ceramide kinase like	Homo sapiens	88-92
17726029-1	2007	Previous work showed that prothrombin derivatives cleavable only at Arg-320 (rMZ) or Arg-271 (rP2) are partial, rather than competitive, inhibitors of prothrombin activation by prothrombinase.	Arginine	85-88	RP2 activator of ARL3 GTPase	Rattus norvegicus	94-97
17910065-6	2007	The C139T mutation, predicted to result in the substitution of an arginine by a tryptophan (R47W) in the N-terminal subdomain, affected conserved residues in the PAX9 paired domain.	Arginine	66-74	paired box 9	Homo sapiens	162-166
20869730-3	2010	A homozygous missense mutation, causing a substitution of a molecule of arginine for histidine at the helicase domain of the senataxin protein, was found.	Arginine	72-80	senataxin	Homo sapiens	125-134
18225649-6	2007	For the same reason, this part of the molecule in different nonnative forms of RNase A is less compact and more flexible and is splitted with the highest rate in the segment 31-39 enriched by long cationic residues Lys and Arg.	Arginine	223-226	ribonuclease A family member 1, pancreatic	Homo sapiens	79-86
17917276-0	2007	The effects of glycine and L-arginine on heat stability of ginsenoside Rb1.	Arginine	27-37	RB transcriptional corepressor 1	Homo sapiens	71-74
20735721-6	2010	The heavy chain (HCh) of FVIII was proteolyzed at Arg(740) and Arg(372) more rapidly by FVIIa/TF than by thrombin, consistent with the enhanced activation of FVIII.	Arginine	50-53	coagulation factor VIII	Homo sapiens	25-30
17714089-14	2007	There are two common polymorphic locations of the beta(1)-adrenoceptor, at amino acids 49 (Ser/Gly) and 389 (Arg/Gly).	Arginine	109-112	adrenoceptor beta 1	Homo sapiens	50-70
20735721-6	2010	The heavy chain (HCh) of FVIII was proteolyzed at Arg(740) and Arg(372) more rapidly by FVIIa/TF than by thrombin, consistent with the enhanced activation of FVIII.	Arginine	63-66	coagulation factor VIII	Homo sapiens	25-30
20735721-9	2010	FVIII bound to Glu-Gly-Arg-active-site-modified FVIIa (K(d), ~0.8 nM) with a higher affinity for the HCh than for the LCh (K(d), 5.9 and 18.9 nm).	Arginine	23-26	coagulation factor VIII	Homo sapiens	0-5
21060784-0	2010	A conserved arginine-rich motif within the hypervariable N-domain of Drosophila centromeric histone H3 (CenH3) mediates BubR1 recruitment.	Arginine	12-20	centromere identifier	Drosophila melanogaster	80-102
17626085-5	2007	However, alteration of arginine 119 of TRIM5alphahu or the corresponding arginine 121 of TRIM5alpharh diminished the abilities of the proteins to restrict retroviral infection without affecting trimerization or recognition of the viral capsid.	Arginine	23-31	tripartite motif containing 5	Homo sapiens	39-44
17626085-5	2007	However, alteration of arginine 119 of TRIM5alphahu or the corresponding arginine 121 of TRIM5alpharh diminished the abilities of the proteins to restrict retroviral infection without affecting trimerization or recognition of the viral capsid.	Arginine	73-81	tripartite motif containing 5	Homo sapiens	89-94
17626085-7	2007	Removal of the positively charged side chain from B-box 2 arginines 119/120/121 resulted in diminished proteasome-independent turnover of TRIM5alpha and the related restriction factor TRIMCyp.	Arginine	58-67	tripartite motif containing 5	Homo sapiens	138-148
21060784-0	2010	A conserved arginine-rich motif within the hypervariable N-domain of Drosophila centromeric histone H3 (CenH3) mediates BubR1 recruitment.	Arginine	12-20	centromere identifier	Drosophila melanogaster	104-109
17652459-7	2007	The kinase domain-containing Arg N-terminal half can act through the RhoA inhibitor p190RhoGAP to attenuate stress fiber formation and cell contractility.	Arginine	29-32	Rho GTPase activating protein 35	Homo sapiens	84-94
21060784-0	2010	A conserved arginine-rich motif within the hypervariable N-domain of Drosophila centromeric histone H3 (CenH3) mediates BubR1 recruitment.	Arginine	12-20	Bub1-related kinase	Drosophila melanogaster	120-125
21048924-10	2010	Statistical tests also showed gene-gene interaction of ADH1B Arg+ with ALDH2 Lys+ can bring more risk to ESCC (OR  = 13.46, 95% CI: 2.32-78.07).	Arginine	61-64	aldehyde dehydrogenase 2 family member	Homo sapiens	71-76
17646160-1	2007	Activated protein C (APC) inactivates factor Va (fVa) by proteolytically cleaving fVa heavy chain at Arg(506), Arg(306), and Arg(679).	Arginine	101-104	APC regulator of WNT signaling pathway	Homo sapiens	21-24
17646160-1	2007	Activated protein C (APC) inactivates factor Va (fVa) by proteolytically cleaving fVa heavy chain at Arg(506), Arg(306), and Arg(679).	Arginine	111-114	APC regulator of WNT signaling pathway	Homo sapiens	21-24
17646160-1	2007	Activated protein C (APC) inactivates factor Va (fVa) by proteolytically cleaving fVa heavy chain at Arg(506), Arg(306), and Arg(679).	Arginine	111-114	APC regulator of WNT signaling pathway	Homo sapiens	21-24
17646160-6	2007	The peptide inhibited the APC-dependent cleavage of both Arg(506) and Arg(306) because inhibition was observed with plasma-derived fVa and recombinant R506Q and RR306/679QQ fVa.	Arginine	57-60	APC regulator of WNT signaling pathway	Homo sapiens	26-29
17646160-6	2007	The peptide inhibited the APC-dependent cleavage of both Arg(506) and Arg(306) because inhibition was observed with plasma-derived fVa and recombinant R506Q and RR306/679QQ fVa.	Arginine	70-73	APC regulator of WNT signaling pathway	Homo sapiens	26-29
21058062-9	2010	CHO and Arg decreased glucose-6-phosphatase at 25 d of incubation, whereas NaCl and CHO + Arg increased glucose-6-phosphatase at hatch relative to controls.	Arginine	8-11	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	22-43
17823247-2	2007	The human SR (serine-arginine) protein ASF/SF2 relies on the processive phosphorylation of the serine residues of eight consecutive arginine-serine (RS) dipeptide repeats at the C terminus by SRPK1 before it can be transported into the nucleus.	Arginine	21-29	SRSF protein kinase 1	Homo sapiens	192-197
17823247-2	2007	The human SR (serine-arginine) protein ASF/SF2 relies on the processive phosphorylation of the serine residues of eight consecutive arginine-serine (RS) dipeptide repeats at the C terminus by SRPK1 before it can be transported into the nucleus.	Arginine	132-140	SRSF protein kinase 1	Homo sapiens	192-197
20826463-1	2010	An analysis of SNAP-25 isoform sequences indicates that there is a highly conserved arginine residue (198 in vertebrates, 206 in the genus Drosophila) within the C-terminal region, which is cleaved by botulinum neurotoxin A, with consequent blockade of neuroexocytosis.	Arginine	84-92	Synaptosomal-associated protein 25kDa	Drosophila melanogaster	15-22
17507029-6	2007	Molecular genetic analysis showed a missense mutation predicted to substitute an arginine residue for a serine residue at position 278 in the PSEN1 polypeptide (Arg278Ser).	Arginine	81-89	presenilin 1	Homo sapiens	142-147
20702421-5	2010	We have demonstrated dominant-negative effects mediated by truncated Gal4p and Arg81p proteins in Saccharomyces cerevisiae, interfering with galactose and arginine metabolic pathways, respectively.	Arginine	155-163	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	69-74
17540777-3	2007	The integrin recognizes a tripeptide motif in a small disulfide-bonded loop at the N terminus of the lectin head region of CD23, centered around Arg(172), Lys(173), and Cys(174) (RKC).	Arginine	145-148	Fc epsilon receptor II	Homo sapiens	123-127
20702421-5	2010	We have demonstrated dominant-negative effects mediated by truncated Gal4p and Arg81p proteins in Saccharomyces cerevisiae, interfering with galactose and arginine metabolic pathways, respectively.	Arginine	155-163	Arg81p	Saccharomyces cerevisiae S288C	79-85
17560540-0	2007	Prediction of HIV-1 entry inhibitors neomycin-arginine conjugates interaction with the CD4-gp120 binding site by molecular modeling and multistep docking procedure.	Arginine	46-54	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	91-96
20699397-1	2010	The plant-specific SR45 belongs to the highly conserved family of serine/arginine-rich (SR) proteins, which play key roles in precursor-mRNA splicing and other aspects of RNA metabolism.	Arginine	73-81	arginine/serine-rich 45	Arabidopsis thaliana	19-23
17520355-0	2007	Potent inhibition of HIV-1 replication by backbone cyclic peptides bearing the Rev arginine rich motif.	Arginine	83-91	Rev	Human immunodeficiency virus 1	79-82
20594154-7	2010	The data show that glutamic acid 248, asparagine 267 and, to a lesser extent, arginine 299 are important for the interaction between the MKP3 C-terminal and the N-terminal domains.	Arginine	78-86	dual specificity phosphatase 6	Homo sapiens	137-141
17520355-2	2007	In this work, a series of Backbone Cyclic Peptide (BCP) analogs that bear a conformationally constrained arginine rich motif (ARM) of Rev were tested for in vitro inhibition of HIV-1 replication.	Arginine	105-113	Rev	Human immunodeficiency virus 1	134-137
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Arginine	98-106	immunoglobulin heavy locus	Homo sapiens	17-20
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Arginine	98-106	CDR3	Homo sapiens	21-25
17611644-8	2007	In addition, the IgH-CDR3 of anti-GPI Ab-positive patients was rich in basic-ionized amino acids (arginine, histidine, and lysine) near their central position, suggesting a high affinity.	Arginine	98-106	glucose-6-phosphate isomerase	Homo sapiens	34-37
20728365-0	2010	Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide.	Arginine	38-41	pro-opiomelanocortin-alpha	Mus musculus	153-189
17585213-12	2007	However, carriers of at least one Gly allele of the beta1-adrenergic receptor polymorphism Arg389Gly showed a higher number of adverse events than Arg homozygous (32.4% vs. 18.7%; hazard ratio, 1.87; 95% confidence interval, 1.04-3.35; P = 0.04).	Arginine	91-94	adrenoceptor beta 1	Homo sapiens	52-77
18208322-2	2008	Pedestal formation requires clustering of Tir and subsequent recruitment of cellular tyrosine kinases including Abl, Arg, and Etk as well as signaling molecules Nck, N-WASP, and Arp2/3 complex.	Arginine	117-120	Tir	Escherichia coli	42-45
20728365-0	2010	Replacement of the Lys linker with an Arg linker resulting in improved melanoma uptake and reduced renal uptake of Tc-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide.	Arginine	130-133	pro-opiomelanocortin-alpha	Mus musculus	153-189
18068544-1	2008	We designed the present experiments to investigate the involvement of endogenous nitric oxide synthase (NOS) inhibitors, dimethylarginine dimethylaminohydrolase (DDAH) as a hydrolyzing enzyme of the NOS inhibitors, NOS, arginase which shares l-arginine as a common substrate with NOS, and endothelin-1 (ET-1) in the pulmonary dysfunction after induction of experimental subarachnoid hemorrhage (SAH) in the rabbit.	Arginine	242-252	nitric oxide synthase, brain	Oryctolagus cuniculus	81-102
20840750-7	2010	Moreover, using oligonucleotide-based degenerate PCR, we discovered that mutation of Arg-501 and Lys-503 of mCRY2 within this C-terminal region totally abolishes interaction with PER2.	Arginine	85-88	cryptochrome 2 (photolyase-like)	Mus musculus	108-113
18156033-1	2007	BACKGROUND: New evidence has suggested that people with asthma who are homozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from longacting beta2-agonist therapy.	Arginine	86-94	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
17412895-5	2007	We transduced CX3CL1 (fractalkine), an immunostimulatory chemokine, to the mouse MSCs ex vivo using an adenoviral vector with the Arg-Gly-Asp-4C peptide in the fiber knob.	Arginine	130-133	chemokine (C-X3-C motif) ligand 1	Mus musculus	14-20
20844582-6	2010	Interestingly, substitution of lysine 171 and 196 to arginine of VHL abrogates its inhibitory function on the transcriptional activity of HIFalpha, and tube formation in vitro.	Arginine	53-61	von Hippel-Lindau tumor suppressor	Homo sapiens	65-68
17483093-1	2007	The subunit GluR2 of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subfamily of ionotropic glutamate receptors (GluRs) features a single amino acid at the narrow constriction of the pore loop that is altered from glutamine to arginine by RNA editing.	Arginine	245-253	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	12-17
20641798-8	2004	alpha-MSH (Ac-Ser(1)-Tyr(2)-Ser(3)-Met(4)-Glu(5)-His(6)-Phe(7)-Arg(8)-Trp(9)-Gly(10)-Lys(11)-Pro(12)-Val(13)-NH2), composed of 13 amino acids, is the most potent naturally occurring melanotropic peptide (5).	Arginine	63-66	pro-opiomelanocortin-alpha	Mus musculus	0-9
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	translation elongation factor EF-3	Saccharomyces cerevisiae S288C	47-51
17320923-5	2007	These results indicate a critical role for Arg(59) in the CD4 for conformational changes in gp120 during the sequential process of entry and infection by HIV-1.	Arginine	43-46	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	92-97
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	translation elongation factor EF-3	Saccharomyces cerevisiae S288C	239-243
20626561-2	2010	We now report the effects of the arginine-glycine-aspartic acid (RGD)-containing peptide fragment of OPN and OPN inactivation on the survival of tyrosine hydroxylase (TH) positive neurones in primary rat ventral mesencephalic (VM) cultures and in SN in the rat.	Arginine	33-41	secreted phosphoprotein 1	Rattus norvegicus	101-104
20716763-3	2010	We uncovered a role for the extracellular nutrient arginine in the activation of ERK1/2 in LPS-stimulated macrophages.	Arginine	51-59	mitogen-activated protein kinase 3	Mus musculus	81-87
17764672-4	2007	In order to determine the role of certain conserved, positively charged amino acids in the nucleotide binding domains (NBD-1-4) of hP2X(3) receptors for agonist binding, the lysine-63, -65, -176 and -299 as well as the arginine-281 and -295 residues were substituted by the neutral amino acid alanine.	Arginine	219-227	purinergic receptor P2X 3	Homo sapiens	131-138
17467987-2	2007	The synthesis and in vitro binding of several new arginine-containing C3aR ligands are reported.	Arginine	50-58	complement C3a receptor 1	Homo sapiens	70-74
17560375-4	2007	The ability of IRF-3 to bind these variable sites derives in part from two nonconserved arginines (Arg78 and Arg86) that partake in alternate protein-DNA contacts.	Arginine	88-97	interferon regulatory factor 3	Homo sapiens	15-20
20716763-6	2010	Supplementation of starved mice with arginine promoted the subsequent activation of ERK1/2 and the production of TNF-alpha in response to LPS.	Arginine	37-45	mitogen-activated protein kinase 3	Mus musculus	84-90
18167186-6	2007	C106, CX-1, HT-29, SK01, SW480, SW620 and VACO400 in CHK2 exon 1b were confirmed to have the same nonsense mutation in 11609 A &gt; G. DLD-1 and HCT-15 in CHK2 exon 2 were confirmed to have missense mutation R145W, which was heterozygous C &gt; T missense mutation at nucleotide 433, leading to an Arg &gt; Trp substitution within the FHA domain.	Arginine	298-301	checkpoint kinase 2	Homo sapiens	53-57
20716764-2	2010	Macrophage arginase 1 (Arg1) competes with NO synthases for arginine, a substrate common to both types of enzymes, to inhibit NO production.	Arginine	60-68	arginase 1	Homo sapiens	11-21
20716764-2	2010	Macrophage arginase 1 (Arg1) competes with NO synthases for arginine, a substrate common to both types of enzymes, to inhibit NO production.	Arginine	60-68	arginase 1	Homo sapiens	23-27
17569707-4	2007	One tryptophan and three arginine residues in the sequence were found to be essential both for nucleolin-binding in vivo and HCV replication detected with a HCV subgenomic replicon transfected into Huh7 cells.	Arginine	25-33	nucleolin	Homo sapiens	95-104
20711410-12	2010	Furthermore, ARG1 and ARG2 were enzymatically active and their decreased expression by siRNA resulted in reduced overall arginase activity and l-arginine metabolism.	Arginine	143-153	arginase 1	Homo sapiens	13-17
17341489-0	2007	Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.	Arginine	74-82	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	11-16
17341489-1	2007	Lymphoblast cell lines established from individuals with juvenile Batten disease (JNCL) bearing mutations in CLN3 and yeast strains lacking Btn1p (btn1-Delta), the homolog to CLN3, have decreased intracellular levels of arginine and defective lysosomal/vacuolar transport of arginine.	Arginine	220-228	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	147-151
18032603-6	2007	The P1-P1" position for Egf1.0 has the sequence Arg-Phe, which suggested that its target proteinase is a prophenoloxidase-activating proteinase (PAP).	Arginine	48-51	endogenous retrovirus group K member 18	Homo sapiens	89-99
18032603-6	2007	The P1-P1" position for Egf1.0 has the sequence Arg-Phe, which suggested that its target proteinase is a prophenoloxidase-activating proteinase (PAP).	Arginine	48-51	endogenous retrovirus group K member 18	Homo sapiens	133-143
18165525-2	2007	A genetic single nucleotide polymorphism in the Fc gamma RIIa gene, resulting in arginine (R) or histidine (H) at position 131, affects the binding to the different IgG subclasses and may influence the clinical variations seen in onchocerciasis.	Arginine	81-89	Fc gamma receptor IIa	Homo sapiens	48-61
17341489-1	2007	Lymphoblast cell lines established from individuals with juvenile Batten disease (JNCL) bearing mutations in CLN3 and yeast strains lacking Btn1p (btn1-Delta), the homolog to CLN3, have decreased intracellular levels of arginine and defective lysosomal/vacuolar transport of arginine.	Arginine	275-283	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	147-151
17341489-4	2007	Using the yeast model for the Batten disease, we have determined that although btn1-Delta results in decreased intracellular arginine levels, it does not result from altered arginine uptake, arginine efflux or differences in arginine incorporation into peptides.	Arginine	125-133	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	79-83
20607275-1	2010	Agmatinase catalyzes the hydrolysis of agmatine into putrescine and urea, and agmatine (decarboxylated L: -arginine) plays several roles in mammalian tissues, including neurotransmitter/neuromodulatory actions in the brain.	Arginine	103-115	agmatinase	Homo sapiens	0-10
17341489-5	2007	However, expression of BTN1 is dependent on arginine and Gcn4p, the master regulator of amino acid biosynthesis.	Arginine	44-52	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	23-27
17341489-6	2007	Moreover, deletion of GCN4 (gcn4-Delta), in combination with btn1-Delta, results in a very specific growth requirement for arginine.	Arginine	123-131	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	22-26
17584514-10	2007	Insulin secretion was increased by leucine+glutamine, arginine, alanine or a mixture of amino acids, but their effect was significant only in the presence of forskolin.	Arginine	54-62	insulin	Sus scrofa	0-7
17341489-6	2007	Moreover, deletion of GCN4 (gcn4-Delta), in combination with btn1-Delta, results in a very specific growth requirement for arginine.	Arginine	123-131	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	28-32
20550193-6	2010	The random coil structure of TAT and another CPP, penetratin, suggests that the lack of amphipathic structure is essential for rapid translocation of these Arg-rich CPPs across the lipid membrane without causing permanent damages to the membrane integrity.	Arginine	156-159	tyrosine aminotransferase	Homo sapiens	29-32
17341489-6	2007	Moreover, deletion of GCN4 (gcn4-Delta), in combination with btn1-Delta, results in a very specific growth requirement for arginine.	Arginine	123-131	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	61-65
17341489-7	2007	In addition, increasing the intracellular levels of arginine through overexpression of Can1p, the plasma membrane basic amino acid permease, results in increased cell volume and a severe growth defect specific to basic amino acid availability for btn1-Delta, but not wild-type cells.	Arginine	52-60	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	247-251
17341489-8	2007	Therefore, elevation of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-Delta and perhaps mutation of CLN3 predispose cells to keep arginine levels lower than normal.	Arginine	48-56	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	60-64
17341489-8	2007	Therefore, elevation of intracellular levels of arginine in btn1-Delta cells is detrimental and is suggestive that btn1-Delta and perhaps mutation of CLN3 predispose cells to keep arginine levels lower than normal.	Arginine	48-56	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	115-119
17983687-7	2007	However, the functional groups of arginine are very flexible in the absence of NRP-1 pointing to an induced fit upon binding to the receptor.	Arginine	34-42	neuropilin 1	Homo sapiens	79-84
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Arginine	60-68	Pho80p	Saccharomyces cerevisiae S288C	75-80
20484050-5	2010	APC(S360A) binding to FVa was critically dependent upon the presence of Arg(506) and not Arg(306) and additionally required an active site accessible to substrates.	Arginine	72-75	APC regulator of WNT signaling pathway	Homo sapiens	0-5
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Arginine	60-68	Pho80p	Saccharomyces cerevisiae S288C	180-185
17212359-8	2007	The return of Lys-Ser-Arg of the AT1R to this hybrid led to almost full recovery of Galphai and Galphaq activation.	Arginine	22-25	angiotensin II receptor type 1	Homo sapiens	33-37
20484050-5	2010	APC(S360A) binding to FVa was critically dependent upon the presence of Arg(506) and not Arg(306) and additionally required an active site accessible to substrates.	Arginine	89-92	APC regulator of WNT signaling pathway	Homo sapiens	0-5
18025464-0	2007	Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.	Arginine	51-59	ATP binding cassette subfamily C member 8	Homo sapiens	99-104
17352938-3	2007	Using (11)C-(R)-PK11195 positron emission tomography (PET), we have recently shown in vivo evidence of increased microglial activation in both symptomatic and presymptomatic HD gene carriers and that the degree of microglial activation in the striatum correlates with the severity of striatal dopamine D2 receptor dysfunction measured with (11)C-raclopride PET.	Arginine	13-15	dopamine receptor D2	Homo sapiens	293-313
20484050-7	2010	Our results show that despite exosite interactions near the Arg(506) cleavage site, binding of APC(S360A) to FVa is almost completely dependent on Arg(506) interacting with APC(S360A) to form a nonproductive Michaelis complex.	Arginine	147-150	APC regulator of WNT signaling pathway	Homo sapiens	95-100
20303335-4	2010	Solid-phase synthesis of cRGDyK (Arg-Gly-Asp-(D)Tyr-Lys) peptide and FAM-conjugated peptide were employed for binding to integrin alpha v beta 3.	Arginine	33-36	integrin subunit alpha V	Rattus norvegicus	121-137
17404322-3	2007	Remarkably, this effect was largely restricted to CD4 T cells and correlated with reduced arginine methylation of Vav1, an essential guanine nucleotide exchange factor in T cell stimulation.	Arginine	90-98	vav guanine nucleotide exchange factor 1	Homo sapiens	114-118
17687004-9	2007	The cell-permeant cAMP analogs, L-858051, and VIP inhibited basal p44/p42 MAPK activity by 50, 40, and 40%, respectively.	Arginine	32-34	mitogen activated protein kinase 3	Rattus norvegicus	66-69
17687004-9	2007	The cell-permeant cAMP analogs, L-858051, and VIP inhibited basal p44/p42 MAPK activity by 50, 40, and 40%, respectively.	Arginine	32-34	mitogen activated protein kinase 1	Rattus norvegicus	70-78
20357830-4	2010	This protocol led to the characterization of a human TRIM5alpha variant containing a mutation at arginine 335 as conferring resistance to HIV-1 infection.	Arginine	97-105	tripartite motif containing 5	Homo sapiens	53-63
17937816-12	2007	The alignment between MIF and the arginine repressor demonstrates our algorithm"s ability to detect structural similarities even when spatial rearrangement of structural units has occurred.	Arginine	34-42	macrophage migration inhibitory factor	Homo sapiens	22-25
17582453-1	2007	We previously reported that selected mutations of highly conserved arginine residues within the LLP regions of HIV-1(ME46) gp41 had diverse effects on Env function.	Arginine	67-75	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	151-154
17429808-1	2007	RGDS (Arg-Gly-Asp-Ser) is immobilized on poly(L-lactic acid) (PLLA) with ozone oxidation and the addition of an intermediate reactant, acryl succinimide (ASI) to promote the grafting efficiency.	Arginine	6-9	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	0-4
17267502-7	2007	Furthermore, we have identified an arginine residue, unique to high-risk HPV E6 but outside the canonical core PDZ recognition motif, that plays an important role in the binding of the PDZs of both MAGI-I and SAP97/Dlg, the mutation of which abolishes E6"s ability to degrade the two proteins.	Arginine	35-43	discs large MAGUK scaffold protein 1	Homo sapiens	215-218
17454854-12	2007	Pretreatment with atropine, L-arginine, ondansetron, and (D-Lys3)GHRP-6 inhibited the effects of ghrelin.	Arginine	28-38	ghrelin and obestatin prepropeptide	Rattus norvegicus	97-104
20439497-2	2010	In this study, we report that the residues arginine 119 and threonine 122 in the H2B C-terminal helix are important for transcription and cell growth and play a direct role in controlling H2Bub1 and H3K4 methylation.	Arginine	43-51	H2B clustered histone 13	Homo sapiens	81-86
17928439-9	2007	p190RhoGAP localizes to dendritic spines, and its activity is reduced in arg-/- hippocampus, leading to increased Rho activity.	Arginine	73-76	Rho GTPase activating protein 35	Mus musculus	0-10
17928439-10	2007	Although mutations in p190rhogap enhance dendritic regression resulting from decreased Arg levels, reducing gene dosage of the Rho effector ROCKII can suppress the dendritic regression observed in arg-/- mice.	Arginine	87-90	Rho GTPase activating protein 35	Mus musculus	22-32
20543828-6	2010	Our results indicate that Hv1 most likely forms an internal water wire for selective proton transfer and that interactions between water molecules and S4 arginines may underlie coupling between voltage- and pH-gradient sensing.	Arginine	154-163	hydrogen voltage gated channel 1	Homo sapiens	26-29
17178122-0	2007	Arginine uptake is attenuated, through post-translational regulation of cationic amino acid transporter-1, in hyperlipidemic rats.	Arginine	0-8	solute carrier family 7 member 1	Rattus norvegicus	72-105
17178122-4	2007	Among several transporters that mediate L-arginine uptake, cationic amino acid transporter-1 (CAT-1) acts as a specific arginine transporter for eNOS.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	59-92
17178122-4	2007	Among several transporters that mediate L-arginine uptake, cationic amino acid transporter-1 (CAT-1) acts as a specific arginine transporter for eNOS.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	94-99
17178122-13	2007	In conclusion, aortic arginine uptake is attenuated in hypercholesterolemia, through post-translational modulation of CAT-1 protein, possibly via upregulation of PKC alpha.	Arginine	22-30	solute carrier family 7 member 1	Rattus norvegicus	118-123
17332319-5	2007	Mutational analysis of the complete coding sequence of Par-4 in endometrial cancer cell lines (n = 6) and carcinomas (n = 69) detected a mutation in a single carcinoma, which was localized in exon 3 [Arg (CGA) 189 (TGA) Stop].	Arginine	200-203	pro-apoptotic WT1 regulator	Homo sapiens	55-60
20427285-10	2010	To understand why ZPI has P1 tyrosine, we examined a P1 Arg variant.	Arginine	56-59	serpin family A member 10	Homo sapiens	18-21
17372243-7	2007	The most common CYP1B1 haplotype was Arg(48)-Ala(119)-Val(432)-Asn(453).	Arginine	37-40	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	16-22
17711414-7	2007	The analysis of a T-DNA mutant line lacking AtPRMT11 mRNA revealed reduced levels of proteins with asymmetrically dimethylated arginines, suggesting that AtPRMT11, which is highly similar to mammalian PRMT1, is indeed a type I arginine methyltransferase.	Arginine	127-136	arginine methyltransferase 11	Arabidopsis thaliana	44-52
17711414-7	2007	The analysis of a T-DNA mutant line lacking AtPRMT11 mRNA revealed reduced levels of proteins with asymmetrically dimethylated arginines, suggesting that AtPRMT11, which is highly similar to mammalian PRMT1, is indeed a type I arginine methyltransferase.	Arginine	127-136	arginine methyltransferase 11	Arabidopsis thaliana	154-162
17649707-8	2007	The Arg (CGA) 1933--&gt; stop (TGA) nonsense mutation in MYH9 gene is a causative genetic defect.	Arginine	4-7	T-box transcription factor 1	Homo sapiens	31-34
20463604-4	2010	The experimental data show that activation of alternatively activated macrophages (aaMacs) within type-2 infiltrates by IL-4 or IL-13 can inhibit B16-F1 melanoma cell proliferation through a mechanism that is dependent on arginase-1 depletion of L-arginine within the tumor cell microenvironment.	Arginine	246-256	arginase, liver	Mus musculus	222-232
17649711-1	2007	OBJECTIVE: To investigate the effect of L-arginine on expression of human FVIII gene.	Arginine	40-50	coagulation factor VIII	Homo sapiens	74-79
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	48-53
17956695-6	2007	L-arginine had the same effects on PAC-1, but had no effects on CD62p.	Arginine	0-10	dual specificity phosphatase 2	Homo sapiens	35-40
20520828-1	2010	BACKGROUND: A C-to-A nucleotide transversion (T1405N) in the gene that encodes carbamoyl-phosphate synthetase 1 (CPS1) has been associated with changes in plasma concentrations of L-arginine in term and near term infants but not in adults.	Arginine	180-190	carbamoyl-phosphate synthase 1	Homo sapiens	79-111
17704205-5	2007	We tested the hypothesis that arginase1 activity is modulated by this mechanism, which serves to alter its substrate affinity, allowing competition with NOS for L-arginine.	Arginine	161-171	arginase 1	Rattus norvegicus	30-39
17704205-11	2007	These findings suggest that S-nitrosylated arginase1 can compete with NOS for L-arginine and contribute to endothelial dysfunction in the aging cardiovascular system.	Arginine	78-88	arginase 1	Rattus norvegicus	43-52
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Arginine	0-8	CCAAT enhancer binding protein beta	Homo sapiens	77-86
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Arginine	0-8	CCAAT enhancer binding protein beta	Homo sapiens	163-172
17301242-5	2007	Arginine substitution of the lysine residues within the acetylation motif of C/EBPbeta prevented acetylation and blocked the ability of glucocorticoids to enhance C/EBPbeta-directed transcription and to potentiate C/EBPbeta-dependent preadipocyte differentiation.	Arginine	0-8	CCAAT enhancer binding protein beta	Homo sapiens	163-172
17023580-7	2007	The regulation of cyclin D3 and cdk4 by L-Arg starvation occurs at transcriptional and posttranscriptional levels.	Arginine	40-45	cyclin dependent kinase 4	Homo sapiens	32-36
20520828-1	2010	BACKGROUND: A C-to-A nucleotide transversion (T1405N) in the gene that encodes carbamoyl-phosphate synthetase 1 (CPS1) has been associated with changes in plasma concentrations of L-arginine in term and near term infants but not in adults.	Arginine	180-190	carbamoyl-phosphate synthase 1	Homo sapiens	113-117
17283126-8	2007	Substitution of five lysine residues of RPB8 with arginine residues abolished its ability to be ubiquitinated while preserving its polymerase activity.	Arginine	50-58	RNA polymerase II, I and III subunit H	Homo sapiens	40-44
17483910-6	2007	In the current study we have generated site-specific mutants to study the role of P(-1) subsite residues Arg(36), Asn(39), and Gln(40) of EDN in its catalytic activity.	Arginine	105-108	ribonuclease A family member 2	Homo sapiens	138-141
17483910-7	2007	The individual mutation of Arg(36), Asn (39), and Gln(40) resulted in a reduction in the catalytic activity of EDN on poly(U) and poly(C).	Arginine	27-30	ribonuclease A family member 2	Homo sapiens	111-114
20520828-4	2010	AIM: To examine the putative association between the CPS1 T1405N polymorphism and plasma arginine concentrations in preterm infants.	Arginine	89-97	carbamoyl-phosphate synthase 1	Homo sapiens	53-57
20159986-4	2010	We show that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg(158) and Arg(160) residues.	Arginine	77-80	ribosomal protein S10	Homo sapiens	34-39
17618618-3	2007	One mutation changes a residue in alphaPS2 that is equivalent to the residue in alphaV that contacts the arginine of RGD.	Arginine	105-113	inflated	Drosophila melanogaster	34-42
20159986-4	2010	We show that PRMT5 interacts with RPS10 and catalyzes its methylation at the Arg(158) and Arg(160) residues.	Arginine	90-93	ribosomal protein S10	Homo sapiens	34-39
20159986-5	2010	The methylation of RPS10 at Arg(158) and Arg(160) plays a role in the proper assembly of ribosomes, protein synthesis, and optimal cell proliferation.	Arginine	28-31	ribosomal protein S10	Homo sapiens	19-24
17668007-5	2007	The linker connecting RRM1 and RRM2 contains arginine residues, which provide a binding site for the mRNA export factor TAP, and when TAP binds to this region it displaces RNA bound to RRM2.	Arginine	45-53	ribonucleotide reductase catalytic subunit M1	Homo sapiens	22-26
20102521-2	2010	We demonstrated that RNA editing of GluR2 mRNA at the glutamine/arginine (Q/R) site was decreased in autopsy-obtained spinal motor neurons, but not in cerebellar Purkinje cells, of patients with sporadic ALS.	Arginine	64-72	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	36-41
17110428-3	2007	Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner.	Arginine	209-217	secreted phosphoprotein 1	Rattus norvegicus	38-41
20376790-6	2010	RESULTS: A heterozygous nonsense mutation at codon 564 of the SCNN1B gene from CGA(Arg) to stop codon(TGA) was detector in the proband of family 1.	Arginine	83-86	T-box transcription factor 1	Homo sapiens	102-105
17085448-10	2007	Mutations of the residues of CcpA, which contact Arg-17 of HPr, exhibit differential effects on regulation of catabolic genes.	Arginine	49-52	haptoglobin-related protein	Homo sapiens	59-62
17663752-6	2007	These results indicate that lysines 67 and 313 and arginine 295 play a critical role in forming the proper three-dimensional structure of P2X(4)R for agonist binding and/or channel gating.	Arginine	51-59	purinergic receptor P2X 4	Homo sapiens	138-145
19936946-6	2010	However, the MTHFR 429 Ala/Ala variant (rs1801131) and the TCN2 259 Arg/Arg variant (rs1801198) were associated with CIMP-high status (MTHFR 429 multivariate odds ratio (MV OR) = 7.56; 95% confidence interval (CI), 1.32-43.3; p trend = 0.10; TCN2 259 Arg/Arg variant MV OR = 3.82; 95% CI, 1.02-14.4; p trend = 0.06).	Arginine	68-71	transcobalamin 2	Homo sapiens	59-63
17572409-0	2007	PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus.	Arginine	86-94	proteolysis 6	Arabidopsis thaliana	0-4
16935537-1	2007	Hyperargininemia is a urea cycle disorder caused by mutations in the gene for arginase I (AI) resulting in elevated blood arginine and ammonia levels.	Arginine	5-13	arginase, liver	Mus musculus	78-88
20025859-4	2010	RESULTS: A substitution of C&gt;T in exon 12 was found in both subjects, changing the codon CGA for arginine (aa509) to TGA, a stop codon.	Arginine	100-108	T-box transcription factor 1	Homo sapiens	120-123
17043109-5	2007	Prmt5 and dimethylated H3R8 (histone 3 arginine 8) are localized at the myogenin promoter in differentiating cells.	Arginine	39-47	myogenin	Homo sapiens	72-80
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Arginine	262-265	protein phosphatase 4, catalytic subunit	Mus musculus	194-203
19918264-2	2010	A single nucleotide polymorphism at position 388 of the FGFR4 amino-acid sequence results in the substitution of glycine (Gly) with arginine (Arg) and higher frequency of the ArgArg genotype was previously found in prostate cancer patients.	Arginine	132-140	fibroblast growth factor receptor 4	Homo sapiens	56-61
17599767-1	2007	OBJECTIVE: Previous studies have shown the importance of somatic mutations and arginine residues in the complementarity-determining regions (CDRs) of pathogenic anti-double-stranded DNA (anti-dsDNA) antibodies in human and murine lupus, and in studies of murine antibodies, a role of mutations at position 53 in V(H) CDR2 has been demonstrated.	Arginine	79-87	cerebellar degeneration-related 2	Mus musculus	317-321
17452338-5	2007	The human GnRH receptor has a higher affinity for the cognate GnRH I but a lower affinity for GnRH II and GnRHs from other species possessing substitutions for Arg(8).	Arginine	160-163	gonadotropin releasing hormone receptor	Homo sapiens	10-23
17335496-3	2007	* An arginine-rich intracellular delivery (AID) peptide could rapidly deliver fluorescent proteins or beta-galactosidase enzyme into plant and animal cells in a noncovalent fashion.	Arginine	5-13	galactosidase beta 1	Homo sapiens	102-120
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Arginine	27-30	pro-corazonin	Apis mellifera	35-44
19918264-2	2010	A single nucleotide polymorphism at position 388 of the FGFR4 amino-acid sequence results in the substitution of glycine (Gly) with arginine (Arg) and higher frequency of the ArgArg genotype was previously found in prostate cancer patients.	Arginine	142-145	fibroblast growth factor receptor 4	Homo sapiens	56-61
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Arginine	27-30	pro-corazonin	Apis mellifera	111-120
17140699-3	2007	Very few modifications of [Arg(7)]-corazonin, originally isolated from cockroaches, are known, namely [His(7)]-corazonin which is expressed in certain locusts and the stick insect Carausius morosus, and [Thr(4), His(7)]-corazonin recently described from the honey bee Apis mellifera.	Arginine	27-30	pro-corazonin	Apis mellifera	111-120
20083492-7	2010	In addition, mutating the residue in the PST-01 protease with arginine and serine showed more improvement of the activity.	Arginine	62-70	sulfotransferase family 1A member 1	Homo sapiens	41-44
17140699-6	2007	[Arg(7)]-corazonin is distributed in most major lineages of insects, and is thus the ancient form which was present at the time the phylum Insecta evolved.	Arginine	1-4	pro-corazonin	Apis mellifera	9-18
17346225-2	2007	The substitution of Lys residue by Arg at P1 leads to 2-fold increase in the efficiency of enteropeptidase hydrolysis; the absence of the negatively charged residue at P2 reduces the efficiency of such hydrolysis by two orders of magnitude.	Arginine	35-38	transmembrane serine protease 15	Homo sapiens	91-106
17346225-3	2007	The difference in efficiency of peptide chain hydrolysis after Lys/Arg residues by enteropeptidase compared to trypsin is equal to the difference in hydrolysis by serine proteases of different primary specificity of their specific substrates.	Arginine	67-70	transmembrane serine protease 15	Homo sapiens	83-98
17489562-4	2007	Results obtained with seven lysine and six arginine mutants indicate the importance of K62 that is located in CR1, K182, which is downstream of ACR3, and R155, which immediately follows CR3.	Arginine	43-51	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	110-113
17428245-8	2007	The reduced l-arginine bioavailability to nNOS due to accelerated arginase activity would lead to further impairment of neurogenic NO production, in concert with decreased nNOS protein expression.	Arginine	12-22	nitric oxide synthase, brain	Oryctolagus cuniculus	42-46
17428245-8	2007	The reduced l-arginine bioavailability to nNOS due to accelerated arginase activity would lead to further impairment of neurogenic NO production, in concert with decreased nNOS protein expression.	Arginine	12-22	nitric oxide synthase, brain	Oryctolagus cuniculus	172-176
20047332-7	2010	Biophysical measurements using fluorescence polarization and two-dimensional NMR implicate the intermolecular charge pairing of aspartic acid 777 (VE-Cad) and arginine 609 (par3-PDZ3) as a crucial modulator of complex formation.	Arginine	159-167	par-3 family cell polarity regulator	Homo sapiens	173-177
17158357-2	2007	Low L-arginine levels can result in the uncoupling of nitric oxide synthase (NOS) leading to production of both ROS and RNS.	Arginine	4-14	nitric oxide synthase 1, neuronal	Mus musculus	54-75
17452628-7	2007	This phenotype of the S103P mutation required a cluster of positively charged amino acid residues (Arg or Lys) located close to the mutation site in the Ire1 sequence.	Arginine	99-102	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	153-157
19874476-0	2010	Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency.	Arginine	42-50	cytochrome c oxidase subunit 8A	Homo sapiens	34-38
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	30-38	arginase 1	Homo sapiens	0-10
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	30-38	arginase 1	Homo sapiens	12-16
17032651-3	2006	In the present study, we have used a phage display approach to affinity-optimize the C-terminal linear region of EGF-like growth factors for binding to each ErbB receptor and thereby shown that Arg(45) in EGF impairs binding to both ErbB3 and ErbB4.	Arginine	194-197	erb-b2 receptor tyrosine kinase 3	Homo sapiens	233-238
17032651-3	2006	In the present study, we have used a phage display approach to affinity-optimize the C-terminal linear region of EGF-like growth factors for binding to each ErbB receptor and thereby shown that Arg(45) in EGF impairs binding to both ErbB3 and ErbB4.	Arginine	194-197	erb-b2 receptor tyrosine kinase 4	Homo sapiens	243-248
17176473-1	2006	BACKGROUND: The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich motif that is similar to the one found in Tat.	Arginine	174-182	Rev	Human immunodeficiency virus 1	22-25
17176473-1	2006	BACKGROUND: The HIV-1 Rev protein mediates nuclear export of unspliced and partially spliced viral RNA through interaction with the Rev response element (RRE) by means of an arginine rich motif that is similar to the one found in Tat.	Arginine	174-182	Rev	Human immunodeficiency virus 1	132-135
19950373-6	2010	The p.R95W mutation substitutes a positively charged arginine for a polar tryptophan in the highly conserved RYLAM consensus of the beta 6 sheet of FGF3 that interacts with FGFR2.	Arginine	53-61	fibroblast growth factor 3	Mus musculus	148-152
17210244-9	2006	The first three arginine residues (aa 4-6) of CENP-A appear essential for antibody recognition, as replacing these arginines with glycine residues reduced antibody binding to the expressed CENP-A protein by an average of 93.2% (range 80-100%).	Arginine	16-24	centromere protein A	Homo sapiens	46-52
17287963-4	2007	Cloning and sequencing of the RNR4 locus of the pso3-1 mutant revealed that its intermediate phenotype is attributable to a G --&gt; A transition at nucleotide 352, leading to replacement of glycine by arginine [G118R] in the mutant"s protein.	Arginine	202-210	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	30-34
17287963-4	2007	Cloning and sequencing of the RNR4 locus of the pso3-1 mutant revealed that its intermediate phenotype is attributable to a G --&gt; A transition at nucleotide 352, leading to replacement of glycine by arginine [G118R] in the mutant"s protein.	Arginine	202-210	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	48-52
19950373-6	2010	The p.R95W mutation substitutes a positively charged arginine for a polar tryptophan in the highly conserved RYLAM consensus of the beta 6 sheet of FGF3 that interacts with FGFR2.	Arginine	53-61	fibroblast growth factor receptor 2	Mus musculus	173-178
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Arginine	54-57	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	110-114
16777265-4	2007	26RFa dose-dependently reduced glucose-induced insulin release, inhibited the insulin responses to both arginine and exendin-4 and did not affect glucagon output.	Arginine	104-112	pyroglutamylated RFamide peptide	Rattus norvegicus	0-5
17415970-10	2006	A mutation of C to T was detected by sequencing at the nucleotide 1080 that converts the Arg codon (CGA) to a termination codon (TGA).	Arginine	89-92	T-box transcription factor 1	Homo sapiens	129-132
17197444-3	2007	Using mass spectrometry, we have recently demonstrated in vitro the post-translational incorporation of arginine into the calcium-binding protein calreticulin (CRT).	Arginine	104-112	calreticulin	Rattus norvegicus	146-158
16920835-8	2006	Significantly, analogs of these residues in pol beta (Lys(280), Arg(283), Arg(258), Phe(272), and Tyr(271), respectively) have demonstrated roles in determining enzyme efficiency and fidelity.	Arginine	64-67	DNA polymerase beta	Homo sapiens	44-52
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Arginine	54-57	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	159-163
16920835-8	2006	Significantly, analogs of these residues in pol beta (Lys(280), Arg(283), Arg(258), Phe(272), and Tyr(271), respectively) have demonstrated roles in determining enzyme efficiency and fidelity.	Arginine	74-77	DNA polymerase beta	Homo sapiens	44-52
17197444-3	2007	Using mass spectrometry, we have recently demonstrated in vitro the post-translational incorporation of arginine into the calcium-binding protein calreticulin (CRT).	Arginine	104-112	calreticulin	Rattus norvegicus	160-163
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Arginine	66-69	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	110-114
17315976-1	2007	We synthesized a novel arginine-grafted dendritic block copolymer, R-PAMAM-PEG-PAMAM-R G5 (PPP5-R) for gene delivery systems.	Arginine	23-31	protein phosphatase 5 catalytic subunit	Homo sapiens	91-95
20113510-5	2010	We show that simultaneous mutation of Lys 20, Lys 77, Arg 80, and Arg 149, which interact with DNA in the RFC-PCNA-DNA model, compromises the ability of yeast PCNA to stimulate the DNA-dependent ATPase activity of RFC when the DNA is long enough to extend through the clamp.	Arginine	66-69	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	159-163
19920152-5	2010	In studies employing the recombinant Kunitz domain of APP (APPI), we show that mesotrypsin cleaves selectively at the Arg(15)-Ala(16) reactive site bond, with kinetic constants approaching those of other proteases toward highly specific protein substrates.	Arginine	118-121	serine protease 3	Homo sapiens	79-90
17315976-7	2007	Moreover, in view of the result of various cellular uptake inhibitor treatments during a transfection step, the cellular uptake of PPP5-R polyplex leading to effective transfection is thought to be not dependent on one exclusive pathway and to have the possibility of multiple pathways (caveolae-, clathrin-, and macropinocytosis-mediated pathways), contrary to the caveolae-dependent uptake of the PPP5 polyplex lacking arginine residues.	Arginine	421-429	protein phosphatase 5 catalytic subunit	Homo sapiens	131-135
17130184-5	2007	In this study, cofilin phosphorylation was found to be inhibited by S3-R peptide, which consists of a peptide corresponding to part of the phosphorylation site of cofilin and a membrane-permeable arginine polymer.	Arginine	196-204	cofilin 1	Homo sapiens	15-22
17030535-2	2006	An arginine insertion at codon 352 (insR352) in the presenilin-1 (PSEN1) gene was identified in the proband, but analyses in plasma and CSF suggested a mechanism of neurodegeneration not directly related to amyloid pathophysiology.	Arginine	3-11	presenilin 1	Homo sapiens	52-64
17030535-2	2006	An arginine insertion at codon 352 (insR352) in the presenilin-1 (PSEN1) gene was identified in the proband, but analyses in plasma and CSF suggested a mechanism of neurodegeneration not directly related to amyloid pathophysiology.	Arginine	3-11	presenilin 1	Homo sapiens	66-71
19897492-1	2010	CARM1 is one of nine protein arginine methyltransferases that methylate arginine residues in proteins.	Arginine	29-37	coactivator-associated arginine methyltransferase 1	Mus musculus	0-5
17074833-6	2006	Biochemical and mutational analysis revealed that the DAB2 cell-adhesion Arg-Gly-Asp (RGD) motif (amino acid residues 64-66) and the alphaIIb-integrin-fibrinogen-binding region (amino acid residues 171-464) are important for the DAB2-platelet interactions.	Arginine	73-76	DAB adaptor protein 2	Homo sapiens	54-58
17241125-7	2007	Recombinant bovine AP-B showed preference for Arg-methylcoumarinamide substrate.	Arginine	46-49	arginyl aminopeptidase	Bos taurus	19-23
17241125-9	2007	Bovine AP-B showed similar activities for Arg-(Met)enkephalin (ME) and Lys-ME neuropeptide substrates to generate ME, while rat AP-B preferred Arg-ME.	Arginine	42-45	arginyl aminopeptidase	Bos taurus	7-11
19897710-5	2010	siRNA-mediated knockdown of either GR, TrxR1, or TrxR2 markedly suppressed VEGF-induced NO production (measured by an electrochemical NO sensor) and also blocked eNOS enzyme activity (using the [(3)H]arginine/[(3)H]citrulline assay).	Arginine	200-208	glutathione-disulfide reductase	Homo sapiens	35-37
16971514-11	2006	Our results demonstrate that integrin signaling through Arg activates p190 by promoting its association with p120, resulting in recruitment of p190 to the cell periphery where it inhibits Rho.	Arginine	56-59	contactin associated protein 1	Homo sapiens	70-74
16971514-11	2006	Our results demonstrate that integrin signaling through Arg activates p190 by promoting its association with p120, resulting in recruitment of p190 to the cell periphery where it inhibits Rho.	Arginine	56-59	RAS p21 protein activator 1	Homo sapiens	109-113
20944394-3	2010	Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired.	Arginine	93-101	Vba2p	Saccharomyces cerevisiae S288C	19-23
16971514-11	2006	Our results demonstrate that integrin signaling through Arg activates p190 by promoting its association with p120, resulting in recruitment of p190 to the cell periphery where it inhibits Rho.	Arginine	56-59	contactin associated protein 1	Homo sapiens	143-147
17242372-0	2007	Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase.	Arginine	23-31	coproporphyrinogen oxidase	Homo sapiens	90-116
17242372-0	2007	Role of aspartate 400, arginine 262, and arginine 401 in the catalytic mechanism of human coproporphyrinogen oxidase.	Arginine	41-49	coproporphyrinogen oxidase	Homo sapiens	90-116
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	62-67
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	62-67
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	62-67
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	62-67
16927306-2	2006	The expression of the FGFR-4 Arg(388) variant is correlated with the occurrence of pelvic lymph node metastasis and biochemical (PSA) recurrence in men undergoing radical prostatectomy.	Arginine	29-32	fibroblast growth factor receptor 4	Homo sapiens	22-28
16927306-3	2006	Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression.	Arginine	176-179	fibroblast growth factor receptor 4	Homo sapiens	169-175
16927306-7	2006	Expression of the FGFR-4 Arg(388) variant results in increased expression of Ehm2.	Arginine	25-28	fibroblast growth factor receptor 4	Homo sapiens	18-24
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	36-46	coagulation factor VIII	Homo sapiens	62-67
17649711-7	2007	RESULTS: After 24 h incubation with L-arginine, FVIII: Ag and FVIII: C were increased markedly in the supernatant of HUVEC [FVIII: Ag was (146.08 +/- 4.78) ng/ ml, and FVIII: C (0.752 +/- 0.009) U/ml/10(6) cells x 24 h, while in control supernatant without L-arginine, FVIII: Ag was (34.66 +/- 3.98) ng/ml, and FVIII: C (0.171 +/- 0.006) U/ml/10(6) cell x 24 h, P &lt; 0.01].	Arginine	257-267	coagulation factor VIII	Homo sapiens	48-53
17649711-8	2007	Northern blot analysis indicated that, after adding L-arginine, the transcription of human FVIII mRNA was intensified remarkably in HUVEC transfected with pcDNA6/V5-HisA-BDDhFVIII, but no any transcription in those transfected with pcDNA6/V5-HisA.	Arginine	52-62	coagulation factor VIII	Homo sapiens	91-96
17649711-10	2007	CONCLUSION: L-arginine increases expression of human FVIII gene in HUVEC through enhancing its transcription, particularly, domain A1 and A2 within FVIII gene.	Arginine	12-22	coagulation factor VIII	Homo sapiens	53-58
17649711-10	2007	CONCLUSION: L-arginine increases expression of human FVIII gene in HUVEC through enhancing its transcription, particularly, domain A1 and A2 within FVIII gene.	Arginine	12-22	coagulation factor VIII	Homo sapiens	148-153
19887446-5	2010	Our results show that a positively charged surface on NSF-N, bounded by Arg(67) and Lys(105), and the conserved residues in the central pore of NSF-D1 (Tyr(296) and Gly(298)) are involved in SNAP.SNARE binding but not basal ATP hydrolysis.	Arginine	72-75	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	54-57
17189254-5	2007	SDS-PAGE analysis showed that plasmin cleaved the heavy chain of factor VIII into two terminal products, A1(37-336) and A2 subunits, by limited proteolysis at Lys(36), Arg(336), Arg(372), and Arg(740).	Arginine	168-171	plasminogen	Homo sapiens	30-37
17038548-6	2006	Our results suggest that the Arg-based signal present in Kir6.2 is sterically masked by the SUR1 subunit.	Arginine	29-32	ATP binding cassette subfamily C member 8	Homo sapiens	92-96
17038548-7	2006	By contrast, 14-3-3 proteins functionally antagonized the Arg-based signal present in SUR1.	Arginine	58-61	ATP binding cassette subfamily C member 8	Homo sapiens	86-90
17189254-5	2007	SDS-PAGE analysis showed that plasmin cleaved the heavy chain of factor VIII into two terminal products, A1(37-336) and A2 subunits, by limited proteolysis at Lys(36), Arg(336), Arg(372), and Arg(740).	Arginine	178-181	plasminogen	Homo sapiens	30-37
21516734-5	2010	RESULTS: In patients with CHF, the Gly allele of the Gly389Arg polymorphic locus of the ADRB1 gene in homozygous state was associated with the high individual risk for CHF, the severity of its clinical manifestations and the nature of its course while carriage of the Arg allele of the Gly39Arg polymorphic locus manifested itself as a protective factor.	Arginine	59-62	adrenoceptor beta 1	Homo sapiens	88-93
17189254-5	2007	SDS-PAGE analysis showed that plasmin cleaved the heavy chain of factor VIII into two terminal products, A1(37-336) and A2 subunits, by limited proteolysis at Lys(36), Arg(336), Arg(372), and Arg(740).	Arginine	178-181	plasminogen	Homo sapiens	30-37
17189254-7	2007	Plasmin-catalyzed cleavage at Arg(336) proceeded faster than that at Arg(372), in contrast to proteolysis by factor Xa.	Arginine	30-33	plasminogen	Homo sapiens	0-7
17189254-7	2007	Plasmin-catalyzed cleavage at Arg(336) proceeded faster than that at Arg(372), in contrast to proteolysis by factor Xa.	Arginine	69-72	plasminogen	Homo sapiens	0-7
17189254-10	2007	These results strongly indicated that cleavage at Arg(336) was a central mechanism of plasmin-catalyzed factor VIII inactivation.	Arginine	50-53	plasminogen	Homo sapiens	86-93
17189254-11	2007	Furthermore, the cleavages at Arg(336) and Lys(36) appeared to be selectively regulated by the A2 and A3-C1-C2 domains, respectively, interacting with plasmin.	Arginine	30-33	plasminogen	Homo sapiens	151-158
16765994-0	2006	The importance of arginine mutation for the evolutionary structure and function of phenylalanine hydroxylase gene.	Arginine	18-26	phenylalanine hydroxylase	Homo sapiens	83-108
16765994-4	2006	In many countries, Arginine mutations have the highest frequency among PAH gene mutations in PKU patients.	Arginine	19-27	phenylalanine hydroxylase	Homo sapiens	71-74
16765994-6	2006	In our analyses, we have detected that a majority of mutations causing a change in arginine and other amino acids concentrated in exon 7 comprising the catalytic domain (residues 143-410) of PAH gene.	Arginine	83-91	phenylalanine hydroxylase	Homo sapiens	191-194
21516734-6	2010	During long-term carvedilol therapy, CHF patients with the Arg/Arg genotype of the ADRB1 gene were observed to have a more pronounced decrease in the functional class of heart failure, a significant increase in left ventricular ejection, and a decrease in left ventricular end-systolic and end-diastolic sizes as compared with patients with the Gly/Arg genotype.	Arginine	59-62	adrenoceptor beta 1	Homo sapiens	83-88
21516734-6	2010	During long-term carvedilol therapy, CHF patients with the Arg/Arg genotype of the ADRB1 gene were observed to have a more pronounced decrease in the functional class of heart failure, a significant increase in left ventricular ejection, and a decrease in left ventricular end-systolic and end-diastolic sizes as compared with patients with the Gly/Arg genotype.	Arginine	63-66	adrenoceptor beta 1	Homo sapiens	83-88
17029645-8	2006	DNA sequencing of PMEL17 in Silver and non-Silver horses revealed a missense mutation in exon 11 changing the second amino acid in the cytoplasmic region from arginine to cysteine (Arg618Cys).	Arginine	159-167	premelanosome protein	Equus caballus	18-24
17150966-5	2007	NMR studies showed that the 22 positively charged residues (Lys(18) and Arg(4)) are distributed into three clusters on the surface of hRNase7.	Arginine	72-75	ribonuclease A family member 7	Homo sapiens	134-141
17158873-6	2007	Rat and mouse C5L2 preferentially bound C5a des Arg, whereas rodent C5aR showed much higher affinity for intact C5a.	Arginine	48-51	complement component 5a receptor 2	Mus musculus	14-18
21516734-6	2010	During long-term carvedilol therapy, CHF patients with the Arg/Arg genotype of the ADRB1 gene were observed to have a more pronounced decrease in the functional class of heart failure, a significant increase in left ventricular ejection, and a decrease in left ventricular end-systolic and end-diastolic sizes as compared with patients with the Gly/Arg genotype.	Arginine	63-66	adrenoceptor beta 1	Homo sapiens	83-88
19877579-5	2009	Here we show that Arg to Ala point mutagenesis of the heparin binding motif does not interrupt the folding of endostatin but significantly impairs the interaction between endostatin and nucleolin.	Arginine	18-21	nucleolin	Homo sapiens	186-195
17065601-4	2007	Our data suggest that l-arginine is taken up by Sertoli cells and peritubular cells, principally via system y(+)L (SLC3A2/SLC7A6) and system y(+) (SLC7A1 and SLC7A2), with system B(0+) making a minor contribution.	Arginine	22-32	solute carrier family 7 member 1	Rattus norvegicus	147-153
19877579-6	2009	Double and quadruple mutants showed significantly decreased internalization to endothelial cells and antitumor activities, while the hexad Arg to Ala mutant completely lost its interaction with nucleolin and biological functions.	Arginine	139-142	nucleolin	Homo sapiens	194-203
19877579-7	2009	Taken together, the present study demonstrates that the arginine clusters in the heparin binding motif of endostatin significantly contribute to its interaction with receptor nucleolin and mediate the antiangiogenic and antitumor activities of endostatin.	Arginine	56-64	nucleolin	Homo sapiens	175-184
17084840-6	2007	RESULTS: The FGFR4 Arg(388) allele was detected in 42.5% of the tumors (37% heterozygous Gly/Arg and 5.5% homozygous Arg/Arg).	Arginine	93-96	fibroblast growth factor receptor 4	Homo sapiens	13-18
17084840-9	2007	CONCLUSION: The FGFR4 Arg(388) allele is associated with a shortened survival.	Arginine	22-25	fibroblast growth factor receptor 4	Homo sapiens	16-21
19631198-0	2009	l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide.	Arginine	0-10	glutamate-cysteine ligase catalytic subunit	Homo sapiens	117-142
17291856-2	2007	Inducible nitric oxide synthase (iNOS), ornithine decarboxylase (ODC), and arginase I are involved in the arginine pathway.	Arginine	106-114	ornithine decarboxylase 1	Homo sapiens	40-63
17291856-2	2007	Inducible nitric oxide synthase (iNOS), ornithine decarboxylase (ODC), and arginase I are involved in the arginine pathway.	Arginine	106-114	ornithine decarboxylase 1	Homo sapiens	65-68
19945409-2	2009	In adipocytes, RIP140 can be phosphorylated by protein kinase C epsilon (PKCvarepsilon), followed by arginine methylation, and exported to the cytoplasm.	Arginine	101-109	nuclear receptor interacting protein 1	Mus musculus	15-21
17251515-7	2007	This shows that MMP-20 generates the 23-kDa AMBN starting at Tyr(223), as well as the 17-kDa (Val(1)-Arg(170)) and 15-kDa (Val(1)-Gln(130)) AMBN cleavage products that concentrate in the sheath space during the secretory stage.	Arginine	101-104	matrix metallopeptidase 20	Homo sapiens	16-22
17287563-4	2007	Arginine decarboxylase, arginase and nitric oxide synthase are the key enzymes in L-arginine catabolism, in which polyamines are formed through ADC or arginase-ODC pathway while nitric oxide is formed through the NOS pathway.	Arginine	82-92	ornithine decarboxylase 1	Homo sapiens	160-163
19834685-3	2009	RESULTS: While the kinetics of insulin receptor endocytosis after the administration of arginyl-insulins were similar to those observed using human insulin, a more prolonged concentration of endosomal insulin receptor was observed in response to [Arg(A0)]-HI.	Arginine	247-250	insulin receptor	Homo sapiens	201-217
19834685-4	2009	[Arg(A0)]-HI induced a marked increase in the phosphotyrosine content of endosomal insulin receptor, coinciding with a more sustained endosomal association of growth factor receptor-bound protein 14 (GRB14), and a higher and prolonged activation of mitogen-activated protein kinase pathways.	Arginine	1-4	insulin receptor	Homo sapiens	83-99
19654054-6	2009	These data are consistent with the catalytic role of E186 and R230, and provide, for the first time, experimental support for the essential function of the hitherto not investigated invariant arginine of motif VIII in C5-MTases.	Arginine	192-200	cytochrome c oxidase subunit 8A	Homo sapiens	210-214
17105732-9	2007	An MR mutant in which four lysine residues within sumoylation motifs were mutated into arginine (K89R/K399R/K494R/K953R) failed to be sumoylated, but Ubc9 similarly enhanced transactivation by the mutant MR, indicating that sumoylation activity is dispensable for coactivation capacity of Ubc9.	Arginine	87-95	nuclear receptor subfamily 3 group C member 2	Homo sapiens	3-5
19837749-3	2009	A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles when labeled with radiometals.	Arginine	80-83	pro-opiomelanocortin-alpha	Mus musculus	36-45
17090548-6	2007	The subunits constituting PF4 form a tetrahedron having at its corners a RPRH motif that mimics (in reverse orientation) the Gly-His-Arg-Pro-amide peptides that co-crystallize with fibrin.	Arginine	133-136	platelet factor 4	Homo sapiens	26-29
17041908-9	2007	We hypothesize from these results and previous receptor mutagenesis studies that Arg 6 recruitment of IL5Ralpha occurs through hydrogen bonding as well as charge-charge interactions with Asp 55 in site one of domain 1 of IL5Ralpha, and that this interaction is complemented by additional charged and hydrophobic interactions around the Asp 55 locus.	Arginine	81-84	interleukin 5 receptor subunit alpha	Homo sapiens	102-111
17041908-9	2007	We hypothesize from these results and previous receptor mutagenesis studies that Arg 6 recruitment of IL5Ralpha occurs through hydrogen bonding as well as charge-charge interactions with Asp 55 in site one of domain 1 of IL5Ralpha, and that this interaction is complemented by additional charged and hydrophobic interactions around the Asp 55 locus.	Arginine	81-84	interleukin 5 receptor subunit alpha	Homo sapiens	221-230
19837749-3	2009	A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles when labeled with radiometals.	Arginine	80-83	pro-opiomelanocortin-alpha	Mus musculus	88-97
19837749-3	2009	A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles when labeled with radiometals.	Arginine	113-116	pro-opiomelanocortin-alpha	Mus musculus	36-45
19837749-3	2009	A transition metal rhenium-cyclized alpha-MSH peptide, ReO[Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-targeting profiles when labeled with radiometals.	Arginine	113-116	pro-opiomelanocortin-alpha	Mus musculus	88-97
17116746-4	2007	Arginine 137 was identified in pol beta as an important target for methylation by PRMT1.	Arginine	0-8	DNA polymerase beta	Homo sapiens	31-39
19819988-8	2009	Pretreatment of MG63 cells with Arg-Gly-Asp-Ser, which blocks the cell-extracellular matrix interaction, or transfection with beta(3) integrin-specific siRNA inhibited BMP-4-induced ERK and Smad1/5 phosphorylations.	Arginine	32-35	bone morphogenetic protein 4	Homo sapiens	168-173
17165155-7	2007	RESULTS: All patients carried the same novel MSH2 germline missense mutation (R359S) in exon 7, which determines the substitution of an Arginine, which is a basic amino acid, with a polar Serine residue (R359S).	Arginine	136-144	mutS homolog 2	Homo sapiens	45-49
19673543-1	2009	The human Ewing Sarcoma (EWS) protein belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD) and a C-terminal RNA-binding domain (RBD), which is extensively methylated at arginine residues.	Arginine	236-244	EWS RNA binding protein 1	Homo sapiens	10-23
18543682-2	2007	NO is formed from L-arginine by nitric oxide synthase (NOS).	Arginine	18-28	nitric oxide synthase 1	Homo sapiens	32-53
17140699-10	2007	The [His(4), Gln(7)]-corazonin separates these species from the Namibian Mantophasmatodea which express [Arg(7)]-corazonin and can be used as a distinct character to distinguish these morphologically similar insects.	Arginine	105-108	pro-corazonin	Apis mellifera	21-30
17176473-3	2006	RESULTS: Here, we report the methylation of Rev due to a single arginine dimethylation in the N-terminal portion of its arginine rich motif and the association of Rev with PRMT6 in vivo.	Arginine	64-72	Rev	Human immunodeficiency virus 1	44-47
17176473-3	2006	RESULTS: Here, we report the methylation of Rev due to a single arginine dimethylation in the N-terminal portion of its arginine rich motif and the association of Rev with PRMT6 in vivo.	Arginine	120-128	Rev	Human immunodeficiency virus 1	44-47
17176473-3	2006	RESULTS: Here, we report the methylation of Rev due to a single arginine dimethylation in the N-terminal portion of its arginine rich motif and the association of Rev with PRMT6 in vivo.	Arginine	120-128	Rev	Human immunodeficiency virus 1	163-166
17176473-7	2006	Binding of the Rev arginine rich motif to the RRE was reduced in the presence of wild-type PRMT6, whereas mutant PRMT6 did not exert this negative effect.	Arginine	19-27	Rev	Human immunodeficiency virus 1	15-18
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Arginine	128-136	Rev	Human immunodeficiency virus 1	66-69
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Arginine	128-136	Rev	Human immunodeficiency virus 1	168-171
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Arginine	172-180	Rev	Human immunodeficiency virus 1	66-69
17176473-8	2006	In addition, diminished interactions between viral RNA and mutant Rev proteins were observed, due to the introduction of single arginine to lysine substitutions in the Rev arginine rich motif.	Arginine	172-180	Rev	Human immunodeficiency virus 1	168-171
17018532-3	2006	We investigated the binding reaction between PSD-95 PDZ3 and a peptide corresponding to a native ligand with protein engineering in conjunction with stopped-flow and equilibrium fluorimetry and found that the two conserved residues Arg-318 and His-372 were responsible for the salt and pH dependencies, respectively.	Arginine	232-235	discs large MAGUK scaffold protein 4	Homo sapiens	45-51
17018532-8	2006	Both chloride concentration and pH (during ischemia) vary in the postsynaptic density, where PSD-95 is present, and the physiological buffer conditions may thus modulate the interaction between PSD-95 and its ligands through binding of chloride and protons to the "molecular switches" Arg-318 and His-372, respectively.	Arginine	285-288	discs large MAGUK scaffold protein 4	Homo sapiens	93-99
17018532-8	2006	Both chloride concentration and pH (during ischemia) vary in the postsynaptic density, where PSD-95 is present, and the physiological buffer conditions may thus modulate the interaction between PSD-95 and its ligands through binding of chloride and protons to the "molecular switches" Arg-318 and His-372, respectively.	Arginine	285-288	discs large MAGUK scaffold protein 4	Homo sapiens	194-200
17018057-7	2006	By mutational analysis, we demonstrate that a conserved arginine surrounded by hydrophobic residues is essential for lipid binding, despite very low sequence similarity between PEX1 and valosine-containing protein.	Arginine	56-64	peroxisomal biogenesis factor 1	Homo sapiens	177-181
16971514-0	2006	Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.	Arginine	27-30	Rho GTPase activating protein 35	Homo sapiens	41-51
16971514-0	2006	Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane.	Arginine	27-30	RAS p21 protein activator 1	Homo sapiens	80-90
16971514-6	2006	We show that p190 requires its p120-binding domain to undergo Arg-dependent activation in vivo.	Arginine	62-65	contactin associated protein 1	Homo sapiens	13-17
16971514-6	2006	We show that p190 requires its p120-binding domain to undergo Arg-dependent activation in vivo.	Arginine	62-65	RAS p21 protein activator 1	Homo sapiens	31-35
16730856-1	2006	A novel 26-amino acid peptide possessing the Arg-Phe-NH(2) motif at its C-terminal extremity has been recently characterized and named 26RFamide (26RFa).	Arginine	45-48	pyroglutamylated RFamide peptide	Homo sapiens	135-140
16723138-4	2006	We demonstrated that rats that consumed Arg ( approximately 35 mg/day) in drinking water, during 4 weeks, presented an increase in GH mRNA content (p &lt; 0.01), a decreased peripheral response to insulin, as shown by the reduced blood glucose decay rate (p &lt; 0.05), and a higher insulin plasma concentration (p &lt; 0.01) than control group.	Arginine	40-43	gonadotropin releasing hormone receptor	Rattus norvegicus	131-133
16723138-6	2006	According to the results presented herein we conclude that chronic oral administration of arginine increases GH gene expression and induces insulin resistance.	Arginine	90-98	gonadotropin releasing hormone receptor	Rattus norvegicus	109-111
16804678-1	2006	Crystal structures are reported for the endothelial nitric oxide synthase (eNOS)-arginine-CO ternary complex as well as the neuronal nitric oxide synthase (nNOS) heme domain complexed with L: -arginine and diatomic ligands, CO or NO, in the presence of the native cofactor, tetrahydrobiopterin, or its oxidized analogs, dihydrobiopterin and 4-aminobiopterin.	Arginine	189-201	nitric oxide synthase 1	Homo sapiens	124-154
16804678-1	2006	Crystal structures are reported for the endothelial nitric oxide synthase (eNOS)-arginine-CO ternary complex as well as the neuronal nitric oxide synthase (nNOS) heme domain complexed with L: -arginine and diatomic ligands, CO or NO, in the presence of the native cofactor, tetrahydrobiopterin, or its oxidized analogs, dihydrobiopterin and 4-aminobiopterin.	Arginine	189-201	nitric oxide synthase 1	Homo sapiens	156-160
16310386-1	2006	[Arg(91), Ala(96)] MBP(87-99) is an altered peptide ligand (APL) of myelin basic protein (MBP), shown to actively inhibit experimental autoimmune encephalomyelitis (EAE), which is studied as a model of multiple sclerosis (MS).	Arginine	1-4	myelin basic protein	Homo sapiens	68-88
16310386-1	2006	[Arg(91), Ala(96)] MBP(87-99) is an altered peptide ligand (APL) of myelin basic protein (MBP), shown to actively inhibit experimental autoimmune encephalomyelitis (EAE), which is studied as a model of multiple sclerosis (MS).	Arginine	1-4	myelin basic protein	Homo sapiens	90-93
16760361-8	2006	Based upon the three-dimensional architecture of the human beta1-AR, the distance between Lys324 and the Asp/Glu-Arg-Tyr motif in helix 3 was the shortest among the various amino acids in helix 6.	Arginine	113-116	adrenoceptor beta 1	Homo sapiens	59-67
16198476-1	2006	The FGFR4 codon 388 polymorphism (Arg(388), Arg/Gly(388) or Gly(388)) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles.	Arginine	34-37	fibroblast growth factor receptor 4	Homo sapiens	4-9
16814584-1	2006	Neuronal NOS (nNOS) is a constitutively expressed enzyme that catalyzes the oxidation of L-arginine and water to L-citrulline and the gas nitric oxide (NO).	Arginine	89-99	nitric oxide synthase 1	Homo sapiens	14-18
16847335-0	2006	CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis.	Arginine	85-93	C-X-C motif chemokine receptor 3	Homo sapiens	0-5
16720571-5	2006	The results of this study indicate that (i) the effect of hNPS is mimicked by the fragment hNPS-(1-10); (ii) Phe(2), Arg(3), and Asn(4) are crucial for biological activity; (iii) the sequence Thr(8)-Gly(9)-Met(10) is important for receptor activation, although with non-stringent chemical requirements; and (iv) the sequence Val(6)-Gly(7) acts as a hinge region between the two above-mentioned domains.	Arginine	117-120	neuropeptide S	Homo sapiens	58-62
16764826-3	2006	In this study, we determined that the NO generated from l-arginine by ectopically overexpressed nNOS in HEK293 cells exerted an inhibitory effect against the activity of c-Jun N-terminal kinase (JNK), an important modulator of neuronal cell death and survival signaling pathways.	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	96-100
16756945-2	2006	A missense mutation in the intracellular domain of Tie2 resulting in an arginine to tryptophan substitution causes an inherited form of vascular dysmorphogenesis, venous malformation (VM).	Arginine	72-80	TEK receptor tyrosine kinase	Homo sapiens	51-55
16839343-4	2006	In apparent contrast to these observations, a second LRP-binding region has been identified within A2 domain region Arg(484)-Phe(509) of FVIII heavy chain.	Arginine	116-119	coagulation factor VIII	Homo sapiens	137-142
16681842-1	2006	YopE of Yersinia pseudotuberculosis inactivates three members of the small RhoGTPase family (RhoA, Rac1 and Cdc42) in vitro and mutation of a critical arginine abolishes both in vitro GTPase-activating protein (GAP) activity and cytotoxicity towards HeLa cells, and renders the pathogen avirulent in a mouse model.	Arginine	151-159	Rac family small GTPase 1	Mus musculus	99-103
16703566-3	2006	During activation, most arginine (&gt;95% in 6 h) was metabolized, while under proliferation only half was incorporated into proteins.	Arginine	24-32	inversion, Chr 5, Harwell 6, distal	Mus musculus	42-48
16684551-3	2006	It is found that the replacement of the non-polar amino acid l-leucine at the second position of these heptacyclic peptide toxins by a polar l-arginine reduces their mouse toxicities and inhibitory activities against PP-1 and PP-2A to different extends.	Arginine	141-151	protein phosphatase 1 catalytic subunit gamma	Mus musculus	217-221
16684551-3	2006	It is found that the replacement of the non-polar amino acid l-leucine at the second position of these heptacyclic peptide toxins by a polar l-arginine reduces their mouse toxicities and inhibitory activities against PP-1 and PP-2A to different extends.	Arginine	141-151	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	226-231
16650388-1	2006	The enzyme nitric oxide synthase (NOS) which is necessary for the production of nitric oxide from L-arginine exists in three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	98-108	nitric oxide synthase 1	Homo sapiens	135-147
16650388-1	2006	The enzyme nitric oxide synthase (NOS) which is necessary for the production of nitric oxide from L-arginine exists in three isoforms: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).	Arginine	98-108	nitric oxide synthase 1	Homo sapiens	149-153
16702384-8	2006	The combination genotypes of two polymorphisms revealed the clear effect of the ADH2 Arg allele among those with ALDH2 Glu/Lys in both sexes (P(trend) = 0.007 for men and 0.024 for women).	Arginine	85-88	aldehyde dehydrogenase 2 family member	Homo sapiens	113-118
16527308-8	2006	This arginine-specific interaction appears to be the key determinant for the high affinity binding of PAK peptides.	Arginine	5-13	p21 (RAC1) activated kinase 2	Homo sapiens	102-105
16492668-0	2006	Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.	Arginine	11-19	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	37-78
16492668-6	2006	An hnRNP K variant in which the five quantitatively modified arginine residues had been substituted was not methylated.	Arginine	61-69	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	3-10
16492668-7	2006	Methylation of arginine residues by protein-arginine methyltransferase 1 did not influence the RNA-binding activity, the translation inhibitory function, or the cellular localization of hnRNP K but reduced the interaction of hnRNP K with the tyrosine kinase c-Src.	Arginine	15-23	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	225-232
16600869-0	2006	Arginine methylation regulates DNA polymerase beta.	Arginine	0-8	DNA polymerase beta	Homo sapiens	31-50
16525503-0	2006	An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.	Arginine	3-11	TER94	Drosophila melanogaster	45-48
16525503-0	2006	An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.	Arginine	3-11	TER94	Drosophila melanogaster	49-52
16892378-2	2006	Here, we describe the first experimental evidence for the behavior of an old family of analgesic dipeptides, namely Xaa-Trp(Nps) and Trp(Nps)-Xaa (Xaa=Lys, Arg) derivatives, as potent TRPV1 channel blockers.	Arginine	156-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	184-189
17085797-13	2006	In patients who are homozygous for Arg-16, reduced lung function and increased frequency of exacerbations occur during chronic treatment with short-acting beta2-agonists.	Arginine	35-38	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	155-160
17085797-14	2006	With long-acting beta2-agonists, the overall clinical benefits may be worse for Arg-16 than for the Gly-16 genotype.	Arginine	80-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-22
17012248-10	2006	The "essential arginine" critical for sialic acid recognition in both Siglec-14 and Siglec-5 is present in humans but mutated in almost all great ape alleles.	Arginine	15-23	sialic acid binding Ig like lectin 14	Homo sapiens	70-79
16882747-4	2006	RESULTS: The index case is homozygous for an arginine to cysteine mutation (R102C) of a highly conserved residue within the forkhead, DNA binding domain of TTF-2.	Arginine	45-53	forkhead box E1	Homo sapiens	156-161
17018334-5	2006	Compound H-Arg-15-15C preferentially inhibits TRPV1, showing marginal block of other neuronal receptors.	Arginine	9-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	17-20	defensin, alpha, 4	Mus musculus	135-139
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	17-20	defensin, alpha, 4	Mus musculus	135-139
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	17-20	defensin, alpha, 4	Mus musculus	135-139
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	163-166	defensin, alpha, 4	Mus musculus	135-139
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	163-166	defensin, alpha, 4	Mus musculus	135-139
16822871-7	2006	Because cationic Arg residues are determinants of Crp4 bactericidal peptide activity, we hypothesized that Asp and Glu residues in pro-Crp4(20-43) neutralize Crp4 Arg side chains in pro-Crp4(20-92).	Arginine	163-166	defensin, alpha, 4	Mus musculus	135-139
16867992-4	2006	Indeed, all other Eph receptors, which promiscuously bind many ephrins, have a conserved arginine at the position corresponding to Leu-95 of EphB4.	Arginine	89-97	EPH receptor B4	Homo sapiens	141-146
16829524-7	2006	Comparison of the C2GnT-L structure with that of other GT-A fold glycosyltransferases further suggests that Arg-378 and Lys-401 serve to electrostatically stabilize the nucleoside diphosphate leaving group, a role normally played by metal ion in GT-A structures.	Arginine	108-111	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	18-25
16723138-0	2006	Chronic oral administration of arginine induces GH gene expression and insulin resistance.	Arginine	31-39	gonadotropin releasing hormone receptor	Rattus norvegicus	48-50
16723138-1	2006	Arginine (Arg) presents a potent growth hormone (GH) releasing activity.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	33-47
16723138-1	2006	Arginine (Arg) presents a potent growth hormone (GH) releasing activity.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	49-51
16723138-1	2006	Arginine (Arg) presents a potent growth hormone (GH) releasing activity.	Arginine	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	33-47
16723138-1	2006	Arginine (Arg) presents a potent growth hormone (GH) releasing activity.	Arginine	0-3	gonadotropin releasing hormone receptor	Rattus norvegicus	49-51
16723138-2	2006	In vivo and in vitro studies carried out in our laboratory have demonstrated that acute treatment with Arg also increases GH gene expression.	Arginine	103-106	gonadotropin releasing hormone receptor	Rattus norvegicus	122-124
16723138-3	2006	Taking into account the recognizable diabetogenic role of GH and that Arg increases insulin release, this study aimed at evaluating the effects of oral chronic administration of Arg on GH gene expression, by Northern blotting analysis, and on the insulin sensitivity, by means of the Insulin Tolerance Test (ITT), blood glucose decay rate (kitt) and insulin plasma concentration.	Arginine	178-181	gonadotropin releasing hormone receptor	Rattus norvegicus	185-187
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	197-200	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-144
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-144
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	138-144
19673543-1	2009	The human Ewing Sarcoma (EWS) protein belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD) and a C-terminal RNA-binding domain (RBD), which is extensively methylated at arginine residues.	Arginine	236-244	EWS RNA binding protein 1	Homo sapiens	25-28
19673543-11	2009	As arginine methylation within the RBD of the EWS protein are neither needed for its subcellular localization nor for its protein-protein interaction, a role of EWS protein methylation in RNA-binding and affecting the activation/repression activity or even in the stabilization of the EWS protein seems very likely.	Arginine	3-11	EWS RNA binding protein 1	Homo sapiens	46-49
19806578-6	2009	The nonsense mutation of C to T was detected at the nucleotide 1143, which converted the Arg codon (CGA) to a stop codon(TGA) (R261X) in exon 10.	Arginine	89-92	T-box transcription factor 1	Homo sapiens	121-124
19806579-5	2009	Direct DNA sequence analysis identified a 1080C to T change in exon 9 of the patients, resulting in an Arginine substitution by a stop codon at codon 240 of the PAX6 gene, which was absent in the unaffected individuals in the family and 100 normal controls.	Arginine	103-111	paired box 6	Homo sapiens	161-165
19745150-1	2009	Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo.	Arginine	131-139	nitric oxide synthase 1	Homo sapiens	0-32
19745150-1	2009	Bacterial nitric oxide synthases (bNOS) are present in many Gram-positive species and have been demonstrated to synthesize NO from arginine in vitro and in vivo.	Arginine	131-139	nitric oxide synthase 1	Homo sapiens	34-38
19592491-4	2009	Here we show that SRPK2, a protein kinase specific for the serine/arginine (SR) family of splicing factors, triggers cell cycle progression in neurons and induces apoptosis through regulation of nuclear cyclin D1.	Arginine	66-74	cyclin D1	Homo sapiens	203-212
19582790-4	2009	Three distinct motifs can be discerned in the SRrp37 protein: (1) a serine-arginine (SR) dipeptide enriched domain, (2) a polyserine stretch, and (3) a potential nucleolar localization signal comprising a long array of basic amino acids.	Arginine	75-83	ADP ribosylation factor like GTPase 6 interacting protein 4	Homo sapiens	46-52
19564338-7	2009	Mass spectrometric analysis revealed that ADAM10, but not ADAM9, cleaved PrP between Gly(228) and Arg(229), three residues away from the site of glycosylphosphatidylinositol anchor attachment.	Arginine	98-101	prion protein	Mus musculus	73-76
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	166-169	tyrosine aminotransferase	Homo sapiens	32-36
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	170-173	tyrosine aminotransferase	Homo sapiens	26-30
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	170-173	tyrosine aminotransferase	Homo sapiens	32-36
19601640-3	2009	The trypsinolysis of free TATp, TATp-conjugate, and TATp-Mic revealed that the main initial fragmentation is an endocleavage at the carboxyl terminus resulting in an Arg-Arg (RR) dimer.	Arginine	170-173	tyrosine aminotransferase	Homo sapiens	32-36
19635925-3	2009	In HLA-A2 individuals, this response predominantly uses BV19 chains with Arg-Ser (RS) in the CDR3 loop.	Arginine	73-76	CDR3	Homo sapiens	93-97
16922515-2	2006	We mapped the region of methylation to the C-terminal arginine-glycine-rich residues encoded by FMR1 exon 15.	Arginine	54-62	fragile X mental retardation protein 1	Oryctolagus cuniculus	96-100
16781666-3	2006	In the current study, we demonstrate that arginine-rich intracellular delivery (AID) peptides are able to deliver fluorescent proteins or beta-galactosidase enzyme into animal and plant cells, as well as animal tissue.	Arginine	42-50	galactosidase beta 1	Homo sapiens	138-156
16777221-9	2006	Mutagenesis has also revealed that the outermost arginines of the S4 segment of domain IV influence the activation of CaV3.2, though no specific voltage-sensing amino acid has yet been properly identified.	Arginine	49-58	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	118-124
16569214-1	2006	nNOS (neuronal nitric oxide synthase) is a constitutively expressed enzyme responsible for the production of NO* from L-arginine and O2.	Arginine	118-128	nitric oxide synthase 1	Homo sapiens	0-4
16759229-7	2006	Taken together, the results indicate that mesotrypsin is not a defective protease on polypeptide substrates in general, but exhibits a relatively high specificity for Lys/Arg-Ser/Thr peptide bonds.	Arginine	171-174	serine protease 3	Homo sapiens	42-53
16897183-4	2006	Site-directed mutagenesis showed that Ile(275), Lys(276) and Arg(277) in the C-terminus of PSTD in ST8Sia IV, which is contiguous with the N-terminus of sialylmotif-S, were essential for polysialylation.	Arginine	61-64	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	99-108
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	nuclear receptor subfamily 1 group H member 4	Homo sapiens	168-171
16728691-8	2006	The CC genotype (Arg/Arg) of beta1AR Arg389Gly (odds ratio [OR] 3.4, P=0.030) and the CC genotype (Gln/Gln) of beta2AR Gln27Glu (OR 3.1, P=0.032) were predictive of cTi release.	Arginine	21-24	adrenoceptor beta 1	Homo sapiens	29-36
16939563-4	2006	Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation.	Arginine	0-8	arginase 1	Homo sapiens	58-68
16701564-2	2006	IGFBP-1, which shares an Arg-Gly-Asp (RGD) motif in its C-terminal domain, modulates cell motility by binding to integrin alpha5beta1.	Arginine	25-28	insulin-like growth factor binding protein 1	Mus musculus	0-7
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	clock circadian regulator	Homo sapiens	132-137
16685415-6	2006	These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation.	Arginine	36-39	clock circadian regulator	Homo sapiens	113-118
16569642-3	2006	In addition, IGFBP2 has an Arg-Gly-Asp (RGD) domain, which is a known integrin binding motif.	Arginine	27-30	insulin like growth factor binding protein 2	Homo sapiens	13-19
16433634-6	2006	The most interesting feature of the RCN-3 sequence is the presence of five Arg-Xaa-Xaa-Arg motifs, which represents the target sequence of SPCs.	Arginine	75-78	reticulocalbin 3	Homo sapiens	36-41
16678104-2	2006	The present study demonstrates that c-Abl and Arg (abl-related gene) tyrosine kinases associate with and phosphorylate the proteasome PSMA7 (alpha4) subunit at Tyr-153.	Arginine	46-49	proteasome 20S subunit alpha 7	Homo sapiens	134-139
16717433-2	2006	FPI-F mutants P(1) residues of which, Thr(29), were replaced with Glu, Phe, Gly, Leu, Met, and Arg, were prepared.	Arginine	95-98	fungal protease inhibitor F	Bombyx mori	0-5
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Arginine	43-46	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Arginine	103-106	aldehyde dehydrogenase 2 family member	Homo sapiens	19-24
16672841-1	2006	INTRODUCTION: Several common polymorphisms of the beta2 adrenergic (ADRB2) have been described including a Glycine (Gly) for arginine (Arg) substitution at amino acid 16.	Arginine	125-133	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	50-55
16672841-1	2006	INTRODUCTION: Several common polymorphisms of the beta2 adrenergic (ADRB2) have been described including a Glycine (Gly) for arginine (Arg) substitution at amino acid 16.	Arginine	135-138	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	50-55
16623599-4	2006	In contrast, a high degree of specificity for the basic side chain could be observed because the KIR-DAP12 and FcalphaRI-Fcgamma interactions favored lysine or arginine, respectively.	Arginine	160-168	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	97-100
16610789-9	2006	The Arg(8)-D(2.65) salt bridge might be responsible for analogue-selective binding in OTR and V1aR versus V2R, where the positively charged K(2.65) 100 is present at the equivalent position.	Arginine	4-7	oxytocin receptor	Homo sapiens	86-89
16610789-9	2006	The Arg(8)-D(2.65) salt bridge might be responsible for analogue-selective binding in OTR and V1aR versus V2R, where the positively charged K(2.65) 100 is present at the equivalent position.	Arginine	4-7	arginine vasopressin receptor 1A	Homo sapiens	94-98
16605250-10	2006	A partial displacement of the active-site zinc in the FDH.ADP-ribose binary complex indicates that the disruption of the interaction between Glu-67 and Arg-368 is involved in the displacement of active-site zinc.	Arginine	152-155	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	54-57
16708124-3	2006	These artefactual changes of PA or plasmin activities have been prevented by arginine stabilization of blood samples of myocardial infarction patients treated with plasminogen activators.	Arginine	77-85	plasminogen	Homo sapiens	35-42
16708124-10	2006	Arginine stabilization of blood allows reliable determinations of activities of plasmin and PA in blood of patients under fibrinolytic treatment: substantial plasmin activities occur in patients treated by reteplase.	Arginine	0-8	plasminogen	Homo sapiens	80-87
16708124-10	2006	Arginine stabilization of blood allows reliable determinations of activities of plasmin and PA in blood of patients under fibrinolytic treatment: substantial plasmin activities occur in patients treated by reteplase.	Arginine	0-8	plasminogen	Homo sapiens	158-165
16567525-11	2006	Our results show that nNOS activity contributes to the absence of TDP in mouse islets putatively through depletion of intracellular arginine.	Arginine	132-140	nitric oxide synthase 1, neuronal	Mus musculus	22-26
16539382-4	2006	Analogue 4, c[Nle-Arg-D-Phe-Arg-Trp-Glu]-NH2, was found to be a very potent and selective hMC3R agonist (EC50=1.2 nM, 112% act).	Arginine	17-21	melanocortin 3 receptor	Homo sapiens	90-95
16362416-7	2006	The zebrafish MPR 46 has the arginine residue known to be essential for mannose-6-phosphate binding and other additional characteristic residues of the mannose-6-phosphate ligand-binding pocket.	Arginine	29-37	mannose-6-phosphate receptor (cation dependent)	Danio rerio	14-20
16508003-2	2006	Here, we show a novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover of p21cip1/waf1 mRNA in PC12 cells.	Arginine	35-43	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	165-169
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Arginine	290-298	arginase 1	Homo sapiens	58-68
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Arginine	307-317	arginase 1	Homo sapiens	58-68
16418218-8	2006	Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide.	Arginine	183-186	ral guanine nucleotide dissociation stimulator	Homo sapiens	200-204
16481407-3	2006	Birth weight and length were significantly lower among infants born to continuously smoking women having the aryl hydrocarbon receptor (AhR) wild type genotype (Arg/Arg; 211 g +/- 76 g; 1.2 cm +/- 0.4 cm, p &lt; 0.01 and p &lt; 0.01, respectively), the CYP1A1 variant genotype (m1/m2 + m2/m2; 170 g +/- 64 g, 0.8 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively), or the GSTM1 null genotype (171 g +/- 58 g, 0.6 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively).	Arginine	161-164	aryl hydrocarbon receptor	Homo sapiens	109-134
16481407-3	2006	Birth weight and length were significantly lower among infants born to continuously smoking women having the aryl hydrocarbon receptor (AhR) wild type genotype (Arg/Arg; 211 g +/- 76 g; 1.2 cm +/- 0.4 cm, p &lt; 0.01 and p &lt; 0.01, respectively), the CYP1A1 variant genotype (m1/m2 + m2/m2; 170 g +/- 64 g, 0.8 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively), or the GSTM1 null genotype (171 g +/- 58 g, 0.6 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively).	Arginine	161-164	aryl hydrocarbon receptor	Homo sapiens	136-139
16481407-3	2006	Birth weight and length were significantly lower among infants born to continuously smoking women having the aryl hydrocarbon receptor (AhR) wild type genotype (Arg/Arg; 211 g +/- 76 g; 1.2 cm +/- 0.4 cm, p &lt; 0.01 and p &lt; 0.01, respectively), the CYP1A1 variant genotype (m1/m2 + m2/m2; 170 g +/- 64 g, 0.8 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively), or the GSTM1 null genotype (171 g +/- 58 g, 0.6 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively).	Arginine	165-168	aryl hydrocarbon receptor	Homo sapiens	109-134
16481407-3	2006	Birth weight and length were significantly lower among infants born to continuously smoking women having the aryl hydrocarbon receptor (AhR) wild type genotype (Arg/Arg; 211 g +/- 76 g; 1.2 cm +/- 0.4 cm, p &lt; 0.01 and p &lt; 0.01, respectively), the CYP1A1 variant genotype (m1/m2 + m2/m2; 170 g +/- 64 g, 0.8 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively), or the GSTM1 null genotype (171 g +/- 58 g, 0.6 cm +/- 0.3 cm, p &lt; 0.01 and p &lt; 0.05, respectively).	Arginine	165-168	aryl hydrocarbon receptor	Homo sapiens	136-139
16511941-1	2006	OBJECTIVE: To analyze the frequency of anti-viral citrullinated peptide (anti-VCP) antibodies in sera from patients with rheumatoid arthritis (RA) by an Epstein-Barr virus (EBV)-derived peptide in which arginine is replaced with citrulline.	Arginine	203-211	valosin containing protein	Homo sapiens	78-81
16573685-4	2006	Protein interaction is mediated by the carboxy-terminal Thr-Arg-Leu (TRL) motif of Map and the PSD-95/Disk-large/ZO-1 domain 1 (PDZ1) of EBP50/NHERF1.	Arginine	60-63	discs large MAGUK scaffold protein 4	Homo sapiens	95-101
16573685-4	2006	Protein interaction is mediated by the carboxy-terminal Thr-Arg-Leu (TRL) motif of Map and the PSD-95/Disk-large/ZO-1 domain 1 (PDZ1) of EBP50/NHERF1.	Arginine	60-63	SLC9A3 regulator 1	Homo sapiens	137-142
16573685-4	2006	Protein interaction is mediated by the carboxy-terminal Thr-Arg-Leu (TRL) motif of Map and the PSD-95/Disk-large/ZO-1 domain 1 (PDZ1) of EBP50/NHERF1.	Arginine	60-63	SLC9A3 regulator 1	Homo sapiens	143-149
16256245-2	2006	The cysteine-rich and arginine-rich basic domains represent key components of the HIV-Tat protein for pathogenic effects of the full-length Tat protein and, therefore, could be ideal candidates for the development of a therapeutic AIDS vaccine.	Arginine	22-30	tyrosine aminotransferase	Homo sapiens	86-89
16256245-2	2006	The cysteine-rich and arginine-rich basic domains represent key components of the HIV-Tat protein for pathogenic effects of the full-length Tat protein and, therefore, could be ideal candidates for the development of a therapeutic AIDS vaccine.	Arginine	22-30	tyrosine aminotransferase	Homo sapiens	140-143
16256245-4	2006	Modification of cysteine by introducing either a methyl or t-butyl group in the free sulfhydryl group and replacing the guanidine group with a urea linkage in the side chain of arginine in the cysteine-rich and arginine-rich Tat peptide sequences completely blocked the ability of these peptides to induce HIV replication, chemokine receptor CCR-5 expression, and NF-kappaB activity in monocytes.	Arginine	177-185	tyrosine aminotransferase	Homo sapiens	225-228
16410248-4	2006	With the P(2)-Pro(1) library, FAP preferred Ile, Pro, or Arg at the P(2) residue; however, DPP-4 showed broad reactivity against this library, precluding selectivity.	Arginine	57-60	fibroblast activation protein alpha	Homo sapiens	30-33
16460659-7	2006	The utility of this assay was shown using recombinant rat protein arginine N-methyltransferase 1 (PRMT1, EC 2.1.1.125), which catalyzes the mono- and dimethylation of guanidino nitrogens of arginine residues in select proteins.	Arginine	66-74	protein arginine methyltransferase 1	Rattus norvegicus	98-103
16525050-3	2006	The mutation neutralizes a positively charged arginine in the domain 2 S4 voltage sensor of the Nav1.1 channel alpha subunit.	Arginine	46-54	sodium voltage-gated channel alpha subunit 1	Homo sapiens	96-102
16505150-4	2006	mSlo1 contains several positively charged arginines in S4, but only one (R213) together with residues in S2 (D153, R167) and S3 (D186) are potentially voltage sensing based on the ability of charge-altering mutations to reduce the maximal voltage dependence of P(O).	Arginine	42-51	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	Mus musculus	0-5
16525032-7	2006	DNA sequence analysis revealed a homozygous missense mutation in the hair matrix and cuticle keratin KRTHB5, leading to histidine substitution of a conserved arginine residue (R78H) located in the head domain.	Arginine	158-166	keratin 85	Homo sapiens	101-107
16406488-6	2006	Combination of per se non-effective doses of melatonin (10 and 20 mg/kg) and nitric oxide synthase (NOS) substrate L-arginine (30, 60 mg/kg) showed a significant anticonvulsant activity.	Arginine	115-125	nitric oxide synthase 1, neuronal	Mus musculus	77-98
16424145-5	2006	A solution made of BCAA, L-arginine, and L-glutamine applied before running elevated the BCAA/tryptophan plasma ratio at the end of and after running, and decreased 5-HT release in the lateral hypothalamus and amygdala after running, when compared with the controls.	Arginine	25-35	AT-rich interaction domain 4B	Rattus norvegicus	89-93
16407156-3	2006	Here, we analyzed the function of three residues in the ar/R constriction (Phe-56, His-180, and Arg-195) in rat AQP1.	Arginine	96-99	aquaporin 1	Rattus norvegicus	112-116
16407446-8	2006	For CLV3, processing appears to occur at the absolutely conserved arginine-70 found at the beginning of the CLE domain.	Arginine	66-74	CLAVATA3	Arabidopsis thaliana	4-8
19232413-6	2009	All patients were genotyped for a frequent functional variant at position 131 of the mature FcgammaRIIa, where the arginine (R) allele results in an increased signal transduction upon CRP binding.	Arginine	115-123	Fc gamma receptor IIa	Homo sapiens	92-103
16455328-13	2006	CONCLUSIONS: Nociception in the l-arginine model of acute pancreatitis is partially mediated by the release of CGRP in the dorsal horn of the spinal cord.	Arginine	32-42	calcitonin-related polypeptide alpha	Rattus norvegicus	111-115
19454370-0	2009	Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.	Arginine	53-63	alanyl aminopeptidase, membrane	Homo sapiens	79-96
16430223-0	2006	Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins.	Arginine	59-67	virulence protein	Salmonella enterica	20-24
16430223-0	2006	Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins.	Arginine	59-67	virulence protein	Salmonella enterica	124-128
16430223-10	2006	We identified arginine-177 as the modification site for C/SpvB with the actin homologue protein Act88F from Drosophila.	Arginine	14-22	virulence protein	Salmonella enterica	56-62
19454370-0	2009	Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.	Arginine	53-63	alanyl aminopeptidase, membrane	Homo sapiens	97-101
19454370-1	2009	A series of L-arginine derivatives were designed, synthesized and assayed for their activities against amino-peptidase N (APN)/CD13 and metalloproteinase-2 (MMP-2).	Arginine	12-22	alanyl aminopeptidase, membrane	Homo sapiens	103-120
19454370-1	2009	A series of L-arginine derivatives were designed, synthesized and assayed for their activities against amino-peptidase N (APN)/CD13 and metalloproteinase-2 (MMP-2).	Arginine	12-22	alanyl aminopeptidase, membrane	Homo sapiens	122-125
16401070-9	2006	The effect was much greater than that reported earlier for another charge isomer of MBP, C8, in which six arginines were deiminated to citrulline, resulting in a reduction of net positive charge of 6.	Arginine	106-115	myelin basic protein	Homo sapiens	84-87
16719801-4	2006	The NA active site is highly polar and formed mostly by arginine, aspartate and glutamate residues.	Arginine	56-64	neuraminidase 1	Homo sapiens	4-6
19454370-1	2009	A series of L-arginine derivatives were designed, synthesized and assayed for their activities against amino-peptidase N (APN)/CD13 and metalloproteinase-2 (MMP-2).	Arginine	12-22	alanyl aminopeptidase, membrane	Homo sapiens	127-131
19454370-1	2009	A series of L-arginine derivatives were designed, synthesized and assayed for their activities against amino-peptidase N (APN)/CD13 and metalloproteinase-2 (MMP-2).	Arginine	12-22	matrix metallopeptidase 2	Homo sapiens	157-162
19251784-2	2009	Peroxynitrite production may result from simultaneous synthesis of nitric oxide (NO) and superoxide by inducible NO-synthase (iNOS) at low L-arginine concentrations.	Arginine	139-149	nitric oxide synthase, inducible	Cavia porcellus	103-124
17135210-5	2006	Surprisingly, Tra, Tra2 and 9G8 are much stronger splicing activators than other SR protein family members and their activation potential is significantly higher than expected from their serine/arginine content.	Arginine	194-202	x16 splicing factor	Drosophila melanogaster	28-31
16091583-6	2006	TRPV1(VAR) is predicted to encode a truncated form of TRPV1 consisting of the NH2-terminal 248 residues of TRPV1 (all within the NH2-terminal intracellular domain) followed by five nonconsensus amino acids (Arg-Glu-Ala-Met-Trp) and a stop codon.	Arginine	207-210	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
16091583-6	2006	TRPV1(VAR) is predicted to encode a truncated form of TRPV1 consisting of the NH2-terminal 248 residues of TRPV1 (all within the NH2-terminal intracellular domain) followed by five nonconsensus amino acids (Arg-Glu-Ala-Met-Trp) and a stop codon.	Arginine	207-210	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
16091583-6	2006	TRPV1(VAR) is predicted to encode a truncated form of TRPV1 consisting of the NH2-terminal 248 residues of TRPV1 (all within the NH2-terminal intracellular domain) followed by five nonconsensus amino acids (Arg-Glu-Ala-Met-Trp) and a stop codon.	Arginine	207-210	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
19251784-2	2009	Peroxynitrite production may result from simultaneous synthesis of nitric oxide (NO) and superoxide by inducible NO-synthase (iNOS) at low L-arginine concentrations.	Arginine	139-149	nitric oxide synthase, inducible	Cavia porcellus	126-130
16777756-7	2006	edrophonium injection (stimulating at the second neuron level) resulted in a smaller increase in PP concentrations in the type 1 diabetic patients as compared with the healthy subjects, whereas direct PP-cell stimulation by arginine infusion resulted in similar increments in PP concentrations in the two groups.	Arginine	224-232	pancreatic polypeptide	Homo sapiens	201-203
19251784-3	2009	L-arginine availability to iNOS is regulated by its cellular uptake, which can be inhibited by eosinophil-derived polycations and by arginase, which competes with iNOS for the common substrate.	Arginine	0-10	nitric oxide synthase, inducible	Cavia porcellus	27-31
16777756-7	2006	edrophonium injection (stimulating at the second neuron level) resulted in a smaller increase in PP concentrations in the type 1 diabetic patients as compared with the healthy subjects, whereas direct PP-cell stimulation by arginine infusion resulted in similar increments in PP concentrations in the two groups.	Arginine	224-232	pancreatic polypeptide	Homo sapiens	201-203
19251784-3	2009	L-arginine availability to iNOS is regulated by its cellular uptake, which can be inhibited by eosinophil-derived polycations and by arginase, which competes with iNOS for the common substrate.	Arginine	0-10	nitric oxide synthase, inducible	Cavia porcellus	163-167
19362556-6	2009	However, the overall homology of GnRH-I precursor polypeptide (including a 23 amino acid signal peptide, the decapeptide hormone and Gly-Lys-Arg cleavage site followed by 55 amino acid GnRH-associated peptide sequences) between starling and chicken was only 58%.	Arginine	141-144	LOW QUALITY PROTEIN: progonadoliberin-1	Sturnus vulgaris	33-39
16289034-4	2005	The exchange of a conserved leucine residue with arginine in the CRIC domain increases the binding affinity of CNK1 to the AT2 receptor.	Arginine	49-57	angiotensin II receptor, type 2	Mus musculus	123-135
16263090-5	2005	Characterization of the FGF3 binding domain of rpS2 showed that both the Arg-Gly-rich N-terminal region and a short carboxyl-terminal sequence of rpS2 are necessary for FGF3 binding.	Arginine	73-76	fibroblast growth factor 3	Homo sapiens	169-173
16343269-2	2006	An amino acid (AA) substitution for arginine at the 452 AA position of the ALAS2 protein is the most frequent mutation, which has been found in approximately one-quarter of patients with XLSA.	Arginine	36-44	5'-aminolevulinate synthase 2	Homo sapiens	75-80
16319129-7	2006	Recombinant protein arginine methyl transferase 1 (PRMT1) methylates Fmrp on the same arginines in vitro as in cells.	Arginine	86-95	Arginine methyltransferase 1	Drosophila melanogaster	20-49
19289494-3	2009	Using the Cre/lox-conditional system, we show that the loss of PRMT1 in mouse embryonic fibroblasts (MEFs) leads to the loss of arginine methylation of substrates harboring a glycine-arginine rich motif, including Sam68 and MRE11.	Arginine	128-136	lysyl oxidase	Mus musculus	14-17
16354780-11	2006	Our previous results showed that both lysine and arginine mediate escapin"s bacteriostatic effects, but only lysine mediates its bactericidal effects.	Arginine	49-57	L-amino-acid oxidase	Aplysia californica	66-73
16354780-12	2006	Given that escapin"s antimicrobial effects require concentrations of lysine and/or arginine &gt;1 mmol l(-1), our data lead us to conclude that lysine in opaline is the primary natural substrate for escapin in ink.	Arginine	83-91	L-amino-acid oxidase	Aplysia californica	11-18
16354780-14	2006	Whether lysine and/or arginine are substrates for escapin"s antipredatory functions remains to be determined.	Arginine	22-30	L-amino-acid oxidase	Aplysia californica	50-57
16167335-8	2005	TNF-alpha-induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor (10(-8) M), while LPS- or Bay K 8644-induced decrease in cell number was significantly prevented by caspase-3 inhibitor or N omega-nitro-L-arginine methylester (NAME) (10(-5) M), an inhibitor of nitric oxide (NO) synthase.	Arginine	262-271	caspase 3	Rattus norvegicus	104-113
16167335-8	2005	TNF-alpha-induced decrease in the number of wild-type cells was significantly prevented by culture with caspase-3 inhibitor (10(-8) M), while LPS- or Bay K 8644-induced decrease in cell number was significantly prevented by caspase-3 inhibitor or N omega-nitro-L-arginine methylester (NAME) (10(-5) M), an inhibitor of nitric oxide (NO) synthase.	Arginine	262-271	caspase 3	Rattus norvegicus	224-233
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	158-161	dynein axonemal heavy chain 8	Homo sapiens	103-109
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	171-174	dynein axonemal heavy chain 8	Homo sapiens	19-25
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	171-174	dynein axonemal heavy chain 8	Homo sapiens	103-109
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	171-174	dynein axonemal heavy chain 8	Homo sapiens	103-109
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	27-30	valosin containing protein	Homo sapiens	91-94
17219957-0	2006	Influence of L-arginine on the expression of eNOS and COX2 in experimental pulmonary thromboembolism.	Arginine	13-23	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	54-58
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	27-30	dynein axonemal heavy chain 8	Homo sapiens	113-119
19570335-6	2009	With the results of the genotyping analyses, PECAM-1 gene Leu125Val, Asn563Ser and Gly670Arg polymorphisms showed strong linkage disequilibrium, and the Val-Ser-Arg haplotype was associated with a significantly increased risk of AMI as compared with the controls (OR=1.489, 95%CI: 1.118-1.984, P=0.006).	Arginine	89-92	platelet and endothelial cell adhesion molecule 1	Homo sapiens	45-52
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	27-30	valosin containing protein	Homo sapiens	132-135
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	40-43	valosin containing protein	Homo sapiens	91-94
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	40-43	dynein axonemal heavy chain 8	Homo sapiens	113-119
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	40-43	valosin containing protein	Homo sapiens	132-135
17219957-1	2006	The influence of L-arginine on endothelial nitric oxide synthase (eNOS) and cyclooxygenase 2 (COX2) was observed in experimental pulmonary thromboembolism and the action mechanism on pulmonary thromboembolism was explored.	Arginine	17-27	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	76-92
17219957-1	2006	The influence of L-arginine on endothelial nitric oxide synthase (eNOS) and cyclooxygenase 2 (COX2) was observed in experimental pulmonary thromboembolism and the action mechanism on pulmonary thromboembolism was explored.	Arginine	17-27	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	94-98
17219957-12	2006	In conclusion, L-arginine can educe the role of pulmonary tissue protection through up-regulating the expression of intra-pulmonary NOS and down -regulating COX2 in pulmonary thromboembolism.	Arginine	15-25	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	157-161
19570335-7	2009	CONCLUSION: PECAM-1 gene Leu125Val polymorphism and its Val-Ser-Arg haplotype are associated with AMI, Val allele is an important genetic susceptibility gene for AMI.	Arginine	64-67	platelet and endothelial cell adhesion molecule 1	Homo sapiens	12-19
16236255-3	2005	We show that the elimination of this methylation in the SmD3 protein, by mutating the modified arginines to leucines, does not interfere with the assembly and the nuclear transport of the transiently expressed SmD3 variant.	Arginine	95-104	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	56-60
19339032-4	2009	Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro.	Arginine	43-51	Rev	Human immunodeficiency virus 1	23-26
16362795-5	2005	WRN codon 1367 produces variant proteins with an Arg or cysteine (Cys).	Arginine	49-52	WRN RecQ like helicase	Homo sapiens	0-3
16362795-10	2005	The allele frequencies of the WRN polymorphism were: Cys=0.73 and Arg=0.27.	Arginine	66-69	WRN RecQ like helicase	Homo sapiens	30-33
16362795-11	2005	The crude genotypic frequencies in gastric cancer patients were similar to those of the controls, but in the WRN codon 1367 polymorphisms the mean age tended to be higher in the Arg/Arg genotypes.	Arginine	178-181	WRN RecQ like helicase	Homo sapiens	109-112
16362795-11	2005	The crude genotypic frequencies in gastric cancer patients were similar to those of the controls, but in the WRN codon 1367 polymorphisms the mean age tended to be higher in the Arg/Arg genotypes.	Arginine	182-185	WRN RecQ like helicase	Homo sapiens	109-112
16583127-5	2006	The mutation causes arginine to be replaced by glycine in codon 65 (R65G) in the juxtamembrane region of EDA.	Arginine	20-28	ectodysplasin A	Homo sapiens	105-108
19339032-4	2009	Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro.	Arginine	43-51	Rev	Human immunodeficiency virus 1	39-42
19339032-4	2009	Nap1 was found to bind Rev through the Rev arginine-rich domain and altered the oligomerization state of Rev in vitro.	Arginine	43-51	Rev	Human immunodeficiency virus 1	39-42
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	heme oxygenase (decycling) 2, pseudogene 1	Rattus norvegicus	199-215
16690412-2	2005	The DQA1*0107 allele, found in three unrelated Caucasian participants, contains a novel polymorphism at codon 79 of exon 2 (CGC--&gt;TGC), which results in an amino acid change from an arginine to a cysteine.	Arginine	185-193	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	4-8
16690412-4	2005	The DQA1*0602 allele, found in one Caucasian participant, contains a novel polymorphism at codon 139 of exon 3 (AGC--&gt;CGC), which results in an amino acid change from a serine to an arginine.	Arginine	185-193	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	4-8
16175316-6	2005	The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (&gt;or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population).	Arginine	227-230	sulfotransferase family 1A member 1	Homo sapiens	4-11
16175316-6	2005	The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (&gt;or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population).	Arginine	291-294	sulfotransferase family 1A member 1	Homo sapiens	4-11
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	glutathione synthetase	Rattus norvegicus	217-239
16175316-6	2005	The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (&gt;or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population).	Arginine	291-294	sulfotransferase family 1A member 1	Homo sapiens	4-11
16175316-7	2005	Similarly, the risk associated with a long duration (&gt;or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype.	Arginine	223-226	sulfotransferase family 1A member 1	Homo sapiens	121-128
16175316-7	2005	Similarly, the risk associated with a long duration (&gt;or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype.	Arginine	277-280	sulfotransferase family 1A member 1	Homo sapiens	121-128
19188198-4	2009	This results in a change of the initiation codon in ATPase 6 to threonine and a concurrent change from a highly conserved hydrophobic amino acid, tryptophan, at position 55 of ATPase 8 to a highly basic arginine.	Arginine	203-211	mitochondrially encoded ATP synthase 6	Homo sapiens	52-60
16175316-7	2005	Similarly, the risk associated with a long duration (&gt;or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype.	Arginine	277-280	sulfotransferase family 1A member 1	Homo sapiens	121-128
16237103-4	2005	Arginine-specific gingipain (Rgp) caused a marked production of HGF into the supernatant, the induction of HGF expression on the cell surface, and the up-regulation of HGF mRNA expression in a dose-dependent and an enzymatic activity-dependent manner.	Arginine	0-8	hepatocyte growth factor	Homo sapiens	64-67
19265705-7	2009	However, an additional arginine side chain (Arg37) was observed flanking the re-side of the PLP ring in the ABDC active site.	Arginine	23-31	pyridoxal phosphatase	Homo sapiens	92-95
16396320-2	2005	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P &gt; 0.05 by chi2-test).	Arginine	49-52	proteasome 20S subunit beta 9	Homo sapiens	77-81
19636199-4	2009	The molecular analysis of CYP17A1 revealed a novel homozygous missense mutation resulting in the substitution of arginine to lysine at the amino acid position 21 (p.R21L).	Arginine	113-121	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	26-33
19178193-6	2009	Post-translational modifications of MBP which reduced its net positive charge, i.e., phosphorylation or arginine deimination, increased the degree of repulsion of Fyn-SH3 from the membrane surface, an effect further modulated by the lipid charge.	Arginine	104-112	myelin basic protein	Homo sapiens	36-39
15849232-1	2005	In cultured endothelial cells, 70-95% of extracellular l-arginine uptake has been attributed to the cationic amino acid transporter-1 protein (CAT-1).	Arginine	55-65	solute carrier family 7 member 1	Rattus norvegicus	100-141
15849232-1	2005	In cultured endothelial cells, 70-95% of extracellular l-arginine uptake has been attributed to the cationic amino acid transporter-1 protein (CAT-1).	Arginine	55-65	solute carrier family 7 member 1	Rattus norvegicus	143-148
15849232-2	2005	We tested the hypothesis that extracellular l-arginine entry into endothelial cells via CAT-1 plays a crucial role in endothelial nitric oxide (NO) production during in vivo conditions.	Arginine	44-54	solute carrier family 7 member 1	Rattus norvegicus	88-93
15849232-3	2005	Using l-lysine, the preferred amino acid transported by CAT-1, we competitively inhibited extracellular l-arginine transport into endothelial cells during conditions of NaCl hyperosmolarity, low oxygen, and flow increase.	Arginine	104-114	solute carrier family 7 member 1	Rattus norvegicus	56-61
15849232-7	2005	These results suggest that l-arginine from the extracellular space is accumulated by CAT-1.	Arginine	27-37	solute carrier family 7 member 1	Rattus norvegicus	85-90
15849232-8	2005	When CAT-1-mediated transport of extracellular l-arginine into endothelial cells was suppressed, the endothelial cell NO response to a wide range of physiological stimuli was strongly depressed.	Arginine	47-57	solute carrier family 7 member 1	Rattus norvegicus	5-10
19154146-1	2009	Nitric oxide (NO), which is produced from L-arginine by the nitric oxide synthase (NOS) family of enzymes, is an important second-messenger molecule that regulates several physiological functions.	Arginine	42-52	nitric oxide synthase 1	Homo sapiens	60-81
16141802-3	2005	The His allele (SULT1A1*2) has been shown to encode a protein with much lower catalytic activity than the protein encoded by the Arg allele (SULT1A1*1).	Arginine	129-132	sulfotransferase family 1A member 1	Homo sapiens	16-23
16141802-3	2005	The His allele (SULT1A1*2) has been shown to encode a protein with much lower catalytic activity than the protein encoded by the Arg allele (SULT1A1*1).	Arginine	129-132	sulfotransferase family 1A member 1	Homo sapiens	141-148
19226119-7	2009	The pH profiles of SDH(WT), SDH(R55M), and SDH(R55Q) show that the arginine substitution also alters the behavior of the Mo-heme IET equilibrium (K(eq)) and rate constants (k(et)) of both variants with respect to the SDH(WT) enzyme.	Arginine	67-75	serine dehydratase	Homo sapiens	19-22
16044463-1	2005	The multifunctional Ewing Sarcoma (EWS) protein, a member of a large family of RNA-binding proteins, is extensively asymmetrically dimethylated at arginine residues within RGG consensus sequences.	Arginine	147-155	EWS RNA binding protein 1	Homo sapiens	35-38
19226119-7	2009	The pH profiles of SDH(WT), SDH(R55M), and SDH(R55Q) show that the arginine substitution also alters the behavior of the Mo-heme IET equilibrium (K(eq)) and rate constants (k(et)) of both variants with respect to the SDH(WT) enzyme.	Arginine	67-75	serine dehydratase	Homo sapiens	28-31
19226119-7	2009	The pH profiles of SDH(WT), SDH(R55M), and SDH(R55Q) show that the arginine substitution also alters the behavior of the Mo-heme IET equilibrium (K(eq)) and rate constants (k(et)) of both variants with respect to the SDH(WT) enzyme.	Arginine	67-75	serine dehydratase	Homo sapiens	28-31
16079143-3	2005	Inhibition studies in both the presence and absence of PZ revealed that Arg-143, Lys-147, and Arg-154 of the autolysis loop and Lys-96, Lys-169, and Lys-236 of the heparin binding exosite are required for recognition of ZPI, with Arg-143 being essential for the interaction.	Arginine	72-75	serpin family A member 10	Homo sapiens	220-223
19226119-7	2009	The pH profiles of SDH(WT), SDH(R55M), and SDH(R55Q) show that the arginine substitution also alters the behavior of the Mo-heme IET equilibrium (K(eq)) and rate constants (k(et)) of both variants with respect to the SDH(WT) enzyme.	Arginine	67-75	serine dehydratase	Homo sapiens	28-31
19236007-4	2009	Here we demonstrate that a single amino acid mutation at the position of glycine 131 to lysine or arginine in wild-type rhTRAIL significantly improved the affinity of rhTRAIL toward its death receptors, with the highest affinity increase observed for the DR4 receptor.	Arginine	98-106	TNF receptor superfamily member 10a	Homo sapiens	255-258
16153125-7	2005	To encourage cell adhesion, PUs were surface-modified with radio frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS).	Arginine	114-117	ral guanine nucleotide dissociation stimulator	Homo sapiens	131-135
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Arginine	83-86	carboxypeptidase B2	Homo sapiens	50-54
16098926-0	2005	WRN gene 1367 Arg allele protects against development of type 2 diabetes mellitus.	Arginine	14-17	WRN RecQ like helicase	Homo sapiens	0-3
16098926-4	2005	When polymorphism of the WRN gene was analyzed in 272 randomly recruited type 2 diabetic subjects (age 64.5+/-11.1), we found those with Cys/Arg to be older than those with Cys/Cys (p=0.021) and that the age at diagnosis of diabetes was greater in Cys/Arg than in Cys/Cys subjects (p=0.011).	Arginine	141-144	WRN RecQ like helicase	Homo sapiens	25-28
16098926-4	2005	When polymorphism of the WRN gene was analyzed in 272 randomly recruited type 2 diabetic subjects (age 64.5+/-11.1), we found those with Cys/Arg to be older than those with Cys/Cys (p=0.021) and that the age at diagnosis of diabetes was greater in Cys/Arg than in Cys/Cys subjects (p=0.011).	Arginine	252-255	WRN RecQ like helicase	Homo sapiens	25-28
16098926-7	2005	These results suggest that the 1367 Arg allele of the WRN gene protects against the development of type 2 diabetes mellitus in Japanese.	Arginine	36-39	WRN RecQ like helicase	Homo sapiens	54-57
19074424-7	2009	When other positively charged surface residues of TAFI (Lys-133, Lys-211, Lys-212, Arg-220, Lys-240, or Arg-275) were mutated to alanine, the catalytic efficiencies for TAFI activation with TM decreased by 1.7-2.7-fold.	Arginine	104-107	carboxypeptidase B2	Homo sapiens	50-54
19218452-1	2009	Force-distance measurements between supported lipid bilayers mimicking the cytoplasmic surface of myelin at various surface coverages of myelin basic protein (MBP) indicate that maximum adhesion and minimum cytoplasmic spacing occur when each negative lipid in the membrane can bind to a positive arginine or lysine group on MBP.	Arginine	297-305	myelin basic protein	Homo sapiens	137-157
15937148-7	2005	Pre-exposure of SG neurons to the ORL1 receptor blocker, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101), significantly decreased the Noc-mediated Ca(2+) current inhibition.	Arginine	66-69	opioid related nociceptin receptor 1	Rattus norvegicus	34-38
19218452-1	2009	Force-distance measurements between supported lipid bilayers mimicking the cytoplasmic surface of myelin at various surface coverages of myelin basic protein (MBP) indicate that maximum adhesion and minimum cytoplasmic spacing occur when each negative lipid in the membrane can bind to a positive arginine or lysine group on MBP.	Arginine	297-305	myelin basic protein	Homo sapiens	159-162
15945061-3	2005	This suggests that methylphenidate and N-methyl-4-methyl-methylphenidate, but not N-benzylmethylphenidate, interact with the guanidine groups of arginine residues in the DAT of rat striatum.	Arginine	145-153	solute carrier family 6 member 3	Rattus norvegicus	170-173
19038856-10	2009	These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival.	Arginine	163-171	solute carrier family 7 member 2	Homo sapiens	58-64
16114892-1	2005	This work describes the synthesis and activity of a novel backbone cyclic (BC) peptide library based on the sequence of the HIV-1 Rev arginine-rich motif (ARM).	Arginine	134-142	Rev	Human immunodeficiency virus 1	130-133
16408119-0	2006	Arginine uptake is attenuated through modulation of cationic amino-acid transporter-1, in uremic rats.	Arginine	0-8	solute carrier family 7 member 1	Rattus norvegicus	52-85
16408119-4	2006	Among several transporters that mediate L-arginine uptake, cationic amino-acid transporter-1 (CAT-1) acts as the specific arginine transporter for eNOS.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	59-92
16408119-4	2006	Among several transporters that mediate L-arginine uptake, cationic amino-acid transporter-1 (CAT-1) acts as the specific arginine transporter for eNOS.	Arginine	40-50	solute carrier family 7 member 1	Rattus norvegicus	94-99
19129454-4	2009	Adjoined to this, the carboxy-terminal half of P64 (residues 279 to 455) contained 14 copies of a highly basic, tandemly repeated motif rich in arginine and serine, having an 11- to 13-amino-acid consensus sequence, SPSQRRSTS(V/K)(A/S)RR, yielding a predicted isoelectric point of 12.2 for this protein.	Arginine	144-152	interleukin 2 receptor subunit gamma	Homo sapiens	47-50
17065069-3	2006	We homozygously identified the CGA insertion after A666 of the MOCS1 gene which produces arginine insertion at codon 222 of MOCS1A.	Arginine	89-97	molybdenum cofactor synthesis 1	Homo sapiens	63-68
16339852-6	2006	Results of domain-swapping experiments between plant-specific RSp29 and SCL26, which is a homolog of human SC35, showed the importance of RNA recognition motif 1 and the Arg/Ser-rich (RS) domain for the enhancement of splicing efficiencies.	Arginine	170-173	serine and arginine rich splicing factor 2	Homo sapiens	107-111
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Arginine	138-141	gonadotropin releasing hormone 1	Homo sapiens	115-119
16083426-5	2005	Although the consensus for AurA is reminiscent of that of PKA (protein kinase A), it significantly differs from the latter for a much more stringent dependence on the hydrophobic residue at n+1 and for its tolerance of residues other than Arg at position n-3.	Arginine	239-242	aurora kinase A	Homo sapiens	27-31
19129181-6	2009	Using recombinant factor Va variants FVa-R506Q/R679Q and FVa-R306Q/R679Q, PF4 was shown to impair APC proteolysis of FVa at position Arg(306) by 3-fold both in the presence and absence of protein S. These data suggest that PF4 contributes to the poorly understood APC resistance phenotype associated with activated platelets.	Arginine	133-136	platelet factor 4	Homo sapiens	74-77
18987357-2	2009	Using chimeric human-rat alphaIIbbeta3 molecules, we found that this difference in Arg-Gly-Asp-Ser (RGDS) sensitivity was the result of amino acid substitutions at residues 157, 159, and 162 in the W3:4-1 loop and an Asp-His replacement at residue 232 in the W4:4-1 loop of the alphaIIb beta propeller.	Arginine	83-86	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	100-104
16042866-9	2005	CONCLUSIONS: Nitric oxide can induce the tyrosine phosphorylation of BK(Ca) alpha subunit, which influences the vascular hyporesponsiveness in hemorrhagic shock rats or induced by L-arginine in vitro.	Arginine	180-190	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	69-81
17236649-1	2006	It is widely recognized that nitric oxide (NO) in mammalian tissues is produced from L-arginine via catalysis by NO synthase (NOS) isoforms such as neuronal NOS (nNOS) and endothelial NOS (eNOS) that are constitutively expressed mainly in the central and peripheral nervous system and vascular endothelial cells, respectively.	Arginine	85-95	nitric oxide synthase 1	Homo sapiens	113-124
17236649-1	2006	It is widely recognized that nitric oxide (NO) in mammalian tissues is produced from L-arginine via catalysis by NO synthase (NOS) isoforms such as neuronal NOS (nNOS) and endothelial NOS (eNOS) that are constitutively expressed mainly in the central and peripheral nervous system and vascular endothelial cells, respectively.	Arginine	85-95	nitric oxide synthase 1	Homo sapiens	148-160
17236649-1	2006	It is widely recognized that nitric oxide (NO) in mammalian tissues is produced from L-arginine via catalysis by NO synthase (NOS) isoforms such as neuronal NOS (nNOS) and endothelial NOS (eNOS) that are constitutively expressed mainly in the central and peripheral nervous system and vascular endothelial cells, respectively.	Arginine	85-95	nitric oxide synthase 1	Homo sapiens	162-166
15890773-9	2005	In addition, substitution at positions corresponding to Arg155 in human MCH receptor 2 and rat somatostatin receptor 2 also markedly abolished their ligand-induced signaling capacities, indicating that this Arg is a recognition determinant in several G protein-coupled receptors.	Arginine	56-59	somatostatin receptor 2	Rattus norvegicus	95-118
19101556-2	2009	We examined and confirmed the arginine methylation of hnRNP K protein by PRMT1, not CARM1, via their direct binding.	Arginine	30-38	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	54-61
16061726-0	2005	CD28 costimulatory signal induces protein arginine methylation in T cells.	Arginine	42-50	CD28 molecule	Homo sapiens	0-4
16061726-3	2005	Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1.	Arginine	51-59	CD28 molecule	Homo sapiens	19-23
16061726-3	2005	Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1.	Arginine	51-59	vav guanine nucleotide exchange factor 1	Homo sapiens	146-150
16429495-18	2005	We have made the homologous mutation in the mouse AChE and BuChE genes and showed that the Arg to Cys mutations resulted in identical alterations in the cellular phenotype for the various members of the alpha/beta-hydrolase fold family proteins.	Arginine	91-94	acetylcholinesterase	Mus musculus	50-54
16429495-18	2005	We have made the homologous mutation in the mouse AChE and BuChE genes and showed that the Arg to Cys mutations resulted in identical alterations in the cellular phenotype for the various members of the alpha/beta-hydrolase fold family proteins.	Arginine	91-94	abhydrolase domain containing 15	Mus musculus	203-223
16216872-0	2005	Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein.	Arginine	39-42	valosin containing protein	Homo sapiens	88-91
16216872-0	2005	Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein.	Arginine	39-42	valosin containing protein	Homo sapiens	92-118
19116148-2	2009	DNA sequencing revealed that these cells expressed an equilibrative nucleoside transporter 1 (ENT1) with a single missense mutation resulting in glycine to arginine replacement (G24R).	Arginine	156-164	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	54-92
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	158-161	dynein axonemal heavy chain 8	Homo sapiens	19-25
16216872-9	2005	Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer.	Arginine	158-161	dynein axonemal heavy chain 8	Homo sapiens	103-109
16012731-8	2005	In conclusion, a Thr to Arg single nucleotide polymorphism in the extracellular domain of DR4 could not be associated with the development and progression of gastric cancer.	Arginine	24-27	TNF receptor superfamily member 10a	Homo sapiens	90-93
16153439-11	2005	L-arginine supplementation resulted in increases of perfusion, density of capillary endothelial, and level of endothelial nitric oxide synthase in the ischemic region.	Arginine	0-10	nitric oxide synthase 3	Sus scrofa	110-143
19116148-2	2009	DNA sequencing revealed that these cells expressed an equilibrative nucleoside transporter 1 (ENT1) with a single missense mutation resulting in glycine to arginine replacement (G24R).	Arginine	156-164	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	94-98
16251196-2	2005	A previous study on the yeast homolog to CLN3, designated Btn1p, revealed a potential role for CLN3 in the transport of arginine into the yeast vacuole, the equivalent organelle to the mammalian lysosome.	Arginine	120-128	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	58-63
19139398-6	2009	Two lines of evidence suggest that DauA and DauB are required for D-to-L racemization of arginine.	Arginine	89-97	NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB	Pseudomonas aeruginosa PAO1	44-48
16234340-7	2005	Several arginine analog inhibitors of nNOS were revealed to be differentially reversible over increasing substrate concentrations.	Arginine	8-16	nitric oxide synthase 1	Homo sapiens	38-42
16039561-2	2005	Here we report that mutation of pairs of arginine gating charges to glutamine induces cation permeation through a gating pore in domain II of the Na(V)1.2a channel.	Arginine	41-49	neuron navigator 1	Homo sapiens	146-152
19139398-7	2009	First, growth complementation of an L-arginine auxotroph by D-arginine was abolished by a lesion at dauA or dauB.	Arginine	36-46	NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB	Pseudomonas aeruginosa PAO1	108-112
16013863-4	2005	For RNAse A, quantitative reduction of the disulfide bonds lead to the exposure of an additional arginine residue and two different conformations of the reduced protein were observed by ESI-MS that could be distinguished according to their charge-state distribution.	Arginine	97-105	ribonuclease A family member 1, pancreatic	Homo sapiens	4-11
16267770-2	2005	METHODS: Fc gamma RIIa mutation at amino acid position 131 (arginine or histidine) was detected by polymerase chain reaction, and in vitro cultures for parasites were used to assess the invasion rate.	Arginine	60-68	Fc gamma receptor IIa	Homo sapiens	9-22
19139398-9	2009	This hypothesis was further supported by activity measurements of the purified enzymes: DauA catalyzes oxidative deamination of D-arginine into 2-ketoarginine and ammonia, and DauB is able to use 2-ketoarginine and ammonia as substrates and convert them into L-arginine in the presence of NADPH or NADH.	Arginine	259-269	NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB	Pseudomonas aeruginosa PAO1	176-180
19139398-10	2009	Thus, we propose that DauA and DauB are coupled catabolic and anabolic dehydrogenases to perform D-to-L racemization of arginine, which serves as prerequisite of D-arginine utilization through L-arginine catabolic pathways.	Arginine	120-128	NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB	Pseudomonas aeruginosa PAO1	31-35
16038412-2	2005	One such mutation at a highly conserved arginine residue was shown to cause major conformational defects and intracellular aggregation of alphaA- and alphaB-crystallins and HspB8.	Arginine	40-48	heat shock protein beta-8	Cricetulus griseus	173-178
19139398-10	2009	Thus, we propose that DauA and DauB are coupled catabolic and anabolic dehydrogenases to perform D-to-L racemization of arginine, which serves as prerequisite of D-arginine utilization through L-arginine catabolic pathways.	Arginine	193-203	NAD(P)H-dependent anabolic L-arginine dehydrogenase DauB	Pseudomonas aeruginosa PAO1	31-35
18930476-7	2009	Genetic studies revealed a G --&gt; A transition at nucleotide position 80 in exon 1 of the Cav-3 gene (c.80G&gt;A), generating a Arg --&gt; Gln change at codon 27 (p.R27Q) of the amino acid chain in heterozygous state, while no mutation was found in unaffected members.	Arginine	130-133	caveolin 3	Homo sapiens	92-97
15988032-3	2005	Here we show that the TLS protein forms complexes with RNA polymerase II (Pol II) and the serine-arginine family of splicing factors in vivo.	Arginine	97-105	fused in sarcoma	Mus musculus	22-25
15922518-3	2005	IL-4 alters macrophage arginine metabolism by inducing arginase I expression and inhibiting nitric oxide production.	Arginine	23-31	arginase, liver	Mus musculus	55-65
16157597-0	2005	A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs.	Arginine	19-27	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	31-36
16157597-4	2005	We found that a single conserved arginine (Arg-298) in the V3 region of gp120 governs HIV-1 binding to syndecans.	Arginine	33-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-77
16157597-4	2005	We found that a single conserved arginine (Arg-298) in the V3 region of gp120 governs HIV-1 binding to syndecans.	Arginine	43-46	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-77
19144837-3	2009	The GAERS Ca(v)3.2 mutation (gcm) produces an arginine to proline (R1584P) substitution in exon 24 of Cacna1h, encoding a portion of the III-IV linker region in Ca(v)3.2. gcm segregates codominantly with the number of seizures and time in seizure activity in progeny of an F1 intercross.	Arginine	46-54	calcium voltage-gated channel subunit alpha1 H	Rattus norvegicus	102-109
16211557-3	2005	We report here the first patient with a homozygous substitution of a highly conserved threonine residue by an arginine (c.80C>G, Thr27Arg) localized in the N-terminal BRCT domain of MCPH1.	Arginine	110-118	microcephalin 1	Homo sapiens	182-187
16293771-10	2005	OPN significantly reduced the STZ-induced NO levels in the islets through an Arg-Gly-Asp (RGD)-dependent reduction of inducible NO synthase (iNOS) mRNA levels.	Arginine	77-80	secreted phosphoprotein 1	Rattus norvegicus	0-3
15896703-4	2005	As a result, the phosphatase activity of both HBP isoforms is negligible, but we found that it could be recovered by restoration of the arginine by site directed mutagenesis.	Arginine	136-144	heme binding protein 1	Homo sapiens	46-49
15973048-3	2005	Here we describe mutant Put4 permeases, in which up to nine lysine residues in the cytoplasmic N-terminal domain have been replaced by arginine.	Arginine	135-143	proline permease PUT4	Saccharomyces cerevisiae S288C	24-28
19319842-5	2009	Accordingly, endothelial dysfunction can be prevented by (1) enhancement of BH4 synthesis through supplementation of its precursor (sepiapterin) via the salvage pathway; (2) transfer of the gene for GTP cyclohydrolase-I (the first and key regulatory enzyme for de novo synthesis of BH4); or (3) dietary supplementation of L-arginine (which stimulates GTP cyclohydrolase-I expression and inhibits hexosamine production).	Arginine	322-332	GTP cyclohydrolase 1	Homo sapiens	199-219
15973048-4	2005	The steady-state protein level of the mutant permease Put4-20p (Lys9, Lys34, Lys35, Lys60, Lys68, Lys71, Lys93, Lys105, Lys107 --&gt; Arg) was largely higher compared to that of the wild-type Put4p, indicating that the N-terminal lysines can undergo ubiquitination and the subsequent degradation steps.	Arginine	134-137	proline permease PUT4	Saccharomyces cerevisiae S288C	54-58
15811879-1	2005	Arginase 1, an enzyme induced by Th2 cytokines, is a hallmark of alternatively activated macrophages and is responsible for the hydrolysis of L-arginine into ornithine, the building block for the production of polyamines.	Arginine	142-152	arginase 1	Homo sapiens	0-10
16176874-7	2005	Analysis of the CYP17 gene by polymerase chain reaction amplification and direct sequencing demonstrated a novel homozygous mutation of codon 440 from CGC (Arg) to TGC (Cys) in both patients.	Arginine	156-159	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-21
19152634-6	2009	The peptides generally had a similar conformation but those with the extra Arg residue displayed a significantly increased affinity for the RXFP3.	Arginine	75-78	relaxin family peptide receptor 3	Homo sapiens	140-145
16120648-4	2005	An arginine substitution of K418 abolishes SUMO-1 conjugation and although it does not interfere with ADAR1 proper localization, it stimulates the ability of the enzyme to edit RNA both in vivo and in vitro.	Arginine	3-11	small ubiquitin like modifier 1	Homo sapiens	43-49
15893521-9	2005	Taking these data together, we suggest that SST-induced hSSTR1 up-regulation is critically dependent upon a specific Lys-Ser-Arg sequence in the C-tail of the receptor, with Ser360 being essential.	Arginine	125-128	somatostatin receptor 1	Homo sapiens	56-62
19628295-4	2009	Unexpectedly, resting as well as stimulated inflammatory macrophages constitutively exhibited high levels of phosphorylated eIF2alpha, which was not further increased upon l-arginine starvation.	Arginine	172-182	eukaryotic translation initiation factor 2A	Mus musculus	124-133
15878348-3	2005	Comparison of sequences of the Smu1 gene from wild-type and mutant cells revealed that the mutant phenotype is caused by a G-to-A transition that yields a gly-to-arg substitution at position 489 in hamster Smu1.	Arginine	162-165	SMU1 DNA replication regulator and spliceosomal factor	Homo sapiens	31-35
19109200-2	2009	In this study, we describe modification of the CXC chemokine stromal cell-derived factor 1alpha/CXCL12 by peptidylarginine deiminase (PAD) that converts arginine residues into citrulline (Cit), thereby reducing the number of positive charges.	Arginine	114-122	C-X-C motif chemokine ligand 12	Homo sapiens	96-102
15826818-9	2005	IL-4 appears to be an important Th2 cytokine involved in the induction of the L-arginine/iNOS pathway in eosinophils.	Arginine	78-88	interleukin 4	Rattus norvegicus	0-4
15701644-5	2005	Arginine-stimulated insulin secretion, pancreatic insulin mRNA and peptide levels, beta cell mass, islet architecture, and GLUT2 and PDX-1 immunoreactivity in RIP-G Tg pancreas were not significantly different from those of nontransgenic littermates.	Arginine	0-8	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	123-128
16447780-1	2005	AMPA receptor-mediated neuronal death is initiated by exaggerated Ca2+ influx through AMPA receptor channels, and the Ca2+ permeability of the AMPA receptor ion channel depends strongly upon the presence or absence in its composition of an edited GluR2 subunit whose glutamine (Q) residue is substituted by arginine (R) at the Q/R site due to RNA editing.	Arginine	307-315	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	247-252
16396320-2	2005	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P &gt; 0.05 by chi2-test).	Arginine	45-48	proteasome 20S subunit beta 9	Homo sapiens	77-81
16396320-2	2005	It was shown that interrelation of genotypes Arg/Arg, Arg/His and His/His in LMP2 gene polymorphism is 52, 40.5 and 7.5 % correspondingly (in control group 53.8, 38.7, 7.5 %; P &gt; 0.05 by chi2-test).	Arginine	49-52	proteasome 20S subunit beta 9	Homo sapiens	77-81
19109200-3	2009	The three NH(2)-terminal arginines of CXCL12, Arg(8), Arg(12), and Arg(20), were citrullinated upon incubation with PAD.	Arginine	25-34	C-X-C motif chemokine ligand 12	Homo sapiens	38-44
19109200-3	2009	The three NH(2)-terminal arginines of CXCL12, Arg(8), Arg(12), and Arg(20), were citrullinated upon incubation with PAD.	Arginine	46-49	C-X-C motif chemokine ligand 12	Homo sapiens	38-44
19109200-5	2009	Three CXCL12 isoforms were synthesized for biologic characterization: CXCL12-1Cit, CXCL12-3Cit, and CXCL12-5Cit, in which Arg(8), Arg(8)/Arg(12)/Arg(20), or all five arginines were citrullinated, respectively.	Arginine	122-125	C-X-C motif chemokine ligand 12	Homo sapiens	6-12
19348906-8	2009	Subsequently replacing ARG8(m) with mutated versions of cytochrome b results in arginine auxotrophy.	Arginine	80-88	cytochrome b	Saccharomyces cerevisiae S288C	56-68
16129413-2	2005	D.Asn-Pro-(N-Me)Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH(2) (dNPA) displays a very high affinity (0.027nM) for NPFF(2) receptors transfected in CHO cells, and a very high selectivity with a discrimination ratio greater than 100 versus NPFF(1) receptors.	Arginine	44-47	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	109-113
16129413-2	2005	D.Asn-Pro-(N-Me)Ala-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH(2) (dNPA) displays a very high affinity (0.027nM) for NPFF(2) receptors transfected in CHO cells, and a very high selectivity with a discrimination ratio greater than 100 versus NPFF(1) receptors.	Arginine	44-47	pro-FMRFamide-related neuropeptide FF	Cricetulus griseus	233-237
19160662-3	2009	Protein domains including PH, FYVE, ENTH, PHOX, PHD fingers, and lysine-/arginine-rich patches can bind to specific phosphoinositide isomers, which, in turn, can induce changes in the subcellular localization, posttranslational modification, protein interaction partners, or activity of the protein containing such a domain.	Arginine	73-81	clathrin interactor 1	Homo sapiens	36-40
16087677-11	2005	Cleavage of the syndecan-1 fusion protein by thrombin occurred only at a control cleavage site (Arg downward arrowGly) introduced into the linker region connecting the ectodomain with the enhanced yellow fluorescent protein.	Arginine	96-99	syndecan 1	Homo sapiens	16-26
20066896-1	2009	The genotype analysis of the Gly and Arg allele at codon 388 of fibroblast growth factor receptor-4 (FGFR4) gene was evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population.	Arginine	37-40	fibroblast growth factor receptor 4	Homo sapiens	64-99
20066896-1	2009	The genotype analysis of the Gly and Arg allele at codon 388 of fibroblast growth factor receptor-4 (FGFR4) gene was evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a hospital-based Malaysian population.	Arginine	37-40	fibroblast growth factor receptor 4	Homo sapiens	101-106
18487077-1	2009	The aim of this study was to investigate the predisposition of the FGFR4 Gly/Arg polymorphism for development of head and neck squamous cell carcinoma (HNSCC) and, furthermore, to examine if the FGFR4 Arg(388) allele can be associated with resistance to chemo- and radiotherapy.	Arginine	77-80	fibroblast growth factor receptor 4	Homo sapiens	67-72
18487077-1	2009	The aim of this study was to investigate the predisposition of the FGFR4 Gly/Arg polymorphism for development of head and neck squamous cell carcinoma (HNSCC) and, furthermore, to examine if the FGFR4 Arg(388) allele can be associated with resistance to chemo- and radiotherapy.	Arginine	201-204	fibroblast growth factor receptor 4	Homo sapiens	195-200
19221590-7	2009	Administering the NO Synthase-inhibitory arginine analog N-Nitro-L-Arginine-Methyl-Ester (L-NAME) but not its inactive enantiomer D-NAME increased once again sensitivity to infection to levels expected for relish mutants.	Arginine	41-49	Nitric oxide synthase	Drosophila melanogaster	18-29
18806759-4	2008	In this study, we identify the splicing factor SC35, a member of the Ser-Rich Arg (SR) proteins family, as a new transcriptional target of E2F1.	Arginine	78-81	serine and arginine rich splicing factor 2	Homo sapiens	31-51
18992153-3	2008	In murine PGCs, expression and interaction of Blimp1 and Prmt5 results in arginine 3 dimethylation of histone H2A and H4.	Arginine	74-82	PR domain containing 1, with ZNF domain	Mus musculus	46-52
18992153-3	2008	In murine PGCs, expression and interaction of Blimp1 and Prmt5 results in arginine 3 dimethylation of histone H2A and H4.	Arginine	74-82	protein arginine N-methyltransferase 5	Mus musculus	57-62
18815228-0	2008	Essential role of EP3 subtype in prostaglandin E2-induced adhesion of mouse cultured and peritoneal mast cells to the Arg-Gly-Asp-enriched matrix.	Arginine	118-121	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	18-21
18555806-1	2008	Nitric oxide (NO), synthesized from l-arginine by tetrahydrobiopterin (BH4)-dependent NO synthase (NOS), is critical for neurological and muscular development and function.	Arginine	36-46	nitric oxide synthase 3	Sus scrofa	86-97
18765262-1	2008	Pyrogultamylated arginine-phenylalanineamide peptide (QRFP) is strongly conserved across species and is a member of the family of RFamide-related peptides, with the motif Arg-Phe-NH(2) at the C-terminal end.	Arginine	171-174	pyroglutamylated RFamide peptide	Rattus norvegicus	54-58
18755153-3	2008	In this work, we explored this unusual TRPV1 CaM-binding motif in detail and found that five residues from a putative CaM-binding motif are important for TRPV1-CT"s binding to CaM, with arginine R785 being the most essential residue.	Arginine	186-194	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-44
18755153-3	2008	In this work, we explored this unusual TRPV1 CaM-binding motif in detail and found that five residues from a putative CaM-binding motif are important for TRPV1-CT"s binding to CaM, with arginine R785 being the most essential residue.	Arginine	186-194	transient receptor potential cation channel subfamily V member 1	Homo sapiens	154-159
18782573-8	2008	Treatment with L-arginine significantly decreased blood pressure, concomitantly with an increase in the level of NO and the synthesis and release of CGRP in SHRs, but it did not affect ADMA levels.	Arginine	15-25	calcitonin-related polypeptide alpha	Rattus norvegicus	149-153
18832703-3	2008	The sequence of residues 111-129 of MBP (MBP(111-129)) differs in humans (MBP122:Arg) and mice (MBP122:Lys) at aa 122.	Arginine	81-84	myelin basic protein	Homo sapiens	36-39
18832703-3	2008	The sequence of residues 111-129 of MBP (MBP(111-129)) differs in humans (MBP122:Arg) and mice (MBP122:Lys) at aa 122.	Arginine	81-84	myelin basic protein	Homo sapiens	41-44
18832703-4	2008	We previously found that approximately 50% of human MBP(111-129) (MBP122:Arg)-specific T cell clones, including MS2-3C8 can proliferate in response to mouse MBP(111-129) (MBP122:Lys).	Arginine	73-76	myelin basic protein	Homo sapiens	52-55
18832703-4	2008	We previously found that approximately 50% of human MBP(111-129) (MBP122:Arg)-specific T cell clones, including MS2-3C8 can proliferate in response to mouse MBP(111-129) (MBP122:Lys).	Arginine	73-76	myelin basic protein	Homo sapiens	66-69
18280134-1	2008	Ornithine aminotransferase (OAT) is a crucial enzyme in the synthesis of citrulline and arginine from glutamine/glutamate and proline by enterocytes of the small intestine.	Arginine	88-96	ornithine aminotransferase	Homo sapiens	28-31
18817562-3	2008	Arginase I-producing myeloid derived suppressor cells have been shown to inhibit T-cell function by the depletion of L-arginine.	Arginine	117-127	arginase, liver	Mus musculus	0-10
18664629-0	2008	Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs.	Arginine	25-28	adrenoceptor beta 1	Homo sapiens	66-91
15992786-0	2005	Oral L-arginine supplementation ameliorates urinary risk factors and kinetic modulation of Tamm-Horsfall glycoprotein in experimental hyperoxaluric rats.	Arginine	5-15	uromodulin	Rattus norvegicus	91-117
15992786-2	2005	We determined whether l-arg supplementation safeguards the renal epithelial cell damage induced by hyperoxaluria with excretion of urinary marker enzymes and lithogenic salts with special reference to Tamm-Horsfall glycoprotein (THP).	Arginine	22-27	uromodulin	Rattus norvegicus	229-232
15992786-13	2005	In spectrophotometric crystallization assay system, l-arg supplemented rat THP showed inhibition in nucleation and aggregation phases, whereas EG-treated rat THP showed promotion of both calcium oxalate nucleation and aggregation phases.	Arginine	52-57	uromodulin	Rattus norvegicus	75-78
15992786-14	2005	In calcium-(14)C-oxalate binding assay, THP derived from hyperoxaluric rats exhibited 2-fold increase (p&lt;0.001) in the Ca*Ox binding when compared to control and l-arg supplemented animals.	Arginine	165-170	uromodulin	Rattus norvegicus	40-43
15992786-15	2005	CONCLUSIONS: l-Arg could act as a potent antilithic agent, by increasing the level of citrate in the hyperoxaluria-induced rats and decreasing calcium oxalate binding to the THP.	Arginine	13-18	uromodulin	Rattus norvegicus	174-177
18698489-3	2008	Although it has been observed that arginine residues in EWS are dimethylated in vivo, the endogenous enzyme(s) responsible for this reaction have not been identified to date.	Arginine	35-43	EWS RNA binding protein 1	Homo sapiens	56-59
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	EWS RNA binding protein 1	Homo sapiens	41-44
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	EWS RNA binding protein 1	Homo sapiens	163-166
18617565-8	2008	SNAP or 8Br-cGMP strongly suppressed TRPC6-like cation currents and membrane depolarization evoked by Arg(8)-vasopressin in A7r5 myocytes.	Arginine	102-105	transient receptor potential cation channel subfamily C member 6	Homo sapiens	37-42
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	100-108	H2A.X variant histone	Homo sapiens	232-236
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	127-130	H2A.X variant histone	Homo sapiens	232-236
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	141-144	H2A.X variant histone	Homo sapiens	232-236
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	81-84	protein arginine methyltransferase 4A	Arabidopsis thaliana	12-20
16087361-1	2005	Nitric oxide (NO), which is produced from l-arginine by three isoforms of NO synthase (NOS), has been implicated in reproductive functions.	Arginine	42-52	nitric oxide synthase 1, neuronal	Mus musculus	74-85
15945061-0	2005	Methylphenidate analogs with behavioral differences interact differently with arginine residues on the dopamine transporter in rat striatum.	Arginine	78-86	solute carrier family 6 member 3	Rattus norvegicus	103-123
15945061-2	2005	Herein, we report that methylphenidate and N-methyl-4-methyl-methylphenidate, but not N-benzylmethylphenidate, protect the rat striatal DAT from the arginine-selective chemical modifying agent, phenylglyoxal.	Arginine	149-157	solute carrier family 6 member 3	Rattus norvegicus	136-139
16007713-0	2005	C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions.	Arginine	145-153	galectin 3	Homo sapiens	90-100
15836435-5	2005	The importance of ERK1/2 for transcriptional synergy was demonstrated by transfection of a dominant-negative ERK1(K71R) mutant (where K71R stands for Lys71--&gt;Arg), which resulted in a reduced level of synergy on a CYP24 promoter-luciferase construct.	Arginine	161-164	mitogen activated protein kinase 3	Rattus norvegicus	18-24
16051872-4	2005	Here, we show that two clusters of arginine residues within capsid are required for stable binding to p32.	Arginine	35-43	complement C1q binding protein	Homo sapiens	102-105
15780765-11	2005	In summary, arginase-1 overexpression leads to upregulated CAT-1 expression in psoriatic skin, which is due to lowered intracellular l-arginine levels and limits NO synthesis at physiological l-arginine concentrations.	Arginine	192-202	arginase 1	Homo sapiens	12-22
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	88-91	protein arginine methyltransferase 4A	Arabidopsis thaliana	12-20
16051872-6	2005	Recombinant viruses encoding arginine-to-alanine mutations in the p32-binding region of capsid exhibited altered plaque morphology and replicated to lower titers.	Arginine	29-37	complement C1q binding protein	Homo sapiens	66-69
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	88-91	protein arginine methyltransferase 4A	Arabidopsis thaliana	12-20
18660432-8	2008	Finally, we found that asymmetric methylation at Arg-17 of histone H3 was greatly reduced in atprmt4a atprmt4b double mutants.	Arginine	49-52	protein arginine methyltransferase 4A	Arabidopsis thaliana	93-101
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Arginine	36-39	ribosomal protein S21	Homo sapiens	41-45
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Arginine	36-39	ribosomal protein S21	Homo sapiens	106-143
19035264-5	2008	Being as a NO donator, L-Arg significantly enhanced the ability of TNF-alpha which increasing permeability of strial capillary endothelial cells; permeation rate to Evans blue heightened significantly (P &lt; 0.01), which obviously rose up when the concentration of Evans blue added.	Arginine	23-28	tumor necrosis factor	Cavia porcellus	67-76
15680477-1	2005	The hexapeptide Thr-Gly-Glu-Asn-His-Arg (HLDF-6), which was first identified as an active fragment of the human leukemia differentiation factor (HLDF) molecule, displays differentiation-inducing, neuroprotective and anti-drug abuse activities.	Arginine	36-39	ribosomal protein S21	Homo sapiens	145-149
15799735-3	2005	RESULTS: Two molecular defects found in the NDP gene were: a missense mutation (265C > G) within codon 97 that resulted in the interchange of arginine by proline, and a partial deletion in the untranslated 3" region of exon 3 of the NDP gene.	Arginine	142-150	norrin cystine knot growth factor NDP	Homo sapiens	44-47
15917233-2	2005	Recombinant full-length ISG15 has been produced for the first time in high yield by mutating Cys78 to stabilize the protein and by cloning in a C-terminal arginine cap to protect the C terminus against proteolytic inactivation.	Arginine	155-163	ISG15 ubiquitin like modifier	Homo sapiens	24-29
15908697-7	2005	Molecular modeling of the Rad51-G103E mutant protein shows that the negatively charged glutamate residue lies on the surface of the N-terminal domain facing a positively charged patch composed of Arg-260, His-302, and Lys-305 on the ATPase core domain.	Arginine	196-199	recombinase RAD51	Saccharomyces cerevisiae S288C	26-31
19035264-7	2008	TNF-alpha decreased F-actin in strial capillary endothelial cells (P &lt; 0.01), more TNF-alpha, less F-actin; L-Arg could be further the inhibition to F-actin content (P &lt; 0.05); L-NMMA held back the trend (P &lt; 0.05).	Arginine	111-116	tumor necrosis factor	Cavia porcellus	0-9
16020259-1	2005	PURPOSE: Tissue plasminogen activator (tPA) is an efficient thrombolytic agent, but the dose-dependent retinal toxicity of intravitreal injection of commercial tPA (containing L-arginine) has been reported.	Arginine	176-186	plasminogen activator, tissue	Mus musculus	9-37
16020259-1	2005	PURPOSE: Tissue plasminogen activator (tPA) is an efficient thrombolytic agent, but the dose-dependent retinal toxicity of intravitreal injection of commercial tPA (containing L-arginine) has been reported.	Arginine	176-186	plasminogen activator, tissue	Mus musculus	39-42
18539895-10	2008	Studies with recombinant PF4 suggest a role for arginine 49 in stabilizing PF4-chondroitin binding.	Arginine	48-56	platelet factor 4	Homo sapiens	25-28
16020259-1	2005	PURPOSE: Tissue plasminogen activator (tPA) is an efficient thrombolytic agent, but the dose-dependent retinal toxicity of intravitreal injection of commercial tPA (containing L-arginine) has been reported.	Arginine	176-186	plasminogen activator, tissue	Mus musculus	160-163
16020259-8	2005	L-arginine seems to be the major factor in retinal toxicity of commercial tPA (containing L-arginine).	Arginine	0-10	plasminogen activator, tissue	Mus musculus	74-77
16020259-8	2005	L-arginine seems to be the major factor in retinal toxicity of commercial tPA (containing L-arginine).	Arginine	90-100	plasminogen activator, tissue	Mus musculus	74-77
16020259-9	2005	The formation of NO was markedly increased in mouse retinal cell cultures treated with tPA (containing L-arginine) or L-arginine.	Arginine	103-113	plasminogen activator, tissue	Mus musculus	87-90
16020259-11	2005	CONCLUSIONS: This study suggests that l-arginine from commercial tPA (containing L-arginine) induces the majority of cell death in mouse retinal cell cultures and that its cytotoxicity may depend on the induction of NO.	Arginine	38-48	plasminogen activator, tissue	Mus musculus	65-68
16020259-11	2005	CONCLUSIONS: This study suggests that l-arginine from commercial tPA (containing L-arginine) induces the majority of cell death in mouse retinal cell cultures and that its cytotoxicity may depend on the induction of NO.	Arginine	81-91	plasminogen activator, tissue	Mus musculus	65-68
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Arginine	155-163	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	50-54
15994821-2	2005	An analysis of the human genome demonstrated that ERV3 is one of a group of 41 highly related elements (ERV3-like HERVs) which use proline, isoleucine, or arginine tRNA in their primer binding sites.	Arginine	155-163	endogenous retrovirus group 3 member 1, envelope	Homo sapiens	104-108
18539895-10	2008	Studies with recombinant PF4 suggest a role for arginine 49 in stabilizing PF4-chondroitin binding.	Arginine	48-56	platelet factor 4	Homo sapiens	75-78
15623519-8	2005	Crystal structures of PTP domains demonstrated that the orientation of the absolutely conserved PTP loop arginine correlates with oxidizability of PTPs, and consistently, RPTPmu-D1, with a similar conformation as RPTPalpha-D1, was not readily oxidized.	Arginine	105-113	protein tyrosine phosphatase receptor type U	Homo sapiens	22-25
18599867-7	2008	Indeed, Rac1 promotes eNOS gene transcription through p21-activated kinase but not NADPH oxidase, increases eNOS mRNA stability, and enhances eNOS activity by promoting endothelial uptake of l-arginine.	Arginine	191-201	Rac family small GTPase 1	Mus musculus	8-12
15623519-8	2005	Crystal structures of PTP domains demonstrated that the orientation of the absolutely conserved PTP loop arginine correlates with oxidizability of PTPs, and consistently, RPTPmu-D1, with a similar conformation as RPTPalpha-D1, was not readily oxidized.	Arginine	105-113	protein tyrosine phosphatase receptor type U	Homo sapiens	96-99
15623519-8	2005	Crystal structures of PTP domains demonstrated that the orientation of the absolutely conserved PTP loop arginine correlates with oxidizability of PTPs, and consistently, RPTPmu-D1, with a similar conformation as RPTPalpha-D1, was not readily oxidized.	Arginine	105-113	6-pyruvoyltetrahydropterin synthase	Homo sapiens	147-151
15623519-8	2005	Crystal structures of PTP domains demonstrated that the orientation of the absolutely conserved PTP loop arginine correlates with oxidizability of PTPs, and consistently, RPTPmu-D1, with a similar conformation as RPTPalpha-D1, was not readily oxidized.	Arginine	105-113	protein tyrosine phosphatase receptor type A	Homo sapiens	213-222
15623519-9	2005	In conclusion, PTPs are differentially oxidized at physiological pH and H(2)O(2) concentrations, and the PTP loop arginine is an important determinant for susceptibility to oxidation.	Arginine	114-122	6-pyruvoyltetrahydropterin synthase	Homo sapiens	15-19
15623519-9	2005	In conclusion, PTPs are differentially oxidized at physiological pH and H(2)O(2) concentrations, and the PTP loop arginine is an important determinant for susceptibility to oxidation.	Arginine	114-122	protein tyrosine phosphatase receptor type U	Homo sapiens	15-18
18572269-7	2008	The rat mast cell line RBL-2H3 were most efficiently transduced with a fiber-mutant Ad5 vector containing the Arg-Gly-Asp (RGD) peptide in the HI loop (Ad-RGD) of the fiber knob.	Arginine	110-113	Alzheimer disease, familial, type 5	Homo sapiens	84-87
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Arginine	75-83	SMAD family member 4	Homo sapiens	16-21
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Arginine	75-83	SMAD family member 4	Homo sapiens	103-108
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Arginine	75-83	death domain associated protein	Homo sapiens	109-113
15546957-1	2005	The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an important determinant of the inflammatory response of murine macrophages and dendritic cells.	Arginine	15-23	nitric oxide synthase 1, neuronal	Mus musculus	39-60
18670643-2	2008	A common polymorphism of FGFR-4 in which arginine (Arg(388)) replaces glycine (Gly(388)) at amino acid 388 is associated with progression in human prostate cancer.	Arginine	41-49	fibroblast growth factor receptor 4	Homo sapiens	25-31
15736962-3	2005	MBP consists of a number of posttranslationally modified isoforms of varying charge, including C8, in which six arginines are deiminated to the uncharged residue citrulline.	Arginine	112-121	myelin basic protein	Homo sapiens	0-3
18670643-2	2008	A common polymorphism of FGFR-4 in which arginine (Arg(388)) replaces glycine (Gly(388)) at amino acid 388 is associated with progression in human prostate cancer.	Arginine	51-54	fibroblast growth factor receptor 4	Homo sapiens	25-31
15731352-4	2005	Here, we report that CARM1 also methylates Arg-2142 within the C-terminal GRIP1 binding domain (GBD) of p300.	Arginine	43-46	E1A binding protein p300	Homo sapiens	104-108
18670643-3	2008	We show that the FGFR-4 Arg(388) polymorphism, which is present in most prostate cancer patients, results in increased receptor stability and sustained receptor activation.	Arginine	24-27	fibroblast growth factor receptor 4	Homo sapiens	17-23
15731352-6	2005	Methylation of Arg-2142 inhibits the bimolecular interaction of GRIP1 to p300 in vitro and in vivo.	Arginine	15-18	E1A binding protein p300	Homo sapiens	73-77
18456004-2	2008	Nitric oxide (NO), shown to have protective effects in I/R, is produced by nitric oxide synthase (NOS) from the substrate arginine.	Arginine	122-130	nitric oxide synthase 1, neuronal	Mus musculus	75-96
18399795-9	2008	Based on CASQ2 models, we propose that the Arg(33)--&gt;Gln exchange made the Ca(2+)-dependent formation of front-to-front dimers more difficult, whereas the Leu(167)--&gt;His replacement almost completely inhibited back-to-back dimer interactions.	Arginine	43-46	calsequestrin 2	Homo sapiens	9-14
15732101-5	2005	We have identified four mutations in senataxin in the French-Canadian population including two novel missense mutations: the 5927T--&gt;G mutation changes the leucine encoded by codon 1976 to an arginine in the helicase domain (L1976R), and the 193G--&gt;A mutation changes a glutamic acid encoded by codon 65 into a lysine in the N-terminal domain of the protein (E65K).	Arginine	195-203	senataxin	Homo sapiens	37-46
15683683-8	2005	Moreover, l-arginine enhanced productions of both the latter produced TNF-alpha and PGE2 from burnt macrophages, and the expressions of TNF-alpha and COX-2 were improved significantly, while l-NMMA did reverse ways.	Arginine	10-20	cytochrome c oxidase II, mitochondrial	Mus musculus	150-155
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Arginine	142-150	E1A binding protein p300	Homo sapiens	38-42
15569683-5	2005	In contrast, another mutant of TDGb (TDGb(KR)) in which the lysine residue targeted for SUMO-1 conjugation is replaced with arginine retained the ability to bind SUMO-1 non-covalently.	Arginine	124-132	small ubiquitin like modifier 1	Homo sapiens	162-168
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Arginine	142-150	tyrosine aminotransferase	Homo sapiens	101-104
18413142-2	2008	Using hexameric peptide library of FN-III(8-11) scan, we identified the ALNGR (Ala-Leu-Asn-Gly-Arg) peptide that induced cell adhesion as well as RGDS (Arg-Gly-Asp-Ser) peptide.	Arginine	95-98	ral guanine nucleotide dissociation stimulator	Homo sapiens	146-150
15701008-0	2005	Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.	Arginine	153-161	galectin 3	Homo sapiens	105-115
18358546-0	2008	The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor.	Arginine	75-83	complement C1q binding protein	Homo sapiens	28-34
15639231-2	2005	Here we report the cloning, purification, and characterization of the C-terminal glycine/arginine-rich (GAR) domain of pea nucleolin.	Arginine	89-97	nucleolin	Homo sapiens	123-132
18358546-4	2008	Then, construction of a mutant receptor in i3 loop allowed us to identify the i3 loop arginine cluster of the vasopressin V(2) receptor as the interacting determinant for GC1q-R interaction.	Arginine	86-94	complement C1q binding protein	Homo sapiens	171-177
18358546-5	2008	Using purified receptor as a bait and recombinant (74-282) GC1q-R, we demonstrated a direct and specific interaction between these two proteins via the arginine cluster.	Arginine	152-160	complement C1q binding protein	Homo sapiens	59-65
15652243-7	2005	The Arg(163) is located in a highly conserved region of the human TPMT protein and, as such, the Arg(163)His substitution is expected to result in a marked reduction of enzyme activity, as confirmed by the in vitro data.	Arginine	4-7	thiopurine S-methyltransferase	Homo sapiens	66-70
18413672-3	2008	As we have demonstrated before, these effects are mediated in part through inhibition of neuronal nitric oxide synthase (nNOS), resulting in increased availability of arginine.	Arginine	167-175	nitric oxide synthase 1, neuronal	Mus musculus	121-125
18511645-0	2008	Use of long-acting beta2 agonists in arginine-16 homozygous patients with asthma.	Arginine	37-45	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	19-24
15734954-5	2005	The common alleles of the CYP1B1 gene were Arg (79.97%) in codon 48, Ala (80.53%) in codon 119, and Leu (86.57%) in codon 432.	Arginine	43-46	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	26-32
15681431-0	2005	The adenovirus E4-6/7 protein directs nuclear localization of E2F-4 via an arginine-rich motif.	Arginine	75-83	transcription factor 3	Homo sapiens	15-21
18472002-0	2008	Arginine methylation of hnRNP K enhances p53 transcriptional activity.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	24-31
15681431-0	2005	The adenovirus E4-6/7 protein directs nuclear localization of E2F-4 via an arginine-rich motif.	Arginine	75-83	E2F transcription factor 4	Homo sapiens	62-67
15681431-7	2005	This redirection of E2F-4 from cytoplasm to the nucleus requires an N-terminal arginine-rich nuclear localization sequence within E4-6/7.	Arginine	79-87	E2F transcription factor 4	Homo sapiens	20-25
18472002-1	2008	Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53.	Arginine	77-85	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	39-46
15681431-7	2005	This redirection of E2F-4 from cytoplasm to the nucleus requires an N-terminal arginine-rich nuclear localization sequence within E4-6/7.	Arginine	79-87	transcription factor 3	Homo sapiens	130-136
18472002-2	2008	In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation.	Arginine	53-61	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	32-39
18472002-3	2008	Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53.	Arginine	13-21	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	37-44
18472002-5	2008	These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity.	Arginine	26-34	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	50-57
17912498-8	2008	Our results revealed that urinary 8-OHdG level was higher in chewers with SULT1A1 Arg-His genotype than in chewers with SULT1A1 Arg-Arg genotype.	Arginine	82-85	sulfotransferase family 1A member 1	Homo sapiens	74-81
15693859-7	2005	GSH-Px and GR activities were increased in the untreated, the L-arginine and the L-carnitine-treated H/R groups when compared to the control group.	Arginine	62-72	glutathione reductase	Mus musculus	11-13
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	193-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	193-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15921163-0	2005	A novel mutation of the alpha2-globin causing alpha(+)-thalassemia: Hb Plasencia [alpha125(H8)Leu--Arg (alpha2).	Arginine	99-102	hemoglobin subunit alpha 2	Homo sapiens	24-37
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	99-102	acetylcholinesterase	Mus musculus	6-10
15632042-1	2005	UNLABELLED: The purpose of this study was to examine the therapeutic efficacy of (188)Re-(Arg(11))[Cys(3,4,10),d-Phe(7)]alpha-melanocyte-stimulating hormone(3-13) (CCMSH) in the B16/F1 murine melanoma- and TXM13 human melanoma-bearing mouse models.	Arginine	90-93	pro-opiomelanocortin-alpha	Mus musculus	120-156
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	acetylcholinesterase	Mus musculus	6-10
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	acetylcholinesterase	Mus musculus	6-10
15635723-0	2005	Efficient synthesis and comparative studies of the arginine and Nomega,Nomega-dimethylarginine forms of the human nucleolin glycine/arginine rich domain.	Arginine	86-94	nucleolin	Homo sapiens	114-123
15635723-1	2005	The Gly- and Arg-rich C-terminal region of human nucleolin is a 61-residue long domain involved in a number of protein-protein and protein-nucleic acid interactions.	Arginine	13-16	nucleolin	Homo sapiens	49-58
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	acetylcholinesterase	Mus musculus	6-10
15840963-1	2005	CPR has the carboxypeptidase B-like activity that can inactivate the inflammatory peptides such as C5a by removing the C-terminal arginine and can interfere with fibrinolysis by removing C-terminal lysine residue of fibrin.	Arginine	130-138	carboxypeptidase B1 (tissue)	Mus musculus	12-30
18215127-8	2008	Docking showed the major component of the interaction site on AChE to be the acidic sequence Arg(90)-Glu-Leu-Ser-Glu-Asp(95) on the omega loop, and also the involvement of Pro(40)-Pro-Val(42), Arg(46) (linked to Glu(94) by a salt bridge) and the hexapeptide Asp(61)-Ala-Thr-Thr-Phe-Gln(66).	Arginine	93-96	acetylcholinesterase	Mus musculus	62-66
18215127-8	2008	Docking showed the major component of the interaction site on AChE to be the acidic sequence Arg(90)-Glu-Leu-Ser-Glu-Asp(95) on the omega loop, and also the involvement of Pro(40)-Pro-Val(42), Arg(46) (linked to Glu(94) by a salt bridge) and the hexapeptide Asp(61)-Ala-Thr-Thr-Phe-Gln(66).	Arginine	193-196	acetylcholinesterase	Mus musculus	62-66
18249022-7	2008	However, the Arg-allele was associated with a slightly increased risk of type 2 diabetes (OR1.15 (CI: 1.01-1.31); p=0.04), increased insulin resistance estimated by homeostasis model assessment (p=0.01), higher fasting serum insulin levels (p=0.01), and higher levels of plasma glucose 2-h after glucose ingestion (p=0.02).	Arginine	13-16	olfactory receptor family 7 subfamily E member 14 pseudogene	Homo sapiens	90-96
15604266-6	2004	These arginines were also required for endostatin to inhibit fibroblast growth factor-2- and vascular endothelial growth factor-A-induced chemotaxis of primary endothelial cells.	Arginine	6-15	fibroblast growth factor 2	Gallus gallus	61-87
18249022-9	2008	Furthermore, the Arg-allele was borderline associated with type 2 diabetes in a meta-analysis of the present and 26 previous studies (p=0.06, OR1.27 (CI: 0.99-1.63)) (n=18891).	Arginine	17-20	olfactory receptor family 10 subfamily P member 1	Homo sapiens	142-148
15530866-0	2004	MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1).	Arginine	22-30	myogenin	Homo sapiens	143-151
18401503-0	2008	High-level QM/MM modelling predicts an arginine as the acid in the condensation reaction catalysed by citrate synthase.	Arginine	39-47	citrate synthase	Homo sapiens	102-118
18401503-1	2008	High-level ab initio quantum mechanical/molecular mechanical (QM/MM) modelling of citryl-CoA formation in citrate synthase reveals that an arginine residue acts as the proton donor; this proposed new mechanism helps to explain how chemical and large scale conformational changes are coupled in this paradigmatic enzyme.	Arginine	139-147	citrate synthase	Homo sapiens	106-122
15337738-2	2004	The kinetic parameters for individual APC-mediated cleavages in FVa, i.e. at Arg-306 and Arg-506, were investigated at high and low phospholipid concentrations in the presence and absence of protein S. FVa variants 306Q679Q and 506Q679Q, which can only be cleaved at Arg-506 and Arg-306, respectively, were used.	Arginine	77-80	APC regulator of WNT signaling pathway	Homo sapiens	38-41
15337738-2	2004	The kinetic parameters for individual APC-mediated cleavages in FVa, i.e. at Arg-306 and Arg-506, were investigated at high and low phospholipid concentrations in the presence and absence of protein S. FVa variants 306Q679Q and 506Q679Q, which can only be cleaved at Arg-506 and Arg-306, respectively, were used.	Arginine	89-92	APC regulator of WNT signaling pathway	Homo sapiens	38-41
18309292-0	2008	The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.	Arginine	71-79	RAP1 GTPase activating protein	Homo sapiens	8-14
15337738-2	2004	The kinetic parameters for individual APC-mediated cleavages in FVa, i.e. at Arg-306 and Arg-506, were investigated at high and low phospholipid concentrations in the presence and absence of protein S. FVa variants 306Q679Q and 506Q679Q, which can only be cleaved at Arg-506 and Arg-306, respectively, were used.	Arginine	89-92	APC regulator of WNT signaling pathway	Homo sapiens	38-41
15337738-2	2004	The kinetic parameters for individual APC-mediated cleavages in FVa, i.e. at Arg-306 and Arg-506, were investigated at high and low phospholipid concentrations in the presence and absence of protein S. FVa variants 306Q679Q and 506Q679Q, which can only be cleaved at Arg-506 and Arg-306, respectively, were used.	Arginine	89-92	APC regulator of WNT signaling pathway	Homo sapiens	38-41
15337738-3	2004	In the absence of protein S, QGNSEDY-APC was 17.8- and 4-fold more efficient than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	104-107	APC regulator of WNT signaling pathway	Homo sapiens	37-40
15337738-3	2004	In the absence of protein S, QGNSEDY-APC was 17.8- and 4-fold more efficient than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	104-107	APC regulator of WNT signaling pathway	Homo sapiens	85-88
15337738-3	2004	In the absence of protein S, QGNSEDY-APC was 17.8- and 4-fold more efficient than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	116-119	APC regulator of WNT signaling pathway	Homo sapiens	37-40
15337738-3	2004	In the absence of protein S, QGNSEDY-APC was 17.8- and 4-fold more efficient than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	116-119	APC regulator of WNT signaling pathway	Homo sapiens	85-88
15337738-5	2004	In the presence of protein S, QGNSEDYAPC was 6.8- and 3.2-fold more active than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	102-105	APC regulator of WNT signaling pathway	Homo sapiens	37-40
15337738-5	2004	In the presence of protein S, QGNSEDYAPC was 6.8- and 3.2-fold more active than WT-APC in cleaving at Arg-306 and Arg-506, respectively, at high phospholipid.	Arginine	114-117	APC regulator of WNT signaling pathway	Homo sapiens	37-40
15337738-7	2004	In conclusion, the modification of the Gla domain in QGNSEDY-APC yielded increased rates of cleavage at both sites in FVa, the increase being particularly pronounced for the Arg-306 site in the absence of protein S. The results obtained with QGNSEDY-APC provide insights into the importance of the APC-phospholipid interaction for the APC-mediated cleavages at Arg-306 and Arg-506 in FVa.	Arginine	174-177	APC regulator of WNT signaling pathway	Homo sapiens	61-64
15337738-7	2004	In conclusion, the modification of the Gla domain in QGNSEDY-APC yielded increased rates of cleavage at both sites in FVa, the increase being particularly pronounced for the Arg-306 site in the absence of protein S. The results obtained with QGNSEDY-APC provide insights into the importance of the APC-phospholipid interaction for the APC-mediated cleavages at Arg-306 and Arg-506 in FVa.	Arginine	361-364	APC regulator of WNT signaling pathway	Homo sapiens	61-64
15337738-7	2004	In conclusion, the modification of the Gla domain in QGNSEDY-APC yielded increased rates of cleavage at both sites in FVa, the increase being particularly pronounced for the Arg-306 site in the absence of protein S. The results obtained with QGNSEDY-APC provide insights into the importance of the APC-phospholipid interaction for the APC-mediated cleavages at Arg-306 and Arg-506 in FVa.	Arginine	361-364	APC regulator of WNT signaling pathway	Homo sapiens	61-64
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	221-224	fibroblast growth factor receptor 4	Homo sapiens	48-85
18391212-5	2008	This binding mode appears to be driven by the presence of a carboxylate on MFA-1 that is situated to make a salt-bridge interaction with an arginine residue in the FXR-binding pocket that is normally used to neutralize bound bile acids.	Arginine	140-148	nuclear receptor subfamily 1 group H member 4	Homo sapiens	164-167
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	221-224	fibroblast growth factor receptor 4	Homo sapiens	87-92
15981099-6	2005	FGFR4 genotyping revealed the presence of the Arg(388) in 72% of the eighteen GC cases, a frequency similar to the one found in 21 common astrocytomas (71%).	Arginine	46-49	fibroblast growth factor receptor 4	Homo sapiens	0-5
15339932-7	2004	Molecular modeling revealed Arg-310 of NEIL2 to be a critical residue in its zinc binding pocket, which is highly conserved throughout the Fpg/Nei family.	Arginine	28-31	nei like DNA glycosylase 2	Homo sapiens	39-44
15488116-4	2004	Nitric oxide synthase (NOS) activity was evaluated via formation of L-citrulline from L-arginine.	Arginine	86-96	nitric oxide synthase, inducible	Cavia porcellus	0-21
18250167-5	2008	Based on the crystal structures of Kir3.1 and KirBac1.1, Arg-301 interacts with several residues in the neighboring Kir6.2 subunit.	Arginine	57-60	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	35-41
15716048-6	2005	The inhibition of ODC activity in cells exposed to L-methionine or L-arginine was due to a decreased abundance of ODC protein without change at the mRNA level and each of these amino acids could counteract ODC induction by a glycine supplement.	Arginine	67-77	ornithine decarboxylase 1	Homo sapiens	18-21
15716048-6	2005	The inhibition of ODC activity in cells exposed to L-methionine or L-arginine was due to a decreased abundance of ODC protein without change at the mRNA level and each of these amino acids could counteract ODC induction by a glycine supplement.	Arginine	67-77	ornithine decarboxylase 1	Homo sapiens	114-117
15716048-6	2005	The inhibition of ODC activity in cells exposed to L-methionine or L-arginine was due to a decreased abundance of ODC protein without change at the mRNA level and each of these amino acids could counteract ODC induction by a glycine supplement.	Arginine	67-77	ornithine decarboxylase 1	Homo sapiens	114-117
15716048-7	2005	Contrary to the latter, supplemental L-methionine or L-arginine induced a marked decrease in ODC half-life, concomitantly with an increase in the activity of antizyme, an ODC inhibitory protein.	Arginine	53-63	ornithine decarboxylase 1	Homo sapiens	93-96
15716048-7	2005	Contrary to the latter, supplemental L-methionine or L-arginine induced a marked decrease in ODC half-life, concomitantly with an increase in the activity of antizyme, an ODC inhibitory protein.	Arginine	53-63	ornithine decarboxylase 1	Homo sapiens	171-174
18370414-7	2008	The reduction of CB1954 catalyzed by the neuronal NOS (nNOS) was inhibited by O 2 and a flavin/NADPH binding inhibitor, diphenyliodonium (DPI), but insensitive to the addition of the heme ligands imidazole and carbon monoxide and of l-arginine analogues.	Arginine	233-243	nitric oxide synthase 1	Homo sapiens	41-53
15894612-4	2005	Selective mutation of one of the basic TM residues of NKG2D resulted in loss of two DAP10 chains, indicating that each TM arginine serves as an interaction site for a DAP10 dimer.	Arginine	122-130	killer cell lectin like receptor K1	Homo sapiens	54-59
15894612-7	2005	Formation of a three-helix interface among the TM domains involved ionizable residues from all three chains, the TM arginine of NKG2D and both TM aspartic acids of the DAP10 dimer.	Arginine	116-124	killer cell lectin like receptor K1	Homo sapiens	128-133
15479221-4	2004	METHODS: Frequencies of the following variants were assessed in extremely obese children and healthy underweight controls: Gly/Ser in codon 49 and Arg/Gly in codon 389 of the beta(1)-AR, Arg/Gly in codon 16 and Gln/Glu in codon 27 of the beta(2)-AR, Trp/Arg in codon 64 of the beta(3)-AR.	Arginine	147-150	adrenoceptor beta 1	Homo sapiens	175-185
18370414-7	2008	The reduction of CB1954 catalyzed by the neuronal NOS (nNOS) was inhibited by O 2 and a flavin/NADPH binding inhibitor, diphenyliodonium (DPI), but insensitive to the addition of the heme ligands imidazole and carbon monoxide and of l-arginine analogues.	Arginine	233-243	nitric oxide synthase 1	Homo sapiens	55-59
15292263-12	2004	Thus, the Rap.RapGAP catalytic machinery compensates for the absence of a cis-Gln by a trans-Asn and for the catalytic Arg by inducing a different GTP conformation that is more prone to be attacked by a water molecule.	Arginine	119-122	RAP1 GTPase activating protein	Homo sapiens	14-20
18426410-2	2008	We showed earlier that activation of PAR-2 with Ser-Leu-Ile-Gly-Arg-Leu-NH(2) (SLIGRL), a known PAR-2 activating peptide, induces keratinocyte phagocytosis and increases skin pigmentation, indicating that PAR-2 regulates pigmentation by controlling phagocytosis of melanosomes.	Arginine	64-67	F2R like trypsin receptor 1	Homo sapiens	37-42
15292262-9	2004	Mutation of the conserved Arg in the ligand binding site of Siglec-7 (Arg124) or Siglec-9 (Arg120) resulted in reduced inhibitory function in the NFAT/luciferase transcription assay, suggesting that ligand binding is required for optimal inhibition of TCR signaling.	Arginine	26-29	sialic acid binding Ig like lectin 7	Homo sapiens	60-68
15465783-2	2004	Major pathways for arginine production are protein breakdown and de novo arginine production from citrulline; disposal of arginine is mainly used for protein synthesis or used by the enzymes arginase and nitric oxide synthase (NOS).	Arginine	19-27	nitric oxide synthase 1, neuronal	Mus musculus	204-225
15914972-12	2005	Both CsA and L-NAME reduced urinary nitrate excretion, which was reversed by co-administration of L-Arg.	Arginine	98-103	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	5-8
15914972-13	2005	Co-administration of citrate or L-Arg improved the CsA- and L-NAME-induced acidosis and hyperkalemia.	Arginine	32-37	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	51-54
18426410-2	2008	We showed earlier that activation of PAR-2 with Ser-Leu-Ile-Gly-Arg-Leu-NH(2) (SLIGRL), a known PAR-2 activating peptide, induces keratinocyte phagocytosis and increases skin pigmentation, indicating that PAR-2 regulates pigmentation by controlling phagocytosis of melanosomes.	Arginine	64-67	F2R like trypsin receptor 1	Homo sapiens	96-101
18426410-2	2008	We showed earlier that activation of PAR-2 with Ser-Leu-Ile-Gly-Arg-Leu-NH(2) (SLIGRL), a known PAR-2 activating peptide, induces keratinocyte phagocytosis and increases skin pigmentation, indicating that PAR-2 regulates pigmentation by controlling phagocytosis of melanosomes.	Arginine	64-67	F2R like trypsin receptor 1	Homo sapiens	96-101
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	Janus kinase 2	Homo sapiens	118-122
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	Janus kinase 2	Homo sapiens	153-157
18359858-5	2008	Consistent with earlier biochemical data, KLK1 was shown to exhibit both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1", and Phe/Leu at P2.	Arginine	127-130	kallikrein 1	Homo sapiens	42-46
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	Janus kinase 2	Homo sapiens	153-157
15866322-6	2005	NO is formed from L-arginine via catalysis by NO synthase (NOS) isoforms, neuronal (nNOS), endothelial (eNOS), and inducible NOS.	Arginine	18-28	nitric oxide synthase 1	Homo sapiens	46-57
15866322-6	2005	NO is formed from L-arginine via catalysis by NO synthase (NOS) isoforms, neuronal (nNOS), endothelial (eNOS), and inducible NOS.	Arginine	18-28	nitric oxide synthase 1	Homo sapiens	84-88
15780765-5	2005	Furthermore, we tested the hypothesis that arginase-1 overexpression regulates CAT expression via intracellular l-arginine concentration.	Arginine	112-122	arginase 1	Homo sapiens	43-53
15780765-11	2005	In summary, arginase-1 overexpression leads to upregulated CAT-1 expression in psoriatic skin, which is due to lowered intracellular l-arginine levels and limits NO synthesis at physiological l-arginine concentrations.	Arginine	133-143	arginase 1	Homo sapiens	12-22
15448004-2	2004	A germline polymorphism of the FGFR-4 gene resulting in expression of arginine at codon 388 (Arg388) is associated with aggressive disease in patients with breast and colon cancer.	Arginine	70-78	fibroblast growth factor receptor 4	Homo sapiens	31-37
18359858-5	2008	Consistent with earlier biochemical data, KLK1 was shown to exhibit both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1, Ser/Arg strongly preferred at P1", and Phe/Leu at P2.	Arginine	157-160	kallikrein 1	Homo sapiens	42-46
18289604-6	2008	Exogenous ADMA significantly enhanced ROS production/MDA concentration and inhibited ALDH-2 activity, and overexpression of DDAH2 could significantly suppress GTN-induced oxidative stress and inhibition of ALDH-2 activity, which is also attenuated by L-arginine.	Arginine	251-261	aldehyde dehydrogenase 2 family member	Homo sapiens	206-212
15289616-4	2004	Mcm1p and Arg80p were found in a soluble complex lacking Arg81p and Arg82p, and both Mcm1p and Arg80p were efficiently recruited to ARG1 in wild-type cells in the presence or absence of exogenous arginine, and also in arg81Delta cells.	Arginine	196-204	arginase 1	Homo sapiens	132-136
15289616-7	2004	By recruiting an arginine-regulated repressor, Gcn4p can precisely modulate its activation function at ARG1 according to the availability of arginine.	Arginine	17-25	arginase 1	Homo sapiens	103-107
15289616-7	2004	By recruiting an arginine-regulated repressor, Gcn4p can precisely modulate its activation function at ARG1 according to the availability of arginine.	Arginine	141-149	arginase 1	Homo sapiens	103-107
15795423-7	2005	Results of the microarray analysis indicated that arginine supplementation increased adipose tissue expression of key genes responsible for fatty acid and glucose oxidation: NO synthase-1 (145%), heme oxygenase-3 (789%), AMP-activated protein kinase (123%), and peroxisome proliferator-activated receptor gamma coactivator-1alpha (500%).	Arginine	50-58	heme oxygenase (decycling) 2, pseudogene 1	Rattus norvegicus	196-212
18172012-6	2008	Point mutant analysis revealed that SET domain cysteine 483 and arginine 477 are critical residues for the histone methyltransferase (HMTase) activity of RE-IIBP.	Arginine	64-72	PR/SET domain 9	Homo sapiens	107-132
15611080-8	2005	A PTHrP-based analog ([p-benzoylphenylalanine1, Ile5,Arg(11,13),Tyr36]PTHrP-(1-36)NH2), which selectively activates the G(s)/cAMP pathway without inducing PTH1R endocytosis, failed to stimulate ERK1/2 activity.	Arginine	53-56	parathyroid hormone like hormone	Homo sapiens	2-7
15611080-8	2005	A PTHrP-based analog ([p-benzoylphenylalanine1, Ile5,Arg(11,13),Tyr36]PTHrP-(1-36)NH2), which selectively activates the G(s)/cAMP pathway without inducing PTH1R endocytosis, failed to stimulate ERK1/2 activity.	Arginine	53-56	parathyroid hormone like hormone	Homo sapiens	70-75
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Arginine	75-83	death domain associated protein	Homo sapiens	144-148
15637079-4	2005	Substitution of Smad4 SUMO conjugation residue lysine 159, but not 113, to arginine not only disrupted Smad4-Daxx interaction but also relieved Daxx-elicited repression of Smad4 transcriptional activity.	Arginine	75-83	SMAD family member 4	Homo sapiens	103-108
15741314-5	2005	Our results suggest that arginine methylation regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.	Arginine	25-33	RAD50 double strand break repair protein	Homo sapiens	78-83
15377272-1	2004	A comparative study of secondary specificities of enteropeptidase and trypsin was performed using peptide substrates with general formula A-(Asp/Glu)n-Lys(Arg)-(downward arrow)-B, where n = 1-4.	Arginine	155-158	transmembrane serine protease 15	Homo sapiens	50-65
15226270-6	2004	Site-directed mutagenesis of the linker region allowed us to identify the relevant determinants as Arg(740) and Val(741) residues for intracellular expression of TLR3.	Arginine	99-102	toll like receptor 3	Homo sapiens	162-166
18172012-6	2008	Point mutant analysis revealed that SET domain cysteine 483 and arginine 477 are critical residues for the histone methyltransferase (HMTase) activity of RE-IIBP.	Arginine	64-72	PR/SET domain 9	Homo sapiens	134-140
18359683-5	2008	Ghrelin also showed excitatory effect on the MMCs, which was inhibited by atropine, L-arginine or (D-Lys3)GHRP-6, but not by propranolol and phentolamine.	Arginine	84-94	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
15215498-3	2004	We sequenced candidate genes from the region and identified a missense mutation in the chondroitin 6-O-sulfotransferase (C6ST-1) gene (CHST3) changing an arginine into a glutamine (R304Q) in the well conserved 3"-phosphoadenosine 5"-phosphosulfate binding site.	Arginine	154-162	carbohydrate sulfotransferase 3	Homo sapiens	121-127
15215498-3	2004	We sequenced candidate genes from the region and identified a missense mutation in the chondroitin 6-O-sulfotransferase (C6ST-1) gene (CHST3) changing an arginine into a glutamine (R304Q) in the well conserved 3"-phosphoadenosine 5"-phosphosulfate binding site.	Arginine	154-162	carbohydrate sulfotransferase 3	Homo sapiens	135-140
15743275-0	2005	Interaction of the endothelial nitric oxide synthase with the CAT-1 arginine transporter enhances NO release by a mechanism not involving arginine transport.	Arginine	68-76	solute carrier family 7 member 1	Bos taurus	62-67
15743275-2	2005	Evidence has been presented previously that eNOS is associated with the CAT (cationic amino acid transporter)-1 arginine transporter in endothelial caveolae, and it has been proposed that eNOS-CAT-1 association facilitates the delivery of extracellular L-arginine to eNOS.	Arginine	253-263	solute carrier family 7 member 1	Bos taurus	193-198
15743275-6	2005	Overexpression of CAT-1 in BAECs by adenoviral-mediated gene transfer results in significant increases in both L-arginine uptake and NO production by the cells.	Arginine	111-121	solute carrier family 7 member 1	Bos taurus	18-23
15743275-9	2005	Taken together, these data suggest that direct interaction of eNOS with CAT-1 enhances NO release by a mechanism not involving arginine transport.	Arginine	127-135	solute carrier family 7 member 1	Bos taurus	72-77
15736962-0	2005	Effect of arginine loss in myelin basic protein, as occurs in its deiminated charge isoform, on mediation of actin polymerization and actin binding to a lipid membrane in vitro.	Arginine	10-18	myelin basic protein	Homo sapiens	27-47
18179643-2	2008	Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses.	Arginine	92-100	Fc gamma receptor IIa	Homo sapiens	108-113
15822564-4	2005	Affected cat 1 had a single nucleotide change in exon 8 at the 1st nucleotide position of the codon encoding an arginine (CGA to TGA) at amino acid position 338.	Arginine	112-120	glycoprotein hormones alpha chain	Felis catus	122-125
15180924-7	2004	Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport.	Arginine	162-170	solute carrier family 7 member 8 S homeolog	Xenopus laevis	56-60
15180924-7	2004	Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport.	Arginine	162-170	solute carrier family 7 member 8 S homeolog	Xenopus laevis	96-100
17998247-4	2008	We report here that KSRP is arginine methylated and interacts with the Tudor domain of SMN, the causative gene for spinal muscular atrophy (SMA), in a CARM1 methylation-dependent fashion.	Arginine	28-36	KH-type splicing regulatory protein	Rattus norvegicus	20-24
15208393-4	2004	In phs1-1, a conserved Arg residue in the noncatalytic N-terminal region is exchanged with Cys, and the mutant PHS1 retained considerable phosphatase activity in vitro.	Arginine	23-26	dual specificity protein phosphatase family protein	Arabidopsis thaliana	3-7
15208393-4	2004	In phs1-1, a conserved Arg residue in the noncatalytic N-terminal region is exchanged with Cys, and the mutant PHS1 retained considerable phosphatase activity in vitro.	Arginine	23-26	dual specificity protein phosphatase family protein	Arabidopsis thaliana	111-115
15743838-3	2005	Complex formation in vitro and in vivo requires a 63-residue glycine-arginine-rich (GAR) domain located at the extreme C terminus of nucleolin, with this domain sufficient to inhibit DNA replication in vitro.	Arginine	69-77	nucleolin	Homo sapiens	133-142
18077447-2	2008	Whereas substitution of arginine for the highly conserved glycine 193 in the trypsin active site has been implicated as a critical factor in the inhibitor resistance of mesotrypsin, how this substitution leads to accelerated inhibitor cleavage is not clear.	Arginine	24-32	serine protease 3	Homo sapiens	169-180
15542598-10	2005	When tau was phosphorylated by glycogen synthase kinase-3beta, most of these proteolytic processes were inhibited, except for the first cleavage at the Arg(155)-Gly(156) bond.	Arginine	152-155	glycogen synthase kinase 3 beta	Homo sapiens	31-61
15788111-1	2005	Transgenic mice that overexpress arginase-I in their small-intestinal enterocytes suffer from a pronounced, but selective decrease in circulating arginine levels during the suckling period, resulting in impaired growth and development of hair, muscle and immune system.	Arginine	146-154	arginase, liver	Mus musculus	33-43
15103693-0	2004	Covalent and noncovalent chemical modifications of arginine residues decrease dopamine transporter activity.	Arginine	51-59	solute carrier family 6 member 3	Rattus norvegicus	78-98
15103693-7	2004	Thus, Arg residues are important for DAT activity and the results suggest that DA and cocaine both interact with Arg residues.	Arginine	6-9	solute carrier family 6 member 3	Rattus norvegicus	37-40
15103693-7	2004	Thus, Arg residues are important for DAT activity and the results suggest that DA and cocaine both interact with Arg residues.	Arginine	113-116	solute carrier family 6 member 3	Rattus norvegicus	37-40
15103693-10	2004	DA and cocaine may interact with the same functionally important Arg residue at the DAT, and 2).	Arginine	65-68	solute carrier family 6 member 3	Rattus norvegicus	84-87
15103693-11	2004	some members of the tropane and 1,4-dialkylpiperazine classes of DAT inhibitors may interact differently with DAT-derived Arg residue(s) furthers the notion that DAT activity sparing antagonists of cocaine can be designed.	Arginine	122-125	solute carrier family 6 member 3	Rattus norvegicus	65-68
15103693-11	2004	some members of the tropane and 1,4-dialkylpiperazine classes of DAT inhibitors may interact differently with DAT-derived Arg residue(s) furthers the notion that DAT activity sparing antagonists of cocaine can be designed.	Arginine	122-125	solute carrier family 6 member 3	Rattus norvegicus	110-113
15103693-11	2004	some members of the tropane and 1,4-dialkylpiperazine classes of DAT inhibitors may interact differently with DAT-derived Arg residue(s) furthers the notion that DAT activity sparing antagonists of cocaine can be designed.	Arginine	122-125	solute carrier family 6 member 3	Rattus norvegicus	110-113
15158149-8	2004	Administration of L-arginine 10 min before reperfusion markedly decreased TUNEL-positive staining cardiomyocytes, reduced myocardial caspase-3 activity, inhibited iNOS expression, and reduced myocardial nitrotyrosine content.	Arginine	18-28	caspase 3	Rattus norvegicus	133-142
15701790-1	2005	Btn2p, a novel cytosolic coiled-coil protein in Saccharomyces cerevisiae, was previously shown to interact with and to be necessary for the correct localization of Rhb1p, a regulator of arginine uptake, and Yif1p, a Golgi protein.	Arginine	186-194	Btn2p	Saccharomyces cerevisiae S288C	0-5
18077447-6	2008	From the crystal structures, we see that small conformational adjustments limited to several side chains enable mesotrypsin-BPTI complex formation, surmounting the predicted steric clash introduced by Arg-193.	Arginine	201-204	serine protease 3	Homo sapiens	112-123
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	145-148	serine protease 3	Homo sapiens	26-37
15161750-6	2004	Indeed, using low-temperature SDS-PAGE and real-time analysis of nNOS dimerization by surface plasmon resonance, we could show that 7-NI, which competes with arginine and tetrahydrobiopterin (BH(4)), an essential cofactor for nNOS dimer formation, inhibits dimerization of the enzyme, whereas the substrate-based inhibitor l-NAME stabilizes the homodimeric state of nNOS.	Arginine	158-166	nitric oxide synthase 1	Homo sapiens	65-69
15701790-6	2005	Btn1p was subsequently shown to be required for the optimal transport of arginine into the vacuole.	Arginine	73-81	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	0-5
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	145-148	serine protease 3	Homo sapiens	133-144
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	162-165	serine protease 3	Homo sapiens	26-37
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	162-165	serine protease 3	Homo sapiens	133-144
18081893-1	2008	FVIII is activated by cleavage at Arg(372), Arg(740), and Arg(1689) by thrombin.	Arginine	34-37	coagulation factor VIII	Homo sapiens	0-5
15175298-4	2004	Exogenous arginine repressed the specific activities of glutamate synthase (GltBD) and anabolic NADP-dependent GDH (GdhA) in cell extracts of strain PAO1, and this repression was abolished in an argR mutant.	Arginine	10-18	glutamate dehydrogenase	Pseudomonas aeruginosa PAO1	116-120
15624111-3	2005	The properties of GluR2 are generated posttranscriptionally by RNA editing at the Q/R site in the putative second membrane domain (M2), during which the glutamine (Q) codon is substituted by an arginine (R) codon.	Arginine	194-202	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	18-23
18081893-1	2008	FVIII is activated by cleavage at Arg(372), Arg(740), and Arg(1689) by thrombin.	Arginine	44-47	coagulation factor VIII	Homo sapiens	0-5
18081893-1	2008	FVIII is activated by cleavage at Arg(372), Arg(740), and Arg(1689) by thrombin.	Arginine	44-47	coagulation factor VIII	Homo sapiens	0-5
18081893-9	2008	These findings demonstrate that clustered basic residues within the 484-509 region of the A2 domain play a part of key role in thrombin-binding, which is responsible for thrombin-catalyzed FVIII activation by cleavage at Arg(372).	Arginine	221-224	coagulation factor VIII	Homo sapiens	189-194
18083889-4	2008	Nebivolol is a highly selective beta(1)-adrenergic receptor blocker that induces vasodilation through stimulation of the endothelial nitric oxide/L-arginine pathway.	Arginine	146-156	adrenoceptor beta 1	Homo sapiens	32-59
15642139-0	2005	Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies.	Arginine	79-87	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	20-24
15214434-1	2004	The influence of the two histidine and two arginine residues of mast cell degranulating peptide (MCD) in activity and binding was studied by replacing these amino acids in the MCD sequence with L-alanine.	Arginine	43-51	mucin 1, cell surface associated	Homo sapiens	64-95
15214434-1	2004	The influence of the two histidine and two arginine residues of mast cell degranulating peptide (MCD) in activity and binding was studied by replacing these amino acids in the MCD sequence with L-alanine.	Arginine	43-51	mucin 1, cell surface associated	Homo sapiens	97-100
15214434-7	2004	The analogs Ala8 (for His) and Ala16 (for Arg) showed the same binding affinities as MCD, whereas analog Ala7 (for Arg) and analog Ala13 (for His) showed slightly better binding affinity than the parent compound.	Arginine	42-45	mucin 1, cell surface associated	Homo sapiens	85-88
18173373-1	2008	Antibodies to citrullinated proteins (ACPA), i.e., to peptides posttranslationally modified by the conversion of arginine to citrulline, are specific serological markers for rheumatoid arthritis (RA).	Arginine	113-121	proteinase 3	Homo sapiens	38-42
15003833-5	2004	Mutagenesis of the amphibian residues Gln(76), Gly(81) and Val(83) to the human sequence (Arg(76)Asn(81)Gly(83)) generated a receptor mutant that bound astressin with even higher affinity than the native hCRF(1) receptor.	Arginine	90-93	corticotropin releasing hormone receptor 1	Homo sapiens	204-211
17962394-7	2008	A novel missense c.686C&gt;G mutation, which causes the substitution of a conserved arginine at amino acid position 229 by glycine (p.R229G) in exon 8 of the FRMD7 gene, was observed.	Arginine	84-92	FERM domain containing 7	Homo sapiens	158-163
15093672-3	2004	A functional polymorphism of the SULT1A1 gene has been implicated in a decreased activity and thermostability when the wild-type arginine (Arg) at codon 213 is substituted by a histidine (His).	Arginine	129-137	sulfotransferase family 1A member 1	Homo sapiens	33-40
15093672-3	2004	A functional polymorphism of the SULT1A1 gene has been implicated in a decreased activity and thermostability when the wild-type arginine (Arg) at codon 213 is substituted by a histidine (His).	Arginine	139-142	sulfotransferase family 1A member 1	Homo sapiens	33-40
18366047-4	2008	Galectin-3 formed two almost ideal arene-arginine stacking interactions according to computer modeling and also had the highest affinity for the diamido-thiodigalactosides (K(d) below 50 nM).	Arginine	41-49	galectin 3	Homo sapiens	0-10
14705965-7	2004	Amino acid analysis of the methylated arginine residues confirmed that both DART1 and DART4 catalyse the formation of asymmetrical dimethylated arginine residues and they are type I arginine methyltransferases.	Arginine	38-46	Arginine methyltransferase 1	Drosophila melanogaster	76-81
14705965-7	2004	Amino acid analysis of the methylated arginine residues confirmed that both DART1 and DART4 catalyse the formation of asymmetrical dimethylated arginine residues and they are type I arginine methyltransferases.	Arginine	144-152	Arginine methyltransferase 1	Drosophila melanogaster	76-81
18366047-5	2008	Site-directed mutagenesis of galectin-3 arginines involved in binding corroborated the importance of their interaction with the aromatic diamido-thiodigalactosides.	Arginine	40-49	galectin 3	Homo sapiens	29-39
14684599-8	2004	And 5) the N- and C-terminal P1 Arg residues, R11 and R54, respectively, were essential for mature GHRH production.	Arginine	32-35	growth hormone releasing hormone	Mus musculus	99-103
18552509-3	2008	METHODS: Glomerular arginine transport was measured by uptake of radiolabeled arginine ([(3)H]-L-arginine), cationic amino acid transporters (CAT)-1 and -2 and arginases I and II mRNA expression were determined using reverse transcription-polymerase chain reaction.	Arginine	20-28	solute carrier family 7 member 1	Rattus norvegicus	142-178
18552509-9	2008	CONCLUSIONS: BUO induces an increase in glomerular arginine transport via upregulation of CAT-1, probably due to increase in arginine utilization by a non-NO pathway.	Arginine	51-59	solute carrier family 7 member 1	Rattus norvegicus	90-95
18547979-8	2008	Deletion of an arginine at the N terminus of P17 abolished its ability to inhibit RGS4 GAP activity, as did deletions of C-terminal residues.	Arginine	15-23	regulator of G protein signaling 4	Homo sapiens	82-86
15016745-6	2004	Arginine and an NO donor activated focal adhesion kinase (a tyrosine kinase which localises to cell matrix contacts and mediates beta1 integrin signalling) after wounding.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	35-56
15016745-7	2004	Arginine stimulated cell migration was dependent on focal adhesion kinase (FAK) signalling, as demonstrated using adenovirus mediated transfection with a kinase negative mutant of FAK.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	52-73
15016745-7	2004	Arginine stimulated cell migration was dependent on focal adhesion kinase (FAK) signalling, as demonstrated using adenovirus mediated transfection with a kinase negative mutant of FAK.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	75-78
15016745-7	2004	Arginine stimulated cell migration was dependent on focal adhesion kinase (FAK) signalling, as demonstrated using adenovirus mediated transfection with a kinase negative mutant of FAK.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	180-183
15016745-10	2004	CONCLUSIONS: These results showed that L-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways.	Arginine	39-49	protein tyrosine kinase 2	Homo sapiens	91-94
15016745-10	2004	CONCLUSIONS: These results showed that L-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways.	Arginine	41-49	protein tyrosine kinase 2	Homo sapiens	91-94
18094424-0	2007	L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma.	Arginine	0-10	ornithine decarboxylase 1	Homo sapiens	42-65
14718525-0	2004	Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.	Arginine	25-33	TSC complex subunit 1	Mus musculus	0-4
18094424-8	2007	RESULTS: In patients with CRA, the proliferating cell nuclear antigen and survivin labeling indexes and ODC activity of the tumor and paratumor mucosa in the L-arginine-treated group after L-arginine treatment were significantly lower as compared with the corresponding pretreatment values (P &lt; 0.01).	Arginine	158-168	ornithine decarboxylase 1	Homo sapiens	104-107
15039704-6	2004	Structural analysis and mutagenesis show that binding of N-Aha1 promotes a conformational switch in the middle-segment catalytic loop (370-390) of Hsp90 that releases the catalytic Arg 380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone.	Arginine	181-184	activator of HSP90 ATPase activity 1	Homo sapiens	59-63
18094424-12	2007	This suggests that L-arginine can block the formation and development of colorectal tumors, and this effect might be related to the increased serum NO concentration and decreased ODC activity.	Arginine	19-29	ornithine decarboxylase 1	Homo sapiens	179-182
17764672-0	2007	Conserved lysin and arginin residues in the extracellular loop of P2X(3) receptors are involved in agonist binding.	Arginine	20-27	purinergic receptor P2X 3	Homo sapiens	66-72
14684736-3	2004	The cyclin L2 protein contains an N-terminal "cyclin box" and C-terminal dipeptide repeats of alternating arginines and serines, a hallmark of the SR family of splicing factors.	Arginine	106-115	cyclin L2	Homo sapiens	4-13
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Arginine	38-46	glycine amidinotransferase	Rattus norvegicus	75-79
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Arginine	38-46	guanidinoacetate N-methyltransferase	Rattus norvegicus	171-205
14769337-7	2004	As an example, the activity of neuronal nitric oxide synthase (nNOS), a NADPH-requiring enzyme, has been assessed by measuring the products NADP+ and l-citrulline at various substrate (l-arginine) concentrations.	Arginine	185-195	nitric oxide synthase 1	Homo sapiens	31-61
14769337-7	2004	As an example, the activity of neuronal nitric oxide synthase (nNOS), a NADPH-requiring enzyme, has been assessed by measuring the products NADP+ and l-citrulline at various substrate (l-arginine) concentrations.	Arginine	185-195	nitric oxide synthase 1	Homo sapiens	63-67
17928413-3	2007	This is a two-step process in which l-arginine:glycine amidinotransferase (AGAT) catalyzes the conversion of glycine and arginine to ornithine and guanidinoacetate (GAA); guanidinoacetate methyltransferase (GAMT) then catalyzes the S-adenosylmethionine-dependent methylation of GAA to creatine.	Arginine	38-46	guanidinoacetate N-methyltransferase	Rattus norvegicus	207-211
17928511-1	2007	Nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS).	Arginine	38-48	nitric oxide synthase, brain	Oryctolagus cuniculus	52-73
18028048-6	2007	The previously undescribed PAX9 mutation was observed in the paired box (exon 2); this was a heterozygote transition of C175 to T, implying the change of arginine 59 for a termination codon.	Arginine	154-162	paired box 9	Homo sapiens	27-31
15027030-8	2004	Here we report that peptide representing the Arg(255)-Ser(267) sequence of IgG1 is implicated in the binding to FcgammaRIIb.	Arginine	45-48	Fc gamma receptor IIb	Homo sapiens	112-123
14973076-8	2004	The combination of these two effects resulted in a 2.9-fold increase in the retention of radioactivity for Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)) relative to (125)I-IBA-NDP at 4 h. In vivo studies also showed that Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)) exhibited extremely high radioactivity accumulation and prolonged retention in the tumor.	Arginine	136-139	Norrie disease (pseudoglioma) (human)	Mus musculus	168-171
14973076-9	2004	Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)) and Ac-Lys((125)I-IBA)-ReCCMSH(Arg(11)) exhibited much higher tumor uptake at 24 h after injection compared with (125)I-IBA-NDP [7.18% injected dose/gram (ID/g), 4.92% ID/g, and 0.26% ID/g, respectively].	Arginine	69-72	Norrie disease (pseudoglioma) (human)	Mus musculus	162-165
14973076-10	2004	Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)) also showed very fast whole body clearance and low nonspecific radioactivity accumulation in normal tissues compared with (125)I-IBA-NDP and Ac-Lys((125)I-IBA)-ReCCMSH(Arg(11)).	Arginine	29-32	Norrie disease (pseudoglioma) (human)	Mus musculus	171-174
17988382-2	2007	In vivo assays revealed that in LOX-1 the basic spine arginine residues are important for binding, which is lost upon mutation of Trp150 with alanine.	Arginine	54-62	oxidized low density lipoprotein receptor 1	Homo sapiens	32-37
18039030-7	2007	In the prevalent mutational pathway I, arginine (AGA) was successively displaced by glycine (GGA) and glutamic acid (GAA).	Arginine	39-47	alpha glucosidase	Homo sapiens	117-120
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Arginine	74-77	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
15642139-8	2005	Using immobilized peptides, we confirmed that the dimethylated arginine residues play an essential role in the formation of major SmD1 and SmD3 autoepitopes.	Arginine	63-71	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	139-143
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Arginine	86-89	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
15642142-8	2005	Of four arginine residues in IS4VH CDR3 substituted to serines, two residues at positions 100 and 100 g had a major influence on the strength of CL binding while the two residues at positions 96 and 97 had no effect.	Arginine	8-16	CDR3	Homo sapiens	35-39
15642142-10	2005	In contrast, arginine residues in VL CDR2 or VL CDR3 did not enhance CL binding, and in one case may have contributed to inhibition of this binding.	Arginine	13-21	cerebellar degeneration related protein 2	Homo sapiens	37-41
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Arginine	86-89	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Arginine	86-89	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
18712106-4	2007	Furin is a very specific enzyme: it recognizes the cleavage-site sequence Arg-Xaa-Lys/Arg-Arg and catalyzes the hydrolysis of the precursors, containing a pair of basic amino acids Arg-Arg or Lys-Arg.	Arginine	86-89	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
17936706-4	2007	PP1 is targeted to SRp38 through direct interaction via its arginine/serine-rich (RS) domain.	Arginine	60-68	serine and arginine rich splicing factor 10	Homo sapiens	19-24
17681943-3	2007	We demonstrate that mutating six surface-exposed lysine residues to arginine (6KR) to interfere with ubiquitin attachment can stabilize CK2beta.	Arginine	68-76	casein kinase 2 beta	Homo sapiens	136-143
16358414-0	2005	Role of arginine residues 14 and 15 in dictating DNA binding stability and transactivation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator heterodimer.	Arginine	8-16	aryl hydrocarbon receptor	Homo sapiens	98-123
15635723-0	2005	Efficient synthesis and comparative studies of the arginine and Nomega,Nomega-dimethylarginine forms of the human nucleolin glycine/arginine rich domain.	Arginine	51-59	nucleolin	Homo sapiens	114-123
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	78-83
15581350-5	2004	Mutation of arginine 241 had marked effects on the hydroxylation of anionic substrates of CYP2C8 such as retinoic acid and fluvastatin.	Arginine	12-20	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	90-96
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	KH RNA binding domain containing, signal transduction associated 3	Homo sapiens	78-83
17917276-5	2007	The improved heat stability of Rb(1) brought about by the addition of L-arginine was thought to be closely related to its characteristics of interfering with nonenzymatic glycation and forming hydrogen bonds with Rb(1).	Arginine	70-80	RB transcriptional corepressor 1	Homo sapiens	31-36
15578946-1	2004	A family of three nitric oxide synthase 1(NOS) isoforms produces nitric oxide (NO*) and L-citrulline via a stepwise oxidation of the guanidinium nitrogen of L-arginine.	Arginine	157-167	nitric oxide synthase 1	Homo sapiens	18-41
17917276-5	2007	The improved heat stability of Rb(1) brought about by the addition of L-arginine was thought to be closely related to its characteristics of interfering with nonenzymatic glycation and forming hydrogen bonds with Rb(1).	Arginine	70-80	RB transcriptional corepressor 1	Homo sapiens	213-218
17875751-4	2007	These myeloid-derived suppressor cells (MDSC) reduce activated T-cell number and inhibit their function by multiple mechanisms, including depletion of l-arginine by arginase-1 (ARG1) production of nitric oxide, reactive oxygen species, and reactive nitrogen oxide species by inducible nitric oxide synthase.	Arginine	151-161	arginase 1	Homo sapiens	165-175
26443366-2	2004	The most significant advances of the last 10 to 15 years concern the arginine repressor, its structure and mode of action in both E. coli and Salmonella typhimurium, the sequence analysis of all arg structural genes in E. coli and Salmonella typhimurium, the resulting evolutionary inferences, and the dual regulation of the carAB operon.	Arginine	69-77	repressor	Escherichia coli	78-87
26443366-2	2004	The most significant advances of the last 10 to 15 years concern the arginine repressor, its structure and mode of action in both E. coli and Salmonella typhimurium, the sequence analysis of all arg structural genes in E. coli and Salmonella typhimurium, the resulting evolutionary inferences, and the dual regulation of the carAB operon.	Arginine	69-72	repressor	Escherichia coli	78-87
17613527-10	2007	A tight interaction between the N-region residue serine 339 of C-RAF and arginine 398 of the catalytic domain was identified and proposed to inhibit the kinase activity of RAF proteins, because abrogation of this interaction contributes to RAF activation.	Arginine	73-81	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	63-68
15492130-2	2004	In endothelial cells (ECs), L-arginine is the substrate for both NO synthase (NOS) and arginase.	Arginine	28-38	nitric oxide synthase 3	Sus scrofa	65-76
17613527-10	2007	A tight interaction between the N-region residue serine 339 of C-RAF and arginine 398 of the catalytic domain was identified and proposed to inhibit the kinase activity of RAF proteins, because abrogation of this interaction contributes to RAF activation.	Arginine	73-81	zinc fingers and homeoboxes 2	Homo sapiens	65-68
15229623-1	2004	Nitric oxide (NO) is formed from the conversion of L-arginine by nitric oxide synthase (NOS), which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS).	Arginine	51-61	nitric oxide synthase 1	Homo sapiens	65-86
15229623-1	2004	Nitric oxide (NO) is formed from the conversion of L-arginine by nitric oxide synthase (NOS), which exists in three isoforms: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS).	Arginine	51-61	nitric oxide synthase 1	Homo sapiens	136-140
17613527-10	2007	A tight interaction between the N-region residue serine 339 of C-RAF and arginine 398 of the catalytic domain was identified and proposed to inhibit the kinase activity of RAF proteins, because abrogation of this interaction contributes to RAF activation.	Arginine	73-81	zinc fingers and homeoboxes 2	Homo sapiens	172-175
17827728-0	2007	Mutations of arginine 222 in pre-transmembrane domain I of mouse 5-HT(3A) receptor abolish 20(R)- but not 20(S)-ginsenoside Rg(3) inhibition of 5-HT-mediated ion currents.	Arginine	13-21	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	65-72
18458453-2	2007	In this study, an acellular matrix of bovine pericardium (ABP) was chemically modified by the direct coupling of L-arginine after glutaraldehyde (GA) cross-linking.	Arginine	113-123	amine oxidase copper containing 1	Homo sapiens	58-61
15371428-8	2004	Like the ubiquitin fold ubiquitin regulatory X (UBX) domain in p47, the Npl4-UBD interacts with p97 via the loop between its strands 3 and 4 and a conserved arginine in strand 1.	Arginine	157-165	NPL4 homolog, ubiquitin recognition factor	Homo sapiens	72-76
15371428-8	2004	Like the ubiquitin fold ubiquitin regulatory X (UBX) domain in p47, the Npl4-UBD interacts with p97 via the loop between its strands 3 and 4 and a conserved arginine in strand 1.	Arginine	157-165	valosin containing protein	Homo sapiens	96-99
18458453-6	2007	Thermal and mechanical properties showed that the durability of L-arginine-treated matrices increased as compared with control ABP and GA-treated ABP.	Arginine	64-74	amine oxidase copper containing 1	Homo sapiens	127-130
18458453-8	2007	The in vivo calcification study demonstrated much less calcium deposition on L-arginine-treated ABP than GA-treated one.	Arginine	77-87	amine oxidase copper containing 1	Homo sapiens	96-99
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Arginine	154-157	matrix metallopeptidase 14	Homo sapiens	188-195
18458453-9	2007	In vitro cell viability results showed that ABP modified with L-arginine leads to a significant increase in attachment of human dermal fibroblasts.	Arginine	62-72	amine oxidase copper containing 1	Homo sapiens	44-47
18458453-10	2007	The obtained results attest to the usefulness of L-arginine-treated ABP matrices for cardiovascular bioprostheses.	Arginine	49-59	amine oxidase copper containing 1	Homo sapiens	68-71
17925066-4	2007	Results from these studies demonstrate that patients with the Arg/Arg phenotype at the 16th amino acid position of the beta2-adrenergic receptor may experience worsening asthma outcomes after regular beta2-agonist use.	Arginine	62-65	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	119-124
15371436-3	2004	The prototypic furin recognition cleavage site is Arg-X-Arg/Lys-Arg.	Arginine	50-53	furin, paired basic amino acid cleaving enzyme	Homo sapiens	15-20
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	0-3	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
17925066-4	2007	Results from these studies demonstrate that patients with the Arg/Arg phenotype at the 16th amino acid position of the beta2-adrenergic receptor may experience worsening asthma outcomes after regular beta2-agonist use.	Arginine	66-69	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	119-124
17427197-0	2007	D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium.	Arginine	25-35	SMAD family member 2	Homo sapiens	145-150
15328419-13	2004	A single arginine-to-serine mutation in light-chain CDR1 of B3 reduced binding to both those antigens and may also have reduced the pathogenicity of the expressed antibodies in severe combined immunodeficiency (SCID) mice.	Arginine	9-17	cerebellar degeneration related antigen 1	Mus musculus	52-56
17660250-8	2007	When the Arg mutation is added to the N-TIMP-1(AB2) mutant, it produces a gelatinase-specific inhibitor with Ki values of 2.8 and 0.4 nM for MMP-2 and -9, respectively.	Arginine	9-12	matrix metallopeptidase 2	Homo sapiens	141-153
15531073-2	2004	Trans-membrane l-arginine transportation mediated by the isozymes of cationic amino acid transporters (e.g. CAT-1, CAT-2, CAT-2A, and CAT-2B) is one crucial regulatory mechanism that regulates iNOS activity.	Arginine	15-25	solute carrier family 7 member 1	Rattus norvegicus	108-113
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	175-178	complement C4B (Chido blood group)	Homo sapiens	87-90
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	183-186	complement C4B (Chido blood group)	Homo sapiens	87-90
14623875-0	2004	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	Arginine	54-62	cyclin L2	Homo sapiens	20-29
14623875-0	2004	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	Arginine	54-62	cyclin L1	Homo sapiens	20-26
14623875-3	2004	Cyclin L2 contains an N-terminal cyclin domain and a C-terminal arginine/serine-rich domain (RS domain), which is a hallmark of many proteins involved in pre-mRNA processing.	Arginine	64-72	cyclin L2	Homo sapiens	0-9
14602725-1	2004	Neuronal nitric-oxide synthase (nNOS) is a constitutively expressed enzyme responsible for the production of nitric oxide (NO*) from l-arginine and O2.	Arginine	133-143	nitric oxide synthase 1	Homo sapiens	0-30
14602725-1	2004	Neuronal nitric-oxide synthase (nNOS) is a constitutively expressed enzyme responsible for the production of nitric oxide (NO*) from l-arginine and O2.	Arginine	133-143	nitric oxide synthase 1	Homo sapiens	32-36
14602725-6	2004	Spin trapping/EPR spectroscopy confirmed that stimulated nNOS-transfected cells grown in an l-arginine environment secreted NO* into the surrounding milieu.	Arginine	92-102	nitric oxide synthase 1	Homo sapiens	57-61
14602725-9	2004	Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media.	Arginine	78-88	nitric oxide synthase 1	Homo sapiens	14-18
14602725-9	2004	Inhibition of nNOS-generated NO* with the competitive NOS inhibitor, NG-nitro-l-arginine methyl ester, in cells grown in l-arginine restored ERK1/2 activation to levels similar to that found when nNOS was activated in l-arginine-free media.	Arginine	121-131	nitric oxide synthase 1	Homo sapiens	14-18
14602725-10	2004	These findings indicate that nNOS can differentially regulate the ERK signal transduction pathway in a manner dependent on the presence of l-arginine and the production of NO*.	Arginine	139-149	nitric oxide synthase 1	Homo sapiens	29-33
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	183-186	complement C4B (Chido blood group)	Homo sapiens	87-90
17597649-1	2007	A C-to-A nucleotide transversion (T1405N) in the gene that encodes carbamoyl-phosphate synthetase 1 (CPS1) has been correlated with low plasma concentrations of L-arginine in neonates.	Arginine	161-171	carbamoyl-phosphate synthase 1	Homo sapiens	67-99
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	185-189
15454438-9	2004	Additional point mutations identified a uniquely occurring arginine in the N-terminus of Cx46 as the main determinant for the change in voltage-dependent gating.	Arginine	59-67	gap junction protein alpha 3 L homeolog	Xenopus laevis	89-93
17597649-1	2007	A C-to-A nucleotide transversion (T1405N) in the gene that encodes carbamoyl-phosphate synthetase 1 (CPS1) has been correlated with low plasma concentrations of L-arginine in neonates.	Arginine	161-171	carbamoyl-phosphate synthase 1	Homo sapiens	101-105
17597649-2	2007	As plasma L-arginine concentrations are decreased in premature infants with necrotizing enterocolitis (NEC), we hypothesized that the CPS1 T1405N polymorphism would correlate with the presence of NEC.	Arginine	10-20	carbamoyl-phosphate synthase 1	Homo sapiens	134-138
15454439-4	2004	In the Kir3.1/Kir3.4 channel, mutation of an extracellular arginine residue, R155, in the Kir3.4 subunit markedly reduced K+ activation of the channel.	Arginine	59-67	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	7-13
17553804-8	2007	Although residues 499-505 directly precede the Arg-506 cleavage site for activated protein C (APC), the 499-505(VIII) FVa mutant was inactivated entirely normally by APC.	Arginine	47-50	APC regulator of WNT signaling pathway	Homo sapiens	94-97
15240005-5	2004	In addition, studies in fungi suggest that Rheb is involved in arginine uptake.	Arginine	63-71	Ras homolog, mTORC1 binding	Homo sapiens	43-47
14729963-4	2004	The N-terminal region containing the serine-rich (S) domain, the central RNA recognition motif (RRM), and the C-terminal arginine/serine/proline-rich (RS/P) domain of RNPS1 interact with p54, pinin, and hTra2 beta, respectively.	Arginine	121-129	RNA binding protein with serine rich domain 1	Homo sapiens	167-172
14729963-4	2004	The N-terminal region containing the serine-rich (S) domain, the central RNA recognition motif (RRM), and the C-terminal arginine/serine/proline-rich (RS/P) domain of RNPS1 interact with p54, pinin, and hTra2 beta, respectively.	Arginine	121-129	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	187-190
17456474-3	2007	Murine aortic endothelial (MAE) cells interact via alpha(v) integrins with the integrin-binding Arg-Gly-Asp OPN sequence and adhere to immobilized OPN.	Arginine	96-99	secreted phosphoprotein 1	Mus musculus	108-111
14597616-2	2004	We found that DNT was cleaved by furin, a mammalian endoprotease, on the C-terminal side of Arg(44), which generates an N-terminal fragment almost corresponding to the receptor-binding domain and a C-terminal remainder (deltaB) containing the enzymatic domain.	Arginine	92-95	furin, paired basic amino acid cleaving enzyme	Homo sapiens	33-38
17456474-3	2007	Murine aortic endothelial (MAE) cells interact via alpha(v) integrins with the integrin-binding Arg-Gly-Asp OPN sequence and adhere to immobilized OPN.	Arginine	96-99	secreted phosphoprotein 1	Mus musculus	147-150
15516781-9	2004	Mutation analysis revealed a novel homozygous point mutation in exon 7 of her AAAS gene, changing codon 194 encoding Arg (CGA) to a stop codon (TGA) (R194X).	Arginine	117-120	aladin WD repeat nucleoporin	Homo sapiens	78-82
15516781-14	2004	Mutation analysis revealed a homozygous point mutation in exon 4 of his AAAS gene, changing codon 119 encoding Arg (CGA) to a stop codon (TGA) (R119X).	Arginine	111-114	aladin WD repeat nucleoporin	Homo sapiens	72-76
17466295-8	2007	Methylation, detected by a monoclonal antibody specific for asymmetric, but not symmetric methyl residues, was observed as early as 1 h-2 h after stimulation and was sustained for up to 24 h. The anti-IgM-induced p36 arginine methylation was abrogated in the PRMT1-deficient cells, suggesting that PRMT1 induces p36 methylation.	Arginine	217-225	polyhomeotic 2	Mus musculus	213-216
14512271-1	2004	Previous work demonstrated that l-arginine, the substrate for nitric oxide (NO) synthase, is carried into inner medullary collecting duct (IMCD) cells via system y+, that the major system y+ gene product in IMCD is the cationic amino acid transporter 1 (CAT1), and that blockade of l-arginine uptake in the renal medulla decreases NO and leads to systemic hypertension.	Arginine	32-42	solute carrier family 7 member 1	Rattus norvegicus	219-252
14512271-1	2004	Previous work demonstrated that l-arginine, the substrate for nitric oxide (NO) synthase, is carried into inner medullary collecting duct (IMCD) cells via system y+, that the major system y+ gene product in IMCD is the cationic amino acid transporter 1 (CAT1), and that blockade of l-arginine uptake in the renal medulla decreases NO and leads to systemic hypertension.	Arginine	32-42	solute carrier family 7 member 1	Rattus norvegicus	254-258
14512271-6	2004	These results indicate that sodium loading leads to a decrease in immunoreactive CAT1 protein in the rat renal medulla, resulting in decreased l-arginine uptake capacity.	Arginine	143-153	solute carrier family 7 member 1	Rattus norvegicus	81-85
15187170-3	2004	The inhibitory action of 2AG and CP55,940 was reduced by the unselective nitric-oxide synthase (NOS) inhibitor N-monomethyl-L-arginine methylester (l-NAME) and reinstated by L-arginine, the physiological substrate.	Arginine	124-134	nitric oxide synthase, inducible	Cavia porcellus	73-94
15068667-6	2004	We observed that Lys-105 and Arg-109 are critical for IL13 binding to IL13Ralpha2, indeed.	Arginine	29-32	interleukin 13 receptor subunit alpha 2	Homo sapiens	70-81
17653038-9	2007	This mutation results in a substitution of proline for arginine in the helix termination motif that may disrupt the normal helix, leading to a dramatic structural change of the keratin 12 protein.	Arginine	55-63	keratin 12	Homo sapiens	177-187
14755131-0	2004	Arginine increases growth hormone gene expression in rat pituitary and GH3 cells.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	19-33
14755131-8	2004	The in vivo study demonstrated that Arg and OT infusion induced a 2.3-fold increase in GH mRNA expression, which could result from the Arg-mediated inhibition of somatostatin release.	Arginine	36-39	gonadotropin releasing hormone receptor	Rattus norvegicus	87-89
14755131-8	2004	The in vivo study demonstrated that Arg and OT infusion induced a 2.3-fold increase in GH mRNA expression, which could result from the Arg-mediated inhibition of somatostatin release.	Arginine	135-138	gonadotropin releasing hormone receptor	Rattus norvegicus	87-89
14755131-9	2004	In addition, in vitro Arg, but not OT, induced GH gene expression in hemipituitaries and GH3 cells, indicating that the aminoacid can act per se at the pituitary somatotrope level.	Arginine	22-25	gonadotropin releasing hormone receptor	Rattus norvegicus	47-49
14755131-10	2004	In conclusion, our data show for the first time that arginine stimulates GH gene expression in parallel to its recognized GH-releasing activity.	Arginine	53-61	gonadotropin releasing hormone receptor	Rattus norvegicus	73-75
14755131-10	2004	In conclusion, our data show for the first time that arginine stimulates GH gene expression in parallel to its recognized GH-releasing activity.	Arginine	53-61	gonadotropin releasing hormone receptor	Rattus norvegicus	122-124
15555906-4	2004	In the present study it was found that substitution of human CYP17 amino acids, Arg(347), Arg(358) and Arg(449), with non-cationic residues, yielded variants that were impaired in the two acyl-carbon bond cleavage activities, quantitatively to the same extent and these were reduced to between 3 and 4% of the wild-type protein.	Arginine	80-83	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	61-66
15555906-4	2004	In the present study it was found that substitution of human CYP17 amino acids, Arg(347), Arg(358) and Arg(449), with non-cationic residues, yielded variants that were impaired in the two acyl-carbon bond cleavage activities, quantitatively to the same extent and these were reduced to between 3 and 4% of the wild-type protein.	Arginine	90-93	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	61-66
15555906-4	2004	In the present study it was found that substitution of human CYP17 amino acids, Arg(347), Arg(358) and Arg(449), with non-cationic residues, yielded variants that were impaired in the two acyl-carbon bond cleavage activities, quantitatively to the same extent and these were reduced to between 3 and 4% of the wild-type protein.	Arginine	90-93	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	61-66
17459702-4	2007	The compounds obtained are the first non-arginine ligands of C3aR.	Arginine	41-49	complement C3a receptor 1	Homo sapiens	61-65
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	60-63	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	165-170
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	70-73	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	165-170
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	70-73	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	165-170
15543946-0	2004	Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction.	Arginine	53-61	Janus kinase 2	Homo sapiens	0-4
15543946-5	2004	Using molecular modeling algorithms of the Jak2 kinase domain, we identified a putative interaction between glutamic acid 1024 and an arginine at position 1113.	Arginine	134-142	Janus kinase 2	Homo sapiens	43-47
15176218-5	2004	In the same patients, receptor-negative tumors occurred more often (p = 0.032) than in combinations of higher level of 4-hydroxylase estradiol of S-allele in position 48 (Gly/Arg) of the CYP1B1 gene.	Arginine	175-178	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	187-193
17397797-0	2007	Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells.	Arginine	21-29	solute carrier family 7 member 2	Homo sapiens	45-49
14660799-0	2003	A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.	Arginine	19-27	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	48-53
14660799-5	2003	This arginine transport defect in btn1-delta is complemented by expression of either BTN1 or the human CLN3 gene and strongly suggests a function for transport of, or regulation of the transport of, basic amino acids into the vacuole or lysosome for yeast Btn1p, and human CLN3 protein, respectively.	Arginine	5-13	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	256-261
17397797-1	2007	In endothelial cells Tumor Necrosis Factor-alpha (TNFalpha) stimulates arginine transport through the increased expression of SLC7A2/CAT2 transcripts.	Arginine	71-79	solute carrier family 7 member 2	Homo sapiens	126-132
15377847-2	2004	A common arginine (R) to histidine (H) polymorphism at amino acid position 213 influences SULT1A1 activity and has been suggested as risk factor for a different types of cancers.	Arginine	9-17	sulfotransferase family 1A member 1	Homo sapiens	90-97
17397797-1	2007	In endothelial cells Tumor Necrosis Factor-alpha (TNFalpha) stimulates arginine transport through the increased expression of SLC7A2/CAT2 transcripts.	Arginine	71-79	solute carrier family 7 member 2	Homo sapiens	133-137
15028579-1	2003	Agmatine, an amine and organic cation, is formed by the decarboxylation of L-arginine by arginine decarboxylase.	Arginine	75-85	antizyme inhibitor 2	Mus musculus	89-111
17131038-3	2007	We performed a case-control study to test the association between two polymorphisms in the polbeta gene: a Pro --&gt; Arg change at codon 242 (the Pro242Arg polymorphism) and a Lys --&gt; Met change at codon 289 (the Lys289Met polymorphism) and breast cancer risk and cancer progression.	Arginine	118-121	DNA polymerase beta	Homo sapiens	91-98
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Arginine	130-138	Ras homolog, mTORC1 binding	Homo sapiens	64-68
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Arginine	130-138	RAS p21 protein activator 1	Homo sapiens	155-162
14634143-7	2003	These results indicate a role for V(H)CDR3 Arg residues in chromatin specificity of lupus-derived autoantibodies.	Arginine	43-46	CDR3	Homo sapiens	38-42
17513446-8	2007	Neonatal pigs, growing-finishing pigs, pregnant pigs, and adult rats tolerated large amounts of chronic supplemental arginine (e.g. 0.62, 0.32, 0.21, and 2.14 g.kg body weight-1.d-1, respectively) administered via enteral diets without the appearance of any adverse effect.	Arginine	117-125	Body weight QTL 17	Rattus norvegicus	169-177
14675208-2	2003	As NO is synthesized from L-arginine by NO synthases (NOS), the availability of L-arginine might be one rate-limiting factor of NO production at the wound site.	Arginine	26-36	nitric oxide synthase 1, neuronal	Mus musculus	40-52
14675208-2	2003	As NO is synthesized from L-arginine by NO synthases (NOS), the availability of L-arginine might be one rate-limiting factor of NO production at the wound site.	Arginine	80-90	nitric oxide synthase 1, neuronal	Mus musculus	40-52
15208323-9	2004	Therefore, despite having previously identified Arg-4, Pro-5, Leu-8, and Leu-10 in TI-JIP as independently critical for mediating JNK inhibition, we find their presence in other 11-mer peptides is not sufficient for JNK inhibition.	Arginine	48-51	SMAD family member 4	Homo sapiens	86-89
17513447-4	2007	In myeloid cells, arginine is mainly metabolized either by inducible nitric oxide (NO) synthases (iNOS) or by arginase 1, enzymes that are stimulated by T helper 1 or 2 cytokines, respectively.	Arginine	18-26	arginase 1	Homo sapiens	110-120
14602908-2	2003	Members of the SR protein family contain one or two N-terminal RNA binding domains, as well as a C-terminal arginine-serine (RS) rich domain.	Arginine	108-116	RNA binding protein with serine rich domain 1	Homo sapiens	15-25
14602908-7	2003	Truncation experiments with the RS domain of the human SR protein 9G8 identified a 29 amino acid segment, containing 26 arginine or serine residues, that is sufficient to activate splicing when fused to MS2.	Arginine	120-128	RNA binding protein with serine rich domain 1	Homo sapiens	55-65
17360743-4	2007	We map critical residues within an arginine-rich domain of HPV1 E1circumflexE4, and in a region known to facilitate E1circumflexE4 oligomerization, that are requisite for SRPK1 binding.	Arginine	35-43	SRSF protein kinase 1	Homo sapiens	171-176
12867416-0	2003	Arginine residues in the active site of human phenol sulfotransferase (SULT1A1).	Arginine	0-8	sulfotransferase family 1A member 1	Homo sapiens	71-78
12867416-4	2003	In this report, amino acid modification, computer structure modeling, and site-directed mutagenesis were used for studies of Arg residues in the active site of SULT1A1.	Arginine	125-128	sulfotransferase family 1A member 1	Homo sapiens	160-167
15315443-5	2004	The calculations also help to explain the absence of positively charged Lys/Arg side chains in the anion-binding sites of SBP and ModA.	Arginine	76-79	selenium binding protein 1	Homo sapiens	122-125
12867416-5	2003	The Arg-specific modification reagent, 2,3-butanedione, inactivated SULT1A1 in an efficient, time- and concentration-dependent manner, suggesting Arg residues play an important role in the catalytic activity of SULT1A1.	Arginine	4-7	sulfotransferase family 1A member 1	Homo sapiens	68-75
17427040-6	2007	We have generated mutated versions of the A. thaliana Shaggy-like kinase 3-2 (AtSK3-2), in which Lys(167) and Arg(178), respectively homologues to Lys(85) and Arg(96) of the mammal GSK3beta, were modified into Ala by site-directed mutagenesis.	Arginine	110-113	shaggy-like protein kinase 32	Arabidopsis thaliana	78-85
12867416-5	2003	The Arg-specific modification reagent, 2,3-butanedione, inactivated SULT1A1 in an efficient, time- and concentration-dependent manner, suggesting Arg residues play an important role in the catalytic activity of SULT1A1.	Arginine	4-7	sulfotransferase family 1A member 1	Homo sapiens	211-218
12867416-5	2003	The Arg-specific modification reagent, 2,3-butanedione, inactivated SULT1A1 in an efficient, time- and concentration-dependent manner, suggesting Arg residues play an important role in the catalytic activity of SULT1A1.	Arginine	146-149	sulfotransferase family 1A member 1	Homo sapiens	68-75
12867416-5	2003	The Arg-specific modification reagent, 2,3-butanedione, inactivated SULT1A1 in an efficient, time- and concentration-dependent manner, suggesting Arg residues play an important role in the catalytic activity of SULT1A1.	Arginine	146-149	sulfotransferase family 1A member 1	Homo sapiens	211-218
15282667-4	2004	The functional TAFI assay was based on the activation of plasma TAFI with thrombin-thrombomodulin, and the measure of TAFIa activity on the hippuryl-Arg substrate.	Arginine	149-152	carboxypeptidase B2	Homo sapiens	15-19
17427040-6	2007	We have generated mutated versions of the A. thaliana Shaggy-like kinase 3-2 (AtSK3-2), in which Lys(167) and Arg(178), respectively homologues to Lys(85) and Arg(96) of the mammal GSK3beta, were modified into Ala by site-directed mutagenesis.	Arginine	159-162	shaggy-like protein kinase 32	Arabidopsis thaliana	78-85
17341586-5	2007	In contrast, mutations of two residues in the C-terminal part of TM4 (Tyr(591) and Arg(594)) affected channel activation of TRPV4 by all stimuli, suggesting an involvement in channel gating rather than in interaction with agonists.	Arginine	83-86	transient receptor potential cation channel subfamily V member 4	Homo sapiens	124-129
15345968-2	2004	This study tested the hypothesis that L-arginine would increase regional CBF (rCBF) and brain tissue PO2 (PbtO2) at the injury site.	Arginine	38-48	CCAAT/enhancer binding protein zeta	Rattus norvegicus	73-76
15345968-2	2004	This study tested the hypothesis that L-arginine would increase regional CBF (rCBF) and brain tissue PO2 (PbtO2) at the injury site.	Arginine	38-48	CCAAT/enhancer binding protein zeta	Rattus norvegicus	78-82
15345968-6	2004	RESULTS: In animals who received L-arginine, the percentage rCBF from baseline (%CBF) was higher at the impact site after impact (p &lt; 0.001), during bilateral carotid occulation (BCO) (p = 0.001) and during reperfusion (p = 0.032).	Arginine	33-43	CCAAT/enhancer binding protein zeta	Rattus norvegicus	60-64
14527725-4	2003	The proteins encoded by these Fem1c genes share &gt;99% amino acid identity between human and mouse, 79% amino acid identity between mouse and zebrafish, and end with a C-terminal Arginine residue, which distinguishes them from other FEM-1 proteins reported thus far.	Arginine	180-188	fem-1 homolog C	Homo sapiens	30-35
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	37-45	cell division cycle 42	Homo sapiens	95-100
15345968-6	2004	RESULTS: In animals who received L-arginine, the percentage rCBF from baseline (%CBF) was higher at the impact site after impact (p &lt; 0.001), during bilateral carotid occulation (BCO) (p = 0.001) and during reperfusion (p = 0.032).	Arginine	33-43	CCAAT/enhancer binding protein zeta	Rattus norvegicus	61-64
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Arginine	118-121	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	129-132
15345968-8	2004	CONCLUSIONS: Administration of L-arginine increased rCBF in the injured brain tissue, and resulted in better preservation of CBF during BCO than D-arginine and saline.	Arginine	31-41	CCAAT/enhancer binding protein zeta	Rattus norvegicus	52-56
15345968-8	2004	CONCLUSIONS: Administration of L-arginine increased rCBF in the injured brain tissue, and resulted in better preservation of CBF during BCO than D-arginine and saline.	Arginine	31-41	CCAAT/enhancer binding protein zeta	Rattus norvegicus	53-56
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Arginine	175-178	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	218-222
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Arginine	207-210	NADH:ubiquinone oxidoreductase subunit B5	Homo sapiens	218-222
15161923-5	2004	Wild-type ADAMTS4 was co-localized with fibronectin as determined by confocal microscopy on the cell surface of stable 293T transfectants expressing ADAMTS4, although ADAMTS4 deletion mutants, including Delta Sp (Delta Arg(693)-Lys(837), lacking the spacer domain), showed negligible localization.	Arginine	219-222	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	10-17
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	37-45	cell division cycle 42	Homo sapiens	137-142
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	52-60	cell division cycle 42	Homo sapiens	95-100
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	52-60	cell division cycle 42	Homo sapiens	137-142
12950342-1	2003	Nitric oxide (NO) is a free radical synthesized from l-arginine by a family of NO synthase (NOS) enzymes, all of which are present in the skin, and also by reduction of sweat nitrate.	Arginine	53-63	nitric oxide synthase 1, neuronal	Mus musculus	79-90
12798351-2	2003	When compared with similar exposure to complete medium, deprivation of arginine, methionine or leucine gave rise to a time-dependent, slowly reversible increase in the cellular level of SSAT mRNA that started to be significant after 8, 12 or 16h and reached four-, five- and two-fold after 16h, respectively.	Arginine	71-79	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	186-190
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Arginine	118-121	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	133-136
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Arginine	118-121	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	249-252
12917322-6	2003	Conversion of lysine 36 to an unmethylatable arginine causes a decrease in the repression of GAL4 transcription, as does a Delta set2 mutation.	Arginine	45-53	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	93-97
17303572-5	2007	In this model the Switch 1 region acts as an allosteric activator that facilitates electrostatic interactions between Arg-196 in Kir/Gem and Asp-194, -270, and -272 in the nucleotide-kinase (NK) domain of Cavbeta3 and wedging Val-223 and His-225 of Kir/Gem into a hydrophobic pocket in the NK domain.	Arginine	118-121	GTP binding protein overexpressed in skeletal muscle	Homo sapiens	253-256
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	74-82	arginase 1	Homo sapiens	0-10
15148321-5	2004	Here, we have identified four basic amino acid residues (Lys-312, Lys-316, Lys-401, and Arg-409) in the basic surface of the Smad7 MH2 domain that play important roles in interaction with type I receptors.	Arginine	88-91	SMAD family member 7 L homeolog	Xenopus laevis	125-130
17119118-1	2007	Arginase 1 (ARG1) metabolizes arginine, thus reducing the availability of arginine as a substrate for nitric oxide synthase (NOS).	Arginine	74-82	arginase 1	Homo sapiens	12-16
17301828-1	2007	A nonsynonymous single nucleotide polymorphism (SNP) of the low-affinity IgE receptor (FcvarepsilonRII/CD23) gene resulting in an arginine to tryptophan exchange at amino-acid position 62 (R62W) has been associated with enhanced T-cell responses to antigen in allergic subjects.	Arginine	130-138	Fc epsilon receptor II	Homo sapiens	103-107
15196662-1	2004	In a case of familial early onset Alzheimer"s disease, a mutation was detected in exon 7 of the presenilin 1 gene at codon 226 with a resultant amino acid change from leucine (CTC) to arginine (CGC) (L226R).	Arginine	184-192	presenilin 1	Homo sapiens	96-108
12907314-6	2003	The nitric oxide synthase (NOS) substrate, L-arginine (60 mg/kg), inhibited the anticonvulsant property of agmatine and this effect was significantly reversed by NOS inhibitor N(G)-nitro-L-arginine (L-NAME, 30 mg/kg), implying an NO-dependent mechanism for L-arginine effect.	Arginine	43-53	nitric oxide synthase 1, neuronal	Mus musculus	4-25
12907314-6	2003	The nitric oxide synthase (NOS) substrate, L-arginine (60 mg/kg), inhibited the anticonvulsant property of agmatine and this effect was significantly reversed by NOS inhibitor N(G)-nitro-L-arginine (L-NAME, 30 mg/kg), implying an NO-dependent mechanism for L-arginine effect.	Arginine	187-197	nitric oxide synthase 1, neuronal	Mus musculus	4-25
17229696-2	2007	Previous studies demonstrated that the substitution of alanine for each of four arginine residues, which reside on the positively charged surface of UL42, resulted in decreased DNA binding affinity and a decreased ability to synthesize long-chain DNA by the polymerase.	Arginine	80-88	DNA polymerase processivity subunit	Human alphaherpesvirus 1	149-153
14623174-4	2003	Inhibition of NO and citrulline formation catalyzed by neuronal NOS in the presence of 7-MI appeared to be competitive versus both substrate L-arginine (L-arg) and (6R)-5,6,7,8-tetrahydrobiopterin (BH(4)) cofactor.	Arginine	141-151	nitric oxide synthase 1	Homo sapiens	55-67
14623174-4	2003	Inhibition of NO and citrulline formation catalyzed by neuronal NOS in the presence of 7-MI appeared to be competitive versus both substrate L-arginine (L-arg) and (6R)-5,6,7,8-tetrahydrobiopterin (BH(4)) cofactor.	Arginine	141-146	nitric oxide synthase 1	Homo sapiens	55-67
15004000-7	2004	treating cells cultured on fibronectin with soluble Arg-Gly-Asp-Ser (RGDS) peptide to specifically block integrin-fibronectin interactions.	Arginine	52-55	ral guanine nucleotide dissociation stimulator	Homo sapiens	69-73
17289216-5	2007	Gonadotropin-releasing activity of Arg(8)-GnRH-III was improved 3-11-fold.	Arginine	35-38	gonadotropin releasing hormone 1	Homo sapiens	42-46
15252770-3	2004	NO is synthesized from L-arginine by NO synthases (NOS).	Arginine	23-33	nitric oxide synthase 1, neuronal	Mus musculus	37-49
12733990-11	2003	The substrates Abz-KPRGSKQ-EDDnp and Abz-KKPGSKQ-EDDnp were cleaved by cathepsin K at the Arg-Gly and Gly-Ser bonds respectively, and have been shown to be specific for cathepsin K when compared with other lysosomal cysteine proteases such as cathepsins L and B and with the aspartyl protease cathepsin D.	Arginine	90-93	cathepsin D	Homo sapiens	293-304
17375198-3	2007	MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val(5) and Lys(79)-Arg(80).	Arginine	75-78	chemokine (C-X-C motif) ligand 5	Mus musculus	41-44
12876319-4	2003	Site-directed mutagenesis was utilized to construct amino acid substitutions in B. subtilis adenylosuccinate lyase; Met(10), Ile(123), and Thr(367) were replaced by Leu, Trp, and Arg, respectively, and the altered enzymes were expressed in Escherichia coli.	Arginine	179-182	adenylosuccinate lyase	Homo sapiens	92-114
15197279-9	2004	By changing each of the Arg residues to Ala, we demonstrated that only the Arg residues at positions 331 and 332 were required for binding nsP4 to the SG promoter.	Arginine	24-27	serine protease 57	Homo sapiens	139-143
15197279-9	2004	By changing each of the Arg residues to Ala, we demonstrated that only the Arg residues at positions 331 and 332 were required for binding nsP4 to the SG promoter.	Arginine	75-78	serine protease 57	Homo sapiens	139-143
12691605-9	2003	In conclusion, although the accepted furin processing motif is Arg-Xaa-(Lys/Arg)-Arg downward arrow, our data further extend it to include a regulatory histidine residue at P6 in precursors that lack a basic residue at P4.	Arginine	63-66	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Arginine	91-99	pancreatic polypeptide	Homo sapiens	194-196
12691605-9	2003	In conclusion, although the accepted furin processing motif is Arg-Xaa-(Lys/Arg)-Arg downward arrow, our data further extend it to include a regulatory histidine residue at P6 in precursors that lack a basic residue at P4.	Arginine	76-79	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
12691605-9	2003	In conclusion, although the accepted furin processing motif is Arg-Xaa-(Lys/Arg)-Arg downward arrow, our data further extend it to include a regulatory histidine residue at P6 in precursors that lack a basic residue at P4.	Arginine	76-79	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
12748290-6	2003	We also find that the Src family kinase Hck phosphorylates the Abl and Arg activation loops, leading to an additional twofold stimulation of kinase activity.	Arginine	71-74	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	40-43
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Arginine	80-83	insulin like growth factor binding protein 2	Homo sapiens	13-21
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Arginine	80-83	insulin like growth factor binding protein 2	Homo sapiens	14-21
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Arginine	154-157	insulin like growth factor binding protein 2	Homo sapiens	13-21
15171717-5	2004	Bound (125)I-hIGFBP-2 was reversibly displaced by IGFBP-2, IGFBP-1 and RGD-(Gly-Arg-Asp)-containing peptides, but not by IGFBP-3, -4, -5, -6 and RGE-(Gly-Arg-Glu)-containing peptides.	Arginine	154-157	insulin like growth factor binding protein 2	Homo sapiens	14-21
12810105-3	2003	MSCs use two enzymes involved in arginine metabolism to control T-cell responses: inducible nitric oxide synthase (NOS2), which generates nitric oxide (NO) and arginase 1 (Arg1), which depletes the milieu of arginine.	Arginine	33-41	arginase 1	Homo sapiens	160-170
12810105-3	2003	MSCs use two enzymes involved in arginine metabolism to control T-cell responses: inducible nitric oxide synthase (NOS2), which generates nitric oxide (NO) and arginase 1 (Arg1), which depletes the milieu of arginine.	Arginine	33-41	arginase 1	Homo sapiens	172-176
15214434-0	2004	Partial alanine scan of mast cell degranulating peptide (MCD): importance of the histidine- and arginine residues.	Arginine	96-104	mucin 1, cell surface associated	Homo sapiens	57-60
12810105-3	2003	MSCs use two enzymes involved in arginine metabolism to control T-cell responses: inducible nitric oxide synthase (NOS2), which generates nitric oxide (NO) and arginase 1 (Arg1), which depletes the milieu of arginine.	Arginine	208-216	arginase 1	Homo sapiens	172-176
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	73-81	pancreatic polypeptide	Homo sapiens	225-227
15029234-0	2004	Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves" disease.	Arginine	0-8	major histocompatibility complex, class II, DR alpha	Homo sapiens	31-43
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	143-146	pancreatic polypeptide	Homo sapiens	225-227
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	208-211	pancreatic polypeptide	Homo sapiens	225-227
17204471-7	2007	Furthermore, Arg(25) of PP and NPY is involved in ligand binding only at Y(2)R and Y(5)R. This suggests significant differences in the docking of YR ligands between Y(1/4)R and Y(2/5)R and provides new insights into the molecular binding mode of peptide agonists at GPCRs.	Arginine	13-16	pancreatic polypeptide	Homo sapiens	24-26
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Arginine	160-168	carboxypeptidase B1 (tissue)	Mus musculus	68-86
12606428-2	2003	NO is produced from l-arginine by the enzyme nitric oxide synthase (NOS), which has three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	20-30	nitric oxide synthase 1	Homo sapiens	45-66
17214959-3	2007	Substitution of first arginine residue with alanine in Tat basic domain (M-Tat) severely reduced cellular uptake of the peptide (3.8 times less than Tat).	Arginine	22-30	tyrosine aminotransferase	Homo sapiens	55-58
15090652-2	2004	By sequencing candidate genes in this region, we identified a mutation that causes replacement of an arginine with a tryptophan (R14W) in the signal sequence of the CA4 gene at position -5 relative to the signal sequence cleavage site.	Arginine	101-109	carbonic anhydrase 4	Homo sapiens	165-168
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Arginine	157-165	EWS RNA binding protein 1	Homo sapiens	28-31
15084284-4	2004	We provide evidence that the Rho inhibitor p190RhoGAP (GTPase-activating protein) is an Arg substrate in the postnatal mouse brain.	Arginine	88-91	Rho GTPase activating protein 35	Mus musculus	43-53
17214959-3	2007	Substitution of first arginine residue with alanine in Tat basic domain (M-Tat) severely reduced cellular uptake of the peptide (3.8 times less than Tat).	Arginine	22-30	tyrosine aminotransferase	Homo sapiens	75-78
15084284-5	2004	We show that p190RhoGAP has reduced phosphotyrosine content in postnatal arg(-/-) mouse brain extracts relative to wild-type extracts.	Arginine	73-76	Rho GTPase activating protein 35	Mus musculus	13-23
15084284-7	2004	Arg can phosphorylate p190RhoGAP in vitro and in vivo on tyrosine (Y) 1105.	Arginine	0-3	Rho GTPase activating protein 35	Mus musculus	22-32
15084284-8	2004	We find that Arg can stimulate p190RhoGAP to inhibit Rho and that Arg-mediated phosphorylation is required for this stimulation.	Arginine	13-16	Rho GTPase activating protein 35	Mus musculus	31-41
15084284-9	2004	Phosphorylation by Arg also promotes p190RhoGAP"s association with p120RasGAP and stimulates p190RhoGAP"s ability to induce neuritogenesis in neuroblastoma cells.	Arginine	19-22	Rho GTPase activating protein 35	Mus musculus	37-47
15084284-10	2004	Our results demonstrate that p190RhoGAP is an Arg substrate in the developing brain and suggest that Arg mediates the adhesion-dependent regulation of neuronal morphogenesis in the postnatal brain by phosphorylating p190RhoGAP.	Arginine	46-49	Rho GTPase activating protein 35	Mus musculus	29-39
15084284-10	2004	Our results demonstrate that p190RhoGAP is an Arg substrate in the developing brain and suggest that Arg mediates the adhesion-dependent regulation of neuronal morphogenesis in the postnatal brain by phosphorylating p190RhoGAP.	Arginine	101-104	Rho GTPase activating protein 35	Mus musculus	29-39
15084284-10	2004	Our results demonstrate that p190RhoGAP is an Arg substrate in the developing brain and suggest that Arg mediates the adhesion-dependent regulation of neuronal morphogenesis in the postnatal brain by phosphorylating p190RhoGAP.	Arginine	101-104	Rho GTPase activating protein 35	Mus musculus	216-226
15044109-5	2004	From comparison with the crystal structure of the bacterial homologue GlpF and the bovine erythrocyte water channel bAQP1, AQP9 residues Phe-64 and Arg-219 are predicted to serve as part of the selectivity filter.	Arginine	148-151	aquaporin 9	Bos taurus	123-127
15048779-4	2004	Two of those residues, Glu(3) and Arg(6), form an EXXR motif that was found to be common among library-derived IL-5 antagonists.	Arginine	34-37	interleukin 5	Homo sapiens	111-115
15048779-11	2004	The dominance of Arg(6) in AF17121 activity corresponds to previous findings of dominance of the positive charge balance in the antiparallel beta-sheet of IL-5 composed of (88)EERRR(92) in one strand of the CD turn region of IL-5 and with Arg(32) in the neighboring beta-strand.	Arginine	17-20	interleukin 5	Homo sapiens	155-159
15048779-11	2004	The dominance of Arg(6) in AF17121 activity corresponds to previous findings of dominance of the positive charge balance in the antiparallel beta-sheet of IL-5 composed of (88)EERRR(92) in one strand of the CD turn region of IL-5 and with Arg(32) in the neighboring beta-strand.	Arginine	239-242	interleukin 5	Homo sapiens	155-159
14871882-17	2004	Because OAT and AII proteins overlapped in PST mitochondria, L-arginine-derived ornithine may be preferentially converted to L-glutamate, as proven by ornithine oxidation.	Arginine	61-71	ornithine aminotransferase	Rattus norvegicus	8-11
15016745-0	2004	Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism.	Arginine	0-8	protein tyrosine kinase 2	Homo sapiens	56-77
15086470-0	2004	Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats.	Arginine	10-18	solute carrier family 7 member 1	Rattus norvegicus	49-82
15086470-10	2004	CONCLUSION: In a rat model of early diabetes, glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration.	Arginine	57-65	solute carrier family 7 member 1	Rattus norvegicus	107-112
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone like hormone	Homo sapiens	67-86
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	17-20	parathyroid hormone like hormone	Homo sapiens	88-93
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone like hormone	Homo sapiens	67-86
15035617-2	2004	A Glu(19) --&gt; Arg(19) substitution, based on the Arg(19) of the PTH-related protein (PTHrP), increases the binding affinity when incorporated into the N-terminus of PTH [i.e., PTH(1-20)] and has no effect when introduced into the C-terminus of PTH [i.e., PTH(15-31)].	Arginine	52-55	parathyroid hormone like hormone	Homo sapiens	88-93
15027881-1	2004	The structure-activity requirements of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH(2) 4 were investigated by varying the position, structure, and charge of the Arg residues.	Arginine	62-65	opioid related nociceptin receptor 1	Homo sapiens	43-47
14722087-1	2004	Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence.	Arginine	131-134	secreted phosphoprotein 1	Mus musculus	0-11
14722087-1	2004	Osteopontin (OPN) is a highly hydrophilic and negatively charged sialoprotein of approximately 298 amino acids that contains a Gly-Arg-Gly-Asp-Ser sequence.	Arginine	131-134	secreted phosphoprotein 1	Mus musculus	13-16
15037072-2	2004	Protein cleavage sites for the Ricinus CysEP were determined with fluorogenic peptides (Abz-Xaa-Arg-/-Gln-Gln-Tyr(NO2)-Asp).	Arginine	96-99	vignain	Ricinus communis	39-44
15003013-1	2004	In this study, specific interactions between immobilized RGDS (Arg-Gly-Asp-Ser) cell adhesion peptides and cell integrin receptors located on cell membranes are controlled in vitro using stimuli-responsive polymer surface chemistry.	Arginine	63-66	ral guanine nucleotide dissociation stimulator	Homo sapiens	57-61
14988458-9	2004	Dietary supplementation with 0.4% L-arginine also increased (P &lt; 0.05) plasma concentrations of insulin and growth hormone by 24-27% in piglets, compared with controls.	Arginine	34-44	insulin	Sus scrofa	99-106
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	phospholipase C gamma 2	Homo sapiens	80-90
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	phospholipase C gamma 2	Homo sapiens	111-120
14973076-6	2004	Cellular retention studies showed that the receptor-bound radioiodinated linear alpha-MSH analog NDP was released from the cells into the medium very quickly, whereas significant amounts of cell-associated radioactivity remained in the cells for Ac-Lys((125)I-3- or 4-iodobenzoate (IBA))-ReCCMSH(Arg(11)) and Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)).	Arginine	296-299	pro-opiomelanocortin-alpha	Mus musculus	80-89
14973076-6	2004	Cellular retention studies showed that the receptor-bound radioiodinated linear alpha-MSH analog NDP was released from the cells into the medium very quickly, whereas significant amounts of cell-associated radioactivity remained in the cells for Ac-Lys((125)I-3- or 4-iodobenzoate (IBA))-ReCCMSH(Arg(11)) and Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)).	Arginine	296-299	Norrie disease (pseudoglioma) (human)	Mus musculus	97-100
14973076-6	2004	Cellular retention studies showed that the receptor-bound radioiodinated linear alpha-MSH analog NDP was released from the cells into the medium very quickly, whereas significant amounts of cell-associated radioactivity remained in the cells for Ac-Lys((125)I-3- or 4-iodobenzoate (IBA))-ReCCMSH(Arg(11)) and Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)).	Arginine	338-341	pro-opiomelanocortin-alpha	Mus musculus	80-89
14973076-6	2004	Cellular retention studies showed that the receptor-bound radioiodinated linear alpha-MSH analog NDP was released from the cells into the medium very quickly, whereas significant amounts of cell-associated radioactivity remained in the cells for Ac-Lys((125)I-3- or 4-iodobenzoate (IBA))-ReCCMSH(Arg(11)) and Ac-D-Lys((125)I-IBA)-ReCCMSH(Arg(11)).	Arginine	338-341	Norrie disease (pseudoglioma) (human)	Mus musculus	97-100
14739935-6	2004	Structural analysis and mutagenesis show that binding of N-Aha1 promotes a conformational switch in the middle-segment catalytic loop (370-390) of Hsp90 that releases the catalytic Arg 380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone.	Arginine	181-184	activator of HSP90 ATPase activity 1	Homo sapiens	59-63
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Arginine	104-107	phospholipase C beta 1	Homo sapiens	14-20
14746454-3	2004	The bacterial PI-PLC has no sequence homology with known glucose-6-phosphatase enzymes, which need His, Arg, and negatively charged residues (Asp or Glu) at the active site.	Arginine	104-107	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	57-78
14698296-5	2004	The IBP structure shows a direct and a water-mediated electrostatic interaction between Glu and Arg side-chains from adjacent strands, but no intra-strand interactions.	Arginine	96-99	trafficking protein particle complex subunit 9	Homo sapiens	4-7
14698296-6	2004	The interactions between IBP Glu and Arg side-chains are disrupted upon integrin binding.	Arginine	37-40	trafficking protein particle complex subunit 9	Homo sapiens	25-28
14659757-5	2004	Here, we report the identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalytic function of PDI, ERp57, ERp72 and P5, specifically for reoxidation.	Arginine	50-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	151-179
14659757-5	2004	Here, we report the identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalytic function of PDI, ERp57, ERp72 and P5, specifically for reoxidation.	Arginine	50-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	181-184
14659757-5	2004	Here, we report the identification of a conserved arginine residue, located in the loop between beta5 and alpha4 of the catalytic domains of the human protein disulphide isomerase (PDI) family, which is critical for the catalytic function of PDI, ERp57, ERp72 and P5, specifically for reoxidation.	Arginine	50-58	prolyl 4-hydroxylase subunit beta	Homo sapiens	242-245
14659757-6	2004	An examination of the published NMR structure for the a domain of PDI combined with molecular dynamic studies suggest that the side-chain of this arginine residue moves into and out of the active-site locale and that this has a very marked effect on the pK(a) value of the active-site cysteine residues.	Arginine	146-154	prolyl 4-hydroxylase subunit beta	Homo sapiens	66-69
15095356-6	2004	These characteristic ions allowed the rapid identification of a symmetrically arginine-dimethylated peptide from myelin basic protein and a symmetrically arginine-dimethylated peptide from SmD3 co-immunoprecipitated with the methyltransferase-associated protein pICln, suggesting that this method may provide a rapid means to screen for and characterize dimethylarginine sites.	Arginine	154-162	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	189-193
14527946-7	2003	We tested this hypothesis by mutating two surface residues, Arg-129 and Arg-172, located in a hydrophobic patch adjacent to the active site entrance on beta-ketoacyl-ACP reductase (FabG).	Arginine	60-63	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	166-169
14527946-7	2003	We tested this hypothesis by mutating two surface residues, Arg-129 and Arg-172, located in a hydrophobic patch adjacent to the active site entrance on beta-ketoacyl-ACP reductase (FabG).	Arginine	60-63	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	181-185
14527946-7	2003	We tested this hypothesis by mutating two surface residues, Arg-129 and Arg-172, located in a hydrophobic patch adjacent to the active site entrance on beta-ketoacyl-ACP reductase (FabG).	Arginine	72-75	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	166-169
14527946-7	2003	We tested this hypothesis by mutating two surface residues, Arg-129 and Arg-172, located in a hydrophobic patch adjacent to the active site entrance on beta-ketoacyl-ACP reductase (FabG).	Arginine	72-75	hydroxysteroid 17-beta dehydrogenase 8	Homo sapiens	181-185
14527946-11	2003	These data confirm a role for the highly conserved electronegative/hydrophobic residues along ACP helix alpha2 in recognizing a constellation of Arg residues embedded in a hydrophobic patch on the surface of its partner enzymes, and reveal a role for the loop-2 region in the conformational change associated with ACP binding.	Arginine	145-148	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	94-97
14527946-11	2003	These data confirm a role for the highly conserved electronegative/hydrophobic residues along ACP helix alpha2 in recognizing a constellation of Arg residues embedded in a hydrophobic patch on the surface of its partner enzymes, and reveal a role for the loop-2 region in the conformational change associated with ACP binding.	Arginine	145-148	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	314-317
14643027-3	2003	The SULT1A1 gene possesses a G--&gt;A polymorphism that results in an Arg to His amino acid substitution, and the His(213) allele has been shown to have low activity and low thermal stability.	Arginine	70-73	sulfotransferase family 1A member 1	Homo sapiens	4-11
14504281-3	2003	We show that mutation of charged glutamate and arginine residues behind the selectivity filter in the Kir3.1/Kir3.4 K+ channel reduces or abolishes K+ selectivity, comparable with previously reported effects in the Kir2.1 K+ channel.	Arginine	47-55	potassium inwardly rectifying channel subfamily J member 3	Homo sapiens	102-108
15028566-1	2003	Agmatine is a novel endogenous guanido amine synthesized from arginine by arginine decarboxylase.	Arginine	62-70	antizyme inhibitor 2	Mus musculus	74-96
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	23-31	ornithine decarboxylase 1	Homo sapiens	114-137
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	23-31	ornithine decarboxylase 1	Homo sapiens	139-142
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	244-252	ornithine decarboxylase 1	Homo sapiens	114-137
15028568-3	2003	The temporal switch of arginine as a substrate for the inducible nitric oxide synthase (iNOS)/NO axis to arginase/ornithine decarboxylase (ODC)/polyamine axis is subject to regulation by inflammatory cytokines as well as interregulation by the arginine metabolites themselves.	Arginine	244-252	ornithine decarboxylase 1	Homo sapiens	139-142
14628104-5	2003	An arginine residue in the fifth transmembrane domain, which is critical for activation of the C5aR by C5a, is also conserved in rainbow trout C5aR.	Arginine	3-11	C5a anaphylatoxin chemotactic receptor 1	Oncorhynchus mykiss	95-99
14628104-5	2003	An arginine residue in the fifth transmembrane domain, which is critical for activation of the C5aR by C5a, is also conserved in rainbow trout C5aR.	Arginine	3-11	C5a anaphylatoxin chemotactic receptor 1	Oncorhynchus mykiss	143-147
12737940-0	2003	Molecular characterization of G6PD Insuli--a novel 989 CGC --&gt; CAC (330 Arg --&gt; His) mutation in the Indian population.	Arginine	75-78	solute carrier family 25 member 20	Homo sapiens	66-69
12787807-8	2003	These results suggest that, although adult-onset type II citrullinemia is caused by a deficiency of citrin, which plays key roles in carbohydrates, amino acids and even lipid metabolism, some other environmental or genetic factors are required for the onset of the disease, and from the authors" clinical experience, a carbohydrate-restricted (relatively high-protein) diet is advocated as a benefit to the patients, and that arginine granules are indispensable to this new dietary therapy.	Arginine	426-434	solute carrier family 25 member 13	Homo sapiens	100-106
12631354-8	2003	L-Arginine administration increased albuminuria, renal matrix accumulation, TGF-beta 1, fibronectin, PAI-1, blood L-arginine, L-citrulline, BUN and blood and urine NOx levels, while protein restriction reduced these parameters.	Arginine	0-10	transforming growth factor, beta 1	Mus musculus	76-86
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Arginine	266-269	serpin family F member 1	Homo sapiens	145-149
12641447-4	2003	By utilizing residue-specific chemical modification and site-directed mutagenesis techniques, we revealed that the acidic amino acid residues on PEDF (Asp(255), Asp(257), and Asp(299)) are critical to collagen binding, and three clustered basic amino acid residues (Arg(145), Lys(146), and Arg(148)) are necessary for heparin binding.	Arginine	290-293	serpin family F member 1	Homo sapiens	145-149
12514171-8	2003	Introduction of an arginine at this position in Kir1.1 channels rendered the N-terminal PIP(2) site functional largely increasing the PIP(2) affinity.	Arginine	19-27	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	48-54
12633747-6	2003	We demonstrated that Arg specifically and dose-dependently induces pancreatitis, activates NF-kappaB (only the 3 g/kg dose) and proinflammatory cytokine synthesis, and increases the expressions of HSP60 and HSP72 in the pancreas of rats.	Arginine	21-24	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	207-212
12649168-2	2003	In DR4 exon 4, a C--&gt;G polymorphism at amino acid 626 located immediately 3" to one of the main receptor ligand interface regions, results in a threonine--&gt;arginine change.	Arginine	162-170	TNF receptor superfamily member 10a	Homo sapiens	3-6
12725421-9	2003	Our findings are consistent with a prior report that the Arg/His polymorphism in SULT1A1 is associated with breast cancer risk.	Arginine	57-60	sulfotransferase family 1A member 1	Homo sapiens	81-88
12579557-4	2003	RGDS (Arg-Gly-Asp-Ser) peptide immobilization onto PE film resulted in almost the same differentiation activity as the collagen immobilized PE film.	Arginine	6-9	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	0-4
12631327-2	2003	The arg11 mutant requires arginine (Arg) supplementation because it fails to export sufficient ornithine from the mitochondrion to the cytosol where it is converted to arginine.	Arginine	26-34	Ort1p	Saccharomyces cerevisiae S288C	4-9
12631327-2	2003	The arg11 mutant requires arginine (Arg) supplementation because it fails to export sufficient ornithine from the mitochondrion to the cytosol where it is converted to arginine.	Arginine	36-39	Ort1p	Saccharomyces cerevisiae S288C	4-9
12590570-2	2003	Asn(276) of Bacillus subtilis adenylosuccinate lyase, a residue corresponding to the location of a human enzyme mutation, was replaced by Cys, Ser, Ala, Arg, and Glu.	Arginine	153-156	adenylosuccinate lyase	Homo sapiens	30-52
12554955-3	2003	The tails of these Sm proteins contain symmetrically dimethylated arginines that are recognized by the central SMN Tudor domain.	Arginine	66-75	survival of motor neuron 1, telomeric	Homo sapiens	111-114
15199491-2	2003	In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)), which predicts the replacement of Arg (506) with a Gln at one of the cleavage sites for APC in factor V. Factor V is a Janus-faced protein with dual functions, serving as an essential nonenzymatic cofactor in both pro- and anticoagulant pathways.	Arginine	162-165	APC regulator of WNT signaling pathway	Homo sapiens	15-18
15199491-2	2003	In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)), which predicts the replacement of Arg (506) with a Gln at one of the cleavage sites for APC in factor V. Factor V is a Janus-faced protein with dual functions, serving as an essential nonenzymatic cofactor in both pro- and anticoagulant pathways.	Arginine	162-165	APC regulator of WNT signaling pathway	Homo sapiens	216-219
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	33-36	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	78-81	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	78-81	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	78-81	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	78-81	interferon alpha 17	Homo sapiens	20-26
12490311-4	2003	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	Arginine	78-81	interferon alpha 17	Homo sapiens	20-26
12504905-2	2003	Consistent with the X-ray crystal structures of RARalpha and RARgamma, site-directed mutagenesis studies have demonstrated the importance of a conserved Arg residue (alphaArg(276), betaArg(269), and gammaArg(278)) for coordination with the carboxyl group of RA.	Arginine	153-156	retinoic acid receptor gamma	Homo sapiens	61-69
12504905-5	2003	Our results demonstrate that in RARbeta mutants that acquire either RARalpha or RARgamma ligand specificity the Arg(269) position responsible for coordination with the carboxyl group of retinoids continued to function like that of RARbeta.	Arginine	112-115	retinoic acid receptor gamma	Homo sapiens	80-88
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	320-323	retinoic acid receptor gamma	Homo sapiens	152-160
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	367-370	retinoic acid receptor gamma	Homo sapiens	152-160
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Arginine	179-182	ectodysplasin A	Homo sapiens	48-51
14690597-5	2003	By modeling ubiquitin into the NEDD8 binding site and performing mutational analysis, we identify a single conserved arginine in APPBP1-UBA3 that acts as a selectivity gate, preventing misactivation of ubiquitin by NEDD8"s E1.	Arginine	117-125	NEDD8 ubiquitin like modifier	Homo sapiens	31-36
14690597-5	2003	By modeling ubiquitin into the NEDD8 binding site and performing mutational analysis, we identify a single conserved arginine in APPBP1-UBA3 that acts as a selectivity gate, preventing misactivation of ubiquitin by NEDD8"s E1.	Arginine	117-125	ubiquitin like modifier activating enzyme 3	Homo sapiens	136-140
14690597-5	2003	By modeling ubiquitin into the NEDD8 binding site and performing mutational analysis, we identify a single conserved arginine in APPBP1-UBA3 that acts as a selectivity gate, preventing misactivation of ubiquitin by NEDD8"s E1.	Arginine	117-125	NEDD8 ubiquitin like modifier	Homo sapiens	215-220
17214959-3	2007	Substitution of first arginine residue with alanine in Tat basic domain (M-Tat) severely reduced cellular uptake of the peptide (3.8 times less than Tat).	Arginine	22-30	tyrosine aminotransferase	Homo sapiens	75-78
12954649-5	2003	In addition, Asp-634 within the Shank1 PDZ domain recognizes the positively charged Arg at -1 position and hydrogen bonds, and salt bridges between Arg-607 and the side chains of the ligand at -3 and -5 positions contribute further to the recognition of the peptide ligand.	Arginine	84-87	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	32-38
17264152-0	2007	hCAF1, a new regulator of PRMT1-dependent arginine methylation.	Arginine	42-50	chromatin assembly factor 1 subunit A	Homo sapiens	0-5
12954649-5	2003	In addition, Asp-634 within the Shank1 PDZ domain recognizes the positively charged Arg at -1 position and hydrogen bonds, and salt bridges between Arg-607 and the side chains of the ligand at -3 and -5 positions contribute further to the recognition of the peptide ligand.	Arginine	148-151	SH3 and multiple ankyrin repeat domains 1	Homo sapiens	32-38
14520706-4	2003	Also, the smokers carrying the His SULT1A1 allele associated with a low sulfation activity had a 2-fold excess risk compared to never smokers carrying Arg/Arg SULT1A1 common genotype (ORi= 2.55, 95%CI: 1.21-5.36).	Arginine	155-158	sulfotransferase family 1A member 1	Homo sapiens	159-166
12467633-2	2003	Further SAR studies resulted in the discovery of Penta-5-BrAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and Penta-5-Me(2)NAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) which are potent hMC4R agonists and are inactive in hMC1R, hMC3R and hMC5R agonist assays.	Arginine	74-77	melanocortin 3 receptor	Homo sapiens	222-227
14517403-3	2003	Here we report the identification of a new NP1 transcript (designated NRP1(Delta exon16)) that contains an arginine codon in place of exon 16-derived sequences at a locus between the c-domain and membrane spanning domain.	Arginine	107-115	neuropilin 1	Homo sapiens	43-46
14517403-3	2003	Here we report the identification of a new NP1 transcript (designated NRP1(Delta exon16)) that contains an arginine codon in place of exon 16-derived sequences at a locus between the c-domain and membrane spanning domain.	Arginine	107-115	neuropilin 1	Homo sapiens	70-74
17098364-6	2007	These compounds inhibited the L-citrulline formation of nNOS from L-arginine, and the inhibitory effects were abrogated by raising the concentration of calmodulin.	Arginine	66-76	calmodulin 1	Rattus norvegicus	152-162
12507775-5	2003	The results also show a substantial increase in NO production in cells overexpressing GH that could be blocked by N(G)-monomethyl-L-arginine (L-NMMA), an L-arginine analogue that competitively inhibits all three isoforms of nitric oxide synthase (NOS).	Arginine	130-140	nitric oxide synthase 1, neuronal	Mus musculus	224-245
12643213-2	2003	Human Fc gamma RIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracellular domain (histidine or arginine respectively) and differ substantially in their ability to bind human IgG2.	Arginine	162-170	Fc gamma receptor IIa	Homo sapiens	6-19
14601095-1	2003	BACKGROUND: A recent study revealed that single nucleotide polymorphism (SNP) at codon 388 (Gly or Arg) of fibroblast growth factor receptor 4 (FGFR4) was associated with prognosis in patients with carcinoma of the breast and colorectal carcinoma.	Arginine	99-102	fibroblast growth factor receptor 4	Homo sapiens	107-142
14601095-1	2003	BACKGROUND: A recent study revealed that single nucleotide polymorphism (SNP) at codon 388 (Gly or Arg) of fibroblast growth factor receptor 4 (FGFR4) was associated with prognosis in patients with carcinoma of the breast and colorectal carcinoma.	Arginine	99-102	fibroblast growth factor receptor 4	Homo sapiens	144-149
17084840-3	2007	The FGFR4 Arg(388) allele was found to be associated with a poor prognosis for positive node breast cancer, high-grade soft-tissue sarcoma, colon carcinoma, and head and neck squamous cell carcinoma (HNSCC).	Arginine	10-13	fibroblast growth factor receptor 4	Homo sapiens	4-9
12925531-4	2003	We tested the generality of this binding mode by analyzing the action of a series of COX inhibitors against site-directed mutants of COX-2 bearing changes in Arg-120, Tyr-355, Tyr-348, and Ser-530.	Arginine	158-161	cytochrome c oxidase II, mitochondrial	Mus musculus	133-138
17084840-4	2007	METHODS: We decided to verify the impact of the FGFR4 Arg(388) allele on survival as well as its association with histoclinical data in 75 cases of HNSCC.	Arginine	54-57	fibroblast growth factor receptor 4	Homo sapiens	48-53
12501191-3	2002	Substrate specificity often employs a dual recognition strategy in which the sequence flanking the phospho-acceptor site (Ser.Pro.X.Arg/Lys) is recognized by CDK2, while the cyclin A component of the complex contains a hydrophobic site that binds Arg/Lys.X.Leu ("RXL" or "KXL") substrate recruitment motifs.	Arginine	132-135	cyclin dependent kinase 2	Homo sapiens	158-162
12501193-3	2002	On the basis of the structural determinations of the Cdc42-Cdc42GAP complex, as well as the Ras-RasGAP complex, it has been proposed that an arginine residue provided by the GAP (called the "arginine finger") stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and is an important contributor to GAP-stimulated catalysis.	Arginine	141-149	cell division cycle 42	Homo sapiens	53-58
12501193-3	2002	On the basis of the structural determinations of the Cdc42-Cdc42GAP complex, as well as the Ras-RasGAP complex, it has been proposed that an arginine residue provided by the GAP (called the "arginine finger") stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and is an important contributor to GAP-stimulated catalysis.	Arginine	141-149	cell division cycle 42	Homo sapiens	59-64
14627517-6	2003	The ALT level, caspase-3 activity and apoptotic hepatocyte count in the Arg group were decreased significantly than those in the control and Arg+L groups (P&lt;0.01).	Arginine	72-75	caspase 3	Rattus norvegicus	15-24
17084840-5	2007	The FGFR4 Arg(388) allele was detected by PCR-RFLP and DNA sequencing.	Arginine	10-13	fibroblast growth factor receptor 4	Homo sapiens	4-9
12464361-3	2002	The sheep insulin-like peptide 3 (INSL3), a structural homologue of relaxin, also contains the n, n+4 arginines in the B-chain but they are displaced towards the carboxyl terminus by four residues (-X-X-X-X-Arg-X-X-Val-Arg-).	Arginine	207-210	insulin-like 3	Ovis aries	10-32
17084840-6	2007	RESULTS: The FGFR4 Arg(388) allele was detected in 42.5% of the tumors (37% heterozygous Gly/Arg and 5.5% homozygous Arg/Arg).	Arginine	19-22	fibroblast growth factor receptor 4	Homo sapiens	13-18
12464361-3	2002	The sheep insulin-like peptide 3 (INSL3), a structural homologue of relaxin, also contains the n, n+4 arginines in the B-chain but they are displaced towards the carboxyl terminus by four residues (-X-X-X-X-Arg-X-X-Val-Arg-).	Arginine	207-210	insulin-like 3	Ovis aries	34-39
17084840-6	2007	RESULTS: The FGFR4 Arg(388) allele was detected in 42.5% of the tumors (37% heterozygous Gly/Arg and 5.5% homozygous Arg/Arg).	Arginine	93-96	fibroblast growth factor receptor 4	Homo sapiens	13-18
12464361-3	2002	The sheep insulin-like peptide 3 (INSL3), a structural homologue of relaxin, also contains the n, n+4 arginines in the B-chain but they are displaced towards the carboxyl terminus by four residues (-X-X-X-X-Arg-X-X-Val-Arg-).	Arginine	219-222	insulin-like 3	Ovis aries	10-32
12464361-3	2002	The sheep insulin-like peptide 3 (INSL3), a structural homologue of relaxin, also contains the n, n+4 arginines in the B-chain but they are displaced towards the carboxyl terminus by four residues (-X-X-X-X-Arg-X-X-Val-Arg-).	Arginine	219-222	insulin-like 3	Ovis aries	34-39
17084840-6	2007	RESULTS: The FGFR4 Arg(388) allele was detected in 42.5% of the tumors (37% heterozygous Gly/Arg and 5.5% homozygous Arg/Arg).	Arginine	93-96	fibroblast growth factor receptor 4	Homo sapiens	13-18
12464361-7	2002	We also synthesized analogues of INSL3, with amino acid substitutions in the arginine-binding region.	Arginine	77-85	insulin-like 3	Ovis aries	33-38
14627517-7	2003	The caspase-3 activity and apoptotic hepatocyte count in the Arg group were slightly higher than those in the sham and Fmk groups, but there was no statistical significance.	Arginine	61-64	caspase 3	Rattus norvegicus	4-13
17244541-5	2007	Two proteins, APD-1 and APD-2, contain an arginine-rich motif RERR in short non-hydrophobic stretches near the N-terminal of mature proteins and in both proteins tryptophan is the C-terminal residue.	Arginine	42-50	apidermin 1	Apis mellifera	14-19
14627517-8	2003	CONCLUSIONS: L-arg could ameliorate liver I/R injury and the possible protective mechanism is inhibition of hepatocyte apoptosis via inhibition of caspase-3 activity by nitric oxide synthesis.	Arginine	13-18	caspase 3	Rattus norvegicus	147-156
14668357-2	2003	Recessive mutations in ras2 and cyr1, as well as elevated dosage of PDE2, allowed cox2::arg8m-G66S to support Arg prototrophy.	Arginine	110-113	Ras family GTPase RAS2	Saccharomyces cerevisiae S288C	23-27
12565793-0	2002	Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis.	Arginine	76-86	fibroblast growth factor 10	Rattus norvegicus	66-72
12565793-5	2002	In the present study, we attempted to immunohistochemically determine the localization of FGF-7 and FGF-10 in pancreatic tissues of an L-arginine-induced rat pancreatitis model.	Arginine	135-145	fibroblast growth factor 10	Rattus norvegicus	100-106
12565793-9	2002	In the pancreatic tissues of rats with L-arginine-induced pancreatitis, FGF-7 was localized in alpha cells, whereas FGF-10 was expressed in vascular smooth muscle cells (VSMCs).	Arginine	39-49	fibroblast growth factor 10	Rattus norvegicus	116-122
17244541-5	2007	Two proteins, APD-1 and APD-2, contain an arginine-rich motif RERR in short non-hydrophobic stretches near the N-terminal of mature proteins and in both proteins tryptophan is the C-terminal residue.	Arginine	42-50	apidermin 2	Apis mellifera	24-29
17085448-0	2007	Residues His-15 and Arg-17 of HPr participate differently in catabolite signal processing via CcpA.	Arginine	20-23	haptoglobin-related protein	Homo sapiens	30-33
12482029-5	2002	Conversion of E1046 to either arginine (E 1046R), alanine (E1046A), aspartic acid (E1046D) or glutamine (E1046Q) abolished Jak2 kinase activity as measured by autophosphorylation assays.	Arginine	30-38	Janus kinase 2	Homo sapiens	123-127
14507173-2	2003	An 11-residue beta-peptide (1), an all-beta homologue of the Arg-rich region Tat 47-57, binds TAR RNA with K(d) = 29 +/- 4 nM.	Arginine	61-64	tyrosine aminotransferase	Homo sapiens	77-80
17297203-10	2007	Both combination and polymorphism of Arg 16 will bring greater effect on the response to beta-2 agonist.	Arginine	37-40	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-95
12913056-2	2003	l-Arginine, the substrate for nitric oxide synthase (NOS), decreases NaCl absorption by THALs.	Arginine	0-10	nitric oxide synthase 1, neuronal	Mus musculus	30-51
12913056-6	2003	In THALs from eNOS-/- mice transduced with Ad-NKCC2eNOS, adding L-arginine increased DAF-2DA fluorescence, a measure of NO production, by 9.1+/-1.1% (P&lt;0.05; n=5), but not in THALs transduced with Ad-NKCC2GFP.	Arginine	64-74	CD55 molecule, decay accelerating factor for complement B	Mus musculus	85-90
12446172-3	2002	L-Arginine can be transported by several kinetically defined transport systems, although the majority of arginine uptake is mediated by transport system y(+), encoded by the Cat1-3 gene family.	Arginine	0-10	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	174-180
12446172-3	2002	L-Arginine can be transported by several kinetically defined transport systems, although the majority of arginine uptake is mediated by transport system y(+), encoded by the Cat1-3 gene family.	Arginine	105-113	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	174-180
17097793-9	2007	Further variants comprising DDDDK(156)SS, DDDDK(156)SD and DDDDK(156)RR showed that the minimal critical determinants for enhanced enterokinase cleavage are serine in the P1" position followed by a serine or a basic residue, lysine or arginine, in the P2" position.	Arginine	235-243	transmembrane protease, serine 15	Mus musculus	131-143
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	145-148	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	145-148	furin, paired basic amino acid cleaving enzyme	Homo sapiens	173-178
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	173-178
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	173-178
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	furin, paired basic amino acid cleaving enzyme	Homo sapiens	173-178
14564672-12	2003	The disposal of arginine via nonurea pathways was also increased (0.702 +/- 0.185 v 0.257 +/- 0.025 mumol/g dry weight(-1)/min(-1); P &lt;.05).	Arginine	16-24	Body weight QTL 17	Rattus norvegicus	112-121
12956948-4	2003	RESULTS: X-ray crystallographic analysis of the Cdc42-RhoGDI complex suggested that arginine 66 of Cdc42 is essential for its interaction with RhoGDI.	Arginine	84-92	cell division cycle 42	Homo sapiens	48-53
12956948-4	2003	RESULTS: X-ray crystallographic analysis of the Cdc42-RhoGDI complex suggested that arginine 66 of Cdc42 is essential for its interaction with RhoGDI.	Arginine	84-92	cell division cycle 42	Homo sapiens	99-104
17902185-11	2007	The role played by His18 in the modulation of the biophysical properties of this hIAPP region was assessed by synthesising and studying the R18HrIAPP17-29 peptide; the replacement of a single Arg with a His residue is not sufficient to induce either amyloidogenic propensity or membrane interaction in this region.	Arginine	192-195	islet amyloid polypeptide	Homo sapiens	81-86
14656046-2	2003	NO is synthesized from L-arginine by NO synthase occurring in three isoforms of (neuronal, nNOS; endothelial, eNOS; inducible, iNOS).	Arginine	23-33	nitric oxide synthase 1, neuronal	Mus musculus	91-95
12923240-11	2003	The main roles of AI are regulation of arginine concentration by degrading arginine and production of ornithine for polyamine biosynthesis, but AI may not be the principal enzyme for regulating glutamate biosynthesis in tissues and cells.	Arginine	39-47	arginase, liver	Mus musculus	18-20
17204700-2	2007	Previous studies showed that (64)Cu-DOTA-ReCCMSH(Arg(11)) (DOTA is 1,4,7,10-tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid), a cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH), has the potential for the detection of malignant melanoma using PET.	Arginine	49-52	pro-opiomelanocortin-alpha	Mus musculus	150-186
12915128-2	2003	Recently, we had shown that EWS protein is not only localized in the nucleus and cytosol, but also on the surface of T cells and that its RBD is extensively asymmetrically dimethylated on arginine residues.	Arginine	188-196	EWS RNA binding protein 1	Homo sapiens	28-31
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Arginine	64-67	dual specificity phosphatase 6	Homo sapiens	144-148
12754209-4	2003	Thus, the common docking (CD) site composed of Glu-79, Tyr-126, Arg-133, Asp-160, Tyr-314, Asp-316, and Asp-319 are important for high affinity MKP3 binding but not essential for ERK2-induced MKP3 activation.	Arginine	64-67	dual specificity phosphatase 6	Homo sapiens	192-196
12754209-5	2003	MKP3 activation requires residues Tyr-111, Thr-116, Leu-119, Lys-149, Arg-189, Trp-190, Glu-218, Arg-223, Lys-229, and His-230 in the ERK2 substrate-binding region, located distal to the common docking site.	Arginine	70-73	dual specificity phosphatase 6	Homo sapiens	0-4
17204700-2	2007	Previous studies showed that (64)Cu-DOTA-ReCCMSH(Arg(11)) (DOTA is 1,4,7,10-tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid), a cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH), has the potential for the detection of malignant melanoma using PET.	Arginine	49-52	pro-opiomelanocortin-alpha	Mus musculus	188-197
12754209-5	2003	MKP3 activation requires residues Tyr-111, Thr-116, Leu-119, Lys-149, Arg-189, Trp-190, Glu-218, Arg-223, Lys-229, and His-230 in the ERK2 substrate-binding region, located distal to the common docking site.	Arginine	97-100	dual specificity phosphatase 6	Homo sapiens	0-4
17204700-5	2007	The goal of this study was to conjugate CBTE2A to the alpha-MSH targeting ReCCMSH(Arg(11)) peptide for labeling to (64)Cu and to investigate whether the increased metal-chelate stability with CBTE2A would improve imaging quality.	Arginine	82-85	pro-opiomelanocortin-alpha	Mus musculus	54-63
17204701-3	2007	METHODS: [Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) [(Arg(11))CCMSH] and [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]Re(Arg(11))CCMSH [DOTA-Re(Arg(11))CCMSH] were labeled with (99m)Tc and (111)In.	Arginine	31-34	pro-opiomelanocortin-alpha	Mus musculus	39-48
12909333-5	2003	RESULTS: There was a statistically significant increase in endothelium-dependent relaxation to serotonin and to bradykinin with methyltetrahydropterin and with superoxide dismutase plus catalase (P&lt;0.05) but not with L-arginine compared to untreated coronary arteries from left ventricular hypertrophy animals.	Arginine	220-230	catalase	Sus scrofa	186-194
17204701-3	2007	METHODS: [Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) [(Arg(11))CCMSH] and [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]Re(Arg(11))CCMSH [DOTA-Re(Arg(11))CCMSH] were labeled with (99m)Tc and (111)In.	Arginine	57-60	pro-opiomelanocortin-alpha	Mus musculus	39-48
17204701-3	2007	METHODS: [Cys(3,4,10),d-Phe(7),Arg(11)]alpha-MSH(3-13) [(Arg(11))CCMSH] and [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]Re(Arg(11))CCMSH [DOTA-Re(Arg(11))CCMSH] were labeled with (99m)Tc and (111)In.	Arginine	57-60	pro-opiomelanocortin-alpha	Mus musculus	39-48
17101795-3	2007	Here, we found that myocardin"s activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation.	Arginine	187-195	small ubiquitin like modifier 1	Homo sapiens	66-72
17979108-9	2007	Sequencing revealed that the peptides were predominantly amino- and carboxy-terminal protein fragments displaying a specificity characteristic of the acidic proteases cathepsin D and E. Many of the identified peptides contained arginine and/or lysine, allowing determination of the incorporation rate of these amino acids.	Arginine	228-236	cathepsin D	Homo sapiens	167-178
17176087-6	2006	In addition, Arg-92 and Arg-141 in the alpha chain as well as Arg-40 and Arg-104 in the beta chain were modified, whereas two other arginine residues, that is, Arg-31 in the alpha chain and Arg-30 in the beta chain, were not modified.	Arginine	132-140	activity regulated cytoskeleton associated protein	Homo sapiens	160-166
17046815-6	2006	VGLUT2s with mutations in the transmembrane-located residues Arg(184), His(128), and Glu(191) showed a dramatic loss in l-glutamate transport activity, whereas Na(+)-dependent inorganic phosphate (P(i)) uptake remained comparable to that of the wild type.	Arginine	61-64	solute carrier family 17 member 6	Homo sapiens	0-6
17056590-11	2006	Thus, these results suggest that Gal-3 is translocated to the nucleus, in part, via the importin-alpha/beta route and that Arg(224) amino acid residue of human Gal-3 is essential for its active nuclear translocation and its molecular stability.	Arginine	123-126	galectin 3	Homo sapiens	160-165
17142758-6	2006	Three of these residues (Tyr(15), Phe(75), and Arg(181)) concentrate their binding energy on the CDR2 loop residue Ser(52a), a noncanonical residue insertion found only in Vbeta2 and Vbeta4 chains.	Arginine	47-50	cerebellar degeneration related protein 2	Homo sapiens	97-101
17210244-9	2006	The first three arginine residues (aa 4-6) of CENP-A appear essential for antibody recognition, as replacing these arginines with glycine residues reduced antibody binding to the expressed CENP-A protein by an average of 93.2% (range 80-100%).	Arginine	115-124	centromere protein A	Homo sapiens	46-52
17210244-9	2006	The first three arginine residues (aa 4-6) of CENP-A appear essential for antibody recognition, as replacing these arginines with glycine residues reduced antibody binding to the expressed CENP-A protein by an average of 93.2% (range 80-100%).	Arginine	115-124	centromere protein A	Homo sapiens	189-195
16950780-5	2006	In this study, we showed that mutation to arginines of the four corresponding sites in the C1b domain of PKCdelta abolished its high potency for phorbol 12,13-dibutyrate in vitro, with only marginal remaining activity for phorbol 12-myristate 13-acetate in vivo.	Arginine	42-51	protein kinase C delta	Homo sapiens	105-113
16916952-2	2006	New data for cattle (Bos taurus) indicates a gene encoding GnRH-II decapeptide possessing arginine (codon: CGG) rather than tryptophan (TGG) at position three in the mature peptide.	Arginine	90-98	GnRHII precursor-like protein	Bos taurus	59-66
17053781-0	2006	Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation.	Arginine	79-87	nuclear receptor interacting protein 1	Homo sapiens	15-47
17053781-1	2006	Receptor interacting protein 140 (RIP140), a ligand-dependent corepressor for nuclear receptors, can be modified by arginine methylation.	Arginine	116-124	nuclear receptor interacting protein 1	Homo sapiens	0-32
17053781-1	2006	Receptor interacting protein 140 (RIP140), a ligand-dependent corepressor for nuclear receptors, can be modified by arginine methylation.	Arginine	116-124	nuclear receptor interacting protein 1	Homo sapiens	34-40
17053781-5	2006	A constitutive negative (Arg/Ala) mutant of RIP140 was resistant to the effect of PRMT1, and a constitutive positive (Arg/Phe) mutation mimicked the effect of arginine methylation.	Arginine	25-28	nuclear receptor interacting protein 1	Homo sapiens	44-50
17053781-7	2006	This study uncovered a novel means to inactivate, or suppress, RIP140, and demonstrated protein arginine methylation as a critical type of modification for corepressor.	Arginine	96-104	nuclear receptor interacting protein 1	Homo sapiens	63-69
16941565-0	2006	Analysis of the CD2 and spliceosomal Sm B/B" polyproline-arginine motifs defined by a monoclonal antibody using a phage-displayed random peptide library.	Arginine	57-65	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	37-43
16899465-5	2006	We have demonstrated that Abl-dependent phosphorylation of WAVE2 is necessary for its activation in vivo, which is highlighted by the findings that RNA interference of WAVE2 expression in Abl/Arg-/- cells has no additive effect on the amount of membrane ruffling.	Arginine	192-195	WASP family member 2	Homo sapiens	59-64
16899465-5	2006	We have demonstrated that Abl-dependent phosphorylation of WAVE2 is necessary for its activation in vivo, which is highlighted by the findings that RNA interference of WAVE2 expression in Abl/Arg-/- cells has no additive effect on the amount of membrane ruffling.	Arginine	192-195	WASP family member 2	Homo sapiens	168-173
16721827-2	2006	This protein is closely related to the cyclin-dependent kinase (Cdks) family and contains an arginine/serine-rich (RS) domain.	Arginine	93-101	cyclin dependent kinase 13	Homo sapiens	64-68
12892880-4	2003	When Escherichia coli is transformed with a plasmid carrying HP0099 from strain 26695, the recombinants acquire chemotaxis to arginine, bicarbonate, and urea.	Arginine	126-134	methyl-accepting chemotaxis protein	Helicobacter pylori 26695	61-67
12892880-5	2003	In H. pylori 43504, the HP0099 gene is interrupted with a mini-IS605 insertion, which accounts for its inability to recognize arginine and bicarbonate as attractants.	Arginine	126-134	methyl-accepting chemotaxis protein	Helicobacter pylori 26695	24-30
12892880-6	2003	Together, these results argue that the H. pylori HP0099 gene encodes an MCP for arginine and bicarbonate.	Arginine	80-88	methyl-accepting chemotaxis protein	Helicobacter pylori 26695	49-55
12736260-5	2003	An arginine residue in domain II, which in EF-G forms a salt bridge with a residue of the G domain, when mutated in Snu114p (R487E), led to a temperature-sensitive phenotype.	Arginine	3-11	U5 snRNP GTPase SNU114	Saccharomyces cerevisiae S288C	116-123
12740389-9	2003	Replacement of lysines 159 and 113 by arginines or increased sumoylation enhanced the stability of Smad4, and transcription in mammalian cells and Xenopus embryos.	Arginine	38-47	SMAD family member 4	Homo sapiens	99-104
12819663-6	2003	The avid binding of AID to ssDNA could result from its large net positive charge (+11) at pH 7.0, owing to a basic amino-terminal domain enriched in arginine and lysine.	Arginine	149-157	activation induced cytidine deaminase	Homo sapiens	20-23
12851615-3	2003	Recently, a common polymorphism has been identified at amino acid position 389 (Arg or Gly) of the human ADRB1, within a region important for receptor-Gs protein coupling and subsequent agonist-stimulated adenylyl cyclase activation.	Arginine	80-83	adrenoceptor beta 1	Homo sapiens	105-110
12734690-1	2003	We evaluated an autoradiographic (ARG) method to calculate regional cerebral blood flow (rCBF) sequentially before and after an acetazolamide (ACZ) challenge in a single session of single-photon emission tomography (SPET) with two injections of N-isopropyl-[(123)I] p-iodoamphetamine (IMP).	Arginine	34-37	CCAAT/enhancer binding protein zeta	Rattus norvegicus	89-93
12734690-14	2003	The dual-table ARG method can be reliably used to quantify rCBF before and after an ACZ challenge with a 40-min scan protocol and continuous arterial blood sampling for several minutes.	Arginine	15-18	CCAAT/enhancer binding protein zeta	Rattus norvegicus	59-63
12794637-3	2003	Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs.	Arginine	73-76	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12794637-3	2003	Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs.	Arginine	85-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12794637-3	2003	Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs.	Arginine	85-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
12794637-5	2003	Contoured surface loops shape the active site by cleft, thus explaining furin"s stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets.	Arginine	106-114	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
12761894-4	2003	NO is generated from L-arginine by the enzyme nitric oxide synthase (NOS).	Arginine	21-31	nitric oxide synthase 1, neuronal	Mus musculus	46-67
12813015-1	2003	Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.	Arginine	221-229	arginase, liver	Mus musculus	117-127
12704728-3	2003	NO is produced from l-arginine by the enzyme, nitric oxide synthase (NOS), which has three isoforms: endothelial (NOS3), neural (NOS1), and inducible (NOS2).	Arginine	20-30	nitric oxide synthase 1, neuronal	Mus musculus	46-67
12704728-3	2003	NO is produced from l-arginine by the enzyme, nitric oxide synthase (NOS), which has three isoforms: endothelial (NOS3), neural (NOS1), and inducible (NOS2).	Arginine	20-30	nitric oxide synthase 1, neuronal	Mus musculus	129-133
12756332-12	2003	In contrast, arginine methylation is required for the export of the nuclear RNA-binding proteins Npl3p, Hrp1p, and Nab2p.	Arginine	13-21	mRNA-binding protein NAB2	Saccharomyces cerevisiae S288C	115-120
12726922-7	2003	Additionally, the L-citrulline formation from L-arginine, which is the marker for NO synthesis, was stimulated by the treatment with H(2)O(2), and the H(2)O(2)-induced L-citrulline formation was strongly attenuated by NOS or GTPCH inhibitor.	Arginine	46-56	GTP cyclohydrolase 1	Homo sapiens	225-230
12578561-3	2003	Serine and arginine are also the residues at positions P"(1) and P"(2) in human kininogen, from which hK1 releases Lys-bradykinin.	Arginine	11-19	keratin 1	Homo sapiens	102-105
12924232-1	2003	The L-arginine--NO system functioning in rabbits with hepatic ischemia and reperfusion was modified by infusing the NO synthase (NOS) inhibitor NG-nitro-L-arginine (15 mg/kg) or the NOS substrate L-arginine (300 mg/kg).	Arginine	4-14	nitric oxide synthase, brain	Oryctolagus cuniculus	116-127
12924232-1	2003	The L-arginine--NO system functioning in rabbits with hepatic ischemia and reperfusion was modified by infusing the NO synthase (NOS) inhibitor NG-nitro-L-arginine (15 mg/kg) or the NOS substrate L-arginine (300 mg/kg).	Arginine	153-163	nitric oxide synthase, brain	Oryctolagus cuniculus	116-127
12787807-0	2003	Effectiveness of carbohydrate-restricted diet and arginine granules therapy for adult-onset type II citrullinemia: a case report of siblings showing homozygous SLC25A13 mutation with and without the disease.	Arginine	50-58	solute carrier family 25 member 13	Homo sapiens	160-168
12792224-8	2003	The authors suggest that additional studies to assess the role of the competing biochemical pathway, namely the conversion of l-arginine to polyamines via the actions of arginase and ornithine decarboxylase, may provide important new insights into understanding the regulation of mucosal inflammation and inflammatory bowel disease.	Arginine	126-136	ornithine decarboxylase 1	Homo sapiens	183-206
12578822-4	2003	A striking feature of the C/EBPalpha protein-DNA interface that distinguishes it from known bZIP-DNA complexes is the central role of Arg(289), which is hydrogen-bonded to base A(3), phosphate, Asn(292) (invariant in bZIPs), and Asn(293).	Arginine	134-137	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	26-36
12519080-11	2003	The last two arginine (R) residues of this sequence are required for activity, since their replacement by alanine completely abrogated the HBP/III5 cytoskeletal effect.	Arginine	13-21	heme binding protein 1	Homo sapiens	139-147
12562776-2	2003	Substitution of Arg(440) in IL5 with other residues except positively charged Lys caused a large shift in pH(i) dependence of (22)Na(+) uptake to an acidic side, whereas substitution of Gly(455) or Gly(456) within the highly conserved glycine-rich sequence of TM11 shifted pH(i) dependence to an alkaline side.	Arginine	16-19	interleukin 5	Homo sapiens	28-31
12562776-7	2003	Thus, both Arg(440) in IL5 and Gly residues in the conserved segment of TM11 appear to constitute important elements for proper functioning of the putative "pH(i) sensor" of Na(+)/H(+) exchanger 1.	Arginine	11-14	interleukin 5	Homo sapiens	23-26
12697734-1	2003	Mice with 50% Pdx1, a homeobox gene critical for pancreatic development, had worsening glucose tolerance with age and reduced insulin release in response to glucose, KCl, and arginine from the perfused pancreas.	Arginine	175-183	pancreatic and duodenal homeobox 1	Mus musculus	14-18
12422153-2	2002	There are 2 common polymorphisms of the beta1AR gene that alter the encoded amino acids at positions 49 (Ser or Gly) and 389 (Gly or Arg) and alter receptor function in vitro.	Arginine	133-136	adrenoceptor beta 1	Homo sapiens	40-47
12417033-6	2002	Among these putative protein methylacceptors, three are heterogeneous nuclear ribonucleoproteins (hnRNPA2/B1 and hnRNP K) that are reportedly methylated in their arginine- and glycine-rich RGG motifs.	Arginine	162-170	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	113-120
12363465-6	2002	In the MDS group, we found one patient with a conserved mutation (Lys--&gt;Arg) in the forked head-associated (FHA) domain of the CHK2 coding sequence.	Arginine	75-78	checkpoint kinase 2	Homo sapiens	130-134
12371970-3	2002	l-Arginine (l-Arg), the only precursor for NO, is transported into cells by cationic amino acid transporters, CAT-1 and CAT-2.	Arginine	0-10	solute carrier family 7 member 1	Rattus norvegicus	110-115
12371970-3	2002	l-Arginine (l-Arg), the only precursor for NO, is transported into cells by cationic amino acid transporters, CAT-1 and CAT-2.	Arginine	0-5	solute carrier family 7 member 1	Rattus norvegicus	110-115
12698555-6	2002	Recent study demonstrates the ability of enteropeptidase to hydrolyze peptide bonds formed by carboxyl groups of Lys or Arg residues if less than four but at least one negative charged amino acid residue is in any of substrate P2-P5 positions.	Arginine	120-123	transmembrane serine protease 15	Homo sapiens	41-56
12450325-3	2002	The result of Ala-scanning indicated that the N-terminal tripeptide RYY(= Arg-Tyr-Tyr) is crucially important for binding to the ORL1 receptor.	Arginine	74-77	opioid related nociceptin receptor 1	Homo sapiens	129-133
12242308-5	2002	We tested predictions deduced from these models by mutagenesis studies and found evidence for novel direct interactions between the E47 helix-loop-helix domain (Arg 357 or Asp 358) and the Pip N terminus (Leu 24).	Arginine	161-164	transcription factor 3	Homo sapiens	132-135
12234930-5	2002	b(o,+)AT-reconstituted systems from HeLa or MDCK cells catalysed transport of arginine that was totally dependent on the presence of one of the b(o,+) substrates inside the liposomes.	Arginine	78-86	ornithine aminotransferase	Homo sapiens	0-8
12234930-9	2002	Expressing the cystinuria-specific mutant A354T of b(o,+)AT in HeLa cells together with rBAT resulted in defective arginine uptake in whole cells, which was paralleled by the reconstituted b(o,+)AT activity.	Arginine	115-123	ornithine aminotransferase	Homo sapiens	51-59
12071861-5	2002	The 40 extra residues in rAFAR2 are located at the N-terminus of the polypeptide as an Arg-rich domain that may form an amphipathic alpha-helical structure.	Arginine	87-90	aldo-keto reductase family 7, member A2	Rattus norvegicus	25-31
12165803-6	2002	In BMP2 gene, AGA right curved arrow AGT transversion in exon 3, converting arginine to serine was detected.	Arginine	76-84	bone morphogenetic protein 2	Homo sapiens	3-7
12042306-9	2002	These residues are part of a motif found in Ntg2p (Arg(23)-Ser(24)-Lys(25)-Tyr(26)-Phe(27)), Exo1p (Arg(444)-Ser(445)-Lys(446)-Phe(447)-Phe(448)), and Sgs1p (Lys(1383)-Ser(1384)-Lys(1385)-Phe(1386)-Phe(1387)).	Arginine	51-54	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	44-49
12042323-0	2002	Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.	Arginine	115-118	glutamyl aminopeptidase	Homo sapiens	139-155
12107075-2	2002	After expression in Xenopus oocytes, alpha-ENaC constructs in which positively charged arginine residues were converted into negatively charged glutamic acids could not be inhibited by blocking peptides.	Arginine	87-95	sodium channel, non voltage gated 1 alpha subunit L homeolog	Xenopus laevis	37-47
11991804-6	2002	Evidence indicating that Arg-107 is essential for the 1-chloro-2,4-dinitrobenzene conjugation capacity of XlGSTM1-1 is also presented.	Arginine	25-28	glutathione S-transferase mu 1 S homeolog	Xenopus laevis	106-115
12128066-7	2002	cGMP production induced by methacholine, A23187 and thapsigargin was clearly inhibited by NG-nitro-L-arginine methylester (L-NAME), a specific inhibitor of nitric oxide synthase (NOS).	Arginine	101-109	nitric oxide synthase, brain	Oryctolagus cuniculus	156-177
12456008-0	2002	Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae.	Arginine	88-96	Btn2p	Saccharomyces cerevisiae S288C	17-22
12456008-0	2002	Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae.	Arginine	88-96	Btn2p	Saccharomyces cerevisiae S288C	62-67
12456008-6	2002	btn2delta strains, like rsg1delta strains, are sensitive for growth in the presence of the arginine analog canavanine.	Arginine	91-99	Btn2p	Saccharomyces cerevisiae S288C	0-4
12456008-8	2002	Overexpression of BTN2 results in a decreased rate of arginine uptake.	Arginine	54-62	Btn2p	Saccharomyces cerevisiae S288C	18-22
12456008-9	2002	Collectively, these results indicate that altered levels of Btn2p can modulate arginine uptake through localization of the Can1p-arginine permease regulatory protein, Rsglp.	Arginine	79-87	Btn2p	Saccharomyces cerevisiae S288C	60-65
12456008-11	2002	Btnlp is a vacuolar/lysosomal membrane protein, and btn1delta suppresses both the canavanine sensitivity and the elevated rate of uptake of arginine displayed by btn2delta rsg1delta strains.	Arginine	140-148	Btn2p	Saccharomyces cerevisiae S288C	162-166
12456008-12	2002	We conclude that Btn2p interacts with Rsglp and modulates arginine uptake.	Arginine	58-66	Btn2p	Saccharomyces cerevisiae S288C	17-22
12456008-13	2002	Up-regulation of BTN2 expression in btn1delta strains may facilitate either a direct or indirect effect on intracellular arginine levels.	Arginine	121-129	Btn2p	Saccharomyces cerevisiae S288C	17-21
12233810-3	2002	Since the mid-1990s, nitric oxide synthase (NOS), the enzyme that catalyzes the formation of nitric oxide (NO) from L-arginine, has received considerable attention as a potential candidate for cardiovascular gene therapy, because NO exerts critical and diverse functions in the cardiovascular system, and abnormalities in NO biology are apparent in a number of cardiovascular disease processes including cerebral vasospasm, atherosclerosis, postangioplasty restenosis, transplant vasculopathy, hypertension, diabetes mellitus, impotence and delayed wound healing.	Arginine	116-126	nitric oxide synthase 1	Homo sapiens	21-42
12428391-3	2002	In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group.	Arginine	7-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	169-175
11980906-2	2002	Cyclin L also contains a COOH-terminal dipeptide repeat of alternating arginines and serines, a hallmark of the SR family of splicing factors.	Arginine	71-80	cyclin L1	Homo sapiens	0-8
11994281-5	2002	Information transfer by agonist was controlled in residue 356 Galpha(11) mutants with rank order Tyr &gt; Phe &gt; Trp &gt; Ile &gt; Ala = Gln = Arg &gt; Ser &gt; Asp, although these alterations did not alter the binding affinity of either phenylephrine or an antagonist ligand.	Arginine	145-148	guanine nucleotide binding protein, alpha 11	Mus musculus	62-72
12095635-5	2002	These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition.	Arginine	88-91	serpin family D member 1	Homo sapiens	69-73
12363051-6	2002	Homozygotes for the arginine variant at position 131 of the Fc gammaRIIA gene, who have less capacity to opsonize IgG2 antibodies, may also be protected from DHF (one-tailed P = 0.03).	Arginine	20-28	Fc gamma receptor IIa	Homo sapiens	60-72
12172963-6	2002	Deletion of UPF1, or deletion of UPF2 and UPF3, the other genes involved in the NMD pathway, enhances the synthesis of CPSase A, whether arginine is present or not in the growth medium.	Arginine	137-145	Nmd2p	Saccharomyces cerevisiae S288C	33-37
12172963-6	2002	Deletion of UPF1, or deletion of UPF2 and UPF3, the other genes involved in the NMD pathway, enhances the synthesis of CPSase A, whether arginine is present or not in the growth medium.	Arginine	137-145	Upf3p	Saccharomyces cerevisiae S288C	42-46
12135568-0	2002	An Arg/Lys--&gt;Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis.	Arginine	3-6	myelin basic protein	Mus musculus	49-69
12135568-3	2002	Since there is no known codon for citrulline, we have constructed a mutant form of recombinant murine MBP (rmMBP) in which 5 Arg and 1 Lys residues have been replaced by Gln as the most reasonable analogue of Cit.	Arginine	125-128	myelin basic protein	Mus musculus	102-105
12135568-4	2002	The residues were chosen to correspond to the 6 Arg residues in human MBP which are most commonly deiminated in chronic MS.	Arginine	48-51	myelin basic protein	Homo sapiens	70-73
12055234-4	2002	Mutated forms of KIR2DL4 were engineered that lacked either the tyrosine in the ITIM or an arginine-tyrosine motif in the transmembrane region that is required for the activation signal.	Arginine	91-99	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	17-24
12060683-4	2002	Here, we have analysed the transcriptional activity of a Hoxa1(NA-KR) mutant for which the asparagine and alanine residues of the homeodomain have been replaced by lysine and arginine, respectively.	Arginine	175-183	homeobox A1	Homo sapiens	57-62
12024017-2	2002	The transactivator Gcn4p is required for activation in minimal medium, while arginine repression requires the ArgR/Mcm1 regulatory complex, which binds to two upstream arginine control elements.	Arginine	168-176	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	19-24
17010801-6	2006	We identified 1 family with a deletion of arginine 14 in the PLN.	Arginine	42-50	phospholamban	Homo sapiens	61-64
11864969-3	2002	We report here our pre-steady-state kinetic analysis of a kinesin switch I mutant at Arg(210) (NXXSSRSH, residues 205-212 in Drosophila kinesin).	Arginine	85-88	Kinesin heavy chain	Drosophila melanogaster	58-65
11864969-3	2002	We report here our pre-steady-state kinetic analysis of a kinesin switch I mutant at Arg(210) (NXXSSRSH, residues 205-212 in Drosophila kinesin).	Arginine	85-88	Kinesin heavy chain	Drosophila melanogaster	136-143
16919264-1	2006	Nitric oxide synthase (NOS) converts L-arginine into nitric oxide (NO) and L-citrulline.	Arginine	37-47	nitric oxide synthase, inducible	Cavia porcellus	0-21
11934692-2	2002	We identified arginine-188 of ROMK1 as a critical residue for this interaction.	Arginine	14-22	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	30-35
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Arginine	34-42	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	156-161
11934692-5	2002	These results indicate that, like arginine-188, lysine-181, arginine-217, and lysine-218 are also involved in interactions with PIP(2) and are critical for ROMK1 to open at full conductance.	Arginine	60-68	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	156-161
16781079-4	2006	Furthermore, nNOS also generates superoxide (.O(2)(-)) at low levels of L-arginine.	Arginine	72-82	nitric oxide synthase 1	Homo sapiens	13-17
11917138-4	2002	After duplication, substitutions at two interacting sites (Arg-64--&gt;Ser and Thr-132--&gt;Arg) resulted in a 13-fold enhancement of the ribonucleolytic activity of eosinophil-derived neurotoxin.	Arginine	59-62	ribonuclease A family member 2	Homo sapiens	166-195
11917138-4	2002	After duplication, substitutions at two interacting sites (Arg-64--&gt;Ser and Thr-132--&gt;Arg) resulted in a 13-fold enhancement of the ribonucleolytic activity of eosinophil-derived neurotoxin.	Arginine	92-95	ribonuclease A family member 2	Homo sapiens	166-195
16888649-3	2006	As in yeast, mutation of K164 of PCNA to arginine in the avian cell line DT40 results in sensitivity to DNA damage but, by contrast, the DT40 pcnaK164R mutant is more sensitive than the rad18 mutant.	Arginine	41-49	proliferating cell nuclear antigen	Saccharomyces cerevisiae S288C	33-37
11956086-7	2002	These observations emphasize the general importance of the arginine at amino acid 482 for substrate specificity of the transporter, while reminding us that unmutated Bcrp1 remains a potential source of resistance to anthracyclines and a potential factor in anthracycline pharmacokinetics.	Arginine	59-67	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	166-171
11884610-9	2002	In model p107 spacer region peptides, phosphorylation of S640 by cyclin D1/Cdk4 is strictly dependent upon an intact RXL motif, but phosphorylation of this site in the absence of an RXL motif can be partially restored by replacement of S643 by arginine.	Arginine	244-252	cyclin D1	Homo sapiens	65-74
16310386-1	2006	[Arg(91), Ala(96)] MBP(87-99) is an altered peptide ligand (APL) of myelin basic protein (MBP), shown to actively inhibit experimental autoimmune encephalomyelitis (EAE), which is studied as a model of multiple sclerosis (MS).	Arginine	1-4	myelin basic protein	Homo sapiens	19-22
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Arginine	53-61	prion protein	Mus musculus	104-107
11751874-2	2002	The transport-competent precursor of the brush border enzyme LPH, pro-LPH, undergoes an intracellular cleavage process in the trans-Golgi network between Arg(734) and Leu(735) to yield LPH beta(initial).	Arginine	154-157	lactase	Homo sapiens	61-64
11751874-2	2002	The transport-competent precursor of the brush border enzyme LPH, pro-LPH, undergoes an intracellular cleavage process in the trans-Golgi network between Arg(734) and Leu(735) to yield LPH beta(initial).	Arginine	154-157	lactase	Homo sapiens	70-73
11751874-2	2002	The transport-competent precursor of the brush border enzyme LPH, pro-LPH, undergoes an intracellular cleavage process in the trans-Golgi network between Arg(734) and Leu(735) to yield LPH beta(initial).	Arginine	154-157	lactase	Homo sapiens	70-73
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Arginine	53-61	prion protein	Mus musculus	161-164
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Arginine	53-61	prion protein	Mus musculus	161-164
16912302-4	2006	It has been proposed that two putative asparagine-to-arginine intrahelical salt bridges stabilize H1 in PrP(C) yet form intermolecular ionic bonds with adjacent PrP molecules during conversion of PrP(C) to PrP(Sc) (M. P. Morrissey and E. I. Shakhnovich, Proc.	Arginine	53-61	prion protein	Mus musculus	161-164
11867765-8	2002	By using this site-specific probe of binding, we analyze the effect of mutating the conserved arginine residue in the sensor-2 motif in Hsp104 NBD2.	Arginine	94-102	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	136-142
17086290-6	2006	Comparing with the codon frequence of Chinese hamster, the highest frequence of synonymous codons for amino acids in CHO dhfr- cells were the same as Chinese hamster except that of Arg and Pro.	Arginine	181-184	dihydrofolate reductase	Cricetulus griseus	121-125
11972440-6	2002	To date, only the Arg(16) polymorphism appears to be important in determining beta 2-agonist drug responses but the data as well as their application are limited.	Arginine	18-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	78-84
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Arginine	40-48	cyclin D1	Homo sapiens	166-175
11939506-0	2002	Hb A2-Monreale [delta146(HC3)His-->Arg], a novel delta chain variant detected in west Sicily.	Arginine	35-38	hemoglobin subunit alpha 2	Homo sapiens	0-5
16842881-7	2006	The numbers of green fluorescent protein (GFP)-positive and HMGB1-negative cells indicated that PAMAM-Arg/shRNA-expressing plasmid complex suppressed target gene expression in over 40% of cells, which is the highest level achieved to date in primary cortical culture by any gene carrier.	Arginine	102-105	high mobility group box 1	Homo sapiens	60-65
11857920-5	2002	Functional mutations of the GnRHR are distributed widely throughout the protein, although the hot spots are Gln(106) Arg and Arg (262) Gln.	Arginine	117-120	gonadotropin releasing hormone receptor	Homo sapiens	28-33
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	0-8	growth differentiation factor 10	Rattus norvegicus	371-374
11812141-7	2002	The structural studies of the complex formed between 10G6D6 and 6-CMO-estradiol have identified contacts between the 6-CMO coupling linker and an arginine residue from the heavy chain CDR2 segment.	Arginine	146-154	cerebellar degeneration related protein 2	Homo sapiens	184-188
11784132-9	2002	In addition, the analogue cyclo(87-99)[Arg(91), Ala(96)]MBP(87-99) induced proliferation of human peripheral blood T-cells.	Arginine	39-42	myelin basic protein	Homo sapiens	56-59
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	159-167	growth differentiation factor 10	Rattus norvegicus	371-374
16849482-4	2006	V(H) sequences were derived from IS4 by altering the number of Arg residues in CDR3.	Arginine	63-66	CDR3	Homo sapiens	79-83
16849482-7	2006	Of four Arg residues in IS4VH CDR3 substituted to Ser, two at positions 100 and 100g, reduced binding to all Ags, while two at positions 96 and 97 reduced binding to beta2GPI but increased or decreased binding to different PL.	Arginine	8-11	CDR3	Homo sapiens	30-34
16704975-5	2006	A single arginine-rich nuclear localization sequence of Rev is required for interaction with all importins tested so far.	Arginine	9-17	Rev	Human immunodeficiency virus 1	56-59
16713997-5	2006	Co-incubation with l-arginine enhanced PD, inhibited senescence associated beta-galactosidase activity, and increased telomerase activity.	Arginine	19-29	galactosidase beta 1	Homo sapiens	75-93
12793052-8	2003	NO is a chemical messenger which is formed during oxidation of L-arginine to L-citrullin by the action of the enzyme NO synthase (NOS).	Arginine	63-73	nitric oxide synthase 1	Homo sapiens	117-128
16809279-0	2006	Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection.	Arginine	11-19	tripartite motif containing 5	Homo sapiens	37-47
12540837-0	2003	Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity.	Arginine	43-51	carnitine palmitoyltransferase 1B	Rattus norvegicus	113-145
16809279-4	2006	The increase in restricting activity correlated with an increase in the ability of TRIM5alpha(hu) mutants lacking arginine 332 to bind HIV-1 capsid complexes.	Arginine	114-122	tripartite motif containing 5	Homo sapiens	83-93
16809279-8	2006	Therapeutic strategies designed to neutralize arginine 332 of TRIM5alpha(hu) might potentiate the innate resistance of human cells to HIV-1 infection.	Arginine	46-54	tripartite motif containing 5	Homo sapiens	62-72
16845475-6	2006	Second, dramatic increases in transcripts for arginase 1 (ARG1), the enzymes of polyamine biosynthesis, and protein inhibitor of nitric oxide synthase (NOS) activity indicate that NO production may be regulated, in part, by inhibition of NOS and coordinate depletion of the NOS substrate, L: -arginine.	Arginine	289-301	arginase, liver	Mus musculus	46-56
12628472-1	2003	Nitric oxide (NO) is synthesized from L-arginine by neuronal, endothelial and inducible isoforms of NO synthase (nNOS, eNOS and iNOS, respectively) and is involved in the regulation of a variety of physiological functions, including immune activity.	Arginine	38-48	nitric oxide synthase 1	Homo sapiens	113-117
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide receptor 2	Homo sapiens	219-226
12475394-3	2003	Comparison of the binding and functional properties of related VIP analogues suggested that the VPAC(1) selectivity of Arg(11)-VIP was due to the loss of a hydrogen bond between the hydroxy group of Thr residue and the VPAC(2) receptor, steric hindrance between the Arg side chain and the VPAC(2) receptor and charge attraction by the VPAC(1) receptor.	Arginine	119-122	vasoactive intestinal peptide receptor 2	Homo sapiens	289-296
16845475-6	2006	Second, dramatic increases in transcripts for arginase 1 (ARG1), the enzymes of polyamine biosynthesis, and protein inhibitor of nitric oxide synthase (NOS) activity indicate that NO production may be regulated, in part, by inhibition of NOS and coordinate depletion of the NOS substrate, L: -arginine.	Arginine	289-301	arginase, liver	Mus musculus	58-62
12514189-5	2003	Although the ADAMTS-9 zymogen has many proprotein convertase processing sites, pulse-chase analysis, site-directed mutagenesis, and amino acid sequencing demonstrated that maturation to the active form occurs by selective proprotein convertase (e.g. furin) cleavage of the Arg(287)-Phe(288) bond.	Arginine	273-276	furin, paired basic amino acid cleaving enzyme	Homo sapiens	250-255
16627486-2	2006	Some receptors contain a TM arginine residue that interacts with Asp-11 of the FcRgamma subunit, but otherwise the molecular basis for the FcRgamma subunit interactions is largely unknown.	Arginine	28-36	Fc epsilon receptor Ig	Homo sapiens	79-87
16627486-2	2006	Some receptors contain a TM arginine residue that interacts with Asp-11 of the FcRgamma subunit, but otherwise the molecular basis for the FcRgamma subunit interactions is largely unknown.	Arginine	28-36	Fc epsilon receptor Ig	Homo sapiens	139-147
16713055-3	2006	We have demonstrated that NOS1, in the presence of L-arginine, can biotransform ethanol (EtOH) to alpha-hydroxyethyl radical (CH3*CHOH).	Arginine	51-61	nitric oxide synthase 1	Homo sapiens	26-30
12673280-8	2003	We detected two disease-associated mutations in patients with Robin sequence, an Arg to stop codon mutation in COL11A2 and a splicing mutation in COL11A1.	Arginine	81-84	collagen type XI alpha 2 chain	Homo sapiens	111-118
16713055-4	2006	We now report that a competent NOS2 with l-arginine can, like NOS1, oxidize EtOH to CH3*CHOH.	Arginine	41-51	nitric oxide synthase 1	Homo sapiens	62-66
12667823-5	2003	Further studies with various mutated forms of Tat showed that its Cys-rich region, rather than the core and Arg-rich domains, was essential for this strand transfer activity.	Arginine	108-111	tyrosine aminotransferase	Homo sapiens	46-49
16601116-2	2006	In the endoplasmic reticulum (ER), profurin folds under the guidance of its prodomain and undergoes an autoproteolytic excision at the consensus furin site Arg-Thr-Lys-Arg107/ generating an enzymatically masked furin-propeptide complex competent for transport to late secretory compartments.	Arginine	156-159	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
16601116-2	2006	In the endoplasmic reticulum (ER), profurin folds under the guidance of its prodomain and undergoes an autoproteolytic excision at the consensus furin site Arg-Thr-Lys-Arg107/ generating an enzymatically masked furin-propeptide complex competent for transport to late secretory compartments.	Arginine	156-159	furin, paired basic amino acid cleaving enzyme	Homo sapiens	145-150
16569739-6	2006	The position of arginine at codon 96 was modeled using the CYP17 structure 2c17 (www.rcsb.org).	Arginine	16-24	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	59-64
12610310-2	2003	Here we report that an inherited human dilated cardiomyopathy with refractory congestive heart failure is caused by a dominant Arg --&gt; Cys missense mutation at residue 9 (R9C) in phospholamban (PLN), a transmembrane phosphoprotein that inhibits the cardiac sarcoplasmic reticular Ca2+-adenosine triphosphatase (SERCA2a) pump.	Arginine	127-130	phospholamban	Homo sapiens	197-200
16699504-0	2006	Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.	Arginine	49-57	PR domain containing 1, with ZNF domain	Mus musculus	0-6
12591617-9	2003	Mutations in selected sites showed the importance of Asp-73, Cys-104, Arg-110 and Ser-111 in phosphatase activity of DUSP18.	Arginine	70-73	dual specificity phosphatase 18	Homo sapiens	117-123
16699504-3	2006	Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-specific histone methyltransferase, which mediates symmetrical dimethylation of arginine 3 on histone H2A and/or H4 tails (H2A/H4R3me2s).	Arginine	65-73	PR domain containing 1, with ZNF domain	Mus musculus	19-25
16699504-3	2006	Here, we show that Blimp1 has a novel interaction with Prmt5, an arginine-specific histone methyltransferase, which mediates symmetrical dimethylation of arginine 3 on histone H2A and/or H4 tails (H2A/H4R3me2s).	Arginine	65-73	protein arginine N-methyltransferase 5	Mus musculus	55-60
12578987-5	2003	Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp.	Arginine	106-109	purinergic receptor P2Y12	Homo sapiens	26-33
12578987-5	2003	Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp.	Arginine	224-227	purinergic receptor P2Y12	Homo sapiens	26-33
16410053-2	2006	As they compete for the same substrate, L-arginine, an interdependence of NOS-2 and arginase-1 has been repeatedly observed in cells where arginase-1 is cytokine-inducible.	Arginine	40-50	arginase 1	Rattus norvegicus	84-94
16410053-2	2006	As they compete for the same substrate, L-arginine, an interdependence of NOS-2 and arginase-1 has been repeatedly observed in cells where arginase-1 is cytokine-inducible.	Arginine	40-50	arginase 1	Rattus norvegicus	139-149
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Arginine	82-90	p21 (RAC1) activated kinase 1	Homo sapiens	150-154
16680368-2	2006	Pos5p, existing in the mitochondrial matrix, is critical for higher temperature endurance and mitochondrial functions, such as glycerol usability and arginine biosynthesis.	Arginine	150-158	NADH kinase	Saccharomyces cerevisiae S288C	0-5
12546649-6	2003	Furthermore, Arg(34) of the human OTR, which corresponds to Arg(46) of the rat V(1a)R, provided agonist-specific binding epitopes in the OTR, indicating a conserved function of this locus throughout this GPCR subfamily.	Arginine	13-16	oxytocin receptor	Homo sapiens	34-37
12546649-6	2003	Furthermore, Arg(34) of the human OTR, which corresponds to Arg(46) of the rat V(1a)R, provided agonist-specific binding epitopes in the OTR, indicating a conserved function of this locus throughout this GPCR subfamily.	Arginine	13-16	oxytocin receptor	Rattus norvegicus	137-140
12546649-6	2003	Furthermore, Arg(34) of the human OTR, which corresponds to Arg(46) of the rat V(1a)R, provided agonist-specific binding epitopes in the OTR, indicating a conserved function of this locus throughout this GPCR subfamily.	Arginine	60-63	oxytocin receptor	Homo sapiens	34-37
16371438-1	2006	L-arginine transport is crucial for macrophage activation because it supplies substrate for the key enzymes nitric oxide synthase 2 and arginase I.	Arginine	0-10	arginase, liver	Mus musculus	136-146
12546649-6	2003	Furthermore, Arg(34) of the human OTR, which corresponds to Arg(46) of the rat V(1a)R, provided agonist-specific binding epitopes in the OTR, indicating a conserved function of this locus throughout this GPCR subfamily.	Arginine	60-63	oxytocin receptor	Rattus norvegicus	137-140
12441343-10	2003	Pancreasin"s preferences for hydrolysis of extended peptide substrates feature a strong preference for P1 Arg and differ from those of trypsin.	Arginine	106-109	serine protease 27	Homo sapiens	0-10
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Arginine	35-38	aldehyde dehydrogenase 2 family member	Homo sapiens	14-19
12441350-7	2003	However, in the first inner loop, a substitution of three Ala residues for Met(128)-Arg(129)-Asn(130) abolished the ability to activate SRF only in F(q/11) cells, suggesting that this mutation might specifically disrupt the coupling to G(12/13) rather than to G(q/11).	Arginine	84-87	serum response factor	Mus musculus	136-139
16423829-4	2006	We previously reported that Btn1p is required for vacuolar pH maintenance and ATP-dependent vacuolar arginine transport.	Arginine	101-109	amino acid transporter YHC3	Saccharomyces cerevisiae S288C	28-33
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Arginine	159-167	TER94	Drosophila melanogaster	130-133
12517306-6	2003	The yeast arg11 mutant, which is deficient in Ort1p/Arg11p grows poorly on media lacking arginine.	Arginine	89-97	Ort1p	Saccharomyces cerevisiae S288C	10-15
12517306-6	2003	The yeast arg11 mutant, which is deficient in Ort1p/Arg11p grows poorly on media lacking arginine.	Arginine	89-97	Ort1p	Saccharomyces cerevisiae S288C	46-51
16525503-5	2006	Strikingly, a stretch of four basic amino acids in the ubiquitin chain assembly factor E4B was also discovered to be critical for VCP binding, indicating that arginine/lysine-rich motifs might be generally utilized by VCP for the targeting of proteins.	Arginine	159-167	TER94	Drosophila melanogaster	218-221
16497569-0	2006	Oxidation of Arg-410 promotes the elimination of human serum albumin.	Arginine	13-16	albumin	Mus musculus	55-68
12661899-8	2003	Addition of L-arginine (L-arg) reversed the AG effect on IL-6 and MIP-2 expression.	Arginine	12-22	C-X-C motif chemokine ligand 2	Rattus norvegicus	66-71
12661899-8	2003	Addition of L-arginine (L-arg) reversed the AG effect on IL-6 and MIP-2 expression.	Arginine	12-17	C-X-C motif chemokine ligand 2	Rattus norvegicus	66-71
16533895-0	2006	A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.	Arginine	61-69	cyclic nucleotide gated channel subunit alpha 2	Homo sapiens	115-120
12524231-1	2003	OBJECTIVE: L-arginine serves as a substrate for the formation of NO by the NO synthase (NOS) enzymes.	Arginine	11-21	nitric oxide synthase 1, neuronal	Mus musculus	75-86
12522074-1	2003	1 When nitric oxide synthase (NOS) produces NO from N(G)-hydroxy-L-arginine (OH-arginine) instead of L-arginine, the total requirement of molecular oxygen and NADPH to form NO is reduced.	Arginine	65-75	nitric oxide synthase, brain	Oryctolagus cuniculus	7-28
16594917-0	2006	Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract.	Arginine	128-136	matrix metallopeptidase 2	Homo sapiens	14-40
12576087-5	2003	All the endogenous (POMC-derived) melanocortin agonists contain the putative message sequence "His-Phe-Arg-Trp."	Arginine	103-106	pro-opiomelanocortin-alpha	Mus musculus	20-24
12576087-6	2003	Herein, we report 12 tetrapeptides, based upon the template Ac-His(6)-DPhe(7)-Arg(8)-Trp(9)-NH(2) (alpha-MSH numbering) that have been modified at the Arg(8) position by neutral, basic, or acidic amino acid side chains.	Arginine	78-81	pro-opiomelanocortin-alpha	Mus musculus	99-108
16430207-4	2006	One residue, Arg(6), was found to be essential for receptor antagonism; its replacement with either alanine or lysine completely abolished the interaction between AF17121 and IL5Ralpha.	Arginine	13-16	interleukin 5 receptor subunit alpha	Homo sapiens	175-184
16432188-2	2006	Through genetic screening of dilated cardiomyopathy patients, we identified a previously uncharacterized deletion of arginine 14 (PLN-R14Del) in the coding region of the phospholamban (PLN) gene in a large family with hereditary heart failure.	Arginine	117-125	phospholamban	Homo sapiens	130-133
12943540-9	2003	Our results also indicate that the motif containing Asn-98 and specific charged residues in K1 (Glu-97 in PI and Arg-102 in AP3) are important for both the strength and specificity of AP3/PI heterodimer formation.	Arginine	113-116	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	124-127
12943540-9	2003	Our results also indicate that the motif containing Asn-98 and specific charged residues in K1 (Glu-97 in PI and Arg-102 in AP3) are important for both the strength and specificity of AP3/PI heterodimer formation.	Arginine	113-116	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	184-187
12943543-3	2003	All these treatments enhanced expression of a gene encoding a novel proline-rich protein (PRP1) which has C-terminal repetitive sequences containing an unusually high amount of lysine and arginine residues.	Arginine	188-196	uncharacterized protein LOC101210961	Cucumis sativus	68-88
12943543-3	2003	All these treatments enhanced expression of a gene encoding a novel proline-rich protein (PRP1) which has C-terminal repetitive sequences containing an unusually high amount of lysine and arginine residues.	Arginine	188-196	uncharacterized protein LOC101210961	Cucumis sativus	90-94
12470634-3	2002	Here, we show that ionizing radiation (IR)-induced Rad51 focus formation is reduced in Arg-deficient cells generated from a chicken B cell line by targeted disruption.	Arginine	87-90	RAD51 recombinase	Gallus gallus	51-56
16432188-2	2006	Through genetic screening of dilated cardiomyopathy patients, we identified a previously uncharacterized deletion of arginine 14 (PLN-R14Del) in the coding region of the phospholamban (PLN) gene in a large family with hereditary heart failure.	Arginine	117-125	phospholamban	Homo sapiens	185-188
16374775-1	2006	In the present work, RGDS (Arg-Gly-Asp-Ser) was immobilized on PLLA scaffolds with plasma treatment.	Arginine	27-30	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	21-25
12244096-2	2002	The SMN protein is important in small nuclear ribonucleoprotein (snRNP) assembly and interacts with snRNP proteins via arginine/glycine-rich domains.	Arginine	119-127	survival of motor neuron 1, telomeric	Homo sapiens	4-7
12244096-6	2002	Furthermore, we find that either of the two arginine/glycine-rich domains of GAR1 can provide for interaction with SMN, but removal of both results in loss of the interaction.	Arginine	44-52	survival of motor neuron 1, telomeric	Homo sapiens	115-118
16374775-5	2006	On the other hand, the PLLA scaffolds immobilized with RGES (Arg-Gly-Glu-Ser) were much less effective in promotion of ROS attachment, suggesting that the enhancement on cell attachment was mainly due to the recognition of RGDS by the adhesion receptors on the cell membrane.	Arginine	61-64	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	223-227
17012767-5	2006	An antioxidant/antiapoptotic protective role of the vGPx is also consistent with the observation that -1 frameshifting induced by the HIV-1 env-fs sequence AAAAAGA (which contains a potential "hungry" arginine codon, AGA) increases during arginine deficiency, which has been associated with increased oxidative stress.	Arginine	201-209	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	140-143
12372819-2	2002	Receptor activation by HGF is contingent upon prior proteolytic conversion of the secreted inactive single chain form (pro-HGF) into the biologically active two chain form by a single cleavage at the Arg(494)-Val(495) bond.	Arginine	200-203	hepatocyte growth factor	Homo sapiens	23-26
12372819-8	2002	Experiments with another mutant form, HGF(Arg(494) --&gt; Glu), indicated that cleavage at the K4 site was independent of a prior cleavage at the primary, kinetically preferred Arg(494)-Val(495) site.	Arginine	42-45	hepatocyte growth factor	Homo sapiens	38-41
11784811-3	2002	Here we show that KCNQ2/KCNQ3 channels carrying a novel BFNC-causing mutation leading to an arginine to tryptophan substitution in the voltage-sensing S4 domain of KCNQ2 subunits (R214W) displayed slower opening and faster closing kinetics and a decreased voltage sensitivity with no concomitant changes in maximal current or plasma membrane expression.	Arginine	92-100	potassium voltage-gated channel subfamily Q member 3	Homo sapiens	24-29
11812267-1	2002	Nitric oxide (NO), a molecular messenger synthesized by nitric oxide synthase (NOS) from L-arginine and molecular oxygen, is involved in a number of physiological and pathological processes in mammalians.	Arginine	89-99	nitric oxide synthase 1	Homo sapiens	56-77
12446594-8	2002	Surprisingly, the greatest difference in enzymatic activities was a marked increase in 17alpha-hydroxylase activity of P450c17 in the baboon, which differs from rhesus only at residue 255 [arginine (Arg) in baboon, histine (His) in rhesus].	Arginine	189-197	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	119-126
16344361-2	2006	Inflammatory cell activation stimulates uptake of arginine (the precursor for nitric oxide) by transport system y+, expression of one of its genes (CAT-2) together with inducible nitric oxide synthase, leading to nitric oxide production.	Arginine	50-58	solute carrier family 7 member 2	Homo sapiens	148-153
12446594-8	2002	Surprisingly, the greatest difference in enzymatic activities was a marked increase in 17alpha-hydroxylase activity of P450c17 in the baboon, which differs from rhesus only at residue 255 [arginine (Arg) in baboon, histine (His) in rhesus].	Arginine	199-202	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	119-126
16543750-7	2006	RESULTS: A compound heterozygous AAAS mutation consisting of two mutations was found: a C &gt; T transition in exon 7 resulting in a change of arginine at amino acid position 194 into a stop codon (Arg194X) at one allele, and a C &gt; T transition in exon 12 resulting in a change of glutamine at amino acid position 387 into a stop codon (Gln387X) on the other allele.	Arginine	143-151	aladin WD repeat nucleoporin	Homo sapiens	33-37
12468569-5	2002	The NO substrate L-arginine augmented downregulation of the AT1a receptor in VSMCs from WKY, whereas it did not affect expression of the AT1a receptor in VSMCs from SHR.	Arginine	17-27	angiotensin II receptor, type 1a	Rattus norvegicus	60-64
11701890-2	2001	The CBP/p300 methylation site is localized to an arginine residue that is essential for stabilizing the structure of the KIX domain, which mediates CREB recruitment.	Arginine	49-57	E1A binding protein p300	Homo sapiens	8-12
11752426-8	2001	One of the Janus kinases, human TYK2, has an SH2 domain that contains a histidine instead of the conserved arginine at the key phosphotyrosine-binding position, betaB5.	Arginine	107-115	tyrosine kinase 2	Homo sapiens	32-36
12414939-0	2002	Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.	Arginine	55-63	tegument protein US11	Human alphaherpesvirus 1	92-96
17051348-2	2006	Since L-Arg supply may limit nitric oxide synthase (NOS) activity in endothelial cells, we examined L-Arg supplementation in differentiating mouse myoblasts and tested the hypothesis that L-Arg exerts direct effects on myoblast fusion via augmentation of endogenous nitric oxide production.	Arginine	6-11	nitric oxide synthase 1, neuronal	Mus musculus	29-50
12414939-1	2002	The herpes simplex virus Us11 gene product inhibits activation of the cellular PKR kinase and associates with a limited number of unrelated viral and cellular RNA molecules via a carboxyl-terminal 68-amino-acid segment rich in arginine and proline.	Arginine	227-235	tegument protein US11	Human alphaherpesvirus 1	25-29
12414939-13	2002	The arginine- and proline-rich Us11 RNA binding domain is unrelated to known dsRNA binding elements and thus constitutes a unique recognition motif that interacts with dsRNA.	Arginine	4-12	tegument protein US11	Human alphaherpesvirus 1	31-35
12415268-3	2002	The gene associated with von Hippel-Lindau syndrome, VHL, maps to this region, and homozygosity with respect to a C--&gt;T missense mutation in VHL, causing an arginine-to-tryptophan change at amino-acid residue 200 (Arg200Trp), was identified in all individuals affected with Chuvash polycythemia.	Arginine	160-168	von Hippel-Lindau tumor suppressor	Homo sapiens	53-56
11744335-4	2001	Nitric oxide synthase activity was measured in isolated brain and liver mitochondria using the arginine to citrulline conversion assay.	Arginine	95-103	nitric oxide synthase 1, neuronal	Mus musculus	0-21
12415268-3	2002	The gene associated with von Hippel-Lindau syndrome, VHL, maps to this region, and homozygosity with respect to a C--&gt;T missense mutation in VHL, causing an arginine-to-tryptophan change at amino-acid residue 200 (Arg200Trp), was identified in all individuals affected with Chuvash polycythemia.	Arginine	160-168	von Hippel-Lindau tumor suppressor	Homo sapiens	144-147
11741585-0	2001	Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.	Arginine	102-105	laminin, alpha 5	Mus musculus	14-28
16408119-10	2006	Western blotting revealed that CAT-1 protein was decreased in CRF, but remained intact following arginine and atorvastatin administration.	Arginine	97-105	solute carrier family 7 member 1	Rattus norvegicus	31-36
16408119-11	2006	Renal and systemic arginine uptake is attenuated in CRF, through modulation of CAT-1 protein.	Arginine	19-27	solute carrier family 7 member 1	Rattus norvegicus	79-84
16263090-5	2005	Characterization of the FGF3 binding domain of rpS2 showed that both the Arg-Gly-rich N-terminal region and a short carboxyl-terminal sequence of rpS2 are necessary for FGF3 binding.	Arginine	73-76	fibroblast growth factor 3	Homo sapiens	24-28
11724583-1	2001	Plasmin (Pm), the main fibrinolytic protease in the plasma, is derived from its zymogen plasminogen (Plg) by cleavage of a peptide bond at Arg(561)-Val(562).	Arginine	139-142	plasminogen	Homo sapiens	88-99
11724583-1	2001	Plasmin (Pm), the main fibrinolytic protease in the plasma, is derived from its zymogen plasminogen (Plg) by cleavage of a peptide bond at Arg(561)-Val(562).	Arginine	139-142	plasminogen	Homo sapiens	101-104
16289022-3	2005	The proprotein convertases, furin, PACE4, and PC5/6 efficiently removed the prodomain through cleavage at Arg(212)/Phe(213), generating an active enzyme.	Arginine	106-109	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
11860470-1	2001	Excitotoxic neuronal cell death is characterized by an overactivation of glutamate receptors, in particular of the NMDA subtype, and the stimulation of the neuronal nitric oxide synthase (nNOS), which catalyses the formation of nitric oxide (NO) from l-arginine (L-Arg).	Arginine	251-261	nitric oxide synthase 1	Homo sapiens	156-186
11860470-1	2001	Excitotoxic neuronal cell death is characterized by an overactivation of glutamate receptors, in particular of the NMDA subtype, and the stimulation of the neuronal nitric oxide synthase (nNOS), which catalyses the formation of nitric oxide (NO) from l-arginine (L-Arg).	Arginine	251-261	nitric oxide synthase 1	Homo sapiens	188-192
12368908-3	2002	The mutation was found in the regulatory factor that binds X-box 5 (RFX5) and was mapped to one of the arginines in a DNA-binding surface of this protein.	Arginine	103-112	regulatory factor X5	Homo sapiens	68-72
11860470-1	2001	Excitotoxic neuronal cell death is characterized by an overactivation of glutamate receptors, in particular of the NMDA subtype, and the stimulation of the neuronal nitric oxide synthase (nNOS), which catalyses the formation of nitric oxide (NO) from l-arginine (L-Arg).	Arginine	263-268	nitric oxide synthase 1	Homo sapiens	156-186
12429874-4	2002	During arginine infusion, peak plasma insulin was lower in DM1 than in DM2 (p &lt; 0.05) and CON (p &lt; 0.01).	Arginine	7-15	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	71-74
16289022-3	2005	The proprotein convertases, furin, PACE4, and PC5/6 efficiently removed the prodomain through cleavage at Arg(212)/Phe(213), generating an active enzyme.	Arginine	106-109	proprotein convertase subtilisin/kexin type 5	Homo sapiens	46-49
12924019-5	2002	Both 10(-2) M 6-aminohexanoic acid and 10(-1) M arginine reduced the complex formation rate between plasmin, mini-plasmin and alpha 2-antiplasmin to the value of the rate reaction between micro-plasmin and inhibitor.	Arginine	48-56	plasminogen	Homo sapiens	100-107
11860470-1	2001	Excitotoxic neuronal cell death is characterized by an overactivation of glutamate receptors, in particular of the NMDA subtype, and the stimulation of the neuronal nitric oxide synthase (nNOS), which catalyses the formation of nitric oxide (NO) from l-arginine (L-Arg).	Arginine	263-268	nitric oxide synthase 1	Homo sapiens	188-192
11860470-2	2001	At low L-Arg concentrations, nNOS generates NO and superoxide (O2(.	Arginine	7-12	nitric oxide synthase 1	Homo sapiens	29-33
12924019-5	2002	Both 10(-2) M 6-aminohexanoic acid and 10(-1) M arginine reduced the complex formation rate between plasmin, mini-plasmin and alpha 2-antiplasmin to the value of the rate reaction between micro-plasmin and inhibitor.	Arginine	48-56	plasminogen	Homo sapiens	114-121
15967436-10	2005	Treatment of diabetic and non-diabetic rats with L-NAME enhanced AR activity and sorbitol accumulation, whereas NG patch and L-arginine significantly decreased AR activity and sorbitol accumulation in diabetic lenses compared to non-diabetic.	Arginine	125-135	aldo-keto reductase family 1 member B1	Rattus norvegicus	160-162
12924019-5	2002	Both 10(-2) M 6-aminohexanoic acid and 10(-1) M arginine reduced the complex formation rate between plasmin, mini-plasmin and alpha 2-antiplasmin to the value of the rate reaction between micro-plasmin and inhibitor.	Arginine	48-56	plasminogen	Homo sapiens	114-121
12487923-8	2002	The expression of ERK-1 in brain was much higher in CHM group than in L-arg group (P &lt; 0.05), the expression of MKP-1 was almost the same (P &gt; 0.05); Both of them in liver were higher in CHM group than in L-arg group (P &lt; 0.01).	Arginine	70-75	mitogen activated protein kinase 3	Rattus norvegicus	18-23
11739018-3	2001	The activity of the allelic variant or allozyme SULT1A1*1, which possesses an arginine at amino acid position 213 (Arg213) has been shown to be more thermostable than the activity of the SULT1A1*2 allozyme which possesses a histidine at this position (His213) when using p-nitrophenol as the substrate.	Arginine	78-86	sulfotransferase family 1A member 1	Homo sapiens	48-55
11739018-3	2001	The activity of the allelic variant or allozyme SULT1A1*1, which possesses an arginine at amino acid position 213 (Arg213) has been shown to be more thermostable than the activity of the SULT1A1*2 allozyme which possesses a histidine at this position (His213) when using p-nitrophenol as the substrate.	Arginine	78-86	sulfotransferase family 1A member 1	Homo sapiens	187-194
12487923-8	2002	The expression of ERK-1 in brain was much higher in CHM group than in L-arg group (P &lt; 0.05), the expression of MKP-1 was almost the same (P &gt; 0.05); Both of them in liver were higher in CHM group than in L-arg group (P &lt; 0.01).	Arginine	211-216	mitogen activated protein kinase 3	Rattus norvegicus	18-23
16325708-8	2005	The beta1-AR genotype was determined by polymerase chain reaction with restriction fragment length polymorphisms at codons 49 (serine [Ser] or glycine [Gly]) and 389 (arginine [Arg] or Gly).	Arginine	167-175	adrenoceptor beta 1	Homo sapiens	4-12
12239560-4	2002	The GTPase-activating protein (GAP) activity of Sec23 involves an arginine side chain inserted into the Sar1 active site.	Arginine	66-74	Arf family GTPase SAR1	Saccharomyces cerevisiae S288C	104-108
11714866-9	2001	After arginine was administered, there was marked improvement in the pathological changes accompanied by decreased levels of endotoxin, lipid peroxidation, activation of nuclear factor-kappaB, tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide, and nitrotyrosine staining.	Arginine	6-14	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	222-238
16325708-8	2005	The beta1-AR genotype was determined by polymerase chain reaction with restriction fragment length polymorphisms at codons 49 (serine [Ser] or glycine [Gly]) and 389 (arginine [Arg] or Gly).	Arginine	177-180	adrenoceptor beta 1	Homo sapiens	4-12
11546777-2	2001	We report here a human Siglec-like molecule (Siglec-L1) that lacks a conserved arginine residue known to be essential for optimal sialic acid recognition by previously known Siglecs.	Arginine	79-87	SIGLEC family like 1	Homo sapiens	45-54
11546777-6	2001	Thus, the single base pair mutation that replaced the arginine on human Siglec-L1 is likely to be evolutionarily related to the previously reported loss of N-glycolylneuraminic acid expression in the human lineage.	Arginine	54-62	SIGLEC family like 1	Homo sapiens	72-81
16307304-0	2005	Chemical modification studies of tryptophan, arginine and lysine residues in maize chloroplast ferredoxin:sulfite oxidoreductase.	Arginine	45-53	ferredoxin	Zea mays	95-105
11703452-6	2001	Marked elevation of bax was observed within a few hours of NOS inhibition in nNOS containing neurons, whereas pretreatment of cultures with l-arginine completely abolished this effect in almost all nNOS neurons and 8-bromo-cGMP in some neurons.	Arginine	140-150	nitric oxide synthase 1	Homo sapiens	198-202
12029097-6	2002	Additionally, site-directed mutagenesis (changing Lys to Arg in CRFR1 individually and in combination) revealed that Lys(257) in the second extracellular loop of CRFR1 is an important cross-linking site.	Arginine	57-60	corticotropin releasing hormone receptor 1	Homo sapiens	64-69
12029097-6	2002	Additionally, site-directed mutagenesis (changing Lys to Arg in CRFR1 individually and in combination) revealed that Lys(257) in the second extracellular loop of CRFR1 is an important cross-linking site.	Arginine	57-60	corticotropin releasing hormone receptor 1	Homo sapiens	162-167
16307304-8	2005	Treatment of sulfite reductase with the arginine-modifying reagent, phenylglyoxal, inhibited both the ferredoxin-linked and methyl viologen-linked activities of the enzyme but had a significantly greater effect on the ferredoxin-dependent activity than on the reduced methyl viologen-linked activity.	Arginine	40-48	ferredoxin	Zea mays	102-112
16307304-8	2005	Treatment of sulfite reductase with the arginine-modifying reagent, phenylglyoxal, inhibited both the ferredoxin-linked and methyl viologen-linked activities of the enzyme but had a significantly greater effect on the ferredoxin-dependent activity than on the reduced methyl viologen-linked activity.	Arginine	40-48	ferredoxin	Zea mays	218-228
16307304-9	2005	The effects of these three inhibitory treatments are consistent with a possible role for a tryptophan residue the catalytic mechanism of sulfite reductase and for lysine and arginine residues at the ferredoxin-binding site of the enzyme.	Arginine	174-182	ferredoxin	Zea mays	199-209
12093795-3	2002	The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176).	Arginine	75-78	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
16251276-1	2005	Every residue of the 101-aa Escherichia coli toxin CcdB was substituted with Ala, Asp, Glu, Lys, and Arg by using site-directed mutagenesis.	Arginine	101-104	hypothetical protein	Escherichia coli	51-55
12093795-3	2002	The amino acids comprising the catalytic center of G6Pase include Lys(76), Arg(83), His(119), Arg(170), and His(176).	Arginine	94-97	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
12115475-5	2002	To encourage cell adhesion, PEUUs were surface modified with radio-frequency glow discharge followed by coupling of Arg-Gly-Asp-Ser (RGDS).	Arginine	116-119	ral guanine nucleotide dissociation stimulator	Homo sapiens	133-137
16304337-0	2005	L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9.	Arginine	0-10	matrix metallopeptidase 2	Rattus norvegicus	73-130
12203991-14	2002	The majority of these mutations are C to T transitions, changing an arginine residue (CGA) to a stop codon (TGA).	Arginine	68-76	T-box transcription factor 1	Homo sapiens	108-111
16304337-1	2005	STUDY OBJECTIVES: To evaluate the effects of L-arginine on acute pulmonary embolism (APE)-induced pulmonary hypertension and increases in lung matrix metalloproteinase (MMP)-2 and MMP-9 activities.	Arginine	45-55	matrix metallopeptidase 2	Rattus norvegicus	143-175
16304337-10	2005	While L-arginine at 0.5 mmol/L produced no effect on MMPs, L-arginine 3 at mmol/L and 10 mmol/L attenuated the increases in MMP-2 and MMP-9 activities after APE (both p &lt; 0.05).	Arginine	59-69	matrix metallopeptidase 2	Rattus norvegicus	124-129
16304337-11	2005	CONCLUSIONS: L-arginine attenuates APE-induced pulmonary hypertension through mechanisms involving increased NO synthesis and maybe attenuation of lung MMP-2 and MMP-9 activities.	Arginine	13-23	matrix metallopeptidase 2	Rattus norvegicus	152-157
16388095-2	2005	NO synthase (NOS) is the enzyme responsible for NO production from L-arginine and plays an important role in regulating the release of several hypothalamic peptides.	Arginine	67-77	nitric oxide synthase 1	Homo sapiens	0-11
12163582-6	2002	We conclude that Arg183 within the Pro180-Asn-Ile-Arg-Ser184 sequence of the SIN nsP4 polymerase contributes to the efficient initiation of minus strands or the formation of its replicase and that a host factor(s) participates in this event.	Arginine	17-20	serine protease 57	Homo sapiens	81-85
12176364-0	2002	A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.	Arginine	16-19	GRB2 related adaptor protein 2	Homo sapiens	94-98
16237103-0	2005	Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture.	Arginine	0-8	hepatocyte growth factor	Homo sapiens	83-107
16237103-4	2005	Arginine-specific gingipain (Rgp) caused a marked production of HGF into the supernatant, the induction of HGF expression on the cell surface, and the up-regulation of HGF mRNA expression in a dose-dependent and an enzymatic activity-dependent manner.	Arginine	0-8	hepatocyte growth factor	Homo sapiens	107-110
16237103-4	2005	Arginine-specific gingipain (Rgp) caused a marked production of HGF into the supernatant, the induction of HGF expression on the cell surface, and the up-regulation of HGF mRNA expression in a dose-dependent and an enzymatic activity-dependent manner.	Arginine	0-8	hepatocyte growth factor	Homo sapiens	107-110
12142001-2	2002	Two different classes of histone methyltransferase (HMT) have been described, which target either lysine or arginine residues in the histone N-terminal tails.	Arginine	108-116	PR/SET domain 9	Homo sapiens	25-50
12142001-2	2002	Two different classes of histone methyltransferase (HMT) have been described, which target either lysine or arginine residues in the histone N-terminal tails.	Arginine	108-116	PR/SET domain 9	Homo sapiens	52-55
16272181-1	2005	The novel human differentiating factor peptide fragment HLDF6 (Thr-Gly-Glu-Asn-His-Arg) was synthesized and purified.	Arginine	83-86	ribosomal protein S21	Homo sapiens	56-61
12098667-5	2002	The deduced TIP39 preprohormones consist of an N-terminal 30 amino acid (aa) signal peptide followed by a 29 aa TIP39 precursor-related peptide, an Arg-Arg processing site, and the actual 39 aa TIP39 sequence.	Arginine	148-151	parathyroid hormone 2	Homo sapiens	12-17
16301849-8	2005	In Korea, first family of hereditary pancreatitis with cationic trypsinogen gene mutation revealed an arginine to histidine amino acid substitution at the residue 122.	Arginine	102-110	serine protease 1	Homo sapiens	55-75
12098667-5	2002	The deduced TIP39 preprohormones consist of an N-terminal 30 amino acid (aa) signal peptide followed by a 29 aa TIP39 precursor-related peptide, an Arg-Arg processing site, and the actual 39 aa TIP39 sequence.	Arginine	152-155	parathyroid hormone 2	Homo sapiens	12-17
11959855-6	2002	This P(4) Arg is essential for efficient hydrolysis and for selectivity for MT1-MMP.	Arginine	10-13	matrix metallopeptidase 14	Homo sapiens	76-83
16131491-0	2005	A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families.	Arginine	112-120	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	133-137
16131491-5	2005	Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4).	Arginine	18-21	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	95-130
16131491-5	2005	Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4).	Arginine	18-21	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	132-144
16131491-7	2005	Mutation of two kinases (PKC-theta and p21-activated kinase 1 (PAK1)) confirmed critical roles of both PEN+1 and YEM+1 residues in determining strong R-2 Arg preference.	Arginine	154-157	p21 (RAC1) activated kinase 1	Homo sapiens	39-61
12006574-6	2002	Consistent with the need for the interaction between Arg(2) of Ang II and Ang III with Asp(281), substitution of this residue with alanine (D281A) decreased the peptide"s potency without affecting that of Ang IV.	Arginine	53-56	angiogenin	Homo sapiens	63-66
16131491-7	2005	Mutation of two kinases (PKC-theta and p21-activated kinase 1 (PAK1)) confirmed critical roles of both PEN+1 and YEM+1 residues in determining strong R-2 Arg preference.	Arginine	154-157	p21 (RAC1) activated kinase 1	Homo sapiens	63-67
16131491-8	2005	PAK kinases were unique in having exceptionally strong Arg preference at P-2 but lacking strong Arg preference at P-3.	Arginine	55-58	p21 (RAC1) activated kinase 1	Homo sapiens	0-3
16131491-8	2005	PAK kinases were unique in having exceptionally strong Arg preference at P-2 but lacking strong Arg preference at P-3.	Arginine	96-99	p21 (RAC1) activated kinase 1	Homo sapiens	0-3
12071959-6	2002	Furthermore, cotransfection of the FcR gamma-chain and two mutant versions of GPVI shows that the transmembrane arginine and cytoplasmic tail of GPVI are necessary for association with the FcR gamma-chain.	Arginine	112-120	Fc epsilon receptor Ig	Homo sapiens	35-44
12071959-6	2002	Furthermore, cotransfection of the FcR gamma-chain and two mutant versions of GPVI shows that the transmembrane arginine and cytoplasmic tail of GPVI are necessary for association with the FcR gamma-chain.	Arginine	112-120	Fc epsilon receptor Ig	Homo sapiens	189-198
16131491-9	2005	Preference for Arg at P-2 was so critical to PAK recognition that PAK1 activity was virtually eliminated by mutating the PEN+1 or YEM+1 residues.	Arginine	15-18	p21 (RAC1) activated kinase 1	Homo sapiens	45-48
16131491-9	2005	Preference for Arg at P-2 was so critical to PAK recognition that PAK1 activity was virtually eliminated by mutating the PEN+1 or YEM+1 residues.	Arginine	15-18	p21 (RAC1) activated kinase 1	Homo sapiens	66-70
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Arginine	105-108	plasminogen	Homo sapiens	0-7
16087677-0	2005	Plasmin- and thrombin-accelerated shedding of syndecan-4 ectodomain generates cleavage sites at Lys(114)-Arg(115) and Lys(129)-Val(130) bonds.	Arginine	105-108	syndecan 4	Homo sapiens	46-56
12022882-5	2002	Lys(147) and Arg(154) mutants were inhibited by TFPI approximately 2-fold slower than wild type; however, both Arg(143) and Arg(150) mutants were inhibited normally by the inhibitor.	Arginine	13-16	tissue factor pathway inhibitor	Homo sapiens	48-52
16221857-2	2005	Genomic sequences for the glutamate receptor 2 (GluR2) subunit of AMPA receptors and the GluR5 and GluR6 subunits of kainate receptors all encode a neutral glutamine (Q) residue within the channel pore that can be converted by RNA editing to a positively charged arginine (R).	Arginine	263-271	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	26-46
11988094-4	2002	The substrate of NO synthase, l-Arg, also inhibited the release of RDPase, and this effect was reversed by the NO synthase inhibitor N(omega)-nitro-l-arginine methyl ester.	Arginine	30-35	dipeptidase 1	Homo sapiens	67-73
11861638-10	2002	In vitro experiments using furin and purified EC-SOD suggest that furin proteolytically cleaves EC-SOD in the middle of the polybasic region and then requires an additional carboxypeptidase to remove the remaining lysines and arginines.	Arginine	226-235	furin, paired basic amino acid cleaving enzyme	Homo sapiens	66-71
16221857-2	2005	Genomic sequences for the glutamate receptor 2 (GluR2) subunit of AMPA receptors and the GluR5 and GluR6 subunits of kainate receptors all encode a neutral glutamine (Q) residue within the channel pore that can be converted by RNA editing to a positively charged arginine (R).	Arginine	263-271	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	48-53
11861638-11	2002	A mutation in Arg(213) renders EC-SOD resistant to furin processing.	Arginine	14-17	furin, paired basic amino acid cleaving enzyme	Homo sapiens	51-56
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	89-92	mutS homolog 2	Homo sapiens	53-57
12044965-3	2002	In this study we investigated the impact of aging on the regulation, at the gene level, of the various enzymes that synthesize L-arginine in the kidney (argininosuccinate synthetase and argininosuccinate lyase) and citrulline, the precursor of L-arginine made in the small intestine (phosphate-dependent glutaminase, carbamyl phosphate synthetase-1 and ornithine transcarbamylase).	Arginine	127-137	ornithine transcarbamylase	Rattus norvegicus	317-379
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	93-96	mutS homolog 2	Homo sapiens	53-57
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	93-96	mutS homolog 2	Homo sapiens	53-57
16044463-3	2005	After in vitro methylation of the EWS protein by GST-PRMT1, we identified 27 dimethylated arginine residues out of 30 potential methylation sites by mass spectrometry-based techniques (MALDI-TOF MS and MS/MS).	Arginine	90-98	EWS RNA binding protein 1	Homo sapiens	34-37
11799113-2	2002	The 83-residue N-terminal propeptide is autoproteolytically excised in the endoplasmic reticulum (ER) at the consensus furin site, -Arg(104)-Thr-Lys-Arg(107)-, but remains bound to furin as a potent autoinhibitor.	Arginine	132-135	furin, paired basic amino acid cleaving enzyme	Homo sapiens	119-124
16044463-5	2005	With GST-PRMT3, however, only nine dimethylated arginines, located mainly in the C-terminal region of EWS protein, could be assigned, indicating that structural determinants prevent complete methylation.	Arginine	48-57	EWS RNA binding protein 1	Homo sapiens	102-105
16098672-6	2005	Pretreatment with L-arginine (30-300 mg/kg, s.c.), a substrate of NO synthase (NOS), dose-dependently increased the tail-flick latencies in vincristine-treated mice.	Arginine	18-28	nitric oxide synthase 1, neuronal	Mus musculus	66-77
11815617-9	2002	Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.	Arginine	34-42	serine and arginine rich splicing factor 2	Homo sapiens	62-66
11815617-9	2002	Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.	Arginine	34-42	serine and arginine rich splicing factor 6	Homo sapiens	75-80
11930008-2	2002	Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with alpha(v)beta3 integrins, promotes cell attachment, and cell migration and is expressed in both synovial cells and chondrocytes in rheumatoid arthritis; however, its functional relationship to arthritis has not been known.	Arginine	64-67	secreted phosphoprotein 1	Mus musculus	0-11
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Arginine	138-141	gonadotropin releasing hormone receptor	Homo sapiens	10-56
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Arginine	138-141	gonadotropin releasing hormone 1	Homo sapiens	42-46
15967801-1	2005	The human gonadotropin-releasing hormone (GnRH) receptor is evolutionarily configured for high affinity binding of GnRH I ([Tyr(5),Leu(7),Arg(8)]GnRH) but at lower affinity for GnRH II ([His(5),Trp(7),Tyr(8)]GnRH).	Arginine	138-141	gonadotropin releasing hormone 1	Homo sapiens	115-119
16085056-1	2005	Arginine is a semi-essential amino acid that serves as sole substrate for enzymes involved in diverse cell processes including redox balance via nitric oxide synthase (NOS) and cell proliferation via arginase.	Arginine	0-8	nitric oxide synthase 1	Homo sapiens	145-166
11930008-2	2002	Osteopontin (OPN) is an extracellular matrix protein containing Arg-Gly-Asp (RGD) sequence, which interacts with alpha(v)beta3 integrins, promotes cell attachment, and cell migration and is expressed in both synovial cells and chondrocytes in rheumatoid arthritis; however, its functional relationship to arthritis has not been known.	Arginine	64-67	secreted phosphoprotein 1	Mus musculus	13-16
16085056-2	2005	Neurons that express nNOS require intracellular arginine to generate nitric oxide (NO).	Arginine	48-56	nitric oxide synthase 1	Homo sapiens	21-25
15955813-2	2005	Herein we show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing factor 30 kDa (SPF30), and the Tudor domain-containing 3 (TDRD3) proteins interacted with arginine-glycine-rich motifs in a methylarginine-dependent manner.	Arginine	190-198	survival motor neuron domain containing 1	Homo sapiens	91-113
12009031-12	2002	Nitric oxide (NO), derived from L-argin-ine, is produced by two forms(constitutive and inducible) of nitric oxide synthase (NOS).	Arginine	32-43	nitric oxide synthase 1, neuronal	Mus musculus	101-122
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	142-145	cyclin D1	Homo sapiens	22-31
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	142-145	RB transcriptional corepressor like 1	Homo sapiens	120-124
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	142-145	RB transcriptional corepressor like 1	Homo sapiens	120-124
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	146-149	cyclin D1	Homo sapiens	22-31
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	146-149	RB transcriptional corepressor like 1	Homo sapiens	120-124
15955813-2	2005	Herein we show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing factor 30 kDa (SPF30), and the Tudor domain-containing 3 (TDRD3) proteins interacted with arginine-glycine-rich motifs in a methylarginine-dependent manner.	Arginine	190-198	survival motor neuron domain containing 1	Homo sapiens	115-120
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	146-149	RB transcriptional corepressor like 1	Homo sapiens	120-124
11779864-0	2002	Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p.	Arginine	89-97	mRNA-binding protein NAB2	Saccharomyces cerevisiae S288C	0-5
11779864-10	2002	Our experiments demonstrate that arginine methylation is required for the export of Nab2p from the nucleus and therefore establish an in vivo effect of this modification.	Arginine	33-41	mRNA-binding protein NAB2	Saccharomyces cerevisiae S288C	84-89
15845873-7	2005	L-arginine administered rectally, but not intravenously, decreased the basal tone in wild-type, nNOS-/-, and W/W(v) mice.	Arginine	0-10	nitric oxide synthase 1, neuronal	Mus musculus	96-100
11870079-12	2002	Incubation of OPN-coated microbeads with porcine trophectoderm and uterine luminal epithelial cells induced Arg-Gly-Asp (RGD)-dependent integrin activation and transmembrane accumulation of cytoskeletal molecules at the apical cell surface as assessed by immunofluorescence detection of talin or alpha-actinin as markers for focal adhesions.	Arginine	108-111	secreted phosphoprotein 1	Sus scrofa	14-17
11849449-10	2002	Mild but significant improvement of tubular osteopontin expression and macrophage infiltration were observed in the medulla of L-Arg-treated hypokalemic rats.	Arginine	127-132	secreted phosphoprotein 1	Rattus norvegicus	44-55
11748242-2	2002	Mutation of Arg(117), an autocatalytic cleavage site, is the most frequent amino acid change found in the cationic trypsinogen (Tg) of patients with hereditary pancreatitis.	Arginine	12-15	serine protease 1	Homo sapiens	106-126
11719509-0	2002	Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --&gt; Cys) that alters autoactivation and autodegradation of cationic trypsinogen.	Arginine	58-61	serine protease 1	Homo sapiens	42-47
11719509-0	2002	Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --&gt; Cys) that alters autoactivation and autodegradation of cationic trypsinogen.	Arginine	58-61	serine protease 1	Homo sapiens	128-148
11563836-0	2001	Glu(191) and Asp(195) in rat mitochondrial processing peptidase beta subunit are involved in effective cleavage of precursor protein through interaction with the proximal arginine.	Arginine	171-179	peptidase, mitochondrial processing subunit beta	Rattus norvegicus	29-76
11445562-9	2001	vti1-Q158R cells had severe defects in several transport steps, indicating that the second arginine in the 0 layer interfered with function.	Arginine	91-99	v-SNARE protein VTI1	Saccharomyces cerevisiae S288C	0-4
11592819-0	2001	Arginine 387 of human isovaleryl-CoA dehydrogenase plays a crucial role in substrate/product binding.	Arginine	0-8	isovaleryl-CoA dehydrogenase	Homo sapiens	22-50
15845873-9	2005	In vitro, L-arginine decreased basal tone in wild-type and nNOS-/- IAS but not in eNOS-/- or wild-type IAS without mucosa.	Arginine	10-20	nitric oxide synthase 1, neuronal	Mus musculus	59-63
11506801-7	2001	However, in double tagA(-)alkA(-) mutant, the frequency of Arg(+) reversions increased over 10-fold during 60 min of aminoacid starvation after MMS-treatment.	Arginine	59-62	w0020	Escherichia coli	19-23
16024705-1	2005	Previous comparisons between the cDNA and gene sequences for secreted folate binding protein (sFBP) indicated a 12-bp insertion/deletion (ins/del) polymorphism in exon 1 and a SNP that altered (Ser-Arg) the protein AA sequence.	Arginine	198-201	folate receptor 1	Sus scrofa	61-92
11513586-3	2001	A structural model of v-Fps, generated from the insulin receptor, indicates that pTyr-1073 chelates two arginines.	Arginine	104-113	insulin receptor	Homo sapiens	48-64
11788388-8	2002	L-Arginine (1 mM) significantly reduced (P &lt; 0.05) myocyte contraction in the ischemic (-34 +/- 3%, P &lt; 0.05) but not (-7 +/- 4%) nonischemic regions; these responses were abolished by N(G)-nitro-L-arginine (1 mM), a nonspecific NOS inhibitor, as well as 2-amino-5,6-dihydro-6-methy-4H-1,3,thiazine (1 mM), a specific iNOS inhibitor.	Arginine	0-10	nitric oxide synthase 2	Canis lupus familiaris	324-328
16024705-1	2005	Previous comparisons between the cDNA and gene sequences for secreted folate binding protein (sFBP) indicated a 12-bp insertion/deletion (ins/del) polymorphism in exon 1 and a SNP that altered (Ser-Arg) the protein AA sequence.	Arginine	198-201	folate receptor 1	Sus scrofa	94-98
11858157-11	2002	The amino acid sequence of the active form of feline ANP (ANP-30) is identical to that of equine, bovine, and ovine ANP-30 and differs from that of human, canine, and porcine ANP-28 only by 2 carboxy-terminal arginine residues.	Arginine	209-217	natriuretic peptide A	Equus caballus	53-56
11858157-11	2002	The amino acid sequence of the active form of feline ANP (ANP-30) is identical to that of equine, bovine, and ovine ANP-30 and differs from that of human, canine, and porcine ANP-28 only by 2 carboxy-terminal arginine residues.	Arginine	209-217	natriuretic peptide A	Equus caballus	58-64
11418604-4	2001	The extended NH(2)-terminal region of hPRP4 contains an arginine/serine-rich domain and putative nuclear localization signals.	Arginine	56-64	pre-mRNA processing factor 4	Homo sapiens	38-43
16015416-0	2005	Functional determination of plasmin in arginine-stabilized plasma.	Arginine	39-47	plasminogen	Homo sapiens	28-35
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	pre-mRNA processing factor 4	Homo sapiens	13-18
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	CDC like kinase 1	Homo sapiens	44-48
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	pre-mRNA processing factor 4	Homo sapiens	110-115
11418604-7	2001	Furthermore, hPRP4 interacted directly with Clk1 on its COOH terminus, and the arginine/serine-rich domain of hPRP4 was phosphorylated by Clk1 in vitro.	Arginine	79-87	CDC like kinase 1	Homo sapiens	138-142
11858157-11	2002	The amino acid sequence of the active form of feline ANP (ANP-30) is identical to that of equine, bovine, and ovine ANP-30 and differs from that of human, canine, and porcine ANP-28 only by 2 carboxy-terminal arginine residues.	Arginine	209-217	natriuretic peptide A	Equus caballus	58-61
11834435-6	2002	RESULTS: Addition of 10 nM ghrelin to the perfusate significantly reduced the insulin response to the secretagogues glucose, arginine and carbachol, which act on the B-cell via different mechanisms, as well as the somatostatin response to arginine.	Arginine	125-133	ghrelin and obestatin prepropeptide	Rattus norvegicus	27-34
11834435-6	2002	RESULTS: Addition of 10 nM ghrelin to the perfusate significantly reduced the insulin response to the secretagogues glucose, arginine and carbachol, which act on the B-cell via different mechanisms, as well as the somatostatin response to arginine.	Arginine	239-247	ghrelin and obestatin prepropeptide	Rattus norvegicus	27-34
16015416-7	2005	For optimization of plasmin activity, the oxidation time of the arginine-stabilized plasma sample containing 0.5 U/mL active plasmin and the chloramine-T amount was varied.	Arginine	64-72	plasminogen	Homo sapiens	20-27
11511108-6	2001	Another potent and selective compound was cyclo(NH-CH(2)-CH(2)-CO-His-d-Phe-Arg-Trp-Glu)-NH(2): EC(50) about 1 nM at hMC-4R, with 90-fold selectivity over hMC-3R and greater than 2000-fold selectivity over hMC-5R.	Arginine	76-79	melanocortin 3 receptor	Homo sapiens	155-161
16015416-7	2005	For optimization of plasmin activity, the oxidation time of the arginine-stabilized plasma sample containing 0.5 U/mL active plasmin and the chloramine-T amount was varied.	Arginine	64-72	plasminogen	Homo sapiens	125-132
16015416-10	2005	The optimized functional plasmin assay consists of incubation of 10 microL arginine-stabilized plasma with 10 microL 1.5 M arginine, pH 8.7, and 10 microL 100 mM CT in PBS.	Arginine	75-83	plasminogen	Homo sapiens	25-32
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	65-68	dipeptidase 1	Homo sapiens	24-27
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	110-113	dipeptidase 1	Homo sapiens	24-27
16015416-12	2005	With the present arginine stabilization procedure of plasma and the determination of plasmin activity in arginine-stabilized plasma as described, it is feasible to determine the activity of plasmin in blood of patients receiving fibrinolytic treatment without artefactual in vitro changes in the samples.	Arginine	17-25	plasminogen	Homo sapiens	190-197
16015416-12	2005	With the present arginine stabilization procedure of plasma and the determination of plasmin activity in arginine-stabilized plasma as described, it is feasible to determine the activity of plasmin in blood of patients receiving fibrinolytic treatment without artefactual in vitro changes in the samples.	Arginine	105-113	plasminogen	Homo sapiens	85-92
16015416-12	2005	With the present arginine stabilization procedure of plasma and the determination of plasmin activity in arginine-stabilized plasma as described, it is feasible to determine the activity of plasmin in blood of patients receiving fibrinolytic treatment without artefactual in vitro changes in the samples.	Arginine	105-113	plasminogen	Homo sapiens	190-197
11454467-2	2001	The incorporated octapeptide, Gly-Pro-Gln-Arg-Ile-Ala-Gly-Gln, in A-DP2 is not cleaved by activated MMP2 and MMP9 in contrast to Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln incorporated in A-DP1 that is cleaved efficiently by activated MMP2 and MMP9 liberating a doxorubicin tetrapeptide.	Arginine	42-45	matrix metallopeptidase 9	Mus musculus	233-237
11470762-8	2001	The results of the present study clearly indicate that an arginine residue at position 216 is critical for catalytic activity of mGSTA1-1 and mGSTA2-2 toward carcinogenic diol epoxide metabolites of various PAHs that are abundant in the environment and suspected human carcinogens.	Arginine	58-66	glutathione S-transferase, alpha 2 (Yc2)	Mus musculus	142-148
15855406-5	2005	11-19) show that a novel wild-type receptor, ORF74-EHV2, which lacks the Arg residue, is fully functional, showing both constitutive and ligand-induced activation of G protein signaling.	Arginine	73-76	membrane protein G74	Equid gammaherpesvirus 2	45-50
11529920-3	2001	The sequence of TAP2 gene identified a single mutation, a C to T substitution changing the CGA arg codon at amino acid 220 into TGA stop codon in exon 3.	Arginine	95-98	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	16-20
15826943-9	2005	Marked effects on the interaction were observed in all three fibronectin type III domains of IL5Ralpha, in particular Asp(55), Arg(188), and Arg(297) in the D1, D2, and D3 domains, respectively.	Arginine	127-130	interleukin 5 receptor subunit alpha	Homo sapiens	93-102
15603814-1	2005	Chitosan scaffolds were modified with RGDS (Arg-Gly-Asp-Ser) in the present work via an imide-bond forming reaction between amino groups in chitosan and carboxyl groups in peptides.	Arginine	44-47	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	38-42
11604106-4	2001	In addition, amino acid sequence analysis of the H-CDRs of this MAb revealed the presence of three arginines, two of which are present in the H-CDR3, that could be involved in the interaction of P3 MAb with its electronegative epitope on gangliosides.	Arginine	99-108	CDR3	Homo sapiens	142-148
11479422-4	2001	As the pivotal residues around the most predominant R24C activating CDK4 mutation are invariant between CDK2 and CDK4, we speculated that the pivotal arginine (position 22 in CDK2), or a nearby residue, may be mutated in some melanomas, resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1.	Arginine	150-158	cyclin dependent kinase 4	Homo sapiens	68-72
11479422-4	2001	As the pivotal residues around the most predominant R24C activating CDK4 mutation are invariant between CDK2 and CDK4, we speculated that the pivotal arginine (position 22 in CDK2), or a nearby residue, may be mutated in some melanomas, resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1.	Arginine	150-158	cyclin dependent kinase 2	Homo sapiens	104-108
11479422-4	2001	As the pivotal residues around the most predominant R24C activating CDK4 mutation are invariant between CDK2 and CDK4, we speculated that the pivotal arginine (position 22 in CDK2), or a nearby residue, may be mutated in some melanomas, resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1.	Arginine	150-158	cyclin dependent kinase 2	Homo sapiens	175-179
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	116-124	fibroblast growth factor receptor 4	Homo sapiens	48-85
11438644-2	2001	Alanine scanning mutagenesis of the Cy motif of the cdk inhibitor p21 revealed that the conserved arginine or leucine (constituting the conserved RXL sequence) was important for p21"s ability to inhibit cyclin E-cdk2 activity.	Arginine	98-106	cyclin dependent kinase 2	Homo sapiens	212-216
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	116-124	fibroblast growth factor receptor 4	Homo sapiens	87-92
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	126-129	fibroblast growth factor receptor 4	Homo sapiens	48-85
15981099-3	2005	We further determined the allelic status of the fibroblastic growth factor receptor 4 (FGFR4) gene at position 388 (arginine [Arg(388)] or glycine [Gly(388)]) in eighteen GC patients, because the presence of at least one Arg(388) allele has been suggested to favor tumor cell motility compared to tumor cells homozygeous for the Gly(388) allele.	Arginine	126-129	fibroblast growth factor receptor 4	Homo sapiens	87-92
11513095-6	2001	The activity of bovine brain glyoxalase I was found to be particularly sensitive to 2,3-butanedione and diethylpyrocarbonate, selective reagents for arginine and histidine residues, respectively.	Arginine	149-157	glyoxalase I	Bos taurus	29-41
15942586-11	2005	Addition of L-arginine restored the angiogenic effect of vascular endothelial growth factor (ratios: 1.13 [rest] and 1.20 [pace]; P &lt; .05) and was associated with increased endothelial cell density, as well as vascular endothelial growth factor, endothelial nitric oxide synthase, and Akt protein levels in the ischemic territory.	Arginine	12-22	nitric oxide synthase 3	Sus scrofa	249-282
15946220-8	2005	Therefore, we constructed, expressed and characterized a TAFI mutant in which Ile182 and Ile183 were changed into the residues found in pancreas carboxypeptidase B at corresponding positions, Arg and Glu.	Arginine	192-195	carboxypeptidase B2	Homo sapiens	57-61
15939022-3	2005	In vivo assays with LOX-1 mutants revealed that the "basic spine," consisting of linearly aligned arginine residues spanning over the dimer surface, is responsible for ligand binding.	Arginine	98-106	oxidized low density lipoprotein receptor 1	Homo sapiens	20-25
15716048-3	2005	We showed that, as well as spermidine transport, the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis, is decreased in human colon adenocarcinoma cells, Caco-2, following a 4-h supplementation with one of the two polyamine precursor amino acids, L-arginine or L-methionine.	Arginine	301-311	ornithine decarboxylase 1	Homo sapiens	65-88
15716048-3	2005	We showed that, as well as spermidine transport, the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis, is decreased in human colon adenocarcinoma cells, Caco-2, following a 4-h supplementation with one of the two polyamine precursor amino acids, L-arginine or L-methionine.	Arginine	301-311	ornithine decarboxylase 1	Homo sapiens	90-93
15802136-0	2005	Development of a fast kinetic method for the determination of carboxypeptidase U (TAFIa) using C-terminal arginine containing peptides as substrate.	Arginine	106-114	carboxypeptidase B2	Homo sapiens	62-80
15802136-4	2005	We developed a fast kinetic assay for measuring continuously the release of the C-terminal arginine by CPU independent of the nature of the substrate peptide used, allowing us to perform substrate specificity studies of CPU.	Arginine	91-99	carboxypeptidase B2	Homo sapiens	103-106
15802136-4	2005	We developed a fast kinetic assay for measuring continuously the release of the C-terminal arginine by CPU independent of the nature of the substrate peptide used, allowing us to perform substrate specificity studies of CPU.	Arginine	91-99	carboxypeptidase B2	Homo sapiens	220-223
15802136-8	2005	The presented kinetic assay enables the fast screening of substrates with a C-terminal arginine and is a valuable new tool for the kinetic evaluation of both synthetic and physiological substrates of CPU.	Arginine	87-95	carboxypeptidase B2	Homo sapiens	200-203
16080486-2	2005	SULT1A1 activity varies among individuals, and this difference in phenotype is, in part, controlled by genetic polymorphism (Arg--&gt;His in codon 213).	Arginine	125-128	sulfotransferase family 1A member 1	Homo sapiens	0-7
15828837-2	2005	Previous studies showed that (111)In-DOTA-ReCCMSH(Arg(11)), a cyclic analogue of alpha-melanocyte stimulating hormone (alpha-MSH), exhibited high tumor concentration and rapid clearance from nontarget tissue.	Arginine	50-53	pro-opiomelanocortin-alpha	Mus musculus	81-117
15828837-2	2005	Previous studies showed that (111)In-DOTA-ReCCMSH(Arg(11)), a cyclic analogue of alpha-melanocyte stimulating hormone (alpha-MSH), exhibited high tumor concentration and rapid clearance from nontarget tissue.	Arginine	50-53	pro-opiomelanocortin-alpha	Mus musculus	119-128
15823041-0	2005	Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes.	Arginine	37-45	H2A clustered histone 18	Homo sapiens	23-33
15695825-7	2005	We find that the three arginines that anchor phosphothreonine 160 of fully active CDK2 do not contribute equally to structural stabilization.	Arginine	23-32	cyclin dependent kinase 2	Homo sapiens	82-86
15748708-6	2005	As the concentration of L-arginine and N(omega)-hydroxyl-L-arginine increases, the rate of NADPH consumption for H(4)B-bound NOS1 decreased resulting in lower rates of both O(2)(*-) and H(2)O(2) generation, while increasing the rate of nitric oxide (*NO) production.	Arginine	24-34	nitric oxide synthase 1	Homo sapiens	125-129
15748708-7	2005	At saturating concentrations of L-arginine or N(omega)-hydroxyl-L-arginine (50microM), NOS1 still produced O(2)(*-) and H(2)O(2).	Arginine	32-42	nitric oxide synthase 1	Homo sapiens	87-91
15781655-5	2005	Such properties can be explained by taking into consideration the composition of class III beta-tubulin paclitaxel binding site; in fact, Ser277 interacting with paclitaxel C group in class I is replaced by an Arginine in class III.	Arginine	210-218	tubulin beta 3 class III	Homo sapiens	81-103
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	LHFPL tetraspan subfamily member 5	Homo sapiens	126-130
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	LHFPL tetraspan subfamily member 5	Homo sapiens	158-162
15574418-2	2005	Under conditions of L-arginine or tetrahydrobiopterin (BH(4)) depletion, nNOS also generates superoxide, O(2)(.	Arginine	20-30	nitric oxide synthase 1	Homo sapiens	73-77
11804685-3	2002	There is a G--&gt;A nucleotide polymorphism in SULT1A1 gene that codes for an Arg--&gt;His substitution, which results in decreased activity and thermal stability of the SULT1A1 enzyme.	Arginine	78-81	sulfotransferase family 1A member 1	Homo sapiens	47-54
11804685-3	2002	There is a G--&gt;A nucleotide polymorphism in SULT1A1 gene that codes for an Arg--&gt;His substitution, which results in decreased activity and thermal stability of the SULT1A1 enzyme.	Arginine	78-81	sulfotransferase family 1A member 1	Homo sapiens	170-177
15574418-6	2005	production from nNOS under conditions of L-arginine and/or BH(4) depletion, using electron paramagnetic resonance spin trapping.	Arginine	41-51	nitric oxide synthase 1	Homo sapiens	16-20
15740668-11	2005	A mutation of C to T was detected by sequencing at the nucleotide 1080 that converts the Arg codon (CGA) to the termination codon (TGA).	Arginine	89-92	T-box transcription factor 1	Homo sapiens	131-134
11711547-2	2002	We have shown that not only Tat-(48-60) but many arginine-rich peptides, including HIV-1 Rev-(34-50) and octaarginine (Arg(8)), efficiently translocated through the cell membranes and worked as protein carriers (Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., and Sugiura, Y.	Arginine	49-57	Rev	Human immunodeficiency virus 1	89-92
11711547-2	2002	We have shown that not only Tat-(48-60) but many arginine-rich peptides, including HIV-1 Rev-(34-50) and octaarginine (Arg(8)), efficiently translocated through the cell membranes and worked as protein carriers (Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., and Sugiura, Y.	Arginine	119-122	Rev	Human immunodeficiency virus 1	89-92
15572352-4	2005	A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3).	Arginine	48-56	Vba2p	Saccharomyces cerevisiae S288C	129-133
11711547-6	2002	Quantification and time course analyses of the cellular uptake of the above peptides by mouse macrophage RAW264.7, human cervical carcinoma HeLa, and simian kidney COS-7 cells revealed that Rev-(34-50) and Arg(8) had a comparable translocation efficiency to Tat-(48-60).	Arginine	206-209	Rev	Human immunodeficiency virus 1	190-193
15572352-4	2005	A defect in the uptake of histidine, lysine, or arginine was also observed in the vacuolar membrane vesicles of mutants YBR293w (VBA2) and YCL069w (VBA3).	Arginine	48-56	basic amino acid transporter	Saccharomyces cerevisiae S288C	148-152
11790133-1	2002	The conserved residues, Arg-349 and Asp-373, of the renal Na(+)/dicarboxylate cotransporter (NaDC-1) have been shown in our previous studies to affect substrate affinity and cation binding.	Arginine	24-27	solute carrier family 13 member 2	Homo sapiens	93-99
15660961-7	2005	Co-treatment of animals with nifedipine and L-arginine protected from gingival hyperplasia and retained flow rate, and concentrations of total protein, EGF and calcium in normal levels.	Arginine	44-54	epidermal growth factor like 1	Rattus norvegicus	152-155
11781091-5	2002	Mutation of two conserved arginine residues in the NSF-D1 SRH (R385A and R388A) did not effect basal or soluble NSF attachment protein (SNAP)-stimulated ATPase activity; however, neither mutant underwent ATP-dependent release from SNAP-SNARE complexes.	Arginine	26-34	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	51-54
15656624-2	2005	Thus, arginine-containing peptides as Tat or Antp, oligoarginine peptides, and derived peptoids have been described as shuttles for delivering nonpermeant drugs inside cancer cells.	Arginine	6-14	tyrosine aminotransferase	Homo sapiens	38-41
12378270-0	2002	Methylation of the arginine-glycine-rich region in the fragile X mental retardation protein FMRP differentially affects RNA binding.	Arginine	19-27	nuclear FMR1 interacting protein 2	Homo sapiens	92-96
12053127-4	2002	In one allele, an arginine insertion at codon 352 in the presenilin 1 (PSEN1) gene was identified; no mutation was identified in the amyloid precursor protein or tau genes.	Arginine	18-26	presenilin 1	Homo sapiens	57-69
15596135-8	2005	A fluorogenically quenched synthetic peptide encompassing Arg(761) of the spike glycoprotein was efficiently cleaved by furin and the cleavage was inhibited by EDTA and dec-RVKR-cmk.	Arginine	58-61	furin, paired basic amino acid cleaving enzyme	Homo sapiens	120-125
12053127-4	2002	In one allele, an arginine insertion at codon 352 in the presenilin 1 (PSEN1) gene was identified; no mutation was identified in the amyloid precursor protein or tau genes.	Arginine	18-26	presenilin 1	Homo sapiens	71-76
11860506-7	2002	The study shows that desensitization and resensitization kinetics of homomeric GluR2 flop channels are controlled by a single amino acid exchange (glycine by arginine) at the R/G site.	Arginine	158-166	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	79-84
11352902-9	2001	These results suggest that Arg(49) and Asp(50) may be targeted for the design of potent and selective inhibitors of TCPTP and PTP1B.	Arginine	27-30	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	116-121
11369771-1	2001	Cleavage of Arg(561)-Val(562) in plasminogen (Pg) generates plasmin (Pm) through a classical activation mechanism triggered by an insertion of the new amino terminus into a binding pocket in the Pg catalytic domain.	Arginine	12-15	plasminogen	Homo sapiens	33-40
15609295-6	2005	DNA sequencing analysis showed the patient to be a compound heterozygote for two mutations in the GPIX gene, a novel nine-nucleotide deletion starting at position 1952 of the gene that changes asparagine 86 for alanine and eliminates amino acids 87, 88, and 89 (arginine, threonine, and proline) and a previously reported point mutation that changes the codon asparagine (AAC) for serine (AGC) at residue 45.	Arginine	262-270	glycoprotein IX platelet	Homo sapiens	98-102
11401991-2	2001	The aim of this study was to investigate the effect of the arginine-specific cysteine protease gingipain-R produced by P. gingivalis on chemokine production by human gingival fibroblasts (HGF) and the effect of gingipain-R treatment on the subsequent contact-dependent activation of HGF by T cells.	Arginine	59-67	hepatocyte growth factor	Homo sapiens	188-191
11401991-2	2001	The aim of this study was to investigate the effect of the arginine-specific cysteine protease gingipain-R produced by P. gingivalis on chemokine production by human gingival fibroblasts (HGF) and the effect of gingipain-R treatment on the subsequent contact-dependent activation of HGF by T cells.	Arginine	59-67	hepatocyte growth factor	Homo sapiens	283-286
11434650-9	2001	RESULTS: In the pilot study, ARG reduced the SBP in HD patients from 171.5 +/- 7.5 mmHg (baseline) to 142.8 +/- 8.3 mmHg (p = .028).	Arginine	29-32	selenium binding protein 1	Homo sapiens	45-48
11434650-14	2001	CONCLUSIONS: Oral preparations of ARG (+/-CanO) were well tolerated for up to 60 consecutive days and had favorable effects on SBP and DBP in hypertensive KT and HD patients.	Arginine	34-37	selenium binding protein 1	Homo sapiens	127-130
11408616-6	2001	The blockade of CYP2B1 down-regulation by NO synthase inhibitors was reversed by arginine, and the NO donors S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine mimicked CYP2B1 protein suppression.	Arginine	81-89	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	16-22
11406294-2	2001	Cellular NO production depends absolutely on the availability of arginine, a substrate of NO synthase (NOS).	Arginine	65-73	nitric oxide synthase 1, neuronal	Mus musculus	90-101
11399772-8	2001	Specificity for the amidated disulfide cofactor partly can be explained by the substitution of Arg-37, shown by x-ray crystallographic data of the human glutathione reductase to hydrogen-bond one of the glutathione glycyl carboxylates, by the negatively charged Glu-21.	Arginine	95-98	glutathione-disulfide reductase	Homo sapiens	153-174
11439928-10	2001	Additional hIK1/rSK2 chimeras defined the minimal region of hIK1 required to confer complete ATP sensitivity as including amino acids Arg(355)-Ala(413).	Arginine	134-137	potassium calcium-activated channel subfamily N member 4	Homo sapiens	60-64
11439928-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 4	Homo sapiens	63-67
11439928-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 4	Homo sapiens	186-190
11439928-13	2001	These results demonstrate that amino acids Arg(355)-Ala(413) within the C terminus of hIK1 confer sensitivity to ATP.	Arginine	43-46	potassium calcium-activated channel subfamily N member 4	Homo sapiens	86-90
11333913-2	2001	The complete open reading frame, with alanine, arginine, and glutamine at susceptibility codons 136, 154, and 171, respectively, was inserted downstream from the neuron-specific enolase promoter.	Arginine	47-55	enolase 2, gamma neuronal	Mus musculus	162-185
11371193-1	2001	The channel constriction of OmpF porin, a pore protein in the bacterial outer membrane, is highly charged due to the presence of three arginines (R42, R82, and R132) and two acidic residues (D113 and E117).	Arginine	135-144	voltage dependent anion channel 1	Homo sapiens	33-38
11371635-9	2001	We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP.	Arginine	56-64	RAS p21 protein activator 1	Homo sapiens	93-100
11371635-9	2001	We find that the carbonyl oxygen on the backbone of the arginine finger supplied in trans by p120GAP (Arg-789) interacts with a water molecule in the active site that is forming a bridge between the NH(2) group of the Gln-61 and the gamma-phosphate of GTP.	Arginine	102-105	RAS p21 protein activator 1	Homo sapiens	93-100
11336641-4	2001	Both nitrocatecholamines antagonized the dimerization of nNOS induced by BH(4) and by L-arginine, the effect being reversed by BH(4) (more than 10 microM) and L-arginine (e.g. 100 microM).	Arginine	86-96	nitric oxide synthase 1	Homo sapiens	57-61
11336641-4	2001	Both nitrocatecholamines antagonized the dimerization of nNOS induced by BH(4) and by L-arginine, the effect being reversed by BH(4) (more than 10 microM) and L-arginine (e.g. 100 microM).	Arginine	159-169	nitric oxide synthase 1	Homo sapiens	57-61
11331007-2	2001	Both catalytic sites are comprised of two histidine side chains acting as a general base-general acid pair and a phosphate-activating residue: an arginine in the case of PI-PLC and a lysine in RNase A.	Arginine	146-154	phospholipase C beta 1	Homo sapiens	170-176
11331007-4	2001	Here, we report a systematic study of this property in PI-PLC, conducted by means of site-directed chemical modification of a cysteine residue replacing the arginine at position 69.	Arginine	157-165	phospholipase C beta 1	Homo sapiens	55-61
11389857-2	2001	SMN binds the arginine- and glycine-rich (RG) domains of the snRNP proteins SmD1 and SmD3.	Arginine	14-22	survival of motor neuron 1, telomeric	Homo sapiens	0-3
11389857-2	2001	SMN binds the arginine- and glycine-rich (RG) domains of the snRNP proteins SmD1 and SmD3.	Arginine	14-22	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	85-89
11389857-6	2001	Thus, methylation of arginines is a novel mechanism to promote specific protein-protein interactions and appears to be key to generating high-affinity SMN substrates.	Arginine	21-30	survival of motor neuron 1, telomeric	Homo sapiens	151-154
11278907-3	2001	Substitution with alanine of several arginines, which Gyp6p shares with other GYP family members, resulted in significant inhibition of GAP activity.	Arginine	37-46	GTPase-activating protein GYP6	Saccharomyces cerevisiae S288C	54-59
11152681-5	2001	Myelin basic protein methylated by PRMT5 contained monomethylated and dimethylated arginine residues.	Arginine	83-91	myelin basic protein	Homo sapiens	0-20
11292369-0	2001	Modulation of cerebellar and hepatic nitric oxide synthase by exogenous arginine and endotoxin.	Arginine	72-80	nitric oxide synthase 1, neuronal	Mus musculus	37-58
11237702-1	2001	Nitric oxide (NO) is synthesized from l-Arg via N(G)-hydroxyl-l-Arg (NHA) in the heme active site of nitric oxide synthase (NOS).	Arginine	38-43	nitric oxide synthase 1	Homo sapiens	101-122
11237702-2	2001	According to the crystal structure of other NOS isoforms, the carboxylate group of l-Arg hydrogen bonds to the hydroxyl group of the conserved Tyr588 residue in the heme distal site of neuronal NOS (nNOS).	Arginine	83-88	nitric oxide synthase 1	Homo sapiens	185-197
11237702-2	2001	According to the crystal structure of other NOS isoforms, the carboxylate group of l-Arg hydrogen bonds to the hydroxyl group of the conserved Tyr588 residue in the heme distal site of neuronal NOS (nNOS).	Arginine	83-88	nitric oxide synthase 1	Homo sapiens	199-203
11237702-3	2001	Indeed, the nNOS mutations Tyr588His, Tyr588Ser, and Tyr588Phe markedly increased the dissociation constants for l-Arg and NHA by 2.2-8.2-fold and 1.5-3.9-fold, respectively.	Arginine	113-118	nitric oxide synthase 1	Homo sapiens	12-16
11263835-1	2001	Thirty-nine adult light horse mares, geldings, and stallions were used in two experiments to assess the pituitary hormone and insulin responses to infusions of arginine, aspartic acid, lysine, glutamic acid, and N-methyl-D,L-aspartate (NMA).	Arginine	160-168	INS	Equus caballus	126-133
11263835-8	2001	In contrast, acute release of prolactin (P = 0.001) and insulin (P = 0.002) was induced only by arginine; moreover, the arginine effect on insulin was present only in mares (P = 0.011).	Arginine	96-104	INS	Equus caballus	56-63
11263835-8	2001	In contrast, acute release of prolactin (P = 0.001) and insulin (P = 0.002) was induced only by arginine; moreover, the arginine effect on insulin was present only in mares (P = 0.011).	Arginine	120-128	INS	Equus caballus	139-146
11263835-14	2001	In the horse, aspartic acid, glutamic acid, and NMA seem to stimulate GH release; arginine and lysine seem to stimulate prolactin and insulin release; and NMA seems to stimulate LH and FSH release.	Arginine	82-90	INS	Equus caballus	134-141
11851195-18	2001	The striking benefit observed when TPN containing high BCAA and high ARG was infused may be due to the high BCAA leading toward normalization of serum amino acid levels, reducing proteolysis, increasing protein synthesis, and accelerating early liver regeneration, combined with the high ARG likely reducing serum ammonia and leading to increased host defense, and perhaps, thereby, preventing bacterial translocation and bacteremia.	Arginine	69-72	AT-rich interaction domain 4B	Rattus norvegicus	108-112
11851195-18	2001	The striking benefit observed when TPN containing high BCAA and high ARG was infused may be due to the high BCAA leading toward normalization of serum amino acid levels, reducing proteolysis, increasing protein synthesis, and accelerating early liver regeneration, combined with the high ARG likely reducing serum ammonia and leading to increased host defense, and perhaps, thereby, preventing bacterial translocation and bacteremia.	Arginine	288-291	AT-rich interaction domain 4B	Rattus norvegicus	55-59
11851195-18	2001	The striking benefit observed when TPN containing high BCAA and high ARG was infused may be due to the high BCAA leading toward normalization of serum amino acid levels, reducing proteolysis, increasing protein synthesis, and accelerating early liver regeneration, combined with the high ARG likely reducing serum ammonia and leading to increased host defense, and perhaps, thereby, preventing bacterial translocation and bacteremia.	Arginine	288-291	AT-rich interaction domain 4B	Rattus norvegicus	108-112
28095235-1	2001	To explain the insurmountable/long-lasting binding of biphenyltetrazole-containing AT1-receptor antagonists such as candesartan, to the human angiotensin II type 1-receptor, a model is proposed in which the basic amino acids Lys199 and Arg 167 of the receptor interact respectively with the carboxylate and the tetrazole group of the antagonists.	Arginine	236-239	angiotensin II receptor type 1	Homo sapiens	142-172
11900275-7	2002	RESULTS: A significant enrichment in DQB1 alleles encoding for an amino acid different from Asp in position 57 (NA) and DQA1 alleles encoding for Arg in position 52 was observed in diabetic subjects and first-degree relatives as compared to controls.	Arginine	146-149	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	120-124
11939578-0	2002	Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Pro-carboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), precursor of carboxypeptidase U and plasma carboxypeptidase B is present in plasma and following activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a.	Arginine	347-355	carboxypeptidase B2	Homo sapiens	44-62
11939578-0	2002	Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Pro-carboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), precursor of carboxypeptidase U and plasma carboxypeptidase B is present in plasma and following activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a.	Arginine	347-355	carboxypeptidase B2	Homo sapiens	91-109
11939578-0	2002	Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Pro-carboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), precursor of carboxypeptidase U and plasma carboxypeptidase B is present in plasma and following activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a.	Arginine	347-355	carboxypeptidase B2	Homo sapiens	134-177
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Arginine	104-112	carboxypeptidase B2	Homo sapiens	29-47
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Arginine	104-112	carboxypeptidase B2	Homo sapiens	49-52
12140778-2	2002	Neuronal NO is widely produced in the brain from L-arginine catalyzed by neuronal NO synthase (NOS1).	Arginine	49-59	nitric oxide synthase 1	Homo sapiens	95-99
12469900-7	2002	Furthermore, the Arg-Gly-Asp-Ser(RGDS)-peptide effectively inhibited collagen-triggered aggregation and CL, and the subsequent enhancement of the fMet-Leu-Phe-induced responses.	Arginine	17-20	ral guanine nucleotide dissociation stimulator	Homo sapiens	33-37
11598120-2	2001	In the insulin receptor"s kinase domain, Asp-1161 and Tyr-1162 in the peptide substrate-like sequence of the unphosphorylated activation loop can interact with four invariant residues in the active site: Lys-1085, Asp-1132, Arg-1136, and Gln-1208.	Arginine	224-227	insulin receptor	Homo sapiens	7-23
11744064-1	2001	Nitric oxide (NO) is synthesized from L-Arg in the P450-type heme active site of nitric-oxide synthase (NOS).	Arginine	38-43	nitric oxide synthase 1	Homo sapiens	81-102
11567024-4	2001	In an EST data base search for cDNAs homologous to MM-1, we found a frequent substitution of amino acid 157 of MM-1, from alanine to arginine (A157R), and the substitution was observed more in tumor cells than in normal cells.	Arginine	133-141	prefoldin subunit 5	Homo sapiens	51-55
11567024-4	2001	In an EST data base search for cDNAs homologous to MM-1, we found a frequent substitution of amino acid 157 of MM-1, from alanine to arginine (A157R), and the substitution was observed more in tumor cells than in normal cells.	Arginine	133-141	prefoldin subunit 5	Homo sapiens	111-115
11696014-1	2001	When l-arginine is depleted, neuronal nitric oxide synthase (nNOS) has been reported to generate superoxide.	Arginine	5-15	nitric oxide synthase 1	Homo sapiens	29-59
11696014-1	2001	When l-arginine is depleted, neuronal nitric oxide synthase (nNOS) has been reported to generate superoxide.	Arginine	5-15	nitric oxide synthase 1	Homo sapiens	61-65
11675497-5	2001	Sequence analysis of CD40 genomic DNA showed that one patient carried a homozygous silent mutation at the fifth base pair position of exon 5, involving an exonic splicing enhancer and leading to exon skipping and premature termination; the other two patients showed a homozygous point mutation in exon 3, resulting in a cysteine to arginine substitution.	Arginine	332-340	CD40 molecule	Homo sapiens	21-25
11479287-0	2001	The contribution of arginine residues within the P6-P1 region of alpha 1-antitrypsin to its reaction with furin.	Arginine	20-28	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
11517452-1	2001	Arginine (Arg), injected intraperitoneally into rainbow trout (Oncorhynchus mykiss), increases plasma concentrations of glucagon, glucagon-like peptide-1 (GLP-1), and insulin by three- to 10-fold.	Arginine	0-8	glucagon like peptide 1 receptor	Homo sapiens	155-160
11517452-1	2001	Arginine (Arg), injected intraperitoneally into rainbow trout (Oncorhynchus mykiss), increases plasma concentrations of glucagon, glucagon-like peptide-1 (GLP-1), and insulin by three- to 10-fold.	Arginine	0-3	glucagon like peptide 1 receptor	Homo sapiens	155-160
11517452-7	2001	Hepatocytes isolated from feeding fish injected with Arg 2 h previously show significantly lower rates of lactate oxidation than controls (85% of control), while rates of gluconeogenesis and hormonal responses to mammalian glucagon and GLP-1 remain unchanged.	Arginine	53-56	glucagon like peptide 1 receptor	Homo sapiens	236-241
11402053-4	2001	Most strikingly, these studies have identified Arg-513 as a critical determinant in the ability of COX-2 to efficiently generate prostaglandin H(2) glycerol ester, explaining, in part, the observed isoform selectivity for this substrate.	Arginine	47-50	cytochrome c oxidase II, mitochondrial	Mus musculus	99-104
11402053-5	2001	Mutational analysis of Leu-531, an amino acid located directly across from Arg-513 in the COX-2 active site, suggests that 2-AG is shifted in the active site away from this hydrophobic residue and toward Arg-513 relative to arachidonic acid.	Arginine	75-78	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
11402053-5	2001	Mutational analysis of Leu-531, an amino acid located directly across from Arg-513 in the COX-2 active site, suggests that 2-AG is shifted in the active site away from this hydrophobic residue and toward Arg-513 relative to arachidonic acid.	Arginine	204-207	cytochrome c oxidase II, mitochondrial	Mus musculus	90-95
11470490-11	2001	Results from in vitro phosphorylation indicate that the absence of arginines 362 and 376 completely abolishes phosphorylation in the connexin43 channel regulation domain suggesting a possible mechanism for the pathologies associated with HLHS.	Arginine	67-76	gap junction protein alpha 1	Homo sapiens	133-143
11387442-5	2001	Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300.	Arginine	15-18	E1A binding protein p300	Homo sapiens	80-84
11470762-0	2001	Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.	Arginine	8-16	glutathione S-transferase, alpha 2 (Yc2)	Mus musculus	103-109
11454802-8	2001	A lower dose of arginine (3.0 g/kg) induced less pancreatitis but a larger increase in HSP70 and HSP27 expression and phosphorylation of HSP27.	Arginine	16-24	heat shock protein family B (small) member 1	Rattus norvegicus	97-102
11454802-8	2001	A lower dose of arginine (3.0 g/kg) induced less pancreatitis but a larger increase in HSP70 and HSP27 expression and phosphorylation of HSP27.	Arginine	16-24	heat shock protein family B (small) member 1	Rattus norvegicus	137-142
11481035-1	2001	Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to citrulline and nitric oxide through two stepwise oxygenation reactions involving N(omega)-hydroxy-L-arginine, an enzyme-bound intermediate.	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	0-21
11463460-1	2001	The primary S(1) subsite specificity of a recombinant cysteine proteinase, CPB2.8 Delta CTE, of Leishmania mexicana was investigated in a systematic way using a series of peptides derived from Abz-KLRFSKQ-EDDnp in which Arg was substituted by all natural amino acids (where Abz is ortho-amino-benzoyl and EDDnp is N-[2,4-dinitrophenyl]-ethylenediamine).	Arginine	220-223	carboxypeptidase B2	Homo sapiens	75-79
11418470-11	2001	RGDS (Arg-Gly-Asp-Ser) or antibodies to alpha5beta1 or alphaIIbbeta3 integrins caused a partial decrease in LPA-induced deposition of FITC-FN.	Arginine	6-9	ral guanine nucleotide dissociation stimulator	Homo sapiens	0-4
11410740-6	2001	RESULTS: The L-arginine transport system functioning in the hepatic stellate cells was system y+, possibly mediated by CAT-1 and CAT-2B (Km approximately 50 microM).	Arginine	13-23	solute carrier family 7 member 1	Rattus norvegicus	119-124
11278612-11	2001	In terms of specific PKC isoforms, our results suggest that the presence of Arg-20 in PKC-zeta may contribute to its lack of phorbol ester binding activity.	Arginine	76-79	protein kinase C delta	Homo sapiens	21-24
11408592-2	2001	The MAL carboxy terminus ends with the sequence Arg-Trp-Lys-Ser-Ser (RWKSS), which resembles dilysine-based motifs involved in protein sorting.	Arginine	48-51	mal, T cell differentiation protein	Canis lupus familiaris	4-7
11339812-3	2001	Arginine 91 is an important residue in binding the FAD prosthetic group and part of a conserved "RxY(T)(S)xx(S)(N)" sequence motif that is omnipresent in the "ferredoxin:NADP(+) reductase" family of flavoproteins.	Arginine	0-8	ferredoxin reductase	Homo sapiens	159-187
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	173-176	glutamate metabotropic receptor 1	Homo sapiens	17-23
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	173-176	glutamate metabotropic receptor 1	Homo sapiens	32-38
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	177-180	glutamate metabotropic receptor 1	Homo sapiens	17-23
11170182-5	2001	Pretreatment with Gly-Arg-Gly-Asp-Ser peptide inhibited the SSC increasing action of 12-o-tetradecanoyl-phorbol-13-acetate (TPA, 0.5 microM) plus fibronectin, but not that of TPA plus laminin.	Arginine	22-25	fibronectin 1 S homeolog	Xenopus laevis	146-157
11312916-2	2001	The binding of fibrinogen to the fibrinogen receptor depends on an Arg-Gly-Asp-Ser (RGDS) tetrapeptide recognition motif.	Arginine	67-70	ral guanine nucleotide dissociation stimulator	Homo sapiens	84-88
15740521-1	2005	BACKGROUND: To evaluate whether L-Arginine has an effect on endogenous epidermal growth factor secretion and intestinal adaptation in massive small bowel resection an experimental study was performed.	Arginine	32-42	epidermal growth factor like 1	Rattus norvegicus	71-94
11096085-13	2001	These results demonstrate that amino acids Arg(355)-Ala(413) within the C terminus of hIK1 confer sensitivity to ATP.	Arginine	43-46	potassium calcium-activated channel subfamily N member 4	Homo sapiens	86-90
11337935-2	2001	Recently, a polymorphism of the beta 1-adrenoceptor has been detected: at amino acid position 389 either Gly or Arg has been found with the Gly389 exhibiting reduced responsiveness upon agonist-induced stimulation in vitro.	Arginine	112-115	adrenoceptor beta 1	Homo sapiens	32-51
11219777-2	2001	A G---&gt;A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene was reported recently, and individuals homozygous for the His allele have a substantially lower activity of this enzyme than those with other genotypes.	Arginine	41-44	sulfotransferase family 1A member 1	Homo sapiens	64-71
11240372-3	2001	In the presence of glycerol, L-arginine and/or tetrahydrobiopterin, the sodium cholate-treated P-420 form could be reconverted to the P-450 form under constant experimental conditions, and the nNOS activity could also be restored.	Arginine	29-39	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	134-139
11240372-3	2001	In the presence of glycerol, L-arginine and/or tetrahydrobiopterin, the sodium cholate-treated P-420 form could be reconverted to the P-450 form under constant experimental conditions, and the nNOS activity could also be restored.	Arginine	29-39	nitric oxide synthase 1	Homo sapiens	193-197
11240372-8	2001	After removing the urea by dialysis, and supplementation of the nNOS solution with glycerol, L-arginine or BH(4), the P-420 was reconverted to the P-450 form, and the reassociation of nNOS monomers was also observed.	Arginine	93-103	nitric oxide synthase 1	Homo sapiens	64-68
15740521-14	2005	The high levels of epidermal growth factor in body fluids of L-Arginine treated rats could be the explanation for this effect.	Arginine	61-71	epidermal growth factor like 1	Rattus norvegicus	19-42
15611636-3	2005	SUMO-1 attachment targets DeltaNp63alpha for proteasome mediated degradation while it does not influence p63alpha intracellular localization, as wild-type protein and a mutant carring the K637 mutated into arginine (K637R), have the same nuclear localization.	Arginine	206-214	small ubiquitin like modifier 1	Homo sapiens	0-6
11173525-5	2001	The deduced amino acid sequence of the V(H) chain-CDR3 region of 2A3 was RRYALDY, of which the Arg residues at positions 1 and 2 of the CDR3 region were observed to be extremely rare in other antibodies by homology analysis.	Arginine	95-98	CDR3	Homo sapiens	50-54
11173525-5	2001	The deduced amino acid sequence of the V(H) chain-CDR3 region of 2A3 was RRYALDY, of which the Arg residues at positions 1 and 2 of the CDR3 region were observed to be extremely rare in other antibodies by homology analysis.	Arginine	95-98	CDR3	Homo sapiens	136-140
11134025-5	2001	A distinct, Arg/Lys-rich N-terminal region targets CKA1 to the cell periphery.	Arginine	12-15	Choline Kinase A	Caenorhabditis elegans	51-55
15638817-5	2005	RESULTS: After 3 weeks of treatment, values of SBP, DPB and MAP were significantly lower in the group taking l-arginine as compared with the placebo group (SBP: 134.2 +/- 2.9 vs. 143.1 +/- 2.8; DBP: 81.6 +/- 1.7 vs. 86.5 +/- 0.9; MAP: 101.8 +/- 1.5 vs. 108.0 +/- 1.2 mmHg, P &lt; 0.01).	Arginine	109-119	selenium binding protein 1	Homo sapiens	47-50
11053423-3	2001	Main interaction sites are centered around Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively.	Arginine	100-103	ferredoxin reductase	Homo sapiens	145-147
15638817-5	2005	RESULTS: After 3 weeks of treatment, values of SBP, DPB and MAP were significantly lower in the group taking l-arginine as compared with the placebo group (SBP: 134.2 +/- 2.9 vs. 143.1 +/- 2.8; DBP: 81.6 +/- 1.7 vs. 86.5 +/- 0.9; MAP: 101.8 +/- 1.5 vs. 108.0 +/- 1.2 mmHg, P &lt; 0.01).	Arginine	109-119	selenium binding protein 1	Homo sapiens	156-159
11798852-7	2001	It changed the codon CGA for Arginine to a terminator codon TGA and causes retinitis pigmentosa in the two families.	Arginine	29-37	T-box transcription factor 1	Homo sapiens	60-63
11069906-5	2001	By chemical modification and NMR structure of ILBP, arginine residue 122 was identified as the probable contact point for the negatively charged side chain of cholyltaurine.	Arginine	52-60	gastrotropin	Oryctolagus cuniculus	46-50
16370491-0	2005	The IVS-II-1 (G--&gt;a) beta0-thalassemia mutation in cis with HbA2-Troodos [delta116(G18)Arg--&gt;Cys (CGC--&gt;TGC)] causes a complex prenatal diagnosis in an Iranian family.	Arginine	90-93	hemoglobin subunit alpha 2	Homo sapiens	63-67
15471871-0	2004	Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.	Arginine	64-72	nuclear receptor subfamily 1 group H member 4	Homo sapiens	35-55
11104775-7	2001	The most important residue in the KIM sequence of MKP3 is Arg(65), which probably interacts with Asp(319) in ERK2.	Arginine	58-61	dual specificity phosphatase 6	Homo sapiens	50-54
11905149-7	2001	Systemic NO synthase inhibition partially reversed these effects of L-Arginine.	Arginine	68-78	nitric oxide synthase, brain	Oryctolagus cuniculus	9-20
11222721-0	2001	Exchange of the basic domain of human immunodeficiency virus type 1 Rev for a polyarginine stretch expands the RNA binding specificity, and a minimal arginine cluster is required for optimal RRE RNA binding affinity, nuclear accumulation, and trans-activation.	Arginine	82-90	Rev	Human immunodeficiency virus 1	68-71
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	nuclear receptor subfamily 1 group H member 4	Homo sapiens	168-171
11222721-6	2001	A nine-arginine insertion outside of the natural context of the Rev nuclear localization signal domain was incompatible with activation of either RNA target.	Arginine	7-15	Rev	Human immunodeficiency virus 1	64-67
11305941-0	2001	Conservation of the binding site for the arginine repressor in all bacterial lineages.	Arginine	41-49	repressor	Escherichia coli	50-59
15471871-7	2004	Induction of endogenous BSEP mRNA and Arg-17 methylation by FXR regulatory element ligand, CDCA, requires CARM1 activity.	Arginine	38-41	nuclear receptor subfamily 1 group H member 4	Homo sapiens	60-63
11305941-3	2001	Thus, the arginine repressor is different from two other universal transcription factors - HrcA, whose recognition signal is very strongly conserved both within and between genomes, and LexA/DinR, whose signal is strongly conserved within, but not between, genomes.	Arginine	10-18	repressor	Escherichia coli	19-28
11305941-7	2001	Candidate arginine repressor binding sites were identified upstream of arginine transport and metabolism genes.	Arginine	10-18	repressor	Escherichia coli	19-28
11222740-0	2001	Insertional mutagenesis of the arginine cage domain of the gonadotropin-releasing hormone receptor.	Arginine	31-39	gonadotropin releasing hormone receptor	Homo sapiens	59-98
15471871-8	2004	Therefore, histone methylation at Arg-17 by CARM1 is a downstream target of signaling through ligand-mediated activation of FXR.	Arginine	34-37	nuclear receptor subfamily 1 group H member 4	Homo sapiens	124-127
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	177-180	glutamate metabotropic receptor 1	Homo sapiens	32-38
11305941-7	2001	Candidate arginine repressor binding sites were identified upstream of arginine transport and metabolism genes.	Arginine	71-79	repressor	Escherichia coli	19-28
15471876-4	2004	Although both human and B. subtilis enzymes normally have Asp at position 87 (or 69), the B. subtilis ASL has Ile and Asp at 62 and 65, respectively, whereas human ASL has Glu and Arg at the equivalent positions.	Arginine	180-183	adenylosuccinate lyase	Homo sapiens	164-167
11498731-4	2001	We investigated the association of a WRN gene polymorphism, namely c.4330 T --&gt; C leading to an amino acid substitution from Cys to Arg, with bone density and lumbar spondylosis score in unrelated Japanese postmenopausal women (n = 377).	Arginine	135-138	WRN RecQ like helicase	Homo sapiens	37-40
11190986-6	2001	RESULTS: L-Arginine at or greater than 100 micromol/L significantly enhanced anti-CD3 stimulated T lymphocyte proliferation (p = .01).	Arginine	9-19	CD3 antigen, epsilon polypeptide	Mus musculus	82-85
11190986-7	2001	L-Arginine was essential for adequate T lymphocyte (CD3+) cellular maturation (p = .01).	Arginine	0-10	CD3 antigen, epsilon polypeptide	Mus musculus	52-55
11170095-9	2001	Interestingly, all four EXT1 missense mutations occurred in an arginine residue at codon 340 (R340) that is known as a critical site for expression of heparan sulfate glycosaminoglycans, suggesting that the region encompassing the arginine residue may play an important role in the function of the EXT1 protein.	Arginine	63-71	exostosin glycosyltransferase 1	Homo sapiens	24-28
11170095-9	2001	Interestingly, all four EXT1 missense mutations occurred in an arginine residue at codon 340 (R340) that is known as a critical site for expression of heparan sulfate glycosaminoglycans, suggesting that the region encompassing the arginine residue may play an important role in the function of the EXT1 protein.	Arginine	231-239	exostosin glycosyltransferase 1	Homo sapiens	24-28
11190986-11	2001	In addition, the number of cell surface CD8 receptors (CD8R) and CD3 receptors (CD3R) increased in the presence of L-arginine (p = .01, p = .04).	Arginine	115-125	CD3 antigen, epsilon polypeptide	Mus musculus	65-68
15222879-6	2004	In the present study, we demonstrate that SMN binds to the arginine-rich N-terminus of FGF-2(23).	Arginine	59-67	survival of motor neuron 1, telomeric	Homo sapiens	42-45
11190986-15	2001	CONCLUSIONS: The requirements for L-arginine for the proliferation of CD3 stimulated T lymphocytes vary widely, and have to be taken into account when studying the mechanism of how L-arginine enhances cellular proliferation.	Arginine	34-44	CD3 antigen, epsilon polypeptide	Mus musculus	70-73
11190986-15	2001	CONCLUSIONS: The requirements for L-arginine for the proliferation of CD3 stimulated T lymphocytes vary widely, and have to be taken into account when studying the mechanism of how L-arginine enhances cellular proliferation.	Arginine	181-191	CD3 antigen, epsilon polypeptide	Mus musculus	70-73
15625443-8	2004	Deconvolution microscopy confirmed that glutamine and fructose preserved the actin cytoskeleton but there was disruption by arginine which correlated with F:G actin ratios and tissue ATP levels.	Arginine	124-132	ATPase phospholipid transporting 8A2	Homo sapiens	183-186
11766229-2	2001	NO is produced from L-arginine by three isoforms of nitric oxide synthase (NOS), neuronal (nNOS; NOS1), endothelial (eNOS; NOS3) and inducible (iNOS).	Arginine	20-30	nitric oxide synthase 1	Homo sapiens	52-73
11766229-2	2001	NO is produced from L-arginine by three isoforms of nitric oxide synthase (NOS), neuronal (nNOS; NOS1), endothelial (eNOS; NOS3) and inducible (iNOS).	Arginine	20-30	nitric oxide synthase 1	Homo sapiens	91-95
11342143-11	2001	Since liver does not express any of the previously known high-affinity cationic amino acid transporters, ATA3 is likely to provide the major route for the uptake of arginine in this tissue.	Arginine	165-173	solute carrier family 38 member 4	Homo sapiens	105-109
15625443-10	2004	CONCLUSION: Arginine resulted in worsened mucosal injury, disruption of the actin cytoskeleton, decreased tissue ATP and enhanced permeability compared with glutamine which appeared protective.	Arginine	12-20	ATPase phospholipid transporting 8A2	Homo sapiens	113-116
11160620-1	2001	Agmatine, a product of arginine decarboxylation in mammalian cells, is believed to govern cell polyamines by inducing antizyme, which in turn suppresses ornithine decarboxylase (ODC) activity and polyamine uptake.	Arginine	23-31	ornithine decarboxylase 1	Homo sapiens	153-176
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Arginine	72-75	solute carrier family 2 member 4	Homo sapiens	11-16
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Arginine	81-84	solute carrier family 2 member 4	Homo sapiens	11-16
10973972-7	2000	Efficient intracellular sorting and endocytosis of GLUT4 require an Arg pair between positions -4 and -7.	Arginine	68-71	solute carrier family 2 member 4	Homo sapiens	51-56
15452864-0	2004	L-arginine increases dopamine transporter activity in rat striatum via a nitric oxide synthase-dependent mechanism.	Arginine	0-10	solute carrier family 6 member 3	Rattus norvegicus	21-41
11113575-1	2000	Nitric oxide synthase (NOS) oxidizes L-arginine to NO(&amp;z.ccirf;) and L-citrulline.	Arginine	37-47	nitric oxide synthase 1	Homo sapiens	0-21
11160620-1	2001	Agmatine, a product of arginine decarboxylation in mammalian cells, is believed to govern cell polyamines by inducing antizyme, which in turn suppresses ornithine decarboxylase (ODC) activity and polyamine uptake.	Arginine	23-31	ornithine decarboxylase 1	Homo sapiens	178-181
15452864-2	2004	Rotating disk electrode voltammetry was used to measure dopamine (DA) transport in rat striatum to determine if 1) the nitric oxide synthase (NOS) substrate, L-arginine (L-Arg), could affect DAT activity; 2) L-Arg-dependent effects on DAT activity could be blocked by NOS and guanylate cyclase inhibitors, a NO scavenger, DA, and cocaine; 3) a NO donor could affect DAT activity; and 4) L-Arg could protect the DAT from a sulfhydryl agent.	Arginine	158-168	solute carrier family 6 member 3	Rattus norvegicus	191-194
11210879-2	2001	It is generated on demand by the enzyme nitric oxide synthase (NOS) on arginine.	Arginine	71-79	nitric oxide synthase, inducible	Cavia porcellus	40-61
15452864-3	2004	L-Arg increased DAT activity by increasing V(max).	Arginine	0-5	solute carrier family 6 member 3	Rattus norvegicus	16-19
15452864-7	2004	These results suggest that L-Arg, via NO, may play a role in regulating DAT activity in rat striatum by increasing the V(max) of DA transport.	Arginine	27-32	solute carrier family 6 member 3	Rattus norvegicus	72-75
11156380-6	2000	Using an RFLP that distinguishes an arginine to histidine change in exon 7 of the SULT1A1 gene, we characterized SULT1A1 genotypes in relation to breast cancer risk.	Arginine	36-44	sulfotransferase family 1A member 1	Homo sapiens	82-89
15452864-8	2004	Furthermore, it is suggested that the effects of L-Arg on DAT activity may be due to modification of the DAT itself, possibly via the NO-mediated modification of DAT cysteine residues.	Arginine	49-54	solute carrier family 6 member 3	Rattus norvegicus	58-61
15452864-8	2004	Furthermore, it is suggested that the effects of L-Arg on DAT activity may be due to modification of the DAT itself, possibly via the NO-mediated modification of DAT cysteine residues.	Arginine	49-54	solute carrier family 6 member 3	Rattus norvegicus	105-108
15452864-8	2004	Furthermore, it is suggested that the effects of L-Arg on DAT activity may be due to modification of the DAT itself, possibly via the NO-mediated modification of DAT cysteine residues.	Arginine	49-54	solute carrier family 6 member 3	Rattus norvegicus	105-108
11099312-3	2000	All three TCR exhibited N-nucleotide-determined Arg-Asp motifs in their CDR3-ss sequences.	Arginine	48-51	CDR3	Homo sapiens	72-76
15452864-9	2004	Finally, NO produced from L-Arg may affect the DAT differently than NO from NO donors.	Arginine	26-31	solute carrier family 6 member 3	Rattus norvegicus	47-50
15452864-10	2004	These results further the notion that dopaminergic neurotransmission may be regulated by changes in DAT activity caused by L-Arg and NOS.	Arginine	123-128	solute carrier family 6 member 3	Rattus norvegicus	100-103
10967110-6	2000	In a sensitized system where subthreshold amounts of a ventralizing Nck mutant were expressed, co-expression of the combination of Abl or Arg and Cbl at modest levels strongly potentiated anterior truncation, while Arg, Abl, or Cbl alone were without effect.	Arginine	138-141	Cbl proto-oncogene, E3 ubiquitin protein ligase L homeolog	Xenopus laevis	228-231
15364927-2	2004	Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction.	Arginine	156-159	death domain associated protein	Homo sapiens	41-45
15556994-2	2004	These homologous proteins differ at their N and C termini: the C-terminal Met-Leu-Leu in PLN is replaced by Arg-Ser-Tyr-Gln-Tyr in SLN.	Arginine	108-111	phospholamban	Homo sapiens	89-92
11054288-0	2000	Arginine side-chain dynamics in the HIV-1 rev-RRE complex.	Arginine	0-8	Rev	Human immunodeficiency virus 1	42-45
11054288-2	2000	To identify important features that influence the binding affinity and specificity of this Rev-RRE interaction, we have characterized the arginine side-chain dynamics of the Rev arginine-rich motif (ARM) while bound to a 34 nt RNA oligomer that corresponds to SLIIB.	Arginine	138-146	Rev	Human immunodeficiency virus 1	91-94
11054288-2	2000	To identify important features that influence the binding affinity and specificity of this Rev-RRE interaction, we have characterized the arginine side-chain dynamics of the Rev arginine-rich motif (ARM) while bound to a 34 nt RNA oligomer that corresponds to SLIIB.	Arginine	138-146	Rev	Human immunodeficiency virus 1	174-177
11054288-2	2000	To identify important features that influence the binding affinity and specificity of this Rev-RRE interaction, we have characterized the arginine side-chain dynamics of the Rev arginine-rich motif (ARM) while bound to a 34 nt RNA oligomer that corresponds to SLIIB.	Arginine	178-186	Rev	Human immunodeficiency virus 1	91-94
11054288-2	2000	To identify important features that influence the binding affinity and specificity of this Rev-RRE interaction, we have characterized the arginine side-chain dynamics of the Rev arginine-rich motif (ARM) while bound to a 34 nt RNA oligomer that corresponds to SLIIB.	Arginine	178-186	Rev	Human immunodeficiency virus 1	174-177
11054288-3	2000	As the specificity of the Rev-RRE interaction varies with salt concentration, arginine side-chain dynamics were characterized at two different salt conditions.	Arginine	78-86	Rev	Human immunodeficiency virus 1	26-29
15522297-4	2004	Purified MPP from potato processed two carrier proteins to an intermediate size, this processing was sensitive to an MPP inhibitor (1,10-phenanthroline) and further, processing could be inhibited by changing arginine residues to glycine residues at a -3 arginine consensus processing site for MPP.	Arginine	208-216	probable mitochondrial-processing peptidase subunit beta-like	Solanum tuberosum	9-12
11054288-7	2000	The observed dynamical behavior of the arginine side-chains at this protein-RNA interface likely plays an important role in the specificity and affinity of Rev-SLIIB complex formation.	Arginine	39-47	Rev	Human immunodeficiency virus 1	156-159
11054396-0	2000	Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis.	Arginine	67-77	nerve growth factor	Rattus norvegicus	0-19
11054396-3	2000	METHODS: NGF protein and messenger RNA (mRNA) levels in the pancreas were correlated with histopathologic changes during the course of acute necrotizing pancreatitis in rats induced by the intraperitoneal injection of L-arginine.	Arginine	218-228	nerve growth factor	Rattus norvegicus	9-12
15522297-4	2004	Purified MPP from potato processed two carrier proteins to an intermediate size, this processing was sensitive to an MPP inhibitor (1,10-phenanthroline) and further, processing could be inhibited by changing arginine residues to glycine residues at a -3 arginine consensus processing site for MPP.	Arginine	254-262	probable mitochondrial-processing peptidase subunit beta-like	Solanum tuberosum	9-12
15328354-7	2004	This is notably shown for the strictly conserved Arg-143 by site-directed mutagenesis on chloroplastic Cu,Zn-SOD.	Arginine	49-52	superoxide dismutase [Cu-Zn]	Bos taurus	103-112
11186266-0	2000	Hb Clinico-Madrid [alpha90(FG2)Lys-->Arg]: a new hemoglobin mutation in the alpha2-globin gene.	Arginine	37-40	hemoglobin subunit alpha 2	Homo sapiens	76-89
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Arginine	176-184	serine protease 8	Homo sapiens	74-83
11067864-4	2000	In these systems, the nitric oxide (NO) donors sodium nitroprusside (SNP) and NONOate and the NO synthase substrate L-arginine mimicked the effect of VP, stimulating relocation of AQP2 from cytoplasmic vesicles to the plasma membrane.	Arginine	116-126	aquaporin 2	Sus scrofa	180-184
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Arginine	242-250	serine protease 8	Homo sapiens	74-83
11101139-7	2000	Three elastases, molecular masses of 27, 29, 31 kDa, might be elastase isozymes that have the same NH2-terminal amino acid sequences of Ile-Val-Gly-Gly-Arg-Arg-Ala.	Arginine	152-155	elastase, neutrophil expressed	Homo sapiens	6-14
11101139-7	2000	Three elastases, molecular masses of 27, 29, 31 kDa, might be elastase isozymes that have the same NH2-terminal amino acid sequences of Ile-Val-Gly-Gly-Arg-Arg-Ala.	Arginine	156-159	elastase, neutrophil expressed	Homo sapiens	6-14
15474520-2	2004	Through the use of positional scanning combinatorial substrate libraries, prostasin was shown to have a preference for poly-basic substrates: in position P4 preference was for arginine or lysine; in P3 preference was for histidine, lysine or arginine; in P2 preference was for basic or large hydrophobic amino acids; and in P1 preference was for arginine and lysine.	Arginine	242-250	serine protease 8	Homo sapiens	74-83
15604023-1	2004	A guanine to adenine point mutation results in an arginine (R) to histidine (H) substitution in FcgammaRIIa at residue 131 that strongly impacts receptor function.	Arginine	50-58	Fc gamma receptor IIa	Homo sapiens	96-107
10945985-0	2000	Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase.	Arginine	0-8	nitric oxide synthase 1	Homo sapiens	61-91
10945985-3	2000	H4B-free nNOS catalyzed Arg oxidation to N(omega)-hydroxy-l-Arg (NOHA) and citrulline in both NADPH- and H(2)O(2)-driven reactions.	Arginine	24-27	nitric oxide synthase 1	Homo sapiens	9-13
15479848-2	2004	One such restriction, human Ref1, targets strains of murine leukemia virus bearing an arginine at CA residue 110 (N-MLV), resulting in decreased accumulation of viral cDNA.	Arginine	86-94	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	28-32
10878001-6	2000	In macrophages, arginase competes with nitric-oxide synthase, which converts arginine into nitric oxide.	Arginine	77-85	Nitric oxide synthase	Drosophila melanogaster	39-60
15306657-3	2004	We found that two residues that directly contact TRH, Asn-110 in transmembrane helix 3 (3.37) and Arg-306 in transmembrane helix 7 (7.39), were important for midazolam binding but another, Tyr-282 in transmembrane helix 6 (6.51), was not.	Arginine	98-101	thyrotropin releasing hormone	Homo sapiens	49-52
11041213-2	2000	Nitric oxide (NO) is generated from L-arginine by NO synthases (NOS).	Arginine	36-46	nitric oxide synthase, inducible	Cavia porcellus	50-62
10993737-0	2000	The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication.	Arginine	33-41	arginyl-tRNA synthetase 1	Homo sapiens	45-68
10993737-3	2000	A single nucleotide change, resulting in a Cys to Tyr substitution at position 599 of arginyl-tRNA synthetase, is responsible for the defective phenotype of the thermosensitive and arginine hyper-auxotroph Arg-1 cell line.	Arginine	181-189	arginyl-tRNA synthetase 1	Homo sapiens	86-109
10993737-6	2000	The Cys599 to Tyr mutation affects both the thermal stability of arginyl-tRNA synthetase and the kinetic parameters for arginine in the ATP-PP(i) exchange and tRNA aminoacylation reactions.	Arginine	120-128	arginyl-tRNA synthetase 1	Homo sapiens	65-88
15684686-5	2004	The current experiments analyze the interactions of isolated human neutrophils with PEG hydrogels modified with Arg-Gly-Asp-Ser (RGDS), a known ligand for some beta(1) and beta(3) integrins, and Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Thr-Ile-Gly-Gly (TMKIIPFNRLTIGG), a ligand for Mac-1, a beta(2) integrin.	Arginine	112-115	ral guanine nucleotide dissociation stimulator	Homo sapiens	129-133
10970779-8	2000	In conclusion, charge neutralization of Lys-84 and Arg-349 in NaDC-1 affects succinate handling, suggesting that these residues might have roles in substrate binding.	Arginine	51-54	solute carrier family 13 member 2L homeolog	Xenopus laevis	62-68
15322128-5	2004	Nevertheless, recombinant LeARG1 and -2 exhibited specificity for L-arginine over agmatine and related guanidino substrates.	Arginine	66-76	arginase 1	Solanum lycopersicum	26-39
10978616-5	2000	The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg-&gt;Arg-Arg-&gt;Met-&gt;Leu-&gt;Lys-&gt;Phe-&gt;Lys-Ala-&gt;Tyr-&gt;Ala-MCAs.	Arginine	67-70	alanyl aminopeptidase, membrane	Homo sapiens	39-44
10978616-5	2000	The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg-&gt;Arg-Arg-&gt;Met-&gt;Leu-&gt;Lys-&gt;Phe-&gt;Lys-Ala-&gt;Tyr-&gt;Ala-MCAs.	Arginine	75-78	alanyl aminopeptidase, membrane	Homo sapiens	39-44
10978616-5	2000	The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg-&gt;Arg-Arg-&gt;Met-&gt;Leu-&gt;Lys-&gt;Phe-&gt;Lys-Ala-&gt;Tyr-&gt;Ala-MCAs.	Arginine	75-78	alanyl aminopeptidase, membrane	Homo sapiens	39-44
15319871-2	2004	Previous studies have shown that individuals with the IgG1/3-binding Fc gamma RIIa-Arg/Arg131 genotype are relatively protected against high-density malaria, whereas individuals with the IgG2-binding Fc gamma RIIa-His/His131 genotype are at increased risk for developing cerebral malaria.	Arginine	83-86	Fc gamma receptor IIa	Homo sapiens	69-82
10851238-5	2000	However, pol beta also generates deletions by a different mechanism that is strongly enhanced by the substitutions at Arg(283).	Arginine	118-121	DNA polymerase beta	Homo sapiens	9-17
15199058-7	2004	Mutation to the rodent homologue glycine or glutamate resulted in a significant reduction in binding compared with native IgE, whereas conservative substitution with arginine effected a small, but statistically significant, enhancement of CD23 binding.	Arginine	166-174	Fc epsilon receptor II	Homo sapiens	239-243
10973927-1	2000	Application of cyclic stretch (10% at 1 hertz) to vascular smooth muscle cells (SMC) increased L-arginine uptake and this was associated with a specific increase in cationic amino acid transporter-2 (CAT-2) mRNA.	Arginine	95-105	solute carrier family 7 member 2	Homo sapiens	200-205
11040259-2	2000	NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1.	Arginine	76-84	N-terminal Asn amidase	Mus musculus	0-5
11040259-3	2000	An N-terminal arginine-bearing substrate protein is recognized, ubiquitylated by UBR1/E3alpha, and subsequently degraded by 26S proteasomes.	Arginine	14-22	ubiquitin protein ligase E3 component n-recognin 1	Mus musculus	81-85
15210694-0	2004	Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity.	Arginine	58-66	SMAD family member 2	Homo sapiens	0-5
11040259-3	2000	An N-terminal arginine-bearing substrate protein is recognized, ubiquitylated by UBR1/E3alpha, and subsequently degraded by 26S proteasomes.	Arginine	14-22	ubiquitin protein ligase E3 component n-recognin 1	Mus musculus	86-93
15210694-3	2004	Here we show that substitutions of Arg-462 and Cys-463 residues, which are in proximity of the C-terminal serine residues, inhibited TGFbeta type I receptor-dependent phosphorylation of the C-terminal Smad2 peptides and full-length GST-Smad2 proteins in vitro.	Arginine	35-38	SMAD family member 2	Homo sapiens	201-206
10851237-4	2000	We show that unique carboxyl-terminal arginine- and glycine-rich domains comprising the last 29 amino acids of SmD1 and the last 32 amino acids of SmD3 are necessary and sufficient for SMN binding.	Arginine	38-46	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	147-151
15210694-3	2004	Here we show that substitutions of Arg-462 and Cys-463 residues, which are in proximity of the C-terminal serine residues, inhibited TGFbeta type I receptor-dependent phosphorylation of the C-terminal Smad2 peptides and full-length GST-Smad2 proteins in vitro.	Arginine	35-38	SMAD family member 2	Homo sapiens	236-241
15210694-4	2004	In vivo, mutation of Arg-462 and Cys-463 inhibited TGFbeta1-stimulated phosphorylation of the C-terminal serine residues in Smad2.	Arginine	21-24	SMAD family member 2	Homo sapiens	124-129
15210694-5	2004	Moreover, Smad2 with mutated Arg-462 and Cys-463 was less efficient in activation of the Smad2-responsive activin-responsive element-containing luciferase reporter ARE-luc, as compared with the wild-type protein.	Arginine	29-32	SMAD family member 2	Homo sapiens	10-15
10952997-6	2000	Remarkably, arginine methylation interferes with Sky1p-mediated phosphorylation, thereby indirectly influencing the Npl3p-Mtr10p interaction in vivo and negatively regulating nuclear import of Npl3p.	Arginine	12-20	Mtr10p	Saccharomyces cerevisiae S288C	122-128
15635855-4	2001	It participates in the tubuloglomerular feedback: the cells of the macula densa produce NO via nNOS, the genetic transcription and translation of which as well as the kationic translation system ensure the transport of the L-arginine precursor and regulate very sensitively NO formation.	Arginine	223-233	nitric oxide synthase 1	Homo sapiens	95-99
15210694-5	2004	Moreover, Smad2 with mutated Arg-462 and Cys-463 was less efficient in activation of the Smad2-responsive activin-responsive element-containing luciferase reporter ARE-luc, as compared with the wild-type protein.	Arginine	29-32	SMAD family member 2	Homo sapiens	89-94
15210694-6	2004	Thus, Arg-462 and Cys-463, which are in proximity of the C-terminal serine residues, contribute to recognition and phosphorylation of the C terminus of Smad2 by type I TGFbeta receptor.	Arginine	6-9	SMAD family member 2	Homo sapiens	152-157
15289616-1	2004	Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for any amino acid.	Arginine	21-29	arginase 1	Homo sapiens	48-52
11165387-1	2001	Creatine is synthesized from arginine by L-arginine:glycine amidinotransferase (AGAT) and S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) and can be taken up by cells by creatine transporters (CRT).	Arginine	29-37	glycine amidinotransferase	Rattus norvegicus	41-78
11165387-1	2001	Creatine is synthesized from arginine by L-arginine:glycine amidinotransferase (AGAT) and S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase (GAMT) and can be taken up by cells by creatine transporters (CRT).	Arginine	29-37	guanidinoacetate N-methyltransferase	Rattus norvegicus	152-156
10933889-6	2000	However, in RARalpha and RARgamma this Ser appears to play a small role in conjunction with Arg(276) and Arg(278), respectively, for these activities.	Arginine	92-95	retinoic acid receptor gamma	Homo sapiens	25-33
10933889-6	2000	However, in RARalpha and RARgamma this Ser appears to play a small role in conjunction with Arg(276) and Arg(278), respectively, for these activities.	Arginine	105-108	retinoic acid receptor gamma	Homo sapiens	25-33
15289616-1	2004	Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for any amino acid.	Arginine	95-103	arginase 1	Homo sapiens	48-52
10899108-5	2000	A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.	Arginine	10-18	interleukin 9	Homo sapiens	67-70
15289616-2	2004	We show that all four subunits of the arginine repressor are recruited to ARG1 by Gcn4p in cells replete with arginine but starved for isoleucine/valine.	Arginine	38-46	arginase 1	Homo sapiens	74-78
15289616-2	2004	We show that all four subunits of the arginine repressor are recruited to ARG1 by Gcn4p in cells replete with arginine but starved for isoleucine/valine.	Arginine	110-118	arginase 1	Homo sapiens	74-78
15044149-7	2004	Addition of the NO donor l-arginine onto stretched cells further enhanced E(app), NOS activity, and nNOS expression, whereas the presence of the NO inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME) reversed the effects of mechanical stimulation and of l-arginine.	Arginine	25-35	nitric oxide synthase 1	Homo sapiens	100-104
10839996-1	2000	Tissue-non-specific alkaline phosphatase (TNSALP) with an Arg(54)--&gt;Cys (R54C) or an Asp(277)--&gt;Ala (D277A)substitution was found in a patient with hypophosphatasia [Henthorn,Raducha, Fedde, Lafferty and Whyte (1992) Proc.	Arginine	58-61	alkaline phosphatase, biomineralization associated	Homo sapiens	0-40
10839996-1	2000	Tissue-non-specific alkaline phosphatase (TNSALP) with an Arg(54)--&gt;Cys (R54C) or an Asp(277)--&gt;Ala (D277A)substitution was found in a patient with hypophosphatasia [Henthorn,Raducha, Fedde, Lafferty and Whyte (1992) Proc.	Arginine	58-61	alkaline phosphatase, biomineralization associated	Homo sapiens	42-48
11167791-2	2001	Sequencing of GPIX revealed a homozygous (T-->C) transition at nucleotide 1717 (GenBank/HUMGPIX/M80478), resulting in a Cys(8) (TGT)-->Arg (CGT) replacement in the mature peptide.	Arginine	135-138	glycoprotein IX platelet	Homo sapiens	14-18
15377869-1	2004	Nitric oxide is generated in vivo by nitric-oxide synthase (NOS) during the conversion of L-Arg to citrulline.	Arginine	90-95	nitric oxide synthase 1	Homo sapiens	37-58
11145569-11	2001	PRL did not further increase NO release in the presence of L-arginine (0.1 or 1 mM), but FGF-2 significantly (P: &lt;/= 0.05) increased NO release in the presence of 0.1 and 1 mM L-arginine.	Arginine	179-189	fibroblast growth factor 2	Rattus norvegicus	89-94
10848517-7	2000	These results indicate that L-arginine uptake by IMCD cells occurs via system y(+), is encoded by CAT1, and may participate in the regulation of NO production in this renal segment.	Arginine	28-38	solute carrier family 7 member 1	Rattus norvegicus	98-102
11500931-10	2001	These results indicated that combinatorial treatment of L-arginine analogs and flavonoid derivates, such as quercetin pentaacetate, effectively inhibited LPS-induced NO and PGE2 productions, at the same time, inhibited enhanced expressions of iNOS and COX-2 genes.	Arginine	56-66	prostaglandin-endoperoxide synthase 2	Mus musculus	252-257
15240449-7	2004	Structural analysis first revealed that Arg(13) played a novel and vital role of blocking the pore of the rsk2 channel, whose role is remarkably different from that of highly homologous scorpion toxin P05.	Arginine	40-43	ribosomal protein S6 kinase A3	Homo sapiens	106-110
11208993-7	2001	A T855C polymorphism resulting in a histidine to arginine transition was present in the open reading frame of NPT2.	Arginine	49-57	solute carrier family 34 member 1	Homo sapiens	110-114
10727756-5	2000	This study provides evidence that hCG activates expression of iNOS protein in murine microglial cells accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium, and further offers that TNF-alpha acts on the NO synthesis from IFN-gamma-primed murine microglial cells.	Arginine	158-168	chorionic gonadotropin subunit beta 5	Homo sapiens	34-37
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Arginine	69-72	plasminogen	Homo sapiens	13-20
15240449-8	2004	Between the interfaces in the ScyTx-rsk2 complex, strong electrostatic interaction and hydrogen bonds exist between Arg(13) of ScyTx and Gly-Tyr-Gly-Asp sequential residues located in the four symmetrical chains of the pore region.	Arginine	116-119	ribosomal protein S6 kinase A3	Homo sapiens	36-40
15064952-8	2004	Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression, via mechanisms involving membrane hyperpolarization, mitogen-activated protein kinases p42 and p44, phosphatidylinositol 3-kinase, NO and protein kinase C. We have characterized a cell signalling pathway by which hyperinsulinaemia could lead to vasodilatation in human subjects, and which could have implications in patients in whom plasma insulin levels are altered, such as in diabetes mellitus.	Arginine	36-46	interferon induced protein 44	Homo sapiens	233-236
10799524-6	2000	Arg-238 matched well to the arginine "finger" required for enhanced GTP hydrolysis in homodimerized Cdc42.	Arginine	0-3	cell division cycle 42	Homo sapiens	100-105
10799524-6	2000	Arg-238 matched well to the arginine "finger" required for enhanced GTP hydrolysis in homodimerized Cdc42.	Arginine	28-36	cell division cycle 42	Homo sapiens	100-105
11150917-1	2001	Nitric oxide synthase (NOS) catalyzes nitric oxide (NO) formation from L-arginine in the presence of molecular oxygen and NADPH.	Arginine	71-81	nitric oxide synthase 1	Homo sapiens	0-21
15212981-3	2004	L-NAME given before the ischemia exacerbated neutrophil accumulation, plasma extravasation, serum TNF and caused death of the animals, which was prevented by concomitant injection of L-arginine.	Arginine	183-193	tumor necrosis factor-like	Rattus norvegicus	98-101
11833938-5	2001	In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors (NOC-18 and spermine-NONOate) or the NOS substrate (L-arginine) stimulate, whereas NOS inhibitors (N(G)-nitro-L-arginine methyl ester and N(G)-monomethyl-L-arginine) reduce the expression and gelatinolytic activity of MMP-2 and MMP-9 in isolated trophoblast cells.	Arginine	191-201	matrix metallopeptidase 2	Homo sapiens	104-109
10799524-8	2000	From deletion studies, a region adjacent to the arginine patch ((288)EYV(290) on BNIP-2) and the Switch I and Rho family-specific "Insert" region on Cdc42 are involved in the binding.	Arginine	48-56	cell division cycle 42	Homo sapiens	149-154
10773584-2	2000	The aminoterminal segment, Arg(8)-Leu(9)-Val(10)-Gly(11) (RLVG), of the single polypeptide chain of cystatin C constitutes an essential part of its inhibitory center.	Arginine	27-30	cystatin C	Homo sapiens	100-110
15197253-7	2004	Deletion and site-specific mutational analyses show that arginine 73 in ABI1 is essential for PA-ABI1 binding.	Arginine	57-65	Protein phosphatase 2C family protein	Arabidopsis thaliana	72-76
10773584-8	2000	In contrast to wild-type cystatin C, recombinant human cystatin C with Gly substitutions for residues Arg(8), Leu(9), Val(10), and Trp(106), and with low or nonexistent affinity for cysteine proteinases, did not display any inhibitory effect on bone resorption.	Arginine	102-105	cystatin C	Homo sapiens	55-65
10775627-5	2000	In this study, we have focused on the leucine/isoleucine-rich domain near the carboxyl terminus of Vpr at residue 73 (arginine) and have demonstrated that alterations at this residue result in ablation of transcriptional activity of Vpr and its ability to block cell cycle events at the G(2) stage.	Arginine	118-126	Vpr	Human immunodeficiency virus 1	99-102
11121027-7	2000	His64 in CA XII acts as a proton shuttle residue, as evidenced by the reduced rate constant for proton transfer in the mutants containing the replacements His64 --&gt; Ala and His64 --&gt; Arg, as well as by the selective inhibition of the proton transfer step by cupric ions in wild-type CA XII.	Arginine	189-192	carbonic anhydrase 12	Homo sapiens	9-15
15197253-7	2004	Deletion and site-specific mutational analyses show that arginine 73 in ABI1 is essential for PA-ABI1 binding.	Arginine	57-65	Protein phosphatase 2C family protein	Arabidopsis thaliana	97-101
10775627-5	2000	In this study, we have focused on the leucine/isoleucine-rich domain near the carboxyl terminus of Vpr at residue 73 (arginine) and have demonstrated that alterations at this residue result in ablation of transcriptional activity of Vpr and its ability to block cell cycle events at the G(2) stage.	Arginine	118-126	Vpr	Human immunodeficiency virus 1	233-236
15040788-3	2004	However, owing to preferential hydrolysis of Phe-Arg compared with the Arg-Ala bond in the peptide derived from rat LMWK, hK1 released bradykinin only from the mouse LMWK fragment and preferentially released des-[Arg9]bradykinin from the rat LMWK fragment (Abz-MTSVIRRPPGFSPFRAPRV-NH2).	Arginine	49-52	keratin 1	Homo sapiens	122-125
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	Arginine	146-149	keratin 1	Homo sapiens	224-227
15163799-7	2004	Replacements of lysine residues with arginine showed that Siah1A-mediated ubiquitination occurs at multiple lysine residues spanning both the seven-transmembrane region and carboxyl-terminal tail of mGluR5.	Arginine	37-45	siah E3 ubiquitin protein ligase 1	Homo sapiens	58-64
11095729-4	2000	Both proteins were C-terminally extended by the C-terminal half of ubiquitin followed by a modified Ura3p with an arginine in position 1, a destabilizing residue in the N-end rule pathway.	Arginine	114-122	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	100-105
15163799-7	2004	Replacements of lysine residues with arginine showed that Siah1A-mediated ubiquitination occurs at multiple lysine residues spanning both the seven-transmembrane region and carboxyl-terminal tail of mGluR5.	Arginine	37-45	glutamate receptor, ionotropic, kainate 1	Mus musculus	199-205
15224130-2	2004	NO synthase (NOS) catalyzes production of NO from L-arginine.	Arginine	50-60	nitric oxide synthase 1	Homo sapiens	0-11
11069235-4	2000	Tat proteins with inactivating substitutions in the arginine-glycine-aspartic acid or basic domain were still active in inducing PMNL migration, whereas Tat peptides mapped the migration and Ca(2+) mobilization activity to a cysteine-rich core domain, previously described as a Tat "chemokine-like" region (peptide CysL(24-51)).	Arginine	52-60	tyrosine aminotransferase	Homo sapiens	0-3
10779667-12	2000	This novel effect appears to be initiated by the transient inhibition of nNOS as delayed anti-nociception was mimicked by 7-NI at doses (10-100 nmol) that no longer inhibited spinal nNOS (25 nmol) at 24 h. Co-administration with L-arginine prevented the delayed (24 h) anti-nociceptive effects of L-NAME (30 nmol).	Arginine	229-239	nitric oxide synthase 1, neuronal	Mus musculus	73-77
10836796-6	2000	Deletion mutagenesis identified a region rich in arginine residues located in the N-terminus that is responsible for binding of ADAR3 to ssRNA.	Arginine	49-57	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	128-133
15171695-8	2004	At all ages studied, glucose and arginine administration stimulated an increase in the plasma concentrations of insulin and proinsulin; these beta cell responses did not change significantly with postnatal age.	Arginine	33-41	INS	Equus caballus	112-119
10753952-10	2000	These results indicate that Arg(103) in HCII molecule is not critical for the interaction with Ca-SP.	Arginine	28-31	serpin family D member 1	Homo sapiens	40-44
10733677-5	2000	Because the EDA segment enhances the integrin binding sequence Arg, Gly, Asp (RGD), which, when present, has been shown to be critical in integrin-extracellular matrix signaling, we were particularly interested in determining whether or not EDA-containing Fn (EDA+Fn) represented the aberrantly expressed Fn in psoriasis.	Arginine	63-66	ectodysplasin A	Homo sapiens	12-15
10704230-0	2000	Escherichia coli ATP synthase alpha subunit Arg-376: the catalytic site arginine does not participate in the hydrolysis/synthesis reaction but is required for promotion to the steady state.	Arginine	44-47	ATPase	Escherichia coli	17-20
10704230-0	2000	Escherichia coli ATP synthase alpha subunit Arg-376: the catalytic site arginine does not participate in the hydrolysis/synthesis reaction but is required for promotion to the steady state.	Arginine	72-80	ATPase	Escherichia coli	17-20
10692466-6	2000	Site-directed mutagenesis of Val-434, Arg-513, and Val-523 in mouse COX-2 to their COX-1 equivalents resulted in abrogation of 11- and 15-HETE production after aspirin treatment, confirming the hypothesis that these residues are the major isoform selectivity determinants regulating HETE production.	Arginine	38-41	cytochrome c oxidase II, mitochondrial	Mus musculus	68-73
10688832-6	2000	AMG inhibition was reversed by the addition of L-arginine, the substrate for iNOS.	Arginine	47-57	amelogenin X-linked	Homo sapiens	0-3
10677296-3	2000	In one family with OSMED, a homozygous Gly-->Arg substitution has been described in COL11A2, which codes for the alpha2 chain of type XI collagen.	Arginine	45-48	collagen type XI alpha 2 chain	Homo sapiens	84-91
10683200-4	2000	Also the inducible NOS (iNOS) selective inhibitor N-(3-(acetaminomethyl)-benzyl)acetamide (1400 W; 10(-6) M) inhibited the VIP-induced relaxation, but its inhibitory effect was not reversed by L-arginine.	Arginine	193-203	nitric oxide synthase, inducible	Cavia porcellus	24-28
10698112-10	2000	As a result of this and the absence of other negatively charged residues the distal (substrate binding) side of P450 should be less negative than that of NOS and therefore its affinity toward the partially positive arginine is reduced.	Arginine	215-223	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	112-116
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	Arginine	91-94	secreted phosphoprotein 1	Mus musculus	0-11
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	Arginine	91-94	secreted phosphoprotein 1	Mus musculus	13-16
10691775-8	2000	Significant inter-regulation among arginine pathways occurs within the three metabolic major pathways within the cell: (1) nitric oxide synthase (2) arginase and ornithine decarboxylase, and (3) arginine decarboxylase.	Arginine	35-43	ornithine decarboxylase 1	Homo sapiens	162-185
10642318-14	2000	We next evaluated the role of iNOS and nNOS in the response to L-Arg.	Arginine	63-68	nitric oxide synthase 1, neuronal	Mus musculus	39-43
10642318-15	2000	Addition of 0.5 mmol/L L-Arg to the bath decreased J(Cl) in THALs from iNOS and nNOS knockout mice by 37.7+/-6.4% (P&lt;0.05) and 31.8+/-8.3% (P&lt;0.01), respectively.	Arginine	23-28	nitric oxide synthase 1, neuronal	Mus musculus	80-84
10678543-12	2000	Enhanced renal and systemic responses to L-arg after ACE inhibitor and AT1B were associated with a rise in plasma L-citrulline levels, which was greater than after control L-arg (P &lt; 0.05).	Arginine	41-46	angiotensin II receptor type 1	Homo sapiens	71-75
10678543-12	2000	Enhanced renal and systemic responses to L-arg after ACE inhibitor and AT1B were associated with a rise in plasma L-citrulline levels, which was greater than after control L-arg (P &lt; 0.05).	Arginine	172-177	angiotensin II receptor type 1	Homo sapiens	71-75
10678543-14	2000	CONCLUSION: The results indicate that ACE inhibitors and AT1B have a potential to enhance L-arg-induced vasodilation both in systemic and renal vascular beds.	Arginine	90-95	angiotensin II receptor type 1	Homo sapiens	57-61
12845750-7	2000	Imaging analysis showed that L-NAME could inhibit the expression of IL-4 mRNA (P &lt; 0.05) and increase the expression of IFN-gamma mRNA (P &lt; 0.05), while L-Arg could increase the expression of IL-4 mRNA in inflammatory cells (P &lt; 0.05).	Arginine	159-164	interleukin 4	Rattus norvegicus	198-202
10647067-9	2000	L-Arginine was able to counteract the inhibitory effect of ET-1 on cGMP and GK activity.	Arginine	0-10	glucokinase	Rattus norvegicus	76-78
10590419-2	2000	This homozygous T-to-C transition results in the replacement of a highly conserved tryptophan at amino acid position (aa) 797 with an arginine in the C-terminal domain of the PYGM protein.	Arginine	134-142	glycogen phosphorylase, muscle associated	Homo sapiens	175-179
11155802-1	2000	The gaseous radical nitric oxide (NO) is catalyzed by conversion of L-arginine to L-citrulline by one cytokine inducible form (iNOS), which becomes active only within hours after the inducing event, and by two constitutively expressed forms, endothelial (eNOS) and neuronal (nNOS), which are regulated by the cytosolic concentration of free Ca2+.	Arginine	68-78	nitric oxide synthase 1	Homo sapiens	275-279
10665665-7	1999	The frequency of DQA1 allele *0301, which encode for an Arg at codon 52, was significantly higher in the IDDM patients compared to the controls (p&lt;0.001).	Arginine	56-59	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	17-21
10630682-3	1999	Endogenous NO is generated from arginine by a family of three distinct calmodulin- dependent NO synthase (NOS) enzymes.	Arginine	32-40	nitric oxide synthase 1	Homo sapiens	93-104
10570058-7	1999	Finally, L-arginine (10 mM) and NOC-18 (0.3 mM) inhibited both basal and Fe/Asc (0.1 mM/0.2 mM)-stimulated lipid peroxidation in X. laevis oocytes.	Arginine	9-19	PYD and CARD domain containing L homeolog	Xenopus laevis	76-79
10548560-8	1999	Moreover, stimulation of l-arginine transport and induction of NO synthesis by LPS and IFN-gamma appear to be under critical regulation by the p38 MAPK, since both processes were significantly modified by SB203580 at concentrations so far shown to have no effect on other signalling pathways.	Arginine	25-35	mitogen activated protein kinase 14	Rattus norvegicus	143-146
10548560-9	1999	Thus, in RASMCs, the p38 MAPK cascade represents an important signalling mechanism, regulating both enhanced l-arginine transport and induced NO synthesis.	Arginine	109-119	mitogen activated protein kinase 14	Rattus norvegicus	21-24
10548560-9	1999	Thus, in RASMCs, the p38 MAPK cascade represents an important signalling mechanism, regulating both enhanced l-arginine transport and induced NO synthesis.	Arginine	109-119	mitogen activated protein kinase 3	Rattus norvegicus	25-29
10553049-5	1999	Ly-49D signaling in Jurkat leads to tyrosine phosphorylation of TCRzeta and requires Syk/Zap70 family kinases and arginine 54 of Ly-49D, suggesting that Ly-49D signals via association with TCRzeta.	Arginine	114-122	killer cell lectin like receptor A1, pseudogene	Homo sapiens	0-6
10553049-5	1999	Ly-49D signaling in Jurkat leads to tyrosine phosphorylation of TCRzeta and requires Syk/Zap70 family kinases and arginine 54 of Ly-49D, suggesting that Ly-49D signals via association with TCRzeta.	Arginine	114-122	killer cell lectin like receptor A1, pseudogene	Homo sapiens	129-135
10553049-5	1999	Ly-49D signaling in Jurkat leads to tyrosine phosphorylation of TCRzeta and requires Syk/Zap70 family kinases and arginine 54 of Ly-49D, suggesting that Ly-49D signals via association with TCRzeta.	Arginine	114-122	killer cell lectin like receptor A1, pseudogene	Homo sapiens	129-135
10542231-5	1999	The comparison of the results obtained by phage display and substitution analysis permitted the identification of proline and arginine at positions 4 and 6 in the PIRPSR and PTIPPR target sequence as the major determinants of the recognition specificity mediated by the SH3 domain of amphiphysin 1.	Arginine	126-134	amphiphysin	Homo sapiens	284-295
11090190-1	2000	The activity of human immunodeficiency virus Rev as a regulator of viral mRNA expression is tightly linked to its ability to shuttle between the nucleus and cytoplasm; these properties are conferred by a leucine-rich nuclear export signal (NES) and by an arginine-rich nuclear localization signal/RNA binding domain (NLS/RBD) required for binding to the Rev-responsive element (RRE) located on viral unspliced and singly spliced mRNAs.	Arginine	255-263	Rev	Human immunodeficiency virus 1	45-48
11090190-1	2000	The activity of human immunodeficiency virus Rev as a regulator of viral mRNA expression is tightly linked to its ability to shuttle between the nucleus and cytoplasm; these properties are conferred by a leucine-rich nuclear export signal (NES) and by an arginine-rich nuclear localization signal/RNA binding domain (NLS/RBD) required for binding to the Rev-responsive element (RRE) located on viral unspliced and singly spliced mRNAs.	Arginine	255-263	Rev	Human immunodeficiency virus 1	354-357
11087420-7	2000	Our results indicate that the carboxylate-binding loop Lys or Arg is a critical determinant of nNOS binding and that the identity of this residue can profoundly alter one mode of PDZ recognition without affecting another.	Arginine	62-65	nitric oxide synthase 1	Homo sapiens	95-99
11029280-6	2000	At saturating [L-Arg](o), the current-voltage relationships of hCAT-2A-expressing oocytes became steeper, yielding an additional conductance up to 2 microS/oocyte, whereas those of hCAT-2B-expressing oocytes were simply shifted to the right, resulting in voltage-independent difference currents.	Arginine	15-20	solute carrier family 7 member 2	Homo sapiens	63-69
11092532-3	2000	NO is produced from arginine by nitric oxide synthase (NOS), an enzyme that exists in both constitutive and inducible (iNOS) forms.	Arginine	20-28	nitric oxide synthase 1, neuronal	Mus musculus	32-53
11217646-8	2000	RESULTS: L-arginine infusion induced a significant increase in both CCr and CIn.	Arginine	9-19	pyridoxal phosphatase	Homo sapiens	76-79
11217646-12	2000	CONCLUSIONS: L-arginine induces a substantial increase of CCr, which exceeds that expected from the increase in glomerular filtration rate measured by CIn and corresponds to an increment in TSCr.	Arginine	13-23	pyridoxal phosphatase	Homo sapiens	151-154
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Arginine	104-107	carboxypeptidase B2	Homo sapiens	0-4
11022003-4	2000	All three suppressor mutations suppressed the effects of Ala, Arg, or Leu at the N-terminus of nsP4 with almost equal efficiency and thus the effect of the suppressing mutation is independent of the nsP4 N-terminal residue.	Arginine	62-65	serine protease 57	Homo sapiens	95-99
11022003-6	2000	Combinations of nsP1-T349K or nsP4-E315G with Leu, Arg, His, or any aromatic amino acid at the N-terminus of nsP4 also made the mutant viruses temperature sensitive.	Arginine	51-54	serine protease 57	Homo sapiens	109-113
11028476-2	2000	BACKGROUND: beta2-adrenergic agonists such as albuterol dilate forearm resistance vessels, partly by activating the L-arginine/nitric oxide pathway.	Arginine	116-126	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	12-17
10566637-5	1999	In one allele, an undescribed G to C transversion in codon 217, which occurred at the last base of exon 5 and thus altered the splice donor site sequence, apparently resulted in a substitution of Arg to Thr (AGG to ACG: R217T), and in the other allele, a C to T transition in codon 218 caused a substitution of Ala to Val (GCG to GTG: A218V), which has been previously shown to abolish StAR activity.	Arginine	196-199	steroidogenic acute regulatory protein	Homo sapiens	386-390
10587254-0	1999	Acute insulin response to intravenous arginine in nonobese healthy cats.	Arginine	38-46	insulin	Felis catus	6-13
15194051-11	2004	We conclude that the arginine 22 amino acid residue of IP-10 is essential for both CXCR3 binding and angiostasis.	Arginine	21-29	C-X-C motif chemokine receptor 3	Homo sapiens	83-88
10587254-1	1999	The purpose of this study was to document and characterize insulin response to intravenous administration of arginine, a nonglucose secretagogue, and compare it to insulin response during intravenous glucose tolerance tests (IVGTTs) in clinically healthy nonobese cats.	Arginine	109-117	insulin	Felis catus	59-66
10587254-2	1999	In addition, we examined the influence of plasma glucose level on insulin response to arginine in cats.	Arginine	86-94	insulin	Felis catus	66-73
10587254-4	1999	All doses of arginine elicited an abrupt insulin response that peaked at 2-4 minutes and returned to basal concentrations within 30 minutes.	Arginine	13-21	insulin	Felis catus	41-48
10587254-5	1999	Mean insulin peak response (IPR) and mean area under the curve of plasma insulin concentration evaluated for the initial 10 minutes after administration (AUC10) increased with each progressive increase in arginine dosage.	Arginine	205-213	insulin	Felis catus	5-12
10587254-5	1999	Mean insulin peak response (IPR) and mean area under the curve of plasma insulin concentration evaluated for the initial 10 minutes after administration (AUC10) increased with each progressive increase in arginine dosage.	Arginine	205-213	insulin	Felis catus	73-80
10587254-6	1999	An asymptotic maximal response estimated by mean insulin AUC10 reached plateau at 0.1-0.2 g arginine/kg.	Arginine	92-100	insulin	Felis catus	49-56
15165181-3	2004	The sequence of ZmDRH1 includes the eight RNA helicase motifs and two glycine-rich regions with arginine-glycine-rich (RGG) boxes at the amino (N)- and carboxy (C)-termini of the protein.	Arginine	96-104	DEAD box RNA helicase 1	Zea mays	16-22
10587254-10	1999	Mild hyperglycemia (211 +/- 6 mg/dL) induced by variable infusion rate of glucose resulted in a significant (P &lt; .05) potentiation of insulin response to arginine; mean insulin AUC10 increased 287 +/- 26 to 551 +/- 167 microU/mL/10 minutes.	Arginine	157-165	insulin	Felis catus	137-144
10587254-10	1999	Mild hyperglycemia (211 +/- 6 mg/dL) induced by variable infusion rate of glucose resulted in a significant (P &lt; .05) potentiation of insulin response to arginine; mean insulin AUC10 increased 287 +/- 26 to 551 +/- 167 microU/mL/10 minutes.	Arginine	157-165	insulin	Felis catus	172-179
10587254-11	1999	These findings indicate that the arginine challenge is a more meaningful tool than is the IVGTT for evaluating the insulin secretory capacity in cats.	Arginine	33-41	insulin	Felis catus	115-122
10496984-12	1999	Collectively, our results demonstrate that conformation-dependent arginine-mediated ionic interactions are responsible for the TFPI-2/MSPI triplet binding to fibroblast ECM, heparin, and dermatan sulfate and that heparin augmented the rate of inhibition of plasmin by TFPI-2/MSPI.	Arginine	66-74	plasminogen	Homo sapiens	257-264
15166534-6	2004	However, frequency of the infant Fc gamma RIIa His/His131 genotype was higher in HIV-positive compared with HIV-negative infants (35% and 21%, respectively), whereas the distribution was reversed (15% and 28%, respectively) for infants with the Fc gamma RIIa Arg/Arg131 genotype.	Arginine	259-262	Fc gamma receptor IIa	Homo sapiens	33-46
10523035-2	1999	This patient bore a novel point mutation (T for A) at codon 168 of the gene encoding the GnRH receptor (GnRH-R), resulting in a serine to arginine change in the fourth transmembrane domain of the receptor.	Arginine	138-146	gonadotropin releasing hormone receptor	Homo sapiens	104-110
15078957-10	2004	One of the interesting differences between the MDV vIL-8 gene and its cellular counterpart is the presence of a DKR (Asp-Lys-Arg) motif instead of ELR (Glu-Leu-Arg) preceding the invariable CXC motif.	Arginine	125-128	villin 1	Homo sapiens	51-54
10500145-2	1999	In both structures, a bicarbonate anion is bound to an arginine side chain (Arg-356 in PepA and Arg-336 in leucine aminopeptidase) very near two catalytic zinc ions.	Arginine	55-63	peptidase A	Bos taurus	87-91
10500145-2	1999	In both structures, a bicarbonate anion is bound to an arginine side chain (Arg-356 in PepA and Arg-336 in leucine aminopeptidase) very near two catalytic zinc ions.	Arginine	76-79	peptidase A	Bos taurus	87-91
10987858-5	2000	Electrophysiological whole-cell patch-clamp recordings show that, of the eight arginine residues tested, the two arginines at positions 70 and 123 appear to be essential for the GABA-gated chloride current because the EC(50) values of the two mutant constructs increase &gt;100-fold compared with the wild-type alpha(5),beta(2), gamma(2s) GABA(A) receptor.	Arginine	113-122	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	320-327
10764765-6	2000	Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding and identify by site-directed mutagenesis several key residues (Lys(1292), Leu(1298), Arg(1299), Arg(1300), Gln(1301), and Ser(1303)).	Arginine	186-189	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	63-67
10764765-6	2000	Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding and identify by site-directed mutagenesis several key residues (Lys(1292), Leu(1298), Arg(1299), Arg(1300), Gln(1301), and Ser(1303)).	Arginine	197-200	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	63-67
10764765-6	2000	Here, we show that residues 1290-1309 in the cytosolic tail of NR2B are critical for CaMKII binding and identify by site-directed mutagenesis several key residues (Lys(1292), Leu(1298), Arg(1299), Arg(1300), Gln(1301), and Ser(1303)).	Arginine	197-200	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	85-91
10493814-1	1999	The kinetics of binding L-arginine and three alternative substrates (homoarginine, N-methylarginine, and N-hydroxyarginine) to neuronal nitric oxide synthase (nNOS) were characterized by conventional and stopped-flow spectroscopy.	Arginine	24-34	nitric oxide synthase 1	Homo sapiens	127-157
10493814-1	1999	The kinetics of binding L-arginine and three alternative substrates (homoarginine, N-methylarginine, and N-hydroxyarginine) to neuronal nitric oxide synthase (nNOS) were characterized by conventional and stopped-flow spectroscopy.	Arginine	24-34	nitric oxide synthase 1	Homo sapiens	159-163
15133828-0	2004	Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report.	Arginine	0-3	GTP cyclohydrolase 1	Homo sapiens	19-39
10455016-2	1999	Single amino acid mutations in human CYP17, Arg(347)--&gt;His and Arg(358)--&gt;Gln, have been reported to result in the loss of the lyase activity and to cause sexual phenotypic changes in 46XY male patients.	Arginine	44-47	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	37-42
10455016-2	1999	Single amino acid mutations in human CYP17, Arg(347)--&gt;His and Arg(358)--&gt;Gln, have been reported to result in the loss of the lyase activity and to cause sexual phenotypic changes in 46XY male patients.	Arginine	66-69	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	37-42
10455016-3	1999	By using site-directed mutagenesis we show here that another mutation in human CYP17, Arg(449)--&gt;Ala, for which human variants have yet not been described, also leads to selective lyase deficiency.	Arginine	86-89	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-84
10954027-2	2000	The prevalence of the Arg allele of the Arg16Gly polymorphism in the beta2-ADR gene was higher (49%) in males with a body mass index (BMI) of 35 kg/m2 or higher versus those with a BMI less than 35 kg/m2 (33%; P = .010).	Arginine	22-25	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	69-74
21166191-9	2004	CONCLUSION: L-arginine liposome could lower the mPAP and lighten the remodeling of pulmonary arterioles of the rats chronically exposed to hypoxia-hypercapnia than L-arginine does.	Arginine	12-22	phospholipid phosphatase 1	Mus musculus	48-52
10935550-7	2000	Substitution of L124 in the hbeta2-AR with arginine, lysine, or alanine resulted in constitutive activation as evidenced by increased basal levels of cAMP that could be attenuated by an inverse agonist.	Arginine	43-51	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	163-166	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	237-242
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	173-176	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	237-242
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	173-176	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	237-242
15084284-9	2004	Phosphorylation by Arg also promotes p190RhoGAP"s association with p120RasGAP and stimulates p190RhoGAP"s ability to induce neuritogenesis in neuroblastoma cells.	Arginine	19-22	Rho GTPase activating protein 35	Mus musculus	93-103
10513616-0	1999	Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase.	Arginine	22-32	nitric oxide synthase 1	Homo sapiens	78-99
15066178-5	2004	Using heparin affinity chromatography, commonly employed in such studies, we define three clusters of arginines and lysines of CCP3, which are important for the interaction of PAPP-A with heparin.	Arginine	102-111	pappalysin 1	Homo sapiens	176-182
10513616-1	1999	Several L-arginine analogs are known as potent inhibitors of nitric oxide synthase (NOS).	Arginine	8-18	nitric oxide synthase 1	Homo sapiens	61-82
10522802-1	1999	OBJECTIVE AND DESIGN: The role of a tetrapeptide derivative PEP 1261 {Boc-Lys(Boc)-Arg-Asp-Ser(tBu)-OtBu}, corresponding to residues 39-42 of human lactoferrin, has been tested in vitro in the modulation of neutrophil function.	Arginine	83-86	prolyl endopeptidase	Homo sapiens	60-63
10944418-1	2000	Nitric oxide (NO), a biomolecule with major cytotoxic potency, is generated by NO synthases (NOS) utilizing l-arginine as substrate and citrulline is formed as a "side product."	Arginine	108-118	nitric oxide synthase 1, neuronal	Mus musculus	79-91
14718525-3	2004	Here we show that S. pombe lacking tsc1+ or tsc2+ have similar phenotypes including decreased arginine uptake, decreased expression of three amino acid permeases, and low intracellular levels of four members of the arginine biosynthesis pathway.	Arginine	94-102	TSC complex subunit 1	Mus musculus	35-39
10951564-6	2000	Mutational analysis demonstrated that lysine 265 and/or arginine 266 were required for nuclear import of ETO, but that the surrounding basic residues were not critical.	Arginine	56-64	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	105-108
10987649-5	1999	Arginine 249 is located at the C-terminus of GTPCH, outside the catalytic site.	Arginine	0-8	GTP cyclohydrolase 1	Homo sapiens	45-50
14718525-3	2004	Here we show that S. pombe lacking tsc1+ or tsc2+ have similar phenotypes including decreased arginine uptake, decreased expression of three amino acid permeases, and low intracellular levels of four members of the arginine biosynthesis pathway.	Arginine	215-223	TSC complex subunit 1	Mus musculus	35-39
10956202-1	2000	Nitric oxide synthase (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO).	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	0-21
14718525-5	2004	We show that the defect in arginine uptake in cells lacking tsc2+ is rescued by the expression of a dominant negative form of rhb1+, the Rheb homolog in S. pombe, but not by expressing wild-type rhb1+.	Arginine	27-35	Ras homolog, mTORC1 binding	Homo sapiens	137-141
10482317-8	1999	The apparent amino acid residue in position 143 (Pen alloantigen) of canine platelet beta3 is histidine compared with arginine in human beings.	Arginine	118-126	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	85-90
14718525-7	2004	Taken together, these findings support a model in which arginine uptake is regulated through tsc1+, tsc2+, and rhb1+ in S. pombe and also suggest a role for the Tsc1 and Tsc2 proteins in amino acid biosynthesis and sensing.	Arginine	56-64	TSC complex subunit 1	Mus musculus	93-97
14718531-7	2004	Using [(32)P]Glc-6-P coupled with cyanogen bromide mapping, we demonstrated that the phosphate acceptor in Glc-6-Pase-beta is His(167) and that it lies inside the ER lumen with the active site residues, Arg(79) and His(114).	Arginine	203-206	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	107-117
14688266-10	2004	Replacing Arg-1753 of Prp8 by either Lys, Ala, Gln, or Glu resulted in suppression of helicase-defective Prp22 mutants.	Arginine	10-13	U4/U6-U5 snRNP complex subunit PRP8	Saccharomyces cerevisiae S288C	22-26
10440902-1	1999	Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline.	Arginine	120-128	myelin basic protein	Homo sapiens	0-20
10440902-1	1999	Myelin basic protein (MBP) occurs as a number of charge isomers due to phosphorylation, deamidation, and deimination of arginine to citrulline.	Arginine	120-128	myelin basic protein	Homo sapiens	22-25
10889016-1	2000	The crystal structure of the complex formed between recombinant yeast orotidine 5"-phosphate decarboxylase and the competitive inhibitor 6-hydroxyuridine 5"-phosphate reveals the presence of four hydrogen bonds between active site residues Tyr-217 and Arg-235 and the phosphoryl group of this inhibitor.	Arginine	252-255	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	70-106
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	12-15	plasminogen	Homo sapiens	128-135
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	170-178	plasminogen	Homo sapiens	128-135
14688266-10	2004	Replacing Arg-1753 of Prp8 by either Lys, Ala, Gln, or Glu resulted in suppression of helicase-defective Prp22 mutants.	Arginine	10-13	DEAH-box ATP-dependent RNA helicase PRP22	Saccharomyces cerevisiae S288C	105-110
10404387-0	1999	Monoclonal antibody specific to a subclass of polyproline-Arg motif provides evidence for the presence of an snRNA-free spliceosomal Sm protein complex in vivo: implications for molecular interactions involving proline-rich sequences of Sm B/B" proteins.	Arginine	58-61	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	237-243
10404387-9	1999	To our knowledge, 3E10 is the first well characterized mAb specific for a subclass of polyproline-arg motif recognizing Sm B/B" and CD2 proteins.	Arginine	98-101	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	120-126
15069780-1	2004	It has been suggested that the Arg 16/Gly 16 allele at codon 16 of beta 2-adrenoceptor polymorphism plays a role in down-regulating the stimulus of bronchodilatation caused by beta 2-agonists.	Arginine	31-34	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	67-73
10395590-7	1999	Removal of arginine, proline, threonine, tryptophan or valine inhibited the stimulation of IGF-I expression that was induced by the combination of T3, DEX and GH (to 15, 6, 11, 16 and 16% of control, respectively, P &lt; 0.05), with significant decreases in GHR expression also observed in some cases.	Arginine	11-19	insulin like growth factor 1	Sus scrofa	91-96
10395590-8	1999	The stimulatory effect of some of these amino acids (arginine, proline, threonine and tryptophan) was dose-dependent for expression of class 1 transcripts of IGF-I (P = 0.	Arginine	53-61	insulin like growth factor 1	Sus scrofa	158-163
10940891-1	2000	To determine the contribution of the somatic point mutations and that of the complementarity-determining region (CDR)3 Arg to DNA binding, we engineered the germline V(H) and V(kappa) gene revertant and site-mutagenized the CDR3 Arg residues of the mutated and "antigen-selected" mAb 412.67.	Arginine	119-122	CDR3	Homo sapiens	113-118
15069780-2	2004	This study was designed to evaluate the difference of bronchodilator responsiveness to beta 2-agonist (procaterol) and anti-cholinergic drug (oxitropium) between those who have Arg 16/Gly 16 allele (hetero type) and those who have Gly 16/Gly 16 allele (variant type) at codon 16 of in healthy women.	Arginine	177-180	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	87-93
14689302-4	2004	The mutation, 83G--&gt;C, is predicted to result in the substitution of arginine by proline (R28P) in the N-terminal subdomain of PAX9 paired domain.	Arginine	72-80	paired box 9	Homo sapiens	130-134
10747894-3	2000	Here we demonstrate by protein sequencing and mass spectrometry that all arginines in the C-terminal arginine-glycine (RG) dipeptide repeats of the human Sm proteins D1 and D3, isolated from HeLa small nuclear ribonucleoproteins, contain symmetrical dimethylarginines (sDMAs), a posttranslational modification thus far only identified in the myelin basic protein.	Arginine	73-82	myelin basic protein	Homo sapiens	342-362
10775676-3	2000	A first report on the DNA and deduced amino acid sequence showed that DMP1 has a single Arg-Gly-Asp (RGD) sequence.	Arginine	88-91	dentin matrix acidic phosphoprotein 1	Rattus norvegicus	70-74
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Arginine	66-69	mal, T cell differentiation protein	Canis lupus familiaris	29-32
10405166-5	1999	Apoptosis induced by PTP-S2 in MCF7 cells was inhibited by cotransfection with mutant p53 (Arg-273 --&gt; His) but not by wild type p53.	Arginine	91-94	protein tyrosine phosphatase receptor type U	Homo sapiens	21-24
10866048-0	2000	Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene.	Arginine	79-87	islet amyloid polypeptide	Homo sapiens	60-66
14684170-1	2004	Arginine decarboxylase (ADC) catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine (Put) from arginine (Arg).	Arginine	118-126	arginine decarboxylase 1	Arabidopsis thaliana	0-22
10866048-6	2000	In addition, to determine if the beta-cell secretory defect in response to arginine involves amylin in addition to insulin secretion, we analyzed samples from 17 previously studied RW pedigree subjects.	Arginine	75-83	islet amyloid polypeptide	Homo sapiens	93-99
10362683-11	1999	These findings suggest that together CAT-1 and CAT-2B play an important role in providing substrate for high-output NO synthesis in vitro as well as in vivo and implicate a coordinated regulation of intracellular iNOS enzyme activity with membrane arginine transport.	Arginine	248-256	solute carrier family 7 member 1	Rattus norvegicus	37-42
14684170-1	2004	Arginine decarboxylase (ADC) catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine (Put) from arginine (Arg).	Arginine	118-126	arginine decarboxylase 1	Arabidopsis thaliana	24-27
10428379-1	1999	Conformationally restricted arginine analogues (1-5) were synthesized and found to be alternative substrates or inhibitors of the three isozymes of nitric oxide synthase (NOS).	Arginine	28-36	nitric oxide synthase 1	Homo sapiens	148-169
10805755-3	2000	N-terminal arginine of a substrate protein is bound by the Ubr1-encoded E3alpha, the E3 component of the ubiquitin-proteasome-dependent N-end rule pathway.	Arginine	11-19	ubiquitin protein ligase E3 component n-recognin 1	Mus musculus	59-63
10805755-3	2000	N-terminal arginine of a substrate protein is bound by the Ubr1-encoded E3alpha, the E3 component of the ubiquitin-proteasome-dependent N-end rule pathway.	Arginine	11-19	ubiquitin protein ligase E3 component n-recognin 1	Mus musculus	72-79
14684170-1	2004	Arginine decarboxylase (ADC) catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine (Put) from arginine (Arg).	Arginine	0-3	arginine decarboxylase 1	Arabidopsis thaliana	24-27
12962541-9	2004	The computed simulations detailing the docking of Pi1 peptides on to the Kv1.2 channels support an unexpected key role of specific basic amino acid residues, which form a basic ring (Arg-5, Arg-12, Arg-28 and Lys-31 residues), in toxin binding.	Arginine	183-186	Pancreas inflammation QTL 1	Rattus norvegicus	50-53
10814707-0	2000	Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine.	Arginine	42-50	atrophin 1	Homo sapiens	21-26
10329734-5	1999	Variations in the side chain size and charge of this residue did not inhibit the specific activity of the H,K-ATPase, but reversal of the side chain charge by substitution of Lys or Arg for Glu produced a reciprocal change in the sensitivity of the H,K-ATPase to K+ and SCH 28080.	Arginine	182-185	dynein axonemal heavy chain 8	Homo sapiens	253-259
10329734-6	1999	The K0.5 for K+stimulated ATPase was decreased to 0.2 +/-.05 and 0.2 +/-.03 mM, respectively, in Lys-857 and Arg-857 site mutants, whereas the Ki for SCH 28080-dependent inhibition was increased to 6.5 +/- 1.4 and 5.9 +/- 1.5 microM, respectively.	Arginine	109-112	dynein axonemal heavy chain 8	Homo sapiens	26-32
11674467-6	1999	The two-carbon L-arginine homologue (9), prepared from L-phenylalanine, demonstrated the greatest isoform selective inhibition of the compounds examined (IC(50)(iNOS) = 19 and IC(50)(nNOS) = 147 &amp;mgr;M, IC(50)(nNOS)/IC(50)i(NOS) = 7.7).	Arginine	15-25	nitric oxide synthase 1	Homo sapiens	183-187
11674467-6	1999	The two-carbon L-arginine homologue (9), prepared from L-phenylalanine, demonstrated the greatest isoform selective inhibition of the compounds examined (IC(50)(iNOS) = 19 and IC(50)(nNOS) = 147 &amp;mgr;M, IC(50)(nNOS)/IC(50)i(NOS) = 7.7).	Arginine	15-25	nitric oxide synthase 1	Homo sapiens	214-218
10799519-6	2000	Based on these results, it was concluded that IL-13R112D interacts with much stronger affinity than wtIL-13 on all cell types tested and that Arg-112 plays an important role in the interaction with its receptors (IL-13R).	Arginine	142-145	interleukin 13 receptor subunit alpha 2	Homo sapiens	213-219
10820009-6	2000	Methylation of Arg 106 in bovine MBP (Arg 107 in human), a naturally occurring modification of MBP, has been shown to affect the deimination of arginyl residues in the present study.	Arginine	15-18	myelin basic protein	Homo sapiens	95-98
12962541-9	2004	The computed simulations detailing the docking of Pi1 peptides on to the Kv1.2 channels support an unexpected key role of specific basic amino acid residues, which form a basic ring (Arg-5, Arg-12, Arg-28 and Lys-31 residues), in toxin binding.	Arginine	190-193	Pancreas inflammation QTL 1	Rattus norvegicus	50-53
10320343-4	1999	In the fulminant form of MS, known as Marburg"s Disease, 18 of the 19 arginines in MBP are citrullinated (MBP Cit18).	Arginine	70-79	myelin basic protein	Homo sapiens	83-86
10320343-4	1999	In the fulminant form of MS, known as Marburg"s Disease, 18 of the 19 arginines in MBP are citrullinated (MBP Cit18).	Arginine	70-79	myelin basic protein	Homo sapiens	106-109
12962541-9	2004	The computed simulations detailing the docking of Pi1 peptides on to the Kv1.2 channels support an unexpected key role of specific basic amino acid residues, which form a basic ring (Arg-5, Arg-12, Arg-28 and Lys-31 residues), in toxin binding.	Arginine	190-193	Pancreas inflammation QTL 1	Rattus norvegicus	50-53
10320343-12	1999	We postulate that the generation of MBP peptides, including those that are dominant and encephalitogenic, is directly related to deimination of arginine to citrulline in MBP.	Arginine	144-152	myelin basic protein	Homo sapiens	36-39
15090903-2	2004	However, other important aspects of arginine metabolism, such as arginine transport and arginine catabolism via the arginases, arginine decarboxylase or agmatinase, have been less well studied.	Arginine	36-44	agmatinase	Homo sapiens	153-163
10320343-12	1999	We postulate that the generation of MBP peptides, including those that are dominant and encephalitogenic, is directly related to deimination of arginine to citrulline in MBP.	Arginine	144-152	myelin basic protein	Homo sapiens	170-173
11593518-4	1999	RESULTS: The results showed that dietary L-arginine supplementation reduced expression of VCAM-1 in protein level and mRNA level.	Arginine	41-51	vascular cell adhesion molecule 1	Rattus norvegicus	90-96
10820009-6	2000	Methylation of Arg 106 in bovine MBP (Arg 107 in human), a naturally occurring modification of MBP, has been shown to affect the deimination of arginyl residues in the present study.	Arginine	38-41	myelin basic protein	Homo sapiens	95-98
11593518-5	1999	CONCLUSION: Inhibitory effect of dietary supplementation of L-arginine on VCAM-1 expression may be one of the mechanisms of its antiatherosclerosis.	Arginine	60-70	vascular cell adhesion molecule 1	Rattus norvegicus	74-80
10904848-3	2000	NO is synthesized from L-arginine by the enzyme nitric oxide synthase (NOS).	Arginine	23-33	nitric oxide synthase 1, neuronal	Mus musculus	48-69
14688153-2	2004	NO is formed from L-arginine by isoforms of nitric oxide synthase (NOS) via NG-hydroxy-L-arginine, with L-citrulline as a byproduct.	Arginine	18-28	nitric oxide synthase 1, neuronal	Mus musculus	44-65
10802655-4	2000	The ability of mutant p53 to bind p73, neutralize p73-induced apoptosis and transform cells in cooperation with EJ-Ras was enhanced when codon 72 encoded Arg.	Arginine	154-157	tumor protein p73	Homo sapiens	34-37
10802655-4	2000	The ability of mutant p53 to bind p73, neutralize p73-induced apoptosis and transform cells in cooperation with EJ-Ras was enhanced when codon 72 encoded Arg.	Arginine	154-157	tumor protein p73	Homo sapiens	50-53
10206953-2	1999	Here we report that the mutation of these residues in Kv1.1 to leucine, proline, or arginine abolished the expression of outward potassium currents in Xenopus oocytes.	Arginine	84-92	potassium channel, voltage gated shaker related subfamily A, member 1 S homeolog	Xenopus laevis	54-59
15159657-8	2004	Genetic molecular analysis confirmed this diagnosis by demonstrating that the affected child was homozygous for a novel missense mutation 793A&gt;G, substituting glutamine by arginine (Q238R) in exon 7 of the CACT gene.	Arginine	175-183	solute carrier family 25 member 20	Homo sapiens	209-213
10092618-2	1999	The mutation substitutes an arginine for a leucine at amino acid position 156 in ATPase 6, a component of the F0 portion of the mitochondrial ATP synthase complex.	Arginine	28-36	mitochondrially encoded ATP synthase 6	Homo sapiens	81-89
10777524-2	2000	Thrombin converts TAFI to a carboxypeptidase B-like enzyme (TAFIa) by cleaving at Arg(92) in a process accelerated by the cofactor, thrombomodulin.	Arginine	82-85	carboxypeptidase B2	Homo sapiens	18-22
10887930-9	2000	The two transition mutations observed in the two families also predict the conversion of arginine to a stop codon (R203X and R240X, respectively) around the homeodomain (HD), leading to the truncation of the PAX6 protein within its glycine-rich region.	Arginine	89-97	paired box 6	Homo sapiens	208-212
14665961-1	2004	PURPOSE: Arginase shares the common substrate L-arginine with nitric oxide synthase (NOS).	Arginine	46-56	nitric oxide synthase, brain	Oryctolagus cuniculus	62-83
10830991-9	2000	CGA (Arg, wild type) to TGA (term.)	Arginine	5-8	T-box transcription factor 1	Homo sapiens	24-27
10207276-4	1999	In the present study, utilizing the push-pull perfusion technique of rat hypothalamus, we examined the effect of L-arginine (L-Arg), an NO donor, on the release of GnRH, neuropeptide Y and cyclic GMP (c-GMP), which is a pivotal second messenger molecule of the NO system.	Arginine	113-123	gonadotropin releasing hormone 1	Homo sapiens	164-168
10207276-4	1999	In the present study, utilizing the push-pull perfusion technique of rat hypothalamus, we examined the effect of L-arginine (L-Arg), an NO donor, on the release of GnRH, neuropeptide Y and cyclic GMP (c-GMP), which is a pivotal second messenger molecule of the NO system.	Arginine	113-123	pyroglutamylated RFamide peptide	Rattus norvegicus	170-182
10207276-4	1999	In the present study, utilizing the push-pull perfusion technique of rat hypothalamus, we examined the effect of L-arginine (L-Arg), an NO donor, on the release of GnRH, neuropeptide Y and cyclic GMP (c-GMP), which is a pivotal second messenger molecule of the NO system.	Arginine	125-130	gonadotropin releasing hormone 1	Homo sapiens	164-168
10207276-4	1999	In the present study, utilizing the push-pull perfusion technique of rat hypothalamus, we examined the effect of L-arginine (L-Arg), an NO donor, on the release of GnRH, neuropeptide Y and cyclic GMP (c-GMP), which is a pivotal second messenger molecule of the NO system.	Arginine	125-130	pyroglutamylated RFamide peptide	Rattus norvegicus	170-182
10694430-10	2000	A lysine to arginine mutation abolished MITF (K201R) degradation by hUBC9 in vivo.	Arginine	12-20	ubiquitin conjugating enzyme E2 I	Homo sapiens	68-73
14691231-4	2004	The AMP binding site of the gamma(1) CBS1/CBS2 pair, modeled on the structures of the CBS sequences present in the inosine monophosphate dehydrogenase crystal structure, contains three arginine residues 70, 152, and 171 and His151.	Arginine	185-193	Cbs2p	Saccharomyces cerevisiae S288C	42-46
10694439-0	2000	Single amino acid (arginine) deprivation induces G1 arrest associated with inhibition of cdk4 expression in cultured human diploid fibroblasts.	Arginine	19-27	cyclin dependent kinase 4	Homo sapiens	89-93
10694439-6	2000	These results suggest that arginine deprivation-in common with other "suboptimal" conditions-inhibits the passage of normal human cells through the restriction point and implicate cdk4 as the key regulatory element in amino acid-sensitive cell cycle control.	Arginine	27-35	cyclin dependent kinase 4	Homo sapiens	180-184
10220306-13	1999	We conclude that during sepsis, the NO scavenger PHP unmasks an underlying ET-1 mediated vasoconstriction, and its effect is antagonized by L-arginine and bosentan.	Arginine	140-150	EDN1	Ovis aries	75-79
14681590-2	2004	The aptazyme ligase is activated &gt; 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs.	Arginine	97-105	Rev	Human immunodeficiency virus 1	93-96
10704360-5	2000	These results confirm that the arginine residue at position 55 is critical for intracellular targeting of M-PMV Gag molecules and support the concept that as part of a cytoplasmic transport retention signal R55 interacts with cellular trafficking components rather than other regions of Gag.	Arginine	31-39	Pr78	Mason-Pfizer monkey virus	112-115
10704360-5	2000	These results confirm that the arginine residue at position 55 is critical for intracellular targeting of M-PMV Gag molecules and support the concept that as part of a cytoplasmic transport retention signal R55 interacts with cellular trafficking components rather than other regions of Gag.	Arginine	31-39	Pr78	Mason-Pfizer monkey virus	287-290
10694390-6	2000	Furthermore, substitution of the conserved arginine residue in domain 3 (R435) or in domain 9 (R1334) with alanine resulted in a similar &gt;1000-fold decrease in the affinity for the lysosomal enzyme, beta-glucuronidase.	Arginine	43-51	glucuronidase beta	Homo sapiens	202-220
14681590-2	2004	The aptazyme ligase is activated &gt; 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs.	Arginine	97-105	Rev	Human immunodeficiency virus 1	156-159
14681590-2	2004	The aptazyme ligase is activated &gt; 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs.	Arginine	202-210	Rev	Human immunodeficiency virus 1	93-96
14681590-2	2004	The aptazyme ligase is activated &gt; 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs.	Arginine	202-210	Rev	Human immunodeficiency virus 1	156-159
15954198-4	2004	NO is formed from L-arginine by nitric oxide synthase (NOS).	Arginine	18-28	nitric oxide synthase 1	Homo sapiens	32-53
10677373-3	2000	One allele of the rfc gene contains a point mutation resulting in a Gly(345)--&gt;Arg substitution in the predicted amino acid sequence.	Arginine	82-85	solute carrier family 19 member 1	Homo sapiens	18-21
10759708-4	2000	TAFI can be activated by thrombin, and in its activated form potently attenuates fibrinolysis by removing C-terminal lysine and arginine residues that are important for the binding and activation of plasminogen.	Arginine	128-136	carboxypeptidase B2	Homo sapiens	0-4
10767182-6	2000	It is a C --&gt; T transition at position 508 of the cDNA (c.508 C --&gt; T) that changes the CGA codon for Arg(169) to the TGA stop codon (R169X).	Arginine	108-111	T-box transcription factor 1	Homo sapiens	124-127
14639006-4	2003	The glutamine residue located in the pore-forming segment of GluR2 subunit (Q/R site) is changed to arginine by RNA editing at the pre mRNA stage in normal adult mammalian animal.	Arginine	100-108	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	61-66
14504257-0	2003	L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats.	Arginine	0-10	neutrophil cytosolic factor 1	Rattus norvegicus	20-27
14504257-7	2003	Western blot analyses after subcellular fractionation revealed that l-arginine supplementation distinctly decreases membrane localization of p47phox protein, as it decreases total expression of Rac1 protein in DS rats with high salt loading.	Arginine	68-78	neutrophil cytosolic factor 1	Rattus norvegicus	141-148
14504257-7	2003	Western blot analyses after subcellular fractionation revealed that l-arginine supplementation distinctly decreases membrane localization of p47phox protein, as it decreases total expression of Rac1 protein in DS rats with high salt loading.	Arginine	68-78	Rac family small GTPase 1	Rattus norvegicus	194-198
14629468-3	2003	Results of these studies indicate that in the presence of FX (1.5 micro m), the enzyme (active-site-inhibited Glu-Gly-Arg-FIXa, EGR-FIXa) and procofactor (FVIII) bind to an equal number (approximately 700 sites/platelet) of receptors whereas the active cofactor (FVIIIa) binds an additional approximately 500 high-affinity FVIIIa binding sites per platelet (Kd approximately 0.8 nm).	Arginine	118-121	coagulation factor VIII	Homo sapiens	155-160
12920122-7	2003	Mutation of the Vav1 SH2 domain phosphotyrosine coordinating Arg-696 did not alter Mer/Vav1 constitutive binding or Vav1 tyrosine phosphorylation but did retard Vav1 release from autophosphorylated Mer.	Arginine	61-64	vav guanine nucleotide exchange factor 1	Homo sapiens	16-20
12923240-11	2003	The main roles of AI are regulation of arginine concentration by degrading arginine and production of ornithine for polyamine biosynthesis, but AI may not be the principal enzyme for regulating glutamate biosynthesis in tissues and cells.	Arginine	75-83	arginase, liver	Mus musculus	18-20
14577379-7	2003	The fifth amino acid residue of MCDP in A. cerana cerana and P. hebraeus is arginine, replacing the cysteine, an important disulfide bridges element, in the position as in A. mellifera ligustica.	Arginine	76-84	mast cell degranulating peptide	Apis mellifera	32-36
10758347-1	2000	Decreased nitric oxide synthase (NOS)-catalyzed formation of NO from L-arginine may be involved in ethanol teratogenesis involving the hippocampus.	Arginine	69-79	nitric oxide synthase, inducible	Cavia porcellus	10-31
10762003-6	2000	In HLMC preparations expressing beta2-adrenoceptors with arg (wild-type) or gly (mutant) at position 16, desensitization was 71 +/- 5% (n = 18) or 43 +/- 5%, (n = 26), respectively, whereas the desensitization was 59 +/- 6% (n = 28) for heterozygotes at this position.	Arginine	57-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	32-37
11798760-10	2000	However, mPAP was significantly decreased in hypoxic rats treated with L-arginine (2.23 kPa +/- 0.18 kPa) as compared with that of hypoxic rats (2.71 kPa +/- 0.29 kPa) (P &lt; 0.05).	Arginine	71-81	phospholipid phosphatase 1	Mus musculus	9-13
10686338-4	2000	The expression of nitric oxide synthase (NOS) which catalyzes the formation of a similar neurotransmitter nitric oxide (NO) from arginine is increased in the spinal cords of animals chronically exposed to morphine and other opioids.	Arginine	129-137	nitric oxide synthase 1, neuronal	Mus musculus	18-39
10652317-9	2000	The three-dimensional structure of ligand-free hGSTM2-2 determined by x-ray crystallography suggests that Arg(107) maintains an electrostatic interaction with the Asp(161) side chain (3 A apart), but is distant from the GSH-binding site.	Arginine	106-109	glutathione S-transferase mu 2	Homo sapiens	47-55
10675299-2	2000	Reduction in cationicity of MBP, especially due to conversion of positively charged arginine residues to uncharged citrulline (Cit), has been found to be associated with multiple sclerosis (MS).	Arginine	84-92	myelin basic protein	Homo sapiens	28-31
10652159-8	2000	These anti-ssDNA reactive monoclonal antibodies had basic amino acids in the VH-CDR3, strongly supporting the suggested role of arginine in DNA binding.	Arginine	128-136	CDR3	Homo sapiens	80-84
10688364-3	2000	For example, at the R/G editing site of gluR-B, -C, and -D RNAs, ADARs change an arginine codon (AGA) to a glycine codon (IGA) so that two protein isoforms can be synthesized from a single encoded mRNA; the highly related gluR-A sequence is not edited at this site.	Arginine	81-89	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	40-46
10673352-1	2000	The human CD23 molecule (low affinity receptor for IgE) has a C-type lectin domain, a reversed Arg-Gly-Asp (RGD) sequence near the C-terminus, and an "RGD-binding inhibitory peptide" at the root of the N-sugar chain.	Arginine	95-98	Fc epsilon receptor II	Homo sapiens	10-14
10086391-1	1999	Nitric oxide (NO) is an ubiquitous signaling molecule produced from L-arginine by NO synthase (NOS).	Arginine	68-78	nitric oxide synthase 1, neuronal	Mus musculus	82-93
10026272-3	1999	NO bound quickly to ferrous nNOS oxygenase to form a six-coordinate NO complex (kon and koff values of 1.25 x 10(-)3 mM-1 s-1 and 128 s-1 at 10 degreesC, respectively) that was stable in the presence of L-arginine or tetrahydrobiopterin (BH4) but was converted to a five-coordinate NO complex in a biphasic process (k = 0.1 and 0.01 s-1 at 10 degreesC) in the absence of these molecules.	Arginine	203-213	nitric oxide synthase 1	Homo sapiens	28-32
10026272-6	1999	Incubation of ferric P420 nNOS with BH4 alone or BH4 and L-arginine resulted in time-dependent reactivation of catalysis and associated recovery of P450 character.	Arginine	57-67	nitric oxide synthase 1	Homo sapiens	26-30
10026272-6	1999	Incubation of ferric P420 nNOS with BH4 alone or BH4 and L-arginine resulted in time-dependent reactivation of catalysis and associated recovery of P450 character.	Arginine	57-67	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	148-152
9876120-6	1999	Decomposition of the RTA-RNA binding free energy into individual contributions revealed the electrostatic "hot" spots arising from charge-charge complementarity of the interfacial arginines with the RNA phosphate backbone.	Arginine	180-189	RNA binding fox-1 homolog 2	Homo sapiens	21-24
9892224-10	1999	Islets stimulated by glucose or L-arginine displayed a marked increase in their NO-synthase (NOS) activity.	Arginine	32-42	nitric oxide synthase 1, neuronal	Mus musculus	80-91
9882595-7	1999	TA1 expression increased in media without arginine and glutamine and was repressed by total amino acid levels 5-fold over basal MEM.	Arginine	42-50	solute carrier family 7 member 5	Rattus norvegicus	0-3
9857005-5	1998	In contrast to wild-type nNOS (WT-nNOS), which exhibits an absorbance maximum at 407 nm that shifts immediately upon L-arginine addition to a high spin form, the C331A-nNOS mutant, as isolated, exhibited an absorbance maximum at 420 nm.	Arginine	117-127	nitric oxide synthase 1	Homo sapiens	25-29
9857005-5	1998	In contrast to wild-type nNOS (WT-nNOS), which exhibits an absorbance maximum at 407 nm that shifts immediately upon L-arginine addition to a high spin form, the C331A-nNOS mutant, as isolated, exhibited an absorbance maximum at 420 nm.	Arginine	117-127	nitric oxide synthase 1	Homo sapiens	34-38
9857005-5	1998	In contrast to wild-type nNOS (WT-nNOS), which exhibits an absorbance maximum at 407 nm that shifts immediately upon L-arginine addition to a high spin form, the C331A-nNOS mutant, as isolated, exhibited an absorbance maximum at 420 nm.	Arginine	117-127	nitric oxide synthase 1	Homo sapiens	34-38
9857005-9	1998	The estimated Kd for L-arginine binding to C331A-nNOS was two orders of magnitude greater than WT-nNOS (&gt;100 microM versus 2-3 microM).	Arginine	21-31	nitric oxide synthase 1	Homo sapiens	49-53
9857005-9	1998	The estimated Kd for L-arginine binding to C331A-nNOS was two orders of magnitude greater than WT-nNOS (&gt;100 microM versus 2-3 microM).	Arginine	21-31	nitric oxide synthase 1	Homo sapiens	98-102
9857005-10	1998	Here we propose that Cys331 plays an important role in stabilizing L-arginine binding to nNOS.	Arginine	67-77	nitric oxide synthase 1	Homo sapiens	89-93
9857005-12	1998	Prolonged incubation with L-arginine appears to cause remodeling of the mutant protein to a form similar to that of WT-nNOS, allowing for normalized BH4 binding and nitric oxide synthetic activity.	Arginine	26-36	nitric oxide synthase 1	Homo sapiens	119-123
9886302-3	1998	The patient with type II was homozygous for a C-to-T substitution in codon 8 3 that changes Arg (CGA) to a stop codon (TGA), resulting in a truncated b5R without the catalytic portion.	Arginine	92-95	T-box transcription factor 1	Homo sapiens	119-122
9886302-3	1998	The patient with type II was homozygous for a C-to-T substitution in codon 8 3 that changes Arg (CGA) to a stop codon (TGA), resulting in a truncated b5R without the catalytic portion.	Arginine	92-95	cytochrome b5 reductase 3	Homo sapiens	150-153
9834112-8	1998	Both the phagocytosis and production of the cytokines were suppressed by either phospho-L-serine or RGDS (Arg-Gly-Asp-Ser), but not by RGES (Arg-Gly-Glu-Ser).	Arginine	106-109	ral guanine nucleotide dissociation stimulator	Homo sapiens	100-104
9864293-5	1998	These results suggest that inhibition of nNOS activity is due to direct binding of the compound to the L-arginine binding site of the synthase.	Arginine	103-113	nitric oxide synthase 1	Homo sapiens	41-45
9819200-9	1998	Replacement of the arginine-9 position with a proline decreases binding affinity to ACA 10-fold.	Arginine	19-27	small nucleolar RNA, H/ACA box 10	Homo sapiens	84-90
12777403-5	2003	However, a positively charged arginine residue is present in the transmembrane region of the DCAR, which may explain its association with Fc receptor gamma chain and its stable expression on the cell surface.	Arginine	30-38	Fc epsilon receptor Ig	Homo sapiens	138-161
9804899-2	1998	The majority of L-arginine flux is mediated by transport system y+ that is encoded by at least three genes, Cat1, Cat2 and Cat3.	Arginine	16-26	solute carrier family 7 member 2	Homo sapiens	114-118
9804899-7	1998	Activated macrophages decreased CAT1 levels, but accumulated CAT2 and iNOS mRNA and protein with parallel kinetics suggesting that CAT2 mediated L-arginine transport might regulate the L-arginine:nitric oxide pathway.	Arginine	145-155	solute carrier family 7 member 2	Homo sapiens	61-65
9804899-7	1998	Activated macrophages decreased CAT1 levels, but accumulated CAT2 and iNOS mRNA and protein with parallel kinetics suggesting that CAT2 mediated L-arginine transport might regulate the L-arginine:nitric oxide pathway.	Arginine	145-155	solute carrier family 7 member 2	Homo sapiens	131-135
10620501-6	2000	A 12-residue spacer, Thr-Arg-His-Arg-Gln-Pro-Arg-Gly-Trp-Glu-Gln-Leu, containing the recognition site for the protease furin, was incorporated between the toxin and the ligand to generate restrictocin-spacer-anti-TFR(scFv) and anti-TFR(scFv)-spacer-restrictocin.	Arginine	25-28	furin, paired basic amino acid cleaving enzyme	Homo sapiens	119-124
10620501-6	2000	A 12-residue spacer, Thr-Arg-His-Arg-Gln-Pro-Arg-Gly-Trp-Glu-Gln-Leu, containing the recognition site for the protease furin, was incorporated between the toxin and the ligand to generate restrictocin-spacer-anti-TFR(scFv) and anti-TFR(scFv)-spacer-restrictocin.	Arginine	33-36	furin, paired basic amino acid cleaving enzyme	Homo sapiens	119-124
10625554-7	2000	The mutant Hd protein (HOXA13(Hd)) consists of the first 25 amino acids of wild-type HOXA13 sequence, followed by 275 amino acids of arginine- and lysine-rich, novel sequence, and lacks the homeodomain.	Arginine	133-141	homeobox A13	Mus musculus	23-29
9804899-7	1998	Activated macrophages decreased CAT1 levels, but accumulated CAT2 and iNOS mRNA and protein with parallel kinetics suggesting that CAT2 mediated L-arginine transport might regulate the L-arginine:nitric oxide pathway.	Arginine	185-195	solute carrier family 7 member 2	Homo sapiens	131-135
9811877-1	1998	Calcium permeability of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which carries an arginine (R) residue at a critical site of the channel pore.	Arginine	210-218	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	90-96
12899627-5	2003	Both human and murine C5L2 bear a leucine for arginine replacement at this site.	Arginine	46-54	complement component 5a receptor 2	Mus musculus	22-26
9811877-1	1998	Calcium permeability of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which carries an arginine (R) residue at a critical site of the channel pore.	Arginine	94-95	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	177-183
12899627-9	2003	Biophysical properties of the C5L2, including slow ligand on and off rates, absence of internalization, and relatively high affinity for the C5a des Arg metabolite, suggest that this receptor may serve to modulate C5a biological functions in vivo.	Arginine	149-152	complement component 5a receptor 2	Mus musculus	30-34
9858782-0	1998	Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase.	Arginine	24-27	prolyl 4-hydroxylase subunit beta	Bos taurus	68-95
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Arginine	85-88	gonadotropin releasing hormone 1	Homo sapiens	0-30
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Arginine	137-140	prolyl 4-hydroxylase subunit beta	Bos taurus	44-71
11255560-1	2000	Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.	Arginine	85-88	gonadotropin releasing hormone 1	Homo sapiens	32-36
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	177-180	coagulation factor VIII	Homo sapiens	14-25
9858782-15	1998	These results suggest that endothelial cell derived protein disulfide isomerase may regulate Arg-Gly-Asp-dependent binding of thrombospondin-1.	Arginine	93-96	prolyl 4-hydroxylase subunit beta	Bos taurus	52-79
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	177-180	coagulation factor VIII	Homo sapiens	27-32
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor VIII	Homo sapiens	14-25
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor VIII	Homo sapiens	27-32
9833037-8	1998	The same arginine position has been mutated in the keratin 10 gene in epidermolytic hyperkeratosis, the keratin 14 gene in epidermolysis bullosa simplex, and the keratin 9 gene in hereditary EPPK in Western patients.	Arginine	9-17	keratin 1	Homo sapiens	191-195
10611379-0	1999	pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.	Arginine	53-56	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	13-17
10611379-0	1999	pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome.	Arginine	61-64	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	13-17
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor VIII	Homo sapiens	14-25
12689334-1	2003	Activation of factor VIII (FVIII) by thrombin plays a fundamental role in the amplification of the coagulation cascade and takes place through specific proteolytic cleavages at Arg(372), Arg(740) and Arg(1689).	Arginine	187-190	coagulation factor VIII	Homo sapiens	27-32
12689334-2	2003	Full FVIII activation requires cleavage at Arg(372), a process involving the alpha-thrombin exosite-II; referred to as heparin-binding site (HBS).	Arginine	43-46	coagulation factor VIII	Homo sapiens	5-10
9786970-6	1998	At a holding potential of -100 mV, the inward current through Kir7.1 averaged -3.8 +/- 1.04 microA with 2 mM [K+]e and -4.82 +/- 1.87 microA with 96 mM [K+]e. Kir7.1 has a methionine at position 125 in the pore region where other Kir channels have an arginine.	Arginine	251-259	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	62-65
12689334-6	2003	Furthermore, SDS/PAGE and Western-blot experiments showed that the specific appearance of the 44 kDa A2 domain on cleavage of the FVIII Arg(372)-Ser(373) peptide bond was delayed significantly in the presence of either GpIbalpha 1-282 or GpIb 268-282 peptide.	Arginine	136-139	coagulation factor VIII	Homo sapiens	130-135
9786970-7	1998	When this residue was replaced by the conserved arginine in mutant Kir7.1 channels, the pronounced dependence of K+ permeability on [K+]e, characteristic for other Kir channels, was restored and the Ba2+ sensitivity was increased by a factor of approximately 25 (Ki = 27 microM).	Arginine	48-56	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	67-70
12734181-2	2003	The binding of CaM is mediated in part by the electrostatic interaction between residues Arg-464 and Lys-467 of SK2 and Glu-84 and Glu-87 of CaM.	Arginine	89-92	sphingosine kinase 2	Homo sapiens	112-115
10047984-10	1998	Similar to MLCK, Arg-16 is required for interaction of gamma-PAK with the substrate, since converting Arg-16 to Ala significantly reduced RLC phosphorylation.	Arginine	17-20	p21 (RAC1) activated kinase 2	Homo sapiens	55-64
12832612-3	2003	We began with a modified eglin c, Arg-42-Arg-45-eglin, in which the reactive site loop had been optimized for subtilisin-related processing proteases of the Kex2/furin family.	Arginine	34-37	furin, paired basic amino acid cleaving enzyme	Homo sapiens	162-167
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Arginine	20-23	furin, paired basic amino acid cleaving enzyme	Homo sapiens	70-75
9756558-3	1998	Both arginase and ODC are enzymes involved in the conversion of arginine to polyamines required for cell proliferation.	Arginine	64-72	ornithine decarboxylase 1	Homo sapiens	18-21
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Arginine	20-23	furin, paired basic amino acid cleaving enzyme	Homo sapiens	88-93
9739019-8	1998	DNA sequencing revealed that exon 13 of the second hMSH2 allele contains a base substitution at codon 711, which changes an arginine to a termination codon (CGA--&gt;TGA).	Arginine	124-132	mutS homolog 2	Homo sapiens	51-56
9739019-8	1998	DNA sequencing revealed that exon 13 of the second hMSH2 allele contains a base substitution at codon 711, which changes an arginine to a termination codon (CGA--&gt;TGA).	Arginine	124-132	T-box transcription factor 1	Homo sapiens	166-169
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Arginine	27-30	furin, paired basic amino acid cleaving enzyme	Homo sapiens	70-75
12832612-7	2003	One variant, Asp-49-Arg-42-Arg-45-eglin, exhibited a Ki of 310 pM for furin and blocked furin-dependent processing of von Willebrand factor in COS-1 cells when added to the culture medium of the cells.	Arginine	27-30	furin, paired basic amino acid cleaving enzyme	Homo sapiens	88-93
12883629-5	2003	As the result, a novel SNP A(+884)-->G within the sixth exon of HL gene was found, the 276 codon AAA was changed into AGA and resulted in the substitution of arginine for lysine.	Arginine	158-166	lipase C, hepatic type	Homo sapiens	64-66
9798984-5	1998	An average of four of the total nineteen Arg residues in alpha2AP reacted with phenylglyoxal and resulted in complete loss of plasmin inhibitory activity; however, mod alpha2AP competed effectively with native alpha2AP for becoming crosslinked to fibrin by FXIIIa catalysis.	Arginine	41-44	plasminogen	Homo sapiens	126-133
9888514-2	1998	NO is synthesised from arginine, by a family of Nitric Oxide Synthase (NOS).	Arginine	23-31	nitric oxide synthase 1, neuronal	Mus musculus	48-69
12771999-1	2003	[Arg(6),D-Trp(7,9),N(me)Phe(8)]-substance P (6-11) (SP-G) is a novel anticancer agent that has recently completed phase I clinical trials.	Arginine	1-4	surfactant associated 2	Homo sapiens	52-56
9648928-8	1998	However, mRNA levels for GTP cyclohydrolase I, a key enzyme in (6R)-tetrahydro-L-biopterin synthesis, and cationic amino acid transporter-2, involved in L-arginine transport, was enhanced in cells overexpressing PKCalpha compared with control cells.	Arginine	153-163	GTP cyclohydrolase 1	Homo sapiens	25-45
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Arginine	131-139	plasminogen	Homo sapiens	31-38
9668083-7	1998	In vitro binding assays show that the glycine-arginine rich domain of nucleolin (RGG domain) is sufficient for the interaction with one of these proteins.	Arginine	46-54	nucleolin	Rattus norvegicus	70-79
9632678-5	1998	In addition, we have replaced the conserved arginine (Arg305), which was suggested by structural studies to be a key catalytic residue, with an alanine and found that the R305A Cdc42-GAP mutant has a greatly diminished catalytic capacity but is still able to bind Cdc42 with high affinity.	Arginine	44-52	cell division cycle 42	Homo sapiens	177-182
9642058-0	1998	A superrepressor mutant of the arginine repressor with a correctly predicted alteration of ligand binding specificity.	Arginine	31-39	repressor	Escherichia coli	7-16
9642058-1	1998	Arginine biosynthesis in Escherichia coli is negatively regulated by the hexameric repressor protein ArgR and the corepressor L-arginine.	Arginine	0-8	repressor	Escherichia coli	83-92
9642058-2	1998	L-Arginine binds to ArgR in the C-terminal domain of the repressor.	Arginine	0-10	repressor	Escherichia coli	57-66
14567541-2	2003	Once activated, by thrombin or plasmin, TAFI down regulates fibrinolysis, slowing clot lysis by cleaving the C-terminal lysine and arginine residues from partially degraded fibrin.	Arginine	131-139	carboxypeptidase B2	Homo sapiens	40-44
9654140-1	1998	The stimulatory effects of several DNA-binding basic proteins (histone and protamine) and HIV-1 Rev with arginine (Arg)-rich clusters on the activity of casein kinase II (CK-II) were investigated in vitro.	Arginine	105-113	Rev	Human immunodeficiency virus 1	96-99
12756295-7	2003	Furthermore, estrogen-responsive gene expression was aberrant in Carm1-/- fibroblasts and embryos, thus emphasizing the role of arginine methylation as a transcription activation tag.	Arginine	128-136	coactivator-associated arginine methyltransferase 1	Mus musculus	65-70
9654140-1	1998	The stimulatory effects of several DNA-binding basic proteins (histone and protamine) and HIV-1 Rev with arginine (Arg)-rich clusters on the activity of casein kinase II (CK-II) were investigated in vitro.	Arginine	115-118	Rev	Human immunodeficiency virus 1	96-99
9654140-2	1998	It was found that recombinant Rev (rRev) and the synthetic oligo-fragments corresponding to the amino acid sequences of its Arg-rich cluster stimulate CK-II activity in a dose-dependent manner.	Arginine	124-127	Rev	Human immunodeficiency virus 1	30-33
12727869-6	2003	Pos5p is localized to the mitochondrial matrix of yeast and appears to be important for several NADPH-requiring processes in the mitochondria, including resistance to a broad range of oxidative stress conditions, arginine biosynthesis and mitochondrial iron homeostasis.	Arginine	213-221	NADH kinase	Saccharomyces cerevisiae S288C	0-5
9585533-2	1998	Indeed, cloning of rhesus monkey apo(a) has shown that a Trp72 --&gt; Arg mutation in the lysine-binding site (LBS) of KIV-10 leads to loss of lysine-binding properties of the rhesus Lp(a) particle.	Arginine	70-73	apolipoprotein(a)	Macaca mulatta	183-188
9575164-1	1998	The soluble human transferrin receptor (TfR) found in blood is the result of a proteolytic cleavage occurring in the ectodomain of the receptor close to the transmembrane domain at Arg-100.	Arginine	181-184	transferrin receptor	Homo sapiens	18-38
9575164-1	1998	The soluble human transferrin receptor (TfR) found in blood is the result of a proteolytic cleavage occurring in the ectodomain of the receptor close to the transmembrane domain at Arg-100.	Arginine	181-184	transferrin receptor	Homo sapiens	40-43
12737817-3	2003	Here we describe the crystal structure of rat PRMT1 in complex with the reaction product AdoHcy and a 19 residue substrate peptide containing three arginines.	Arginine	148-157	protein arginine methyltransferase 1	Rattus norvegicus	46-51
9553082-10	1998	In line with this result is the observation that wild-type alkyl-DHAP synthase activity can be inactivated by the arginine-modifying agent phenylglyoxal.	Arginine	114-122	alkylglycerone phosphate synthase	Homo sapiens	59-78
12737819-7	2003	It was suggested that the aptamer structure is similar for both complexes and that the aptamer interacts with two different arginine residues of the peptide simultaneously at the two binding sites, which could explain the high affinity to Tat.	Arginine	124-132	tyrosine aminotransferase	Homo sapiens	239-242
12578822-6	2003	In accordance with the structural model, mutation of Arg(289) or a pair of its interacting partners (Tyr(285) and Asn(293)) abolished C/EBPalpha binding activity.	Arginine	53-56	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	134-144
12578822-7	2003	Val(296) (Ala in most other bZIPs) contributes to C/EBPalpha specificity by discriminating against purines at position -3 and imposing steric restraints on the invariant Arg(300).	Arginine	170-173	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	50-60
9599009-4	1998	These patterns were further extended to other members in each subfamily and the geometry orientation of crucial arginines R789 in p120 and R282 in p50 and of important stabilizing residues like p120R903 and p50N391 was confirmed.	Arginine	112-121	RAS p21 protein activator 1	Homo sapiens	130-134
12726864-3	2003	A polymorphism encoding either arginine (72R) or proline (72P) at codon 72 of p53 influences inhibition of p73 by a range of p53 mutants identified in squamous cancers.	Arginine	31-39	tumor protein p73	Homo sapiens	107-110
9558075-5	1998	An arginine or lysine residue frequently appeared at position alpha93 in the CDR3 of the TCR alpha-chains from Hom-CTL restricted by HLA-A68 or -B8.	Arginine	3-11	CDR3	Homo sapiens	77-81
9558075-5	1998	An arginine or lysine residue frequently appeared at position alpha93 in the CDR3 of the TCR alpha-chains from Hom-CTL restricted by HLA-A68 or -B8.	Arginine	3-11	T cell receptor alpha constant	Homo sapiens	89-98
12615083-0	2003	In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5"-nucleotidase activities from rat brain synaptosomes.	Arginine	20-30	5' nucleotidase, ecto	Rattus norvegicus	71-86
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	96-99	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
12615083-2	2003	In the present study, we investigated the in vitro effects of Arg, NA, AA and HA on NTPDase1 and 5"-nucleotidase activities from synaptosomal cerebral cortex of rats.	Arginine	62-65	5' nucleotidase, ecto	Rattus norvegicus	97-112
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	96-99	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	96-99	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
12675924-3	2003	Cat2 ablation appears to reduce astrocyte NO synthesis by decreasing the uptake of the sole precursor, arginine, as well as by reducing the expression of iNOS following activation.	Arginine	103-111	solute carrier family 7 member 2	Homo sapiens	0-4
9516482-3	1998	In the present study, we analyzed the effects of mutating the Glu at position 31 of the c-Ha-Ras protein to Asp, Ala, Arg, and Lys on the interactions with Raf-1 and RalGDS.	Arginine	118-121	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	156-161
9516482-4	1998	The Ras-binding domain (RBD) of Raf-1 binds the E31R and E31K Ras mutants less tightly than the wild-type, E31A, and E31D Ras proteins; the introduction of the positively charged Lys or Arg residue at position 31 specifically impairs the binding of Ras with the Raf-1 RBD.	Arginine	186-189	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	32-37
12718890-4	2003	Specific arginine residues in SPT5 that are methylated by these enzymes were identified and demonstrated to be important in regulating its promoter association and subsequent effects on transcriptional elongation.	Arginine	9-17	SPT5 homolog, DSIF elongation factor subunit	Homo sapiens	30-34
9516482-4	1998	The Ras-binding domain (RBD) of Raf-1 binds the E31R and E31K Ras mutants less tightly than the wild-type, E31A, and E31D Ras proteins; the introduction of the positively charged Lys or Arg residue at position 31 specifically impairs the binding of Ras with the Raf-1 RBD.	Arginine	186-189	zinc fingers and homeoboxes 2	Homo sapiens	32-35
9497333-7	1998	Active-site alignment of the vanadium-containing chloroperoxidase and G6Pases predicts that Arg-83, His-119, and His-176 in G6Pase contribute to the active site and that His-176 is the residue that covalently binds the phosphoryl moiety during catalysis.	Arginine	92-95	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	70-76
9497333-8	1998	This alignment also predicts that Arg-83, His-119, and His-176 reside on the same side of the endoplasmic reticulum membrane, which is supported by the recently predicted nine-transmembrane helical model for G6Pase.	Arginine	34-37	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	208-214
12609749-7	2003	High concentrations of IAPP, however, inhibited insulin release stimulated by glucose (10 and 16.7 mM), IBMX, carbachol and L-arginine.	Arginine	124-134	islet amyloid polypeptide	Homo sapiens	23-27
9548595-9	1998	Site-directed mutagenesis of basic residues 321, 405, 407, 409, 415, and 416 revealed that Arg 405 is necessary for the interaction of LPL with xCAL 3-6a.	Arginine	91-94	lipoprotein lipase	Bos taurus	135-138
9548595-11	1998	Heparin-Sepharose chromatography of wild-type LPL and a mutant LPL in which the well-characterized heparin-binding sequence (Arg 281-Lys 282-Arg 284) has been mutated was carried out in the presence and absence of xCAL 3-6a.	Arginine	125-128	lipoprotein lipase	Bos taurus	63-66
10632627-3	1999	Arginine for the synthesis of NO, which has a major role in the increase in rCBF, is released from astrocytes in response to stimulation of astrocytic glutamate receptors.	Arginine	0-8	CCAAT/enhancer binding protein zeta	Rattus norvegicus	76-80
12525504-7	2003	Indeed, the effect of polymorphic variation on absolute adenylyl cyclase activities was such that desensitized beta(1)AR-Arg(389) signaling was equivalent to non-desensitized wild-type beta(1)AR; that is, the genetic component had as much impact as desensitization on receptor coupling.	Arginine	121-124	adrenoceptor beta 1	Homo sapiens	111-120
9499091-3	1998	Translation of RNAs in reticulocyte lysates showed that cleavage at the nsP3/nsP4 site occurred efficiently for all mutants except for Glu-nsP4, which was cleaved inefficiently, and Pro-nsP4, which was not detectably cleaved, and that Tyr, Cys, Leu, Arg, and Phe destabilized nsP4 but Ala, Met, Thr, Asn, Gln, and Glu stabilized nsP4 to various extents.	Arginine	250-253	serine protease 57	Homo sapiens	77-81
10585738-3	1999	The plasmin formed from plasminogen by the activators catalyzes the decomposition of the arginine-rich protamine substrate, yielding smaller polycationic fragments that are not sensed by the electrode.	Arginine	89-97	plasminogen	Homo sapiens	4-11
12614157-0	2003	Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.	Arginine	49-57	Rev	Human immunodeficiency virus 1	45-48
10637120-1	1999	In stimulated murine macrophage, arginase and nitric oxide synthase (NOS) compete for their common substrate, l-arginine.	Arginine	110-120	nitric oxide synthase 1, neuronal	Mus musculus	46-67
10589951-9	1999	The lower percentage of increase of insulin release after arginine stimulation observed in the FK-506 and CsA groups as compared with controls (754%+/-100, 644%+/-102 vs. 1191%+/-174) (P&lt;0.03 and 0.02, respectively), suggests a reduced beta cell secretory reserve in both treated groups.	Arginine	58-66	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	95-109
10545100-6	1999	By replacing two arginines conserved between Rab3 isoforms, we generated a mutant with a reduced affinity for calmodulin.	Arginine	17-26	calmodulin 1	Rattus norvegicus	110-120
10622228-5	1999	Additionally, application of the calmodulin inhibitor W-7 (0.01-0.33 nmol) reduced cardiovascular responses to L-arginine (10 nmol) in a dose-dependent manner.	Arginine	111-121	calmodulin 1	Rattus norvegicus	33-43
10479735-4	1999	In the present paper we describe the synthesis, biological evaluation, and conformational characterization of two point-mutated PTH/PTHrP 1-34 hybrids in which the arginine residues at positions 19 and 21 of the native sequence of PTHrP have been replaced by valine (hybrid V(21)) and glutamic acid (hybrid E(19)), respectively, taken from the PTH sequence.	Arginine	164-172	parathyroid hormone like hormone	Homo sapiens	132-137
10479735-4	1999	In the present paper we describe the synthesis, biological evaluation, and conformational characterization of two point-mutated PTH/PTHrP 1-34 hybrids in which the arginine residues at positions 19 and 21 of the native sequence of PTHrP have been replaced by valine (hybrid V(21)) and glutamic acid (hybrid E(19)), respectively, taken from the PTH sequence.	Arginine	164-172	parathyroid hormone like hormone	Homo sapiens	231-236
10496984-0	1999	Matrix localization of tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor (TFPI-2/MSPI) involves arginine-mediated ionic interactions with heparin and dermatan sulfate: heparin accelerates the activity of TFPI-2/MSPI toward plasmin.	Arginine	124-132	plasminogen	Homo sapiens	251-258
10508155-6	1999	The catalytic domains of Gyp1p and Gyp7p contain five invariant arginine residues; substitutions of only one of them (R343 in Gyp1p and R458 in the analogous position of Gyp7p) rendered the GAPs almost completely inactive.	Arginine	64-72	GTPase-activating protein GYP7	Saccharomyces cerevisiae S288C	35-40
10491201-7	1999	Replacement of the His6 residue of alpha-MSH-ND by Gln, Asn, Arg or Lys decreased not only the receptor binding, but also the cAMP-generating activity in both the MC3R and the MC4R.	Arginine	61-64	melanocortin receptor 4	Cricetulus griseus	176-180
10502833-4	1999	All patients were found to be homozygous for a newly identified C -&gt;T transition in codon 21 (exon 2) substituting arginine for a premature stop codon (R21X: CGA to TGA) and generating a NlaIII restriction site.	Arginine	118-126	T-box transcription factor 1	Homo sapiens	168-171
10523035-2	1999	This patient bore a novel point mutation (T for A) at codon 168 of the gene encoding the GnRH receptor (GnRH-R), resulting in a serine to arginine change in the fourth transmembrane domain of the receptor.	Arginine	138-146	gonadotropin releasing hormone receptor	Homo sapiens	89-102
10480954-5	1999	Recombinant granzyme K cleaves synthetic thiobenzyl ester substrates after Lys and Arg with k(cat)/K(m) values of 3.7 x 10(4) and 4.4 x 10(4) M(-1) s(-1), respectively.	Arginine	83-86	granzyme K	Homo sapiens	12-22
10556566-2	1999	Cleavage of the Arg(561)-Val(562) activation site in plasminogen by either tissue- or urokinase-type plasminogen activator results in formation of the fibrinolytic enzyme plasmin.	Arginine	16-19	plasminogen	Homo sapiens	53-60
10556566-5	1999	To investigate if introduction of the Arg-Val activation site in apo(a) might result in sensitivity towards plasminogen activators, we expressed wild-type and Arg-Val mutant recombinant apo(a) [r-apo(a)] in human embryonic kidney and hepatocyte cell lines.	Arginine	38-41	lipoprotein(a)	Homo sapiens	65-71
10449725-2	1999	An arginine-rich alpha-helix from HIV-1 Rev was engineered into the zinc finger framework, and the designed fingers were shown to bind specifically to the RRE with high affinity and in a zinc-dependent manner, and display cobalt absorption and CD spectra characteristic of properly folded fingers.	Arginine	3-11	Rev	Human immunodeficiency virus 1	40-43
10438547-6	1999	To study the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex containing VAMP2 in parotid acinar cells, we prepared rabbit polyclonal antibody against the peptide corresponding to Arg(47)-Asp(64) of VAMP2 (anti-SER4256).	Arginine	234-237	vesicle-associated membrane protein 2	Rattus norvegicus	127-132
10447959-8	1999	The most potent nNOS inhibitor among these compounds is L-Arg(NO)()2-L-Dbu-NH(2) (23) (K(i) = 130 nM), which also exhibits the highest selectivity over eNOS (&gt;1500-fold) with a 192-fold selectivity over iNOS.	Arginine	56-61	nitric oxide synthase 1	Homo sapiens	16-20
10397699-13	1999	Finally, chemical modification of lysine and arginine residues reduced the overall inhibition of tissue factor by TFPI.	Arginine	45-53	tissue factor pathway inhibitor	Homo sapiens	114-118
10417510-3	1999	NO is generated from arginine by NO synthase (NOS); the Ca2+-dependent neuronal isoform or nNOS (expressed by neurones and inhibited by the protein inhibitor of nNOS, PIN), is also expressed by cultured normal melanocytes and by all malignant melanoma (MM) cell lines.	Arginine	21-29	nitric oxide synthase 1	Homo sapiens	33-44
10417510-3	1999	NO is generated from arginine by NO synthase (NOS); the Ca2+-dependent neuronal isoform or nNOS (expressed by neurones and inhibited by the protein inhibitor of nNOS, PIN), is also expressed by cultured normal melanocytes and by all malignant melanoma (MM) cell lines.	Arginine	21-29	nitric oxide synthase 1	Homo sapiens	91-95
10383917-8	1999	In particular, CYP2C19, CYP2B6, CYP2C9-Arg, CYP2D6-Val, and CYP3A4 all showed relatively high activity.	Arginine	39-42	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	24-30
10445389-9	1999	Under load conditions (alanine, arginine or glutamine), EGF pretreatment was followed by a stimulation of renal amino acid reabsorption.	Arginine	32-40	epidermal growth factor like 1	Rattus norvegicus	56-59
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Arginine	92-100	arginase 1	Rattus norvegicus	231-236
10417619-4	1999	As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients.	Arginine	164-172	Fc gamma receptor IIa	Homo sapiens	13-34
10417619-7	1999	Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele.	Arginine	221-229	Fc gamma receptor IIa	Homo sapiens	199-220
12614157-7	2003	Similar results were obtained when BSA molecules with covalently attached Rev-arginine rich motif (ARM) peptides were used as a nuclear transport substrate, indicating that the nuclear import inhibition of the Rev protein is due to the presence of the ARM domain.	Arginine	78-86	Rev	Human immunodeficiency virus 1	74-77
12614157-7	2003	Similar results were obtained when BSA molecules with covalently attached Rev-arginine rich motif (ARM) peptides were used as a nuclear transport substrate, indicating that the nuclear import inhibition of the Rev protein is due to the presence of the ARM domain.	Arginine	78-86	Rev	Human immunodeficiency virus 1	210-213
12604352-1	2003	We previously reported that a missense mutation at codon 121 (CGG(Arg) to TGG(Trp), R121W) of PAX4 may be associated with the onset of type 2 diabetes in Japanese.	Arginine	66-69	paired box 4	Homo sapiens	94-98
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Arginine	18-27	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	124-128
10364171-2	1999	Increases of external pH decrease the single-channel conductance in mutant R148H of the Kir2.1 channel (arginine is mutated into histidine) but not in the wild type channel.	Arginine	104-112	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	88-94
12620851-3	2003	A pro3 ure2 strain expressing a PGK1 promoter-driven PUT2 allele encoding Delta(1)-pyrroline-5-carboxylate dehydrogenase lacking a mitochondrial targeting sequence produced significant cytoplasmic activity, accumulated twice as much intracellular glutamate, and produced twice as much cell mass as the parent when grown anaerobically on limiting arginine as sole nitrogen source.	Arginine	346-354	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	32-36
12708312-2	2003	Enteropeptidase (enterokinase, EC 3.4.21.9) hydrolyzes peptide bonds formed by carboxyl groups of Lys or Arg residue provided that less than four negatively charged amino acid residues are in positions P2-P5 of its substrate.	Arginine	105-108	transmembrane serine protease 15	Homo sapiens	0-15
10369774-2	1999	We have determined the solution structure of the Gly26--&gt;Arg mutant of the C-terminal K-homology (KH) domain of hnRNP K by NMR spectroscopy.	Arginine	60-63	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	115-122
12631327-2	2003	The arg11 mutant requires arginine (Arg) supplementation because it fails to export sufficient ornithine from the mitochondrion to the cytosol where it is converted to arginine.	Arginine	168-176	Ort1p	Saccharomyces cerevisiae S288C	4-9
10410240-8	1999	Preincubation of the inhibitor with a number of amino acids showed that only arginine and its derivative N alpha-Benzoyl-L-Arginine ethyl ester interact with the inhibitor, noticeably reducing its ability to inhibit porphyrinogen carboxy-lyase.	Arginine	77-85	uroporphyrinogen decarboxylase	Rattus norvegicus	216-243
12411439-3	2003	The alleles differ at only one amino acid position, where an arginine at position 107 in HLA-E*0101 (E(R)) is replaced by a glycine in HLA-E*0103 (E(G)).	Arginine	61-69	major histocompatibility complex, class I, E	Homo sapiens	89-94
10330133-7	1999	On the other hand, a 49-amino-acid segment, rich in lysines and arginines and located immediately downstream of the p105(Rb) interaction domain, appeared to be essential in this assay.	Arginine	64-73	RB transcriptional corepressor 1	Homo sapiens	116-124
10336872-5	1999	E. coli BL21(DE3) cotransformed with the CKS1At gene and the E. coli argU gene that encoded the arginine acceptor tRNAUCU produced a sufficient amount of p10CKS1At to start the structural study by NMR.	Arginine	96-104	cyclin-dependent kinase-subunit 1	Arabidopsis thaliana	154-163
10336872-6	1999	Replacement of four rare codons in the CKS1At gene sequence, including a tandem arginine, by highly used codons in E. coli, restored also a high expression of the recombinant protein.	Arginine	80-88	cyclin-dependent kinase-subunit 1	Arabidopsis thaliana	39-45
12454018-6	2003	The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac1 and RhoA in vitro and in vivo, and the conserved catalytic arginine residue (Arg-58) contributed to the GAP activity.	Arginine	132-140	Rho GTPase activating protein 32	Mus musculus	21-31
10336496-5	1999	Two separate domains of nucleolin can interact with G-G-paired DNA, the four RNA binding domains and the C-terminal Arg-Gly-Gly repeats.	Arginine	116-119	nucleolin	Homo sapiens	24-33
12454018-6	2003	The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac1 and RhoA in vitro and in vivo, and the conserved catalytic arginine residue (Arg-58) contributed to the GAP activity.	Arginine	132-140	Rho GTPase activating protein 32	Mus musculus	7-10
10335982-3	1999	Hb St. Luke"s [alpha95(G2)Pro--&gt;Arg] was found to result from a C--&gt;G mutation at the second position of codon 95 on an alpha1-globin gene, and Hb Setif [alpha94(G1) Asp--&gt;Tyr] resulted from a G--&gt;T mutation at the first position of codon 94 on an alpha2-globin gene.	Arginine	35-38	hemoglobin subunit alpha 2	Homo sapiens	260-273
12454018-6	2003	The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac1 and RhoA in vitro and in vivo, and the conserved catalytic arginine residue (Arg-58) contributed to the GAP activity.	Arginine	150-153	Rho GTPase activating protein 32	Mus musculus	21-31
12454018-6	2003	The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac1 and RhoA in vitro and in vivo, and the conserved catalytic arginine residue (Arg-58) contributed to the GAP activity.	Arginine	150-153	ras homolog family member A	Mus musculus	77-81
10217293-6	1999	The site of cleavage, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry, is N-terminal to the Arg at the P1 position for the dynorphin converting enzyme and C-terminal to the Arg at the P1 position for furin and prohormone convertase 1.	Arginine	138-141	furin, paired basic amino acid cleaving enzyme	Homo sapiens	246-251
12454018-6	2003	The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac1 and RhoA in vitro and in vivo, and the conserved catalytic arginine residue (Arg-58) contributed to the GAP activity.	Arginine	150-153	Rho GTPase activating protein 32	Mus musculus	7-10
10217293-6	1999	The site of cleavage, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry, is N-terminal to the Arg at the P1 position for the dynorphin converting enzyme and C-terminal to the Arg at the P1 position for furin and prohormone convertase 1.	Arginine	219-222	furin, paired basic amino acid cleaving enzyme	Homo sapiens	246-251
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Arginine	122-132	arginase, liver	Mus musculus	45-55
10199792-13	1999	Our results suggest that missense mutations that replace cysteine with either arginine or serine cause an abnormal three-dimensional structure of Tg.	Arginine	78-86	thyroglobulin	Homo sapiens	146-148
12604233-5	2003	Recently, we reported that the solubility of 11beta-HSD 1 could be increased by substitution of hydrophobic amino acid residues with arginine without affecting activity.	Arginine	133-141	diacylglycerol kinase	Saccharomyces cerevisiae S288C	45-57
10194517-2	1999	Occupation of these receptors, via Arg-Gly-Asp (RGD) recognition sequences, leads to activation of focal adhesion kinase (FAK).	Arginine	35-38	protein tyrosine kinase 2	Homo sapiens	99-120
10194517-2	1999	Occupation of these receptors, via Arg-Gly-Asp (RGD) recognition sequences, leads to activation of focal adhesion kinase (FAK).	Arginine	35-38	protein tyrosine kinase 2	Homo sapiens	122-125
10213479-10	1999	We speculate that, as observed for STOP protein, the increase in the degradation of protein that occurs in hyperthermia, would produce an increase in the amount of arginine acceptor proteins.	Arginine	164-172	microtubule-associated protein 6	Rattus norvegicus	35-39
10090723-4	1999	The asymmetry in the extended binding site TTTc/gGCGCc/g is associated with an amino-terminal extension of E2F4, in which an arginine binds in the minor groove near the TTT stretch.	Arginine	125-133	E2F transcription factor 4	Homo sapiens	107-111
10051408-1	1999	Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion.	Arginine	30-33	transcription elongation factor A like 1	Homo sapiens	6-9
10051408-1	1999	Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion.	Arginine	30-33	transcription elongation factor A like 1	Homo sapiens	10-14
10022858-6	1999	Analysis of selected splicing enhancer elements and other enhancers in S100 complementation assays led to the identification of individual enhancers capable of being activated by specific serine/arginine (SR)-rich splicing factors (SC35, 9G8, and SF2/ASF).	Arginine	195-203	Splicing factor 2	Drosophila melanogaster	247-250
10022858-6	1999	Analysis of selected splicing enhancer elements and other enhancers in S100 complementation assays led to the identification of individual enhancers capable of being activated by specific serine/arginine (SR)-rich splicing factors (SC35, 9G8, and SF2/ASF).	Arginine	195-203	Splicing factor 2	Drosophila melanogaster	251-254
10433375-5	1999	L-arg (2 mM) has significantly decreased the lead-induced NAG release (P &lt; 0.001), and L-NAME (0.1 mM) has significantly increased the lead-induced enzyme release in a time-dependent manner (P &lt; 0.001).	Arginine	0-5	O-GlcNAcase	Rattus norvegicus	58-61
10050771-3	1999	We sought to characterise the surface topology of the quaternary structure-dependent heparin-binding region of PDC-109 by comparing the arginine- and lysine-selective chemical modification patterns of the free and the heparin-bound protein.	Arginine	136-144	seminal plasma protein PDC-109	Bos taurus	111-118
10069453-4	1999	For cdk4/D1, the preferred amino acid at the third position C-terminal to the phosphorylated serine/threonine is arginine.	Arginine	113-121	cyclin dependent kinase 4	Homo sapiens	4-8
10051761-6	1999	The arginine stems from post-transcriptional editing of the GluR5 and GluR6 pre-RNAs, and the unedited and edited versions of GluR6 elicit distinct Ca2+ permeability.	Arginine	4-12	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	70-75
9891055-3	1999	Here, we report that the arginine-rich NLS sequences present in the human immunodeficiency virus type 1 regulatory proteins Tat and Rev fail to interact with Imp alpha and instead bind directly to Imp beta.	Arginine	25-33	tyrosine aminotransferase	Homo sapiens	124-127
9891055-3	1999	Here, we report that the arginine-rich NLS sequences present in the human immunodeficiency virus type 1 regulatory proteins Tat and Rev fail to interact with Imp alpha and instead bind directly to Imp beta.	Arginine	25-33	Rev	Human immunodeficiency virus 1	132-135
10027703-2	1999	In vitro, MBP-associated arginine is deiminated to citrulline by the enzyme peptidylarginine deiminase (PAD).	Arginine	25-33	myelin basic protein	Homo sapiens	10-13
9874795-6	1999	These results are consistent with a model that places arginine at position five of Ac1-11 in pockets 4 and 7 of the MHC groove, which is formed in part by residues 26, 28, 70, and 74 of Abetau and places lysine at position four of Ac1-11, previously shown to be a major MHC contact, in hydrophobic pocket 6.	Arginine	54-62	adenylate cyclase 1	Mus musculus	83-86
9874795-6	1999	These results are consistent with a model that places arginine at position five of Ac1-11 in pockets 4 and 7 of the MHC groove, which is formed in part by residues 26, 28, 70, and 74 of Abetau and places lysine at position four of Ac1-11, previously shown to be a major MHC contact, in hydrophobic pocket 6.	Arginine	54-62	adenylate cyclase 1	Mus musculus	231-234
10078337-0	1999	Structural organization of the human eukaryotic initiation factor 5A precursor and its site-directed variant Lys50--&gt;Arg.	Arginine	120-123	eukaryotic translation initiation factor 5A2	Homo sapiens	37-68
27389509-7	1999	The best substrate for cathepsin D was Arg-Pro-Lys-Pro-Leu-Leu-Phe(NO2)-Tyr-Leu-Leu and its kcat/Km was 1.3 muM(-1) s(-1).	Arginine	39-42	cathepsin D	Homo sapiens	23-34
10051125-7	1999	Pretreatment with L-NAME (5 mg kg(-1)) did not change basal PIP, but increased, in L-arginine sensitive manner, the magnitude of the PIP increases (in both amplitude and duration) triggered by each of the peptides (at 0.25, 0.4 and 1.0 nmol kg(-1), respectively), without modifying bronchoconstriction caused by U 46619 (0.57 nmol kg(-1)).	Arginine	83-93	prolactin-inducible protein homolog	Cavia porcellus	133-136
9916128-2	1999	L-arginine (L-ARG) given intravenously or interstitially enhanced net fluid absorption and cGMP formation, which were completely blocked by the nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine methylester (L-NAME), but not by the specific AT2 receptor antagonist, PD-123319 (PD).	Arginine	0-10	angiotensin II receptor, type 2	Rattus norvegicus	247-250
9916128-2	1999	L-arginine (L-ARG) given intravenously or interstitially enhanced net fluid absorption and cGMP formation, which were completely blocked by the nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine methylester (L-NAME), but not by the specific AT2 receptor antagonist, PD-123319 (PD).	Arginine	12-17	angiotensin II receptor, type 2	Rattus norvegicus	247-250
10201644-1	1999	The involvement of the L-arginine/NO pathway in the control of salivary fluid, amylase and epidermal growth factor (EGF) secretion was investigated in conscious rats.	Arginine	23-33	epidermal growth factor like 1	Rattus norvegicus	91-114
9857030-9	1998	One such residue, Ala-72 (Arg in ubiquitin), is shown to perform a key role in selecting against reaction with the ubiquitin E1 enzyme, thereby acting to prevent the inappropriate diversion of NEDD8 into ubiquitin-specific pathways.	Arginine	26-29	NEDD8 ubiquitin like modifier	Homo sapiens	193-198
9832162-6	1998	The distribution of amine donors correlated closely with that of Arg residues, suggesting a link between neighboring positive charge and the TGase selectivity for donor sites in the protein substrate.	Arginine	65-68	transglutaminase 1	Homo sapiens	141-146
9846874-4	1998	The Cdc42GAP stabilizes both the switch I and switch II domains of Cdc42 and contributes a highly conserved arginine (Arg 305) to the active site.	Arginine	108-116	cell division cycle 42	Homo sapiens	4-9
9846874-4	1998	The Cdc42GAP stabilizes both the switch I and switch II domains of Cdc42 and contributes a highly conserved arginine (Arg 305) to the active site.	Arginine	118-121	cell division cycle 42	Homo sapiens	4-9
9799598-9	1998	The predicted mouse GPR37 protein contains seven putative hydrophobic transmembrane domains, as well as a long (249 amino acid residues), arginine- and proline-rich amino-terminal extracellular domain, which is also a distinctive feature of the human GPR37 receptor.	Arginine	138-146	G protein-coupled receptor 37	Mus musculus	20-25
12560466-6	2003	RESULTS: A glutamine to arginine mutation was detected in exon 5 of the p73 gene in a case of adenocarcinoma at the gastro-oesophageal junction.	Arginine	24-32	tumor protein p73	Homo sapiens	72-75
9786934-3	1998	hnRNP D and nucleolin both contain canonical RNA binding domains (RBDs also called RRMs) and Arg-Gly-Gly (RGG) motifs.	Arginine	93-96	nucleolin	Homo sapiens	12-21
9790687-2	1998	BNP was tentatively identified as a heparin-binding protein on the basis of its cyclic structure and the high frequency of the basic amino acid residues, lysine and arginine.	Arginine	165-173	natriuretic peptide B	Homo sapiens	0-3
12589064-8	2003	Rat ykt6, which contains an arginine in its SNARE motif zero-layer, was found to behave like other R-SNAREs in its SNARE assembly properties.	Arginine	28-36	YKT6 v-SNARE homolog	Rattus norvegicus	4-8
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Arginine	175-178	ectodysplasin A	Homo sapiens	48-51
9756941-3	1998	Using a new approach to monitor GDI-Rab interactions based on the change in fluorescence associated with the release of methylanthraniloyl guanosine di(tri)phosphate-GDP (mGDP) from Rab, we show that residues previously implicated in the binding of the synapse-specific Rab3A, including Gln-236, Arg-240, and Thr-248, are essential for the binding of Rab1A.	Arginine	296-299	RAB1A, member RAS oncogene family	Homo sapiens	36-39
9756941-7	1998	Intriguingly, mutation of one residue, Arg-70, led to a reduction of Rab1A binding, failed to extract Rab1A from membranes in vitro, yet bound membranes tightly and potently inhibited ER to Golgi transport.	Arginine	39-42	RAB1A, member RAS oncogene family	Homo sapiens	69-74
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Arginine	175-178	ectodysplasin A	Homo sapiens	137-140
12568929-6	2003	We also determined the recognition structure of EDA(+)FN for Hep by an inhibition experiment on the heparin binding domain II (HepII) in EDA(+)FN with the synthetic peptides, Arg-Arg-Ala-Arg (RRAR), Asp-Gln-Ala-Arg (DNAR), Ile-Lys-Tyr-Glu-Lys (IKYEK), and Gly-Arg-Lys-Lys-Try (GRKKT).	Arginine	179-182	ectodysplasin A	Homo sapiens	48-51
12507903-4	2003	Here we show that arginase 1 (ARG1), which substantially participates in the regulation of iNOS activity by competing for the common substrate L-arginine, is highly overexpressed in the hyperproliferative psoriatic epidermis and is co-expressed with iNOS.	Arginine	143-153	arginase 1	Homo sapiens	18-28
9745037-1	1998	Mammals contain two genes encoding distinct isoforms of arginase (arginases I and II), both of which catalyze the conversion of arginine to ornithine and urea.	Arginine	128-136	arginase, liver	Mus musculus	35-84
12507903-4	2003	Here we show that arginase 1 (ARG1), which substantially participates in the regulation of iNOS activity by competing for the common substrate L-arginine, is highly overexpressed in the hyperproliferative psoriatic epidermis and is co-expressed with iNOS.	Arginine	143-153	arginase 1	Homo sapiens	30-34
14509925-2	2003	Modulations of the activities of neuronal NO-synthase (nNOS) in the populations of the cardiovascular neurons within the medullary nuclei which are involved in the reflector cardiovascular control were induced by intramedullary injections of sodium nitroprusside as NO donor, L-arginine as NO precursor, L-NNA as an inhibitor of NOS, as well as by intraperetoneal injections of 7-nitroindazol (nNOS inhibitor).	Arginine	276-286	nitric oxide synthase 1	Homo sapiens	33-53
9753439-8	1998	Both the mono- and pentaglutamate derivatives of 5-CHO-H4PteGlun were cross-linked to SHMT by a carbodiimide reaction to Lys-450 which resides in a stretch of Lys, His, and Arg residues.	Arginine	173-176	serine hydroxymethyltransferase, cytosolic	Oryctolagus cuniculus	86-90
14509925-2	2003	Modulations of the activities of neuronal NO-synthase (nNOS) in the populations of the cardiovascular neurons within the medullary nuclei which are involved in the reflector cardiovascular control were induced by intramedullary injections of sodium nitroprusside as NO donor, L-arginine as NO precursor, L-NNA as an inhibitor of NOS, as well as by intraperetoneal injections of 7-nitroindazol (nNOS inhibitor).	Arginine	276-286	nitric oxide synthase 1	Homo sapiens	55-59
12455060-2	2003	It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G--&gt;A transition at codon 213, carries a significantly higher risk for women to develop breast cancer.	Arginine	92-95	sulfotransferase family 1A member 1	Homo sapiens	31-38
9733991-10	1998	When direct uptake measurements were carried out, both lysine and arginine were found to be effective substrates for RcAAP1.	Arginine	66-74	amino acid permease 3	Ricinus communis	117-123
9760183-6	1998	Arginine residue mutations in Chs3p, and in Chs1p and Chs2p, resulted in a loss of both function in vivo and enzymatic activity.	Arginine	0-8	chitin synthase CHS1	Saccharomyces cerevisiae S288C	44-49
9715804-1	1998	The effect of acute treatment with L-arginine, a substrate for nitric oxide synthase (NOS) that forms NO, an important second messenger, on morphine antinociception and distribution of morphine in central and peripheral tissues of male Swiss-Webster mice was determined.	Arginine	35-45	nitric oxide synthase 1, neuronal	Mus musculus	63-84
9742507-2	1998	The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investigated using NB9 human neuroblastoma cells (NB9), which express neuronal nitric oxide synthase (nNOS).	Arginine	48-58	nitric oxide synthase 1	Homo sapiens	141-171
9742507-2	1998	The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investigated using NB9 human neuroblastoma cells (NB9), which express neuronal nitric oxide synthase (nNOS).	Arginine	48-58	nitric oxide synthase 1	Homo sapiens	173-177
9742507-2	1998	The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investigated using NB9 human neuroblastoma cells (NB9), which express neuronal nitric oxide synthase (nNOS).	Arginine	60-65	nitric oxide synthase 1	Homo sapiens	141-171
9742507-2	1998	The cytotoxic effect of a high concentration of L-arginine (L-Arg) was investigated using NB9 human neuroblastoma cells (NB9), which express neuronal nitric oxide synthase (nNOS).	Arginine	60-65	nitric oxide synthase 1	Homo sapiens	173-177
9742507-9	1998	The apparent Km value of nNOS for L-Arg was 8.4 microM, with a Vmax value of 8.2 pmol/min/mg protein.	Arginine	34-39	nitric oxide synthase 1	Homo sapiens	25-29
9742507-11	1998	These results suggest that L-Cit formed by nNOS in L-Arg-loaded neuronal cells inhibits NOS activity and nNOS in these L-Arg-loaded cells functions as a NADPH oxidase to produce ROS, which may cause neurotoxicity in argininemia.	Arginine	51-56	nitric oxide synthase 1	Homo sapiens	43-47
9742507-11	1998	These results suggest that L-Cit formed by nNOS in L-Arg-loaded neuronal cells inhibits NOS activity and nNOS in these L-Arg-loaded cells functions as a NADPH oxidase to produce ROS, which may cause neurotoxicity in argininemia.	Arginine	51-56	nitric oxide synthase 1	Homo sapiens	105-109
9742507-11	1998	These results suggest that L-Cit formed by nNOS in L-Arg-loaded neuronal cells inhibits NOS activity and nNOS in these L-Arg-loaded cells functions as a NADPH oxidase to produce ROS, which may cause neurotoxicity in argininemia.	Arginine	119-124	nitric oxide synthase 1	Homo sapiens	43-47
9742507-11	1998	These results suggest that L-Cit formed by nNOS in L-Arg-loaded neuronal cells inhibits NOS activity and nNOS in these L-Arg-loaded cells functions as a NADPH oxidase to produce ROS, which may cause neurotoxicity in argininemia.	Arginine	119-124	nitric oxide synthase 1	Homo sapiens	105-109
9683508-3	1998	NOS-independent conversion of radiolabeled L-arginine to L-citrulline occurs due to arginase- and ornithine transcarbamylase-mediated reactions and this limits the accuracy of this assay for measurement of NOS activity.	Arginine	43-53	ornithine transcarbamylase	Rattus norvegicus	98-124
9688579-6	1998	The IC50 for nNOS was 18 +/- 6 microM GST-PIN with 63 nM nNOS after 30 min at 37 degrees C. Uncoupled NADPH oxidation was inhibited similarly, whereas cytochrome c reductase activity, the K(M) for L-arginine, and dimerization were unaffected.	Arginine	197-207	nitric oxide synthase 1	Homo sapiens	13-17
9642058-12	1998	The mutant protein, in the absence of L-citrulline or L-arginine is as strong a repressor as the wild-type protein in the presence of L-arginine.	Arginine	54-64	repressor	Escherichia coli	80-89
9642058-12	1998	The mutant protein, in the absence of L-citrulline or L-arginine is as strong a repressor as the wild-type protein in the presence of L-arginine.	Arginine	134-144	repressor	Escherichia coli	80-89
9614060-4	1998	High affinity L-arginine transport was investigated in embryonic fibroblast cells derived from Cat1 knockout mice that lack functional Cat1.	Arginine	14-24	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	95-99
9614060-10	1998	These results suggest that Cat3 compensates for the loss of functional Cat1 in cells derived from Cat1 knockout mice and mediates the majority of high affinity arginine transport.	Arginine	160-168	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	71-75
9614060-10	1998	These results suggest that Cat3 compensates for the loss of functional Cat1 in cells derived from Cat1 knockout mice and mediates the majority of high affinity arginine transport.	Arginine	160-168	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	98-102
9576954-4	1998	Site-directed mutagenesis carried out on three such V3 residues revealed that the Arg-298 of HIV-1 gp120 has an important role in CCR5 utilization.	Arginine	82-85	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	99-104
9572854-0	1998	Arginine 719 in human plasminogen mediates formation of the staphylokinase:plasmin activator complex.	Arginine	0-8	plasminogen	Homo sapiens	22-29
9614933-4	1998	A coding sequence polymorphism of CR1 predicted to cause a Pro--&gt;Arg substitution in its proximal extramembranous region was tightly linked in Caucasians to the site of the HindIII RFLP.	Arginine	68-71	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	34-37
9614933-6	1998	Relative instability of CR1 encoded by the L allele thus may derive from another coding sequence polymorphism, or may require both the Pro--&gt;Arg substitution and epistatic effects of another polymorphic gene.	Arginine	144-147	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	24-27
12455060-2	2003	It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G--&gt;A transition at codon 213, carries a significantly higher risk for women to develop breast cancer.	Arginine	97-105	sulfotransferase family 1A member 1	Homo sapiens	31-38
12455060-3	2003	We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan.	Arginine	52-55	sulfotransferase family 1A member 1	Homo sapiens	44-51
12496409-7	2003	Because Arg1 and iNOS share L-arginine as a common substrate, our results indicate that L-arginine metabolism in myeloid cells is a potential target for selective intervention in reversing myeloid-induced dysfunction in tumor-bearing hosts.	Arginine	88-98	arginase, liver	Mus musculus	8-12
14626446-1	2003	The multi-functional protein gC1qR has been reported to interact with an arginine-rich motif in the C-tail of hamster alpha1B-adrenoceptors (ARs), controlling their expression and subcellular localization.	Arginine	73-81	complement C1q binding protein	Homo sapiens	29-34
14626446-5	2003	C-terminal truncation of Flag-alpha1-ARs prevented interaction with HA-gC1qR, supporting previous conclusions about the role of the C-terminal arginine-rich motif.	Arginine	143-151	complement C1q binding protein	Homo sapiens	71-76
12759556-1	2003	Nitric oxide (NO) is produced from its precursor L-arginine by the enzyme NO synthase (NOS), which includes at least three distinct isoforms - neuronal (nNOS), endothelial, and inducible NOS.	Arginine	49-59	nitric oxide synthase 1	Homo sapiens	74-85
12759556-1	2003	Nitric oxide (NO) is produced from its precursor L-arginine by the enzyme NO synthase (NOS), which includes at least three distinct isoforms - neuronal (nNOS), endothelial, and inducible NOS.	Arginine	49-59	nitric oxide synthase 1	Homo sapiens	153-157
12486110-7	2002	Our findings support a model in which arginine methylation is important for the localization of coilin and SMN in Cajal bodies.	Arginine	38-46	coilin	Homo sapiens	96-102
12486110-7	2002	Our findings support a model in which arginine methylation is important for the localization of coilin and SMN in Cajal bodies.	Arginine	38-46	survival of motor neuron 1, telomeric	Homo sapiens	107-110
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Arginine	188-196	E1A binding protein p300	Homo sapiens	8-12
12429500-7	2002	With an aspartic acid at position 58 in 17beta-HSD-3 occupying the equivalent space in the cofactor binding pocket as arginine 224 in glutathione reductase or serine 12 in 17beta-HSD-1, there was an expectation that some of the mutants might use NADH as a cofactor.	Arginine	118-126	glutathione-disulfide reductase	Homo sapiens	134-155
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Arginine	121-124	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
12417259-5	2002	When a MARCKS (myristoylated alanine-rich C-kinase substrate)-derived peptide substrate (Gly-Ala-Gln-Phe-Ser-Lys-Thr-Ala-Arg-Arg) and the M2 gene segment of the reovirus type 3 peptide substrate (Gly-Asn-Ala-Ser-Ser-Ile-Lys-Lys-Lys) were used, hNMT activity was increased by approximately 8.5- and 7-fold, respectively.	Arginine	125-128	myristoylated alanine rich protein kinase C substrate	Homo sapiens	7-13
12228246-3	2002	By the stepwise deletion of VR1 and by chimera construction using its capsaicin-insensitive homologue, VRL1, we localized key amino acids, Arg-114 and Glu-761, in the N- and C-cytosolic tails, respectively, that determine ligand binding.	Arginine	139-142	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-31
12228246-3	2002	By the stepwise deletion of VR1 and by chimera construction using its capsaicin-insensitive homologue, VRL1, we localized key amino acids, Arg-114 and Glu-761, in the N- and C-cytosolic tails, respectively, that determine ligand binding.	Arginine	139-142	transient receptor potential cation channel subfamily V member 2	Homo sapiens	103-107
12390319-6	2002	In contrast, PE phagocytosis with Fc(gamma)RIIa-Arg/Arg131 tended to be higher with an IgG1-containing pool.	Arginine	48-51	Fc gamma receptor IIa	Homo sapiens	34-47
12379365-4	2002	The identified cleavage sites are evenly spread throughout the FVIII molecule and are located after an arginine or a lysine in most cases.	Arginine	103-111	coagulation factor VIII	Homo sapiens	63-68
12513909-7	2002	Three-dimensional models of IL-22 and IL-10 receptor complexes suggest two receptor residues (Gly-44 and Arg-96) are largely responsible for the marked differences in ligand affinity observed for sIL-10R1 and sIL-22R vs. sIL-10R2.	Arginine	105-108	STIL centriolar assembly protein	Homo sapiens	196-199
12513909-7	2002	Three-dimensional models of IL-22 and IL-10 receptor complexes suggest two receptor residues (Gly-44 and Arg-96) are largely responsible for the marked differences in ligand affinity observed for sIL-10R1 and sIL-22R vs. sIL-10R2.	Arginine	105-108	STIL centriolar assembly protein	Homo sapiens	209-212
12513909-7	2002	Three-dimensional models of IL-22 and IL-10 receptor complexes suggest two receptor residues (Gly-44 and Arg-96) are largely responsible for the marked differences in ligand affinity observed for sIL-10R1 and sIL-22R vs. sIL-10R2.	Arginine	105-108	STIL centriolar assembly protein	Homo sapiens	209-212
12698555-3	2002	In 1998 we found an unusual calcium-dependent autolysis of the enteropeptidase heavy chain leading to the drastic loss of its activity towards trypsinogen: after lysine-360 (-NNYEK360-INCN-), -), arginine-384 (-NEWER384-TQGS-), arginine-422 (-GRRER422-VGLL-) and lysine-465 (-QNMEK465-TIFQ-) residues.	Arginine	196-204	transmembrane serine protease 15	Homo sapiens	63-78
12698555-3	2002	In 1998 we found an unusual calcium-dependent autolysis of the enteropeptidase heavy chain leading to the drastic loss of its activity towards trypsinogen: after lysine-360 (-NNYEK360-INCN-), -), arginine-384 (-NEWER384-TQGS-), arginine-422 (-GRRER422-VGLL-) and lysine-465 (-QNMEK465-TIFQ-) residues.	Arginine	228-236	transmembrane serine protease 15	Homo sapiens	63-78
9521906-9	1998	Transgenes expressing a mutant tiggrin, whose Arg-Gly-Asp (RGD) integrin recognition sequence has been mutated to Leu-Gly-Ala (LGA) show much reduced, but significant, rescuing ability.	Arginine	46-49	Tiggrin	Drosophila melanogaster	31-38
12487923-5	2002	RESULTS: (1) According to FGR group, L-arg group, CHM group and normal group, the expression of ERK-1 in brain was 7.63 +/- 0.22, 10.03 +/- 0.41, 11.03 +/- 0.30, 11.44 +/- 0.09 and MKP-1 was 7.41 +/- 0.38, 10.35 +/- 0.60, 10.60 +/- 0.14, 11.60 +/- 0.62.	Arginine	37-42	mitogen activated protein kinase 3	Rattus norvegicus	96-101
12361482-12	2002	CONCLUSIONS: The human L-threonine 3-dehydrogenase gene is an expressed pseudogene having lost the splice acceptor site preceding exon 6 and codon arginine-214 (CGA) is mutated to a stop codon (TGA).	Arginine	147-155	T-box transcription factor 1	Homo sapiens	194-197
12351453-7	2002	Treatment with L-NAME increased, whereas treatment with L-arginine or nitroglycerine patches decreased AR activity and sorbitol content in tissues of diabetic rats.	Arginine	56-66	aldo-keto reductase family 1 member B1	Rattus norvegicus	103-105
9564049-3	1998	In the presence of ATP, hMutSalpha dissociated from mismatched oligonucleotide substrates, and this reaction was attenuated by mutating the conserved lysine in the ATP-binding domains of hMSH6, hMSH2 or both to arginine.	Arginine	211-219	mutS homolog 2	Homo sapiens	194-199
9564049-5	1998	The ATPase activity of hMutSalpha variants carrying the Lys--&gt;Arg mutation in hMSH2 or in hMSH6 was severely affected, but these mutants were still proficient in mismatch binding and were able to complement, albeit to different extents, mismatch repair-deficient cell extracts.	Arginine	65-68	dynein axonemal heavy chain 8	Homo sapiens	4-10
12220888-7	2002	However, similar to anti-DNA antibodies, pathogenic antiphospholipid antibodies contain an increased number of arginine residues in the third complimentarity-determining region (CDR3) of their H chains.	Arginine	111-119	CDR3	Homo sapiens	178-182
9564049-5	1998	The ATPase activity of hMutSalpha variants carrying the Lys--&gt;Arg mutation in hMSH2 or in hMSH6 was severely affected, but these mutants were still proficient in mismatch binding and were able to complement, albeit to different extents, mismatch repair-deficient cell extracts.	Arginine	65-68	mutS homolog 2	Homo sapiens	81-86
9667070-2	1998	Besides, we estimated the density of renal AT1 receptors using the quantification of macro-ARG.	Arginine	91-94	angiotensin II receptor, type 1a	Rattus norvegicus	43-46
9667070-5	1998	Macro-ARG revealed that the amount of both Ang II and AT1 receptors in the renal medulla greatly exceeded those in the renal cortex.	Arginine	6-9	angiotensin II receptor, type 1a	Rattus norvegicus	54-57
9667070-9	1998	The present study established a method for ARG of AT1 receptors in the kidney as well as a method for quantifying the macro-ARG.	Arginine	43-46	angiotensin II receptor, type 1a	Rattus norvegicus	50-53
12220888-8	2002	The increased accumulation of arginine residues in the V(H) CDR3 may act to enhance antigen binding, promote disease and point to the importance of the H chain in the pathogenic potential of certain antiphospholipid antibodies.	Arginine	30-38	CDR3	Homo sapiens	60-64
12171910-0	2002	Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.	Arginine	0-8	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	65-100
9553103-1	1998	The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor.	Arginine	14-22	gonadotropin releasing hormone receptor	Homo sapiens	41-80
9553103-3	1998	Mutation of this Arg in the gonadotropin-releasing hormone receptor to Gln, His, or Lys abolished or severely impaired agonist-stimulated inositol phosphate generation, consistent with Arg having a role in receptor activation.	Arginine	17-20	gonadotropin releasing hormone receptor	Homo sapiens	28-67
9553103-3	1998	Mutation of this Arg in the gonadotropin-releasing hormone receptor to Gln, His, or Lys abolished or severely impaired agonist-stimulated inositol phosphate generation, consistent with Arg having a role in receptor activation.	Arginine	185-188	gonadotropin releasing hormone receptor	Homo sapiens	28-67
12171910-2	2002	Here we show that arginine methylation of STAT1 controls the rate of STAT1 dephosphorylation by modulating its interaction with PIAS1 and the nuclear tyrosine phosphatase TcPTP.	Arginine	18-26	protein tyrosine phosphatase non-receptor type 2	Homo sapiens	171-176
12070147-4	2002	When the lysine residue at the putative ubiquitination site of the N-degron was substituted with arginine, both the protein level and half-life of mutant Gts1p increased.	Arginine	97-105	Gts1p	Saccharomyces cerevisiae S288C	154-159
9719479-3	1998	In HT-29 Glc-/+ cells, L-arginine is the major precursor of these molecules through the sequential actions of arginase, which leads to L-ornithine generation and ODC.	Arginine	23-33	ornithine decarboxylase 1	Homo sapiens	162-165
9719479-11	1998	The inhibitory effect of DFMO upon arginase, one step upstream of the ODC reaction in the metabolic conversion of L-arginine to polyamines, is of potential physiological importance, since it could alter the production of ornithine and thus its metabolism in pathways other than the ODC pathway.	Arginine	114-124	ornithine decarboxylase 1	Homo sapiens	70-73
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	54-57	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	54-57	parathyroid hormone like hormone	Homo sapiens	214-219
9535830-6	1998	The human pro-PTH processing site Lys-Ser-Val-Lys-Lys-Arg differs from the consensus furin site Arg-Xaa-(Lys/Arg)-Arg that is represented by Arg-Arg-Leu-Lys-Arg in the cleavage site of pro-PTH-related peptide (pro-PTHrP).	Arginine	96-99	furin, paired basic amino acid cleaving enzyme	Homo sapiens	85-90
12119305-3	2002	The PDZKI-interacting domain on SR-BI was identified as the last three carboxyl-terminal amino acids, Arg-Lys-Leu.	Arginine	102-105	scavenger receptor class B, member 1	Mus musculus	32-37
9584989-3	1998	Sodium dodecyl sulphate polyacrylamide gel-electrophoresis and microsequence analysis showed that the glyoxalase II is proteolyzed at the level of Arg 184 and Lys 230 and undergoes a third cleavage in a region located at the beginning of the supposed C-terminal domain.	Arginine	147-150	hydroxyacylglutathione hydrolase	Homo sapiens	102-115
12213838-5	2002	Our data indicate that it is specifically the 4.1 protein/ezrin/radixin/moesin (FERM) domain binding consensus, and in particular, an arginine at position 7 in the cytoplasmic tail of Crumbs that is essential to efficiently recruit both the apical SBMS and the FERM domain protein, DMoesin.	Arginine	134-142	Moesin	Drosophila melanogaster	282-289
9578464-0	1998	Bilitranslocase can exist in two metastable forms with different affinities for the substrates--evidence from cysteine and arginine modification.	Arginine	123-131	ceruloplasmin	Rattus norvegicus	0-15
9521765-1	1998	Binding of azide to the native and arginine-modified bovine Cu,Zn superoxide dismutase in the oxidized and reduced form and to the copper-free derivative has been investigated by Fourier transform infrared spectroscopy.	Arginine	35-43	superoxide dismutase [Cu-Zn]	Bos taurus	60-86
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Arginine	33-36	mucin 1, cell surface associated	Homo sapiens	154-158
9562267-1	1998	Nitric oxide, a potent signalling molecule produced from L-arginine by nitric oxide synthase (NOS), has been implicated in diverse pathophysiological processes.	Arginine	57-67	nitric oxide synthase 1	Homo sapiens	71-92
9498770-3	1998	Further examination of the three-dimensional structure in this region revealed conformational differences between human and murine beta2m that affect the ability of an aspartic acid residue at position 53 (D53) conserved in both beta 2ms to form an ionic bond with arginine residues at positions 35 and 48 of the heavy chain.	Arginine	265-273	beta-2 microglobulin	Mus musculus	131-137
12165038-3	2002	The arylsulphotransferase SULT1A1 has been implicated in a decreased activity and thermostability when the wild-type arginine at position 213 of the coding sequence is substituted by a histidine.	Arginine	117-125	sulfotransferase family 1A member 1	Homo sapiens	26-33
12884975-7	2002	One polymorphism, causing the Trp7Arg change in the putative signal peptide, showed a trend towards excess of the arginine encoding allele in a case-control sample consisting of 520 DSM-IV schizophrenia patients and 535 matched controls from the UK (chi2=3.72, P [1 df]= 0.054).	Arginine	114-122	transient receptor potential cation channel subfamily C member 7	Homo sapiens	30-34
9452427-3	1998	At the -3 position, substitution of Ala for Arg leads to decreases of 99- and 343- fold in Vmax/Km for CaMKIV and CaMKIIalpha, respectively.	Arginine	44-47	calcium/calmodulin dependent protein kinase IV	Homo sapiens	103-109
9452427-6	1998	Substitution of Arg at the -2 position with non-basic residues (Gln or Ala) leads to 6-fold decreases in Vmax/Km for CaMKIV, but 17-28-fold increases for CaMKIIalpha.	Arginine	16-19	calcium/calmodulin dependent protein kinase IV	Homo sapiens	117-123
11967263-11	2002	In conclusion, we have found that the Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and that targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45).	Arginine	38-41	glycogen synthase kinase 3 beta	Homo sapiens	87-96
9452427-8	1998	Thus, CaMKIV and CaMKIIalpha preferentially phosphorylate substrates with the motifs: Hyd-X-Arg-X-X-Ser*/Thr*, and Hyd-X-Arg-NB-X-Ser*/Thr*-Hyd, respectively, where Hyd represents a hydrophobic, X any, and NB a non-basic amino acid residue.	Arginine	92-95	calcium/calmodulin dependent protein kinase IV	Homo sapiens	6-12
9495519-8	1998	This single base substitution changes the codon for arginine (CGA) to an opal stop codon (TGA), resulting in the truncation of the VDR at amino acid 30.	Arginine	52-60	T-box transcription factor 1	Homo sapiens	90-93
9473451-4	1998	After rapid dilution of washed, guanidine hydrochloride-denatured inclusion bodies into a glutathione-, l-arginine-containing renaturation buffer, an active carbonic anhydrase IV at yields of 3-4 mg/liter was easily purified from cultures expressing the form lacking the N-terminal targeting sequence and 26 C-terminal residues.	Arginine	104-114	carbonic anhydrase 4	Mus musculus	157-178
9435301-7	1998	ERK2 activation could be blocked with a combination of anti-alpha4 and -alpha5 antibodies and an arginine-glycine-aspartic acid (RGD) peptide, while the antibodies or peptide used separately failed to block ERK2 activation.	Arginine	97-105	mitogen activated protein kinase 1	Rattus norvegicus	0-4
12039559-3	2002	Mutation of the arginine proposed to bind 2-oxoglutarate and of the 2His-1-carboxylate iron(II) binding motif in PHD1 dramatically reduces its activity.	Arginine	16-24	egl-9 family hypoxia inducible factor 2	Homo sapiens	113-117
9426066-5	1998	Only two alterations, both at codon 24, have been identified in CDK4: an activating arginine-to-cysteine transition and a germ-line arginine-to-histidine substitution in one French kindred.	Arginine	84-92	cyclin dependent kinase 4	Homo sapiens	64-68
9426066-5	1998	Only two alterations, both at codon 24, have been identified in CDK4: an activating arginine-to-cysteine transition and a germ-line arginine-to-histidine substitution in one French kindred.	Arginine	132-140	cyclin dependent kinase 4	Homo sapiens	64-68
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	120-128	tyrosine aminotransferase	Homo sapiens	105-108
9488156-1	1998	The NO synthases (NOS) generate NO from L-arginine.	Arginine	40-50	nitric oxide synthase 1, neuronal	Mus musculus	4-16
9932348-1	1998	Nitric oxide (NO) is synthetized from L-arginine by the aid of an enzyme--NO synthase (NOS).	Arginine	38-48	nitric oxide synthase 1	Homo sapiens	66-85
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	120-128	tyrosine aminotransferase	Homo sapiens	220-223
9399944-9	1997	In contrast, L-arginine treatment was associated with increased staining for Th2 cytokines IL-4 and IL-10.	Arginine	13-23	interleukin 4	Rattus norvegicus	91-95
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	180-183	tyrosine aminotransferase	Homo sapiens	105-108
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	180-183	tyrosine aminotransferase	Homo sapiens	220-223
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	184-187	tyrosine aminotransferase	Homo sapiens	105-108
9550408-4	1997	In this study we demonstrate that the addition of arginine to V(H) CDR3 of an induced anti-DNA confers the mammalian dsDNA binding characteristic of anti-DNA from lupus mice.	Arginine	50-58	CDR3	Homo sapiens	67-71
12034867-1	2002	A novel secretion pathway originally found in plants has recently been discovered in bacteria and termed TAT, for "twin-arginine translocation," with respect to the presence of an Arg-Arg motif in the signal sequence of TAT-secreted products.	Arginine	184-187	tyrosine aminotransferase	Homo sapiens	220-223
9550408-5	1997	The ability to confer mammalian dsDNA binding is dependent on both the position of the arginine in V(H) CDR3 and the light chain with which the heavy chain is paired, suggesting the light chain plays a more substantial role in DNA binding by this Ab than has previously been reported for other anti-DNA.	Arginine	87-95	CDR3	Homo sapiens	104-108
12067429-1	2002	Exogenous insulin-like growth factor (IGF)-I has been shown to increase growth rate in neonatal pigs while an analogue of IGF-I, long arginine (LR3) IGF-I, has been shown to be more potent than IGF-I in the rat.	Arginine	134-142	insulin like growth factor 1	Sus scrofa	122-127
9426009-6	1997	Using site-directed mutagenesis we demonstrate that the two arginine residues of the EGRR motif conserved in all SRP19 homologues are essential for SRP activity.	Arginine	60-68	signal recognition particle 19	Homo sapiens	113-118
9398350-2	1997	0K-beta2 has the following modifications: (1) all 16 lysines in the wild-type beta2 receptor were mutated to arginines, (2) a FLAG epitope preceded by a cleaved hemagglutinin signal sequence was fused to the amino terminus, and (3) a hexahistidine tail was added to the carboxyl terminus.	Arginine	109-118	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	3-8
12067429-1	2002	Exogenous insulin-like growth factor (IGF)-I has been shown to increase growth rate in neonatal pigs while an analogue of IGF-I, long arginine (LR3) IGF-I, has been shown to be more potent than IGF-I in the rat.	Arginine	134-142	insulin like growth factor 1	Sus scrofa	149-154
12067429-1	2002	Exogenous insulin-like growth factor (IGF)-I has been shown to increase growth rate in neonatal pigs while an analogue of IGF-I, long arginine (LR3) IGF-I, has been shown to be more potent than IGF-I in the rat.	Arginine	134-142	insulin like growth factor 1	Sus scrofa	149-154
12022872-3	2002	Upon incubation with plasmin, TAFIa activity was generated, which was unstable at 37 degrees C. Analysis of the cleavage pattern showed that TAFI was cleaved at Arg(92), releasing the activation peptide from the 35.8-kDa catalytic domain.	Arginine	161-164	plasminogen	Homo sapiens	21-28
9367520-2	1997	To investigate the specificity and target proteins of the arginine-specific mono-ADP-ribosyltransferase (mADP-RT) in rabbit skeletal muscle T-tubules (TT) biotin- or digoxigenin-coupled NAD-derivatives were synthesized.	Arginine	58-66	ecto-ADP-ribosyltransferase 3	Oryctolagus cuniculus	76-103
12022872-3	2002	Upon incubation with plasmin, TAFIa activity was generated, which was unstable at 37 degrees C. Analysis of the cleavage pattern showed that TAFI was cleaved at Arg(92), releasing the activation peptide from the 35.8-kDa catalytic domain.	Arginine	161-164	carboxypeptidase B2	Homo sapiens	30-34
12022872-6	2002	TAFI was also cleaved at Arg(302), Lys(327), and Arg(330), resulting in a approximately 44.3-kDa fragment and several smaller fragments.	Arginine	25-28	carboxypeptidase B2	Homo sapiens	0-4
12022872-6	2002	TAFI was also cleaved at Arg(302), Lys(327), and Arg(330), resulting in a approximately 44.3-kDa fragment and several smaller fragments.	Arginine	49-52	carboxypeptidase B2	Homo sapiens	0-4
9409765-7	1997	Sequencing analysis revealed that the mutant HAC1 gene obtained from the ire15 mutant contained an AAA codon at position 50 instead of the AGA codon observed in the wild-type gene, resulting in the alteration of the aa from Arg to Lys.	Arginine	224-227	transcription factor HAC1	Saccharomyces cerevisiae S288C	45-49
11880366-4	2002	These analyses ultimately identified Asp(149), Arg(151), Gly(207), Tyr(252), and Glu(258) as critical for NIF binding.	Arginine	47-50	S100 calcium binding protein A8	Homo sapiens	106-109
9409765-7	1997	Sequencing analysis revealed that the mutant HAC1 gene obtained from the ire15 mutant contained an AAA codon at position 50 instead of the AGA codon observed in the wild-type gene, resulting in the alteration of the aa from Arg to Lys.	Arginine	224-227	transcription factor HAC1	Saccharomyces cerevisiae S288C	73-78
9353942-8	1997	A lysine residue that is a binding site for pyridoxal phosphate and an arginine residue that is a binding site for the alpha-carboxylate group of the substrate are conserved in ORF3.	Arginine	71-79	hypothetical protein	Escherichia coli	177-181
11994008-4	2002	Following characterization, one analogue, [Bpa(1), Tyr(3), Arg(7), Phe(13)]alpha-factor, was radioiodinated and used as a probe for Ste2p, the GPCR for alpha-factor.	Arginine	59-62	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	132-137
12108552-1	2002	We explored the unique substrate specificity of the primary S, subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from Phenylacetyl-Phe-Ser-Arg-EDDnp, a previously described inhibitor with analgesic and anti-inflammatory activities [Emim et al., Br.	Arginine	132-135	keratin 1	Homo sapiens	100-103
9342184-1	1997	Osteopontin (OPN) is a secreted phosphoprotein that binds to cells via an Arg-Gly-Asp sequence and to mineralized surfaces.	Arginine	74-77	secreted phosphoprotein 1	Mus musculus	0-11
9342184-1	1997	Osteopontin (OPN) is a secreted phosphoprotein that binds to cells via an Arg-Gly-Asp sequence and to mineralized surfaces.	Arginine	74-77	secreted phosphoprotein 1	Mus musculus	13-16
11953390-4	2002	The purpose of this study was to determine if the arginine- and lysine-specific gingipains of P. gingivalis (i.e., HRgpA and RgpB, and Kgp, respectively) were responsible for the degradation of E-cadherin, the cell-cell adhesion protein in the adherens junctions.	Arginine	50-58	cadherin 1	Canis lupus familiaris	194-204
9346432-1	1997	We investigated the L-arginine-induced, regional cerebral blood flow (rCBF) enhancement after different durations of transient focal cerebral ischemia in the rat to determine if L-arginine increases rCBF after transient focal cerebral ischemia.	Arginine	20-30	CCAAT/enhancer binding protein zeta	Rattus norvegicus	70-74
9346432-1	1997	We investigated the L-arginine-induced, regional cerebral blood flow (rCBF) enhancement after different durations of transient focal cerebral ischemia in the rat to determine if L-arginine increases rCBF after transient focal cerebral ischemia.	Arginine	178-188	CCAAT/enhancer binding protein zeta	Rattus norvegicus	199-203
9346432-4	1997	Reactivity of rCBF to L-arginine (300 mg/kg) was measured 45 minutes after reperfusion, and hypercapnia 90 minutes after reperfusion.	Arginine	22-32	CCAAT/enhancer binding protein zeta	Rattus norvegicus	14-18
11953390-7	2002	Incubation of P. gingivalis cells with immunoprecipitated E-cadherin resulted in degradation, whereas prior exposure of P. gingivalis cells to leupeptin and especially acetyl-Leu-Val-Lys-aldehyde (which are arginine- and lysine-specific inhibitors, respectively) reduced this activity.	Arginine	207-215	cadherin 1	Canis lupus familiaris	58-68
9346432-6	1997	Hypercapnia and L-arginine increased rCBF in sham operated controls and on the nonischemic hemispheres.	Arginine	16-26	CCAAT/enhancer binding protein zeta	Rattus norvegicus	37-41
9346432-9	1997	N(omega)-nitro-L-arginine pretreatment partly restored the L-arginine-induced rCBF increase.	Arginine	15-25	CCAAT/enhancer binding protein zeta	Rattus norvegicus	78-82
12019286-7	2002	L-Arginine augmented the decrease in AT(1a) receptor expression.	Arginine	0-10	angiotensin II receptor, type 1a	Rattus norvegicus	37-42
9346432-10	1997	Thus, rCBF increase caused by L-arginine in the reperfusion period was unaffected by 5 minutes of ischemia, but reduced by 20 minutes of ischemia.	Arginine	30-40	CCAAT/enhancer binding protein zeta	Rattus norvegicus	6-10
12162457-3	2002	Experiments with nitric oxide synthase (NOS) inhibition and 15N-labeled L-arginine as NOS substrate verify the origin of trapped NO from L-arginine.	Arginine	137-147	nitric oxide synthase 1, neuronal	Mus musculus	17-38
9315692-2	1997	We have used this strategy to append polyarginine peptides in order to achieve specific binding of the Arg-tag to atomically flat, negatively charged mica surfaces.	Arginine	103-106	MHC class I polypeptide-related sequence A	Homo sapiens	117-121
9315692-3	1997	We show that the model protein, hexaarginine-tagged green fluorescent protein (GFP), binds to mica via its Arg-tag based on ion exchange of naturally occurring potassium cations.	Arginine	107-110	MHC class I polypeptide-related sequence A	Homo sapiens	94-98
12043562-10	2002	The gene sequence exhibits good overall homology to that of rat SRrp86 gene, with 84% and 86% identity over the full-length nucleotide and protein, respectively, and with 96% and 86% identity over the serine-rich domain (RS) or arginine-rich domain (RA), respectively.	Arginine	228-236	splicing regulatory glutamic acid and lysine rich protein 1	Rattus norvegicus	64-70
9306277-12	1997	E. coli STa and L-arginine increased electrogenic Cl- secretion across intact mouse ileum in vitro by releasing nitric oxide and elevating mucosal cyclic GMP.	Arginine	16-26	5'-nucleotidase, cytosolic II	Mus musculus	154-157
12133319-13	2002	(3) MMP-2 and TIMP-1 mRNA levels in the L-arginine group and the asthmatic group were significantly higher than that in the control group [L-arginine group (0.82 +/- 0.11), (0.51 +/- 0.12); asthmatic group (0.68 +/- 0.14), (0.56 +/- 0.10); control group (0.14 +/- 0.03), (0.11 +/- 0.05), respectively].	Arginine	40-50	matrix metallopeptidase 2	Rattus norvegicus	4-9
12133319-14	2002	The difference in the MMP-2 mRNA levels was significant between the L-arginine group and the asthmatic group (P &lt; 0.05), but the difference in the TIMP-1 mRNA levels between the two groups was not statistically significant.	Arginine	68-78	matrix metallopeptidase 2	Rattus norvegicus	22-27
12133319-16	2002	(4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P &lt; 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P &gt; 0.05).	Arginine	111-121	matrix metallopeptidase 2	Rattus norvegicus	61-66
11955056-0	2002	Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor.	Arginine	71-79	oxytocin receptor	Homo sapiens	111-128
9300641-3	1997	As many extracellular matrix (ECM) molecules contain the conserved amino acid sequence arg-gly-asp-ser (RGDS) at the integrin recognition site, integrin-ECM binding can be disrupted using RGDS peptides.	Arginine	87-90	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	104-108
9300641-3	1997	As many extracellular matrix (ECM) molecules contain the conserved amino acid sequence arg-gly-asp-ser (RGDS) at the integrin recognition site, integrin-ECM binding can be disrupted using RGDS peptides.	Arginine	87-90	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	188-192
11955056-9	2002	However, the importance of Arg(34) is restricted to agonist interaction with the OTR, as it was not required for binding peptide antagonist or non-peptide antagonist.	Arginine	27-30	oxytocin receptor	Homo sapiens	81-84
11799113-6	2002	Following transport to the acidified TGN/endosomal compartments, furin cleaves the bound propeptide at a second, internal P1/P6 Arg site (-Arg-Gly-Val(72)-Thr-Lys-Arg(75)-) resulting in propeptide dissociation and enzyme activation.	Arginine	128-131	furin, paired basic amino acid cleaving enzyme	Homo sapiens	65-70
9235940-5	1997	Phosphorylation of DNase I oligosaccharides decreased from 12.6% to 2.3% when Lys-50, Lys-124, and Arg-27 were mutated to alanines, indicating that these residues are required for the basal level of phosphorylation.	Arginine	99-102	deoxyribonuclease 1	Bos taurus	19-26
11799113-6	2002	Following transport to the acidified TGN/endosomal compartments, furin cleaves the bound propeptide at a second, internal P1/P6 Arg site (-Arg-Gly-Val(72)-Thr-Lys-Arg(75)-) resulting in propeptide dissociation and enzyme activation.	Arginine	139-142	furin, paired basic amino acid cleaving enzyme	Homo sapiens	65-70
11799113-9	2002	Altering this preference by converting the internal site to a canonical P1/P4 Arg motif (Val(72) --&gt; Arg) caused ER retention and blocked activation of furin, demonstrating that the structure of the furin propeptide mediates folding of the enzyme and directs its pH-regulated, compartment-specific activation in vivo.	Arginine	78-81	furin, paired basic amino acid cleaving enzyme	Homo sapiens	155-160
9235940-0	1997	The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues.	Arginine	102-110	deoxyribonuclease 1	Bos taurus	30-37
11799113-9	2002	Altering this preference by converting the internal site to a canonical P1/P4 Arg motif (Val(72) --&gt; Arg) caused ER retention and blocked activation of furin, demonstrating that the structure of the furin propeptide mediates folding of the enzyme and directs its pH-regulated, compartment-specific activation in vivo.	Arginine	78-81	furin, paired basic amino acid cleaving enzyme	Homo sapiens	202-207
11799113-9	2002	Altering this preference by converting the internal site to a canonical P1/P4 Arg motif (Val(72) --&gt; Arg) caused ER retention and blocked activation of furin, demonstrating that the structure of the furin propeptide mediates folding of the enzyme and directs its pH-regulated, compartment-specific activation in vivo.	Arginine	104-107	furin, paired basic amino acid cleaving enzyme	Homo sapiens	155-160
11799113-9	2002	Altering this preference by converting the internal site to a canonical P1/P4 Arg motif (Val(72) --&gt; Arg) caused ER retention and blocked activation of furin, demonstrating that the structure of the furin propeptide mediates folding of the enzyme and directs its pH-regulated, compartment-specific activation in vivo.	Arginine	104-107	furin, paired basic amino acid cleaving enzyme	Homo sapiens	202-207
11942918-4	2002	The nitric oxide synthase (NOS) activity was estimated via formation of L-citrulline from L-arginine and histochemically with the nicotinamide-adenine dinucleotide phosphate diaphorase (NADPH-d) nitro blue technique.	Arginine	90-100	nitric oxide synthase, inducible	Cavia porcellus	4-25
9218440-6	1997	Our previous studies have identified a mutation at position 332 within Drosophila TBP that changes a highly conserved arginine residue to a histidine residue, which renders it specifically defective in its ability to support RNA polymerase III transcription in S-2 cells (Trivedi, A., Vilalta, A., Gopalan, S., and Johnson, D. L. (1996) Mol.	Arginine	118-126	TATA binding protein	Drosophila melanogaster	82-85
12021143-3	2002	HLA genotyping identified several polymorphic residues of the DQalpha and DQbeta to be either positively or negatively associated with IDDM, including Arg 52 DQalpha and Asp 57 DQbeta.	Arginine	151-154	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-3
9263921-2	1997	Arginine and other amino acids are secretagogues for growth hormone and prolactin in the intact animal, but the mechanism of action is unclear.	Arginine	0-8	gonadotropin releasing hormone receptor	Rattus norvegicus	53-67
9237680-0	1997	Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis.	Arginine	89-97	Ort1p	Saccharomyces cerevisiae S288C	28-34
11943934-2	2002	These mutations affect the APC cleavage site at arginine (Arg) 306 in the heavy chain of activated FV.	Arginine	48-56	APC regulator of WNT signaling pathway	Homo sapiens	27-30
9205124-8	1997	The human putative cortistatin peptide has an arginine for lysine substitution, compared to the rat and mouse products, and is N-terminally extended by 3 amino acids.	Arginine	46-54	cortistatin	Homo sapiens	19-30
11943934-2	2002	These mutations affect the APC cleavage site at arginine (Arg) 306 in the heavy chain of activated FV.	Arginine	58-61	APC regulator of WNT signaling pathway	Homo sapiens	27-30
11933209-4	2002	The mutation (1084C&gt;T) changes the amino acid arginine at position 362 to the translation stop codon TGA (R362X) resulting in a predicted truncated protein lacking three of the four zinc finger domains necessary for correct functioning of the gene.	Arginine	49-57	T-box transcription factor 1	Homo sapiens	104-107
9182720-6	1997	In the model the disulphide bond is in close proximity to the invariant Caf1M Arg-23 and Lys-142 residues that are assumed to anchor the C-terminal group of the subunit.	Arginine	78-81	F1 capsule protein	Yersinia pestis	72-77
11836629-6	2002	Aldosterone response of ZG cells to 10(-7) M PACAP38 was unaffected by the PAC1-antagonist (A) PACAP(6-38), and significantly decreased by the VPAC1-A [Ac-His(1),D-Phe(2),Lys(15),Arg(16)]VIP(3-7) GRF(8-27)-NH(2).	Arginine	179-182	adenylate cyclase activating polypeptide 1	Rattus norvegicus	45-50
9220146-2	1997	In particular: a) intrathymic transplant of pineal gland or treatment with melatonin; b) implantation of a growth hormone secreting tumor cell line or treatment with exogenous growth hormone; c) castration or treatment with exogenous LH-RH; d) treatment with exogenous thyroxine or triiodothyronine, and e) nutritional interventions such as arginine or zinc supplementation.	Arginine	341-349	gonadotropin releasing hormone 1	Homo sapiens	234-239
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Arginine	198-201	carboxypeptidase B2	Homo sapiens	64-105
11914032-1	2002	Arginine decarboxylase (ADC) and agmatinase are part of an operon in Escherichia coli, which constitutes the primary pathway of polyamine synthesis from arginine.	Arginine	153-161	agmatinase	Homo sapiens	33-43
11855982-1	2002	The extracellular loop 3 (ECL3) of the mammalian gonadotropin-releasing hormone receptor (GnRH-R) contains an acidic amino acid (Glu(301) in the mouse GnRH-R) that confers agonist selectivity for Arg(8) in mammalian GnRH.	Arginine	196-199	gonadotropin releasing hormone receptor	Homo sapiens	49-88
9171884-6	1997	Analogue Ac-Nle-c[Asp-His-Phe7-Arg-Trp-Ala-Lys]-NH2 resulted in micromolar binding affinity (or greater) at the hMC3R and hMC5R, demonstrating the importance of D-Phe7 for ligand binding potency at these receptors.	Arginine	31-34	melanocortin 3 receptor	Homo sapiens	112-117
11855982-1	2002	The extracellular loop 3 (ECL3) of the mammalian gonadotropin-releasing hormone receptor (GnRH-R) contains an acidic amino acid (Glu(301) in the mouse GnRH-R) that confers agonist selectivity for Arg(8) in mammalian GnRH.	Arginine	196-199	gonadotropin releasing hormone receptor	Homo sapiens	90-96
11820786-0	2002	Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO.	Arginine	0-8	macrophage receptor with collagenous structure	Homo sapiens	113-118
9169591-6	1997	With the aid of protein engineering, a modified pro-urokinase has been prepared in which the activation sequence normally recognized by plasmin (Pro-Arg-Phe-Lys upward arrowIle-Ile-Gly-Gly) has been replaced by a sequence expected to be recognized and hydrolysed by many MMPs (Arg-Pro-Leu-Gly upward arrowIle-Ile-Gly-Gly).	Arginine	149-152	plasminogen	Homo sapiens	136-143
11820786-3	2002	In the present study, we generated several human and mouse MARCO variants with deletions or single amino acid substitutions and localized the primary bacteria-binding region to domain V. Furthermore, analysis of the MARCO variants containing only portions of domain V demonstrated a crucial role for an arginine-rich segment for this function.	Arginine	303-311	macrophage receptor with collagenous structure	Homo sapiens	216-221
11830541-0	2002	Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele.	Arginine	73-76	fibroblast growth factor receptor 4	Homo sapiens	67-72
9165092-1	1997	Lysine was substituted for a conserved arginine at position 199 of the schistosomal hypoxanthine phosphoribosyltransferase (HPRT).	Arginine	39-47	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	84-122
9165092-1	1997	Lysine was substituted for a conserved arginine at position 199 of the schistosomal hypoxanthine phosphoribosyltransferase (HPRT).	Arginine	39-47	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	124-128
11830541-6	2002	Moreover, the FGFR4 Arg(388) allele was associated with early lymph node metastasis and advanced tumor-node-metastasis (TNM) stage in 82 colon cancer patients.	Arginine	20-23	fibroblast growth factor receptor 4	Homo sapiens	14-19
11830541-7	2002	Consistent with this finding, MDA-MB-231 mammary tumor cells expressing FGFR4 Arg(388) exhibited increased motility relative to cells expressing the FGFR4 Gly(388) isotype.	Arginine	78-81	fibroblast growth factor receptor 4	Homo sapiens	72-77
11830541-8	2002	Our results support the conclusion that the FGFR4 Arg(388) allele represents a determinant that is innocuous in healthy individuals but predisposes cancer patients for significantly accelerated disease progression.	Arginine	50-53	fibroblast growth factor receptor 4	Homo sapiens	44-49
11906607-4	2002	Substitution of Arg8 with N(G)-alkylated Arg derivatives or homolysine (Hlys) maintained the subnanomolar affinity of NT(8-13) to the hNTR-1.	Arginine	16-19	tuftelin interacting protein 11	Homo sapiens	134-140
11849379-0	2002	L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with L-NMMA.	Arginine	0-10	GATA binding protein 2	Homo sapiens	75-81
11849379-13	2002	CONCLUSION: L-arginine rescues decreased erythropoietin gene expression by stimulating GATA-2 with NG-monomethyl-L-arginine.	Arginine	12-22	GATA binding protein 2	Homo sapiens	87-93
11825621-8	2002	Each of these serine residues in SPR was found in the consensus sequence (Arg-X-X-Ser/Thr) of the phosphorylation site.	Arginine	74-77	sepiapterin reductase	Homo sapiens	33-36
11798170-0	2002	Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes.	Arginine	15-23	nucleophosmin 1	Homo sapiens	36-49
11856371-8	2002	CONCLUSIONS: Taken together, these results indicate that PRMT1/BTG proteins could play a key role in the arginine methylation-mediated signalling pathway as well as in neuronal differentiation.	Arginine	105-113	protein arginine methyltransferase 1	Rattus norvegicus	57-62
11891849-7	2002	We propose that phosphorylation of aPKC at Tyr256 induces a conformation, whereby, the arginine-rich NLS is exposed, which then binds importin-beta leading to import of aPKC into the nucleus.	Arginine	87-95	karyopherin subunit beta 1	Rattus norvegicus	134-147
11870920-4	2002	The most frequently selected and IL5-competed CCSL-phage contain charged residues Arg and Glu in their turn sequences, in this regard resembling a beta strand sequence in the "CD turn" region, of IL5, that has been proposed to present a key determinant for IL5 receptor alpha chain recognition.	Arginine	82-85	interleukin 5	Homo sapiens	33-36
11870920-4	2002	The most frequently selected and IL5-competed CCSL-phage contain charged residues Arg and Glu in their turn sequences, in this regard resembling a beta strand sequence in the "CD turn" region, of IL5, that has been proposed to present a key determinant for IL5 receptor alpha chain recognition.	Arginine	82-85	interleukin 5	Homo sapiens	196-199
11870920-4	2002	The most frequently selected and IL5-competed CCSL-phage contain charged residues Arg and Glu in their turn sequences, in this regard resembling a beta strand sequence in the "CD turn" region, of IL5, that has been proposed to present a key determinant for IL5 receptor alpha chain recognition.	Arginine	82-85	interleukin 5	Homo sapiens	196-199
11731285-3	2002	The T9176G mutation changes a highly conserved leucine residue to an arginine in subunit 6 of ATPase and is maternally inherited like mutations in the other mitochondrial genes.	Arginine	69-77	dynein axonemal heavy chain 8	Homo sapiens	94-100
11795274-4	2001	These observations suggest that the 563Ser/Ser genotype and 670Arg/Arg genotype of PECAM-1 are novel genetic risk factors of myocardial infarction in Japanese.	Arginine	63-66	platelet and endothelial cell adhesion molecule 1	Homo sapiens	83-90
11713266-3	2001	SMN binds preferentially and directly to the symmetrical dimethylarginine (sDMA)-modified arginine- and glycine-rich (RG-rich) domains of SmD1 and SmD3.	Arginine	65-73	small nuclear ribonucleoprotein D3 polypeptide	Homo sapiens	147-151
11723235-1	2001	Mammalian gonadotropin-releasing hormone (GnRH) receptors preferentially bind mammalian GnRH, which has Arg in position eight.	Arginine	104-107	gonadotropin releasing hormone 1	Homo sapiens	10-40
11723235-1	2001	Mammalian gonadotropin-releasing hormone (GnRH) receptors preferentially bind mammalian GnRH, which has Arg in position eight.	Arginine	104-107	gonadotropin releasing hormone 1	Homo sapiens	42-46
11723235-1	2001	Mammalian gonadotropin-releasing hormone (GnRH) receptors preferentially bind mammalian GnRH, which has Arg in position eight.	Arginine	104-107	gonadotropin releasing hormone 1	Homo sapiens	88-92
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Arginine	88-91	gonadotropin releasing hormone 1	Homo sapiens	70-74
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Arginine	88-91	gonadotropin releasing hormone receptor	Homo sapiens	143-156
11723235-3	2001	We have confirmed that Asp(7.32(302)) confers selectivity of the human GnRH receptor for Arg(8) of GnRH and investigated the mechanism of this specificity using site-directed mutagenesis and ligand modification.	Arginine	89-92	gonadotropin releasing hormone receptor	Homo sapiens	71-84
11723235-3	2001	We have confirmed that Asp(7.32(302)) confers selectivity of the human GnRH receptor for Arg(8) of GnRH and investigated the mechanism of this specificity using site-directed mutagenesis and ligand modification.	Arginine	89-92	gonadotropin releasing hormone 1	Homo sapiens	71-75
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Arginine	22-25	gonadotropin releasing hormone 1	Homo sapiens	90-94
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Arginine	22-25	gonadotropin releasing hormone receptor	Homo sapiens	226-239
11723235-4	2001	We find that although Arg(8) and Asp(7.32(302)) are required for high-affinity binding of GnRH, conformationally constrained peptides, with D-amino acid substitutions in position six or with a 6,7 gamma-lactam, bind the human GnRH receptor with high affinity, which is independent of the presence of Asp(7.32(302)) in the receptor or Arg(8) in the ligand.	Arginine	334-337	gonadotropin releasing hormone 1	Homo sapiens	90-94
11723235-6	2001	This suggests that the Arg(8) and Asp(7.32(302)) side chains interact to induce a high affinity conformation of native GnRH.	Arginine	23-26	gonadotropin releasing hormone 1	Homo sapiens	119-123
11723235-9	2001	We propose that Arg(8) interacts transiently with Asp(7.32(302)) to induce a high-affinity ligand conformation of GnRH, which then interacts with a binding pocket that is common for both constrained and unconstrained analogs of GnRH.	Arginine	16-19	gonadotropin releasing hormone 1	Homo sapiens	114-118
11723235-9	2001	We propose that Arg(8) interacts transiently with Asp(7.32(302)) to induce a high-affinity ligand conformation of GnRH, which then interacts with a binding pocket that is common for both constrained and unconstrained analogs of GnRH.	Arginine	16-19	gonadotropin releasing hormone 1	Homo sapiens	228-232
11749046-0	2001	Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation.	Arginine	122-130	guanidinoacetate N-methyltransferase	Homo sapiens	23-57
11731013-1	2001	Nitric oxide synthases (NOS) are heme-containing enzymes which catalyse the oxidation of L-arginine to nitric oxide and L-citrulline.	Arginine	89-99	nitric oxide synthase 3	Sus scrofa	0-22
11597915-2	2001	L-Arg is transported into bovine pulmonary arterial endothelial cells (BPAECs) by cationic amino acid transporter-2 (CAT-2).	Arginine	0-5	solute carrier family 7 member 2	Bos taurus	82-115
9125528-1	1997	When isolated from central nervous system myelin, myelin basic protein (MBP) exhibits charge microheterogeneity due to posttranslational deamidation, phosphorylation, and deimination of arginine to citrulline.	Arginine	186-194	myelin basic protein	Homo sapiens	50-70
9125528-1	1997	When isolated from central nervous system myelin, myelin basic protein (MBP) exhibits charge microheterogeneity due to posttranslational deamidation, phosphorylation, and deimination of arginine to citrulline.	Arginine	186-194	myelin basic protein	Homo sapiens	72-75
11597915-2	2001	L-Arg is transported into bovine pulmonary arterial endothelial cells (BPAECs) by cationic amino acid transporter-2 (CAT-2).	Arginine	0-5	solute carrier family 7 member 2	Bos taurus	117-122
11597915-11	2001	This suggests that induction of NOS and/or AR is linked to induction of CAT-2 in BPAECs and may represent a mechanism for maintaining L-Arg availability to NOS and/or AR.	Arginine	134-139	solute carrier family 7 member 2	Bos taurus	72-77
11602754-7	2001	We propose that the high degree of sequence conservation at Gly-572 and Arg-579 may result from selective pressures imposed by prefusogenic conformations of the HIV-1 envelope glycoprotein.	Arginine	72-75	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	167-188
9092516-6	1997	The basic cluster Arg-31/Arg-32/Arg-33 has been identified as an important component of the heparin binding site.	Arginine	25-28	activity regulated cytoskeleton associated protein	Homo sapiens	18-24
9092516-7	1997	Mutations of these residues, and of Arg-70 as well, decrease both the affinity of Ang for heparin-Sepharose and the capacity of Ang to support cell adhesion.	Arginine	36-39	angiogenin	Homo sapiens	82-85
9092516-7	1997	Mutations of these residues, and of Arg-70 as well, decrease both the affinity of Ang for heparin-Sepharose and the capacity of Ang to support cell adhesion.	Arginine	36-39	angiogenin	Homo sapiens	128-131
11827166-5	2001	The former mainly involve Rev"s arginine-rich domain (residues 35-50) in helix-2, while the latter are mostly mediated by residues 12-24 of helix-1.	Arginine	32-40	Rev	Human immunodeficiency virus 1	26-29
9092534-6	1997	Ionic strength increases the Ki of the elastase-suramin complex in a way that suggests that four of the six sulfonate groups of suramin form ionic interactions with basic residues of the enzyme and that at saturation almost all arginines of elastase form salt bridges with suramin.	Arginine	228-237	elastase, neutrophil expressed	Homo sapiens	39-47
11720283-0	2001	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B" and the Sm-like protein LSm4, and their interaction with the SMN protein.	Arginine	29-37	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	63-77
9104579-5	1997	The recently reported negative association with DQA1 alleles encoding phenylalanine at amino acid 25, leucine at amino acid 69 and arginine at amino acid 52 was not found in this study, although there was a trend towards reduced phenylalanine at amino acid 25.	Arginine	131-139	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	48-52
11720283-0	2001	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B" and the Sm-like protein LSm4, and their interaction with the SMN protein.	Arginine	29-37	survival of motor neuron 1, telomeric	Homo sapiens	140-143
11720283-3	2001	Symmetrically dimethylated arginines (sDMA) have until now been confined to the myelin basic protein MBP and the Sm proteins D1 and D3.	Arginine	27-36	myelin basic protein	Homo sapiens	101-104
11753800-2	2001	Recently, the genetic defect has been mapped to chromosome 7q35 and consists mainly of a point mutation in exon 3 of the cationic trypsinogen gene which causes an Arg(CGC)-His(CAC) substitution at residue 117.	Arginine	163-166	serine protease 1	Homo sapiens	121-141
9208415-9	1997	The previously acquired folate depletion could affect normal appositional function of myelin basic protein molecules due to insufficient methylation of arginine in position 107.	Arginine	152-160	myelin basic protein	Homo sapiens	86-106
11514347-6	2001	Functional analysis of potential OPN interactions with conceptus and endometrial integrins was performed on LE and Tr cells in vitro using beads coated with OPN, poly-L-lysine, or recombinant OPN in which the Arg-Gly-Asp sequence was replaced with RGE or RAD.	Arginine	209-212	osteopontin	Ovis aries	33-36
9042931-9	1997	Our results indicate that the combination DQA1#52 (Arg predisposing) DQB1#57 (Asp protective), which has been proposed as an important IDDM agent, does not include all the predisposing elements.	Arginine	51-54	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	42-46
11577583-5	2001	OTHER COMPOUNDS WITH INTERESTING PROPERTIES: Other compounds also have interesting properties for preventing ischemia-reperfusion lesions: a specific metallo-protease inhibitor, L-arginine, a selective agonist of the PGE1 receptor, estrogens, low-dose cyclosporine, and certain immunosuppressors (FTY 720, anti CD28, anti B7-1), and rPSGL-Ig ligand.	Arginine	178-188	CD28 molecule	Homo sapiens	311-315
9079806-5	1997	ILT1 has an arginine within the transmembrane region, followed by a short cytoplasmic tail, similar to human Fc alphaRI and bovine Fc gamma2R.	Arginine	12-20	leukocyte immunoglobulin like receptor A2	Homo sapiens	0-4
11399767-5	2001	The nuclear localization of Tyk2 requires a nuclear localization signal-like motif rich in arginine residues that maps within the region mediating interaction with cytokine receptors.	Arginine	91-99	tyrosine kinase 2	Homo sapiens	28-32
9091345-1	1997	OBJECTIVE: To examine the potential role of the L-arginine:nitric oxide pathway in hCG-induced ovulation in the rabbit.	Arginine	48-58	hypertrichosis 2 (generalised, congenital)	Homo sapiens	83-86
11489750-11	2001	On the basis of microsomal enzyme activities from heterozygotes, CYP1A1*1/2A, CYP1A1*1/2B, CYP1A1*1/4, and AHR(554) Arg/Lys variants do not appear to significantly affect CYP1A1 activities in human lung, and we observed no association between CYP1A1 activity and the GSTM1-null polymorphism.	Arginine	116-119	aryl hydrocarbon receptor	Homo sapiens	107-110
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Arginine	160-168	interferon alpha 2	Homo sapiens	17-27
11481035-7	2001	The structure and ligand geometry of the high-spin ferriheme in arginine-bound neuronal NOS are essentially identical to those of the N(omega)-hydroxy-L-arginine-bound form and only slightly affected by the divalent cation inhibitor of constitutive NOS.	Arginine	64-72	nitric oxide synthase 1	Homo sapiens	79-91
11455018-8	2001	CYP2J2 transfection attenuated the HR-induced increase in 8-iso-prostaglandin F(2alpha) (p &lt; 0.05) and decreased the amount of extracellular superoxide detected by cytochrome c reduction under normoxic conditions (p &lt; 0.05) but did not significantly affect HR-induced decreases in eNOS expression, L-arginine uptake and conversion, and nitrite production.	Arginine	304-314	cytochrome P450 2J2	Bos taurus	0-6
9074788-9	1997	Additionally, naturally occurring Arg to Trp (R231W)-mutated CPX has been also expressed in E. coli and further characterized.	Arginine	34-37	coproporphyrinogen oxidase	Homo sapiens	61-64
11514616-3	2001	Deletion and mutational analysis with the use of GFP-tagged SNG-1 has defined a 38 amino acid sequence within the C terminus of SNG-1 and a single arginine in the cytoplasmic loop between transmembrane domain 2 and 3 that are required for SNG-1 localization.	Arginine	147-155	Synaptogyrin homolog 1	Caenorhabditis elegans	60-65
9000709-2	1997	We typed 285 IDDM patients and 337 HLA-DRB1-DQA1-DQB1 genotypically matched control subjects from an ethnically homogeneous population for both the G/T polymorphism in intron 6 of the LMP7 gene and the Arg-His polymorphism in the LMP2 gene.	Arginine	202-205	proteasome 20S subunit beta 8	Homo sapiens	184-188
9041652-5	1997	Structure-function analysis of the human glucose-6-phosphatase has shown that two of the conserved residues (the first domain arginine and the central domain histidine) are essential for enzyme activity.	Arginine	126-134	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	41-62
11505268-5	2001	RESULTS: The results showed that the APC gene of explant cultured cells from OSF patients (8/8) had a CGA-to-GGA transition mutation at codon 498 that resulted in an Arg-to-Gly missense mutation (P &lt;.01).	Arginine	166-169	APC regulator of WNT signaling pathway	Homo sapiens	37-40
9002937-3	1997	The observation that a common functional polymorphism of Fc gamma RIIA, involving either an arginine (R) or histidine (H) at amino acid 131, may underlie disease susceptibility prompted us to investigate the prevalence of receptor isoforms in patients with HIT and HITT.	Arginine	92-100	Fc gamma receptor IIa	Homo sapiens	57-70
11467936-8	2001	The C907T mutation in Lec1A.3E and Lec1A.5J converts an arginine conserved in all GlcNAc-TIs to a tryptophan at amino acid 303, altering interactions that are important in stabilizing a critical structural element in rabbit GlcNAc-TI.	Arginine	56-64	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Oryctolagus cuniculus	82-91
11437384-1	2001	Ni(2+), a toxic and carcinogenic pollutant and one of the leading causes of contact dermatitis, is shown to inhibit neuronal nitric oxide synthase (nNOS) in a competitive, reversible manner with respect to the substrate l-arginine (K(i) = 30 +/- 4 microM).	Arginine	220-230	nitric oxide synthase 1	Homo sapiens	148-152
9028041-7	1997	The purified enzyme hydrolyzed Gly-Arg-pNA, a model substrate for DAP I, and Arg-Arg-MNA, a model substrate for DAP III.	Arginine	35-38	death associated protein	Homo sapiens	66-69
9028041-7	1997	The purified enzyme hydrolyzed Gly-Arg-pNA, a model substrate for DAP I, and Arg-Arg-MNA, a model substrate for DAP III.	Arginine	35-38	death associated protein	Homo sapiens	112-115
9028041-7	1997	The purified enzyme hydrolyzed Gly-Arg-pNA, a model substrate for DAP I, and Arg-Arg-MNA, a model substrate for DAP III.	Arginine	77-80	death associated protein	Homo sapiens	112-115
11437384-4	2001	Overall, the action profile of Ni(2+) was suggestive of an unusual, double-acting inhibitor of nNOS affecting l-arginine-binding and Ca(2+)/CaM-dependent enzyme activation.	Arginine	110-120	nitric oxide synthase 1	Homo sapiens	95-99
11412004-0	2001	Renaturation and stabilization of the telomere-binding activity of Saccharomyces Cdc13(451-693)p by L-arginine.	Arginine	100-110	telomere-binding protein CDC13	Saccharomyces cerevisiae S288C	81-86
9292247-1	1997	Nitric oxide synthase (NOS), the enzyme that catalyzes the formation of nitric oxide from L-arginine, exists in three major isoforms, neuronal, endothelial, and immunologic.	Arginine	90-100	nitric oxide synthase 1	Homo sapiens	0-21
11412004-4	2001	Here we used recombinant Cdc13(451-693)p as example to show the presence of l-arginine during renaturation greatly enhanced the renaturation efficiency.	Arginine	76-86	telomere-binding protein CDC13	Saccharomyces cerevisiae S288C	25-30
11412004-8	2001	Renaturation of Cdc13(451-693)p to the active form was achieved by dialyzing denatured protein in the presence of l-arginine.	Arginine	114-124	telomere-binding protein CDC13	Saccharomyces cerevisiae S288C	16-21
8990085-3	1997	We observed that in one prototypic anti-DNA antibody, 3H9, a suitable CDR3 conformation is essential for DNA binding and depends on arginine.	Arginine	132-140	CDR3	Homo sapiens	70-74
8990085-4	1997	In addition, arginines at any of five positions in CDR1, CDR2, or FWR3 of the heavy chain contribute contacts with the antigen.	Arginine	13-22	cerebellar degeneration related protein 2	Homo sapiens	57-61
11412004-9	2001	Moreover, the presence of l-arginine was also helped in maintaining the telomere-binding activity of Cdc13(451-693)p. Taking together, l-arginine might have a general application in renaturation of insoluble aggregates.	Arginine	26-36	telomere-binding protein CDC13	Saccharomyces cerevisiae S288C	101-106
11412004-9	2001	Moreover, the presence of l-arginine was also helped in maintaining the telomere-binding activity of Cdc13(451-693)p. Taking together, l-arginine might have a general application in renaturation of insoluble aggregates.	Arginine	135-145	telomere-binding protein CDC13	Saccharomyces cerevisiae S288C	101-106
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	24-27	mitogen-activated protein kinase 12	Homo sapiens	139-147
8988010-11	1996	Most of the binding data are explained by a model in which nNOS dimers accommodate two identical BH4- and Arg/L-NNA-binding sites, with cooperativity between Arg- and BH4-binding and anticooperativity between the BH4-binding sites.	Arginine	106-109	nitric oxide synthase 1	Homo sapiens	59-63
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	24-27	cyclin dependent kinase 2	Homo sapiens	149-153
8988010-11	1996	Most of the binding data are explained by a model in which nNOS dimers accommodate two identical BH4- and Arg/L-NNA-binding sites, with cooperativity between Arg- and BH4-binding and anticooperativity between the BH4-binding sites.	Arginine	158-161	nitric oxide synthase 1	Homo sapiens	59-63
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	32-35	mitogen-activated protein kinase 12	Homo sapiens	139-147
11427888-5	2001	A phosphate ion held by Arg 96, Arg 180 and Lys 205 occupies the same position as the phosphate group of the phosphothreonine in activated p38gamma, CDK2 or ERK2.	Arginine	32-35	cyclin dependent kinase 2	Homo sapiens	149-153
11412100-3	2001	Substitution in Ira2p of the arginine following the arginine finger with alanine, the residue found in the corresponding position of p120-GAP, or by glycine as found in neurofibromin, evokes a low but significant stimulation of Ha-Ras GTPase.	Arginine	29-37	RAS p21 protein activator 1	Homo sapiens	133-141
8955074-1	1996	Neuronal nitric-oxide synthase (NOS-1) is a hemeprotein that generates NO and citrulline from L-arginine, O2, and NADPH.	Arginine	94-104	nitric oxide synthase 1	Homo sapiens	32-37
8955074-8	1996	In the presence of L-arginine, the rates of NO synthesis and NADPH oxidation were proportional to the O2 concentration over a much broader range (estimated KmO2 approximately 400 microM, saturation at approximately 800 microM), indicating that ferrous-NO complex formation altered the O2 response of NOS-1.	Arginine	19-29	nitric oxide synthase 1	Homo sapiens	300-305
11309403-0	2001	Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va. Proteolytic inactivation of activated factor V (FVa) by activated protein C (APC) is a key reaction in the regulation of hemostasis.	Arginine	115-118	APC regulator of WNT signaling pathway	Homo sapiens	69-88
8946838-5	1996	We previously reported that Tat is a direct angiogenic factor and noted the Tat arginine- and lysine-rich sequence is similar to that of other potent angiogenic growth factors, such as vascular endothelial growth factor-A (VEGF-A).	Arginine	80-88	tyrosine aminotransferase	Homo sapiens	76-79
8808595-2	1996	Two unrelated CDGS type II patients are shown to have point mutations (one patient having Ser-->Phe and the other having His-->Arg) in the catalytic domain of the gene MGAT2, encoding UDP-GlcNAc:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (GnT II), an enzyme essential for biosynthesis of complex Asn-linked glycans.	Arginine	127-130	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	168-173
11309403-2	2001	Lysine residues in APC at positions 37, 38, and 39 form a secondary binding site for FVa, which is important for cleavage of FVa at Arg-506 while having no effect on Arg-306 cleavage.	Arginine	132-135	APC regulator of WNT signaling pathway	Homo sapiens	19-22
11309403-3	2001	In contrast, topological neighbors Lys-62, Lys-63, and Arg-74 in APC appear of minor importance in FVa degradation.	Arginine	55-58	APC regulator of WNT signaling pathway	Homo sapiens	65-68
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Arginine	47-50	ectodysplasin A	Homo sapiens	20-23
9015668-8	1996	Interestingly, the frequency of DQB1*non-Asp-57 and DQA1*Arg-52 alleles in the Korean adult control population was similar to that of US Caucasians (DQB1*non-Asp-57: 0.431 vs. 0.475; DQA1*Arg-52: 0.492 vs. 0.463).	Arginine	57-60	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	52-56
9015679-2	1996	The WHO DiaMond Molecular Epidemiology Sub-Project is testing the hypothesis that the geographic differences in IDDM incidence reflect population variation in the frequency of IDDM susceptibility genes (i.e., DQA1 and DQB1 alleles with sequences coding for arginine (R) in position 52 of the DQ alpha-chain, and an amino acid other than aspartic acid (ND) in position 57 of the DQ beta-chain, respectively) using a standardized case-control design.	Arginine	257-265	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	209-213
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Arginine	55-58	ectodysplasin A	Homo sapiens	20-23
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Arginine	55-58	ectodysplasin A	Homo sapiens	20-23
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Arginine	55-58	ectodysplasin A	Homo sapiens	20-23
11416205-3	2001	The stalk region of EDA contains the sequence -Arg-Val-Arg-Arg156-Asn-Lys-Arg159-, representing overlapping consensus cleavage sites (Arg-X-Lys/Arg-Arg( downward arrow)) for the proprotein convertase furin.	Arginine	55-58	ectodysplasin A	Homo sapiens	20-23
21153111-7	1996	However, some ubiquitin residues known to function in the ligation (Arg-54) to targeted proteins and in the processing of conjugates through the proteasome (His-68), have been lost through mutation in bUCRP.	Arginine	68-71	ubiquitin	Bos taurus	14-23
11416205-6	2001	Here we show that the 50-kDa EDA parent molecule is cleaved at -Arg156Asn-Lys-Arg(159 downward arrow)- to release the soluble C-terminal fragment containing the TNF core domain.	Arginine	64-67	ectodysplasin A	Homo sapiens	29-32
11278906-0	2001	Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein.	Arginine	39-47	EWS RNA binding protein 1	Homo sapiens	78-81
8892385-4	1996	The findings suggest that (1) arginine decarboxylation is transiently increased during development and after ischemia in parallel to ornithine decarboxylase activity.	Arginine	30-38	ornithine decarboxylase 1	Homo sapiens	133-156
8892385-5	1996	(2) Arginine decarboxylation reaction is catalyzed by ornithine decarboxylase.	Arginine	4-12	ornithine decarboxylase 1	Homo sapiens	54-77
11342641-2	2001	CPN cleaves the carboxyl-terminal amino acids arginine and lysine from biologically active peptides such as complement anaphylatoxins, kinins, and fibrinopeptides.	Arginine	46-54	carboxypeptidase N, polypeptide 1	Mus musculus	0-3
11325793-7	2001	Within the muscarinic M(2) receptor gene, we identified two degenerate single base substitutions (1197T--&gt;C, Thr--&gt;Thr and 976A--&gt;C, Arg--&gt;Arg) in one random and one asthmatic sample respectively.	Arginine	142-145	cholinergic receptor muscarinic 2	Homo sapiens	11-35
8822954-7	1996	We also identified GPI Kinki as a compound heterozygote of 1124ACA--&gt;AGA(375Thr--&gt;Arg)/ 1615GAC--&gt;AAC(539Asp--&gt;Asn).	Arginine	88-91	glucose-6-phosphate isomerase	Homo sapiens	19-22
11325793-7	2001	Within the muscarinic M(2) receptor gene, we identified two degenerate single base substitutions (1197T--&gt;C, Thr--&gt;Thr and 976A--&gt;C, Arg--&gt;Arg) in one random and one asthmatic sample respectively.	Arginine	151-154	cholinergic receptor muscarinic 2	Homo sapiens	11-35
11278295-5	2001	The inhibition of the pig skeletal muscle RYR1 by dantrolene (10 microm) was associated with a 3-fold increase in the K(d) of [(3)H]ryanodine binding to sarcoplasmic reticulum (SR) vesicles such that dantrolene effectively reversed the 3-fold decrease in the K(d) for [(3)H]ryanodine binding resulting from the malignant hyperthermia RYR1 Arg(615) --&gt; Cys mutation.	Arginine	339-342	ryanodine receptor 1	Sus scrofa	42-46
8806750-7	1996	Protoporphyrin IX inhibits the arginine-independent NADPH oxidase activity of nNOS with an IC50 value of 1 microM but has no effect on cytochrome c reductase activity at concentrations as high as 30 microM.	Arginine	31-39	nitric oxide synthase 1, neuronal	Mus musculus	78-82
11152687-6	2001	Unlike reported studies of other Fc Rgamma partners, these studies reveal that both the GPVI transmembrane arginine and intracellular C-tail are necessary for coupling to Fc Rgamma and for signal transduction.	Arginine	107-115	glycoprotein 6 (platelet)	Mus musculus	88-92
8886430-10	1996	The ability of TRIM to inhibit mouse cerebellar nNOS activity in vitro was influenced by the concentration of L-arginine (0.12-10.0 microM) in the incubation medium.	Arginine	110-120	nitric oxide synthase 1, neuronal	Mus musculus	48-52
8946107-0	1996	X-linked exudative vitreoretinopathy caused by an arginine to leucine substitution (R121L) in the Norrie disease protein.	Arginine	50-58	norrin cystine knot growth factor NDP	Homo sapiens	98-120
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Arginine	278-281	thimet oligopeptidase 1	Homo sapiens	242-245
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Arginine	308-311	thimet oligopeptidase 1	Homo sapiens	242-245
11096085-10	2001	Additional hIK1/rSK2 chimeras defined the minimal region of hIK1 required to confer complete ATP sensitivity as including amino acids Arg(355)-Ala(413).	Arginine	134-137	potassium calcium-activated channel subfamily N member 4	Homo sapiens	60-64
11096085-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 4	Homo sapiens	63-67
11096085-12	2001	Additionally, substitution of amino acids Arg(355)-Met(368) of hIK1 into the corresponding region of rSK2 resulted in an ATP-dependent activation, which was approximately 50% of that of hIK1.	Arginine	42-45	potassium calcium-activated channel subfamily N member 4	Homo sapiens	186-190
11360114-3	2001	Interestingly, the arginine residue was frequently present at the 3" terminal of BV24S1 segment and was followed by an acidic amino acid residue within the CDR3 region.	Arginine	19-27	CDR3	Homo sapiens	156-160
11067850-1	2001	Nitric-oxide synthases (NOS) catalyze the conversion of l-arginine to NO, which then stimulates many physiological processes.	Arginine	56-66	nitric oxide synthase 1	Homo sapiens	0-22
11327816-12	2001	Arg(491) (in the C-terminal helix close to the GTP #2 binding domain of GDH) is thus considered to be at or near the enzyme"s allosteric ADP site.	Arginine	0-3	glucose dehydrogenase	Bos taurus	72-75
11157057-2	2001	Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.	Arginine	46-54	Pr55(Gag)	Human immunodeficiency virus 1	68-71
11208599-8	2001	Addition of 5 x 10(-3) M L-arginine to the peritubular perfusate overcame the inhibitory effect of L-NNA on high-eta-induced increase in H+ flux.	Arginine	25-35	endothelin receptor type A	Homo sapiens	113-116
11157485-5	2001	Examination of a homology model of the A domains of FVIII predicted (ARG)531 to lie at the interface of the A1 and A2 subunits and stabilize their interaction.	Arginine	69-72	coagulation factor VIII	Homo sapiens	52-57
11175904-1	2001	We have used NMR spectroscopy to determine the solution structure of a complex between an oligonucleotide derived from stem IIB of the Rev responsive element (RRE-IIB) of HIV-1 mRNA and an in vivo selected, high affinity binding Arg-rich peptide.	Arginine	229-232	Rev	Human immunodeficiency virus 1	135-138
11175904-4	2001	A conformational switch of an unpaired uridine base was revealed; this points out into the solvent in the Rev peptide complex, but it is stabilized inside the RNA deep groove by stacking with an Arg side chain in the selected peptide complex.	Arginine	195-198	Rev	Human immunodeficiency virus 1	106-109
11141054-7	2001	These observations indicate that fullerene monomalonate adducts uncouple in the presence of arginine the formation of reactive oxygen intermediates from NO production by nNOS.	Arginine	92-100	nitric oxide synthase 1	Homo sapiens	170-174
11114935-3	2001	We have used site-directed mutagenesis to construct derivatives of UmuD and UmuD" with glycines in place of leucine-101 and arginine-102.	Arginine	124-132	UmuD	Escherichia coli	67-71
11114935-3	2001	We have used site-directed mutagenesis to construct derivatives of UmuD and UmuD" with glycines in place of leucine-101 and arginine-102.	Arginine	124-132	UmuD	Escherichia coli	76-80
11114935-6	2001	Our genetic and biochemical characterizations of these mutant UmuD and UmuD" proteins indicate that while leucine-101 and arginine-102 are critical for the RecA-ssDNA-facilitated self-cleavage of UmuD, they serve only a minimal role in enabling TLS.	Arginine	122-130	UmuD	Escherichia coli	62-66
11114935-6	2001	Our genetic and biochemical characterizations of these mutant UmuD and UmuD" proteins indicate that while leucine-101 and arginine-102 are critical for the RecA-ssDNA-facilitated self-cleavage of UmuD, they serve only a minimal role in enabling TLS.	Arginine	122-130	UmuD	Escherichia coli	71-75
11114935-6	2001	Our genetic and biochemical characterizations of these mutant UmuD and UmuD" proteins indicate that while leucine-101 and arginine-102 are critical for the RecA-ssDNA-facilitated self-cleavage of UmuD, they serve only a minimal role in enabling TLS.	Arginine	122-130	UmuD	Escherichia coli	71-75
11587559-4	2001	The K(d) for arginine is approximately 0.5 microM for the tetrahydrobiopterin replete neuronal and inducible isoforms (nNOS and iNOS), while the endothelial isoform has a slightly higher K(d) (1.5 microM).	Arginine	13-21	nitric oxide synthase 1	Homo sapiens	119-123
11150170-10	2000	In general, the trend is that D-amino acid substitutions of the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10), but not Arg(7), result in an increase in MC3R selectivity over the MC4R and MC5R and only agonist activity is observed.	Arginine	120-123	melanocortin 3 receptor	Homo sapiens	170-174
11150170-11	2000	Thus, the key residues of gamma-MSH identified in this study include the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10) (but not Arg(7)), as important for MC3 selectivity over the MC4 and MC5 subtypes.	Arginine	129-132	melanocortin 3 receptor	Homo sapiens	172-175
11120840-2	2000	A predicted model generated from the nuclear magnetic resonance structure of a related protein, NK lysin, suggested that granulysin contains a four alpha helical bundle motif, with the alpha helices enriched for positively charged amino acids, including arginine and lysine residues.	Arginine	254-262	granulysin	Homo sapiens	121-131
11120840-4	2000	Chemical modification of the arginine, but not the lysine, residues also blocked the antimicrobial activity and interfered with the ability of granulysin to adhere to Escherichia coli and Mycobacterium tuberculosis.	Arginine	29-37	granulysin	Homo sapiens	143-153
11106495-12	2000	Surprisingly, R(6)R(4)R(1)-eglin, in which Arg was substituted for Gly(40) in R(4)R(1)-eglin, exhibited stable, high-affinity complex formation with Kex2 (K(a) of 3.5 x 10(9) M(-)(1)) but temporary inhibition of furin.	Arginine	43-46	furin, paired basic amino acid cleaving enzyme	Homo sapiens	212-217
11006267-2	2000	In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.	Arginine	32-35	C-terminal Src kinase	Homo sapiens	77-98
8709225-10	1996	Site-directed mutagenesis revealed residues 100 to 102 (Phe-Arg-Arg) as the critical p120 contact site; nonconservative substitution in any of the three positions abolished p120 binding.	Arginine	60-63	catenin delta 1	Homo sapiens	85-89
11006267-2	2000	In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.	Arginine	32-35	C-terminal Src kinase	Homo sapiens	100-103
8709225-10	1996	Site-directed mutagenesis revealed residues 100 to 102 (Phe-Arg-Arg) as the critical p120 contact site; nonconservative substitution in any of the three positions abolished p120 binding.	Arginine	60-63	catenin delta 1	Homo sapiens	173-177
11006267-2	2000	In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.	Arginine	37-40	C-terminal Src kinase	Homo sapiens	77-98
11006267-2	2000	In this study, the role of this Arg (Arg-318) in the protein-tyrosine kinase C-terminal Src kinase (Csk) was investigated.	Arginine	37-40	C-terminal Src kinase	Homo sapiens	100-103
11006267-4	2000	The k(cat) value for poly(Glu,Tyr) phosphorylation by the Csk double mutant A316R,R318A is 100-fold greater than the k(cat) value for the single R318A mutant, suggesting that an Arg positioned at the alternative location fulfills a similar function as in wild type.	Arginine	178-181	C-terminal Src kinase	Homo sapiens	58-61
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Arginine	150-153	major histocompatibility complex, class II, DP beta 1	Homo sapiens	25-29
8865189-7	1996	NG-Nitro-L-arginine methyl ester and 7-nitro indazole reduced cyclic GMP levels in the cerebral cortex/hippocampus and cerebellum, and the suppressive effect of NG-nitro-L-arginine methyl ester on cyclic GMP levels in the cerebral cortex/hippocampus was reversed by co-treatment with L-arginine.	Arginine	9-19	5'-nucleotidase, cytosolic II	Mus musculus	69-72
8865189-7	1996	NG-Nitro-L-arginine methyl ester and 7-nitro indazole reduced cyclic GMP levels in the cerebral cortex/hippocampus and cerebellum, and the suppressive effect of NG-nitro-L-arginine methyl ester on cyclic GMP levels in the cerebral cortex/hippocampus was reversed by co-treatment with L-arginine.	Arginine	9-19	5'-nucleotidase, cytosolic II	Mus musculus	204-207
8718865-6	1996	The ability of bleomycin hydrolase to oligomerize was neither affected by the subtle cysteine/serine mutation nor affected by cysteine/arginine or histidine/glycine mutations.	Arginine	135-143	bleomycin hydrolase	Saccharomyces cerevisiae S288C	15-34
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Arginine	150-153	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
8702554-6	1996	The most conserved residues within this region are RGFGIGS beginning at Arg-101 in the human SSAT.	Arginine	72-75	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	93-97
11169249-2	2000	Both alleles differ from DPB1*0402 by a single nucleotide: DPB1*8201 has a difference at position 359 (codon 91) leading to an amino acid change from arg to his, making this position a new polymorphic site; DPB1*8301 has a difference at position 280 (codon 65) changing the amino acid from ile to phe.	Arginine	150-153	major histocompatibility complex, class II, DP beta 1	Homo sapiens	59-63
8702554-10	1996	Our data are consistent with the hypothesis that Arg-101 and the proximal glycine loop are necessary for the activity of human SSAT.	Arginine	49-52	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	127-131
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Arginine	51-59	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	248-256	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
8840009-7	1996	Treatment of PSD fractions with L-arginine, a substrate for endogenous NOS, caused a 3-fold increase in C/C-DP activity.	Arginine	32-42	cut-like homeobox 1	Rattus norvegicus	106-110
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	248-256	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11062153-9	2000	Cloning and sequencing of SULT1A1 cDNA from MCF-7 cells revealed that mRNAs encoding two previously identified allelic variants, SULT1A1*1 ((213)Arg) and SULT1A1*2 ((213)His), were expressed in these cells.	Arginine	145-148	sulfotransferase family 1A member 1	Homo sapiens	26-33
8864557-11	1996	The release of CGRP evoked by ETX was enhanced by L-arginine by 43% and inhibited by N omega-nitro-L-arginine (L-NOARG) and methylene blue by 37% and 38%, respectively.	Arginine	50-60	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
8707864-1	1996	A soluble form of the human transferrin receptor (TfR) resulting from proteolytic cleavage at Arg 100 has been measured in human blood.	Arginine	94-97	transferrin receptor	Homo sapiens	28-48
11062153-9	2000	Cloning and sequencing of SULT1A1 cDNA from MCF-7 cells revealed that mRNAs encoding two previously identified allelic variants, SULT1A1*1 ((213)Arg) and SULT1A1*2 ((213)His), were expressed in these cells.	Arginine	145-148	sulfotransferase family 1A member 1	Homo sapiens	129-136
11062153-9	2000	Cloning and sequencing of SULT1A1 cDNA from MCF-7 cells revealed that mRNAs encoding two previously identified allelic variants, SULT1A1*1 ((213)Arg) and SULT1A1*2 ((213)His), were expressed in these cells.	Arginine	145-148	sulfotransferase family 1A member 1	Homo sapiens	129-136
11020349-1	2000	Protein transduction domains (PTDs), such as the third helix of the Drosophila Antennapedia homeobox gene (Antp) and the HIV TAT PTD, possess a characteristic positive charge on the basis of their enrichment for arginine and lysine residues.	Arginine	212-220	Antennapedia	Drosophila melanogaster	107-111
8707864-1	1996	A soluble form of the human transferrin receptor (TfR) resulting from proteolytic cleavage at Arg 100 has been measured in human blood.	Arginine	94-97	transferrin receptor	Homo sapiens	50-53
11001950-6	2000	One of the SR-BI mutants, which has a double substitution of arginines for glutamines at positions 402 and 418 (Q402R/Q418R), exhibited a high level of LDL binding and lipid uptake from LDL, but lost most of the corresponding HDL receptor activity.	Arginine	61-70	scavenger receptor class B, member 1	Mus musculus	11-16
8692893-1	1996	Besides synthesizing nitric oxide (NO), purified neuronal NO synthase (nNOS) can produce superoxide (.O2-) at lower L-Arg concentrations.	Arginine	116-121	nitric oxide synthase 1	Homo sapiens	71-75
10856302-2	2000	The structural features of TIP39, determined in the presence of a zwitterionic lipid to mimic the membrane environment of the G-protein-coupled PTH2 receptor, consist of two alpha-helices, Ala(5)-Arg(21) and Leu(26)-Val(35).	Arginine	196-199	parathyroid hormone 2	Homo sapiens	27-32
8662780-2	1996	The interaction between the Fv fragment and the RP135 peptide derived from the V3 loop of gp120 from HIV-1IIIB was studied by varying the salt concentration and by mutating arginine residues in the peptide.	Arginine	173-181	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	90-95
10933889-3	2000	We have previously demonstrated the importance for RA binding and RA-dependent transactivation of Arg(276) in RARalpha and Arg(278) in RARgamma; however, in RARbeta Arg(269) functions in conjunction with Lys(220).	Arginine	98-101	retinoic acid receptor gamma	Homo sapiens	135-143
8648541-3	1996	The His(H)-Arg(R) polymorphism at amino acid 131 of the Fc gamma RIIA receptor alters binding affinity for human IgG2 and influences infection with encapsulated organisms in children without sickle cell disease.	Arginine	11-14	Fc gamma receptor IIa	Homo sapiens	56-69
10933889-3	2000	We have previously demonstrated the importance for RA binding and RA-dependent transactivation of Arg(276) in RARalpha and Arg(278) in RARgamma; however, in RARbeta Arg(269) functions in conjunction with Lys(220).	Arginine	123-126	retinoic acid receptor gamma	Homo sapiens	135-143
10933889-3	2000	We have previously demonstrated the importance for RA binding and RA-dependent transactivation of Arg(276) in RARalpha and Arg(278) in RARgamma; however, in RARbeta Arg(269) functions in conjunction with Lys(220).	Arginine	123-126	retinoic acid receptor gamma	Homo sapiens	135-143
10942429-1	2000	Pfeiffer syndrome is a classic form of craniosynostosis that is caused by a proline--&gt;arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1).	Arginine	89-97	fibroblast growth factor receptor 1	Mus musculus	144-179
8612536-8	1996	Furthermore, L-Arg (1 or 10.0 mM) and the NO donor, sodium nitroprusside (1 or 10.0 mM), stimulated the basal and K(+)-induced in vitro release of LHRH and NPY from the hypothalami of ovarian steroid-primed ovx rats.	Arginine	13-18	gonadotropin releasing hormone 1	Homo sapiens	147-151
10942429-1	2000	Pfeiffer syndrome is a classic form of craniosynostosis that is caused by a proline--&gt;arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1).	Arginine	89-97	fibroblast growth factor receptor 1	Mus musculus	181-186
8633068-3	1996	Site-directed mutagenesis of IRP1 and IRP2 reveals that, although the binding affinities for consensus IREs are indistinguishable, the contributions of arginine residues in the active-site cleft to the binding affinity are different in the two RNA binding sites.	Arginine	152-160	aconitase 1	Homo sapiens	29-33
10903140-0	2000	The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.	Arginine	63-71	linker for activation of T cells family member 2	Homo sapiens	49-53
8786430-2	1996	Tat proteins containing mutations in the Arg-Gly-Asp (RGD) cell adhesion motif or a deletion of the cysteine-rich domain had no effect on neuronal morphology.	Arginine	41-44	tyrosine aminotransferase	Homo sapiens	0-3
11019368-5	2000	In a previous work, we studied the effect of L-arginine, the substrate of nitric oxide synthetase (NOS), on utrophin expression at the muscle membrane.	Arginine	45-55	nitric oxide synthase 1, neuronal	Mus musculus	74-97
8631807-5	1996	Purified recombinant Rt6-2, but not Rt6-1, shows NAD+ glycohydrolase activity, which is inhibited by the arginine analogue agmatine.	Arginine	105-113	ADP-ribosyltransferase 2a	Mus musculus	21-24
11014594-2	2000	Specifically, the remote correlation between the guanidinium nitrogen 15Nepsilon of arginine 71, which serves as the hydrogen donor, and the acceptor carboxylate carbon 13CO2gamma of aspartate 100 in a 12 kDa protein, human FKBP12, is detected via the trans-hydrogen bond 3h JNepsilonCO2gamma coupling by employing a novel HNCO-type experiment, soft CPD-HNCO.	Arginine	84-92	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	224-230
8742569-9	1996	Interestingly, the frequency of DQB1*non-Asp-57 and DQA1*Arg-52 alleles in the Korean adult control population was similar to that in the U.S. white population (DQB1*non-Asp-57: 0.431 vs. 0.475; DQA1*Arg-52: 0.492 vs. 0.463).	Arginine	57-60	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	52-56
10951256-0	2000	A novel arginine-->Serine mutation in EDA1 in a Japanese family with X-linked anhidrotic ectodermal dysplasia.	Arginine	8-16	ectodysplasin A	Homo sapiens	38-42
8745402-3	1996	Catalytic rate measurements on single and double mutants indicate that pK1 is mainly due to the deprotonation of Lys 120 and Lys 134, with only a minor contribution from other surface basic residues, whereas pK2 is due to titration of the invariant Arg 141, likely coupled to deprotonation of the copper-bound water molecule.	Arginine	249-252	prokineticin 1 L homeolog	Xenopus laevis	71-74
8815575-1	1996	Inherited resistance to activated protein C (APC-resistance), caused by a point mutation in the factor V gene leading to replacement of Arg(R)506 with a Gln (Q), and inherited protein S deficiency are associated with functional impairment of the protein C anticoagulant system, yielding lifelong hypercoagulability and increased risk of thrombosis.	Arginine	136-139	APC regulator of WNT signaling pathway	Homo sapiens	45-48
8617202-2	1996	In a yeast two-hybrid screen, the Clk/Sty kinase specifically interacted with RNA binding proteins, particularly members of the serine/arginine-rich (SR) family of splicing factors.	Arginine	135-143	CDC like kinase 1	Homo sapiens	34-37
8617202-3	1996	Clk/Sty itself has an serine/arginine-rich non-catalytic N-terminal region which is important for its association with SR splicing factors.	Arginine	29-37	CDC like kinase 1	Homo sapiens	0-3
8617202-4	1996	In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain).	Arginine	119-127	CDC like kinase 1	Homo sapiens	10-13
8927232-2	1996	HP inhibited n-NOS activity noncompetitively versus L-arginine as a substrate, decreasing the maximal velocity (Ki value for HP = 31 microM).	Arginine	52-62	nitric oxide synthase 1	Homo sapiens	13-18
8522591-2	1995	To evaluate the function and potential disease association of K18, we examined the effects of mutating a highly conserved arginine (arg89) of K18.	Arginine	122-130	keratin 18	Mus musculus	142-145
8616623-2	1995	Rats treated with L-arginine had higher rCBF, determined by hydrogen clearance method, in the ischemic core (7 +/- 1 ml/100 g/min, mean +/- S.E.M.)	Arginine	18-28	CCAAT/enhancer binding protein zeta	Rattus norvegicus	40-44
8616623-5	1995	In another experiment, the effects of L-arginine on rCBF in the subcortical regions and on infarct volume were evaluated.	Arginine	38-48	CCAAT/enhancer binding protein zeta	Rattus norvegicus	52-56
8616623-6	1995	L-arginine, compared with saline, increased rCBF by 8 ml/100 g/min in the ischemic side and reduced infarct volume by 29% at 24 h of ischemia.	Arginine	0-10	CCAAT/enhancer binding protein zeta	Rattus norvegicus	44-48
7592877-2	1995	Furin is a Golgi membrane-associated endoprotease that is involved in cleavage of various precursor proteins predominantly at Arg-X-Lys/Arg-Arg sites.	Arginine	126-129	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7592877-2	1995	Furin is a Golgi membrane-associated endoprotease that is involved in cleavage of various precursor proteins predominantly at Arg-X-Lys/Arg-Arg sites.	Arginine	136-139	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7592877-2	1995	Furin is a Golgi membrane-associated endoprotease that is involved in cleavage of various precursor proteins predominantly at Arg-X-Lys/Arg-Arg sites.	Arginine	136-139	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7592877-3	1995	Furin itself is synthesized as an inactive precursor, which is activated through intramolecular autocatalytic cleavage at an Arg-X-Lys-Arg site.	Arginine	125-128	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7592877-3	1995	Furin itself is synthesized as an inactive precursor, which is activated through intramolecular autocatalytic cleavage at an Arg-X-Lys-Arg site.	Arginine	135-138	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7592877-4	1995	We previously found that human colon carcinoma LoVo cells have a frameshift mutation within the homo B domain of furin and thereby lack processing activity toward Arg-X-Lys/Arg-Arg sites.	Arginine	163-166	furin, paired basic amino acid cleaving enzyme	Homo sapiens	113-118
7592877-4	1995	We previously found that human colon carcinoma LoVo cells have a frameshift mutation within the homo B domain of furin and thereby lack processing activity toward Arg-X-Lys/Arg-Arg sites.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	113-118
7592877-4	1995	We previously found that human colon carcinoma LoVo cells have a frameshift mutation within the homo B domain of furin and thereby lack processing activity toward Arg-X-Lys/Arg-Arg sites.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	113-118
7592877-6	1995	The mutation, a replacement of a conserved Trp residue within the homo B domain with Arg, results in lack of processing activity of the mutant furin.	Arginine	85-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	143-148
8526612-9	1995	The incidence of ventricular fibrillation, malonaldehyde release, and soluble intracellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 were each significantly decreased during reperfusion in the L-arginine group.	Arginine	254-264	E-selectin	Sus scrofa	113-154
8555090-2	1995	A single base polymorphism at position 131 of Fc gamma RIIA changes the native arginine to histidine.	Arginine	79-87	Fc gamma receptor IIa	Homo sapiens	46-59
7585510-4	1995	Transfection of a naturally occurring mutant VHL gene (nucleotide 713 G to A, Arg to Gln) did not lead to growth suppression of these renal carcinoma cells, nor did transfection of the wild-type VHL gene into two non-renal tumor cell lines that expressed the endogenous wild-type VHL gene.	Arginine	78-81	von Hippel-Lindau tumor suppressor	Homo sapiens	45-48
7592688-8	1995	A major phosphorylation target in p21/SIIR was localized to the Arg/Ser-rich region between amino acids 12 and 49.	Arginine	64-67	transcription elongation factor A like 1	Homo sapiens	34-37
7592688-8	1995	A major phosphorylation target in p21/SIIR was localized to the Arg/Ser-rich region between amino acids 12 and 49.	Arginine	64-67	transcription elongation factor A like 1	Homo sapiens	38-42
7548140-8	1995	We conclude that upregulation of arginine transport is part of a pleiotropic response to EGF/TGF alpha, and that this involves PKC and de novo synthesis of polypeptides associated with system y+ transport activity.	Arginine	33-41	transforming growth factor alpha	Homo sapiens	93-102
7554111-0	1995	Osteopontin and beta 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro.	Arginine	109-112	secreted phosphoprotein 1	Rattus norvegicus	0-11
7545787-4	1995	Pharmacological blockade of NO production with arginine analogues such as L-nitroarginine (L-NA) or L-N-arginine methyl ester affects multiple isoforms of nitric oxide synthase (NOS), and so cannot distinguish their physiological roles.	Arginine	47-55	nitric oxide synthase 1, neuronal	Mus musculus	155-176
7673215-13	1995	Of the four amino acids tested at position 142, only arginine resulted in a decrease in cytochrome b reduction through center N. These findings are discussed in terms of the structure and function of the quinol oxidation site and seem to indicate that Trp-142 is not critical to the kinetic interaction of ubiquinol with the reductase, but plays an important role in the electron transfer reactions that intervene between ubiquinol oxidation and cytochrome c1 reduction.	Arginine	53-61	cytochrome b	Saccharomyces cerevisiae S288C	88-100
7665584-6	1995	There are three serines in the sequence of eIF-4E that are three residues away from a tryptic cleavage site (i.e. lysine or arginine).	Arginine	124-132	eukaryotic translation initiation factor 4E	Cricetulus griseus	43-49
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Arginine	79-88	cerebellar degeneration related antigen 1	Mus musculus	107-111
16604161-2	2000	For protonated arginine dimer, a good correlation (R = 0.88) was obtained between the molecular mechanics and EDF1 6-31+G* energies, indicating that mechanics with MMFF is suitable for finding low-energy conformers.	Arginine	15-23	endothelial differentiation related factor 1	Homo sapiens	110-114
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Arginine	79-88	cerebellar degeneration-related 2	Mus musculus	115-119
10818253-8	2000	These data indicate that hCRF(2), like all vertebrate CRF(1) and CRF(2) proteins encodes an arginine residue at the junction between extracellular domain 2 and transmembrane domain 3 and that this amino acid plays a role for the discrimination of some CRF peptide ligands.	Arginine	92-100	corticotropin releasing hormone receptor 1	Homo sapiens	54-60
24394355-6	1995	2) HLA-DQA1 and B1 alleles contribute to susceptibility to IDDM IDDM is strongly associated with the presence of arginine in position 52 of the DQ alpha chain and absence of aspartic acid in position 57 of the DQ beta chain in Caucasians.	Arginine	113-121	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	3-11
7650737-0	1995	The roles of arginine 41 and tyrosine 76 in the coupling of DNA recognition to phosphodiester bond cleavage by DNase I: a study using site-directed mutagenesis.	Arginine	13-21	deoxyribonuclease 1	Bos taurus	111-118
10873836-6	2000	Plasmin achieves this unexpected, large differential activity even though both target sequences possess an arginine residue in the P1 position.	Arginine	107-115	plasminogen	Homo sapiens	0-7
10824120-0	2000	Arginine-based structures are specific inhibitors of cathepsin C.	Arginine	0-8	cathepsin C	Homo sapiens	53-64
7479680-9	1995	Thus, the ratios of the insulin/IAPP responses to arginine were the same regardless of the glucose level, and the insulin and IAPP responses to arginine were highly correlated with each other at all glucose levels.	Arginine	144-152	islet amyloid polypeptide	Homo sapiens	126-130
10824120-9	2000	The arginine-based peptide inhibitors were selective towards cathepsin C among other cysteine proteinases tested.	Arginine	4-12	cathepsin C	Homo sapiens	61-72
7629101-6	1995	In addition, mutation of the highly conserved Arg residues in the critical FLVR sequences of both SH2 domains of full-length p120 reduces binding to tyrosine-phosphorylated p190.	Arginine	46-49	RAS p21 protein activator 1	Homo sapiens	125-129
10809695-0	2000	In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex.	Arginine	43-51	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	148-152
7629101-6	1995	In addition, mutation of the highly conserved Arg residues in the critical FLVR sequences of both SH2 domains of full-length p120 reduces binding to tyrosine-phosphorylated p190.	Arginine	46-49	contactin associated protein 1	Homo sapiens	173-177
10809695-0	2000	In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex.	Arginine	43-51	transcriptional regulator SIN3	Saccharomyces cerevisiae S288C	162-166
7608199-5	1995	AAP3 and AAP5 efficiently transport arginine and lysine and are involved in basic amino acid transport.	Arginine	36-44	amino acid permease 3	Arabidopsis thaliana	0-4
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	123-131	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	60-64
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	247-255	DNA-binding transcriptional regulator UME6	Saccharomyces cerevisiae S288C	60-64
7630732-8	1995	Thirdly, we examine the effects of mutations in the invariant arginine residue of GCN4 (Arg243) that contacts the central base pair(s) of the target sites.	Arginine	62-70	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	82-86
10802096-1	2000	The two peptides isolated from the two different species are identical to [Arg(7)] corazonin, a neuropeptide known to be present in a cockroach and others.	Arginine	75-78	pro-corazonin	Bombyx mori	83-92
10835240-10	2000	As a result, through coordinated additions of PEP, arginine, cysteine, tryptophan, and magnesium, the final concentration of cell-free synthesized CAT increased more than 4-fold compared to a batch reaction.	Arginine	51-59	chloramphenicol acetyltransferase	Escherichia coli	147-150
8846442-7	1995	However, this L-arginine-derived autacoid may have a role in the irritant-induced CGRP release from afferent vasodilator fibres in the skin.	Arginine	14-24	calcitonin-related polypeptide alpha	Rattus norvegicus	82-86
10834426-9	2000	L-Arginine produced a fall in sBP and dBP to baseline values and normalized squatting ratios.	Arginine	0-10	selenium binding protein 1	Homo sapiens	30-33
8948898-5	1995	Among the patients, 92.78 carry DQA1 alleles that have ARG in position 52 of DQa chain, and 78.2% are ASP- in DQ5-57.	Arginine	55-58	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	32-36
10764839-0	2000	A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.	Arginine	115-123	fucosyltransferase 8	Homo sapiens	60-87
7490252-3	1995	To determine whether the sequence of beta-MPP is essential for the enzymatic activity, we individually mutated the histidines and glutamic acid to arginines and glutamine, respectively.	Arginine	147-156	peptidase, mitochondrial processing subunit beta	Rattus norvegicus	37-45
10781087-3	2000	A missense mutation at a conserved arginine residue in the amino-terminal MH1 domain of both Smad2 and Smad4 has been identified in tumors from patients with colorectal and pancreatic cancers, respectively.	Arginine	35-43	SMAD family member 2	Homo sapiens	93-98
7663153-2	1995	By the polymerase chain reaction, the complete gene encoding for E. coli thioredoxin was modified and amplified with the addition at its 5" end of a BamHI cloning site and a triplet coding for an arginine residue instead of the initiator methionine codon, whereas at the 3" end the stop codon was followed by an EcoRI cloning site.	Arginine	196-204	thioredoxin	Bos taurus	73-84
7558930-7	1995	Sequence analysis of cDNA clones identified a seventh allele of TAP2, TAP2*F, which contains an arginine-to-cystine interchange at amino acid position 651.	Arginine	96-104	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	64-68
10781087-3	2000	A missense mutation at a conserved arginine residue in the amino-terminal MH1 domain of both Smad2 and Smad4 has been identified in tumors from patients with colorectal and pancreatic cancers, respectively.	Arginine	35-43	SMAD family member 4	Homo sapiens	103-108
7558930-7	1995	Sequence analysis of cDNA clones identified a seventh allele of TAP2, TAP2*F, which contains an arginine-to-cystine interchange at amino acid position 651.	Arginine	96-104	transporter 2, ATP binding cassette subfamily B member	Homo sapiens	70-74
10754475-22	2000	GHRH+ARG or PD and HEX are strong stimuli of GH secretion which, however, is maximally stimulated by a combination of GHRH and a low dose of HEX.	Arginine	5-8	hematopoietically expressed homeobox	Homo sapiens	141-144
7591479-5	1995	In the largest-scale synthesis carried out, 0.8 g of HPLC-purified indolicidin (&gt; 99% pure) was obtained, representing a 39% overall yield based on C-terminal Arg(Pmc) anchored to PAL-PS-resin.	Arginine	162-165	cathelicidin-4	Bos taurus	67-78
7538140-7	1995	All of the identified antigens, including the human homolog of yeast Prp22 (HRH1), contain a similar structural element characterized by arginine alternating with serine, glutamate, and/or aspartate.	Arginine	137-145	DEAH-box ATP-dependent RNA helicase PRP22	Saccharomyces cerevisiae S288C	69-74
7659439-6	1995	Intrathecal administration of L-arginine, a substrate of nitric oxide synthase (NOS), in conscious mice resulted in allodynia.	Arginine	30-40	nitric oxide synthase 1, neuronal	Mus musculus	57-78
7537092-1	1995	Nitric oxide synthase (NOS) catalyzes the oxidation of L-arginine to citrulline and nitric oxide (.NO).	Arginine	55-65	nitric oxide synthase 1, neuronal	Mus musculus	0-21
21556614-8	1995	Single-strand conformation polymorphism and direct cycle DNA sequencing analyses demonstrated a PIC1 variant (with an AGC to AGA substitution at codon 31 culminating in a serine to arginine replacement) in Mahlavu, PLC/PRF/5, SiHa, A549 and Raji cell lines.	Arginine	181-189	small ubiquitin like modifier 1	Homo sapiens	96-100
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Arginine	11-14	secreted phosphoprotein 1	Mus musculus	75-78
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Arginine	4-7	angiogenin	Homo sapiens	47-50
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Arginine	4-7	angiogenin	Homo sapiens	94-97
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Arginine	73-76	angiogenin	Homo sapiens	47-50
7708754-6	1995	The Arg-Gly-Asp segment of this site in bovine Ang, which is replaced by Arg-Glu-Asn in human Ang, does not have a conformation typical of an integrin recognition site.	Arginine	73-76	angiogenin	Homo sapiens	94-97
7774880-4	1995	Arginine (R) at position 46 and alanine (A) at position 54 were shown to be an agretopic motif bound to I-Ag7 molecules.	Arginine	0-8	I-ag7	Mus musculus	104-109
7532198-5	1995	This arginine residue in a highly conserved region of keratins 1 and 10 is affected by disruptive missense point mutations in many patients with bullous ichthyosiform erythroderma.	Arginine	5-13	keratin 1	Homo sapiens	54-71
8529104-1	1995	BACKGROUND: Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissue perfusion), but also of key aspects of local and systemic inflammatory responses.	Arginine	85-95	nitric oxide synthase 1, neuronal	Mus musculus	99-120
7840180-7	1995	Somatostatin inhibited forskolin, theophylline, and arginine stimulation of glucagon secretion.	Arginine	52-60	somatostatin	Cricetulus griseus	0-12
7528781-3	1995	The maximal activity of NO synthase (NOS) was about 200-fold higher in cell lysates from the tEnd.1 endothelioma cell line than in lysates from nontransformed controls, whereas the affinity for arginine did not differ.	Arginine	194-202	nitric oxide synthase 1, neuronal	Mus musculus	24-35
7542713-7	1995	The Km for arginine was virtually identical for the control and hph-1 NOS when BH4 was present in the reaction buffer.	Arginine	11-19	hyperphenylalaninemia 1	Mus musculus	64-69
7542713-8	1995	In the absence of cofactor, the Km for arginine was 3-fold greater for control and 5-fold greater for hph-1 preparations.	Arginine	39-47	hyperphenylalaninemia 1	Mus musculus	102-107
7829968-0	1995	Ligation of CD23 activates soluble guanylate cyclase in human monocytes via an L-arginine-dependent mechanism.	Arginine	79-89	Fc epsilon receptor II	Homo sapiens	12-16
8643356-1	1995	The Tat and Rev proteins of HIV-1 and the Rex protein of HTLV-I do not interact with their cognate ligands via a particular structural motif but instead specifically recognize RNA molecules by using agglomerations of arginine residues (1).	Arginine	217-225	Rev	Human immunodeficiency virus 1	12-15
7528998-2	1994	CGRP, in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta.	Arginine	149-159	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
9098450-5	1994	When DQA1-DQB1 genotypes were analysed for presence of Arg 52 (DQ alpha) and absence of Asp 57 (DQ beta), genotypes SS/SS were found significantly increased in diabetics.	Arginine	55-58	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	5-9
7535732-3	1994	Recently, we described a leprechaun patient having an Arg for Gly substitution in one allele of the insulin receptor whereas the other allele has the normal sequence.	Arginine	54-57	insulin receptor	Homo sapiens	100-116
7894031-0	1994	Protein C deficiency found in a patient with acute myocardial infarction: a single base mutation 157 Arg (CGA) to stop codon (TGA).	Arginine	101-104	T-box transcription factor 1	Homo sapiens	126-129
7964750-7	1994	We conclude that the STOP protein incorporates arginine by a posttranslational reaction but that only a small fraction of the STOP protein shows acceptor capacity in vitro.	Arginine	47-55	microtubule-associated protein 6	Rattus norvegicus	21-25
7969127-5	1994	Furthermore, expression of Ub carrying a K-63 to arginine 63 substitution in a strain of Saccharomyces cerevisiae that is missing the poly-Ub gene, UBI4, fails to compensate for the stress defects associated with these cells.	Arginine	49-57	ubiquitin	Saccharomyces cerevisiae S288C	27-29
7878073-11	1994	The protective effect of arginine and prazosin in cold-induced hypertension may be related both to their reduction in plasma renin activity and to a reduced responsiveness to angiotensin II, as well as to their abilities to increase the secretion of dopamine.	Arginine	25-33	renin	Rattus norvegicus	125-130
7978053-6	1994	RESULTS: A C-to-T transition was identified at a CpG site in codon 196 resulting in a change from arginine to a stop codon (CGA to TGA).	Arginine	98-106	T-box transcription factor 1	Homo sapiens	131-134
7977783-1	1994	The intervention of the L-arginine-NO pathway in renal vasodilation and renin secretion was studied in an isolated perfused rat kidney model.	Arginine	24-34	renin	Rattus norvegicus	72-77
7949182-8	1994	CD23 ligation during this low-proliferative phase induced a rapid activation of L-arginine-dependent pathway and the intracellular accumulation of cyclic guanosine monophosphate and cyclic adenosine monophosphate (cAMP).	Arginine	80-90	Fc epsilon receptor II	Homo sapiens	0-4
7523698-0	1994	Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev trans activator.	Arginine	28-36	Rev	Human immunodeficiency virus 1	92-95
7523698-6	1994	Importantly, these findings suggest that no single amino acid within the arginine-rich domain of Rev is, by itself, essential for activity and that considerable functional redundancy is therefore likely to exist within this region.	Arginine	73-81	Rev	Human immunodeficiency virus 1	97-100
7523698-8	1994	This observation indicates that features of the arginine-rich region that are additional to those required for RNA binding are important for Rev"s correct accumulation in the nucleus.	Arginine	48-56	Rev	Human immunodeficiency virus 1	141-144
7918650-0	1994	Polymorphism of human transcobalamin II: substitution of proline and/or glutamine residues by arginine.	Arginine	94-102	transcobalamin 2	Homo sapiens	22-39
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	93-96	transcobalamin 2	Homo sapiens	32-37
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	93-96	transcobalamin 2	Homo sapiens	191-196
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	101-104	transcobalamin 2	Homo sapiens	32-37
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	101-104	transcobalamin 2	Homo sapiens	191-196
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	101-104	transcobalamin 2	Homo sapiens	32-37
7918650-3	1994	Nucleotide sequence analysis of TC II cDNA amplified from these cells revealed that residues Arg and Arg, Gln and Arg, and Gln and Pro were present at positions 234 and 259, respectively, in TC II alleles encoding the X, S and M types.	Arginine	101-104	transcobalamin 2	Homo sapiens	191-196
7918650-4	1994	Based on these results, we suggest that differences in the anodic mobilities of the various polymorphic forms of TC II such as the X, S and M types are due to charge difference on the protein caused by the replacement of uncharged residues by arginine at positions 234 and/or 259.	Arginine	243-251	transcobalamin 2	Homo sapiens	113-118
7932740-8	1994	In free histone H1, all the centrally located Arg sites are accessible to clostripain.	Arginine	46-49	H1.0 linker histone	Rattus norvegicus	8-18
10734118-5	2000	Mutation of the Arg(15) and Phe(17) residues caused loss in ligand binding, and utilizing a homology model of FcepsilonRI-alpha based on the solved structure of FcgammaRIIa, it appears likely that this decrease is brought about by collapse of the interface and consequently the IgE-binding site.	Arginine	16-19	Fc epsilon receptor Ia	Homo sapiens	110-127
10734118-5	2000	Mutation of the Arg(15) and Phe(17) residues caused loss in ligand binding, and utilizing a homology model of FcepsilonRI-alpha based on the solved structure of FcgammaRIIa, it appears likely that this decrease is brought about by collapse of the interface and consequently the IgE-binding site.	Arginine	16-19	Fc gamma receptor IIa	Homo sapiens	161-172
10700017-7	2000	Also, KA-induced HSP72 stress response was attenuated by pre-treatment with L-arginine.	Arginine	76-86	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	17-22
7983809-3	1994	In Caucasians, this susceptibility is thought to be determined by DQA1 and DQB1 genes including the presence of arginine at position 52 of the DQ alpha chain and the absence of aspartic acid at position 57 of the DQ beta chain.	Arginine	112-120	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	66-70
8049245-7	1994	Trypsin also cleaved RGL at two sites (Arg-55 and Arg-229) leading to four identifiable fragments (R1, R2, R3 and R4).	Arginine	39-42	ral guanine nucleotide dissociation stimulator like 1	Homo sapiens	21-24
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	atrophin 1	Homo sapiens	104-109
8049245-7	1994	Trypsin also cleaved RGL at two sites (Arg-55 and Arg-229) leading to four identifiable fragments (R1, R2, R3 and R4).	Arginine	50-53	ral guanine nucleotide dissociation stimulator like 1	Homo sapiens	21-24
8049245-8	1994	One cleavage site (Arg-229) was found to be identical in both RGL and HGL.	Arginine	19-22	ral guanine nucleotide dissociation stimulator like 1	Homo sapiens	62-65
10675493-7	2000	Sequencing analysis revealed two types of mutations; i) G to C (GCAG to CCAG) transversion type mutation at intron 1-exon 2 splice junction and ii) another C to T transition type mutation resulting in CGA to TGA changing arginine to a termination codon at p16INK4alpha gene codon 80 and the same mutation will alter codon 94 of p19ARF gene from CCG to CTG (proline to leucine).	Arginine	221-229	T-box transcription factor 1	Homo sapiens	208-211
8048007-12	1994	Pretreatment with L-arginine, but not D-arginine, reverses these effects of CGRP antagonism.	Arginine	18-28	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
10762004-4	2000	SULT1A1*His shows lower enzyme activity and thermostability than SULT1A1*Arg.	Arginine	73-76	sulfotransferase family 1A member 1	Homo sapiens	0-7
10762004-4	2000	SULT1A1*His shows lower enzyme activity and thermostability than SULT1A1*Arg.	Arginine	73-76	sulfotransferase family 1A member 1	Homo sapiens	65-72
10762004-15	2000	The results demonstrate a strong association of the alleles producing the more active enzyme variants (SULT1A1*Arg and SULT1A2*Asn) and of those encoding the less active variants (SULT1A1*His and SULT1A2*Thr).	Arginine	111-114	sulfotransferase family 1A member 1	Homo sapiens	103-110
15299414-4	1994	In vitro, Tat binds through its basic domain (two Lys and six Arg in nine residues) to a three-nucleotide bulge of a stem-loop RNA structure called TAR.	Arginine	62-65	tyrosine aminotransferase	Homo sapiens	10-13
10762004-15	2000	The results demonstrate a strong association of the alleles producing the more active enzyme variants (SULT1A1*Arg and SULT1A2*Asn) and of those encoding the less active variants (SULT1A1*His and SULT1A2*Thr).	Arginine	111-114	sulfotransferase family 1A member 1	Homo sapiens	180-187
10681426-1	2000	We determined the structure of the photolytic intermediate of a sperm whale myoglobin (Mb) mutant called Mb-YQR [Leu-(B10)--&gt;Tyr; His(E7)--&gt;Gln; Thr(E10)--&gt;Arg] to 1.4-A resolution by ultra-low temperature (20 K) x-ray diffraction.	Arginine	165-168	myoglobin	Physeter catodon	76-85
8002038-3	1994	The results show that those DQB1 alleles, which carry non-aspartic acid at position 57, in conjunction with DQA1 alleles carrying arginine at position 52, are strongly associated with susceptibility to type 1 diabetes.	Arginine	130-138	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	108-112
10681501-8	2000	The NADPH oxidase activity of nNOS measured in the absence of L-arginine was inhibited by the peptide with an IC(50) of 3.7 +/- 0.6 microM, but the cytochrome c reductase activity of the enzyme was much less susceptible to inhibition (IC(50) &gt;0.1 mM).	Arginine	62-72	nitric oxide synthase 1	Homo sapiens	30-34
7519023-3	1994	The Q/R site is edited &gt; 95% to the arginine codon in GluR2(Q607) mRNA, and &lt; 5% in GluR6(Q621) mRNA.	Arginine	39-47	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	57-62
10681508-0	2000	TA1/LAT-1/CD98 light chain and system L activity, but not 4F2/CD98 heavy chain, respond to arginine availability in rat hepatic cells.	Arginine	91-99	solute carrier family 7 member 5	Rattus norvegicus	0-3
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	90-98	solute carrier family 7 member 5	Rattus norvegicus	36-39
8206990-7	1994	The residues Phe353-Arg354-Ser355 (P2-P1-P1") constitute part of the reactive site loop of PCI with the Arg-Ser peptide bond being cleaved by the proteinase.	Arginine	20-23	endogenous retrovirus group K member 18	Homo sapiens	146-156
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
8086372-8	1994	Arginine (R) occurred in the CDR2 or CDR3 of VH chains in all pathogens; R was absent in the CDRs of VH chains of non-pathogens.	Arginine	0-8	cerebellar degeneration-related 2	Mus musculus	29-33
8086372-8	1994	Arginine (R) occurred in the CDR2 or CDR3 of VH chains in all pathogens; R was absent in the CDRs of VH chains of non-pathogens.	Arginine	10-11	cerebellar degeneration-related 2	Mus musculus	29-33
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
10681508-6	2000	We found 1) increased expression of TA1 in response to amino acid depletion, specific for arginine but not glutamine; 2) loss of TA1 response to arginine in gamma-glutamyl transpeptidase-positive transformed and tumorigenic cells; 3) no appreciable response of 4F2/CD98 heavy chain to arginine levels; and 4) correlation of system L amino acid transport activity in response to arginine with changes in TA1/LAT-1 mRNA but not total immunoreacting protein.	Arginine	145-153	solute carrier family 7 member 5	Rattus norvegicus	129-132
10713728-10	2000	In addition, a number of catabolic enzymes are detected: arginase 1 (which degrades arginine), sulfite oxidase (which degrades sulfur amino acids), and epoxide hydrolase.	Arginine	84-92	arginase 1	Homo sapiens	57-67
10675363-4	2000	Because the single nucleotide polymorphism in FcgammaRIIA - which encodes histidine or arginine at position 131 - strongly influences IgG2 binding, we determined this polymorphism"s effect on CRP binding.	Arginine	87-95	Fc gamma receptor IIa	Homo sapiens	46-57
7527219-0	1994	Immunoreactivity between a monoclonal lupus autoantibody and the arginine/aspartic acid repeats within the U1-snRNP 70K autoantigen is conformationally restricted.	Arginine	65-73	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	110-115
7527219-1	1994	Immunoreactivity of the arginine/aspartic acid (RD) repeats of the 70K protein of U1 small nuclear ribonucleoprotein (snRNP) was determined to be conformationally dependent.	Arginine	24-32	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Mus musculus	118-123
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	146-149	furin (paired basic amino acid cleaving enzyme)	Mus musculus	192-197
10640718-0	2000	Localized expression of the Drosophila gene Dxl6, a novel member of the serine/arginine rich (SR) family of splicing factors.	Arginine	79-87	x16 splicing factor	Drosophila melanogaster	44-48
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	146-149	furin (paired basic amino acid cleaving enzyme)	Mus musculus	192-197
8117273-1	1994	Hepatocyte growth factor (HGF) is a heterodimer protein, derived from an inactive single-chain precursor (pro-HGF) by the proteolytic cleavage at Arg-Val site.	Arginine	146-149	hepatocyte growth factor	Homo sapiens	0-24
8117273-1	1994	Hepatocyte growth factor (HGF) is a heterodimer protein, derived from an inactive single-chain precursor (pro-HGF) by the proteolytic cleavage at Arg-Val site.	Arginine	146-149	hepatocyte growth factor	Homo sapiens	26-29
8117273-1	1994	Hepatocyte growth factor (HGF) is a heterodimer protein, derived from an inactive single-chain precursor (pro-HGF) by the proteolytic cleavage at Arg-Val site.	Arginine	146-149	hepatocyte growth factor	Homo sapiens	110-113
10882080-4	2000	Its helix III contains an arginine-rich motif (ARM), similar to the RNA-binding domain of the HIV-1 protein REV, needed for both RNA and DNA recognition.	Arginine	26-34	Rev	Human immunodeficiency virus 1	108-111
8117273-2	1994	Using a fluorogenic substrate Ac-Lys-Thr-Lys-Gln-Leu-Arg-MCA corresponding to the sequence around the cleavage site of pro-HGF, HGF-converting enzyme was purified from fetal bovine serum.	Arginine	53-56	hepatocyte growth factor	Homo sapiens	128-131
10737978-7	2000	One patient (P2) had a PAX6 protein with de novo in-frame deletion of alanine, arginine, and proline at codon positions 37, 38, and 39.	Arginine	79-87	paired box 6	Homo sapiens	23-27
24190739-5	1994	Aldose reductase inhibitors decrease the concentration of methylglyoxal in experimental diabetic rats to normal levels, aminoguanidine and L-arginine scavenge methylglyoxal; these effects may be involved in their prospective preventive therapy of diabetic complications.	Arginine	139-149	aldo-keto reductase family 1 member B1	Rattus norvegicus	0-16
10651941-2	2000	This polymorphism encodes a nonconservative Gly --&gt; Arg substitution in amino acid 219 in the extracellular, CD40 binding domain of the molecule.	Arginine	55-58	CD40 molecule	Homo sapiens	112-116
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Arginine	42-50	zinc fingers and homeoboxes 2	Homo sapiens	160-163
10678543-0	2000	Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans.	Arginine	103-113	angiotensin II receptor type 1	Homo sapiens	41-44
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Arginine	60-63	RNA polymerase II, I and III subunit E	Homo sapiens	0-4
8307172-5	1994	Furin was specifically inhibited by alpha 1-antitrypsin Pittsburgh (358 Met--&gt;Arg), (K1/2 = 3 microM) but not by 50 microM normal antitrypsin M or by antithrombin, however, antithrombin/heparin was a good inhibitor (K1/2 = 9 microM).	Arginine	81-84	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7508380-1	1994	Furin is a membrane-associated endoprotease that efficiently cleaves precursor proteins on the C-terminal side of the consensus sequence, Arg-X-Lys/Arg-Arg1, and has been proposed to catalyze these reactions in both exocytic and endocytic compartments.	Arginine	138-141	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Arginine	60-63	RNA polymerase II, I and III subunit E	Homo sapiens	112-117
10593939-2	1999	By using the C-terminal arginine-rich region of Arabidopsis U1-70K protein in the yeast two-hybrid system, we have identified an SC35-like (SR33) and a novel plant serine/arginine-rich (SR) protein (SR45) that interact with the plant U1-70K.	Arginine	24-32	SC35-like splicing factor 33	Arabidopsis thaliana	140-144
7508380-1	1994	Furin is a membrane-associated endoprotease that efficiently cleaves precursor proteins on the C-terminal side of the consensus sequence, Arg-X-Lys/Arg-Arg1, and has been proposed to catalyze these reactions in both exocytic and endocytic compartments.	Arginine	148-151	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7508380-1	1994	Furin is a membrane-associated endoprotease that efficiently cleaves precursor proteins on the C-terminal side of the consensus sequence, Arg-X-Lys/Arg-Arg1, and has been proposed to catalyze these reactions in both exocytic and endocytic compartments.	Arginine	148-151	arginase 1	Homo sapiens	152-156
10593939-4	1999	However, both plant SR proteins are rich in proline, and SR45, unlike most animal SR proteins, has two distinct arginine/serine-rich domains separated by an RNA recognition motif.	Arginine	112-120	arginine/serine-rich 45	Arabidopsis thaliana	57-61
8821708-5	1994	We found the inhibition of ADP-ribosylation of MBP by hydroxylamine and L-arginine indicating that this modification was likely to be mediated by arginine residues.	Arginine	72-82	myelin basic protein	Gallus gallus	47-50
10593939-9	1999	These and our previous results suggest that the plant U1-70K interacts with at least four distinct members of the SR family including SR45 with its two arginine/serine-rich domains, and the interaction between the SR proteins and AFC2 is modulated by phosphorylation.	Arginine	152-160	arginine/serine-rich 45	Arabidopsis thaliana	134-138
8821708-5	1994	We found the inhibition of ADP-ribosylation of MBP by hydroxylamine and L-arginine indicating that this modification was likely to be mediated by arginine residues.	Arginine	74-82	myelin basic protein	Gallus gallus	47-50
10593949-0	1999	Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.	Arginine	150-158	WW domain binding protein 11	Homo sapiens	47-52
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Arginine	50-58	tyrosine aminotransferase	Homo sapiens	127-130
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Arginine	4-12	transforming growth factor alpha	Homo sapiens	132-141
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Arginine	50-58	E1A binding protein p300	Homo sapiens	135-139
10607594-7	1999	Furthermore, mutation of these lysine residues to arginine markedly decreased the synergistic activation of he HIV promoter by Tat and p300 or by Tat and cyclin T1.	Arginine	50-58	tyrosine aminotransferase	Homo sapiens	146-149
10589532-2	1999	The calcium conductance of the AMPA receptor is regulated by the GluR2 subunit that is edited at the glutamine/arginine residue site in the subunit assembly.	Arginine	111-119	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	65-70
8035648-3	1994	The purpose of this investigation was to determine if purified homogeneous rat kidney alpha- and beta-L-arginine : glycine amidinotransferase (transamidinase) would catalyze the synthesis of certain neuroactive guanidino compounds, and if so, to determine if any catalytic specificity existed between the two forms of the enzymes.	Arginine	104-112	glycine amidinotransferase	Rattus norvegicus	143-157
7504188-7	1994	The human hprt gene has MeCpG sites contained within arginine codons for which mutations have been recovered on both strands.	Arginine	53-61	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	10-14
10600405-5	1999	We show that in adult normal and mdx mice (an animal model of Duchenne myopathy) treated with l-arginine, the substrate of nitric oxide synthase (NOS), a pool of utrophin localized at the membrane appeared and increased, respectively.	Arginine	94-104	nitric oxide synthase 1, neuronal	Mus musculus	123-144
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Arginine	66-69	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	181-186
7504269-0	1993	Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence.	Arginine	128-131	insulin-like growth factor-binding protein 1	Cricetulus griseus	0-44
10617920-4	1999	RESULTS: We identified the missense point mutation in exon 21 of the RB1 gene converting a Cys--&gt;Arg (codon 712) in one family with a low penetrant phenotype.	Arginine	100-103	RB transcriptional corepressor 1	Homo sapiens	69-72
8225887-20	1993	L-arginine pretreatment reduced the increase in serum creatinine induced by L-NAME+ioxaglate (68 + 17 mumol/L vs. 175 + 59 mumol/L for L-NAME+ioxaglate; P &lt; .05) and urinary NAG excretion.	Arginine	0-10	O-GlcNAcase	Rattus norvegicus	177-180
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	95-98	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	13-17
8143212-7	1993	The data showed that the 2% of total energy supplied by arginine was found to significantly enhance the T lymphocyte response to PHA, CD4 phenotype expression, CD4/CD8 ratio, IL-2 production and IL-2 receptor expression, as compared with the control group.	Arginine	56-64	interleukin 2 receptor subunit beta	Homo sapiens	195-208
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	103-106	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	13-17
8344522-3	1993	The dnaK coding sequence displays extreme codon bias and shows a strong preference for CGY and GGY, for Arg and Gly codons, respectively.	Arginine	104-107	dnaK	Streptomyces coelicolor A3(2)	4-8
10545951-5	1999	The first, a missense mutation at Arg 111 in the DNA-binding domain, abolishes E-box binding activity of NEUROD1.	Arginine	34-37	neurogenic differentiation 1	Mus musculus	105-112
8394989-9	1993	Within this region of alpha s, Arg-42 is just amino-terminal to the G-1 sequence comprising part of the GDP/GTP binding pocket.	Arginine	31-34	mitochondrial ribosome associated GTPase 1	Homo sapiens	108-111
10510312-7	1999	Reciprocal experiments have identified two arginine residues at positions 39 and 40 that are essential for AKAP79(31-52) peptide inhibition of PKCbetaII.	Arginine	43-51	A-kinase anchoring protein 5	Rattus norvegicus	107-113
8334698-3	1993	Remarkably, Tra, Tra2, and members of the serine/arginine-rich (SR) family of general splicing factors are sufficient to commit dsx pre-mRNA to female-specific splicing, and individual SR proteins differ significantly in their ability to participate in commitment complex formation.	Arginine	49-57	doublesex	Drosophila melanogaster	128-131
8514037-5	1993	RESULTS: The CN II patients were found to be homozygous for a nucleotide shift in the unique region of B-UGT1, changing a arginine into a tryptophan, and also for a nucleotide shift in the unique region of B-UGT2, changing a leucine into a valine.	Arginine	122-130	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-109
10516295-2	1999	RNA editing of the codon that encodes the glutamine/arginine (Q/R) site in the second membrane domain (MD2) of glutamate receptor 5 (GluR5) and GluR6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single-channel conductances.	Arginine	52-60	glutamate receptor, ionotropic, kainate 1	Mus musculus	111-131
10516295-2	1999	RNA editing of the codon that encodes the glutamine/arginine (Q/R) site in the second membrane domain (MD2) of glutamate receptor 5 (GluR5) and GluR6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single-channel conductances.	Arginine	52-60	glutamate receptor, ionotropic, kainate 1	Mus musculus	133-138
8503515-5	1993	The vasoconstriction induced by low-dose ET-3 with L-NMMA was suppressed by the additional superfusion of 200 microM L-arginine.	Arginine	117-127	endothelin 3	Rattus norvegicus	41-45
10516295-5	1999	GluR5(RloxP/RloxP) mice encode an arginine at the Q/R site of the GluR5 subunit, whereas GluR5(wt(loxP)/wt(loxP)) mice encode a glutamine at this site, similar to wild-type mice.	Arginine	34-42	glutamate receptor, ionotropic, kainate 1	Mus musculus	0-5
10516295-5	1999	GluR5(RloxP/RloxP) mice encode an arginine at the Q/R site of the GluR5 subunit, whereas GluR5(wt(loxP)/wt(loxP)) mice encode a glutamine at this site, similar to wild-type mice.	Arginine	34-42	glutamate receptor, ionotropic, kainate 1	Mus musculus	66-71
10516295-5	1999	GluR5(RloxP/RloxP) mice encode an arginine at the Q/R site of the GluR5 subunit, whereas GluR5(wt(loxP)/wt(loxP)) mice encode a glutamine at this site, similar to wild-type mice.	Arginine	34-42	glutamate receptor, ionotropic, kainate 1	Mus musculus	66-71
8101181-11	1993	Reduction of GRF resulted in a failure to restore GH response to arginine with pre-treatment of antiserum against somatostatin.	Arginine	65-73	growth hormone releasing hormone	Rattus norvegicus	13-16
8101181-12	1993	Reduction of both GRF and somatostatin caused blunted spontaneous GH secretion and normal GH response to arginine and clonidine.	Arginine	105-113	growth hormone releasing hormone	Rattus norvegicus	18-21
10512763-1	1999	The phenolic side chain of Tyr(4) present in Ang II is proposed to interact with the side chain of Arg 167 of the AT1 receptor.	Arginine	99-102	angiogenin	Homo sapiens	45-48
10529174-8	1999	The sequence analysis of the four mutant mna6 alleles revealed that Leu(109) --&gt; Phe, Arg(111) --&gt; Lys, Pro(424) --&gt; Leu, or Pro(438) --&gt; Leu amino acid substitution in Mna6p causes temperature-dependent loss of the 15S rRNA.	Arginine	89-92	mitochondrial 37S ribosomal protein NAM9	Saccharomyces cerevisiae S288C	41-45
8391452-0	1993	Increase of nitric oxide by L-arginine potentiates beta-endorphin- but not mu-, delta- or kappa-opioid agonist-induced antinociception in the mouse.	Arginine	28-38	pro-opiomelanocortin-alpha	Mus musculus	51-65
8391452-9	1993	administered beta-endorphin-induced inhibition of the tail-flick response, indicating that the potentiating effect of L-arginine on beta-endorphin-induced antinociception is located at the supraspinal sites but not at the spinal sites.	Arginine	118-128	pro-opiomelanocortin-alpha	Mus musculus	13-27
8391452-9	1993	administered beta-endorphin-induced inhibition of the tail-flick response, indicating that the potentiating effect of L-arginine on beta-endorphin-induced antinociception is located at the supraspinal sites but not at the spinal sites.	Arginine	118-128	pro-opiomelanocortin-alpha	Mus musculus	132-146
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Arginine	140-143	furin, paired basic amino acid cleaving enzyme	Homo sapiens	249-254
8476297-2	1993	However, the removal of the (Glu-Ala)2 peptide from the MF alpha 1 spacer region (Lys-Arg-Glu-Ala-Glu-Ala) yielded decreased levels of extracellular alpha-amylase.	Arginine	86-89	Mf(Alpha)1p	Saccharomyces cerevisiae S288C	56-66
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Arginine	152-155	furin, paired basic amino acid cleaving enzyme	Homo sapiens	249-254
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	119-122	zona pellucida glycoprotein 2	Mus musculus	68-72
7682679-2	1993	The enzyme catalyzing the generation of NO and citrulline from L-arginine, nitric oxide synthase (NOS), was found to be identical with neuronal nicotinamide-adenine dinucleotide hydrogen phosphate (NADPH)-diaphorase.	Arginine	63-73	nitric oxide synthase, inducible	Cavia porcellus	75-96
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 2	Mus musculus	68-72
8356923-4	1993	PAs specifically hydrolyse a single arginine-valine bond in plasminogen, an abundant and widely distributed plasma zymogen, to form the broad spectrum serine protease, plasmin.	Arginine	36-44	plasminogen	Homo sapiens	60-67
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 2	Mus musculus	68-72
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 2	Mus musculus	68-72
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 2	Mus musculus	68-72
10493795-8	1999	However, for both mZP2 and mZP3, Arg residues were released by carboxypeptidase B, consistent with processing at the consensus furin cleavage site.	Arginine	33-36	zona pellucida glycoprotein 2	Mus musculus	18-22
1485950-2	1992	Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1.	Arginine	156-164	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	187-191
10493795-8	1999	However, for both mZP2 and mZP3, Arg residues were released by carboxypeptidase B, consistent with processing at the consensus furin cleavage site.	Arginine	33-36	carboxypeptidase B1 (tissue)	Mus musculus	63-81
10480877-5	1999	L-Arginine alone inhibits the generation of superoxide by nNOS but not by C331A-nNOS mutant that has a low affinity for L-arginine.	Arginine	0-10	nitric oxide synthase 1	Homo sapiens	58-62
10480877-6	1999	A greater decrease in superoxide yields is observed when nNOS is preincubated with L-arginine.	Arginine	83-93	nitric oxide synthase 1	Homo sapiens	57-61
10425211-4	1999	On one of the four chromosomes analyzed, we detected an Arg169Gln missense mutation that affects an arginine residue absolutely conserved in the entire transporter superfamily to which OCTN2 belongs.	Arginine	100-108	solute carrier family 22 member 5	Homo sapiens	185-190
1359907-0	1992	An active-site mutation (Gly633--&gt;Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.	Arginine	37-40	dipeptidylpeptidase 4	Rattus norvegicus	45-68
1359907-3	1992	Cloning and sequencing of DPPIV cDNAs revealed a G to A transition at nucleotide 1897 in the cDNA sequence of 344/CRJ, which leads to substitution of Gly633--&gt;Arg in the active-site sequence Gly629-Trp-Ser-Tyr-Gly633 determined for the wild-type DPPIV [Ogata, S., Misumi, Y., Takami, N., Oda, K., &amp; Ikehara, Y.	Arginine	162-165	dipeptidylpeptidase 4	Rattus norvegicus	26-31
1359907-3	1992	Cloning and sequencing of DPPIV cDNAs revealed a G to A transition at nucleotide 1897 in the cDNA sequence of 344/CRJ, which leads to substitution of Gly633--&gt;Arg in the active-site sequence Gly629-Trp-Ser-Tyr-Gly633 determined for the wild-type DPPIV [Ogata, S., Misumi, Y., Takami, N., Oda, K., &amp; Ikehara, Y.	Arginine	162-165	dipeptidylpeptidase 4	Rattus norvegicus	249-254
10414965-5	1999	Substitution of these four amino acids-glycine 171, lysine 173, glutamate 179, and arginine 180-into the beta2 subunit was sufficient to enable the beta2 subunit to homo-oligomerize.	Arginine	83-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-110
1359907-7	1992	Site-directed mutagenesis of the wild-type and mutant cDNAs and their transfection/expression in COS-1 cells confirmed that the single substitution of Gly633--&gt;Arg is sufficient to cause the rapid intracellular degradation of DPPIV.	Arginine	163-166	dipeptidylpeptidase 4	Rattus norvegicus	229-234
1479292-9	1992	A nonsense mutation (Arg 19 Term) in the gene encoding apolipoprotein C-II (apoC-II), the cofactor of LPL, was found to underlie chylomicronemia in the sixth patient who had normal LPL but was apoC-II-deficient.	Arginine	21-24	apolipoprotein C2	Homo sapiens	55-74
1479292-9	1992	A nonsense mutation (Arg 19 Term) in the gene encoding apolipoprotein C-II (apoC-II), the cofactor of LPL, was found to underlie chylomicronemia in the sixth patient who had normal LPL but was apoC-II-deficient.	Arginine	21-24	apolipoprotein C2	Homo sapiens	76-83
1479292-9	1992	A nonsense mutation (Arg 19 Term) in the gene encoding apolipoprotein C-II (apoC-II), the cofactor of LPL, was found to underlie chylomicronemia in the sixth patient who had normal LPL but was apoC-II-deficient.	Arginine	21-24	apolipoprotein C2	Homo sapiens	193-200
10414965-5	1999	Substitution of these four amino acids-glycine 171, lysine 173, glutamate 179, and arginine 180-into the beta2 subunit was sufficient to enable the beta2 subunit to homo-oligomerize.	Arginine	83-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
10477183-11	1999	OP-Tc preference for amino acids in the P2 position was (Gly,Lys,Arg) &gt; Phe &gt; Leu &gt; Pro.	Arginine	65-68	opticin	Bos taurus	0-5
1400325-4	1992	Cytoskeletal association and platelet aggregation were inhibited by the peptide Arg-Gly-Asp-Ser (RGDS) (but not by Arg-Gly-Glu-Ser (RGES)), by 10E5 antibody against glycoprotein (Gp) IIb/IIIa, and by EGTA.	Arginine	80-83	ral guanine nucleotide dissociation stimulator	Homo sapiens	97-101
10400676-6	1999	From this epitope library, a receptor-binding variant of IL-5 was detected, (SLRGG/A5)scIL-5, in which the only charged residue in the CD loop is an Arg at position 90.	Arginine	149-152	interleukin 5	Homo sapiens	57-61
10407101-1	1999	Nitric oxide (NO) is a highly diffusible cellular mediator generated from L-arginine by the enzyme nitric oxide synthase (NOS).	Arginine	74-84	nitric oxide synthase 1	Homo sapiens	99-120
1357118-2	1992	The natural amino acid at this position (arginine in GluR2 but glutamine in GluR1, GluR3, and GluR4) determines both the ability to pass outward current and the divalent cation permeability of kainate-activated receptor channels.	Arginine	41-49	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	53-58
1357118-2	1992	The natural amino acid at this position (arginine in GluR2 but glutamine in GluR1, GluR3, and GluR4) determines both the ability to pass outward current and the divalent cation permeability of kainate-activated receptor channels.	Arginine	41-49	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	83-88
1357118-4	1992	Additional mutations at and near this site in GluR3 indicated that the position of the arginine is critical to function, that the ability to pass outward current is not necessarily linked to low barium permeability, and that the size as well as the charge of the side chain at this position influences barium permeation.	Arginine	87-95	glutamate ionotropic receptor AMPA type subunit 3	Homo sapiens	46-51
10381364-2	1999	The carboxyl-terminal end of MAL has the sequence Phe-Ser-Leu-Ile-Arg-Trp-Lys-Ser-Ser (FSLIRWKSS), which includes the LIRW motif necessary for sorting MAL to GEMs, and whose last five amino acids resemble dilysine-based signals involved in endoplasmic reticulum (ER) retention.	Arginine	66-69	mal, T cell differentiation protein	Canis lupus familiaris	151-154
10387045-9	1999	272, 17349], but somewhat similar to those of a relatively stable O2 adduct of L-Arg-free full-length nNOS (lambdamax = 415-416.5 nm) generated at -30 degrees C [Bec, N., Gorren, A. C. F., Voelder, C., Mayer, B., and Lange, R. (1998) J. Biol.	Arginine	79-84	nitric oxide synthase 1	Homo sapiens	102-106
1527019-4	1992	The receptor, which consisted of two polypeptides of relative molecular masses of 150 and 116 kDa, bound to the entactin-Sepharose matrix in the presence of CaCl2, MgCl2, and MnCl2, and was eluted with EDTA, but not with Arg-Gly-Asp-containing peptides.	Arginine	221-224	nidogen 1	Homo sapiens	112-120
10330339-8	1999	An Arg-->His substitution was identified, which was associated with a late age at onset and protracted clinical phenotype, in a number of other patients originally diagnosed with juvenile NCL.	Arginine	3-6	nucleolin	Homo sapiens	188-191
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	163-166	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
10370135-2	1999	It is generated from l-arginine by nitric oxide synthases (NOS), which come in three isoforms depending on the tissue of origin, namely inducible-NOS (iNOS in macrophages), endothelial-NOS (eNOS in endothelial cells) and neural-NOS (nNOS in neural cells).	Arginine	21-31	nitric oxide synthase 1, neuronal	Mus musculus	233-237
1639022-4	1992	The data indicate that exogenous TRH enhances basal glucagon secretion; inversely, anti-TRH serum inhibits glucose plus arginine-induced glucagon secretion and produces a concomitant slight inhibition of somatostatin secretion.	Arginine	120-128	thyrotropin releasing hormone	Rattus norvegicus	33-36
1639022-4	1992	The data indicate that exogenous TRH enhances basal glucagon secretion; inversely, anti-TRH serum inhibits glucose plus arginine-induced glucagon secretion and produces a concomitant slight inhibition of somatostatin secretion.	Arginine	120-128	thyrotropin releasing hormone	Rattus norvegicus	88-91
1641777-4	1992	We investigated the influence of tumor necrosis factor (TNF) on the activity of System y(+)-mediated hepatocyte arginine transport employing hepatic plasma membrane vesicles (HPMVs).	Arginine	112-120	tumor necrosis factor-like	Rattus norvegicus	33-54
10411640-7	1999	HK2 cleaves substrates C-terminal of single or double arginines.	Arginine	54-63	hexokinase 2	Homo sapiens	0-3
1641777-4	1992	We investigated the influence of tumor necrosis factor (TNF) on the activity of System y(+)-mediated hepatocyte arginine transport employing hepatic plasma membrane vesicles (HPMVs).	Arginine	112-120	tumor necrosis factor-like	Rattus norvegicus	56-59
10336483-6	1999	Site-directed mutagenesis of three conserved Arg in the RP- domain of CaM-KK confirmed that these positive charges are important for CaM-KIV activation.	Arginine	45-48	calcium/calmodulin dependent protein kinase IV	Homo sapiens	133-140
1641777-11	1992	Inhibition analysis indicated that the TNF-induced increase in saturable arginine transport activity was mediated by an increase in System y+.	Arginine	73-81	tumor necrosis factor-like	Rattus norvegicus	39-42
1641777-13	1992	CONCLUSIONS: In vivo treatment with TNF results in a rapid stimulation of saturable, System y(+)-mediated arginine transport in the liver.	Arginine	106-114	tumor necrosis factor-like	Rattus norvegicus	36-39
11593518-0	1999	Dietary L-arginine attenuates expression of vascular cell adhesion molecule-1 in the aortae of hypercholesterolemic rats.	Arginine	8-18	vascular cell adhesion molecule 1	Rattus norvegicus	44-77
1641777-14	1992	This TNF-induced stimulation of hepatic arginine transport may serve to increase the normally restricted availability of extrahepatic arginine to the hepatocyte intracellular space during a septic insult to support important arginine-dependent pathways in the liver.	Arginine	40-48	tumor necrosis factor-like	Rattus norvegicus	5-8
1641777-14	1992	This TNF-induced stimulation of hepatic arginine transport may serve to increase the normally restricted availability of extrahepatic arginine to the hepatocyte intracellular space during a septic insult to support important arginine-dependent pathways in the liver.	Arginine	134-142	tumor necrosis factor-like	Rattus norvegicus	5-8
1641777-14	1992	This TNF-induced stimulation of hepatic arginine transport may serve to increase the normally restricted availability of extrahepatic arginine to the hepatocyte intracellular space during a septic insult to support important arginine-dependent pathways in the liver.	Arginine	134-142	tumor necrosis factor-like	Rattus norvegicus	5-8
11593518-1	1999	OBJECTIVE: To determine whether the antiatherogenic effect of L-arginine is due to an inhibition of vascular cell adhesion molecule-1 (VCAM-1) expression in the aortae of hypercholesterolemic rats.	Arginine	62-72	vascular cell adhesion molecule 1	Rattus norvegicus	100-133
11593518-1	1999	OBJECTIVE: To determine whether the antiatherogenic effect of L-arginine is due to an inhibition of vascular cell adhesion molecule-1 (VCAM-1) expression in the aortae of hypercholesterolemic rats.	Arginine	62-72	vascular cell adhesion molecule 1	Rattus norvegicus	135-141
10090758-1	1999	Recently, we used 35 GHz pulsed 15N ENDOR spectroscopy to determine the position of the reactive guanidino nitrogen of substrate L-arginine relative to the high-spin ferriheme iron of holo-neuronal nitric oxide synthase (nNOS) [Tierney, D. L., et al.	Arginine	129-139	nitric oxide synthase 1	Homo sapiens	221-225
1459318-6	1992	A significant enrichment in DQA1 alleles encoding for Arginine at position 52 in diabetic children was also observed (82% vs 40%; p &lt; 10(-8)).	Arginine	54-62	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	28-32
1380405-6	1992	Besides the conversion of L-arginine, type I NOS, Ca2+/calmodulin dependently, generates H2O2 and reduces cytochrome c/P450.	Arginine	26-36	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	119-123
10075657-9	1999	The Ile-33 --&gt; Gln point mutant completely inhibited and Arg-38 --&gt; Gln and Ser-36 --&gt; Asp point mutants reduced neurogranin/CaM interactions.	Arginine	60-63	neurogranin	Homo sapiens	122-133
1612233-0	1992	Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles.	Arginine	141-144	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	128-140
10064737-10	1999	We conclude that amino acid residues arginine 160 and proline 165 of apoA-I contribute to the formation of a domain that is very important for initial lipid binding and contributes to LCAT-activation and promotion of initial cholesterol efflux but not to the stabilization of preformed rLpA-I.	Arginine	37-45	lecithin cholesterol acyltransferase	Mus musculus	184-188
1304916-0	1992	Characterization of the structure and properties of the His 62--&gt;Ala and Arg 38--&gt;Ala mutants of yeast phosphoglycerate kinase: an investigation of the catalytic and activatory sites by site-directed mutagenesis and NMR.	Arginine	76-79	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	109-132
10189112-5	1999	Brain nitric oxide synthase (NOS) activity in the cerebral cortex and medulla oblongata, assessed by the conversion of labelled arginine to citrulline, was inhibited by 48% and 44% after the intraperitoneal administration of 7-NI.	Arginine	128-136	nitric oxide synthase, brain	Oryctolagus cuniculus	6-27
1573269-12	1992	These results are consistent with the sole defect in the mutants being at the C5 binding stage and strongly suggest that Arg 458 of the C4 beta-chain contributes to the C5 binding site of the molecule.	Arginine	121-124	complement C4B (Chido blood group)	Homo sapiens	136-143
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Arginine	58-66	pregnancy specific beta-1-glycoprotein 8	Homo sapiens	39-43
9971738-2	1999	As NO is synthesized by NO synthase (NOS) from arginine, a common substrate of arginase, these two enzymes compete for arginine.	Arginine	47-55	nitric oxide synthase 1, neuronal	Mus musculus	24-35
1557353-3	1992	The PR264 polypeptide, which contains a typical ribonucleoprotein 80 and an arginine/serine-rich domain, is highly homologous to the Drosophila splicing regulators tra, tra-2, and su(wa) and to the human alternative splicing factor ASF/SF2.	Arginine	76-84	serine and arginine rich splicing factor 2	Homo sapiens	4-9
9971738-2	1999	As NO is synthesized by NO synthase (NOS) from arginine, a common substrate of arginase, these two enzymes compete for arginine.	Arginine	119-127	nitric oxide synthase 1, neuronal	Mus musculus	24-35
9931346-8	1999	A novel allele ( TPMT*8 ), containing a single nucleotide transition (G644A), leading to an amino acid change at codon 215 (Arg--&gt;His), was found in one African-American with intermediate activity.	Arginine	124-127	thiopurine S-methyltransferase	Homo sapiens	17-21
1421205-0	1992	Effects of dexamethasone on TRH and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) levels in various rat organs.	Arginine	63-66	thyrotropin releasing hormone	Rattus norvegicus	36-39
1421205-0	1992	Effects of dexamethasone on TRH and TRH precursor peptide (Lys-Arg-Gln-His-Pro-Gly-Arg-Arg) levels in various rat organs.	Arginine	83-86	thyrotropin releasing hormone	Rattus norvegicus	36-39
1311296-0	1992	arcD, the first gene of the arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa, encodes an arginine-ornithine exchanger.	Arginine	53-61	hypothetical protein	Escherichia coli	0-4
10065874-1	1999	Nitric oxide (NO), derived from L-arginine by the action of nitric oxide synthase (NOS), is a mediator of many diverse biological activities, including vasodilation, neurotransmission and inhibition of platelet adhesion.	Arginine	32-42	nitric oxide synthase 1	Homo sapiens	60-81
10025963-15	1999	The data indicate that the His-81 in the second transmembrane domain of the PGF2alpha receptor in concert with Arg-291 in the seventh transmembrane domain may be involved in ligand binding, most likely not by ionic interaction with the prostaglandin"s carboxyl group but rather as a hydrogen bond donor.	Arginine	111-114	prostaglandin F receptor	Homo sapiens	76-94
1311296-11	1992	It is concluded that the ArcD protein is a transport system that catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway.	Arginine	110-118	hypothetical protein	Escherichia coli	25-29
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	104-107	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
9923600-4	1999	Plasmin cleaves gp160 precisely at the C-terminal arginine residue of gp120, and the processing is effectively inhibited by an analogue peptide of the cleavage motif (RXK/RR) and by plasmin inhibitors.	Arginine	50-58	plasminogen	Homo sapiens	0-7
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	114-117	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	114-117	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	167-170	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	177-180	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	177-180	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
1587790-7	1992	These observations support the notion that furin is the endogenous endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	114-117	furin, paired basic amino acid cleaving enzyme	Homo sapiens	43-48
1587790-7	1992	These observations support the notion that furin is the endogenous endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	124-127	furin, paired basic amino acid cleaving enzyme	Homo sapiens	43-48
9923600-4	1999	Plasmin cleaves gp160 precisely at the C-terminal arginine residue of gp120, and the processing is effectively inhibited by an analogue peptide of the cleavage motif (RXK/RR) and by plasmin inhibitors.	Arginine	50-58	glutamyl aminopeptidase	Homo sapiens	16-21
1587790-7	1992	These observations support the notion that furin is the endogenous endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	124-127	furin, paired basic amino acid cleaving enzyme	Homo sapiens	43-48
9920509-7	1999	In competition experiments, LDL, apoE, polymers of lysine and arginine were all capable of preventing the lipase specific [125I]Lp(a) retention.	Arginine	62-70	lipoprotein(a)	Homo sapiens	128-133
1318546-10	1992	In the only human apo[a] polymorph sequenced to date, position 4308 is occupied by serine, whereas the homologous position in plasmin is occupied by arginine and is an important site for proteolytic cleavage and activation.	Arginine	149-157	lipoprotein(a)	Homo sapiens	18-23
1318546-10	1992	In the only human apo[a] polymorph sequenced to date, position 4308 is occupied by serine, whereas the homologous position in plasmin is occupied by arginine and is an important site for proteolytic cleavage and activation.	Arginine	149-157	plasminogen	Homo sapiens	126-133
10503941-4	1999	7-ER is a noncompetitive inhibitor of nNOS with respect to L-arginine with a Ki value of 0.76 +/- 0.06 microM.	Arginine	59-69	nitric oxide synthase 1	Homo sapiens	38-42
1370372-8	1992	It is suggested that the positive charge contributed by the arginine of the edited GluR-B(R) subunit determines low divalent permeability in heteromeric GluR channels and that changes in GluR-B(R) expression regulate the AMPA receptor-dependent divalent permeability of a cell.	Arginine	60-68	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	83-89
1721880-4	1991	L-Homoarginine and L-arginine-containing small peptides, such as L-arginyl-L-phenylalanine, replaced L-arginine as a substrate for the NOSc in EC and the Ca(2+)-independent NOSi in J774.2 cells, but not the Ca(2+)-dependent NOSi.	Arginine	19-29	nitric oxide synthase 1, neuronal	Mus musculus	173-177
1721880-4	1991	L-Homoarginine and L-arginine-containing small peptides, such as L-arginyl-L-phenylalanine, replaced L-arginine as a substrate for the NOSc in EC and the Ca(2+)-independent NOSi in J774.2 cells, but not the Ca(2+)-dependent NOSi.	Arginine	19-29	nitric oxide synthase 1, neuronal	Mus musculus	224-228
10413210-4	1999	The allele FcgammaRIIA-H131 encodes a receptor with a histidine at the 131 amino acid position; the other allele FcgammaRIIA-R131 encodes an arginine.	Arginine	141-149	Fc gamma receptor IIa	Homo sapiens	113-124
1721880-4	1991	L-Homoarginine and L-arginine-containing small peptides, such as L-arginyl-L-phenylalanine, replaced L-arginine as a substrate for the NOSc in EC and the Ca(2+)-independent NOSi in J774.2 cells, but not the Ca(2+)-dependent NOSi.	Arginine	101-111	nitric oxide synthase 1, neuronal	Mus musculus	173-177
1721880-4	1991	L-Homoarginine and L-arginine-containing small peptides, such as L-arginyl-L-phenylalanine, replaced L-arginine as a substrate for the NOSc in EC and the Ca(2+)-independent NOSi in J774.2 cells, but not the Ca(2+)-dependent NOSi.	Arginine	101-111	nitric oxide synthase 1, neuronal	Mus musculus	224-228
10097286-11	1999	This study further shows that APC converts coagulation factor V into a member of the anticoagulant pathway by cleaving factor V in the A2 domain at Arg 506.	Arginine	148-151	APC regulator of WNT signaling pathway	Homo sapiens	30-33
1808766-0	1991	A common point mutation producing type 1A antithrombin III deficiency: AT129 CGA to TGA (Arg to Stop).	Arginine	89-92	T-box transcription factor 1	Homo sapiens	84-87
10461108-3	1999	MDCK cells (2 x 10(6) cells/well) were cultured to a confluent state, and the binding of OPN to the cellular surface was then inhibited by adding one of the following 4 substances: human OPN polyclonal antibody, thrombin, cyclic Arg-Gly-Asp (RGD) peptides and tunicamycin.	Arginine	229-232	secreted phosphoprotein 1	Canis lupus familiaris	89-92
1658185-5	1991	When Mos were incubated with L-arginine (0.25-2.0 mM), their rate of pHi recovery declined progressively from 2 to 6 h of incubation.	Arginine	29-39	glucose-6-phosphate isomerase 1	Mus musculus	69-72
1658185-7	1991	The impairment of pHi recovery was specific for L-arginine, and was blocked competitively by NG-monomethyl-L-arginine, demonstrating its dependence on L-arginine metabolism.	Arginine	48-58	glucose-6-phosphate isomerase 1	Mus musculus	18-21
1658185-7	1991	The impairment of pHi recovery was specific for L-arginine, and was blocked competitively by NG-monomethyl-L-arginine, demonstrating its dependence on L-arginine metabolism.	Arginine	107-117	glucose-6-phosphate isomerase 1	Mus musculus	18-21
1658185-8	1991	In addition, the inhibition of pHi recovery was enhanced by lipopolysaccharide, an agent known to stimulate L-arginine metabolism by Mos.	Arginine	108-118	glucose-6-phosphate isomerase 1	Mus musculus	31-34
1658185-9	1991	Scavenging the L-arginine metabolite nitric oxide with either ferrous sulphate or ferrous myoglobin prevented the inhibition of pHi recovery, implying that L-arginine-derived nitric oxide was the species responsible for the inhibition.	Arginine	15-25	glucose-6-phosphate isomerase 1	Mus musculus	128-131
9826510-2	1998	SM3 recognises the core repeating motif (Pro-Asp-Thr-Arg-Pro) of aberrantly glycosylated epithelial mucin MUC1, and has potential as a therapeutic and diagnostic tool.	Arginine	53-56	mucin 1, cell surface associated	Homo sapiens	106-110
1658185-9	1991	Scavenging the L-arginine metabolite nitric oxide with either ferrous sulphate or ferrous myoglobin prevented the inhibition of pHi recovery, implying that L-arginine-derived nitric oxide was the species responsible for the inhibition.	Arginine	156-166	glucose-6-phosphate isomerase 1	Mus musculus	128-131
1658185-12	1991	Treatment with the cyclic GMP analogue, 8-bromoguanosine 3":5"-cyclic monophosphate, similarly impaired Mo pHi recovery, suggesting that a nitric oxide-stimulated elevation of cyclic GMP may contribute to the L-arginine-dependent inhibition of pHi regulation.	Arginine	209-219	5'-nucleotidase, cytosolic II	Mus musculus	183-186
9874237-1	1998	In this work we have characterised the transport of L-arginine and L-ornithine into mitochondria isolated from a wild-type Saccharomyces cerevisiae strain and an isogenic arg11 knock-out mutant.	Arginine	52-62	Ort1p	Saccharomyces cerevisiae S288C	171-176
1716439-7	1991	rMNK1 and mMNK1 differed from a recently reported MAP-2 kinase cDNA, termed ERK1, because of a nonconservative change in position 82, from Gly in ERK1 to Arg in rMNK1.	Arginine	154-157	mitogen activated protein kinase 3	Rattus norvegicus	0-5
1716439-7	1991	rMNK1 and mMNK1 differed from a recently reported MAP-2 kinase cDNA, termed ERK1, because of a nonconservative change in position 82, from Gly in ERK1 to Arg in rMNK1.	Arginine	154-157	mitogen-activated protein kinase 3	Mus musculus	10-15
9874237-2	1998	The Arg11 protein (Arg11p) is a mitochondrial carrier required for arginine biosynthesis [Crabeel, M., Soetens, O., De Rijcke, M., Pratiwi, R. &amp; Pankiewicz, R. (1996) J. Biol.	Arginine	67-75	Ort1p	Saccharomyces cerevisiae S288C	4-9
1716439-7	1991	rMNK1 and mMNK1 differed from a recently reported MAP-2 kinase cDNA, termed ERK1, because of a nonconservative change in position 82, from Gly in ERK1 to Arg in rMNK1.	Arginine	154-157	mitogen activated protein kinase 3	Rattus norvegicus	76-80
1716439-7	1991	rMNK1 and mMNK1 differed from a recently reported MAP-2 kinase cDNA, termed ERK1, because of a nonconservative change in position 82, from Gly in ERK1 to Arg in rMNK1.	Arginine	154-157	mitogen activated protein kinase 3	Rattus norvegicus	161-166
9874237-2	1998	The Arg11 protein (Arg11p) is a mitochondrial carrier required for arginine biosynthesis [Crabeel, M., Soetens, O., De Rijcke, M., Pratiwi, R. &amp; Pankiewicz, R. (1996) J. Biol.	Arginine	67-75	Ort1p	Saccharomyces cerevisiae S288C	19-25
9874237-8	1998	Evidence is presented here that the mitochondrial inner membrane contains an L-arginine and L-ornithine transporting system distinct from Arg11p, in keeping with the arginine leaky phenotype of arg11 knock-out mutants.	Arginine	77-87	Ort1p	Saccharomyces cerevisiae S288C	194-199
9874237-8	1998	Evidence is presented here that the mitochondrial inner membrane contains an L-arginine and L-ornithine transporting system distinct from Arg11p, in keeping with the arginine leaky phenotype of arg11 knock-out mutants.	Arginine	79-87	Ort1p	Saccharomyces cerevisiae S288C	194-199
1715576-0	1991	Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.	Arginine	119-127	Rev	Human immunodeficiency virus 1	83-86
1715576-7	1991	Thus, Rev"s arginine-rich motif participates in two distinct functions: oligomerization and RNA binding.	Arginine	12-20	Rev	Human immunodeficiency virus 1	6-9
9790985-0	1998	Isoelectrofocusing phenotype and relative concentration of transcobalamin II isoproteins related to the codon 259 Arg/Pro polymorphism.	Arginine	114-117	transcobalamin 2	Homo sapiens	59-76
9792286-2	1998	Sequencing of the VWF gene region coding for the FVIII binding domain revealed the most frequent type 2N mutation: a single nucleotide change (G2811A) in exon 20, resulting in substitution of glutamine (Gln) for arginine (Arg) 91 in the mature VWF protein in one allele.	Arginine	212-220	coagulation factor VIII	Homo sapiens	49-54
1831451-0	1991	Active arginine residues in beta-hexosaminidase.	Arginine	7-15	O-GlcNAcase	Homo sapiens	28-47
9792286-2	1998	Sequencing of the VWF gene region coding for the FVIII binding domain revealed the most frequent type 2N mutation: a single nucleotide change (G2811A) in exon 20, resulting in substitution of glutamine (Gln) for arginine (Arg) 91 in the mature VWF protein in one allele.	Arginine	222-225	coagulation factor VIII	Homo sapiens	49-54
9801989-12	1998	In elderly subjects, the GH response to HEX (22.4 +/- 4.9; 855.0 +/- 199.0 micrograms/l/h) was higher (p &lt; 0.01) than that to GHRH (3.6 +/- 0.8 micrograms/l; 151.8 +/- 24.6 micrograms/l/h) but lower (p &lt; 0.05) than that to ARG + GHRH (48.1 +/- 4.6 micrograms/l; 1758.2 +/- 149.1 micrograms/l/h).	Arginine	229-232	hematopoietically expressed homeobox	Homo sapiens	40-43
1659747-9	1991	In the third experiment the RGDS peptide (ARG-GLY-ASP-SER), a blocker of GPIIb/IIIa platelet receptor dose dependently inhibited platelet aggregation by 93 +/- 17%.	Arginine	42-45	ral guanine nucleotide dissociation stimulator	Homo sapiens	28-32
2049401-2	1991	L-Arginine was converted to L-citrulline either directly in a NADPH-sensitive manner thought to be coupled with the generation of NO, or indirectly through the sequence of reactions catalyzed by arginase and ornithine transcarbamylase.	Arginine	0-10	ornithine transcarbamylase	Rattus norvegicus	208-234
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Arginine	258-266	general transcription factor IIA subunit 1	Homo sapiens	200-205
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Arginine	320-323	prolactin receptor	Homo sapiens	89-102
2014261-2	1991	Competition experiments followed by mutational analysis show that the epitope on hGH for hPRL receptor consists of strong determinants in the middle of helix 1 (comprising residues His-18, His-21, and Phe-25), a loop region (including Ile-58, Ser-62, and Asn-63), and the central portion of helix 4 (containing residues Arg-167, Lys-168, Lys-172, Glu-174, Phe-176, and Arg-178).	Arginine	369-372	prolactin receptor	Homo sapiens	89-102
9685421-3	1998	ASF/SF2, SC35, and other members of the serine/arginine family, interact with the 70k protein of the U1 small nuclear ribonucleoprotein.	Arginine	47-55	serine and arginine rich splicing factor 2	Homo sapiens	9-13
9685421-8	1998	Mutational analysis of this segment suggested that several arginines are critical for the interaction with ASF/SF2 and for phosphorylation by SRPK1.	Arginine	59-68	SRSF protein kinase 1	Homo sapiens	142-147
2052001-9	1991	Cowper"s gland mucin glycoprotein had a similar carboxyl terminal sequence, -Val-Ala-Tyr-Leu-Phe-Arg-Arg-COOH.	Arginine	97-100	LOC100508689	Homo sapiens	15-20
2052001-9	1991	Cowper"s gland mucin glycoprotein had a similar carboxyl terminal sequence, -Val-Ala-Tyr-Leu-Phe-Arg-Arg-COOH.	Arginine	101-104	LOC100508689	Homo sapiens	15-20
9662426-4	1998	The results indicate that the MAPK/ERK and SAPK2/p38 cascades are both rate-limiting for LPS- and IFNgamma-stimulated arginine uptake, but not for iNOS synthesis.	Arginine	118-126	mitogen-activated protein kinase 14	Mus musculus	49-52
1999411-5	1991	The single substitution of lysine (or arginine) for Ser-7 transformed the pig pancreatic PLA-2 into an active enzyme toward BPI-treated E. coli possessing 25-50% the activity of the human PLA-2.	Arginine	38-46	bactericidal permeability increasing protein	Sus scrofa	124-127
9627013-7	1998	Reactivity of the Y12 MAb with S10 protein was abolished by deletion of 19 amino acids at the carboxyl-terminus of S10, containing the Gly-Arg-Gly sequence motif shared by Sm-B/B" and Sm-D (D1 and D3).	Arginine	139-142	ribosomal protein S10	Homo sapiens	31-34
9627013-7	1998	Reactivity of the Y12 MAb with S10 protein was abolished by deletion of 19 amino acids at the carboxyl-terminus of S10, containing the Gly-Arg-Gly sequence motif shared by Sm-B/B" and Sm-D (D1 and D3).	Arginine	139-142	ribosomal protein S10	Homo sapiens	115-118
1867999-7	1991	These results suggest that the presence of the arginine-rich H1c subtype would neither be compatible with the relaxed structure of acetylated chromatin present in active replicating cells nor with the hyperacetylated chromatin characteristic of postreplicative late spermatids undergoing the nucleohistone nucleoprotamine transition.	Arginine	47-55	H1.2 linker histone, cluster member	Mus musculus	61-64
9627013-10	1998	The carboxyl-terminal Gly-Arg-Gly region of S10 protein is involved in constructing the cross-reactive epitope.	Arginine	26-29	ribosomal protein S10	Homo sapiens	44-47
9600966-12	1998	These findings underscore the key role of Arg-589 and the C terminus in normal AE1 function, and indicate that while mutations in AE1 cause autosomal dominant dRTA, defects in this gene are not responsible for recessive disease.	Arginine	42-45	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	130-133
1998680-2	1991	Human Q31, murine, and human granzyme A hydrolyzed Arg- or Lys-containing thioesters very efficiently with kcat/KM of 10(4)-10(5) M-1 s-1.	Arginine	51-54	granzyme A	Homo sapiens	29-39
9576908-7	1998	The form of Fhit bound to two ApppA substrates would present to the cell a dramatically phosphorylated surface, prominently displaying six phosphate groups and two adenosine moieties in place of a deep cavity lined with histidines, arginines, and glutamines.	Arginine	232-241	fragile histidine triad diadenosine triphosphatase	Homo sapiens	12-16
2085183-2	1990	The method is based upon the use of two different substrates, argininosuccinate and arginine for ASase and arginase, respectively, and the measurement of only one final metabolite: ornithine.	Arginine	84-92	adenylosuccinate lyase	Homo sapiens	97-102
2085183-3	1990	The use of ornithine as a marker of biological activity of ASase is related to the fact that in the urea cycle, the specific activity of arginase is much higher than that of ASase; thus, during in vitro determinations, arginine, which is the product of ASase, is rapidly converted to ornithine.	Arginine	219-227	adenylosuccinate lyase	Homo sapiens	59-64
9556608-6	1998	Both brain and recombinant neuropsin had amidolytic activities cleaving Arg-X and Lys-X bonds in the synthetic chromogenic substrates, and the highest specific activity was found against Boc-Val-Pro-Arg-4-methylcoumaryl-7-amide.	Arginine	72-75	opsin 5	Mus musculus	27-36
2279701-2	1990	Alteration of the tetra-basic amino acid sequence (Arg84-Arg-Lys-Arg to Arg-Ser-Asn-Gly) results in the formation of stable pro-PDGF-A homodimers that lack mitogenic activity.	Arginine	51-54	platelet derived growth factor, alpha	Mus musculus	128-134
9557754-4	1998	Furin most likely recognizes one of three potential cleavage sites, namely, an arginine at position 249 of the ORF-IV gene product.	Arginine	79-87	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
2128973-0	1990	Fibrin specific thrombolysis by two-chain urokinase-type plasminogen activator cleaved after arginine 156 by thrombin.	Arginine	93-101	urokinase-type plasminogen activator	Oryctolagus cuniculus	42-78
9698284-2	1998	The aim of the present study was to examine, for the first time in pigs, the dose-dependent effect of arginine (ARG) on growth hormone (GH) and insulin release and the effect of the combined ARG and aspartic acid (ASP) treatment on GH and insulin release.	Arginine	102-110	insulin	Sus scrofa	144-151
2149860-1	1990	Partially purified selenoprotein P from rat plasma was digested with either trypsin, endoprotease Lys-C, or endoprotease Arg-C and analyzed by high pressure liquid chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis.	Arginine	121-124	selenoprotein P	Rattus norvegicus	19-34
9698284-2	1998	The aim of the present study was to examine, for the first time in pigs, the dose-dependent effect of arginine (ARG) on growth hormone (GH) and insulin release and the effect of the combined ARG and aspartic acid (ASP) treatment on GH and insulin release.	Arginine	112-115	insulin	Sus scrofa	144-151
9535869-2	1998	Nitric oxide synthase (NOS) catalyzes the NADPH- and O2-dependent conversion of L-arginine to nitric oxide (NO) and citrulline; three isoforms, the neuronal (nNOS), endothelial, and inducible, have been identified.	Arginine	80-90	nitric oxide synthase 1	Homo sapiens	0-21
9535869-2	1998	Nitric oxide synthase (NOS) catalyzes the NADPH- and O2-dependent conversion of L-arginine to nitric oxide (NO) and citrulline; three isoforms, the neuronal (nNOS), endothelial, and inducible, have been identified.	Arginine	80-90	nitric oxide synthase 1	Homo sapiens	158-162
2143190-6	1990	In this paper, the structural and functional role of the lysine and arginine residues of the TCR alpha chain was addressed using oligonucleotide mediated site directed mutagenesis.	Arginine	68-76	T cell receptor alpha constant	Homo sapiens	93-102
9535869-5	1998	In the present studies we report that vinyl-L-NIO (N5-(1-imino-3-butenyl)-L-ornithine; L-VNIO) binds to and inhibits nNOS in competition with L-arginine (Ki = 100 nM); binding is accompanied by a type I optical difference spectrum consistent with binding near the heme cofactor without interaction as a sixth axial heme ligand.	Arginine	142-152	nitric oxide synthase 1	Homo sapiens	117-121
9535869-11	1998	Among the NOS inactivating L-arginine derivatives, L-VNIO is the most potent and nNOS-selective reported to date.	Arginine	27-37	nitric oxide synthase 1	Homo sapiens	81-85
9546718-2	1998	Bovine UCRP retains the Leu-Arg-Gly-Gly C-terminal sequence of ubiquitin that ligates to and directs degradation of cytosolic proteins.	Arginine	28-31	ubiquitin	Bos taurus	63-72
2364072-3	1990	It is concluded that the transport function of bilitranslocase depends on arginine residues, which are involved in the interaction with the molecules to be translocated.	Arginine	74-82	ceruloplasmin	Rattus norvegicus	47-62
9510178-4	1998	We have used segmental exchanges and site-directed mutagenesis to identify the residues in rat TAP2 responsible for differential transport between the two alleles of peptides terminating above all in the positively charged residue, arginine.	Arginine	232-240	transporter 2, ATP binding cassette subfamily B member	Rattus norvegicus	95-99
1974459-3	1990	ApoJ is synthesized as a 427 amino acid polypeptide that is posttranslationally cleaved at an internal bond between Arg-205 and Ser-206.	Arginine	116-119	clusterin	Homo sapiens	0-4
9510178-5	1998	Of the 25 residues by which the two functional TAP2 alleles differ, we have localized differential transport of peptides with a C-terminal arginine to two adjacent clusters of exchanges in the membrane domain involving a total of five amino acids.	Arginine	139-147	transporter 2, ATP binding cassette subfamily B member	Rattus norvegicus	47-51
9499091-7	1998	In the case of Cys-, Leu-, Asn-, Gln-, or Arg-nsP4, revertants that were indistinguishable in plaque phenotype from the wild-type virus arose by same-site reversion to Tyr, Trp, Phe, or His by a single nucleotide substitution in the original mutant codon.	Arginine	42-45	serine protease 57	Homo sapiens	46-50
9499091-8	1998	Viable viruses also arose from the Ala-, Leu-, Cys-, Thr-, Asn-, Gln-, and Arg-nsP4 mutants that retained the original mutations at the N terminus of nsP4, but these viruses formed smaller plaques than the wild-type virus and many were temperature sensitive.	Arginine	75-78	serine protease 57	Homo sapiens	79-83
9512712-7	1998	In contrast, Pro67--&gt;Arg prevents LexA cleavage while allowing nearly 50% of wild-type induction of UmuD cleavage.	Arginine	24-27	UmuD	Escherichia coli	103-107
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Arginine	103-106	thyrotropin releasing hormone	Homo sapiens	0-3
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Arginine	127-130	thyrotropin releasing hormone	Homo sapiens	0-3
2117583-2	1990	TRH derives from a 242-amino acid precursor protein, prepro-TRH, with six repetitive sequences of -Lys-Arg-Gln-His-Pro-Gly-Lys/Arg)-Arg- connected by hydrophobic linking sequences.	Arginine	127-130	thyrotropin releasing hormone	Homo sapiens	0-3
9442015-1	1998	Furin is a ubiquitous prototypical mammalian kexin/subtilisin-like endoproteinase that is involved in the proteolytic processing of a variety of proteins in the exocytic and endocytic pathways, with cleavage occurring at the C terminus of the minimal consensus furin recognition sequence Arg-Xaa-Xaa-Arg.	Arginine	288-291	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
2117583-7	1990	A minor, TRH-Gly immunoreactive peak increased 50-fold (P less than 0.001) during 20 h at 60 degrees C. This material co-eluted with Arg-Gln-His-Pro-Gly which is formed by enzymic cleavage of the paired basic residues flanking this sequence in prepro-TRH.	Arginine	133-136	thyrotropin releasing hormone	Homo sapiens	9-12
2117583-7	1990	A minor, TRH-Gly immunoreactive peak increased 50-fold (P less than 0.001) during 20 h at 60 degrees C. This material co-eluted with Arg-Gln-His-Pro-Gly which is formed by enzymic cleavage of the paired basic residues flanking this sequence in prepro-TRH.	Arginine	133-136	thyrotropin releasing hormone	Homo sapiens	251-254
2117583-8	1990	When synthetic Arg-Gln-His-Pro-Gly was incubated with fresh semen at 60 degrees C a rapid conversion of most of this peptide to Glu-His-Pro-Gly, Gln-His-Pro-Gly and TRH-Gly occurred within 30 min.	Arginine	15-18	thyrotropin releasing hormone	Homo sapiens	165-168
9442015-1	1998	Furin is a ubiquitous prototypical mammalian kexin/subtilisin-like endoproteinase that is involved in the proteolytic processing of a variety of proteins in the exocytic and endocytic pathways, with cleavage occurring at the C terminus of the minimal consensus furin recognition sequence Arg-Xaa-Xaa-Arg.	Arginine	300-303	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
9458786-5	1998	These findings indicate that vagal efferent activation induced by TRH analog injected intracisternally at a gastric acid secretory dose increases GMBF through atropine-sensitive mechanisms stimulating L-arginine-nitric oxide pathways, whereas H1 receptors and capsaicin-sensitive afferent fibers do not play a role.	Arginine	201-211	thyrotropin releasing hormone	Rattus norvegicus	66-69
2113484-0	1990	TRH-extended peptides in the olfactory lobe are formed by incomplete cleavage at pairs of arginine residues in the TRH prohormone.	Arginine	90-98	thyrotropin releasing hormone	Rattus norvegicus	0-3
2113484-0	1990	TRH-extended peptides in the olfactory lobe are formed by incomplete cleavage at pairs of arginine residues in the TRH prohormone.	Arginine	90-98	thyrotropin releasing hormone	Rattus norvegicus	115-118
2113484-2	1990	TRH-extended peptides have been detected in the rat olfactory lobe: these peptides accounted for approximately 11% of the total TRH immunoreactivity present in the tissue and contained the sequence pGlu-His-Pro-Gly-Arg exclusively at their N-termini.	Arginine	215-218	thyrotropin releasing hormone	Rattus norvegicus	0-3
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	93-96	insulin receptor	Homo sapiens	3-19
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	101-104	insulin receptor	Homo sapiens	3-19
2187866-1	1990	An insulin receptor mutant was constructed utilizing site-directed mutagenesis to delete the Arg-Lys-Arg-Arg basic amino acid cleavage site (positions 720-723) from the cDNA encoding the human insulin proreceptor.	Arginine	101-104	insulin receptor	Homo sapiens	3-19
9523173-5	1998	Plasma renin activity in the L-Arg group was less than in the CsA (18 +/- 2 vs. 23 +/- 3 ng Ang I/ml/h, p &lt; 0.05) and the L-NAME groups (vs. 30 +/- 3 ng Ang I/ml/h, p &lt; 0.05).	Arginine	29-34	renin	Rattus norvegicus	7-12
2342104-6	1990	Arginine 45 adopts a well-ordered conformation similar to that found in aquomet sperm whale myoglobin.	Arginine	0-8	myoglobin	Physeter catodon	92-101
9752719-6	1998	A second methyltransferase activity that symmetrically dimethylates an arginine residue in myelin basic protein, a major component of the axon sheath, has also been characterized.	Arginine	71-79	myelin basic protein	Homo sapiens	91-111
1973901-3	1990	The first C of this codon has been substituted by T resulting in the non-conservative substitution of cysteine for arginine at an essential thrombin cleavage site in factor VIII.	Arginine	115-123	cytochrome c oxidase subunit 8A	Homo sapiens	173-177
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	210-213	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
9459333-0	1998	Characterization of monoclonal anti-human factor VII antibody (B101/B1) that recognized three-dimensional structures near Arg at position 79 in the first EGF-like domain.	Arginine	122-125	CD80 molecule	Homo sapiens	63-70
9405039-5	1997	With these peptides, the recognition sequence for gamma-PAK has been shown to contain two basic amino acids in the -2 and -3 positions, as represented by (K/R)RXS, in which the -2 position is an arginine, the -3 position is an arginine or a lysine, and X can be an acidic, basic, or neutral amino acid.	Arginine	195-203	p21 (RAC1) activated kinase 2	Homo sapiens	50-59
1696522-4	1990	The levels of c-myc transcripts were elevated three-fold with an arginine-deficient diet but were little changed with a high-orotate diet.	Arginine	65-73	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	14-19
9405039-5	1997	With these peptides, the recognition sequence for gamma-PAK has been shown to contain two basic amino acids in the -2 and -3 positions, as represented by (K/R)RXS, in which the -2 position is an arginine, the -3 position is an arginine or a lysine, and X can be an acidic, basic, or neutral amino acid.	Arginine	227-235	p21 (RAC1) activated kinase 2	Homo sapiens	50-59
2182021-3	1990	Infusion of 50 microM L-NMMA inhibited the vasodilation induced by 10(-13) M ET-3 and rather elicited an increase in perfusion pressure, which itself was decreased by infusion of 150 microM L-arginine.	Arginine	190-200	endothelin 3	Rattus norvegicus	77-81
9382895-0	1997	A conserved arginine residue in the pore region of an inward rectifier K channel (IRK1) as an external barrier for cationic blockers.	Arginine	12-20	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	82-86
2158926-0	1990	The arc operon for anaerobic arginine catabolism in Pseudomonas aeruginosa contains an additional gene, arcD, encoding a membrane protein.	Arginine	29-37	hypothetical protein	Escherichia coli	104-108
2158926-7	1990	Mutations in arcD rendered the cells unable to utilize extracellular arginine as an energy source.	Arginine	69-77	hypothetical protein	Escherichia coli	13-17
9367756-5	1997	Each zinc finger contacts four to five base-pairs and the repertoire of known base contact residues is extended to include a tryptophan at position +2 of the helix (finger 1) and arginine at position +10 (finger 3).	Arginine	179-187	Yip1 domain family member 3 S homeolog	Xenopus laevis	205-213
2158926-8	1990	Since anaerobic arginine consumption and ornithine release are coupled in P. aeruginosa, it is proposed that arcD specifies an arginine: ornithine antiporter or a part thereof.	Arginine	16-24	hypothetical protein	Escherichia coli	109-113
2158926-8	1990	Since anaerobic arginine consumption and ornithine release are coupled in P. aeruginosa, it is proposed that arcD specifies an arginine: ornithine antiporter or a part thereof.	Arginine	127-135	hypothetical protein	Escherichia coli	109-113
9409415-5	1997	Quantification of both resting rCBF and rVR using IMP-ARG method could provide reliable information concerning on surgical indication and its effectiveness in childhood Moyamoya disease.	Arginine	54-57	CCAAT/enhancer binding protein zeta	Rattus norvegicus	31-35
2303410-12	1990	While two of the three mutant pro-NPY molecules were processed to wild-type carboxyl-terminal peptide, the carboxyl-terminal peptide derived from pro-NPY(-Arg-Lys-) contained an amino-terminal lysine residue, indicating that biosynthetic endoproteolysis occurred in the middle or at the amino terminus of the pair of basic amino acid residues at the cleavage site.	Arginine	155-158	neuropeptide Y	Mus musculus	146-153
9399582-5	1997	The order of Kcat/Km values of AAP at optimal pH (pH 7.5) was Ala- &gt; Lys-Ala- &gt; or = Met- &gt; Leu- &gt; Phe- &gt; Arg- &gt; or = Arg-Arg- &gt; Lys- &gt; Gly-MCAs.	Arginine	121-124	alanyl aminopeptidase, membrane	Homo sapiens	31-34
9399582-5	1997	The order of Kcat/Km values of AAP at optimal pH (pH 7.5) was Ala- &gt; Lys-Ala- &gt; or = Met- &gt; Leu- &gt; Phe- &gt; Arg- &gt; or = Arg-Arg- &gt; Lys- &gt; Gly-MCAs.	Arginine	136-139	alanyl aminopeptidase, membrane	Homo sapiens	31-34
9399582-5	1997	The order of Kcat/Km values of AAP at optimal pH (pH 7.5) was Ala- &gt; Lys-Ala- &gt; or = Met- &gt; Leu- &gt; Phe- &gt; Arg- &gt; or = Arg-Arg- &gt; Lys- &gt; Gly-MCAs.	Arginine	136-139	alanyl aminopeptidase, membrane	Homo sapiens	31-34
1688630-3	1990	One-half of the MAbs tested mapped to the amino-terminal proline-rich region, and one-third of the MAbs tested mapped to the lysine-arginine-rich region of tat.	Arginine	132-140	tyrosine aminotransferase	Homo sapiens	156-159
9326784-1	1997	The objective of this study was to examine whether the administration of L-arginine, a precursor of nitric oxide and substrate of nitric oxide synthase, prior to reperfusion could lead to decrease in neutrophil-mediated tissue injury and improved flap survival.	Arginine	73-83	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	247-251
2367346-0	1990	Purification of nodule-specific uricase from soybean by arginine-sepharose affinity chromatography.	Arginine	56-64	uricase-2 isozyme 1	Glycine max	32-39
2367346-3	1990	Crude extracts were loaded onto small columns of Arginine-Sepharose and a significant retardation of uricase was observed.	Arginine	49-57	uricase-2 isozyme 1	Glycine max	101-108
2104682-2	1990	Site-specific mutagenesis was used to construct a mutant of the human immunodeficiency virus type 1 (HIV-1) in which the arginine residue at the carboxy-terminus of the gp120 was changed to a threonine residue.	Arginine	121-129	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	169-174
2104682-10	1990	The data indicate that the carboxy-terminal arginine residue of HIV-1 gp120 is necessary for envelope protein cleavage and suggest cleavage is important in the virus life cycle in both functional virus release and membrane fusion.	Arginine	44-52	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	70-75
9326784-9	1997	We conclude that administration of L-arginine prior to reperfusion can significantly reduce the extent of flap necrosis and flap neutrophil counts due to ischemia-reperfusion injury.	Arginine	35-45	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	106-110
9326784-11	1997	Since L-arginine reduces the number of neutrophils within the flap and the extent of flap necrosis only in the presence of active nitric oxide synthase, we hypothesize that this protective effect of L-arginine on ischemia-reperfusion injury is secondary to a nitric oxide-mediated suppression of neutrophil-mediated injury.	Arginine	6-16	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	62-66
9266190-5	1997	The c1039 C--&gt;T substitution, found in the gene of GPI "Zwickau", has been described recently [30] and causes an Arg 347--&gt;Cys substitution close to the putative catalytic site.	Arginine	116-119	glucose-6-phosphate isomerase	Homo sapiens	54-57
9235940-11	1997	We conclude that selected lysine and arginine residues on the surface of DNase I constitute the major elements of the phosphotransferase recognition domain present on this secretory glycoprotein.	Arginine	37-45	deoxyribonuclease 1	Bos taurus	73-80
9269960-0	1997	The effect of arginine supplementation on growth hormone release and intestinal mucosal growth after massive small bowel resection in growing rats.	Arginine	14-22	gonadotropin releasing hormone receptor	Rattus norvegicus	42-56
9269960-8	1997	Growth hormone-releasing hormone (GHRH) provocative tests (1 microg per rat, intravenously) showed the more significant elevation of growth hormone IGH) secretion in the arginine supplement group than that of glycine supplement group at 5 minutes (P &lt; .05).	Arginine	170-178	growth hormone releasing hormone	Rattus norvegicus	0-32
9269960-8	1997	Growth hormone-releasing hormone (GHRH) provocative tests (1 microg per rat, intravenously) showed the more significant elevation of growth hormone IGH) secretion in the arginine supplement group than that of glycine supplement group at 5 minutes (P &lt; .05).	Arginine	170-178	growth hormone releasing hormone	Rattus norvegicus	34-38
9269960-8	1997	Growth hormone-releasing hormone (GHRH) provocative tests (1 microg per rat, intravenously) showed the more significant elevation of growth hormone IGH) secretion in the arginine supplement group than that of glycine supplement group at 5 minutes (P &lt; .05).	Arginine	170-178	gonadotropin releasing hormone receptor	Rattus norvegicus	133-147
9248702-7	1997	Addition of Arg residues at B31-32, on the backbone of either HI or AspB10 HI, increased affinity for the IGF-I receptor 10 and 28 fold, respectively, compared to HI, confirming the significance of enhanced positive charge at the C-terminal end of the insulin B-chain in increasing selectivity for the IGF-I receptor.	Arginine	12-15	cytohesin 1 interacting protein	Homo sapiens	28-31
9225798-1	1997	UNLABELLED: We recently proposed a simplified technique for measuring regional cerebral blood flow (rCBF) using the [123I]N-isopropyl-p-iodoamphetamine (IMP) autoradiographic (ARG) method with SPECT (the IMP-ARG method).	Arginine	176-179	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
9225798-1	1997	UNLABELLED: We recently proposed a simplified technique for measuring regional cerebral blood flow (rCBF) using the [123I]N-isopropyl-p-iodoamphetamine (IMP) autoradiographic (ARG) method with SPECT (the IMP-ARG method).	Arginine	208-211	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
9225798-13	1997	CONCLUSION: The IMP-ARG method is reproducible, sensitive to hypoperfusion and feasible for the quantitative evaluation of rCBF in routine clinical practice.	Arginine	20-23	CCAAT/enhancer binding protein zeta	Rattus norvegicus	123-127
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	121-124	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
9266488-16	1997	Instead, H3 and H5 were found to be moderately potent inhibitors of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate.	Arginine	133-136	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
9162031-0	1997	Arginine 200 of heparin cofactor II promotes intramolecular interactions of the acidic domain.	Arginine	0-8	serpin family D member 1	Homo sapiens	16-35
9115288-3	1997	Site-directed mutagenesis indicated that a number of residues including arginine 19, cysteine 122, histidine 126, glutamic acid 152, arginine 155, and methionine 167 were needed for protection of SSAT by BE-3-4-3.	Arginine	72-80	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	196-200
9115288-3	1997	Site-directed mutagenesis indicated that a number of residues including arginine 19, cysteine 122, histidine 126, glutamic acid 152, arginine 155, and methionine 167 were needed for protection of SSAT by BE-3-4-3.	Arginine	133-141	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	196-200
9103452-3	1997	Inhibition of NO production in LPS-treated macrophages by either the L-arginine analogue N(G)-monomethyl-L-arginine (L-NMMA) or aminoguanidine was accompanied by an additional enhancement of Cox activity parallel to the expression of Cox-2 protein analyzed by Western blot.	Arginine	69-79	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	234-239
9128204-13	1997	Brain L-arginine thus appears to exert pressor actions through stimulation of the brain renin-angiotensin system and peripheral SNA.	Arginine	6-16	renin	Rattus norvegicus	88-93
9096824-8	1997	RESULTS: NO synthesis precursor, L-arginine (20, 40, 200, 800 mg/kg), resulted in a dose-dependent decrease in the ACT in mice, while the NO synthase (NOS) inhibitor, NG-nitro-L-arginine-methyl ester (L-NAME, 1.25, 2.50, 5.00 mg/kg, i.p.)	Arginine	33-43	nitric oxide synthase 1, neuronal	Mus musculus	138-149
9155960-1	1997	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	31-41	nitric oxide synthase 1	Homo sapiens	45-66
9155960-1	1997	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	31-41	nitric oxide synthase 1	Homo sapiens	141-155
9155960-1	1997	Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), which has at least three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	31-41	nitric oxide synthase 1	Homo sapiens	157-161
9130696-1	1997	Activation of furin requires autoproteolytic cleavage of its 83-amino acid propeptide at the consensus furin site, Arg-Thr-Lys-Arg107/.	Arginine	115-118	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
9130696-8	1997	Co-immunoprecipitation studies coupled with analysis by mass spectrometry show that release of the propeptide at acidic pH, and hence activation of furin, requires a second cleavage within the autoinhibitory domain at a site containing a P6 arginine (-Arg70-Gly-Val-Thr-Lys-Arg75/-).	Arginine	241-249	furin, paired basic amino acid cleaving enzyme	Homo sapiens	148-153
9156047-6	1997	RESULTS: A germline missense point mutation at codon 238 of the vhl gene (CGG--&gt;TGG; Arg--&gt;Trp) was detected in all patients with phaeochromocytoma and in only one of the asymptomatic family members.	Arginine	88-91	von Hippel-Lindau tumor suppressor	Homo sapiens	64-67
9058595-0	1997	Arginine 52 and histidine 54 located in a conserved amino-terminal hydrophobic region (LX2-R52-G-H54-X3-V-L) are important amino acids for the functional and structural integrity of the human liver UDP-glucuronosyltransferase UGT1*6.	Arginine	0-8	UDP glucuronosyltransferase family 1 member A6	Homo sapiens	226-232
9013624-9	1997	Arginase I mRNA was induced markedly and more slowly in both tissues, reaching a maximum in 12 h. Thus, arginase I appears to have an important role in down-regulating nitric oxide synthesis in murine macrophages by decreasing the availability of arginine, and the induction of arginase I is mediated by C/EBPbeta.	Arginine	247-255	arginase, liver	Mus musculus	0-10
9013624-9	1997	Arginase I mRNA was induced markedly and more slowly in both tissues, reaching a maximum in 12 h. Thus, arginase I appears to have an important role in down-regulating nitric oxide synthesis in murine macrophages by decreasing the availability of arginine, and the induction of arginase I is mediated by C/EBPbeta.	Arginine	247-255	arginase, liver	Mus musculus	104-114
9225111-5	1997	A single base difference (base 1167) in the domain encoding GnRH results in the same amino acid, arginine, in position 8, whereas four base differences (bases 1200, 1253, 1268, 1292) in the domain encoding GnRH-associated peptide (GAP) result in four different amino acids in position 19, 37, 42, and 50.	Arginine	97-105	gonadotropin releasing hormone 1	Homo sapiens	60-64
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 1	Homo sapiens	35-56
33766692-4	2021	Herein, we report for the first time, ASC-targeted delivery of trans-resveratrol (R), a representative agent, using ligand-coated R-encapsulated nanoparticles (L-Rnano) that selectively bind to glycanation site-deficient decorin receptors on ASCs.	Arginine	82-83	steroid sulfatase	Mus musculus	38-41
33787218-3	2021	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	neuropilin 1	Homo sapiens	140-145
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 1	Homo sapiens	122-136
9065701-2	1997	NO is generated from L-arginine by nitric oxide synthase (NOS), which has three isoforms; endothelial-type NOS (eNOS) and brain-type NOS (bNOS) are constitutive enzymes, and inducible-type NOS (iNOS) is expressed after stimulation.	Arginine	21-31	nitric oxide synthase 1	Homo sapiens	138-142
9051589-0	1997	Diabetes and insulin-induced stimulation of L-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands.	Arginine	44-54	insulin	Oryctolagus cuniculus	13-20
9051589-20	1997	The differential modulation of L-arginine transport by insulin and L-arginine identified in non-diabetic and diabetic glands, may be of importance in protecting the gastric mucosa from injuries associated with diabetes.	Arginine	31-41	insulin	Oryctolagus cuniculus	55-62
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
9431549-1	1997	Recent studies suggested that the L-arginine/nitric oxide (NO)/cyclic GMP pathway is involved in the modulation of pain perception.	Arginine	34-44	5'-nucleotidase, cytosolic II	Mus musculus	70-73
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
34923393-6	2022	We predict that the two positively charged arginine residues (Arg409 and Arg413) in the exosite-2 region, the beta- and gamma-insertion loops of thrombin play an important structural role in the initial activating complex between fXI and thrombin.	Arginine	43-51	coagulation factor XI	Homo sapiens	230-233
8943218-5	1996	RED2 further differs from RED1 in having a 54-residue amino-terminal extension which includes an arginine-rich motif.	Arginine	97-105	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	0-4
34780773-1	2022	Arginase 1 (A1) is the enzyme that hydrolyzes the amino acid, L-arginine, to ornithine and urea.	Arginine	62-72	arginase, liver	Mus musculus	0-10
8943297-9	1996	We propose that: (i) alpha-D258 is a Mor "contact site"; and (ii) residues Leu-262, Arg-265, and Asn-268 indirectly affect Mor-polymerase interaction by stabilizing the ternary complex via alpha-DNA contact.	Arginine	84-87	Mor	Escherichia phage Mu	123-126
8982281-3	1996	Thus, an arginine residue in position 16 reduced 3-fold the affinity of secretin for secretin receptors but increased 30-fold its affinity for the VIP1 and PACAP I receptors.	Arginine	9-17	adenylate cyclase activating polypeptide 1	Rattus norvegicus	156-161
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	adenylate cyclase activating polypeptide 1	Rattus norvegicus	89-94
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	adenylate cyclase activating polypeptide 1	Rattus norvegicus	137-142
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	adenylate cyclase activating polypeptide 1	Rattus norvegicus	137-142
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	adenylate cyclase activating polypeptide 1	Rattus norvegicus	137-142
8945558-3	1996	Two amino acid residues, Arg-136 and Asp-347, were identified as the residues binding to STa in the extracellular domain of pig STaR by site-directed mutagenesis and analysis of expression on 293T cells.	Arginine	25-28	steroidogenic acute regulatory protein	Sus scrofa	128-132
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Arginine	255-263	adenosine deaminase	Mus musculus	124-143
8942668-1	1996	His 238, a conserved amino acid located in hydrogen-bonding distance from C-6 of the substrate in the active site of murine adenosine deaminase (mADA) and postulated to play an important role in catalysis, was altered into an alanine, a glutamate, and an arginine using site-directed mutagenesis.	Arginine	255-263	adenosine deaminase	Mus musculus	145-149
8939939-13	1996	Biochemical analysis of lysates from these cells showed that the Arg to His conversion interrupted the interaction between the 97-kDa subunit and protein disulfide isomerase.	Arginine	65-68	prolyl 4-hydroxylase subunit beta	Homo sapiens	146-173
8896427-1	1996	Nitric oxide (NO) generated from L-arginine and molecular oxygen by nitric oxide synthase (NOS) has been shown to influence hepatocellular function and pathology in response to ischemia and certain hepatotoxins.	Arginine	33-43	nitric oxide synthase 1, neuronal	Mus musculus	68-89
8824195-6	1996	Between the first and second PDZ domains, ZO-2 displays a basic region (pI = 10.27) containing 22% arginine residues.	Arginine	99-107	tight junction protein 2	Canis lupus familiaris	42-46
8824206-0	1996	Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2+-ATPase produces pumps defective in ATP binding.	Arginine	34-37	dynein axonemal heavy chain 8	Homo sapiens	84-90
8824206-0	1996	Mutagenesis of segment 487Phe-Ser-Arg-Asp-Arg-Lys492 of sarcoplasmic reticulum Ca2+-ATPase produces pumps defective in ATP binding.	Arginine	42-45	dynein axonemal heavy chain 8	Homo sapiens	84-90
8798783-0	1996	The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis.	Arginine	106-114	Ort1p	Saccharomyces cerevisiae S288C	4-9
8798783-1	1996	Prototype strain MG409 (arg11-1) is a severe arginine bradytroph with greatly reduced ornithine and arginine pools, although all known enzymes required for arginine biosynthesis are functional.	Arginine	45-53	Ort1p	Saccharomyces cerevisiae S288C	24-29
8798783-1	1996	Prototype strain MG409 (arg11-1) is a severe arginine bradytroph with greatly reduced ornithine and arginine pools, although all known enzymes required for arginine biosynthesis are functional.	Arginine	100-108	Ort1p	Saccharomyces cerevisiae S288C	24-29
8798783-1	1996	Prototype strain MG409 (arg11-1) is a severe arginine bradytroph with greatly reduced ornithine and arginine pools, although all known enzymes required for arginine biosynthesis are functional.	Arginine	100-108	Ort1p	Saccharomyces cerevisiae S288C	24-29
8798783-2	1996	To identify the function required for normal arginine production impaired in MG409, we have cloned, sequenced, and performed a first molecular characterization of ARG11.	Arginine	45-53	Ort1p	Saccharomyces cerevisiae S288C	163-168
8798783-6	1996	A deletion created in ARG11 causes the same arginine-leaky behavior as the original arg11-1 mutation, which yields a premature stop codon at residue 266.	Arginine	44-52	Ort1p	Saccharomyces cerevisiae S288C	22-27
8904652-3	1996	In the present paper we have investigated, mainly with an in vivo approach, the influence and specificity of the NO synthase (NOS) blocker NG-nitro-L-arginine methyl ester (L-NAME) on L-arginine-induced secretion of insulin and glucagon.	Arginine	148-158	nitric oxide synthase 1, neuronal	Mus musculus	113-124
8841182-2	1996	We now report that an Arg-His substitution at residue 117 of the cationic trypsinogen gene is associated with the HP phenotype.	Arginine	22-25	serine protease 1	Homo sapiens	65-85
34816290-3	2022	METHODS: In Experiments 1 and 2, male and female preweanling rats were given a single pretreatment injection of saline, the 5-HT1A agonist (R)-( +)-8-hydroxy-DPAT (8-OH-DPAT), or the 5-HT1B agonist CP-94253 on PD 20.	Arginine	140-143	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-130
34647407-7	2022	A crystal structure of a peptide with NRP-1 demonstrated that VEGF-B peptides bind at the canonical C-terminal Arginine binding site.	Arginine	111-119	neuropilin 1	Homo sapiens	38-43
8806762-9	1996	As observed with the mammalian neutral endopeptidase, the lactococcal enzyme exhibits higher kcat/K(m) values for the enkephalins than for their corresponding amides, indicating the functionality of an active-site arginine.	Arginine	214-222	pepO	Lactococcus lactis	31-52
8875085-8	1996	During pretreatment test, L-arginine infusion decreased sBP (from 137 +/- 4.1 to 129 +/- 4.5 mmHg, P &lt; 0.01) and dBP (from 79 +/- 1.9 to 75 +/- 1.2 mmHg, P &lt; 0.01) without affecting heart rate or plasma catecholamines.	Arginine	26-36	selenium binding protein 1	Homo sapiens	56-59
34969975-6	2022	The arginine residue R994 of CNGB1 reaches into the ionic pathway and blocks the pore, thus introducing an additional gate, which is different from the central hydrophobic gate known from homomeric CNGA channels.	Arginine	4-12	cyclic nucleotide gated channel subunit beta 1	Bos taurus	29-34
34975499-13	2021	Western blot results demonstrated that colchicine can inhibited MIRI induced apoptosis of H9C2 cell by enhancing the decreased levels of Caspase-3 in myocardial injure model induced by H/R and activating the PI3K/AKT/eNOS pathway.	Arginine	187-188	caspase 3	Rattus norvegicus	137-146
8875085-10	1996	After metformin treatment, the decrease in blood pressure after L-arginine infusion was significantly enhanced, with a maximal decrease of sBP of 12 +/- 3.4 mmHg (8 +/- 2.5 mmHg pretreatment, P &lt; 0.05) and dBP of 9.5 +/- 2.4 mmHg (4.5 +/- 1.9 mmHg pretreatment, P &lt; 0.01).	Arginine	64-74	selenium binding protein 1	Homo sapiens	139-142
8761469-2	1996	Chemical modification of the Ca(2+)-ATPase with phenylglyoxal, as a modifier of arginine residues, leads to an almost total loss of the ATPase activity.	Arginine	80-88	dynein axonemal heavy chain 8	Homo sapiens	36-42
34757726-4	2021	Previously, we showed that proline substitutions in the arginine-rich bridge helix (BH) of Streptococcus pyogenes Cas9 (SpyCas9-L64P-K65P, SpyCas92Pro) improve target DNA cleavage selectivity.	Arginine	56-64	type II CRISPR RNA-guided endonuclease Cas9	Streptococcus pyogenes	114-118
8761469-2	1996	Chemical modification of the Ca(2+)-ATPase with phenylglyoxal, as a modifier of arginine residues, leads to an almost total loss of the ATPase activity.	Arginine	80-88	dynein axonemal heavy chain 8	Homo sapiens	136-142
8704215-4	1996	The underlying mutation was Arg to stop at codon 150 (CGA--&gt;TGA) and was designated R150X, which defined allele Lyon of the EPB3 gene.	Arginine	28-31	T-box transcription factor 1	Homo sapiens	63-66
34960779-6	2021	This results in an optimized directionality of arginine residues involved in interaction of spike with the furin binding pocket, thus improving proteolytic exposure of the viral protein.	Arginine	47-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	92-97
34960779-6	2021	This results in an optimized directionality of arginine residues involved in interaction of spike with the furin binding pocket, thus improving proteolytic exposure of the viral protein.	Arginine	47-55	furin, paired basic amino acid cleaving enzyme	Homo sapiens	107-112
34738040-5	2021	The interleukin (IL)-6 and IL-1 levels in fetal blood and liver tissue as well as the myeloid differentiation primary response 88 (MyD88), transforming growth factor beta (TGFbeta), and nuclear factor kappa B (NF-kappaB) mRNA levels in the fetal liver were decreased (P < 0.05) by the NCG or RP-Arg supplementation compared to the RES treatment.	Arginine	295-298	MYD88 innate immune signal transduction adaptor	Homo sapiens	86-129
34738040-5	2021	The interleukin (IL)-6 and IL-1 levels in fetal blood and liver tissue as well as the myeloid differentiation primary response 88 (MyD88), transforming growth factor beta (TGFbeta), and nuclear factor kappa B (NF-kappaB) mRNA levels in the fetal liver were decreased (P < 0.05) by the NCG or RP-Arg supplementation compared to the RES treatment.	Arginine	295-298	MYD88 innate immune signal transduction adaptor	Homo sapiens	131-136
34738040-5	2021	The interleukin (IL)-6 and IL-1 levels in fetal blood and liver tissue as well as the myeloid differentiation primary response 88 (MyD88), transforming growth factor beta (TGFbeta), and nuclear factor kappa B (NF-kappaB) mRNA levels in the fetal liver were decreased (P < 0.05) by the NCG or RP-Arg supplementation compared to the RES treatment.	Arginine	295-298	transforming growth factor alpha	Homo sapiens	172-179
8704215-4	1996	The underlying mutation was Arg to stop at codon 150 (CGA--&gt;TGA) and was designated R150X, which defined allele Lyon of the EPB3 gene.	Arginine	28-31	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	127-131
34738040-6	2021	Similarly, the toll-like receptor (TLR)-4, MyD88, TGFbeta, and p-c-Jun N-terminal kinase (JNK) protein levels in the fetal liver were reduced (P < 0.05) in the NCG and RP-Arg -supplemented groups compared to the RES group.	Arginine	171-174	MYD88 innate immune signal transduction adaptor	Homo sapiens	43-48
34738040-6	2021	Similarly, the toll-like receptor (TLR)-4, MyD88, TGFbeta, and p-c-Jun N-terminal kinase (JNK) protein levels in the fetal liver were reduced (P < 0.05) in the NCG and RP-Arg -supplemented groups compared to the RES group.	Arginine	171-174	transforming growth factor alpha	Homo sapiens	50-57
8877532-3	1996	The blaIRT gene differs from blaTEM-2 gene by one point mutation which leads to the amino-acid substitution Arg--&gt;Ser at position 244, as observed for the original IRT-2 enzyme derived from TEM-1 reported in Escherichia coli.	Arginine	108-111	hypothetical protein	Escherichia coli	193-198
34287772-0	2021	Safety, PK/PD and preliminary anti-tumor activities of pegylated recombinant human arginase 1 (BCT-100) in patients with advanced arginine auxotrophic tumors.	Arginine	130-138	arginase 1	Homo sapiens	83-93
34534716-1	2021	Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus.	Arginine	128-136	neuropeptide VF precursor	Homo sapiens	27-42
34534716-1	2021	Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) are part of the extended RFamide peptide family characterized by their common arginine (R) and amidated phenylalanine (F)-motif at the carboxyl terminus.	Arginine	128-136	neuropeptide VF precursor	Homo sapiens	44-48
34880885-5	2021	In this study, we isolated one large dumbbell-shaped and asymmetric division chloroplast Arabidopsis mutant Chloroplast Division Mutant 75 (cdm75) that contains a missense mutation, changing the arginine at residue 49 to a histidine (R49H), and this mutant point is located in the N-terminal Conserved Terrestrial Sequence (NCTS) motif of AtMinD1, which is only typically found in terrestrial plants.	Arginine	195-203	septum site-determining protein (MIND)	Arabidopsis thaliana	339-346
34880885-7	2021	Subsequently, we showed that the point mutation of R49H could remove the punctate structure caused by residues 1-62 of the AtMinD1 sequence in the chloroplast, suggesting that the arginine in residue 49 (Arg49) is essential for localizing the punctate structure of AtMinD11 - 62 on the chloroplast envelope.	Arginine	180-188	septum site-determining protein (MIND)	Arabidopsis thaliana	123-130
34867480-7	2021	Interestingly, hypoxia or DMOG upregulates transforming growth factor beta1 (TGFbeta1) levels and collagens Ialpha1, which is prevented by Arg-II silencing, while TGFbeta1-induced collagen Ialpha1 expression is not affected by Arg-II silencing.	Arginine	139-142	transforming growth factor, beta 1	Mus musculus	43-75
34867480-7	2021	Interestingly, hypoxia or DMOG upregulates transforming growth factor beta1 (TGFbeta1) levels and collagens Ialpha1, which is prevented by Arg-II silencing, while TGFbeta1-induced collagen Ialpha1 expression is not affected by Arg-II silencing.	Arginine	139-142	transforming growth factor, beta 1	Mus musculus	77-85
34633199-3	2021	The dealkylation of prismarenes, such as PrS(6)R (R = Et, nPr) and c-PrS(5)Me, can be easily obtained in high yields in the presence of BBr3.	Arginine	47-48	neuronal pentraxin receptor	Homo sapiens	58-61
34731213-7	2021	Amino acids arginine, tyrosine, glutamic acid, tryptophan and asparagine also showed moderate COX-1 and COX-2 inhibition at the same concentration.	Arginine	12-20	cytochrome c oxidase subunit II	Petromyzon marinus	104-109
34418357-1	2021	The enzymes glycine amidinotransferase, mitochondrial (GATM also known as AGAT) and guanidinoacetate N-methyltransferase (GAMT) function together to synthesize creatine from arginine, glycine, and S-Adenosyl methionine.	Arginine	174-182	guanidinoacetate N-methyltransferase	Homo sapiens	84-120
34418357-1	2021	The enzymes glycine amidinotransferase, mitochondrial (GATM also known as AGAT) and guanidinoacetate N-methyltransferase (GAMT) function together to synthesize creatine from arginine, glycine, and S-Adenosyl methionine.	Arginine	174-182	guanidinoacetate N-methyltransferase	Homo sapiens	122-126
34599427-0	2022	Arginase-1 Released into CSF After Aneurysmal Subarachnoid Hemorrhage Decreases Arginine/Ornithine Ratio: a Novel Prognostic Biomarker.	Arginine	80-88	arginase 1	Homo sapiens	0-10
34599427-1	2022	We hypothesized that the enzyme arginase-1 is released into the cerebrospinal fluid (CSF) during red blood cell lysis and contributes to dysregulated metabolism of the nitric oxide (NO) precursor L-arginine during aneurysmal subarachnoid hemorrhage (SAH).	Arginine	196-206	arginase 1	Homo sapiens	32-42
34599427-9	2022	The well-known surrogate parameter for arginase acitivity, the L-arginine to L-ornithine ratio (Arg/Orn), correlated with CSF arginase-1 levels.	Arginine	63-73	arginase 1	Homo sapiens	126-136
34599427-14	2022	We propose a novel mechanism contributing to NO deprivation during SAH: arginase-1 is released from erythrocytes into the CSF, leading to L-arginine consumption and reduced NO bioavailability.	Arginine	138-148	arginase 1	Homo sapiens	72-82
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Arginine	109-117	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	11-12
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Arginine	109-117	neuropilin 1	Homo sapiens	30-42
34722943-4	2021	SARS-CoV-2 S protein binds to neuropilin-1 (NRP1) by virtue of a CendR motif which terminates with either an arginine or lysine.	Arginine	109-117	neuropilin 1	Homo sapiens	44-48
34722943-6	2021	To gain a deeper understanding of additional factors besides the C-terminal arginine that may favour high NRP1 binding, several modelled peptides were investigated using triplicate 1 mus molecular dynamics simulations.	Arginine	76-84	neuropilin 1	Homo sapiens	106-110
34722943-9	2021	Additionally, the results also highlight the relevance of an exposed arginine at its canonical location as capping it blocked arginine from engaging key residues at the NRP1 receptor site that are indispensable for functional binding; and that the presence of proline reinforces the C-terminal arginine.	Arginine	69-77	neuropilin 1	Homo sapiens	169-173
34722943-9	2021	Additionally, the results also highlight the relevance of an exposed arginine at its canonical location as capping it blocked arginine from engaging key residues at the NRP1 receptor site that are indispensable for functional binding; and that the presence of proline reinforces the C-terminal arginine.	Arginine	126-134	neuropilin 1	Homo sapiens	169-173
34454165-7	2021	Notably, the expression levels of Rab7 and Atg5 were markedly up-regulated in MLN4924 treated cells and mice subjected to H2O2 or MI/R, respectively, while knockdown of Sirt1 in cells and heart tissue largely blocked such effect and induced autophagosome accumulation by inhibiting its fusion with lysosomes.	Arginine	133-134	autophagy related 5	Mus musculus	43-47
34660574-7	2021	Replacement of these residues by Arg (RRS K147R,K383R ), creates a SUMO conjugation resistant variant (RRS SCR ).	Arginine	33-36	Arginyl-tRNA synthetase	Drosophila melanogaster	38-41
34660574-7	2021	Replacement of these residues by Arg (RRS K147R,K383R ), creates a SUMO conjugation resistant variant (RRS SCR ).	Arginine	33-36	Arginyl-tRNA synthetase	Drosophila melanogaster	103-106
34573721-3	2021	The main results show the crucial role of arginine in the viability/proliferation of intestinal cells evaluated by an MTT assay, and in the positive regulation of the expression of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6, IL-8) and anti-inflammatory (TGF-beta) cytokines.	Arginine	42-50	tumor necrosis factor	Sus scrofa	199-208
34573721-3	2021	The main results show the crucial role of arginine in the viability/proliferation of intestinal cells evaluated by an MTT assay, and in the positive regulation of the expression of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6, IL-8) and anti-inflammatory (TGF-beta) cytokines.	Arginine	42-50	interleukin 6	Sus scrofa	221-225
34573721-3	2021	The main results show the crucial role of arginine in the viability/proliferation of intestinal cells evaluated by an MTT assay, and in the positive regulation of the expression of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6, IL-8) and anti-inflammatory (TGF-beta) cytokines.	Arginine	42-50	C-X-C motif chemokine ligand 8	Sus scrofa	227-231
34228044-0	2021	HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions.	Arginine	10-18	hydrogen voltage gated channel 1	Homo sapiens	43-46
34352207-0	2021	METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.	Arginine	36-39	methyltransferase 1, tRNA methylguanosine	Homo sapiens	0-6
34440879-4	2021	Additionally, activated GPIIb/IIIa complex (PAC-1) expression was higher on platelets from severe COVID-19 patients compared to healthy controls and inversely correlated with L-arginine plasmatic concentration.	Arginine	175-185	dual specificity phosphatase 2	Homo sapiens	44-49
34440879-5	2021	Notably, MDSC were able to induce PAC-1 expression in vitro by reducing L-arginine concentration, indicating a direct role of PMN-MDSC in platelet activation.	Arginine	72-82	dual specificity phosphatase 2	Homo sapiens	34-39
34184765-2	2021	nSBs repress splicing of hundreds of introns during thermal stress recovery, which are partly regulated by CLK1 kinase phosphorylation of temperature-dependent Ser/Arg-rich splicing factors (SRSFs).	Arginine	164-167	CDC like kinase 1	Homo sapiens	107-111
34326456-1	2021	Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response.	Arginine	77-87	arginase 1	Homo sapiens	6-16
34326456-1	2021	Human Arginase 1 (hArg1) is a metalloenzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea, and modulates T-cell-mediated immune response.	Arginine	77-87	arginase 1	Homo sapiens	18-23
34326297-8	2022	Furthermore, we found that PRMT7 mainly binds to residues 563-566 within the first intracellular loop of hNaV1.9 (hLoop1) and methylates hLoop1 at arginine residue 519.	Arginine	147-155	sodium voltage-gated channel alpha subunit 11	Homo sapiens	105-112
34326848-4	2021	We describe potential mechanisms that the increased arginine metabolism by NOS2 is metabolically coupled with system L transporters LAT1 and LAT2 for the uptake of neutral amino acids, including those that drive mTORC1 signaling toward the M1-like phenotype.	Arginine	52-60	CREB regulated transcription coactivator 1	Mus musculus	212-218
34197501-12	2021	DISCUSSION: This systematic review will help identify HIV-1 Gag gene mutations associated to PI/r-based regimen according to viral subtypes.	Arginine	96-97	Pr55(Gag)	Human immunodeficiency virus 1	60-63
34131176-1	2021	Human neutrophils constitutively express high amounts of arginase-1, which depletes arginine from the surrounding medium and downregulates T-cell activation.	Arginine	84-92	arginase 1	Homo sapiens	57-67
34169098-14	2021	In conclusion, our results suggest that TLR4 activation protects CFs from apoptosis induced by sI/R through the activation of Akt and ERK1/2 signaling pathways.	Arginine	98-99	mitogen activated protein kinase 3	Rattus norvegicus	134-140
34200372-9	2021	A mutant form of the spike protein, lacking the arginine-rich putative furin cleavage site, interacted only weakly with cells and had a lower affinity for unfractionated and low-molecular-weight heparin than the wild-type spike protein.	Arginine	48-56	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	21-26
34200372-9	2021	A mutant form of the spike protein, lacking the arginine-rich putative furin cleavage site, interacted only weakly with cells and had a lower affinity for unfractionated and low-molecular-weight heparin than the wild-type spike protein.	Arginine	48-56	furin, paired basic amino acid cleaving enzyme	Homo sapiens	71-76
35583463-6	2022	Furthermore, l -arginine contributed to the expression of phase II detoxification genes (SULT2B1, GSTA1, GSTM3, and GPX4).	Arginine	13-24	glutathione S-transferase alpha 1	Homo sapiens	98-103
35613279-6	2022	SIRT5 was engineered to resist acylation-driven inhibition via lysine to arginine mutagenesis.	Arginine	73-81	sirtuin 5	Mus musculus	0-5
35627303-3	2022	Because of its short half-life, the modulatory capability of NO is strictly related to the local activity of nitric oxide synthases (Nos), enzymes that synthesize NO from L-arginine, making the localization of Nos mRNAs a reliable indirect proxy for the location of NO action domains, targets, and effectors.	Arginine	171-181	nitric oxide synthase 1 (neuronal)	Danio rerio	109-131
35586977-4	2022	APPROACH AND RESULTS: Using A549 cells transduced with a lentivirus K18 construct and high-throughput screening, we identified the SRC-family tyrosine kinases inhibitor, PP2, as a compound that reverses keratin filament disruption and protects from apoptotic cell death caused by K18 R90C mutation at this highly conserved arginine.	Arginine	323-331	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	170-173
35442666-3	2022	The cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a crucial upstream regulator of the mechanistic target of rapamycin complex 1 (mTORC1) signaling, which has close connections with apoptosis.	Arginine	14-22	CREB regulated transcription coactivator 1	Mus musculus	34-40
35442666-3	2022	The cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a crucial upstream regulator of the mechanistic target of rapamycin complex 1 (mTORC1) signaling, which has close connections with apoptosis.	Arginine	14-22	CREB regulated transcription coactivator 1	Mus musculus	143-149
35490408-2	2022	Mammalian cells expressing CaMKKalpha and CaMKKbeta lacking Arg/Pro-rich insert domain (RP-domain) sequences showed impaired phosphorylation of AMPKalpha, CaMKIalpha, and CaMKIV, whereas the autophosphorylation activities of CaMKK mutants remained intact and were similar to those of wild type CaMKKs.	Arginine	60-63	calcium/calmodulin dependent protein kinase IV	Homo sapiens	171-177
35066566-17	2022	Taken together, our results show that the ROR/miR-185-5p/CDK6 axis modulates cell pyroptosis induced by H/R and the inflammatory response of HCMs.	Arginine	106-107	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	42-45
35403092-9	2022	Results: Glycyrrhizic acid, triterpene glycoside isolated from plants of Glycyrrhiza (licorice) showed interactions with envelope protein at chain A: Arg 61, chain B: Phe 23, chain B: Tyr 57, and chain C: Val 25.	Arginine	150-153	endogenous retrovirus group K member 6, envelope	Homo sapiens	121-137
35500745-7	2022	Thus, our results indicate that PRMT5 mediated symmetric dimethylation at histone H4 arginine 3 (H4R3me2s) is crucial for preventing pathological polyploidization, liver cirrhosis and tumorigenesis in mouse liver.	Arginine	85-93	protein arginine N-methyltransferase 5	Mus musculus	32-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	121-131	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	121-131	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	133-136	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	133-136	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	158-161	glycine amidinotransferase	Rattus norvegicus	0-37
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	158-161	glycine amidinotransferase	Rattus norvegicus	39-43
35563125-2	2022	AGAT also catalyzes the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly   GAA + Orn; equilibrium constant KGAA.	Arginine	73-76	glycine amidinotransferase	Rattus norvegicus	0-4
35563125-2	2022	AGAT also catalyzes the formation of guanidinoacetate (GAA) and Orn from Arg and glycine (Gly): Arg + Gly   GAA + Orn; equilibrium constant KGAA.	Arginine	96-99	glycine amidinotransferase	Rattus norvegicus	0-4
35462078-8	2022	Interestingly, we found two Arginine fingers R68 and R149 that directly interact with the beta-phosphate of the GTP bound in KRas, in a manner similar to what is observed in a crystal structure of GAP-HRas complex, which can facilitate the GPT hydrolysis via the Arginine finger of GTPase-activating protein (GAP).	Arginine	28-36	glutamic--pyruvic transaminase	Homo sapiens	240-243
35426778-13	2022	Significant differences in multiple indices of cardiopulmonary hemodynamics and mean Pro-BNP were also noted after arginine therapy.	Arginine	115-123	natriuretic peptide B	Homo sapiens	89-92
35457018-2	2022	Lysosomal localized amino acid transporter member 9 of the solute carrier family 38 (SLC38A9) regulates essential amino acids" efflux from lysosomes in an arginine-regulated fashion.	Arginine	155-163	solute carrier family 38 member 9	Danio rerio	85-92
35463945-6	2022	We then use site mutation analysis to identify the precise binding sites of ANG in the interaction and found that the 101st residue arginine (R101) represents the critical residue involved in the ANG-ACTN2 interaction.	Arginine	132-140	angiogenin	Homo sapiens	76-79
35463945-6	2022	We then use site mutation analysis to identify the precise binding sites of ANG in the interaction and found that the 101st residue arginine (R101) represents the critical residue involved in the ANG-ACTN2 interaction.	Arginine	132-140	angiogenin	Homo sapiens	196-199
35463945-6	2022	We then use site mutation analysis to identify the precise binding sites of ANG in the interaction and found that the 101st residue arginine (R101) represents the critical residue involved in the ANG-ACTN2 interaction.	Arginine	132-140	actinin alpha 2	Homo sapiens	200-205
35379776-6	2022	We further identified that PRMT5 promoted VCAM-1 expression via symmetrical demethylation of Nuclear factor-kappaB p65 on arginine 30 (R30).	Arginine	122-130	protein arginine N-methyltransferase 5	Mus musculus	27-32
35041539-2	2022	This study explored whether AKAP5 is involved in cardiomyocyte apoptosis induced by H/R and its possible mechanism.	Arginine	86-87	A-kinase anchoring protein 5	Rattus norvegicus	28-33
35311465-12	2022	Moreover, NR4A1 depletion conspicuously promoted cell viability, inhibited oxidative stress as well as inflammation, and induced apoptosis and autophagy in H/R-stimulated BRL-3A cells, which were reversed after radicicol intervention.	Arginine	158-159	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	10-15
34995009-8	2022	PKF115-584 suppressed the effects of ALKBH5 interference on the behaviors of H/R-treated cells.	Arginine	79-80	alkB homolog 5, RNA demethylase	Homo sapiens	37-43
35409175-3	2022	In this work PPIs of alphaB-crystallin and glycogen phosphorylase b (Phb) in the presence of betaine (Bet) and arginine (Arg) at 48  C and ionic strength of 0.15 M were studied using methods of dynamic light scattering, differential scanning calorimetry, and analytical ultracentrifugation.	Arginine	111-119	prohibitin 1	Homo sapiens	69-72
35409175-5	2022	Thus, the anti-aggregation activity of alphaB-crystallin increased in the presence of Bet and decreased under the influence of Arg, which resulted in inhibition or acceleration of Phb aggregation, respectively.	Arginine	127-130	prohibitin 1	Homo sapiens	180-183
35399536-1	2022	Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs).	Arginine	8-16	C9orf72-SMCR8 complex subunit	Homo sapiens	74-81
35424861-1	2022	In this work, ammonium polyphosphate (APP) was surface-modified by bio-based arginine (Arg) for the first time to enhance its flame retardance for fire-safety epoxy resin (EP).	Arginine	77-85	epiregulin	Homo sapiens	172-174
35424861-1	2022	In this work, ammonium polyphosphate (APP) was surface-modified by bio-based arginine (Arg) for the first time to enhance its flame retardance for fire-safety epoxy resin (EP).	Arginine	87-90	epiregulin	Homo sapiens	172-174
35424861-7	2022	When the weight loading of Arg-APP reached 25 wt%, the EP/Arg-APP composite could achieve an LOI value as high as 34.7%, pass V-0 requirements in UL-94 tests, and decrease the peak heat release rate and total smoke production by 83.5% and 61.1% compared with neat EP in CCT, respectively, indicating the superior flame retardance performance of Arg-APP.	Arginine	27-30	epiregulin	Homo sapiens	264-266
35424861-7	2022	When the weight loading of Arg-APP reached 25 wt%, the EP/Arg-APP composite could achieve an LOI value as high as 34.7%, pass V-0 requirements in UL-94 tests, and decrease the peak heat release rate and total smoke production by 83.5% and 61.1% compared with neat EP in CCT, respectively, indicating the superior flame retardance performance of Arg-APP.	Arginine	58-61	epiregulin	Homo sapiens	264-266
35424861-9	2022	At the same additive weight loading (15 wt%), the EP/Arg-APP composite showed higher glass-transition temperature and better tensile-strain properties compared with EP/APP composite, which can be attributed to the Arg shell structure improving the compatibility between APP and the organic substrate.	Arginine	53-56	epiregulin	Homo sapiens	50-52
35424861-9	2022	At the same additive weight loading (15 wt%), the EP/Arg-APP composite showed higher glass-transition temperature and better tensile-strain properties compared with EP/APP composite, which can be attributed to the Arg shell structure improving the compatibility between APP and the organic substrate.	Arginine	214-217	epiregulin	Homo sapiens	50-52
35391841-13	2022	These findings highlight a new mechanism of Rg2-induced cardioprotection: reducing the formation of RIP1/RIP3 necrosome by regulating TAK1 phosphorylation to block necroptosis induced by MI/R.	Arginine	190-191	mitogen-activated protein kinase kinase kinase 7	Mus musculus	134-138
35201898-4	2022	ACE inhibition enhanced micro-opioid receptor activation by Met-enkephalin-Arg-Phe, causing a cell type-specific long-term depression of glutamate release onto medium spiny projection neurons expressing the Drd1 dopamine receptor.	Arginine	75-78	pro-opiomelanocortin-alpha	Mus musculus	60-74
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	phosphoinositide-3-kinase regulatory subunit 4	Homo sapiens	99-105
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	caspase 8	Homo sapiens	107-112
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	regulatory associated protein of MTOR complex 1	Homo sapiens	121-126
35194735-7	2022	The effects of miR-27-3p and/or galectin-3 and HIF-1alpha on the inhibition of cell viability and apoptosis induced by H/R were explored.	Arginine	121-122	galectin 3	Homo sapiens	32-42
35149670-6	2022	However, ISGylation-induced pro-YAP effects were abolished by YAP K497R (K, lysine; R, arginine) mutation, suggesting K497 could be the major YAP ISGylation site.	Arginine	87-95	Yes1 associated transcriptional regulator	Homo sapiens	32-35
35149670-6	2022	However, ISGylation-induced pro-YAP effects were abolished by YAP K497R (K, lysine; R, arginine) mutation, suggesting K497 could be the major YAP ISGylation site.	Arginine	87-95	Yes1 associated transcriptional regulator	Homo sapiens	62-65
35089028-8	2022	These findings indicate that (R)-(18F)13 ((18F)YH149) is a highly promising PET probe for visualizing MAGL non-invasively in vivo and holds great potential to support drug development.	Arginine	29-34	monoglyceride lipase	Mus musculus	102-106
35134872-10	2022	Further studies showed that L-arginine, a GPRC6A agonist, promoted colonic ILC3 expansion and function via mammalian target of rapamycin complex 1 (mTORC1) signalling in vitro.	Arginine	28-38	CREB regulated transcription coactivator 1	Mus musculus	148-154
35069838-7	2022	APPL overexpression-mediated effects were significantly abrogated by compound C. Taken together, the data indicated that APPL1 inhibited ROS production and H/R-induced myocardial injury via the AMPK signaling pathway.	Arginine	158-159	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Rattus norvegicus	121-126
35140112-15	2022	This is distinct from PAD4 citrullination of arginine 197 within NPM which results in its transport from the nucleoli to the nucleoplasm.	Arginine	45-53	nucleophosmin 1	Homo sapiens	65-68
35164214-9	2022	Based on molecular docking results, garcinia acid interacted with the triad arginine residues (Arg118, Arg292, and Arg371) of the viral neuraminidase, implying that this compound has the potential to act as a NA enzyme inhibitor.	Arginine	76-84	neuraminidase 1	Homo sapiens	136-149
35022234-5	2022	GATOR2 mediates amino acid signaling to mTORC1 by directly linking the amino acid sensors for arginine and leucine to downstream signaling complexes.	Arginine	94-102	CREB regulated transcription coactivator 1	Mus musculus	40-46
34992216-0	2022	Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.	Arginine	30-38	C9orf72-SMCR8 complex subunit	Homo sapiens	22-29
35251533-6	2022	We identified residue 493 in delta (glutamine) and omicron (arginine) with altered binding properties towards ACE2.	Arginine	60-68	angiotensin converting enzyme 2	Homo sapiens	110-114
35438581-9	2022	Additionally, the protein levels of TLR4, MyD88 and p-P65 NF-kappaB were obviously increased after H/R stimulation, whereas the addition of UA could alter the phenomena by reducing TLR4, MyD88, and p-P65 NF-kappaB expression.	Arginine	101-102	MYD88 innate immune signal transduction adaptor	Homo sapiens	42-47
35438581-9	2022	Additionally, the protein levels of TLR4, MyD88 and p-P65 NF-kappaB were obviously increased after H/R stimulation, whereas the addition of UA could alter the phenomena by reducing TLR4, MyD88, and p-P65 NF-kappaB expression.	Arginine	101-102	MYD88 innate immune signal transduction adaptor	Homo sapiens	187-192
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	Arginine	62-63	MYD88 innate immune signal transduction adaptor	Homo sapiens	119-124
8869591-9	1996	L-Arginine (1 x 10(-2) M), a NOS substrate, inhibited basal hCG secretion in JEG-3 cells.	Arginine	0-10	chorionic gonadotropin subunit beta 5	Homo sapiens	60-63
8756328-3	1996	The phosphate group, which is on the regulatory T-loop of CDK2, is mostly buried, its charge being neutralized by three Arg side chains.	Arginine	120-123	cyclin dependent kinase 2	Homo sapiens	58-62
8756328-4	1996	The arginines help extend the influence of the phosphate group through a network of hydrogen bonds to both CDK2 and cyclinA.	Arginine	4-13	cyclin dependent kinase 2	Homo sapiens	107-111
9275438-5	1996	RESULTS: The group with PIH showed the following changes: amino acidemia and ammonemia; high aromatic amino acidemia; high threonine, arginine, glycine, cystine and glutamic acidemia.	Arginine	134-142	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	24-27
8663599-7	1996	The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.	Arginine	102-105	phosphomevalonate kinase	Homo sapiens	10-16
8672462-3	1996	The iNOS forms five-coordinate, high-spin complexes with arginine analogs which are clearly related to the corresponding complexes of nNOS.	Arginine	57-65	nitric oxide synthase 1	Homo sapiens	134-138
8672462-4	1996	Studies indicate that the binding of L-arginine, N(omega)-hydroxy-L-arginine (NHA), and N(omega)-methyl-L-arginine (NMA) produces various spectroscopic species closely corresponding to the equivalent complexes of nNOS, while N(omega)-nitro-L-arginine (NNA) binding produces a state which appears intermediate in character between the nNOS NNA and arginine complexes.	Arginine	37-47	nitric oxide synthase 1	Homo sapiens	213-217
8672462-4	1996	Studies indicate that the binding of L-arginine, N(omega)-hydroxy-L-arginine (NHA), and N(omega)-methyl-L-arginine (NMA) produces various spectroscopic species closely corresponding to the equivalent complexes of nNOS, while N(omega)-nitro-L-arginine (NNA) binding produces a state which appears intermediate in character between the nNOS NNA and arginine complexes.	Arginine	37-47	nitric oxide synthase 1	Homo sapiens	334-338
8672462-4	1996	Studies indicate that the binding of L-arginine, N(omega)-hydroxy-L-arginine (NHA), and N(omega)-methyl-L-arginine (NMA) produces various spectroscopic species closely corresponding to the equivalent complexes of nNOS, while N(omega)-nitro-L-arginine (NNA) binding produces a state which appears intermediate in character between the nNOS NNA and arginine complexes.	Arginine	39-47	nitric oxide synthase 1	Homo sapiens	213-217
8672462-4	1996	Studies indicate that the binding of L-arginine, N(omega)-hydroxy-L-arginine (NHA), and N(omega)-methyl-L-arginine (NMA) produces various spectroscopic species closely corresponding to the equivalent complexes of nNOS, while N(omega)-nitro-L-arginine (NNA) binding produces a state which appears intermediate in character between the nNOS NNA and arginine complexes.	Arginine	39-47	nitric oxide synthase 1	Homo sapiens	334-338
8676377-10	1996	The only arginine side-chain built into good density is that of Arg134 at the extracellular end of helix E, the others being disordered near one of the two surfaces.	Arginine	9-17	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	64-70
9206083-2	1996	PATIENTS AND METHODS: Possible heterogeneity in immunogenetic aspects was investigated by comparing the findings on relationship between HLA-DQA1 52 Arg(+) and IDDM predisposition in three groups with different ages of IDDM onset (group A 14 years, group B 15-30 years, group C &gt; 31 years).	Arginine	149-152	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	137-145
9206083-3	1996	RESULTS: The frequency of HLA-DQA1 52 Arg(+) in group A (87.5%) was higher than that in control (53.9%, P &lt; 0.05) and in group B and C (P &lt; 0.05).	Arginine	38-41	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	26-34
9206083-4	1996	The frequency of HLA-DQA1 52 Arg(+)/Arg(+) phenotype in group A (75%) was higher than that in group C (23.1%, P &lt; 0.05).	Arginine	29-32	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	17-25
9206083-4	1996	The frequency of HLA-DQA1 52 Arg(+)/Arg(+) phenotype in group A (75%) was higher than that in group C (23.1%, P &lt; 0.05).	Arginine	36-39	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	17-25
9206083-5	1996	CONCLUSION: The contribution of HLA-DQA1 52 arginine to IDDM susceptibility is heterogeneous.	Arginine	44-52	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	32-40
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Arginine	63-66	fibroblast growth factor 2	Gallus gallus	233-238
8811421-2	1996	Activation of the N-methyl-D-aspartate (NMDA) receptor subtype of glutamate receptors results in the influx of calcium which binds calmodulin and activates neuronal nitric oxide synthase (nNOS), to convent L-arginine to citrulline and nitric oxide (NO).	Arginine	206-216	nitric oxide synthase 1	Homo sapiens	156-186
8811421-2	1996	Activation of the N-methyl-D-aspartate (NMDA) receptor subtype of glutamate receptors results in the influx of calcium which binds calmodulin and activates neuronal nitric oxide synthase (nNOS), to convent L-arginine to citrulline and nitric oxide (NO).	Arginine	206-216	nitric oxide synthase 1	Homo sapiens	188-192
8743501-2	1996	Subsequent studies revealed that EDRF is NO, and is synthesized by mammalian cells from L-arginine through a complex oxidation reaction catalyzed by the flavo-hemoprotein NO synthase (NOS).	Arginine	88-98	nitric oxide synthase 1	Homo sapiens	171-182
8762142-5	1996	Although the far-UV CD spectrum of CRABPI is largely determined by the protein"s secondary structure, aromatic clustering around Trp 87 and the aromatic-charge interaction between Arg 111 and Trp 109 give rise to a characteristic feature in the CD spectrum at 228 nm.	Arginine	180-183	cellular retinoic acid binding protein 1	Homo sapiens	35-41
8662674-1	1996	Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B.	Arginine	14-24	solute carrier family 7 member 1	Rattus norvegicus	56-61
8621565-3	1996	We now demonstrate that pro-MT-MMP-1 mutants are efficiently processed to active proteinases following post-translational endoproteolysis immediately downstream of an Arg108-Arg-Lys-Arg basic motif by a proprotein convertase-dependent pathway.	Arginine	167-170	matrix metallopeptidase 14	Homo sapiens	28-36
8743562-5	1996	MTSP-1 hydrolyzed tert-butyloxycarbonyl (Boc)-Asp(OBzl)Pro-Arg-amino-4-methyl-coumaryl-7-amide (MCA) and Boc-Ile-Glu-Gly-Arg-MCA faster than Boc-Phe-Ser-Arg-MCA.	Arginine	59-62	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	0-6
8743562-5	1996	MTSP-1 hydrolyzed tert-butyloxycarbonyl (Boc)-Asp(OBzl)Pro-Arg-amino-4-methyl-coumaryl-7-amide (MCA) and Boc-Ile-Glu-Gly-Arg-MCA faster than Boc-Phe-Ser-Arg-MCA.	Arginine	121-124	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	0-6
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Arginine	137-140	neurotrophic receptor tyrosine kinase 1	Homo sapiens	74-78
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Arginine	137-140	neurotrophic receptor tyrosine kinase 2	Homo sapiens	83-87
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Arginine	156-159	lipoprotein(a)	Homo sapiens	172-189
8630665-1	1996	In a previous study, we identified a lysine (Lys)-binding-defective form of human lipoprotein(a) and attributed this defect to the presence of a Trp72--&gt;Arg mutation in apolipoprotein(a) [apo(a)] kringle IV-10.	Arginine	156-159	lipoprotein(a)	Homo sapiens	191-197
8839053-1	1996	The Ca(2+)-dependent binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) stimulates the catalytic oxidation of L-arginine to nitric oxide.	Arginine	128-138	nitric oxide synthase 1	Homo sapiens	52-82
8839053-1	1996	The Ca(2+)-dependent binding of calmodulin (CaM) to neuronal nitric oxide synthase (nNOS) stimulates the catalytic oxidation of L-arginine to nitric oxide.	Arginine	128-138	nitric oxide synthase 1	Homo sapiens	84-88
8839053-3	1996	In the presence of suboptimal arginine concentrations, uncoupled turnover of nNOS produces both nitric oxide and superoxide, reactive species which combine to form peroxynitrite.	Arginine	30-38	nitric oxide synthase 1	Homo sapiens	77-81
8839053-7	1996	Incubation of nNOS with suboptimal concentrations of arginine results in sulfoxidation of the CaM methionine residues.	Arginine	53-61	nitric oxide synthase 1	Homo sapiens	14-18
8698438-4	1996	Furthermore, addition of Ng-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, at 10(-3) mol/L significantly blocked the suppressive effect of parathyroid hormone-related protein (1-34) on endothelin-1 secretion, and further addition of 5x10(-3) mol/L L-arginine significantly attenuated the blocking effect of N(G)-monomethyl-L-arginine.	Arginine	39-49	parathyroid hormone like hormone	Homo sapiens	154-189
8611587-1	1996	Neuronal NO synthase (nNOS) consists of a reductase domain that binds FAD, FMN, NADPH, and calmodulin, and an oxygenase domain that binds heme, tetrahydrobiopterin, and the substrate L-arginine.	Arginine	183-193	nitric oxide synthase 1	Homo sapiens	22-26
8611587-9	1996	The observed g values of the nNOS heme were 7.68, and 1.81 and were unchanged by occupation of the substrate binding site by L-arginine or NAME.	Arginine	125-135	nitric oxide synthase 1	Homo sapiens	29-33
8598221-1	1996	The hematopoietic cell recognition sites of human fibronectin (FN) are the Arg-Gly-Asp-Ser (RGDS) sequence recognized by widely distributed integrin receptor alpha 5 beta 1 and the type III connecting segment (III CS) containing two cell-binding sites, designated CS1 and CS5, that are recognized by the alpha 4 beta 1 receptor.	Arginine	75-78	ral guanine nucleotide dissociation stimulator	Homo sapiens	92-96
8598204-2	1996	In one case, the editing alters the gene-encoded glutamine (Q) to an arginine (R) located within the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor subunit GLuR-B.	Arginine	79-80	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	213-219
8598204-2	1996	In one case, the editing alters the gene-encoded glutamine (Q) to an arginine (R) located within the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor subunit GLuR-B.	Arginine	69-77	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	213-219
9095267-7	1996	In addition, all TCC specific for epitope 4 showed an arginine residue in the N-terminal region of their TCRBV CDR3 loops despite their sequence diversities.	Arginine	54-62	CDR3	Homo sapiens	111-115
9079375-9	1996	CONCLUSIONS: The presence of a beta-turn in the Met-Ser-Gly-Arg sequence is strikingly similar to the behavior seen for the corresponding principal neutralizing determinant sequence from gp120 of HIV-1 and argues, in the absence of information of the three-dimensional structure of the intact proteins, for a similarity in the structure of this region that could be exploited in the design of synthetic peptide vaccines generally effective against HIV infections.	Arginine	60-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	187-192
9080192-6	1996	Using this method, we have reproduced the structure of a bovine immunodeficiency virus (BIV) Tat peptide bound to BIV TAR RNA and have developed a model for the structure of the arginine-rich HIV-1 Rev peptide (Rev34-50) interacting with the Rev-binding element (RBE).	Arginine	178-186	Rev	Human immunodeficiency virus 1	198-201
9080192-6	1996	Using this method, we have reproduced the structure of a bovine immunodeficiency virus (BIV) Tat peptide bound to BIV TAR RNA and have developed a model for the structure of the arginine-rich HIV-1 Rev peptide (Rev34-50) interacting with the Rev-binding element (RBE).	Arginine	178-186	Rev	Human immunodeficiency virus 1	211-214
8983022-9	1996	Our results illustrate the potential of the CHO-D3-FUR cell line in the production of recombinant secretory proteins that need endoproteolytic activation at the consensus furin cleavage sequence Arg-X-Lys/Arg-Arg.	Arginine	195-198	furin, paired basic amino acid cleaving enzyme	Homo sapiens	171-176
8983022-9	1996	Our results illustrate the potential of the CHO-D3-FUR cell line in the production of recombinant secretory proteins that need endoproteolytic activation at the consensus furin cleavage sequence Arg-X-Lys/Arg-Arg.	Arginine	205-208	furin, paired basic amino acid cleaving enzyme	Homo sapiens	171-176
8983022-9	1996	Our results illustrate the potential of the CHO-D3-FUR cell line in the production of recombinant secretory proteins that need endoproteolytic activation at the consensus furin cleavage sequence Arg-X-Lys/Arg-Arg.	Arginine	205-208	furin, paired basic amino acid cleaving enzyme	Homo sapiens	171-176
8519750-0	1995	Structure-function analysis of the mammalian DNA polymerase beta active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer.	Arginine	105-113	DNA polymerase beta	Homo sapiens	45-64
8519750-0	1995	Structure-function analysis of the mammalian DNA polymerase beta active site: role of aspartic acid 256, arginine 254, and arginine 258 in nucleotidyl transfer.	Arginine	123-131	DNA polymerase beta	Homo sapiens	45-64
7499343-1	1995	Furin is a membrane-associated endoprotease that catalyzes cleavage of precursor proteins at Arg-X-Lys/Arg-Arg sites.	Arginine	93-96	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7578122-6	1995	The spectral binding constant for L-arginine binding to nNOS (approximately 1.5 microM) is not significantly affected by the presence of 50 microM Zn2+, indicating that Zn(2+)-dependent inhibition of nNOS activity is not due to interference with substrate binding.	Arginine	34-44	nitric oxide synthase 1	Homo sapiens	56-60
7578122-6	1995	The spectral binding constant for L-arginine binding to nNOS (approximately 1.5 microM) is not significantly affected by the presence of 50 microM Zn2+, indicating that Zn(2+)-dependent inhibition of nNOS activity is not due to interference with substrate binding.	Arginine	34-44	nitric oxide synthase 1	Homo sapiens	200-204
7578122-7	1995	The estimated maximal change in nNOS absorbance at approximately 418 nm caused by the L-arginine-dependent conversion of the ferric heme iron from hexacoordinate low-spin to pentacoordinate high-spin is increased by 50% in the presence of 50 microM Zn2+, which reflects the increased initial amount of low-spin ferric heme iron present.	Arginine	86-96	nitric oxide synthase 1	Homo sapiens	32-36
7473744-1	1995	OccR is a transcriptional regulatory protein of Agrobacterium tumefaciens that activates the occQ operon in response to octopine, an arginine derivative released from plant tumors.	Arginine	133-141	hypothetical protein	Agrobacterium tumefaciens	0-4
7592688-10	1995	Four serine pairs, all displaying the Arg/Lys-Ser-Ser motif typical of phosphorylation sites, are present in p21/SIIR between positions 31 and 48.	Arginine	38-41	transcription elongation factor A like 1	Homo sapiens	109-112
7592688-10	1995	Four serine pairs, all displaying the Arg/Lys-Ser-Ser motif typical of phosphorylation sites, are present in p21/SIIR between positions 31 and 48.	Arginine	38-41	transcription elongation factor A like 1	Homo sapiens	113-117
7563086-5	1995	A 40 amino acid peptide containing the arginine-rich RRE binding domain of Rev was also observed to interact with both the RRE and antisense RNA fragments with a binding constant of about 1 x 10(-9) M. However, the peptide displayed almost no ability to discriminate between the RRE and a comparably sized antisense RRE.	Arginine	39-47	Rev	Human immunodeficiency virus 1	75-78
7563086-7	1995	The amino terminus of Rev is likely to maintain the conformational integrity of the arginine rich RRE binding domain which is required for specific RNA binding site discrimination or stabilization of specific Rev-RRE interactions.	Arginine	84-92	Rev	Human immunodeficiency virus 1	22-25
7563086-7	1995	The amino terminus of Rev is likely to maintain the conformational integrity of the arginine rich RRE binding domain which is required for specific RNA binding site discrimination or stabilization of specific Rev-RRE interactions.	Arginine	84-92	Rev	Human immunodeficiency virus 1	209-212
7475134-4	1995	Coronary vascular resistance before and after ischemia were lower in the aspirin plus L-arginine group (0.19 +/- 0.03 dynes.sec/cm5, p = 0.001, and 0.23 +/- 0.04 dynes.sec/cm5, p = 0.01, respectively) compared with those of the control group (0.24 +/- 0.02 and 0.28 +/- 0.07 dynes.sec/cm5, respectively).	Arginine	86-96	Cardiac mass QTL 5	Rattus norvegicus	128-131
7475134-4	1995	Coronary vascular resistance before and after ischemia were lower in the aspirin plus L-arginine group (0.19 +/- 0.03 dynes.sec/cm5, p = 0.001, and 0.23 +/- 0.04 dynes.sec/cm5, p = 0.01, respectively) compared with those of the control group (0.24 +/- 0.02 and 0.28 +/- 0.07 dynes.sec/cm5, respectively).	Arginine	86-96	Cardiac mass QTL 5	Rattus norvegicus	172-175
7475134-4	1995	Coronary vascular resistance before and after ischemia were lower in the aspirin plus L-arginine group (0.19 +/- 0.03 dynes.sec/cm5, p = 0.001, and 0.23 +/- 0.04 dynes.sec/cm5, p = 0.01, respectively) compared with those of the control group (0.24 +/- 0.02 and 0.28 +/- 0.07 dynes.sec/cm5, respectively).	Arginine	86-96	Cardiac mass QTL 5	Rattus norvegicus	172-175
8546274-3	1995	The activity of nitric oxide synthase (NOS) was investigated by the detection of 3H-labeled citrulline formation from 3H-labeled arginine.	Arginine	129-137	nitric oxide synthase, inducible	Cavia porcellus	16-37
8546274-5	1995	The induction of iNOS activity was associated with an associated with an increased level of nitrite, an end metabolite of the l-arginine-NO pathway, in bronchoalveolar lavage fluid.	Arginine	126-136	nitric oxide synthase, inducible	Cavia porcellus	17-21
7642593-2	1995	Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1.	Arginine	13-16	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
7642593-2	1995	Using acetyl-Arg-Ser-Lys-Arg-MCA as model, P4 Arg substitution by Lys or Orn resulted for furin in a 538- and a 280-fold lower kcat/Km value, but only in a 14- and 18-fold decrease for PC1.	Arginine	25-28	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
7544003-3	1995	The present study shows that IgE-IC, via CD23 binding, induce intracellular killing of Leishmania major in human monocyte-derived macrophages through the induction of the L-arginine:NO pathway.	Arginine	171-181	Fc epsilon receptor II	Homo sapiens	41-45
7629143-8	1995	The adhesive motif RGDS (Arg-Gly-Asp-Ser) and an epidermal growth factor-like domain were identified.	Arginine	25-28	ral guanine nucleotide dissociation stimulator	Homo sapiens	19-23
7619075-2	1995	Here we have tested directly the ability of furin to cleave rPSS at the two monobasic sites as well as at the RXRK dibasic site of SS-14 conversion (a furin motif, except for Lys substituting for Arg at P1).	Arginine	196-199	furin, paired basic amino acid cleaving enzyme	Homo sapiens	44-49
7619075-12	1995	Arginine is the preferred residue at the P1 site of furin cleavage.	Arginine	0-8	furin, paired basic amino acid cleaving enzyme	Homo sapiens	52-57
7619075-13	1995	Furin does not process rPSS to PSS-(1-10), suggesting the existence of another monobasic convertase with a preference for Lys rather than Arg at P1.	Arginine	138-141	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7608264-6	1995	An arginine at position 52 on either DQA1 allele was significantly more frequent in patients with IDDM (94%), GD (80%), and AD (89%) compared with controls (66%).	Arginine	3-11	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	37-41
7608264-8	1995	In conclusion, endocrine autoimmunity has a common immunogenetic background; susceptibility is conferred by DQA1*0501 as well as an arginine at position 52 of DQA1 alleles, and protection against IDDM and GD is conferred by DQB1*0602.	Arginine	132-140	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	159-163
7741698-1	1995	Based upon the observed cleavage of various peptidyl substrates by the recombinant prohormone convertases PC1 and furin, an intramolecularly quenched fluorogenic peptidyl substrate, (o-aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg-Ser-Ala-Leu-Arg-Asp-(3-nitro)Ty r-Ala, was synthesized.	Arginine	207-210	furin, paired basic amino acid cleaving enzyme	Homo sapiens	114-119
7741698-4	1995	Both recombinant human PC1 and human furin recognize and cleave specifically this substrate at the expected Arg-Ser site in a sensitive manner.	Arginine	108-111	furin, paired basic amino acid cleaving enzyme	Homo sapiens	37-42
7541690-14	1995	AAAD activity as determined in homogenates (Vmax, in nmol mg-1 protein h-1; Km in microM) was significantly (P &lt; 0.01) higher in rats given L-NAME for 14 days (Vmax = 25 +/- 2; Km = 72 +/- 10) than in control rats (Vmax = 14 +/- 1; Km = 63 +/- 7), rats given L-NAME for 7 days (Vmax = 15 +/- 1; Km = 69 +/- 5) and rats given L-NAME plus L-arginine (Vmax = 13 +/- 1; Km = 60 +/- 3) for 14 days.	Arginine	340-350	dopa decarboxylase	Rattus norvegicus	0-4
7541690-21	1995	The observation that the increased AAAD activity can be reversed by the administration of L-arginine to L-NAME treated rats favours the view that the adaptational response which results in an enhanced AAAD activity probably involves a decrease in the generation of nitric oxide.	Arginine	90-100	dopa decarboxylase	Rattus norvegicus	35-39
7541690-21	1995	The observation that the increased AAAD activity can be reversed by the administration of L-arginine to L-NAME treated rats favours the view that the adaptational response which results in an enhanced AAAD activity probably involves a decrease in the generation of nitric oxide.	Arginine	90-100	dopa decarboxylase	Rattus norvegicus	201-205
7542253-0	1995	Site-directed mutagenesis of the arginine-glycine-aspartic acid sequence in osteopontin destroys cell adhesion and migration functions.	Arginine	33-41	secreted phosphoprotein 1	Mus musculus	76-87
7542253-2	1995	OPN contains a conserved RGD (arg-gly-asp) amino acid sequence that has been implicated in binding of OPN to cell surface integrins.	Arginine	30-33	secreted phosphoprotein 1	Mus musculus	0-3
7542253-2	1995	OPN contains a conserved RGD (arg-gly-asp) amino acid sequence that has been implicated in binding of OPN to cell surface integrins.	Arginine	30-33	secreted phosphoprotein 1	Mus musculus	102-105
7890760-6	1995	A single accessible lysine binding site in Lp(a) is indicated by a complete loss of lysine binding observed for r-Lp(a) species that contain either a truncated r-apo(a) lacking kringle IV-37, kringle V, and the protease or a point-mutated r-apo(a) with a Trp-4174--&gt;Arg substitution in the putative lysine-binding pocket of kringle IV-37.	Arginine	269-272	lipoprotein(a)	Homo sapiens	43-48
7876551-0	1995	Evidence for the involvement of arginine 462 and the flanking sequence of human C4 beta-chain in mediating C5 binding to the C4b subcomponent of the classical complement pathway C5 convertase.	Arginine	32-40	complement C4B (Chido blood group)	Homo sapiens	125-128
7890620-9	1995	The contribution of the Arg-8 side chain is minor, but significant for cystatin C interaction with cathepsin B.	Arginine	24-27	cystatin C	Homo sapiens	71-81
7759311-5	1995	DQA1*0502 represents a single C-to-G transversion in codon 59 (exon 2) and results in an amino acid change from proline to arginine.	Arginine	123-131	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-4
7891043-6	1995	As APC inhibits factor Va by cleavage at arginine 506, mutated factor V is resistant to APC.	Arginine	41-49	APC regulator of WNT signaling pathway	Homo sapiens	3-6
7718542-3	1995	Orn was totally metabolized by the liver, whereas Arg led to Orn release (408 (SD 159) nmol/min per g liver) and a threefold stimulation of urea production (Arg 1.44 (SD 0.22) v. Orn 0.45 (SD 0.09) mumol/min per g liver).	Arginine	50-53	arginase 1	Rattus norvegicus	157-162
7630881-6	1995	Specific acidic residues in the S1 subsite of the substrate binding region of NisP appear to be of particular importance for electrostatic interaction with the P1 Arg residue of precursor nisin after which cleavage occurs.	Arginine	163-166	nisP	Lactococcus lactis	78-82
7639621-8	1995	This L-arginine-derived autacoid, however, plays a role in the release of CGRP from afferent nerve fibres in the skin since it contributes to the CGRP-mediated vasodilator responses to chemical irritation or immunological challenge via interleukin-1 beta.	Arginine	5-15	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
7639621-8	1995	This L-arginine-derived autacoid, however, plays a role in the release of CGRP from afferent nerve fibres in the skin since it contributes to the CGRP-mediated vasodilator responses to chemical irritation or immunological challenge via interleukin-1 beta.	Arginine	5-15	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
7813075-5	1995	Two mutations can occur in kringle 4 type 10: one, Trp72--&gt;Arg, is affiliated with an Lp(a) that is lysine-binding defective; the other, Met66--&gt;Thr, with a normal lysine-binding function.	Arginine	62-65	lipoprotein(a)	Homo sapiens	89-94
7805839-4	1994	The Arg-X-Arg-Arg sequence, which conforms to the recognition site of mammalian furin, occurs in a region just upstream of the putative proteolytic cleavage site of B. mori previtellogenin.	Arginine	4-7	furin, paired basic amino acid cleaving enzyme	Homo sapiens	80-85
7805839-4	1994	The Arg-X-Arg-Arg sequence, which conforms to the recognition site of mammalian furin, occurs in a region just upstream of the putative proteolytic cleavage site of B. mori previtellogenin.	Arginine	10-13	furin, paired basic amino acid cleaving enzyme	Homo sapiens	80-85
7803479-7	1994	Agmatine, the product of arginine decarboxylation catalyzed by arginine decarboxylase, inhibited the SAMDC II competitively (Ki = 40 microM) while it inhibited the SAMDC II non-competitively (Ki = 600 mM).	Arginine	25-33	S-adenosylmethionine decarboxylase	Glycine max	101-106
7740452-0	1994	Alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg) inhibits the contact pathway of intrinsic coagulation and alters the release of human neutrophil elastase during simulated extracorporeal circulation.	Arginine	44-47	elastase, neutrophil expressed	Homo sapiens	135-154
7977788-7	1994	Moreover, L-arginine infusion in L-NAME-treated rats restored the renal response to CGRP.	Arginine	10-20	calcitonin-related polypeptide alpha	Rattus norvegicus	84-88
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	240-248	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	46-50
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	250-253	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	46-50
7821177-7	1994	The presence of four susceptibility residues (two DQA1 Arg 52+ and two DQB1 Asp 57-) conferred the highest relative risk at 20.2.	Arginine	55-58	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	50-54
7821177-8	1994	On the other hand, homozygous genotypes for DQA1 non-Arg 52 and DQB1 Asp 57 were found only in the control group.	Arginine	53-56	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	44-48
7526856-1	1994	Nitric oxide synthase (NOS, EC 1.14.23) catalyzes the oxidation of the guanidino-nitrogen of L-arginine to form nitric oxide and L-citrulline.	Arginine	93-103	nitric oxide synthase 1, neuronal	Mus musculus	0-21
7918682-3	1994	For the first time we now report the occurrence of a human Lp(a) that has a mutant form of apo(a) where Arg has replaced Trp in position 72 of kringle 4-37 and is unable to bind to lysine Sepharose.	Arginine	104-107	lipoprotein(a)	Homo sapiens	59-64
7918682-3	1994	For the first time we now report the occurrence of a human Lp(a) that has a mutant form of apo(a) where Arg has replaced Trp in position 72 of kringle 4-37 and is unable to bind to lysine Sepharose.	Arginine	104-107	lipoprotein(a)	Homo sapiens	91-97
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Arginine	175-178	insulin 2	Rattus norvegicus	24-33
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Arginine	175-178	insulin 2	Rattus norvegicus	206-215
7971270-1	1994	Two residues are invariant in all bZip basic regions: asparagine -18 and arginine -10 (we define the first leucine of the leucine zipper of GCN4 as +1).	Arginine	73-81	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	140-144
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Arginine	179-182	insulin 2	Rattus norvegicus	24-33
2689438-2	1989	Comparison of all known C-peptide sequences reveals the presence of a highly conserved peptide sequence, Glu/Asp-X-Glu/Asp (X being a hydrophobic amino acid), adjacent to the Arg-Arg doublet at the B chain/C-peptide junction.	Arginine	179-182	insulin 2	Rattus norvegicus	206-215
7899138-6	1994	This strong interaction is electrostatic, involving HNE/arginine residues disposed in a "cluster shoe" arrangement on the surface of the molecule and mainly OSO3- groups of heparin.	Arginine	56-64	elastase, neutrophil expressed	Homo sapiens	52-55
2669815-2	1989	For example, the P21 proteins with Arg 12 or Val 13 are both known to be actively transforming.	Arginine	35-38	H3 histone pseudogene 16	Homo sapiens	17-20
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	163-171	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	142-146
8083346-6	1994	The COOH-terminal 32-residue peptide of cloned hamster preproBNP with 122 amino acids, preceded by a single arginine residue, supposedly represents hamster BNP showing &lt; 50% homology to rat BNP.	Arginine	108-116	natriuretic peptide B	Homo sapiens	61-64
2707281-0	1989	Ornithine transcarbamylase deficiency in a male: strict correlation between metabolic control and plasma arginine concentration.	Arginine	105-113	ornithine transcarbamylase	Homo sapiens	0-26
2707281-1	1989	In a male with a partial defect of ornithine transcarbamylase (OTC) we observed that maintenance of arginine supply was crucial for adequate metabolic control in conjunction with a low protein diet.	Arginine	100-108	ornithine transcarbamylase	Homo sapiens	35-61
2707281-1	1989	In a male with a partial defect of ornithine transcarbamylase (OTC) we observed that maintenance of arginine supply was crucial for adequate metabolic control in conjunction with a low protein diet.	Arginine	100-108	ornithine transcarbamylase	Homo sapiens	63-66
8062839-3	1994	The cDNA (GBP1) sequence predicts a protein product (Gbp1p) that includes two domains with extensive homology to RNA recognition motifs (RRMs) and a region rich in glycine, alanine and arginine.	Arginine	185-193	uncharacterized protein	Chlamydomonas reinhardtii	10-14
8062839-3	1994	The cDNA (GBP1) sequence predicts a protein product (Gbp1p) that includes two domains with extensive homology to RNA recognition motifs (RRMs) and a region rich in glycine, alanine and arginine.	Arginine	185-193	uncharacterized protein	Chlamydomonas reinhardtii	53-58
2608278-3	1989	This mutation, which substitutes a threonine residue (wild-type) for an arginine residue (mutant), is located within the amino-terminal part of v-myb in the DNA-binding domain at a position which is conserved between the c-myb genes of chicken, humans, mice and Drosophila.	Arginine	72-80	MYB proto-oncogene, transcription factor	Homo sapiens	146-149
2608278-3	1989	This mutation, which substitutes a threonine residue (wild-type) for an arginine residue (mutant), is located within the amino-terminal part of v-myb in the DNA-binding domain at a position which is conserved between the c-myb genes of chicken, humans, mice and Drosophila.	Arginine	72-80	MYB proto-oncogene, transcription factor	Gallus gallus	221-226
8030261-3	1994	Site-directed mutagenesis of the cleavage site indicated that the arginine in position -4 is critical for HA activation by furin.	Arginine	66-74	furin, paired basic amino acid cleaving enzyme	Homo sapiens	123-128
7518445-1	1994	PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets.	Arginine	63-66	dual specificity phosphatase 2	Homo sapiens	0-4
2789519-1	1989	Argininosuccinate lyase (EC 4.3.2.1) is an enzyme of arginine biosynthesis and is also involved in the urea cycle in the liver of ureotelic animals.	Arginine	53-61	delta-1 crystallin	Gallus gallus	0-23
7518445-2	1994	The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues 100A-C in H-CDR3.	Arginine	140-143	dual specificity phosphatase 2	Homo sapiens	33-37
7518445-2	1994	The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues 100A-C in H-CDR3.	Arginine	140-143	CDR3	Homo sapiens	176-180
7518445-8	1994	Conversion of Asp100C to Glu by site-directed mutagenesis rendered the antibody inactive, indicating that the Arg-Tyr-Asp sequence in H-CDR3 is essential for PAC1 recognition of alpha IIb beta 3.	Arginine	110-113	CDR3	Homo sapiens	136-140
7518445-8	1994	Conversion of Asp100C to Glu by site-directed mutagenesis rendered the antibody inactive, indicating that the Arg-Tyr-Asp sequence in H-CDR3 is essential for PAC1 recognition of alpha IIb beta 3.	Arginine	110-113	dual specificity phosphatase 2	Homo sapiens	158-162
2516316-7	1989	A second class of GTPase inhibiting mutations in alpha s occurs in the codon for an Arg residue whose covalent modification by cholera toxin also inhibits GTP hydrolysis by alpha s. This Arg residue is located in a domain of alpha s not represented in EF-Tu or p21ras.	Arginine	84-87	HRas proto-oncogene, GTPase	Homo sapiens	261-267
2516316-7	1989	A second class of GTPase inhibiting mutations in alpha s occurs in the codon for an Arg residue whose covalent modification by cholera toxin also inhibits GTP hydrolysis by alpha s. This Arg residue is located in a domain of alpha s not represented in EF-Tu or p21ras.	Arginine	187-190	HRas proto-oncogene, GTPase	Homo sapiens	261-267
8027220-4	1994	Analysis of her P450c17 gene by polymerase chain reaction amplification and direct sequencing showed mutation of codon 440 from CGC (Arg) to CAC (His).	Arginine	133-136	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-23
3066243-6	1988	A synthetic peptide Gly-Arg-Gly-Asp-Ser, representing the host cell attachment site of fibronectin, partially inhibited the binding of fibronectin and of its 210 kD fragment to S dysgalactiae, but not to S equi.	Arginine	24-27	fibronectin 1	Bos taurus	135-146
8003494-4	1994	The four arginines present on ubiquitin at positions 42, 54, 72, and 74 were independently mutated to leucine and their effects on the interaction of the resulting polypeptides with ubiquitin-activating enzyme (E1) were characterized.	Arginine	9-18	ubiquitin like modifier activating enzyme 7	Homo sapiens	182-214
8206928-0	1994	Internalization of the constitutively active arginine 1152--&gt;glutamine insulin receptor occurs independently of insulin at an accelerated rate.	Arginine	45-53	insulin receptor	Homo sapiens	74-90
2460086-4	1988	Reaction of I alpha I with the arginine-modifying reagent butane-2,3-dione afforded partial loss of inhibitory activity against both cathepsin G and elastase but complete loss of activity against trypsin and chymotrypsin.	Arginine	31-39	cathepsin G	Homo sapiens	133-157
8033372-13	1994	CONCLUSION: Our results show that beta 2-adrenergic activation by salbutamol is able to inhibit not only the GH rise induced by GHRH, arginine and pyridostigmine, but even the potentiating effect of both arginine and pyridostigmine on the GH response to GHRH.	Arginine	134-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-40
2460086-7	1988	These findings suggest that both cathepsin G and elastase are inhibited at either of the reactive centres of I alpha I. Trypsin and chymotrypsin, however, appear to be inhibited exclusively at the arginine reactive centre.	Arginine	197-205	cathepsin G	Homo sapiens	33-57
8033372-13	1994	CONCLUSION: Our results show that beta 2-adrenergic activation by salbutamol is able to inhibit not only the GH rise induced by GHRH, arginine and pyridostigmine, but even the potentiating effect of both arginine and pyridostigmine on the GH response to GHRH.	Arginine	204-212	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-40
2455726-8	1988	This "catch-up" was counteracted by a peptide that contained the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser).	Arginine	106-109	fibronectin 1	Rattus norvegicus	93-104
8189547-1	1994	Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease recognition (for reviews, see P. J. Barr, Cell 66:1-3, 1991, and Y. Nagai, Trends Microbiol.	Arginine	262-265	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8189547-1	1994	Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease recognition (for reviews, see P. J. Barr, Cell 66:1-3, 1991, and Y. Nagai, Trends Microbiol.	Arginine	272-275	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
2847349-6	1988	Modification of arginine residues with Phenylglyoxal and 2,3,Butanedione led to loss of thrombomodulin binding affinity.	Arginine	16-24	thrombomodulin	Homo sapiens	88-102
2847349-9	1988	These results indicate that one or more tryptophan, arginine and tyrosine residues are essential for the recognition of thrombin by thrombomodulin whilst the carbohydrate side chain and the active site residues of the thrombin molecule are not involved in thrombomodulin binding.	Arginine	52-60	thrombomodulin	Homo sapiens	132-146
8189547-1	1994	Furin, a subtilisin-like mammalian endoprotease, is thought to be responsible for the processing of many proprotein precursors of cellular and viral origin, including gp160 of human immunodeficiency virus type 1, which share the consensus processing site motif, Arg-X-Lys/Arg-Arg, for protease recognition (for reviews, see P. J. Barr, Cell 66:1-3, 1991, and Y. Nagai, Trends Microbiol.	Arginine	272-275	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Arginine	124-127	coagulation factor VIII	Homo sapiens	70-81
3285324-5	1988	The tDNA(Arg)-tDNA(SUP)6-o was transcribed into a dimeric precursor which was processed to mature tRNA molecules as judged in vitro by electrophoretic separation, and in vivo by their ability to suppress ochre but not amber yeast mutations.	Arginine	9-12	SUP6	Saccharomyces cerevisiae S288C	19-24
8043104-2	1994	ArgRIIIp (Arg82p), together with ArgRIp (Arg80p), ArgRIIp (Arg81p) and Mcm1p, regulates the expression of arginine anabolic and catabolic genes.	Arginine	106-114	Arg81p	Saccharomyces cerevisiae S288C	59-65
2966181-3	1988	Adhesion to fibronectin does not require platelet activation and is inhibited by soluble fibronectin, antibodies specific for fibronectin, peptides containing the sequence Arg-Gly-Asp and polyclonal antibodies specific for band 3 of the chicken embryo fibroblast fibronectin receptor (anti-band 3).	Arginine	172-175	fibronectin 1	Gallus gallus	12-23
8067751-1	1994	The mutation of Arg-244 to Ser (Arg-244--&gt;Ser mutation) in the TEM-1 beta-lactamase has been shown to produce resistance to inactivation by clavulanate in the mutant enzyme and resistance to ampicillin plus clavulanate in a strain of Escherichia coli producing this enzyme.	Arginine	16-19	TEM-1 beta-lactamase	Escherichia coli	66-86
3126813-2	1988	Both hFSH-beta and mEGF contain the tetrapeptide sequence Thr-Arg-Asp-Leu (TRDL).	Arginine	62-65	follicle stimulating hormone subunit beta	Homo sapiens	5-14
8067751-2	1994	The Arg-164--&gt;Ser mutation in the TEM-1 beta-lactamase (TEM-12 enzyme) is known to enhance the activity of the enzyme against ceftazidime, resulting in resistance to the drug in a strain producing the mutant enzyme (D. A. Weber, C. C. Sanders, J. S. Bakken, and J. P. Quinn, J. Infect.	Arginine	4-7	TEM-1 beta-lactamase	Escherichia coli	37-57
8067751-7	1994	Thus, the Arg-164--&gt;Ser mutation in the TEM-1 beta-lactamase suppresses the effect of the Arg-244--&gt;Ser mutation which, by itself, reduces the sensitivity of the enzyme to inactivation by clavulanate.	Arginine	10-13	TEM-1 beta-lactamase	Escherichia coli	43-63
2908810-5	1988	The Arg residue of the LSKs is critical for cockroach hindgut contractile stimulatory activity, as its introduction into gastrin II transforms the inactive peptide into an active analog.	Arginine	4-7	gastrin	Homo sapiens	121-128
8067751-7	1994	Thus, the Arg-164--&gt;Ser mutation in the TEM-1 beta-lactamase suppresses the effect of the Arg-244--&gt;Ser mutation which, by itself, reduces the sensitivity of the enzyme to inactivation by clavulanate.	Arginine	93-96	TEM-1 beta-lactamase	Escherichia coli	43-63
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Arginine	125-133	pappalysin 1	Homo sapiens	53-57
3693353-10	1987	Amino acid sequencing of the purified tryptic phosphopeptide revealed that this threonine residue lies within the sequence: Ala-Gly-Glu-Thr-Arg-Phe-Thr-Asp-Thr-Arg (residues 51-60 of EF-2).	Arginine	160-163	eukaryotic translation elongation factor 2	Homo sapiens	183-187
8139542-6	1994	This conclusion was further supported by the finding that inserting the mRNA segment encoding the leader peptide sequence of CPA1 in the leader sequence of another gene, namely, GCN4, places this gene under arginine repression.	Arginine	207-215	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	178-182
8183282-3	1994	Genotype analysis revealed that individuals with two DQB1 alleles having a non-aspartic residue in position 57 and two DQA1 alleles with an arginine residue in position 52 had the highest relative risk of disease: they constituted 41% of IDDM patients as compared to 0% of controls.	Arginine	140-148	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	119-123
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Arginine	119-122	fibronectin 1	Mus musculus	15-26
2958379-4	1987	In the case of fibronectin, the rate of outgrowth in the presence of the heparin is slower than in the presence of the Arg-Gly-Asp-Ser-containing peptide that is recognized by a fibronectin receptor.	Arginine	119-122	fibronectin 1	Mus musculus	178-189
2820790-6	1987	These results indicate that arginine residues play a critical role in maintaining the GABA receptor in a conformation capable of ligand binding, possibly by participating in the binding site through interaction with the carboxylate moiety of GABA.	Arginine	28-36	GABA type A receptor-associated protein	Homo sapiens	86-99
7510883-3	1994	Nitric oxide is derived from L-arginine by isoforms of nitric-oxide synthase (NOS; EC 1.14.13.39): constitutive (cNOS; calcium-dependent) and inducible (iNOS; calcium-independent).	Arginine	29-39	nitric oxide synthase 1, neuronal	Mus musculus	55-76
3126836-2	1987	The cleavage occurs at a unique position of the protein chain, namely at arginine-68 of Artemia EF-1 alpha.	Arginine	73-81	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	96-106
8137920-4	1994	However, by changing the dibasic cleavage site positioned N-terminal to the VIP sequence in the precursor into the consensus sequence (Arg, X,Lys/Arg,Arg) for the ubiquitous processing enzyme furin, thought to process, e.g. insulin receptors, factor VII, and by deleting residues 156-170 in the VIP precursor, expression of amidated VIP was obtained in this fibroblast cell line.	Arginine	135-138	furin (paired basic amino acid cleaving enzyme)	Mus musculus	192-197
8117736-2	1994	Tat uses a single arginine residue within a short region of basic amino acids to recognize a bulge region in TAR.	Arginine	18-26	tyrosine aminotransferase	Homo sapiens	0-3
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	GRDX	Homo sapiens	32-35
8122109-3	1994	A ts derivative of Arg-DHFR was identified that is long-lived at 23 degrees C but rapidly degraded by the N-end rule pathway at 37 degrees C. Fusions of ts Arg-DHFR to either Ura3 or Cdc28 of S. cerevisiae confer ts phenotypes specific for these gene products.	Arginine	19-22	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	175-179
3497920-1	1987	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-ethyl ester, having the amino acid sequence around the SH1 of myosin heavy chain, was coprecipitated with F-actin after ultracentrifugation.	Arginine	21-24	myosin heavy chain 14	Homo sapiens	107-113
3497920-1	1987	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-ethyl ester, having the amino acid sequence around the SH1 of myosin heavy chain, was coprecipitated with F-actin after ultracentrifugation.	Arginine	33-36	myosin heavy chain 14	Homo sapiens	107-113
3113947-4	1987	Evidence was obtained that arginine and lysine were released from the C terminus of the pentapeptide before amidation took place since the rate of formation of dipeptide amide was reduced at pH values that were compatible with amidation but unfavourable to the action of carboxypeptidase H.	Arginine	27-35	carboxypeptidase E	Homo sapiens	271-289
8122109-3	1994	A ts derivative of Arg-DHFR was identified that is long-lived at 23 degrees C but rapidly degraded by the N-end rule pathway at 37 degrees C. Fusions of ts Arg-DHFR to either Ura3 or Cdc28 of S. cerevisiae confer ts phenotypes specific for these gene products.	Arginine	156-159	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	175-179
8015389-2	1994	At this site, GluR-B subunits contain an arginine while other AMPA receptor subunits contain glutamine.	Arginine	41-49	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	14-20
3304168-11	1987	Using the peptidyl 7-amino-4-methylcoumarin (NHMec) substrates (Z-Arg-Arg-NHMec, for cathepsin B; Arg-NHMec for cathepsin H; and Z-Phe-Phe-CHN2-inhibitable hydrolysis of Z-Phe-Arg-NHMec corrected for inhibition of cathepsin B activity for cathepsin L) values obtained were (means +/- SE, mU/mg protein, 1 mU = production of 1 nM product/min, n = 6): cathepsin B, 2.1 +/- 0.34; cathepsin H, 1.35 +/- 0.19; cathepsin L, 14.49 +/- 1.26.	Arginine	66-69	cathepsin B	Rattus norvegicus	85-96
8015389-4	1994	The appearance of arginine and not glutamine in the mature GluR-B protein is thought to be a result of RNA editing of the GluR-B messenger RNA.	Arginine	18-26	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	59-65
2956270-2	1987	Whereas the Ba F3 cell line, which has both immunoglobulin heavy- and light-chain genes in germline configuration, interacts with the arg-gly-asp-containing cell-binding domain of fibronectin, the B-committed line PD 31, which is undergoing rearrangement of immunoglobulin light-chain genes, does not.	Arginine	134-137	fibronectin 1	Mus musculus	180-191
8015389-4	1994	The appearance of arginine and not glutamine in the mature GluR-B protein is thought to be a result of RNA editing of the GluR-B messenger RNA.	Arginine	18-26	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	122-128
8156733-2	1994	The present study was designed to explore the role of NO derived from L-arginine in the vasodilatory response to synthetic human parathyroid hormone-related peptide-(1-34) in the isolated rabbit kidney perfused in the presence of indomethacin (10 mumol/l) and preconstricted with noradrenaline (7.2 nmol/min).	Arginine	70-80	parathyroid hormone like hormone	Homo sapiens	129-164
8156733-11	1994	Both L-arginine and N-alpha-benzoyl-L-arginine ethyl ester effectively reversed the inhibition induced by NG-nitro-L-arginine methyl ester on the vasodilatation elicited by acetylcholine and parathyroid hormone-related peptide.	Arginine	5-15	parathyroid hormone like hormone	Homo sapiens	191-226
3496414-7	1987	A perfect match between amino acid residues 347-376 in this Arg-Serpin and the published sequence of a 30-residue, tryptic peptide from the COOH-terminus of a monocyte plasminogen activator-inhibitor (PAI-2), strongly suggests that the Arg-Serpin encoded by pcD-1214 is PAI-2.	Arginine	236-239	serpin family B member 2	Homo sapiens	201-206
8156733-13	1994	In conclusion, the formation of NO from L-arginine contributes a substantial part to the vasodilatory action of parathyroid hormone-related peptide.	Arginine	40-50	parathyroid hormone like hormone	Homo sapiens	112-147
8012360-0	1994	Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms.	Arginine	50-58	coproporphyrinogen oxidase	Homo sapiens	90-116
3035212-7	1987	At position 12 in the p21 coding region, arginine is substituted for the naturally occurring glycine present in c-ras.	Arginine	41-49	H3 histone pseudogene 16	Homo sapiens	22-25
3555844-1	1987	The expression of gene CPA1, encoding the glutaminase subunit of the arginine pathway carbamoyl-phosphate synthetase, is repressed by arginine at a posttranscriptional level.	Arginine	69-77	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	23-27
7520037-3	1994	When assayed in the requisite presence of L-arginine, CaCl2, NADPH, calmodulin, tetrahydro-L-biopterin, and FAD, the purified enzyme exhibited a specific activity of 328 nmol/min/mg L-citrulline formed and an apparent Km for L-arginine of 2.9 microM.	Arginine	42-52	calmodulin 1	Rattus norvegicus	68-78
7520037-3	1994	When assayed in the requisite presence of L-arginine, CaCl2, NADPH, calmodulin, tetrahydro-L-biopterin, and FAD, the purified enzyme exhibited a specific activity of 328 nmol/min/mg L-citrulline formed and an apparent Km for L-arginine of 2.9 microM.	Arginine	225-235	calmodulin 1	Rattus norvegicus	68-78
3555844-4	1987	The results show that the leader peptide, the product of the upstream open reading frame, plays an essential, negative role in the specific repression of CPA1 by arginine.	Arginine	162-170	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	154-158
8077255-1	1994	The adhesive interaction of cells with extracellular matrix components is essential for a variety of cellular functions, and is frequently mediated by a tetra peptide, Arg-Gly-Asp-Ser (RGDS), located within fibronectin and other proteins.	Arginine	168-171	ral guanine nucleotide dissociation stimulator	Homo sapiens	185-189
8120401-2	1994	We have now extended this model by introducing an arginine into the CDR2 of the heavy chain transgene.	Arginine	50-58	cerebellar degeneration-related 2	Mus musculus	68-72
3304435-3	1987	Subsequently, the total arginine amidolytic activity of the spermatozoa was determined spectrophotometrically after a combined treatment that resulted in extraction, proacrosin activation, and reaction with substrate.	Arginine	24-32	acrosin	Homo sapiens	166-176
7509263-1	1994	Nitric oxide (NO) is generated intracellularly from L-arginine by the action of the enzyme nitric oxide synthase (NOS).	Arginine	52-62	nitric oxide synthase 1, neuronal	Mus musculus	91-112
3295876-7	1987	Presence of OTCase enzymatic activity in an arg3 strain expressing wild-type precursor was utilized to obtain selective growth in a medium devoid of arginine but supplemented with the OTCase substrate ornithine.	Arginine	149-157	ornithine transcarbamylase	Homo sapiens	12-18
3295876-7	1987	Presence of OTCase enzymatic activity in an arg3 strain expressing wild-type precursor was utilized to obtain selective growth in a medium devoid of arginine but supplemented with the OTCase substrate ornithine.	Arginine	149-157	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	44-48
8307627-10	1994	The hypertension is accompanied by increases in plasma renin activity and can be prevented with intravenous L-arginine administration.	Arginine	108-118	renin	Rattus norvegicus	55-60
3495295-2	1987	Substrates based on the C-terminal sequence of human C4a (Leu-Gln-Arg) were synthesised.	Arginine	66-69	complement C4A (Rodgers blood group)	Homo sapiens	53-56
3603738-0	1987	[Antithrombin activity of methyl esters of arginine-containing peptides].	Arginine	43-51	serpin family C member 1	Homo sapiens	1-13
8008835-7	1994	The arginine (R) found in GluR B subunits at that position renders AMPA channels impermeable for Ca2+ ions, whereas glutamine (Q) containing GluR A, C and D subunits give rise to Ca2+ permeable channels.	Arginine	4-12	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	26-32
8008835-8	1994	RNA editing converts the genomically encoded glutamine codon into the arginine codon found in GluR B cDNAs for the Q/R site.	Arginine	70-78	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	94-100
3548429-1	1987	Less than Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2, the luteinizing hormone-releasing hormone, LHRH, is degraded in renal proximal tubules (PT) in vivo (rat) and in vitro (rabbit) to less than Glu-His (2), less than Glu-His-Trp (3), and less than Glu-His-Trp-Ser (4).	Arginine	38-41	gonadotropin releasing hormone 1	Rattus norvegicus	59-96
8276107-1	1994	We made a mutated progastrin cDNA construct that contains a cleavage site (-Arg(-4)-Arg(-3)-Lys(-2)-Arg-1) specific for the Kex2-like endoprotease furin, located ahead of the bioactive gastrin.	Arginine	84-87	arginase-1	Cricetulus griseus	100-105
3497646-4	1987	C3d was shown to be generated in the artificial kidney with kinetics resembling the formation of C5a/C5ades-Arg.	Arginine	108-111	endogenous retrovirus group K member 13	Homo sapiens	0-3
3024151-5	1986	An interesting observation is the Gly-Arg-Gly-Asp-Ser sequence, which is identical to the cell-binding sequence identified in fibronectin.	Arginine	38-41	fibronectin 1	Rattus norvegicus	126-137
8032268-2	1994	The pentapeptide sequence P 648R RRV is an essential part of the nuclear localization signal (NLS) of nsP2, the middle arginine being the most critical residue for nuclear targeting.	Arginine	119-127	reticulon 2	Homo sapiens	102-106
3023389-7	1986	The synthetic peptide Gly-Arg-Gly-Asp-Ser derived from the sequence of the cell-binding region of fibronectin could also prevent the organization of fibronectin-140K linkage complexes.	Arginine	26-29	fibronectin 1	Gallus gallus	98-109
7704558-0	1994	Frequent constitutional C to T mutations in CGA-arginine codons in the RB1 gene produce premature stop codons in patients with bilateral (hereditary) retinoblastoma.	Arginine	48-56	RB transcriptional corepressor 1	Homo sapiens	71-74
3023389-7	1986	The synthetic peptide Gly-Arg-Gly-Asp-Ser derived from the sequence of the cell-binding region of fibronectin could also prevent the organization of fibronectin-140K linkage complexes.	Arginine	26-29	fibronectin 1	Gallus gallus	149-160
8263031-10	1994	Adding the synthetic peptide, arg-gly-asp-ser (RGDS) to the medium, blocked migration on fibronectin-coated implants but had no effect on implants coated with type IV, suggesting that migration on type IV involves different cell surface receptors than those mediating migration over fibronectin.	Arginine	30-33	ral guanine nucleotide dissociation stimulator	Homo sapiens	47-51
3028371-1	1986	We have prepared a semisynthetic analogue of fully acetimidylated horse cytochrome c, a complex in which the peptide bond between residues glycine-37 and arginine-38 is lacking.	Arginine	154-162	cytochrome c, somatic	Equus caballus	72-84
8262986-10	1993	This serous cell lysozyme is predicted to differ importantly in structure from both 7a and 14d lysozymes, with an arginine:lysine ratio almost 10-fold higher.	Arginine	114-122	lysozyme C, tracheal isozyme	Bos taurus	17-25
3489715-3	1986	Proton NMR studies indicate that the overall structure of mouse epidermal growth factor is retained in the protein devoid of the COOH-terminal pentapeptide, while subsequent cleavage of the peptide bond between Arg-45 and Asp-46 starts to perturb the proton resonances most characteristic of the tertiary structure of the hormone, especially those from the aromatic ring protons of Tyr-37.	Arginine	211-214	epidermal growth factor	Mus musculus	64-87
7925478-3	1993	An increased rate of actin polymerization was found in "aggregating" conditions as compared to "activating" conditions, the latter achieved by either absence of stirring or stirring in the presence of the tetrapeptide Arg-Gly-Asp-Ser (RGDS).	Arginine	218-221	ral guanine nucleotide dissociation stimulator	Homo sapiens	235-239
3539098-6	1986	The histidine and arginine residues implicated as being important for the activity of yeast enolase are conserved in the chicken enzyme.	Arginine	18-26	enolase 3 (beta, muscle)	Gallus gallus	92-99
8155258-4	1993	The CDR3 sequences for both the antibodies had a predominance of basic amino acids, with RT-79 having five and D-5 two arginine residues respectively.	Arginine	119-127	CDR3	Homo sapiens	4-8
2422647-1	1986	The complete amino acid sequence of the prostate-specific antigen (PA) from human seminal plasma has been determined from analyses of the peptides generated by cyanogen bromide, hydroxylamine, endoproteinases Arg-C and Lys-C.	Arginine	209-212	kallikrein related peptidase 3	Homo sapiens	40-70
2422647-7	1986	The cleavage sites of these proteins by PA were chemically analyzed as the alpha-carboxyl side of some hydrophobic residues, tyrosine, leucine, valine, and phenylalanine, and of basic residues histidine, lysine, and arginine.	Arginine	216-224	kallikrein related peptidase 3	Homo sapiens	40-42
8155258-8	1993	Comparisons of Ig variable regions indicate that the amino acids in the CDR3 region of the mu chain influence the ability of IgM encoded by the VH4-21 gene segment to discriminate between a carbohydrate Ii antigen and DNA, and strongly support the suggested role of arginine in interaction with DNA.	Arginine	266-274	CDR3	Homo sapiens	72-76
8304052-1	1993	The bone sialoprotein osteopontin (OPN) promotes cell attachment and spreading through its RGD (Arg-Gly-Asp) sequence.	Arginine	96-99	secreted phosphoprotein 1	Rattus norvegicus	22-33
3486005-4	1986	Chemical modification of arginine and histidine residues on C1q as well as pretreatment of C1q at pH 4.45 or at 56 degrees C reduced its spectrin binding activity.	Arginine	25-33	complement C1q A chain	Homo sapiens	60-63
8304052-1	1993	The bone sialoprotein osteopontin (OPN) promotes cell attachment and spreading through its RGD (Arg-Gly-Asp) sequence.	Arginine	96-99	secreted phosphoprotein 1	Rattus norvegicus	35-38
8167407-1	1993	Nucleolin (713 aa), a major nucleolar protein, presents two structural domains: a N-terminus implicated in interaction with chromatin and a C-terminus containing four RNA-binding domains (RRMs) and a glycine/arginine-rich domain mainly involved in pre-rRNA packaging.	Arginine	208-216	nucleolin	Homo sapiens	0-9
3082364-1	1986	The contribution of lysine and arginine residues to the substrate specificity of the myosin light-chain kinase has been studied using chemically modified myosin light chains.	Arginine	31-39	myosin light chain kinase	Homo sapiens	85-110
3082364-1	1986	The contribution of lysine and arginine residues to the substrate specificity of the myosin light-chain kinase has been studied using chemically modified myosin light chains.	Arginine	31-39	myosin heavy chain 14	Homo sapiens	85-91
3082364-8	1986	The results of this study support the concept that lysine and arginine residues act as essential specificity determinants for the myosin light-chain kinase in protein substrates.	Arginine	62-70	myosin light chain kinase	Homo sapiens	130-155
8232556-6	1993	A lysine to arginine substitution at the corresponding residue of BRG1 also generated a transcriptional dominant negative in human cells.	Arginine	12-20	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	66-70
3512287-1	1986	The release of insulin which occurred in response to arginine, in the conscious calf, differed from that which occurs in response to glucose in that it was not significantly affected by either adrenergic or muscarinic blocking agents.	Arginine	53-61	insulin	Bos taurus	15-22
8218226-2	1993	A ubiquitously expressed calcium-dependent subtilisin-like serine protease, named PACE or furin, can cleave precursor polypeptides specifically at pairs of basic amino acids where an arginine residue is present in the P4 position.	Arginine	183-191	furin, paired basic amino acid cleaving enzyme	Homo sapiens	82-86
8218226-2	1993	A ubiquitously expressed calcium-dependent subtilisin-like serine protease, named PACE or furin, can cleave precursor polypeptides specifically at pairs of basic amino acids where an arginine residue is present in the P4 position.	Arginine	183-191	furin, paired basic amino acid cleaving enzyme	Homo sapiens	90-95
7690548-1	1993	Furin has been proposed to be the endoprotease responsible for precursor cleavage at Arg-X-Lys/Arg-Arg (RXK/RR) sites within the constitutive secretory pathway.	Arginine	85-88	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	56-59	serpin family C member 1	Homo sapiens	66-72
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	124-132	serpin family C member 1	Homo sapiens	66-72
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	134-137	serpin family C member 1	Homo sapiens	66-72
7690548-1	1993	Furin has been proposed to be the endoprotease responsible for precursor cleavage at Arg-X-Lys/Arg-Arg (RXK/RR) sites within the constitutive secretory pathway.	Arginine	95-98	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7690548-1	1993	Furin has been proposed to be the endoprotease responsible for precursor cleavage at Arg-X-Lys/Arg-Arg (RXK/RR) sites within the constitutive secretory pathway.	Arginine	95-98	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8239537-5	1993	A CGA to TGA nonsense mutation at codon 390 with arginine being substituted with a stop codon was detected and predicted to encode a faulty WT1 protein in this WT, out of 8 WTs studied.	Arginine	49-57	T-box transcription factor 1	Homo sapiens	9-12
4091829-0	1985	Chemical modification of arginine residues of lung galaptin and fibronectin.	Arginine	25-33	galectin 1	Homo sapiens	51-59
4091829-3	1985	Selective modifications of the arginine residues of galaptin with cyclohexane-1,2-dione did not change its lectin activity or its binding to fibroblasts.	Arginine	31-39	galectin 1	Homo sapiens	52-60
8325838-3	1993	We demonstrate using flow cytometric methods a central role for the beta 3 integrin glycoprotein (GP) IIb-IIIa complex and its ligand tetrapeptide Arg-Gly-Asp-Ser (RGDS) binding site in platelet vesiculation.	Arginine	147-150	ral guanine nucleotide dissociation stimulator	Homo sapiens	164-168
3915770-0	1985	General amino acid control and specific arginine repression in Saccharomyces cerevisiae: physical study of the bifunctional regulatory region of the ARG3 gene.	Arginine	40-48	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	149-153
3915770-1	1985	To characterize further the regulatory mechanism modulating the expression of the Saccharomyces cerevisiae ARG3 gene, i.e., the specific repression by arginine and the general amino acid control, we analyzed by deletion the region upstream of that gene, determined the nucleotide sequence of operator-constitutive-like mutations affecting the specific regulation, and examined the behavior of an ARG3-galK fusion engineered at the initiating codon of ARG3.	Arginine	151-159	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	107-111
8323289-0	1993	Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase.	Arginine	19-27	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	51-55
3001041-4	1985	There were 11 lysines and 6 arginines in Ch1, whereas there were 6 lysines and 11 arginines in Ch2.	Arginine	82-91	acylphosphatase 1	Gallus gallus	95-98
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Arginine	89-97	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
3906217-0	1985	Secretory responses of insulin, glucagon and 11-hydroxycorticosteroids to arginine injection in calves exposed to heat.	Arginine	74-82	insulin	Bos taurus	23-30
8323289-1	1993	Chemical modification of cytochrome P450 was used to study the involvement of lysine and arginine residues in the interaction between cytochrome P450 and NADPH-cytochrome P450 reductase.	Arginine	89-97	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	145-149
8019886-7	1993	DQA1*01 group of alleles (DQA1*0101, 0102 or 0103 allele) encode DQ alpha chains sharing long polymorphic sequence including non-charged glycine and positively charged arginine residues at positions 55 and 64, respectively.	Arginine	168-176	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	0-4
8019886-7	1993	DQA1*01 group of alleles (DQA1*0101, 0102 or 0103 allele) encode DQ alpha chains sharing long polymorphic sequence including non-charged glycine and positively charged arginine residues at positions 55 and 64, respectively.	Arginine	168-176	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	26-30
8507640-0	1993	Structural and functional characterization of sperm whale myoglobin mutants: role of arginine (E10) in ligand stabilization.	Arginine	85-93	myoglobin	Physeter catodon	58-67
4030139-7	1985	The amino acid sequence of rabbit TNF was determined as Ser-Ala-Ser-Arg-Ala-Leu- ....	Arginine	68-71	tumor necrosis factor	Oryctolagus cuniculus	34-37
8507640-2	1993	Arg(E10) was previously found to form a hydrogen bond with the ligand in fluoro-, azido- and cyanomet derivatives of Aplysia limacina myoglobin, which lacks the distal His(E7) [Qin, J., La Mar, G. N., Ascoli, F., Bolognesi, M., &amp; Brunori, M. (1992) J. Mol.	Arginine	0-3	myoglobin	Physeter catodon	134-143
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Arginine	215-218	epidermal growth factor	Mus musculus	135-158
4054942-2	1985	The product was covalently coupled to a nonimmunogenic oligopeptide, representing an extracytoplasmic sequence of the receptor for the epidermal growth factor (EGF-R amino acids 516-529: Asn-Leu-Leu-Glu-Gly-Glu-Pro-Arg-Glu-Phe-Val-Glu-Asn-Ser).	Arginine	215-218	epidermal growth factor receptor	Mus musculus	160-165
8507640-5	1993	NMR analysis of the paramagnetically induced relaxation, hyperfine shift patterns, and dipolar connectivities shows that Arg(E10) also falls into the distal pocket in the engineered sperm whale myoglobin mutants and resides at an H-bonding distance from the Fe(3+)-bound cyanide.	Arginine	121-124	myoglobin	Physeter catodon	194-203
8509361-4	1993	Although the severity of both NARP and SNE disease were correlated with the quantity of the ATPase 6leu156--&gt;arg mutation in each patient, the mutation could not be shown to alter F1F0-ATP synthase activity.	Arginine	112-115	mitochondrially encoded ATP synthase 6	Homo sapiens	92-100
3839563-11	1985	The three emtB mutations analyzed affect two adjacent arginine codons within the very basic S14 carboxyl region, indicating a significant role for this portion of the protein in the function and architecture of the mammalian 40S ribosomal subunit.	Arginine	54-62	ribosomal protein S14	Homo sapiens	10-14
8388303-0	1993	L-arginine exerts a dual role in nociceptive processing in the brain: involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway.	Arginine	0-10	5'-nucleotidase, cytosolic II	Mus musculus	137-140
2993267-6	1985	CANP cleaved the clupeine YII and Z components at two sites, both being arginyl-arginine bonds, and the amino acid sequences around these sites were almost identical between YII and Z.	Arginine	80-88	calpain 1	Homo sapiens	0-4
8388303-20	1993	These findings suggest that L-Arg plays a dual role in nociceptive processing in the brain, being antinociceptive via the kyotorphin-Met-enkephalin pathway and nociceptive via the NO-cyclic GMP pathway.	Arginine	28-33	5'-nucleotidase, cytosolic II	Mus musculus	190-193
8387226-4	1993	CDR3s of NE-1 and NE-13 heavy chains were arginine rich and CDR1s contained an amino acid stretch, SGYY, the inverted sequence of YYGS, which was shared among CDR3s of several anti-DNA antibodies.	Arginine	42-50	CDR3	Homo sapiens	0-4
3988798-0	1985	Expression of amplified DNA sequences for ornithine transcarbamylase in HeLa cells: arginine residues may be required for mitochondrial import of enzyme precursor.	Arginine	84-92	ornithine transcarbamylase	Homo sapiens	42-68
3988798-8	1985	When a HeLa transformant was incubated with the arginine analogue canavanine, the major form of newly synthesized OTC detected was a species migrating slightly more slowly than the normal precursor; little mature-sized subunit was recovered.	Arginine	48-56	ornithine transcarbamylase	Homo sapiens	114-117
7683726-13	1993	The region defined by these suppressors is dynamically linked to the Arg cluster through the function of the AAC2 protein.	Arginine	69-72	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	109-113
3988798-9	1985	This indicates that substitution of the analogue for arginine in the OTC precursor interferes with mitochondrial import and processing.	Arginine	53-61	ornithine transcarbamylase	Homo sapiens	69-72
3988798-10	1985	Thus, arginine residues in the OTC precursor--most likely the four residues contained in its NH2-terminal leader sequence--probably play an important role in mitochondrial import and/or processing.	Arginine	6-14	ornithine transcarbamylase	Homo sapiens	31-34
8476414-4	1993	This mutation which changes a conserved leucine to an arginine in the putative membrane proton channel of mitochondrial ATPase effectively reduces the overall rate of oxidative phosphorylation.	Arginine	54-62	ATP synthase F1 subunit epsilon	Homo sapiens	106-126
3872340-3	1985	Chemical modification of arginine residues by phenylglyoxal or sulfhydryl groups by N-ethyl maleimide and iodoacetamide completely destroys the activity of IL-1 from THP-1 cells as well as that of the pI 6.8 component from PBM.	Arginine	25-33	interleukin 1 alpha	Homo sapiens	156-160
8514733-2	1993	Cathepsin C efficiently degraded Z-Phe-Arg-MCA, Pro-Phe-Arg-MCA, and Suc-Leu-Leu-Val-Tyr-MCA.	Arginine	39-42	cathepsin C	Bos taurus	0-11
2984676-5	1985	Comparison of several chemical and physical properties of the 32P-labeled phosphopeptide with the primary structure of the EGF receptor suggested the identify Lys-Arg-Thr(P)-Leu-Arg.	Arginine	163-166	epidermal growth factor	Homo sapiens	123-126
2981844-4	1985	Proapo-A-II which contains 2 arginine residues could be readily differentiated from mature apo-A-II which contains no arginine.	Arginine	29-37	apolipoprotein A2	Homo sapiens	3-11
8460164-0	1993	Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation.	Arginine	12-15	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	90-116
3001768-4	1985	The large abundance of lysine and arginine residues in the DBI molecule suggest that this polypeptide functions as a precursor of a putative endocoid which regulates anxiety levels.	Arginine	34-42	diazepam binding inhibitor	Rattus norvegicus	59-62
8460164-1	1993	The origin of the fatty acid activation and formaldehyde dehydrogenase activity that distinguishes human class III alcohol dehydrogenase (alcohol:NAD+ oxidoreductase, EC 1.1.1.1) from all other alcohol dehydrogenases has been examined by site-directed mutagenesis of its Arg-115 residue.	Arginine	271-274	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	151-165
8460164-8	1993	The results strongly indicate that Arg-115 in class III alcohol dehydrogenase is a component of the binding site for activating fatty acids and is critical for the binding of S-hydroxymethylglutathione in glutathione-dependent formaldehyde dehydrogenase activity.	Arginine	35-38	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	227-253
6394628-0	1984	Arginine infusion stimulates prolactin, growth hormone, insulin, and subsequent lactation in pregnant dairy cows.	Arginine	0-8	insulin	Bos taurus	56-63
6394628-5	1984	The secretory response of prolactin, growth hormone, and insulin to daily arginine infusion during the entire prepartum period was not diminished.	Arginine	74-82	insulin	Bos taurus	57-64
6394628-7	1984	Therefore, repeated arginine infusion in late-pregnant cows dramatically increased prolactin, growth hormone, and insulin and tended to increase subsequent milk yield.	Arginine	20-28	insulin	Bos taurus	114-121
8236247-6	1993	Ten patients with IGHD (4 of group A; 3 each of groups B &amp; C) and 2 NSC showed much greater GH responses to arginine (0.5 g/kg i.v.	Arginine	112-120	immunoglobulin heavy constant delta	Homo sapiens	18-22
7678496-2	1993	Many monoclonal antibodies reactive with breast carcinomas recognise determinants located within the mucin protein core, and epitope mapping techniques have demonstrated that these antibodies bind to epitopes of three, four or five amino acids within the hydrophilic sequence, P D T R P A P. Each of these mucin core-reactive antibodies map to epitopes containing the central arginine residue.	Arginine	376-384	LOC100508689	Homo sapiens	101-106
6090207-6	1984	The apoA-II mRNA encodes for a 100 amino acid protein, preproapoA-II that has an 18 amino acid prepeptide and a 5 amino acid propeptide terminating with a basic dipeptide (Arg-Arg) at the cleavage site to mature apoA-II.	Arginine	172-175	apolipoprotein A2	Homo sapiens	4-11
6090207-6	1984	The apoA-II mRNA encodes for a 100 amino acid protein, preproapoA-II that has an 18 amino acid prepeptide and a 5 amino acid propeptide terminating with a basic dipeptide (Arg-Arg) at the cleavage site to mature apoA-II.	Arginine	172-175	apolipoprotein A2	Homo sapiens	61-68
8454570-2	1993	One of these sequences, Arg-Gly-Asp-Ser (RGDS) tetrapeptide, was shown to be transferred to a truncated form of Staphylococcal IgG-binding protein (hereafter referred to as tSPA) with retention of its cell-adhesive activity [Maeda, T. et al.	Arginine	24-27	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
6090207-6	1984	The apoA-II mRNA encodes for a 100 amino acid protein, preproapoA-II that has an 18 amino acid prepeptide and a 5 amino acid propeptide terminating with a basic dipeptide (Arg-Arg) at the cleavage site to mature apoA-II.	Arginine	176-179	apolipoprotein A2	Homo sapiens	4-11
6090207-6	1984	The apoA-II mRNA encodes for a 100 amino acid protein, preproapoA-II that has an 18 amino acid prepeptide and a 5 amino acid propeptide terminating with a basic dipeptide (Arg-Arg) at the cleavage site to mature apoA-II.	Arginine	176-179	apolipoprotein A2	Homo sapiens	61-68
7510003-4	1993	For example, human endothelin-1 (ET-1) precursor possesses a typical furin cleavage site motif (Arg-X-Lys/Arg-Arg) at the following residues: Arg32-Ser33-Lys34-Arg35 and Arg72-Ser73-Lys74-Arg75.	Arginine	96-99	furin, paired basic amino acid cleaving enzyme	Homo sapiens	69-74
6149574-6	1984	Examination of the amino acid sequences of C4a, and comparison with those of the homologous molecules C3a and C5a, shows that there is a marked difference in the distribution of basic residues near the C-terminal arginine residue which is the site of action of C1s.	Arginine	213-221	complement C4A (Rodgers blood group)	Homo sapiens	43-46
7510003-4	1993	For example, human endothelin-1 (ET-1) precursor possesses a typical furin cleavage site motif (Arg-X-Lys/Arg-Arg) at the following residues: Arg32-Ser33-Lys34-Arg35 and Arg72-Ser73-Lys74-Arg75.	Arginine	106-109	furin, paired basic amino acid cleaving enzyme	Homo sapiens	69-74
6205792-7	1984	alpha 2M from RA patients" plasma attached to a solid-phase immunoabsorbent degraded an Arg-containing tripeptide much better than did the alpha 2M from normal donors, from patients with systemic lupus erythematosus, or from those with joint inflammation of other, "non-autoimmune" origin.	Arginine	88-91	alpha-2-macroglobulin	Homo sapiens	0-8
8230355-7	1993	Perioperative supplement with arginine significantly enhanced the immune function of patients with obstructive jaundice, the mechanism being related to increased IL-2 production and IL-2R expression.	Arginine	30-38	interleukin 2 receptor subunit alpha	Homo sapiens	182-187
8474224-1	1993	Monoclonal antibodies (TB1 & TB2), which were obtained by immunization of 24 amino acids in BALB/c mice, bound specifically to the amyloid senile plaque and amyloid-angiopathic lesions of brain tissues of patients with Alzheimer"s disease (AD) or with senile dementia of Alzheimer type (SDAT), and strongly reacted with the 1st part (Asp-Ala-Glu-Phe-Arg-His-Asp) of beta-protein.	Arginine	350-353	trophoblast specific protein alpha	Mus musculus	23-26
6539129-4	1984	The addition of arginine (0.1-1.0 mM) (but not lysine or histidine) to the H35 cells in culture concomitant with TPA also led to a relative increase in putrescine biosynthesis and a decrease in ornithine decarboxylase activity compared to cultures not receiving the amino acids.	Arginine	16-24	ornithine decarboxylase 1	Rattus norvegicus	194-217
1472066-6	1992	PTHrP 1-139 lacks the carboxy-terminal arginine and histidine residues of PTHrP 1-141; these two basic amino acids could have significant effects on the biological activity of PTHrP.	Arginine	39-47	parathyroid hormone like hormone	Homo sapiens	0-5
16663552-6	1984	Difluoromethylarginine (0.01-0.1 millimolar), the enzyme-activated irreversible inhibitor of arginine decarboxylase, prevents the stress-induced putrescine rise, as well as the incorporation of label from [(14)C]arginine, with the expected accumulation of free arginine, but has no effect on the rest of the amino acid pool.	Arginine	14-22	antizyme inhibitor 2	Homo sapiens	93-115
1490962-8	1992	In addition, lungs isolated after TNF-alpha treatment showed decreased vasodilation in response to acetylcholine (10(-8)-10(-5) M) compared with control; however, vasodilation in response to L-arginine (10 mM) and nitroprusside (10(-6.3) and 10(-6) M), agents that promote NO release, was not decreased in TNF-alpha-treated lungs.	Arginine	191-201	tumor necrosis factor	Cavia porcellus	34-43
6382603-0	1984	The growth of single crystals of (L-arginine)B0 bovine insulin and their preliminary X-ray crystallographic analysis.	Arginine	33-44	insulin	Bos taurus	55-62
6382603-1	1984	The crystals of (L-Arg)B0 bovine insulin large enough for X-ray structure analysis have been grown by vapour diffusion in a buffer containing citrate, acetone and zinc chloride.	Arginine	16-22	insulin	Bos taurus	33-40
1448098-8	1992	The gene, named EGD1 (enhancer of GAL4 DNA binding), encodes a highly basic protein (21% lysine and arginine) with a predicted molecular mass of 16.5 kDa.	Arginine	100-108	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	34-38
6143754-1	1984	Glutamine synthetase from ovine brain has a critical arginine residue at the catalytic site (Powers, S. G., and Riordan, J.F.	Arginine	53-61	glutamate-ammonia ligase	Gallus gallus	0-20
6143754-15	1984	These observations are consistent with the conclusion that the NAD:arginine ADP-ribosyltransferase modifies specifically an arginine residue involved in the catalytic site of glutamine synthetase.	Arginine	67-75	glutamate-ammonia ligase	Gallus gallus	175-195
1280830-4	1992	(i) A single-chain SF/HGF resulting from the destruction of the protease cleavage site between heavy and light chain (Arg-494--&gt; Gln) was largely inactive, indicating that proteolytic cleavage is essential for acquisition of the biologically active conformation.	Arginine	118-121	hepatocyte growth factor	Homo sapiens	19-25
1454802-1	1992	The human pre-mRNA splicing factors SF2 and SC35 have similar electrophoretic mobilities, and both of them contain an N-terminal ribonucleoprotein (RNP)-type RNA-recognition motif and a C-terminal arginine/serine-rich domain.	Arginine	197-205	serine and arginine rich splicing factor 2	Homo sapiens	44-48
1445886-9	1992	The results indicate, therefore, that residues 129 and 209 play different roles in stimulating P450coh activity by cytochrome b5; Arg-129 is a key residue in the cytochrome b5-binding domain and is essential for the stimulation.	Arginine	130-133	cytochrome b5 type A (microsomal)	Mus musculus	115-128
1445886-9	1992	The results indicate, therefore, that residues 129 and 209 play different roles in stimulating P450coh activity by cytochrome b5; Arg-129 is a key residue in the cytochrome b5-binding domain and is essential for the stimulation.	Arginine	130-133	cytochrome b5 type A (microsomal)	Mus musculus	162-175
1280107-4	1992	The amounts of MeArg and Me2(sym)Arg in MBP increased as a function of the age of the brain, whereas that of Me2(asym)Arg decreased.	Arginine	17-20	myelin basic protein	Mus musculus	40-43
1280107-4	1992	The amounts of MeArg and Me2(sym)Arg in MBP increased as a function of the age of the brain, whereas that of Me2(asym)Arg decreased.	Arginine	33-36	malic enzyme 2, NAD(+)-dependent, mitochondrial	Mus musculus	25-28
1280107-4	1992	The amounts of MeArg and Me2(sym)Arg in MBP increased as a function of the age of the brain, whereas that of Me2(asym)Arg decreased.	Arginine	33-36	myelin basic protein	Mus musculus	40-43
1280107-5	1992	MBP from early-myelinating mouse brain was shown to contain a high proportion of Me2(asym)Arg, which was hardly detectable in older brain MBP.	Arginine	90-93	myelin basic protein	Mus musculus	0-3
1280107-5	1992	MBP from early-myelinating mouse brain was shown to contain a high proportion of Me2(asym)Arg, which was hardly detectable in older brain MBP.	Arginine	90-93	malic enzyme 2, NAD(+)-dependent, mitochondrial	Mus musculus	81-84
1280107-6	1992	This derivative, Me2(asym)Arg, was also absent from MBP embedded in the most compact multilamellar myelin, but was present in MBP in the least compact myelin (P3B).	Arginine	26-29	malic enzyme 2, NAD(+)-dependent, mitochondrial	Mus musculus	17-20
1280107-6	1992	This derivative, Me2(asym)Arg, was also absent from MBP embedded in the most compact multilamellar myelin, but was present in MBP in the least compact myelin (P3B).	Arginine	26-29	myelin basic protein	Mus musculus	126-129
1280107-9	1992	MBPs isolated from dysmyelinating mutant mouse brains, such as jimpy (jp/y) and quaking (qk/qk), contained a much higher level of Me2(asym)Arg relative to the other two methyl derivatives and also in comparison with those levels in the mother brain MBP.	Arginine	139-142	myelin basic protein	Mus musculus	0-3
1400206-4	1992	One of the missense mutations (comC alpha 803) is a glycine-to-arginine change, and the resulting protein exhibits a substantially faster electrophoretic mobility.	Arginine	63-71	goF mRNA metabolism modulator	Escherichia phage T4	31-41
1402389-2	1992	It was previously shown that metabolism of L-arginine at concentrations present in vitro in RPMI medium (1.14 mM) impairs the ability of m phi s to regulate pHi.	Arginine	43-53	glucose-6-phosphate isomerase 1	Mus musculus	139-142
1402389-2	1992	It was previously shown that metabolism of L-arginine at concentrations present in vitro in RPMI medium (1.14 mM) impairs the ability of m phi s to regulate pHi.	Arginine	43-53	glucose-6-phosphate isomerase 1	Mus musculus	157-160
1402389-4	1992	To investigate the potential in vivo relevance of this inhibition, m phi pHi regulation was examined following incubation with low concentrations of L-arginine that mimic the inflammatory microenvironment, in the presence or absence of lipopolysaccharide (LPS).	Arginine	149-159	glucose-6-phosphate isomerase 1	Mus musculus	73-76
1402389-7	1992	Following incubation for 2 h in the absence of LPS, the pHi recovery rate was equivalent in cells incubated with and without L-arginine.	Arginine	125-135	glucose-6-phosphate isomerase 1	Mus musculus	56-59
1402389-8	1992	Coincubation with LPS, however, resulted in marked inhibition of pHi recovery at L-arginine concentrations as low as 12.5 microM.	Arginine	81-91	glucose-6-phosphate isomerase 1	Mus musculus	65-68
1402389-12	1992	Under conditions mimicking the in vivo setting, LPS-stimulated L-arginine metabolism impairs m phi pHi regulation.	Arginine	63-73	glucose-6-phosphate isomerase 1	Mus musculus	95-98
1402389-12	1992	Under conditions mimicking the in vivo setting, LPS-stimulated L-arginine metabolism impairs m phi pHi regulation.	Arginine	63-73	glucose-6-phosphate isomerase 1	Mus musculus	99-102
1505680-4	1992	The cross-linkage between D1 and alpha-cyt b559 involves a region on D1 between the N-terminal residue and Arg-225, and is an early event in photo-induced damage to the D1 protein.	Arginine	107-110	leiomodin 1	Homo sapiens	26-38
1517241-2	1992	Following an ill-defined activation event, the Arg-Gly-Asp (RGD) recognition site of the platelet integrin, glycoprotein IIb-IIIa (alpha IIb beta 3), can bind to fluid-phase, RGD-containing protein ligands, such as fibrinogen, or to the murine monoclonal IgM, PAC-1, which contains the sequence Arg-Tyr-Asp (RYD) within the third complementarity-determining region of its heavy chain (H3).	Arginine	47-50	dual specificity phosphatase 2	Homo sapiens	260-265
1326944-4	1992	Tetrapeptide RGDS (Arg-Gly-Asp-Ser), which blocks the interaction of ligands such as fibrinogen with platelet integrin alpha IIb beta 3 (GPIIb-IIIa), inhibited only the late-phase PtdIns(3,4)P2 accumulation that was associated with added Ca2+.	Arginine	19-22	ral guanine nucleotide dissociation stimulator	Homo sapiens	13-17
1379588-4	1992	We have identified, however, three FKBP12 surface residues (Asp-37, Arg-42, and His-87) proximal to a solvent-exposed segment of bound FK506 that may be direct contacts in the calcineurin complex.	Arginine	68-71	FKBP prolyl isomerase 1A pseudogene 2	Homo sapiens	35-41
1515027-3	1992	The masu salmon sGnRH precursor was composed of a signal peptide, sGnRH and a GnRH-associated peptide (GAP) which was connected to sGnRH by a Gly-Lys-Arg sequence.	Arginine	150-153	gonadotropin releasing hormone 1	Homo sapiens	17-21
1459319-8	1992	Both diabetic groups also displayed a significant enrichment in DQA1 alleles positives for arginine at position 52 (65% of Type 1b; 76% of Type 1a; 50% of control subjects; p &lt; 0.01 and 0.001, respectively, vs controls), and in DQA1 Arg 52 positive homozygotes (48% of Type 1b, 58% of Type 1a, 22% of control subjects; p &lt; 0.01).	Arginine	91-99	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	64-68
1459319-8	1992	Both diabetic groups also displayed a significant enrichment in DQA1 alleles positives for arginine at position 52 (65% of Type 1b; 76% of Type 1a; 50% of control subjects; p &lt; 0.01 and 0.001, respectively, vs controls), and in DQA1 Arg 52 positive homozygotes (48% of Type 1b, 58% of Type 1a, 22% of control subjects; p &lt; 0.01).	Arginine	91-99	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	231-235
1459319-8	1992	Both diabetic groups also displayed a significant enrichment in DQA1 alleles positives for arginine at position 52 (65% of Type 1b; 76% of Type 1a; 50% of control subjects; p &lt; 0.01 and 0.001, respectively, vs controls), and in DQA1 Arg 52 positive homozygotes (48% of Type 1b, 58% of Type 1a, 22% of control subjects; p &lt; 0.01).	Arginine	236-239	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	64-68
1363553-6	1992	Depletion of L-arginine from endothelial monolayers increased 14C-sucrose permeability from 3.21 +/- 0.59 to 3.88 +/- 0.50 x 10(-5) cm.sec-1 (mean +/- SEM; n = 6; P &lt; 0.05).	Arginine	13-23	galactoside 2-alpha-L-fucosyltransferase SEC1	Bos taurus	135-140
1363553-7	1992	The acute administration of 5 x 10(-4) M L-arginine to monolayers depleted of this amino acid decreased 14C-sucrose permeability from 2.91 +/- 0.27 to 2.52 +/- 0.26 x 10(-5) cm.sec-1 (n = 11; P &lt; 0.05).	Arginine	41-51	galactoside 2-alpha-L-fucosyltransferase SEC1	Bos taurus	177-182
1569181-8	1992	The demonstration that this mutant Factor VIII has cofactor function when separated from vWf indicates that the dissociation of Factor VIII from vWf is an essential effect of Factor VIII light chain cleavage at arginine-1689.	Arginine	211-219	cytochrome c oxidase subunit 8A	Homo sapiens	42-46
1569181-8	1992	The demonstration that this mutant Factor VIII has cofactor function when separated from vWf indicates that the dissociation of Factor VIII from vWf is an essential effect of Factor VIII light chain cleavage at arginine-1689.	Arginine	211-219	cytochrome c oxidase subunit 8A	Homo sapiens	135-139
1569181-8	1992	The demonstration that this mutant Factor VIII has cofactor function when separated from vWf indicates that the dissociation of Factor VIII from vWf is an essential effect of Factor VIII light chain cleavage at arginine-1689.	Arginine	211-219	cytochrome c oxidase subunit 8A	Homo sapiens	135-139
1314172-5	1992	It differs from wild-type MxA by a Glu to Arg substitution near the carboxy terminus.	Arginine	42-45	MX dynamin like GTPase 1	Homo sapiens	26-29
1349567-4	1992	Five were detected as loss of a natural or introduced TaqI site at codons -5, 583, 1941, 2116, and 2209 and were confirmed as CGA (Arg) to TGA (Stop) nonsense mutations by DNA sequencing.	Arginine	131-134	T-box transcription factor 1	Homo sapiens	139-142
1532584-7	1992	We found that expression of cyclin B2 carrying a mutation at arginine 32 (to serine) caused HeLa cells to arrest in a pseudomitotic state.	Arginine	61-69	cyclin B2	Homo sapiens	28-37
1551498-1	1992	Insulin-dependent diabetes mellitus (IDDM) in whites is strongly associated with particular HLA-DQ alpha beta heterodimers composed of a DQ alpha chain with an arginine at residue 52 (Arg52+) combined to a DQ beta chain lacking an aspartic acid at residue 57 (Asp57-).	Arginine	160-168	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	92-95
1541289-14	1992	From the amino acid compositions, it appears that all six proteins are rich in arginine, cysteine and histidine and are closely related to pmP2 and mP2.	Arginine	79-87	peripheral myelin protein 2	Mus musculus	139-143
1737795-0	1992	Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis.	Arginine	30-33	ral guanine nucleotide dissociation stimulator	Homo sapiens	47-51
1732004-9	1992	These results illustrate the importance of Arg 53 of the mature vWF subunit for the binding of FVIII to vWF, and identify an amino acid residue within a disulfide loop not previously known to be involved in this interaction.	Arginine	43-46	coagulation factor VIII	Homo sapiens	95-100
1581002-3	1992	PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position.	Arginine	125-128	p21 (RAC1) activated kinase 2	Homo sapiens	0-5
1581002-3	1992	PAK-2 possesses the anionic center but has not a cationic binding center which might be provided by a guanidinium group from Arg-69 located adjacent to the Arg-71 position.	Arginine	156-159	p21 (RAC1) activated kinase 2	Homo sapiens	0-5
1309773-7	1992	Isopeptidase T acts on polyUb-protein conjugates, but not on conjugates in which the formation of polyUb chains was prevented by the use of reductively methylated Ub or on abnormal polyUb chains formed with a mutant Ub that contains a Lys----Arg substitution at residue 48.	Arginine	242-245	ubiquitin specific peptidase 5	Homo sapiens	0-14
1472636-1	1992	According to recent evidence, the presence of an Arg residue at position 52 in the HLA-DQ alpha chain may confer susceptibility to Type 1 diabetes and thus be possibly used to define quantitatively the genetic risk of this disease.	Arginine	49-52	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	83-86
1513806-0	1992	Responsiveness and memory of the pancreatic B-cells to the insulin secretagogues D-glucose and L-arginine in prediabetic and diabetic rabbits.	Arginine	95-105	insulin	Oryctolagus cuniculus	59-66
1513806-5	1992	In perfused control pancreas, the priming effect of D-glucose resulted in a time-dependent potentiation (TDP) of insulin release during subsequent L-arginine stimulus, whereas L-arginine induced a time-dependent inhibition (TDI) of insulin release during subsequent D-glucose stimulus.	Arginine	147-157	insulin	Oryctolagus cuniculus	113-120
6325477-3	1984	Since the Ca2+-activated proteinase is very likely to be a trypsin-like enzyme, with a preference for arginyl and lysyl peptide bonds, the results indicate that the arginine residues of the amino-terminal polypeptide of vimentin and desmin are highly essential for filament assembly but largely dispensable for the binding of both proteins to nucleic acids.	Arginine	165-173	desmin	Mus musculus	233-239
6582486-6	1984	Amino acid sequence analysis of the abnormal peptide indicated that the arginine-47 of normal antithrombin III had been replaced by cysteine in antithrombin III Toyama.	Arginine	72-80	serpin family C member 1	Homo sapiens	94-110
6582486-6	1984	Amino acid sequence analysis of the abnormal peptide indicated that the arginine-47 of normal antithrombin III had been replaced by cysteine in antithrombin III Toyama.	Arginine	72-80	serpin family C member 1	Homo sapiens	94-106
1387746-0	1992	[The effect of arginine on hydrolysis of fibrinogen by plasmin and mini-plasmin].	Arginine	15-23	plasminogen	Homo sapiens	55-62
1387746-1	1992	The rate of plasmin or Val442-plasmin catalyzed hydrolysis of fibrinogen decreases several times as affected by arginine in high concentrations.	Arginine	112-120	plasminogen	Homo sapiens	12-19
1387746-1	1992	The rate of plasmin or Val442-plasmin catalyzed hydrolysis of fibrinogen decreases several times as affected by arginine in high concentrations.	Arginine	112-120	plasminogen	Homo sapiens	30-37
6229250-1	1983	Purified m beta-acrosin catalysed amidolysis in vitro of several p-nitroanilides with C-terminal arginine residues.	Arginine	97-105	acrosin	Homo sapiens	16-23
1797690-2	1991	To enable a judgement to be made on the growth hormone stimulated through arginine, 23 amino acids were determined from the serum of non-hypophysectomized and hypophysectomized animals in each case.	Arginine	74-82	gonadotropin releasing hormone receptor	Rattus norvegicus	40-54
6371338-0	1983	[The variation of low molecular weight protein level after intravenous arginine administration--correlation between renal tubular function and the level of beta 2-microglobulin].	Arginine	71-79	beta-2-microglobulin	Homo sapiens	156-176
6313713-6	1983	This was supported by the observation that arginine inhibits the formation of intermediate filaments from intact vimentin.	Arginine	43-51	vimentin	Homo sapiens	113-121
6313713-9	1983	Beside vimentin, desmin, the 68 X 10(3) Mr neurofilament triplet protein, the glial fibrillary acidic protein and cytokeratins also bound to arginine methylester Sepharose 4B in a salt-stable manner and could be eluted with arginine.	Arginine	141-149	desmin	Homo sapiens	17-23
6313713-11	1983	Among the degradation products of vimentin produced by the specific, Ca2+-activated proteinase, only those with molecular weights higher than 40 X 10(3) bound to arginine methylester Sepharose 4B.	Arginine	162-170	vimentin	Homo sapiens	34-42
6830252-1	1983	The kinetic mechanism of bovine liver argininosuccinate lyase has been determined at pH 7.5, 25 degrees C. Fumarate and arginine are both noncompetitive inhibitors versus argininosuccinate.	Arginine	120-128	argininosuccinate lyase	Bos taurus	38-61
6338832-1	1983	The inhibition of thrombin by antithrombin-III involves formation of a 1:1 covalent complex between protease and inhibitor and concomitant cleavage of the antithrombin-III peptide chain after Arg-385.	Arginine	192-195	serpin family C member 1	Homo sapiens	30-46
6338832-1	1983	The inhibition of thrombin by antithrombin-III involves formation of a 1:1 covalent complex between protease and inhibitor and concomitant cleavage of the antithrombin-III peptide chain after Arg-385.	Arginine	192-195	serpin family C member 1	Homo sapiens	155-171
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	72-80	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	102-106
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	72-80	arginase	Saccharomyces cerevisiae S288C	111-115
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	148-156	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	102-106
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	148-156	arginase	Saccharomyces cerevisiae S288C	111-115
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	148-156	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	102-106
6343780-5	1983	Similarly we have measured the mRNA levels for two genes subject to the arginine specific regulation: ARG3 and CAR1, the former gene belongs to the arginine anabolic pathway and the latter to the arginine catabolic one.	Arginine	148-156	arginase	Saccharomyces cerevisiae S288C	111-115
6343780-7	1983	However, arginine does not reduce the level of the ARG3 mRNA enough to explain the reduction of ornithine carbamoyltransferase activity nor does it increase the level of the CAR1 mRNA enough to explain the extent of induction of arginase.	Arginine	9-17	arginase	Saccharomyces cerevisiae S288C	174-178
6185152-2	1982	Fibronectin was purified from rat plasma by affinity chromatography on gelatin-Sepharose and arginine-Sepharose columns.	Arginine	93-101	fibronectin 1	Rattus norvegicus	0-11
7158628-0	1982	Hemoglobin Queens: alpha 34 (B15) Leu-Arg structural and functional properties and its association with Hb E.	Arginine	38-41	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	29-32
7158628-1	1982	Hemoglobin Queens: alpha 34 (B15) Leu-Arg was found in association with Hb E in a Vietnamese boy.	Arginine	38-41	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	29-32
6191200-2	1982	Antigenic activity (in rabbits) was localized to several peptic fragments and the single arginine residue of bovine alpha-lactalbumin.	Arginine	89-97	lactalbumin alpha	Bos taurus	116-133
7167239-0	1982	[Behavior of serum gastrin after infusion of arginine in patients with gastric diseases.	Arginine	45-53	gastrin	Homo sapiens	19-26
6179939-14	1982	The sequence Arg-Lys precedes somatostatin-14.	Arginine	13-16	somatostatin-1	Ictalurus punctatus	30-45
6977539-9	1982	The fact that identical results were obtained for the reactions between antithrombin and three enzymes with different specificities strongly suggests that the observed Arg-Ser cleavage site is the active site of antithrombin.	Arginine	168-171	serpin family C member 1	Homo sapiens	72-84
6977539-9	1982	The fact that identical results were obtained for the reactions between antithrombin and three enzymes with different specificities strongly suggests that the observed Arg-Ser cleavage site is the active site of antithrombin.	Arginine	168-171	serpin family C member 1	Homo sapiens	212-224
6172444-3	1982	The synthetic 8-amino acid C-peptide segment of IGF-II (Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg) was covalently linked to thyroglobulin to render it more antigenic.	Arginine	60-63	insulin like growth factor 2	Homo sapiens	48-54
6172444-3	1982	The synthetic 8-amino acid C-peptide segment of IGF-II (Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg) was covalently linked to thyroglobulin to render it more antigenic.	Arginine	72-75	insulin like growth factor 2	Homo sapiens	48-54
6329685-1	1982	A peptide Tyr.Arg.Asp.Leu.Lys.Leu corresponding to the carboxy-terminal six amino acids of small-t antigen predicted from the DNA sequence of SV40 was synthesised, coupled to bovine serum albumin and to ovalbumin and used to raise antibody in rabbits.	Arginine	14-17	albumin	Oryctolagus cuniculus	182-195
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Arginine	265-268	gonadotropin releasing hormone 1	Rattus norvegicus	27-64
7019446-1	1981	Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10).	Arginine	265-268	gonadotropin releasing hormone 1	Rattus norvegicus	66-71
7450901-3	1981	Platelet-activating factor (PAF) is released in vitro during human and rabbit polymorphonuclear neutrophil (PMN) aggregation induced by C5a anaphylatoxin, neutrophil cationic proteins (CP) and their carboxypeptidase-B-derived fragments, C5a des Arg and CP des Arg, as well as phagocytosis of opsonized baker"s yeast particles and immune complexes (IC).	Arginine	245-248	PCNA clamp associated factor	Homo sapiens	0-26
7450901-3	1981	Platelet-activating factor (PAF) is released in vitro during human and rabbit polymorphonuclear neutrophil (PMN) aggregation induced by C5a anaphylatoxin, neutrophil cationic proteins (CP) and their carboxypeptidase-B-derived fragments, C5a des Arg and CP des Arg, as well as phagocytosis of opsonized baker"s yeast particles and immune complexes (IC).	Arginine	245-248	PCNA clamp associated factor	Homo sapiens	28-31
7450901-3	1981	Platelet-activating factor (PAF) is released in vitro during human and rabbit polymorphonuclear neutrophil (PMN) aggregation induced by C5a anaphylatoxin, neutrophil cationic proteins (CP) and their carboxypeptidase-B-derived fragments, C5a des Arg and CP des Arg, as well as phagocytosis of opsonized baker"s yeast particles and immune complexes (IC).	Arginine	260-263	PCNA clamp associated factor	Homo sapiens	0-26
7450901-3	1981	Platelet-activating factor (PAF) is released in vitro during human and rabbit polymorphonuclear neutrophil (PMN) aggregation induced by C5a anaphylatoxin, neutrophil cationic proteins (CP) and their carboxypeptidase-B-derived fragments, C5a des Arg and CP des Arg, as well as phagocytosis of opsonized baker"s yeast particles and immune complexes (IC).	Arginine	260-263	PCNA clamp associated factor	Homo sapiens	28-31
7450901-9	1981	We suggest that PAF is probably the final, common, effector substance of IC-, C5a-, C5a-des-Arg-, CP-, CP-des-Arg-mediated PMN aggregation.	Arginine	92-95	PCNA clamp associated factor	Homo sapiens	16-19
7450901-9	1981	We suggest that PAF is probably the final, common, effector substance of IC-, C5a-, C5a-des-Arg-, CP-, CP-des-Arg-mediated PMN aggregation.	Arginine	110-113	PCNA clamp associated factor	Homo sapiens	16-19
7024504-6	1981	To adsorb acrosin, it was found that the ligand should be longer than tripeptide with Arg in the carboxy-termini.	Arginine	86-89	acrosin	Homo sapiens	10-17
6966584-1	1980	The C-terminal amino acid sequences of human and of porcine antithrombin III have been determined as Gly-Arg-Val-Ala-Asn-Pro-Cys-Val-Lys and Gly-Arg-Val-Ala-Asn-Pro-Cys, respectively.	Arginine	105-108	serpin family C member 1	Homo sapiens	60-76
6104406-2	1980	After stimulation of insulin release with glucose and arginine, respectively, a prompt decrease in PP levels was found in pancreatic venous blood.	Arginine	54-62	pancreatic polypeptide	Sus scrofa	99-101
6104918-4	1980	The increase in plasma gastrin induced by arginine pulse was significantly suppressed by the infusion of beta-adrenergic blocking agent, propranolol, while the infusion of alpha-adrenergic blocking agent, phentolamine tended to enhance the arginine-induced gastrin secretion slightly but not significantly.	Arginine	240-248	gastrin	Homo sapiens	23-30
6104918-6	1980	These results suggest that alpha- and beta-adrenergic receptors play an important role in the regulation of arginine-induced gastrin secretion.	Arginine	108-116	gastrin	Homo sapiens	125-132
7014359-1	1980	The frequency of UV-induced arg+ and his+ reversions is found to be enhanced by the presence of colicinogenic plasmids Ib-P9 and Ia-CA53 and reduced by the presence of plasmid V-K30.	Arginine	28-31	cellular communication network factor 3	Homo sapiens	119-124
463493-0	1979	Serum gastrin in portal and peripheral veins after arginine in man.	Arginine	51-59	gastrin	Homo sapiens	6-13
309768-5	1978	In addition to the active form of rat anaphylatoxin, a serum carboxypeptidase B inactivated form of C3a (C3ades-Arg) was purified from rat serum and utilized in subsequent structural studies.	Arginine	112-115	carboxypeptidase B1	Rattus norvegicus	61-79
111689-0	1978	[Evidence of arginine residues in swine kidney diamine oxidase].	Arginine	13-21	amine oxidase copper containing 1	Sus scrofa	47-62
31359-9	1978	Unlike cathepsin B, the new cathepsin scarcely hydrolyzes N-substituted derivatives of arginine.	Arginine	87-95	cathepsin B	Rattus norvegicus	7-18
97200-5	1978	Time dependent inactivation of kallikrein by AT III, and AT III-heparin complex was shown by means of a synthetic kallikrein substrate: Bz-Pro-Phe-Arg-pNan.	Arginine	147-150	serpin family C member 1	Homo sapiens	45-51
97200-5	1978	Time dependent inactivation of kallikrein by AT III, and AT III-heparin complex was shown by means of a synthetic kallikrein substrate: Bz-Pro-Phe-Arg-pNan.	Arginine	147-150	serpin family C member 1	Homo sapiens	57-63
656053-2	1978	We have previously shown that an antigenic site (site 1) in native lysozyme resides around the disulphide bond 6-127 and, by classical synthesis of nine disulphide peptides, the antigenic site was accurately narrowed down to the structure Cys((6))-Arg((14))-[Cys((6))-Cys((127))] -Gly((126))-Arg((128)).	Arginine	248-251	lysozyme C-like	Oryctolagus cuniculus	67-75
656053-2	1978	We have previously shown that an antigenic site (site 1) in native lysozyme resides around the disulphide bond 6-127 and, by classical synthesis of nine disulphide peptides, the antigenic site was accurately narrowed down to the structure Cys((6))-Arg((14))-[Cys((6))-Cys((127))] -Gly((126))-Arg((128)).	Arginine	292-295	lysozyme C-like	Oryctolagus cuniculus	67-75
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Arginine	41-44	lysozyme C-like	Oryctolagus cuniculus	113-121
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Arginine	41-44	lysozyme C-like	Oryctolagus cuniculus	284-292
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Arginine	53-56	lysozyme C-like	Oryctolagus cuniculus	113-121
656053-10	1978	The surface-simulation synthetic peptide Arg-Gly-Gly-Arg-Gly-Glu-Gly-Gly-Arg-Lys (which does not exist in native lysozyme, but copies a surface region of it) accounted entirely for the maximum expected reactivity of the site (i.e. about one-third of the total antigenic reactivity of lysozyme).	Arginine	53-56	lysozyme C-like	Oryctolagus cuniculus	284-292
590939-0	1977	[Modification of arginine residues in pyruvate kinase (author"s transl)].	Arginine	17-25	pyruvate kinase PKLR	Oryctolagus cuniculus	38-53
323257-9	1977	The decrease in the ability of CTP to inhibit the enzyme correlates with the loss of 2 arginine residues/regulatory chain (Mr = 17,000).	Arginine	87-95	solute carrier family 25 member 1	Homo sapiens	31-34
615733-0	1977	Gastrin release in response to arginine infusion.	Arginine	31-39	gastrin	Homo sapiens	0-7
615733-1	1977	Intravenous infusion of arginine has been reported to be a powerful stimulus of endogenous gastrin release.	Arginine	24-32	gastrin	Homo sapiens	91-98
615733-4	1977	Changes in overall mean serum gastrin were small and showed a significant (p less than 0.05) rise over mean basal levels at only one point in time which was during arginine infusion.	Arginine	164-172	gastrin	Homo sapiens	30-37
615733-5	1977	In this study arginine infusion resulted in a much smaller and less consistent serum gastrin response than previous reports.	Arginine	14-22	gastrin	Homo sapiens	85-92
197036-3	1977	A solution synthesis is described of the partially protected N alpha-benzyloxycarbonylheptadecapeptide Z-Lys (Tfa)-Thr-Glu-Arg-Glu-Asp-Leu-Ile-Ala-Tyr-Leu-Lys (Tfa)-Lys (Tfa)-Ala-Thr-Asn-Glu (OBu t)-OBu t corresponding to sequence 88-104 of horse heart cytochrome c.	Arginine	123-126	cytochrome c, somatic	Equus caballus	253-265
789352-0	1976	Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis.	Arginine	14-22	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	118-148
789352-2	1976	The level of ornithine carbamoyltransferase in this mutation is depressed and less repressible by addition of L-arginine than it is in the wild-type strain.	Arginine	110-120	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	13-43
988018-5	1976	D-II was quite unique because its both reactive sites are arginine residues and it only inhibits trypsin.	Arginine	58-66	Bowman-Birk type proteinase inhibitor D-II	Glycine max	0-4
988018-6	1976	It is suggested that D-II might be a primitive form of double-headed inhibitor and that the prototype single-headed inhibitor was a trypsin inhibitor with an arginine residue as the reactive site.	Arginine	158-166	Bowman-Birk type proteinase inhibitor D-II	Glycine max	21-25
1249071-8	1976	The COOH-terminal arginine residue of EGF was quantitatively removed by digestion with carboxypeptidase B...	Arginine	18-26	epidermal growth factor	Mus musculus	38-41
51408-0	1975	Increased urinary excretion of albumin, light chains, and beta2-microglobulin after intravenous arginine administration in normal man.	Arginine	96-104	beta-2-microglobulin	Homo sapiens	58-77
5774112-0	1969	Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man.	Arginine	120-128	gastrin	Homo sapiens	38-45
5735916-0	1968	[Competing interactions of lysine (f-1) and arginine (f-3) rich histone fractions during nucleohistone formation].	Arginine	44-52	coagulation factor III, tissue factor	Homo sapiens	54-57
13720237-2	1961	The effect of a suppressor mutation which renders pyr 3a pyrimidine-independent is to reduce arginine levels in the mycelium by its effect on ornithine transcarbamylase.	Arginine	93-101	ornithine transcarbamylase	Homo sapiens	142-168
33872670-0	2021	Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteinsduring mitophagy.	Arginine	46-54	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	8-13
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	21-29	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	233-238
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Arginine	130-133	ral guanine nucleotide dissociation stimulator	Homo sapiens	147-151
1719976-6	1991	L-arginine-derived nitric oxide may be a source of activation of guanylate cyclase in the retina.	Arginine	0-10	guanylate cyclase	Bos taurus	65-82
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	142-150	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	233-238
1931947-4	1991	Arg-43 is invariant in all known mammalian CG/lutropin beta amino acid sequences, and Arg-94 is conserved in 10 of the 12 sequences.	Arginine	0-3	chorionic gonadotropin subunit beta 5	Homo sapiens	43-45
1924357-6	1991	Conversely, dipeptides His-Ala, Arg-Ala, and Lys-Ala inhibit the degradation of Arg-nsP4 but not of Tyr-nsP4 or Phe-nsP4.	Arginine	32-35	serine protease 57	Homo sapiens	84-88
33611046-6	2021	Moreover, the Ru9.8/r-CoP catalyst also shows good reusability.	Arginine	2-3	caspase recruitment domain family member 16	Homo sapiens	22-25
1924357-6	1991	Conversely, dipeptides His-Ala, Arg-Ala, and Lys-Ala inhibit the degradation of Arg-nsP4 but not of Tyr-nsP4 or Phe-nsP4.	Arginine	80-83	serine protease 57	Homo sapiens	84-88
1924310-9	1991	This region of Tat exhibits substantially more activity than the N-terminal 58 amino acids of Tat, which includes the arginine-rich basic region.	Arginine	118-126	tyrosine aminotransferase	Homo sapiens	15-18
34018522-4	2021	The results showed that EGCG significantly attenuated l-arginine-induced AP and the consequent pulmonary damage in mice.	Arginine	54-64	LIM homeobox protein 2	Mus musculus	73-75
1924310-9	1991	This region of Tat exhibits substantially more activity than the N-terminal 58 amino acids of Tat, which includes the arginine-rich basic region.	Arginine	118-126	tyrosine aminotransferase	Homo sapiens	94-97
1930163-4	1991	However, proreninR-4 was detectably cleaved to yield the active renin upon co-transfection with furin DNA, indicating that Arg at position -4 is important for recognition and processing by furin in addition to the absolute requirement for paired basic amino acids.	Arginine	123-126	furin, paired basic amino acid cleaving enzyme	Homo sapiens	189-194
33929180-1	2021	Editing of the pre-mRNA of the DNA repair glycosylase NEIL1 results in substitution of a Lys with Arg in the lesion recognition loop of the enzyme.	Arginine	98-101	nei like DNA glycosylase 1	Homo sapiens	54-59
1770316-13	1991	The first base of the Arg codon (CGA) at residue 412 in exon 10 was replaced by a T, resulting in a termination codon (TGA).	Arginine	22-25	T-box transcription factor 1	Homo sapiens	119-122
33979616-3	2021	In this study, we show that tumor cells synthesize arginine from citrulline by upregulating argininosuccinate synthetase 1 (ASS1).	Arginine	51-59	argininosuccinate synthase 1	Homo sapiens	92-122
33979616-3	2021	In this study, we show that tumor cells synthesize arginine from citrulline by upregulating argininosuccinate synthetase 1 (ASS1).	Arginine	51-59	argininosuccinate synthase 1	Homo sapiens	124-128
33979616-4	2021	Under arginine starvation, ASS1 transcription is induced by ATF4 and CEBPbeta binding to an enhancer within ASS1.	Arginine	6-14	argininosuccinate synthase 1	Homo sapiens	27-31
33979616-4	2021	Under arginine starvation, ASS1 transcription is induced by ATF4 and CEBPbeta binding to an enhancer within ASS1.	Arginine	6-14	argininosuccinate synthase 1	Homo sapiens	108-112
1859379-6	1991	The inhibitory potency of ursolic acid is also reduced by addition of 1 M-NaCl, further supporting a postulated electrostatic interaction between the negative charge on the triterpene and a positively charged residue on the enzyme, which we assign to the side chain of Arg-217, located in the vicinity of subsites S4 and S5 in HLE.	Arginine	269-272	elastase, neutrophil expressed	Homo sapiens	327-330
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	383-393	interleukin 23 subunit alpha	Homo sapiens	18-23
33956666-2	2021	Here we show that IL-23 receptor (IL-23R) expressing murine and human renal tubular epithelial cells (TEC) respond to IL-23 by inducing intracellular calcium flux, enhanced glycolysis, and the upregulation of calcium/calmodulin kinase IV (CaMK4) which results in suppression of the expression of the arginine degrading enzyme arginase 1 (ARG1) thus increasing in situ levels of free L-Arginine (Arg).	Arginine	385-388	interleukin 23 subunit alpha	Homo sapiens	18-23
1751226-4	1991	Furthermore, incorporation of the well known cell adhesive ligand Arg-Gly-Asp-Ser (RGDS) peptidyl moiety into the above co-polymer resulted, on UV light irradiation, in a three-dimensional hydrophilic gel matrix containing cell adhesive ligands.	Arginine	66-69	ral guanine nucleotide dissociation stimulator	Homo sapiens	83-87
33896016-7	2021	Mechanistically, Prmt5, encoding protein arginine methyltransferase 5, which catalyzes SDMA formation from arginine, was highly induced in HCC and identified as a direct MYC target gene.	Arginine	41-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	170-173
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Arginine	73-76	SAFB like transcription modulator	Homo sapiens	138-141
33881737-4	2021	RESULTS: The sugars mannitol, sucrose and trehalose, and the amino acids Arg, Lys, and His significantly promote the oxidation of peptide Met to peptide Met sulfoxide.	Arginine	73-76	SAFB like transcription modulator	Homo sapiens	153-156
33872411-4	2021	Protein arginine methyltransferase 5 (PRMT5) functions in concert with the methylosome protein 50 (MEP50) cofactor to catalyze symmetric dimethylation of key arginine resides in histones 3 and 4 which modifies the chromatin environment to alter tumor suppressor and oncogene expression and enhance cancer cell survival.	Arginine	8-16	WD repeat domain 77	Homo sapiens	75-97
33872411-4	2021	Protein arginine methyltransferase 5 (PRMT5) functions in concert with the methylosome protein 50 (MEP50) cofactor to catalyze symmetric dimethylation of key arginine resides in histones 3 and 4 which modifies the chromatin environment to alter tumor suppressor and oncogene expression and enhance cancer cell survival.	Arginine	8-16	WD repeat domain 77	Homo sapiens	99-104
33660773-6	2021	During induced erythroid maturation of K562 cells, decreasing arginine dimethylation of HNRNPK is linked to a reduced interaction with RPS19 in vitro and in vivo.	Arginine	62-70	ribosomal protein S19	Homo sapiens	135-140
33716169-6	2021	OGT and its interaction partners were immunoprecipitated from OGT wild-type, null and hydrogen peroxide treated cell lysates that had been isotopically labeled with light, medium and heavy lysine and arginine (stable isotopic labeling of amino acids in cell culture [SILAC]).	Arginine	200-208	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
33533925-0	2021	A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol.	Arginine	9-17	DNA polymerase delta interacting protein 2	Homo sapiens	29-36
33533925-7	2021	This stimulation is dependent on a unique arginine cluster in PolDIP2.	Arginine	42-50	DNA polymerase delta interacting protein 2	Homo sapiens	62-69
33418111-0	2021	Asymmetrical Arginine Dimethylation of Histone H4 by 8-oxoG/OGG1/PRMT1 is Essential for Oxidative Stress-induced Transcription Activation.	Arginine	13-21	8-oxoguanine DNA glycosylase	Homo sapiens	60-64
33183638-4	2021	In this study, a novel N-acetyl-L-cysteine and arginine modified hydroxypropyl-beta-cyclodextrin (NAC-HP-beta-CD-Arg) was successfully synthesized and characterized.	Arginine	47-55	synuclein alpha	Homo sapiens	98-101
33449925-7	2021	The same area of common ROH was also present in DIT, while a broader region (~49.25-51.94Mbp) was shared among the ARG, CCG, and GGT.	Arginine	115-118	myelin basic protein	Capra hircus	89-92
33177195-7	2021	Examination of a comprehensive set of substitution or deletion mutants of BToN fused with EGFP revealed that clusters of arginine (R) residues comprise nuclear/nucleolar localization signals (NLS/NoLS), and the C-terminal region served as a chromosomal maintenance 1 (CRM1)-independent nuclear export signal (NES).	Arginine	131-132	exportin 1	Homo sapiens	268-272
33440850-5	2021	Cp deamidation occurs at two Asparagine-Glycine-Arginine (NGR)-motifs which, once deamidated to isoAspartate-Glycine-Arginine (isoDGR), bind integrins, a family of receptors mediating cell adhesion.	Arginine	48-56	ceruloplasmin	Homo sapiens	0-2
33232925-10	2021	CONCLUSION: UA aggravates MI/R-induced activation of the NLRP3 inflammatory cascade and pyroptosis by promoting ROS generation, while inflammasome inhibitors and ROS scavengers partly reverse the injury.	Arginine	29-30	NLR family, pyrin domain containing 3	Mus musculus	57-62
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	kelch like ECH associated protein 1	Bos taurus	204-209
33311482-2	2020	Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, in the pancreas of mice with cerulean- or L-arginine-induced pancreatitis, and in an oncogenic Kras murine model of spontaneous pancreatic ductal adenocarcinoma (PDAC).	Arginine	183-193	glutathione peroxidase 4	Mus musculus	64-68
33311482-2	2020	Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, in the pancreas of mice with cerulean- or L-arginine-induced pancreatitis, and in an oncogenic Kras murine model of spontaneous pancreatic ductal adenocarcinoma (PDAC).	Arginine	183-193	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	236-240
32216002-2	2020	Recently, a de novo arginine to cysteine (R311C) mutation in CaMKK2 was identified from a whole exome sequencing study of bipolar patients and their unaffected parents.	Arginine	20-28	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	61-67
32956996-0	2020	Silencing of survivin and cyclin B1 through siRNA-loaded arginine modified calcium phosphate nanoparticles for non-small-cell lung cancer therapy.	Arginine	57-65	cyclin B1	Homo sapiens	26-35
32725514-0	2020	IFN-gamma Activates the TLR4-CCL5 Signaling Through Reducing Arginine Level, Leading to Enhanced Susceptibility of Bovine Mammary Epithelial Cells to Staphylococcus aureus.	Arginine	61-69	toll like receptor 4	Bos taurus	24-28
32725514-5	2020	IFN-gamma increased the activity of arginase II and reduced the level of arginine in cells, while the addition of arginine inhibited the expression of TLR4 and CCL5.	Arginine	114-122	toll like receptor 4	Bos taurus	151-155
33222863-12	2020	The individual AA Leu, Met, Ile, and Arg increased S6K1 phosphorylation in an insulin-dependent manner.	Arginine	37-40	insulin	Bos taurus	78-85
33222863-13	2020	Similarly, Met and Arg increased 4E-BP1 phosphorylation in an insulin-dependent manner.	Arginine	19-22	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	33-39
33222863-13	2020	Similarly, Met and Arg increased 4E-BP1 phosphorylation in an insulin-dependent manner.	Arginine	19-22	insulin	Bos taurus	62-69
32932187-9	2020	Interestingly, as a precursor of nitric oxide, Arg supplementation can rescue the effects of feed restriction on follicular development by enhancing glucose metabolism and cell proliferation of GCs, and alleviating the abnormal E2 secretion in the >=2.5 mm follicles, accompanied with recovering the expressions of NPVF and GNRH in the hypothalamus.	Arginine	47-50	Progonadoliberin-1	Ovis aries	324-328
33457310-4	2020	The novel missense mutation caused the substitution of codon 94 for leucine in the HMG box of the SRY protein with an arginine codon.	Arginine	118-126	sex determining region Y	Homo sapiens	98-101
33266231-2	2020	However, at an inflammatory focus, arginine residues in LL-37 can be converted to citrulline via a reaction catalyzed by peptidyl-arginine deiminases (PAD2 and PAD4), which are expressed in neutrophils and are highly active during the formation of neutrophil extracellular traps (NETs).	Arginine	35-43	peptidyl arginine deiminase 4	Homo sapiens	160-164
33255369-1	2020	Alterations in the L-arginine (Arg)/nitric oxide (NO) pathway have been reported in cystic fibrosis (CF; OMIM 219700) as the result of various factors including systemic and local inflammatory activity in the airways.	Arginine	19-29	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	31-34
2024489-3	1991	The 6 amino acid portion of the basic region containing five arginines is sufficient to confer Tar binding to overlapping Tat protein fragments; Tat fragments that lack the basic region do not bind Tar.	Arginine	61-70	tyrosine aminotransferase	Homo sapiens	122-125
33207191-8	2020	However, the introduction of two arginine residues to the chicken HJURP alphaA-helix suppresses CENP-A mis-incorporation in chicken cells expressing CENP-AA59Q.	Arginine	33-41	centromere protein A	Gallus gallus	96-102
1902836-6	1991	The prolonged expression of hsp70 RNA during recovery from heat shock was also observed in young flies fed canavanine, an arginine analogue.	Arginine	122-130	Heat-shock-protein-70Ab	Drosophila melanogaster	28-33
32945578-3	2020	Target site DNA base unstacking, flipping, and melting by RAG1 methionine 848 explain how this residue activates transposition, how RAG can stabilize sharp bends in target DNA, and why replacement of residue 848 by arginine during RAG domestication led to suppression of transposition activity.	Arginine	215-223	recombination activating 1	Homo sapiens	58-62
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	27-30	plasminogen	Homo sapiens	0-7
32859536-1	2020	BACKGROUND: Pre-clinical studies indicated that arginine-deprivation therapy using pegylated arginine deiminase (pegargiminase, ADI-PEG 20) may be effective in patients with argininosuccinate synthetase 1 (ASS1)-deficient small-cell lung cancer (SCLC).	Arginine	48-56	argininosuccinate synthase 1	Homo sapiens	174-204
32859536-1	2020	BACKGROUND: Pre-clinical studies indicated that arginine-deprivation therapy using pegylated arginine deiminase (pegargiminase, ADI-PEG 20) may be effective in patients with argininosuccinate synthetase 1 (ASS1)-deficient small-cell lung cancer (SCLC).	Arginine	48-56	argininosuccinate synthase 1	Homo sapiens	206-210
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	plasminogen	Homo sapiens	0-7
1828038-1	1991	Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.	Arginine	45-48	plasminogen	Homo sapiens	257-264
2017180-3	1991	A study of deletions and point mutations created in the 5" noncoding region of ARG3, ARG5,6, CAR1, and CAR2 genes shows that at least two regions, called BoxA and BoxB, are required for proper regulation of these genes by arginine and ARGR proteins.	Arginine	222-230	nuclear receptor subfamily 1 group I member 4	Homo sapiens	103-107
2015625-2	1991	Here, we demonstrate that this specific RNA-binding event is, as expected, mediated by the conserved arginine-rich motif of Rev.	Arginine	101-109	Rev	Human immunodeficiency virus 1	124-127
32911066-2	2020	Novel arginine-terminated PDs (+/-lipidation) were prepared by solid phase peptide synthesis, followed by conjugation onto ASP nanoliposomes.	Arginine	6-14	assembly factor for spindle microtubules	Homo sapiens	123-126
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	224-249
33092030-4	2020	L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation.	Arginine	0-10	catenin beta 1	Homo sapiens	318-330
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	57-60	ral guanine nucleotide dissociation stimulator	Homo sapiens	125-129
1750929-10	1991	The minimal active sequence within CS5, the tetrapeptide Arg-Glu-Asp-Val (REDV), is somewhat related to the Arg-Gly-Asp-Ser (RGDS) sequence that represents a major active site in the central cell-binding domain (CCBD) of fibronectin.	Arginine	108-111	ral guanine nucleotide dissociation stimulator	Homo sapiens	125-129
1671745-8	1991	On the other hand, catalase and/or H2O2 lead to a decrease in L-arginine-induced cyclic GMP formation.	Arginine	62-72	5'-nucleotidase, cytosolic II	Mus musculus	88-91
1671745-9	1991	Furthermore, NH2OH inhibited L-arginine- and sodium nitroprusside-induced cyclic GMP formation in the cytosol.	Arginine	29-39	5'-nucleotidase, cytosolic II	Mus musculus	81-84
1671745-10	1991	The inhibition of L-arginine-induced cyclic GMP formation in the cytosol by NH2OH was not reversed by the addition of superoxide dismutase.	Arginine	18-28	5'-nucleotidase, cytosolic II	Mus musculus	44-47
1899841-10	1991	Circular dichroism spectra suggest that the arginine-rich region of Tat is unstructured in the absence of RNA, becomes partially or fully structured upon binding, and induces a conformational change in the RNA.	Arginine	44-52	tyrosine aminotransferase	Homo sapiens	68-71
1850389-2	1991	In the presence of 10 mM D-glucose the C-terminal nonapeptide Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2 (S19-27) showed a 2-fold higher activity than that earlier shown for S22-27 and had the same effect on the dynamic pattern of insulin release as secretin, while the elongating sequence Leu-Gln-Arg (S19-21) had no effect on the insulin release.	Arginine	70-73	secretin	Mus musculus	247-255
2246265-8	1990	MAP also cleaved methionine from other tripeptides whose penultimate amino acid residue is relatively small and/or uncharged (e.g. Pro, Gly, Val, Thr, or Ser) but not when bulky and/or charged (Arg.	Arginine	194-197	methionine aminopeptidase	Saccharomyces cerevisiae S288C	0-3
2170021-2	1990	We describe here a gag mutant of Mason-Pfizer monkey virus, a type D retrovirus, in which a tryptophan substituted for an arginine in the matrix protein results in efficient assembly of capsids at the plasma membrane through a morphogenic process similar to that of type C retroviruses.	Arginine	122-130	Pr78	Mason-Pfizer monkey virus	19-22
1706487-3	1990	When the methylation of an arginine residue of MBP was examined in slices of the brainstem and spinal cord, using [3H]methionine as a donor of the methyl groups, no difference was found between Twi and the controls.	Arginine	27-35	myelin basic protein	Homo sapiens	47-50
2168881-2	1990	We now report that the synthetic peptide Gly-Arg-Gly-Arg-Ser-Ser-Val-Tyr-Ser, which corresponds to the phosphorylated region of Acanthamoeba myosin IC, is a good substrate for myosin I heavy chain kinase: Km = 54 microM, and Vmax = 15 mumols/min.mg.	Arginine	45-48	myosin IA	Homo sapiens	176-196
2168881-2	1990	We now report that the synthetic peptide Gly-Arg-Gly-Arg-Ser-Ser-Val-Tyr-Ser, which corresponds to the phosphorylated region of Acanthamoeba myosin IC, is a good substrate for myosin I heavy chain kinase: Km = 54 microM, and Vmax = 15 mumols/min.mg.	Arginine	53-56	myosin IA	Homo sapiens	176-196
2232482-6	1990	The pH optimum for cathepsin B (substrate: Z-Arg-Arg-HNMec) and L (substrate: Z-Phe-Arg-HNMec in the presence of Z-Phe-Phe-CHN2) was approximately pH 6.0 for both glomeruli and renal cortex; while that for cathepsin H (substrate: Arg-HNMec) was approximately 6.5.	Arginine	49-52	chimerin 2	Rattus norvegicus	123-127
2142154-7	1990	Activation of the rate of phosphorylation of a synthetic peptide, Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala, was observed on preincubation of the breakthrough fraction from unstimulated cell extracts with either of two distinct EGF-stimulated kinase activities, each of which phosphorylated myelin basic protein.	Arginine	66-69	myelin basic protein	Mus musculus	281-301
2142154-7	1990	Activation of the rate of phosphorylation of a synthetic peptide, Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala, was observed on preincubation of the breakthrough fraction from unstimulated cell extracts with either of two distinct EGF-stimulated kinase activities, each of which phosphorylated myelin basic protein.	Arginine	70-73	myelin basic protein	Mus musculus	281-301
2364072-0	1990	Arginine residues are involved in the transport function of bilitranslocase.	Arginine	0-8	ceruloplasmin	Rattus norvegicus	60-75
2198936-0	1990	Site-directed mutagenesis of recombinant rat DNA polymerase beta: involvement of arginine-183 in primer recognition.	Arginine	81-89	DNA polymerase beta	Rattus norvegicus	45-64
2198936-1	1990	By site-directed mutagenesis using synthetic oligonucleotides, amino acid residues 181Phe-Arg-Arg183 of recombinant rat DNA polymerase beta were replaced by other amino acids to clarify the roles of these residues in the DNA synthesizing reaction.	Arginine	90-93	DNA polymerase beta	Rattus norvegicus	120-139
2198936-8	1990	Therefore, it is concluded that Arg-183 occupies an important part of the primer recognition site of DNA polymerase beta.	Arginine	32-35	DNA polymerase beta	Rattus norvegicus	101-120
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
2182911-1	1990	The structural requirements for proteolytic cleavage of the human immunodeficiency virus type 1 env gene product, gp160, to gp120 and gp41 have been assessed by specific mutagenesis of the sequence Lys Ala Lys Arg Arg Val Val Glu Arg Glu Lys Arg located between amino acids 500 and 511, i.e., at the putative C terminus of gp120.	Arginine	214-217	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	114-119
2184574-8	1990	These results indicate that the arginine-rich basic domain of the trans-activator, Tat, and post-transcriptional trans-regulator, Rev, are functionally similar with regard to trans-activation of HIV-1 LTR.	Arginine	32-40	tyrosine aminotransferase	Homo sapiens	83-86
2184574-8	1990	These results indicate that the arginine-rich basic domain of the trans-activator, Tat, and post-transcriptional trans-regulator, Rev, are functionally similar with regard to trans-activation of HIV-1 LTR.	Arginine	32-40	Rev	Human immunodeficiency virus 1	130-133
2323577-1	1990	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells, is a single polypeptide rich in arginine.	Arginine	128-136	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	0-38
2323577-1	1990	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells, is a single polypeptide rich in arginine.	Arginine	128-136	myelin basic protein	Homo sapiens	40-43
2105216-5	1990	Comparison of the amino acid composition of beta-galactosidase from S. solfataricus with that from Escherichia coli revealed a lower cysteine content and a lower Arg/Lys ratio in the thermophilic enzyme.	Arginine	162-165	MFS transporter	Saccharolobus solfataricus	44-62
33232463-6	2021	We found a significantly higher prevalence of the minor allele of ARG1 rs2246012 in supplement users with higher blood l-arginine concentrations (P = 0.03).	Arginine	119-129	arginase 1	Homo sapiens	66-70
33232463-7	2021	Mean +- SEM l-arginine concentration was 263 +- 9.76 mumol/L in supplement users homozygous for the minor allele of ARG1 rs2246012 (P = 0.004); it was 70.4 +- 25.6 mumol/L in unsupplemented participants homozygous for the minor allele of ARG2 rs3759757 (P = 0.03).	Arginine	12-22	arginase 1	Homo sapiens	116-120
33232463-8	2021	The ARG1 haplotype was significantly associated with blood l-arginine concentrations in supplement users (P = 0.046), whereas the combined ARG1/ARG2 haplotype was significantly associated with blood l-arginine concentrations in the cohort as a whole (P = 0.012).	Arginine	59-69	arginase 1	Homo sapiens	4-8
33232463-8	2021	The ARG1 haplotype was significantly associated with blood l-arginine concentrations in supplement users (P = 0.046), whereas the combined ARG1/ARG2 haplotype was significantly associated with blood l-arginine concentrations in the cohort as a whole (P = 0.012).	Arginine	199-209	arginase 1	Homo sapiens	139-143
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	85-95	arginase 1	Homo sapiens	40-44
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	85-95	arginase 1	Homo sapiens	122-126
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	40-44
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	122-126
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	40-44
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	122-126
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	40-44
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 1	Homo sapiens	122-126
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	103-113	arginase 1	Homo sapiens	74-78
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	103-113	arginase 1	Homo sapiens	153-157
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	189-199	arginase 1	Homo sapiens	74-78
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	189-199	arginase 1	Homo sapiens	153-157
33782401-0	2021	Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.	Arginine	50-58	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	42-49
33782401-5	2021	We show that PRMT4/5/7-mediated arginine methylation regulates hnRNPA1 binding to RNA and several alternative splicing events.	Arginine	32-40	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	63-70
33782401-6	2021	In breast, colorectal and prostate cancer cells, PRMT4/5/7 are upregulated and associated with high levels of hnRNPA1 arginine methylation and aberrant alternative splicing.	Arginine	118-126	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	110-117
33762328-3	2021	Here, we identified protein arginine methyltransferase 5 (PRMT5) as a direct binding partner of cGAS, and it catalyzed the arginine symmetrical dimethylation of cGAS at the Arg124 residue.	Arginine	28-36	protein arginine N-methyltransferase 5	Mus musculus	58-63
33810051-7	2021	Whole exome sequencing revealed a novel potentially pathogenic arginine to cysteine substitution (p.Arg1265Cys) in the BCORL1 protein.	Arginine	63-71	BCL6 corepressor like 1	Homo sapiens	119-125
33162974-8	2020	Interestingly, arginine 190 is located in a structurally conserved region of STXBP2 where other f-HLH-5 mutations have been identified.	Arginine	15-23	syntaxin binding protein 2	Homo sapiens	77-83
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	interleukin 1 receptor associated kinase 1	Homo sapiens	32-37
32632916-7	2020	RESULTS: Mixed diet supplementation with L-ARG + ND prevented highly significant right ventricle enlargement induced by PAH in both, male and female rats.	Arginine	41-46	phenylalanine hydroxylase	Rattus norvegicus	120-123
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	hematopoietic SH2 domain containing	Homo sapiens	104-107
32739156-6	2020	Arginine-methylated H4R3 could associate with flap endonuclease 1 (FEN1) and enhance its nuclease activity and BER efficiency.	Arginine	0-8	flap structure-specific endonuclease 1	Homo sapiens	46-65
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	hematopoietic SH2 domain containing	Homo sapiens	185-188
32739156-6	2020	Arginine-methylated H4R3 could associate with flap endonuclease 1 (FEN1) and enhance its nuclease activity and BER efficiency.	Arginine	0-8	flap structure-specific endonuclease 1	Homo sapiens	67-71
25963836-15	2015	Present MD simulations highlight the role of the arginine residue of MUC1-G peptide in initiating the binding.	Arginine	49-57	mucin 1, cell surface associated	Homo sapiens	69-73
32787104-3	2020	Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross link them to adjacent cysteine residues.	Arginine	129-137	glutathione S-transferase pi 1	Homo sapiens	161-165
34911774-1	2022	Protein arginine methyltransferase 5 (PRMT5) participates in the symmetric dimethylation of arginine residues of proteins and contributes to a wide range of biological processes.	Arginine	92-100	protein arginine N-methyltransferase 5	Mus musculus	0-36
32640903-0	2020	Mutation of Arginine 264 on ERalpha (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility.	Arginine	12-20	estrogen receptor 1 (alpha)	Mus musculus	28-35
32640903-0	2020	Mutation of Arginine 264 on ERalpha (Estrogen Receptor Alpha) Selectively Abrogates the Rapid Signaling of Estradiol in the Endothelium Without Altering Fertility.	Arginine	12-20	estrogen receptor 1 (alpha)	Mus musculus	37-60
32640903-3	2020	Here, we studied the in vivo role of the arginine 260 of ERalpha which has also been described to be involved in its E2-induced rapid signaling with PI-3K (phosphoinositide 3-kinase) as well as G protein in cultured cell lines.	Arginine	41-49	estrogen receptor 1 (alpha)	Mus musculus	57-64
32640903-3	2020	Here, we studied the in vivo role of the arginine 260 of ERalpha which has also been described to be involved in its E2-induced rapid signaling with PI-3K (phosphoinositide 3-kinase) as well as G protein in cultured cell lines.	Arginine	41-49	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	156-181
34911774-1	2022	Protein arginine methyltransferase 5 (PRMT5) participates in the symmetric dimethylation of arginine residues of proteins and contributes to a wide range of biological processes.	Arginine	92-100	protein arginine N-methyltransferase 5	Mus musculus	38-43
32640903-4	2020	Approach and Results: We generated a mouse model harboring a point mutation of the murine counterpart of this arginine into alanine (R264A-ERalpha).	Arginine	110-118	estrogen receptor 1 (alpha)	Mus musculus	139-146
32640903-9	2020	CONCLUSIONS: These data underline the exquisite role of arginine 264 of ERalpha for endothelial membrane-initiated steroid signaling effects of E2 but not for nuclear/genomic actions.	Arginine	56-64	estrogen receptor 1 (alpha)	Mus musculus	72-79
34643933-0	2022	The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2.	Arginine	36-39	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	118-123
32652263-5	2020	Compared with the Lys-rich metallopeptide (Ru1), however, the third-strand stabilizating effect of the Arg-rich one (Ru2) is slightly more marked, which may be due to differences in the interactions of arginine and lysine residues with the third strand of the triplex.	Arginine	103-106	Scm like with four mbt domains 1	Homo sapiens	43-46
32652263-5	2020	Compared with the Lys-rich metallopeptide (Ru1), however, the third-strand stabilizating effect of the Arg-rich one (Ru2) is slightly more marked, which may be due to differences in the interactions of arginine and lysine residues with the third strand of the triplex.	Arginine	103-106	doublecortin domain containing 2	Homo sapiens	117-120
32652263-5	2020	Compared with the Lys-rich metallopeptide (Ru1), however, the third-strand stabilizating effect of the Arg-rich one (Ru2) is slightly more marked, which may be due to differences in the interactions of arginine and lysine residues with the third strand of the triplex.	Arginine	202-210	doublecortin domain containing 2	Homo sapiens	117-120
34918843-3	2022	Two contrasting metabolic enzymes that use arginine as a substrate, inducible nitric oxide synthase (iNOS), and arginase-1 (Arg-1), have been identified as M1-MPhi and M2-MPhi markers, respectively.	Arginine	43-51	arginase, liver	Mus musculus	112-122
34918843-3	2022	Two contrasting metabolic enzymes that use arginine as a substrate, inducible nitric oxide synthase (iNOS), and arginase-1 (Arg-1), have been identified as M1-MPhi and M2-MPhi markers, respectively.	Arginine	43-51	arginase, liver	Mus musculus	124-129
34893540-4	2021	Proteins bearing the R-CO2 N-degron are targeted via Lys48 (K48)-linked ubiquitylation by UBR1/UBR2 N-recognins for proteasomal degradation.	Arginine	21-22	ubiquitin protein ligase E3 component n-recognin 2	Homo sapiens	95-99
32865135-6	2022	One charged mutation that is theorinine 93L to arginine interacting with epitopic glutamic acid 368 strongly contributing in increasing the binding affinity as well as specificity, predicted as -9.6 kcal/mol gain in 2H12-Fab with dengue envelope domain III binding free energy relative to the wild-type.	Arginine	47-55	FA complementation group B	Homo sapiens	221-224
32878247-9	2020	A ubiquitination-defective mutant of SARAF with Lys-to-Arg substitutions in the CytD showed a slower degradation rate by half-life analysis.	Arginine	55-58	store-operated calcium entry associated regulatory factor	Homo sapiens	37-42
34902616-6	2022	Significantly, the reactive oxygen species (ROS) was produced by IA-PEP under 808 nm laser irradiation to perform PDT against tumors, which concurrently reacted with L-Arg to release NO and arouse gas therapy effectively.	Arginine	166-171	prolyl endopeptidase	Mus musculus	68-71
34902616-13	2022	Herein, we developed a nano-vesicle system IA-PEP to integrate photosensitizer PEGylated indocyanine green and L-Arg with high loading content and to produce a ternary synergistic treatment combining NO therapy, photodynamic therapy (PDT) along with mild-temperature photothermal therapy (MPTT) under 808 nm laser irradiation.	Arginine	111-116	prolyl endopeptidase	Mus musculus	46-49
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	COPI coat complex subunit gamma 2	Homo sapiens	25-35
34888656-7	2022	Using a combination of in vitro methylation and cell-based experiments we identified PRMT4 (CARM1) and PRMT6 as major enzymes methylating HTT at specific arginines.	Arginine	154-163	huntingtin	Homo sapiens	138-141
32848891-0	2020	Relationship Between Plasma Osteopontin and Arginine Pathway Metabolites in Patients With Overt Coronary Artery Disease.	Arginine	44-52	secreted phosphoprotein 1	Homo sapiens	28-39
32848891-5	2020	The aim of this study was to better understand the correlations between OPN, oxidative stress markers, and the arginine pathway metabolites.	Arginine	111-119	secreted phosphoprotein 1	Homo sapiens	72-75
34888656-11	2022	Thus, arginine methylation pathways that involve specific HTT-modifying PRMT enzymes and modulate HTT biochemical and toxic properties could provide targets for HD-modifying therapies.	Arginine	6-14	huntingtin	Homo sapiens	58-61
32848891-9	2020	Conclusion: The association between OPN and impaired arginine/NO pathway could play a role in the inhibition of endothelial NO synthase (eNOS) and/or in the arginase activation in the context of CAD patients.	Arginine	53-61	secreted phosphoprotein 1	Homo sapiens	36-39
32848891-10	2020	However, further studies are needed to verify the cause-effect relationship between OPN, oxidative stress, and arginine/NO pathway dysregulation.	Arginine	111-119	secreted phosphoprotein 1	Homo sapiens	84-87
34888656-11	2022	Thus, arginine methylation pathways that involve specific HTT-modifying PRMT enzymes and modulate HTT biochemical and toxic properties could provide targets for HD-modifying therapies.	Arginine	6-14	huntingtin	Homo sapiens	98-101
34944251-3	2021	Skeletal muscle from piglets born from sows from ARG group had greater mRNA expression of MYOD (p = 0.043) and MYOG (p <= 0.01), and tended to present greater mRNA expression (p = 0.06) of IGF-2 gene compared to those born from CON sows.	Arginine	49-52	myogenin	Homo sapiens	111-115
32504080-1	2020	Lysinuric protein intolerance (LPI) is an inborn error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallelic pathogenic variants in SLC7A7, which encodes the light subunit of the y+LAT1 transporter.	Arginine	79-87	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	Mus musculus	161-167
34618055-3	2021	NO-mediated regulation requires efficient sensing via the PROTEOLYSIS6 (PRT6)-mediated proteasome-triggered degradation of group VII of ethylene response transcription factors through the Cys/Arg N-degron pathway.	Arginine	192-195	proteolysis 6	Arabidopsis thaliana	58-70
32724448-8	2020	The results suggested that in individuals with the IRS1 Gly/Arg genotype, the odds of having gastric cancer was increased by 7.891-fold (95% CI: 3.251-19.154, P<0.001) and in individuals with the IRS1 Arg/Arg genotype, it was increased by 22.716-fold (95% CI: 6.311-81.761, P<0.001) compared with those with the IRS1 Gly/Gly genotype.	Arginine	60-63	insulin receptor substrate 1	Homo sapiens	51-55
32724448-8	2020	The results suggested that in individuals with the IRS1 Gly/Arg genotype, the odds of having gastric cancer was increased by 7.891-fold (95% CI: 3.251-19.154, P<0.001) and in individuals with the IRS1 Arg/Arg genotype, it was increased by 22.716-fold (95% CI: 6.311-81.761, P<0.001) compared with those with the IRS1 Gly/Gly genotype.	Arginine	60-63	insulin receptor substrate 1	Homo sapiens	196-200
34618055-3	2021	NO-mediated regulation requires efficient sensing via the PROTEOLYSIS6 (PRT6)-mediated proteasome-triggered degradation of group VII of ethylene response transcription factors through the Cys/Arg N-degron pathway.	Arginine	192-195	proteolysis 6	Arabidopsis thaliana	72-76
32724448-8	2020	The results suggested that in individuals with the IRS1 Gly/Arg genotype, the odds of having gastric cancer was increased by 7.891-fold (95% CI: 3.251-19.154, P<0.001) and in individuals with the IRS1 Arg/Arg genotype, it was increased by 22.716-fold (95% CI: 6.311-81.761, P<0.001) compared with those with the IRS1 Gly/Gly genotype.	Arginine	60-63	insulin receptor substrate 1	Homo sapiens	196-200
32724448-8	2020	The results suggested that in individuals with the IRS1 Gly/Arg genotype, the odds of having gastric cancer was increased by 7.891-fold (95% CI: 3.251-19.154, P<0.001) and in individuals with the IRS1 Arg/Arg genotype, it was increased by 22.716-fold (95% CI: 6.311-81.761, P<0.001) compared with those with the IRS1 Gly/Gly genotype.	Arginine	201-204	insulin receptor substrate 1	Homo sapiens	51-55
34791230-5	2022	First, we show in C2C12 myoblasts, that arginine methylation by CARM1 controls myogenic differentiation.	Arginine	40-48	coactivator-associated arginine methyltransferase 1	Mus musculus	64-69
32724448-8	2020	The results suggested that in individuals with the IRS1 Gly/Arg genotype, the odds of having gastric cancer was increased by 7.891-fold (95% CI: 3.251-19.154, P<0.001) and in individuals with the IRS1 Arg/Arg genotype, it was increased by 22.716-fold (95% CI: 6.311-81.761, P<0.001) compared with those with the IRS1 Gly/Gly genotype.	Arginine	201-204	insulin receptor substrate 1	Homo sapiens	51-55
34758320-5	2021	Substituting the two residues, Lys49 and Lys124, with arginines abrogates proper CENP-A degradation and results in CENP-A mislocalization to non-centromeric regions.	Arginine	54-63	centromere protein A	Homo sapiens	81-87
32709847-2	2020	E2F1 is the major target through which pRb exerts its effects and arginine methylation by PRMT5 plays a key role in dictating E2F1 activity.	Arginine	66-74	E2F transcription factor 1	Homo sapiens	126-130
34758320-5	2021	Substituting the two residues, Lys49 and Lys124, with arginines abrogates proper CENP-A degradation and results in CENP-A mislocalization to non-centromeric regions.	Arginine	54-63	centromere protein A	Homo sapiens	115-121
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	clusterin	Homo sapiens	46-49
34433661-4	2021	NEI-01, a novel arginine-depleting enzyme, is capable of binding to serum albumin to extend its circulating half-life, leading to a potent anticancer activity.	Arginine	16-24	albumin	Mus musculus	68-81
34583098-10	2021	Arginine methylation of TLR4 on R812 or PRMT2 enhanced interferon-beta (IFN-beta) production.	Arginine	0-8	interferon beta 1	Homo sapiens	55-70
34762361-2	2021	PH is reduced and NO signaling is improved in chronically hypoxic piglets treated with the NO-arginine precursor, L-citrulline.	Arginine	94-102	phenylalanine hydroxylase	Homo sapiens	0-2
34255889-3	2021	We identified SNPs in FCGR2A (131 histidine (H) or arginine (R); rs1801274) and reviewed the infectious complication-free survival after ICU discharge.	Arginine	51-59	Fc gamma receptor IIa	Homo sapiens	22-28
34520398-2	2021	Myeloid cell expression of arginase 1 (Arg-1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular L-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understood.	Arginine	134-144	arginase, liver	Mus musculus	27-37
32766249-0	2020	Arg-GlcNAcylation on TRADD by NleB and SseK1 Is Crucial for Bacterial Pathogenesis.	Arginine	0-3	TNFRSF1A-associated via death domain	Mus musculus	21-26
32553119-2	2020	ATE1 utilizes arginyl (Arg)-tRNAArg as the donor of Arg, putting this reaction into a direct competition with the protein synthesis machinery.	Arginine	23-26	arginyltransferase 1	Homo sapiens	0-4
33005891-3	2020	Most of the mutations are substitutions to a non-charged residue, from the positively charged arginine (R) in transmembrane segment 4 (S4) of a voltage sensor in either CaV1.1 or NaV1.4.	Arginine	94-102	sodium voltage-gated channel alpha subunit 4	Homo sapiens	179-185
32754051-5	2020	L-arginine treatment during 7 days of rat HS prevented HS-induced NO content decrease and slow MyHC mRNA transcription decrease and attenuated fast MyHC IIb mRNA transcription increase; it also prevented NFATc1 nuclear content decrease, calsarcin-2 expression increase, and GSK-3beta Ser 9 phosphorylation decrease.	Arginine	0-10	nuclear factor of activated T-cells 1	Rattus norvegicus	204-210
32754051-6	2020	Moreover, L-arginine administration prevented the HS-induced myh7b and PGC1alpha mRNAs content decreases and slow-type genes repressor SOX6 mRNA transcription increase.	Arginine	10-20	myosin heavy chain 7B	Rattus norvegicus	61-66
32620797-0	2020	C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.	Arginine	8-16	UPF1 RNA helicase and ATPase	Homo sapiens	48-52
32620797-3	2020	Here, we show that RNA decay mechanisms involving upstream frameshift 1 (UPF1), including nonsense-mediated decay (NMD), are inhibited in c9ALS/FTD brains and in cultured cells expressing either of two arginine-rich dipeptide repeats (R-DPRs), poly(GR) and poly(PR).	Arginine	202-210	UPF1 RNA helicase and ATPase	Homo sapiens	50-71
32620797-3	2020	Here, we show that RNA decay mechanisms involving upstream frameshift 1 (UPF1), including nonsense-mediated decay (NMD), are inhibited in c9ALS/FTD brains and in cultured cells expressing either of two arginine-rich dipeptide repeats (R-DPRs), poly(GR) and poly(PR).	Arginine	202-210	UPF1 RNA helicase and ATPase	Homo sapiens	73-77
32642843-0	2020	Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells.	Arginine	27-35	PGP	Canis lupus familiaris	117-131
34520398-2	2021	Myeloid cell expression of arginase 1 (Arg-1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular L-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understood.	Arginine	134-144	arginase, liver	Mus musculus	39-44
34681616-3	2021	Specifically, the failure of A-to-I RNA editing at the glutamine/arginine (Q/R) site of the GluA2 subunit causes excessive permeability of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors to Ca2+, inducing fatal status epilepticus and the neurodegeneration of motor neurons in mice.	Arginine	65-73	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	92-97
34611176-1	2021	In this work, graphitic carbon nitride-supported L-arginine (g-C3N4@L-arginine) nanocatalyst was synthesized and evaluated using FT-IR, EDX, XRD, TGA, and FESEM analyses.	Arginine	49-59	T-box transcription factor 1	Homo sapiens	146-149
34611176-1	2021	In this work, graphitic carbon nitride-supported L-arginine (g-C3N4@L-arginine) nanocatalyst was synthesized and evaluated using FT-IR, EDX, XRD, TGA, and FESEM analyses.	Arginine	68-78	T-box transcription factor 1	Homo sapiens	146-149
34560100-7	2021	We also note a correlation between the presence of ancestral ODC and ornithine/arginine auxotrophy, and link this with a known symbiotic dependence on exogenous ornithine produced by species using the arginine deiminase system.	Arginine	79-87	ornithine decarboxylase 1	Homo sapiens	61-64
34450641-5	2021	Two arginine residues within the GATA-1 linker region mediates direct interaction with HDAC1.	Arginine	4-12	GATA binding protein 1	Mus musculus	33-39
34450641-6	2021	The arginine to alanine mutation (2RA) blocks GATA-1 deacetylation and fails to induce erythroid differentiation.	Arginine	4-12	GATA binding protein 1	Mus musculus	46-52
34415722-5	2021	Here, we solved the X-ray structures of furin in complex with four different arginine mimetic compounds with reduced basicity.	Arginine	77-85	furin, paired basic amino acid cleaving enzyme	Homo sapiens	40-45
34576162-0	2021	TAR RNA Mediated Folding of a Single-Arginine-Mutant HIV-1 Tat Protein within HeLa Cells Experiencing Intracellular Crowding.	Arginine	37-45	tyrosine aminotransferase	Homo sapiens	59-62
34576163-2	2021	In our previous studies, we reported the robust neuroprotective effects of the icosamer OPN peptide OPNpt20, containing arginine-glycine-aspartic acid (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs, in an animal model of transient focal ischemia and demonstrated that its anti-inflammatory, pro-angiogenic, and phagocytosis inducing functions are responsible for the neuroprotective effects.	Arginine	120-128	secreted phosphoprotein 1	Rattus norvegicus	88-91
34489423-0	2021	C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers.	Arginine	16-24	C9orf72-SMCR8 complex subunit	Homo sapiens	0-7
34489423-2	2021	Toxic arginine-rich poly-dipeptides from C9orf72 interact with NIRs and cause nucleocytoplasmic transport deficit.	Arginine	6-14	C9orf72-SMCR8 complex subunit	Homo sapiens	41-48
34500630-7	2021	Further investigations demonstrated that a cluster of arginines in the C-terminus of MLKL2-154 is important for the molecular conformational switch.	Arginine	54-63	mixed lineage kinase domain like pseudokinase	Homo sapiens	85-89
34500630-8	2021	Functional mutagenesis showed that mutating these arginines to glutamates hindered the membrane disruption of full-length MLKL and thus inhibited the necroptotic cell death.	Arginine	50-59	mixed lineage kinase domain like pseudokinase	Homo sapiens	122-126
34147573-9	2021	The peptide-based gene carrier created by conjugating positively-charged nine arginine (9R) and the TKPR (Thr-Lys-Pro-Arg) sequence from the Fc region of Immunoglobulin G (IgG) specifically binds to the neuropilin-1 (NRP-1) receptor on the macrophage surface.	Arginine	78-86	neuropilin 1	Homo sapiens	203-215
34137511-5	2021	Under the coating of PLPs, mesoporous silica nanospheres with a payload of miR-21, an anti-inflammatory agent, can be specifically delivered to inflammatory monocytes in the blood circulation of MI/R induced mice.	Arginine	198-199	microRNA 21a	Mus musculus	75-81
34367736-4	2021	We observed that tumor progression is associated with an incremental increase in the number of Arg1+ myeloid cells that accumulate in the tumor microenvironment and cause systemic depletion of L-arginine.	Arginine	193-203	arginase 1	Homo sapiens	95-99
34210977-7	2021	A dual-arginine-anchor motif of ALC1 recognizes the acidic pocket of the nucleosome, which is critical for chromatin remodeling in vitro.	Arginine	7-15	chromodomain helicase DNA binding protein 1 like	Homo sapiens	32-36
34097379-9	2021	Our sensing system employed one-step FRET-based ZFP and GO combined technology to enable rapid and quantitative detection of ARG, providing a limit of detection as low as 1 nM.	Arginine	125-128	zinc finger with KRAB and SCAN domains 7	Homo sapiens	48-51
34222255-5	2021	Here, we demonstrate that endothelial dysfunction resulting from knockout of both Rap1A and Rap1B isoforms is ameliorated by exogenous L-Arg administration to rescue NO-dependent vasorelaxation and blood pressure.	Arginine	135-140	RAP1B, member of RAS oncogene family	Homo sapiens	92-97
34162039-6	2021	PXXP and BAG domains of BAG3 played an essential role in BAG3 attenuating cardiomyocytes apoptosis induced by H/R through the JNK signalling pathway.	Arginine	112-113	BAG cochaperone 3	Rattus norvegicus	24-28
34162039-6	2021	PXXP and BAG domains of BAG3 played an essential role in BAG3 attenuating cardiomyocytes apoptosis induced by H/R through the JNK signalling pathway.	Arginine	112-113	BAG cochaperone 3	Rattus norvegicus	57-61
34162039-8	2021	These results showed that the protective effect of BAG3 on apoptosis induced by H/R stress is closely related to its structural domains PXXP and BAG.	Arginine	82-83	BAG cochaperone 3	Rattus norvegicus	51-55
34095122-5	2021	Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism.	Arginine	130-138	ornithine decarboxylase 1	Homo sapiens	75-98
34095122-5	2021	Endothelial nitric oxide synthase (eNOS), argininosuccinate synthetase and ornithine decarboxylase (ODC) are the main enzymes for arginine metabolism.	Arginine	130-138	ornithine decarboxylase 1	Homo sapiens	100-103
34095139-8	2021	In this article, we describe the population genetics and spread of the original arginine-to-glutamine mutation at position 51 (R51Q) in SNX10 in the Palestinian community.	Arginine	80-88	sorting nexin 10	Homo sapiens	136-141
34123401-6	2021	A high arginine level and arginine/ADMA ratio were significantly associated with lower CCL-20 and TNF-alpha levels.	Arginine	7-15	C-C motif chemokine ligand 20	Homo sapiens	87-93
34123401-6	2021	A high arginine level and arginine/ADMA ratio were significantly associated with lower CCL-20 and TNF-alpha levels.	Arginine	26-34	C-C motif chemokine ligand 20	Homo sapiens	87-93
35276003-6	2022	Serine/arginine-rich splicing factors, which are involved in pre-mRNA splicing by interacting with MALAT1, reside in nuclear speckles in wild-type and diabetic DRG neurons; MALAT1 silencing was associated with their disruption.	Arginine	7-15	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	99-105
32591537-5	2020	Here, we report that PAD4 antagonizes histone MGO-glycation by protecting the reactive arginine sites, as well as by converting already-glycated arginine residues into citrulline.	Arginine	87-95	peptidyl arginine deiminase 4	Homo sapiens	21-25
32591537-5	2020	Here, we report that PAD4 antagonizes histone MGO-glycation by protecting the reactive arginine sites, as well as by converting already-glycated arginine residues into citrulline.	Arginine	145-153	peptidyl arginine deiminase 4	Homo sapiens	21-25
35276003-6	2022	Serine/arginine-rich splicing factors, which are involved in pre-mRNA splicing by interacting with MALAT1, reside in nuclear speckles in wild-type and diabetic DRG neurons; MALAT1 silencing was associated with their disruption.	Arginine	7-15	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	173-179
32199949-1	2020	Protein arginine methyltransferase 1 (PRMT1) and the product of this enzyme (histone H4 asymmetrically dimethylated at Arg 3; H4R3me2a) are important in the establishment and maintenance of chicken and murine erythrocyte transcriptionally active chromatin.	Arginine	119-122	protein arginine N-methyltransferase 1	Mus musculus	38-43
35231586-0	2022	Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibody.	Arginine	12-34	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	170-175
32430022-7	2020	RESULTS: The carriers of the C allele (Arg at 64th position was encoded by the C allele) had higher levels of leptin and lower levels of adiponectin than the non-carriers.	Arginine	39-42	leptin	Homo sapiens	110-116
35621373-3	2022	Tat peptide has a large number of basic arginines and a couple of polar glutamines.	Arginine	40-49	tyrosine aminotransferase	Homo sapiens	0-3
32420474-0	2020	Protein arginine methyltransferase 6 mediates cardiac hypertrophy by differential regulation of histone H3 arginine methylation.	Arginine	8-16	relaxin 3	Homo sapiens	104-106
32420474-6	2020	These changes are associated with a significant increase in arginine 2 asymmetric methylation of histone H3 (H3R2Me2a) and reduced lysine 4 tri-methylation of H3 (H3K4Me3) observed both in NRVM and in vivo.	Arginine	60-68	relaxin 3	Homo sapiens	105-107
32420474-6	2020	These changes are associated with a significant increase in arginine 2 asymmetric methylation of histone H3 (H3R2Me2a) and reduced lysine 4 tri-methylation of H3 (H3K4Me3) observed both in NRVM and in vivo.	Arginine	60-68	relaxin 3	Homo sapiens	109-111
35583632-2	2022	Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which moderates the activity of splicing factors rich in serine/arginine domains.	Arginine	118-126	SRSF protein kinase 1	Homo sapiens	0-32
32115146-6	2020	These Arntl-deficient mice developed l-arginine-induced acute pancreatitis more rapidly than controls, with increased mortality, tissue injury, neutrophil infiltration, and HMGB1 release.	Arginine	37-47	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	6-11
35583632-2	2022	Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which moderates the activity of splicing factors rich in serine/arginine domains.	Arginine	118-126	SRSF protein kinase 1	Homo sapiens	34-39
35561872-11	2022	CONCLUSION: Competitive athletes who undergo primary hip arthroscopy with R demonstrated significantly greater magnitude of improvement in PROs (NAHS, HOS-SSS, VAS) and rates of achieving MCID (HOS-SSS) compared to a propensity-matched control group of competitive athletes with an UR.	Arginine	74-75	hedgehog interacting protein	Homo sapiens	53-56
32435206-1	2020	Arginyltransferase1 (ATE1) is a conserved enzyme in eukaryotes mediating posttranslational arginylation, the addition of an extra arginine to an existing protein.	Arginine	130-138	arginyltransferase 1	Homo sapiens	21-25
35434944-11	2022	Mechanistically, HSF1 interacted with protein arginine methyltransferase 5 (PRMT5) and jointly induced the monomethylation of histone H3 at arginine 2 (H3R2me1) and symmetric dimethylation of histone H3 at arginine 2 (H3R2me2s).	Arginine	140-148	heat shock transcription factor 1	Homo sapiens	17-21
32193354-1	2020	Peptidyl arginine deiminase 4 (PAD4/PADI4) is a posttranslational modification enzyme that converts protein arginine or mono-methylarginine to citrulline.	Arginine	9-17	MMTV LTR integration site 4	Mus musculus	31-35
35434944-11	2022	Mechanistically, HSF1 interacted with protein arginine methyltransferase 5 (PRMT5) and jointly induced the monomethylation of histone H3 at arginine 2 (H3R2me1) and symmetric dimethylation of histone H3 at arginine 2 (H3R2me2s).	Arginine	206-214	heat shock transcription factor 1	Homo sapiens	17-21
32193354-1	2020	Peptidyl arginine deiminase 4 (PAD4/PADI4) is a posttranslational modification enzyme that converts protein arginine or mono-methylarginine to citrulline.	Arginine	9-17	peptidyl arginine deiminase, type IV	Mus musculus	36-41
35475645-4	2022	Reverse transcription-PCR (RT-PCR) studies found that mutations within ccpA or ahrC or SNPs identified upstream of arcA1B1D1C1 increased the transcription of both arcB1 and argGH, encoding ornithine carbamoyltransferase and argininosuccinate synthase/lyase, respectively, facilitating arginine biosynthesis.	Arginine	285-293	AT695_RS12930	Staphylococcus aureus	224-250
32366039-4	2020	SseK1 catalyzed the addition of N-acetylglucosamine to arginine on TBCB, and its expression promoted the stabilization of the microtubule cytoskeleton of HEK293T cells.	Arginine	55-63	tubulin folding cofactor B	Homo sapiens	67-71
35470495-6	2022	Compared to the control group, the anti-inflammatory action of l-arginine is reflected by upregulation of hepatic interleukin-10 (IL-10) and the suppression of hepatic cyclooxygenase-2, tumor necrotic factor alpha, IL-1beta, and IL-6 expressions in growing rats.	Arginine	63-73	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	168-184
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Arginine	101-109	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	147-152
35458513-3	2022	Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors.	Arginine	101-109	angiotensin converting enzyme 2	Homo sapiens	298-302
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	66-70
32391010-4	2020	IL-17A levels reduced but IL-17F levels increased significantly in the colorectum of Arg myeKO mice, leading to severe tissue damage and high risk of mortality rate.	Arginine	85-88	interleukin 17F	Mus musculus	26-32
35458513-5	2022	Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2.	Arginine	11-19	angiotensin converting enzyme 2	Homo sapiens	194-198
35458513-6	2022	However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations.	Arginine	36-44	angiotensin converting enzyme 2	Homo sapiens	161-165
35322764-4	2022	Many developed nNOS inhibitors, generally L-arginine mimetics, have some issues in selectivity and bioavailability.	Arginine	42-52	nitric oxide synthase 1	Homo sapiens	15-19
32316396-7	2020	KEGG and pathway enrichment analyses of those urinary metabolites, and the Person"s correlation analyses among those urinary metabolites and bone status revealed that LF impacted on bone formation via regulatory comprehensive pathways including taurine and hypotaurine metabolism, arginine and proline metabolism, cyanoamino acid metabolism, nitrogen metabolism, nicotinate and nicotinamide metabolism, and fatty acid biosynthesis.	Arginine	281-289	lactotransferrin	Rattus norvegicus	167-169
35149195-3	2022	This study involved 453 patients with severe COVID-19, in which the FCGR2A rs1801274 G-allele (131-Arg) was significantly associated with death (p = 0.02, OR = 1.47).	Arginine	99-102	Fc gamma receptor IIa	Homo sapiens	68-74
32094223-6	2020	To elucidate the biological consequences of IQGAP1 ubiquitination, we converted each of these lysines to arginine and found that replacing two of these residues, Lys-1155 and Lys-1230, in the GAP-related domain of IQGAP1 (termed IQGAP1 GRD-2K) reduces its ubiquitination.	Arginine	105-113	IQ motif containing GTPase activating protein 1	Homo sapiens	44-50
35137449-3	2022	UBA6-AS1 was preferentially induced in triple-negative BC (TNBC) cells deprived of arginine or glutamine, two critical amino acids required for cancer cell growth, or treated with ER stress inducers.	Arginine	83-91	prostaglandin D2 receptor	Homo sapiens	5-8
32277160-8	2020	The neural ERbeta is thus involved to different extent levels in social and mood-related behaviors, with a particular action on oxytocin and arginine-vasopressin signaling pathways of the bed nucleus of stria terminalis, yet the involvement of other brain areas cannot be excluded.	Arginine	141-149	estrogen receptor 1 (alpha)	Mus musculus	11-17
32265459-6	2020	Met-predictor was tested on two independent test sets, where the addition of structure model-based features improved AUC from 0.611 and 0.520 to 0.655 and 0.566 for lysine and from 0.723 and 0.640 to 0.734 and 0.643 for arginine.	Arginine	220-228	SAFB like transcription modulator	Homo sapiens	0-3
32169720-6	2020	l-Arginine also reduces the over-expression of inflammatory molecules induced by LPS (TNF-alpha, IL-6 and IL-1beta, p < 0.001).	Arginine	0-10	tumor necrosis factor	Bos taurus	86-95
31779731-3	2020	Results showed that dietary supplementation of 1 0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group.	Arginine	53-56	troponin I1, slow skeletal type	Homo sapiens	255-260
31779731-3	2020	Results showed that dietary supplementation of 1 0 % Arg significantly enhanced the activity of succinate dehydrogenase, up-regulated the protein expression of myosin heavy chain I (MyHC I) and increased the mRNA levels of MyHC I, troponin I1, C1 and T1 (Tnni1, Tnnc1 and Tnnt1) in longissimus dorsi muscle compared with the control group.	Arginine	53-56	troponin T1, slow skeletal type	Homo sapiens	272-277
32181366-5	2020	In contrast, two related SAK1 toxins, Hui1 and ShK, block KcsA and Kv1.3, respectively, via an arginine rather than the canonical lysine, when tethered and as free peptides.	Arginine	95-103	sedoheptulokinase	Homo sapiens	47-50
32490317-3	2020	Protein arginine methyltransferase 1 (PRMT1) is the main enzyme responsible for cellular arginine methylation.	Arginine	8-16	protein arginine N-methyltransferase 1	Mus musculus	38-43
32090093-0	2020	L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221.	Arginine	0-10	microRNA 221	Homo sapiens	79-86
32090093-6	2020	Results: The results suggested that L-arginine could prevent oxidized low-density lipoprotein-induced apoptosis in endothelial cells, which is associated with the downregulation of miR-221.	Arginine	36-46	microRNA 221	Homo sapiens	181-188
31571563-7	2020	Compared with the Control, the infusion of Arg led to greater concentrations of total protein, immunoglobulin M and high density lipoprotein cholesterol coupled with lower concentrations of haptoglobin and tumor necrosis factor-alpha, and activity of aspartate aminotransferase in serum.	Arginine	43-46	tumor necrosis factor	Bos taurus	206-233
31000813-7	2020	PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2.	Arginine	44-52	protein arginine N-methyltransferase 7	Mus musculus	0-5
32993399-7	2020	Knockdown of ANGPTL2 improved the decreased cell viability of HK-2 cells in response to H/R stimulation.	Arginine	90-91	angiopoietin like 2	Homo sapiens	13-20
33148838-5	2020	RESULTS: Results: It has been established that individuals with mutant genotypes Arg/Gln of TLR-2, Leu/Phe, Phe/Phe of TLR-3, Asp/Gly of TLR-4 genes have a vaccinal response to administering anti-influenza vaccine at the level of subjects with normal distribution of TLR alleles, as evidenced by the growth in dynamics of mean geometric titers of antibodies to vaccine strains, the level of seroprotection and seroconversion.	Arginine	81-84	assembly factor for spindle microtubules	Homo sapiens	126-129
33148838-5	2020	RESULTS: Results: It has been established that individuals with mutant genotypes Arg/Gln of TLR-2, Leu/Phe, Phe/Phe of TLR-3, Asp/Gly of TLR-4 genes have a vaccinal response to administering anti-influenza vaccine at the level of subjects with normal distribution of TLR alleles, as evidenced by the growth in dynamics of mean geometric titers of antibodies to vaccine strains, the level of seroprotection and seroconversion.	Arginine	81-84	toll like receptor 4	Homo sapiens	137-142
31189070-2	2019	SLC6A14-mediated l-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract.	Arginine	17-27	solute carrier family 6 (neurotransmitter transporter), member 14	Mus musculus	0-7
31655981-4	2019	Three hydrophilic amino acids [arginine (ARG), asparagine (ASN) and aspartic acid (ASP)] play important roles in the antibacterial effects of quinolones.	Arginine	31-39	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	41-44
31395686-2	2019	Deficiency of argininosuccinate synthetase-1 (ASS1) in pancreatic cancers creates auxotrophy for the semiessential amino acid arginine.	Arginine	126-134	argininosuccinate synthase 1	Homo sapiens	14-44
31395686-2	2019	Deficiency of argininosuccinate synthetase-1 (ASS1) in pancreatic cancers creates auxotrophy for the semiessential amino acid arginine.	Arginine	126-134	argininosuccinate synthase 1	Homo sapiens	46-50
31576512-16	2019	L-Arginine and AICAR also upregulated the mRNA expression level of HSP70 and HSP90, and downregulated mRNA expression of MLCK (P < 0.05).	Arginine	0-10	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	67-72
31576512-17	2019	The protein expression levels of TJ proteins ZO-1 and claudin-1 were suppressed by heat stroke and dorsomorphin, but enhanced by L-arginine and AICAR.	Arginine	129-139	tight junction protein 1	Rattus norvegicus	45-49
31496325-11	2019	Meanwhile, OMT inhibited Arg-induced expression of CD44 and CD55 in intestinal injury.	Arginine	25-28	CD44 molecule (Indian blood group)	Rattus norvegicus	51-55
31768260-14	2019	Structure-directed mutagenesis indicates a critical role for arginine at position 203 in transmembrane domain 5 to mediate GPR132 activation by N-acylamides.	Arginine	61-69	G protein-coupled receptor 132	Homo sapiens	123-129
31922465-9	2019	This meta-analysis concludes that l-arginine supplementation can significantly reduce blood TAG levels; however, there is insufficient evidence to support its hypocholesterolaemic effects.	Arginine	34-44	long intergenic non-protein coding RNA 1194	Homo sapiens	92-95
31373778-1	2019	HLA-B*51:01:41 has one synonymous nucleotide change from HLA-B*51:01:01:01 at nucleotide 216 (codon 48 arginine).	Arginine	103-111	major histocompatibility complex, class I, B	Homo sapiens	0-5
31373778-1	2019	HLA-B*51:01:41 has one synonymous nucleotide change from HLA-B*51:01:01:01 at nucleotide 216 (codon 48 arginine).	Arginine	103-111	major histocompatibility complex, class I, B	Homo sapiens	57-62
31444697-2	2019	We aimed to investigate the predictive value of arginine and its metabolites for diagnosing prostate cancer in patients with PSA 4-10 ng/ml and evaluate their usefulness as prognostic tumor markers.	Arginine	48-56	kallikrein related peptidase 3	Homo sapiens	125-128
31519807-3	2019	Here, we show that knockdown of the Drosophila lncRNA hsromega causes a shift in the methylation status of human FUS from mono- (MMA) to di-methylated (DMA) arginine via upregulation of the arginine methyltransferase 5 (PRMT5, known as ART5 in flies).	Arginine	157-165	ADP-ribosyltransferase 5	Homo sapiens	236-240
31473880-9	2019	Ectopic expression of non-methylatable hnRNP A1 mutants demonstrated that methylation of either arginine residues 218 or 225 was sufficient to maintain IRES binding and hnRNP A1-dependent cyclin D1 or c-MYC IRES activity, however a double R218K/R225K mutant was unable to do so.	Arginine	96-104	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	201-206
35214759-5	2022	The study further shows the formation of dynamically interchangeable and persistent networks of salt-bridges at the Spike-Furin interface in SARS-CoV-2 involving the three arginines (R682, R683, R685) of the FLCSSpike with several anionic residues (E230, E236, D259, D264, D306) coming from Furin, strategically distributed around its catalytic triad.	Arginine	172-181	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	116-121
31376587-8	2019	RESULTS: PFD suppressed the development of l-arginine-induced AP as revealed by the improvement of histopathological lesions of pancreatic specimen and the significant reduction of serum amylase and lipase levels.	Arginine	43-53	lipase, endothelial	Mus musculus	199-205
35214759-5	2022	The study further shows the formation of dynamically interchangeable and persistent networks of salt-bridges at the Spike-Furin interface in SARS-CoV-2 involving the three arginines (R682, R683, R685) of the FLCSSpike with several anionic residues (E230, E236, D259, D264, D306) coming from Furin, strategically distributed around its catalytic triad.	Arginine	172-181	furin, paired basic amino acid cleaving enzyme	Homo sapiens	122-127
35214759-5	2022	The study further shows the formation of dynamically interchangeable and persistent networks of salt-bridges at the Spike-Furin interface in SARS-CoV-2 involving the three arginines (R682, R683, R685) of the FLCSSpike with several anionic residues (E230, E236, D259, D264, D306) coming from Furin, strategically distributed around its catalytic triad.	Arginine	172-181	furin, paired basic amino acid cleaving enzyme	Homo sapiens	291-296
31616317-2	2019	Recently, it was shown that L-arginine administration prevented the decrease in levels of the muscle cytoskeletal proteins, desmin and dystrophin, in rat soleus muscle after 14 days of hindlimb unloading.	Arginine	28-38	dystrophin	Rattus norvegicus	135-145
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	valosin containing protein	Homo sapiens	267-274
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	STIP1 homology and U-box containing protein 1	Homo sapiens	395-400
31446431-3	2019	Here we found that Abeta peptides inhibited the proteolytic activity of the antiapoptotic Arg/N-end rule pathway that is a part of UPS.	Arginine	90-93	amyloid beta (A4) precursor protein	Mus musculus	19-24
35491020-4	2022	Complexation of ConA and CD206 with ligands is shown to be energetically caused by electrostatic interactions (E) of the charged residues (Asn, Asp, Arg) with oxygen and hydrogen atoms in carbohydrates; contributions of hydrophobic and van der Waals components is lower.	Arginine	149-152	mannose receptor C-type 1	Homo sapiens	25-30
31446431-5	2019	Abeta bearing the familial English H6R mutation, known to cause early-onset AD, had an even greater inhibitory effect on protein degradation through the Arg/N-end rule pathway than intact Abeta.	Arginine	153-156	amyloid beta (A4) precursor protein	Mus musculus	0-5
31446431-8	2019	Together, our results show that the apoptotic effect of Abeta peptides is linked to their impairment of Ate1 catalytic activity leading to suppression of the Arg/N-end rule pathway proteolytic activity and ultimately cell death.	Arginine	158-161	amyloid beta (A4) precursor protein	Mus musculus	56-61
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	40-43	plasminogen activator, urokinase receptor	Homo sapiens	94-98
35022194-6	2022	RESULTS: PDAC progression is marked by a stepwise infiltration of myeloid cells, which enforces a highly immunosuppressive microenvironment through the uncontrolled metabolism of L-arginine by arginase 1 and inducible nitric oxide synthase activity, resulting in the production of large amounts of reactive oxygen and nitrogen species.	Arginine	179-189	arginase 1	Homo sapiens	193-203
35281666-1	2022	Arginase deficiency is a rare autosomal recessive urea cycle disorder (UCD) caused by mutations in the ARG1 gene encoding arginase that catalyses the hydrolysis of arginine to ornithine and urea.	Arginine	164-172	arginase 1	Homo sapiens	103-107
31434916-1	2019	The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration.	Arginine	48-51	plasminogen activator, urokinase receptor	Homo sapiens	94-98
2620324-1	1989	Endothelium derived relaxing factor (EDRF) has been identified as nitric oxide, synthesised from the amino acid L-arginine, a process which is inhibited by the L-arginine analogue NG-monomethyl L-arginine (L-NMMA).	Arginine	112-122	alpha hemoglobin stabilizing protein	Homo sapiens	0-35
31399282-2	2019	Two L-arginine catalytic enzymes, iNOS and arginase 1, are well-characterized hallmark molecules of classically and alternatively activated macrophages, respectively.	Arginine	4-14	inositol-3-phosphate synthase 1	Homo sapiens	34-38
31481945-4	2019	We found that arsC and ereA genes coding for resistance mechanisms to arsenic and to macrolides, respectively, are the most abundant MRG and ARG in the study area.	Arginine	141-144	steroid sulfatase	Homo sapiens	14-18
31186139-2	2019	In the present study, we designed a human H2A.Z.1(S42R) mutant, in which the Ser42 residue is replaced by Arg.	Arginine	106-109	H2A.Z variant histone 1	Homo sapiens	42-49
31186139-3	2019	In the crystal structure of the nucleosome containing H2A.Z.1(S42R), the Arg residue inserted at the H2A.Z.1-Ser42 position forms additional hydrogen bonds and electrostatic interactions with the DNA backbone phosphates.	Arginine	73-76	H2A.Z variant histone 1	Homo sapiens	54-61
31186139-3	2019	In the crystal structure of the nucleosome containing H2A.Z.1(S42R), the Arg residue inserted at the H2A.Z.1-Ser42 position forms additional hydrogen bonds and electrostatic interactions with the DNA backbone phosphates.	Arginine	73-76	H2A.Z variant histone 1	Homo sapiens	101-108
31230549-1	2019	Human blood pressure salt sensitivity is associated with changes in urinary metabolites related to fumarase (Fh) and nitric oxide (NO) metabolism, and fumarase promotes NO production through an arginine regeneration pathway.	Arginine	194-202	fumarate hydratase	Rattus norvegicus	151-159
31093850-0	2019	Impaired L-arginine metabolism marks endothelial dysfunction in CD73-deficient mice.	Arginine	9-19	5' nucleotidase, ecto	Mus musculus	64-68
31093850-8	2019	All CD73-/- mice age groups were characterized by reduced L-Arginine concentration and eNOS level.	Arginine	58-68	5' nucleotidase, ecto	Mus musculus	4-8
31093850-10	2019	The L-Arginine/ADMA ratio in the CD73-/- decreased in age-dependent manner in comparison to WT.	Arginine	4-14	5' nucleotidase, ecto	Mus musculus	33-37
31093850-14	2019	The CD73 deletion leads to the development of age-dependent endothelial dysfunction in mice, associated with impaired L-arginine metabolism.	Arginine	118-128	5' nucleotidase, ecto	Mus musculus	4-8
31417867-5	2019	In addition, six genes including ODC1, SMS, SRM, RRM2, SMOX, and SAT1 associated with arginine and proline metabolism were found to be key players in this metabolic alteration.	Arginine	86-94	ribonucleotide reductase regulatory subunit M2	Homo sapiens	49-53
31101333-1	2019	Arginine is a semi-essential amino acid with multiple functions, including stimulating the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).	Arginine	0-8	growth hormone	Mus musculus	104-118
31101333-1	2019	Arginine is a semi-essential amino acid with multiple functions, including stimulating the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).	Arginine	0-8	growth hormone	Mus musculus	120-122
31101333-3	2019	Previous studies showed that arginine-induced IGF-1 secretion occurs via two pathways: a GH-dependent pathway and an arginine-dependent pathway with an unknown mechanism.	Arginine	29-37	growth hormone	Mus musculus	89-91
31235809-1	2019	Protein Arginine methyltransferase 1 (PRMT1) is the main enzyme of cellular arginine methylation.	Arginine	76-84	protein arginine N-methyltransferase 1	Mus musculus	0-36
31235809-1	2019	Protein Arginine methyltransferase 1 (PRMT1) is the main enzyme of cellular arginine methylation.	Arginine	76-84	protein arginine N-methyltransferase 1	Mus musculus	38-43
30861422-5	2019	To antagonize intracellular MDM2/MDMX for p53 activation, we extended this protein, PMIBcr/Abl, by a C-terminal Arg-repeating hexapeptide to facilitate its cellular uptake.	Arginine	112-115	MDM4 regulator of p53	Homo sapiens	33-37
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	H2B clustered histone 21	Homo sapiens	74-77
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	H2B clustered histone 21	Homo sapiens	135-138
30923167-2	2019	Here, we present cryo-EM structures of DOT1L complexes with unmodified or H2B ubiquitinated nucleosomes, showing that DOT1L recognizes H2B ubiquitin and the H2A/H2B acidic patch through a C-terminal hydrophobic helix and an arginine anchor in DOT1L, respectively.	Arginine	224-232	H2B clustered histone 21	Homo sapiens	135-138
31081413-6	2019	We evaluated the relationship between levels of l-arginine and arginine decarboxylase in the agmatine synthesis pathway, and level of agmatinase that degrades agmatine.	Arginine	48-58	antizyme inhibitor 2	Homo sapiens	63-85
31107867-6	2019	In addition, structural and biochemical analysis show that the C-terminal region of Chz1 (Chz1-C) harbors a conserved DEF/Y motif, which reflects the consecutive D/E residues followed by a single aromatic residue, to engage an arginine finger and a hydrophobic pocket in H2A.Z-H2B, enhancing the binding preference for H2A.Z-H2B.	Arginine	227-235	Chz1p	Saccharomyces cerevisiae S288C	84-88
31107867-6	2019	In addition, structural and biochemical analysis show that the C-terminal region of Chz1 (Chz1-C) harbors a conserved DEF/Y motif, which reflects the consecutive D/E residues followed by a single aromatic residue, to engage an arginine finger and a hydrophobic pocket in H2A.Z-H2B, enhancing the binding preference for H2A.Z-H2B.	Arginine	227-235	Chz1p	Saccharomyces cerevisiae S288C	90-96
31064153-2	2019	In our previous works, we have obtained several submicromolar inhibitors of this interaction, including branched pentapeptides of general structure Lys(Har)-Xxx-Xxx-Arg.	Arginine	165-168	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	152-155
31064153-6	2019	The inhibitory activity of the synthesized derivatives spans from 9.2% to 58.1% at 10 muM concentration (the best compound Lys(Har)-GlyPsi[Trl]GlyPsi[Trl]Arg, 3, IC50 = 8.39 muM).	Arginine	154-157	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	127-130
31069272-4	2019	Here we show that the Arg-Arg-Lys (RRK) stretch of the C-terminal ELYS region plays an essential role in the nucleosome binding.	Arginine	22-25	AT-hook containing transcription factor 1	Homo sapiens	66-70
31069272-4	2019	Here we show that the Arg-Arg-Lys (RRK) stretch of the C-terminal ELYS region plays an essential role in the nucleosome binding.	Arginine	26-29	AT-hook containing transcription factor 1	Homo sapiens	66-70
30392062-1	2019	The protein arginine methyltransferase 5 (PRMT5) and its catalytic partner methylosome protein MEP50 (WDR77) catalyse the mono- and symmetric di-methylation of selective arginines in various histones and non-histone target proteins.	Arginine	170-179	WD repeat domain 77	Homo sapiens	95-100
30392062-1	2019	The protein arginine methyltransferase 5 (PRMT5) and its catalytic partner methylosome protein MEP50 (WDR77) catalyse the mono- and symmetric di-methylation of selective arginines in various histones and non-histone target proteins.	Arginine	170-179	WD repeat domain 77	Homo sapiens	102-107
30822809-11	2019	Three platforms showed lower sensitivity for MoAB directed against the glycine (Gly) 40-arginine (Arg) 43 epitope of domain I of beta2GPI.	Arginine	98-101	apolipoprotein H	Homo sapiens	129-137
30869672-7	2019	Moreover, IUGR suckling Hu lambs in the Arg or NCG group were also linked with higher citrate synthase, isocitrate dehydrogenase and alpha-oxoglutarate dehydrogenase complex activities in the duodenum, jejunum and ileum compared with those found for IUGR suckling Hu lambs (P &lt; 0.05), except for the activity of isocitrate dehydrogenase in the ileum.	Arginine	40-43	citrate synthase, mitochondrial	Ovis aries	86-102
31013889-4	2019	In this study, the (pI)DPhe position of the tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 (an MC3R agonist/MC4R antagonist ligand) was investigated with a library of 12 compounds.	Arginine	64-67	melanocortin 4 receptor	Mus musculus	102-106
30848915-1	2019	In microorganisms and plants, N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step in l-arginine synthesis, the phosphorylation of N-Acetyl-l-glutamate (NAG) to give N-acetyl-l-glutamate-5-phosphate.	Arginine	94-104	N-acetylglucosamine kinase	Homo sapiens	30-57
30848915-1	2019	In microorganisms and plants, N-acetyl-l-glutamate kinase (NAGK) catalyzes the second step in l-arginine synthesis, the phosphorylation of N-Acetyl-l-glutamate (NAG) to give N-acetyl-l-glutamate-5-phosphate.	Arginine	94-104	N-acetylglucosamine kinase	Homo sapiens	59-63
30738683-8	2019	In addition, the dry matter intake, apparent digestibility of N, and the concentration of milk protein N in the Nor-NOHA did not differ from the control; however, the infusion of nor-NOHA and Arg resulted in greater concentrations of high-density lipoprotein, IgA, IL-1beta, and tumor necrosis factor-alpha, and lower concentrations of cholesterol in serum compared with the control.	Arginine	192-195	tumor necrosis factor	Bos taurus	279-306
30837227-0	2019	The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently.	Arginine	34-37	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	38-42
30674553-8	2019	Furthermore, we show that the loss of the components of the Arg/N-end rule pathway substantially suppresses the growth defects of naa20Delta yeast cells lacking the catalytic subunit of NatB Nt acetylase at 37  C. Collectively, the results of our study reveal that NME is a key upstream step for the creation of the Arg/N-end rule substrates bearing tertiary destabilizing residues in vivo.	Arginine	60-63	peptide alpha-N-acetyltransferase complex B subunit NAT3	Saccharomyces cerevisiae S288C	130-135
30674553-8	2019	Furthermore, we show that the loss of the components of the Arg/N-end rule pathway substantially suppresses the growth defects of naa20Delta yeast cells lacking the catalytic subunit of NatB Nt acetylase at 37  C. Collectively, the results of our study reveal that NME is a key upstream step for the creation of the Arg/N-end rule substrates bearing tertiary destabilizing residues in vivo.	Arginine	316-319	peptide alpha-N-acetyltransferase complex B subunit NAT3	Saccharomyces cerevisiae S288C	130-135
30521896-3	2019	For interaction, the three oligopeptides from the HIV gp120 were peptide A 297TRPNNNTRKRIRIQRGPGRA316 with several lysine (K) and arginine (R) in the V3 loop region, peptide B 493PLGVAPTKAKRRVVQREKR511 with several K and R in the C-terminus region, and oligopeptide C 362KQSSGGDPEIVTHSFNCGG380 with few basic amino acids in the CD4 binding domain.	Arginine	130-138	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	54-59
30604225-0	2019	C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A.	Arginine	8-16	eukaryotic translation initiation factor 1A	Drosophila melanogaster	140-145
30639019-8	2019	Both Met and Arg had no effect on MTOR proteins, but the phosphorylated EIF4EBP1 decreased by AA, especially Arg.	Arginine	109-112	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	72-80
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	mechanistic target of rapamycin kinase	Mus musculus	128-132
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	sterol regulatory element binding transcription factor 1	Mus musculus	134-140
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	Janus kinase 2	Mus musculus	151-155
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	thymoma viral proto-oncogene 2	Mus musculus	177-181
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	insulin receptor substrate 1	Mus musculus	183-187
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	212-218
30696923-6	2019	Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1), which catabolize Trp and Arg, respectively, respond to inflammatory cues including interferons and transforming growth factor-beta (TGFbeta) cytokines.	Arginine	82-85	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
30696923-6	2019	Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1), which catabolize Trp and Arg, respectively, respond to inflammatory cues including interferons and transforming growth factor-beta (TGFbeta) cytokines.	Arginine	82-85	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
30590246-0	2019	l-arginine protects against T-2 toxin-induced male reproductive impairments in mice.	Arginine	0-10	brachyury 2	Mus musculus	28-31
30590246-1	2019	l-arginine is beneficial for reproductive health; however, whether l-arginine may confer protection against T-2 toxin-induced reproductive impairment is not known.	Arginine	67-77	brachyury 2	Mus musculus	108-111
30590246-4	2019	The results showed that l-arginine improved semen quality (e.g., live spermatozoa, abnormal spermatozoa, and acrosomal integrity of spermatozoa), testicular and cauda epididymal sperm counts, efficiency of sperm production and serum testosterone concentration in mice treated with T-2 toxin.	Arginine	24-34	brachyury 2	Mus musculus	281-284
30651352-0	2019	Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.	Arginine	0-3	NPR2 like, GATOR1 complex subunit	Homo sapiens	10-15
30651352-7	2019	Here, using site-directed mutagenesis, GTP hydrolysis assays, coimmunoprecipitation experiments, and structural analysis, we probed the GAP mode and found that a critical residue on Nprl2, Arg-78, is the arginine finger that carries out GATOR1"s GAP function.	Arginine	204-212	NPR2 like, GATOR1 complex subunit	Homo sapiens	182-187
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	heme oxygenase 1	Homo sapiens	140-144
30702579-14	2019	INTERVENTIONS AND OUTCOMES: With regard to the sequencing of this patient, a heterozygous point mutation of G403C in PARK2 was detected, which was inherited from his unaffected mother, leading to an amino acid alternation of glycine to arginine.	Arginine	236-244	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	117-122
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	123-133	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-32
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	123-133	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	34-40
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	135-140	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-32
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	135-140	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	34-40
31016108-3	2019	Herein, mesoionic dye A1094 encapsulated in Arg-Gly-Asp-modified hepatitis B virus core protein (RGD-HBc) is designed and synthesized for effective NIR II PAI of brain gliomas.	Arginine	44-47	keratin 88, pseudogene	Homo sapiens	101-104
30697165-6	2018	Allosteric modulators of calcium-sensing receptor (CaSR) and G-protein coupled receptor class C group 6 member A (GPRC6A) had inhibitory effects on cell death induced by L-arginine but not L-ornithine or L-histidine.	Arginine	170-180	G protein-coupled receptor, family C, group 6, member A	Mus musculus	61-112
30697165-6	2018	Allosteric modulators of calcium-sensing receptor (CaSR) and G-protein coupled receptor class C group 6 member A (GPRC6A) had inhibitory effects on cell death induced by L-arginine but not L-ornithine or L-histidine.	Arginine	170-180	G protein-coupled receptor, family C, group 6, member A	Mus musculus	114-120
30391748-6	2019	MGO (100 microM) inhibited IFN-gamma and LPS-stimulated iNOS expression through inhibiting Akt phosphorylation and inhibition of iNOS expression was prevented by L-arginine (100 microM) co-treatment.	Arginine	162-172	interferon gamma	Rattus norvegicus	27-36
30430732-2	2019	This study focuses on the arginine to glutamine (R58Q) substitution in the human ventricular RLC (MYL2 gene), linked to malignant hypertrophic cardiomyopathy in humans and causing severe functional abnormalities in transgenic (Tg) R58Q mice, including inhibition of cardiac RLC phosphorylation.	Arginine	26-34	myosin light chain 2	Homo sapiens	98-102
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	4-7	Spi-1 proto-oncogene	Homo sapiens	225-229
30355733-4	2018	The Arg-232 pocket was computationally screened for small-molecule binding aimed at IL1B transcription inhibition, yielding l-arginine, a known anti-inflammatory amino acid, revealing a potential for disrupting the C/EBPbeta-Spi1 interaction.	Arginine	124-134	Spi-1 proto-oncogene	Homo sapiens	225-229
30355733-5	2018	As evaluated by ChIP, cultured lipopolysaccharide (LPS)-activated THP-1 cells incubated with l-arginine had significantly decreased IL1B transcription and reduced C/EBPbeta"s association with Spi1 on the IL1B promoter.	Arginine	93-103	Spi-1 proto-oncogene	Homo sapiens	192-196
30352217-5	2018	We observed that cdk8 and cycC mutants are sensitive to the levels of dietary proteins and seven amino acids (arginine, glutamine, isoleucine, leucine, methionine, threonine, and valine).	Arginine	110-118	Cyclin-dependent kinase 8	Drosophila melanogaster	17-21
30420520-10	2018	Together, PRMT6-induced arginine methylation of SIRT7 coordinates glucose availability with mitochondria biogenesis to maintain energy homeostasis.	Arginine	24-32	protein arginine N-methyltransferase 6	Mus musculus	10-15
30206180-7	2018	In vitro, we showed that transcription factor Pho4p can be methylated at Arg-241, which could explain phosphate dysregulation in hmt1Delta if interplay exists with phosphorylation at Ser-242 or Ser-243, or if Arg-241 methylation affects the capacity of Pho4p to homodimerize or interact with Pho2p.	Arginine	73-76	Pho2p	Saccharomyces cerevisiae S288C	292-297
30451821-5	2018	RORgammat is SUMO3-modified by E3 ligase PIAS4 at lysine 31 (K31), and the mutation of K31 to arginine in mice prevents RORgammat sumoylation, leading to impaired TH17 differentiation, resistance to TH17-mediated EAE, accumulation of thymic ISPs, and a lack of Peyer"s patches.	Arginine	94-102	protein inhibitor of activated STAT 4	Mus musculus	41-46
30483512-5	2018	Studies on these organisms yielded a first structure of a PII complex with an enzyme, (N-acetyl-Lglutamate kinase, NAGK), deciphering how PII can cause enzyme activation, and how it promotes nitrogen stockpiling as arginine in cyanobacteria and plants.	Arginine	215-223	N-acetylglucosamine kinase	Homo sapiens	115-119
30025375-2	2018	In this paper we study the interaction of Bz-Arg-NHC12 with sheep and human red blood cells (SRBC and HRBC respectively) due to their different membrane physicochemical/biophysical properties.	Arginine	45-48	caveolae associated protein 3	Homo sapiens	93-97
30347783-0	2018	Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line.	Arginine	11-19	bone morphogenetic protein receptor type 2	Homo sapiens	63-67
30332648-5	2018	Integrated transcriptome and protein-protein interaction studies revealed an enrichment of genes implicated in RAS signaling and showed that PRMT6 interacted with CRAF on arginine 100, which decreased its RAS binding potential and altered its downstream MEK/ERK signaling.	Arginine	171-179	protein arginine N-methyltransferase 6	Mus musculus	141-146
30332648-6	2018	Our work describes a critical repressive function for PRMT6 in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100.	Arginine	163-171	protein arginine N-methyltransferase 6	Mus musculus	54-59
29718707-8	2018	Although total AQP2 and phosphorylated AQP2-S256 levels (mediated by PKA) in kidneys under water deprivation conditions were significantly higher in Arg-II-/- mice compared with WT animals, there is no difference in the ratio of AQP2-S256:AQP2.	Arginine	149-152	aquaporin 2	Mus musculus	39-43
30099270-9	2018	Se/Arg preconditioning expanded levels of tubulin and NeuN.	Arginine	3-6	RNA binding fox-1 homolog 3	Rattus norvegicus	54-58
30323285-6	2018	Inhibition of PGK1 results in accumulation of the reactive metabolite methylglyoxal, which selectively modifies KEAP1 to form a methylimidazole crosslink between proximal cysteine and arginine residues (MICA).	Arginine	184-192	phosphoglycerate kinase 1	Homo sapiens	14-18
30288668-2	2018	Arginase-I (ARGI) accumulation at sites of amyloid-beta (Abeta) deposition is associated with L-arginine deprivation and neurodegeneration.	Arginine	94-104	amyloid beta (A4) precursor protein	Mus musculus	57-62
30288668-7	2018	The findings point to an association of local Abeta-driven and immune-mediated responses with altered L-arginine metabolism, and they suggest that arginase and S6K1 inhibition by L-norvaline may delay the progression of AD.	Arginine	102-112	amyloid beta (A4) precursor protein	Mus musculus	46-51
30456381-5	2018	We identified the major CARM1-mediated MED12 methylation site as arginine 1899 (R1899), which interacts with the Tudor domain-containing effector molecule, TDRD3.	Arginine	65-73	mediator complex subunit 12	Homo sapiens	39-44
30232226-7	2018	A randomized controlled trial demonstrated that arginine administration was correlated with enhanced Plt-NO concentration, suppressed platelet activation, and elevated CD3-zeta chain expression and eventually associated with an accelerated virus clearance and thrombocytopenia recovery.	Arginine	48-56	CD247 molecule	Homo sapiens	168-182
29802959-8	2018	Site-specific, covalent modifications of apoA-I (lysines or arginines) led to altered protein structure, reduced lipid binding capability and a reduced ability to catalyze cholesterol efflux from macrophages, partly in a modification-specific manner.	Arginine	60-69	apolipoprotein A1	Rattus norvegicus	41-47
29453600-5	2018	In humans, arginine is a semi-essential amino acid and its synthesis enzyme argininosuccinate synthetase (ASS1) represents the rate-limiting step in arginine biosynthesis.	Arginine	11-19	argininosuccinate synthase 1	Homo sapiens	106-110
29574762-4	2018	DC activation by lipopolysaccharide (LPS), CD40L or TLR8 agonist significantly enhanced Arg II expression without affecting Arg I expression.	Arginine	88-91	CD40 ligand	Mus musculus	43-48
30122195-4	2018	l-Arg deprivation markedly increased the mRNA expression of heat shock protein 70 and heme-oxygenase-1 under HS conditions.	Arginine	0-5	heme oxygenase 1	Homo sapiens	86-102
30054435-3	2018	The protein arginine methyltransferase 5 (PRMT5) and its partner methylosome protein 50 (MEP50) together catalyze the mono- and symmetric dimethylation of arginine residues in many histone and non-histone protein substrates.	Arginine	12-20	WD repeat domain 77	Homo sapiens	65-87
30054435-3	2018	The protein arginine methyltransferase 5 (PRMT5) and its partner methylosome protein 50 (MEP50) together catalyze the mono- and symmetric dimethylation of arginine residues in many histone and non-histone protein substrates.	Arginine	12-20	WD repeat domain 77	Homo sapiens	89-94
30139231-6	2018	A missensemutation (c.47C&gt;A/p.Pro146Glu) and in-frame deletion of a CAG sequence leading to loss of Arginine at codon 85(c.252_254delCAG/p.Arg85-) were identified in a 70 year old patient with a Gleason Score and PSA level of 2 and2.4ng/dL, respectively.	Arginine	103-111	aminopeptidase puromycin sensitive	Homo sapiens	216-219
30125331-0	2018	A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1alpha protein.	Arginine	65-73	hypoxia inducible factor 1, alpha subunit	Mus musculus	91-101
30125331-3	2018	We determined that NleB-mediated GlcNAcylation at a conserved arginine 18 (Arg18) at the N-terminus of HIF-1alpha enhanced HIF-1alpha transcriptional activity, thereby inducing HIF-1alpha downstream gene expression to alter host glucose metabolism.	Arginine	62-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	103-113
30125331-3	2018	We determined that NleB-mediated GlcNAcylation at a conserved arginine 18 (Arg18) at the N-terminus of HIF-1alpha enhanced HIF-1alpha transcriptional activity, thereby inducing HIF-1alpha downstream gene expression to alter host glucose metabolism.	Arginine	62-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	123-133
30125331-3	2018	We determined that NleB-mediated GlcNAcylation at a conserved arginine 18 (Arg18) at the N-terminus of HIF-1alpha enhanced HIF-1alpha transcriptional activity, thereby inducing HIF-1alpha downstream gene expression to alter host glucose metabolism.	Arginine	62-70	hypoxia inducible factor 1, alpha subunit	Mus musculus	123-133
30110646-6	2018	Validation of hemopexin (HPX) as a ARTC1-target protein confirmed the functional importance of ARTC1-mediated extracellular arginine ADP-ribosylation at the systems level.	Arginine	124-132	hemopexin	Mus musculus	14-23
29950483-0	2018	Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling.	Arginine	8-16	bone morphogenetic protein 1	Homo sapiens	105-108
29950483-6	2018	Inhibition of BMP signaling by Noggin rescues the lung branching defects of Prmt5 mutant in vitro Taken together, our results identify a novel mechanism through which Prmt5-mediated histone arginine methylation represses canonical BMP signaling to regulate lung branching morphogenesis.	Arginine	190-198	bone morphogenetic protein 1	Homo sapiens	14-17
29950483-6	2018	Inhibition of BMP signaling by Noggin rescues the lung branching defects of Prmt5 mutant in vitro Taken together, our results identify a novel mechanism through which Prmt5-mediated histone arginine methylation represses canonical BMP signaling to regulate lung branching morphogenesis.	Arginine	190-198	bone morphogenetic protein 1	Homo sapiens	231-234
29722926-4	2018	Akin to cytochrome-b5 (cyt-b5 ), Arg 125 on the C-helix of CYP450s is found to be important for effective electron transfer, thus supporting the competitive behavior of redox partners for CYP450s.	Arginine	33-36	cytochrome b5 type A	Homo sapiens	8-21
29722926-4	2018	Akin to cytochrome-b5 (cyt-b5 ), Arg 125 on the C-helix of CYP450s is found to be important for effective electron transfer, thus supporting the competitive behavior of redox partners for CYP450s.	Arginine	33-36	cytochrome b5 type A	Homo sapiens	23-29
29967538-4	2018	X-ray crystal structures of TIRR and a designer protein bound to 53BP1 now reveal a unique regulatory mechanism in which an intricate binding area centered on an essential TIRR arginine residue blocks the methylated-chromatin-binding surface of 53BP1.	Arginine	177-185	tumor protein p53 binding protein 1	Homo sapiens	65-70
29967538-4	2018	X-ray crystal structures of TIRR and a designer protein bound to 53BP1 now reveal a unique regulatory mechanism in which an intricate binding area centered on an essential TIRR arginine residue blocks the methylated-chromatin-binding surface of 53BP1.	Arginine	177-185	tumor protein p53 binding protein 1	Homo sapiens	245-250
29741277-4	2018	Extensive antimicrobial susceptibility assessment against a panel of clinically relevant Staphylococcus aureus and Propionibacterium acnes strains led to the identification of the new lead compound, [Arg(Me)10 ,Nle11 ]teixobactin, with an excellent bactericidal activity (minimum inhibitory concentration (MIC)=2-4 mug mL-1 ).	Arginine	200-203	L1 cell adhesion molecule	Mus musculus	319-323
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Arginine	119-122	transformed mouse 3T3 cell double minute 2	Mus musculus	69-92
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Arginine	119-122	transformed mouse 3T3 cell double minute 2	Mus musculus	94-98
29775303-3	2018	Analyzing the results of a previous virtual screening against murine double minute 2 protein (MDM2), we envisaged that Arg-Gly-Asp (RGD)-mimetic molecules could be inhibitors of MDM2/4.	Arginine	119-122	transformed mouse 3T3 cell double minute 2	Mus musculus	178-182
29804448-6	2018	Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P &lt; 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P &lt; 0.05) and proline stimulated lamin A/C expression ( P &lt; 0.05).	Arginine	38-46	progesterone receptor membrane component 1	Homo sapiens	81-87
29804448-6	2018	Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P &lt; 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P &lt; 0.05) and proline stimulated lamin A/C expression ( P &lt; 0.05).	Arginine	38-46	vimentin	Homo sapiens	207-215
29804448-6	2018	Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P &lt; 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P &lt; 0.05) and proline stimulated lamin A/C expression ( P &lt; 0.05).	Arginine	38-46	lamin A/C	Homo sapiens	220-229
29804448-6	2018	Among the NCG-associated amino acids, arginine and glutamine, markedly increased PGRMC1 and eNOS expression in porcine trophectoderm cells ( P &lt; 0.05), whereas glutamate could stimulate the expression of vimentin and lamin A/C in porcine trophectoderm (pTr) cells ( P &lt; 0.05) and proline stimulated lamin A/C expression ( P &lt; 0.05).	Arginine	38-46	lamin A/C	Homo sapiens	305-314
29603287-5	2018	Lysine 1667 is essential for interaction with importin and its substitution to arginine reduced nuclear localisation of 53BP1.	Arginine	79-87	tumor protein p53 binding protein 1	Homo sapiens	120-125
29550892-7	2018	The presence of a single nucleotide polymorphism causing an amino acid change in a near actin-interacting domain of Arg, in addition to altered lymphocyte activation in the congenic mice upon immunization with myelin antigen, makes Abl2/Arg a candidate gene for EAE.	Arginine	116-119	N-acetylglutamate synthase	Mus musculus	237-242
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Arginine	92-95	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	29-36
29849110-3	2018	In this research we report a FRalpha binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRalpha expressing cells by cell ELISA and flow cytometry.	Arginine	92-95	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	177-184
29679901-0	2018	Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation.	Arginine	15-18	melanocortin 1 receptor	Homo sapiens	112-117
29679901-0	2018	Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH2, leads to hMC1R selectivity and pigmentation.	Arginine	90-93	melanocortin 1 receptor	Homo sapiens	112-117
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	8-11	NLR family, apoptosis inhibitory protein 2	Mus musculus	76-81
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	21-24	NLR family, apoptosis inhibitory protein 2	Mus musculus	76-81
29501774-4	2018	RESULTS: We found that stimulation of human lung adenocarcinoma cells with LPS triggered the monomethylation of arginine 50 (R50me) within Eno-1.	Arginine	112-120	enolase 1	Homo sapiens	139-144
29401583-1	2018	Argininosuccinate synthetase 1 (ASS1) is a rate-limited enzyme in arginine biosynthesis.	Arginine	66-74	argininosuccinate synthase 1	Homo sapiens	0-30
29401583-1	2018	Argininosuccinate synthetase 1 (ASS1) is a rate-limited enzyme in arginine biosynthesis.	Arginine	66-74	argininosuccinate synthase 1	Homo sapiens	32-36
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	fibronectin 1	Rattus norvegicus	62-73
29771430-0	2018	SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway.	Arginine	56-57	signal transducer and activator of transcription 3	Rattus norvegicus	62-67
2480354-10	1989	A synthetic Arg-Gly-Asp-Ser tetrapeptide (RGDS), specific for fibronectin and vitronectin adhesion receptors, inhibited TRH-, EGF-, and TPA-induced GH4 cell stretching and attachment to fibronectin- and vitronectin-coated dishes.	Arginine	12-15	fibronectin 1	Rattus norvegicus	186-197
2553732-2	1989	The amino-terminal sequence of the first 35 amino acid residues showed a replacement of Ser-29 of IGF-II with the tetrapeptide Arg-Leu-Pro-Gly of IGF-II variant.	Arginine	127-130	insulin like growth factor 2	Homo sapiens	98-104
29605436-5	2018	In BRD2-4, this residue is glutamine in BD1 and lysine in BD2; in BRDT, this residue is arginine in BD1 and asparagine in BD2.	Arginine	88-96	bromodomain testis associated	Homo sapiens	66-70
30023888-5	2018	Moreover, arginine-modified films exhibited a nearly equivalent cell viability compared to the films modified with the natural extracellular matrix component fibronectin.	Arginine	10-18	fibronectin 1	Mus musculus	158-169
2553732-2	1989	The amino-terminal sequence of the first 35 amino acid residues showed a replacement of Ser-29 of IGF-II with the tetrapeptide Arg-Leu-Pro-Gly of IGF-II variant.	Arginine	127-130	insulin like growth factor 2	Homo sapiens	146-152
2641847-4	1989	BK and its products cleft by carboxypeptidase B, des-Arg9-BK and arginine (Arg), activated the degradation of BANA.	Arginine	65-73	carboxypeptidase B1	Rattus norvegicus	29-47
29854093-0	2018	L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells.	Arginine	0-10	mechanistic target of rapamycin kinase	Mus musculus	57-61
29854093-4	2018	L-Arg supplementation increased the activity of inducible nitric oxide synthase (iNOS), the rate of protein synthesis, and the phosphorylation of mTOR (Thr 2446) and p70S6K (Thr 389).	Arginine	0-5	mechanistic target of rapamycin kinase	Mus musculus	146-150
2641847-4	1989	BK and its products cleft by carboxypeptidase B, des-Arg9-BK and arginine (Arg), activated the degradation of BANA.	Arginine	53-56	carboxypeptidase B1	Rattus norvegicus	29-47
29607917-5	2018	Gene analysis revealed an arginine-to-proline missense mutation in the NOTCH3 gene at codon 75.	Arginine	26-34	notch receptor 3	Homo sapiens	71-77
2641847-9	1989	It is suggested that BK is cleft by carboxypeptidase B in pulp cell to des-Arg9-BK and Arg, which activate the lysosomal or soluble EK processing enzymes, and then the produced EK inhibits the production of BK from plasma kininogens in the pulp.	Arginine	75-78	carboxypeptidase B1	Rattus norvegicus	36-54
2641847-9	1989	It is suggested that BK is cleft by carboxypeptidase B in pulp cell to des-Arg9-BK and Arg, which activate the lysosomal or soluble EK processing enzymes, and then the produced EK inhibits the production of BK from plasma kininogens in the pulp.	Arginine	75-78	proenkephalin	Rattus norvegicus	132-134
2641847-9	1989	It is suggested that BK is cleft by carboxypeptidase B in pulp cell to des-Arg9-BK and Arg, which activate the lysosomal or soluble EK processing enzymes, and then the produced EK inhibits the production of BK from plasma kininogens in the pulp.	Arginine	75-78	proenkephalin	Rattus norvegicus	177-179
2808368-1	1989	Peptidylarginine deiminase (proteinarginine iminohydrolase, EC 3.5.3.15) converted some arginine residues to citrulline residues in soluble vimentin, in a micromolar Ca2+-dependent manner and resulted in the loss of polymerization competence of the intermediate filament protein.	Arginine	8-16	vimentin	Homo sapiens	140-148
29641989-0	2018	Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.	Arginine	0-8	Meis homeobox 2	Homo sapiens	31-36
2668284-6	1989	However, the replacement of the activation peptide with an 8-residue sequence (Pro-Arg-Pro-Ser-Arg-Lys-Arg-Arg) involved in the proteolytic processing of the human insulin receptor precursor resulted in the direct expression of fully activated protein C.	Arginine	83-86	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	244-253
29641989-3	2018	Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1.	Arginine	165-173	Meis homeobox 2	Homo sapiens	24-29
29641989-3	2018	Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1.	Arginine	165-173	Meis homeobox 2	Homo sapiens	144-149
29641989-3	2018	Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1.	Arginine	165-173	exportin 1	Homo sapiens	261-265
29641989-3	2018	Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1.	Arginine	165-173	PBX homeobox 1	Homo sapiens	300-304
2668284-6	1989	However, the replacement of the activation peptide with an 8-residue sequence (Pro-Arg-Pro-Ser-Arg-Lys-Arg-Arg) involved in the proteolytic processing of the human insulin receptor precursor resulted in the direct expression of fully activated protein C.	Arginine	95-98	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	244-253
2668284-6	1989	However, the replacement of the activation peptide with an 8-residue sequence (Pro-Arg-Pro-Ser-Arg-Lys-Arg-Arg) involved in the proteolytic processing of the human insulin receptor precursor resulted in the direct expression of fully activated protein C.	Arginine	95-98	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	244-253
2547341-1	1989	Argininosuccinate synthetase and argininosuccinate lyase catalyze the synthesis of arginine from citrulline in kidney and also serve as components of the urea cycle in liver of ureotelic animals.	Arginine	83-91	argininosuccinate lyase	Rattus norvegicus	33-56
29471495-0	2018	Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.	Arginine	0-8	DNA topoisomerase III beta	Homo sapiens	58-63
29471495-3	2018	Here, we have identified arginine methylation as an important post-translational modification (PTM) for TOP3B activity.	Arginine	25-33	DNA topoisomerase III beta	Homo sapiens	104-109
29471495-4	2018	Protein arginine methyltransferase (PRMT) 1, PRMT3 and PRMT6 all methylate TOP3B in vitro at its C-terminal arginine (R) and glycine (G)-rich motif.	Arginine	8-16	DNA topoisomerase III beta	Homo sapiens	75-80
2791302-0	1989	Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts.	Arginine	118-126	argininosuccinate synthase 1	Homo sapiens	34-60
29670643-11	2018	The Arg allele carriers of ADRB3 gene Trp64Arg polymorphism may be at an increased risk for developing EH.	Arginine	4-7	adrenoceptor beta 3	Homo sapiens	27-32
2489081-5	1989	However in the case of L-arabinose, Arg 151 forms hydrogen bonds with the hydroxyl group at the C-4 atom and the ring oxygen, whereas in case of D-galactose it forms bonds with the hydroxyl groups at the C-4 and C-6 atoms of the pyranose ring.	Arginine	36-39	complement C4A (Rodgers blood group)	Homo sapiens	96-99
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Arginine	276-279	PTK2 protein tyrosine kinase 2	Mus musculus	146-176
29351412-4	2018	In this report, we present experimental evidence showing that ECM stimulates the synthesis of CTGF in response to lysophosphatidic acid (LPA).The integrin/focal adhesion kinase (FAK) signaling pathway mediates this effect, since CTGF expression is abolished by the use of the Arg-Gly-Asp-Ser peptide and also by an inhibitor of FAK autophosphorylation at tyrosine 397.	Arginine	276-279	PTK2 protein tyrosine kinase 2	Mus musculus	178-181
2489081-5	1989	However in the case of L-arabinose, Arg 151 forms hydrogen bonds with the hydroxyl group at the C-4 atom and the ring oxygen, whereas in case of D-galactose it forms bonds with the hydroxyl groups at the C-4 and C-6 atoms of the pyranose ring.	Arginine	36-39	complement C4A (Rodgers blood group)	Homo sapiens	204-207
2489085-1	1989	Anti-cell adhesive activity was examined by the synthetic polypeptide, containing repetitive Arg-Gly-Asp sequence of cell attachment site from fibronectin, poly (Arg-Gly-Asp).	Arginine	93-96	fibronectin 1	Mus musculus	143-154
2527365-4	1989	The mosxe gene is transforming when introduced into murine NIH 3T3 cells, and transformation is abrogated by a lysine-to-arginine mutation in the canonical ATP-binding site.	Arginine	121-129	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	4-9
29590114-6	2018	The c.2510G&gt;A transition variant is predicted to substitute a highly invariant arginine residue with histidine (p.Arg837His) in the phosphatase domain of PPIP5K2.	Arginine	82-90	diphosphoinositol pentakisphosphate kinase 2	Mus musculus	157-164
2736523-1	1989	We investigated that the antimetastatic and antiadhesive activities of peptides based on Arg-Gly-Asp adhesive signal in fibronectin could be augmented by their polymerization.	Arginine	89-92	fibronectin 1	Mus musculus	120-131
29581108-10	2018	We identified arginine residues at positions 38, 42, and 68 in the endoplasmatic reticulum luminal loop of VKORC1L1 responsible for charge-stabilized warfarin binding, resulting in a binding pocket that is diametrically opposite to that of VKORC1.	Arginine	14-22	vitamin K epoxide reductase complex subunit 1	Homo sapiens	107-113
29616026-4	2018	When SLC7A7/y+LAT1 was silenced in human THP-1 macrophages and A549 airway epithelial cells by means of short interference RNA (siRNA), a significant induction of the expression and release of the inflammatory mediators IL1beta and TNFalpha was observed, no matter the intracellular arginine availability.	Arginine	283-291	solute carrier family 7 member 7	Homo sapiens	5-11
29616026-4	2018	When SLC7A7/y+LAT1 was silenced in human THP-1 macrophages and A549 airway epithelial cells by means of short interference RNA (siRNA), a significant induction of the expression and release of the inflammatory mediators IL1beta and TNFalpha was observed, no matter the intracellular arginine availability.	Arginine	283-291	solute carrier family 7 member 5	Homo sapiens	14-18
2502202-7	1989	A model of the antibody combining site suggests that arginine 24 and arginine 30 in the light chain (CDR1) interact with a surface defined by phosphate or sulfate groups of the antigen.	Arginine	69-77	cerebellar degeneration related protein 1	Homo sapiens	101-105
2500154-7	1989	Thus, an acrosin assay using Tos-Gly-Pro-Arg p-nitroanilide as a substrate is more than 20-times as sensitive as existing assays with blocked arginine derivatives.	Arginine	142-150	acrosin	Homo sapiens	9-16
29616026-9	2018	In conclusion, our results point to a novel thus far unknown function of SLC7A7/y+LAT1, that, under physiological conditions, besides transporting arginine, may act as a brake to restrain inflammation.	Arginine	147-155	solute carrier family 7 member 7	Homo sapiens	73-79
29616026-9	2018	In conclusion, our results point to a novel thus far unknown function of SLC7A7/y+LAT1, that, under physiological conditions, besides transporting arginine, may act as a brake to restrain inflammation.	Arginine	147-155	solute carrier family 7 member 7	Homo sapiens	80-86
2525104-0	1989	A substrate of the cell-attachment sequence of fibronectin (Arg-Gly-Asp-Ser) is sufficient to promote transition of arterial smooth muscle cells from a contractile to a synthetic phenotype.	Arginine	60-63	fibronectin 1	Rattus norvegicus	47-58
29212043-6	2018	Experiments with mutant proteins demonstrated that the conserved arginines in the PN-binding pocket are involved in the inhibition of UCP1 and UCP3 to different extents.	Arginine	65-74	uncoupling protein 1	Homo sapiens	134-138
2525104-3	1989	Here, the ability of the cell-attachment sequence of fibronectin, Arg-Gly-Asp-Ser (RGDS), to promote this process was studied.	Arginine	66-69	fibronectin 1	Rattus norvegicus	53-64
2777004-4	1989	It turned out that TP1 is a small, but very basic protein with 54 amino acids (21% arginine, 19% lysine) and is highly conserved during mammalian evolution at the nucleotide as well as at the amino-acid level.	Arginine	83-91	transition protein 1	Homo sapiens	19-22
29023917-3	2018	Arginine methylation is controlled by the reciprocal activity of protein arginine methyltransferases, primarily protein arginine methyl transferase 1 (PRMT1), and a demethylase Jumonji C domain-containing protein 6 (JMJD6).	Arginine	0-8	protein arginine N-methyltransferase 1	Mus musculus	151-156
29023917-3	2018	Arginine methylation is controlled by the reciprocal activity of protein arginine methyltransferases, primarily protein arginine methyl transferase 1 (PRMT1), and a demethylase Jumonji C domain-containing protein 6 (JMJD6).	Arginine	0-8	jumonji domain containing 6	Mus musculus	177-214
29023917-3	2018	Arginine methylation is controlled by the reciprocal activity of protein arginine methyltransferases, primarily protein arginine methyl transferase 1 (PRMT1), and a demethylase Jumonji C domain-containing protein 6 (JMJD6).	Arginine	0-8	jumonji domain containing 6	Mus musculus	216-221
29023917-8	2018	We found that PRMT1 regulates Hnf4alpha expression directly through arginine methylation at the (Hnf4alpha) promoter.	Arginine	68-76	protein arginine N-methyltransferase 1	Mus musculus	14-19
2506109-3	1989	There was 1 bp change which would result in the substitution of Ser (TEM-7) for Arg (TEM-2) in amino acid (aa) position 162 (i.e., aa position 139 of the mature enzyme).	Arginine	80-83	plexin domain containing 1	Homo sapiens	69-74
28513838-2	2018	NPNT protein belongs to the epidermal growth factor (EGF)-like superfamily and exhibits several common structural determinants; including EGF-like repeat domains, MAM domain (Meprin, A5 Protein, and Receptor Protein-Tyrosine Phosphatase micro), RGD motif (Arg-Gly-Asp) and a coiled-coil domain.	Arginine	256-259	nephronectin	Homo sapiens	0-4
2567165-4	1989	The tyrosinase gene in the Himalayan mouse contains an A----G change at nucleotide 1259 that alters a histidine residue to an arginine residue at amino acid 420.	Arginine	126-134	tyrosinase	Mus musculus	4-14
29092819-1	2018	Protein arginine methyltransferase 1 (PRMT1), PRMT4, and PRMT5 catalyze the methylation of arginine residues on target proteins.	Arginine	8-16	protein arginine N-methyltransferase 1	Mus musculus	38-43
29154924-6	2018	Replacement of G204 with arginine appears to cause a more complex defect with impact both on iron export function and hepcidin sensitivity.	Arginine	25-33	hepcidin antimicrobial peptide	Homo sapiens	118-126
2566116-4	1989	This mutation converts the 340th amino acid of NADH dehydrogenase subunit 4 from an arginine to a histidine and eliminates an SfaNI endonuclease restriction site.	Arginine	84-92	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	47-75
29052764-6	2018	Sequence analysis indicated that the coding region (CDS) of GhChlI is 1269 bp in length, with three predicted exons and one non-synonymous nucleotide mutation (G1082A) in the third exon of Gh_D10G0283, with an amino acid (AA) substitution of arginine (R) to lysine (K).	Arginine	242-250	magnesium-chelatase subunit ChlI, chloroplastic	Gossypium hirsutum	60-66
2499322-6	1989	These results suggest that the 49-kDa intermediate is produced from 53-kDa proacrosin during proacrosin activation by the cleavage of the peptide bond between Arg-23 and Val-24, which results in the formation of the light and heavy chains.	Arginine	159-162	acrosin	Homo sapiens	75-85
29670690-1	2018	Somatic point mutations at a key arginine residue (R132) within the active site of the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer a novel gain of function in cancer cells, resulting in the production of d-2-hydroxyglutarate (2-HG), an oncometabolite.	Arginine	33-41	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	132-136
29227283-4	2018	Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI.	Arginine	107-115	SRY-box transcription factor 10	Homo sapiens	71-76
2499322-6	1989	These results suggest that the 49-kDa intermediate is produced from 53-kDa proacrosin during proacrosin activation by the cleavage of the peptide bond between Arg-23 and Val-24, which results in the formation of the light and heavy chains.	Arginine	159-162	acrosin	Homo sapiens	93-103
29227283-4	2018	Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI.	Arginine	107-115	melanocyte inducing transcription factor	Homo sapiens	81-85
2542247-17	1989	Considered together, our data suggest that Arg-89 is located at or near the active site of bisphosphoglycerate mutase and that this residue is probably involved in the binding of monophosphoglycerates.	Arginine	43-46	bisphosphoglycerate mutase	Homo sapiens	91-117
29150243-5	2018	Both NCG and ARG inhibited (P&lt;0.05) IGF1- and FSH-induced GC estradiol production but only NCG inhibited (P&lt;0.05) progesterone production.	Arginine	13-16	insulin like growth factor 1	Bos taurus	39-43
29150243-6	2018	In contrast, NCG and ARG increased (P&lt;0.05) GC numbers induced by IGF1 and FSH.	Arginine	21-24	insulin like growth factor 1	Bos taurus	69-73
2708351-11	1989	As a result, it was concluded that the C terminus of the 66,000-dalton, 64,000-dalton, and 61,000-dalton MLC kinase fragments are arginine 522, lysine 490 and arginine 494, and lysine 473, respectively.	Arginine	130-138	myosin light chain kinase	Homo sapiens	105-115
29150243-8	2018	We conclude that NCG and ARG may act directly on GC and therefore may regulate ovarian function by slowing follicular differentiation via inhibiting IGF1 action, and steroid synthesis while stimulating GC proliferation in cattle.	Arginine	25-28	insulin like growth factor 1	Bos taurus	149-153
2708351-11	1989	As a result, it was concluded that the C terminus of the 66,000-dalton, 64,000-dalton, and 61,000-dalton MLC kinase fragments are arginine 522, lysine 490 and arginine 494, and lysine 473, respectively.	Arginine	159-167	myosin light chain kinase	Homo sapiens	105-115
2545252-5	1989	The influence of Arg-38 on the oxidation-reduction equilibrium of yeast iso-1-cytochrome c has now been investigated by electrochemical, NMR, and theoretical analysis of six specifically mutated forms of this protein in which Arg has been replaced by Lys, His, Gln, Asn, Leu, or Ala.	Arginine	17-20	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	72-77
30466103-1	2018	Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	92-122
2469950-2	1989	The carboxyl-terminal domain of P19 (amino acids 150-183) is arginine-rich (47%) and faces the interior of the nucleocapsid for the binding with DNA.	Arginine	61-69	interleukin 23 subunit alpha	Homo sapiens	32-35
29303363-1	2018	In recent years, de novo missense structural mutations in the IDH1 gene of arginine at site 132 (R132) have become a standard for diagnostication and prognostication in glioma management.	Arginine	75-83	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	62-66
2469950-7	1989	A synthetic arginine-rich decapeptide, with a sequence of Arg-Arg-Arg-Gly-Arg-Ser-Pro-Arg-Arg-Arg, representing amino acids 150-159 of P19 and conserved in the majority of reported hepatitis B virus, absorbed the activity to bind with P19 in seven (44%) out of 16 sera containing anti-HBic.	Arginine	12-20	interleukin 23 subunit alpha	Homo sapiens	135-138
2469950-7	1989	A synthetic arginine-rich decapeptide, with a sequence of Arg-Arg-Arg-Gly-Arg-Ser-Pro-Arg-Arg-Arg, representing amino acids 150-159 of P19 and conserved in the majority of reported hepatitis B virus, absorbed the activity to bind with P19 in seven (44%) out of 16 sera containing anti-HBic.	Arginine	12-20	interleukin 23 subunit alpha	Homo sapiens	235-238
29226865-8	2018	Substituting K52 residue of SC35 by arginine impairs the role of SC35 in tau exon 10 inclusion.	Arginine	36-44	microtubule associated protein tau	Homo sapiens	73-76
2648407-7	1989	In response to an infusion of L-arginine, serum insulin increased from 566 to 1256 pg/ml in the in ovo embryos, whereas no change was evident in the ex ovo embryos (233 vs 257 pg/ml).	Arginine	30-40	insulin	Meleagris gallopavo	48-55
28832976-2	2017	Normal cells synthesize arginine with the enzyme argininosuccinate synthetase (ASS1); ADI-PEG 20 selectively targets malignant cells, which lack ASS1.	Arginine	24-32	argininosuccinate synthase 1	Homo sapiens	79-83
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Arginine	97-100	fibronectin 1	Mus musculus	23-34
2706569-5	1989	Antibodies against the fibronectin receptor of CHO fibroblasts and short peptides containing the Arg-Gly-Asp sequence greatly reduced PGC adhesion to fibronectin.	Arginine	97-100	fibronectin 1	Mus musculus	150-161
28646562-7	2017	We observed specific up-regulation of the arginine synthesis pathway associated with overexpression of argininosuccinate synthase (ASS1) and arginosuccinate lyase in UHCA.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	103-129
2536701-6	1989	Residues 49, 50, and 51 in IGF I are Phe-Arg-Ser and are strictly conserved in IGF II.	Arginine	41-44	insulin like growth factor 2	Homo sapiens	79-85
28646562-7	2017	We observed specific up-regulation of the arginine synthesis pathway associated with overexpression of argininosuccinate synthase (ASS1) and arginosuccinate lyase in UHCA.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	131-135
29094484-3	2017	It has been reported that naive melanoma cells undergo autophagy and re-express argininosuccinate synthetase 1 (ASS1) to enable them to synthesize arginine for survival when encountering arginine deprivation.	Arginine	147-155	argininosuccinate synthase 1	Homo sapiens	80-110
29094484-3	2017	It has been reported that naive melanoma cells undergo autophagy and re-express argininosuccinate synthetase 1 (ASS1) to enable them to synthesize arginine for survival when encountering arginine deprivation.	Arginine	147-155	argininosuccinate synthase 1	Homo sapiens	112-116
29094484-3	2017	It has been reported that naive melanoma cells undergo autophagy and re-express argininosuccinate synthetase 1 (ASS1) to enable them to synthesize arginine for survival when encountering arginine deprivation.	Arginine	187-195	argininosuccinate synthase 1	Homo sapiens	80-110
29094484-3	2017	It has been reported that naive melanoma cells undergo autophagy and re-express argininosuccinate synthetase 1 (ASS1) to enable them to synthesize arginine for survival when encountering arginine deprivation.	Arginine	187-195	argininosuccinate synthase 1	Homo sapiens	112-116
2536701-7	1989	Residues 55 and 56 of IGF I and the corresponding residues in IGF II are Arg-Arg and Ala-Leu, respectively.	Arginine	73-76	insulin like growth factor 2	Homo sapiens	62-68
2536701-7	1989	Residues 55 and 56 of IGF I and the corresponding residues in IGF II are Arg-Arg and Ala-Leu, respectively.	Arginine	77-80	insulin like growth factor 2	Homo sapiens	62-68
2912899-0	1989	Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.	Arginine	54-57	leishmanolysin like peptidase	Homo sapiens	118-122
28940424-12	2017	In addition, homology modelling and molecular dynamic simulation of N1366S and wild-type NaV1.4 channels indicated that the arginine-to-serine substitution disrupted the hydrogen bond formed between N1366 and R1454.	Arginine	124-132	sodium voltage-gated channel alpha subunit 4	Homo sapiens	89-95
2912899-0	1989	Antibodies raised against synthetic peptides from the Arg-Gly-Asp-containing region of the Leishmania surface protein gp63 cross-react with human C3 and interfere with gp63-mediated binding to macrophages.	Arginine	54-57	leishmanolysin like peptidase	Homo sapiens	168-172
2912899-2	1989	Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3.	Arginine	59-62	leishmanolysin like peptidase	Homo sapiens	108-112
29131831-8	2017	CPD cleaved C-terminal Lys or Arg from a subset of the peptides.	Arginine	30-33	carboxypeptidase D	Homo sapiens	0-3
2912899-2	1989	Antibody raised against a synthetic peptide containing the Arg-Gly-Asp region of the amino acid sequence of gp63 recognizes both gp63 and the alpha-chain of human C3.	Arginine	59-62	leishmanolysin like peptidase	Homo sapiens	129-133
2478827-2	1989	Nitric oxide (EDRF) is the most important relaxing factor that is released from L-arginine and evokes relaxation by increasing intracellular cyclic GMP in vascular smooth muscle.	Arginine	80-90	alpha hemoglobin stabilizing protein	Homo sapiens	14-18
2544772-8	1989	These data confirm and extend exploratory studies performed with a simpler vascular model which indicate that the precursor of endothelium derived relaxing factor (EDRF) is an arginine moiety.	Arginine	176-184	alpha hemoglobin stabilizing protein	Homo sapiens	127-162
28977470-3	2017	ZNF326 is symmetrically dimethylated at arginine 175 (R175) and this modification is lost in a PRMT5 and WDR77-dependent manner.	Arginine	40-48	WD repeat domain 77	Homo sapiens	105-110
2544772-8	1989	These data confirm and extend exploratory studies performed with a simpler vascular model which indicate that the precursor of endothelium derived relaxing factor (EDRF) is an arginine moiety.	Arginine	176-184	alpha hemoglobin stabilizing protein	Homo sapiens	164-168
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	GRDX	Homo sapiens	32-35
28418601-0	2017	Two arginine residues in the COOH-terminal of human beta-defensin-3 constitute an essential motif for antimicrobial activity and IL-6 production.	Arginine	4-12	defensin beta 103B	Homo sapiens	52-67
28418601-2	2017	HBD-3 contains a unique motif of two arginine residues (Arg or R) in the COOH-terminal region.	Arginine	37-45	defensin beta 103B	Homo sapiens	0-5
28418601-2	2017	HBD-3 contains a unique motif of two arginine residues (Arg or R) in the COOH-terminal region.	Arginine	56-59	defensin beta 103B	Homo sapiens	0-5
28418601-2	2017	HBD-3 contains a unique motif of two arginine residues (Arg or R) in the COOH-terminal region.	Arginine	63-64	defensin beta 103B	Homo sapiens	0-5
3058511-1	1988	A synthetic peptide Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala, the structure of which is based on that of a phosphorylated sequence in ribosomal protein S6, was employed as a probe for stimulated kinase activity in Xenopus laevis oocytes induced to mature with insulin or progesterone.	Arginine	20-23	insulin S homeolog	Xenopus laevis	251-258
28418601-3	2017	To understand the bioactive properties of the Arg residues of HBD-3, we examined antimicrobial activities against Staphylococcus aureus and Pseudomonas aeruginosa using synthetic HBD-2, HBD-3 and two variant peptides of HBD-3: the Arg-truncated variant designated desR HBD-3 and NRR HBD-3, in which both Arg residues were shifted to the N-terminal region.	Arginine	46-49	defensin beta 103B	Homo sapiens	62-67
28418601-9	2017	These Arg residues are essential for the antimicrobial and biological properties of HBD-3.	Arginine	6-9	defensin beta 103B	Homo sapiens	84-89
3058511-1	1988	A synthetic peptide Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala, the structure of which is based on that of a phosphorylated sequence in ribosomal protein S6, was employed as a probe for stimulated kinase activity in Xenopus laevis oocytes induced to mature with insulin or progesterone.	Arginine	24-27	insulin S homeolog	Xenopus laevis	251-258
3058511-1	1988	A synthetic peptide Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala, the structure of which is based on that of a phosphorylated sequence in ribosomal protein S6, was employed as a probe for stimulated kinase activity in Xenopus laevis oocytes induced to mature with insulin or progesterone.	Arginine	24-27	insulin S homeolog	Xenopus laevis	251-258
3066908-11	1988	MCM1 has striking homology to ARG80, a regulatory gene of the arginine metabolic pathway located about 700 base-pairs upstream from MCM1.	Arginine	62-70	transcription factor MCM1	Saccharomyces cerevisiae S288C	0-4
29107294-6	2017	RESULTS: Amino acids such as Arg, Lys, and Ala evoke Ca2+ signals in tanycytes and evoke the release of ATP via pannexin 1 and CalHM1, which amplifies the signal via a P2 receptor dependent mechanism.	Arginine	29-32	calcium homeostasis modulator 1	Mus musculus	127-133
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	105-115	transcobalamin 1	Homo sapiens	257-260
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	117-122	transcobalamin 1	Homo sapiens	257-260
3066908-11	1988	MCM1 has striking homology to ARG80, a regulatory gene of the arginine metabolic pathway located about 700 base-pairs upstream from MCM1.	Arginine	62-70	Arg80p	Saccharomyces cerevisiae S288C	30-35
3066908-11	1988	MCM1 has striking homology to ARG80, a regulatory gene of the arginine metabolic pathway located about 700 base-pairs upstream from MCM1.	Arginine	62-70	transcription factor MCM1	Saccharomyces cerevisiae S288C	132-136
28724665-4	2017	Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function.Results: A CSF1R c.1085A&gt;G genetic variant causing the change of histidine to arginine in the domain of receptor dimerization was identified as a high allele frequency in Eastern Asian population.	Arginine	212-220	colony stimulating factor 1	Homo sapiens	142-146
3056747-5	1988	The other (p23) corresponds to 155 amino acids from the 98th Gln to the 252nd Ser, plus five amino acids (Gly-Gly-Thr-Arg-Arg) at the C-terminus, plus 21 amino acids from the H-ras gene at the N-terminus.	Arginine	118-121	RAS related	Homo sapiens	11-14
28985504-5	2017	Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.	Arginine	198-206	argininosuccinate synthase 1	Homo sapiens	102-128
28985504-5	2017	Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.	Arginine	198-206	argininosuccinate synthase 1	Homo sapiens	130-134
28985504-5	2017	Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.	Arginine	198-206	argininosuccinate synthase 1	Homo sapiens	150-154
3056747-5	1988	The other (p23) corresponds to 155 amino acids from the 98th Gln to the 252nd Ser, plus five amino acids (Gly-Gly-Thr-Arg-Arg) at the C-terminus, plus 21 amino acids from the H-ras gene at the N-terminus.	Arginine	122-125	RAS related	Homo sapiens	11-14
3403526-2	1988	The relationship between chemical modifications of arginine derivatives and inhibitory activity to horse serum cholinesterase (BuChE) was investigated.	Arginine	51-59	butyrylcholinesterase	Homo sapiens	111-125
28963509-4	2017	Of sequence-related properties studied, relative lysine to arginine content was found to be higher in CH1 and CL than in variable domains.	Arginine	59-67	SUN domain containing ossification factor	Homo sapiens	102-105
3294332-0	1988	Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of Leishmania promastigotes.	Arginine	45-48	leishmanolysin like peptidase	Homo sapiens	110-114
29018805-4	2017	We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing protein that shares the same consensus binding motif as Grb7.	Arginine	19-27	growth factor receptor bound protein 7	Homo sapiens	60-64
29018805-4	2017	We identified that arginine 462 in the BC loop is unique to Grb7 compared to Grb2, another SH2 domain bearing protein that shares the same consensus binding motif as Grb7.	Arginine	19-27	growth factor receptor bound protein 7	Homo sapiens	166-170
29018805-5	2017	Using surface plasmon resonance we demonstrated that Grb7-SH2 binding to G7-18NATE is reduced 3.3-fold when the arginine is mutated to the corresponding Grb2 amino acid.	Arginine	112-120	growth factor receptor bound protein 7	Homo sapiens	53-57
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	SIN3 transcription regulator family member A	Homo sapiens	39-44
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	argininosuccinate synthase 1	Homo sapiens	118-122
3289620-6	1988	NH2-terminal sequence analyses of the released peptides showed that the 56K proteinase cleaved the fibronectin between the Arg-Thr (located at two different sites), Leu-Ser and Gln-Glu bonds.	Arginine	123-126	fibronectin 1	Bos taurus	99-110
28883660-0	2017	Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1alpha Degradation at the ASS1 promoter for ASS1 Derepression.	Arginine	60-68	argininosuccinate synthase 1	Homo sapiens	136-140
28883660-1	2017	Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg).	Arginine	86-94	argininosuccinate synthase 1	Homo sapiens	0-30
28883660-1	2017	Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg).	Arginine	86-94	argininosuccinate synthase 1	Homo sapiens	32-36
3260695-1	1988	Antithrombin III (AT III) inhibits thrombin via an arginine-serine interaction.	Arginine	51-59	serpin family C member 1	Homo sapiens	0-16
28883660-1	2017	Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg).	Arginine	0-3	argininosuccinate synthase 1	Homo sapiens	32-36
28883660-2	2017	ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth.	Arginine	90-93	argininosuccinate synthase 1	Homo sapiens	0-4
28883660-4	2017	Resistance to Arg starvation is often developed through reactivation of ASS1 expression.	Arginine	14-17	argininosuccinate synthase 1	Homo sapiens	72-76
28883660-5	2017	We previously demonstrated that ASS1 silencing is controlled by HIF-1alpha and Arg starvation-reactivated ASS1 is associated with HIF-1alpha downregulation.	Arginine	79-82	argininosuccinate synthase 1	Homo sapiens	32-36
28883660-5	2017	We previously demonstrated that ASS1 silencing is controlled by HIF-1alpha and Arg starvation-reactivated ASS1 is associated with HIF-1alpha downregulation.	Arginine	79-82	argininosuccinate synthase 1	Homo sapiens	106-110
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	SIN3 transcription regulator family member A	Homo sapiens	78-83
28883660-9	2017	Arg starvation induces p300 dissociation, allowing histone HDAC2 and cofactor Sin3A to deacetylate these histones at the ASS1 promoter, thereby facilitating HIF-1alpha-proteasomal complex, driven by PHD2, to degrade HIF-1alpha in situ.	Arginine	0-3	argininosuccinate synthase 1	Homo sapiens	121-125
3260695-1	1988	Antithrombin III (AT III) inhibits thrombin via an arginine-serine interaction.	Arginine	51-59	serpin family C member 1	Homo sapiens	18-24
2830279-6	1988	The levitide precursor shows a striking nucleotide and amino acid (86%) sequence homology with the precursor of xenopsin, a biologically active octapeptide from Xenopus skin, and also encodes a 25-residue amphipathic peptide that is released by processing at a single arginine residue.	Arginine	268-276	levitude gene 2 L homeolog	Xenopus laevis	112-120
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	glutathione S-transferase kappa 1	Homo sapiens	86-91
3066674-5	1988	It was found that a significant proportion of human granulocyte-macrophage colony stimulating factor was degraded by the yeast KEX2 protease that was cleaving after the dibasic sequence Arg-Arg at positions 23-24 of the mature protein.	Arginine	186-189	colony stimulating factor 2	Homo sapiens	52-100
3066674-5	1988	It was found that a significant proportion of human granulocyte-macrophage colony stimulating factor was degraded by the yeast KEX2 protease that was cleaving after the dibasic sequence Arg-Arg at positions 23-24 of the mature protein.	Arginine	190-193	colony stimulating factor 2	Homo sapiens	52-100
28962167-8	2017	PEPCK mRNA and G-6-Pase mRNA expression levels in the offspring of the IUGR group were higher compared with those in the CON group but were downregulated following L-Arg supplementation.	Arginine	164-169	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	15-23
3442671-0	1987	Chemical modification of a functional arginine residue of rat liver glycine methyltransferase.	Arginine	38-46	glycine N-methyltransferase	Rattus norvegicus	68-93
28726391-8	2017	This substitution disrupts the cation-pi stacking interaction between Arg-259 and Trp-227, which is indispensable for proper assembly of the substrate-binding loops in caspase-6.	Arginine	70-73	caspase 6	Homo sapiens	168-177
2959567-4	1987	By site specific mutagenesis, we have shown that the arginine at the fourth position of IL-1 is one of the key residues in the function of IL-1.	Arginine	53-61	interleukin 1 alpha	Homo sapiens	88-92
28834720-12	2017	Variants of TP2 with shorter and longer arginine side-chain analogs translocate slower than TP2.	Arginine	40-48	transition protein 2	Homo sapiens	12-15
2959567-4	1987	By site specific mutagenesis, we have shown that the arginine at the fourth position of IL-1 is one of the key residues in the function of IL-1.	Arginine	53-61	interleukin 1 alpha	Homo sapiens	139-143
3116090-3	1987	In these studies, we have examined the ability of C5a and C5a des Arg to induce IL-1 production in vitro.	Arginine	66-69	interleukin 1 alpha	Homo sapiens	80-84
28801457-0	2017	Correction for Yu et al., "A Mouse PRMT1 Null Allele Defines an Essential Role for Arginine Methylation in Genome Maintenance and Cell Proliferation".	Arginine	83-91	protein arginine N-methyltransferase 1	Mus musculus	35-40
3116090-4	1987	Human C5a and C5a des Arg were purified to homogeneity and were found to stimulate IL-1 release from freshly obtained human mononuclear cells into the extracellular medium.	Arginine	22-25	interleukin 1 alpha	Homo sapiens	83-87
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	91-94	phosphatase and tensin homolog	Homo sapiens	356-360
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	224-227	phosphatase and tensin homolog	Homo sapiens	119-123
3116090-6	1987	The minimal concentration of C5a required was 25 ng/ml, whereas 125 ng/ml of C5a des Arg induced comparable amounts of IL-1.	Arginine	85-88	interleukin 1 alpha	Homo sapiens	119-123
3106550-6	1987	BALB/c apoA-II contains one residue each of histidine and arginine, neither of which are found in the human A-II protein.	Arginine	58-66	apolipoprotein A2	Homo sapiens	7-14
3105932-1	1987	The enzyme sequentially converts creatine kinase MM3 to MM2 and MM1 and hydrolyzes lysine and arginine from hippuryl-L-lysine and hippuryl-L-arginine.	Arginine	94-102	plexin B2	Homo sapiens	64-67
28792792-6	2017	In this regard, the sequences of six new synthetic IL-24s that have been modified by RGD (Arg-Gly-Asp) or NGR (CRNGRGPDC) were aligned and their structures were modeled through homology modeling to evaluate their attachment potential to cognate receptor complexes such as IL-20R1/IL-20R2, IL-22R1/IL-20R2, or Sig1R.	Arginine	90-93	interleukin 24	Homo sapiens	51-56
28586010-0	2017	Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1.	Arginine	29-39	sirtuin 1	Mus musculus	100-105
28586010-0	2017	Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1.	Arginine	29-39	transformation related protein 53, pseudogene	Mus musculus	132-135
28586010-9	2017	These data suggest that resveratrol protects against L-arginine-induced ANP, which may be related to the enhancement of SIRT1-mediated deacetylation of p53 and HSF1.	Arginine	53-63	sirtuin 1	Mus musculus	120-125
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Arginine	184-187	fibronectin 1	Mus musculus	61-72
28586010-9	2017	These data suggest that resveratrol protects against L-arginine-induced ANP, which may be related to the enhancement of SIRT1-mediated deacetylation of p53 and HSF1.	Arginine	53-63	transformation related protein 53, pseudogene	Mus musculus	152-155
28644004-6	2017	Our studies found that acylations of H4K5 resulted in decreased levels of arginine methylation by PRMT1, PRMT3, and PRMT8.	Arginine	74-82	protein arginine methyltransferase 8	Homo sapiens	116-121
28644004-9	2017	There was a small increase in the rate of arginine methylation by PRMT8.	Arginine	42-50	protein arginine methyltransferase 8	Homo sapiens	66-71
2428041-4	1986	In this study we report that the outgrowth of blastocysts on fibronectin-coated dishes is inhibited in a dose-dependent manner by the presence of a hexapeptide containing the sequence Arg-Gly-Asp, which has been shown previously to be recognized by the fibronectin receptor.	Arginine	184-187	fibronectin 1	Mus musculus	253-264
2427157-1	1986	The localization of methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity in the medullospinal liquor-contacting neurons (LCNs) of the rat was immunohistochemically investigated using a modified Sternberger"s PAP method.	Arginine	42-45	proenkephalin	Rattus norvegicus	31-41
28472221-1	2017	Peptidylarginine deiminase 4 (PADI4), a new histone modification enzyme, which converts both arginine and monomethyl-arginine to citrulline, has gained massive attention in recent years as a potential regulator of gene transcription.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-35
28472221-2	2017	Recent studies have shown that arginine residues R2, R8, R17, and R26 in the H3 tail and R3 in the H4 tail can be deiminated by PADI4.	Arginine	31-39	peptidyl arginine deiminase 4	Homo sapiens	128-133
2427157-1	1986	The localization of methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu)-like immunoreactivity in the medullospinal liquor-contacting neurons (LCNs) of the rat was immunohistochemically investigated using a modified Sternberger"s PAP method.	Arginine	42-45	proenkephalin	Rattus norvegicus	62-65
2427157-2	1986	In this study, we also examined the distribution of Met-Enk-Arg-Gly-Leu-like immunoreactive LCNs in the entire length of the medulla oblongata and spinal cord.	Arginine	60-63	proenkephalin	Rattus norvegicus	56-59
2427157-7	1986	When the immunoreactivity of perikarya of LCNs was weak, a few nerve terminals with a strong Met-Enk-Arg-Gly-Leu-like immunoreactivity were noticed on them.	Arginine	101-104	proenkephalin	Rattus norvegicus	97-100
2427157-8	1986	These findings suggest that preproenkephalin A-related opioid peptides including Met-Enk-Arg-Gly-Leu may be secreted into the cerebrospinal fluid (CSF) through the terminal portions of axon-like processes and/or CSF-contacting processes of LCNs.	Arginine	89-92	proenkephalin	Rattus norvegicus	85-88
28954469-2	2017	Our current study was aimed to explore the effect of L-arginine on skin fibroblast (L929) signaling pathways involved in cell proliferation (Akt-pAkt kinase, Erk/pErk1/2 kinase, JNK/pJNK kinase and pStat-1), apoptosis (Bcl2 and Bax) and immune defense (NF-kappaB and CD26).	Arginine	53-63	dipeptidylpeptidase 4	Mus musculus	267-271
3754413-3	1986	Both antithrombin and heparin cofactor activities of heparin cofactor II are inactivated by the arginine-specific reagent, 2,3-butanedione.	Arginine	96-104	serpin family C member 1	Homo sapiens	5-17
28954469-6	2017	L-arginine was able to elicit NF-kappaB signaling through the increase of p65 active subunit level (p&lt;0.004), while CD26 surface antigen level was not significantly changed.	Arginine	0-10	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	74-77
28316028-2	2017	The uPAR-targeting peptide AE105-NH2 (Ac-Asp-Cha-Phe-(D)Ser-(D)Arg-Tyr-Leu-Trp-Ser-CONH2) is a promising candidate for non-invasive positron emission tomography (PET) imaging of uPAR.	Arginine	63-66	plasminogen activator, urokinase receptor	Homo sapiens	4-8
3889695-3	1985	The enzyme specifically cleaved the Lys-Arg bonds of two synthetic peptides containing the subsequence of proenkephalin A, but endogenous opioid peptides containing a single basic residue in the molecule [Met)enk-Arg-Phe, (Met)enk-Arg-Gly-Leu) were not affected by the enzyme.	Arginine	40-43	proenkephalin	Bos taurus	106-121
28545736-4	2017	Much like IDO1, arginase 1 (Arg1) is an immunoregulatory enzyme that catalyzes the degradation of arginine.	Arginine	98-106	indoleamine 2,3-dioxygenase 1	Homo sapiens	10-14
3881277-4	1985	In the amino acid sequence predicted by the IGF-II variant cDNA, the Ser residue 29 in the B-domain has been replaced by an Arg-Leu-Pro-Gly sequence.	Arginine	124-127	insulin like growth factor 2	Homo sapiens	44-50
28324019-7	2017	We also found that l-arginine upregulated GLUT-1/GLUT-4 expression and translocation, which were related to increased glucose uptake; however, these responses were significantly blocked by N(G)-nitro-l-arginine methylester.	Arginine	19-29	solute carrier family 2 member 4	Rattus norvegicus	49-55
3985748-6	1985	The carboxy-terminal amino acid sequence-Lys-Arg of the fragment was identical to that obtained from colicin M.	Arginine	45-48	Colicin-M	Escherichia coli	101-110
3985748-7	1985	Release of lysine and arginine led to inactivation of colicin M.	Arginine	22-30	Colicin-M	Escherichia coli	54-63
6085024-13	1984	These results suggest that (1) Ala-AP and Pro-EP have large neuronal components, (2) ACE is preferencially localized in neurons and (3) DAP and Arg-EP are associated with glial lysosomal function.	Arginine	144-147	prolyl endopeptidase	Rattus norvegicus	42-48
6442339-7	1984	The cleavage site of pro-apoA-II is characterized by two basic amino acid residues Arg-Arg, present also in other known pro-proteins.	Arginine	83-86	apolipoprotein A2	Homo sapiens	25-32
6442339-7	1984	The cleavage site of pro-apoA-II is characterized by two basic amino acid residues Arg-Arg, present also in other known pro-proteins.	Arginine	87-90	apolipoprotein A2	Homo sapiens	25-32
16453580-4	1984	We suggest that the main function of phosphorylation of sp-Ia and sp-Ib is to provide charge neutralization of an excess of lysine and arginine residues and is therefore required during early stages of protein folding.	Arginine	135-143	Spi-1 proto-oncogene	Homo sapiens	56-71
6511918-4	1984	Resumption of arginine intake (or citrulline in the case of ornithine transcarbamylase deficiency) promptly led to correction of the hyperammonemia, hyperglutaminemia and hypoargininemia.	Arginine	14-22	ornithine transcarbamylase	Homo sapiens	60-86
6466857-2	1984	The evaluation of the degree of the stress and antistressor properties of a hexapeptide arginine-containing analog of leu-enkephalin was performed according to the changes in the weight of the thymus, spleen, adrenals, and appearance of ulceration in the gastric mucosa.	Arginine	88-96	proenkephalin	Rattus norvegicus	122-132
6372096-3	1984	The amino-terminal leader peptide of OTC is 32 amino acids in length and contains four arginines but no acidic residues.	Arginine	87-96	ornithine transcarbamylase	Homo sapiens	37-40
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	47-55	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	47-55	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	47-55	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	296-304	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	296-304	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
6323147-8	1984	These results suggest that the substitution of arginine residue of mammalian LHRH for glutamine residue of chicken LHRH causes a decrease in the binding affinity of the hormone for the mammalian LHRH receptor and that the mammalian LHRH receptor has a binding site for the cationic center of the arginine residue of LHRH.	Arginine	296-304	gonadotropin releasing hormone 1	Rattus norvegicus	115-119
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	23-26	trnY(gua)	Nicotiana tabacum	18-22
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	23-26	trnY(gua)	Nicotiana tabacum	18-22
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	152-155	trnY(gua)	Nicotiana tabacum	4-8
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	152-155	trnY(gua)	Nicotiana tabacum	18-22
16593407-5	1984	The tRNA(Gly) and tRNA(Arg) deduced from the DNA sequences show 84% and 55% sequence homologies with Escherichia coli tRNA(Gly) (UCC) and phage T4 tRNA(Arg) (UCU), respectively.	Arginine	152-155	trnY(gua)	Nicotiana tabacum	18-22
6137956-7	1983	When arginine was used as a secretagogue, PHI (10 nmol/liter) potentiated secretion of insulin, glucagon, and somatostatin.	Arginine	5-13	glucose-6-phosphate isomerase	Rattus norvegicus	42-45
6192448-3	1983	The amino acid composition of the predicted sequence upstream of the tandem arginines matches quite closely with the composition of a similar sized peptide at the COOH terminus of the human C4 alpha chain.	Arginine	76-85	complement C4A (Rodgers blood group)	Homo sapiens	190-198
6852036-3	1983	Porcine pancreatic phospholipase A2 has Arg-Ser at positions 6 and 7, whereas the bovine enzyme has Asn-Gly.	Arginine	40-43	LOC104974671	Bos taurus	19-35
6405734-11	1983	Modification of arginine residues by cyclohexane 1,2-dione and ninhydrin led to complete loss of enterokinase-inhibitory activity.	Arginine	16-24	transmembrane serine protease 15	Sus scrofa	97-109
6670711-1	1983	In a patient with hyperargininemia, oral administration of sodium benzoate or phenylacetic acid together with an essential amino acid mixture was used to prevent hyperammonemia and to decrease plasma and CSF concentrations of arginine.	Arginine	23-31	colony stimulating factor 2	Homo sapiens	204-207
6670711-4	1983	By these treatments, plasma and CSF concentrations of arginine showed a slight decrease, but were far above the normal range.	Arginine	54-62	colony stimulating factor 2	Homo sapiens	32-35
6409360-2	1983	This synthesis, proceeding from arginine, is induced by a soluble protein factor released during secondary MLC, unstable to heat, with a molecular weight of approximately 150,000 daltons.	Arginine	32-40	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	107-110
6629822-3	1983	Structural studies indicated a new variant beta 78 (EF2) Leu replaced by Arg.	Arginine	73-76	eukaryotic translation elongation factor 2	Homo sapiens	52-55
7145171-0	1982	[Behavior of serum gastrin after infusion of arginine in patients with liver diseases.	Arginine	45-53	gastrin	Homo sapiens	19-26
7100893-1	1982	The present paper describes the structural analysis of an abnormal hemoglobin variant of alpha-chain found in a Chinese woman in the Hechi district of the Zhuang Autonomous Region of Guangxi, and finds it to be hemoglobin Handsworth (alpha 18(A16) Gly leads to Arg).	Arginine	261-264	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	243-246
6172555-4	1981	Amino acid analysis of P19 disclosed a high content of arginine (12.9%), leucine (11.9%), serine (10.3%) and proline (10.2%).	Arginine	55-63	interleukin 23 subunit alpha	Homo sapiens	23-26
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	91-99	argininosuccinate synthetase 1	Mus musculus	13-41
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	91-99	argininosuccinate synthetase 1	Mus musculus	43-47
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	91-99	transformation related protein 53, pseudogene	Mus musculus	150-153
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	221-229	argininosuccinate synthetase 1	Mus musculus	13-41
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	221-229	argininosuccinate synthetase 1	Mus musculus	43-47
28560349-4	2017	We show that argininosuccinate synthase 1 (ASS1), a citrulline-aspartate ligase in de novo arginine synthesis pathway, was directly transactivated by p53 in response to genotoxic stress, resulting in the rearrangement of arginine metabolism.	Arginine	221-229	transformation related protein 53, pseudogene	Mus musculus	150-153
28560349-5	2017	Furthermore, we found that x-ray irradiation promoted the systemic induction of Ass1 and concomitantly increased plasma arginine levels in p53+/+ mice but not in p53-/- mice.	Arginine	120-128	transformation related protein 53, pseudogene	Mus musculus	139-142
6118269-0	1981	Reactivity of D-amino acid oxidase with 1,2-cyclohexanedione: evidence for one arginine in the substrate-binding site.	Arginine	79-87	D-amino acid oxidase	Homo sapiens	14-34
6118269-10	1981	The presence of benzoate, while it prevents the loss of activity, reduces by one the number of arginine residues hit by the reagent in the reaction of 1,2-cyclohexanedione with D-amino acid oxidase.	Arginine	95-103	D-amino acid oxidase	Homo sapiens	177-197
7311080-0	1981	[The inhibitory effect of sulpiride on arginine-stimulated serum gastrin and growth hormone in normal subjects and peptic ulcer patients (author"s transl)].	Arginine	39-47	gastrin	Homo sapiens	65-72
28437098-3	2017	Our binding experiments with the (beta15-66)2 fragment, which corresponds to a pair of fibrin betaN-domains, and the VLDLR(1-8) fragment, consisting of eight CR domains of VLDLR, revealed that interaction between them strongly depends on ionic strength and chemical modification of all Lys or Arg residues in (beta15-66)2 results in abrogation of this interaction.	Arginine	293-296	very low density lipoprotein receptor	Homo sapiens	117-122
28437098-3	2017	Our binding experiments with the (beta15-66)2 fragment, which corresponds to a pair of fibrin betaN-domains, and the VLDLR(1-8) fragment, consisting of eight CR domains of VLDLR, revealed that interaction between them strongly depends on ionic strength and chemical modification of all Lys or Arg residues in (beta15-66)2 results in abrogation of this interaction.	Arginine	293-296	very low density lipoprotein receptor	Homo sapiens	172-177
28437098-6	2017	The results obtained suggest that interaction between fibrin and the VLDL receptor employs the "double-Lys/Arg" recognition mode previously proposed for the interaction of the LDL receptor family members with their ligands.	Arginine	107-110	very low density lipoprotein receptor	Homo sapiens	69-82
7021390-0	1981	Effect of glucose and arginine on L-enkephalin secretion of the isolated perfused rat pancreas.	Arginine	22-30	proenkephalin	Rattus norvegicus	36-46
28341883-2	2017	In many bacteria, NAGK catalysis is the rate controlling step in the L-arginine biosynthesis pathway from glutamate to L-arginine and is allosterically inhibited by L-arginine.	Arginine	69-79	N-acetylglucosamine kinase	Homo sapiens	18-22
28341883-2	2017	In many bacteria, NAGK catalysis is the rate controlling step in the L-arginine biosynthesis pathway from glutamate to L-arginine and is allosterically inhibited by L-arginine.	Arginine	119-129	N-acetylglucosamine kinase	Homo sapiens	18-22
28341883-2	2017	In many bacteria, NAGK catalysis is the rate controlling step in the L-arginine biosynthesis pathway from glutamate to L-arginine and is allosterically inhibited by L-arginine.	Arginine	119-129	N-acetylglucosamine kinase	Homo sapiens	18-22
6160579-3	1980	The NH2 terminus was determined to be NH2-Met1-Ser-Tyr-Asn-Leu-Leu-Gly-Phe-Leu-Gln-Arg-Ser-Ser-Asn-Phe-Gln-X-Gln-Lys.	Arginine	83-86	granzyme M	Homo sapiens	42-46
28341883-5	2017	Due to the lack of NAGK catalysis step in arginine synthesis route of mammals, the elucidation of the dynamic mechanism can also provide a way to design a new antivirus drug.	Arginine	42-50	N-acetylglucosamine kinase	Homo sapiens	19-23
7213342-11	1980	The results indicate that during formation of the antithrombin III--thrombin complex, the inhibitor is cleaved at an arginine--X bond; this arginine residue forms a carboxylic ester with the enzyme, while the excised polypeptide remains bound through a disulphide bridge(s).	Arginine	117-125	serpin family C member 1	Homo sapiens	50-66
28029744-9	2017	Both enzymes hypercitrullinated fibrinogen, but PAD4 citrullinated arginines more intermittently, generating a mix of citrullinated and noncitrullinated arginines.	Arginine	67-76	peptidyl arginine deiminase 4	Homo sapiens	48-52
28029744-9	2017	Both enzymes hypercitrullinated fibrinogen, but PAD4 citrullinated arginines more intermittently, generating a mix of citrullinated and noncitrullinated arginines.	Arginine	153-162	peptidyl arginine deiminase 4	Homo sapiens	48-52
7213342-11	1980	The results indicate that during formation of the antithrombin III--thrombin complex, the inhibitor is cleaved at an arginine--X bond; this arginine residue forms a carboxylic ester with the enzyme, while the excised polypeptide remains bound through a disulphide bridge(s).	Arginine	140-148	serpin family C member 1	Homo sapiens	50-66
7190836-3	1980	The rates of hydrolysis of the Arg-Gly bond in these peptides by thrombin were measured, and the values of the specificity constant, kcat/KM, were all found to be approximately 2 X 10(-7) [(NIH unit/L)s]-1, similar to that for a peptide (F-3) having an additional Arg residue between Glu- and -NHCH3 of F-4.	Arginine	31-34	coagulation factor III, tissue factor	Bos taurus	238-241
28250123-4	2017	To elucidate the structural requirements within the NS1 protein for PKR inhibition, we generated a set of mutant viruses, identifying highly conserved arginine residues 35 and 46 within the NS1 N terminus as being most critical not only for binding to and blocking activation of PKR but also for efficient virus propagation.	Arginine	151-159	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	68-71
28250123-10	2017	Using mutational analysis, we identified arginine residues 35 and 46 within the N-terminal NS1 domain as highly critical for binding to and functional silencing of PKR.	Arginine	41-49	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	164-167
6104918-2	1980	Repeated arginine pulses given at 30-minute intervals caused abrupt and almost identical rises of plasma gastrin with each pulse.	Arginine	9-17	gastrin	Homo sapiens	105-112
28382930-4	2017	Substitution of the active site binding arginine of CP2 to N-e-trimethyl-lysine or methylated arginine results in cyclic peptide substrates, indicating that KDM4s may act on non-histone substrates.	Arginine	40-48	ceruloplasmin	Homo sapiens	52-55
6104918-4	1980	The increase in plasma gastrin induced by arginine pulse was significantly suppressed by the infusion of beta-adrenergic blocking agent, propranolol, while the infusion of alpha-adrenergic blocking agent, phentolamine tended to enhance the arginine-induced gastrin secretion slightly but not significantly.	Arginine	42-50	gastrin	Homo sapiens	23-30
6988672-2	1980	Mutants designated ilv 1-OPc map in this control region located between arg 6 and ilv 1 and result in increased basal levels and constitutive synthesis of the ilv 1 gene products.	Arginine	72-75	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	19-24
526090-2	1979	Insulin, gastrin and glucagon responses to oral glucose and intravenous arginine in peptic ulcer patients.	Arginine	72-80	gastrin	Homo sapiens	9-16
383231-3	1979	Incubation of these cells in the presence of the arginine analogue, L-canavanine, resulted in the inhibition of conversion of newly formed proinsulin to insulin and the appearance of a radioactive component of molecular weight 11,000-12,000.	Arginine	49-57	insulin	Bos taurus	139-149
27355867-9	2017	Altogether, these data suggest that swapping residue 188 identity effectively flips the membrane binding profile of wild-type RhoA and RhoC through positive arginine contribution rather than negative phosphoserine regulation.	Arginine	157-165	ras homolog family member C	Homo sapiens	135-139
27943578-4	2017	We found that oral administration of both L-arginine and L-ornithine significantly increased total plasma GLP-1 levels to a similar level in GPRC6A KO and WT mice 15 minutes after gavage (both amino acids) and accumulated up to 60 minutes after gavage (L-arginine).	Arginine	42-52	G protein-coupled receptor, family C, group 6, member A	Mus musculus	141-147
383231-3	1979	Incubation of these cells in the presence of the arginine analogue, L-canavanine, resulted in the inhibition of conversion of newly formed proinsulin to insulin and the appearance of a radioactive component of molecular weight 11,000-12,000.	Arginine	49-57	insulin	Bos taurus	142-149
736888-13	1978	By treatment of inactivated phosphorylase b with carboxypeptidase B, it was shown that the intestinal muscle proteinase had cleaved approximately 3 -Lys-X and 3 -Arg-X bonds in the polypeptide.	Arginine	162-165	carboxypeptidase B1	Rattus norvegicus	49-67
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Arginine	54-62	sulfite oxidase	Brachypodium distachyon	9-12
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Arginine	54-62	sulfite oxidase	Brachypodium distachyon	107-110
28461726-13	2017	Finally, SOX-sulfite docked structures indicated that arginine residues particularly Arg374 is crucial for SOX-sulfite binding and additional two other residues such as Arg51 and Arg103 may be important for SOX-sulfite bindings in plants.	Arginine	54-62	sulfite oxidase	Brachypodium distachyon	107-110
213127-3	1978	Also, the amino acid arginine would induce ornithine decarboxylase in this cell type following arginine starvation for 24 h. These observations are in contrast to the wide range of hormones, e.g. insulin, hydrocortisone, glucagon and growth hormone, than can induce ornithine decarboxylase in vivo in the adult rat liver but which are all without effect on fetal rat liver cells.	Arginine	21-29	ornithine decarboxylase 1	Rattus norvegicus	43-66
28378970-10	2017	CONCLUSIONS: L-arginine increased the expression of p-53 protein - on the 10th day of pregnancy, which increased at the end of pregnancy; however, 10 days after delivery the level dropped below that observable during physiological pregnancy.	Arginine	13-23	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	52-56
213127-3	1978	Also, the amino acid arginine would induce ornithine decarboxylase in this cell type following arginine starvation for 24 h. These observations are in contrast to the wide range of hormones, e.g. insulin, hydrocortisone, glucagon and growth hormone, than can induce ornithine decarboxylase in vivo in the adult rat liver but which are all without effect on fetal rat liver cells.	Arginine	21-29	ornithine decarboxylase 1	Rattus norvegicus	266-289
28285824-6	2017	We discovered that Reelin regulates several phosphorylation sites within the positively charged serine/arginine-rich region that constitute consensus GSK3beta phosphorylation motifs of CLASP2.	Arginine	103-111	cytoplasmic linker associated protein 2	Homo sapiens	185-191
649256-3	1978	A description is given of the synthesis by fragment condensation of the peptide Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp-Thr-Glu-Gly-Pro-Ser-Lys corresponding to the 1--23 amino acid sequence of rat pancreatic ribonuclease.	Arginine	92-95	ribonuclease A family member 1, pancreatic	Rattus norvegicus	226-249
28238654-6	2017	Taken together, our findings reveal the importance of PRMT5-mediated arginine methylation during DSB repair pathway choice through its ability to regulate acetylation-dependent control of 53BP1 localization.	Arginine	69-77	tumor protein p53 binding protein 1	Homo sapiens	188-193
15835-10	1977	In contrast to cathepsin B1, its capability of hydrolyzing N-substituted derivatives of arginine is low and it does not split esters.	Arginine	88-96	cathepsin B	Rattus norvegicus	15-27
27913198-0	2017	Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.	Arginine	100-108	argininosuccinate synthase 1	Homo sapiens	0-30
185197-1	1976	An arginine regulatory mutant (i.e., mutated in the argR gene) has been isolated from a strain of Salmonella typhimurium LT2.	Arginine	3-11	arginine repressor	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	52-56
27913198-0	2017	Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.	Arginine	100-108	argininosuccinate synthase 1	Homo sapiens	32-36
27913198-1	2017	Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg).	Arginine	101-109	argininosuccinate synthase 1	Homo sapiens	0-30
27913198-1	2017	Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg).	Arginine	101-109	argininosuccinate synthase 1	Homo sapiens	32-36
27913198-1	2017	Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg).	Arginine	0-3	argininosuccinate synthase 1	Homo sapiens	32-36
27913198-2	2017	Many malignant human tumors are auxotrophic for Arg because ASS1 is silenced.	Arginine	48-51	argininosuccinate synthase 1	Homo sapiens	60-64
27913198-3	2017	ASS1 has been established as a sensor of Arg auxotrophic response and a chemosensitivity marker for Arg starvation therapy.	Arginine	41-44	argininosuccinate synthase 1	Homo sapiens	0-4
27913198-3	2017	ASS1 has been established as a sensor of Arg auxotrophic response and a chemosensitivity marker for Arg starvation therapy.	Arginine	100-103	argininosuccinate synthase 1	Homo sapiens	0-4
27913198-5	2017	Knockdown of ASS1 expression resulted in increased sensitivity to both Arg- and Gln-starvation, whereas increased ASS1 expression by ectopic transfection is associated with resistance to both Arg- and Gln-starvation.	Arginine	71-74	argininosuccinate synthase 1	Homo sapiens	13-17
27913198-5	2017	Knockdown of ASS1 expression resulted in increased sensitivity to both Arg- and Gln-starvation, whereas increased ASS1 expression by ectopic transfection is associated with resistance to both Arg- and Gln-starvation.	Arginine	192-195	argininosuccinate synthase 1	Homo sapiens	114-118
27913198-7	2017	Mechanistically, the Gln-deprivation response, like the arginine-auxotrophic response, downregulates HIF-1alpha resulting in de-silencing of ASS1.	Arginine	56-64	argininosuccinate synthase 1	Homo sapiens	141-145
27913198-8	2017	Our results demonstrate that ASS1 is a common biosensor for Arg and Gln deprivation response and a shared target for Arg- and Gln-starvation therapies which have been in several current clinical trials.	Arginine	60-63	argininosuccinate synthase 1	Homo sapiens	29-33
185197-2	1976	The argR mutant was found to excrete arginine into the growth medium with glycerol but not glucose as carbon source.	Arginine	37-45	arginine repressor	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	4-8
162907-5	1975	Serum stimulates arginine uptake in fetal rat liver cells suggesting that serum growth factor(s) act by increasing intracellular arginine levels high enough to initiate the growth cycle.	Arginine	17-25	myotrophin	Rattus norvegicus	80-93
27913198-8	2017	Our results demonstrate that ASS1 is a common biosensor for Arg and Gln deprivation response and a shared target for Arg- and Gln-starvation therapies which have been in several current clinical trials.	Arginine	117-120	argininosuccinate synthase 1	Homo sapiens	29-33
162907-5	1975	Serum stimulates arginine uptake in fetal rat liver cells suggesting that serum growth factor(s) act by increasing intracellular arginine levels high enough to initiate the growth cycle.	Arginine	129-137	myotrophin	Rattus norvegicus	80-93
28004927-8	2017	Four other arginines, Arg285, Arg410, Arg431, and Arg521, were found essential in the stabilization of p100 on the beta-TrCP surface.	Arginine	11-20	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	115-124
5540041-0	1971	The second variant of human myoglobin; 138(H16) arginine leads to glutamine.	Arginine	48-56	myoglobin	Homo sapiens	28-37
28004927-9	2017	Importantly, the requirement for these five arginine residues of beta-TrCP for the interaction with p100 was further confirmed in vivo, thereby validating the docking model through a biological approach.	Arginine	44-52	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	65-74
28214225-1	2017	Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation.	Arginine	118-128	indoleamine 2,3-dioxygenase 1	Homo sapiens	22-51
28214225-1	2017	Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation.	Arginine	118-128	indoleamine 2,3-dioxygenase 1	Homo sapiens	53-57
14058941-7	1963	The conversion of arginine to ornithine in PPLO-contaminated cell culture was rapid, and occurred by the arginine dihydrolase pathway involving arginine deiminase, ornithine transcarbamylase, and carbamyl phosphokinase.	Arginine	18-26	ornithine transcarbamylase	Homo sapiens	164-190
28222195-10	2017	De novo sequencing showed that there was a mutation at either of the SS positions on the CDR1 region, which changed one of the serine residues to a basic amino acid, i.e., arginine or lysine.	Arginine	172-180	cerebellar degeneration related protein 1	Homo sapiens	89-93
33545070-4	2021	Notably, the positively charged lysine-arginine (KR) clusters are responsible for modulating HMGA1a conformation via electrostatic interaction with the phosphorylated acidic tail.	Arginine	39-47	high mobility group AT-hook 1	Homo sapiens	93-99
28137860-3	2017	Glycine amidinotransferase (GATM) catalyzes the rate-limiting step of creatine biosynthesis: the transfer of an amidino group from arginine to glycine to form ornithine and guanidinoacetate.	Arginine	131-139	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	Mus musculus	28-32
33999213-9	2021	We also found that the two major methylation sites known to regulate TOP3B activity are located in the most conserved region of the C-terminal arginine-glycine-glycine (RGG) box, suggesting that a similar regulatory mechanism may operate throughout animals.	Arginine	143-151	DNA topoisomerase III beta	Homo sapiens	69-74
28187218-1	2017	Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	0-30
28187218-1	2017	Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	32-36
33999963-1	2021	Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
28290784-2	2017	This mutation designated c.1327 T&gt;C (W443R [W422R]) was predicted to cause substitution of arginine for tryptophan residue in the very conservative -propeller domain of the LDL receptor.	Arginine	94-102	low density lipoprotein receptor	Homo sapiens	176-188
33982231-8	2021	Reduced miR-494-3p and upregulated HDAC3 and BRD4 exhibited in myocardial tissues of mice with MI/RI and H/R-treated cardiomyocytes.	Arginine	0-1	histone deacetylase 3	Mus musculus	35-40
28122247-2	2017	Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers.	Arginine	0-8	argininosuccinate synthetase 1	Mus musculus	52-82
28122247-2	2017	Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive cancers.	Arginine	0-8	argininosuccinate synthetase 1	Mus musculus	84-88
33982231-8	2021	Reduced miR-494-3p and upregulated HDAC3 and BRD4 exhibited in myocardial tissues of mice with MI/RI and H/R-treated cardiomyocytes.	Arginine	0-1	bromodomain containing 4	Mus musculus	45-49
33529715-1	2021	BACKGROUND: Protein arginine deiminase 4 (PAD4) is an enzyme capable of converting arginine (positively charged residue) into citrulline (neutral residue).	Arginine	20-28	peptidyl arginine deiminase 4	Homo sapiens	42-46
28101374-0	2017	Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.	Arginine	0-8	ubiquitin specific peptidase 9, X chromosome	Mus musculus	24-29
28101374-0	2017	Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.	Arginine	0-8	tudor domain containing 3	Mus musculus	60-65
28101374-2	2017	The Tudor domain-containing protein 3 (TDRD3) is one of the major methyl-arginine effector molecules that recognizes methylated arginine residues on histones and the C-terminal domain of RNA polymerase II, and activates transcription.	Arginine	73-81	tudor domain containing 3	Mus musculus	4-37
28101374-2	2017	The Tudor domain-containing protein 3 (TDRD3) is one of the major methyl-arginine effector molecules that recognizes methylated arginine residues on histones and the C-terminal domain of RNA polymerase II, and activates transcription.	Arginine	73-81	tudor domain containing 3	Mus musculus	39-44
28101374-5	2017	Detailed characterization suggests that the interaction between TDRD3 and USP9X is mediated through the Tudor domain of TDRD3 and the arginine methylation of USP9X.	Arginine	134-142	tudor domain containing 3	Mus musculus	64-69
28101374-5	2017	Detailed characterization suggests that the interaction between TDRD3 and USP9X is mediated through the Tudor domain of TDRD3 and the arginine methylation of USP9X.	Arginine	134-142	ubiquitin specific peptidase 9, X chromosome	Mus musculus	74-79
28101374-5	2017	Detailed characterization suggests that the interaction between TDRD3 and USP9X is mediated through the Tudor domain of TDRD3 and the arginine methylation of USP9X.	Arginine	134-142	ubiquitin specific peptidase 9, X chromosome	Mus musculus	158-163
33529715-6	2021	The kinetics of citrullination of PAD4 and citrullinated PAD4 (citPAD4) towards substrates of different sizes (0.17-15.4 kDa), i,e free arginine, a peptidyl substrate, and histone H3, were studied by colorimetric assay and Western blotting.	Arginine	136-144	peptidyl arginine deiminase 4	Homo sapiens	34-38
33529715-6	2021	The kinetics of citrullination of PAD4 and citrullinated PAD4 (citPAD4) towards substrates of different sizes (0.17-15.4 kDa), i,e free arginine, a peptidyl substrate, and histone H3, were studied by colorimetric assay and Western blotting.	Arginine	136-144	peptidyl arginine deiminase 4	Homo sapiens	57-61
33529715-8	2021	RESULTS: We observed that 23/27 arginine residues in PAD4 (85%) can be citrullinated, including R372, R374 and R639 located near the substrate binding pocket.	Arginine	32-40	peptidyl arginine deiminase 4	Homo sapiens	53-57
33906789-2	2021	KIR2DL1 allotypes with cysteine at position-245 (KIR2DL1-C245) express at lower levels and demonstrate weaker inhibitory signaling compared to allotypes with arginine at position-245 (KIR2DL1-R245).	Arginine	158-166	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	0-7
28381806-2	2017	During the terminal differentiation stage of immature cuticular cells within the hair follicle, cysteine-rich calcium binding S100A3 protein is predominantly translated, and its arginine residues are converted to citrullines by peptidylarginine deiminases (PADI).	Arginine	178-186	S100 calcium binding protein A3	Homo sapiens	126-132
33884581-9	2021	Overall, these results reveal an additional therapeutic mechanism of action of clozapine: this drug posttranslationally inhibits the degradation of Arg/N-degron substrates, including RGS4.	Arginine	148-151	regulator of G-protein signaling 4	Rattus norvegicus	183-187
27584578-1	2017	Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	90-120
27584578-1	2017	Importance: Preclinical studies show that arginine deprivation is synthetically lethal in argininosuccinate synthetase 1 (ASS1)-negative cancers, including mesothelioma.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	122-126
33051101-0	2021	Use of l-arginine-assisted ultrasonic treatment to change the molecular and interfacial characteristics of fish myosin and enhance the physical stability of the emulsion.	Arginine	7-17	myosin heavy chain 14	Homo sapiens	112-118
28854440-7	2017	The expression levels of Nrf2, HO-1, and HSP70 were strongly increased, and the expression of NF-kappaB and production of ROS were significantly decreased in the L-arginine group compared to that of the I/R group.	Arginine	162-172	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	41-46
33051101-1	2021	The effects of l-arginine (Arg)-assisted ultrasonic treatment on the molecular and interfacial characteristics of myosin and emulsifying properties of the emulsion were evaluated to ascertain the underlying mechanism in improving the emulsion stability.	Arginine	15-25	myosin heavy chain 14	Homo sapiens	114-120
28854440-9	2017	CONCLUSION: These findings suggested that L-arginine/NO reduces renal dysfunction associated with I/R of the kidney and may act as a trigger to regulate the NF-kappaB, HSP70 and Nrf2/HO-1 signaling cascades.	Arginine	42-52	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	168-173
33051101-1	2021	The effects of l-arginine (Arg)-assisted ultrasonic treatment on the molecular and interfacial characteristics of myosin and emulsifying properties of the emulsion were evaluated to ascertain the underlying mechanism in improving the emulsion stability.	Arginine	27-30	myosin heavy chain 14	Homo sapiens	114-120
27893431-3	2016	A Tdp1Hisgab to Arg mutant identified in patients with the autosomal recessive neurodegenerative disease SCAN1 causes stabilization of the TDP1-DNA intermediate.	Arginine	16-19	calcium activated nucleotidase 1	Homo sapiens	105-110
33051101-2	2021	Ultrasonication induced the exposure of residues of native myosin, which was increased by the addition of Arg (40 mM).	Arginine	106-109	myosin heavy chain 14	Homo sapiens	59-65
33051101-4	2021	Moreover, the increase in the ordered structures of interfacial myosin induced by Arg and ultrasonication favoured the formation of a protein gelation network.	Arginine	82-85	myosin heavy chain 14	Homo sapiens	64-70
28002734-6	2016	Domain-substitution and mutagenesis experiments further demonstrate that arginines surrounding the phosphorylated SF1 loop are required for cooperative 3" splice site recognition by the SF1-U2AF65 complex (where cooperativity is defined as a nonadditive increase in RNA binding by the protein complex relative to the individual proteins).	Arginine	73-82	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	190-196
33051101-5	2021	In summary, Arg-assisted ultrasonic treatment improved the stability of the emulsion by inducing the exposure of native myosin and facilitating the formation of ordered structures of interfacial myosin.	Arginine	12-15	myosin heavy chain 14	Homo sapiens	120-126
33051101-5	2021	In summary, Arg-assisted ultrasonic treatment improved the stability of the emulsion by inducing the exposure of native myosin and facilitating the formation of ordered structures of interfacial myosin.	Arginine	12-15	myosin heavy chain 14	Homo sapiens	195-201
33856599-2	2021	Preclinical studies showed that HCC is reliant on exogenous arginine for growth due to the under-expression of the arginine regenerating enzymes argininosuccinate synthetase (ASS) and ornithine transcarbamylase (OTC).	Arginine	60-68	ornithine transcarbamylase	Homo sapiens	184-210
27958343-2	2016	Arginine-deficient ARD mutants preferentially encapsidated spliced viral RNA and shorter DNA, which can be fully or partially rescued by reducing the negative charges from acidic residues or serine phosphorylation of HBc, dose-dependently.	Arginine	0-8	keratin 88, pseudogene	Homo sapiens	217-220
33508432-1	2021	Argininosuccinate synthase 1 (ASS1) serves as a critical enzyme in arginine biosynthesis; however, its role in interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF), remains largely unknown.	Arginine	67-75	argininosuccinate synthase 1	Homo sapiens	0-28
27839948-4	2016	We investigated the functional impact of two natural anemia-causing glycine-to-arginine mutations that impaired transition metal transport in both human Nramp2 and DraNramp.	Arginine	79-87	solute carrier family 11 member 2	Homo sapiens	153-159
33508432-1	2021	Argininosuccinate synthase 1 (ASS1) serves as a critical enzyme in arginine biosynthesis; however, its role in interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF), remains largely unknown.	Arginine	67-75	argininosuccinate synthase 1	Homo sapiens	30-34
33683322-7	2021	Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing angiotensin 1-7 and activating the MasR while blocking angiotensin III formation, contributes to the antihypertensive effect and the decrease in arginine-vasopressin release induced by RB150/firibastat.	Arginine	300-308	glutamyl aminopeptidase	Rattus norvegicus	85-88
27548707-3	2016	Here, we show that chromatin deformation as well as force-induced transcription of a green fluorescent protein (GFP)-tagged bacterial-chromosome dihydrofolate reductase (DHFR) transgene can be visualized in a living cell by using three-dimensional magnetic twisting cytometry to apply local stresses on the cell surface via an Arg-Gly-Asp-coated magnetic bead.	Arginine	327-330	dihydrofolate reductase	Homo sapiens	145-168
27548707-3	2016	Here, we show that chromatin deformation as well as force-induced transcription of a green fluorescent protein (GFP)-tagged bacterial-chromosome dihydrofolate reductase (DHFR) transgene can be visualized in a living cell by using three-dimensional magnetic twisting cytometry to apply local stresses on the cell surface via an Arg-Gly-Asp-coated magnetic bead.	Arginine	327-330	dihydrofolate reductase	Homo sapiens	170-174
27423267-0	2016	Blood-brain barrier penetration of an Abeta-targeted, arginine-rich, d-enantiomeric peptide.	Arginine	54-62	amyloid beta (A4) precursor protein	Mus musculus	38-43
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	peptidyl arginine deiminase 1	Homo sapiens	47-52
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	peptidyl arginine deiminase 1	Homo sapiens	54-82
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	pyruvate kinase M1/2	Homo sapiens	221-239
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	pyruvate kinase M1/2	Homo sapiens	241-245
33741961-7	2021	We provide insight as to how conversion of arginines to citrulline impacts key interactions within PKM2 that act in concert to reprogramme its activity as an additional mechanism regulating this important enzyme.	Arginine	43-52	pyruvate kinase M1/2	Homo sapiens	99-103
27741237-2	2016	Transforming growth factor-beta-inducible gene-h3 (betaig-h3), which consists of four fas-1 domains and an Arg-Gly-Asp (RGD) motif, intensifies inflammatory processes by facilitating adhesion and migration of fibroblast-like synoviocyte in the pathogenesis of rheumatoid arthritis (RA).	Arginine	107-110	transforming growth factor, beta induced	Mus musculus	51-60
33739886-8	2021	The possible PCB interaction with Sox4 transcriptional protein was confirmed through molecular docking where three hydrogen bonds were formed at ARG and LYS residues at a stable binding energy of -4.72.	Arginine	145-148	SRY (sex determining region Y)-box 4	Mus musculus	34-38
27353886-4	2016	Although non-peptidic in nature, these inhibitors mimic key features of the uncleavable substrate peptide Arg-Ile-Met-Glu (RIME) of the SNAP-25 protein.	Arginine	106-109	synaptosome associated protein 25	Homo sapiens	136-143
27247266-0	2016	The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.	Arginine	89-97	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	35-39
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	29-37	argininosuccinate lyase	Bos taurus	234-257
27470910-7	2016	In the ARG, the osteoblasts viability, TGF-beta1, BMP-2, IGF-I and Cbfalpha1 mRNA expressions and the GSH-Px and SOD activities were significantly increased, the ROS concentration was significantly decreased, and osteoblasts histology lesion was attenuated compared with the AG.	Arginine	7-10	insulin-like growth factor 1	Rattus norvegicus	57-62
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	74-82	argininosuccinate lyase	Bos taurus	234-257
33338599-2	2021	This phenomenon, termed the "arginine paradox" led to the discovery of an arginine recycling pathway in which L-citrulline is recycled to L-arginine by utilizing two important urea cycle enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	138-148	argininosuccinate lyase	Bos taurus	234-257
26913960-2	2016	Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginosuccinate synthetase or ornithine transcarbamylase-key enzymes for intracellular arginine recycling.	Arginine	0-8	ornithine transcarbamylase	Homo sapiens	126-152
26913960-2	2016	Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginosuccinate synthetase or ornithine transcarbamylase-key enzymes for intracellular arginine recycling.	Arginine	57-65	ornithine transcarbamylase	Homo sapiens	126-152
34027271-1	2021	Protein arginine methyl transferase 1 (PRMT1) is the main enzyme for cellular arginine methylation.	Arginine	8-16	protein arginine N-methyltransferase 1	Mus musculus	39-44
26913960-2	2016	Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginosuccinate synthetase or ornithine transcarbamylase-key enzymes for intracellular arginine recycling.	Arginine	183-191	ornithine transcarbamylase	Homo sapiens	126-152
34027271-5	2021	We studied the changes in the PRMT1-dependent arginine methylated proteome after alcohol feeding in mouse liver using mass spectrometry.	Arginine	46-54	protein arginine N-methyltransferase 1	Mus musculus	30-35
34027271-6	2021	We found that arginine methylation of the RNA-binding protein (heterogeneous nuclear ribonucleoprotein [hnRNP]) H1 is mediated by PRMT1 and is altered in alcohol-fed mice.	Arginine	14-22	protein arginine N-methyltransferase 1	Mus musculus	130-135
26997641-1	2016	BACKGROUND: Recently, antibodies directed against peptidyl arginine deiminase 3 and 4 (anti-PAD3/PAD4 antibodies), calcium-dependent enzymes that catalyze the conversion from arginine to citrulline, have been described.	Arginine	59-67	peptidyl arginine deiminase 4	Homo sapiens	97-101
33575089-4	2021	Correlation analysis between significant differential metabolites and proteins revealed seven proteins and ten metabolites, of which metabolite L-Arg was negatively correlated with P4HA1 protein.	Arginine	144-149	prolyl 4-hydroxylase subunit alpha 1	Homo sapiens	181-186
33428336-1	2021	Recurrent glycine-to-arginine/valine alterations at codon 34 (G34R/V) within H3F3A gene characterize a subset of hemispheric high-grade gliomas (HGG) affecting children and young adults.	Arginine	21-29	H3.3 histone A	Homo sapiens	77-82
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Arginine	28-36	alanyl (membrane) aminopeptidase	Mus musculus	83-87
26768609-2	2016	The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells.	Arginine	28-36	alanyl (membrane) aminopeptidase	Mus musculus	89-105
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Arginine	80-83	glutathione S-transferase pi 1	Homo sapiens	173-178
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	TNF receptor superfamily member 10b	Homo sapiens	67-70
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	TNF receptor superfamily member 10b	Homo sapiens	107-110
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	Fas associated via death domain	Homo sapiens	126-130
33440291-5	2021	D-arginine, a metabolically inert enantiomer of L-arginine, could produce nitric oxide and down-regulate hypoxia-inducible factor-1alpha (HIF-1alpha) to alleviate tumor hypoxia.	Arginine	48-58	hypoxia inducible factor 1, alpha subunit	Mus musculus	105-136
27129269-8	2016	The residues of Trp-354, Arg-359, Glu-355, Leu-363, and Glu-367 in DR5 death domain that are important for DR5 recruitment of FADD and caspase-8 for DISC formation to signal apoptosis also play an important role for CaM-DR5 binding.	Arginine	25-28	TNF receptor superfamily member 10b	Homo sapiens	107-110
33440291-5	2021	D-arginine, a metabolically inert enantiomer of L-arginine, could produce nitric oxide and down-regulate hypoxia-inducible factor-1alpha (HIF-1alpha) to alleviate tumor hypoxia.	Arginine	48-58	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-148
33634976-12	2021	In mice, MFG-E8 administration decreased L-arginine-induced pancreatic injury and mortality.	Arginine	41-51	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	9-15
27275094-1	2016	AIM: To investigate the potential protective effect of exogenous recombinant interleukin-22 (rIL-22) on L-arginine-induced acute severe pancreatitis (SAP)-associated lung injury and the possible signaling pathway involved.	Arginine	104-114	interleukin 22	Mus musculus	77-91
27275094-16	2016	CONCLUSION: Exogenous recombinant IL-22 protects mice against L-arginine-induced SAP-associated lung injury by enhancing the expression of anti-apoptosis genes through the STAT3 signaling pathway.	Arginine	62-72	interleukin 22	Mus musculus	34-39
33634976-14	2021	MFG-E8 knockout mice suffered more severe pancreatic injury and greater mitochondrial damage after l-arginine administration.	Arginine	99-109	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	0-6
33747724-4	2021	Mechanistically, PADI2 interacting and catalyzing MEK1 citrullination at arginine 113/189 facilitates MEK1 on extracellular signal-regulated protein kinases 1/2 (ERK1/2) phosphorylation, which activates insulin-like growth factor-II binding protein 1 (IGF2BP1) expression.	Arginine	73-81	mitogen-activated protein kinase kinase 1	Homo sapiens	50-54
26947510-2	2016	Recently, Berendse et al reported an improvement of peroxisomal functions with l-arginine supplementation in fibroblasts with specific mutations of PEX1, PEX6, and PEX12.	Arginine	79-89	peroxisomal biogenesis factor 12	Homo sapiens	164-169
26947510-3	2016	We report the first treatment by l-arginine in a patient homozygous for the specific PEX12 mutation shown to be l-arginine responsive in fibroblasts.	Arginine	33-43	peroxisomal biogenesis factor 12	Homo sapiens	85-90
26947510-3	2016	We report the first treatment by l-arginine in a patient homozygous for the specific PEX12 mutation shown to be l-arginine responsive in fibroblasts.	Arginine	112-122	peroxisomal biogenesis factor 12	Homo sapiens	85-90
33747724-4	2021	Mechanistically, PADI2 interacting and catalyzing MEK1 citrullination at arginine 113/189 facilitates MEK1 on extracellular signal-regulated protein kinases 1/2 (ERK1/2) phosphorylation, which activates insulin-like growth factor-II binding protein 1 (IGF2BP1) expression.	Arginine	73-81	mitogen-activated protein kinase kinase 1	Homo sapiens	102-106
33478587-0	2021	Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells.	Arginine	14-22	argininosuccinate synthase 1	Homo sapiens	123-127
27033700-7	2016	The NTIMP2 mutant, S2D/S4A is a selective MMP1 inhibitor through electrostatic effects of a unique MMP-1 arginine.	Arginine	105-113	matrix metallopeptidase 1	Homo sapiens	42-46
27033700-7	2016	The NTIMP2 mutant, S2D/S4A is a selective MMP1 inhibitor through electrostatic effects of a unique MMP-1 arginine.	Arginine	105-113	matrix metallopeptidase 1	Homo sapiens	99-104
33478587-0	2021	Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells.	Arginine	76-84	argininosuccinate synthase 1	Homo sapiens	123-127
27142074-2	2016	In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprotective potency increases with polymer length plateauing at R15 to R18 (R = arginine resides).	Arginine	175-183	ribonuclease A family member 2	Rattus norvegicus	159-162
33478587-1	2021	BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle.	Arginine	122-130	argininosuccinate synthase 1	Homo sapiens	54-84
33478587-1	2021	BACKGROUND: Many cancers silence the metabolic enzyme argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis within the urea cycle.	Arginine	122-130	argininosuccinate synthase 1	Homo sapiens	86-90
26767372-6	2016	Using the novel bioluminescent binding assay, we demonstrated that three highly conserved B-chain Arg residues of relaxin-3 had distinct contributions to binding of the receptor RXFP1.	Arginine	98-101	relaxin 3	Homo sapiens	114-123
33478587-2	2021	Consequently, ASS1-negative cells are susceptible to depletion of extracellular arginine by PEGylated arginine deiminase (ADI-PEG20), an agent currently being developed in clinical trials.	Arginine	80-88	argininosuccinate synthase 1	Homo sapiens	14-18
26767372-6	2016	Using the novel bioluminescent binding assay, we demonstrated that three highly conserved B-chain Arg residues of relaxin-3 had distinct contributions to binding of the receptor RXFP1.	Arginine	98-101	relaxin family peptide receptor 1	Homo sapiens	178-183
33478587-3	2021	As the primary mechanism of resistance to arginine depletion is re-expression of ASS1, we sought a tool to understand the temporal emergence of the resistance phenotype at the single-cell level.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	81-85
33478587-6	2021	RESULTS: Every ASS1-deficient cell analyzed was found to respond to arginine deprivation by decreased expression of the sensor, indicating an absence of resistance in the naive cell population.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	15-19
33479198-3	2021	Here we demonstrate that the N protein"s central disordered domain drives phase separation with RNA, and that phosphorylation of an adjacent serine/arginine rich region modulates the physical properties of the resulting condensates.	Arginine	148-156	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	29-30
26972470-2	2016	The protein contains a functional PDZ domain that has been solved in complex with a phage display-derived heptapeptide: Asp-6 Ser-5 Arg-4 Ile-3 Trp-2 Trp-1 Val0 .	Arginine	132-135	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	150-155
26983598-6	2016	Western blotting and enzymatic activity assays validated that the key enzymes ADH1C, ALDH1A1, and ALDH2, which are mainly involved in ethanol degradation pathways, were highly differentially expressed, and activated between Ctrl and +Arg in HepG2 cells.	Arginine	234-237	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	78-83
33249073-4	2021	Citrullination is a post-translational modification that involves conversion of peptidyl-based arginine to peptidyl-based citrulline by PAD family members in a calcium-dependent manner.	Arginine	95-103	peptidyl arginine deiminase 4	Homo sapiens	136-139
33290556-6	2021	By exchanging arginine to a lysine, the corresponding side chain in DNMT3B, the sequence preference is reversed, confirming the requirement for arginine at this position.	Arginine	14-22	DNA methyltransferase 3 beta	Homo sapiens	68-74
26983598-6	2016	Western blotting and enzymatic activity assays validated that the key enzymes ADH1C, ALDH1A1, and ALDH2, which are mainly involved in ethanol degradation pathways, were highly differentially expressed, and activated between Ctrl and +Arg in HepG2 cells.	Arginine	234-237	aldehyde dehydrogenase 1 family member A1	Homo sapiens	85-92
33290556-6	2021	By exchanging arginine to a lysine, the corresponding side chain in DNMT3B, the sequence preference is reversed, confirming the requirement for arginine at this position.	Arginine	144-152	DNA methyltransferase 3 beta	Homo sapiens	68-74
26947067-4	2016	Mice with the arginine 72 (R72) variant of p53 developed more-severe obesity and glucose intolerance on a HFD, compared to mice with the proline 72 variant (P72).	Arginine	14-22	transformation related protein 53, pseudogene	Mus musculus	43-46
33593046-1	2021	Peptidyl arginine deiminase 4 (PADI4), an enzyme that converts arginine residues to citrulline residues in the presence of calcium ions, affects the biochemical activities of proteins.	Arginine	9-17	peptidyl arginine deiminase 4	Homo sapiens	31-36
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	vascular endothelial growth factor A	Rattus norvegicus	172-176
26824643-0	2016	Mimicking of Arginine by Functionalized N(omega)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.	Arginine	13-21	neuropeptide Y	Homo sapiens	167-181
26824643-0	2016	Mimicking of Arginine by Functionalized N(omega)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.	Arginine	63-71	neuropeptide Y	Homo sapiens	167-181
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	vascular endothelial growth factor A	Rattus norvegicus	172-176
33291128-1	2020	The metabolic enzyme-based arginine deprivation represents a tremendous opportunity to treat argininosuccinate synthetase (ASS1)-deficient tumors.	Arginine	27-35	argininosuccinate synthetase 1	Mus musculus	123-127
26851535-1	2016	Spiro sugar-isoxazolidines obtained by 1,3-dipolar cycloaddition of activated exo-glycals and nitrones were efficiently functionalized at two sites, i.e. C-4 and C-7, with arginine, arginine mimetics and guanidylated appendages.	Arginine	172-180	complement C4A (Rodgers blood group)	Homo sapiens	154-157
26851535-1	2016	Spiro sugar-isoxazolidines obtained by 1,3-dipolar cycloaddition of activated exo-glycals and nitrones were efficiently functionalized at two sites, i.e. C-4 and C-7, with arginine, arginine mimetics and guanidylated appendages.	Arginine	182-190	complement C4A (Rodgers blood group)	Homo sapiens	154-157
33008598-3	2020	Prmt7 is the only family member responsible for mono-methylation of arginine residue.	Arginine	68-76	protein arginine N-methyltransferase 7	Mus musculus	0-5
26678503-2	2016	This molecule results from the decarboxylation of L-arginine by arginine decarboxylase, and it is hydrolyzed to urea and putrescine by agmatinase.	Arginine	50-60	agmatinase	Rattus norvegicus	135-145
33296397-7	2020	Further, the presence of an arginine cluster in the extended signal peptides of other proteins (E3 ubiquitin-protein ligase, NOTCH3) is noted and indicates a more general importance of this cis-acting mechanism of translational suppression.	Arginine	28-36	notch receptor 3	Homo sapiens	125-131
33302555-3	2020	In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y+L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing.	Arginine	264-274	solute carrier family 7 member 7	Homo sapiens	142-148
26683606-4	2016	Moreover, rReg3alpha administration significantly reduced the pancreatic damage caused by L-Arg injection, as shown in histological examination and serum amylase, lipase and C-reactive protein (CRP) assays.	Arginine	90-95	regenerating islet-derived 3 alpha	Rattus norvegicus	10-20
26797521-2	2016	Although another plasma serpin with an Arg-Ser reactive centre, antithrombin (AT), has been shown to inhibit factor VIIa (FVIIa), no published data are available with respect to FVIIa inhibition by API M358R.	Arginine	39-42	serpin family C member 1	Homo sapiens	64-76
32912862-4	2020	One of the latter (rs13266634) locates in a SLC30A8 exon, encoding a tryptophan-to-arginine substitution that decreases SLC30A8 function, being the canonical explanation for type 2 diabetes risk association.	Arginine	83-91	solute carrier family 30 (zinc transporter), member 8	Danio rerio	44-51
26802462-0	2016	L-Arginine ethylester enhances in vitro amplification of PrP(Sc) in macaques with atypical L-type bovine spongiform encephalopathy and enables presymptomatic detection of PrP(Sc) in the bodily fluids.	Arginine	0-10	PRP@	Bos taurus	57-60
26802462-0	2016	L-Arginine ethylester enhances in vitro amplification of PrP(Sc) in macaques with atypical L-type bovine spongiform encephalopathy and enables presymptomatic detection of PrP(Sc) in the bodily fluids.	Arginine	0-10	PRP@	Bos taurus	171-174
26802462-2	2016	We developed an effective amplification method for PrP(Sc) derived from macaques infected with the atypical L-type bovine spongiform encephalopathy (L-BSE) prion by using mouse brain homogenate as a substrate in the presence of polyanions and L-arginine ethylester.	Arginine	243-253	PRP@	Bos taurus	51-54
32912862-4	2020	One of the latter (rs13266634) locates in a SLC30A8 exon, encoding a tryptophan-to-arginine substitution that decreases SLC30A8 function, being the canonical explanation for type 2 diabetes risk association.	Arginine	83-91	solute carrier family 30 (zinc transporter), member 8	Danio rerio	120-127
33135249-3	2020	The ISD spectra of peptides containing an arginine (Arg) residue at carboxyl (C)-termini showed preferential [w]+ ions when 4-nitro-1-naphthol (4,1-NNL) matrix was used, whereas the use of 3,5-dinitrosalicylic acid (3,5-DNSA) resulted in preferential [x]+ ions.	Arginine	42-50	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	52-55
26572832-10	2016	CONCLUSIONS: In codon 634, arginine substitutions for cysteine may cause slightly higher penetrance rates of MEN 2A which, overall, are too small to treat carriers differently.	Arginine	27-35	ret proto-oncogene	Homo sapiens	109-115
26572822-4	2016	Analysis of the putative arginine-methylated proteins revealed that they were predominantly nuclear or nucleolar in localization, consistent with the localization of Hmt1.	Arginine	25-33	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	166-170
33051382-5	2020	Following the suppression of ASS1 protein levels, miR-1291 perturbed arginine homeostasis and preferably sensitized ASS1-abundant L3.3 cells to arginine deprivation therapy.	Arginine	144-152	argininosuccinate synthase 1	Homo sapiens	116-120
33051382-8	2020	Our results demonstrated that miR-1291 was effective to sensitize PC cells to arginine deprivation treatment and chemotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glycolysis, respectively, which may provide insights into understanding miRNA signaling underlying cancer cell metabolism and development of new strategies for the treatment of lethal PC.	Arginine	78-86	argininosuccinate synthase 1	Homo sapiens	144-148
33248609-6	2020	The relative expression of IL-1beta, myeloid differentiation primary response 88, and Toll-like receptor 4 decreased linearly (P < 0.05) in the ileum with increasing dietary Arg levels; secretory IgA contents were increased.	Arginine	174-177	interleukin 1, beta	Gallus gallus	27-35
33248609-6	2020	The relative expression of IL-1beta, myeloid differentiation primary response 88, and Toll-like receptor 4 decreased linearly (P < 0.05) in the ileum with increasing dietary Arg levels; secretory IgA contents were increased.	Arginine	174-177	myeloid differentiation primary response 88	Gallus gallus	37-80
33248609-6	2020	The relative expression of IL-1beta, myeloid differentiation primary response 88, and Toll-like receptor 4 decreased linearly (P < 0.05) in the ileum with increasing dietary Arg levels; secretory IgA contents were increased.	Arginine	174-177	toll like receptor 4	Gallus gallus	86-106
26811329-6	2016	More interestingly, GGA3 physically interacted with alpha2B-AR, and the interaction sites were identified as the triple Arg motif in the third intracellular loop of the receptor and the acidic motif EDWE in the VHS domain of GGA3.	Arginine	120-123	adrenoceptor alpha 2B	Homo sapiens	52-62
32615218-7	2020	We also found that FKBP39 can lead to LLPS in the presence of RNA and peptides containing Arg-rich linear motifs derived from selected nuclear and nucleolar proteins.	Arginine	90-93	FK506-binding protein 39kD	Drosophila melanogaster	19-25
26555266-5	2016	Using a highly sensitive solution fluorescence assay, we have examined binding of CR456 to arginine and lysine variants of PAI-1 and definitively identified the binding site as composed of four basic residues, Lys-69, Arg-76, Lys-80, and Lys-88.	Arginine	218-221	serpin family E member 1	Homo sapiens	123-128
33343341-10	2020	Additionally, wortmannin and Akt inhibitor VIII blocked the protective effect of gastrin on viability of HK-2 cells subjected to H/R treatment.	Arginine	131-132	gastrin	Homo sapiens	81-88
26321390-5	2016	This altered antitumor immunity is due in part to the expansion of myeloid-derived suppressor cells (MDSC), which are characterized by an ability to suppress the antitumor activity of T-cells by down-regulation of the T-cell receptor zeta chain (TCRzeta) through the catabolism of L-arginine.	Arginine	281-291	CD247 molecule	Homo sapiens	218-244
26321390-5	2016	This altered antitumor immunity is due in part to the expansion of myeloid-derived suppressor cells (MDSC), which are characterized by an ability to suppress the antitumor activity of T-cells by down-regulation of the T-cell receptor zeta chain (TCRzeta) through the catabolism of L-arginine.	Arginine	281-291	CD247 molecule	Homo sapiens	246-253
33395072-5	2020	Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy.	Arginine	110-118	argininosuccinate synthase 1	Homo sapiens	51-55
26763290-2	2016	Sepiapterin (SEP) is a tetrahydrobiopterin precursor, and L-citrulline (L-Cit) is converted to endothelial nitric oxide synthase substrate, L-arginine.	Arginine	140-150	nitric oxide synthase 3, endothelial cell	Mus musculus	95-128
27306203-3	2016	Exome sequencing revealed a homozygous SLC25A1 missense mutation [NM_005984.4: c.593G&gt;A; p.(Arg198His)] of a ubiquitously conserved arginine residue putatively situated within the substrate-binding site I of CIC.	Arginine	135-143	solute carrier family 25 member 1	Homo sapiens	39-46
26394130-7	2015	One arginine recycling enzyme - argininosuccinate synthase (ASS1) - was further confirmed to be significantly downregulated in the urine of 30 depressed subjects while remaining unchanged in the plasma.	Arginine	4-12	argininosuccinate synthase 1	Homo sapiens	32-58
26394130-7	2015	One arginine recycling enzyme - argininosuccinate synthase (ASS1) - was further confirmed to be significantly downregulated in the urine of 30 depressed subjects while remaining unchanged in the plasma.	Arginine	4-12	argininosuccinate synthase 1	Homo sapiens	60-64
33395072-6	2020	However, drug resistance develops during arginine depletion treatment, along with the re-expression of ASS1, metabolic dysfunction, and the appearance of anti-drug antibody.	Arginine	41-49	argininosuccinate synthase 1	Homo sapiens	103-107
33097830-8	2020	Our findings highlight an important role for CD90+ stromal cells in L-arginine-stimulated ISC expansion.	Arginine	68-78	Thy-1 cell surface antigen	Homo sapiens	45-49
32913000-4	2020	The structure reveals that cGAS employs two conserved arginines to anchor to the nucleosome acidic patch.	Arginine	54-63	cyclic GMP-AMP synthase	Homo sapiens	27-31
26363782-8	2015	In the second region, a SNP was detected in exon 11 of the Vwa2 gene with an exchange from arginine to tryptophan.	Arginine	91-99	von Willebrand factor A domain containing 2	Rattus norvegicus	59-63
32800549-6	2020	First, we found that the ubiquitination activity of Rsp5 was essential for the arginine-induced endocytosis of Put4.	Arginine	79-87	NEDD4 family E3 ubiquitin-protein ligase	Saccharomyces cerevisiae S288C	52-56
32999062-4	2020	Lesion bypass is accomplished using a unique protein-template mechanism in which the templating base is evicted from the DNA helix and the incoming dCTP hydrogen bonds with an arginine side chain of Rev1.	Arginine	176-184	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	199-203
26349791-11	2015	l-Arginine 100mg/kg+theophylline 20mg/kg suppressed TNF-alpha and elevates IL-10 level as well as reversed adjuvant-induced elevated arthritic parameters as compared to only adjuvant and prednisone group (p&lt;0.001).	Arginine	0-10	interleukin 10	Rattus norvegicus	75-80
26577684-5	2015	In an in vivo model of stimulated peritoneal macrophages, IP administration of HA-PEI/pDNA-IL4 and HA-PEI/pDNA-IL10 to C57BL/6 mice significantly increased the Arg/iNOS ratio and CD163 expression in the cells.	Arginine	160-163	interleukin 4	Mus musculus	91-94
32806354-6	2020	The ermB gene concentration was significantly correlated (p < 0.05) with E. coli and Enterococcus concentrations in 2017, suggesting a potential use of this ARG as an indicator of environmental AMR and human health risk.	Arginine	157-160	rRNA adenine N-6-methyltransferase	Escherichia coli	4-8
26348775-10	2015	Among theses factors, Calnexin (CNX) was the only one factor, which belonged to both groups, suggesting that CNX might play a key role in arginine-induced insulin secretion in ER.	Arginine	138-146	calnexin	Mus musculus	22-30
26348775-10	2015	Among theses factors, Calnexin (CNX) was the only one factor, which belonged to both groups, suggesting that CNX might play a key role in arginine-induced insulin secretion in ER.	Arginine	138-146	calnexin	Mus musculus	32-35
26348775-10	2015	Among theses factors, Calnexin (CNX) was the only one factor, which belonged to both groups, suggesting that CNX might play a key role in arginine-induced insulin secretion in ER.	Arginine	138-146	calnexin	Mus musculus	109-112
32556547-7	2020	We also report that the arginine residue present at the 95th position in the C-terminal tail of histone H4 protein is required for complementation of the MMS resistance in the Cghhf1Deltahhf2Delta mutant, thereby pointing out a probable role of this residue in association with HR factors.	Arginine	24-32	H4 clustered histone 6	Homo sapiens	96-106
32844405-3	2020	This study, by employing function and computation methods, proposes that charged residues (including the Arg residue) at the pore extracellular half from each of the five subunits of the homomeric alpha1 GlyR, create an electrostatic repulsive potential to widen the pore, thereby facilitating channel opening.	Arginine	105-108	glycine receptor alpha 1	Homo sapiens	197-208
26463496-7	2015	Molecular dynamics simulations of H180R and G304R HDAC8 mutants suggest that the bulky arginine side chain of each mutant protrudes into the substrate binding site and also causes active site residue Y306 to fluctuate away from the position required for substrate activation and catalysis.	Arginine	87-95	histone deacetylase 8	Homo sapiens	50-55
32844405-11	2020	Accordingly, it was hypothesized that the placed Arg residues from each of the five subunits of the homomeric alpha1 GlyR create an electrostatic repulsive potential to widen the pore, thereby facilitating channel opening.	Arginine	49-52	glycine receptor alpha 1	Homo sapiens	110-121
32828270-5	2020	Kn2-7 enhanced the cellular uptake of CpG DNA; this effect was decreased by the substitution of arginine residues with alanine residues, and increased by the substitution of lysine residues with arginine residues.	Arginine	96-104	immunoglobulin kappa chain variable 4-70	Mus musculus	0-5
25927599-9	2015	INNOVATION: These findings showed for the first time that arginine 213 in the HBD of SOD3 is critical for maintaining proper organ function through moderating the normal innate immune response, which would otherwise lead to chronic inflammation and degenerative diseases in aged mice.	Arginine	58-66	superoxide dismutase 3, extracellular	Mus musculus	85-89
32828270-5	2020	Kn2-7 enhanced the cellular uptake of CpG DNA; this effect was decreased by the substitution of arginine residues with alanine residues, and increased by the substitution of lysine residues with arginine residues.	Arginine	195-203	immunoglobulin kappa chain variable 4-70	Mus musculus	0-5
26869868-13	2015	L-arginine supplementation causes additional effects on exercise-induced angiogenesis by preventing more reduction of VEGF gene expression in response to exercise.	Arginine	0-10	vascular endothelial growth factor A	Rattus norvegicus	118-122
33013381-17	2020	These results suggested that Ginsenoside Re treatment attenuated the myocardial injury induced by H/R, and the possible mechanism was associated with the inhibition of HIF-1alpha ubiquitination.	Arginine	41-42	hypoxia inducible factor 1, alpha subunit	Mus musculus	168-178
26122358-2	2015	Myeloid-derived suppressor cells (MDSCs) down-regulate the T cell receptor zeta chain (TCR zeta) through L-arginine deprivation and lead to T cell dysfunction and deficient antitumor immunity.	Arginine	105-115	CD247 molecule	Homo sapiens	59-85
26122358-2	2015	Myeloid-derived suppressor cells (MDSCs) down-regulate the T cell receptor zeta chain (TCR zeta) through L-arginine deprivation and lead to T cell dysfunction and deficient antitumor immunity.	Arginine	105-115	CD247 molecule	Homo sapiens	87-95
32255561-6	2020	RESULTS: Autocitrullination of PAD2 and PAD4 was detected in 16 (48%) of 33 arginine residues and 7 (26%) of 27 arginine residues, respectively.	Arginine	76-84	peptidyl arginine deiminase 4	Homo sapiens	40-44
26214584-5	2015	Our results clearly demonstrated that diet supplementation with l-arginine, sepiapterin along with salsalate improved phosphorylation of eNOS and enhanced vasorelaxation of thoracic/abdominal aorta in type-1 diabetic mice.	Arginine	64-74	nitric oxide synthase 3, endothelial cell	Mus musculus	137-141
32255561-6	2020	RESULTS: Autocitrullination of PAD2 and PAD4 was detected in 16 (48%) of 33 arginine residues and 7 (26%) of 27 arginine residues, respectively.	Arginine	112-120	peptidyl arginine deiminase 4	Homo sapiens	40-44
32592929-4	2020	We also examined the expressions and locations of various Lm-PHB2 deletion mutants and the amino acid mutant by confocal microscopy and the results showed that the translocation of Lm-PHB2 into mitochondria was dependent on the Lm-PHB21-50aa region and the 17th, 48th and 57th three arginines (R) of N-terminal were very critical.	Arginine	283-292	prohibitin 2	Homo sapiens	181-188
26189065-0	2015	Cell- and nuclear-penetrating anti-dsDNA autoantibodies have multiple arginines in CDR3 of VH and increase cellular level of pERK and Bcl-2 in mesangial cells.	Arginine	70-79	cerebellar degeneration-related 3	Mus musculus	83-87
26189065-2	2015	The present study reports that three anti-dsDNA monoclonal autoAbs, which contain more than two arginine residues in their CDR3s of variable heavy domain (VH), penetrated into living murine mesangial cells and the cell nuclei.	Arginine	96-104	cerebellar degeneration-related 3	Mus musculus	123-127
26189065-5	2015	The scFv and VH domain, containing arginine in CDR3-VH maintained the ability to penetrate cells and the cell nuclei, whereas the VL domain, having no arginine in CDR3, did not penetrate cells.	Arginine	35-43	cerebellar degeneration-related 3	Mus musculus	47-51
26189065-8	2015	The data indicate that an antigen-binding site is required for cell-penetration and that positively-charged arginine residues in CDR3-VH contribute to the cell- and nuclear-penetrating ability of a subset of anti-dsDNA autoAbs.	Arginine	108-116	cerebellar degeneration-related 3	Mus musculus	129-133
32430362-4	2020	This hairpin (HP1), comprising the signature sequence of the 7SKsnRNA, has been the subject of three independent structural studies aiming at identifying the structural features that could drive the recognition by the two proteins, both depending on Arginine Rich Motifs (ARM).	Arginine	250-258	chromobox 5	Homo sapiens	14-17
26210451-1	2015	The enzymatic biosynthesis of L-arginine involves complex, sequential action of many enzymes and ornithine transcarbamylase (OTCase) is one of the essential enzymes in the pathway.	Arginine	30-40	ornithine transcarbamylase	Homo sapiens	125-131
32839531-8	2020	Furthermore, the expression of mRNAs participating in arginine biosynthesis (CPS1, OTC, Arg1) and do novo purine synthesis (GART, PAICS, ATIC) were validated through RT-qPCR.	Arginine	54-62	ornithine transcarbamylase	Homo sapiens	83-86
32815043-3	2020	This is in contrast to the capability of CatG acting in a proteolytic-independent manner due to the net charge of arginine residues in the CatG sequence which interferes with bacteria.	Arginine	114-122	cathepsin G	Homo sapiens	41-45
26199422-6	2015	Arg(302) is a crucial contact to enable vaspin recognition by KLK7 and it supports moderate inhibition of the serpin despite the presence of the detrimental P1" Glu(379), which clearly represents a major limiting factor for vaspin-inhibitory activity.	Arginine	0-3	kallikrein related peptidase 7	Homo sapiens	62-66
26085164-6	2015	In contrast, mutation of K42 to arginine did not cause any loss of function, suggesting that the interaction with gp120 is primarily electrostatic in nature.	Arginine	32-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	114-119
26179907-0	2015	Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription.	Arginine	8-16	protein arginine N-methyltransferase 7	Mus musculus	32-37
26179907-5	2015	To explore the effects of aberrant histone arginine methylation on B cells, we generated mice with a B cell-specific knockout of PRMT7, a member of the methyltransferases that mediate arginine methylation of histones.	Arginine	184-192	protein arginine N-methyltransferase 7	Mus musculus	129-134
25728989-5	2015	As a proof-of-concept, the integrin-binding tripeptide Arg-Gly-Asp (RGD) sequence from fibronectin was integrated into mouse amelogenin (rM179) at three different positions.	Arginine	55-58	fibronectin 1	Mus musculus	87-98
32815043-3	2020	This is in contrast to the capability of CatG acting in a proteolytic-independent manner due to the net charge of arginine residues in the CatG sequence which interferes with bacteria.	Arginine	114-122	cathepsin G	Homo sapiens	139-143
32817790-6	2020	These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis (sterol regulatory element-binding protein-1, acetyl-CoA carboxylase alpha, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid beta-oxidation (carnitine palmitoyltransferase 1alpha and peroxisome proliferator-activated receptor alpha).	Arginine	17-25	acyl-CoA desaturase	Oreochromis niloticus	182-205
32783662-4	2020	In addition, L-arginine injections significantly (p < .0001) increased the expression of TNF-alpha mRNA and protein, and decreased phospho-AMPK and IL-10 mRNA and protein that was significantly (p < .0001) protected by vitamin E.	Arginine	13-23	interleukin 10	Rattus norvegicus	148-153
32783662-5	2020	Furthermore, vitamin E inhibited L-arginine-induced blood levels of LDH, amylase, and myeloperoxidase.	Arginine	33-43	myeloperoxidase	Rattus norvegicus	86-101
32692156-0	2020	The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.	Arginine	64-67	activating transcription factor 3	Homo sapiens	4-8
32692156-8	2020	We also show, through chase-degradation assays with [UBR1-/- UBR2-/-] and wild-type human cells, that the Arg/N-degron pathway mediates a large fraction of ATF3 degradation.	Arginine	106-109	activating transcription factor 3	Homo sapiens	156-160
32692156-11	2020	These and other binding patterns, whose mechanics remain to be understood, may signify a conditional (regulated) degradation of ATF3 by the Arg/N-degron pathway.	Arginine	140-143	activating transcription factor 3	Homo sapiens	128-132
32689592-6	2020	RESULTS: In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively).	Arginine	98-108	ficolin 3	Homo sapiens	41-50
32689592-6	2020	RESULTS: In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively).	Arginine	98-108	MBL associated serine protease 1	Homo sapiens	52-57
32689592-6	2020	RESULTS: In the hyperacute stage of AIS, ficolin-3, MAP-1 and MBL were positively correlated with L-arginine within 6 h after onset of symptoms (p<0.05 respectively).	Arginine	98-108	mannose binding lectin 2	Homo sapiens	62-65
32703948-8	2020	Together, these results suggest that ZIP may act as an arginine donor, facilitating NO-dependent downregulation of AMPARs, thereby attenuating learning and memory.	Arginine	55-63	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	115-121
32650547-0	2020	Phosphorylation of the Arginine-Rich C-Terminal Domains of the Hepatitis B Virus (HBV) Core Protein as a Fine Regulator of the Interaction between HBc and Nucleic Acid.	Arginine	23-31	keratin 88, pseudogene	Homo sapiens	147-150
32711437-12	2020	Significant increased risk of lung cancer was found with Arg/Pro genotypes of TP53, Lys/Gln and Gln/Gln variants of XPD in individuals with family history of cancer (OR=3.44; 95% CI=1.36-8.72; p=0.011; OR=3.17; 95% CI=1.20-8.39; p=0.024; OR=16.35; 95% CI=0.92-289.5; p=0.007, respectively).	Arginine	57-60	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	116-119
32681621-8	2020	Similarly, PLOD3 gene shows missense mutation in heterozygous condition due to loss of guanine in the sequence AGG A-G and it is responsible for the change in post-translational event of amino acid where arginine change into lysine.	Arginine	204-212	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	Homo sapiens	11-16
32570260-1	2021	Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity and lordosis behavior.	Arginine	122-130	G protein-coupled estrogen receptor 1	Rattus norvegicus	37-74
32570260-1	2021	Introduction The membrane-associated G protein-coupled estrogen receptor 1 (GPER) mediates the regulation by estradiol on arginine-vasopressin immunoreactivity in the supraoptic and paraventricular hypothalamic nuclei of female rats and is involved in the estrogenic control of hypothalamic regulated functions, such as food intake, sexual receptivity and lordosis behavior.	Arginine	122-130	G protein-coupled estrogen receptor 1	Rattus norvegicus	76-80
32637492-3	2020	We employed Synthetic Dosage Lethality (SDL) screening in Saccharomyces cerevisiae, for the identification of putative regulators of arginine methylation mediated by Hmt1 (HnRNP methyltransferase 1), ortholog of human PRMT1.	Arginine	133-141	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	166-170
32637492-3	2020	We employed Synthetic Dosage Lethality (SDL) screening in Saccharomyces cerevisiae, for the identification of putative regulators of arginine methylation mediated by Hmt1 (HnRNP methyltransferase 1), ortholog of human PRMT1.	Arginine	133-141	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	172-197
32637492-9	2020	This dataset can be further exploited in biochemical and functional studies to illuminate which of the SDL interactors of Hmt1 correspond to factors implicated in the regulation of Hmt1-mediated arginine methylation and reveal the underlying molecular mechanisms.	Arginine	195-203	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	122-126
32637492-9	2020	This dataset can be further exploited in biochemical and functional studies to illuminate which of the SDL interactors of Hmt1 correspond to factors implicated in the regulation of Hmt1-mediated arginine methylation and reveal the underlying molecular mechanisms.	Arginine	195-203	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	181-185
32538685-5	2022	(Pro to Arg substitution) at 252 of the exon 8 of the FGFR2 encoding for Apert syndrome.	Arginine	8-11	fibroblast growth factor receptor 2	Homo sapiens	54-59
32543462-10	2020	However, heterozygote genotypes (Gln-Arg and Ile-Val) in XRCC1 and GSTP1 genes, respectively, were associated with LINE-1 hypermethylation among UE compared with other corresponding genotypes.	Arginine	37-40	glutathione S-transferase pi 1	Homo sapiens	67-72
32454788-0	2020	Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis.	Arginine	12-20	NLR family, pyrin domain containing 3	Mus musculus	50-55
32454788-4	2020	This study investigated the effect of intravenous Arg supplementation on modulating NLRP3 inflammasome activity in relation to septic AKI.	Arginine	50-53	NLR family, pyrin domain containing 3	Mus musculus	84-89
32454788-12	2020	After Arg treatment, plasma Arg and NO levels increased, kidney function improved, and expressions of renal NLRP3 inflammasome-related proteins were downregulated.	Arginine	6-9	NLR family, pyrin domain containing 3	Mus musculus	108-113
32454788-13	2020	Changes in plasma NO and renal NLRP3 inflammasome-related protein expression were abrogated when L-NIL was given to the Arg sepsis groups.	Arginine	120-123	NLR family, pyrin domain containing 3	Mus musculus	31-36
32454788-15	2020	The findings suggest that intravenous Arg supplementation immediately after sepsis restores plasma Arg levels and is beneficial for attenuating septic AKI, partly via NO-mediated NLRP3 inflammasome inhibition.	Arginine	38-41	NLR family, pyrin domain containing 3	Mus musculus	179-184
32062385-8	2020	RESULTS: At 72 h after the induction of AP with l-arginine, significantly lower levels of serum amylase, lipase, TNF-alpha, and IL-1beta were observed in KO mice when compared with WT controls.	Arginine	48-58	lipase, endothelial	Mus musculus	105-111
32062385-8	2020	RESULTS: At 72 h after the induction of AP with l-arginine, significantly lower levels of serum amylase, lipase, TNF-alpha, and IL-1beta were observed in KO mice when compared with WT controls.	Arginine	48-58	interleukin 1 alpha	Mus musculus	128-136
32234784-4	2020	Our biophysical investigations show that TNPO1 recognizes an arginine-glycine(-glycine) (RG/RGG)-rich region, whereas TNPO3 recognizes a region rich in arginine-serine-tyrosine (RSY) residues.	Arginine	61-69	transportin 1	Homo sapiens	41-46
26171055-9	2015	The epidermal growth factor (EGF)-induced proliferation of AGS cells was inhibited by infection with Ad-PKG II and treatment with SNP or L-arginine.	Arginine	137-147	epidermal growth factor	Homo sapiens	4-27
32322336-4	2020	Methods: Mouse models of AP were established by caerulein, sodium taurocholate, and L-arginine, separately.	Arginine	84-94	LIM homeobox protein 2	Mus musculus	25-27
26171055-9	2015	The epidermal growth factor (EGF)-induced proliferation of AGS cells was inhibited by infection with Ad-PKG II and treatment with SNP or L-arginine.	Arginine	137-147	epidermal growth factor	Homo sapiens	29-32
25918018-0	2015	A lysine-to-arginine mutation on NEDD8 markedly reduces the activity of cullin RING E3 ligase through the impairment of neddylation cascades.	Arginine	12-20	CDK2 associated cullin domain 1	Homo sapiens	72-78
26068232-4	2015	A bifunctional enzyme was identified in certain bacteria, which catalyzes both NAGS and N-acetylglutamate kinase (NAGK) activities, the first two steps of the arginine biosynthetic pathway.	Arginine	159-167	N-acetylglucosamine kinase	Homo sapiens	88-112
26068232-4	2015	A bifunctional enzyme was identified in certain bacteria, which catalyzes both NAGS and N-acetylglutamate kinase (NAGK) activities, the first two steps of the arginine biosynthetic pathway.	Arginine	159-167	N-acetylglucosamine kinase	Homo sapiens	114-118
32821748-7	2020	Results: In the control group and ALL patients, p21 Ser/Arg, and MDM2 TG and GG genotypes were associated with significant 1.81-fold (95% confidence interval CI= 1.008-3.267; P < 0.05), 11.07-fold (95% CI= 5.10-24.05; P < 0.0001), and 19.41-fold (95% CI= 8.56-43.99; P < 0.0001) increased risks for ALL, respectively.	Arginine	56-59	H3 histone pseudogene 16	Homo sapiens	48-51
26015579-7	2015	We demonstrate than an N-terminal, arginine/glycine rich, intrinsically disordered protein (IDP) domain of LAF-1 is necessary and sufficient for both phase separation and RNA-protein interactions.	Arginine	35-43	ATP-dependent RNA helicase laf-1	Caenorhabditis elegans	107-112
31813911-5	2020	This case suggests that alterations in this arginine at codon 13 might lead to a common clinical spectrum and further expand the genetic and clinical spectra associated with KIF1A mutations.	Arginine	44-52	kinesin family member 1A	Homo sapiens	174-179
25868907-4	2015	The full-length complementary DNA (cDNA) of the S. kowalevskii tra homolog (Sktra) has a 3786-bp open reading frame that encodes a 1261-amino acid sequence including a TRA-CAM domain and an arginine/serine (RS)-rich domain, both of which are characteristic of TRA orthologs.	Arginine	190-198	transformer	Drosophila melanogaster	63-66
31967473-5	2020	In this study, we analyzed the histone H4 peptide SGRGK incorporating four different posttranslational modifications: citrullination, acetylation, phosphorylation, and arginine methylation at various positions.	Arginine	168-176	H4 clustered histone 6	Homo sapiens	31-41
26020839-0	2015	Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	24-32
26020839-0	2015	Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.	Arginine	0-8	nibrin	Homo sapiens	60-64
26020839-6	2015	The arginines 612, 618, 620, 639, 645, 656 and 661 within the human hnRNPUL1 RGG/RG motifs were substituted with lysines to generate hnRNPUL1(RK).	Arginine	4-13	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	68-76
31932825-3	2020	During Env immunogen production, endogenous furin works to cleave a hexa-arginine motif connecting the gp120 and gp41 subunits, which is needed to ensure proper protein folding and a native-like conformation of Env.	Arginine	73-81	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	103-108
26059767-2	2015	OTC is one of the enzymes common to both the urea cycle and the bacterial arginine biosynthesis pathway; however, the role of OTC has changed over evolution.	Arginine	74-82	ornithine transcarbamylase	Homo sapiens	0-3
26059767-2	2015	OTC is one of the enzymes common to both the urea cycle and the bacterial arginine biosynthesis pathway; however, the role of OTC has changed over evolution.	Arginine	74-82	ornithine transcarbamylase	Homo sapiens	126-129
31641819-8	2020	Pre-treatment with ARG and/or CAR significantly mitigated the neural changes induced by hypoxia and attenuated the elevated levels of NF-kappaB, TNF-alpha, IL-6, caspase-3, and BAX, while ameliorated the reduced levels of Bcl-2, NADR, DOP, SER, and GABA, with the best improvement observed with the combination.	Arginine	19-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	177-180
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	catenin beta 1	Homo sapiens	224-236
31765670-0	2020	Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.	Arginine	21-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	46-52
25715670-3	2015	Previous studies have shown that yeast Hmt1 is a type I PRMT and methylates histone H4 arginine 3 and several mRNA-binding proteins.	Arginine	87-95	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	39-43
25510854-8	2015	However, KACL mutants with non-conservative amino acid substitutions of arginine 158 or isoleucine 161 abrogated binding of both KACL-specific mAb OMA1 and sNKp65, well in line with the blockade of NKp65-KACL interaction by OMA1.	Arginine	72-80	OMA1 zinc metallopeptidase	Homo sapiens	147-151
31765670-0	2020	Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.	Arginine	21-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-92
31765670-0	2020	Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.	Arginine	21-29	NDRG family member 2	Homo sapiens	105-110
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	29-37	NDRG family member 2	Homo sapiens	0-5
25682972-12	2015	EG-induced alterations in electrocardiographic (QRS interval, HR, and ST height) and hemodynamic (SBP, DBP, MABP, and LVEDP) abnormalities were significantly restored by L-arginine (500 and 1000 mg/kg) treatment.	Arginine	170-180	spermine binding protein	Rattus norvegicus	98-101
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	29-37	protein phosphatase 2 phosphatase activator	Homo sapiens	6-10
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	279-287	NDRG family member 2	Homo sapiens	0-5
31765670-4	2020	NDRG2/PP2A complex inhibited arginine methyltransferase activity of PRMT5 through dephosphorylation at Serine 335 (S335); however, in NDRG2low ATL-related cells, highly phosphorylated PRMT5 at S335 was mainly localized in cytoplasm with binding to HSP90A, resulting in enhancing arginine-methylation at the middle domain (R345 and R386).	Arginine	279-287	protein phosphatase 2 phosphatase activator	Homo sapiens	6-10
31765670-5	2020	Since knockdown of PRMT5 expression or forced expression of HSP90A with alanine replacement of R345 or R386 induced apoptosis with the degradation of client proteins in NDRG2low ATL-related and other cancer cells, we here identified that the novel arginine methylations of HSP90A are essential for maintenance of its function in NDRG2low ATL and other cancer cells.	Arginine	248-256	heat shock protein 90 alpha family class A member 1	Homo sapiens	60-66
31765670-5	2020	Since knockdown of PRMT5 expression or forced expression of HSP90A with alanine replacement of R345 or R386 induced apoptosis with the degradation of client proteins in NDRG2low ATL-related and other cancer cells, we here identified that the novel arginine methylations of HSP90A are essential for maintenance of its function in NDRG2low ATL and other cancer cells.	Arginine	248-256	NDRG family member 2	Homo sapiens	169-174
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Arginine	109-112	cell division cycle 27	Homo sapiens	0-4
31765670-5	2020	Since knockdown of PRMT5 expression or forced expression of HSP90A with alanine replacement of R345 or R386 induced apoptosis with the degradation of client proteins in NDRG2low ATL-related and other cancer cells, we here identified that the novel arginine methylations of HSP90A are essential for maintenance of its function in NDRG2low ATL and other cancer cells.	Arginine	248-256	heat shock protein 90 alpha family class A member 1	Homo sapiens	273-279
31765670-5	2020	Since knockdown of PRMT5 expression or forced expression of HSP90A with alanine replacement of R345 or R386 induced apoptosis with the degradation of client proteins in NDRG2low ATL-related and other cancer cells, we here identified that the novel arginine methylations of HSP90A are essential for maintenance of its function in NDRG2low ATL and other cancer cells.	Arginine	248-256	NDRG family member 2	Homo sapiens	329-334
31243342-0	2020	Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70.	Arginine	70-78	protein arginine N-methyltransferase 7	Mus musculus	0-5
25724897-9	2015	The primary KLK4 cleavage site in murine ephrin-B2 was verified and shown to correspond to one of the in silico predicted sites between extracellular domain residues arginine 178 and asparagine 179.	Arginine	166-174	ephrin B2	Mus musculus	41-50
31243342-6	2020	The mechanistic study reveals that Prmt7 methylates p38MAPKalpha at the arginine residue 70, thereby promoting its activation which in turn enhances MyoD activities.	Arginine	72-80	protein arginine N-methyltransferase 7	Mus musculus	35-40
31243342-6	2020	The mechanistic study reveals that Prmt7 methylates p38MAPKalpha at the arginine residue 70, thereby promoting its activation which in turn enhances MyoD activities.	Arginine	72-80	myogenic differentiation 1	Mus musculus	149-153
25826076-0	2015	Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.	Arginine	85-93	microRNA 122	Mus musculus	10-16
31243342-8	2020	In conclusion, Prmt7 promotes MyoD-mediated myoblast differentiation through methylation of p38MAPKalpha at arginine residue 70.	Arginine	108-116	protein arginine N-methyltransferase 7	Mus musculus	15-20
25826076-3	2015	Because deregulated amino acid levels in cancers can affect their biological behavior, we determined the amino acid levels in miR122-silenced mouse liver tissues, in which intracellular arginine levels were significantly increased.	Arginine	186-194	microRNA 122	Mus musculus	126-132
25826076-4	2015	The increased intracellular arginine levels were through upregulation of the solute carrier family 7 (SLC7A1), a transporter of arginine and a direct target of miR122.	Arginine	28-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	102-108
31243342-8	2020	In conclusion, Prmt7 promotes MyoD-mediated myoblast differentiation through methylation of p38MAPKalpha at arginine residue 70.	Arginine	108-116	myogenic differentiation 1	Mus musculus	30-34
25826076-4	2015	The increased intracellular arginine levels were through upregulation of the solute carrier family 7 (SLC7A1), a transporter of arginine and a direct target of miR122.	Arginine	28-36	microRNA 122	Mus musculus	160-166
25826076-4	2015	The increased intracellular arginine levels were through upregulation of the solute carrier family 7 (SLC7A1), a transporter of arginine and a direct target of miR122.	Arginine	128-136	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	102-108
31996674-3	2020	Here we show that pi-stacking by Arginine side-chains drives protein binding to Tau fibrils.	Arginine	33-41	microtubule associated protein tau	Homo sapiens	80-83
25826076-6	2015	Conversely, maintenance of the miR122-silenced HCC cells in arginine-depleted culture media, as well as overexpression of miR122 in miR122-low-expressing HCC cells, reversed these effects and rendered the cells more sensitive to sorafenib.	Arginine	60-68	microRNA 122	Mus musculus	31-37
31985312-3	2021	DNA sequencing showed a mutation of codon 46 and it was named Hb Cenxi [beta46(CD5)Gly Arg (GGG>CGG), HBB: c.139G>C] for the city of birth of the proband.	Arginine	87-90	CD5 molecule	Homo sapiens	79-82
25666610-8	2015	Recruitment of WDR5 to the midbody dark zone appears to require integrity of the WDR5 central arginine-binding cavity, as mutations that disrupt histone H3 and MLL1 binding to this pocket also abolish the midbody localization of WDR5.	Arginine	94-102	lysine methyltransferase 2A	Homo sapiens	160-164
25557051-5	2015	The replacement of the Lys or Arg linker with the betaAla or Ahx linker retained nanomolar receptor-binding affinities and remarkable cytotoxicity of RGD-betaAla-(Arg(11))CCMSH and RGD-Ahx-(Arg(11))CCMSH.	Arginine	30-33	nuclear receptor subfamily 0, group B, member 1	Mus musculus	185-188
25557051-5	2015	The replacement of the Lys or Arg linker with the betaAla or Ahx linker retained nanomolar receptor-binding affinities and remarkable cytotoxicity of RGD-betaAla-(Arg(11))CCMSH and RGD-Ahx-(Arg(11))CCMSH.	Arginine	163-166	nuclear receptor subfamily 0, group B, member 1	Mus musculus	61-64
25557051-5	2015	The replacement of the Lys or Arg linker with the betaAla or Ahx linker retained nanomolar receptor-binding affinities and remarkable cytotoxicity of RGD-betaAla-(Arg(11))CCMSH and RGD-Ahx-(Arg(11))CCMSH.	Arginine	163-166	nuclear receptor subfamily 0, group B, member 1	Mus musculus	61-64
25557051-8	2015	The replacement of the Arg linker with the betaAla or Ahx linker reduced the non-specific renal uptake of (99m)Tc-RGD-betaAla-(Arg(11))CCMSH and (99m)Tc-RGD-Ahx-(Arg(11))CCMSH by 62 and 61 % at 2 h post-injection.	Arginine	23-26	nuclear receptor subfamily 0, group B, member 1	Mus musculus	157-160
31869665-8	2020	IIIM-1266 and IIIM-1270 displayed bidentate H-bonding with Arg 346 and Glu 305 residues in the active site of ER-beta; and they also strongly occupied the ADP-binding site of NLRP3 protein.	Arginine	59-62	estrogen receptor 1 (alpha)	Mus musculus	110-117
31816575-1	2020	Peptidyl arginine deiminase-4 (PAD4), a PAD enzyme family member, catalyzes the posttranslational conversion of arginine residues to citrulline in target proteins.	Arginine	9-17	peptidyl arginine deiminase 4	Homo sapiens	31-35
25637053-7	2015	Accordingly, the shedding of the transferrin receptor-2 variant G679A, mutated in the Arginine-Glycine-Aspartic acid motif and unable to bind diferric transferrin, is not modulated by the ligand.	Arginine	86-94	transferrin receptor 2	Homo sapiens	33-55
25749046-6	2015	The underlying mechanism is complex, but increased DNA damage upon arginine deprivation due to decreased DNA repair proteins, FANCD2, ATM, and CHK1/2 most likely leads to increased apoptosis.	Arginine	67-75	ATM serine/threonine kinase	Homo sapiens	134-137
31425999-5	2019	Molecular simulation results indicated that diPAPs and E2 could bind to one common residue, arginine (Arg) 87, in the binding pocket of ERbeta2, inducing similar estrogenic disruption mechanisms as E2.	Arginine	92-100	estrogen receptor 2a	Danio rerio	136-143
25475372-8	2015	By using liquid chromatography - tandem mass spectrometry (LC-MS/MS) analysis of immunoprecipitated MYCN protein, we identified several potential sites of arginine dimethylation on the MYCN protein.	Arginine	155-163	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	100-104
25475372-8	2015	By using liquid chromatography - tandem mass spectrometry (LC-MS/MS) analysis of immunoprecipitated MYCN protein, we identified several potential sites of arginine dimethylation on the MYCN protein.	Arginine	155-163	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	185-189
31425999-5	2019	Molecular simulation results indicated that diPAPs and E2 could bind to one common residue, arginine (Arg) 87, in the binding pocket of ERbeta2, inducing similar estrogenic disruption mechanisms as E2.	Arginine	102-105	estrogen receptor 2a	Danio rerio	136-143
25416155-6	2015	Mutation of the Arg residues preceding the PKA phosphorylation site (Thr35) to Ala (R/A(30-33)) abolished I-1 phosphorylation and its binding to and inhibition of PP1c.	Arginine	16-19	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	43-46
31832004-0	2019	Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis.	Arginine	93-103	fibronectin type III domain containing 5	Homo sapiens	0-6
25540195-3	2015	Arg has two distinct actin-binding domains and interacts physically and functionally with cortactin, an activator of the Arp2/3 complex.	Arginine	0-3	actin related protein 2	Homo sapiens	121-125
25540195-7	2015	Arg stimulates formation of actin filament branches by Arp2/3 complex and cortactin.	Arginine	0-3	actin related protein 2	Homo sapiens	55-59
31180587-7	2019	Meanwhile, we found that HK-2 cells exposed to H/R treatment incubated with hBMSC-Exos decreased semaphorin 3A (Sema3A) and activated the protein kinase B (AKT) and extracellular-signal-regulated kinase (ERK) pathways.	Arginine	49-50	protein tyrosine kinase 2 beta	Homo sapiens	138-154
25540195-8	2015	An Arg mutant lacking the C-terminal calponin homology actin-binding domain stimulates actin branch formation by the Arp2/3 complex, indicative of autoinhibition.	Arginine	3-6	actin related protein 2	Homo sapiens	117-121
31772215-5	2019	Mutations affecting arginine residues in the fourth transmembrane helix (S4) of the NaV1.4 VSDs can result in a leak current through the VSD and hypokalemic periodic paralysis (HypoPP), but these have hitherto not been associated with myotonia.	Arginine	20-28	sodium voltage-gated channel alpha subunit 4	Homo sapiens	84-90
25699100-8	2015	Notably, GP IIb/IIIa expression was associated with the vulnerability index and necrotic center/fiber cap ratio (P&lt;0.05), and contrast video intensity from adhered cyclic Arg-Gly-Asp-modified MBs (MB-cRGDs) was correlated with GP IIb/IIIa expression on the plaque surface (P&lt;0.05).	Arginine	174-177	integrin alpha 2b	Mus musculus	9-15
25492936-1	2015	ASS1 is a cytosolic enzyme that plays a role in the conversion of citrulline to arginine.	Arginine	80-88	argininosuccinate synthase 1	Homo sapiens	0-4
31772215-6	2019	We report a patient with an Nav1.4 S4 arginine mutation, R222Q, presenting with severe myotonia without fulminant paralytic episodes.	Arginine	38-46	sodium voltage-gated channel alpha subunit 4	Homo sapiens	28-34
31615893-9	2019	Docking experiments suggested a pivotal role of Arg-635 at the entrance of the binding pocket in HCN2, either causing stabilizing cation-pi interactions with the aromatic ring in N 6-Phe-cAMP or N 6-Bn-cAMP or a steric clash with the aromatic ring in N 6-Bnz-cAMP.	Arginine	48-51	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	Mus musculus	97-101
25460538-6	2015	Administration of morphine or L-arginine prior to chronic RS did not influence such chronic stress induced changes in behavioral and biochemical markers, but appreciably attenuated chronic RS induced elevation in Hsp70 levels.	Arginine	30-40	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	213-218
31492534-4	2019	The PDZ binding motif (PBM) and an Arg-rich motif upstream of PBM conserved in TARPs bind to multiple sites on PSD-95, thus resulting in a highly specific and multivalent stargazin/PSD-95 complex.	Arginine	35-38	calcium channel, voltage-dependent, gamma subunit 2	Mus musculus	171-180
25569455-5	2015	Acetylation-defective c-MYC Lys Arg substitution mutants are impaired for oncogenic transformation with p30(II) in c-myc(-/-) HO15.19 fibroblasts.	Arginine	32-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
25569455-5	2015	Acetylation-defective c-MYC Lys Arg substitution mutants are impaired for oncogenic transformation with p30(II) in c-myc(-/-) HO15.19 fibroblasts.	Arginine	32-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	115-120
31237021-8	2019	Thus the energetically destructive changeover of ARG to HIS in R612H could possibly affect the LEPR protein structural stability and functional constancy due to interruption in the amino acid interactions and could result in reproductive disorders in human and increases the complication in obstetric and pregnancy outcome.	Arginine	49-52	leptin receptor	Homo sapiens	95-99
31492697-2	2019	To check wheth er peptides built exclusively from arginine residues will interact with different nAChR subtypes or with such their structural homologues as the acetylcholine binding protein and ligand binding domain of nAChR alpha9 subunit, we synthesized a series of R3, R6, R8 and R16 oligoarginines and investigate their activity by competition with radioiodinated alpha- bungarotoxin, by two electrode voltage clamp electrophysiology and calcium imaging.	Arginine	50-58	cholinergic receptor nicotinic alpha 9 subunit	Homo sapiens	219-231
31603552-1	2019	OBJECTIVE: To describe the role of biochemical anomalies of tyrosine (TYR), tryptophan (TRP), and arginine (ARG) metabolism in patients suffering from episodic and chronic cluster headache (CCH).	Arginine	98-106	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	108-111
31302167-4	2019	Arginine 51 of S100A3 protein is citrullinated specifically by peptidylarginine deiminase 3 (PAD3), and this citrullination is related to maturation of the cuticle.	Arginine	0-8	S100 calcium binding protein A3	Homo sapiens	15-21
31132406-8	2019	Lorecivivint inhibited CLK2-mediated phosphorylation of serine/arginine-rich (SR) splicing factors and DYRK1A-mediated phosphorylation of SIRT1 and FOXO1.	Arginine	63-71	CDC like kinase 2	Homo sapiens	23-27
31113844-0	2019	Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.	Arginine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
31113844-0	2019	Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	117-121
31113844-1	2019	PURPOSE: The response to acute and long-term arginine starvation results in a conditional adaptive metabolic reprogramming that can be harnessed for therapeutic opportunities in ASS1-negative tumors.	Arginine	45-53	argininosuccinate synthase 1	Homo sapiens	178-182
31164374-7	2019	MYC-driven SCLC preferentially depends on arginine-regulated pathways including polyamine biosynthesis and mTOR pathway activation.	Arginine	42-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
31164374-11	2019	CONCLUSIONS: These data identify metabolic heterogeneity within SCLC and suggest arginine deprivation as a subtype-specific therapeutic vulnerability for MYC-driven SCLC.	Arginine	81-89	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	154-157
31256937-4	2019	Previously, we reported a novel SGD patient who had a homozygous mutation for two amino acids, arginine (R247) and serine (S248), which were deleted in the basic leucine zipper domain of C/EBPepsilon (DeltaRS) and exhibited loss of transcriptional activity with aberrant protein-protein interactions.	Arginine	95-103	CCAAT enhancer binding protein epsilon	Homo sapiens	187-199
31070279-0	2019	The arginine and serine-rich domains of Acinus modulate splicing.	Arginine	4-12	apoptotic chromatin condensation inducer 1	Homo sapiens	40-46
31070279-5	2019	In contrast, we observed that the tethering of arginine/serine (RS) and RNPS1-SAP18-binding (RSB) domains of Acinus could regulate the selection of alternative splice sites, thereby revealing the potential of Acinus in stimulating alternative splicing.	Arginine	47-55	apoptotic chromatin condensation inducer 1	Homo sapiens	109-115
31070279-5	2019	In contrast, we observed that the tethering of arginine/serine (RS) and RNPS1-SAP18-binding (RSB) domains of Acinus could regulate the selection of alternative splice sites, thereby revealing the potential of Acinus in stimulating alternative splicing.	Arginine	47-55	apoptotic chromatin condensation inducer 1	Homo sapiens	209-215
31267554-0	2019	Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids.	Arginine	0-8	DEAD-box helicase 5	Homo sapiens	28-32
31150637-3	2019	Positively charged arginine (R) and histidine (H) of mouse AQP0 ELA and ELC were substituted individually with glutamine (Q) to create R33Q, H40Q, R113Q and H122Q by mutagenesis.	Arginine	19-27	apelin receptor early endogenous ligand	Mus musculus	64-67
30980593-9	2019	We also looked into the mCG DNA binding ability of some invertebrates MBD2/3 and found that the conserved arginine fingers and a conserved structural fold are required for methylated DNA binding by MBD2/3-MBDs in invertebrates.	Arginine	106-114	methyl-CpG binding domain protein 2	Homo sapiens	70-76
30980593-9	2019	We also looked into the mCG DNA binding ability of some invertebrates MBD2/3 and found that the conserved arginine fingers and a conserved structural fold are required for methylated DNA binding by MBD2/3-MBDs in invertebrates.	Arginine	106-114	methyl-CpG binding domain protein 2	Homo sapiens	70-74
30980593-10	2019	Hence, our results demonstrate that mCG-binding arginine fingers embedded into a conserved structural fold are essential structural features for MBD2/3s binding to methylated DNA among metazoans.	Arginine	48-56	methyl-CpG binding domain protein 2	Homo sapiens	145-151
31147442-3	2019	JMJD6 is also reported to catalyze N-demethylation of N-methylated (both mono- and di-methylated) arginine residues of histones and other proteins, including HSP70 (heat-shock protein 70), estrogen receptor alpha, and RNA helicase A.	Arginine	98-106	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
31360909-2	2019	Inhibitors of an arginine-binding cavity in WDR5, known as the WDR5-interaction (WIN) site, have been proposed to selectively kill MLL-rearranged malignancies via an epigenetic mechanism.	Arginine	17-25	lysine methyltransferase 2A	Homo sapiens	131-134
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Arginine	45-55	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	16-20
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Arginine	45-55	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	17-20
31249870-2	2019	Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism.	Arginine	36-44	E2F transcription factor 1	Homo sapiens	80-84
25635834-3	2015	Supplementation with 1% L-arginine did not affect the growth performance or carcass traits, while it increased IMF content by 32% (P &lt; 0.01), it also decreased the drip loss at 48 h post-mortem and the b* meat color value at 24 h post-mortem; supplementation with 1% dietary L-arginine did not change the proportion of SFA and MUFA in muscle lipids.	Arginine	24-34	IMF	Sus scrofa	111-114
31249870-6	2019	Our results reveal an unexpected consequence of arginine methylation, where reader-writer interplay widens the mechanism of control by E2F1, from transcription factor to regulator of alternative RNA splicing, thereby extending the genomic landscape under E2F1 control.	Arginine	48-56	E2F transcription factor 1	Homo sapiens	135-139
31249870-6	2019	Our results reveal an unexpected consequence of arginine methylation, where reader-writer interplay widens the mechanism of control by E2F1, from transcription factor to regulator of alternative RNA splicing, thereby extending the genomic landscape under E2F1 control.	Arginine	48-56	E2F transcription factor 1	Homo sapiens	255-259
25635834-6	2015	It is suggested that the proteome changes in longissimus muscle contributed to the greater IMF content in L-arginine supplemented pigs.	Arginine	106-116	IMF	Sus scrofa	91-94
31235809-7	2019	Phosphorylation at this site is necessary for PRMT1-dependent protein arginine methylation.	Arginine	70-78	protein arginine N-methyltransferase 1	Mus musculus	46-51
31073031-7	2019	Mutagenesis of conserved arginine residues within the C-terminal coiled-coil disrupted oligomerization, binding, and function of Coy1.	Arginine	25-33	Coy1p	Saccharomyces cerevisiae S288C	129-133
25416785-0	2015	Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.	Arginine	131-139	Parkinsonism associated deglycase	Homo sapiens	32-36
25416785-0	2015	Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.	Arginine	131-139	Parkinsonism associated deglycase	Homo sapiens	37-42
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	117-125	ribosomal protein S6 kinase B1	Homo sapiens	181-185
25416785-4	2015	DJ-1 deglycates cysteines, arginines, and lysines (the three major glycated amino acids) of serum albumin, glyceraldehyde-3-phosphate dehydrogenase, aldolase, and aspartate aminotransferase and thus reactivates these proteins.	Arginine	27-36	Parkinsonism associated deglycase	Homo sapiens	0-4
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	149-157	ribosomal protein S6 kinase B1	Homo sapiens	181-185
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	63-71	ribosomal protein S6 kinase B1	Homo sapiens	90-94
30802296-6	2019	The remaining enzymes, Adam19 and Furin, were found to be capable of cleavage at arginine residues, and inhibitors for both proteases were added to cell-free media to determine if the product degradation could be reduced.	Arginine	81-89	furin	Cricetulus griseus	34-39
30877024-0	2019	Altered neurovascular coupling and brain arginine metabolism in endothelial nitric oxide synthase deficient mice.	Arginine	41-49	nitric oxide synthase 3, endothelial cell	Mus musculus	64-97
25324168-2	2015	In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2.	Arginine	71-79	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-15
25324168-2	2015	In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2.	Arginine	71-79	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	102-106
25324168-2	2015	In gliomas, IDH mutations uniformly occur in the functionally critical arginine 132 residue (R132) of IDH1 and arginine 172 residue (R172) of IDH2.	Arginine	111-119	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-15
30789755-3	2019	This review overviews our present understanding of the posttranslational regulation of the muscle cytoskeleton through arginylation, a tRNA-dependent addition of arginine to proteins mediated by arginyltransferase 1.	Arginine	162-170	arginyltransferase 1	Homo sapiens	195-215
25666040-4	2015	We investigate the ability of analogues of the heptapeptide H-Arg-Lys-Val-MePhe-Tyr-Thr-Trp- OH2, an inhibitor of Abeta-peptide aggregation, to cross-react with alpha-synuclein interfering with its fibril formation.	Arginine	62-65	synuclein alpha	Homo sapiens	161-176
26095376-1	2015	An alpha-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective.	Arginine	66-69	metallothionein 2A	Homo sapiens	37-41
30796035-3	2019	Preclinically, we showed that HGGs are a target for arginine depletion with pegargiminase (ADI-PEG20) due to epimutations of argininosuccinate synthetase (ASS1) and/or argininosuccinate lyase (ASL).	Arginine	52-60	argininosuccinate synthase 1	Homo sapiens	155-159
30236171-3	2019	Arginine methylation is a common posttranslational modification generated mostly by a single protein, PRMT1.	Arginine	0-8	protein arginine N-methyltransferase 1	Mus musculus	102-107
31058095-5	2019	Although peptidyl arginine deiminase-2 and -4 (PADI2 and PADI4, respectively) can catalyze the conversion of arginine to citrulline, we observed that only PADI4 expression correlated with the citrulline histone modification of H3R26Cit.	Arginine	18-26	peptidyl arginine deiminase 4	Homo sapiens	57-62
31058095-5	2019	Although peptidyl arginine deiminase-2 and -4 (PADI2 and PADI4, respectively) can catalyze the conversion of arginine to citrulline, we observed that only PADI4 expression correlated with the citrulline histone modification of H3R26Cit.	Arginine	18-26	peptidyl arginine deiminase 4	Homo sapiens	155-160
30871006-8	2019	Replacement of K1240 by arginine results in fewer cells displaying centromeric TOP2A accumulation during prometaphase-metaphase.	Arginine	24-32	DNA topoisomerase II alpha	Homo sapiens	79-84
30832686-1	2019	BACKGROUND: y+LAT1, encoded by SCL7A7, is the protein mutated in Lysinuric Protein Intolerance (LPI), a rare metabolic disease caused by a defective cationic amino acid (CAA, arginine, lysine, ornithine) transport at the basolateral membrane of intestinal and renal tubular cells.	Arginine	175-183	solute carrier family 7 member 7	Homo sapiens	12-18
30832686-8	2019	The different effect of y+LAT1 mutation on arginine transport in monocytes and lymphoblasts is supposed to be due to the different expression of SLC7A7 mRNA in the two models, supporting the hypothesis that the impact of LPI defect largely depends on the relative abundance of LPI target gene in each cell type.	Arginine	43-51	solute carrier family 7 member 5	Homo sapiens	26-30
30605863-8	2019	However, the progression of arginine non-auxotrophic tumors is independent of exogenous l-arginine, because these tumors have arginine-succinate synthetase (ASS1) activity and are available to produce l-arginine from citrulline.	Arginine	28-36	argininosuccinate synthase 1	Homo sapiens	157-161
31221062-1	2019	Mutations in the LMNA gene resulting in the substitution of the highly conserved arginine 482 residue in the globular C-terminal domain of lamin A/C are associated with the Dunnigan-type familial partial lipodystrophy (FPLD2) often accompanied by impairments in the muscle tissue development.	Arginine	81-89	lamin A	Mus musculus	17-21
31221062-1	2019	Mutations in the LMNA gene resulting in the substitution of the highly conserved arginine 482 residue in the globular C-terminal domain of lamin A/C are associated with the Dunnigan-type familial partial lipodystrophy (FPLD2) often accompanied by impairments in the muscle tissue development.	Arginine	81-89	lamin A	Mus musculus	139-148
30590162-8	2019	Surplus arginine significantly reduced IL-8, Cox2 and TNF-alpha transcription in head kidney cells.	Arginine	8-16	prostaglandin G/H synthase 2	Salmo salar	45-49
30590162-13	2019	In liver cells, protein expression of catalase was reduced by surplus arginine alone and when challenged with poly I:C. Both liver cells and head kidney cells isolated from the same individual fish responded to LPS and poly I:C, depending on the gene analyzed.	Arginine	70-78	catalase	Salmo salar	38-46
30590246-5	2019	In addition, l-arginine could increase pregnancy rate and decrease fetal resorption rate in females mated with T-2 toxin exposed males.	Arginine	13-23	brachyury 2	Mus musculus	111-114
30590246-6	2019	Collectively, these findings suggest that dietary l-arginine supplementation may protect male reproductive impairments in mice treated with T-2 toxin through improving semen quality and serum testosterone levels.	Arginine	50-60	brachyury 2	Mus musculus	140-143
29607617-7	2019	RESULTS: A novel heterozygous missense mutation c.3550 C&gt;T in the coding region of the DSP gene, predicting substitution of arginine (Arg,R) by tryptophan (Trp,W) in the desmoplakin polypeptide, was discovered in a Chinese pedigree of PPK.	Arginine	127-135	desmoplakin	Homo sapiens	90-93
29607617-7	2019	RESULTS: A novel heterozygous missense mutation c.3550 C&gt;T in the coding region of the DSP gene, predicting substitution of arginine (Arg,R) by tryptophan (Trp,W) in the desmoplakin polypeptide, was discovered in a Chinese pedigree of PPK.	Arginine	137-140	desmoplakin	Homo sapiens	90-93
29959905-3	2019	Furthermore, two CXCL14-C17 analogs (CXCL14-C17-a1 and CXCL14-C17-a3) with improved cell selectivity were engineered by introducing Lys, Arg, or Trp in CXCL14-C17.	Arginine	137-140	cytokine like 1	Homo sapiens	24-27
30321592-5	2019	Interestingly, the CCR2 receptor isoforms are identical up to arginine 313 (R313) that is part of the putative 8th helix in CCR2 receptors, and the 8th helix has been implicated in the interaction of rhodopsin-like G protein-coupled receptors with Galphaq.	Arginine	62-70	G protein subunit alpha q	Homo sapiens	248-255
30355733-2	2018	We have also reported that the C-terminal tail sequence beyond the C/EBPbeta leucine zipper is critical for its association with Spi1 via an exposed residue (Arg-232) located within a pocket at one end of the Spi1 DNA-recognition helix.	Arginine	158-161	Spi-1 proto-oncogene	Homo sapiens	129-133
30355733-2	2018	We have also reported that the C-terminal tail sequence beyond the C/EBPbeta leucine zipper is critical for its association with Spi1 via an exposed residue (Arg-232) located within a pocket at one end of the Spi1 DNA-recognition helix.	Arginine	158-161	Spi-1 proto-oncogene	Homo sapiens	209-213
30355733-3	2018	Here, combining in vitro interaction studies with computational docking and molecular dynamics of existing X-ray structures for the Spi1 and C/EBPbeta DBDs, along with the C/EBPbeta C-terminal tail sequence, we found that the tail sequence is intimately associated with Arg-232 of Spi1.	Arginine	270-273	Spi-1 proto-oncogene	Homo sapiens	132-136
30559217-2	2018	Most KARs contain the subunit GluK2 (also known as GRIK2), and the properties of these receptors are determined in part by ADAR2 (also known as ADARB1)-mediated mRNA editing of GluK2, which changes a genomically encoded glutamine residue into an arginine residue (Q/R editing).	Arginine	246-254	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	30-35
30559217-2	2018	Most KARs contain the subunit GluK2 (also known as GRIK2), and the properties of these receptors are determined in part by ADAR2 (also known as ADARB1)-mediated mRNA editing of GluK2, which changes a genomically encoded glutamine residue into an arginine residue (Q/R editing).	Arginine	246-254	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	51-56
30559217-2	2018	Most KARs contain the subunit GluK2 (also known as GRIK2), and the properties of these receptors are determined in part by ADAR2 (also known as ADARB1)-mediated mRNA editing of GluK2, which changes a genomically encoded glutamine residue into an arginine residue (Q/R editing).	Arginine	246-254	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	177-182
30546006-3	2018	We previously showed that a subset of GBM are arginine auxotrophic because of transcriptional silencing of ASS1 and/or ASL and are sensitive to pegylated arginine deiminase (ADI-PEG20).	Arginine	46-54	argininosuccinate synthase 1	Homo sapiens	107-111
30280600-3	2018	In clear cell renal cell carcinoma (RCC), which is now considered a metabolic disease, we and others have shown derangements in the enzyme arginosuccinate synthase 1 (ASS1), resulting in RCC cells becoming auxotrophic for arginine and leading to a new therapeutic paradigm involving reducing extracellular arginine.	Arginine	222-230	argininosuccinate synthetase 1	Mus musculus	167-171
30280600-3	2018	In clear cell renal cell carcinoma (RCC), which is now considered a metabolic disease, we and others have shown derangements in the enzyme arginosuccinate synthase 1 (ASS1), resulting in RCC cells becoming auxotrophic for arginine and leading to a new therapeutic paradigm involving reducing extracellular arginine.	Arginine	306-314	argininosuccinate synthetase 1	Mus musculus	167-171
30280600-5	2018	We now show that, in a remarkable parallel to RCC, ASS1 expression is reduced in murine and human ADPKD, and arginine depletion results in a dose-dependent compensatory increase in ASS1 levels as well as decreased cystogenesis in vitro and ex vivo with minimal toxicity to normal cells.	Arginine	109-117	argininosuccinate synthase 1	Homo sapiens	181-185
30253213-7	2018	In line with computational studies, biosensor-based structure-kinetic relationship studies demonstrated that 6-O-sulfo groups of d-glucosamine residue were essential in binding to arginines of both TLR4 and MD2 domains of the receptor complex.	Arginine	180-189	toll like receptor 4	Homo sapiens	198-202
29986157-4	2018	PRMT1 is the most highly expressed of the protein arginine methyltransferases, enzymes responsible for methylation of arginine motifs on histone and nonhistone proteins.	Arginine	50-58	protein arginine N-methyltransferase 1	Mus musculus	0-5
30504773-8	2018	PRMT1 interacts with and methylates CaMKII at arginine residues 9 and 275, leading to its inhibition.	Arginine	46-54	protein arginine N-methyltransferase 1	Mus musculus	0-5
28090171-5	2015	Activated PRMPT5 causes arginine methylation of p53 to suppress expression of pro-apoptotic and anti-proliferative target genes, explaining the molecular mechanism for tumorigenesis.	Arginine	24-32	transformation related protein 53, pseudogene	Mus musculus	48-51
30282806-7	2018	Site-directed mutagenesis further revealed that Asp-148, Arg-150, and Ser-151 cluster in a peptide loop essential for binding to Nav1.5.	Arginine	57-60	sodium voltage-gated channel alpha subunit 5	Homo sapiens	129-135
30239898-7	2018	Solution NMR structure indicated that KR12C, the best peptide candidate, selectively stabilized the 5"-propeller loop of c-MYC quadruplex by arginine-driven electrostatic-interactions at the sugar-phosphate backbone while KR12A peptide destabilized the quadruplex inducing a single-stranded hairpin-like conformation.	Arginine	141-149	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	121-126
25535719-5	2014	The human demethyliminase (PADI4) converts monomethyl arginine residue to citrulline by the arginine demethylimination.	Arginine	54-62	peptidyl arginine deiminase 4	Homo sapiens	27-32
25187572-4	2014	O-GlcNAc modification occurs in close proximity to phosphorylated residues and novel sites of arginine methylation within regions known to regulate Runx2 transactivation.	Arginine	94-102	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-8
30044662-2	2018	The importance of the arginine at position 76 (Arg76) in the structure and/or function of connexin 46 (Cx46) is highlighted by its conservation across the entire connexin family and the occurrence of pathogenic mutations at this (or the corresponding homologous) residue in a number of human diseases.	Arginine	22-30	gap junction protein alpha 3	Homo sapiens	90-101
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Arginine	77-85	transformation related protein 53, pseudogene	Mus musculus	4-7
25429397-4	2014	The p53-bcl-2 mRNA interaction is modified by the substitution of proline by arginine within the p53 proline-rich domain (PRD).	Arginine	77-85	transformation related protein 53, pseudogene	Mus musculus	97-100
25429397-6	2014	Also, the p53(Arg) compared with p53(Pro) displays higher affinity to and activates the promoter region of SAM-pointed domain-containing Ets-like factor (SPDEF), a driver of mucous differentiation.	Arginine	14-17	transformation related protein 53, pseudogene	Mus musculus	10-13
30044662-2	2018	The importance of the arginine at position 76 (Arg76) in the structure and/or function of connexin 46 (Cx46) is highlighted by its conservation across the entire connexin family and the occurrence of pathogenic mutations at this (or the corresponding homologous) residue in a number of human diseases.	Arginine	22-30	gap junction protein alpha 3	Homo sapiens	103-107
25419572-2	2014	OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Ser-Val-Val-Tyr-Gly-Leu-Arg sequences located in the N-terminal part of the protein.	Arginine	78-81	secreted phosphoprotein 1	Homo sapiens	0-3
25419572-2	2014	OPN primarily exerts its functions through interaction with integrins via the Arg-Gly-Asp and Ser-Val-Val-Tyr-Gly-Leu-Arg sequences located in the N-terminal part of the protein.	Arginine	118-121	secreted phosphoprotein 1	Homo sapiens	0-3
30321814-1	2018	Protein arginine methyltransferase 1 (PRMT1) catalyzes the asymmetric dimethylation of arginine residues in proteins and methylation of various RNA-binding proteins and is associated with alternative splicing in vitro.	Arginine	8-16	protein arginine N-methyltransferase 1	Mus musculus	38-43
30410484-2	2018	Previous genetic studies identified a natural variant of Vav1 characterized by the substitution of an arginine (R) residue by a tryptophane (W) at position 63 (Vav1R63W).	Arginine	102-110	vav 1 oncogene	Mus musculus	57-61
25263501-10	2014	LPS/D-GalN-induced inflammation, as confirmed by the increased MPO activity, created an asymmetrical distribution of arginine and ADMA between the tissue and plasma.	Arginine	117-125	myeloperoxidase	Rattus norvegicus	63-66
29807069-13	2018	l-Arginine lowered the brain oxidative stress, inflammation, AChE activity, eNOS expression (not activity), NFkappaB levels and elevated nitrite content.	Arginine	0-10	acetylcholinesterase	Rattus norvegicus	61-65
30208316-3	2018	PUFA analogs are critically dependent on K326 in S6 of KV7.1 to increase the maximum conductance and critically dependent on specific S4 arginines in KV7.1 to shift the voltage dependence of channel opening toward negative voltages.	Arginine	137-146	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	150-155
29931243-6	2018	The Arg treatment significantly increased the serum insulin concentration at 3 h post-infusion compared with the saline treatment (P &lt; 0.05), and that of LPS and LPS + Arg treatments were in between Arg and LPS treatments.	Arginine	4-7	insulin	Bos taurus	52-59
29453600-5	2018	In humans, arginine is a semi-essential amino acid and its synthesis enzyme argininosuccinate synthetase (ASS1) represents the rate-limiting step in arginine biosynthesis.	Arginine	149-157	argininosuccinate synthase 1	Homo sapiens	106-110
29453600-6	2018	Neoplasms that show low to absent ASS1 expression require extracellular arginine for cancer cell survival, and thus can be targeted using arginine-degrading enzymes such as pegylated arginine deiminase (ADI-PEG 20).	Arginine	72-80	argininosuccinate synthase 1	Homo sapiens	34-38
29453600-6	2018	Neoplasms that show low to absent ASS1 expression require extracellular arginine for cancer cell survival, and thus can be targeted using arginine-degrading enzymes such as pegylated arginine deiminase (ADI-PEG 20).	Arginine	138-146	argininosuccinate synthase 1	Homo sapiens	34-38
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	39-44	calcium sensing receptor	Sus scrofa	210-214
30088839-5	2018	In this study, we investigated whether l-Arginine (l-Arg) could induce gut hormones cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP) secretion in the porcine duodenum and if so, whether CaSR mediated l-Arg-regulated gut satiety hormone secretion.	Arginine	51-56	calcium sensing receptor	Sus scrofa	210-214
30088839-8	2018	The potency of l-Arg to induce CCK and GIP secretion was enhanced in the presence of extracellular Ca2+ and CaSR agonist cinacalcet.	Arginine	15-20	calcium sensing receptor	Sus scrofa	108-112
30088839-9	2018	However, the effect of Arg on CCK and GIP secretion was attenuated by blocking CaSR and its downstream signaling molecules adenylate cyclase (AC) and phospholipase C (PLC).	Arginine	23-26	calcium sensing receptor	Sus scrofa	79-83
30088839-12	2018	PRACTICAL APPLICATION: l-Arginine is able to modulate cholecystokinin and glucose-dependent insulinotropic peptide secretion through the CaSR in pig model, which has a potential role in regulating food intake and blood glucose levels.	Arginine	23-33	calcium sensing receptor	Sus scrofa	137-141
29908255-0	2018	Genetic overexpression of glutathione peroxidase-1 attenuates microcystin-leucine-arginine-induced memory impairment in mice.	Arginine	82-90	glutathione peroxidase 1	Mus musculus	26-50
30054435-5	2018	In the present study, the effects of Pb on the PRMT5 and MEP50 expression and formation of the symmetrically dimethylated arginine (SDMA), the catalytic product of the PRMT5-MEP50 complex were analyzed in vitro after exposing the A549 and MCF-7 cells.	Arginine	122-130	WD repeat domain 77	Homo sapiens	174-179
30134162-0	2018	Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA.	Arginine	34-42	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	95-99
30134162-8	2018	Collectively, our data elucidate the origin of protein arginine methylation and its use by MidA/NDUFAF7 to regulate CI assembly.	Arginine	55-63	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	91-95
30134162-8	2018	Collectively, our data elucidate the origin of protein arginine methylation and its use by MidA/NDUFAF7 to regulate CI assembly.	Arginine	55-63	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	96-103
30057274-6	2018	Mechanistically, the loss of arginine methylation at R554 of the PDGFRalpha intracellular domain unmasks a Cbl binding site at Y555.	Arginine	29-37	Casitas B-lineage lymphoma	Mus musculus	107-110
29928903-7	2018	RESULTS: We discovered trypsin-like activity in KLK15, finding that it cleaves preferentially after arginine (R).	Arginine	100-108	kallikrein related peptidase 15	Homo sapiens	48-53
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Arginine	287-290	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	103-109
30058071-5	2018	An investigation into the interaction between the Shank SH3 domains and the proline-rich region of the Cav1.3 calcium channel revealed an atypical interaction in which the highly acidic specificity binding pocket of the SH3 domains binds to a Cav1.3 region containing a cluster of three Arg residues.	Arginine	287-290	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	243-249
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	protein arginine N-methyltransferase 1	Mus musculus	17-22
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	signal transducer and activator of transcription 5A	Mus musculus	169-174
30026744-11	2018	Anti-dsDNA hybridomas generated from double-deficient mice show significantly elevated numbers of arginines in the CDR3 regions of the heavy-chain as well as clonal expansions and diversification of B cell clones with moderate numbers of somatic mutations.	Arginine	98-107	cerebellar degeneration-related 3	Mus musculus	115-119
29743242-6	2018	Arginine triad substitutions that disrupted CDK9/CycT1 assembly accumulated Thr-186-dephosphorylated CDK9 associated with the cytoplasmic Hsp90/Cdc37 chaperone.	Arginine	0-8	heat shock protein 90 alpha family class A member 1	Homo sapiens	138-143
29743236-0	2018	IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53.	Arginine	5-8	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
29920217-0	2018	Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation.	Arginine	53-61	dual specificity phosphatase 14	Homo sapiens	13-19
25582476-10	2014	Sequence analysis of PDHA1 gene showed a G&gt;A point mutation at nucleotide 778, resulting in a substitution of glutarnine for arginine at position 263 (R263Q).	Arginine	128-136	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	21-26
29920217-4	2018	DUSP14 is methylated by PRMT5 at arginine 17, 38, and 45 residues.	Arginine	33-41	dual specificity phosphatase 14	Homo sapiens	0-6
29920217-5	2018	The DUSP14 triple-methylation mutant was impaired in PRMT5-mediated arginine methylation, TRAF2-mediated lysine ubiquitination, and DUSP14 phosphatase activity.	Arginine	68-76	dual specificity phosphatase 14	Homo sapiens	4-10
29920217-8	2018	Together, these findings reveal a novel regulatory mechanism of DUSP14 by which PRMT5-mediated arginine methylation may sequentially stimulate TRAF2-mediated DUSP14 ubiquitination and phosphatase activity, leading to inhibition of TCR signaling.-Yang, C.-Y., Chiu, L.-L., Chang, C.-C., Chuang, H.-C., Tan, T.-H.	Arginine	95-103	dual specificity phosphatase 14	Homo sapiens	64-70
29920217-8	2018	Together, these findings reveal a novel regulatory mechanism of DUSP14 by which PRMT5-mediated arginine methylation may sequentially stimulate TRAF2-mediated DUSP14 ubiquitination and phosphatase activity, leading to inhibition of TCR signaling.-Yang, C.-Y., Chiu, L.-L., Chang, C.-C., Chuang, H.-C., Tan, T.-H.	Arginine	95-103	dual specificity phosphatase 14	Homo sapiens	158-164
29920217-9	2018	Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation.	Arginine	53-61	dual specificity phosphatase 14	Homo sapiens	13-19
29597093-2	2018	Regarding the important role of arginine (Arg) in the regulation of multiple metabolic and signaling pathways, its deprivation has been proposed as a good strategy for tumor regression in tumors with defected Arg metabolic enzymes like argininosuccinate synthase 1 (ASS1).	Arginine	32-40	argininosuccinate synthase 1	Homo sapiens	236-264
25310961-14	2014	A significant effect of interaction of carrying both IRS-1 Gly/Arg and IRS-2 Asp/Asp was also observed in the non-obese PCOS patients (p = 0.003), but not in the obese PCOS patients.	Arginine	63-66	insulin receptor substrate 1	Homo sapiens	53-58
29597093-2	2018	Regarding the important role of arginine (Arg) in the regulation of multiple metabolic and signaling pathways, its deprivation has been proposed as a good strategy for tumor regression in tumors with defected Arg metabolic enzymes like argininosuccinate synthase 1 (ASS1).	Arginine	32-40	argininosuccinate synthase 1	Homo sapiens	266-270
29674316-8	2018	Sequence deletions encompassing Thr-6, Phe-7, or Arg-8 in barttin completely failed to activate hClC-Ka.	Arginine	49-52	barttin CLCNK type accessory subunit beta	Homo sapiens	58-65
24993872-9	2014	The mutation, confirmed by 3 orthogonal methods, alters an evolutionarily conserved region of the HMGB3 protein from a negatively charged polyglutamic acid tract to a positively charged arginine-rich motif that is likely to interfere with normal protein function.	Arginine	186-194	high mobility group box 3	Homo sapiens	98-103
28462680-6	2018	MDSC immunosuppression involves reduction of arginine levels, which leads to downregulation of T-cell receptor (TCR) and cell proliferation.	Arginine	45-53	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	95-110
25229620-6	2014	In the present study, we expressed and purified recombinant human endostatin (rhEndostatin) that contained 3 additional amino acid residues (arginine, glycine, and serine) at the amino-terminus and 6 histidine residues in its carboxyl terminus.	Arginine	141-149	collagen type XVIII alpha 1 chain	Homo sapiens	66-76
28462680-6	2018	MDSC immunosuppression involves reduction of arginine levels, which leads to downregulation of T-cell receptor (TCR) and cell proliferation.	Arginine	45-53	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	112-115
25041756-2	2014	Our previous studies show that abnormal uptake of the nitric oxide precursor L-arginine, via the cationic amino acid transporter-1 (CAT1), contributes to endothelial dysfunction in cardiovascular disease.	Arginine	77-87	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	97-130
29501008-6	2018	In addition, we observed increased AMPK phosphorylation at Thr172 and SIRT3 levels in nutrient restricted ewes, and these effects decreased with arginine treatment.	Arginine	145-153	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Ovis aries	70-75
25041756-2	2014	Our previous studies show that abnormal uptake of the nitric oxide precursor L-arginine, via the cationic amino acid transporter-1 (CAT1), contributes to endothelial dysfunction in cardiovascular disease.	Arginine	77-87	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	132-136
29626083-4	2018	We identified three conserved arginine residues in Tra1 that reside proximal or within the cleft between the N- and C-terminal subdomains of the PI3K domain.	Arginine	30-38	histone acetyltransferase TRA1	Saccharomyces cerevisiae S288C	51-55
25125176-1	2014	Posttranslational addition of Arg to proteins, mediated by arginyltransferase ATE1 has been first observed in 1963 and remained poorly understood for decades since its original discovery.	Arginine	30-33	arginyltransferase 1	Homo sapiens	78-82
29626083-5	2018	To establish a function for Tra1"s PI3K domain and specifically the cleft region, we characterized a tra1 allele where these three arginine residues are mutated to glutamine.	Arginine	131-139	histone acetyltransferase TRA1	Saccharomyces cerevisiae S288C	28-32
29626083-5	2018	To establish a function for Tra1"s PI3K domain and specifically the cleft region, we characterized a tra1 allele where these three arginine residues are mutated to glutamine.	Arginine	131-139	histone acetyltransferase TRA1	Saccharomyces cerevisiae S288C	101-105
25024404-5	2014	Structure-function analysis revealed that the arginine/serine-rich motif and the C-terminal zinc finger domain required for speckle localization are necessary for the adipocyte differentiation function of ZNF638 and for the regulation of the levels of alternatively spliced isoforms of lipin1 and nuclear receptor co-repressor 1.	Arginine	46-54	lipin 1	Homo sapiens	286-328
29486334-13	2018	Brain nitrite content was enhanced although eNOS, NFkappaB levels, and AChE activity was decimated by L-Arginine treatment.	Arginine	102-112	acetylcholinesterase	Rattus norvegicus	71-75
25164070-1	2014	BACKGROUND: Many advanced human tumors, including hepatocellular carcinomas (HCC) are auxotrophic for arginine due to down-regulation of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in arginine synthesis.	Arginine	102-110	argininosuccinate synthase 1	Homo sapiens	167-171
29459713-8	2018	SLC25A29-knockout cells dramatically altered the variation of metabolic processes, whereas addition of arginine failed to reverse the effect, highlighting the necessity of transporting arginine into mitochondria by SLC25A29.	Arginine	185-193	solute carrier family 25 member 29	Homo sapiens	0-8
25024265-1	2014	Missense mutations at arginine residues in the S4 voltage-sensor domains of NaV1.4 are an established cause of hypokalemic periodic paralysis, an inherited disorder of skeletal muscle involving recurrent episodes of weakness in conjunction with low serum K(+).	Arginine	22-30	sodium voltage-gated channel alpha subunit 4	Homo sapiens	76-82
29459713-8	2018	SLC25A29-knockout cells dramatically altered the variation of metabolic processes, whereas addition of arginine failed to reverse the effect, highlighting the necessity of transporting arginine into mitochondria by SLC25A29.	Arginine	185-193	solute carrier family 25 member 29	Homo sapiens	215-223
29459713-9	2018	In conclusion, aberrant elevated SLC25A29 in cancer functioned to transport more arginine into mitochondria, improved mitochondria-derived NO levels, thus modulated metabolic status to facilitate increased cancer progression.	Arginine	81-89	solute carrier family 25 member 29	Homo sapiens	33-41
24907272-0	2014	An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.	Arginine	3-11	ring finger protein 4	Homo sapiens	26-47
24907272-0	2014	An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Kruppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.	Arginine	3-11	ring finger protein 4	Homo sapiens	49-53
29908641-12	2018	These findings provide fundamental information regarding placental PRMT1-mediated arginine methylation during the development.	Arginine	82-90	protein arginine N-methyltransferase 1	Mus musculus	67-72
29121483-10	2018	Thus, high concentrations of NCG (1.0mM) and ARG (4.0mM) may act both directly and indirectly to regulate GnRH neuron function by downregulating genes related to GnRH synthesis and secretion to slow GnRH production while stimulating GT1-7 cell proliferation.	Arginine	45-48	gonadotropin releasing hormone 1	Mus musculus	162-166
24907272-4	2014	Besides the SUMO interacting motif (SIM), a previously unrecognized, but evolutionarily conserved, arginine-rich motif (ARM) in RNF4 acts as a novel recognition motif for selective target recruitment.	Arginine	99-107	ring finger protein 4	Homo sapiens	128-132
29121483-10	2018	Thus, high concentrations of NCG (1.0mM) and ARG (4.0mM) may act both directly and indirectly to regulate GnRH neuron function by downregulating genes related to GnRH synthesis and secretion to slow GnRH production while stimulating GT1-7 cell proliferation.	Arginine	45-48	gonadotropin releasing hormone 1	Mus musculus	162-166
29540477-4	2018	We show that CHCHD10 copurifies with cytochrome c oxidase (COX) and up-regulates COX activity by serving as a scaffolding protein required for MNRR1 phosphorylation, mediated by ARG (ABL proto-oncogene 2, nonreceptor tyrosine kinase (ABL2)).	Arginine	178-181	coiled-coil-helix-coiled-coil-helix domain containing 10	Homo sapiens	13-20
24375788-0	2014	In vivo analysis of Arg-Gly-Asp sequence/integrin alpha5beta1-mediated signal involvement in embryonic enchondral ossification by exo utero development system.	Arginine	20-23	5'-3' exoribonuclease 1	Mus musculus	130-133
24375788-3	2014	The purpose of this study is to elucidate in vivo the roles of the integrin alpha5beta1-mediated signal through the Arg-Gly-Asp (RGD) sequence in the cell-extracellular matrix (ECM) interaction in embryonic enchondral ossification by an exo utero development system.	Arginine	116-119	5'-3' exoribonuclease 1	Mus musculus	237-240
29540477-4	2018	We show that CHCHD10 copurifies with cytochrome c oxidase (COX) and up-regulates COX activity by serving as a scaffolding protein required for MNRR1 phosphorylation, mediated by ARG (ABL proto-oncogene 2, nonreceptor tyrosine kinase (ABL2)).	Arginine	178-181	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	183-232
29540477-4	2018	We show that CHCHD10 copurifies with cytochrome c oxidase (COX) and up-regulates COX activity by serving as a scaffolding protein required for MNRR1 phosphorylation, mediated by ARG (ABL proto-oncogene 2, nonreceptor tyrosine kinase (ABL2)).	Arginine	178-181	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	234-238
29765542-4	2018	However, substitution mutation (Arginine and Lysine to Alanine) in the D-box elements of SMAR1 viz.	Arginine	32-40	BTG3 associated nuclear protein	Mus musculus	89-94
24757983-1	2014	The present research work describes the formulation of arginine conjugated 3.0G Poly(propylene) imine (PPI) dendrimers, mimicking the surface structure of an endogenous angiogenesis-inhibitor endostatin; for tumor specific delivery of a model anticancer drug, doxorubicin hydrochloride (Dox).	Arginine	55-63	collagen type XVIII alpha 1 chain	Homo sapiens	192-202
29624498-5	2018	We demonstrate that arginine-to-lysine substitutions conferring an increased sensitivity to TRIM22-dependent ubiquitination accumulated progressively in the NP of seasonal influenza A (H1N1) viruses between 1918 and 2009.	Arginine	20-28	tripartite motif containing 22	Homo sapiens	92-98
24940753-0	2014	Cannabinoid receptor 2-63 QQ variant is associated with persistently normal aminotransferase serum levels in chronic hepatitis C. BACKGROUND AND AIM: To evaluate in anti-HCV-positive patients the clinical impact of the rs35761398 variant of the CNR2 gene leading to the substitution of Gln (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with Arg (R).	Arginine	347-350	cannabinoid receptor 2	Homo sapiens	0-22
29624498-7	2018	We show that four arginine residues present in the NP of the 1918 H1N1 pandemic strain and early postpandemic strains were progressively substituted for by lysines between 1918 and 2009, rendering NP more susceptible to TRIM22-mediated ubiquitination.	Arginine	18-26	tripartite motif containing 22	Homo sapiens	220-226
29462789-6	2018	hFEN1 residues with distinct roles in the catalytic mechanism, including those binding metal ions (Asp-34 and Asp-181), steering the 5"-flap through the active site and binding the scissile phosphate (Lys-93 and Arg-100), and stacking against the base 5" to the scissile phosphate (Tyr-40), all contribute to these rate-limiting conformational changes, ensuring efficient and specific cleavage of 5"-flaps.	Arginine	212-215	flap structure-specific endonuclease 1	Homo sapiens	0-5
24622397-2	2014	The presence of unusual acidic amino acid patches at the N-terminal end of dBigH1 is in contrast to the arginine patches that exist at the N- and C-terminal domains of other histone H1-related proteins found in the sperm of some organisms.	Arginine	104-112	Histone H1 variant BigH1	Drosophila melanogaster	75-81
29564399-0	2018	Dal81 Regulates Expression of Arginine Metabolism Genes in Candida parapsilosis.	Arginine	30-38	Dal81p	Saccharomyces cerevisiae S288C	0-5
24768535-7	2014	However, ISGylation-defective Lys-to-Arg mutations in PCNA or knockdown of any of ISG15, EFP, or USP10 led to persistent recruitment of mono-ubiquitinated PCNA and polymerase-eta to nuclear foci, causing an increase in mutation frequency.	Arginine	37-40	proliferating cell nuclear antigen	Homo sapiens	54-58
24768535-7	2014	However, ISGylation-defective Lys-to-Arg mutations in PCNA or knockdown of any of ISG15, EFP, or USP10 led to persistent recruitment of mono-ubiquitinated PCNA and polymerase-eta to nuclear foci, causing an increase in mutation frequency.	Arginine	37-40	proliferating cell nuclear antigen	Homo sapiens	155-159
29721066-1	2018	Rational: In a subset of cancers, arginine auxotrophy occurs due to the loss of expression of argininosuccinate synthetase 1 (ASS1).	Arginine	34-42	argininosuccinate synthase 1	Homo sapiens	126-130
24613676-7	2014	On the other hand, glyoxal modifies Lys-133 and Lys-145 to carboxymethyllysine and Arg-31 to hydroimidazolone adducts in myoglobin.	Arginine	83-86	myoglobin	Homo sapiens	121-130
29721066-2	2018	This loss of ASS1 expression makes cancers sensitive to arginine starvation that is induced by PEGylated arginine deiminase (ADI-PEG20).	Arginine	56-64	argininosuccinate synthase 1	Homo sapiens	13-17
24615730-1	2014	BACKGROUND: Carboxypeptidase-D (CPD) cleaves C-terminal arginine for nitric oxide (NO) production.	Arginine	56-64	carboxypeptidase D	Homo sapiens	12-30
29180282-6	2018	Of the 82 isolates, 51 (62%) showed an increase in the number of copies of the respective ARG in the phage fraction following induction, with blaTEM, blaCTX-M-1 group, blaCTX-M-9 group and sul1 being the most abundant.	Arginine	90-93	Sul1	Klebsiella pneumoniae	189-193
24384368-5	2014	The phenotype of nuclear envelope-linked lipodystrophies ranges from the typical familial partial lipodystrophy of the Dunnigan type (FPLD2), due to heterozygous substitutions of the 482nd arginine of lamins A/C, to complex diseases that can combine lipodystrophy, metabolic complications, muscular or cardiac alterations and/or signs of accelerated aging.	Arginine	189-197	lamin A/C	Homo sapiens	134-139
29432156-9	2018	Mutation of lysine residues to arginines in the N-terminal region of BubR1 partially inhibited its ubiquitylation and slowed down the release of MCC from APC/C, provided that Cdc20 ubiquitylation was also blocked.	Arginine	31-40	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	69-74
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	55-58	ETS proto-oncogene 1, transcription factor	Homo sapiens	168-172
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	ETS proto-oncogene 1, transcription factor	Homo sapiens	168-172
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	interleukin 1, beta	Gallus gallus	66-74
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	ETS proto-oncogene 1, transcription factor	Homo sapiens	50-54
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	toll like receptor 4	Gallus gallus	76-96
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	toll like receptor 4	Gallus gallus	98-102
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	ETS proto-oncogene 1, transcription factor	Homo sapiens	216-220
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	interleukin 1, beta	Gallus gallus	142-150
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	interleukin 10	Gallus gallus	152-157
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	177-180	ETS proto-oncogene 1, transcription factor	Homo sapiens	50-54
24330949-7	2014	Arginine supplementation decreased (P&lt; 0.05) the expression of IL-1beta, Toll-like receptor 4 (TLR4) and PPAR-gamma mRNA in the spleen and IL-1beta, IL-10, TLR4 and NF-kappaB mRNA in the caecal tonsils.	Arginine	0-8	toll like receptor 4	Gallus gallus	159-163
24330949-9	2014	Collectively, Arg supplementation attenuated the overexpression of pro-inflammatory cytokines probably through the suppression of the TLR4 pathway and CD14+ cell percentage.	Arginine	14-17	toll like receptor 4	Gallus gallus	134-138
29434246-5	2018	ADAMTS13 exhibited a general preference for aliphatic amino acids throughout the P3-P3" interval, except at P2 where Arg was tolerated.	Arginine	117-120	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	0-8
24648395-2	2014	However, metabolism of arginine to agmatine via arginine decarboxylase (ADC) and conversion of agmatine to polyamines via agmatinase (AGMAT) is an alternative pathway long recognized in lower organisms, but only recently suggested for neurons and liver cells of mammals.	Arginine	23-31	antizyme inhibitor 2	Homo sapiens	48-70
29422017-2	2018	However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1).	Arginine	55-63	argininosuccinate synthase 1	Homo sapiens	171-175
29422017-9	2018	RESULTS: Orthogonal partial least squares-discriminant analysis (OPLS-DA) of both the 1D and 2D GC-TOFMS data revealed significant systematic difference in metabolites between the two subgroups with ASS1 positive cells generally exhibiting an overall elevation of identified metabolites, including those involved in the arginine biosynthetic pathway.	Arginine	320-328	argininosuccinate synthase 1	Homo sapiens	199-203
29422017-10	2018	Pathway and network analysis of the metabolite profile show that ASS1 negative cells have altered arginine and citrulline metabolism as well as altered amino acid metabolism.	Arginine	98-106	argininosuccinate synthase 1	Homo sapiens	65-69
29286644-4	2018	In this work, we showed that arginine-substituted alpha-Syn ligands, based on the most aggregation-prone sequence of alpha-Syn, accelerate the protein aggregation in a concentration-dependent manner.	Arginine	29-37	synuclein alpha	Homo sapiens	50-59
29286644-4	2018	In this work, we showed that arginine-substituted alpha-Syn ligands, based on the most aggregation-prone sequence of alpha-Syn, accelerate the protein aggregation in a concentration-dependent manner.	Arginine	29-37	synuclein alpha	Homo sapiens	117-126
29286644-5	2018	To elucidate the mechanism by which Arg-substituted peptides could modulate alpha-Syn aggregation kinetics, we performed surface plasmon resonance (SPR) spectroscopy, nuclear magnetic resonance (NMR) studies, and all-atom molecular dynamics (MD) simulation.	Arginine	36-39	synuclein alpha	Homo sapiens	76-85
29286644-7	2018	The two-dimensional NMR studies suggest that a large stretch within the C-terminus of alpha-Syn displays a chemical shift perturbation upon interacting with Arg-substituted peptides, indicating C-terminal residues of alpha-Syn might be responsible for this class of peptide binding.	Arginine	157-160	synuclein alpha	Homo sapiens	86-95
29286644-7	2018	The two-dimensional NMR studies suggest that a large stretch within the C-terminus of alpha-Syn displays a chemical shift perturbation upon interacting with Arg-substituted peptides, indicating C-terminal residues of alpha-Syn might be responsible for this class of peptide binding.	Arginine	157-160	synuclein alpha	Homo sapiens	217-226
29286644-8	2018	This is further supported by MD simulation studies in which the Arg-substituted peptide showed the strongest interaction with the C-terminus of alpha-Syn.	Arginine	64-67	synuclein alpha	Homo sapiens	144-153
29286644-9	2018	Overall, our results suggest that the binding of Arg-substituted ligands to the highly acidic C-terminus of alpha-Syn leads to reduced charge density and flexibility, resulting in accelerated aggregation kinetics.	Arginine	49-52	synuclein alpha	Homo sapiens	108-117
28783993-8	2018	A missense mutation in the codon 64 of the Beta-3 adrenergic receptor (ADRB3), Trp64Arg, leads to the substitution of tryptophan by arginine in the first intracellular loop of the ADRB3 receptor.	Arginine	132-140	adrenoceptor beta 3	Homo sapiens	43-69
28783993-8	2018	A missense mutation in the codon 64 of the Beta-3 adrenergic receptor (ADRB3), Trp64Arg, leads to the substitution of tryptophan by arginine in the first intracellular loop of the ADRB3 receptor.	Arginine	132-140	adrenoceptor beta 3	Homo sapiens	71-76
28783993-8	2018	A missense mutation in the codon 64 of the Beta-3 adrenergic receptor (ADRB3), Trp64Arg, leads to the substitution of tryptophan by arginine in the first intracellular loop of the ADRB3 receptor.	Arginine	132-140	adrenoceptor beta 3	Homo sapiens	180-185
29276085-6	2018	Importantly, the CFIm activator functions are mediated by the arginine-serine repeat (RS) domains of CFIm68/59, which bind specifically to an RS-like region in the CPSF subunit Fip1, and this interaction is inhibited by CFIm68/59 hyper-phosphorylation.	Arginine	62-70	cleavage and polyadenylation specific factor 6	Homo sapiens	17-21
29276085-6	2018	Importantly, the CFIm activator functions are mediated by the arginine-serine repeat (RS) domains of CFIm68/59, which bind specifically to an RS-like region in the CPSF subunit Fip1, and this interaction is inhibited by CFIm68/59 hyper-phosphorylation.	Arginine	62-70	cleavage and polyadenylation specific factor 6	Homo sapiens	101-107
29276085-6	2018	Importantly, the CFIm activator functions are mediated by the arginine-serine repeat (RS) domains of CFIm68/59, which bind specifically to an RS-like region in the CPSF subunit Fip1, and this interaction is inhibited by CFIm68/59 hyper-phosphorylation.	Arginine	62-70	cleavage and polyadenylation specific factor 6	Homo sapiens	220-226
29976090-8	2018	By forming a complex with PARK7 (and possibly misfolded protein cargoes), R-HSPA5 binds SQSTM1 through its Nt-Arg, facilitating self-polymerization of SQSTM1 and the targeting of SQSTM1-cargo complexes to phagophores.	Arginine	110-113	Parkinsonism associated deglycase	Homo sapiens	26-31
30198795-9	2018	Arginine and ADMA rose at P7 in the L-Cit group whose members also showed higher VEGF levels with respect to the Controls.	Arginine	0-8	vascular endothelial growth factor A	Rattus norvegicus	81-85
28668996-7	2018	Food with 20 mM L-arginine promoted lower protein thiol concentrations and higher catalase activity in flies of both sexes and higher concentrations of low molecular mass thiols in males.	Arginine	16-26	Catalase	Drosophila melanogaster	82-90
28668996-8	2018	When flies were fed on a diet with 100 mM L-arginine, lower catalase activities and concentrations of protein thiols were found in both sexes as well as lower low molecular mass thiols in females.	Arginine	42-52	Catalase	Drosophila melanogaster	60-68
29683372-1	2018	Chtop binds competitively to the arginine methyltransferases PRMT1 and PRMT5, thereby promoting the asymmetric or symmetric methylation of arginine residues, respectively.	Arginine	33-41	chromatin target of PRMT1	Homo sapiens	0-5
28820066-12	2017	Exceptionally several Arg residues from MT_IL27 appeared to play a major role, thereby stabilizing the simulated MT_IL27-gp130 complexes.	Arginine	22-25	interleukin 6 cytokine family signal transducer	Homo sapiens	121-126
28972166-6	2017	Our findings reveal that JMJD6 is a novel SG component that interacts with G3BP1 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Arg residues.	Arginine	179-182	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	25-30
28448789-2	2017	Secreted phosphoprotein 1 (SPP1) is increased within the uterine milieu during early porcine pregnancy and contains an Arg-Gly-Asp (RGD) peptide sequence that binds to cell surface integrins on the uterine endometrium and trophectoderm, promoting cell adhesion and migration.	Arginine	119-122	secreted phosphoprotein 1	Homo sapiens	0-25
28448789-2	2017	Secreted phosphoprotein 1 (SPP1) is increased within the uterine milieu during early porcine pregnancy and contains an Arg-Gly-Asp (RGD) peptide sequence that binds to cell surface integrins on the uterine endometrium and trophectoderm, promoting cell adhesion and migration.	Arginine	119-122	secreted phosphoprotein 1	Homo sapiens	27-31
28994430-2	2017	Here, novel multifunctional zero-dimensional-two-dimensional (0D-2D) RGD-QD-MoS2 nanosheets (NSs) with excellent fluorescence, photothermal conversion, and cancer-targeting properties were successfully prepared by functionalizing single-layer MoS2 NSs with fluorescent quantum dots (QDs) and arginine-glycine-aspartic (RGD) containing peptides.	Arginine	292-300	mago homolog, exon junction complex core component	Mus musculus	76-80
29204107-2	2017	The CD13-targeting moiety NGR was synthesized and cyclized by native chemical ligation (NCL) instead of disulfide bridging, leading to a cyclic peptide backbone: cyclo(Cys-Asn-Gly-Arg-Gly) (coNGR).	Arginine	180-183	alanyl (membrane) aminopeptidase	Mus musculus	4-8
28711961-3	2017	In the present study, we sought to evaluate whether the cytoprotective effects of L-arginine in neonatal obstructive nephropathy may be associated with NO-dependent increases in WT-1 and Hsp70 expression.	Arginine	82-92	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	187-192
24566094-7	2014	Structurally, HLA-B*35:05 belonged to the HLA-B*35-PY group of HLA-B*35 alleles; however, unlike the other HLA-B*35 alleles that carry Arg (R) at residue 97, it has unique sequences at T94, L95, and S97, located within the peptide-binding groove.	Arginine	135-138	major histocompatibility complex, class I, B	Homo sapiens	14-19
28711961-8	2017	L-arginine treatment increased NO levels, reduced apoptosis and restored expression levels of WT-1 and Hsp70 to control levels.	Arginine	0-10	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	103-108
28711961-11	2017	CONCLUSIONS: L-arginine treatment in experimental neonatal UUO reduces apoptosis coincident with restoration of WT-1 and Hsp70 expression levels and directly inhibits mechanical strain-induced apoptosis in an NO-dependent manner in vitro.	Arginine	13-23	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	121-126
28711961-12	2017	This potentially implicates an NO-Hsp70-WT-1 axis in the cytoprotective effects of L-arginine.	Arginine	83-93	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	34-39
28710003-0	2017	Amelioration of atherosclerotic inflammation and plaques via endothelial adrenoceptor-targeted eNOS gene delivery using redox-sensitive polymer bearing l-arginine.	Arginine	152-162	nitric oxide synthase 3, endothelial cell	Mus musculus	95-99
24508628-6	2014	The diagnosis was confirmed by sequence analysis of the MPI gene revealing a homozygous missense mutation (c.656G&gt;A) causing replacement of arginine by glutamine (p.R219Q).	Arginine	143-151	mannose phosphate isomerase	Homo sapiens	56-59
28710003-4	2017	Overexpression of alpha-2ARs on atherosclerotic endothelial cells was confirmed and the eNOS/rsPOLA nanoplexes following systemic injection demonstrated to 1) enhance eNOS gene delivery into endothelial cells via alpha-2ARs/l-arginine specific binding, 2) increase intracellular level of nitric oxide, 3) suppress inflammatory response in endothelium and finally 4) reduce atherosclerotic plaque in a Ldlr-/- atherosclerotic mouse model.	Arginine	226-234	nitric oxide synthase 3, endothelial cell	Mus musculus	88-92
28812766-6	2017	Arginine supplementation up-regulated muscle HSP70 and HSP90 and serum HSP70, however, none of the amino acids affected the HSP25.	Arginine	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	45-50
23235339-2	2014	The most common IDH1 mutation affects codon 132 and results in the conversion of amino acid residue arginine (R) to histidine (H).	Arginine	100-108	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	16-20
24417816-8	2014	A nucleotide variation in the Oxidative Stress-Induced Growth Inhibitor 1 (OSGIN1) gene (nt 1494: G-A) resulted in an amino acid substitution (codon 438: Arg-His).	Arginine	154-157	oxidative stress induced growth inhibitor 1	Homo sapiens	30-73
24417816-8	2014	A nucleotide variation in the Oxidative Stress-Induced Growth Inhibitor 1 (OSGIN1) gene (nt 1494: G-A) resulted in an amino acid substitution (codon 438: Arg-His).	Arginine	154-157	oxidative stress induced growth inhibitor 1	Homo sapiens	75-81
28812766-6	2017	Arginine supplementation up-regulated muscle HSP70 and HSP90 and serum HSP70, however, none of the amino acids affected the HSP25.	Arginine	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	71-76
28456996-4	2017	Here, we study the inhibitory potential of a cationic polymer polyethyleneimine (PEI) and a cationic polypeptide arginine (Arg) on the aggregation of VQIVYK, and GKVQIINKLDL peptides, and tau mutant protein (P301L), found frequently in taupathy.	Arginine	123-126	microtubule associated protein tau	Homo sapiens	188-191
24651445-0	2014	L-arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway.	Arginine	0-10	G protein-coupled receptor class C group 6 member A	Homo sapiens	59-72
28456996-6	2017	Results show that PEI and Arg significantly inhibit tau peptides and protein aggregation.	Arginine	26-29	microtubule associated protein tau	Homo sapiens	52-55
28962167-0	2017	Effect of L-arginine supplementation on the hepatic phosphatidylinositol 3-kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth-restricted rats.	Arginine	10-20	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	52-81
24651445-8	2014	The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival.	Arginine	109-117	G protein-coupled receptor class C group 6 member A	Homo sapiens	61-74
28962167-1	2017	The present study aimed to investigate the response of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats to dietary L-arginine (L-Arg) supplementation during the lactation period early in life.	Arginine	190-200	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	59-88
28962167-1	2017	The present study aimed to investigate the response of the phosphatidylinositol 3-kinase (PI3K) signaling pathway and gluconeogenic enzymes in intrauterine growth-restricted rats to dietary L-arginine (L-Arg) supplementation during the lactation period early in life.	Arginine	202-207	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	59-88
28695568-5	2017	We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs.	Arginine	31-39	protein arginine N-methyltransferase 1	Mus musculus	14-19
24433040-1	2014	Plasma membrane-bound carboxypeptidase-D (CPD) cleaves C-terminal arginine from extracellular substrates.	Arginine	66-74	carboxypeptidase D	Homo sapiens	42-45
28936921-9	2017	TOV-112D and SKOV-3 cells also overexpressed hnRNP in relation to serine/arginine-rich transcripts.	Arginine	73-81	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	45-50
24344137-2	2014	Arg-453 is found in a conserved surface loop of the upper 50-kDa domain of the myosin motor domain and lies between the nucleotide binding pocket and the actin binding site.	Arginine	0-3	myosin heavy chain 14	Homo sapiens	79-85
28936921-11	2017	Our data showed that higher osteopontin-c expression levels are associated with a predominance of hnRNP in relation to serine/arginine-rich transcripts and that osteopontin exon 4 and adjacent intronic sequences contain predicted binding sites for some of these tested splicing factors.	Arginine	126-134	secreted phosphoprotein 1	Homo sapiens	28-39
28854955-4	2017	Comparative analyses of their genomic variations and proliferation characteristics identified a single mutation within the S2" cleavage site between C30 and C40 mutants: the substitution of conserved arginine (R) by a glycine (G) (R895G).	Arginine	200-208	CCR4-NOT transcription complex subunit 11	Homo sapiens	157-160
23435422-5	2014	In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR).	Arginine	195-204	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-59
23435422-5	2014	In this manuscript, we have extensively characterized a MYC signalling mutant in which six lysine residues near the highly conserved MYC homology box IV and basic region have been substituted to arginines (6KR).	Arginine	195-204	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-136
28699744-3	2017	Optimized conjugate 16 was designed so that esterase activity will liberate 5 and cathepsin K cleavage of the Leu-Arg-PABA element will liberate alendronic acid.	Arginine	114-117	cathepsin K	Homo sapiens	82-93
24269305-10	2014	At the beginning of the surgery the Arg level was significantly higher in young rats (C-2: 102.1+-35.7 mumol/l; IR-2: 114.63+-28.9 mumol/l) than in older ones (C-12: 41.88+-44.7 mumol/l; IR-12: 28.64+-30.6 mumol/l).	Arginine	36-39	complement C2	Rattus norvegicus	86-89
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Arginine	108-116	sirtuin 3	Mus musculus	39-44
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	Arginine	243-248	endothelin 1	Mus musculus	92-96
28854561-1	2017	Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival.	Arginine	8-16	WD repeat domain 77	Homo sapiens	61-83
24383758-1	2014	Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in which P2" residue Leu17 (bovine pancreatic trypsin inhibitor numbering) is mutated to Arg selectively inhibits the active site of plasmin with ~5-fold improved affinity.	Arginine	148-151	plasminogen	Bos taurus	192-199
28854561-1	2017	Protein arginine methyltransferase 5 (PRMT5) cooperates with methylosome protein 50 (MEP50) to arginine methylate histone H3 and H4 to silence gene expression, and increased PRMT5 activity is associated with enhanced cancer cell survival.	Arginine	8-16	WD repeat domain 77	Homo sapiens	85-90
28759568-1	2017	OBJECTIVE: This is the first study to analyze the impact of the rs35761398 variant of the CNR2 gene leading to the substitution of GLN (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with ARG (R) on the clinical presentation of chronic hepatitis in HIV/HCV coinfected patients.	Arginine	192-195	cannabinoid receptor 2	Homo sapiens	90-94
24333447-5	2014	A point mutation of lysine to-arginine in position 432 of COX-2 (K432R) yields an enzyme with decreased sensitivity to EP1 -mediated degradation.	Arginine	30-38	prostaglandin E receptor 1	Homo sapiens	119-122
25036121-5	2014	Consistent with these, arginine uptake into vacuolar membrane vesicles was decreased by Avt4p-, but not by Avt3p-overproduction, whereas various neutral amino acids were excreted from vacuolar membrane vesicles in a manner dependent on either Avt4p or Avt3p.	Arginine	23-31	Avt4p	Saccharomyces cerevisiae S288C	88-93
25036121-5	2014	Consistent with these, arginine uptake into vacuolar membrane vesicles was decreased by Avt4p-, but not by Avt3p-overproduction, whereas various neutral amino acids were excreted from vacuolar membrane vesicles in a manner dependent on either Avt4p or Avt3p.	Arginine	23-31	Avt4p	Saccharomyces cerevisiae S288C	243-248
28759568-1	2017	OBJECTIVE: This is the first study to analyze the impact of the rs35761398 variant of the CNR2 gene leading to the substitution of GLN (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with ARG (R) on the clinical presentation of chronic hepatitis in HIV/HCV coinfected patients.	Arginine	192-195	cannabinoid receptor 2	Homo sapiens	158-180
28759568-1	2017	OBJECTIVE: This is the first study to analyze the impact of the rs35761398 variant of the CNR2 gene leading to the substitution of GLN (Q) of codon 63 of the cannabinoid receptor 2 (CB2) with ARG (R) on the clinical presentation of chronic hepatitis in HIV/HCV coinfected patients.	Arginine	192-195	cannabinoid receptor 2	Homo sapiens	182-185
28652325-2	2017	FcepsilonR1gamma and CD247 share high sequence homology and form disulphide-linked homodimers that contain a pair of acidic aspartic acid residues in their transmembrane (TM) domains that mediate assembly, via interaction with an arginine residue at a similar register to these aspartic acids, with the activating immunoreceptors.	Arginine	230-238	CD247 molecule	Homo sapiens	0-26
28364216-1	2017	PURPOSE: Carboxypeptidase-D (CPD) cleaves C-terminal arginine (Arg) to produce nitric oxide (NO).	Arginine	53-61	carboxypeptidase D	Homo sapiens	9-27
24268404-10	2014	The bOPN fragments were shown to interact with the integrin receptor alphaVbeta3 as efficiently as the well-characterized and highly active OPN fragment Ile(1)-Arg(152), generated by thrombin cleavage of human milk OPN.	Arginine	160-163	secreted phosphoprotein 1	Homo sapiens	140-143
28364216-1	2017	PURPOSE: Carboxypeptidase-D (CPD) cleaves C-terminal arginine (Arg) to produce nitric oxide (NO).	Arginine	63-66	carboxypeptidase D	Homo sapiens	9-27
24603432-4	2014	Here, using the point-mutated HD of KN1 and shoot meristemless (STM) in the trichome rescue system, together with molecular structure modeling, we have found the evolutionarily conserved amino acid residues, such as arginine in helix alpha1 and leucine in helix alpha3, which are essential for intercellular trafficking.	Arginine	216-224	homeotic protein knotted-1	Zea mays	36-39
28447171-1	2017	A recurrent glycine-to-arginine/valine alteration at codon 34 (G34R/V) within H3F3A, a gene that encodes the replication-independent histone variant H3.3, reportedly occurs exclusively in pediatric glioblastomas.	Arginine	23-31	H3.3 histone A	Homo sapiens	78-83
28299531-5	2017	Mass spectrometric studies revealed formation of glyoxal-derived fluorescent AGE adduct pentosidine between Lys-145 and Arg-139 residues of Mb.	Arginine	120-123	myoglobin	Homo sapiens	140-142
24715966-3	2013	Protein arginine methyltransferase 7 (Prmt7) is categorized as a type II and type III enzyme that produces symmetric dimethylated arginine and monomethylated arginine, respectively.	Arginine	8-16	protein arginine N-methyltransferase 7	Mus musculus	38-43
28969007-3	2017	Arginine is a semi-essential amino acid that is imported from the extracellular microenvironment or recycled from intracellular precursors through the combined expression of the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) enzymes.	Arginine	0-8	ornithine transcarbamylase	Homo sapiens	186-212
24380022-3	2013	The ASS1 participates in urea and nitric oxide production and is a rate-limiting enzyme in arginine biosynthesis.	Arginine	91-99	argininosuccinate synthase 1	Homo sapiens	4-8
24328739-2	2013	Arginine 132 (R132) of IDH1 and arginine 172 (R172) of IDH2 are functionally important residues.	Arginine	0-8	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	55-59
24328739-2	2013	Arginine 132 (R132) of IDH1 and arginine 172 (R172) of IDH2 are functionally important residues.	Arginine	32-40	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	55-59
23993707-2	2013	Myeloid-derived suppressor cells (MDSCs) modulate T-cell responses by down-modulating the T cell receptor zeta chain (TCR zeta) through the catabolism of l-arginine.	Arginine	154-164	CD247 molecule	Homo sapiens	90-116
23993707-2	2013	Myeloid-derived suppressor cells (MDSCs) modulate T-cell responses by down-modulating the T cell receptor zeta chain (TCR zeta) through the catabolism of l-arginine.	Arginine	154-164	CD247 molecule	Homo sapiens	118-126
24089531-0	2013	NDUFAF7 methylates arginine 85 in the NDUFS2 subunit of human complex I.	Arginine	19-27	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	0-7
24089531-8	2013	In the present study, the presence of NDUFAF7 in the mitochondrial matrix has been confirmed, and it has been demonstrated that it is a protein methylase that symmetrically dimethylates the omega-N(G),N(G") atoms of residue Arg-85 in the NDUFS2 subunit of complex I.	Arginine	224-227	NADH:ubiquinone oxidoreductase complex assembly factor 7	Homo sapiens	38-45
24140420-5	2013	EPG-11/PRMT-1 directly methylates arginines in the RGG domains of PGL-1 and PGL-3.	Arginine	34-43	Guanyl-specific ribonuclease pgl-3	Caenorhabditis elegans	76-81
24095712-0	2013	Synergistic solubilization of porcine myosin in physiological salt solution by arginine.	Arginine	79-87	myosin heavy chain 14	Homo sapiens	38-44
28554203-2	2017	Inositol polyphosphate multikinase (IPMK) was first identified as a subunit of the arginine-responsive transcription complex in budding yeast.	Arginine	83-91	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-34
28554203-2	2017	Inositol polyphosphate multikinase (IPMK) was first identified as a subunit of the arginine-responsive transcription complex in budding yeast.	Arginine	83-91	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	36-40
29658670-10	2017	The immunohistochemistry and Western blot showed that the expression of VEGF in choke zone II of L-Arg group was significantly higher than that in control group (&lt;i&gt;t&lt;/i&gt;=9.428 and -3.054,&lt;i&gt;P&lt;/i&gt;&lt;0.05 or &lt;i&gt;P&lt;/i&gt;&lt;0.01).	Arginine	97-102	vascular endothelial growth factor A	Rattus norvegicus	72-76
28538181-3	2017	To investigate the mechanism mediating the effect of fumarase-related metabolites on hypertension, we considered the pathway in which L-malate can be converted to oxaloacetate, aspartate, argininosuccinate, and L-arginine, the substrate of nitric oxide (NO) synthase.	Arginine	211-221	fumarate hydratase	Rattus norvegicus	53-61
28396513-6	2017	Furthermore, there were thicker corneas, higher intraocular pressure (IOP) and a shorter axial length in patients carrying the mutant genotypes of hOGG1 Ser326Cys (Ser/Cys + Cys/Cys), APE1 Asp148Glu (Asp/Glu + Glu/Glu) and XRCC1 Arg399Gln (Arg/Gln + Glu/Glu) than those carrying the corresponding wild-type genotypes.	Arginine	229-232	8-oxoguanine DNA glycosylase	Homo sapiens	147-152
23687069-3	2013	An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg-Gly-Asp motifs.	Arginine	78-81	nuclear receptor subfamily 5 group A member 1	Homo sapiens	3-6
28083596-1	2017	Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix.	Arginine	432-440	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	0-19
24064213-7	2013	The results support the view that many self-peptides in the L(d) system (or the HLA-B system) would exhibit enhanced binding to Arg(97) alleles compared with Trp(97) alleles.	Arginine	128-131	major histocompatibility complex, class I, B	Homo sapiens	80-85
24064213-8	2013	Accordingly, the self-peptide MHC-Arg(97) complexes would influence T-cell selection behavior, impacting the T-cell repertoire of these individuals, and could also impact peripheral T cell activity through effects of self-peptide L(d) interacting with TCR and/or CD8.	Arginine	34-37	T cell receptor alpha variable 6-3	Mus musculus	252-255
28083596-1	2017	Cytochrome P450 2U1 (CYP2U1) exhibits several distinctive characteristics among the 57 human CYPs, such as its presence in almost all living organisms with a highly conserved sequence, its particular gene organization with only five exons, its major location in thymus and brain, and its protein sequence involving an unusually long N-terminal region containing 8 proline residues and an insert of about 20 amino acids containing 5 arginine residues after the transmembrane helix.	Arginine	432-440	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	21-27
28334946-3	2017	The more centrally in the transmembrane domain an arginine was located, the lower amounts of the 120 kDa precursor LDLR in the endoplasmic reticulum were observed.	Arginine	50-58	low density lipoprotein receptor	Homo sapiens	115-119
28334946-7	2017	Introducing arginines in the transmembrane domain of the LDLR also affected metalloproteinase cleavage of the ectodomain and gamma-secretase cleavage within the transmembrane domain.	Arginine	12-21	low density lipoprotein receptor	Homo sapiens	57-61
24003229-4	2013	When RTA is separated from RTB, arginine residues located at the interface are exposed to the solvent.	Arginine	32-40	MAS related GPR family member F	Homo sapiens	5-8
28414175-3	2017	NO is produced from the amino acid L-arginine by the enzyme action of nitric oxide synthase (NOS; EC 1.14.13.39).	Arginine	35-45	nitric oxide synthase	Bombyx mori	70-91
24003229-10	2013	The mutated arginines have side chains behind the active site cleft, indicating that the ribosome binding surface of RTA is on the opposite side of the surface that interacts with the SRL.	Arginine	12-21	MAS related GPR family member F	Homo sapiens	117-120
28375949-0	2017	Interferon-gamma Aggravated L-Arginine-Induced Acute Pancreatitis in Sprague-Dawley Rats and Its Possible Mechanism: Trypsinogen Activation and Autophagy Up-regulation.	Arginine	28-38	interferon gamma	Rattus norvegicus	0-16
24116191-4	2013	The structure revealed that a cluster of lysine and arginine residues forms the positively charged DNA binding surface of human cGAS, which is important for the STING-dependent immune activation.	Arginine	52-60	cyclic GMP-AMP synthase	Homo sapiens	128-132
23744402-7	2013	Using atomic force microscopy it was shown that aggregation of alpha-lactalbumin from bovine milk induced upon addition of Arg reached a state of formation of supramolecular structures of non-fibrillar species profoundly differing from those of the individual protein in type, size, and shape.	Arginine	123-126	lactalbumin alpha	Bos taurus	63-80
28375949-10	2017	CONCLUSIONS: Interferon-gamma aggravated L-arginine-induced AP in Sprague-Dawley rats and led to intracellular trypsinogen activation and inflammatory response.	Arginine	41-51	interferon gamma	Rattus norvegicus	13-29
28496412-11	2017	Further, we observed significantly higher levels of 8-OxoG and lower levels of OGG1 in ozone group which was reversed by L-arginine and promoted by L-NAME.	Arginine	121-131	8-oxoguanine DNA glycosylase	Rattus norvegicus	79-83
23860259-3	2013	The discovery that PAD4 can target both arginine and methyl-arginine for citrullination about 10years ago renewed our interest in studying this family of enzymes in gene regulation and their physiological functions.	Arginine	40-48	peptidyl arginine deiminase 4	Homo sapiens	19-23
28406400-5	2017	We establish that RNF169 binds to ubiquitylated H2A-Lys13/Lys15 in a manner that involves its canonical ubiquitin-binding helix and a pair of arginine-rich motifs that interact with the nucleosome acidic patch.	Arginine	142-150	ring finger protein 169	Homo sapiens	18-24
23690397-6	2013	Dietary supplementation of malarial-parasite-infected mice with L-arginine or L-citrulline reduced levels of ileal transcripts encoding interleukin-4 (IL-4), a key mediator of intestinal mastocytosis and macromolecular permeability.	Arginine	64-74	interleukin 4	Mus musculus	136-149
23690397-6	2013	Dietary supplementation of malarial-parasite-infected mice with L-arginine or L-citrulline reduced levels of ileal transcripts encoding interleukin-4 (IL-4), a key mediator of intestinal mastocytosis and macromolecular permeability.	Arginine	64-74	interleukin 4	Mus musculus	151-155
28890889-4	2017	The genetic analysis revealed a novel missense c.709G&gt;A mutation in exon 7 of ALDH1A3 (aldehyde dehydrogenase 1 family member A3), causing a substitution of glycine (Gly) to arginine (Arg) at residue 237.	Arginine	177-185	aldehyde dehydrogenase 1 family member A3	Homo sapiens	81-88
24130159-4	2013	GSDA belongs to the cytidine/deoxycytidylate deaminase family of proteins together with a deaminase involved in riboflavin biosynthesis, the chloroplastic tRNA adenosine deaminase Arg and a predicted tRNA-specific adenosine deaminase 2 in A. thaliana.	Arginine	180-183	Cytidine/deoxycytidylate deaminase family protein	Arabidopsis thaliana	0-4
23955153-5	2013	NleB contained an unprecedented N-acetylglucosamine (GlcNAc) transferase activity that specifically modified a conserved arginine in these death domains (Arg 235 in the TRADD death domain).	Arginine	154-157	TNFRSF1A-associated via death domain	Mus musculus	169-174
23855493-3	2013	The aim was to assess associations of omentin with systemic markers of endothelial function, namely arginine and asymmetric dimethylarginine (ADMA) and complications of portal hypertension in liver cirrhosis.	Arginine	100-108	intelectin 1	Homo sapiens	38-45
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Arginine	215-218	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	111-114
23867956-4	2013	Both 1-OHP concentration and urinary mutagenicity tested by TA98+S9 were significantly higher in individuals with EPHX1 (exon 4) Arg/Arg genotype than in individuals with other genotype.	Arginine	129-132	epoxide hydrolase 1	Homo sapiens	114-119
23867956-4	2013	Both 1-OHP concentration and urinary mutagenicity tested by TA98+S9 were significantly higher in individuals with EPHX1 (exon 4) Arg/Arg genotype than in individuals with other genotype.	Arginine	133-136	epoxide hydrolase 1	Homo sapiens	114-119
23868824-1	2013	Protein allylation and fluorophore targeting: Arginine residues of the yeast nuclear ribonucleoprotein Npl3 were extensively modified by Hmt1-catalyzed allylation reaction with allyl-SAM as the allyl group donor.	Arginine	46-54	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	137-141
23965885-1	2013	OBJECTIVE: To measure the expression of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) in liver tissue among low-birth-weight newborn rats treated with L-arginine (L-Arg) in early life, and to investigate the effect of L-Arg on insulin resistance.	Arginine	169-179	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	40-69
23965885-1	2013	OBJECTIVE: To measure the expression of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) in liver tissue among low-birth-weight newborn rats treated with L-arginine (L-Arg) in early life, and to investigate the effect of L-Arg on insulin resistance.	Arginine	181-186	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	40-69
24223382-6	2013	L-arginine significantly increased serum vascular endothelial growth factor (VEGF) concentration (353.01 +- 7.03 vs. 100.5 +- 6.61 pg/ml; P &lt; 0.05), however, did not change myocardial capillary density.	Arginine	0-10	vascular endothelial growth factor A	Rattus norvegicus	41-75
24223382-6	2013	L-arginine significantly increased serum vascular endothelial growth factor (VEGF) concentration (353.01 +- 7.03 vs. 100.5 +- 6.61 pg/ml; P &lt; 0.05), however, did not change myocardial capillary density.	Arginine	0-10	vascular endothelial growth factor A	Rattus norvegicus	77-81
23886400-5	2013	Furthermore, the BRRS family, carrier of the c.406 T- &gt; C; p.136Cys- &gt; Arg mutation, shows a substantial alteration of PTEN protein expression that well correlates with intra-familial phenotypic variability.	Arginine	77-80	phosphatase and tensin homolog	Homo sapiens	125-129
23818587-1	2013	Peptidylarginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that converts arginine and methylarginine residues to citrulline, with histone proteins being among its best-described substrates to date.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
23714778-4	2013	Tdrkh partners with Miwi and Miwi2 via symmetrically dimethylated arginine residues in Miwi and Miwi2.	Arginine	66-74	piwi like RNA-mediated gene silencing 4	Homo sapiens	29-34
23714778-4	2013	Tdrkh partners with Miwi and Miwi2 via symmetrically dimethylated arginine residues in Miwi and Miwi2.	Arginine	66-74	piwi like RNA-mediated gene silencing 4	Homo sapiens	96-101
23796461-1	2013	Heterozygous mutations in catalytic arginine residues of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are common in glioma, acute myeloid leukemia, chondrosarcoma, cholangiocarcinoma, and angioimmunoblastic T-cell lymphoma.	Arginine	36-44	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	92-96
23562678-1	2013	An Arg-Gly-Asp (RGD) motif in the fourth FAS1 domain of the human BIGH3 (transforming growth factor-beta1-inducible gene-h3) protein has been reported to play an important role in mediating tumor angiogenesis.	Arginine	3-6	Fas cell surface death receptor	Homo sapiens	41-45
23435265-6	2013	Compared with NRG, ARG showed significantly high serum levels of KIM-1 on day 0 (pre-KTx) and on the 1st, 4th, and 7th post-KTx days, and significantly high OPN levels on day 0 and the 7th day.	Arginine	19-22	secreted phosphoprotein 1	Homo sapiens	157-160
23768406-6	2013	By means of random mutagenesis in combination with site-directed mutagenesis based on crystallographic studies of the Escherichia coli arginine/agmatine antiporter AdiC, we identified 15 amino acid residues in the Tat2 transmembrane domains (TMDs) 1, -3, -5, -8, and -10, which are responsible for tryptophan uptake.	Arginine	135-143	aromatic amino acid transmembrane transporter TAT2	Saccharomyces cerevisiae S288C	214-218
23798729-5	2013	A major isoform in immune cells, Drp1-x01 required oligomeric assembly and Arg residues in alternative exon 3 for microtubule targeting.	Arginine	75-78	dynamin 1 like	Homo sapiens	33-37
23613326-5	2013	Altogether these observations support a role of ACTA2 in brain development, especially related to the arginine at position 179.	Arginine	102-110	actin alpha 2, smooth muscle	Homo sapiens	48-53
23625379-5	2013	Intra-CA1 administration of either L-arginine (1 and 1.5 mug/0.5 mul, bilaterally) or L-NAME (at 60 ng/0.5 mul, bilaterally) decreased %OAT, which represents an anxiogenic-like effect.	Arginine	35-45	carbonic anhydrase 1	Mus musculus	6-9
23296385-6	2013	We found that P493-6 cells with High Myc expression increased their specific uptake of glutamine, arginine, serine, lysine, and branched-chain amino acids by two- to threefold in comparison to low Myc cells, but exhibited only modest increases in glucose uptake and lactate excretion.	Arginine	98-106	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-40
28890889-4	2017	The genetic analysis revealed a novel missense c.709G&gt;A mutation in exon 7 of ALDH1A3 (aldehyde dehydrogenase 1 family member A3), causing a substitution of glycine (Gly) to arginine (Arg) at residue 237.	Arginine	177-185	aldehyde dehydrogenase 1 family member A3	Homo sapiens	90-131
28890889-4	2017	The genetic analysis revealed a novel missense c.709G&gt;A mutation in exon 7 of ALDH1A3 (aldehyde dehydrogenase 1 family member A3), causing a substitution of glycine (Gly) to arginine (Arg) at residue 237.	Arginine	187-190	aldehyde dehydrogenase 1 family member A3	Homo sapiens	81-88
28890889-4	2017	The genetic analysis revealed a novel missense c.709G&gt;A mutation in exon 7 of ALDH1A3 (aldehyde dehydrogenase 1 family member A3), causing a substitution of glycine (Gly) to arginine (Arg) at residue 237.	Arginine	187-190	aldehyde dehydrogenase 1 family member A3	Homo sapiens	90-131
28454448-8	2017	Furthermore, an immunofluorescence staining assay demonstrated that the substitution of arginine with glutamine resulted in a change in the sub-cellular localization of the GNAQ recombinant protein in vitro.	Arginine	88-96	G protein subunit alpha q	Homo sapiens	173-177
23581397-6	2013	METHODS: Plasma-derived AT was chemically modified with 2,3 butanedione, a diketone known to specifically react with the arginine side chain.	Arginine	121-129	serpin family C member 1	Homo sapiens	24-26
23589299-7	2013	Furthermore, misinsertion of arginine in place of Sec was commonly observed in GPx1 and glutathione peroxidase 4.	Arginine	29-37	glutathione peroxidase 4	Homo sapiens	88-112
23589305-7	2013	We further show that KDM4B is ubiquitinated on lysines 337 and 562; simultaneous substitution of these residues to arginine suppressed the geldanamycin-induced degradation of KDM4B, suggesting that the ubiquitination of Lys-337 and Lys-562 targets KDM4B for proteasomal degradation upon Hsp90 inhibition.	Arginine	115-123	heat shock protein 90 alpha family class A member 1	Homo sapiens	287-292
23511633-0	2013	Two conserved arginine residues from the SK3 potassium channel outer vestibule control selectivity of recognition by scorpion toxins.	Arginine	14-22	potassium calcium-activated channel subfamily N member 3	Homo sapiens	41-44
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	83-91	potassium calcium-activated channel subfamily N member 3	Homo sapiens	132-135
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	83-91	potassium calcium-activated channel subfamily N member 3	Homo sapiens	196-199
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	102-105	potassium calcium-activated channel subfamily N member 3	Homo sapiens	132-135
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	102-105	potassium calcium-activated channel subfamily N member 3	Homo sapiens	196-199
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	114-117	potassium calcium-activated channel subfamily N member 3	Homo sapiens	132-135
23511633-4	2013	In this work, we demonstrate the key role of the electric charges of two conserved arginine residues (Arg-485 and Arg-489) from the SK3 channel outer vestibule in the selective recognition by the SK3-blocking BmP05 toxin.	Arginine	114-117	potassium calcium-activated channel subfamily N member 3	Homo sapiens	196-199
23511633-6	2013	In contrast, when Arg-485 or Arg-489 of the SK3 channel was mutated to an acidic (Glu) or alcoholic (Ser) amino acid residue, the channel lost its sensitivity to BmP05 and became susceptible to the "new" blocking activity by charybdotoxin.	Arginine	18-21	potassium calcium-activated channel subfamily N member 3	Homo sapiens	44-47
23511633-6	2013	In contrast, when Arg-485 or Arg-489 of the SK3 channel was mutated to an acidic (Glu) or alcoholic (Ser) amino acid residue, the channel lost its sensitivity to BmP05 and became susceptible to the "new" blocking activity by charybdotoxin.	Arginine	29-32	potassium calcium-activated channel subfamily N member 3	Homo sapiens	44-47
23511633-8	2013	Furthermore, molecular modeling data indicate the existence of a compact SK3 channel turret conformation (like a peptide screener), where the basic rings of Arg-485 and Arg-489 are stabilized by strong ionic interactions with Asp-492 and Asp-518.	Arginine	157-160	potassium calcium-activated channel subfamily N member 3	Homo sapiens	73-76
23511633-8	2013	Furthermore, molecular modeling data indicate the existence of a compact SK3 channel turret conformation (like a peptide screener), where the basic rings of Arg-485 and Arg-489 are stabilized by strong ionic interactions with Asp-492 and Asp-518.	Arginine	169-172	potassium calcium-activated channel subfamily N member 3	Homo sapiens	73-76
23511633-9	2013	In conclusion, the unique properties of Arg-485 and Arg-489 (spatial orientations and molecular interactions) in the SK3 channel account for its toxin sensitivity profile.	Arginine	40-43	potassium calcium-activated channel subfamily N member 3	Homo sapiens	117-120
23511633-9	2013	In conclusion, the unique properties of Arg-485 and Arg-489 (spatial orientations and molecular interactions) in the SK3 channel account for its toxin sensitivity profile.	Arginine	52-55	potassium calcium-activated channel subfamily N member 3	Homo sapiens	117-120
23357641-1	2013	Nephronectin is a basement membrane protein comprising five N-terminal epidermal growth factor (EGF)-like repeats, a central linker segment containing an Arg-Gly-Asp (RGD) motif and a C-terminal meprin-A5 protein-receptor protein tyrosine phosphatase mu (MAM) domain.	Arginine	154-157	nephronectin	Mus musculus	0-12
23509291-6	2013	One of the Arg residues is in the region corresponding to the "safety belt" conformational switch of Mad2, suggesting conformational regulation of phosphate binding.	Arginine	11-14	mitotic arrest deficient 2 like 1	Homo sapiens	101-105
23372161-10	2013	We constructed a series of mutants by replacing single or double Arg residues in the corin propeptide and identified Arg-530 in the Fz2 domain as the alternative autocleavage site.	Arginine	117-120	frizzled class receptor 2	Homo sapiens	132-135
23401322-0	2013	Probing arginine side-chains and their dynamics with carbon-detected NMR spectroscopy: application to the 42 kDa human histone deacetylase 8 at high pH.	Arginine	8-16	histone deacetylase 8	Homo sapiens	119-140
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	136-144	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	191-195
23376717-2	2013	IDH1/2 mutations are early and frequent genetic alterations, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1 and Arginine 172 (R172) in IDH2.	Arginine	168-176	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	191-195
23678547-2	2013	Lawsone and methylprednisolone treatments significantly attenuated the L-arginine- induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6 and significantly lowered pancreatic levels of MPO, TBARS, and nitrate/nitrite.	Arginine	71-81	myeloperoxidase	Rattus norvegicus	269-272
23329845-7	2013	In addition, we show that Lys-78 and Arg-79 are critical for the binding of ILKAP to importin alpha.	Arginine	37-40	ILK associated serine/threonine phosphatase	Homo sapiens	76-81
23269789-0	2013	Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I.	Arginine	92-100	interferon induced with helicase C domain 1	Homo sapiens	115-119
23279110-6	2013	The absence of arginine methylation in a basic region N-terminal to the PY-core motif of Pab2 did not affect its nuclear localization.	Arginine	15-23	poly(A) binding protein nuclear 1	Homo sapiens	89-93
23281927-4	2013	Modeling showed more arginine-arene interactions for galectin-3 than for galectin-1.	Arginine	21-29	galectin 1	Homo sapiens	73-83
23299939-4	2013	As observed with the THO complex subunit Thoc5, Chtop binds to the NTF2-like domain of Nxf1, and this interaction requires arginine methylation of Chtop.	Arginine	123-131	chromatin target of PRMT1	Homo sapiens	48-53
23299939-4	2013	As observed with the THO complex subunit Thoc5, Chtop binds to the NTF2-like domain of Nxf1, and this interaction requires arginine methylation of Chtop.	Arginine	123-131	chromatin target of PRMT1	Homo sapiens	147-152
23184932-8	2013	The extended region of helix alpha1 constituted an expanded EIAV-CA(N) oligomeric interface and overlapped with the HIV-1-CA hexamer-core residue Arg(18), helical in structure and pivotal in assembly.	Arginine	146-149	adrenoceptor alpha 1D	Homo sapiens	29-35
23125209-10	2013	Also, arginine treatment reduced HIF-1alpha, as well as VEGF expression in normoxic BERK mice, supporting a role of NO bioavailability in HIF-1alpha activation.	Arginine	6-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	33-43
23125209-10	2013	Also, arginine treatment reduced HIF-1alpha, as well as VEGF expression in normoxic BERK mice, supporting a role of NO bioavailability in HIF-1alpha activation.	Arginine	6-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	138-148
28355564-2	2017	Here, we report that SMARCAD1 preferentially associates with H3 arginine 26 citrullination (H3R26Cit) peptides present on arrays composed of 384 histone peptides harboring distinct post-transcriptional modifications.	Arginine	64-72	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	Homo sapiens	21-29
23001044-2	2013	NO synthase can metabolize L-arginine (ARG) to generate NO and L-citrulline (CIT).	Arginine	27-37	citron rho-interacting serine/threonine kinase	Homo sapiens	77-80
23001044-2	2013	NO synthase can metabolize L-arginine (ARG) to generate NO and L-citrulline (CIT).	Arginine	39-42	citron rho-interacting serine/threonine kinase	Homo sapiens	77-80
23001044-8	2013	Furthermore, high CIT-to-ARG ratio was significantly correlated with abnormal ABPM profile, including nocturnal hypertension, increased diastolic BP load, and nocturnal BP non-dipping.	Arginine	25-28	citron rho-interacting serine/threonine kinase	Homo sapiens	18-21
23001044-10	2013	CONCLUSIONS: Plasma CIT-to-ARG ratio may serve as a useful marker of cardiovascular outcome in children with early CKD.	Arginine	27-30	citron rho-interacting serine/threonine kinase	Homo sapiens	20-23
28188302-10	2017	In human VAChT, residue 360 is located in a conserved region and substitution of arginine for glycine is predicted to disrupt proper protein folding and membrane embedding.	Arginine	81-89	solute carrier family 18 member A3	Homo sapiens	9-14
23210739-2	2013	The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by using polymerase chain reaction-restriction fragment length polymorphism method followed by direct sequencing.	Arginine	76-84	transformation related protein 53, pseudogene	Mus musculus	63-66
23210739-2	2013	The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by using polymerase chain reaction-restriction fragment length polymorphism method followed by direct sequencing.	Arginine	76-84	transformed mouse 3T3 cell double minute 2	Mus musculus	147-151
28191887-5	2017	Suppression of arginine-creatine metabolism by CKMT1-directed shRNAs or by the small molecule cyclocreatine selectively decreased the viability, promoted the cell cycle arrest and apoptosis of human EVI1-positive cell lines, and prolonged survival in both orthotopic xenograft models and mouse models of primary AML.	Arginine	15-23	creatine kinase, mitochondrial 1A	Homo sapiens	47-52
28191887-5	2017	Suppression of arginine-creatine metabolism by CKMT1-directed shRNAs or by the small molecule cyclocreatine selectively decreased the viability, promoted the cell cycle arrest and apoptosis of human EVI1-positive cell lines, and prolonged survival in both orthotopic xenograft models and mouse models of primary AML.	Arginine	15-23	RUNX family transcription factor 1	Homo sapiens	199-203
23296605-7	2013	Citrullination of specific arginine residues in native S100A3 can be mimicked by site-directed mutagenic substitution of Arg/Ala.	Arginine	27-35	S100 calcium binding protein A3	Homo sapiens	55-61
23296605-7	2013	Citrullination of specific arginine residues in native S100A3 can be mimicked by site-directed mutagenic substitution of Arg/Ala.	Arginine	121-124	S100 calcium binding protein A3	Homo sapiens	55-61
28191887-6	2017	CKMT1 inhibition altered mitochondrial respiration and ATP production, an effect that was abrogated by phosphocreatine-mediated reactivation of the arginine-creatine pathway.	Arginine	148-156	creatine kinase, mitochondrial 1A	Homo sapiens	0-5
28154142-6	2017	Consistently, the equivalent residue to K305 in human NHA2 has been replaced with arginine, which is a mutation that makes NapA electroneutral.	Arginine	82-90	solute carrier family 9 member B2	Homo sapiens	54-58
23548972-6	2013	This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC.	Arginine	39-47	transmembrane serine protease 11A	Homo sapiens	89-94
28067368-3	2017	We showed that the mRNA and protein expressions of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha were upregulated by arginine supplementation.	Arginine	177-185	peroxisome proliferator activated receptor gamma	Sus scrofa	55-103
28067368-3	2017	We showed that the mRNA and protein expressions of the peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha were upregulated by arginine supplementation.	Arginine	177-185	peroxisome proliferator activated receptor gamma	Sus scrofa	105-114
23615774-4	2013	Arginine, a major component of filaggrin-derived natural moisturizing factors, was concentrated in the middle layer, suggesting that this layer functions in skin hydration.	Arginine	0-8	filaggrin	Homo sapiens	31-40
27270440-0	2017	A TGFbeta-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.	Arginine	84-92	WD repeat domain 77	Homo sapiens	16-21
23267435-2	2012	Almost all described mutations are heterozygous missense mutations affecting a conserved arginine residue in the substrate binding site of IDH1 (R132) or IDH2 (R172).	Arginine	89-97	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	139-143
27270440-1	2017	Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins.	Arginine	8-16	WD repeat domain 77	Homo sapiens	60-65
27270440-1	2017	Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins.	Arginine	8-16	WD repeat domain 77	Homo sapiens	66-71
27958698-6	2017	Since PAD4 catalyzes the citrullination of arginine residue within P1, trypsin-catalyzed digestion of P1 can be prohibited by the addition of PAD4.	Arginine	43-51	peptidyl arginine deiminase 4	Homo sapiens	6-10
23461200-4	2012	The incubation of cells with L-arginine creates conditions for switching on the signal pathway with participation of eNOS --&gt; NO --&gt; sGC --&gt; cGMP --&gt; PKG --&gt; CD38 --&gt; RyR --&gt; Ca2+ and for switching of the PLC - IP3R-dependent pathway.	Arginine	29-39	serglycin	Mus musculus	139-142
23461200-4	2012	The incubation of cells with L-arginine creates conditions for switching on the signal pathway with participation of eNOS --&gt; NO --&gt; sGC --&gt; cGMP --&gt; PKG --&gt; CD38 --&gt; RyR --&gt; Ca2+ and for switching of the PLC - IP3R-dependent pathway.	Arginine	29-39	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	232-236
27958698-6	2017	Since PAD4 catalyzes the citrullination of arginine residue within P1, trypsin-catalyzed digestion of P1 can be prohibited by the addition of PAD4.	Arginine	43-51	peptidyl arginine deiminase 4	Homo sapiens	142-146
28074910-5	2017	Silencing of MYPT1 increased the level of the PRMT5-specific symmetric dimethylation on arginine residues of histone 2 A/4, a repressing gene expression mark, and it resulted in a global change in the expression of genes affecting cellular processes like growth, proliferation and cell death, also affecting the expression of the retinoblastoma protein and c-Myc.	Arginine	88-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	357-362
22968170-0	2012	Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.	Arginine	0-8	transportin 1	Homo sapiens	50-61
22874569-2	2012	Here we have found that L-Arg depletion inhibited expression of different membrane antigens, including CD247 (CD3zeta), and led to an ER stress response, as well as cell cycle arrest at G(0)/G(1) in both human Jurkat and peripheral blood mitogen-activated T cells, without undergoing apoptosis.	Arginine	24-29	CD247 molecule	Homo sapiens	103-108
22874569-2	2012	Here we have found that L-Arg depletion inhibited expression of different membrane antigens, including CD247 (CD3zeta), and led to an ER stress response, as well as cell cycle arrest at G(0)/G(1) in both human Jurkat and peripheral blood mitogen-activated T cells, without undergoing apoptosis.	Arginine	24-29	CD247 molecule	Homo sapiens	110-117
27503676-0	2017	Arginine (Di)methylated Human Leukocyte Antigen Class I Peptides Are Favorably Presented by HLA-B*07.	Arginine	0-8	major histocompatibility complex, class I, B	Homo sapiens	92-97
23143655-2	2012	In differentiated human endothelial cells, it is well known that L-arginine uptake via cationic amino acid transporters (y(+)/CAT) or system y(+)L is required for the NO synthesis via endothelial nitric oxide synthase, but there are no reports in human endothelial progenitor cell (hEPC).	Arginine	65-75	hepcidin antimicrobial peptide	Homo sapiens	282-286
23143655-5	2012	The results showed that L-arginine uptake is higher in hEPC-14d than in hEPC-3d.	Arginine	24-34	hepcidin antimicrobial peptide	Homo sapiens	55-59
23143655-5	2012	The results showed that L-arginine uptake is higher in hEPC-14d than in hEPC-3d.	Arginine	24-34	hepcidin antimicrobial peptide	Homo sapiens	72-76
23143655-6	2012	Kinetic parameters for L-arginine transport showed the existence of at least 2 transporter systems in hEPC: a high affinity transporter system (K(m)= 4.8 +- 1.1 muM for hEPC-3d and 6.1 +- 2.4 muM for hEPC-14d) and a medium affinity transporter system (K(m) = 85.1 +- 4.0 muM for hEPC-3d and 95.1 +- 8 muM for hEPC-14d).	Arginine	23-33	hepcidin antimicrobial peptide	Homo sapiens	102-106
23143655-6	2012	Kinetic parameters for L-arginine transport showed the existence of at least 2 transporter systems in hEPC: a high affinity transporter system (K(m)= 4.8 +- 1.1 muM for hEPC-3d and 6.1 +- 2.4 muM for hEPC-14d) and a medium affinity transporter system (K(m) = 85.1 +- 4.0 muM for hEPC-3d and 95.1 +- 8 muM for hEPC-14d).	Arginine	23-33	hepcidin antimicrobial peptide	Homo sapiens	169-173
27503676-5	2017	A striking preference was observed in the presentation of arginine (di)methylated peptides for HLA-B*07 molecules, likely because the binding motifs of this allele resemble consensus sequences recognized by arginine methyl-transferases.	Arginine	58-66	major histocompatibility complex, class I, B	Homo sapiens	95-100
27865873-7	2017	Importantly, we demonstrate that the transforming potential of GPR87 was correlated to the receptor signaling, as the signaling-impaired mutant R139A (Arg in the conserved "DRY"-motif at the bottom of transmembrane helix 3 of GPR87 substituted to Ala) showed a lower in vitro cell transformation potential.	Arginine	151-154	G protein-coupled receptor 87	Homo sapiens	63-68
23143655-6	2012	Kinetic parameters for L-arginine transport showed the existence of at least 2 transporter systems in hEPC: a high affinity transporter system (K(m)= 4.8 +- 1.1 muM for hEPC-3d and 6.1 +- 2.4 muM for hEPC-14d) and a medium affinity transporter system (K(m) = 85.1 +- 4.0 muM for hEPC-3d and 95.1 +- 8 muM for hEPC-14d).	Arginine	23-33	hepcidin antimicrobial peptide	Homo sapiens	169-173
23143655-6	2012	Kinetic parameters for L-arginine transport showed the existence of at least 2 transporter systems in hEPC: a high affinity transporter system (K(m)= 4.8 +- 1.1 muM for hEPC-3d and 6.1 +- 2.4 muM for hEPC-14d) and a medium affinity transporter system (K(m) = 85.1 +- 4.0 muM for hEPC-3d and 95.1 +- 8 muM for hEPC-14d).	Arginine	23-33	hepcidin antimicrobial peptide	Homo sapiens	169-173
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	solute carrier family 1 member 7	Homo sapiens	85-117
23143655-6	2012	Kinetic parameters for L-arginine transport showed the existence of at least 2 transporter systems in hEPC: a high affinity transporter system (K(m)= 4.8 +- 1.1 muM for hEPC-3d and 6.1 +- 2.4 muM for hEPC-14d) and a medium affinity transporter system (K(m) = 85.1 +- 4.0 muM for hEPC-3d and 95.1 +- 8 muM for hEPC-14d).	Arginine	23-33	hepcidin antimicrobial peptide	Homo sapiens	169-173
23143655-10	2012	In conclusion, this study allowed to identity a functional L-arginine/NO pathway in two hEPC differentiation stages, which improves the understanding of the physiology of these precursor cells.	Arginine	59-69	hepcidin antimicrobial peptide	Homo sapiens	88-92
28115489-1	2017	BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease.	Arginine	257-265	zinc finger C3HC-type containing 1	Homo sapiens	220-226
22859723-8	2012	Activation of free fatty acid 1 receptor (FFAR1) by each of these agonists is differentially affected by mutations of two arginine residues, previously found to be important for FFAR1 binding and activation.	Arginine	122-130	free fatty acid receptor 1	Homo sapiens	42-47
22859723-8	2012	Activation of free fatty acid 1 receptor (FFAR1) by each of these agonists is differentially affected by mutations of two arginine residues, previously found to be important for FFAR1 binding and activation.	Arginine	122-130	free fatty acid receptor 1	Homo sapiens	178-183
28115489-1	2017	BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease.	Arginine	267-270	zinc finger C3HC-type containing 1	Homo sapiens	220-226
27802239-7	2017	Genetic testing revealed a heterozygous guanine to cytosine mutation at the first base of codon 389 (c.1165G>A) of MAPT, the tau gene, resulting in a glycine to arginine substitution in the patient and two unaffected relatives.	Arginine	161-169	microtubule associated protein tau	Homo sapiens	115-119
23035243-4	2012	An analogous interaction of P218 with human DHFR is disfavored because of three species-dependent amino acid substitutions in the vicinity of the conserved Arg.	Arginine	156-159	dihydrofolate reductase	Homo sapiens	44-48
22383090-8	2012	Arginine supplementation decreased muscle pH at 45 min postmortem (P = 0.001), indicating elevated early postmortem glycolysis, and CLA and arginine independently increased PGC-1alpha gene expression in longissimus muscle.	Arginine	140-148	PPARG coactivator 1 alpha	Sus scrofa	173-183
27802239-7	2017	Genetic testing revealed a heterozygous guanine to cytosine mutation at the first base of codon 389 (c.1165G>A) of MAPT, the tau gene, resulting in a glycine to arginine substitution in the patient and two unaffected relatives.	Arginine	161-169	microtubule associated protein tau	Homo sapiens	125-128
26727234-3	2017	Previous study suggested that the substitution of alanine with proline at position 30 of Rab5a reduces the GTPase activity around 12-fold, while, with arginine substitution stimulates the intrinsic GTP hydrolysis by 5-fold.	Arginine	151-159	RAB5A, member RAS oncogene family	Homo sapiens	89-94
22532369-3	2012	Previously, it was demonstrated that protein arginine methyltransferase 1 (PRMT1)-dependent arginine modification of FoxO1 interferes with Akt-dependent phosphorylation, both in cancer cells and in the Caenorhabditis elegans model, suggesting that this additional modification of FoxO1 might be critical in its transcriptional activity.	Arginine	45-53	forkhead box O1	Mus musculus	117-122
29318161-9	2017	Additionally, PAD2/4 activity modified the arginine residues of a reporter protein (fibrinogen) in vitro.	Arginine	43-51	MMTV LTR integration site 2	Mus musculus	14-18
22698687-7	2012	Ethanol amnesia was also prevented by pre-test administration of L-arginine (1.2 mug/mouse, intra-CA1), a NO precursor.	Arginine	65-75	carbonic anhydrase 1	Mus musculus	98-101
22698687-10	2012	Moreover, intra-CA1 microinjection of L-NAME reversed the L-arginine-induced potentiation of the nicotine response.	Arginine	58-68	carbonic anhydrase 1	Mus musculus	16-19
22687724-7	2012	Our results also indicated that intra-CA1 administration of L-arginine and L-NAME, in the presence or absence of ranitidine, exerted an anxiogenic effect.	Arginine	60-70	carbonic anhydrase 1	Mus musculus	38-41
22761421-2	2012	In this report, we show that PRMT7 interacts with the BRG1-based hSWI/SNF chromatin remodeling complex and specifically methylates histone H2A Arg-3 (H2AR3) and histone H4 Arg-3 (H4R3).	Arginine	143-146	protein arginine N-methyltransferase 7	Mus musculus	29-34
22761421-2	2012	In this report, we show that PRMT7 interacts with the BRG1-based hSWI/SNF chromatin remodeling complex and specifically methylates histone H2A Arg-3 (H2AR3) and histone H4 Arg-3 (H4R3).	Arginine	172-175	protein arginine N-methyltransferase 7	Mus musculus	29-34
22068917-11	2012	A combination of arginine and glutamine significantly decreased TNF-alpha and IL-1beta mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum.	Arginine	17-25	interleukin 10	Rattus norvegicus	191-196
22809434-1	2012	BACKGROUND: Mutations at arginine 132 of isocitrate dehydrogenase 1/2 (IDH1/2) have recently been demonstrated to be recurrent gene alterations in acute myeloid leukemia (AML).	Arginine	25-33	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-77
22775217-5	2012	Activation of AQP4, p66Shc, ATF-6, NADPH oxidase subunits p22phox, gp91phox and matrix metalloproteinase 2 (P &lt; 0.01) was significant and was suppressed by arginine, rhein and indometacin but not by l-arginine.	Arginine	159-167	aquaporin 4	Rattus norvegicus	14-18
22775217-5	2012	Activation of AQP4, p66Shc, ATF-6, NADPH oxidase subunits p22phox, gp91phox and matrix metalloproteinase 2 (P &lt; 0.01) was significant and was suppressed by arginine, rhein and indometacin but not by l-arginine.	Arginine	202-212	aquaporin 4	Rattus norvegicus	14-18
22653663-0	2012	The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis.	Arginine	14-22	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	30-35
22696221-2	2012	l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase, providing the substrate arginine for eNOS and NO production in endothelial cells.	Arginine	28-38	argininosuccinate lyase	Bos taurus	91-114
22696221-2	2012	l-Citrulline is recycled to l-arginine by two enzymes, argininosuccinate synthase (AS) and argininosuccinate lyase, providing the substrate arginine for eNOS and NO production in endothelial cells.	Arginine	30-38	argininosuccinate lyase	Bos taurus	91-114
22619177-6	2012	Puromycin-sensitive aminopeptidase is responsible for the peptidase activity that cleaves the Arg-452-Arg-453 bond to generate the intermediate pVP2-452 polypeptide.	Arginine	94-97	aminopeptidase puromycin sensitive	Homo sapiens	0-34
22619177-6	2012	Puromycin-sensitive aminopeptidase is responsible for the peptidase activity that cleaves the Arg-452-Arg-453 bond to generate the intermediate pVP2-452 polypeptide.	Arginine	102-105	aminopeptidase puromycin sensitive	Homo sapiens	0-34
22764101-2	2012	Here, we investigated the role of ASS1 as a biomarker of response to the arginine-lowering agent, pegylated arginine deiminase (ADI-PEG20), in lymphoid malignancies.	Arginine	73-81	argininosuccinate synthase 1	Homo sapiens	34-38
22764101-9	2012	In summary, ASS1 promoter methylation contributes to arginine auxotrophy and represents a novel biomarker for evaluating the efficacy of arginine deprivation in patients with lymphoma.	Arginine	53-61	argininosuccinate synthase 1	Homo sapiens	12-16
22764101-9	2012	In summary, ASS1 promoter methylation contributes to arginine auxotrophy and represents a novel biomarker for evaluating the efficacy of arginine deprivation in patients with lymphoma.	Arginine	137-145	argininosuccinate synthase 1	Homo sapiens	12-16
22832247-4	2012	Codon reengineering studies suggest that Trm9-catalyzed tRNA modifications promote fidelity during the translation of specific genes, those rich in arginine and glutamic acid codons from mixed boxes.	Arginine	148-156	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase	Saccharomyces cerevisiae S288C	41-45
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Arginine	98-101	defensin, alpha, 20	Mus musculus	9-19
22566697-2	2012	In mouse cryptdin-4 (Crp4) and rhesus myeloid alpha-defensin-4 (RMAD4), complete substitutions of Arg with Lys affect bactericidal peptide activity very differently.	Arginine	98-101	defensin, alpha, 20	Mus musculus	21-25
22566697-3	2012	Lys-for-Arg mutagenesis attenuates Crp4, but RMAD4 activity remains mostly unchanged.	Arginine	8-11	defensin, alpha, 20	Mus musculus	35-39
22566697-5	2012	In Crp4, small-angle x-ray scattering analyses showed that Arg-to-Lys replacements shifted the induced nanoporous phases to a different range of lipid compositions compared with the Arg-rich native peptide, consistent with the attenuation of bactericidal activity by Lys-for-Arg mutations.	Arginine	59-62	defensin, alpha, 20	Mus musculus	3-7
22572614-7	2012	The administration of L-Arg promoted the synthesis of NO and significantly elevated the expressions of VEGF, eNOS and PTC density with the conspicuous loss of HIF-1alpha and TGF-beta1 expressions and ultimately ameliorated renal fibrosis, which was markedly aggravated by L-NAME administration.	Arginine	22-27	vascular endothelial growth factor A	Rattus norvegicus	103-107
22682249-3	2012	Here, we have generated mice bearing lysine to arginine mutations at one (p53(K117R)) or three (p53(3KR); K117R+K161R+K162R) of p53 acetylation sites.	Arginine	47-55	transformation related protein 53, pseudogene	Mus musculus	74-77
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Arginine	52-55	microRNA 222	Homo sapiens	110-117
22404651-0	2012	A triple arg motif mediates alpha(2B)-adrenergic receptor interaction with Sec24C/D and export.	Arginine	9-12	adrenoceptor alpha 2B	Homo sapiens	28-57
22633414-3	2012	The covalent inactivators ethacrynic acid and thiobenzofurazan cause the specific degradation of glutathione-S-transferase when linked to Boc(3)Arg.	Arginine	144-147	glutathione S-transferase kappa 1	Homo sapiens	97-122
22467876-0	2012	Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).	Arginine	35-43	cytoplasmic linker associated protein 2	Homo sapiens	99-138
22467876-0	2012	Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).	Arginine	35-43	cytoplasmic linker associated protein 2	Homo sapiens	140-146
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Arginine	138-146	cytoplasmic linker associated protein 2	Homo sapiens	82-88
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Arginine	138-146	cytoplasmic linker associated protein 2	Homo sapiens	159-165
22345554-4	2012	Mutation of the methylation site at K206 of FXR to an arginine prevented methylation by Set7/9.	Arginine	54-62	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	88-94
28271477-2	2017	PRMT5 in complex with MEP50/p44/WDR77 associates with a plethora of partner proteins to symmetrically dimethylate arginine residues on target proteins in both the nucleus and the cytoplasm.	Arginine	114-122	WD repeat domain 77	Homo sapiens	22-27
22095282-0	2012	Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.	Arginine	0-8	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	45-49
22095282-3	2012	We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling.	Arginine	81-89	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	34-70
22095282-3	2012	We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling.	Arginine	81-89	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	72-76
22095282-3	2012	We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling.	Arginine	81-89	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	142-146
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Arginine	156-165	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	15-19
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Arginine	156-165	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	79-83
28271477-2	2017	PRMT5 in complex with MEP50/p44/WDR77 associates with a plethora of partner proteins to symmetrically dimethylate arginine residues on target proteins in both the nucleus and the cytoplasm.	Arginine	114-122	WD repeat domain 77	Homo sapiens	28-31
28271477-2	2017	PRMT5 in complex with MEP50/p44/WDR77 associates with a plethora of partner proteins to symmetrically dimethylate arginine residues on target proteins in both the nucleus and the cytoplasm.	Arginine	114-122	WD repeat domain 77	Homo sapiens	32-37
27956631-1	2016	Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies.	Arginine	78-86	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-41
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Arginine	156-165	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	79-83
22095282-8	2012	Together, our results indicate that arginine methylation of ASK1 by PRMT1 contributes to the regulation of stress-induced signaling that controls a variety of cellular events including apoptosis.	Arginine	36-44	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	60-64
27956631-2	2016	In the hematopoietic system, mutations in IDH1 at arginine (R) 132 and in IDH2 at R140 and R172 are commonly observed in acute myeloid leukemia, and elevated 2HG is observed in cells and serum.	Arginine	50-58	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	42-46
28066349-2	2016	The CPA2 gene in yeast encodes a large subunit of arginine-specific carbamoyl phosphate synthetase (CPS) and is involved in arginine biosynthesis.	Arginine	50-58	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2	Saccharomyces cerevisiae S288C	4-8
22441676-3	2012	In the present study, we developed a transgenic mouse (designated H60H Tg) expressing a variant of H60, designated H60H, in which the arginine residue at position 4 of the H60 epitope sequence (LTFNYRNL) is replaced by a histidine residue (LTFHYRNL).	Arginine	134-142	histocompatibility 60a	Mus musculus	66-69
22441676-3	2012	In the present study, we developed a transgenic mouse (designated H60H Tg) expressing a variant of H60, designated H60H, in which the arginine residue at position 4 of the H60 epitope sequence (LTFNYRNL) is replaced by a histidine residue (LTFHYRNL).	Arginine	134-142	histocompatibility 60a	Mus musculus	99-102
22334657-5	2012	Consistent with an autoinhibitory role of the VD, we identified Arg-376 in the Drp1 stalk domain as necessary for Mff interaction, assembly into spirals, and mitochondrial fission.	Arginine	64-67	dynamin 1 like	Homo sapiens	79-83
27911799-5	2016	A key player in this catalyzed reaction is an arginine residue, Arg178 in Galphai1, which is already an intrinsic part of the catalytic center in Galpha in contrast to small GTPases, at which the corresponding GTPase-activating protein (GAP) provides the arginine "finger."	Arginine	46-54	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	74-80
22334657-5	2012	Consistent with an autoinhibitory role of the VD, we identified Arg-376 in the Drp1 stalk domain as necessary for Mff interaction, assembly into spirals, and mitochondrial fission.	Arginine	64-67	mitochondrial fission factor	Homo sapiens	114-117
22334657-10	2012	This in turn modulates Arg-376-dependent OMM targeting of Drp1 via multivalent interactions with Mff.	Arginine	23-26	dynamin 1 like	Homo sapiens	58-62
22334657-10	2012	This in turn modulates Arg-376-dependent OMM targeting of Drp1 via multivalent interactions with Mff.	Arginine	23-26	mitochondrial fission factor	Homo sapiens	97-100
27911799-5	2016	A key player in this catalyzed reaction is an arginine residue, Arg178 in Galphai1, which is already an intrinsic part of the catalytic center in Galpha in contrast to small GTPases, at which the corresponding GTPase-activating protein (GAP) provides the arginine "finger."	Arginine	255-263	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	74-80
27934952-3	2016	In some bacteria bifunctional N-acetylglutamate synthase-kinase (NAGS-K) catalyzes the first two steps of L-arginine biosynthesis.	Arginine	106-116	N-acetylglutamate synthase	Mus musculus	65-69
22308037-0	2012	Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.	Arginine	67-75	peroxiredoxin	Rhodococcus jostii RHA1	55-65
22308037-0	2012	Distal heme pocket residues of B-type dye-decolorizing peroxidase: arginine but not aspartate is essential for peroxidase activity.	Arginine	67-75	peroxiredoxin	Rhodococcus jostii RHA1	111-121
27934952-5	2016	L-arginine increased thermal stability of the NAGS-K from Maricaulis maris (MmNAGS-K) while it destabilized the NAGS-K from Xanthomonas campestris (XcNAGS-K).	Arginine	0-10	N-acetylglutamate synthase	Mus musculus	46-50
27934952-5	2016	L-arginine increased thermal stability of the NAGS-K from Maricaulis maris (MmNAGS-K) while it destabilized the NAGS-K from Xanthomonas campestris (XcNAGS-K).	Arginine	0-10	N-acetylglutamate synthase	Mus musculus	78-82
27934952-7	2016	The partition coefficient of the mNAGS increased in the presence of L-arginine suggesting smaller hydrodynamic radius due to change in either conformation or oligomerization.	Arginine	68-78	N-acetylglutamate synthase	Mus musculus	33-38
22235122-6	2012	We found that the C-terminal 16-amino acid fragment of Rad27, a highly polybasic region due to the presence of multiple positively charged lysine and arginine residues, was sufficient and necessary for the stimulation of both Rad27 and Dna2.	Arginine	150-158	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	55-60
27754867-4	2016	We then found that deletion mutant Delta1-36 (TRPP3 missing fragment Met-1-Arg-36) has a similar function as wild-type TRPP3, whereas Delta1-38 is functionally dead, suggesting the importance of Val-37 or Cys-38.	Arginine	75-78	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	46-51
22235122-6	2012	We found that the C-terminal 16-amino acid fragment of Rad27, a highly polybasic region due to the presence of multiple positively charged lysine and arginine residues, was sufficient and necessary for the stimulation of both Rad27 and Dna2.	Arginine	150-158	multifunctional nuclease RAD27	Saccharomyces cerevisiae S288C	226-231
22422993-3	2012	Drugs patterned on the integrin ligand sequence Arg-Gly-Asp have a basic moiety that binds the alpha(IIb) subunit and a carboxyl group that coordinates the MIDAS Mg(2+) in the beta(3) subunits.	Arginine	48-51	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	176-183
27754867-4	2016	We then found that deletion mutant Delta1-36 (TRPP3 missing fragment Met-1-Arg-36) has a similar function as wild-type TRPP3, whereas Delta1-38 is functionally dead, suggesting the importance of Val-37 or Cys-38.	Arginine	75-78	granzyme M	Homo sapiens	69-74
27754869-6	2016	Moreover, we propose that ligand binding triggers translocation of Arg-143 from the membrane interface into the membrane to enable alignment with oppositely charged aspartate residues within CD3zeta and activation of CD3zeta-signaling.	Arginine	67-70	CD247 molecule	Homo sapiens	191-198
27754869-6	2016	Moreover, we propose that ligand binding triggers translocation of Arg-143 from the membrane interface into the membrane to enable alignment with oppositely charged aspartate residues within CD3zeta and activation of CD3zeta-signaling.	Arginine	67-70	CD247 molecule	Homo sapiens	217-224
27841873-2	2016	Recurrent somatic mutations in DNA methyltransferase 3A (DNMT3A), most frequently at arginine 882 (DNMT3AR882), have been observed in AML and in individuals with clonal hematopoiesis in the absence of leukemic transformation.	Arginine	85-93	DNA methyltransferase 3 alpha	Homo sapiens	31-55
27841873-2	2016	Recurrent somatic mutations in DNA methyltransferase 3A (DNMT3A), most frequently at arginine 882 (DNMT3AR882), have been observed in AML and in individuals with clonal hematopoiesis in the absence of leukemic transformation.	Arginine	85-93	DNA methyltransferase 3 alpha	Homo sapiens	57-63
22803945-8	2012	The most likely candidates to interact with anionic groups of mitochondrial phospholipids are invariant lysine and arginine residues in the environment of the myoglobin heme cavity, which do not change their ionization state in the pH range investigated.	Arginine	115-123	myoglobin	Homo sapiens	159-168
27614253-3	2016	This cycle indicates that argininosuccinate synthase (ASS) catalyzes l-citrulline (l-cit) conversion to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms l-arginine (l-arg), the substrate for NO synthesis.	Arginine	199-209	argininosuccinate synthase 1	Homo sapiens	26-52
22271514-7	2012	Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA-binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90beta in vitro, indicating that STAT3 requires a functional DNA-binding domain for full direct interaction with Hsp90.	Arginine	35-43	heat shock protein 90 alpha family class B member 1	Homo sapiens	228-237
22271514-7	2012	Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA-binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90beta in vitro, indicating that STAT3 requires a functional DNA-binding domain for full direct interaction with Hsp90.	Arginine	35-43	heat shock protein 90 alpha family class A member 1	Homo sapiens	228-233
22291186-4	2012	The replacement of the arginines in this motif with alanines resulted in the extensive accumulation of CD1d in lysosomes but did not affect the cell surface expression.	Arginine	23-32	CD1d molecule	Homo sapiens	103-107
21625899-5	2012	Then, based on the optimized geometric structure of the Arg(+)+9H(2)O system, the electronic structure of Arg(+) in the potential of water was calculated using the SCCE method.	Arginine	106-109	kallikrein related peptidase 7	Homo sapiens	164-168
21625899-6	2012	Finally, by performing SCCE calculations, the effect of water on the electronic structure of Arg(+) was simulated with dipoles.	Arginine	93-96	kallikrein related peptidase 7	Homo sapiens	23-27
21948185-2	2012	The objective of this study was to determine the influence of short-term supplementation with L-arginine in stress conditions, induced by ischemia-reperfusion syndrome, by assessing the damage to muscular and hepatic cells on the basis of creatine kinase (CK), alanine aminotransferase (ALAT) and aspartic aminotransferase (AspAT) activity in blood and the level of oxygen free radicals in analyzed tissues of rats.	Arginine	94-104	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	297-322
21948185-2	2012	The objective of this study was to determine the influence of short-term supplementation with L-arginine in stress conditions, induced by ischemia-reperfusion syndrome, by assessing the damage to muscular and hepatic cells on the basis of creatine kinase (CK), alanine aminotransferase (ALAT) and aspartic aminotransferase (AspAT) activity in blood and the level of oxygen free radicals in analyzed tissues of rats.	Arginine	94-104	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	324-329
21948185-4	2012	Supplementation with L-arginine led to a reduction in serum activity of CK and AspAT and reduction of the level of free radicals in analysed tissues.	Arginine	21-31	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	79-84
22038625-0	2012	Arginine decreases peroxisome proliferator-activated receptor-gamma activity via c-Jun.	Arginine	0-8	peroxisome proliferator activated receptor alpha	Rattus norvegicus	19-61
22038625-1	2012	We have previously shown in the post ischemic gut that enteral arginine enhanced injury and inflammation via c-Jun/AP-1 and abrogated peroxisome proliferator-activated receptor (PPAR) gamma activity.	Arginine	63-71	peroxisome proliferator activated receptor alpha	Rattus norvegicus	134-176
22038625-1	2012	We have previously shown in the post ischemic gut that enteral arginine enhanced injury and inflammation via c-Jun/AP-1 and abrogated peroxisome proliferator-activated receptor (PPAR) gamma activity.	Arginine	63-71	peroxisome proliferator activated receptor alpha	Rattus norvegicus	178-182
22248473-8	2012	Restoring intracellular TRX1 protein in cisplatin-resistant cells resulted in lowering ASS and fumarase mRNAs, which in turn sensitized them to arginine deprivation.	Arginine	144-152	thioredoxin	Homo sapiens	24-28
22120830-7	2012	L-arginine stimulated islet cNOS activity and did not affect islet iNOS activity.	Arginine	0-10	nitric oxide synthase 3, endothelial cell	Mus musculus	28-32
22119597-2	2012	We have observed allelic instability in UV-induced cutaneous tumors at the mt-Tr locus encoding the mitochondrial tRNA for arginine.	Arginine	123-131	tRNA arginine, mitochondrial	Mus musculus	75-80
21882174-5	2012	It was found that of human ferritin light chain, bacterial arginine deiminase, human granulocyte colony stimulating factor were synthesized evidently with the self-assembly function, L-arginine-degrading activity, and the correct secondary structure, respectively, through the fusion expression using N-ePGK.	Arginine	183-193	colony stimulating factor 3	Homo sapiens	85-122
22052239-7	2012	Two out of 86 cases revealed a 130th codon G&gt;A missense mutation in exon 8 of PTEN which resulted in an Arg change to Gln in the PTEN protein structure; and a 334th codon A&gt;T missense mutation in exon 8 of PTEN, which resulted in an Asn change to Lys in the PTEN protein structure.	Arginine	107-110	phosphatase and tensin homolog	Homo sapiens	81-85
22227192-5	2012	Mutation of two lysine (K) residues in its GK motif to either arginine (R) or glutamine (Q) blocked SPK1 ubiquitination and prevented its degradation by the proteasome.	Arginine	62-70	sphingosine kinase 1	Homo sapiens	100-104
22178073-0	2012	Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer.	Arginine	115-123	serine and arginine rich splicing factor 9	Homo sapiens	132-137
22178073-0	2012	Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer.	Arginine	115-123	serine and arginine rich splicing factor 9	Homo sapiens	138-144
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Arginine	296-304	p38a MAP kinase	Drosophila melanogaster	323-330
21741925-6	2012	We sequenced the TSFM gene, encoding the mitochondrial translation factor EFTs and identified a homozygous mutation changing a highly conserved arginine into a tryptophan (R312W).	Arginine	144-152	Ts translation elongation factor, mitochondrial	Homo sapiens	17-21
22056627-3	2012	The substitution of arginine to histidine (R279H), due to a c.836G&gt;A mutation in exon 7 of the p63 gene, represents 55% of the identified mutations and is considered a mutational hot spot.	Arginine	20-28	tumor protein p63	Homo sapiens	98-101
22738901-3	2012	In ewes, Arg and Gluc increase significantly in the uterine lumen between Days 10 and 15 of pregnancy due to increased expression of transporters for Gluc (SLC2A1 and SLC5A1) and Arg (SLC7A2B) by uterine epithelia.	Arginine	9-12	glucose transport protein	Sus scrofa	156-162
22738901-3	2012	In ewes, Arg and Gluc increase significantly in the uterine lumen between Days 10 and 15 of pregnancy due to increased expression of transporters for Gluc (SLC2A1 and SLC5A1) and Arg (SLC7A2B) by uterine epithelia.	Arginine	9-12	solute carrier family 5 member 1	Sus scrofa	167-173
23071787-7	2012	The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered.	Arginine	133-136	H3 histone pseudogene 16	Homo sapiens	26-29
22911765-1	2012	The peptidylarginine deiminase (PAD) family of enzymes post-translationally convert positively charged arginine residues in substrate proteins to the neutral, non-standard residue citrulline.	Arginine	12-20	peptidyl arginine deiminase 4	Homo sapiens	32-35
22911765-8	2012	Further, ChIP analysis of two of the most highly up- and down-regulated genes (PTN and MAGEA12, respectively) found that PAD2 binds directly to these gene promoters and that the likely mechanism by which PAD2 regulates expression of these genes is via citrullination of arginine residues 2-8-17 on histone H3 tails.	Arginine	270-278	MAGE family member A12	Homo sapiens	87-94
22848442-9	2012	In trophoblast JAR cells, treatment with arginine and its metabolites enhanced Stat3, PKB, and S6K1 activation and facilitated cellular adhesion activity.	Arginine	41-49	protein tyrosine kinase 2 beta	Homo sapiens	86-89
22848442-9	2012	In trophoblast JAR cells, treatment with arginine and its metabolites enhanced Stat3, PKB, and S6K1 activation and facilitated cellular adhesion activity.	Arginine	41-49	ribosomal protein S6 kinase B1	Homo sapiens	95-99
22848454-3	2012	Gating of murine P2X7 can be induced by the soluble ligand ATP, as well as by NAD(+)-dependent ADP-ribosylation of arginine 125, a posttranslational protein modification catalyzed by the toxin-related ecto-enzymes ART2.1 and ART2.2.	Arginine	115-123	ADP-ribosyltransferase 2b	Mus musculus	225-231
22897519-2	2012	Indoleamine 2,3-dioxygenase (IDO) and arginase type I (ARG) catabolize tryptophane and arginine, respectively, and exert proapoptotic and antiproliferative effects on T-cells.	Arginine	87-95	indoleamine 2,3-dioxygenase 1	Homo sapiens	0-27
22897519-2	2012	Indoleamine 2,3-dioxygenase (IDO) and arginase type I (ARG) catabolize tryptophane and arginine, respectively, and exert proapoptotic and antiproliferative effects on T-cells.	Arginine	87-95	indoleamine 2,3-dioxygenase 1	Homo sapiens	29-32
22082147-2	2011	While human IDO is able to oxidize both L- and D-Trp, human TDO (hTDO) displays major specificity for L-Trp.	Arginine	40-42	indoleamine 2,3-dioxygenase 1	Homo sapiens	12-15
21787888-7	2011	On the other hand, no arginine or lysine residues are found in the active site of MMP-7.	Arginine	22-30	matrix metallopeptidase 7	Homo sapiens	82-87
27614253-3	2016	This cycle indicates that argininosuccinate synthase (ASS) catalyzes l-citrulline (l-cit) conversion to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms l-arginine (l-arg), the substrate for NO synthesis.	Arginine	199-204	argininosuccinate synthase 1	Homo sapiens	26-52
27613419-5	2016	We demonstrate that Scd6 gets arginine methylated at its RGG-motif and Hmt1 plays an important role in its methylation.	Arginine	30-38	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	71-75
27699916-4	2016	Previously, we designed PIK1, H-(Nalpha Me)Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 , that was 2.5-fold more resistant to peptidases in human plasma in vitro than L-PIK and equal to it as MLCK inhibitor.	Arginine	43-46	myosin light chain kinase	Homo sapiens	187-191
27783672-1	2016	Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens.	Arginine	103-113	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-32
21917981-3	2011	Genetic breeding programs aimed at enrichment of arginine-171 (171R) prion protein (PrP), the so-called ARR allele, in the sheep population have been demonstrated to be effective in reducing the occurrence of classical scrapie in the field.	Arginine	49-57	major prion protein	Ovis aries	84-87
21949238-2	2011	We describe the interaction of syntenin-1 with ubiquitin through a novel binding site spanning the C terminus of ubiquitin, centered on Arg(72), Leu(73), and Arg(74).	Arginine	136-139	syndecan binding protein	Homo sapiens	31-41
21949238-2	2011	We describe the interaction of syntenin-1 with ubiquitin through a novel binding site spanning the C terminus of ubiquitin, centered on Arg(72), Leu(73), and Arg(74).	Arginine	158-161	syndecan binding protein	Homo sapiens	31-41
21078607-0	2011	Exogenous L-arginine and HDL can alter LDL and ox-LDL-mediated platelet activation: using platelet P-selectin receptor numbers.	Arginine	10-20	selectin P	Homo sapiens	99-109
21078607-4	2011	After incubation with only L-arginine (without lipoproteins), platelet nitric oxide (NO) levels and P-selectin receptor numbers significantly increased compared to the controls (P &lt; .05).	Arginine	27-37	selectin P	Homo sapiens	100-110
21078607-6	2011	However, P-selectin receptor numbers in platelets treated with L-arginine + LDL or L-arginine + ox-LDL decreased compared to the levels in platelets treated with only LDL or ox-LDL (P &lt; .01, P &lt; .001, respectively).	Arginine	63-73	selectin P	Homo sapiens	9-19
21078607-6	2011	However, P-selectin receptor numbers in platelets treated with L-arginine + LDL or L-arginine + ox-LDL decreased compared to the levels in platelets treated with only LDL or ox-LDL (P &lt; .01, P &lt; .001, respectively).	Arginine	83-93	selectin P	Homo sapiens	9-19
21078607-7	2011	Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P &lt; .001).We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.	Arginine	19-29	selectin P	Homo sapiens	71-81
21078607-7	2011	Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P &lt; .001).We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.	Arginine	161-171	selectin P	Homo sapiens	71-81
21078607-7	2011	Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P &lt; .001).We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.	Arginine	161-171	selectin P	Homo sapiens	259-269
21078607-7	2011	Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P &lt; .001).We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.	Arginine	161-171	selectin P	Homo sapiens	71-81
21078607-7	2011	Addition of HDL to L-arginine + ox-LDL caused significant reduction in P-selectin receptor numbers as in the control values (P &lt; .001).We have concluded that L-arginine causes enhanced platelet NO levels and blocks the effects of LDL or ox-LDL on platelet P-selectin receptor numbers and HDL also strengthens this effect of L-arginine.	Arginine	161-171	selectin P	Homo sapiens	259-269
21660538-8	2011	In addition, L-arginine effects on the expression of Rho kinase (ROK), protein kinase C potentiated inhibitor (CPI-17), caldesmon (CaD), and calponin (CaP) were studied by immunoblotting.	Arginine	13-23	caldesmon	Oryctolagus cuniculus	120-129
21660538-11	2011	Ovariectomy increases the expressions of both isoforms of CaD, CaP, and CPI-17; L-arginine treatment induces ROK underexpression, while CaP is overexpressed in the early few days of ovariectomy but returns to the control level at 2 weeks after ovariectomy.	Arginine	80-90	caldesmon	Oryctolagus cuniculus	58-61
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Arginine	113-116	fibronectin 1	Mus musculus	80-91
21875805-0	2011	Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.	Arginine	53-63	histone deacetylase 8	Homo sapiens	129-150
21899894-9	2011	Arginine residues at positions 100 and 100g in IS4V(H) CDR3 play a particularly important role in binding to DI, but this is unlikely to be due to electrostatic interactions with negatively charged amino acids on DI.	Arginine	0-8	cerebellar degeneration-related 3	Mus musculus	55-59
21849672-6	2011	TCR sequence analysis revealed in vivo clonal expansion, convergent recombination, semipublic response, and the notable conservation of a non-germline-encoded Arg residue in the CDR3beta loop.	Arginine	159-162	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-3
21849672-7	2011	Functional testing of a prototype DQ2-alpha-II-reactive TCR by analysis of TCR transfectants and soluble single-chain TCRs indicate that the deamidated residue in the DQ2-alpha-II peptide poses constraints on the TCR structure in which the conserved Arg residue is a critical element.	Arginine	250-253	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	56-59
21730068-4	2011	Detailed analysis, including a comparison of the tertiary structure of Pos5 with the structures of human and bacterial NAD kinases, revealed that Arg-293 of Pos5, corresponding to His-351 of human NAD kinase, confers a positive charge on the surface of NADH-binding site, whereas the corresponding His residue does not.	Arginine	146-149	NAD kinase	Homo sapiens	119-129
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Arginine	89-92	NAD kinase	Homo sapiens	65-75
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Arginine	89-92	NAD kinase	Homo sapiens	163-173
21730068-6	2011	Conversely, simultaneous changes of Ala-330 and His-351 of human NAD kinase into Ser and Arg residues significantly increased the ratio of NADH kinase activity to NAD kinase activity from 0.043 to 1.39; human Ala-330 corresponds to Pos5 Ser-272, which interacts with the side chain of Arg-293.	Arginine	285-288	NAD kinase	Homo sapiens	65-75
21718007-2	2011	The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the l-arginine-bound ferric iNOS heme (Sempombe, J.; et al.	Arginine	92-102	formin 1	Homo sapiens	20-23
21811984-5	2011	RESULTS: A heterozygous 467G&gt;A mutation was found in the patient, resulting in the substitution of arginine (R) by histidine (H) in codon 156 (R156H) in the 1A domain of the KRT10 protein but not in the healthy individuals from the family and the 50 unrelated individuals.	Arginine	102-110	keratin 10	Homo sapiens	177-182
22210999-5	2011	A point mutation from G to C in exon 2 of ITGA2B causing a substitution of the expected amino acid arginine 72 (Arg(72)) by a proline (Pro(72)) was encountered.	Arginine	112-115	integrin subunit alpha 2b	Equus caballus	42-48
21652632-0	2011	Arginine methylation of G3BP1 in response to Wnt3a regulates beta-catenin mRNA.	Arginine	0-8	catenin beta 1	Homo sapiens	61-73
21652632-8	2011	Thus, the protein arginine methylation that targets G3BP1 acts as a novel regulator of Ctnnb1 mRNA.	Arginine	18-26	catenin beta 1	Homo sapiens	87-93
21438496-3	2011	A JIP sequence connected through a flexible linker to either the N-terminus of an inverted TAT sequence (JIP(10)-Delta-TAT(i)) or to a poly arginine sequence (JIP(10)-Delta-R(9)) enabled the potent inhibition of JNK2 (IC(50)   90 nM) and exhibited 10-fold selectivity for JNK2 over JNK1 and JNK3.	Arginine	140-148	sperm associated antigen 9	Homo sapiens	2-5
21438496-10	2011	A control form of JIP(10)-Delta-TAT(i) containing a single leucine to arginine mutation lacks ability to inhibit JNK2 in vitro cell-free and cell-based assays and does not inhibit the migration of PyVMTjnk2+/+ cells.	Arginine	70-78	sperm associated antigen 9	Homo sapiens	18-21
21543646-4	2011	The cytoplasmic domain of CD3 zeta also contains several clusters of arginine and lysine residues.	Arginine	69-77	CD247 molecule	Homo sapiens	26-34
21293034-10	2011	Importantly, Arg, Leu, Gln, and glucose increased the abundance of phosphorylated MTOR, RPS6K, RPS6, and EIF4EBP1 proteins as well as NOS and ODC1 proteins, but only Arg increased the abundance of IFNT protein.	Arginine	13-16	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	105-113
21424129-2	2011	Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes.	Arginine	25-33	ornithine transcarbamylase	Homo sapiens	69-95
21424129-2	2011	Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes.	Arginine	25-33	ornithine transcarbamylase	Homo sapiens	97-100
21424129-2	2011	Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes.	Arginine	25-33	argininosuccinate synthase 1	Homo sapiens	106-134
21424129-2	2011	Endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (OTC) and argininosuccinate synthetase (ASS) enzymes.	Arginine	25-33	argininosuccinate synthase 1	Homo sapiens	136-139
21655091-1	2011	Peptidylarginine deiminase IV (PADI4) catalyzes the conversion of positively charged arginine and methylarginine residues to neutrally charged citrulline, and this activity has been linked to the repression of a limited number of target genes.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	31-36
21531333-0	2011	Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.	Arginine	11-19	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	113-119
21383616-8	2011	RESULTS: Remifentanil and L-arginine pretreatment reduced concentrations of serum aminotransferases and cytokines, decreased the concentrations of hepatic malondialdehyde and myeloperoxidase activity, and increased superoxide dismutase, nitric oxide, and inducible NOS expression in vivo.	Arginine	26-36	myeloperoxidase	Rattus norvegicus	175-190
21402116-5	2011	In RAMP3, these were Trp, Phe, Tyr, Ala, Ser, Thr, Arg and Asn; in RAMP1, Glu, Phe, Tyr, Ala and Asn substitutions were made.	Arginine	51-54	receptor activity modifying protein 3	Homo sapiens	3-8
21333652-2	2011	Using fusion proteins in vitro, in combination with site-directed mutagenesis and surface plasmon resonance measurements, we previously showed that the binding site on sAnk1 for obscurin consists, in part, of six lysine and arginine residues.	Arginine	224-232	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	Homo sapiens	178-186
21471456-2	2011	The importance of Arg in CDR3 for DNA binding has been shown in mice with transgenes coding for anti-DNA V(H) regions; there is also a close correlation between arginines in CDR3 of antibodies and DNA binding.	Arginine	18-21	cerebellar degeneration-related 3	Mus musculus	25-29
21357695-4	2011	The interaction domains were mapped to the acidic CT of tubulin and the basic Arg residues in the alpha(2B)-AR CT, particularly Arg-437, Arg-441, and Arg-446.	Arginine	78-81	adrenoceptor alpha 2B	Homo sapiens	98-110
21357695-4	2011	The interaction domains were mapped to the acidic CT of tubulin and the basic Arg residues in the alpha(2B)-AR CT, particularly Arg-437, Arg-441, and Arg-446.	Arginine	128-131	adrenoceptor alpha 2B	Homo sapiens	98-110
21357695-4	2011	The interaction domains were mapped to the acidic CT of tubulin and the basic Arg residues in the alpha(2B)-AR CT, particularly Arg-437, Arg-441, and Arg-446.	Arginine	128-131	adrenoceptor alpha 2B	Homo sapiens	98-110
21357695-4	2011	The interaction domains were mapped to the acidic CT of tubulin and the basic Arg residues in the alpha(2B)-AR CT, particularly Arg-437, Arg-441, and Arg-446.	Arginine	128-131	adrenoceptor alpha 2B	Homo sapiens	98-110
21357695-5	2011	More importantly, mutation of these Arg residues to disrupt tubulin interaction markedly inhibited alpha(2B)-AR transport to the cell surface and strongly arrested the receptor in the ER.	Arginine	36-39	adrenoceptor alpha 2B	Homo sapiens	99-111
21357695-6	2011	These data provide the first evidence indicating that the alpha(2B)-AR C-terminal Arg cluster mediates its association with tubulin to coordinate its ER-to-cell surface traffic and suggest a novel mechanism of GPCR export through physical contact with microtubules.	Arginine	82-85	adrenoceptor alpha 2B	Homo sapiens	58-70
21357695-6	2011	These data provide the first evidence indicating that the alpha(2B)-AR C-terminal Arg cluster mediates its association with tubulin to coordinate its ER-to-cell surface traffic and suggest a novel mechanism of GPCR export through physical contact with microtubules.	Arginine	82-85	adrenoceptor alpha 2B	Homo sapiens	210-214
21239536-2	2011	We hypothesized that preventing L-arginine (L-arg) uptake in endothelial cells would prevent lipopolysaccharide/tumor necrosis factor-alpha (LPS/TNF)-induced, NO-mediated suppression of cellular proliferation.	Arginine	32-42	tumor necrosis factor	Bos taurus	145-148
21239536-2	2011	We hypothesized that preventing L-arginine (L-arg) uptake in endothelial cells would prevent lipopolysaccharide/tumor necrosis factor-alpha (LPS/TNF)-induced, NO-mediated suppression of cellular proliferation.	Arginine	32-37	tumor necrosis factor	Bos taurus	145-148
27783672-1	2016	Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens.	Arginine	103-113	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	34-40
27783672-1	2016	Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens.	Arginine	115-120	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-32
27783672-1	2016	Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens.	Arginine	115-120	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	34-40
21428916-5	2011	PP2A similarly associates with the upstream regulator of MEK in this signalling pathway, TPL-2 (tumour progression locus-2), in response to arginine availability.	Arginine	140-148	protein phosphatase 2 phosphatase activator	Homo sapiens	0-4
27780200-2	2016	NHBA binds heparin through a conserved Arg-rich region that is the target of two proteases, the meningococcal NalP and human lactoferrin (hLf).	Arginine	39-42	HLF transcription factor, PAR bZIP family member	Homo sapiens	138-141
21428916-5	2011	PP2A similarly associates with the upstream regulator of MEK in this signalling pathway, TPL-2 (tumour progression locus-2), in response to arginine availability.	Arginine	140-148	mitogen-activated protein kinase kinase kinase 8	Homo sapiens	89-94
21308737-2	2011	We have reported that L-arginine, released from extracellular substrates by prolactin (PRL)- and 17beta-estradiol (E2)-induced carboxypeptidase-D in the cell membrane, promotes nitric oxide (NO) production for MCF-7 cell survival.	Arginine	22-32	carboxypeptidase D	Homo sapiens	127-145
27735949-6	2016	We found that almost 90% were arginine auxotrophs, as the expression of argininosuccinate synthetase 1 was lost or significantly reduced.	Arginine	30-38	argininosuccinate synthase 1	Homo sapiens	72-102
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	33-41	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	91-94
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	148-156	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	91-94
27074718-9	2016	Agm upregulates expression of mRNAs SLC7A1, agmatinase and OAZ2 while the combination of Arg and Agm decreased expression of mRNAs for ODC1, SLC7A1, OAZ1 and OAZ3 by oTr1 cells.	Arginine	89-92	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	141-147
27442705-4	2016	Zinc administrated rats (10mg/kg) were pre-treated with intra-CA1 microinjection of l-arginine in sub-effective dose of 1mug/rat (dorsal hippocampus, vehicle: saline1mul/rat).	Arginine	84-94	carbonic anhydrase 1	Rattus norvegicus	62-65
27603413-7	2016	Once in the nucleus, GnRHa stimulated PAD2 citrullinates histone H3 tail arginine residues at sites 2, 8, and 17 within 30 minutes; however, this effect and PAD2 nuclear localization was blunted by incubation of the cells with the pan-PAD inhibitor, biphenyl-benzimidazole-Cl-amidine.	Arginine	73-81	MMTV LTR integration site 2	Mus musculus	38-42
27603413-7	2016	Once in the nucleus, GnRHa stimulated PAD2 citrullinates histone H3 tail arginine residues at sites 2, 8, and 17 within 30 minutes; however, this effect and PAD2 nuclear localization was blunted by incubation of the cells with the pan-PAD inhibitor, biphenyl-benzimidazole-Cl-amidine.	Arginine	73-81	MMTV LTR integration site 2	Mus musculus	157-161
27571165-8	2016	Finally, we demonstrated that mutation of putatively methylated arginine R65 to alanine decreased MYCN stability by altering phosphorylation at residues serine 62 and threonine 58.	Arginine	64-72	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	98-102
27385405-2	2016	The current study investigates the in vivo effects on energy homeostasis of a 15 nM MC4R antagonist SKY2-23-7, Ac-Trp-DPhe(p-I)-Arg-Trp-NH2, that is a 3700 nM melanocortin-3 receptor (MC3R) antagonist with minimal MC3R and MC4R agonist activity.	Arginine	128-131	melanocortin 4 receptor	Mus musculus	84-88
27448590-4	2016	Remarkably, ELISAs involving selected citrullinated HSP90beta/alpha peptides identified a key epitope corresponding to an internal Arg residue (R502 [HSP90beta]/R510 [HSP90alpha]) that is normally buried within the crystal structure of native/unmodified HSP90.	Arginine	131-134	heat shock protein 90 alpha family class B member 1	Homo sapiens	52-61
27448590-4	2016	Remarkably, ELISAs involving selected citrullinated HSP90beta/alpha peptides identified a key epitope corresponding to an internal Arg residue (R502 [HSP90beta]/R510 [HSP90alpha]) that is normally buried within the crystal structure of native/unmodified HSP90.	Arginine	131-134	heat shock protein 90 alpha family class B member 1	Homo sapiens	150-159
27448590-4	2016	Remarkably, ELISAs involving selected citrullinated HSP90beta/alpha peptides identified a key epitope corresponding to an internal Arg residue (R502 [HSP90beta]/R510 [HSP90alpha]) that is normally buried within the crystal structure of native/unmodified HSP90.	Arginine	131-134	heat shock protein 90 alpha family class A member 1	Homo sapiens	167-177
27448590-4	2016	Remarkably, ELISAs involving selected citrullinated HSP90beta/alpha peptides identified a key epitope corresponding to an internal Arg residue (R502 [HSP90beta]/R510 [HSP90alpha]) that is normally buried within the crystal structure of native/unmodified HSP90.	Arginine	131-134	heat shock protein 90 alpha family class A member 1	Homo sapiens	52-57
27448590-6	2016	Conventional as well as scaled molecular dynamics simulations further demonstrate that citrullination of selected Arg residues leads to progressive disruption of HSP90 tertiary structure, promoting exposure of R502/R510 to PAD modification and subsequent autoantibody binding.	Arginine	114-117	heat shock protein 90 alpha family class A member 1	Homo sapiens	162-167
26923761-1	2016	In inflammatory arthritis peptidyl arginine deiminase (PAD) enzymes can citrullinate arginine residues in extracellular matrix (ECM) proteins, such as collagens and fibronectin.	Arginine	35-43	peptidyl arginine deiminase 4	Homo sapiens	55-58
27339900-6	2016	Specifically, the N(alpha)-terminally acetylated (Nt-acetylated) Ac-AANAT is destroyed through the recognition of its Nt-acetylated N-terminal Met residue by the Ac/N-end rule pathway, whereas the non-Nt-acetylated AANAT is targeted by the Arg/N-end rule pathway, which recognizes the unacetylated N-terminal Met-Leu sequence of rat AANAT.	Arginine	240-243	aralkylamine N-acetyltransferase	Rattus norvegicus	68-73
27339900-6	2016	Specifically, the N(alpha)-terminally acetylated (Nt-acetylated) Ac-AANAT is destroyed through the recognition of its Nt-acetylated N-terminal Met residue by the Ac/N-end rule pathway, whereas the non-Nt-acetylated AANAT is targeted by the Arg/N-end rule pathway, which recognizes the unacetylated N-terminal Met-Leu sequence of rat AANAT.	Arginine	240-243	aralkylamine N-acetyltransferase	Rattus norvegicus	215-220
27339900-6	2016	Specifically, the N(alpha)-terminally acetylated (Nt-acetylated) Ac-AANAT is destroyed through the recognition of its Nt-acetylated N-terminal Met residue by the Ac/N-end rule pathway, whereas the non-Nt-acetylated AANAT is targeted by the Arg/N-end rule pathway, which recognizes the unacetylated N-terminal Met-Leu sequence of rat AANAT.	Arginine	240-243	aralkylamine N-acetyltransferase	Rattus norvegicus	215-220
27339900-7	2016	We also show, by constructing lysine-to-arginine mutants of rat AANAT, that its degradation is mediated by polyubiquitylation of its Lys residue(s).	Arginine	40-48	aralkylamine N-acetyltransferase	Rattus norvegicus	64-69
27452468-1	2016	Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	0-28
21210651-7	2011	The peptide is flanked N-terminally by a single arginine and C-terminally by a common amidation signal, indicating that insulin-like growth factor-binding protein 5 (IGFBP-5) undergoes specific cleavage by a defined set of processing proteases.	Arginine	48-56	insulin-like growth factor binding protein 5	Rattus norvegicus	120-164
21210651-7	2011	The peptide is flanked N-terminally by a single arginine and C-terminally by a common amidation signal, indicating that insulin-like growth factor-binding protein 5 (IGFBP-5) undergoes specific cleavage by a defined set of processing proteases.	Arginine	48-56	insulin-like growth factor binding protein 5	Rattus norvegicus	166-173
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	histone deacetylase 1	Mus musculus	88-109
21339697-3	2011	We found that PtdInsPs, including PI(4,5)P((2)), directly bind to the positively charged Arg(54) of murine NF-L, and this binding promotes NF-L self assembly in vitro.	Arginine	89-92	neurofilament, light polypeptide	Mus musculus	107-111
21339697-3	2011	We found that PtdInsPs, including PI(4,5)P((2)), directly bind to the positively charged Arg(54) of murine NF-L, and this binding promotes NF-L self assembly in vitro.	Arginine	89-92	neurofilament, light polypeptide	Mus musculus	139-143
21339697-5	2011	These results collectively suggest that Arg(54) plays a pivotal role in NF-L self assembly by binding with PtdInsPs.	Arginine	40-43	neurofilament, light polypeptide	Mus musculus	72-76
21159997-6	2011	Second, SNAP and L-arginine were able to increase NCX2 activity, but this effect was prevented by the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ).	Arginine	17-27	solute carrier family 8 member A2	Homo sapiens	50-54
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 4	Homo sapiens	103-108
21127067-8	2011	Finally, by comparing the phosphorylation of an array of 720 peptides, we show that DYRK1A, DYRK2, and DYRK4 differ in their target recognition sequence and that preference for an arginine residue at position P -3 is a feature of DYRK1A but not of DYRK2 and DYRK4.	Arginine	180-188	dual specificity tyrosine phosphorylation regulated kinase 4	Homo sapiens	258-263
21147780-3	2011	Ex vivo data showed that human PCSK9 is inactivated by cleavage at Arg(218)  by the overexpressed convertases furin and PC5/6A.	Arginine	67-70	proprotein convertase subtilisin/kexin type 9	Homo sapiens	31-36
21276933-1	2011	The modification of protein by arginine catalyzed by arginyltransferases (ATE1) described by the Kashina group in this issue shows that arginylation of protein occurs widely in biology and is being recognized as a key regulatory reaction such as phosphorylation of proteins (Wang et al., 2011).	Arginine	31-39	arginyltransferase 1	Homo sapiens	74-78
21273489-2	2011	We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325.	Arginine	217-225	baculoviral IAP repeat containing 3	Homo sapiens	24-28
21273489-2	2011	We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325.	Arginine	217-225	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	182-207
21273489-2	2011	We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK) at arginine 325.	Arginine	217-225	mitogen-activated protein kinase kinase kinase 14	Homo sapiens	209-212
21078669-7	2011	Guided by structural bioinformatics including protein-protein docking, we revealed that the amino acids Arg(63), Lys(70), Lys(101), Glu(138), Asp(139), and Asn(160) engage in intermolecular salt bridges within the anxA5 trimer, which is the basic building block of the two-dimensional network.	Arginine	104-107	annexin A5	Homo sapiens	214-219
21163258-0	2011	An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	121-126
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Arginine	117-125	Cbl proto-oncogene	Homo sapiens	261-266
20832960-1	2011	Botulinum type A toxin (BoNT/A) is defined by its specific endopeptidase cleavage of SNAP25 between Gln(197) and Arg(198) under reducing conditions.	Arginine	113-116	synaptosome associated protein 25	Homo sapiens	85-91
21790217-4	2011	p21 expression was significantly higher in HHUA cells transfected with the proline variant gene than in those transfected with the arginine variant gene.	Arginine	131-139	H3 histone pseudogene 16	Homo sapiens	0-3
20804491-2	2011	A severe phenotype is caused by a missense mutation in a highly conserved arginine residue at position 156 (R156) in K10.	Arginine	74-82	keratin 10	Homo sapiens	117-120
21848229-4	2011	Combined action of Vit C with L-arginine reduced the degree of GM lesions, activity of eNOS and the content of NO in GM whereas the concentration of L-arginine in blood was increased.	Arginine	30-40	vitrin	Rattus norvegicus	19-22
21848229-4	2011	Combined action of Vit C with L-arginine reduced the degree of GM lesions, activity of eNOS and the content of NO in GM whereas the concentration of L-arginine in blood was increased.	Arginine	149-159	vitrin	Rattus norvegicus	19-22
27452468-1	2016	Argininosuccinate synthase 1 (ASS1) is the rate-limiting enzyme for arginine biosynthesis.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	30-34
27452468-3	2016	Starving ASS1-deficient cells of arginine with arginine blockers such as ADI-PEG20 can induce selective lethality and has shown great promise in the clinical setting.	Arginine	33-41	argininosuccinate synthase 1	Homo sapiens	9-13
27452468-7	2016	Upon arginine deprivation, polyamine metabolites are decreased in the ASS1-deficient cells and in plasma isolated from ASS1-deficient mesothelioma patients.	Arginine	5-13	argininosuccinate synthase 1	Homo sapiens	70-74
27507154-8	2016	Intracellular arginine was increased by 18.9% or 13.1% respectively by overexpression of ARG4 or disruption of CAR1, which enhanced yeast tolerance to ethanol stress.	Arginine	14-22	arginase	Saccharomyces cerevisiae S288C	111-115
27507154-9	2016	Moreover, a 41.1% decrease of intracellular arginine was observed in CAR1 overexpressing strain, which made yeast cells keenly sensitive to ethanol.	Arginine	44-52	arginase	Saccharomyces cerevisiae S288C	69-73
27097548-2	2016	Citrullination or deimination, a post-translational modification of protein-bound arginine into citrulline, catalyzed by Ca(2+) dependent peptidylarginine deiminase enzyme (PAD), plays an essential role in physiological processes include gene expression regulation, apoptosis and the plasticity of the central nervous system, while aberrant citrullination can generate new epitopes, thus involving in the initiation and/or progression of autoimmune disorder like MS. Myelin basic protein (MBP) is the major myelin protein and is generally considered to maintain the stability of the myelin sheath.	Arginine	82-90	peptidyl arginine deiminase 4	Homo sapiens	173-176
27478411-1	2016	BACKGROUND: Peptidylarginine deiminase (PAD) post-translationally converts arginine residues to citrulline residues.	Arginine	20-28	peptidyl arginine deiminase 4	Homo sapiens	40-43
27466704-4	2016	Methylation of KCNQ2 channels at 4 arginine residues by Prmt1 enhances PIP2 binding, and Prmt1 depletion lowers PIP2 affinity of KCNQ2 channels and thereby the channel activities.	Arginine	35-43	protein arginine N-methyltransferase 1	Mus musculus	56-61
27466704-6	2016	Collectively, we propose that Prmt1-dependent facilitation of KCNQ-PIP2 interaction underlies the positive regulation of KCNQ activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures.	Arginine	138-146	protein arginine N-methyltransferase 1	Mus musculus	30-35
27459099-16	2016	Arginine-induced genes involved in systemic acquired resistance included PR1, WRKY70, and EDS1.	Arginine	0-8	transmembrane protein 37	Homo sapiens	73-76
27173583-15	2016	Mutation of all six lysine residues to arginine gave partial bypass of a sin3 HDAC mutant, suggesting that Rad50 acetylation is functionally important for Sin3-mediated expansions.	Arginine	39-47	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	107-112
27560991-9	2016	Among the amino acids tested (all in L configuration), arginine, lysine, tryptophan and histidine enhanced residual activity of rCA1 and rCA4.	Arginine	55-63	carbonic anhydrase 1	Rattus norvegicus	128-132
27578112-7	2016	RESULTS: We identified two novel mutations in the LPL gene causing type 1 hyperlipoproteinemia: a two base pair deletion (c.765_766delAG) resulting in a frameshift at position 256 of the protein (p.G256TfsX26) and a nucleotide substitution (c.1211 T &gt; G) resulting in a methionine to arginine substitution (p.M404 R).	Arginine	287-295	lipoprotein lipase	Homo sapiens	50-53
27130798-1	2016	The present study was carried out to find out the effect of leuprolide, a gonadotropin-releasing hormone (GnRH) receptor agonist, on l-arginine induced immunosuppression, and relates with brain and thymus levels of nitric oxide (NO).	Arginine	133-143	gonadotropin releasing hormone receptor	Mus musculus	74-120
27358192-2	2016	One Pol beta mutation that has been identified in tumors, R137Q (arginine to glutamine substitution), has been shown to lower polymerase activity, and impair its DNA repair capacity.	Arginine	65-73	polymerase (DNA directed), beta	Mus musculus	4-12
27335408-4	2016	These high-Pr, GluN2B(+) synapses are evident in arg(-/-) animals as early as postnatal day 21 (P21), a time that precedes any observable defects in synapse or dendritic spine number or structure in arg(-/-) mice.	Arginine	49-52	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	15-21
27335408-4	2016	These high-Pr, GluN2B(+) synapses are evident in arg(-/-) animals as early as postnatal day 21 (P21), a time that precedes any observable defects in synapse or dendritic spine number or structure in arg(-/-) mice.	Arginine	199-202	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	15-21
27335408-5	2016	Using focal glutamate uncaging at individual synapses, we find only a subpopulation of arg(-/-) spines exhibits increased GluN2B-mediated responses at P21.	Arginine	87-90	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	122-128
27072115-5	2016	Additionally, 2 novel PTMs in ITIH3 were identified and included citrullination at arginine-(546) and arginine-(556), and hexosamine at tryptophan-(558).	Arginine	83-91	inter-alpha-trypsin inhibitor heavy chain 3	Homo sapiens	30-35
27072115-5	2016	Additionally, 2 novel PTMs in ITIH3 were identified and included citrullination at arginine-(546) and arginine-(556), and hexosamine at tryptophan-(558).	Arginine	102-110	inter-alpha-trypsin inhibitor heavy chain 3	Homo sapiens	30-35
27013529-5	2016	One of the variants caused an arginine (R) to cysteine (C) change at codon 35 of the ATPase, Ca(2+) transporting, plasma membrane 3 (Atp2b3) gene encoding PMCA3 that has high expression in the cerebellum.	Arginine	30-38	ATPase plasma membrane Ca2+ transporting 3	Rattus norvegicus	133-139
26862997-7	2016	Insulin secretion in response to hyperglycemic clamp and to arginine was impaired.	Arginine	60-68	insulin	Mustela putorius furo	0-7
27569097-1	2016	PURPOSE: To find a possible association between the Mouse Double Minute 2(MDM2) 344T&gt;A, alone and in combination with p53 72 Arg/Pro polymorphism, and resistance to anthracycline-based chemotherapy of breast cancer in Tunisia.	Arginine	128-131	transformation related protein 53, pseudogene	Mus musculus	121-124
27126795-1	2016	Silencing of ODC also led to significantly reduced concentrations of polyamines (putrescine, spermidine and spermine), tyramine and phenolamides (caffeoylputrescine and dicaffeoylspermidine) with concomitant increases in concentrations of amino acids ornithine, arginine, aspartate, glutamate and glutamine.	Arginine	262-270	ornithine decarboxylase	Nicotiana tabacum	13-16
26831650-2	2016	The arginine, one of the major amino acids in grape musts, is metabolized by arginase (encoded by CAR1) to ornithine and urea.	Arginine	4-12	arginase	Saccharomyces cerevisiae S288C	98-102
27017485-10	2016	Furthermore, systemic administration of the miR-141 knock-down the expression of HMGB1 protein and further antagonized the downstream protein Beclin-1, leading to the reduction of autophagosomes and autolysosomes, blockade of the LC3-II level and the increased levels of p62 protein after injection of l-arginine.	Arginine	302-312	beclin 1, autophagy related	Mus musculus	142-150
27010094-7	2016	Genetic analysis revealed a single-base substitution (C&gt;T) at the codon 359 (Arg to STOP) in the 5th exon portion of the antithrombin gene, heterozygote.	Arginine	80-83	serpin family C member 1	Homo sapiens	124-136
26972339-4	2016	Two independent glycine-to-arginine substitutions (G121R and G291R), both affecting key active site loops of PGM1, are found to induce regions of structural disorder, as evidenced by a nearly complete loss of electron density for as many as 23 aa.	Arginine	27-35	phosphoglucomutase 1	Homo sapiens	109-113
26912789-2	2016	We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83.	Arginine	57-65	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	49-53
26912789-2	2016	We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83.	Arginine	57-65	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	160-164
26912789-2	2016	We show that PRMT5 interacts with and methylates ASK1 at arginine residue 89 and thereby negatively regulates its activity by promoting the interaction between ASK1 and Akt and thus phosphorylating ASK1 at serine residue 83.	Arginine	57-65	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	160-164
27051521-1	2016	BACKGROUND: NRD convertase, also termed Nardilysin, is a Zn(++) metalloendopeptidase that specifically cleaves the N-terminus of arginine and lysine residues into dibasic moieties.	Arginine	129-137	nardilysin, N-arginine dibasic convertase, NRD convertase 1	Mus musculus	12-26
27051521-1	2016	BACKGROUND: NRD convertase, also termed Nardilysin, is a Zn(++) metalloendopeptidase that specifically cleaves the N-terminus of arginine and lysine residues into dibasic moieties.	Arginine	129-137	nardilysin, N-arginine dibasic convertase, NRD convertase 1	Mus musculus	40-50
21494411-0	2011	Argininosuccinate synthase: at the center of arginine metabolism.	Arginine	45-53	argininosuccinate synthase 1	Homo sapiens	0-26
26771234-7	2016	Overexpression of USP28 in BR cells enhances c-Myc expression and hence increases ASS1 transcription upon arginine deprivation, and consequently leads to cell survival.	Arginine	106-114	argininosuccinate synthase 1	Homo sapiens	82-86
21494411-2	2011	The importance of this temporal and spatial control of cellular L-arginine is highlighted by the tissue specific roles of argininosuccinate synthase (argininosuccinate synthetase) (EC 6.3.4.5), as the rate-limiting step in the conversion of L-citrulline to L-arginine.	Arginine	64-74	argininosuccinate synthase 1	Homo sapiens	122-148
21494411-2	2011	The importance of this temporal and spatial control of cellular L-arginine is highlighted by the tissue specific roles of argininosuccinate synthase (argininosuccinate synthetase) (EC 6.3.4.5), as the rate-limiting step in the conversion of L-citrulline to L-arginine.	Arginine	257-267	argininosuccinate synthase 1	Homo sapiens	122-148
21494411-3	2011	Since its discovery, the function of argininosuccinate synthase has been linked almost exclusively to hepatic urea production despite the fact that alternative pathways involving argininosuccinate synthase were defined, such as its role in providing arginine for creatine and for polyamine biosynthesis.	Arginine	250-258	argininosuccinate synthase 1	Homo sapiens	37-63
21494411-3	2011	Since its discovery, the function of argininosuccinate synthase has been linked almost exclusively to hepatic urea production despite the fact that alternative pathways involving argininosuccinate synthase were defined, such as its role in providing arginine for creatine and for polyamine biosynthesis.	Arginine	250-258	argininosuccinate synthase 1	Homo sapiens	179-205
21494411-5	2011	Indeed, our knowledge of the number of tissues that manage distinct pools of arginine under the control of argininosuccinate synthase has expanded significantly.	Arginine	77-85	argininosuccinate synthase 1	Homo sapiens	107-133
26836778-7	2016	Moreover, the longer length of the side-chain of residue 495 has a significant effect on the electrostatic interaction between TMC and Arg-503.	Arginine	135-138	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	127-130
27117808-0	2016	A novel mutation affecting the arginine-137 residue of AVPR2 in dizygous twins leads to nephrogenic diabetes insipidus and attenuated urine exosome aquaporin-2.	Arginine	31-39	aquaporin 2	Homo sapiens	148-159
26819073-9	2016	Although the arginine-supplemented diet decreased the mRNA expression level of PPARG in muscle and SAT, it did not influence fat content or fatty acid composition in any of these pig tissues.	Arginine	13-21	peroxisome proliferator activated receptor gamma	Sus scrofa	79-84
26934207-5	2016	Treatment with AR was furthermore shown to promote thermotolerance in a DAF-16- and SIR-2.1-dependent manner, where DAF-16 and SIR-2.1 are homologs of FoxO and SirT1, respectively.	Arginine	15-17	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	72-78
26934207-5	2016	Treatment with AR was furthermore shown to promote thermotolerance in a DAF-16- and SIR-2.1-dependent manner, where DAF-16 and SIR-2.1 are homologs of FoxO and SirT1, respectively.	Arginine	15-17	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	116-122
26934207-6	2016	Taken together, these data suggest that AR is one of the active components of NP and promotes thermotolerance via the activation of DAF-16 and SIR-2.1.	Arginine	40-42	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	132-138
26888112-2	2016	However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial.	Arginine	115-123	adrenoceptor beta 3	Homo sapiens	89-94
26888112-2	2016	However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial.	Arginine	125-128	adrenoceptor beta 3	Homo sapiens	89-94
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	argininosuccinate synthase 1	Homo sapiens	84-88
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	proline dehydrogenase 1	Homo sapiens	109-114
26721385-2	2016	A detailed analysis of the simulation shows that movements of two key arginine side chains between the major groove and the backbone of DNA generate distinct conformational sub-states that each recognize only part of the consensus binding sequence of SKN-1, while the experimentally observed binding specificity results from a time-averaged view of the dynamic recognition occurring within this complex.	Arginine	70-78	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	251-256
25424426-1	2016	AIM: To explore the association between the Arg(972) insulin receptor substrate (IRS)-1 polymorphism (rs1801278) and the risk and disease activity/severity of rheumatoid arthritis (RA).	Arginine	44-47	insulin receptor substrate 1	Homo sapiens	53-87
25424426-2	2016	METHOD: We genotyped the Arg(972) IRS-1 polymorphism in 871 pairs of age-, sex-, body mass index-, residence area- and current smoking status-matched RA patients and controls.	Arginine	25-28	insulin receptor substrate 1	Homo sapiens	34-39
25424426-4	2016	RESULTS: The AA (homozygous Arg(972) IRS-1) and GA (heterozygous Arg(972) IRS-1) genotypes were significantly associated with high risk of RA with or without adjustment for comorbidities (P &lt; 0.001).	Arginine	65-68	insulin receptor substrate 1	Homo sapiens	74-79
25424426-7	2016	CONCLUSION: The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of RA, and therefore may be a potential prognostic factor for RA.	Arginine	16-19	insulin receptor substrate 1	Homo sapiens	25-30
27010901-2	2016	The C-terminal Arg-Phe-NH2 of PrRP is crucial for its biological activity.	Arginine	15-18	prolactin releasing hormone	Rattus norvegicus	30-34
26601957-9	2016	These data provide new evidence demonstrating that amino acid sequence Leu(480)-Gln(481): 1) is crucial for proper recognition of the fVa-dependent site(s) for fXa within prothrombinase on FII, required for efficient initial cleavage of FII at Arg(320); and 2) is compulsory for appropriate tethering of fV, fVIII, and protein C required for their timely activation by IIa.	Arginine	244-247	protein kinase cAMP-dependent type I regulatory subunit alpha	Rattus norvegicus	369-372
26657730-8	2016	We show that BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239.	Arginine	102-110	BTG anti-proliferation factor 1	Mus musculus	13-17
26657730-8	2016	We show that BTG1 interacts with ATF4 and positively modulates its activity by recruiting the protein arginine methyl transferase PRMT1 to methylate ATF4 on arginine residue 239.	Arginine	102-110	protein arginine N-methyltransferase 1	Mus musculus	130-135
26839743-1	2016	The non-protein amino acid L-canavanine (L-CAV), an antimetabolite of L-arginine (L-ARG), can alter the 3D conformation of proteins when incorporated into a protein instead of L-ARG.	Arginine	70-80	caveolin 2	Homo sapiens	43-46
26839743-1	2016	The non-protein amino acid L-canavanine (L-CAV), an antimetabolite of L-arginine (L-ARG), can alter the 3D conformation of proteins when incorporated into a protein instead of L-ARG.	Arginine	82-87	caveolin 2	Homo sapiens	43-46
26839743-1	2016	The non-protein amino acid L-canavanine (L-CAV), an antimetabolite of L-arginine (L-ARG), can alter the 3D conformation of proteins when incorporated into a protein instead of L-ARG.	Arginine	176-181	caveolin 2	Homo sapiens	43-46
26839743-3	2016	The deprivation of L-ARG in the culture medium enhances the response of cells to L-CAV.	Arginine	19-24	caveolin 2	Homo sapiens	83-86
27643579-4	2016	This mutant, created by the deletion of arginine 67 in RPS19, exhibits craniofacial, skeletal, and brain abnormalities, accompanied by various neurobehavioural malfunctions.	Arginine	40-48	ribosomal protein S19	Homo sapiens	55-60
26763441-0	2016	MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCdelta/p38delta Signaling.	Arginine	47-55	WD repeat domain 77	Homo sapiens	0-5
26763441-4	2016	This protein interacts with a cofactor, methylosome protein 50 (MEP50), and symmetrically dimethylates arginine eight of histone 3 (H3R8me2s) and arginine three of histone 4 (H4R3me2s) to silence gene expression.	Arginine	103-111	WD repeat domain 77	Homo sapiens	40-62
26763441-4	2016	This protein interacts with a cofactor, methylosome protein 50 (MEP50), and symmetrically dimethylates arginine eight of histone 3 (H3R8me2s) and arginine three of histone 4 (H4R3me2s) to silence gene expression.	Arginine	103-111	WD repeat domain 77	Homo sapiens	64-69
26763441-4	2016	This protein interacts with a cofactor, methylosome protein 50 (MEP50), and symmetrically dimethylates arginine eight of histone 3 (H3R8me2s) and arginine three of histone 4 (H4R3me2s) to silence gene expression.	Arginine	146-154	WD repeat domain 77	Homo sapiens	40-62
26763441-4	2016	This protein interacts with a cofactor, methylosome protein 50 (MEP50), and symmetrically dimethylates arginine eight of histone 3 (H3R8me2s) and arginine three of histone 4 (H4R3me2s) to silence gene expression.	Arginine	146-154	WD repeat domain 77	Homo sapiens	64-69
26763441-7	2016	This is associated with increased arginine dimethylation of hINV gene-associated H3/H4.	Arginine	34-42	leishmanolysin like peptidase	Homo sapiens	60-64
26763441-9	2016	We propose that PRMT5/MEP50-dependent methylation is an epigenetic mechanism that assists in silencing of hINV expression, and that PKCdelta signaling activates gene expression by directly activating transcription and by suppressing PRMT5/MEP50-dependent arginine dimethylation of promoter-associated histones.	Arginine	255-263	WD repeat domain 77	Homo sapiens	22-27
26763441-9	2016	We propose that PRMT5/MEP50-dependent methylation is an epigenetic mechanism that assists in silencing of hINV expression, and that PKCdelta signaling activates gene expression by directly activating transcription and by suppressing PRMT5/MEP50-dependent arginine dimethylation of promoter-associated histones.	Arginine	255-263	leishmanolysin like peptidase	Homo sapiens	106-110
27110069-5	2016	The results showed that arginine reduced the LPS-induced production like IL-1beta, IL-6, TNF-alpha, and iNOS.	Arginine	24-32	tumor necrosis factor	Bos taurus	89-98
26188014-3	2016	IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG).	Arginine	134-137	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	146-150
26721863-4	2016	RZ-1B and RZ-1C were localized to nuclear speckles and interacted with a spectrum of serine/arginine-rich (SR) proteins through their C termini.	Arginine	92-100	RNA-binding (RRM/RBD/RNP motifs) family protein with retrovirus zinc finger-like domain-containing protein	Arabidopsis thaliana	0-5
21904558-9	2011	The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.	Arginine	4-12	HNP1	Homo sapiens	19-24
21904558-9	2011	The arginine 14 of HNP-1 modified by the ADP-ribose is in some cases processed into ornithine, perhaps representing a different modality in the regulation of HNP-1 activities.	Arginine	4-12	HNP1	Homo sapiens	158-163
26645987-3	2015	We have recently shown that MASP-1 activates prothrombin and identified arginine (R) 155, R271, and R393 as potential cleavage sites.	Arginine	72-80	MBL associated serine protease 1	Homo sapiens	28-34
22132161-6	2011	Using several chromogenic substrates and serine proteinase inhibitors, we demonstrate that ISP1 exhibits trypsin-like substrate specificity, having a preference for lysine over arginine at the P1 position.	Arginine	177-185	protease, serine 28	Mus musculus	91-95
26491198-7	2015	CAT2 contributes to the transport of l-Arg in MDSCs and is an important regulator of MDSC suppressive function.	Arginine	37-42	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-4
26446016-2	2015	The additions to the HBc positively charged arginine-rich C-terminal (CT) domain are usually not exposed on the VLP surface.	Arginine	44-52	keratin 88, pseudogene	Homo sapiens	21-24
21210565-0	2004	(125)I-Labeled murine anti-CD20 antigen monoclonal antibody NuB2 conjugated to one or three octaarginine (maleimide-(6-aminocaproic acid)2-(D-Arg)8-(D-Tyr)) peptide chains The B cell differentiation antigen CD20 is a transmembrane, non-glycosylated, hydrophobic protein that is characteristically expressed in &gt;90% of non-Hodgkin lymphoma tumors.	Arginine	141-145	membrane-spanning 4-domains, subfamily A, member 1	Mus musculus	27-31
20937814-3	2010	Although autocatalytic zymogen processing of PCSK9 occurs at Gln(152) , here we show that human PCSK9 can be further cleaved in its N-terminal prosegment at Arg(46)  by an endogenous enzyme of insect High Five cells and by a cellular mammalian protease, yielding an ~4-fold enhanced activity.	Arginine	157-160	proprotein convertase subtilisin/kexin type 9	Homo sapiens	96-101
26555036-7	2015	RESULTS: The close proximity of Arg/Lys amino acids and a proline two residues N-terminal to the phosphorylated residue both improve recognition of the substrate by CDK5.	Arginine	32-35	cyclin dependent kinase 5	Homo sapiens	165-169
20937814-6	2010	We also show that upon short exposure to pH values 6.5 to 5.5, an ~2.5-fold increase in PCSK9 activity on total and cell surface LDLR occurs, and PCSK9 undergoes a second cleavage at Arg(248), generating a two-chain PCSK9-DeltaN(248).	Arginine	183-186	proprotein convertase subtilisin/kexin type 9	Homo sapiens	88-93
20937814-6	2010	We also show that upon short exposure to pH values 6.5 to 5.5, an ~2.5-fold increase in PCSK9 activity on total and cell surface LDLR occurs, and PCSK9 undergoes a second cleavage at Arg(248), generating a two-chain PCSK9-DeltaN(248).	Arginine	183-186	proprotein convertase subtilisin/kexin type 9	Homo sapiens	146-151
20937814-6	2010	We also show that upon short exposure to pH values 6.5 to 5.5, an ~2.5-fold increase in PCSK9 activity on total and cell surface LDLR occurs, and PCSK9 undergoes a second cleavage at Arg(248), generating a two-chain PCSK9-DeltaN(248).	Arginine	183-186	proprotein convertase subtilisin/kexin type 9	Homo sapiens	146-151
26062933-1	2015	PURPOSE: The aim of this study was to investigate the biodistribution of 2-fluoropropionyl-labeled PEGylated dimeric arginine-glycine-aspartic acid (RGD) peptide (PEG3-E[c{RGDyk}]2) ((18)F-FPPRGD2) in cancer patients and to compare its uptake in malignant lesions with (18)F-FDG uptake.	Arginine	117-125	paternally expressed 3	Homo sapiens	163-167
20923763-1	2010	The free form of human cytoplasmic arginyl-tRNA synthetase (hcArgRS) is hypothesized to participate in ubiquitin-dependent protein degradation by offering arginyl-tRNA(Arg) to arginyl-tRNA transferase (ATE1).	Arginine	62-65	arginyltransferase 1	Homo sapiens	202-206
26641049-8	2015	Total numbers of piglets born ( = 0.084) and born alive ( = 0.080) per litter tended to be higher for sows supplemented with arginine between d 1 and 14 of gestation (T2) than for control sows (T1).	Arginine	125-133	iodothyronine deiodinase 1	Sus scrofa	142-152
21143836-3	2010	We recently reported the use of a synthetic compound, 2-guanidine-4-methylquinazoline (GMQ), to identify a novel nonproton sensing domain in the ASIC3 channel, and proposed that, based on its structural similarity with GMQ, the arginine metabolite agmatine (AGM) may be an endogenous nonproton ligand for ASIC3 channels.	Arginine	228-236	acid sensing ion channel subunit 3	Homo sapiens	145-150
21143836-3	2010	We recently reported the use of a synthetic compound, 2-guanidine-4-methylquinazoline (GMQ), to identify a novel nonproton sensing domain in the ASIC3 channel, and proposed that, based on its structural similarity with GMQ, the arginine metabolite agmatine (AGM) may be an endogenous nonproton ligand for ASIC3 channels.	Arginine	228-236	acid sensing ion channel subunit 3	Homo sapiens	305-310
26539208-4	2015	Here, we identified a novel mutation c.1402C&gt;T in AFG3L2, modifying the arginine 468 in cysteine in an evolutionary highly conserved arginine-finger motif, in a family with optic atrophy and mild intellectual disability.	Arginine	75-83	AFG3 like matrix AAA peptidase subunit 2	Homo sapiens	53-59
20880257-2	2010	The u-PAR may exist in a glycophosphatidylinositol-anchored and in a soluble form (soluble u-PAR [Su-PAR]), both including the chemotactic Ser88 -Arg-Ser-Arg-Tyr92 internal sequence.	Arginine	146-149	plasminogen activator, urokinase receptor	Homo sapiens	4-9
20880257-2	2010	The u-PAR may exist in a glycophosphatidylinositol-anchored and in a soluble form (soluble u-PAR [Su-PAR]), both including the chemotactic Ser88 -Arg-Ser-Arg-Tyr92 internal sequence.	Arginine	154-157	plasminogen activator, urokinase receptor	Homo sapiens	4-9
26466368-6	2015	Also degradation of substrates with strong affinity to Ubr1 like those containing the type 1 N-degron arginine is not affected by the absence of the Hsp31 chaperone family.	Arginine	102-110	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	55-59
20541608-8	2010	In order to assure that FMRP retained activity throughout the process, we used fluorescence spectroscopy to assay the binding activity of the FMRP arginine-glycine-glycine box for the semaphorin 3F mRNA and confirmed that FMRP remained active.	Arginine	147-155	semaphorin 3F	Homo sapiens	184-197
26227967-4	2015	Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA.	Arginine	83-91	arginine/serine-rich splicing factor 35	Arabidopsis thaliana	114-118
20607758-1	2010	BACKGROUND: E-selectin, an intercellular adhesion molecule that plays important roles in metastasis of tumor cells, has a polymorphism in exon 4 that results in the substitution of a serine by an arginine within the extracellular domain of the receptor, which increases its affinity for ligands.	Arginine	196-204	selectin E	Homo sapiens	12-22
20484304-3	2010	L-Arg is synthesized by renal argininosuccinate synthase/argininosuccinate lyase (ASS/ASL) and then either consumed within the kidney by arginase II or NOS or released into the circulation.	Arginine	0-5	argininosuccinate lyase	Rattus norvegicus	57-80
21060813-2	2010	To address this fundamental issue, we have identified four distinct HBc localization signals in the arginine rich domain (ARD) of HBc, using immunofluorescence confocal microscopy and fractionation/Western blot analysis.	Arginine	100-108	keratin 88, pseudogene	Homo sapiens	68-71
21060813-2	2010	To address this fundamental issue, we have identified four distinct HBc localization signals in the arginine rich domain (ARD) of HBc, using immunofluorescence confocal microscopy and fractionation/Western blot analysis.	Arginine	100-108	keratin 88, pseudogene	Homo sapiens	130-133
26227967-4	2015	Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA.	Arginine	83-91	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	123-127
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	H3 histone pseudogene 16	Homo sapiens	236-239
20923641-6	2010	We further characterized a mutation, Cx50N9R, where the Asn (N) at the ninth position of Cx50 was replaced by the corresponding Arg (R) at Cx36.	Arginine	128-131	gap junction protein, alpha 8	Mus musculus	37-41
26413482-6	2015	However, hepatocytes can produce its own glucose and arginine through galactokinase and ornithine transcarbamylase, respectively.	Arginine	53-61	ornithine transcarbamylase	Homo sapiens	88-114
20923641-9	2010	Our data suggest that the NT of Cx50 is critical for both the V(j)-gating and the gamma(j), and the introduction of a positively charged Arg at the ninth position reduced the G(min) with a correlated disappearance of the substate at the single channel level.	Arginine	137-140	gap junction protein, alpha 8	Mus musculus	32-36
20634695-5	2010	Work studying molecular mechanisms indicates that 90% of the known mutations causing hypokalaemic periodic paralysis (HypoPP) result in loss of positively charged arginine residues in the S4 segments of either SCN4A or CACNA1S, possibly creating a gating-pore current that may be important in the pathogenesis of HypoPP.	Arginine	163-171	sodium voltage-gated channel alpha subunit 4	Homo sapiens	210-215
26221041-8	2015	Reversible arginine methylation of TRAF6 by the opposing effects of PRMT1 and JMJD6 is, therefore, a novel mechanism for regulation of innate immune pathways.	Arginine	11-19	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	78-83
20647003-6	2010	Furthermore, overexpression of a methylation-resistant rpS2, whose methylated arginine residues were deleted, produced phenotypes that were similar to those associated with PRMT3 downregulation.	Arginine	78-86	ribosomal protein S2	Rattus norvegicus	55-59
26142902-4	2015	rLap1 showed the highest activity against Arg-pNA and then Leu-, Lys-, Met-, and Phe-pNA.	Arginine	42-45	alanyl aminopeptidase, membrane	Rattus norvegicus	0-5
20850011-5	2010	This function of Drp1 is independent of its GTPase activity and relies on arginine 247 and the presence of cardiolipin in membranes.	Arginine	74-82	dynamin 1 like	Homo sapiens	17-21
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	368-371	H3 histone pseudogene 16	Homo sapiens	48-51
22444698-0	2010	Dietary protein, energy and arginine affect LAT1 expression in forebrain white matter differently.	Arginine	28-36	L-type amino acid transporter 1	Sus scrofa	44-48
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	368-371	H3 histone pseudogene 16	Homo sapiens	48-51
22444698-3	2010	The results showed that LAT1 expression in forebrain was sensitive to different levels of CP, energy and arginine.	Arginine	105-113	L-type amino acid transporter 1	Sus scrofa	24-28
22444698-4	2010	On the basis of Western blot analysis, a lower level of LAT1 presented in the brain tissues of pigs fed the low dietary CP diet (P &lt; 0.05), a higher level were found in pigs fed the higher CP diet, with moderate to intense staining seen in pigs fed the diet plus 1% arginine.	Arginine	269-277	L-type amino acid transporter 1	Sus scrofa	56-60
26023227-3	2015	Compared with Pla, plasma Arg concentration was increased by a similar magnitude with Arg and Cit supplementation, but plasma Cit concentration was only increased (P &lt; 0.001) with Cit supplementation.	Arginine	26-29	citron rho-interacting serine/threonine kinase	Homo sapiens	94-97
22444698-5	2010	In contrast, pigs fed the control-energy diet had weak LAT1 expression, and those fed the diet supplemented with 1% arginine showed lowest LAT1 expression (P &lt; 0.05).	Arginine	116-124	L-type amino acid transporter 1	Sus scrofa	139-143
22444698-6	2010	These results showed that LAT1 was highly expressed in the forebrain, and expression of LAT1 was affected by dietary protein, energy and arginine differently.	Arginine	137-145	L-type amino acid transporter 1	Sus scrofa	26-30
22444698-6	2010	These results showed that LAT1 was highly expressed in the forebrain, and expression of LAT1 was affected by dietary protein, energy and arginine differently.	Arginine	137-145	L-type amino acid transporter 1	Sus scrofa	88-92
26100624-7	2015	The probability of coiled coil dimer formation computed for RetGC1/NPRA chimeras, even those incapable of binding GCAP, remained high, and functional complementation tests showed that the RetGC1 active site, which requires dimerization of the cyclase, was formed even when Met(823) or Arg(822) was mutated.	Arginine	285-288	guanylate cyclase 2D, retinal	Homo sapiens	188-194
20180707-3	2010	In this paper we describe a 17-year-old girl affected by ectrodactyly-ectodermal dysplasia-clefting syndrome with a de novo p63 mutation that predicts a heterozygous missense substitution (arginine to tryptophan substitution caused by a cytosine to thymine transition) at the amino acid 304 (R304W) of the p63 DNA-binding domain.	Arginine	189-197	tumor protein p63	Homo sapiens	124-127
20180707-3	2010	In this paper we describe a 17-year-old girl affected by ectrodactyly-ectodermal dysplasia-clefting syndrome with a de novo p63 mutation that predicts a heterozygous missense substitution (arginine to tryptophan substitution caused by a cytosine to thymine transition) at the amino acid 304 (R304W) of the p63 DNA-binding domain.	Arginine	189-197	tumor protein p63	Homo sapiens	306-309
26100624-8	2015	These results directly demonstrate that the interface for GCAP binding on RetGC1 requires not only the kinase homology region but also directly involves the dimerization domain and especially its portion containing Arg(822) and Met(823).	Arginine	215-218	guanylate cyclase 2D, retinal	Homo sapiens	74-80
20659974-0	2010	Arginine methylation of SmB is required for Drosophila germ cell development.	Arginine	0-8	Small ribonucleoprotein particle protein SmB	Drosophila melanogaster	24-27
20659974-3	2010	In this study, a tissue-specific function of arginine methylation of the SmB protein was identified in Drosophila.	Arginine	45-53	Small ribonucleoprotein particle protein SmB	Drosophila melanogaster	73-76
20659974-5	2010	The pole plasm localisation of SmB requires the methylation of arginine residues in its RG repeats by the Capsuleen-Valois methylosome complex.	Arginine	63-71	Small ribonucleoprotein particle protein SmB	Drosophila melanogaster	31-34
25960296-3	2015	GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin alpha subtypes (alpha1, alpha2 and alpha4).	Arginine	57-65	adrenoceptor alpha 1D	Homo sapiens	120-126
26185611-8	2015	The prevalence of mutant alleles of hOGG1 gene, XRCC1 gene (codon 280 Arg&gt;His) were found to be significantly higher among SCD patients as compared to controls.	Arginine	70-73	8-oxoguanine DNA glycosylase	Homo sapiens	36-41
26113532-1	2015	In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.	Arginine	239-247	argininosuccinate synthase 1	Homo sapiens	129-159
26113532-1	2015	In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.	Arginine	239-247	argininosuccinate synthase 1	Homo sapiens	161-165
26113532-1	2015	In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.	Arginine	266-274	argininosuccinate synthase 1	Homo sapiens	129-159
26113532-1	2015	In this issue of Blood, Miraki-Moud et al demonstrate that the majority of acute myeloid leukemias (AMLs) have low expression of argininosuccinate synthetase-1 (ASS1), rendering AML cell lines and primary AML blasts dependent on exogenous arginine and sensitized to arginine deprivation.	Arginine	266-274	argininosuccinate synthase 1	Homo sapiens	161-165
26085034-6	2015	Individuals over 50 years of age and those with high dietary arginine consumption had increased basal expression of CyclinD1, AXIN2, cMYC and CD133 (p value range 0   04 to &lt;0   001) that, following grape ingestion, were reduced to levels seen in younger participants.The reduction in Wnt signaling and mucosal proliferation seen following short-term ingestion of 1/3-1 lb (0.15-0.45 kg) of grapes per day may reduce the risk of mutational events that can facilitate colon carcinogenesis.	Arginine	61-69	axin 2	Homo sapiens	126-131
26085034-6	2015	Individuals over 50 years of age and those with high dietary arginine consumption had increased basal expression of CyclinD1, AXIN2, cMYC and CD133 (p value range 0   04 to &lt;0   001) that, following grape ingestion, were reduced to levels seen in younger participants.The reduction in Wnt signaling and mucosal proliferation seen following short-term ingestion of 1/3-1 lb (0.15-0.45 kg) of grapes per day may reduce the risk of mutational events that can facilitate colon carcinogenesis.	Arginine	61-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	133-137
26309678-7	2015	Compared Arg/Arg genotype, the risk of cisplatin resistance in patients with Arp/Trp genotype of XRCC1 gene was increased by 6.701 times (95% CI: 1.464~30.732, P&lt;0.05).	Arginine	9-12	cysteine rich secretory protein 1	Homo sapiens	77-80
26309678-7	2015	Compared Arg/Arg genotype, the risk of cisplatin resistance in patients with Arp/Trp genotype of XRCC1 gene was increased by 6.701 times (95% CI: 1.464~30.732, P&lt;0.05).	Arginine	13-16	cysteine rich secretory protein 1	Homo sapiens	77-80
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	55-58
25795782-4	2015	This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4/VAV1/RAC1 NADPH oxidase complex.	Arginine	37-40	neutrophil cytosolic factor 4	Homo sapiens	99-103
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	neutrophil cytosolic factor 4	Homo sapiens	42-46
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	neutrophil cytosolic factor 4	Homo sapiens	164-168
25855358-7	2015	Structural studies revealed that the self-peptide-HLA-B*18:01 complex is a structural mimic of the EBV peptide-HLA-B*18:01 complex, and that the strong antiviral T cell response is primarily dependent on the alanine/arginine mismatch at position 7.	Arginine	216-224	major histocompatibility complex, class I, B	Homo sapiens	50-55
25945972-6	2015	Furthermore, we also identified an Arg-Asp/Glu-Glu-Arg salt-bridge network and the corresponding loop (to position the second Asp/Glu residue) critical for the LN1/2-binding preference.	Arginine	35-38	phytanoyl-CoA 2-hydroxylase	Homo sapiens	160-163
25945972-6	2015	Furthermore, we also identified an Arg-Asp/Glu-Glu-Arg salt-bridge network and the corresponding loop (to position the second Asp/Glu residue) critical for the LN1/2-binding preference.	Arginine	51-54	phytanoyl-CoA 2-hydroxylase	Homo sapiens	160-163
25946048-4	2015	Here we show that Abl family of non-receptor tyrosine kinases, comprised of Abl (ABL1) and Arg (ABL2), are activated downstream of the Met receptor, and that inhibition of Abl kinases dramatically suppresses HGF-induced cell scattering and tubulogenesis.	Arginine	91-94	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	96-100
25682972-17	2015	CONCLUSION: L-Arginine exerts its nephro- and cardio-protective potential in EG-induced urolithiasis in uninephrectomized hypertensive rats via modulation of KIM-1, NGAL, eNOS, and iNOs mRNA expression.	Arginine	12-22	hepatitis A virus cellular receptor 1	Rattus norvegicus	158-163
25704252-4	2015	In this study, we investigated the number and position of HJV cleavage sites by mutagenizing arginine residues (R), potential TMPRSS6 targets, to alanine (A).	Arginine	93-101	hemojuvelin BMP co-receptor	Homo sapiens	58-61
25694433-2	2015	beta1 integrins signal through the Abl2/Arg (Abl-related gene) nonreceptor tyrosine kinase to control fibroblast cell motility, neuronal dendrite morphogenesis and stability, and cancer cell invasiveness, but the molecular mechanisms by which integrin beta1 activates Arg are unknown.	Arginine	40-43	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	35-39
25520183-2	2015	Citrullinations are the conversion of arginine to citrulline by peptidylarginine deiminase (PAD) enzymes, which affect protein properties.	Arginine	38-46	peptidyl arginine deiminase 4	Homo sapiens	64-90
25588829-6	2015	Deacetylase inhibition is sufficient for Net1A relocalization outside the nucleus, and replacement of the N-terminal acetylation sites with arginine residues prevents cytoplasmic accumulation of Net1A caused by deacetylase inhibition or EGF stimulation.	Arginine	140-148	neuroepithelial cell transforming 1	Homo sapiens	195-200
25567351-7	2015	Knocking-down ASS1 reversed the ability of L-citrulline to rescue GBM cells, further illustrating the dependence of arginine auxotrophy on ASS1 expression.	Arginine	116-124	argininosuccinate synthase 1	Homo sapiens	14-18
25567351-7	2015	Knocking-down ASS1 reversed the ability of L-citrulline to rescue GBM cells, further illustrating the dependence of arginine auxotrophy on ASS1 expression.	Arginine	116-124	argininosuccinate synthase 1	Homo sapiens	139-143
25501501-1	2015	Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, NaV1.5.	Arginine	0-8	sodium voltage-gated channel alpha subunit 5	Homo sapiens	152-158
25501501-2	2015	We show that NaV1.5 R513 methylation decreases S516 phosphorylation rate by 4 orders of magnitude, the first evidence of protein kinase A inhibition by arginine methylation.	Arginine	152-160	sodium voltage-gated channel alpha subunit 5	Homo sapiens	13-19
25468444-3	2015	IGFBP-1 and IGFBP-2 have a C-terminal Arg-Gly-Asp (RGD) sequence, and IGFBP-1 has been shown by others to stimulate migration through binding of its RGD sequence to alpha5beta1 integrin.	Arginine	38-41	insulin like growth factor binding protein 1	Homo sapiens	0-7
25522883-0	2015	Unusual pairing between assistants: interaction of the twin-arginine system-specific chaperone DmsD with the chaperonin GroEL.	Arginine	60-68	chaperonin GroEL	Escherichia coli	109-125
25488663-8	2015	The importance of the Arg(102)-Glu(1032) salt bridge was determined using surface plasmon resonance to monitor the binding of wild-type C3d(E1032) and mutant C3d(A1032) to immobilized C3c.	Arginine	22-25	endogenous retrovirus group K member 13	Homo sapiens	136-139
20659974-8	2010	These results demonstrate a crucial role of arginine methylation in directing the subcellular localisation of SmB and that this modification contributes specifically to the establishment and development of germ cells.	Arginine	44-52	Small ribonucleoprotein particle protein SmB	Drosophila melanogaster	110-113
25488663-8	2015	The importance of the Arg(102)-Glu(1032) salt bridge was determined using surface plasmon resonance to monitor the binding of wild-type C3d(E1032) and mutant C3d(A1032) to immobilized C3c.	Arginine	22-25	endogenous retrovirus group K member 13	Homo sapiens	158-161
25531508-3	2015	In this study, we examined the Arg finger catalysis by single-molecule measurements for a mutant of F1 in which the Arg finger is substituted with an unnatural amino acid of a lysine analogue, 2,7-diaminoheptanoic acid (Lyk).	Arginine	31-34	IL2 inducible T cell kinase	Homo sapiens	220-223
20827398-1	2010	Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	35-40
25531508-4	2015	The use of Lyk, of which the side chain is elongated by one CH2 unit so that its chain length to the terminal nitrogen of amine is set to be equal to that of arginine, allowed us to resolve key chemical factors in the Arg finger catalysis, i.e., chain length matching and chemical properties of the terminal groups.	Arginine	158-166	IL2 inducible T cell kinase	Homo sapiens	11-14
25531508-4	2015	The use of Lyk, of which the side chain is elongated by one CH2 unit so that its chain length to the terminal nitrogen of amine is set to be equal to that of arginine, allowed us to resolve key chemical factors in the Arg finger catalysis, i.e., chain length matching and chemical properties of the terminal groups.	Arginine	218-221	IL2 inducible T cell kinase	Homo sapiens	11-14
25604483-4	2015	First, we show, by in vitro kinase assays, that previously identified non-S/T-P motifs all harbour one or more C-terminal Arg/Lys residues essential for their phosphorylation by Cdk1.	Arginine	122-125	cyclin dependent kinase 1	Homo sapiens	178-182
20695527-1	2010	N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than ornithine transcarbamylase (OTCase), is the essential carbamylase enzyme in the arginine biosynthesis of several plant and human pathogens.	Arginine	141-149	ornithine transcarbamylase	Homo sapiens	11-37
20695527-1	2010	N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than ornithine transcarbamylase (OTCase), is the essential carbamylase enzyme in the arginine biosynthesis of several plant and human pathogens.	Arginine	141-149	ornithine transcarbamylase	Homo sapiens	61-87
20695527-1	2010	N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than ornithine transcarbamylase (OTCase), is the essential carbamylase enzyme in the arginine biosynthesis of several plant and human pathogens.	Arginine	141-149	ornithine transcarbamylase	Homo sapiens	40-46
25604483-5	2015	Second, using Arg/Lys-scanning oriented peptide libraries, we demonstrate that Cdk1 phosphorylates a minimal sequence S/T-X-X-R/K and more favorable sequences (P)-X-S/T-X-[R/K](2-5) as its non-S/T-P consensus motifs.	Arginine	14-17	cyclin dependent kinase 1	Homo sapiens	79-83
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Arginine	140-143	major histocompatibility complex, class I, B	Homo sapiens	23-28
20648673-2	2010	Peptidylarginine deiminase 4 (PAD4), which mediates histone deimination by converting arginine residues into citrulline residues, is involved in the repression of gene transcription.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
20648673-5	2010	Deimination of the H2A/H2B dimer by PAD4 indicated that the mass of H2A increased 2.7 Da, suggesting that two or three Arg residues of H2A were deiminated.	Arginine	119-122	peptidyl arginine deiminase 4	Homo sapiens	36-40
25480565-5	2015	Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the conformation of Glu(76), primarily through a salt bridge between Arg(83) and Glu(76).	Arginine	140-143	major histocompatibility complex, class I, B	Homo sapiens	36-41
25313473-5	2015	Our findings demonstrated that in all of the investigated compounds, the NPY(32-36)C-terminal fragment (Thr(32)-Arg(33)-Gln(34)-Arg(35)-Tyr(36)NH2) was involved in the adsorption process onto metal substrate.	Arginine	112-115	neuropeptide Y	Homo sapiens	73-76
20519199-4	2010	To this purpose, we fused the yRAD52 cDNA to the arginine-rich domain of the TAT protein of HIV (tat11) that is known to permeate the cell membranes.	Arginine	49-57	recombinase RAD52	Saccharomyces cerevisiae S288C	30-36
25313473-5	2015	Our findings demonstrated that in all of the investigated compounds, the NPY(32-36)C-terminal fragment (Thr(32)-Arg(33)-Gln(34)-Arg(35)-Tyr(36)NH2) was involved in the adsorption process onto metal substrate.	Arginine	128-131	neuropeptide Y	Homo sapiens	73-76
20660867-10	2010	The other twins had an R307C mutation, the first EA1 mutation to affect an arginine residue in the voltage-sensor domain.	Arginine	75-83	potassium voltage-gated channel subfamily A member 1	Homo sapiens	49-52
25491103-1	2015	Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways.	Arginine	23-26	bone morphogenetic protein 1	Homo sapiens	208-211
20587514-1	2010	The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein.	Arginine	111-119	transformation related protein 53, pseudogene	Mus musculus	4-7
25521377-0	2014	Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.	Arginine	18-26	RAN, member RAS oncogene family	Homo sapiens	27-30
25392530-2	2014	Airway epithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to arginines 14 and 24 of HNP-1.	Arginine	32-40	HNP1	Homo sapiens	162-167
21037969-3	2010	FBD is caused by a stop to Arg mutation in the BRI2 gene, generating de novo created amyloid molecule ABri which accumulates in FBD brains but is not present in the normal population.	Arginine	27-30	integral membrane protein 2B	Homo sapiens	47-51
21037969-3	2010	FBD is caused by a stop to Arg mutation in the BRI2 gene, generating de novo created amyloid molecule ABri which accumulates in FBD brains but is not present in the normal population.	Arginine	27-30	integral membrane protein 2B	Homo sapiens	102-106
25392530-2	2014	Airway epithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to arginines 14 and 24 of HNP-1.	Arginine	139-148	HNP1	Homo sapiens	162-167
25392530-7	2014	Thus, arginines 14 and 24, which can be ADP ribosylated by ART1, are critical to the regulation of the cytotoxic and antibacterial effects of HNP-1.	Arginine	6-15	HNP1	Homo sapiens	142-147
25486018-0	2014	Pharmacological PPARalpha activation markedly alters plasma turnover of the amino acids glycine, serine and arginine in the rat.	Arginine	108-116	peroxisome proliferator activated receptor alpha	Rattus norvegicus	16-25
20423330-6	2010	Mutation of Lys134 of LDB1 to arginine blocks the formation of mono-ubiquitinated LDB1 and surprisingly also increases LDB1 protein expression in HEK-293 cells.	Arginine	30-38	LIM domain binding 1	Homo sapiens	22-26
20423330-6	2010	Mutation of Lys134 of LDB1 to arginine blocks the formation of mono-ubiquitinated LDB1 and surprisingly also increases LDB1 protein expression in HEK-293 cells.	Arginine	30-38	LIM domain binding 1	Homo sapiens	82-86
20423330-6	2010	Mutation of Lys134 of LDB1 to arginine blocks the formation of mono-ubiquitinated LDB1 and surprisingly also increases LDB1 protein expression in HEK-293 cells.	Arginine	30-38	LIM domain binding 1	Homo sapiens	82-86
25486018-12	2014	This suggests that PPARalpha has an important role in modulating serine, glycine and arginine de novo synthesis.	Arginine	85-93	peroxisome proliferator activated receptor alpha	Rattus norvegicus	19-28
25320354-2	2014	Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine.	Arginine	71-81	nitric oxide synthase 3, endothelial cell	Mus musculus	23-38
20104527-3	2010	Tumoural downregulation of the enzyme argininosuccinate synthetase (ASS1), a recognised rate-limiting step in arginine synthesis, results in an intrinsic dependence on extracellular arginine due to an inability to synthesise arginine for growth.	Arginine	110-118	argininosuccinate synthase 1	Homo sapiens	68-72
20104527-3	2010	Tumoural downregulation of the enzyme argininosuccinate synthetase (ASS1), a recognised rate-limiting step in arginine synthesis, results in an intrinsic dependence on extracellular arginine due to an inability to synthesise arginine for growth.	Arginine	182-190	argininosuccinate synthase 1	Homo sapiens	68-72
20104527-3	2010	Tumoural downregulation of the enzyme argininosuccinate synthetase (ASS1), a recognised rate-limiting step in arginine synthesis, results in an intrinsic dependence on extracellular arginine due to an inability to synthesise arginine for growth.	Arginine	182-190	argininosuccinate synthase 1	Homo sapiens	68-72
20104527-5	2010	Several tumours are arginine auxotrophic, due to variable loss of ASS1, including hepatocellular carcinoma, malignant melanoma, malignant pleural mesothelioma, prostate and renal cancer.	Arginine	20-28	argininosuccinate synthase 1	Homo sapiens	66-70
20104527-7	2010	Several phase I/II clinical trials of the arginine-lowering drug, pegylated arginine deiminase, have shown encouraging evidence of clinical benefit and low toxicity in patients with ASS1-negative tumours.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	182-186
25320354-2	2014	Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine.	Arginine	71-81	nitric oxide synthase 3, endothelial cell	Mus musculus	40-44
20104527-8	2010	In part, ASS1 loss is due to epigenetic silencing of the ASS1 promoter in various human cancer cell lines and tumours, and it is this silencing that confers arginine auxotrophy.	Arginine	157-165	argininosuccinate synthase 1	Homo sapiens	9-13
20104527-11	2010	This review examines the prospects for novel approaches in the prevention, diagnosis and treatment of malignant disease based on ASS1 pathophysiology and its rate-limiting product, arginine.	Arginine	181-189	argininosuccinate synthase 1	Homo sapiens	129-133
25320354-3	2014	Lack of L-arginine results in reduced NO production and eNOS uncoupling, which lead to endothelial dysfunction.	Arginine	8-18	nitric oxide synthase 3, endothelial cell	Mus musculus	56-60
25253739-4	2014	Interestingly, bioactive mouse GDF9 and human BMP15 share the conserved arginine in the pre-helix loop, but their low-activity counterparts (mouse BMP15 and human GDF9) have a glycine or a proline instead.	Arginine	72-80	growth differentiation factor 9	Mus musculus	31-35
20201080-8	2010	PAD-4 was citrullinated at 10 sites, which are clustered into 3 distinct regions, including a cluster of arginines around the active site cleft where Arg-372 and -374 were identified as the potential autocitrullination targets that inactivate the enzyme.	Arginine	105-114	peptidyl arginine deiminase 4	Homo sapiens	0-5
20201080-8	2010	PAD-4 was citrullinated at 10 sites, which are clustered into 3 distinct regions, including a cluster of arginines around the active site cleft where Arg-372 and -374 were identified as the potential autocitrullination targets that inactivate the enzyme.	Arginine	150-153	peptidyl arginine deiminase 4	Homo sapiens	0-5
24385142-8	2014	The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively.	Arginine	140-143	argininosuccinate lyase	Rattus norvegicus	53-76
24385142-8	2014	The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively.	Arginine	140-143	argininosuccinate lyase	Rattus norvegicus	78-81
24385142-8	2014	The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively.	Arginine	140-143	argininosuccinate lyase	Rattus norvegicus	211-214
25407913-3	2014	Peptidyl-arginine deiminase 4 (PAD4) has been shown to convert arginine residues into the non-genetically encoded citrulline residue.	Arginine	9-17	peptidyl arginine deiminase 4	Homo sapiens	31-35
20188695-5	2010	This effect was abolished upon mutation of 4 arginines in p13"s alpha-helical domain that were previously shown to be essential for its activity in in vitro assays.	Arginine	45-54	H3 histone pseudogene 6	Homo sapiens	58-61
25375337-8	2014	It was found that the substitutions of Arg at positions 41 and 46 with Ala results in peptide analogues that reduce the severity of MOG-induced EAE clinical symptoms in C57BL/6 mice when co-administered with mouse MOG35-55 peptide at the time of immunization.	Arginine	39-42	myelin oligodendrocyte glycoprotein	Mus musculus	132-135
20479111-0	2010	State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation.	Arginine	49-58	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	80-85
20197281-4	2010	For one type of member AAA(+) protein (phage shock protein F, PspF), we identified and established the functional significance of strategically placed arginine and glutamate residues that form interacting pairs in response to nucleotide binding.	Arginine	151-159	coiled-coil domain containing 62	Homo sapiens	23-37
25347266-4	2014	PE, Pro, and Arg all lowered blood levels of lactic acid and alanine aminotransferase (ALT).	Arginine	13-16	glutamic pyruvic transaminase, soluble	Mus musculus	61-85
25347266-4	2014	PE, Pro, and Arg all lowered blood levels of lactic acid and alanine aminotransferase (ALT).	Arginine	13-16	glutamic pyruvic transaminase, soluble	Mus musculus	87-90
25172307-3	2014	We identified R526 methylation as the major post-translational modification of any NaV1.5 arginine or lysine residue.	Arginine	90-98	sodium voltage-gated channel alpha subunit 5	Homo sapiens	83-89
19694944-5	2010	In contrast, deletion of the juxtamembrane (Leu(150)-Arg(160)) or central (Ala(159)-Pro(170)) intracellular segment of GPIbbeta resulted in a 21% and 23% reduction in the number of cells extending filopodia, respectively.	Arginine	53-56	glycoprotein Ib, beta polypeptide	Mus musculus	119-127
25333616-5	2014	We found that leucine, tyrosine, arginine, homoarginine or glucose treatment of the GA1 model cells reduced the gene expression of caspase-3, caspase-8, caspase-9, bax, fos, and jun and restored the intracellular NADH and ATP levels.	Arginine	33-41	caspase 8	Mus musculus	142-151
25333616-5	2014	We found that leucine, tyrosine, arginine, homoarginine or glucose treatment of the GA1 model cells reduced the gene expression of caspase-3, caspase-8, caspase-9, bax, fos, and jun and restored the intracellular NADH and ATP levels.	Arginine	33-41	FBJ osteosarcoma oncogene	Mus musculus	169-172
20356038-10	2010	The same Arg in its neutral (pK(a) approximately 6.5) form also appears to act as the active-site base in binding reactions of protonated ligands, such as HCN, to ferric Cld.	Arginine	9-12	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	155-158
24166499-6	2014	Mutation of K76 into arginine (R) abolishes its sumoylation, disrupts merlin cortical cytoskeleton residency and attenuates its stability.	Arginine	21-29	keratin 76	Homo sapiens	12-15
20196153-0	2010	Poly(arginine)-selective coprecipitation properties of self-assembling apoferritin and Its Tb(3+) complex: a new luminescent biotool for sensing of poly(arginine) and its protein conjugates.	Arginine	5-13	ferritin heavy chain 1	Homo sapiens	71-82
25234600-8	2014	When the PEST sequence (Glu(31)-Cys(46)) was inserted into the L-type GATA-6 without Arg(13)-Gly(101), the resultant recombinant protein showed significantly higher transcriptional activity, while the construct with an unrelated sequence exhibited lower activity.	Arginine	85-88	GATA binding protein 6	Homo sapiens	70-76
20045558-2	2010	After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two distinct G protein-coupled receptors (GPCR), called B2 (B2R) or B1 (B1R).	Arginine	78-81	bradykinin receptor B2	Homo sapiens	159-161
20045558-2	2010	After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two distinct G protein-coupled receptors (GPCR), called B2 (B2R) or B1 (B1R).	Arginine	78-81	bradykinin receptor B2	Homo sapiens	163-166
24697328-1	2014	In cases of arginine depletion, lymphocyte proliferation, cytokine production and CD3zeta chain expression are all diminished.	Arginine	12-20	CD247 molecule	Homo sapiens	82-89
20077570-0	2010	NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.	Arginine	43-46	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	47-51
25195753-0	2014	Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.	Arginine	24-32	protein arginine N-methyltransferase 7	Mus musculus	58-94
20035742-1	2010	In mammalian brain, agmatine is an endogenous amine that is synthesized through the decarboxylation of l-arginine by arginine decarboxylase.	Arginine	103-113	antizyme inhibitor 2	Homo sapiens	117-139
25024404-5	2014	Structure-function analysis revealed that the arginine/serine-rich motif and the C-terminal zinc finger domain required for speckle localization are necessary for the adipocyte differentiation function of ZNF638 and for the regulation of the levels of alternatively spliced isoforms of lipin1 and nuclear receptor co-repressor 1.	Arginine	46-54	zinc finger protein 638	Homo sapiens	205-211
25156824-4	2014	Agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator and it protects neurons/glia against various injuries.	Arginine	49-59	antizyme inhibitor 2	Homo sapiens	63-85
20180533-6	2010	Finally, a second generation of cell permeable Pin1 inhibitors was designed by replacing the noncritical residues within the cyclic peptide ring with arginine residues and shown to have antiproliferative activity against the cancer cells.	Arginine	150-158	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	47-51
25156824-4	2014	Agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator and it protects neurons/glia against various injuries.	Arginine	49-59	antizyme inhibitor 2	Homo sapiens	87-90
20022955-4	2010	In a promoter-specific context, inhibition of H3R17 methylation represses expression of p21, a p53-responsive gene, thus implicating a possible role for H3 Arg-17 methylation in tumor suppressor function.	Arginine	156-159	H3 histone pseudogene 16	Homo sapiens	88-91
25111608-2	2014	The aim of this study was to evaluate whether L-Arginine (L-Arg) supplementation modifies nitric oxide (NO) system and consequently aquaporin-2 (AQP2) expression in the renal outer medulla of streptozotocin-diabetic rats at an early time point after induction of diabetes.	Arginine	46-56	aquaporin 2	Rattus norvegicus	132-143
20015989-2	2010	This hypothesis emphasized the importance of a balanced electrostatic interaction between the positive charge from the arginine-rich domain (ARD) of the core protein (HBc) and the negative charge from the encapsidated nucleic acid.	Arginine	119-127	keratin 88, pseudogene	Homo sapiens	167-170
25111608-2	2014	The aim of this study was to evaluate whether L-Arginine (L-Arg) supplementation modifies nitric oxide (NO) system and consequently aquaporin-2 (AQP2) expression in the renal outer medulla of streptozotocin-diabetic rats at an early time point after induction of diabetes.	Arginine	46-56	aquaporin 2	Rattus norvegicus	145-149
20015989-4	2010	HBc ARD IV mutant 173GG and ARD II mutant 173RR/R157A/R158A are arginine deficient and replication defective.	Arginine	64-72	keratin 88, pseudogene	Homo sapiens	0-3
25111608-2	2014	The aim of this study was to evaluate whether L-Arginine (L-Arg) supplementation modifies nitric oxide (NO) system and consequently aquaporin-2 (AQP2) expression in the renal outer medulla of streptozotocin-diabetic rats at an early time point after induction of diabetes.	Arginine	46-51	aquaporin 2	Rattus norvegicus	132-143
25111608-2	2014	The aim of this study was to evaluate whether L-Arginine (L-Arg) supplementation modifies nitric oxide (NO) system and consequently aquaporin-2 (AQP2) expression in the renal outer medulla of streptozotocin-diabetic rats at an early time point after induction of diabetes.	Arginine	46-51	aquaporin 2	Rattus norvegicus	145-149
20159990-6	2010	ASS is one of the enzymes required for the production of a nonessential amino acid, arginine.	Arginine	84-92	argininosuccinate synthase 1	Homo sapiens	0-3
20159990-7	2010	We showed that osteosarcoma cells lacking ASS expression were auxotrophic for arginine and underwent G(0)-G(1) arrest in arginine-free medium, suggesting that an arginine deprivation therapy could be effective in patients with osteosarcoma.	Arginine	78-86	argininosuccinate synthase 1	Homo sapiens	42-45
25084831-4	2014	This study aimed to determine whether neutrophils that co-purify with PBMC express arginase, and if arginine depletion constrains T cell CD3 zeta-chain expression and function in human sepsis.	Arginine	100-108	CD247 molecule	Homo sapiens	137-151
24907272-6	2014	Furthermore, we proved that arginines 73 and 74 within the ARM of RNF4 are required for efficient recruitment to KAP1 or accelerated degradation of promyelocytic leukemia protein (PML) under stress.	Arginine	28-37	ring finger protein 4	Homo sapiens	66-70
20159990-7	2010	We showed that osteosarcoma cells lacking ASS expression were auxotrophic for arginine and underwent G(0)-G(1) arrest in arginine-free medium, suggesting that an arginine deprivation therapy could be effective in patients with osteosarcoma.	Arginine	121-129	argininosuccinate synthase 1	Homo sapiens	42-45
20159990-7	2010	We showed that osteosarcoma cells lacking ASS expression were auxotrophic for arginine and underwent G(0)-G(1) arrest in arginine-free medium, suggesting that an arginine deprivation therapy could be effective in patients with osteosarcoma.	Arginine	121-129	argininosuccinate synthase 1	Homo sapiens	42-45
24907272-6	2014	Furthermore, we proved that arginines 73 and 74 within the ARM of RNF4 are required for efficient recruitment to KAP1 or accelerated degradation of promyelocytic leukemia protein (PML) under stress.	Arginine	28-37	PML nuclear body scaffold	Homo sapiens	148-178
24907272-6	2014	Furthermore, we proved that arginines 73 and 74 within the ARM of RNF4 are required for efficient recruitment to KAP1 or accelerated degradation of promyelocytic leukemia protein (PML) under stress.	Arginine	28-37	PML nuclear body scaffold	Homo sapiens	180-183
20025242-3	2010	These reductases contain an active site C-X(5)-R signature motif, where C is the catalytic cysteine, the five X residues form a phosphate binding loop, and R is a highly conserved arginine, which is also present in human Cdc25 phosphatases.	Arginine	180-188	cell division cycle 25C	Homo sapiens	221-226
24937104-0	2014	GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.	Arginine	140-143	pyroglutamylated RFamide peptide receptor	Rattus norvegicus	0-6
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Arginine	212-215	complement C2	Homo sapiens	137-140
24802387-5	2014	Mutagenesis of the conserved positively charged Arg residues of relaxin-3 demonstrated that B12Arg, B16Arg and B26Arg were all involved in the binding and activation of RXFP4, especially B26Arg.	Arginine	48-51	relaxin 3	Homo sapiens	64-73
20067468-11	2010	CONCLUSIONS AND IMPLICATIONS: Exogenous l-arginine increased NO formation via raised levels of eNOS induced by resveratrol and protected against the pro-ulcer effects of resveratrol.	Arginine	40-50	nitric oxide synthase 3, endothelial cell	Mus musculus	95-99
24692659-3	2014	We report that in addition to the C-terminal region of hnRNP G, the RNA Recognition Motif (RRM) and the middle part of the protein containing the Arg-Gly-Gly (RGG) box are important for this function.	Arginine	146-149	RBMX pseudogene 1	Homo sapiens	55-62
20043879-0	2010	Probing the roles of conserved arginine-44 of Escherichia coli dihydrofolate reductase in its function and stability by systematic sequence perturbation analysis.	Arginine	31-39	Dihydrofolate reductase	Escherichia coli	63-86
24726727-1	2014	Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues.	Arginine	8-16	Protein arginine N-methyltransferase 7	Caenorhabditis elegans	38-43
20090832-8	2010	An arginine residue at this position however, as found for example in MICA or ULBP3, would cause steric clashes with UL16 residues.	Arginine	3-11	UL16 binding protein 3	Homo sapiens	78-83
24692540-8	2014	The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6.	Arginine	58-61	FA complementation group B	Homo sapiens	130-133
20039406-2	2010	Peptidyl arginine deiminase type 4 (PAD-4), the enzyme that converts arginine into citrulline, is in itself a target for RA-specific autoantibodies.	Arginine	9-17	peptidyl arginine deiminase 4	Homo sapiens	36-41
24692540-8	2014	The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6.	Arginine	76-79	FA complementation group B	Homo sapiens	130-133
24692540-8	2014	The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6.	Arginine	76-79	FA complementation group B	Homo sapiens	130-133
24755078-6	2014	We performed site-directed mutagenesis of the MdmX RING domain and found that the substitution of the residue N448 for cysteine and the substitution of the residue K478 for arginine granted MdmX RING domain ubiquitination activity.	Arginine	173-181	MDM4 regulator of p53	Homo sapiens	46-50
20831043-7	2010	For polymorphic marker Trp64Arg of ADRB3 gene frequency of Trp allele turned out to be significantly higher (OR 2.20, p = 0.0176), while frequency of Arg allele significantly lower (OR 0.43, p = 0.0176) in the group of patients with AF.	Arginine	28-31	adrenoceptor beta 3	Homo sapiens	35-40
24755078-6	2014	We performed site-directed mutagenesis of the MdmX RING domain and found that the substitution of the residue N448 for cysteine and the substitution of the residue K478 for arginine granted MdmX RING domain ubiquitination activity.	Arginine	173-181	MDM4 regulator of p53	Homo sapiens	190-194
19858291-3	2010	We show that Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo.	Arginine	112-120	chromatin target of PRMT1	Homo sapiens	13-16
24884799-1	2014	BACKGROUND: Argininosuccinate synthetase (ASS) participates in urea, nitric oxide and arginine production.	Arginine	86-94	argininosuccinate synthetase 1	Mus musculus	12-40
20117988-4	2010	The apoptosis of L-Arg-treated cells was observed by the Annexin V/PI staining.	Arginine	17-22	annexin A5	Homo sapiens	57-66
24884799-1	2014	BACKGROUND: Argininosuccinate synthetase (ASS) participates in urea, nitric oxide and arginine production.	Arginine	86-94	argininosuccinate synthetase 1	Mus musculus	42-45
24556046-10	2014	Interestingly, L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis.	Arginine	15-20	argininosuccinate synthetase 1	Mus musculus	58-62
22966251-2	2010	Arginine, the product of ASS, has been used as a target in HCC by recombinant human arginase or arginine deiminase, which is now in the phase II clinical trial stage.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	25-28
24556046-10	2014	Interestingly, L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis.	Arginine	115-120	argininosuccinate synthetase 1	Mus musculus	58-62
24556046-11	2014	These findings highlight that cAMP-induced Ass1 expression is important in controlling the magnitude of decidualization through regulating L-Arg level.	Arginine	139-144	argininosuccinate synthetase 1	Mus musculus	43-47
24860943-0	2014	Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling.	Arginine	22-32	ribosomal protein S6 kinase B1	Homo sapiens	97-101
20129366-8	2009	RESULTS: DGGE screening of the LDLR gene identified a tryptophan (W) to arginine (R) substitution at residue 556 (p.W556R) in the fifth conserved YWTD repeat of the LDLR-beta-propeller in FH(Marburg).	Arginine	72-80	low density lipoprotein receptor	Homo sapiens	31-35
20129366-8	2009	RESULTS: DGGE screening of the LDLR gene identified a tryptophan (W) to arginine (R) substitution at residue 556 (p.W556R) in the fifth conserved YWTD repeat of the LDLR-beta-propeller in FH(Marburg).	Arginine	72-80	low density lipoprotein receptor	Homo sapiens	165-169
24860943-6	2014	While acute L-arginine treatment enhances endothelial NO production accompanied with superoxide production and activation of S6K1 but no up-regulation of arginase-II, chronic L-arginine supplementation causes endothelial senescence, up-regulation of the adhesion molecule expression, and eNOS-uncoupling (decreased NO and enhanced superoxide production), which are associated with S6K1 activation and up-regulation of arginase-II.	Arginine	12-22	ribosomal protein S6 kinase B1	Homo sapiens	125-129
24860943-6	2014	While acute L-arginine treatment enhances endothelial NO production accompanied with superoxide production and activation of S6K1 but no up-regulation of arginase-II, chronic L-arginine supplementation causes endothelial senescence, up-regulation of the adhesion molecule expression, and eNOS-uncoupling (decreased NO and enhanced superoxide production), which are associated with S6K1 activation and up-regulation of arginase-II.	Arginine	12-22	ribosomal protein S6 kinase B1	Homo sapiens	381-385
19875446-7	2009	Site-directed mutagenesis of GLYT2 EL4 residues was used to identify the key residues Arg(531), Lys(532), and Ile(545) that contribute to the differences in NAGly sensitivity.	Arginine	86-89	solute carrier family 6 member 5	Rattus norvegicus	29-34
24860943-6	2014	While acute L-arginine treatment enhances endothelial NO production accompanied with superoxide production and activation of S6K1 but no up-regulation of arginase-II, chronic L-arginine supplementation causes endothelial senescence, up-regulation of the adhesion molecule expression, and eNOS-uncoupling (decreased NO and enhanced superoxide production), which are associated with S6K1 activation and up-regulation of arginase-II.	Arginine	175-185	ribosomal protein S6 kinase B1	Homo sapiens	381-385
24860943-7	2014	Silencing either S6K1 or arginase-II inhibits up-regulation/activation of each other, prevents endothelial dysfunction, adhesion molecule expression, and senescence under the chronic L-arginine supplementation condition.	Arginine	183-193	ribosomal protein S6 kinase B1	Homo sapiens	17-21
24860943-8	2014	These results demonstrate that S6K1 and arginase-II form a positive circuit mediating the detrimental effects of chronic L-arginine supplementation on endothelial cells.	Arginine	121-131	ribosomal protein S6 kinase B1	Homo sapiens	31-35
24330949-9	2014	Collectively, Arg supplementation attenuated the overexpression of pro-inflammatory cytokines probably through the suppression of the TLR4 pathway and CD14+ cell percentage.	Arginine	14-17	CD14 molecule	Gallus gallus	151-155
19934275-6	2009	Under arginine depletion conditions, HIF-1alpha was replaced by c-Myc in A2058 and SK-MEL-2 cells but not in A375 cells.	Arginine	6-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
24428817-11	2014	CONCLUSION: Augmented endothelial l-arginine transport attenuated the prohypertensive effects of systemic and renal oxidative stress, suggesting that manipulation of endothelial CAT1 may provide a new therapeutic approach for the treatment of cardiovascular disease associated with oxidative stress.	Arginine	34-44	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	178-182
19759001-7	2009	A 2.5 A crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175.	Arginine	78-81	formin 1	Homo sapiens	93-96
24622112-6	2014	The association between percentage DNA methylation in ARG and NOS genes with CIMT was evaluated using linear regression adjusted for sex, ethnicity, body mass index, age at CIMT, town of residence, and experimental plate for pyrosequencing reactions.	Arginine	54-57	CIMT	Homo sapiens	77-81
19759001-7	2009	A 2.5 A crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175.	Arginine	78-81	formin 1	Homo sapiens	185-188
19759001-7	2009	A 2.5 A crystal structure of the R229W variant shows that the substitution of Arg-229 at the FMN binding site has led to a loss of hydrogen-bond and/or salt-bridge interactions between FMN and Arg-229 and Ser-175.	Arginine	193-196	formin 1	Homo sapiens	93-96
24692592-3	2014	Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid tumors, making them sensitive to external arginine depletion.	Arginine	57-65	argininosuccinate synthase 1	Homo sapiens	0-30
19818773-2	2009	The currently-accepted mechanism involves removal of a constraint on the antithrombin reactive center loop (RCL) so that the proteinase can simultaneously engage both the P1 arginine and an exosite at Y253.	Arginine	174-182	serpin family C member 1	Homo sapiens	73-85
24692592-3	2014	Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid tumors, making them sensitive to external arginine depletion.	Arginine	57-65	argininosuccinate synthase 1	Homo sapiens	32-36
24692592-3	2014	Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid tumors, making them sensitive to external arginine depletion.	Arginine	165-173	argininosuccinate synthase 1	Homo sapiens	0-30
24692592-3	2014	Argininosuccinate synthetase 1 (ASS1) is a key enzyme in arginine biosynthesis, and its abundance is reduced in many solid tumors, making them sensitive to external arginine depletion.	Arginine	165-173	argininosuccinate synthase 1	Homo sapiens	32-36
19878914-9	2009	An electrophoretic mobility-shift assay showed that essential splicing factors, serine/arginine-rich splicing factors SFRS1 and SFRS9, bind to (UGGAA)n in vitro.	Arginine	87-95	serine and arginine rich splicing factor 9	Homo sapiens	128-133
24692592-9	2014	Last, ASS1 was either low in abundance or absent in more than 60% of 149 random breast cancer biosamples, suggesting that patients with such tumors could be candidates for arginine starvation therapy.	Arginine	172-180	argininosuccinate synthase 1	Homo sapiens	6-10
24308431-0	2014	Application of SILAC labeling to primary bone marrow-derived dendritic cells reveals extensive GM-CSF-dependent arginine metabolism.	Arginine	112-120	colony stimulating factor 2	Homo sapiens	95-101
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	143-146	adenosine A2a receptor	Homo sapiens	183-192
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	147-150	adenosine A2a receptor	Homo sapiens	183-192
19905915-8	2009	We found a significant association between favorable therapeutic response to inhaled beta(2)-adrenergic agonists in asthmatic children and the Arg/Arg phenotype at position 16 of the beta(2)AR [OR = 1.77; 95% CI (1.01; 3.1); p = 0.029], compared with the Arg/Gly or Gly/Gly phenotypes.	Arginine	147-150	adenosine A2a receptor	Homo sapiens	183-192
19905915-9	2009	The beneficial effect of Arg at position 16 of the beta(2)AR was most pronounced in African-American asthmatic children [OR = 3.54; 95% CI (1.37, 9.13)].	Arginine	25-28	adenosine A2a receptor	Homo sapiens	51-60
20067119-8	2009	The apoA I and apoA II levels decreased in the obese and non-obese males with Arg/Arg (P &lt; 0.05).	Arginine	78-81	apolipoprotein A2	Homo sapiens	15-22
24507716-4	2014	TDRD3 serves as a molecular bridge between TOP3B and arginine-methylated histones.	Arginine	53-61	tudor domain containing 3	Mus musculus	0-5
20067119-8	2009	The apoA I and apoA II levels decreased in the obese and non-obese males with Arg/Arg (P &lt; 0.05).	Arginine	82-85	apolipoprotein A2	Homo sapiens	15-22
24504800-10	2014	These were better able to bind to HLA-B27 than were N-terminally extended peptides lacking an arginine at position 2.	Arginine	94-102	major histocompatibility complex, class I, B	Homo sapiens	34-41
20034235-7	2009	The increased XO, MPO, and MDA levels of these tissues significantly decreased in exercised rats supplemented with L-Arg.	Arginine	115-120	myeloperoxidase	Rattus norvegicus	18-21
24285724-12	2014	Taken together, our findings argue that arginine deprivation combined with antifolates warrants clinical investigation in ASS1-negative urothelial and related cancers, using FLT-PET as an early surrogate marker of response.	Arginine	40-48	argininosuccinate synthase 1	Homo sapiens	122-126
19791743-5	2009	Modeling of the binding mode of 67 suggests that the cyanoguanidine moiety forms charge-assisted hydrogen bonds not only with the conserved Asp-94 but also with the hH4R-specific Arg-341 residue.	Arginine	179-182	histamine receptor H4	Homo sapiens	165-169
24382305-8	2014	Human NEIL1 is known to undergo editing whereby the lysine at position 242 is recoded into an arginine.	Arginine	94-102	nei like DNA glycosylase 1	Homo sapiens	6-11
18821052-9	2009	In addition, Arg elevated the levels of serum interleukin-2 and interferon-gamma (P &lt; 0.05) on day 28, and mitigated the decrease of serum interferon-gamma level on day 21 (P &lt; 0.05).	Arginine	13-16	interleukin 2	Sus scrofa	46-59
24324264-6	2014	Surprisingly, young Arg-61 mice had more mitotic doublecortin-positive cells in the subgranular zone; mRNA levels of brain-derived neurotrophic factor (BDNF) and TrkB were also higher in 3-month-old Arg-61 hippocampus compared with C57BL/6J mice.	Arginine	20-23	doublecortin	Mus musculus	49-61
19589617-1	2009	We have studied myoblasts from a patient with a severe autosomal dominant Emery-Dreifuss muscular dystrophy (AD-EDMD) caused by an arginine 545 to cystein point mutation (p.R545C) in the carboxy-terminal domain of the lamin A/C gene.	Arginine	131-139	lamin A/C	Homo sapiens	218-227
24324264-6	2014	Surprisingly, young Arg-61 mice had more mitotic doublecortin-positive cells in the subgranular zone; mRNA levels of brain-derived neurotrophic factor (BDNF) and TrkB were also higher in 3-month-old Arg-61 hippocampus compared with C57BL/6J mice.	Arginine	20-23	brain derived neurotrophic factor	Mus musculus	117-150
20641832-9	2004	(6) has identified a modified peptide, (N(alpha)His)Ac-(Arg-N-CH3)-Arg-Pro-(dimethyl-Tyr)-(tertary-Leu)-Leu (NT-XIX), to be metabolically stable in plasma with good affinity for NTR1.	Arginine	55-59	neurotensin receptor 1	Mus musculus	178-182
24324264-6	2014	Surprisingly, young Arg-61 mice had more mitotic doublecortin-positive cells in the subgranular zone; mRNA levels of brain-derived neurotrophic factor (BDNF) and TrkB were also higher in 3-month-old Arg-61 hippocampus compared with C57BL/6J mice.	Arginine	20-23	brain derived neurotrophic factor	Mus musculus	152-156
20641832-9	2004	(6) has identified a modified peptide, (N(alpha)His)Ac-(Arg-N-CH3)-Arg-Pro-(dimethyl-Tyr)-(tertary-Leu)-Leu (NT-XIX), to be metabolically stable in plasma with good affinity for NTR1.	Arginine	56-59	neurotensin receptor 1	Mus musculus	178-182
24324264-8	2014	This is supported by the higher cleaved caspase-3 levels in the young animals that not only persisted, but increased in old age, and the lower levels of doublecortin at old age in the hippocampus of Arg-61 mice.	Arginine	199-202	doublecortin	Mus musculus	153-165
24453340-7	2014	Domain deletion analysis indicated that the N-terminal domain of Bclaf1 containing an arginine-serine-rich and a bZip domain is required for its effects on retinal cell differentiation.	Arginine	86-94	BCL2-associated transcription factor 1	Mus musculus	65-71
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Arginine	107-115	estrogen receptor 1 (alpha)	Mus musculus	36-59
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Arginine	107-115	estrogen receptor 1 (alpha)	Mus musculus	61-68
19561644-1	2009	We identified a somatic mutation in estrogen receptor-alpha (ERalpha) in breast cancer causing a lysine to arginine transition (K303R) resulting in hypersensitivity to estrogen, altered associations with coactivators and corepressors and altered posttranslational modifications of ERalpha.	Arginine	107-115	estrogen receptor 1 (alpha)	Mus musculus	281-288
24419624-2	2014	PRMT7 is the only known PRMT member that catalyzes the monomethylation but not the dimethylation of the target arginine residues and harbours two catalytic domains in tandem.	Arginine	111-119	protein arginine N-methyltransferase 7	Mus musculus	0-5
24727379-7	2014	The structure establishes that the Tat-TAR recognition motif (TRM) in Cyclin T1 interacts with both Tat and AFF4, leading to the exposure of arginine side chains for binding to TAR RNA.	Arginine	141-149	AF4/FMR2 family member 4	Homo sapiens	108-112
19452503-11	2009	Therefore, MC1R export is likely regulated by T157 phosphorylation and the (160)RARR(163) arginine-based motif functions as an ER retrieval signal.	Arginine	90-98	melanocortin 1 receptor	Homo sapiens	11-15
24714829-9	2014	Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline.	Arginine	78-86	leptin	Homo sapiens	7-13
19706734-2	2009	The Ser(88)-Arg-Ser-Arg-Tyr(92) is the minimum chemotactic sequence of uPAR required to induce the same intracellular signaling as its ligand uPA.	Arginine	12-15	plasminogen activator, urokinase receptor	Homo sapiens	71-75
19653641-9	2009	We also estimated galanin receptor-mediated endocytosis of QD-AST1 at &lt;10% by blocking the cells with a galanin antagonist and transduction at &lt;30% by both removing the charge of the peptide due to arginine and suppressing the cell-surface charge due to glycosaminoglycan.	Arginine	204-212	glutamic-oxaloacetic transaminase 1	Homo sapiens	62-66
24232602-8	2014	In A1-A5 and A8, position 514 amino acid (514 aa) of MX2 was glycine (Gly), which did not inhibit VSV multiplication, whereas in A6 and A7, 514 aa was arginine (Arg), which exhibited the antiviral ability against VSV.	Arginine	151-159	interferon-induced GTP-binding protein Mx2	Sus scrofa	53-56
24232602-8	2014	In A1-A5 and A8, position 514 amino acid (514 aa) of MX2 was glycine (Gly), which did not inhibit VSV multiplication, whereas in A6 and A7, 514 aa was arginine (Arg), which exhibited the antiviral ability against VSV.	Arginine	161-164	interferon-induced GTP-binding protein Mx2	Sus scrofa	53-56
25348593-6	2014	RESULTS: The 2 affected family members harbored a novel missense mutation, G1618A, in the SLC20A2 gene, leading to gly540-to-arg (G540R) substitution in a highly conserved residue.	Arginine	125-128	solute carrier family 20 member 2	Homo sapiens	90-97
19652352-3	2009	Mss116p exhibited low solubility in standard solutions (&lt; or =1 mg ml(-1)), but its solubility could be increased by adding 50 mM L-arginine plus 50 mM L-glutamate and 50% glycerol to achieve concentrations of approximately 10 mg ml(-1).	Arginine	133-143	ATP-dependent RNA helicase	Saccharomyces cerevisiae S288C	0-7
24000822-5	2014	The inhibitor was stabilized by hydrogen bonding interactions with residues Arg 145, Asn 566, Pro 731 and His 732 of hECE-1.	Arginine	76-79	endothelin converting enzyme 1	Homo sapiens	117-123
19384818-6	2009	Additionally, the modification of arginine leading to argpyrimidine and the phosphorylation of Hsp27 are increased in the myocardium of patients with DM.	Arginine	34-42	heat shock protein family B (small) member 1	Homo sapiens	95-100
19491403-0	2009	Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production.	Arginine	105-113	argininosuccinate synthase 1	Homo sapiens	0-28
24055001-4	2013	Gly161 is a highly conserved residue whose mutation to Arg, Cys or Ser is associated with PH1.	Arginine	55-58	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	90-93
19491403-7	2009	Accordingly, the functional interaction of Bj-BPP-10c and AsS was evidenced by the following effects promoted by the peptide: (i) increase of NO metabolite production in human umbilical vein endothelial cell culture and of arginine in human embryonic kidney cells and (ii) increase of arginine plasma concentration in SHR.	Arginine	223-231	argininosuccinate synthase 1	Homo sapiens	58-61
19491403-7	2009	Accordingly, the functional interaction of Bj-BPP-10c and AsS was evidenced by the following effects promoted by the peptide: (i) increase of NO metabolite production in human umbilical vein endothelial cell culture and of arginine in human embryonic kidney cells and (ii) increase of arginine plasma concentration in SHR.	Arginine	285-293	argininosuccinate synthase 1	Homo sapiens	58-61
24839613-3	2013	Arginine-grafted poly (cystaminebisacrylamide-diaminohexane) (ABP)-conjugated poly (amido amine) (PAMAM) dendrimer (PAM-ABP) was used as gene carrier.	Arginine	0-8	amine oxidase, copper-containing 1	Mus musculus	62-65
19508952-9	2009	A ST3Gal-I mutant protein which was converted (335)Arg residue in the C-terminal region to Glu, was rather insensitive to the PM, suggesting that specific C-terminal basic amino acid of ST3Gal-I is involved in the binding to PMs.	Arginine	51-54	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	2-10
19508952-9	2009	A ST3Gal-I mutant protein which was converted (335)Arg residue in the C-terminal region to Glu, was rather insensitive to the PM, suggesting that specific C-terminal basic amino acid of ST3Gal-I is involved in the binding to PMs.	Arginine	51-54	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	186-194
19465398-4	2009	Here, we demonstrate that HMGA1a/b and HMGA2 possess intrinsic dRP and AP site cleavage activities, and that lysines and arginines in the AT-hook DNA-binding domains function as nucleophiles.	Arginine	121-130	high mobility group AT-hook 1	Homo sapiens	26-32
19465398-4	2009	Here, we demonstrate that HMGA1a/b and HMGA2 possess intrinsic dRP and AP site cleavage activities, and that lysines and arginines in the AT-hook DNA-binding domains function as nucleophiles.	Arginine	121-130	high mobility group AT-hook 2	Homo sapiens	39-44
19233287-3	2009	In this work, a comparative study was carried out on refolding of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in the presence of different concentrations of urea, guanidinium chloride or arginine.	Arginine	209-217	colony stimulating factor 3	Homo sapiens	84-121
19174306-3	2009	METHODS: Interference with ENTPDase activity in platelets of hypertensive patients and healthy donors was evaluated for arginine, sodium nitroprusside, and hydralazine.	Arginine	120-128	ectonucleoside triphosphate diphosphohydrolase 8	Homo sapiens	27-35
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	29-32	neural cell adhesion molecule 1	Homo sapiens	123-127
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	38-41	neural cell adhesion molecule 1	Homo sapiens	123-127
19336400-11	2009	We found that replacement of Arg(276)/Arg(277) or Arg(265) in the polysialyltransferase domain of ST8Sia IV decreased both NCAM polysialylation and autopolysialylation in parallel, suggesting that these residues are important for catalytic activity.	Arginine	38-41	neural cell adhesion molecule 1	Homo sapiens	123-127
19336400-12	2009	In contrast, replacing Arg(82)/Arg(93) in ST8Sia IV with alanine substantially decreased NCAM-specific polysialylation while only partially impacting autopolysialylation, suggesting that these residues may be particularly important for NCAM polysialylation.	Arginine	23-26	neural cell adhesion molecule 1	Homo sapiens	89-93
19336400-12	2009	In contrast, replacing Arg(82)/Arg(93) in ST8Sia IV with alanine substantially decreased NCAM-specific polysialylation while only partially impacting autopolysialylation, suggesting that these residues may be particularly important for NCAM polysialylation.	Arginine	23-26	neural cell adhesion molecule 1	Homo sapiens	236-240
19350350-4	2009	In this study, CBF values obtained by the autoradiographic (ARG) method obtained from both IMP(A) and IMP(B) were compared in the same human subjects.	Arginine	60-63	inositol monophosphatase 1	Homo sapiens	91-97
19350350-6	2009	Standard input functions used in the ARG method were obtained for both IMP(A) and IMP(B) from 5 additional healthy subjects.	Arginine	37-40	inositol monophosphatase 1	Homo sapiens	71-77
24839613-3	2013	Arginine-grafted poly (cystaminebisacrylamide-diaminohexane) (ABP)-conjugated poly (amido amine) (PAMAM) dendrimer (PAM-ABP) was used as gene carrier.	Arginine	0-8	amine oxidase, copper-containing 1	Mus musculus	120-123
24126913-5	2013	The arch contains basic residues (Lys-93 and Arg-100 in human FEN1 (hFEN1)) that are conserved by all 5"-nucleases and a cap region only present in enzymes that process DNAs with 5" termini.	Arginine	45-48	flap structure-specific endonuclease 1	Homo sapiens	62-66
24126913-5	2013	The arch contains basic residues (Lys-93 and Arg-100 in human FEN1 (hFEN1)) that are conserved by all 5"-nucleases and a cap region only present in enzymes that process DNAs with 5" termini.	Arginine	45-48	flap structure-specific endonuclease 1	Homo sapiens	68-73
24088021-4	2013	We identified eight cathepsin K specific arginine/lysine residues that form three positively charged clusters at the bottom part of the protease opposing the active site.	Arginine	41-49	cathepsin K	Homo sapiens	20-31
23916785-2	2013	Arg is activated downstream of integrin alpha3beta1 receptors and it regulates the neuronal actin cytoskeleton by directly binding F-actin and via phosphorylation of substrates including p190RhoGAP and cortactin.	Arginine	0-3	cortactin	Mus musculus	202-211
24095712-3	2013	In the presence of 100-200 mM NaCl, 50 mM arginine was more effective than other additives tested, including NaCl, in myosin solubilization.	Arginine	42-50	myosin heavy chain 14	Homo sapiens	118-124
24095712-6	2013	No structural changes in myosin caused by arginine were observed, which indicated that arginine enhanced the solubility of myosin in a physiological salt solution without affecting the structure.	Arginine	87-95	myosin heavy chain 14	Homo sapiens	123-129
24052262-5	2013	Combining an in-depth flow cytometry analysis with mutagenesis of lysine residues within CH1, we find that arginine substitution at each of a cluster of three lysines (Lys-42, Lys-43, and Lys-135) renders FLNa resistant to ASB2alpha-mediated degradation without altering ASB2alpha binding.	Arginine	107-115	SUN domain containing ossification factor	Homo sapiens	89-92
19459978-3	2009	Ipk2p/Arg82p is also a component of ArgR-Mcm1p complex that regulates transcription of genes involved in arginine metabolism.	Arginine	105-113	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-5
19459978-3	2009	Ipk2p/Arg82p is also a component of ArgR-Mcm1p complex that regulates transcription of genes involved in arginine metabolism.	Arginine	105-113	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	6-12
19459978-3	2009	Ipk2p/Arg82p is also a component of ArgR-Mcm1p complex that regulates transcription of genes involved in arginine metabolism.	Arginine	105-113	transcription factor MCM1	Saccharomyces cerevisiae S288C	41-46
24396821-7	2013	An hMLH2 gene mutation was detected at codon 629 codon of exon 12, in which a glutamine was replaced with an arginine (1886A&gt;G [p.Gln629Arg]).	Arginine	109-117	PMS1 homolog 1, mismatch repair system component	Homo sapiens	3-8
19238562-5	2009	The mapping of deletion mutants of atSR45a proteins revealed that the C-terminal arginine/serine-rich (RS) domain of atSR45a proteins are required for the interaction with U1-70K, U2AF(35)b, atSR45, atSCL28, PRP38-like protein, and themselves, and the N-terminal RS domain enhances the interaction efficiency.	Arginine	81-89	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	35-42
19238562-5	2009	The mapping of deletion mutants of atSR45a proteins revealed that the C-terminal arginine/serine-rich (RS) domain of atSR45a proteins are required for the interaction with U1-70K, U2AF(35)b, atSR45, atSCL28, PRP38-like protein, and themselves, and the N-terminal RS domain enhances the interaction efficiency.	Arginine	81-89	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	117-124
19138817-3	2009	The data support the roles previously proposed for ornithine transcarbamylase (OTC) in the arginine auxotrophy and rhArg-PEG sensitivity of HCC cells.	Arginine	91-99	ornithine transcarbamylase	Homo sapiens	51-77
24048198-11	2013	CONCLUSIONS: Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension.	Arginine	73-83	nitric oxide synthase 3, endothelial cell	Mus musculus	88-121
19138817-3	2009	The data support the roles previously proposed for ornithine transcarbamylase (OTC) in the arginine auxotrophy and rhArg-PEG sensitivity of HCC cells.	Arginine	91-99	ornithine transcarbamylase	Homo sapiens	79-82
19414610-2	2009	In this study, we show that interactions between Arg and the Arp2/3 complex regulator cortactin are essential to mediate actin-based cell edge protrusion during fibroblast adhesion to fibronectin.	Arginine	49-52	actin related protein 2	Homo sapiens	61-65
19414610-8	2009	These results demonstrate that interactions between Arg, cortactin, and Nck1 are critical to promote adhesion-dependent cell edge protrusions.	Arginine	52-55	NCK adaptor protein 1	Homo sapiens	72-76
19326097-3	2009	Bioinformatic analysis revealed that VVA0331 consist of nineteen 87-amino acid repeats, two Arg-Gly-Asp motifs, four cysteine residues, an outer membrane protein domain, a polysaccharide-binding site and several motifs related to cell adhesions.	Arginine	92-95	BJE04_RS17365	Vibrio vulnificus YJ016	37-44
24124444-5	2013	CPA1 and CPA2 encode a carbamoyl phosphate synthase involved in arginine biosynthesis and HMS1 a helix-loop-helix transcription factor.	Arginine	64-72	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	0-4
19116344-2	2009	Phosphorylation of the arginine/serine dipeptide-rich (RS) domain by SR protein kinases such as Cdc2-like kinases (Clk/Sty) modulates their subcellular localization and activation.	Arginine	23-31	small thymus	Mus musculus	115-122
19204007-7	2009	Using mass spectrometry, we found that the cp-2 fragment is generated by cleavage of huntingtin at position Arg(167).	Arginine	108-111	ceruloplasmin	Homo sapiens	43-47
24124444-5	2013	CPA1 and CPA2 encode a carbamoyl phosphate synthase involved in arginine biosynthesis and HMS1 a helix-loop-helix transcription factor.	Arginine	64-72	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2	Saccharomyces cerevisiae S288C	9-13
19284480-0	2009	Altered arginine metabolism in the central nervous system (CNS) of the Cln3-/- mouse model of juvenile Batten disease.	Arginine	8-16	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	71-75
19284480-2	2009	AIM: Recent evidence suggests that a disruption in CLN3 function results in altered regulation of arginine transport into lysosomes, and may influence intracellular arginine levels.	Arginine	98-106	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	51-55
23912080-2	2013	We have recently reported that NaV1.5 is post-translationally modified by arginine methylation.	Arginine	74-82	sodium voltage-gated channel alpha subunit 5	Homo sapiens	31-37
19284480-2	2009	AIM: Recent evidence suggests that a disruption in CLN3 function results in altered regulation of arginine transport into lysosomes, and may influence intracellular arginine levels.	Arginine	165-173	ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)	Mus musculus	51-55
23912080-3	2013	Here, we aimed to identify the enzymes that methylate NaV1.5, and to describe the role of arginine methylation on NaV1.5 function.	Arginine	90-98	sodium voltage-gated channel alpha subunit 5	Homo sapiens	114-120
24204302-2	2013	Linkage analysis and whole exome sequencing were used to identify the causal nonsense mutation, which changed an arginine codon into a stop at position 127 of the tRNA methyltransferase homolog gene TRMT10A (also called RG9MTD2).	Arginine	113-121	tRNA methyltransferase 10A	Homo sapiens	199-206
19328069-5	2009	Lethality caused by mutating both residues to arginine is suppressed by the scc3, pds5, and rad61 mutants.	Arginine	46-54	Rad61p	Saccharomyces cerevisiae S288C	92-97
24204302-2	2013	Linkage analysis and whole exome sequencing were used to identify the causal nonsense mutation, which changed an arginine codon into a stop at position 127 of the tRNA methyltransferase homolog gene TRMT10A (also called RG9MTD2).	Arginine	113-121	tRNA methyltransferase 10A	Homo sapiens	220-227
24098712-5	2013	It has been suggested that arginine methylation regulates the nucleocytoplasmic distribution of hnRNP A/B proteins.	Arginine	27-35	heterogeneous nuclear ribonucleoprotein A/B	Homo sapiens	96-105
19217439-2	2009	Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	84-92	argininosuccinate synthase 1	Homo sapiens	136-164
19217439-2	2009	Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	84-92	argininosuccinate synthase 1	Homo sapiens	166-169
24025624-0	2013	Arginine rich short linear motif of HIV-1 regulatory proteins inhibits dicer dependent RNA interference.	Arginine	0-8	dicer 1, ribonuclease III	Homo sapiens	71-76
24016303-6	2013	We have studied if the function of mutant PEX1, PEX6 and PEX12 can be improved by promoting protein folding using the chemical chaperone arginine.	Arginine	137-145	peroxisomal biogenesis factor 12	Homo sapiens	57-62
24049535-0	2013	Influence of L-arginine on expression of HSP70 and p-53 proteins - early biomarkers of cellular danger in renal tubular cells.	Arginine	13-23	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	41-46
24049535-0	2013	Influence of L-arginine on expression of HSP70 and p-53 proteins - early biomarkers of cellular danger in renal tubular cells.	Arginine	13-23	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	51-55
23940600-4	2013	Spectroscopic, chemical, molecular modelling and biochemical studies reported here show that the color change is mediated by selective recognition between the conjugate base of the sulfonamide group within the probe and the conjugate acid of the arginine residue within the active site of both hNAT1 and mNat2.	Arginine	246-254	N-acetyltransferase 1	Homo sapiens	294-299
23472611-6	2013	However, chickens supplemented with L-Arg had lower abdominal fat content, plasma triglyceride (TG), total cholesterol (TC) concentrations, hepatic FAS mRNA expression and increased heart carnitine palmitoyl transferase1 (CPT1) and 3-hydroxyacyl-CoA dehydrogenase (3HADH) mRNA expression.	Arginine	36-41	fatty acid synthase	Gallus gallus	148-151
23703655-2	2013	We assessed the role of cationic amino acid transporter 2 (CAT2), the inducible transporter of L-Arg, in DSS colitis.	Arginine	95-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	24-57
23703655-2	2013	We assessed the role of cationic amino acid transporter 2 (CAT2), the inducible transporter of L-Arg, in DSS colitis.	Arginine	95-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	59-63
23703655-6	2013	Clinical benefits of L-Arg supplementation in wild-type mice were lost in CAT2-/- mice.	Arginine	21-26	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	74-78
23643870-10	2013	Mutations of homologous hot-spot Arg (R140G of HspB1 and R120G of alphaB-crystallin) induced similar changes in the properties of two small heat shock proteins, whereas mutations of two neighboring residues (R140 and K141) induced different changes in the properties of HspB1.	Arginine	33-36	heat shock protein family B (small) member 1	Homo sapiens	47-52
23643870-10	2013	Mutations of homologous hot-spot Arg (R140G of HspB1 and R120G of alphaB-crystallin) induced similar changes in the properties of two small heat shock proteins, whereas mutations of two neighboring residues (R140 and K141) induced different changes in the properties of HspB1.	Arginine	33-36	heat shock protein family B (small) member 1	Homo sapiens	270-275
23884607-4	2013	Depletion of TH2B induces compensatory mechanisms that permit histone removal by up-regulating H2B and programming nucleosome instability through targeted histone modifications, including lysine crotonylation and arginine methylation.	Arginine	213-221	H2B clustered histone 1	Mus musculus	13-17
23611722-11	2013	This mutation causes leucine to be converted to arginine at position 426 belonging to a (L)RA(L)LLLKALQ highly conserved sequence in the AMH gene.	Arginine	48-56	anti-Mullerian hormone	Homo sapiens	137-140
23849627-2	2013	(2013) report their interesting discovery of a critical step for initiating BMP signal transduction that requires arginine methylation at the plasma membrane.	Arginine	114-122	bone morphogenetic protein 1	Homo sapiens	76-79
23606107-8	2013	Several potentially functional rare variants in IL23R were identified, including one nonsynonomous single-nucleotide polymorphism (nsSNP), Gly(149) Arg (position 67421184 GA on chromosome 1).	Arginine	148-151	interleukin 23 receptor	Homo sapiens	48-53
23575529-2	2013	Adenosine diphosphate ribosyl transferase 2.2 (ART2.2) utilizes extracellular NAD(+) to transfer ADP-ribose to arginine residues of extracellular domains of surface proteins.	Arginine	111-119	ADP-ribosyltransferase 2b	Mus musculus	0-45
23575529-2	2013	Adenosine diphosphate ribosyl transferase 2.2 (ART2.2) utilizes extracellular NAD(+) to transfer ADP-ribose to arginine residues of extracellular domains of surface proteins.	Arginine	111-119	ADP-ribosyltransferase 2b	Mus musculus	47-53
23253603-8	2013	Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction.	Arginine	157-165	calcium-dependent protein kinase 6	Arabidopsis thaliana	31-35
23840524-4	2013	In the "classical" pathway urea and carbon dioxide are removed from arginine by arginase and ornithine decarboxylase.	Arginine	68-76	ornithine decarboxylase 1	Rattus norvegicus	93-116
23782684-2	2013	IDH mutations are specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 or arginine 172 residue (R172) of IDH2 in gliomas.	Arginine	89-97	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-3
23782684-2	2013	IDH mutations are specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 or arginine 172 residue (R172) of IDH2 in gliomas.	Arginine	89-97	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	120-124
23782684-2	2013	IDH mutations are specific to a single codon in the conserved and functionally important arginine 132 residue (R132) of IDH1 or arginine 172 residue (R172) of IDH2 in gliomas.	Arginine	128-136	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-3
23905201-2	2010	The mutated residue in IDH1 is most commonly arginine 132, which is most often replaced with either histidine or cysteine.	Arginine	45-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	23-27
23507581-0	2013	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	Arginine	50-58	formin 1	Homo sapiens	119-122
23507581-9	2013	The weakened FMN binding may be due to conformational changes caused by the arginine mutation.	Arginine	76-84	formin 1	Homo sapiens	13-16
23507581-10	2013	Our data show that this Arg residue plays an important role in CaM binding and influences FMN binding.	Arginine	24-27	formin 1	Homo sapiens	90-93
23551821-7	2013	GluD2 mutated at a conserved arginine within the linker region connecting the ligand binding domain to the ion pore domain displays spontaneous currents that occur in the absence of agonists and are inhibited by agonist application - a behavior reminiscent of that of the previously characterized lurcher mutant.	Arginine	29-37	glutamate ionotropic receptor delta type subunit 2	Rattus norvegicus	0-5
23458873-7	2013	In contrast, a previously described NBN missense mutation, which disturbs protein folding due to the substitution of a critical arginine by tryptophan, was found to be cleared by lysosomal microautophagy leading also to lower cellular levels.	Arginine	128-136	nibrin	Homo sapiens	36-39
23499006-3	2013	Here, we show that the natural C-terminal fragments of Tau, TDP43, and alpha-synuclein are short-lived substrates of the Arg/N-end rule pathway, a processive proteolytic system that targets proteins bearing "destabilizing" N-terminal residues.	Arginine	121-124	synuclein, alpha	Mus musculus	71-86
19283063-8	2009	NAGK-20 showed higher expression at 20 degrees C, whereas NAGK-37 showed higher expression at 37 degrees C. NAGK-20 also had a lower optimal temperature for enzymatic activities and was inhibited by arginine probably as negative-feedback control.	Arginine	199-207	N-acetylglucosamine kinase	Homo sapiens	0-4
19283063-8	2009	NAGK-20 showed higher expression at 20 degrees C, whereas NAGK-37 showed higher expression at 37 degrees C. NAGK-20 also had a lower optimal temperature for enzymatic activities and was inhibited by arginine probably as negative-feedback control.	Arginine	199-207	N-acetylglucosamine kinase	Homo sapiens	58-62
19283063-8	2009	NAGK-20 showed higher expression at 20 degrees C, whereas NAGK-37 showed higher expression at 37 degrees C. NAGK-20 also had a lower optimal temperature for enzymatic activities and was inhibited by arginine probably as negative-feedback control.	Arginine	199-207	N-acetylglucosamine kinase	Homo sapiens	58-62
23499006-6	2013	The discovery that neurodegeneration-associated natural fragments of TDP43, Tau, alpha-synuclein, and APP can be selectively destroyed by the Arg/N-end rule pathway suggests that this pathway counteracts neurodegeneration.	Arginine	142-145	synuclein, alpha	Mus musculus	81-96
23524262-2	2013	IDH2 mutations are specific to a single codon in the conserved and functionally important Arginine 172 (R172) or Arginine 140 (R140).	Arginine	90-98	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	0-4
23524262-2	2013	IDH2 mutations are specific to a single codon in the conserved and functionally important Arginine 172 (R172) or Arginine 140 (R140).	Arginine	113-121	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	0-4
19040354-3	2009	First, we investigated whether PAD-4-mediated deimination is influenced by the nature of amino acid residues flanking the targeted arginine.	Arginine	131-139	peptidyl arginine deiminase 4	Homo sapiens	31-36
23574711-7	2013	Western blotting was performed to analyze the expression of ornithine transcarbamylase (OTC), an enzyme involved in L-arginine metabolism which may account for BCT-100 resistance.	Arginine	116-126	ornithine transcarbamylase	Homo sapiens	60-86
19040354-4	2009	Using two peptide substrates, residues in positions -2, -1, +1, and +2 relative to the central arginine targeted by PAD-4 were systematically replaced by all natural L-amino acids except cysteine.	Arginine	95-103	peptidyl arginine deiminase 4	Homo sapiens	116-121
19040354-8	2009	These peptides showed PAD-4 substrate behavior as predicted, demonstrating that residues flanking the targeted arginine are important for deimination.	Arginine	111-119	peptidyl arginine deiminase 4	Homo sapiens	22-27
19040354-10	2009	Finally, we observed that a methylated lysine residue flanking the targeted arginine influences PAD-4-mediated deimination, also suggesting that posttranslational modifications can affect substrate efficiency.	Arginine	76-84	peptidyl arginine deiminase 4	Homo sapiens	96-101
23574711-7	2013	Western blotting was performed to analyze the expression of ornithine transcarbamylase (OTC), an enzyme involved in L-arginine metabolism which may account for BCT-100 resistance.	Arginine	116-126	ornithine transcarbamylase	Homo sapiens	88-91
19068087-8	2009	In the analysis of the combined effects of alcohol consumption and genotype, significant impact of alcohol was seen for those subjects with ALDH2 Lys+ allele, ADH1B His/His, or ADH1C Arg/Arg (trend P = 0.077, 0.003, or 0.020, respectively), each of which is associated with a high concentration or rapid production of acetaldehyde.	Arginine	183-186	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	177-182
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Arginine	68-76	H2B clustered histone 21	Homo sapiens	80-83
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Arginine	68-76	H2B clustered histone 21	Homo sapiens	85-90
19059699-5	2009	RESULTS: A novel mutation in the thrombopoietin (TPO) receptor Mpl in HLB219 mice caused a Cys--&gt;Arg substitution at codon 40 in the extracellular region of the receptor.	Arginine	100-103	myeloproliferative leukemia virus oncogene	Mus musculus	63-66
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Arginine	68-76	galectin 1	Homo sapiens	150-154
19059699-5	2009	RESULTS: A novel mutation in the thrombopoietin (TPO) receptor Mpl in HLB219 mice caused a Cys--&gt;Arg substitution at codon 40 in the extracellular region of the receptor.	Arginine	100-103	myeloproliferative leukemia virus oncogene	Mus musculus	70-76
23417674-5	2013	Likewise, the point mutation of lysine 123 (ubiquitylation site) to arginine of H2B (H2B-K123R) also lowers the association of RNA polymerase II with GAL1, consistent with the role of H2B ubiquitylation in promoting RNA polymerase II association.	Arginine	68-76	H2B clustered histone 21	Homo sapiens	85-88
22527286-6	2013	The anti-inflammatory effects of arginine and glutamine were associated with decreased activation levels of signaling molecules known to be involved in mast cell cytokine expression such as MAPK family members extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, and the protein kinase B (Akt).	Arginine	33-41	protein tyrosine kinase 2 beta	Homo sapiens	291-307
19185003-3	2009	The archetypal PPIase is the human cyclophilin 18 (Cyp18 or CypA), and Arg 55 has been demonstrated to play a crucial role when studying short peptide substrates in the catalytic action of Cyp18 by stabilizing the transition state of isomerization.	Arginine	71-74	peptidylprolyl isomerase A	Homo sapiens	60-64
23264629-5	2013	Cytosolic IDH1 Arg-132 mutations, although structurally analogous to mutations at mitochondrial IDH2 Arg-172, were only able to elevate intracellular 2HG to comparable levels when an equivalent level of wild-type IDH1 was co-expressed.	Arginine	15-18	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	10-14
19010776-5	2009	Mutation of Arg-150 in factor Xa, which interacts with the exosite residues in heparin-activated antithrombin, abrogated the ability of the engineered exosites in alpha1PI to promote factor Xa inhibition.	Arginine	12-15	serpin family C member 1	Homo sapiens	97-109
23264629-5	2013	Cytosolic IDH1 Arg-132 mutations, although structurally analogous to mutations at mitochondrial IDH2 Arg-172, were only able to elevate intracellular 2HG to comparable levels when an equivalent level of wild-type IDH1 was co-expressed.	Arginine	15-18	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	213-217
18984580-3	2009	Based on the high resolution crystal structure of human leukotriene C4 synthase, a model of mPGES-1 has been constructed in which the tripeptide co-substrate glutathione is bound in a horseshoe-shaped conformation with its thiol group positioned in close proximity to Arg-126.	Arginine	268-271	prostaglandin E synthase	Mus musculus	92-99
18984580-6	2009	Our data show that Arg-126 is a catalytic residue in mPGES-1 and suggest that MAPEG enzymes share significant structural components of their active sites.	Arginine	19-22	prostaglandin E synthase	Mus musculus	53-60
23264629-5	2013	Cytosolic IDH1 Arg-132 mutations, although structurally analogous to mutations at mitochondrial IDH2 Arg-172, were only able to elevate intracellular 2HG to comparable levels when an equivalent level of wild-type IDH1 was co-expressed.	Arginine	101-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	10-14
22714012-1	2013	GPRC6A is a seven-transmembrane receptor activated by a wide range of L-alpha-amino acids, most potently by L-arginine and other basic amino acids.	Arginine	108-118	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
19557313-0	2009	Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C.	Arginine	0-8	serine and arginine rich splicing factor 9	Homo sapiens	68-73
19557313-0	2009	Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C.	Arginine	0-8	serine and arginine rich splicing factor 9	Homo sapiens	74-80
19557313-3	2009	In this study, we found that SFRS9 is a target for PRMT1-mediated arginine methylation in vitro, and that it is immunoprecipitated from HEK-293 lysates by antibodies that recognize both mono- and dimethylated arginines.	Arginine	66-74	serine and arginine rich splicing factor 9	Homo sapiens	29-34
19557313-3	2009	In this study, we found that SFRS9 is a target for PRMT1-mediated arginine methylation in vitro, and that it is immunoprecipitated from HEK-293 lysates by antibodies that recognize both mono- and dimethylated arginines.	Arginine	209-218	serine and arginine rich splicing factor 9	Homo sapiens	29-34
19557313-6	2009	Our findings indicate the importance of arginine methylation for the subnuclear localization of SFRS9.	Arginine	40-48	serine and arginine rich splicing factor 9	Homo sapiens	96-101
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Arginine	113-121	serpin family C member 1	Homo sapiens	47-52
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Arginine	113-121	serpin family C member 1	Homo sapiens	107-112
20069060-5	2009	The level of fat oxidation at rest and aerobic exercise of the male subjects with Trp/Arg of the beta3-AR gene was significantly lower than that of the Trp/Trp genotype.	Arginine	86-89	adrenoceptor beta 3	Homo sapiens	97-105
19136629-0	2009	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	protein inhibitor of activated STAT 1	Homo sapiens	39-44
19136629-4	2009	PIAS1 is arginine methylated by PRMT1 in vitro as well as in vivo upon IFN treatment.	Arginine	9-17	protein inhibitor of activated STAT 1	Homo sapiens	0-5
19136629-5	2009	Mutational and mass spectrometric analysis of PIAS1 identifies Arg 303 as the single methylation site.	Arginine	63-66	protein inhibitor of activated STAT 1	Homo sapiens	46-51
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	protein inhibitor of activated STAT 1	Homo sapiens	105-110
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	protein inhibitor of activated STAT 1	Homo sapiens	219-224
19857286-4	2009	The mutation concerns a polymorphism in exon 2 that predicts the substitution of tryptophan at position 59 of the VKOR protein by arginine, the p.Trp59Arg mutation.	Arginine	130-138	vitamin K epoxide reductase complex subunit 1	Homo sapiens	114-118
18977201-3	2008	The C-terminal cytoplasmic (C-ter) domain of GPR54 contains a segment rich in proline and arginine residues that corresponds to the primary structure of four overlapping SH3 binding motifs.	Arginine	90-98	KISS1 receptor	Homo sapiens	45-50
18952056-5	2008	These results suggest that the sorting signal for lysosomes is present within the amino-terminal transmembrane domain (Met(1)-Arg(141)) of the TAPL molecule.	Arginine	126-129	ATP binding cassette subfamily B member 9	Homo sapiens	143-147
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	158-161	ret proto-oncogene	Homo sapiens	84-87
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	158-161	ret proto-oncogene	Homo sapiens	109-112
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	84-87
18845535-9	2008	Furthermore, we have shown by mutagenesis and enzyme-linked immunosorbent assays of RET phosphorylation that RET probably interacts with GFR alpha 1 residues Arg-190, Lys-194, Arg-197, Gln-198, Lys-202, Arg-257, Arg-259, Glu-323, and Asp-324 upon both domains 2 and 3.	Arginine	176-179	ret proto-oncogene	Homo sapiens	109-112
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Arginine	133-136	complement C1q A chain	Homo sapiens	54-57
18840401-1	2008	Argininosuccinate synthetase (ASS), a key enzyme in the urea cycle, participates in many metabolic processes including arginine biosynthesis and the citrulline-nitric oxide (NO) cycle.	Arginine	119-127	argininosuccinate synthase 1	Homo sapiens	0-28
18840401-1	2008	Argininosuccinate synthetase (ASS), a key enzyme in the urea cycle, participates in many metabolic processes including arginine biosynthesis and the citrulline-nitric oxide (NO) cycle.	Arginine	119-127	argininosuccinate synthase 1	Homo sapiens	30-33
19018669-7	2008	Reconstitution of Cys239, using site-directed mutagenesis, restored CD4 binding, while introducing Arg or Ser into position 239 of the functional Du151 gp120 protein abrogated CD4 binding.	Arginine	99-102	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	152-157
18948218-4	2008	Interestingly only arginine reduced the area of p53 expression both in explants of mature and immature spleen tissue.	Arginine	19-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	48-51
18948218-5	2008	The ability of arginine to reduce p53 expression can be suggested as one of the mechanisms of the tumor growth stimulation.	Arginine	15-23	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	34-37
18829457-0	2008	A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.	Arginine	12-20	lysine methyltransferase 2A	Homo sapiens	93-125
18829457-6	2008	Our studies reveal that WDR5 preferentially recognizes a previously unidentified and conserved arginine-containing motif, called the "Win" or WDR5 interaction motif, which is located in the N-SET region of MLL1 and other SET1 family members.	Arginine	95-103	lysine methyltransferase 2A	Homo sapiens	206-210
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	78-86	lysine methyltransferase 2A	Homo sapiens	99-103
18829457-7	2008	Surprisingly, our structural and functional studies show that WDR5 recognizes arginine 3765 of the MLL1 Win motif using the same arginine binding pocket on WDR5 that was previously shown to bind histone H3.	Arginine	129-137	lysine methyltransferase 2A	Homo sapiens	99-103
18829457-8	2008	We demonstrate that WDR5"s recognition of arginine 3765 of MLL1 is essential for the assembly and enzymatic activity of the MLL1 core complex in vitro.	Arginine	42-50	lysine methyltransferase 2A	Homo sapiens	59-63
18829457-8	2008	We demonstrate that WDR5"s recognition of arginine 3765 of MLL1 is essential for the assembly and enzymatic activity of the MLL1 core complex in vitro.	Arginine	42-50	lysine methyltransferase 2A	Homo sapiens	124-128
18829459-2	2008	In the accompanying investigation, we describe the identification of a conserved arginine containing motif, called the "Win" or WDR5 interaction motif, that is essential for the assembly and H3K4 dimethylation activity of the MLL1 core complex.	Arginine	81-89	lysine methyltransferase 2A	Homo sapiens	226-230
18829459-4	2008	Our results show that Arg-3765 of MLL1 is bound in the same arginine binding pocket on WDR5 that was previously suggested to bind histone H3.	Arginine	22-25	lysine methyltransferase 2A	Homo sapiens	34-38
18829459-4	2008	Our results show that Arg-3765 of MLL1 is bound in the same arginine binding pocket on WDR5 that was previously suggested to bind histone H3.	Arginine	60-68	lysine methyltransferase 2A	Homo sapiens	34-38
18829459-6	2008	These results are consistent with a model in which WDR5 recognizes Arg-3765 of MLL1, which is essential for the assembly and enzymatic activity of the MLL1 core complex.	Arginine	67-70	lysine methyltransferase 2A	Homo sapiens	79-83
18829459-6	2008	These results are consistent with a model in which WDR5 recognizes Arg-3765 of MLL1, which is essential for the assembly and enzymatic activity of the MLL1 core complex.	Arginine	67-70	lysine methyltransferase 2A	Homo sapiens	151-155
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	13-16	regulator of G protein signaling 8	Homo sapiens	157-161
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	13-16	regulator of G protein signaling 8	Homo sapiens	185-189
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	26-29	regulator of G protein signaling 8	Homo sapiens	157-161
18760349-9	2008	Furthermore, Arg(253) and Arg(256) at the distal end of the i3 loop were found to comprise a structurally important site for the functional interaction with RGS8, since coexpression of RGS8 with R253Q/R256Q mutant receptors resulted in a loss of induction of MCH-stimulated calcium mobilization.	Arginine	26-29	regulator of G protein signaling 8	Homo sapiens	185-189
18687868-2	2008	Previous crystallographic studies of Efb-C bound to its cognate subdomain of human C3 (C3d) identified Arg-131 and Asn-138 of Efb-C as key residues for its activity.	Arginine	103-106	endogenous retrovirus group K member 13	Homo sapiens	83-90
18658131-2	2008	The interactions between the two proteins have been attributed primarily to binding of the somatomedin B (SMB) domain, which comprises the N-terminal 44 residues of vitronectin, to the flexible joint region of PAI-1, including residues Arg-103, Met-112, and Gln-125 of PAI-1.	Arginine	236-239	serpin family E member 1	Homo sapiens	210-215
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	8-16	ribonucleotide reductase regulatory subunit M2	Homo sapiens	213-217
18854029-8	2008	Upon ectopic expression in C-33A cells, recombinant chicken ART4 localized at the cell surface as a GPI-anchored, highly glycosylated protein, which displayed arginine-specific ART activity (apparent Km of the recombinant protein for etheno-NAD+ 1.0 +/- 0.18 microM).	Arginine	159-167	ADP-ribosyltransferase 4	Gallus gallus	60-64
23172304-3	2013	Mutations at the P1 (Arg(15)) site in combination with P2" (Met(17)) mutations profoundly affect inhibition of FXIa, plasmin, kallikrein, factor Xa and thrombin.	Arginine	21-24	kallikrein 1-related peptidase b9	Mus musculus	126-136
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	programmed cell death 6 interacting protein	Homo sapiens	191-195
18650441-2	2008	We employed crystallographic and functional studies to investigate whether the exchange of arginine to citrulline affects the display of a peptide by two human major histocompatibility antigen class I subtypes, HLA-B(*)2705 and HLA-B(*)2709.	Arginine	91-99	major histocompatibility complex, class I, B	Homo sapiens	211-216
23365224-8	2013	Spine destabilization in Arg knockdown neurons is prevented by blocking NMDA receptor-dependent relocalization of cortactin from spines, or by forcing cortactin into spines via fusion to an actin-binding region of Arg.	Arginine	25-28	cortactin	Mus musculus	114-123
18827054-4	2008	In general, removal of Arg residues reduces affinity for anionic PL and beta(2)GPI.	Arginine	23-26	apolipoprotein H	Homo sapiens	72-82
23365224-8	2013	Spine destabilization in Arg knockdown neurons is prevented by blocking NMDA receptor-dependent relocalization of cortactin from spines, or by forcing cortactin into spines via fusion to an actin-binding region of Arg.	Arginine	25-28	cortactin	Mus musculus	151-160
23365224-9	2013	Thus, Arg employs distinct mechanisms to selectively regulate spine and dendrite stability: Arg dampens activity-dependent disruption of cortactin localization to stabilize spines and attenuates Rho activity to stabilize dendrite arbors.	Arginine	6-9	cortactin	Mus musculus	137-146
23365224-9	2013	Thus, Arg employs distinct mechanisms to selectively regulate spine and dendrite stability: Arg dampens activity-dependent disruption of cortactin localization to stabilize spines and attenuates Rho activity to stabilize dendrite arbors.	Arginine	92-95	cortactin	Mus musculus	137-146
23328665-1	2013	Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures and cell lines.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	130-134
18498758-10	2008	Subsequently replacing ARG8(m) with mutated versions of cytochrome b results in arginine auxotrophy.	Arginine	80-88	acetylornithine transaminase	Saccharomyces cerevisiae S288C	23-27
24804122-11	2013	Biochemical testing revealed previously undiagnosed ornithine transcarbamylase deficiency, and the patient responded to arginine, sodium phenylacetate, and sodium benzoate.	Arginine	120-128	ornithine transcarbamylase	Homo sapiens	52-78
23948919-12	2013	Genetic testing revealed a heterozygous guanine to cytosine mutation at the first base of codon 389 (Exon 13) of MAPT, the tau gene, resulting in a glycine to arginine substitution, in the patient and her non-affected father.	Arginine	159-167	microtubule associated protein tau	Homo sapiens	113-117
18559978-0	2008	A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function.	Arginine	140-143	solute carrier family 46 member 1	Homo sapiens	41-74
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	protein arginine methyltransferase 8	Homo sapiens	214-219
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	protein arginine methyltransferase 8	Homo sapiens	214-219
23948919-12	2013	Genetic testing revealed a heterozygous guanine to cytosine mutation at the first base of codon 389 (Exon 13) of MAPT, the tau gene, resulting in a glycine to arginine substitution, in the patient and her non-affected father.	Arginine	159-167	microtubule associated protein tau	Homo sapiens	123-126
18652489-6	2008	Here, we dissect this specificity with biochemical and X-ray crystallographic analysis of APPBP1-UBA3-NEDD8 complexes in which NEDD8"s residue 72 and UBA3"s residue 190 are substituted with different combinations of Ala, Arg, or Gln.	Arginine	221-224	NEDD8 activating enzyme E1 subunit 1	Homo sapiens	90-96
22858580-7	2013	Analysis of the cgUbiquitin C-terminus by carboxypeptidase B treatment and comparison of the retention times revealed that cgUbiquitin lacks the terminal Gly-Gly doublet and ends in an C-terminal Arg residue which might be related to antimicrobial activity.	Arginine	196-199	carboxypeptidase B	Crassostrea gigas	42-60
18636753-2	2008	Eighty to ninety percent of the arginine methylation in the cell is performed by the protein arginine methyl transferase PRMT1.	Arginine	32-40	protein arginine methyltransferase 1 L homeolog	Xenopus laevis	121-126
23443546-8	2013	In the C4 phosphoenolpyruvate carboxylase isoform, this arginine is replaced by glycine.	Arginine	56-64	phosphoenolpyruvate carboxykinase 1	Homo sapiens	10-41
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	274-277	serpin family C member 1	Homo sapiens	41-43
18510673-8	2008	The association between MC1R variants and childhood tanning tendency was similar in both p53 Arg/Arg genotype and Pro allele carriers (Arg/Pro or Pro/Pro).	Arginine	93-96	melanocortin 1 receptor	Homo sapiens	24-28
18586266-7	2008	Comparison of the three-dimensional solution structures of CD2 alone and in complex with cpSRP54(pep) shows that significant structural changes are induced in CD2 in order to establish a binding interface contributed mostly by residues in the N-terminal segment of CD2 (Phe5-Val10) and an arginine doublet (Arg536 and Arg537) in the cpSRP54 peptide.	Arginine	289-297	progestagen associated endometrial protein	Homo sapiens	89-101
18477475-4	2008	Introduction of lysine-to-arginine mutations into the bHLH domain led to stabilization of Hes7 protein and to abnormalities in either the N box-binding activity or partner preference in heterodimer formation.	Arginine	26-34	hes family bHLH transcription factor 7	Homo sapiens	90-94
18495660-1	2008	The mammalian nuclear poly(A)-binding protein, PABPN1, carries 13 asymmetrically dimethylated arginine residues in its C-terminal domain.	Arginine	94-102	poly(A) binding protein nuclear 1	Homo sapiens	47-53
18570440-5	2008	A nearby arginine residue (R48) participates in a guanidinium stacking interaction with R28 from the other monomer in the DJ-1 dimer and elevates the p K a of C106 by binding an anion that electrostatically suppresses thiol ionization.	Arginine	9-17	Parkinsonism associated deglycase	Homo sapiens	122-126
18594222-13	2008	Equimolar administration of L-arginine resulted in lower pancreatic weight/body weight ratio, pancreatic myeloperoxidase activity, and histologic damage compared with the L-ornithine-treated group.	Arginine	28-38	myeloperoxidase	Rattus norvegicus	105-120
18562501-3	2008	In the present study, we have performed an arginine scan of residues in the pore loop of the GluR6(Q) subunit.	Arginine	43-51	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	93-98
18562501-4	2008	Amino acids within the range from -19 to +7 of the Q/R site of GluR6(Q) were individually mutated to arginine and the mutant cDNAs were expressed as homomeric channels in HEK 293 cells.	Arginine	101-109	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	63-68
18562501-7	2008	However, arginine substitution at several locations upstream of the Q/R site resulted in homomeric channels exhibiting strong inhibition by fatty acids, which is characteristic of homomeric GluR6(R) channels.	Arginine	9-17	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	190-195
18383559-5	2008	Activation of sympathetic-corticotropin-releasing hormone (CRH) axis by psychological stress induces specifically Th1 cell overactivity that determines enhanced glutamine utilization and consequent poor L-arginine supply for nitric oxide (NO)-assisted insulin secretion.	Arginine	203-213	corticotropin releasing hormone	Homo sapiens	14-57
18383559-5	2008	Activation of sympathetic-corticotropin-releasing hormone (CRH) axis by psychological stress induces specifically Th1 cell overactivity that determines enhanced glutamine utilization and consequent poor L-arginine supply for nitric oxide (NO)-assisted insulin secretion.	Arginine	203-213	corticotropin releasing hormone	Homo sapiens	59-62
18384376-3	2008	Phosphorylation of 4E-BP1 requires an additional feature, termed the RAIP motif (Arg-Ala-Ile-Pro).	Arginine	81-84	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	19-25
18424593-7	2008	The arginine treatment enhanced the formation of the active eIF4E x eIF4G complex but reduced the amount of the inactive 4E-BP1 x eIF4E complex in muscle.	Arginine	4-12	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	121-127
18424593-8	2008	These changes were associated with elevated levels of phosphorylated mTOR and 4E-BP1 in muscle of arginine-supplemented piglets (P &lt; 0.05).	Arginine	98-106	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	78-84
18347055-3	2008	The sites of IRAK-1 ubiquitination were mapped to Lys134 and Lys180, and arginine substitution of these residues impaired IL-1R/TLR-mediated IRAK-1 ubiquitination, NEMO binding, and NF-kappaB activation.	Arginine	73-81	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	164-168
18339322-2	2008	We have developed peptides carrying amino acid substitutions along the Ser(88)-Arg-Ser-Arg-Tyr(92) (SRSRY) uPAR chemotactic sequence.	Arginine	79-82	plasminogen activator, urokinase receptor	Homo sapiens	107-111
18339322-2	2008	We have developed peptides carrying amino acid substitutions along the Ser(88)-Arg-Ser-Arg-Tyr(92) (SRSRY) uPAR chemotactic sequence.	Arginine	87-90	plasminogen activator, urokinase receptor	Homo sapiens	107-111
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	274-277	serpin family C member 1	Homo sapiens	120-122
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	274-277	serpin family C member 1	Homo sapiens	120-122
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	274-277	serpin family C member 1	Homo sapiens	120-122
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	303-306	serpin family C member 1	Homo sapiens	41-43
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	303-306	serpin family C member 1	Homo sapiens	120-122
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	303-306	serpin family C member 1	Homo sapiens	120-122
23578459-6	2013	RESULTS: Compared to the wild-types, the AT expression of HEK293T cells sharply increased when they were transfected by AT-c.342T &gt; G or AT-c.134G &gt; A and c.342T &gt; G. Homology modeling showed that the mutation (AT-c.342T &gt; G) caused a decreased distance between Arg and surrounding bases as Arg"s side chain was significantly longer than Ser"s.	Arginine	303-306	serpin family C member 1	Homo sapiens	120-122
23159736-1	2012	Deamidation of N-terminal Gln by the Ntaq1 Nt(Q)-amidase is a part of the Arg/N-end rule pathway, a ubiquitin-dependent proteolytic system.	Arginine	74-77	N-terminal glutamine amidase 1	Homo sapiens	43-56
23159736-2	2012	Here we identify Gln-Usp1(Ct), the C-terminal fragment of the autocleaved Usp1 deubiquitylase, as the first physiological Arg/N-end rule substrate that is targeted for degradation through deamidation of N-terminal Gln.	Arginine	122-125	ubiquitin specific peptidase 1	Homo sapiens	21-25
23159736-2	2012	Here we identify Gln-Usp1(Ct), the C-terminal fragment of the autocleaved Usp1 deubiquitylase, as the first physiological Arg/N-end rule substrate that is targeted for degradation through deamidation of N-terminal Gln.	Arginine	122-125	ubiquitin specific peptidase 1	Homo sapiens	74-78
23159736-4	2012	The autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the Gln-Usp1(Ct) fragment is selectively destroyed by the Arg/N-end rule pathway.	Arginine	191-194	ubiquitin specific peptidase 1	Homo sapiens	16-20
23159736-6	2012	Thus, in addition to its other functions in DNA repair and chromosome segregation, the Arg/N-end rule pathway regulates genomic stability through the degradation-mediated control of the autocleaved Usp1 deubiquitylase.	Arginine	87-90	ubiquitin specific peptidase 1	Homo sapiens	198-202
23135270-2	2012	Another proprotein convertase, furin, cleaves PCSK9 at Arg(218)-Gln(219) in the surface-exposed "218 loop."	Arginine	55-58	proprotein convertase subtilisin/kexin type 9	Mus musculus	46-51
23135270-6	2012	Hepsin cleaves PCSK9 at Arg(218)-Gln(219) more efficiently than furin but also cleaves at Arg(215)-Phe(216).	Arginine	24-27	proprotein convertase subtilisin/kexin type 9	Mus musculus	15-20
23043454-1	2012	Chlamydia pneumoniae encodes a functional arginine decarboxylase (ArgDC), AaxB, that activates upon self-cleavage and converts l-arginine to agmatine.	Arginine	127-137	antizyme inhibitor 2	Homo sapiens	42-64
23051648-3	2012	Several independent unc-17 alleles are associated with a glycine-to-arginine substitution (G347R), which introduces a positive charge in the ninth transmembrane domain (TMD) of UNC-17.	Arginine	68-76	Vesicular acetylcholine transporter unc-17	Caenorhabditis elegans	20-26
17922141-2	2008	CPM hydrolyses the C-terminal arginine of epidermal growth factor (EGF) resulting in des-Arg53-EGF which binds to the EGF receptor (EGFR) with an equal or greater affinity than native EGF.	Arginine	30-38	epidermal growth factor	Homo sapiens	42-65
23051648-3	2012	Several independent unc-17 alleles are associated with a glycine-to-arginine substitution (G347R), which introduces a positive charge in the ninth transmembrane domain (TMD) of UNC-17.	Arginine	68-76	Vesicular acetylcholine transporter unc-17	Caenorhabditis elegans	177-183
23090985-1	2012	The arginine 132 (R132) mutation of isocitrate dehydrogenase -1 (IDH1(R132)) results in production of 2-hydroxyglutarate (2-HG) and is associated with a better prognosis compared with wild-type (WT) in glioma patients.	Arginine	4-12	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	65-69
18393249-5	2008	There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively.	Arginine	202-205	8-oxoguanine DNA glycosylase	Homo sapiens	127-132
18316480-3	2008	We show that RUNX1 is arginine-methylated in vivo by the arginine methyltransferase PRMT1, and that PRMT1 serves as a transcriptional coactivator for RUNX1 function.	Arginine	22-30	RUNX family transcription factor 1	Homo sapiens	13-18
18316480-4	2008	Using mass spectrometry, and a methyl-arginine-specific antibody, we identified two arginine residues (R206 and R210) within the region of RUNX1 that interact with the corepressor SIN3A and are methylated by PRMT1.	Arginine	38-46	RUNX family transcription factor 1	Homo sapiens	139-144
18316480-4	2008	Using mass spectrometry, and a methyl-arginine-specific antibody, we identified two arginine residues (R206 and R210) within the region of RUNX1 that interact with the corepressor SIN3A and are methylated by PRMT1.	Arginine	38-46	SIN3 transcription regulator family member A	Homo sapiens	180-185
23104059-2	2012	Fusogenic trans-SNARE complexes are assembled from glutamine-contributing SNAREs (Q-SNAREs) embedded in one membrane and an arginine-contributing SNARE (R-SNARE) embedded in the other.	Arginine	124-132	YKT6 v-SNARE homolog	Homo sapiens	16-21
22917549-2	2012	Argininosuccinate synthetase (ASS) is the rate-limiting enzyme for de novo arginine production.	Arginine	75-83	argininosuccinate synthase 1	Homo sapiens	0-28
18316480-4	2008	Using mass spectrometry, and a methyl-arginine-specific antibody, we identified two arginine residues (R206 and R210) within the region of RUNX1 that interact with the corepressor SIN3A and are methylated by PRMT1.	Arginine	84-92	RUNX family transcription factor 1	Homo sapiens	139-144
18316480-4	2008	Using mass spectrometry, and a methyl-arginine-specific antibody, we identified two arginine residues (R206 and R210) within the region of RUNX1 that interact with the corepressor SIN3A and are methylated by PRMT1.	Arginine	84-92	SIN3 transcription regulator family member A	Homo sapiens	180-185
18316480-5	2008	PRMT1- dependent methylation of RUNX1 at these arginine residues abrogates its association with SIN3A, whereas shRNA against PRMT1 (or use of a methyltransferase inhibitor) enhances this association.	Arginine	47-55	RUNX family transcription factor 1	Homo sapiens	32-37
18316480-5	2008	PRMT1- dependent methylation of RUNX1 at these arginine residues abrogates its association with SIN3A, whereas shRNA against PRMT1 (or use of a methyltransferase inhibitor) enhances this association.	Arginine	47-55	SIN3 transcription regulator family member A	Homo sapiens	96-101
18316480-6	2008	We find arginine-methylated RUNX1 on the promoters of two bona fide RUNX1 target genes, CD41 and PU.1 and show that shRNA against PRMT1 or RUNX1 down-regulates their expression.	Arginine	8-16	RUNX family transcription factor 1	Homo sapiens	28-33
18316480-6	2008	We find arginine-methylated RUNX1 on the promoters of two bona fide RUNX1 target genes, CD41 and PU.1 and show that shRNA against PRMT1 or RUNX1 down-regulates their expression.	Arginine	8-16	RUNX family transcription factor 1	Homo sapiens	68-73
22917549-2	2012	Argininosuccinate synthetase (ASS) is the rate-limiting enzyme for de novo arginine production.	Arginine	75-83	argininosuccinate synthase 1	Homo sapiens	30-33
18316480-6	2008	We find arginine-methylated RUNX1 on the promoters of two bona fide RUNX1 target genes, CD41 and PU.1 and show that shRNA against PRMT1 or RUNX1 down-regulates their expression.	Arginine	8-16	RUNX family transcription factor 1	Homo sapiens	68-73
23048028-0	2012	A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.	Arginine	19-27	signal recognition particle 72	Homo sapiens	171-176
18316480-7	2008	These arginine methylation sites and the dynamic regulation of corepressor binding are lost in the leukemia-associated RUNX1-ETO fusion protein, which likely contributes to its dominant inhibitory activity.	Arginine	6-14	RUNX family transcription factor 1	Homo sapiens	119-124
18083705-4	2008	By two-dimensional PAGE-Western blot analyses using a modified citrulline antibody, we discovered that more than half of the arginine residues of native S100A3 are progressively converted to citrullines by Ca2+-dependent peptidylarginine deiminases.	Arginine	125-133	S100 calcium binding protein A3	Homo sapiens	153-159
23170937-7	2012	Replacing the corresponding Arg in type I and type III SUTs, AtSUC1(R163K) and LjSUT4(R169K), respectively, also resulted in loss of sucrose transport activity.	Arginine	28-31	sucrose-proton symporter 1	Arabidopsis thaliana	61-67
18083705-6	2008	Recombinant PAD1 and PAD2 are capable of converting all 4 arginines in recombinant S100A3, whereas PAD3 specifically converts only Arg-51 into citrulline.	Arginine	58-67	peptidyl arginine deiminase 1	Homo sapiens	12-16
18083705-6	2008	Recombinant PAD1 and PAD2 are capable of converting all 4 arginines in recombinant S100A3, whereas PAD3 specifically converts only Arg-51 into citrulline.	Arginine	58-67	S100 calcium binding protein A3	Homo sapiens	83-89
18083705-6	2008	Recombinant PAD1 and PAD2 are capable of converting all 4 arginines in recombinant S100A3, whereas PAD3 specifically converts only Arg-51 into citrulline.	Arginine	131-134	peptidyl arginine deiminase 1	Homo sapiens	12-16
18083705-7	2008	Gel filtration analyses showed that either enzymatic conversion of Arg-51 in S100A3 to citrulline or its mutational substitution with alanine (R51A) promotes a homotetramer assembly.	Arginine	67-70	S100 calcium binding protein A3	Homo sapiens	77-83
22968170-4	2012	Here, we show that arginine methylation modulates nuclear import of FUS via a novel TRN-binding epitope.	Arginine	19-27	transportin 1	Homo sapiens	84-87
18083711-7	2008	Molecular modeling supports the conclusion that Arg(10) in the D domain of caspase-9 interacts with Asp(160) in the TTCD motif of ERK2.	Arginine	48-51	caspase 9	Homo sapiens	75-84
22968170-5	2012	Chemical or genetic inhibition of arginine methylation restores TRN-mediated nuclear import of ALS-associated FUS mutants.	Arginine	34-42	transportin 1	Homo sapiens	64-67
22968170-6	2012	The unmethylated arginine-glycine-glycine domain preceding the PY-NLS interacts with TRN and arginine methylation in this domain reduces TRN binding.	Arginine	17-25	transportin 1	Homo sapiens	85-88
22968170-6	2012	The unmethylated arginine-glycine-glycine domain preceding the PY-NLS interacts with TRN and arginine methylation in this domain reduces TRN binding.	Arginine	17-25	transportin 1	Homo sapiens	137-140
18031293-6	2008	C3178T encodes an arginine to tryptophan (R1060W) substitution in the TSP1-7 domain of ADAMTS-13.	Arginine	18-26	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	87-96
22968170-6	2012	The unmethylated arginine-glycine-glycine domain preceding the PY-NLS interacts with TRN and arginine methylation in this domain reduces TRN binding.	Arginine	93-101	transportin 1	Homo sapiens	137-140
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	43-46	apolipoprotein A2	Homo sapiens	113-119
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	43-46	apolipoprotein A2	Homo sapiens	250-256
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	113-119
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	250-256
23166959-6	2004	A radiolabeled linear peptide that has a high affinity for the uPAR, AE105 (Asp-Cha-Phe-(d)Ser-(d)Arg-Tyr-Leu-Trp-Ser-CONH2), is considered to be the most promising ligand for the detection and imaging of cancerous tissues that overexpress the uPAR (1).	Arginine	98-101	plasminogen activator, urokinase receptor	Homo sapiens	63-67
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	113-119
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	250-256
22992733-6	2012	Arg82 has been extensively studied as part of the transcriptional complex regulating nitrogen sensing, in particular arginine metabolism.	Arginine	117-125	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-5
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	113-119
18247304-6	2008	In normal controls, subjects with genotype Arg/Arg had a higher concentration of serum TG and apoB100, and lower apoAII levels, when compared with those with genotypes Arg/Gly or Gly/Gly, respectively (vs. Arg/Gly for TG, vs. Gly/Gly for apoB100 and apoAII, respectively, P&lt;0.05).	Arginine	47-50	apolipoprotein A2	Homo sapiens	250-256
18172323-5	2008	Upon estrogen stimulation, the E2F1 promoter is subject to CARM1-dependent dimethylation on histone H3 arginine 17 (H3R17me2) in a process that parallels the recruitment of ER alpha.	Arginine	103-111	E2F transcription factor 1	Homo sapiens	31-35
22992733-8	2012	In this study, we developed a novel method for the real time study of promoter strength in vivo and used it to demonstrate that catalytically inactive Arg82 fully restored the arginine-dependent transcriptional response.	Arginine	176-184	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	151-156
22865229-2	2012	IL-4-induced activation of macrophages produced arginase-1, which converts arginine into ornithine, a precursor of polyamines and proline.	Arginine	75-83	interleukin 4	Mus musculus	0-4
18638502-6	2008	TSR domains of the three trout properdin isoforms seem to adopt the folding pattern of human thrombospondin 1 TSP-1 domains, where each TSP-1 domain forms an antiparallel three-stranded structure that consists of alternative stacked layers of Trp and Arg residues from respective strands capped by disulfide bonds on each end.	Arginine	251-254	complement factor properdin L homeolog	Xenopus laevis	31-40
17971302-5	2007	Inhibition of arginine methylation with MTA or PRMT1-siRNA diminished later phase of insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and IRS-1, association of IRS-1 with p85alpha subunit of PI3-K, and glucose uptake.	Arginine	14-22	insulin receptor substrate 1	Homo sapiens	163-168
17971302-5	2007	Inhibition of arginine methylation with MTA or PRMT1-siRNA diminished later phase of insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and IRS-1, association of IRS-1 with p85alpha subunit of PI3-K, and glucose uptake.	Arginine	14-22	insulin receptor substrate 1	Homo sapiens	185-190
22269898-7	2012	Serum nitrate/nitrite (NOx) and interleukin (IL)-2 levels were significantly decreased by arginine in a dose-dependent manner.	Arginine	90-98	interleukin 2	Rattus norvegicus	32-50
17631366-6	2007	L-arginine attenuated the decrease in food intake induced by leptin.	Arginine	0-10	leptin	Gallus gallus	61-67
22269898-8	2012	Animals supplemented with parenteral arginine had significantly decreased productions of concanavalin (Con) A- and lipopolysaccharide (LPS)-stimulated TNF-alpha in PBLs and splenocytes, spontaneous IL-6 and LPS-stimulated IFN-gamma in PBLs, and LPS-stimulated IL-6 in splenocytes.	Arginine	37-45	interferon gamma	Rattus norvegicus	222-231
22269898-9	2012	In addition, low-dose arginine significantly increased production of spontaneous IFN-gamma in PBLs and splenocytes.	Arginine	22-30	interferon gamma	Rattus norvegicus	81-90
18067781-8	2007	Plasma cardiac troponin I levels were higher and the areas of hydropic changes were larger in control group than in ARG and ADO groups.	Arginine	116-119	troponin I3, cardiac type	Canis lupus familiaris	7-25
22327565-8	2012	Administration of L-arginine to obese ewes increased arginine and ornithine concentrations in maternal and fetal plasma, amniotic fluid volume, protein content in maternal carcass, and fetal brown adipose tissue (+60%), while reducing maternal lipid content and circulating leptin levels.	Arginine	18-28	leptin	Ovis aries	274-280
18067781-9	2007	Combination of arginine and adenosine provided further myoprotection with respect to better cardiac performance, lower release of cardiac troponin I, and smaller areas of hydropic changes compared with ARG and ADO groups.	Arginine	15-23	troponin I3, cardiac type	Canis lupus familiaris	130-148
22327565-8	2012	Administration of L-arginine to obese ewes increased arginine and ornithine concentrations in maternal and fetal plasma, amniotic fluid volume, protein content in maternal carcass, and fetal brown adipose tissue (+60%), while reducing maternal lipid content and circulating leptin levels.	Arginine	20-28	leptin	Ovis aries	274-280
22831553-0	2012	Synthesis and biological evaluation of a novel (177)Lu-DOTA-[Gly(3)-cyclized(Dap(4), (d)-Phe(7), Asp(10))-Arg(11)]alpha-MSH(3-13) analogue for melanocortin-1 receptor-positive tumor targeting.	Arginine	106-109	melanocortin 1 receptor	Homo sapiens	143-166
17927214-3	2007	A structure-based sequence alignment predicts that domain 5 contains the four conserved residues (Gln, Arg, Glu, Tyr) identified as essential for Man-6-P binding by the CD-MPR and domains 1-3 and 9 of the CI-MPR.	Arginine	103-106	mannose-6-phosphate receptor, cation dependent	Homo sapiens	169-175
22872579-0	2012	GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets.	Arginine	31-41	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
22872579-2	2012	The possibility that l-Arg regulates insulin secretion through a G protein-coupled receptor (GPCR)-mediated mechanism is suggested by the high expression of the nutrient receptor GPCR family C group 6 member A (GPRC6A) in the pancreas and TC-6 beta-cells and the finding that Gprc6a(-/]minus]) mice have abnormalities in glucose homeostasis.	Arginine	21-26	G protein-coupled receptor, family C, group 6, member A	Mus musculus	211-217
22872579-8	2012	These findings suggest that l-Arg stimulation of insulin secretion in beta-cells is mediated, at least in part, through GPRC6A activation of cAMP pathways.	Arginine	28-33	G protein-coupled receptor, family C, group 6, member A	Mus musculus	120-126
22728135-3	2012	Both assays identify a cluster of lysine and arginine residues as important for myosin polymerization in vitro.	Arginine	45-53	myosin heavy chain 14	Homo sapiens	80-86
22455726-3	2012	Recently, it has been reported that PRMT6-mediated di-methylation of histone H3 at arginine 2 (H3R2me2) can antagonize tri-methylation of histone H3 at lysine 4 (H3K4me3), which marks active genes.	Arginine	83-91	protein arginine N-methyltransferase 6	Mus musculus	36-41
22980328-3	2012	Accumulated intracellular citrulline is thought to fuel arginine synthesis catalyzed by argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl), which would lead to abundant NO production.	Arginine	56-64	argininosuccinate synthase 1	Homo sapiens	88-114
17900569-1	2007	Argininosuccinate-synthetase (ASS), argininosuccinate-lyase (ASL) and nitric oxide synthase (NOS) act in the l-arginine-NO-l-citrulline cycle.	Arginine	109-119	argininosuccinate lyase	Rattus norvegicus	36-59
17900569-1	2007	Argininosuccinate-synthetase (ASS), argininosuccinate-lyase (ASL) and nitric oxide synthase (NOS) act in the l-arginine-NO-l-citrulline cycle.	Arginine	109-119	argininosuccinate lyase	Rattus norvegicus	61-64
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Arginine	132-135	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	40-43
17932487-7	2007	Mutations of a conserved arginine residue in the N-terminus of tau, found in patients with FTDP-17, affect its binding to dynactin, which is abnormally distributed in the retinal ganglion cell axons of transgenic mice expressing human tau with a mutation in the microtubule-binding domain.	Arginine	25-33	microtubule associated protein tau	Homo sapiens	91-98
17947579-4	2007	We demonstrate that the Jumonji domain-containing 6 protein (JMJD6) is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays.	Arginine	168-176	jumonji domain containing 6	Mus musculus	61-66
22980328-3	2012	Accumulated intracellular citrulline is thought to fuel arginine synthesis catalyzed by argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl), which would lead to abundant NO production.	Arginine	56-64	argininosuccinate synthase 1	Homo sapiens	116-120
22980328-5	2012	Later, extracellular arginine is depleted, and Ass1 expression allows macrophages to synthesize arginine from imported citrulline to sustain NO output.	Arginine	96-104	argininosuccinate synthase 1	Homo sapiens	47-51
22980328-6	2012	Ass1-deficient macrophages fail to salvage citrulline in arginine-scarce conditions, leading to their inability to control mycobacteria infection.	Arginine	57-65	argininosuccinate synthase 1	Homo sapiens	0-4
22759779-0	2012	Arg(972) insulin receptor substrate-1 is associated with elevated plasma endothelin-1 level in hypertensives.	Arginine	0-3	insulin receptor substrate 1	Homo sapiens	9-37
22759779-1	2012	OBJECTIVES: To explore the association among Arg(972) insulin receptor substrate-1 (IRS-1), hypertension, insulin resistance, and plasma levels of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1).	Arginine	45-48	insulin receptor substrate 1	Homo sapiens	54-82
22759779-1	2012	OBJECTIVES: To explore the association among Arg(972) insulin receptor substrate-1 (IRS-1), hypertension, insulin resistance, and plasma levels of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1).	Arginine	45-48	insulin receptor substrate 1	Homo sapiens	84-89
22759779-5	2012	RESULTS: There was no significant difference in allelic frequency between patients with and without primary hypertension or insulin resistance, in the hypertensives, heterozygous Arg(972) IRS-1 carriers had significantly higher plasma ET-1 levels and blood pressure (BP) than the homozygous carriers.	Arginine	179-182	insulin receptor substrate 1	Homo sapiens	188-193
22759779-6	2012	Although shear stress decreased ET-1 expression in control HUVECs as well as cells transfected with wild type Arg(972) IRS-1, it increased the mRNA dose-dependently and secreted protein levels of ET-1 in cells transfected with Arg(972) IRS-1.	Arginine	110-113	insulin receptor substrate 1	Homo sapiens	119-124
22759779-7	2012	CONCLUSIONS: Based on both in-vivo and in-vitro data, we have shown a potential causal association between Arg(972) IRS-1 and elevated plasma ET-1 level in hypertensives, which may account for the aggravated hypertension observed in hypertensives with heterozygous Arg(972) IRS-1.	Arginine	107-110	insulin receptor substrate 1	Homo sapiens	116-121
22137265-8	2012	Addition of 100 and 350 muM Arg to culture medium dose-dependently increased (a) protein synthesis and decreased protein degradation and (b) the abundance of total and phosphorylated mTOR, p70S6K and 4EBP1 proteins.	Arginine	28-31	ribosomal protein S6 kinase B1	Homo sapiens	189-205
17572636-4	2007	In both the wild-type ACVR1 model and template crystal structures (TbetaRI), the conserved arginine appears to form a salt bridge with an invariant aspartate residue.	Arginine	91-99	transforming growth factor beta receptor 1	Homo sapiens	67-74
22869748-2	2012	Interestingly, the Gly(717)-to-Arg mutation partially compensates the eEF2 functional loss resulting from diphthamide deficiency, possibly because the added +1 charge compensates for the loss of the +1 charge on diphthamide.	Arginine	31-34	eukaryotic translation elongation factor 2	Mus musculus	70-74
17721439-5	2007	An intricate web of interactions is observed between the CCT domain and an Arg-Phe-Xaa-Val motif-containing peptide derived from WNK4.	Arginine	75-78	WNK lysine deficient protein kinase 4	Homo sapiens	129-133
22665483-5	2012	In this investigation, we demonstrate that arginine 3765 of the MLL1 Win motif is required to co-immunoprecipitate WRAD from mammalian cells, suggesting that the WDR5-Win motif interaction is important for the assembly of the MLL1 core complex in vivo.	Arginine	43-51	lysine methyltransferase 2A	Homo sapiens	64-68
17631664-4	2007	An important common feature shared by galectin-1 and -3 was that the arginines formed in-plane ion pairs with two side-chain carboxylates, which resulted in extended planar pi-electron surfaces that did not require solvation by water; these surfaces were ideal for stacking with aromatic moieties of the ligands.	Arginine	69-78	galectin 1	Homo sapiens	38-55
17683385-4	2007	Following direct sequencing, we found a single nucleotide substitution in one allele at the residue position 466 of the 1A rod domain segment (CGC to TGC, arginine to cysteine; R156C) in keratin 10.	Arginine	155-163	keratin 10	Homo sapiens	187-197
22665483-5	2012	In this investigation, we demonstrate that arginine 3765 of the MLL1 Win motif is required to co-immunoprecipitate WRAD from mammalian cells, suggesting that the WDR5-Win motif interaction is important for the assembly of the MLL1 core complex in vivo.	Arginine	43-51	lysine methyltransferase 2A	Homo sapiens	226-230
22700724-5	2012	Whereas IgG reduced this binding significantly, the Arg residues (162-163) of the C1q-A chain, which are thought to contribute to the C1q-IgG interaction, were not required for C1q binding to DC-SIGN.	Arginine	52-55	complement C1q A chain	Homo sapiens	82-87
22700724-5	2012	Whereas IgG reduced this binding significantly, the Arg residues (162-163) of the C1q-A chain, which are thought to contribute to the C1q-IgG interaction, were not required for C1q binding to DC-SIGN.	Arginine	52-55	complement C1q A chain	Homo sapiens	82-85
17470644-5	2007	Likewise, in animals pretreated with Epo, L-arginine but not D-arginine given postinjury increased brain tissue NO concentrations and increased CBF.	Arginine	42-52	erythropoietin	Rattus norvegicus	37-40
22697391-3	2012	The Nuclear poly(A) binding protein 1 (PABPN1) is methylated by PRMT1 at 13 arginine residues located in RXR sequences in the protein"s C-terminal domain.	Arginine	76-84	poly(A) binding protein nuclear 1	Homo sapiens	39-45
22447520-6	2012	Interestingly, we also discovered two unreported sequence variants in SPINT1 and SPINT2 in two tumors that resulted in Arginine to Histidine amino acid substitutions at codons 418 and 233, respectively.	Arginine	119-127	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	81-87
17219431-6	2007	mK1 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Arginine	59-62	keratin 1	Mus musculus	0-3
22396072-1	2012	Isocitrate dehydrogenase 1 (IDH1) mutations, which are early and frequent genetic alterations in astrocytomas, oligodendrogliomas, oligoastrocytomas, and secondary glioblastomas, are specific to arginine 132 (R132).	Arginine	195-203	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
17493940-5	2007	The amino acid residues responsible for Smad6 sensitivity of ALK-3 were identified as Arg-238, Phe-264, Thr-265, and Ala-269, which map to the N-terminal lobe of the ALK-3 kinase domain.	Arginine	86-89	SMAD family member 6	Homo sapiens	40-45
22396072-1	2012	Isocitrate dehydrogenase 1 (IDH1) mutations, which are early and frequent genetic alterations in astrocytomas, oligodendrogliomas, oligoastrocytomas, and secondary glioblastomas, are specific to arginine 132 (R132).	Arginine	195-203	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
22625178-3	2012	Here we describe an approach to turning on CPP function by modulation of the local density of arginine (Arg) residues by temperature-triggered micelle assembly of diblock copolymer elastin-like polypeptides (ELP(BC)s).	Arginine	94-102	nuclear receptor subfamily 5 group A member 1	Homo sapiens	208-211
17620730-1	2007	The product of the human major histocompatibility (HLA) class I allele HLA-B*1402 only differs from that of allele HLA-B*1403 at amino-acid position 156 of the heavy chain (Leu in HLA-B*1402 and Arg in HLA-B*1403).	Arginine	195-198	major histocompatibility complex, class I, B	Homo sapiens	71-76
17620730-4	2007	The products of these alleles can present peptides with Arg at position 2, a feature shared by a small group of other HLA-B antigens, including HLA-B*2705, the prototypical AS-associated subtype.	Arginine	56-59	major histocompatibility complex, class I, B	Homo sapiens	118-123
22625178-3	2012	Here we describe an approach to turning on CPP function by modulation of the local density of arginine (Arg) residues by temperature-triggered micelle assembly of diblock copolymer elastin-like polypeptides (ELP(BC)s).	Arginine	104-107	nuclear receptor subfamily 5 group A member 1	Homo sapiens	208-211
22625178-4	2012	A greater than 8-fold increase in cellular uptake occurs when Arg residues are presented on the corona of ELP(BC) micelles, as compared to the same ELP(BC) at a temperature in which it is a soluble unimer.	Arginine	62-65	nuclear receptor subfamily 5 group A member 1	Homo sapiens	106-109
22237417-4	2012	We expressed both MST1 gene variants (Arg(689) (MSP(wt)) and Cys(689) (MSP(mut)) in a eukaryotic cell system and compared their stimulatory effects on macrophage-like THP-1 cells.	Arginine	38-41	macrophage stimulating 1	Homo sapiens	18-22
17506542-3	2007	All presently known phosphorylation sites for RhoGDI-1 lie within the 10 residues immediately prior to the 3 sites for arginine dimethylation, and these dimethylation/phosphorylation modules may constitute functional switches.	Arginine	119-127	Rho GDP dissociation inhibitor alpha	Rattus norvegicus	46-54
22457348-9	2012	Two amino acids (lysine 715 and arginine 716) of the TRPC4 C terminus were identified by structural modeling as mediating the interaction with Galpha(i2).	Arginine	32-40	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	143-152
22387109-4	2012	There were significant differences in L-arginine, L-citrulline, L-ornithine, agmatine, putrescine, spermidine, spermine, and glutamate, but not GABA, in the CA1, CA2/3, and dentate gyrus sub-regions of the hippocampus and the prefrontal, entorhinal, perirhinal, and postrhinal cortices in 24 (aged) and 4 (young) months old rats in a region-specific manner.	Arginine	38-48	carbonic anhydrase 1	Rattus norvegicus	157-160
17473281-9	2007	Our results indicated that LGR8 Asp-227 was crucial for binding INSL3 Arg-B16, whereas LGR8 Phe-131 and Gln-133 were involved in INSL3 Trp-B27 binding.	Arginine	70-73	relaxin family peptide receptor 2	Homo sapiens	27-31
17559587-2	2007	This allele is identical to the HLA-B*3503 allele except for one point mutation in exon 4 at codon 188 (CAC--&gt;CGC), resulting in an amino acid change from histidine to arginine.	Arginine	171-179	major histocompatibility complex, class I, B	Homo sapiens	32-37
22774401-1	2012	BACKGROUND: The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C-&gt;T) on insulin resistance in obese patients.	Arginine	85-93	adrenoceptor beta 3	Homo sapiens	130-150
17477906-3	2007	A mutant p21(Cip1) in which all six lysines were changed to arginines was protected against H(2)O(2) treatment.	Arginine	60-69	H3 histone pseudogene 16	Homo sapiens	9-12
22774401-1	2012	BACKGROUND: The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C-&gt;T) on insulin resistance in obese patients.	Arginine	85-93	adrenoceptor beta 3	Homo sapiens	152-159
21642764-9	2012	At each time point ARG-induced insulin increase was coupled to increase in glucagon and IGFBP-1 levels.	Arginine	19-22	insulin like growth factor binding protein 1	Homo sapiens	88-95
17320923-4	2007	Furthermore, we observed that deletion or substitution of arginine at position 59 (Arg(59)) within the CD4 peptide sequence abrogated its gp120-shedding property.	Arginine	58-66	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
17320923-4	2007	Furthermore, we observed that deletion or substitution of arginine at position 59 (Arg(59)) within the CD4 peptide sequence abrogated its gp120-shedding property.	Arginine	83-86	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
17449872-3	2007	By introducing point mutations into a subdomain interface at the base of the myosin lever arm at positions Lys(84) and Arg(704), we caused modulatory changes in the equilibrium constant of the recovery stroke, which we could accurately resolve using the fluorescence signal of single tryptophan Dictyostelium myosin II constructs.	Arginine	119-122	myosin heavy chain 14	Homo sapiens	77-83
21642764-11	2012	Our findings also show that ARG stimulates IGFBP-1 despite marked increase in insulin secretion; this escape from the negative relationship linking insulin and IGFBP- 1 would likely reflect the ARG-induced glucagon increase.	Arginine	28-31	insulin like growth factor binding protein 1	Homo sapiens	43-50
17449872-3	2007	By introducing point mutations into a subdomain interface at the base of the myosin lever arm at positions Lys(84) and Arg(704), we caused modulatory changes in the equilibrium constant of the recovery stroke, which we could accurately resolve using the fluorescence signal of single tryptophan Dictyostelium myosin II constructs.	Arginine	119-122	myosin heavy chain 14	Homo sapiens	309-315
22312127-5	2012	Mutant Foxp3 proteins carrying arginine substitutions at the three acetylation sites (3KR) accumulate in T cells to higher levels than wild-type Foxp3 and exert better suppressive activity in coculture experiments.	Arginine	31-39	forkhead box P3	Mus musculus	7-12
17416668-2	2007	The AruH protein was proposed to catalyze the first step in the ATA pathway, converting the substrates L-arginine and pyruvate into 2-ketoarginine and L-alanine.	Arginine	103-113	arginine:pyruvate transaminase AruH	Pseudomonas aeruginosa PAO1	4-8
17416668-7	2007	The optimal activity of AruH was found at pH 9.0, and it has a novel substrate specificity with an order of preference of Arg &gt; Lys &gt; Met &gt; Leu &gt; Orn &gt; Gln.	Arginine	122-125	arginine:pyruvate transaminase AruH	Pseudomonas aeruginosa PAO1	24-28
17416668-7	2007	The optimal activity of AruH was found at pH 9.0, and it has a novel substrate specificity with an order of preference of Arg &gt; Lys &gt; Met &gt; Leu &gt; Orn &gt; Gln.	Arginine	122-125	oligoribonuclease	Pseudomonas aeruginosa PAO1	158-161
22306016-5	2012	To decrease this potentially lethal effect, we generated and tested a modified form that contains a single arginine to glutamate mutation at the 76th position (EPO-R76E).	Arginine	107-115	erythropoietin	Mus musculus	160-163
17327486-1	2007	The kinins, bradykinin (BK) and Lys-des[Arg(9)]-BK, are important inflammatory mediators that act via two specific G protein-coupled kinins, B(1) and B(2) receptors (B(2)R).	Arginine	40-43	bradykinin receptor B2	Homo sapiens	150-171
22230225-8	2012	Based on the recent reports on the nutritional therapies of arginine supplementation for wound healing and for cardiovascular diseases, the higher level of arginine in the lactoferrin protein of Vechur cow milk provides enormous scope for further therapeutic studies.	Arginine	156-164	lactotransferrin	Bos taurus	172-183
17403028-8	2007	Two alternatively spliced RBM3 isoforms that differed by a single arginine residue were identified in neurons; both were post-translationally modified.	Arginine	66-74	RNA binding motif protein 3	Homo sapiens	26-30
22021003-5	2012	Deletion analyses of Zranb2 indicated that the serine/arginine-rich (SR) domain and the glutamine-rich domain were required for the inhibition of BMP activity and the interaction with Smad1, respectively.	Arginine	54-62	bone morphogenetic protein 1	Homo sapiens	146-149
17418092-3	2007	Accordingly, Cav-3 expression was further increased during hypertrophy of L6C5 myoblasts treated with Arg(8)-vasopressin and in hypertrophic muscles of MLC/mIGF-1 transgenic mice.	Arginine	102-105	caveolin 3	Mus musculus	13-18
22291079-5	2012	Missense mutations affecting arginine codon 882 (R882-DNMT3A) were more common (n = 92; 62%) than those affecting other codons (non-R882-DNMT3A).	Arginine	29-37	DNA methyltransferase 3 alpha	Homo sapiens	54-60
17940985-1	2007	INTRODUCTION: Some studies indicate, that the Trp(64)/Arg(64) polymorphism of beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.	Arginine	54-57	adrenoceptor beta 3	Homo sapiens	78-105
17940985-1	2007	INTRODUCTION: Some studies indicate, that the Trp(64)/Arg(64) polymorphism of beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.	Arginine	54-57	adrenoceptor beta 3	Homo sapiens	107-112
17940985-13	2007	The Trp(64)/Arg(64) polymorphism of beta(3)-adrenergic receptor could be associated with lipid profile disorders observed in metabolic syndrome in postmenopausal women, however it should be explained basing on the study with more included subjects.	Arginine	12-15	adrenoceptor beta 3	Homo sapiens	36-63
21681779-6	2012	In addition, a panel of GPRC6A ligands, including calcium, OC, and arginine, exhibited in prostate cancer cell lines a dose-dependent stimulation of ERK activity, cell proliferation, chemotaxis, and prostate specific antigen and Runx2 gene expression.	Arginine	67-75	G protein-coupled receptor, family C, group 6, member A	Mus musculus	24-30
17485263-6	2007	Intriguingly, SHIP-/- peritoneal and alveolar macrophages produce less nitric oxide (NO) than wild-type macrophages because they have constitutively high arginase I levels and this enzyme competes with inducible nitric oxide synthase (iNOS) for the substrate L-arginine.	Arginine	259-269	inositol polyphosphate-5-phosphatase D	Mus musculus	14-18
17212359-8	2007	The return of Lys-Ser-Arg of the AT1R to this hybrid led to almost full recovery of Galphai and Galphaq activation.	Arginine	22-25	G protein subunit alpha q	Homo sapiens	96-103
21681779-6	2012	In addition, a panel of GPRC6A ligands, including calcium, OC, and arginine, exhibited in prostate cancer cell lines a dose-dependent stimulation of ERK activity, cell proliferation, chemotaxis, and prostate specific antigen and Runx2 gene expression.	Arginine	67-75	runt related transcription factor 2	Mus musculus	229-234
22184126-9	2012	Replacing two polybasic region residues, Arg(82) and Arg(93), eliminates the ability of a full-length, catalytically inactive enzyme (PST H331K) to compete with SW2 cell ST8SiaIV/PST and block NCAM polysialylation.	Arginine	41-44	neural cell adhesion molecule 1	Homo sapiens	193-197
22334079-3	2012	Here we show in vivo and in vitro citrullination of the arginine 3 residue of histone H4 (cit-H4R3) in response to DNA damage through the p53-PADI4 pathway.	Arginine	56-64	transformation related protein 53, pseudogene	Mus musculus	138-141
17476189-4	2007	RESULTS: Subjects with the Arg64 beta3-AR gene (Arg+) polymorphism showed significantly higher fasting (FTG) and postprandial (PTG) triglyceride levels, fasting plasma glucose (FPG), fasting plasma immuno-reactive insulin (FIRI) and HOMA-R in comparison with Trp64 homozygotes.	Arginine	27-30	adrenoceptor beta 3	Homo sapiens	33-41
17479195-6	2007	Exogenous ADMA significantly enhanced the increase in both TF mRNA level and activity induced by LPS, whereas L-arginine, the NOS substrate, markedly attenuated the LPS-induced TF increment.	Arginine	110-120	coagulation factor III, tissue factor	Homo sapiens	177-179
22334079-3	2012	Here we show in vivo and in vitro citrullination of the arginine 3 residue of histone H4 (cit-H4R3) in response to DNA damage through the p53-PADI4 pathway.	Arginine	56-64	peptidyl arginine deiminase, type IV	Mus musculus	142-147
22179617-1	2012	Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the alpha(V)beta(3)-integrin.	Arginine	103-106	secreted phosphoprotein 1	Homo sapiens	0-11
17382209-7	2007	L-Arginine increased and L-NAME decreased the severity of cell death caused by LPS and AR inhibitors prevented it.	Arginine	0-10	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	87-89
22179617-1	2012	Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the alpha(V)beta(3)-integrin.	Arginine	103-106	secreted phosphoprotein 1	Homo sapiens	13-16
22056783-0	2012	Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo.	Arginine	12-20	mechanistic target of rapamycin kinase	Mus musculus	59-63
17303166-1	2007	Peptidylarginine deiminase (PAD) enzymes catalyze the conversion of arginine residues in proteins to citrulline residues.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
17303166-5	2007	It has been suggested that citrullination and methylation of arginine residues are competing processes and that PAD enzymes might "reverse" the methylation of arginine residues by converting monomethylated arginine into citrulline.	Arginine	61-69	peptidyl arginine deiminase 4	Homo sapiens	112-115
23317245-6	2012	patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)=1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)=0.66(0.36-0.95)].	Arginine	275-278	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	18-21
17303166-5	2007	It has been suggested that citrullination and methylation of arginine residues are competing processes and that PAD enzymes might "reverse" the methylation of arginine residues by converting monomethylated arginine into citrulline.	Arginine	159-167	peptidyl arginine deiminase 4	Homo sapiens	112-115
17303166-5	2007	It has been suggested that citrullination and methylation of arginine residues are competing processes and that PAD enzymes might "reverse" the methylation of arginine residues by converting monomethylated arginine into citrulline.	Arginine	159-167	peptidyl arginine deiminase 4	Homo sapiens	112-115
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	45-53	peptidyl arginine deiminase 4	Homo sapiens	125-129
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	45-53	peptidyl arginine deiminase 4	Homo sapiens	110-113
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	68-76	peptidyl arginine deiminase 4	Homo sapiens	125-129
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	68-76	peptidyl arginine deiminase 4	Homo sapiens	110-113
23317245-6	2012	patients with the XPD 751 Gln/Gln genotype had significantly higher rates of response to chemotherapy [OR (95% CI)=1.54(0.87-2.65)] and those with the XRCC1 399 Gln/Gln genotype had a longer average survival time and significantly lower risk of death than did those with the Arg/Arg genotype [HR (95% CI)=0.66(0.36-0.95)].	Arginine	279-282	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	18-21
21872658-2	2012	In adipocytes, activated PKCepsilon (Protein kinase C epsilon) phosphorylates nuclear RIP140 which is then subsequently arginine methylated and exported to the cytoplasm.	Arginine	120-128	protein kinase C epsilon	Homo sapiens	25-35
21872658-2	2012	In adipocytes, activated PKCepsilon (Protein kinase C epsilon) phosphorylates nuclear RIP140 which is then subsequently arginine methylated and exported to the cytoplasm.	Arginine	120-128	protein kinase C epsilon	Homo sapiens	37-61
22550477-7	2012	CONCLUSIONS: The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.	Arginine	60-63	adrenoceptor beta 3	Homo sapiens	40-45
17330821-6	2007	Arginase-mediated L-arginine depletion induces down-regulation of CD3 zeta, the main signalling chain of the TCR, and functional T cell hyporesponsiveness.	Arginine	18-28	CD247 molecule	Homo sapiens	66-74
17330821-7	2007	Importantly, this arginase-mediated T cell suppression was reversible, as inhibition of arginase activity or addition of exogenous L-arginine restored CD3 zeta chain expression and T cell proliferation.	Arginine	131-141	CD247 molecule	Homo sapiens	151-159
17192262-6	2007	In vitro analysis showed that Arg-35 and Phe-46 of Atg16 are crucial for the interaction.	Arginine	30-33	Atg16p	Saccharomyces cerevisiae S288C	51-56
17245368-8	2007	KEY RESULTS: Using our novel assay, we demonstrate that the basic L-alpha-amino acids ornithine, lysine, and arginine are the most potent agonists at wild-type mouse GPRC6A.	Arginine	109-117	G protein-coupled receptor, family C, group 6, member A	Mus musculus	166-172
17198704-2	2007	Argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and nNOS act in the L-arginine-NO-L-citrulline cycle permitting a correct NO production.	Arginine	86-96	argininosuccinate lyase	Rattus norvegicus	36-59
17458594-15	2007	Administration of L-arginine and aprotinin led to suppression of the release of TNF-alpha, IL-1, and IL-6 during reperfusion in a statistically significant manner (all p &lt; 0.05).	Arginine	18-28	interleukin 1 alpha	Homo sapiens	91-95
17210687-4	2007	This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine.	Arginine	162-170	zinc finger CCCH-type containing 12D	Homo sapiens	30-37
17210687-4	2007	This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or dJ281H8.1, carries an A/G nonsynonymous SNP at codon 106, which alters the amino acid from lysine to arginine.	Arginine	162-170	zinc finger CCCH-type containing 12D	Homo sapiens	39-46
18605227-1	2007	We examined whether the vasodepressor effect of intermedin/adrenomedullin-2, a new member of the calcitonin gene-related peptide family, acted via activation of the nitric oxide/L-arginine pathway, the prostanoid pathway, or the opening of K+ channels.	Arginine	178-188	adrenomedullin 2	Rattus norvegicus	48-58
18605227-1	2007	We examined whether the vasodepressor effect of intermedin/adrenomedullin-2, a new member of the calcitonin gene-related peptide family, acted via activation of the nitric oxide/L-arginine pathway, the prostanoid pathway, or the opening of K+ channels.	Arginine	178-188	adrenomedullin 2	Rattus norvegicus	59-75
18605227-9	2007	Therefore, the depressor effect of intermedin/adrenomedullin-2 is not mediated via the nitric oxide/L-arginine pathway, production of prostanoids or opening of TEA-sensitive K+ channels, but is opposed by activity of the sympathetic nervous system.	Arginine	100-110	adrenomedullin 2	Rattus norvegicus	35-45
17015450-3	2006	The human PEPCK crystal structure suggests that Asp(78) influences Tyr(220); Tyr(220) helps to position bound PEP, and Glu(83) interacts with Arg(81).	Arginine	142-145	progestagen associated endometrial protein	Homo sapiens	10-13
17015450-4	2006	Experimental data on other PEPCKs indicate that Arg(81) binds PEP, and the phosphate of PEP interacts with Mn(2+) of metal site 1 for catalysis.	Arginine	48-51	progestagen associated endometrial protein	Homo sapiens	27-30
17015450-4	2006	Experimental data on other PEPCKs indicate that Arg(81) binds PEP, and the phosphate of PEP interacts with Mn(2+) of metal site 1 for catalysis.	Arginine	48-51	progestagen associated endometrial protein	Homo sapiens	62-65
17015450-16	2006	In E83A the loss of Glu(83)-Arg(81) interaction affected Arg(81)-PEP association.	Arginine	28-31	progestagen associated endometrial protein	Homo sapiens	65-68
17015450-16	2006	In E83A the loss of Glu(83)-Arg(81) interaction affected Arg(81)-PEP association.	Arginine	57-60	progestagen associated endometrial protein	Homo sapiens	65-68
17015450-20	2006	It is likely that Asp(75) substitutions affected PEP-Mn(2+) interaction by changing the positions of Asp(78), Arg(81), and Glu(83), which translated to differential effects on two directions.	Arginine	110-113	progestagen associated endometrial protein	Homo sapiens	49-52
17118358-4	2006	Using mass-spectrometric analysis, we found that PRMT1 dimethylates arginine(74) (Arg(74)) in mouse Smad6.	Arginine	68-76	protein arginine N-methyltransferase 1	Mus musculus	49-54
17118358-4	2006	Using mass-spectrometric analysis, we found that PRMT1 dimethylates arginine(74) (Arg(74)) in mouse Smad6.	Arginine	68-76	SMAD family member 6	Mus musculus	100-105
17118358-4	2006	Using mass-spectrometric analysis, we found that PRMT1 dimethylates arginine(74) (Arg(74)) in mouse Smad6.	Arginine	82-85	protein arginine N-methyltransferase 1	Mus musculus	49-54
17118358-4	2006	Using mass-spectrometric analysis, we found that PRMT1 dimethylates arginine(74) (Arg(74)) in mouse Smad6.	Arginine	82-85	SMAD family member 6	Mus musculus	100-105
17118358-5	2006	PRMT1 interacts with the N-terminal domain of Smad6 in which Arg(74) residue is located.	Arginine	61-64	protein arginine N-methyltransferase 1	Mus musculus	0-5
17118358-5	2006	PRMT1 interacts with the N-terminal domain of Smad6 in which Arg(74) residue is located.	Arginine	61-64	SMAD family member 6	Mus musculus	46-51
16987810-4	2006	CKIP-1 mutants harboring Arg-155 and Arg-157 substitutions exhibited greatly decreased CP binding, while retaining wild-type localization, the ability to interact with protein kinase CK2, and self-association.	Arginine	25-28	pleckstrin homology domain containing O1	Homo sapiens	0-6
16987810-4	2006	CKIP-1 mutants harboring Arg-155 and Arg-157 substitutions exhibited greatly decreased CP binding, while retaining wild-type localization, the ability to interact with protein kinase CK2, and self-association.	Arginine	37-40	pleckstrin homology domain containing O1	Homo sapiens	0-6
17010310-2	2006	Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three RNA recognition motifs, and an Arg/Gly-rich region.	Arginine	182-185	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	65-71
16997281-2	2006	In this study we produced, and expressed in Xenopus oocytes, individual alanine point mutants of positively charged amino acids (eight lysine, seven arginine and one histidine) in the intracellular domains of the human P2X1 receptor.	Arginine	149-157	purinergic receptor P2X 1	Homo sapiens	219-232
17075427-5	2006	The heterozygous, Gly/Arg variant of the IRS-1 gene was overrepresented and the homozygous, Gly/Gly variant was less frequent in male patients compared with male controls.	Arginine	22-25	insulin receptor substrate 1	Homo sapiens	41-46
17075427-9	2006	CONCLUSION: The polymorphism of the IRS-1 gene at codon 972, especially Gly/Arg variant, or the presence of the allele for Arg appears to be associated with occurrence of OSAS in male patients, whereas this polymorphism is not related to severity of OSAS.	Arginine	76-79	insulin receptor substrate 1	Homo sapiens	36-41
17040296-6	2006	Further, the tumor cells had intense nuclear accumulation of beta-catenin and an activating mutation, (34)Gly(GGA) to Arg(AGA), in exon 3 of the beta-catenin gene, as previously reported in most SPT.	Arginine	118-121	catenin beta 1	Homo sapiens	145-157
16927306-3	2006	Ehm2 is an androgen-regulated gene that has been associated with metastasis in other systems, so we sought to determine if it is expressed in prostate cancer and if the FGFR-4 Arg(388) variant can increase its expression.	Arginine	176-179	erythrocyte membrane protein band 4.1 like 4B	Homo sapiens	0-4
16927306-7	2006	Expression of the FGFR-4 Arg(388) variant results in increased expression of Ehm2.	Arginine	25-28	erythrocyte membrane protein band 4.1 like 4B	Homo sapiens	77-81
17024283-3	2006	One type of MHC molecule, HLA-B*2705, preferentially binds peptides containing an arginine at position 2.	Arginine	82-90	major histocompatibility complex, class I, B	Homo sapiens	26-31
16622593-3	2006	A new PRNP polymorphism encoding either glycine (G) or arginine (R) at codon 85 as well as eight previously reported polymorphisms at codons 101, 112, 127, 141, 146, 154, 171, and 189 in other sheep breeds were detected.	Arginine	55-63	major prion protein	Ovis aries	6-10
16794254-4	2006	In this report, we investigated the effect of a cysteine-to-arginine mutation (C417R) found in the NEMO zinc finger domain on dendritic cell (DC) function.	Arginine	60-68	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	99-103
17012248-10	2006	The "essential arginine" critical for sialic acid recognition in both Siglec-14 and Siglec-5 is present in humans but mutated in almost all great ape alleles.	Arginine	15-23	sialic acid binding Ig like lectin 5	Homo sapiens	84-92
22550477-7	2012	CONCLUSIONS: The level of LDL, age, and ADRB3 polymorphism (Arg/Arg genotype) were statistically associated with annual BMI gain in Japanese men.	Arginine	64-67	adrenoceptor beta 3	Homo sapiens	40-45
22113295-2	2012	One of the histone modifications, histone citrullination, is catalyzed by an enzyme called peptidylarginine deiminase 4 (PAD4, also called PADI4), which converts both histone arginine (Arg) and mono-methyl arginine residues to citrulline.	Arginine	185-188	peptidyl arginine deiminase 4	Homo sapiens	91-119
16982895-6	2006	A central cluster of hydrophilic CD1d residues (Asp(153), Thr(156), Ser(76), Arg(79)) interacts with the phosphate, inositol, and alpha1-alpha6-linked mannose of the headgroup, whereas additional specificity for the alpha1- and alpha2-linked mannose is conferred by Thr(159).	Arginine	77-80	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	130-143
16981702-1	2006	Aminopeptidase B (EC 3.4.11.6, ApB) specifically cleaves in vitro the N-terminal Arg or Lys residue from peptides and synthetic derivatives.	Arginine	81-84	arginyl aminopeptidase	Rattus norvegicus	0-16
22113295-2	2012	One of the histone modifications, histone citrullination, is catalyzed by an enzyme called peptidylarginine deiminase 4 (PAD4, also called PADI4), which converts both histone arginine (Arg) and mono-methyl arginine residues to citrulline.	Arginine	185-188	peptidyl arginine deiminase 4	Homo sapiens	121-125
21893093-1	2012	Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme arginine decarboxylase.	Arginine	64-74	antizyme inhibitor 2	Homo sapiens	89-111
16861740-7	2006	Cys-69 resides within the OPR, PC, and AID motif of PKCiota at the binding interface between PKCiota and Par6 where it interacts with Arg-28 on Par6.	Arginine	134-137	Prader Willi/Angelman region RNA 6	Homo sapiens	105-109
16861740-7	2006	Cys-69 resides within the OPR, PC, and AID motif of PKCiota at the binding interface between PKCiota and Par6 where it interacts with Arg-28 on Par6.	Arginine	134-137	Prader Willi/Angelman region RNA 6	Homo sapiens	144-148
22403718-0	2012	Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes.	Arginine	23-26	major histocompatibility complex, class I, B	Homo sapiens	83-90
16489109-3	2006	tPA-induced contraction of rat aortic rings is inhibited by the Arg-Gly-Asp (RGD) peptide and by monoclonal anti-alphavbeta3 antibody.	Arginine	64-67	plasminogen activator, tissue type	Rattus norvegicus	0-3
21835259-6	2011	Cysteine proteinase (gingipain)-deficient P. gingivalis mutants were used to demonstrate that both Arg- and Lys-gingipain activities are involved in EMMPRIN shedding.	Arginine	99-102	basigin (Ok blood group)	Homo sapiens	149-156
16709924-5	2006	This T-cell phenotype is due to arginase-mediated depletion of arginine in the T-cell environment, which leads to CD3zeta chain down-regulation but does not alter T-cell viability.	Arginine	63-71	CD247 molecule	Homo sapiens	114-127
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	197-200	8-oxoguanine DNA glycosylase	Homo sapiens	40-45
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	197-200	8-oxoguanine DNA glycosylase	Homo sapiens	170-175
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	8-oxoguanine DNA glycosylase	Homo sapiens	40-45
21969604-7	2011	Mutation of the catalytic arginine of the GAP domain of RhoGAP22 potentiated growth factor-stimulated Rac1 GTP loading.	Arginine	26-34	Rho GTPase activating protein 22	Homo sapiens	56-64
21778808-4	2011	We demonstrated that symmetric arginine dimethylation of eukaryotic elongation factor 2 (eEF2) is induced by bFGF without the change in the expression level of eEF2 in mouse embryo fibroblast NIH3T3 cells.	Arginine	31-39	eukaryotic translation elongation factor 2	Mus musculus	57-87
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	8-oxoguanine DNA glycosylase	Homo sapiens	170-175
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	8-oxoguanine DNA glycosylase	Homo sapiens	40-45
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	8-oxoguanine DNA glycosylase	Homo sapiens	170-175
21778808-4	2011	We demonstrated that symmetric arginine dimethylation of eukaryotic elongation factor 2 (eEF2) is induced by bFGF without the change in the expression level of eEF2 in mouse embryo fibroblast NIH3T3 cells.	Arginine	31-39	eukaryotic translation elongation factor 2	Mus musculus	89-93
21778808-7	2011	Collectively, we demonstrated that eEF2, a key factor involved in protein translational elongation is symmetrically arginine-methylated in a reversible manner, being regulated by bFGF through MAPK signaling pathway.	Arginine	116-124	eukaryotic translation elongation factor 2	Mus musculus	35-39
21787770-4	2011	RESULTS: L-Arg significantly increased CBF of cultured nasal and tracheal epithelial cells, and the effects were blocked by pretreatment with N(G)-nitro-l-arginine methyl ester (L-NAME), a NOS inhibitor, with LY-83583, a sGC inhibitor, or with KT-5823, a PKG inhibitor.	Arginine	9-14	serglycin	Mus musculus	221-224
16797727-9	2006	However, in monocyte-derived macrophages, with a higher NO production, aminoguanidine increased IDO activity, but the NOS substrate arginine decreased IDO activity.	Arginine	132-140	indoleamine 2,3-dioxygenase 1	Homo sapiens	151-154
21802447-6	2011	Site-directed structural modifications of aprotinin are possible to increase its intracellular targeting of cleavage of highly virulent H5 and H7 hemagglutinins possessing multi-arginine/lysine cleavage site.	Arginine	178-186	pancreatic trypsin inhibitor	Bos taurus	42-51
16889659-14	2006	Arginine-83 of yeast Vps25p involved in Vps22p interaction was highly, but not absolutely, conserved.	Arginine	0-8	ESCRT-II subunit protein VPS25	Saccharomyces cerevisiae S288C	21-27
22215963-6	2011	The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence.	Arginine	124-132	PPARG coactivator 1 alpha	Bos taurus	156-164
16724007-0	2006	Delineation of the ADULT syndrome phenotype due to arginine 298 mutations of the p63 gene.	Arginine	51-59	tumor protein p63	Homo sapiens	81-84
16877393-4	2006	RESULTS: A tetrapeptide (SSSR; Ser(33)-Ser-Ser-Arg) derived from the C domain of IGF-1 was sufficient for the synergistic promotion with FGLM-amide both of corneal epithelial migration in vitro and of wound closure in vivo.	Arginine	47-50	insulin-like growth factor I	Oryctolagus cuniculus	81-86
16782888-7	2006	Overexpressed BTG2 increases PRMT1 participation in the RARalpha protein complex on the RARbeta promoter, a target gene model, and enhances gene-specific histone H4 arginine methylation.	Arginine	165-173	BTG anti-proliferation factor 2	Homo sapiens	14-18
16782888-10	2006	Overall, our data show that BTG2 contributes to retinoic acid activity by favoring differentiation through a gene-specific modification of histone H4 arginine methylation and acetylation levels.	Arginine	150-158	BTG anti-proliferation factor 2	Homo sapiens	28-32
16734667-3	2006	The Pmp2p isoproteolipid, a type I yeast membrane protein, reports faithfully on the activity of sorting signals when fused to a tail containing either an Arg-based motif or a -KKXX signal.	Arginine	155-158	proteolipid ATPase	Saccharomyces cerevisiae S288C	4-9
16734667-6	2006	Multimeric presentation of the Arg-based signal from Kir6.2 on Pmp2p results in forward transport, which requires 14-3-3 proteins encoded in yeast by BMH1 and BMH2 in two isoforms.	Arginine	31-34	proteolipid ATPase	Saccharomyces cerevisiae S288C	63-68
16734667-6	2006	Multimeric presentation of the Arg-based signal from Kir6.2 on Pmp2p results in forward transport, which requires 14-3-3 proteins encoded in yeast by BMH1 and BMH2 in two isoforms.	Arginine	31-34	14-3-3 family protein BMH2	Saccharomyces cerevisiae S288C	159-163
16819283-3	2006	One KCNRG missense mutation, CGT CAT (Arg His) was found at codon 92 within the T1 domain.	Arginine	38-41	potassium channel regulator	Homo sapiens	4-9
16595170-4	2006	Unexpectedly, the naturally occurring mutation of Arg(3.50) to His in mouse GPR33 showed no difference from the wild-type receptor in several functional tests.	Arginine	50-53	G protein-coupled receptor 33	Mus musculus	76-81
16595170-5	2006	Sequence analysis of GPR33 from Asian house mice revealed the polymorphic existence of Arg(3.50) and His(3.50) alleles in wild-trapped populations, further supporting the functional equivalence of both allelic variants.	Arginine	87-90	G protein-coupled receptor 33	Mus musculus	21-26
16631200-0	2006	Local arginine supplementation results in sustained wound nitric oxide production and reductions in vascular endothelial growth factor expression and granulation tissue formation.	Arginine	6-14	vascular endothelial growth factor A	Sus scrofa	100-134
16631200-13	2006	Conversely, late VEGF levels (days 11 to 14) were reduced in the L-arginine animals compared to controls (7500 pg/ml versus 10,000 pg/ml at day 11, P &lt; 0.05; 7250 pg/ml versus 11,101 pg/ml at day 14, P &lt; 0.05).	Arginine	65-75	vascular endothelial growth factor A	Sus scrofa	17-21
16670299-2	2006	Th1-type cytokines induce NO synthase 2, which metabolizes arginine into nitrites, while the Th2-type cytokines produce arginase, which converts arginine into polyamines and proline.	Arginine	145-153	heart and neural crest derivatives expressed 2	Mus musculus	93-96
16670299-5	2006	Macrophages from Slc7A2 knockout mice showed a decrease in L-arginine transport in response to the two kinds of cytokines.	Arginine	59-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	17-23
16670299-7	2006	In addition, the induction of Slc7A2 expression was independent of the arginine available and of the enzymes that metabolize it.	Arginine	71-79	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	30-36
16628754-4	2006	Validation by analysis of isolated peptide substrates has revealed that neurolysin recognizes the motif hydrophobic-X-Pro-Arg-hydrophobic, where Arg-hydrophobic is the scissile bond.	Arginine	122-125	neurolysin	Homo sapiens	72-82
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	H3 histone pseudogene 16	Homo sapiens	150-153
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	H3 histone pseudogene 16	Homo sapiens	150-153
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	H3 histone pseudogene 16	Homo sapiens	150-153
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	H3 histone pseudogene 16	Homo sapiens	150-153
16697770-9	2006	Higher ORs for COPD were seen for persons with p53 Pro/Pro or Pro/Arg genotypes against Arg/Arg genotype [OR = 2.35, 95% CI 1.27-4.39, P = 0.008], or p21 Arg/Arg and Arg/Ser genotypes against Ser/Ser genotype [OR = 2.07, 95% CI 1.06-4.05, P = 0.033].	Arginine	88-91	H3 histone pseudogene 16	Homo sapiens	150-153
16337282-11	2006	The site of trypsin cleavage was identified in the deduced amino acid sequence of muB by determining the amino-terminal sequences of phi proteins: between arginine 582 and glycine 583.	Arginine	155-163	ubiquitin like 3	Homo sapiens	82-85
16623599-4	2006	In contrast, a high degree of specificity for the basic side chain could be observed because the KIR-DAP12 and FcalphaRI-Fcgamma interactions favored lysine or arginine, respectively.	Arginine	160-168	transmembrane immune signaling adaptor TYROBP	Homo sapiens	101-106
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Arginine	49-52	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	35-38
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Arginine	49-52	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	99-102
16618936-8	2006	Notably the residues essential for GGT activity (Arg-114, Asp-433, Ser-462, and Ser-463 in E. coli GGT) shown by site-directed mutagenesis of human GGT are all involved in the binding of the gamma-glutamyl moiety.	Arginine	49-52	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	99-102
16487488-0	2006	FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues.	Arginine	28-36	F-box protein 11	Homo sapiens	0-6
16715630-3	2006	ArG consist of abnormally hyperphosphorylated form of tau protein.	Arginine	0-3	microtubule associated protein tau	Homo sapiens	54-57
16773504-9	2006	Molecular genetic studies revealed a heterozygote missense mutation, MCCA-R385S, converting arginine to serine in a highly conserved region of the MCCA gene.	Arginine	92-100	methylcrotonyl-CoA carboxylase subunit 1	Homo sapiens	69-73
16773504-9	2006	Molecular genetic studies revealed a heterozygote missense mutation, MCCA-R385S, converting arginine to serine in a highly conserved region of the MCCA gene.	Arginine	92-100	methylcrotonyl-CoA carboxylase subunit 1	Homo sapiens	147-151
22232927-6	2011	In females, the frequency of unfavorable outcomes (fatal or nonfatal myocardial infarction and fatal or nonfatal stroke) was higher in carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and carriers of genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene, but the difference was not statistically significant.	Arginine	236-239	thrombomodulin	Homo sapiens	201-205
22232927-6	2011	In females, the frequency of unfavorable outcomes (fatal or nonfatal myocardial infarction and fatal or nonfatal stroke) was higher in carriers of allele Val of the Ala344Val polymorphic marker of the THBD gene and carriers of genotype Arg/Arg of the Arg353Gln polymorphic marker of the F7 gene, but the difference was not statistically significant.	Arginine	240-243	thrombomodulin	Homo sapiens	201-205
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Arginine	31-39	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	86-91
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Arginine	31-39	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	125-130
21338354-5	2011	Mutation of lysine residues to arginine residues at the glutamate receptor subunit 1 (GluA1) C-terminus dramatically reduces GluA1 ubiquitination and abolishes ubiquitin-dependent GluA1 internalization and degradation, indicating that the lysine residues, particularly K868, are sites of ubiquitination.	Arginine	31-39	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	125-130
21828056-7	2011	By comparing the apo and inhibited caspase-2 structures, we propose that the disruption of a non-conserved salt bridge between Glu-217 and the invariant Arg-378 is important for the activation of caspase-2.	Arginine	153-156	caspase 2	Homo sapiens	35-44
21828056-7	2011	By comparing the apo and inhibited caspase-2 structures, we propose that the disruption of a non-conserved salt bridge between Glu-217 and the invariant Arg-378 is important for the activation of caspase-2.	Arginine	153-156	caspase 2	Homo sapiens	196-205
21906945-8	2011	Disruption of beta1-integrin function by active Arg results in altered distribution of selected polarity complex components mediated in part by Rap1 GTPase signaling.	Arginine	48-51	RAP1A, member of RAS oncogene family	Homo sapiens	144-148
16371355-10	2006	Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine.	Arginine	198-206	acyl-CoA synthetase bubblegum family member 2	Homo sapiens	75-81
16371355-10	2006	Within a highly conserved motif known to be important for catalysis, human ACSBG2 contains a histidine residue where all other known acyl-CoA synthetases, including mouse and rat ACSBG2, contain an arginine.	Arginine	198-206	acyl-CoA synthetase bubblegum family member 2	Rattus norvegicus	179-185
16492767-4	2006	In eukaryotes, ATE1-encoded arginyl-transferases (R(D,E,C*)-transferases) conjugate Arg (R), an Nd(p) residue, to Nd(s) residues Asp (D), Glu (E), or oxidized Cys residue (C*).	Arginine	84-87	arginyltransferase 1	Homo sapiens	15-19
16259621-7	2006	In the present study, we have verified the ubiquitin-independent nature of TS proteolysis by showing that a "lysine-less" polypeptide, in which all lysine residues were replaced by arginine, is still subject to proteasome-mediated degradation.	Arginine	181-189	thymidylate synthetase	Homo sapiens	75-77
16571851-2	2006	The objective of this study was to evaluate body composition in three leptin-treated Turkish adults homozygous for a missense mutation (C--&gt;T substitution at codon 105 resulting in Arg--&gt;Trp) of Lep.	Arginine	184-187	leptin	Homo sapiens	70-76
16571851-2	2006	The objective of this study was to evaluate body composition in three leptin-treated Turkish adults homozygous for a missense mutation (C--&gt;T substitution at codon 105 resulting in Arg--&gt;Trp) of Lep.	Arginine	184-187	leptin	Homo sapiens	201-204
16525354-11	2006	The expression of lymphocyte CD11a/CD18 was significantly higher in the Arg group 6, 12, and 24 h after CLP than those of the corresponding control group and the NC group.	Arginine	72-75	integrin alpha L	Mus musculus	29-34
16525354-16	2006	In addition, Arg supplementation reduced intracellular interferon-gamma and enhanced IL-4 expression.	Arginine	13-16	interleukin 4	Mus musculus	85-89
16286459-2	2006	The metal ion dependence of ADAMTS13 activity was examined with multimeric VWF and a fluorescent peptide substrate based on Asp(1596)-Arg(1668) of the VWF A2 domain, FRETS-VWF73.	Arginine	134-137	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	28-36
21808065-5	2011	Here we report that arginine methylation weakens the affinity of PABPN1 for transportin.	Arginine	20-28	poly(A) binding protein nuclear 1	Homo sapiens	65-71
21808065-12	2011	In the nucleus, arginine methylation may favor the transition of PABPN1 to the competing ligand RNA and serve to reduce the risk of the protein being reexported to the cytoplasm by transportin.	Arginine	16-24	poly(A) binding protein nuclear 1	Homo sapiens	65-71
21726068-5	2011	We report the identification of arginine methylation as a novel post-translational modification of Na(v)1.5.	Arginine	32-40	immunoglobulin lambda variable 2-18	Homo sapiens	99-107
16282318-9	2006	The C-terminal 789 amino acids of the Arabidopsis Fip1 protein were found to contain an RNA-binding domain; this domain correlated with an intact arginine-rich region and had a marked preference for poly(G) among the four homopolymers studied.	Arginine	146-154	FH interacting protein 1	Arabidopsis thaliana	50-54
21726068-7	2011	The functional relevance of arginine methylation in Na(v)1.5 is underscored by the fact that R526H and R680H are known Na(v)1.5 mutations causing Brugada and long QT type 3 syndromes, respectively.	Arginine	28-36	immunoglobulin lambda variable 2-18	Homo sapiens	52-60
21726068-7	2011	The functional relevance of arginine methylation in Na(v)1.5 is underscored by the fact that R526H and R680H are known Na(v)1.5 mutations causing Brugada and long QT type 3 syndromes, respectively.	Arginine	28-36	immunoglobulin lambda variable 2-18	Homo sapiens	119-127
21586674-3	2011	We show here that the induction of THP-1 monocyte differentiation by PMA markedly increases the expression of SLC7A7 mRNA and of y(+)LAT1 protein and consequently, the activity of system y(+)L-mediated arginine transport.	Arginine	202-210	solute carrier family 7 member 7	Homo sapiens	110-116
16475710-3	2006	The mutant alleles of CYP2C9 were residue 144 (Arg (*1)/Cys (*2)), residue 358 (Tyr/Cys), residue 359 (Ile/Leu (*3)) and residue 417 (Gly/Asp).	Arginine	47-50	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	22-28
16319129-4	2006	We show here that Fmrp is post-translationally methylated, primarily on its arginine-glycine-glycine box.	Arginine	76-84	Fmr1	Drosophila melanogaster	18-22
16319129-5	2006	We identify the four arginines that are methylated and show that cellular Fmrp is monomethylated and asymmetrically dimethylated.	Arginine	21-30	Fmr1	Drosophila melanogaster	74-78
16319129-7	2006	Recombinant protein arginine methyl transferase 1 (PRMT1) methylates Fmrp on the same arginines in vitro as in cells.	Arginine	86-95	Fmr1	Drosophila melanogaster	69-73
21586674-3	2011	We show here that the induction of THP-1 monocyte differentiation by PMA markedly increases the expression of SLC7A7 mRNA and of y(+)LAT1 protein and consequently, the activity of system y(+)L-mediated arginine transport.	Arginine	202-210	solute carrier family 7 member 5	Homo sapiens	133-137
16319129-9	2006	Our data identify an additional mechanism, arginine methylation, for modifying Fmrp function and suggest that methylation occurs to limit or modulate RNA binding by Fmrp.	Arginine	43-51	Fmr1	Drosophila melanogaster	79-83
16319129-9	2006	Our data identify an additional mechanism, arginine methylation, for modifying Fmrp function and suggest that methylation occurs to limit or modulate RNA binding by Fmrp.	Arginine	43-51	Fmr1	Drosophila melanogaster	165-169
21586674-6	2011	SLC7A7 gene silencing causes a significant reduction of system y(+)L activity and a subsequent, marked increase of arginine and lysine cell content, thus suggesting that in macrophagic cells, system y(+)L activity is mainly directed outwardly.	Arginine	115-123	solute carrier family 7 member 7	Homo sapiens	0-6
23148181-1	2011	OBJECTIVE: This study investigated the possibility that genetic factors, such as polymorphism of K inward rectifier subunit (Kir6.2), E23K, and Arg(972) polymorphism of insulin receptor sub-strate-1 (IRS-1), may predispose patients to sulfonylurea failure.	Arginine	144-147	insulin receptor substrate 1	Homo sapiens	169-198
16154612-6	2005	], p33 can be phosphorylated in vitro at serine and threonine residues adjacent to its arginine-proline-rich RNA binding site.	Arginine	87-95	inhibitor of growth family member 1	Homo sapiens	3-6
23148181-6	2011	The frequency of the Arg(972) IRS-1 variant was 6% among patients with diabetes controlled with oral therapy and 22% among patients with secondary failure.	Arginine	21-24	insulin receptor substrate 1	Homo sapiens	30-35
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Arginine	125-133	Cbl proto-oncogene	Homo sapiens	143-146
23148181-7	2011	CONCLUSION: The E23K variant of the Kir6.2 gene and Arg(972) IRS-1 variants are associated with increased risk for secondary failure to sulfonylurea.	Arginine	52-55	insulin receptor substrate 1	Homo sapiens	61-66
21402718-3	2011	By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated to produce higher uterine LIF levels during implantation than the proline allele.	Arginine	124-132	leukemia inhibitory factor	Mus musculus	183-186
16140268-7	2005	These data demonstrate that Arg-214/215 are involved in CRM1-mediated STAT3 nuclear export and the regulation of STAT3 activity.	Arginine	28-31	exportin 1	Homo sapiens	56-60
21724836-1	2011	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	protein inhibitor of activated STAT 1	Homo sapiens	39-44
16054204-6	2005	Significant independent association was evident between the p21 arginine allele (rare allele with frequency of 0.1) at codon 31 and CaCx, compared to HPV-negative cytologically normal controls (OR(age-adjusted) = 2.01; 95% CI = 1.00-4.06; P = 0.05).	Arginine	64-72	H3 histone pseudogene 16	Homo sapiens	60-63
16054204-8	2005	The p21 arginine allele was significantly associated with CaCx in the p53 proline non-homozygous group of subjects (OR(age-adjusted) = 2.68; 95% CI: 1.21-5.91; P = 0.01), and specifically in the p53 heterozygous group (OR(age-adjusted) = 2.91; 95% CI = 1.12-7.56; P = 0.03).	Arginine	8-16	H3 histone pseudogene 16	Homo sapiens	4-7
16054204-10	2005	However, the two risk factors, p53 proline homozygosity and p21 arginine allele, although part of a common causal pathway, appear to act in a mutually exclusive manner.	Arginine	64-72	H3 histone pseudogene 16	Homo sapiens	60-63
21535387-3	2011	A single antigenic surface comprising Arg(660) , Tyr(661) and Tyr(665) that contributes to the productive binding of ADAMTS13 to unfolded von Willebrand factor is targeted by anti-spacer domain antibodies.	Arginine	38-41	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	117-125
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	23-26	peptidyl arginine deiminase 4	Homo sapiens	0-4
16002497-1	2005	This study was designed to examine whether dietary L-arginine supplementation modulates exercise-induced angiogenesis and vascular endothelial growth factor (VEGF) expression in female Wistar rats.	Arginine	51-61	vascular endothelial growth factor A	Rattus norvegicus	122-156
16002497-7	2005	Western blot analysis showed that training with L-arginine significantly increased VEGF protein expression by 1.7-fold in the left ventricle, while the increase with training alone was insignificant.	Arginine	48-58	vascular endothelial growth factor A	Rattus norvegicus	83-87
16002497-10	2005	The present results suggest that L-arginine supplementation causes additional effects on exercise-induced angiogenesis in the rat heart by promoting VEGF expression.	Arginine	33-43	vascular endothelial growth factor A	Rattus norvegicus	149-153
21584310-6	2011	PAD4 citrullinates the Arg-Gly repeat region of RPS2, which is also an established site for Arg methylation by protein arginine methyltransferase 3 (PRMT3).	Arginine	92-95	peptidyl arginine deiminase 4	Homo sapiens	0-4
21565201-12	2011	MPO was decreased significantly in the Allo and l-Arg groups during reperfusion, and allopurinol administration caused earlier and stronger effect.	Arginine	48-53	myeloperoxidase	Rattus norvegicus	0-3
16159817-11	2005	Addition of L-arginine improved myocardial perfusion in response to FGF-2 at rest (ratio 1.13, P=0.02 versus HICHOL) but not during pacing (ratio 0.94, P=NS), and was associated with increased protein levels of iNOS and eNOS.	Arginine	12-22	LOC396821	Sus scrofa	211-215
21454694-5	2011	An additional mutation that reduced the affinity of CPM for C-terminal Arg and increased the affinity for C-terminal Lys inhibited the B1R response to bradykinin (with C-terminal Arg) but generated a response to Lys(9)-bradykinin.	Arginine	71-74	carboxypeptidase M	Homo sapiens	52-55
21454715-7	2011	A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression.	Arginine	23-26	H3 histone pseudogene 16	Homo sapiens	209-212
16060666-1	2005	Protein arginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the posttranslational conversion of arginine to citrulline (Arg --&gt; Cit) in a number of proteins, including histones.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
16060666-1	2005	Protein arginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the posttranslational conversion of arginine to citrulline (Arg --&gt; Cit) in a number of proteins, including histones.	Arginine	140-143	peptidyl arginine deiminase 4	Homo sapiens	0-28
16060666-1	2005	Protein arginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the posttranslational conversion of arginine to citrulline (Arg --&gt; Cit) in a number of proteins, including histones.	Arginine	140-143	peptidyl arginine deiminase 4	Homo sapiens	30-34
16060666-4	2005	Specifically, these studies confirm that PAD4 catalyzes the hydrolytic deimination of Arg residues to produce Cit and ammonia.	Arginine	86-89	peptidyl arginine deiminase 4	Homo sapiens	41-45
16060666-10	2005	The ability of PAD4 to catalyze the deimination of methylated Arg residues has also been evaluated, and the results indicate that these compounds are poor PAD4 substrates (V/K &lt;or= 31.3 M(-)(1) s(-)(1)) in comparison to other substrates.	Arginine	62-65	peptidyl arginine deiminase 4	Homo sapiens	15-19
21335044-7	2011	Such degradation was mainly due to the activity of Arg and Lys-gingipains, as pretreatment of CS with inhibitors selective for this class of proteases abolished CS ability to degrade hBD3.	Arginine	51-54	defensin beta 103B	Homo sapiens	183-187
15929988-7	2005	Cathepsin L initially released a shorter Gln(151)-Gly(160) peptide and completed processing at Ser(145) or Gly(143) at the C terminus of the N-terminal 23-kDa TRAP subunit and at Arg(163) at the N terminus of the C-terminal 16-kDa TRAP subunit.	Arginine	179-182	cathepsin L	Rattus norvegicus	0-11
21417343-1	2011	ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL.	Arginine	20-23	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	0-4
16038634-6	2005	RESULTS: L-Arg supplementation significantly reduced exercise-induced elevations of XO and MPO activities in lung.	Arginine	9-14	myeloperoxidase	Rattus norvegicus	91-94
16038634-7	2005	L-Arg reversed the exercise-induced increase in SOD and GR activities, but increased CAT and GPX activities.	Arginine	0-5	glutathione-disulfide reductase	Rattus norvegicus	56-58
16038634-9	2005	CONCLUSION: L-Arg supplementation can prevent elevations of XO and MPO activities in the lung and favorably influence pulmonary antioxidant defense systems after exhaustive exercise.	Arginine	12-17	myeloperoxidase	Rattus norvegicus	67-70
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Arginine	90-93	fibronectin 1	Mus musculus	123-134
16029420-5	2005	Interestingly, MITF with double lysine 182/316 to arginine mutations, although displaying normal DNA binding, stability and nuclear localization, shows a substantial increase in the transcriptional stimulation of promoters containing multiple but not single MITF binding sites.	Arginine	50-58	melanocyte inducing transcription factor	Homo sapiens	15-19
16029420-6	2005	MITF containing the double lysine-to-arginine substitution also shows enhanced cooperation with Sox10 on the Dct promoter.	Arginine	37-45	melanocyte inducing transcription factor	Homo sapiens	0-4
16029420-6	2005	MITF containing the double lysine-to-arginine substitution also shows enhanced cooperation with Sox10 on the Dct promoter.	Arginine	37-45	SRY-box transcription factor 10	Homo sapiens	96-101
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	histone deacetylase 1	Mus musculus	111-116
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	118-121	interleukin 11	Homo sapiens	57-71
19565007-5	2005	A G --&gt; A single nucleotide polymorphism, which causes an arginine (R) to be replaced with histidine (H) at position 131, defines two allotypes which difer in their avidity for complexed human IgG(2) and IgG(3).	Arginine	61-69	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	207-213
15908694-3	2005	To gain further insights into the structural basis for the activation of the hLHR by activating mutations, we chose to examine a particularly strong constitutively activating mutation of this receptor, L457R, in which a leucine that is highly conserved among rhodopsin-like G protein-coupled receptors in helix 3 has been substituted with arginine.	Arginine	339-347	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	77-81
16013863-1	2005	The reactivity of arginine residues in model proteins (ubiquitin, cytochrome c, myoglobin, ribonuclease A, lysozyme) was examined using a selective tagging reaction in combination with on-line monitoring of the reaction progress by electrospray ionization mass spectrometry (ESI-MS).	Arginine	18-26	myoglobin	Homo sapiens	80-89
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	118-121	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	122-125	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	122-125	interleukin 11	Homo sapiens	73-78
21148409-9	2011	Furthermore, AQP2-S261A and AQP2-S261D localized to vesicles, which was due to their increased ubiquitination, because changing K270 into Arg in both mutants resulted in their localization in the apical membrane.	Arginine	138-141	aquaporin 2	Canis lupus familiaris	13-17
16013863-3	2005	The method allows one to differentiate between different protein conformations as shown for myoglobin and its apo form and native and reduced ribonuclease A: Removal of the heme group in myoglobin resulted in an increased reactivity for the two partially buried arginines.	Arginine	262-271	myoglobin	Homo sapiens	92-101
16013863-3	2005	The method allows one to differentiate between different protein conformations as shown for myoglobin and its apo form and native and reduced ribonuclease A: Removal of the heme group in myoglobin resulted in an increased reactivity for the two partially buried arginines.	Arginine	262-271	myoglobin	Homo sapiens	187-196
21148409-9	2011	Furthermore, AQP2-S261A and AQP2-S261D localized to vesicles, which was due to their increased ubiquitination, because changing K270 into Arg in both mutants resulted in their localization in the apical membrane.	Arginine	138-141	aquaporin 2	Canis lupus familiaris	28-32
15962011-5	2005	The CIN85 SH3 domains A and C bind specifically to proline-arginine motifs present in Sprouty2.	Arginine	59-67	sprouty RTK signaling antagonist 2	Rattus norvegicus	86-94
21123835-3	2011	Furthermore, prior research suggests that TP53 mutations preferentially occur on the arginine allele to selectively inactivate the p63 pathway.	Arginine	85-93	tumor protein p63	Homo sapiens	131-134
21087206-0	2011	L-arginine promotes DNA repair in cultured bronchial epithelial cells exposed to ozone: involvement of the ATM pathway.	Arginine	0-10	ATM serine/threonine kinase	Homo sapiens	107-110
15851478-1	2005	Argininosuccinate synthase (AS) catalyzes the rate-limiting step in the recycling of citrulline to arginine, which in endothelial cells, is tightly coupled to the production of nitric oxide (NO).	Arginine	99-107	argininosuccinate synthase 1	Homo sapiens	0-26
15851478-1	2005	Argininosuccinate synthase (AS) catalyzes the rate-limiting step in the recycling of citrulline to arginine, which in endothelial cells, is tightly coupled to the production of nitric oxide (NO).	Arginine	99-107	argininosuccinate synthase 1	Homo sapiens	28-30
15851478-9	2005	In conclusion, the uORF found in the extended, overlapping 5"-UTR AS mRNA species suppresses endothelial AS expression, providing a novel mechanism for regulating endothelial NO production by limiting the availability of arginine.	Arginine	221-229	argininosuccinate synthase 1	Homo sapiens	66-68
15851478-9	2005	In conclusion, the uORF found in the extended, overlapping 5"-UTR AS mRNA species suppresses endothelial AS expression, providing a novel mechanism for regulating endothelial NO production by limiting the availability of arginine.	Arginine	221-229	argininosuccinate synthase 1	Homo sapiens	105-107
15855156-4	2005	The substitution of Arg in one NAD kinase with polar amino acids also relaxed the substrate specificity, whereas substitution with charged and hydrophobic amino acids did not show a similar result.	Arginine	20-23	NAD kinase	Homo sapiens	31-41
21087206-8	2011	Ozone induced marked DNA breaks, G1-phase arrest and increased expression of p-ATM in HBECs, while wortmannin reduced the levels of p-ATM induced by ozone; the NO donor, L-arg, minimized the effects of ozone-induced DNA breaks and increased the level of p-ATM, while the NO synthase inhibitor, L-NMMA [N(G)-minomethyl-L-arginine], restrained those effects of L-arg.	Arginine	170-175	ATM serine/threonine kinase	Homo sapiens	79-82
21087206-8	2011	Ozone induced marked DNA breaks, G1-phase arrest and increased expression of p-ATM in HBECs, while wortmannin reduced the levels of p-ATM induced by ozone; the NO donor, L-arg, minimized the effects of ozone-induced DNA breaks and increased the level of p-ATM, while the NO synthase inhibitor, L-NMMA [N(G)-minomethyl-L-arginine], restrained those effects of L-arg.	Arginine	170-175	ATM serine/threonine kinase	Homo sapiens	134-137
21087206-8	2011	Ozone induced marked DNA breaks, G1-phase arrest and increased expression of p-ATM in HBECs, while wortmannin reduced the levels of p-ATM induced by ozone; the NO donor, L-arg, minimized the effects of ozone-induced DNA breaks and increased the level of p-ATM, while the NO synthase inhibitor, L-NMMA [N(G)-minomethyl-L-arginine], restrained those effects of L-arg.	Arginine	170-175	ATM serine/threonine kinase	Homo sapiens	134-137
15755869-4	2005	Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs.	Arginine	37-40	C-C motif chemokine ligand 2	Homo sapiens	110-144
19553224-2	2011	No significant differences were observed in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E versus C (27% vs 8% of carriers of the Arg allele in E and C, p&lt;0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, p=0.001).	Arginine	127-130	adrenoceptor beta 3	Homo sapiens	116-121
15929701-3	2005	Amino acid substitution at 264 from arginine (R) to glycine (G), lysine (K), or threonine (T) results in a low affinity peptide that binds to HLA-B27 inefficiently and is poorly recognized by T cells that respond to the wild-type peptide.	Arginine	36-44	major histocompatibility complex, class I, B	Homo sapiens	142-149
21258366-0	2011	Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.	Arginine	18-21	EPH receptor B2	Homo sapiens	103-106
15804381-3	2005	Mutation-specific nested PCR methods to analyse DHFR (Arg-59) and DHPS (Glu-540) mutations that are associated with SP drug resistance were applied.	Arginine	54-57	dihydrofolate reductase	Homo sapiens	48-52
15731101-1	2005	We have identified in Xanthomonas campestris a novel N-acetylornithine transcarbamylase that replaces ornithine transcarbamylase in the canonic arginine biosynthetic pathway of several Eubacteria.	Arginine	144-152	ornithine transcarbamylase	Homo sapiens	61-87
21258366-5	2011	Arg 1175 methylation positively modulates EGF-induced EGFR trans-autophosphorylation at Tyr 1173, which governs ERK activation.	Arginine	0-3	EPH receptor B2	Homo sapiens	112-115
21258366-6	2011	Abolishment of Arg 1175 methylation enhances EGF-stimulated ERK activation by reducing SHP1 recruitment to EGFR, resulting in augmented cell proliferation, migration and invasion of EGFR-expressing cells.	Arginine	15-18	EPH receptor B2	Homo sapiens	60-63
21258366-7	2011	Therefore, we propose a model in which the regulatory crosstalk between PRMT5-mediated Arg 1175 methylation and EGF-induced Tyr 1173 phosphorylation attenuates EGFR-mediated ERK activation.	Arginine	87-90	EPH receptor B2	Homo sapiens	174-177
21379321-7	2011	The strongest candidate variant causes a glycine to arginine substitution in a highly conserved region of the metalloproteinase ADAMTS10.	Arginine	52-60	ADAM metallopeptidase with thrombospondin type 1 motif 10	Canis lupus familiaris	128-136
16077883-3	2005	Subsequently, it was demonstrated that the EDRF is nitric oxide (NO), produced through the metabolism of the aminoacid L-arginine by the nitric oxide synthases (NOS).	Arginine	119-129	alpha hemoglobin stabilizing protein	Homo sapiens	43-47
15741314-5	2005	Our results suggest that arginine methylation regulates the activity of MRE11-RAD50-NBS1 complex during the intra-S-phase DNA damage checkpoint response.	Arginine	25-33	nibrin	Homo sapiens	84-88
21094170-4	2011	MAIN METHODS: We designed an EGF variant (EGF(RR)) in which the two lysines were substituted with arginine (K28R and K48R).	Arginine	98-106	epidermal growth factor	Homo sapiens	29-32
15724986-2	2005	The catalyst cleaved the polypeptide backbone of PDF at Gln(152)-Arg(153).	Arginine	65-68	peptide deformylase, mitochondrial	Homo sapiens	49-52
21094170-4	2011	MAIN METHODS: We designed an EGF variant (EGF(RR)) in which the two lysines were substituted with arginine (K28R and K48R).	Arginine	98-106	epidermal growth factor	Homo sapiens	42-45
21517269-5	2011	A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype occurrence compared to the Arg/Arg genotype (odds ratio (OR) 1.698, 95% confidence interval (CI) 1.112-2.593); P= 0.0138) was observed.	Arginine	95-98	transmembrane serine protease 11A	Homo sapiens	89-94
20844281-2	2011	Arginine stimulates proliferation of ovine trophectoderm cells through MTOR-RPS6K-RPS6 signaling cascade and synthesis of nitric oxide and polyamines.	Arginine	0-8	40S ribosomal protein S6	Ovis aries	76-80
20844281-11	2011	These results indicate that L-Arg enhances production of polyamines and NO and activates the MTOR/FRAP1-RPS6K-RPS6 signaling pathway to stimulate proliferation and migration of oTr cells.	Arginine	28-33	40S ribosomal protein S6	Ovis aries	104-108
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Arginine	210-213	crystallin, gamma B	Mus musculus	64-67
20939034-4	2011	Here, we designed a novel scaffold where fibronectin-derived Gly Arg-Gly-Asp-Ser (GRGDS) and Pro-His-Ser-Arg-Asn (PHSRN) peptides were simultaneously conjugated with poly(Pro-Hyp-Gly).	Arginine	65-68	fibronectin 1	Bos taurus	41-52
15750346-1	2005	The role of residue C323 in catalysis by human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) was examined by substituting Arg, Gly, Leu, Met, or Tyr at C323 by cassette mutagenesis using synthetic human GDH isozyme genes.	Arginine	127-130	glutamate dehydrogenase 1	Homo sapiens	81-86
21959333-5	2011	In analysis of the alleles combination, a significant difference was observed in waist to hip ratio among the groups stratified by the carrying number of the alleles of beta3AR Arg, beta2AR Arg and UCP1 G (p=0.026), and the waist to hip ratio was significantly higher in the carriers of four and five risk alleles than in the carriers from zero to three risk alleles (p=0.005).	Arginine	177-180	adrenoceptor beta 3	Homo sapiens	169-176
15670186-0	2005	Tryptophan 64 --&gt; arginine polymorphism of beta-3-adrenergic receptor in Chilean women with polycystic ovary syndrome.	Arginine	21-29	adrenoceptor beta 3	Homo sapiens	46-72
21897744-6	2011	RESULTS: In hSVCT2 mice, L-arginine decreased 335/385 and 370/440 nm fluorescence by 40% (p&lt;0.001), CML, CEL, and glucosepane crystallin crosslinks by 35% (p&lt;0.05), 30% (p&lt;0.05), and 37% (p&lt;0.05), respectively, without affecting MG-H1 and G-H1.	Arginine	25-35	growth hormone	Mus musculus	241-255
22073228-0	2011	N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.	Arginine	11-20	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	62-67
15659327-0	2005	A new arginine substitution mutation of DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditaria.	Arginine	6-14	adenosine deaminase RNA specific	Homo sapiens	40-45
15642142-9	2005	In CDR exchange studies, VL containing B3VL CDR1 were associated with elevated CL binding, which was reduced significantly by substitution of a CDR1 arginine residue at position 27a with serine.	Arginine	149-157	cerebellar degeneration related protein 1	Homo sapiens	44-48
15642142-9	2005	In CDR exchange studies, VL containing B3VL CDR1 were associated with elevated CL binding, which was reduced significantly by substitution of a CDR1 arginine residue at position 27a with serine.	Arginine	149-157	cerebellar degeneration related protein 1	Homo sapiens	144-148
20156521-11	2010	PON1 polymorphisms at positions 192 (R form with arginine at 192 and Q with glutamine) and 55 (L form with a leucine and a M form with methionine) influence paroxonase activity.	Arginine	49-57	serum paraoxonase/arylesterase 1	Ovis aries	0-4
15649129-6	2005	The kAE1 (Arg(901)--&gt;stop) mutant has been studied in more detail, since the mistargeting kAE1 (Arg(901)--&gt;stop) from the basolateral to the apical membrane is consistent with the removal of a basolateral localization signal.	Arginine	10-13	O-sialoglycoprotein endopeptidase	Homo sapiens	4-8
16358414-0	2005	Role of arginine residues 14 and 15 in dictating DNA binding stability and transactivation of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator heterodimer.	Arginine	8-16	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	124-170
20980252-0	2010	Arginine 104 is a key catalytic residue in leukotriene C4 synthase.	Arginine	0-8	leukotriene C4 synthase	Homo sapiens	43-66
16271291-4	2005	PADI4 catalyzes the conversion of arginine residues to citrulline in proteins.	Arginine	34-42	peptidyl arginine deiminase 4	Homo sapiens	0-5
20980252-2	2010	From the crystal structure of hLTC(4)S, Arg-104 and Arg-31 have been implicated in the conjugation reaction.	Arginine	40-43	leukotriene C4 synthase	Homo sapiens	30-38
20980252-2	2010	From the crystal structure of hLTC(4)S, Arg-104 and Arg-31 have been implicated in the conjugation reaction.	Arginine	52-55	leukotriene C4 synthase	Homo sapiens	30-38
20980252-9	2010	We conclude that Arg-104 plays a critical role in the catalytic mechanism of hLTC(4)S, whereas a functional role of Arg-31 seems more elusive.	Arginine	17-20	leukotriene C4 synthase	Homo sapiens	77-85
21151933-1	2010	Cationic amino acid transporters (mCAT1 and mCAT2B) regulate the arginine availability in macrophages.	Arginine	65-73	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	34-39
15571384-3	2004	Pro-1 and Arg-75 are critical for both activities, and the pKa of Pro-1 was determined to be approximately 9.2 by a direct 15N NMR titration.	Arginine	10-13	lamin A/C	Homo sapiens	66-71
15642967-5	2004	The dhfr Arg-59 mutation was only predictive of treatment failure in the presence of the dhps Glu-540 mutation.	Arginine	9-12	dihydrofolate reductase	Homo sapiens	4-8
21151933-3	2010	We reveal here a novel mechanism by which Salmonella exploit mCAT1 and mCAT2B to acquire host arginine towards its own intracellular growth within antigen presenting cells.	Arginine	94-102	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	61-66
21151933-5	2010	We show that the mCAT1 transporter is in close proximity to Salmonella containing vacuole (SCV) specifically by live intracellular Salmonella in order to access the macrophage cytosolic arginine pool.	Arginine	186-194	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	17-22
20729917-4	2010	A number of candidate Crk SH3-binding proteins have been identified, including the nonreceptor tyrosine kinases c-Abl and Arg, and the guanine nucleotide exchange proteins C3G, SOS1 and DOCK180.	Arginine	122-125	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	22-25
15642967-7	2004	The dhps Glu-540 mutation played a principal role and the dhfr Arg-59 mutation a secondary role in mediating resistance to SP alone and in combination.	Arginine	63-66	dihydrofolate reductase	Homo sapiens	58-62
21079036-3	2010	Kisspeptins are members of the Arg-Phe amide family of peptides, which have been identified as endogenous ligands for a G-protein-coupled receptor encoded by a gene originally called GPR54 (also known as AXOR12 or hOT7T175).	Arginine	31-34	KISS1 receptor	Homo sapiens	214-222
15815081-7	2004	The target of photoactivated probe II, Arg 197, in a distance of about 16.5 A from the heme iron, exactly matches the position of that amino acid residue, predicted from the CYP 2B4 homology model.	Arginine	39-42	cytochrome P450 2B4	Oryctolagus cuniculus	174-181
20966198-3	2010	Both RNPS1 and Acinus contain typical motifs of splicing regulatory proteins including arginine/serine-rich domains.	Arginine	87-95	apoptotic chromatin condensation inducer 1	Homo sapiens	15-21
15537772-15	2004	As FI increased, the SID decreased linearly (P &lt; 0.04) for CP and all AA, except Arg, Trp, Asp, Pro, and Tyr.	Arginine	84-87	FEEDIN	Sus scrofa	3-5
15371428-8	2004	Like the ubiquitin fold ubiquitin regulatory X (UBX) domain in p47, the Npl4-UBD interacts with p97 via the loop between its strands 3 and 4 and a conserved arginine in strand 1.	Arginine	157-165	NSFL1 cofactor	Homo sapiens	63-66
21068368-1	2010	Editing of the pre-mRNA for the DNA repair enzyme NEIL1 causes a lysine to arginine change in the lesion recognition loop of the protein.	Arginine	75-83	nei like DNA glycosylase 1	Homo sapiens	50-55
15375167-5	2004	In silico modeling followed by mutagenesis and the in vitro and cell-based binding studies showed that the His(171)-Glu-Lys-Gln-Ala-Asp(176) and Val(223)-Arg-Asn(224) peptide sequences of MT1-MMP are directly involved in the binding with C1q.	Arginine	154-157	complement C1q A chain	Homo sapiens	238-241
15544357-3	2004	Conversion of this bond in alpha(1)-PI from Met-Ser to Arg-Ser in alpha(1)-PI Pittsburgh (M358R) redirects alpha(1)-PI from inhibiting NE to inhibiting thrombin (IIa), activated protein C (APC), and other proteases.	Arginine	55-58	colicin Ia immunity protein	Escherichia coli	162-165
21092141-9	2010	Human Fbw7 mutants with mutations of arginine residues important for recognition of the CPD still ubiquitylated human c-Myb.	Arginine	37-45	MYB proto-oncogene, transcription factor	Homo sapiens	118-123
15364944-0	2004	Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	56-95
15364944-1	2004	Components of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex and other nucleic acid-binding proteins are subject to methylation on specific arginine residues by the catalytic activity of arginine methyltransferases.	Arginine	153-161	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	18-57
15364944-1	2004	Components of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex and other nucleic acid-binding proteins are subject to methylation on specific arginine residues by the catalytic activity of arginine methyltransferases.	Arginine	153-161	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	59-64
20882568-3	2010	To study these issues, we established a cell culture model of tauopathy using a hexameric peptide with the sequence (306)VQIVYK(311) located within the third microtubule-binding repeat of tau, rendered cell-permeable by a tag of nine arginine residues (R(9)).	Arginine	234-242	microtubule associated protein tau	Homo sapiens	62-65
15494015-6	2004	Intriguingly, unlike bone-marrow-derived macrophages, SHIP1(-/-) peritoneal and alveolar macrophages produce 10-fold less NO than wild-type macrophages because these in vivo-generated macrophages have very high arginase I levels and this enzyme competes with inducible nitric oxide synthase for the substrate L-arginine.	Arginine	309-319	inositol polyphosphate-5-phosphatase D	Mus musculus	54-59
20949531-7	2010	A novel homozygous missense mutation in coding exon 4 of the WNT7A was detected in both affected daughters (c.664C &gt; T) leading to an amino acid exchange from arginine to tryptophan (p.Arg222Trp; R222W).	Arginine	162-170	Wnt family member 7A	Homo sapiens	61-66
15568289-11	2004	The absence of arginine was also associated with increased expression of AS.	Arginine	15-23	argininosuccinate synthase 1	Homo sapiens	73-75
15568289-12	2004	CONCLUSIONS: T cells exhibit the molecular capability of increasing citrulline membrane transport and up-regulating AS expression, thus exhibiting the necessary mechanisms for converting citrulline into arginine and escaping the ill effects of arginine depletion.	Arginine	203-211	argininosuccinate synthase 1	Homo sapiens	116-118
15568289-12	2004	CONCLUSIONS: T cells exhibit the molecular capability of increasing citrulline membrane transport and up-regulating AS expression, thus exhibiting the necessary mechanisms for converting citrulline into arginine and escaping the ill effects of arginine depletion.	Arginine	244-252	argininosuccinate synthase 1	Homo sapiens	116-118
20686071-5	2010	We have studied the signaling events induced in human umbilical venous endothelial cells (HUVECs) by aortic microfibrils as well as recombinant fibrillin-1 Arg-Gly-Asp (RGD)-containing fragments PF9 and PF14.	Arginine	156-159	fibrillin 1	Homo sapiens	144-155
15328419-17	2004	The heavy chain of the pathogenic APL antibody IS4 contains four exposed arginines in CDR3.	Arginine	73-82	cerebellar degeneration-related 3	Mus musculus	86-90
15476822-7	2004	Employing a modeled lamin A coil 1A dimer, we propose that the head-to-tail association of two lamin dimers involves strong electrostatic attractions of distinct clusters of negative charge located on the opposite ends of the rod domain with arginine clusters in the head domain and the first segment of the tail domain.	Arginine	242-250	lamin A/C	Homo sapiens	20-25
15476822-7	2004	Employing a modeled lamin A coil 1A dimer, we propose that the head-to-tail association of two lamin dimers involves strong electrostatic attractions of distinct clusters of negative charge located on the opposite ends of the rod domain with arginine clusters in the head domain and the first segment of the tail domain.	Arginine	242-250	lamin A/C	Homo sapiens	95-100
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	175-178	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	175-178	AGBL carboxypeptidase 2	Homo sapiens	169-173
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	183-186	coiled-coil domain containing 115	Homo sapiens	148-152
15304516-8	2004	Classical pathway regulation, both through decay acceleration and factor I cleavage of C4b, required a cluster of positively charged amino acids in CCP1 stretching into CCP2 (Arg-20, Arg-33, Arg-35, Lys-64, Lys-65, and Lys-88) as well as positively (Lys-131, Lys-133, and His-135) and negatively (Glu-99, Glu-152, and Asp-155) charged areas at opposing faces of the border region between CCPs 2 and 3.	Arginine	183-186	coiled-coil domain containing 115	Homo sapiens	148-152
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Arginine	152-160	carboxypeptidase B2 (plasma)	Mus musculus	0-18
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Arginine	152-160	carboxypeptidase B2 (plasma)	Mus musculus	20-23
15383602-1	2004	Carboxypeptidase R (CPR) is a heat-labile enzyme found in serum in addition to stable carboxypeptidase N. CPR cleaves the C-terminal basic amino acids, arginine and lysine, from inflammatory peptides such as complement C3a and C5a, bradykinin, and enkephalin.	Arginine	152-160	carboxypeptidase B2 (plasma)	Mus musculus	106-109
15555906-5	2004	When the arginines were replaced by lysines, the sensitivity to cytochrome b(5) was restored and the acyl-carbon cleavage activities were recovered.	Arginine	9-18	cytochrome b5 type A	Homo sapiens	64-79
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	60-63	cytochrome b5 type A	Homo sapiens	171-186
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	70-73	cytochrome b5 type A	Homo sapiens	171-186
15555906-7	2004	The results suggest that the bifurcated cationic charges at Arg(347), Arg(358) and Arg(449) make important contributions to the formation of catalytically competent CYP17.cytochrome b(5) complex.	Arginine	70-73	cytochrome b5 type A	Homo sapiens	171-186
15367628-4	2004	If transient ubiquitination of RSV Gag is required for budding, then replacement of the target lysine(s) with arginine should prevent the addition of Ub and reduce budding.	Arginine	110-118	Pr76 polyprotein precursor	Rous sarcoma virus	35-38
15361131-4	2004	The HLA-B*3928 allele was identified with a nucleotide substitution of G to C at position 362 when compared to the closest matched allele, HLA-B*390101, resulting in an amino acid substitution of Arginine to Threonine.	Arginine	196-204	major histocompatibility complex, class I, B	Homo sapiens	4-9
15361131-4	2004	The HLA-B*3928 allele was identified with a nucleotide substitution of G to C at position 362 when compared to the closest matched allele, HLA-B*390101, resulting in an amino acid substitution of Arginine to Threonine.	Arginine	196-204	major histocompatibility complex, class I, B	Homo sapiens	139-144
15252050-10	2004	However, it was discovered the Arg(74) mutant of TF was defective in enhancing both the amidolytic and proteolytic activity of fVIIa, suggesting that this residue may be required for the allosteric activation of the protease.	Arginine	31-34	coagulation factor III, tissue factor	Homo sapiens	49-51
15350136-8	2004	For example, both increased levels of acetylation and a previously unidentified dimethylation of both lysine and arginine residues were found on HMGA1a proteins from metastatic cells compared to proteins found in their nonmetastatic precursors.	Arginine	113-121	high mobility group AT-hook 1	Homo sapiens	145-151
15331664-7	2004	We show that the recruitment of the two serine/arginine-rich (SR) proteins SF2/ASF and SRp30c requires the presence of stress-induced satellite III transcripts.	Arginine	47-55	serine and arginine rich splicing factor 9	Homo sapiens	87-93
15334382-8	2004	Our findings suggest that the beta(2)-AR Arg(16)-Gly genotype influences T-C and LDL-C levels in an age-specific manner, that it may interact with beta(3)-AR Trp(64)-Arg genotypes to influence longitudinal T-C and LDL-C profiles, and that the effect of combined beta(2)/beta(3)-AR genotypes on T-C and LDL-C profiles may differ among race/sex groups.	Arginine	41-44	adrenoceptor beta 3	Homo sapiens	147-157
15334382-8	2004	Our findings suggest that the beta(2)-AR Arg(16)-Gly genotype influences T-C and LDL-C levels in an age-specific manner, that it may interact with beta(3)-AR Trp(64)-Arg genotypes to influence longitudinal T-C and LDL-C profiles, and that the effect of combined beta(2)/beta(3)-AR genotypes on T-C and LDL-C profiles may differ among race/sex groups.	Arginine	41-44	adrenoceptor beta 3	Homo sapiens	270-280
15178693-3	2004	Here we identify two basic amino acid residues within the L-selectin tail that are required for binding to ezrin-radixinmoesin (ERM) proteins: arginine 357 and lysine 362.	Arginine	143-151	selectin L	Homo sapiens	58-68
20653567-5	2010	However, the ability to utilize exogenous Arg precursors (ornithine and citrulline) for growth in Arg-deficient medium strongly correlated with expression of the corresponding enzymes, OTC and ASS.	Arginine	42-45	argininosuccinate synthase 1	Homo sapiens	193-196
20653567-5	2010	However, the ability to utilize exogenous Arg precursors (ornithine and citrulline) for growth in Arg-deficient medium strongly correlated with expression of the corresponding enzymes, OTC and ASS.	Arginine	98-101	argininosuccinate synthase 1	Homo sapiens	193-196
20889542-8	2010	L-Arg deprivation inhibited the expression of HuR through a global arrest in de novo protein synthesis, but it did not affect its mRNA expression.	Arginine	0-5	ELAV like RNA binding protein 1	Homo sapiens	46-49
20735721-6	2010	The heavy chain (HCh) of FVIII was proteolyzed at Arg(740) and Arg(372) more rapidly by FVIIa/TF than by thrombin, consistent with the enhanced activation of FVIII.	Arginine	63-66	coagulation factor III, tissue factor	Homo sapiens	94-96
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	19-23
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	81-85
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	106-109
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	111-116
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	159-163
20823272-4	2010	Our data show that Hmt1, the major type I arginine methyltransferase, methylates Snp1, a U1 small nuclear RNP (snRNP)-specific protein, and that the mammalian Snp1 homolog, U1-70K, is likewise arginine methylated.	Arginine	42-50	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	173-179
21039740-3	2010	Peptidyl arginine deiminase type IV (PADI4) is a member of gene family that encodes enzymes responsible for the conversion of arginine to citrulline residues.	Arginine	9-17	peptidyl arginine deiminase 4	Homo sapiens	37-42
15297092-18	2004	Arg administered both before and after CLP had a synergistic effect on improving intestinal immunity, possibly by enhancing systemic IL-10 secretion.	Arginine	0-3	interleukin 10	Rattus norvegicus	133-138
20729856-3	2010	Here we report that FEN1 is methylated at arginine residues, primarily at Arg192.	Arginine	42-50	flap structure-specific endonuclease 1	Homo sapiens	20-24
15291817-7	2004	Sequence alignment of the two analogues with several species of MBP suggests a critical role for the positively charged residue Arg78, firstly, in the stabilization of the local microdomains (epitopes) of the integral protein, and secondly, in a number of post-translational modifications relevant to multiple sclerosis, such as the conversion of charged arginine residues to uncharged citrullines.	Arginine	355-363	myelin basic protein	Cavia porcellus	64-67
20729856-6	2010	Mutations of FEN1 disrupting arginine methylation and PCNA interaction result in unscheduled phosphorylation and a failure to localize to DNA replication or repair foci.	Arginine	29-37	flap structure-specific endonuclease 1	Homo sapiens	13-17
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	208-211	H3 histone pseudogene 16	Homo sapiens	49-52
15247907-1	2004	Peptidylarginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the conversion of protein arginine residues to citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Yih1p	Saccharomyces cerevisiae S288C	0-4
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	208-211	H3 histone pseudogene 16	Homo sapiens	220-223
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	Yih1p	Saccharomyces cerevisiae S288C	69-73
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	212-215	H3 histone pseudogene 16	Homo sapiens	49-52
20732856-5	2010	In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes.	Arginine	212-215	H3 histone pseudogene 16	Homo sapiens	220-223
20692206-3	2010	The heterozygous somatic mutations at arginine R132 (IDH1) and at R140 or R172 (IDH2) in the enzyme active site confer a gain of function to the enzymes, which can both produce the metabolite 2-hydroxyglutarate.	Arginine	38-46	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	53-57
15232006-8	2004	This "zincless finger" appears to be required for NEIL1 activity, because mutating a very highly conserved arginine within this motif greatly reduces the glycosylase activity of the enzyme.	Arginine	107-115	nei like DNA glycosylase 1	Homo sapiens	50-55
20716762-5	2010	Separate studies show that, in addition to inhibiting NO synthesis by substrate limitation, reducing the availability of arginine simply by nutrient deprivation can blunt the innate immune response by impairing a specific mitogen-activated protein kinase (MAPK) pathway downstream of TLR4.	Arginine	121-129	toll like receptor 4	Homo sapiens	284-288
15123609-6	2004	The substitution of Tyr(1003) with phenylalanine or substitution of either aspartate or arginine residues with alanine impairs c-Cbl-recruitment and ubiquitination of Met and results in the oncogenic activation of the Met receptor.	Arginine	88-96	Cbl proto-oncogene	Homo sapiens	127-132
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Arginine	81-89	Cbl proto-oncogene	Homo sapiens	149-154
20716763-0	2010	TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.	Arginine	77-85	mitogen-activated protein kinase kinase kinase 8	Mus musculus	0-5
20716763-4	2010	Arginine facilitated the activation of MAPKs by preventing the dephosphorylation and inactivation of the MAPK kinase kinase tumor-promoting locus 2 (TPL-2).	Arginine	0-8	mitogen-activated protein kinase kinase kinase 8	Mus musculus	149-154
20372964-3	2010	Here we show that mutation of arginine 67 reduced self-palmitoylation of Bet3, but the effect was compensated by increasing the pH.	Arginine	30-38	trafficking protein particle complex subunit 3	Homo sapiens	73-77
15131131-1	2004	Mutational studies of T cell receptor (TCR) contact residues on the surface of the human class I major histocompatibility complex (MHC) molecule HLA-A2 have identified a "functional hot spot" that comprises Arg(65) and Lys(66) and is involved in recognition by most peptide-specific HLA-A2-restricted TCRs.	Arginine	207-210	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	22-37
15131131-1	2004	Mutational studies of T cell receptor (TCR) contact residues on the surface of the human class I major histocompatibility complex (MHC) molecule HLA-A2 have identified a "functional hot spot" that comprises Arg(65) and Lys(66) and is involved in recognition by most peptide-specific HLA-A2-restricted TCRs.	Arginine	207-210	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	39-42
15131131-6	2004	However, these effects are independent of their effects on TCR recognition, and the Arg(65)-Lys(66) region thus represents a true "hot spot" for TCR recognition.	Arginine	84-87	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	145-148
20372964-4	2010	Thus, arginine helps to deprotonate cysteine such that it could function as a nucleophile in the acylation reaction which is supported by the structural analysis of non-acylated Bet3.	Arginine	6-14	trafficking protein particle complex subunit 3	Homo sapiens	178-182
20587514-1	2010	The p53 tumor suppressor gene contains a common single nucleotide polymorphism (SNP) that results in either an arginine or proline at position 72 of the p53 protein.	Arginine	111-119	transformation related protein 53, pseudogene	Mus musculus	153-156
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Arginine	89-97	telomerase reverse transcriptase	Homo sapiens	3-8
15263827-10	2004	After reperfusion, plasma lipase in the L-arginine-treated animals was significantly lower compared to IR and sodium nitroprusside (p &lt; 0.05).	Arginine	40-50	lipase G, endothelial type	Rattus norvegicus	26-32
15240653-3	2004	Recently, we found that human endothelial cells obtained from carriers of the Arg(972) IRS-1 polymorphism exhibited reduced eNOS expression in response to chronic exposure to insulin.	Arginine	78-81	insulin receptor substrate 1	Homo sapiens	87-92
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Arginine	89-97	telomerase reverse transcriptase	Homo sapiens	67-72
15240653-5	2004	To investigate a possible relationship between Arg(972) IRS-1 polymorphism and endothelial dysfunction in vivo, we enrolled a cohort of 100 never-treated hypertensive subjects.	Arginine	47-50	insulin receptor substrate 1	Homo sapiens	56-61
15240653-8	2004	The allelic frequency of the Arg(972) IRS-1 variant was 8.0%.	Arginine	29-32	insulin receptor substrate 1	Homo sapiens	38-43
20439462-13	2010	Drosophila tan(1) null mutant analysis revealed that amino acid Arg(217) is absolutely required for processing.	Arginine	64-67	tantalus	Drosophila melanogaster	11-14
15240653-9	2004	Stratifying subjects according to IRS-1 genotype, we observed that acetylcholine-stimulated forearm blood flow was significantly (P &lt; 0.0001) lower in Gly/Arg heterozygous carriers than in Gly/Gly carriers (11.3 +/- 4.4 vs. 14.7 +/- 5.9 ml/100 ml(-1) of tissue per min(-1)).	Arginine	158-161	insulin receptor substrate 1	Homo sapiens	34-39
15240653-11	2004	Our data strongly suggest that, by inducing endothelial dysfunction, the Arg(972) IRS-1 polymorphism may contribute to the genetic predisposition to develop cardiovascular disease.	Arginine	73-76	insulin receptor substrate 1	Homo sapiens	82-87
20493979-6	2010	Furthermore, we have analysed the three-dimensional nuclear positions of MED12 and MED30 genes in the presence of l-arginine treatment.	Arginine	114-124	mediator complex subunit 12	Homo sapiens	73-78
15210823-5	2004	Among the novel peptides, Trp-Arg-Trp-Trp-Trp-Trp-CONH(2) (WRWWWW (WRW(4))) showed the most potent activity in terms of inhibiting WKYMVm binding to FPRL1.	Arginine	30-33	formyl peptide receptor 2	Homo sapiens	149-154
20486657-5	2010	As a result, the interaction between the glutaconyl carboxylate and the guanidinium group of a conserved arginine is stronger in GDH(Des) (short and planar bidentate hydrogen bond) than in the decarboxylating human GDH (longer and monodentate hydrogen bond), which is corroborated by molecular dynamics studies.	Arginine	105-113	glutamate dehydrogenase 1	Homo sapiens	129-132
15047794-6	2004	As expected, the Upf1 protein itself was down-regulated, and there were reproducible increases in expression of proteins involved in arginine biosynthesis.	Arginine	133-141	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	17-21
15033987-8	2004	Therefore, these results suggest that the N-terminal regions of FKBP12 (Gln-3 and Arg-18) and Met-49 are essential and unique for binding of FKBP12 to RyR1 in skeletal muscle.	Arginine	82-85	ryanodine receptor 1	Oryctolagus cuniculus	151-155
20486657-5	2010	As a result, the interaction between the glutaconyl carboxylate and the guanidinium group of a conserved arginine is stronger in GDH(Des) (short and planar bidentate hydrogen bond) than in the decarboxylating human GDH (longer and monodentate hydrogen bond), which is corroborated by molecular dynamics studies.	Arginine	105-113	glutamate dehydrogenase 1	Homo sapiens	215-218
20109498-4	2010	Pre-test microinjection of l-arginine (0.5, 0.75 and 1 microg/mouse), into the CA1 region of dorsal hippocampus (intra-CA1) had no effect on memory retrieval.	Arginine	27-37	carbonic anhydrase 1	Mus musculus	79-82
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Arginine	21-24	flap structure-specific endonuclease 1	Homo sapiens	64-69
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Arginine	30-33	flap structure-specific endonuclease 1	Homo sapiens	64-69
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Arginine	30-33	flap structure-specific endonuclease 1	Homo sapiens	64-69
15037610-4	2004	It was revealed that Arg(47), Arg(70), and Lys(326)-Arg(327) of FEN-1 interact with the upstream duplex of DNA substrates, whereas Lys(244)-Arg(245) interact with the downstream duplex.	Arginine	30-33	flap structure-specific endonuclease 1	Homo sapiens	64-69
20109498-4	2010	Pre-test microinjection of l-arginine (0.5, 0.75 and 1 microg/mouse), into the CA1 region of dorsal hippocampus (intra-CA1) had no effect on memory retrieval.	Arginine	27-37	carbonic anhydrase 1	Mus musculus	119-122
20109498-5	2010	However, pre-test intra-CA1 microinjection of the same doses of l-arginine interestingly inhibited ETOH-induced state-dependent memory.	Arginine	64-74	carbonic anhydrase 1	Mus musculus	24-27
15175427-5	2004	Acetylation of Lys49, conserved among Nei orthologs, or its mutation to Arg inactivates both base excision and AP lyase activities, while acetylation of Lys153 has no effect.	Arginine	72-75	8-oxoguanine DNA glycosylase	Homo sapiens	111-119
20498050-4	2010	K2P1-Lys274 is crucial: when mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1.	Arginine	45-48	potassium two pore domain channel subfamily K member 1	Homo sapiens	0-4
15161756-3	2004	IRS-1 KO beta-cells exhibited a significantly shorter increase in intracellular free Ca(2+) concentration ([Ca(2+)](i)) than controls when briefly stimulated with glucose or glyceraldehyde and when l-arginine was used to potentiate the stimulatory effect of glucose.	Arginine	198-208	insulin receptor substrate 1	Mus musculus	0-5
20555372-8	2010	The results indicated that there were significant mean increases (PRE to POST) in GET (4.1%), as well as in carbon dioxide output (4.3%) and power output (5.4%) at the GET for the ARGININE group, but no significant changes for the PLACEBO group (2.5%, 4.3%, and 3.9%, respectively).	Arginine	180-188	solute carrier family 35 member G1	Homo sapiens	73-77
15169881-9	2004	Mutation of arginine 78 of SAP, a residue critical for binding of SAP to FynT, eliminated 2B4-mediated protein tyrosine phosphorylation, implying that SAP promotes 2B4 signaling most probably by recruiting FynT.	Arginine	12-20	CD244 molecule	Homo sapiens	90-93
15169881-9	2004	Mutation of arginine 78 of SAP, a residue critical for binding of SAP to FynT, eliminated 2B4-mediated protein tyrosine phosphorylation, implying that SAP promotes 2B4 signaling most probably by recruiting FynT.	Arginine	12-20	CD244 molecule	Homo sapiens	164-167
15185439-2	2004	the mutations responsible are located in the CACNA1S gene (type 1) and in the SCN4A gene (type 2), and are all missense mutations where arginine is mostly replaced by histidine or sometimes glycine.	Arginine	136-144	sodium voltage-gated channel alpha subunit 4	Homo sapiens	78-83
20471598-4	2010	Based on adsorption yield and residual activity of glutathione S-transferase (GST) after fusion with the PS19-6 peptide or its variants, it was found that the basic amino acid in the PS-tags, i.e., Arg was essential for the strong binding affinity of PS-tags in both the peptide and peptide-fused protein forms The aliphatic amino acids in PS19-6 and PS19-6L, such as Ile or Leu, were also effective.	Arginine	198-201	glutathione S-transferase kappa 1	Homo sapiens	51-76
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Arginine	160-168	carboxypeptidase B2 (plasma)	Mus musculus	0-43
15099284-3	2004	Thrombin-activatable fibrinolysis inhibitor (TAFI) is a circulating carboxypeptidase B-type proenzyme that, after activation, removes carboxyterminal lysine or arginine residues in fibrin, resulting in decreased plasminogen activation and attenuated fibrinolysis.	Arginine	160-168	carboxypeptidase B2 (plasma)	Mus musculus	45-49
20471598-4	2010	Based on adsorption yield and residual activity of glutathione S-transferase (GST) after fusion with the PS19-6 peptide or its variants, it was found that the basic amino acid in the PS-tags, i.e., Arg was essential for the strong binding affinity of PS-tags in both the peptide and peptide-fused protein forms The aliphatic amino acids in PS19-6 and PS19-6L, such as Ile or Leu, were also effective.	Arginine	198-201	glutathione S-transferase kappa 1	Homo sapiens	78-81
20463604-4	2010	The experimental data show that activation of alternatively activated macrophages (aaMacs) within type-2 infiltrates by IL-4 or IL-13 can inhibit B16-F1 melanoma cell proliferation through a mechanism that is dependent on arginase-1 depletion of L-arginine within the tumor cell microenvironment.	Arginine	246-256	interleukin 4	Mus musculus	120-124
14715665-1	2004	The three mammalian nitric-oxide synthases produce NO from arginine in a reaction requiring 3 electrons per NO, which are supplied to the catalytic center from NADPH through reductase domains incorporating FAD and FMN cofactors.	Arginine	59-67	formin 1	Homo sapiens	214-217
19731076-4	2010	BmRBP1-PA and BmRBP1-PD contain a N terminal RNA recognization motif (RRM) and a C terminal arginine/serine-rich domain, while BmRBP1-PB and BmRBP1-PC only share a RRM.	Arginine	92-100	RNA-binding protein 1	Bombyx mori	0-6
14970240-3	2004	To support this proposal, RNA interference analysis was used to selectively reduce the expression of argininosuccinate synthase (AS), because the only known metabolic role for AS in endothelial cells is in the regeneration of l-arginine from l-citrulline.	Arginine	226-236	argininosuccinate synthase 1	Homo sapiens	101-127
14970240-3	2004	To support this proposal, RNA interference analysis was used to selectively reduce the expression of argininosuccinate synthase (AS), because the only known metabolic role for AS in endothelial cells is in the regeneration of l-arginine from l-citrulline.	Arginine	226-236	argininosuccinate synthase 1	Homo sapiens	129-131
19731076-4	2010	BmRBP1-PA and BmRBP1-PD contain a N terminal RNA recognization motif (RRM) and a C terminal arginine/serine-rich domain, while BmRBP1-PB and BmRBP1-PC only share a RRM.	Arginine	92-100	RNA-binding protein 1	Bombyx mori	14-20
14970240-3	2004	To support this proposal, RNA interference analysis was used to selectively reduce the expression of argininosuccinate synthase (AS), because the only known metabolic role for AS in endothelial cells is in the regeneration of l-arginine from l-citrulline.	Arginine	226-236	argininosuccinate synthase 1	Homo sapiens	176-178
19731076-4	2010	BmRBP1-PA and BmRBP1-PD contain a N terminal RNA recognization motif (RRM) and a C terminal arginine/serine-rich domain, while BmRBP1-PB and BmRBP1-PC only share a RRM.	Arginine	92-100	RNA-binding protein 1	Bombyx mori	14-20
15084284-9	2004	Phosphorylation by Arg also promotes p190RhoGAP"s association with p120RasGAP and stimulates p190RhoGAP"s ability to induce neuritogenesis in neuroblastoma cells.	Arginine	19-22	RAS p21 protein activator 1	Mus musculus	67-77
19731076-4	2010	BmRBP1-PA and BmRBP1-PD contain a N terminal RNA recognization motif (RRM) and a C terminal arginine/serine-rich domain, while BmRBP1-PB and BmRBP1-PC only share a RRM.	Arginine	92-100	RNA-binding protein 1	Bombyx mori	14-20
20393858-6	2010	In pancreatic islets isolated from Trpm5 (-/-) -mice, hyperglycemia as well as arginine-induced insulin secretion was diminished.	Arginine	79-87	transient receptor potential cation channel, subfamily M, member 5	Mus musculus	35-40
20567615-5	2010	The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric oxide production more effective and contributing to its toxic effects.	Arginine	148-156	argininosuccinate lyase	Rattus norvegicus	61-84
15071093-7	2004	Expression of wild-type GluR1 flip, however, with a mutant form of the same subunit carrying an arginine residue at the glutamine/arginine site (GluR1(R) flip) demonstrated a lack of dominance of GluR1(R) in determination of ion selectivity, whereas expression of GluR1(R) flip with GluR1 flop reproduced the pattern of apparent complete dominance.	Arginine	96-104	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	145-150
15071093-7	2004	Expression of wild-type GluR1 flip, however, with a mutant form of the same subunit carrying an arginine residue at the glutamine/arginine site (GluR1(R) flip) demonstrated a lack of dominance of GluR1(R) in determination of ion selectivity, whereas expression of GluR1(R) flip with GluR1 flop reproduced the pattern of apparent complete dominance.	Arginine	96-104	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	145-150
15071093-7	2004	Expression of wild-type GluR1 flip, however, with a mutant form of the same subunit carrying an arginine residue at the glutamine/arginine site (GluR1(R) flip) demonstrated a lack of dominance of GluR1(R) in determination of ion selectivity, whereas expression of GluR1(R) flip with GluR1 flop reproduced the pattern of apparent complete dominance.	Arginine	96-104	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	145-150
15071093-7	2004	Expression of wild-type GluR1 flip, however, with a mutant form of the same subunit carrying an arginine residue at the glutamine/arginine site (GluR1(R) flip) demonstrated a lack of dominance of GluR1(R) in determination of ion selectivity, whereas expression of GluR1(R) flip with GluR1 flop reproduced the pattern of apparent complete dominance.	Arginine	96-104	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	145-150
20685276-3	2010	JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA-splicing-related proteins.	Arginine	90-98	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
15027881-1	2004	The structure-activity requirements of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH(2) 4 were investigated by varying the position, structure, and charge of the Arg residues.	Arginine	62-65	transcription factor like 5	Homo sapiens	68-71
14702345-0	2004	Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions.	Arginine	123-131	defensin, alpha, 20	Mus musculus	90-100
14702345-2	2004	Here, site-directed Arg to Asp mutations in Crp4 have been shown to attenuate or eliminate microbicidal activity against all of the bacterial species tested regardless of the Arg residue position.	Arginine	20-23	defensin, alpha, 20	Mus musculus	44-48
20228838-5	2010	Moreover, in response to EGF, ERK translocated to the plasma membrane in cells expressing FRS2beta but not an FRS2beta mutant in which four arginine residues in the D domains were replaced with alanines, suggesting that FRS2beta serves as a plasma membrane anchor for activated ERK.	Arginine	140-148	EPH receptor B2	Homo sapiens	30-33
20200225-4	2010	Mutation analyses of MyoK revealed that both a C-terminal farnesylation membrane anchor and a Gly-Pro-Arg domain that interacts with profilin and Abp1 were necessary for proper localization in the furrow and efficient phagocytosis.	Arginine	102-105	Abp1p	Saccharomyces cerevisiae S288C	146-150
14702345-2	2004	Here, site-directed Arg to Asp mutations in Crp4 have been shown to attenuate or eliminate microbicidal activity against all of the bacterial species tested regardless of the Arg residue position.	Arginine	175-178	defensin, alpha, 20	Mus musculus	44-48
14702345-5	2004	Partial restoration of (R31D/R32D)-Crp4 bactericidal activity occurred when an electropositive Arg for Gly substitution was introduced at the peptide N terminus and the (G1R/R31D/R32D)-Crp4 peptide exhibited intermediate membrane binding capability.	Arginine	95-98	defensin, alpha, 20	Mus musculus	35-39
14702345-8	2004	Thus, Arg residues function as determinants of Crp4 bactericidal activity by facilitating or enabling target cell membrane disruption.	Arginine	6-9	defensin, alpha, 20	Mus musculus	47-51
20156196-4	2010	Two arginine residues of endostatin, Arg27 and Arg139, are crucial for its binding to TG-2.	Arginine	4-12	collagen type XVIII alpha 1 chain	Homo sapiens	25-35
14985069-4	2004	RESULTS: Arginine-aminopeptidase found in cardiac fibroblasts (Fb) was arginine and lysine specific, sensitive to various aminopeptidase (AP) inhibitors and to the inhibitor of metalloproteases, 1.10-phenatroline.	Arginine	71-79	arginyl aminopeptidase	Rattus norvegicus	9-32
20180640-7	2010	KLK2 proteolyzed IGFBP-3 into several small fragments, mostly after Arg residues, in keeping with the trypsin-like activity of KLK2.	Arginine	68-71	insulin like growth factor binding protein 3	Homo sapiens	17-24
20376793-7	2010	RESULTS: A novel missense mutation, CAC to CGC, was found at codon 283 of the ABCD1 gene from the patient, resulting in the replacement of histidine by arginine.	Arginine	152-160	ATP binding cassette subfamily D member 1	Homo sapiens	78-83
15055271-8	2004	RESULTS: We identified a novel T to C missense mutation expected to result in substitution of arginine for a conserved cysteine in the ligand-binding domain of BMPR2.	Arginine	94-102	bone morphogenetic protein receptor type 2	Homo sapiens	160-165
20075158-0	2010	Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.	Arginine	20-23	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	77-85
14757173-9	2004	Prolonged L-arginine administration produced significant functional tolerance to morphine in NOS-competent and eNOS-deficient mice.	Arginine	10-20	nitric oxide synthase 3, endothelial cell	Mus musculus	111-115
14739935-6	2004	Structural analysis and mutagenesis show that binding of N-Aha1 promotes a conformational switch in the middle-segment catalytic loop (370-390) of Hsp90 that releases the catalytic Arg 380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone.	Arginine	181-184	heat shock protein 90 alpha family class A member 1	Homo sapiens	147-152
20075158-0	2010	Amino acid residues Arg(659), Arg(660), and Tyr(661) in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor.	Arginine	30-33	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	77-85
20075158-4	2010	A deletion of all these 6 amino acid residues (ie, Arg(659)-Glu(664)) from the ADAMTS13 spacer domain resulted in dramatically reduced proteolytic activity toward VWF73 peptides, guanidine-HCl denatured VWF, and native VWF under fluid shear stress, as well as ultralarge VWF on endothelial cells.	Arginine	51-54	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	79-87
19455393-6	2010	The production of NO as reflected by an increased citrulline/arginine ratio (Cit/Arg ratio) was enhanced during development of clinical dementia.	Arginine	61-69	citron rho-interacting serine/threonine kinase	Homo sapiens	77-80
14555655-6	2004	This structure provides an explanation for the preference of HLA-B27 for a peptide with an N-terminal arginine as secondary anchor and the lack of preference for tyrosine as peptide C terminus in B*2709.	Arginine	102-110	major histocompatibility complex, class I, B	Homo sapiens	61-68
19477666-7	2010	Sequence analysis of COL4A1 revealed the heterozygous missense mutation c.2263G--&gt;A in exon 30, responsible for a glycine-to-arginine substitution (p.Gly755Arg) in both the index case and mother.	Arginine	128-136	collagen type IV alpha 1 chain	Homo sapiens	21-27
15625577-1	2004	Peptidylarginine deiminase (PAD) catalyzes the post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
14613973-1	2004	Identical proline--&gt;arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis syndromes, respectively.	Arginine	23-31	fibroblast growth factor receptor 2	Homo sapiens	118-123
20148947-8	2010	A systematic analysis of mutant Mhr1 proteins revealed that Asp69 is involved in Mg(2+)-dependent DNA binding, and that multiple Lys and Arg residues located around Trp71 and Trp165 are involved in the DNA-binding activity of Mhr1.	Arginine	137-140	Mhr1p	Saccharomyces cerevisiae S288C	32-36
15638127-11	2004	Higher arginine consumption was observed in BMMphi from both strains upon activation with IL-4 or IFNgamma which further increased, in this case, when the cells were infected with MHV3.	Arginine	7-15	interleukin 4	Mus musculus	90-94
20133688-2	2010	The NFAT-interacting protein, (NIP45), augments NFAT-driven IL-4 expression by a mechanism that relies on arginine methylation.	Arginine	106-114	interleukin 4	Mus musculus	60-64
15068667-8	2004	IL13.K105R mutant, in which lysine was substituted by arginine, neutralized the killing of IL13Ralpha2-positive cells by IL13-based cytotoxin more efficiently than wild-type IL13.	Arginine	54-62	interleukin 13 receptor subunit alpha 1	Homo sapiens	91-101
20142617-6	2010	The mutation, HSPB3(R7S), is located in the N-terminal domain and involves the loss of a conserved arginine.	Arginine	99-107	heat shock protein family B (small) member 3	Homo sapiens	14-19
14651991-3	2003	In this work numerous proline/arginine-rich cathelicidin peptides were purified, including the originally predicted OaBac5 and another OaBac5 variant.	Arginine	30-38	cathelicidin-2	Ovis aries	44-56
15028568-4	2003	Herein we describe the capacity of another arginine pathway, the metabolism of arginine to agmatine by arginine decarboxylase (ADC), to aid in this interregulation.	Arginine	43-51	antizyme inhibitor 2	Homo sapiens	103-125
15028568-4	2003	Herein we describe the capacity of another arginine pathway, the metabolism of arginine to agmatine by arginine decarboxylase (ADC), to aid in this interregulation.	Arginine	43-51	antizyme inhibitor 2	Homo sapiens	127-130
15028568-4	2003	Herein we describe the capacity of another arginine pathway, the metabolism of arginine to agmatine by arginine decarboxylase (ADC), to aid in this interregulation.	Arginine	79-87	antizyme inhibitor 2	Homo sapiens	103-125
15028568-4	2003	Herein we describe the capacity of another arginine pathway, the metabolism of arginine to agmatine by arginine decarboxylase (ADC), to aid in this interregulation.	Arginine	79-87	antizyme inhibitor 2	Homo sapiens	127-130
19783080-10	2010	Levels of gut tissue cytokines were significantly altered with enteral Arg supplementation: levels of IL-4 and IL-10 were increased, and levels of IFN-gamma and IL-2 declined, when compared with the EN-fed mice (p&lt;0.05).	Arginine	71-74	interleukin 4	Mus musculus	102-106
19783080-10	2010	Levels of gut tissue cytokines were significantly altered with enteral Arg supplementation: levels of IL-4 and IL-10 were increased, and levels of IFN-gamma and IL-2 declined, when compared with the EN-fed mice (p&lt;0.05).	Arginine	71-74	interleukin 2	Mus musculus	161-165
14690597-5	2003	By modeling ubiquitin into the NEDD8 binding site and performing mutational analysis, we identify a single conserved arginine in APPBP1-UBA3 that acts as a selectivity gate, preventing misactivation of ubiquitin by NEDD8"s E1.	Arginine	117-125	NEDD8 activating enzyme E1 subunit 1	Homo sapiens	129-135
20035717-0	2010	Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.	Arginine	39-47	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	0-4
20080556-6	2010	The targeting species employed in this work is a cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) that binds to the stress-related protein, p32, which we find to be upregulated on the surface of tumor-associated cells upon thermal treatment.	Arginine	103-106	complement component 1, q subcomponent binding protein	Mus musculus	166-169
14996430-6	2003	Both agents and L-arginine reduced the expression of collagen I (but not collagen III) and the myofibroblast marker, alpha-smooth muscle actin, as determined by immunocytochemistry and quantitative image analysis.	Arginine	16-26	actin gamma 2, smooth muscle	Rattus norvegicus	117-142
20110615-0	2010	Tau phosphorylated at tyrosine 394 is found in Alzheimer"s disease tangles and can be a product of the Abl-related kinase, Arg.	Arginine	123-126	microtubule associated protein tau	Homo sapiens	0-3
14983093-3	2003	In this paper, we describe the isolation by phage display of human epidermal growth factor (EGF) variants without lysine and a reduced number of arginine residues.	Arginine	145-153	epidermal growth factor	Homo sapiens	67-90
14983093-3	2003	In this paper, we describe the isolation by phage display of human epidermal growth factor (EGF) variants without lysine and a reduced number of arginine residues.	Arginine	145-153	epidermal growth factor	Homo sapiens	92-95
20110615-8	2010	We report, for the first time, that Arg, the other member of the Abl family of tyrosine kinases, also phosphorylates tau at Y394 in a manner independent of Abl activity.	Arginine	36-39	microtubule associated protein tau	Homo sapiens	117-120
14607331-2	2003	One polymorphism in the p21 codon 31 produces variant proteins with an amino acid change (serine (ser) or arginine (arg)).	Arginine	106-114	H3 histone pseudogene 16	Homo sapiens	24-27
20110615-9	2010	Given the reported role of Arg in oxidative stress response and neural development, the ability to phosphorylate tau at Y394 implicates Arg as a potential player in the pathogenesis of Alzheimer"s disease and other tauopathies.	Arginine	136-139	microtubule associated protein tau	Homo sapiens	113-116
14607331-2	2003	One polymorphism in the p21 codon 31 produces variant proteins with an amino acid change (serine (ser) or arginine (arg)).	Arginine	106-109	H3 histone pseudogene 16	Homo sapiens	24-27
20686326-7	2010	The results in this study showed that the Arg allele of the ADRB3 is associated with long-term changes in body weight in obese individuals.	Arginine	42-45	adrenoceptor beta 3	Homo sapiens	60-65
12963733-4	2003	The binding site on Chk1 involves a positively charged cluster of amino acids that contains lysine 54, arginine 129, threonine 153, and arginine 162.	Arginine	103-111	checkpoint kinase 1 S homeolog	Xenopus laevis	20-24
12963733-4	2003	The binding site on Chk1 involves a positively charged cluster of amino acids that contains lysine 54, arginine 129, threonine 153, and arginine 162.	Arginine	136-144	checkpoint kinase 1 S homeolog	Xenopus laevis	20-24
20453439-5	2010	For instance, PADI4 gene encoding an enzyme that converts arginine residues to citrullines may enhance the production of auto-antigens.	Arginine	58-66	peptidyl arginine deiminase 4	Homo sapiens	14-19
14597182-7	2003	The SNP at +16, which changes codon -19 (relative to the start of the mature hGGH protein) in the endoplasmic reticulum targeting sequence of hGGH protein from cysteine to arginine, has previously been identified in this laboratory.	Arginine	172-180	gamma-glutamyl hydrolase	Homo sapiens	77-81
14597182-7	2003	The SNP at +16, which changes codon -19 (relative to the start of the mature hGGH protein) in the endoplasmic reticulum targeting sequence of hGGH protein from cysteine to arginine, has previously been identified in this laboratory.	Arginine	172-180	gamma-glutamyl hydrolase	Homo sapiens	142-146
20524403-6	2010	Also, homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing cervical adenocarcinoma (OR 2.07; 95% CI 1.13-3.79) compared to genotypes containing the Arg allele.	Arginine	189-192	H3 histone pseudogene 16	Homo sapiens	33-36
12960019-3	2003	Systematic alteration of GR DBD amino acids in these chimeras to VDR DBD residues identified arg-49 and lys-53, just C-terminal of the P-box within the base recognition alpha-helix of human VDR (hVDR), as the only two amino acids among 36 differences required to convert the GR core zinc finger domain to that of the VDR.	Arginine	93-96	vitamin D receptor	Rattus norvegicus	65-68
12960019-5	2003	Thus, for RXR heterodimerizing receptors like VDR, the P-box requires redefinition and expansion to include a DNA specificity element corresponding to arg-49 and lys-53 of hVDR.	Arginine	151-154	vitamin D receptor	Rattus norvegicus	46-49
19882657-4	2010	The Arg-Gly-Asp (RGD)-binding site recognition by P11 was site specific because the P11 was inactive for the complex formation of a denatured form of integrin-vitronectin.	Arginine	4-7	endonuclease, poly(U) specific	Homo sapiens	50-53
14573629-4	2003	In this study we characterized a Lys/Arg polymorphism at position 29 in the N-terminal region of human lactoferrin that results from a single nucleotide polymorphism in exon 1 of the human lactoferrin gene.	Arginine	37-40	lactotransferrin	Bos taurus	103-114
14573629-4	2003	In this study we characterized a Lys/Arg polymorphism at position 29 in the N-terminal region of human lactoferrin that results from a single nucleotide polymorphism in exon 1 of the human lactoferrin gene.	Arginine	37-40	lactotransferrin	Bos taurus	189-200
14573629-7	2003	When tested against the gram-positive species Streptococcus mutans and Streptococcus mitis, however, lactoferrin containing Lys at position 29 exhibited significantly greater bactericidal activity than did lactoferrin containing Arg.	Arginine	229-232	lactotransferrin	Bos taurus	206-217
19882657-4	2010	The Arg-Gly-Asp (RGD)-binding site recognition by P11 was site specific because the P11 was inactive for the complex formation of a denatured form of integrin-vitronectin.	Arginine	4-7	endonuclease, poly(U) specific	Homo sapiens	84-87
14573629-8	2003	In addition, the Lys-containing lactoferrin stimulated bovine tracheal epithelial cells to synthesize much higher levels of tracheal antimicrobial peptide mRNA than did the Arg-containing variant.	Arginine	173-176	lactotransferrin	Bos taurus	32-43
19926723-2	2010	They bind piRNAs and contain symmetrically dimethylated arginines (sDMAs), catalyzed by dPRMT5.	Arginine	56-65	capsuleen	Drosophila melanogaster	88-94
19877579-5	2009	Here we show that Arg to Ala point mutagenesis of the heparin binding motif does not interrupt the folding of endostatin but significantly impairs the interaction between endostatin and nucleolin.	Arginine	18-21	collagen type XVIII alpha 1 chain	Homo sapiens	171-181
19877579-7	2009	Taken together, the present study demonstrates that the arginine clusters in the heparin binding motif of endostatin significantly contribute to its interaction with receptor nucleolin and mediate the antiangiogenic and antitumor activities of endostatin.	Arginine	56-64	collagen type XVIII alpha 1 chain	Homo sapiens	106-116
14559116-3	2003	The alpha-L-iduronidase missense mutations R89Q and R89W were investigated and altered an important arginine residue proposed to be a nucleophile activator in the catalytic mechanism of alpha-L-iduronidase.	Arginine	100-108	alpha-L-iduronidase	Homo sapiens	4-23
19877579-7	2009	Taken together, the present study demonstrates that the arginine clusters in the heparin binding motif of endostatin significantly contribute to its interaction with receptor nucleolin and mediate the antiangiogenic and antitumor activities of endostatin.	Arginine	56-64	collagen type XVIII alpha 1 chain	Homo sapiens	244-254
14559116-3	2003	The alpha-L-iduronidase missense mutations R89Q and R89W were investigated and altered an important arginine residue proposed to be a nucleophile activator in the catalytic mechanism of alpha-L-iduronidase.	Arginine	100-108	alpha-L-iduronidase	Homo sapiens	186-205
19626700-2	2009	We tested the hypothesis that the common nonsynonymous genetic variants in M6P/IGF2R c.901C &gt; G (Leu &gt; Val) in exon 6 and c.5002G &gt; A (Gly &gt; Arg) in exon 34 are associated with risk of esophageal and gastric cancers.	Arginine	153-156	insulin like growth factor 2 receptor	Homo sapiens	75-84
14523228-6	2003	The catalytic properties of the Arg-35 mutant were changed so that PC activation by the mutant no longer required Ca2+ in the presence of TM, but, instead, it was accelerated by EDTA.	Arginine	32-35	thrombomodulin	Homo sapiens	138-140
14523228-8	2003	These results suggest that Arg-35 is responsible for the Ca2+ dependence of PC activation by the thrombin-TM complex and that a function for TM in the activation complex is the allosteric alleviation of the inhibitory interaction of Arg-35 with the substrate.	Arginine	27-30	thrombomodulin	Homo sapiens	106-108
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Arginine	34-42	Cbl proto-oncogene	Homo sapiens	91-94
19798595-7	2009	Fibulin-5 contains an evolutionally conserved arginine-glycine-aspartic acid (RGD) motif in the N-terminal region, which mediates binding to a subset of integrins, including alpha5beta1, alphavbeta3, and alphavbeta5.	Arginine	46-54	fibulin 5	Mus musculus	0-9
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Arginine	120-123	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	83-86
19699269-4	2009	For L-arginine, there were age-related increases in CA1 and the perirhinal and temporal cortices, and decreases in the entorhinal and postrhinal cortices.	Arginine	4-14	carbonic anhydrase 1	Rattus norvegicus	52-55
12852784-9	2003	Previous structural studies implicated Arg-175 in the orientation of alpha-halo acid substrates in the active site of hGSTZ1-1.	Arginine	39-42	glutathione S-transferase zeta 1	Homo sapiens	118-126
19918066-0	2009	Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.	Arginine	77-85	tudor and KH domain containing protein	Mus musculus	55-60
12941294-2	2003	mAPP can inactivate bradykinin, a potent vasodilating and cardioprotective peptide hormone, by hydrolyzing the Arg(1)-Pro(2) bond.	Arginine	111-114	amyloid beta (A4) precursor protein	Mus musculus	0-4
19918066-0	2009	Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.	Arginine	77-85	tudor	Drosophila melanogaster	61-66
19918066-0	2009	Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi.	Arginine	77-85	piwi-like RNA-mediated gene silencing 1	Mus musculus	97-101
12962485-4	2003	Of these, one encoding the peptide Glu-Cys-Leu-Arg-Ser-Val-Val-Thr-Cys on gpVIII most avidly bound TF(1-218), as did the synthetic peptide.	Arginine	47-50	coagulation factor III, tissue factor	Homo sapiens	99-101
19918066-5	2009	In addition, mass spectrometry indicates that arginine residues in RG repeats at the N-termini of Miwi and Mili are methylated in vivo.	Arginine	46-54	piwi-like RNA-mediated gene silencing 1	Mus musculus	98-102
12956948-4	2003	RESULTS: X-ray crystallographic analysis of the Cdc42-RhoGDI complex suggested that arginine 66 of Cdc42 is essential for its interaction with RhoGDI.	Arginine	84-92	Rho GDP dissociation inhibitor alpha	Homo sapiens	54-60
19918066-8	2009	Furthermore, we have solved the crystal structure of the Tdrkh Tudor domain, which revealed an aromatic binding pocket and negatively charged binding surface appropriate for accommodating methylated arginine.	Arginine	199-207	tudor and KH domain containing protein	Mus musculus	57-62
19918066-8	2009	Furthermore, we have solved the crystal structure of the Tdrkh Tudor domain, which revealed an aromatic binding pocket and negatively charged binding surface appropriate for accommodating methylated arginine.	Arginine	199-207	tudor	Drosophila melanogaster	63-68
14628939-4	2003	Three other mutations (DHFR Arg-59, DHPS Gly-437, and DHPS Glu-540) were associated with clinical treatment failure after 14 days, although associations were not significant.	Arginine	28-31	dihydrofolate reductase	Homo sapiens	23-27
19897717-0	2009	ADP-ribosylation of human defensin HNP-1 results in the replacement of the modified arginine with the noncoded amino acid ornithine.	Arginine	84-92	HNP1	Homo sapiens	35-40
14628939-6	2003	The presence of both the DHFR Arg-59 and DHPS Glu-540 mutations had the strongest association with clinical treatment failure (odds ratio = 10.7, P = 0.009).	Arginine	30-33	dihydrofolate reductase	Homo sapiens	25-29
14656046-2	2003	NO is synthesized from L-arginine by NO synthase occurring in three isoforms of (neuronal, nNOS; endothelial, eNOS; inducible, iNOS).	Arginine	23-33	nitric oxide synthase 3, endothelial cell	Mus musculus	110-114
19897717-4	2009	ART1 on the surface of airway epithelial cells ADP-ribosylated HNP-1 specifically on arginines 14 and 24, with ADP-ribosylation altering biological activity.	Arginine	85-94	HNP1	Homo sapiens	63-68
19741270-7	2009	Our data represent the first experimental evidence that protein arginine methylation plays a role in ZNF224-mediated transcriptional repression and provide novel insight into the chromatin modifications required for repression of gene transcription by Kruppel-like associated box-zinc finger proteins.	Arginine	64-72	zinc finger protein 224	Homo sapiens	101-107
12867984-7	2003	Replacement of three arginine residues unique to the HA-stretch of the 5-HT3A subunit by their 5-HT3B subunit counterparts increased single-channel conductance 28-fold.	Arginine	21-29	5-hydroxytryptamine receptor 3B	Homo sapiens	95-101
19924293-8	2009	The basic arginine-lysine-lysine-arginine (RKKR) sequence, located 12-aa from the C-terminal end of Foxp3 was previously reported to be a nuclear localization signal (NLS) for several proteins, including for a GFP-Foxp3 hybrid.	Arginine	10-18	forkhead box P3	Mus musculus	100-105
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Arginine	77-85	pleckstrin	Homo sapiens	108-111
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Arginine	77-85	pleckstrin	Homo sapiens	179-182
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Arginine	287-295	pleckstrin	Homo sapiens	108-111
12650641-2	2003	In response to phagocyte activation, several serine residues in a C-terminal arginine/lysine-rich domain of p47-phox are phosphorylated, leading to changes in the conformation of p47-phox and exposure of its N-terminal SH3 domain that is normally masked by internal association with the arginine/lysine-rich domain.	Arginine	287-295	pleckstrin	Homo sapiens	179-182
19924293-8	2009	The basic arginine-lysine-lysine-arginine (RKKR) sequence, located 12-aa from the C-terminal end of Foxp3 was previously reported to be a nuclear localization signal (NLS) for several proteins, including for a GFP-Foxp3 hybrid.	Arginine	10-18	forkhead box P3	Mus musculus	214-219
19843180-3	2009	We have evaluated the functional and conformational effects on antithrombin of citrullination, a post-translational modification catalyzed by peptidylarginine deiminase (PAD), which changes arginine to citrulline.	Arginine	150-158	serpin family C member 1	Homo sapiens	63-75
12650641-4	2003	Recombinant p47-phox proteins with mutations in either the linker region or the arginine/lysine-rich domain were active in the absence of arachidonic acid stimulation in a cell-free NADPH oxidase system consisting of recombinant p67-phox, Rac1-guanosine 5"-[gamma-thio]triphosphate and neutrophil membranes.	Arginine	80-88	pleckstrin	Homo sapiens	12-15
19524607-7	2009	Interestingly, ednrb activates the L-arginine/NO/cGMP pathway that is involved in the relaxation of the cavernous body.	Arginine	35-45	endothelin receptor type B	Mus musculus	15-20
12704728-3	2003	NO is produced from l-arginine by the enzyme, nitric oxide synthase (NOS), which has three isoforms: endothelial (NOS3), neural (NOS1), and inducible (NOS2).	Arginine	20-30	nitric oxide synthase 3, endothelial cell	Mus musculus	114-118
12756332-5	2003	This assay is based on the fact that the Hmt1 enzyme utilizes S-Adenosyl-L-methionine as the methyl donor for protein arginine methylation.	Arginine	118-126	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	41-45
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Arginine	84-92	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	59-63
12709047-1	2003	Argininosuccinate synthetase (ASS, EC 6.3.4.5) catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine.	Arginine	156-164	argininosuccinate synthase 1	Homo sapiens	0-28
19706600-6	2009	Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation.	Arginine	84-92	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	119-123
12709047-1	2003	Argininosuccinate synthetase (ASS, EC 6.3.4.5) catalyses the condensation of citrulline and aspartate to form argininosuccinate, the immediate precursor of arginine.	Arginine	156-164	argininosuccinate synthase 1	Homo sapiens	30-33
12709047-4	2003	Depending on arginine utilization, location and regulation of ASS are quite different.	Arginine	13-21	argininosuccinate synthase 1	Homo sapiens	62-65
19213874-5	2009	The results demonstrate that insulin-induced hypercontractility after 8 days of tissue culture was fully prevented by combined treatment of BTSM-strips with the laminin competing peptides Tyr-Ile-Gly-Ser-Arg (YIGSR) and Arg-Gly-Asp-Ser (RGDS).	Arginine	204-207	insulin	Bos taurus	29-36
12709047-5	2003	In the liver, where arginine is hydrolyzed to form urea and ornithine, the ASS gene is highly expressed, and hormones and nutrients constitute the major regulating factors: (a) glucocorticoids, glucagon and insulin, particularly, control the expression of this gene both during development and adult life; (b) dietary protein intake stimulates ASS gene expression, with a particular efficiency of specific amino acids like glutamine.	Arginine	20-28	argininosuccinate synthase 1	Homo sapiens	75-78
12709047-6	2003	In contrast, in NO-producing cells, where arginine is the direct substrate in the NO synthesis, ASS gene is expressed at a low level and in this way, proinflammatory signals constitute the main factors of regulation of the gene expression.	Arginine	42-50	argininosuccinate synthase 1	Homo sapiens	96-99
19213874-5	2009	The results demonstrate that insulin-induced hypercontractility after 8 days of tissue culture was fully prevented by combined treatment of BTSM-strips with the laminin competing peptides Tyr-Ile-Gly-Ser-Arg (YIGSR) and Arg-Gly-Asp-Ser (RGDS).	Arginine	220-223	insulin	Bos taurus	29-36
19423266-8	2009	An Arg>Pro switch missense mutation was found in codon 265 of the hMLH1 gene.	Arginine	3-6	mutL homolog 1	Homo sapiens	66-71
12763806-0	2003	Single mutation of Lys or Arg residue in ATP binding pocket in rat Na/K-ATPase alpha-1 subunit induces different affinity change in high- and low-affinity ATP binding.	Arginine	26-29	ATPase Na+/K+ transporting subunit alpha 1	Rattus norvegicus	67-94
12653562-7	2003	A tryptic digestion map of HPLC-purified HMGA1a protein showed that methylation occurs at arginine 25 in the consensus G(24)R(25)G(26) that belongs to one of the DNA-binding AT-hooks of the protein.	Arginine	90-98	high mobility group AT-hook 1	Homo sapiens	41-47
19562367-5	2009	Moreover, in Xenopus oocytes coexpressing 4F2hc and y(+)LAT2, leucine exerts a marked inhibition of arginine transport, partially dependent on sodium, while no inhibition is seen in oocytes expressing CAT1.	Arginine	100-108	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 L homeolog	Xenopus laevis	42-60
19707690-2	2009	Here we highlight a crucial role of a basic amino acid triad the entrance of the heme pocket in rHSA (Arg-114, His-146, Lys-190) for O(2) and CO binding to the prosthetic Fe(2+)PP group.	Arginine	102-105	CD24 molecule	Rattus norvegicus	96-100
12751792-3	2003	This arginine-rich N-terminus of snGPx, reminiscent of protamines, is encoded by an alternative exon located in the first intron of the PHGPx gene and is responsible for nuclear localisation and chromatin binding of snGPx [Pfeifer et al., FASEB J.	Arginine	5-13	glutathione peroxidase 4	Homo sapiens	33-38
12751792-3	2003	This arginine-rich N-terminus of snGPx, reminiscent of protamines, is encoded by an alternative exon located in the first intron of the PHGPx gene and is responsible for nuclear localisation and chromatin binding of snGPx [Pfeifer et al., FASEB J.	Arginine	5-13	glutathione peroxidase 4	Homo sapiens	136-141
12751792-3	2003	This arginine-rich N-terminus of snGPx, reminiscent of protamines, is encoded by an alternative exon located in the first intron of the PHGPx gene and is responsible for nuclear localisation and chromatin binding of snGPx [Pfeifer et al., FASEB J.	Arginine	5-13	glutathione peroxidase 4	Homo sapiens	216-221
12694184-4	2003	ICAM-4 lacks such a residue, which is replaced by an arginine.	Arginine	53-61	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	0-6
19533750-6	2009	ASS1 silencing conferred selective resistance to platinum-based drugs and conferred arginine auxotrophy and sensitivity to arginine deprivation.	Arginine	84-92	argininosuccinate synthase 1	Homo sapiens	0-4
19533750-6	2009	ASS1 silencing conferred selective resistance to platinum-based drugs and conferred arginine auxotrophy and sensitivity to arginine deprivation.	Arginine	123-131	argininosuccinate synthase 1	Homo sapiens	0-4
19533750-10	2009	The collateral sensitivity of cells lacking endogenous ASS1 to arginine depletion suggests novel therapeutic strategies for the management of relapsed ovarian cancer.	Arginine	63-71	argininosuccinate synthase 1	Homo sapiens	55-59
12665476-4	2003	After 1 h ischemia of bilateral kidneys plus 3, 6, or 12 h reperfusion, we first revealed that LOX-1 mRNA expression was increased in renal cortex and medulla at 6 h after reperfusion, which was decreased by L-arginine supplement.	Arginine	208-218	oxidized low density lipoprotein receptor 1	Rattus norvegicus	95-100
19578119-6	2009	We found that mutating two Arg residues at positions 36 and 37 in the C-domain of IGF-1 to Glu (the R36E/R37E mutation) effectively reduced integrin binding.	Arginine	27-30	insulin-like growth factor I	Cricetulus griseus	82-87
12665476-8	2003	These results disclosed for the first time that a deficiency in L-arginine by ischemia reperfusion causes uncoupling of constitutive NOS, which induces inducible NOS and LOX-1, implying why L-arginine is effective for stroke or transplantation in preventing atherosclerotic progress.	Arginine	64-74	oxidized low density lipoprotein receptor 1	Rattus norvegicus	170-175
12665476-8	2003	These results disclosed for the first time that a deficiency in L-arginine by ischemia reperfusion causes uncoupling of constitutive NOS, which induces inducible NOS and LOX-1, implying why L-arginine is effective for stroke or transplantation in preventing atherosclerotic progress.	Arginine	190-200	oxidized low density lipoprotein receptor 1	Rattus norvegicus	170-175
12673280-8	2003	We detected two disease-associated mutations in patients with Robin sequence, an Arg to stop codon mutation in COL11A2 and a splicing mutation in COL11A1.	Arginine	81-84	collagen type XI alpha 1 chain	Homo sapiens	146-153
19592491-4	2009	Here we show that SRPK2, a protein kinase specific for the serine/arginine (SR) family of splicing factors, triggers cell cycle progression in neurons and induces apoptosis through regulation of nuclear cyclin D1.	Arginine	66-74	SRSF protein kinase 2	Homo sapiens	18-23
12564981-6	2003	In this review, we specifically focus on arginine-containing MTS, and their properties, characteristics, in vitro and in vivo applications are discussed in detail.	Arginine	41-49	translocase of inner mitochondrial membrane 8A	Homo sapiens	61-64
12441350-9	2003	Therefore, we conclude that although the three intracellular loops of EDNRB may be involved in coupling to G proteins, residues Met(128)-Arg(129)-Asn(130) in the first intracellular loop are specifically required for activation of Galpha(13).	Arginine	137-140	guanine nucleotide binding protein, alpha 13	Mus musculus	231-241
19564338-7	2009	Mass spectrometric analysis revealed that ADAM10, but not ADAM9, cleaved PrP between Gly(228) and Arg(229), three residues away from the site of glycosylphosphatidylinositol anchor attachment.	Arginine	98-101	a disintegrin and metallopeptidase domain 10	Mus musculus	42-48
12522122-0	2003	Rapid stimulation of L-arginine transport by D-glucose involves p42/44(mapk) and nitric oxide in human umbilical vein endothelium.	Arginine	21-31	cyclin dependent kinase 20	Homo sapiens	64-67
19651599-4	2009	Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4"s small C-terminal domain.	Arginine	0-3	component of oligomeric golgi complex 4	Homo sapiens	102-106
12522122-6	2003	Our findings demonstrate that the human fetal endothelial L-arginine/NO signaling pathway is rapidly activated by elevated D-glucose via NO and p42/44(mapk).	Arginine	58-68	cyclin dependent kinase 20	Homo sapiens	144-147
19394797-6	2009	DNA samples of 137 OSCC patients were analyzed for SNP genotypes Arg/Arg, Arg/Gln and Gln/Gln in the coding region (exon 8) of ECRG1.	Arginine	65-68	transmembrane serine protease 11A	Homo sapiens	127-132
14658850-6	2003	The affected sheep was homozygous for the allele PrP(ARQ) (ARQ/ARQ) coding for alanine (A), arginine (R) and glutamine (Q) at three most relevant codons (136, 154 and 171, respectively).	Arginine	92-100	major prion protein	Ovis aries	49-52
12693980-5	2003	The enzyme cleaves arginine from enkephalin-Leu5-Arg6 and dansyl-Phe-Leu-Arg to form enkephalin-Leu5 and dansyl-Phe-Leu, respectively, and very slowly cleaves leucine from carbobenzoxy-Gly-Leu.	Arginine	19-27	tripartite motif containing 13	Homo sapiens	44-48
12693980-5	2003	The enzyme cleaves arginine from enkephalin-Leu5-Arg6 and dansyl-Phe-Leu-Arg to form enkephalin-Leu5 and dansyl-Phe-Leu, respectively, and very slowly cleaves leucine from carbobenzoxy-Gly-Leu.	Arginine	19-27	tripartite motif containing 13	Homo sapiens	96-100
12589771-4	2003	Arginine can be regenerated from citrulline, another product of the NOS reaction, by argininosuccinate synthetase and argininosuccinate lyase, forming the citrulline-NO cycle.	Arginine	0-8	argininosuccinate lyase	Rattus norvegicus	118-141
15080264-2	2003	We studied whether the enzyme peptidylarginine deiminase (PAD), responsible for the post-translational modification of peptide-bound arginine residues to citrulline, constitutes an antigen for patients with RA.	Arginine	38-46	peptidyl arginine deiminase 4	Homo sapiens	58-61
12488509-6	2002	In vitro experiments have indicated that ART-1, an enzyme also present in the airway epithelium, specifically modifies Arg(14) of the HNP-1, causing the loss of the peptide"s antimicrobial and cytotoxic activity, while preserving its chemotactic activity.	Arginine	119-122	HNP1	Homo sapiens	134-139
12244093-4	2002	This is the result of the large number of lysine and arginine residues scattered over the entire surface of hGIIA, which cause the enzyme to form a supramolecular aggregate with multiple vesicles.	Arginine	53-61	glucosidase II alpha subunit	Homo sapiens	108-113
12244096-2	2002	The SMN protein is important in small nuclear ribonucleoprotein (snRNP) assembly and interacts with snRNP proteins via arginine/glycine-rich domains.	Arginine	119-127	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	100-105
12450399-7	2002	N-terminal sequence and mass spectrometry analysis of trypsin-digested TSRs indicated that the RFK linker sequence between P1 and P2 is readily proteolyzed and the conserved arginines are solvent accessible.	Arginine	174-183	riboflavin kinase	Homo sapiens	95-98
12490409-3	2002	The expression of EBV early antigen (EA), immediate-early BZLF1 mRNA and the protein ZEBRA, and production of infectious virus were reduced by L-Arg supplementation in a dose-dependent manner.	Arginine	143-148	protein Zta	Human gammaherpesvirus 4	58-63
12446365-7	2002	A different type of FBN1 mutation presents in this group of patients, compared with MFS, with arginine to cysteine substitutions appearing frequently.	Arginine	94-102	fibrillin 1	Homo sapiens	20-24
12493091-11	2002	In vivo inhibition of iNOS or ODC decreased ROS production induced by GLN and ARG.	Arginine	78-81	ornithine decarboxylase 1	Rattus norvegicus	30-33
12414939-0	2002	Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation.	Arginine	55-63	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	186-189
12414939-1	2002	The herpes simplex virus Us11 gene product inhibits activation of the cellular PKR kinase and associates with a limited number of unrelated viral and cellular RNA molecules via a carboxyl-terminal 68-amino-acid segment rich in arginine and proline.	Arginine	227-235	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	79-82
12226095-3	2002	MG modification of Hsp27 selectively occurs at Arg-188 to form argpyrimidine, and mutation in the residue represses the formation of a large oligomer.	Arginine	47-50	heat shock protein family B (small) member 1	Homo sapiens	19-24
12427973-4	2002	The proangiogenic N-terminal fragment mini-TyrRS has IL-8-like cytokine activity that, like other CXC cytokines, depends on a Glu-Leu-Arg motif.	Arginine	134-137	tyrosyl-tRNA synthetase 1	Homo sapiens	43-48
12429851-0	2002	Early stages of energy transduction by myosin: roles of Arg in switch I, of Glu in switch II, and of the salt-bridge between them.	Arginine	56-59	myosin heavy chain 14	Homo sapiens	39-45
12429851-7	2002	From the behavior of recombinant myosin systems in which Arg-247 and Glu-470 were substituted in several ways, we draw the conclusions that (i) the force between Arg-247 and gamma-phosphate of ATP may assist in closing the cleft, and incidentally in signaling to the remote Trp, and (ii) in catalysis, Glu-470 is involved in holding the lytic H(2)O (w(1)).	Arginine	57-60	myosin heavy chain 14	Homo sapiens	33-39
12429851-7	2002	From the behavior of recombinant myosin systems in which Arg-247 and Glu-470 were substituted in several ways, we draw the conclusions that (i) the force between Arg-247 and gamma-phosphate of ATP may assist in closing the cleft, and incidentally in signaling to the remote Trp, and (ii) in catalysis, Glu-470 is involved in holding the lytic H(2)O (w(1)).	Arginine	162-165	myosin heavy chain 14	Homo sapiens	33-39
12376561-6	2002	The actions of IGFBP-3 and -5 on cell attachment to ECM were lost in the presence of a soluble Arg-Gly-Asp (RGD)-containing fibronectin fragment.	Arginine	95-98	insulin like growth factor binding protein 3	Homo sapiens	15-29
12383116-8	2002	Detailed structure-activity relationship investigations revealed that the determinants within this sequence are residues Arg(155), Leu(157) and Phe(159) and more completely define the composition of the cyclin-binding motif.	Arginine	121-124	proliferating cell nuclear antigen	Homo sapiens	203-209
12429874-0	2002	Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans.	Arginine	45-53	leptin	Homo sapiens	20-26
12429874-1	2002	OBJECTIVE: We examined short-term effects of arginine infusion on plasma leptin in diabetic and healthy subjects.	Arginine	45-53	leptin	Homo sapiens	73-79
12429874-4	2002	During arginine infusion, peak plasma insulin was lower in DM1 than in DM2 (p &lt; 0.05) and CON (p &lt; 0.01).	Arginine	7-15	immunoglobulin heavy diversity 1-7	Homo sapiens	59-62
12429874-9	2002	DISCUSSION: Arginine infusion transiently decreased plasma leptin concentrations both in insulin-deficient and hyperinsulinemic diabetic patients, indicating a direct inhibitory effect of the amino acid but not of insulin or FFAs.	Arginine	12-20	leptin	Homo sapiens	59-65
12487923-8	2002	The expression of ERK-1 in brain was much higher in CHM group than in L-arg group (P &lt; 0.05), the expression of MKP-1 was almost the same (P &gt; 0.05); Both of them in liver were higher in CHM group than in L-arg group (P &lt; 0.01).	Arginine	211-216	dual specificity phosphatase 1	Rattus norvegicus	115-120
12393059-0	2002	[Met5]enkephalin-Arg-Gly-Leu-induced antinociception is greatly increased by peptidase inhibitors.	Arginine	17-20	proenkephalin	Rattus norvegicus	6-16
12369826-5	2002	However, a loss of approximately one ionic interaction on mutation to Arg indicates that the optimal configuration of the network of basic residues of antithrombin that together interact with the pentasaccharide requires a Lys in position 114.	Arginine	70-73	serpin family C member 1	Homo sapiens	151-163
12369826-10	2002	This requirement is most likely due to the ability of Arg to interact with other residues of antithrombin, primarily, Glu414 and Thr44, in a manner that appropriately positions the Arg side chain for keeping the pentasaccharide anchored to the activated state of the inhibitor.	Arginine	54-57	serpin family C member 1	Homo sapiens	93-105
12369826-10	2002	This requirement is most likely due to the ability of Arg to interact with other residues of antithrombin, primarily, Glu414 and Thr44, in a manner that appropriately positions the Arg side chain for keeping the pentasaccharide anchored to the activated state of the inhibitor.	Arginine	181-184	serpin family C member 1	Homo sapiens	93-105
12237128-4	2002	All GFP-ZHX1 fusion proteins including an arginine-rich region that corresponds to the amino acid sequence between 734 and 768 were localized in the nuclei.	Arginine	42-50	zinc fingers and homeoboxes 1	Homo sapiens	8-12
12239560-4	2002	The GTPase-activating protein (GAP) activity of Sec23 involves an arginine side chain inserted into the Sar1 active site.	Arginine	66-74	GTPase-activating protein SEC23	Saccharomyces cerevisiae S288C	48-53
12234472-0	2002	Detection of polymorphisms at exons 3 (Tyr113--&gt;His) and 4 (His139--&gt;Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis.	Arginine	75-78	epoxide hydrolase 1	Homo sapiens	87-115
12213887-5	2002	The IRS-1 Gly(972)Arg allele frequencies were identical in whites and African-Americans [0.95 (Gly) and 0.05 (Arg)].	Arginine	18-21	insulin receptor substrate 1	Homo sapiens	4-9
12217421-11	2002	The arginine residue at position 7 is required for NmU-8 activity at either receptor while alanine substitution at position 5 selectively affects the potency and the efficacy at mNmU-R1.	Arginine	4-12	neuromedin U	Mus musculus	51-54
12217421-12	2002	These experiments validate the use of rodent models to characterize NmU function relative to humans and suggest that substitution at Arginine-5 of NmU-8 may provide a receptor selective peptide.	Arginine	133-141	neuromedin U	Mus musculus	147-150
12060666-4	2002	Lys-731 and Lys-788 are located in the NR interaction domain (NID), and their substitution by arginines impairs the ability of GRIP1 to colocalize with androgen receptor (AR) in nuclei.	Arginine	94-103	glutamate receptor interacting protein 1	Homo sapiens	127-132
19394797-6	2009	DNA samples of 137 OSCC patients were analyzed for SNP genotypes Arg/Arg, Arg/Gln and Gln/Gln in the coding region (exon 8) of ECRG1.	Arginine	69-72	transmembrane serine protease 11A	Homo sapiens	127-132
19394797-6	2009	DNA samples of 137 OSCC patients were analyzed for SNP genotypes Arg/Arg, Arg/Gln and Gln/Gln in the coding region (exon 8) of ECRG1.	Arginine	69-72	transmembrane serine protease 11A	Homo sapiens	127-132
19638477-3	2009	Based on a published high-resolution (2.89 A) tubulin structure, we predict that Arg-2 of alpha-tubulin forms hydrogen bonds with the GTPase domain of beta-tubulin, and structural modeling suggests that these contacts are interrupted in tor2.	Arginine	81-84	tubulin alpha-4 chain	Arabidopsis thaliana	237-241
19346356-6	2009	Strains defective in arginine degradation (Car1 and Car2) accumulated up to 4% (wt/wt) CGP, whereas strains defective in arginine synthesis (Arg1, Arg3, and Arg4) accumulated up to 15.3% (wt/wt) of CGP, which is more than twofold higher than the previously content reported in yeast and the highest content ever reported in eukaryotes.	Arginine	21-29	arginase	Saccharomyces cerevisiae S288C	43-47
19346356-6	2009	Strains defective in arginine degradation (Car1 and Car2) accumulated up to 4% (wt/wt) CGP, whereas strains defective in arginine synthesis (Arg1, Arg3, and Arg4) accumulated up to 15.3% (wt/wt) of CGP, which is more than twofold higher than the previously content reported in yeast and the highest content ever reported in eukaryotes.	Arginine	21-29	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	52-56
19289494-0	2009	A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation.	Arginine	56-64	protein arginine N-methyltransferase 1	Mus musculus	8-13
19289494-3	2009	Using the Cre/lox-conditional system, we show that the loss of PRMT1 in mouse embryonic fibroblasts (MEFs) leads to the loss of arginine methylation of substrates harboring a glycine-arginine rich motif, including Sam68 and MRE11.	Arginine	128-136	protein arginine N-methyltransferase 1	Mus musculus	63-68
19289494-3	2009	Using the Cre/lox-conditional system, we show that the loss of PRMT1 in mouse embryonic fibroblasts (MEFs) leads to the loss of arginine methylation of substrates harboring a glycine-arginine rich motif, including Sam68 and MRE11.	Arginine	183-191	protein arginine N-methyltransferase 1	Mus musculus	63-68
19465913-4	2009	Complex formation is promoted by the recognition of symmetrically dimethylated arginines at the N terminus of Mili by the tudor domains of Tdrd1.	Arginine	79-88	tudor domain containing 1	Mus musculus	139-144
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	tumor protein p53 inducible nuclear protein 1	Rattus norvegicus	310-332
19608021-9	2009	CONCLUSIONS: The Arg allele carriers of the Lys109Arg LEPR gene polymorphism were associated with an increased proinflammatory state and stress condition at baseline.	Arginine	17-20	leptin receptor	Homo sapiens	54-58
19090718-4	2009	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, mass spectrometry, and N-terminal sequence analyses show that KLK9 and 10 exhibit low hydrolytic activities towards all of the 15 pro-KLK sequences, while KLK15 exhibits significant activity towards both Arg- and Lys-containing KLK pro-sequences.	Arginine	263-266	kallikrein related peptidase 9	Homo sapiens	121-125
12124262-6	2002	The subsequent simulation on Arg-207-Ala (R207A) mutation of gelsolin indicated that this mutation facilitates the unbinding of the tail helix and that the contribution of the hydrogen bond between Arg-207 and Asp-744 to the binding is more than 50%, which offers a new clue for further mutagenesis study on the activation mechanism of gelsolin.	Arginine	29-32	gelsolin	Homo sapiens	61-69
12124262-6	2002	The subsequent simulation on Arg-207-Ala (R207A) mutation of gelsolin indicated that this mutation facilitates the unbinding of the tail helix and that the contribution of the hydrogen bond between Arg-207 and Asp-744 to the binding is more than 50%, which offers a new clue for further mutagenesis study on the activation mechanism of gelsolin.	Arginine	29-32	gelsolin	Homo sapiens	336-344
12124262-8	2002	Additionally, temperature also has a significant effect on the conformation of the arginine and arginine-related interactions, which revealed the molecular basis of the temperature dependence in gelsolin activation.	Arginine	83-91	gelsolin	Homo sapiens	195-203
12124262-8	2002	Additionally, temperature also has a significant effect on the conformation of the arginine and arginine-related interactions, which revealed the molecular basis of the temperature dependence in gelsolin activation.	Arginine	96-104	gelsolin	Homo sapiens	195-203
19118899-5	2009	Ubiquitylation of KPNA1 required the lysine/arginine-rich region spanning RAG1 amino acids 218-263 upstream of the RAG1 ubiquitin ligase domain, but RAG1 was still able to undergo auto-ubiquitylation in this region even in the presence of KPNA1.	Arginine	44-52	recombination activating 1	Homo sapiens	74-78
18789468-3	2009	Fibrillin-1 contains the Arg-Gly-Asp (RGD) motif, which may allow binding to RGD-recognizing integrins.	Arginine	25-28	fibrillin 1	Homo sapiens	0-11
19356679-2	2009	Recent evidence suggests that agmatine, the metabolite of arginine by arginine decarboxylase, exists in the mammalian brain and is a novel neurotransmitter.	Arginine	58-66	antizyme inhibitor 2	Homo sapiens	70-92
19428830-5	2009	Furthermore, substitution of the proline residues of indolicidin with arginine increased the synergistic adjuvant effect of the peptide, and induced significantly higher IgG1 and IgG2a titers and IFN-gamma secretion, as well as increased uptake by antigen presenting cells.	Arginine	70-78	immunoglobulin heavy variable V1-9	Mus musculus	179-184
19074424-0	2009	The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex.	Arginine	22-30	thrombomodulin	Homo sapiens	112-126
19218456-4	2009	Massively parallel sequencing of the entire 2.2-Mb interval identified 2 single-base substitutions, one in an intergenic region and a second causing replacement of a highly conserved cysteine with arginine (C193R) in the gene Megf8.	Arginine	197-205	multiple EGF-like-domains 8	Mus musculus	226-231
18814047-9	2009	For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07).	Arginine	134-137	serpin family B member 3	Homo sapiens	4-7
18814047-9	2009	For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07).	Arginine	138-141	serpin family B member 3	Homo sapiens	4-7
19514640-8	2009	Linkage analysis revealed that the Arg/Gln-Ser/Ser combination of genotypes of XRCC1 and hOGG1, respectively (not associated with a decreased activity of both genes) occurs more commonly in type 2 diabetic patients.	Arginine	35-38	8-oxoguanine DNA glycosylase	Homo sapiens	89-94
19068482-3	2009	By homology modeling, we identified two Glu residues (Glu-145 and Glu-172) in the second extracellular loop of FFAR1 that form putative interactions individually with two transmembrane Arg residues (Arg-183(5.39) and Arg-258(7.35)) to create two ionic locks.	Arginine	185-188	free fatty acid receptor 1	Homo sapiens	111-116
19068482-3	2009	By homology modeling, we identified two Glu residues (Glu-145 and Glu-172) in the second extracellular loop of FFAR1 that form putative interactions individually with two transmembrane Arg residues (Arg-183(5.39) and Arg-258(7.35)) to create two ionic locks.	Arginine	199-202	free fatty acid receptor 1	Homo sapiens	111-116
19068482-3	2009	By homology modeling, we identified two Glu residues (Glu-145 and Glu-172) in the second extracellular loop of FFAR1 that form putative interactions individually with two transmembrane Arg residues (Arg-183(5.39) and Arg-258(7.35)) to create two ionic locks.	Arginine	199-202	free fatty acid receptor 1	Homo sapiens	111-116
19068482-4	2009	Molecular dynamics simulations showed that binding of agonists to FFAR1 leads to breakage of these Glu-Arg interactions.	Arginine	103-106	free fatty acid receptor 1	Homo sapiens	66-71
18368465-1	2009	Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC).	Arginine	84-92	ornithine decarboxylase 1	Rattus norvegicus	124-147
18368465-1	2009	Polyamines are important for cell growth and proliferation and they are formed from arginine and ornithine via arginase and ornithine decarboxylase (ODC).	Arginine	84-92	ornithine decarboxylase 1	Rattus norvegicus	149-152
19143629-4	2009	Binding of Ca(2+) to EF3 (third EF-hand) enables the side chain of Arg(125), present in the loop connecting EF3 and EF4 (fourth EF-hand), to move sufficiently to make a primary hydrophobic pocket accessible to the critical PPYP (Pro-Pro-Tyr-Pro) motif in Alix, which partially overlaps with the GPP (Gly-Pro-Pro) motif for binding to Cep55 (centrosome protein of 55 kDa).	Arginine	67-70	programmed cell death 6 interacting protein	Homo sapiens	255-259
19011997-4	2009	We found a heterozygous CGG to CAG transition in codon 482 of exon 8 in the gene encoding lamin A/C (LMNA), which leads to an arginine to glutamine substitution (R482Q).	Arginine	126-134	lamin A/C	Homo sapiens	90-99
19011997-4	2009	We found a heterozygous CGG to CAG transition in codon 482 of exon 8 in the gene encoding lamin A/C (LMNA), which leads to an arginine to glutamine substitution (R482Q).	Arginine	126-134	lamin A/C	Homo sapiens	101-105
18957377-4	2009	Expression studies in Xenopus laevis on rabbit PepT1 that had undergone site-directed mutagenesis of a conserved arginine residue (arginine282 in transmembrane domain 7) to a glutamate revealed that this residue played a role in the coupling of proton and peptide transport and prevented the movement of non-coupled ions during the transporter cycle.	Arginine	113-121	solute carrier family 15 member 1	Oryctolagus cuniculus	47-52
19284685-1	2009	Selective breeding of sheep for arginine (R) at prion gene (PRNP) codon 171 confers resistance to classical scrapie.	Arginine	32-40	major prion protein	Ovis aries	60-64
19022677-3	2009	Various acidic heterocycles were introduced into a hydrophobic phenylcarborane (1-phenyl-1,12-dicarba-closo-dodecaborane) core structure to provide a moiety that could interact effectively with the critical basic arginine residue of the AR ligand binding domain.	Arginine	213-221	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	237-239
19152634-0	2009	The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.	Arginine	61-69	relaxin 3	Homo sapiens	77-86
19136629-9	2009	Our findings identify PRMT1 as a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.	Arginine	133-141	protein inhibitor of activated STAT 1	Homo sapiens	104-109
19004619-1	2009	Peptidylarginine deiminase (PAD, EC 3.5.3.15) enzyme catalyzes the conversion of arginine residues to citrulline residues in the presence of calcium ion, which is an elaborate post-translational modification on the target protein.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
18977358-0	2009	Protein kinase C mediated inhibition of endothelial L-arginine transport is mediated by MARCKS protein.	Arginine	52-62	myristoylated alanine rich protein kinase C substrate	Bos taurus	88-94
18977358-10	2009	Moreover antisense inhibition of MARCKS abolished the PMA effect on L-arginine transport.	Arginine	68-78	myristoylated alanine rich protein kinase C substrate	Bos taurus	33-39
18977358-11	2009	PKC dependent mechanisms regulate the transport of L-arginine, mediated via process involving MARCKS.	Arginine	51-61	myristoylated alanine rich protein kinase C substrate	Bos taurus	94-100
19348906-8	2009	Subsequently replacing ARG8(m) with mutated versions of cytochrome b results in arginine auxotrophy.	Arginine	80-88	acetylornithine transaminase	Saccharomyces cerevisiae S288C	23-27
19006321-5	2008	A set of important residues, which participate in the C1q epitopes for scFv, were identified: Lys(C170) for the scFv3(V) epitope and Arg(B108) and Arg(B109) for the scFv10(V) epitope.	Arginine	147-150	complement C1q A chain	Homo sapiens	54-57
18806759-4	2008	In this study, we identify the splicing factor SC35, a member of the Ser-Rich Arg (SR) proteins family, as a new transcriptional target of E2F1.	Arginine	78-81	E2F transcription factor 1	Homo sapiens	139-143
18477710-5	2008	The G&gt;A transition results in an exchange of an arginine for glutamine (p.Arg288Gln) in subdomain alpha5 of TOR1A.	Arginine	51-59	torsin family 1 member A	Homo sapiens	111-116
12214985-2	2002	Arginine supplementation alone caused a significant rise of plasma arginine, urea, and insulin concentrations, whereas glucagon concentrations tended to increase, but there were no significant group differences.	Arginine	0-8	insulin	Bos taurus	87-94
18477710-6	2008	Several findings point to a potentially pathogenic role of the sequence change in the patient: The base change is absent in 1000 control chromosomes; an Arg at position 288 of TOR1A has been conserved throughout vertebrate evolution, indicating an important role of Arg288 in TOR1A function; functional studies demonstrate enlarged perinuclear space in HEK293 cells overexpressing TOR1A with the p.Arg288Gln mutation.	Arginine	153-156	torsin family 1 member A	Homo sapiens	176-181
18773938-6	2008	Furthermore, we demonstrated that Btg2, one of the PRMT1 binding partner, depletion down-regulated arginine methylation in the nucleus and inhibited neurite outgrowth.	Arginine	99-107	protein arginine N-methyltransferase 1	Mus musculus	51-56
12372699-5	2002	This effect of BK(1-9) (10(-6) M) was mimicked by the B2 agonist [Phe(8)(CH(2)NH)Arg(9)]-bradykinin (10(-5) M) and blocked by the selective B2-receptor antagonist HOE140 (10(-5) M).	Arginine	81-84	bradykinin receptor B2	Homo sapiens	15-21
18773938-7	2008	These results indicate that protein arginine methylation by PRMT1 in the nucleus is an important step in neuritogenesis.	Arginine	36-44	protein arginine N-methyltransferase 1	Mus musculus	60-65
11986319-2	2002	In this study, we identified His(308) and Arg(277) residues as essential determinants for the donor substrate (UDP-glucuronic acid) selectivity of the human GlcAT-I.	Arginine	42-45	beta-1,3-glucuronyltransferase 3	Homo sapiens	157-164
18818404-13	2008	L-Arginine reduced cardiomyocyte shortening further in ISCH-AW (to 2.8+/-0.2%) and ISCH-PW (3.4+/-0.4% versus 5.4+/-0.4%) but not in SHAM or in ISCH+iNOS-Inhib; intracellular [Ca(2+)] remained unchanged.	Arginine	0-10	LOC396821	Sus scrofa	149-153
11986319-8	2002	Furthermore, the arginine-directed reagent 2,3-butanedione irreversibly inhibited GlcAT-I, which was effectively protected against inactivation by UDP-glucuronic acid but not by UDP-glucose.	Arginine	17-25	beta-1,3-glucuronyltransferase 3	Homo sapiens	82-89
11986319-10	2002	Our results are consistent with crucial interactions between the His(308) and Arg(277) residues and the glucuronic acid moiety that governs the specificity of GlcAT-I toward the nucleotide sugar donor substrate.	Arginine	78-81	beta-1,3-glucuronyltransferase 3	Homo sapiens	159-166
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	57-60	latent transforming growth factor beta binding protein 1	Homo sapiens	83-91
11971909-0	2002	Elimination of P1 arginine 393 interaction with underlying glutamic acid 255 partially activates antithrombin III for thrombin inhibition but not factor Xa inhibition.	Arginine	18-26	serpin family C member 1	Homo sapiens	97-113
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	61-64	latent transforming growth factor beta binding protein 1	Homo sapiens	83-91
12144927-4	2002	One of these engineered pores, P(RR-2), provides a ring of fourteen arginines that project into the lumen of the transmembrane barrel.	Arginine	68-77	nectin cell adhesion molecule 2	Homo sapiens	31-37
18058229-6	2008	However, combined analysis of the SNP"s showed that p53 (Arg/Arg and Arg/Pro) with TGFbeta1 (Pro/Pro and Leu/Pro) were associated with greater than 2 fold increased risk for breast cancer in Univariate (P=0.01) and Multivariate (P=0.003) analysis.	Arginine	61-64	latent transforming growth factor beta binding protein 1	Homo sapiens	83-91
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Arginine	129-132	sphingosine-1-phosphate receptor 1	Mus musculus	111-114
12075467-10	2002	The inhibitory action of L-Arg was abolished after pretreatment with antisense oligoneucleotide against MKP-1.	Arginine	25-30	dual specificity phosphatase 1	Rattus norvegicus	104-109
18708635-1	2008	Strong evidence exists for interactions of zwitterionic phosphate and amine groups in sphingosine-1 phosphate (S1P) to conserved Arg and Glu residues present at the extracellular face of the third transmembrane domain of S1P receptors.	Arginine	129-132	sphingosine-1-phosphate receptor 1	Mus musculus	221-224
12071959-6	2002	Furthermore, cotransfection of the FcR gamma-chain and two mutant versions of GPVI shows that the transmembrane arginine and cytoplasmic tail of GPVI are necessary for association with the FcR gamma-chain.	Arginine	112-120	glycoprotein VI platelet	Homo sapiens	78-82
18452209-13	2008	Residues from this helix interact with an Arg residue in Bad and Bim peptides.	Arginine	42-45	BCL2 like 11	Homo sapiens	65-68
12022882-6	2002	The reactivities of Arg(143) and Lys(147) mutants were improved approximately 2-fold with antithrombin in the absence but not in the presence of heparin cofactors.	Arginine	20-23	serpin family C member 1	Homo sapiens	90-102
12022882-7	2002	On the other hand, the pentasaccharide-catalyzed reactivity of antithrombin with the Arg(150) mutant was impaired by an order of magnitude.	Arginine	85-88	serpin family C member 1	Homo sapiens	63-75
12022882-8	2002	These results suggest that Arg(150) of the autolysis loop may specifically interact with the activated conformation of antithrombin.	Arginine	27-30	serpin family C member 1	Homo sapiens	119-131
18640142-7	2008	RESULTS: Subjects carrying the p21 Arg/Arg genotype had an increased UC risk (age and gender adjusted OR=1.53; 95% CI, 1.02-2.29).	Arginine	35-38	H3 histone pseudogene 16	Homo sapiens	31-34
11994446-4	2002	Deletion of the C-terminal arginine-rich domain of HBcAg generates HBcAg-144 or HBcAg-149 particles (in which &gt;98% of RNA binding is lost) that prime Th2-biased immunity.	Arginine	27-35	heart and neural crest derivatives expressed 2	Mus musculus	153-156
18640142-7	2008	RESULTS: Subjects carrying the p21 Arg/Arg genotype had an increased UC risk (age and gender adjusted OR=1.53; 95% CI, 1.02-2.29).	Arginine	39-42	H3 histone pseudogene 16	Homo sapiens	31-34
18674532-7	2008	The l-arginine-induced flow increase was reduced by prior administration of NG-nitro-arginine methyl ester (l-NAME, a non-specific NO synthase inhibitor), 7-nitroindazole (7-NI, a relatively selective neuronal NO synthase inhibitor), d-2-amino-5-phosphonopentanoate (d-AP5, a competitive NMDA receptor antagonist), or glutamate diethylester (GDEE, a competitive AMPA receptor antagonist).	Arginine	4-14	adaptor related protein complex 5 subunit beta 1	Homo sapiens	269-272
11900957-2	2002	However, arginase is an other enzyme able to metabolize the substrate L-arginine, and the two enzymes are alternatively regulated by Th1 and Th2 cytokines in murine macrophages.	Arginine	70-80	heart and neural crest derivatives expressed 2	Mus musculus	141-144
12044965-3	2002	In this study we investigated the impact of aging on the regulation, at the gene level, of the various enzymes that synthesize L-arginine in the kidney (argininosuccinate synthetase and argininosuccinate lyase) and citrulline, the precursor of L-arginine made in the small intestine (phosphate-dependent glutaminase, carbamyl phosphate synthetase-1 and ornithine transcarbamylase).	Arginine	127-137	argininosuccinate lyase	Rattus norvegicus	186-209
11997094-6	2002	Citrin, ASS, CPS and Ornt1 showed similar patterns of developmental changes in the liver and small intestine, where they play a role in urea and arginine synthesis.	Arginine	145-153	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	0-6
11997094-9	2002	All these results suggest that citrin as AGC plays a role in urea synthesis as well as many fundamental metabolic pathways in the liver, and shares metabolic functions with aralar1 in other tissues, and that Ornt1 is an important component in urea synthesis in the liver and in arginine synthesis in the small intestine during the neonatal period.	Arginine	278-286	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	Mus musculus	31-37
11751914-3	2002	Arg-14 and Arg-17, on the WW domain of Pin1, are thought to be important for the binding of Group IV ligands that have (Ser(P)/Thr(P))-Pro sequences.	Arginine	0-3	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	39-43
11751914-3	2002	Arg-14 and Arg-17, on the WW domain of Pin1, are thought to be important for the binding of Group IV ligands that have (Ser(P)/Thr(P))-Pro sequences.	Arginine	11-14	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	39-43
11779864-0	2002	Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p.	Arginine	89-97	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	114-119
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	23-26	endothelin converting enzyme 1	Homo sapiens	35-40
11831855-9	2002	The data indicate that Arg(133) of ECE-1, which corresponds to Arg(102) of neprilysin that has been identified as an active-site residue of neprilysin involved in binding to the free carboxylate of some substrate peptides, may not play the same role.	Arginine	63-66	endothelin converting enzyme 1	Homo sapiens	35-40
11831855-10	2002	However, the low activity observed for an ECE-1 Arg(726) mutant is consistent with a role for this arginine residue in the binding of substrates, a role which has been ascribed to arginine residues in both thermolysin (Arg(203)) and neprilysin (Arg(717)).	Arginine	48-51	endothelin converting enzyme 1	Homo sapiens	42-47
11831855-10	2002	However, the low activity observed for an ECE-1 Arg(726) mutant is consistent with a role for this arginine residue in the binding of substrates, a role which has been ascribed to arginine residues in both thermolysin (Arg(203)) and neprilysin (Arg(717)).	Arginine	99-107	endothelin converting enzyme 1	Homo sapiens	42-47
11831855-10	2002	However, the low activity observed for an ECE-1 Arg(726) mutant is consistent with a role for this arginine residue in the binding of substrates, a role which has been ascribed to arginine residues in both thermolysin (Arg(203)) and neprilysin (Arg(717)).	Arginine	180-188	endothelin converting enzyme 1	Homo sapiens	42-47
11831855-10	2002	However, the low activity observed for an ECE-1 Arg(726) mutant is consistent with a role for this arginine residue in the binding of substrates, a role which has been ascribed to arginine residues in both thermolysin (Arg(203)) and neprilysin (Arg(717)).	Arginine	219-222	endothelin converting enzyme 1	Homo sapiens	42-47
11831855-10	2002	However, the low activity observed for an ECE-1 Arg(726) mutant is consistent with a role for this arginine residue in the binding of substrates, a role which has been ascribed to arginine residues in both thermolysin (Arg(203)) and neprilysin (Arg(717)).	Arginine	219-222	endothelin converting enzyme 1	Homo sapiens	42-47
11903230-5	2002	RESULTS: We identified a heterozygous arginine to histidine p63 mutation, R279H, in all three affected individuals.	Arginine	38-46	tumor protein p63	Homo sapiens	60-63
11834428-4	2002	RESULTS: The combined administration of GHRH-Ant distinctly inhibited the arginine- and insulin-induced GH release.	Arginine	74-82	solute carrier family 25 member 6	Homo sapiens	45-48
11834428-6	2002	These responses to arginine and insulin were also completely inhibited by the combined administration of GHRH-Ant.	Arginine	19-27	solute carrier family 25 member 6	Homo sapiens	110-113
11802715-5	2002	We demonstrate that recombinant MSP exhibits a broad specificity for cleavage after arginine but not lysine residues, with kinetic characteristics intermediate between trypsin and pancreatic kallikrein.	Arginine	84-92	transmembrane serine protease 13	Homo sapiens	32-35
11802715-7	2002	MSP may be regulated in part by autolysis, since the active protein is readily inactivated through autolysis at specific internal arginine positions.	Arginine	130-138	transmembrane serine protease 13	Homo sapiens	0-3
11706008-10	2002	Alanine mutations of membrane-proximal basic amino acid residues in the cytoplasmic domain of L-selectin identified arginine 357 as a critical residue for both ezrin and moesin interaction.	Arginine	116-124	selectin L	Homo sapiens	94-104
11706008-10	2002	Alanine mutations of membrane-proximal basic amino acid residues in the cytoplasmic domain of L-selectin identified arginine 357 as a critical residue for both ezrin and moesin interaction.	Arginine	116-124	ezrin	Homo sapiens	160-165
11777982-4	2002	In this study, we demonstrate that stimulation of murine peritoneal macrophages with MSP results in the RON-dependent up-regulation of arginase, an enzyme associated with alternative activation that competes with iNOS for the substrate L-arginine, the products of which are involved in cell proliferation and matrix synthesis.	Arginine	236-246	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	Mus musculus	104-107
16233323-4	2002	When grown on arginine as the sole nitrogen source, the put2 disruptant showed a significant decrease in cell viability after freezing despite the high proline and arginine contents.	Arginine	14-22	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	56-60
16233323-4	2002	When grown on arginine as the sole nitrogen source, the put2 disruptant showed a significant decrease in cell viability after freezing despite the high proline and arginine contents.	Arginine	164-172	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	56-60
12658790-5	2002	The results showed that L-arginine with concentration &gt; or = 1 x 10(-4) mol/L could induce apoptosis of the TM cells and inhibit the proliferation of TM cells through increasing the NO levels, down-regulating bcl-2 mRNA expression and up-regulating bax mRNA expression; L-NAME with concentration &gt; or = 1 x 10(-5) mol/L could induce the proliferation of the TM cells through suppressing the production of NO.	Arginine	24-34	BCL2 apoptosis regulator	Bos taurus	212-217
12658790-5	2002	The results showed that L-arginine with concentration &gt; or = 1 x 10(-4) mol/L could induce apoptosis of the TM cells and inhibit the proliferation of TM cells through increasing the NO levels, down-regulating bcl-2 mRNA expression and up-regulating bax mRNA expression; L-NAME with concentration &gt; or = 1 x 10(-5) mol/L could induce the proliferation of the TM cells through suppressing the production of NO.	Arginine	24-34	BCL2 associated X, apoptosis regulator	Bos taurus	252-255
11604408-8	2001	Based on the presence of Arg and Ser at the reactive center of the RSL, SERPINB12 appeared to be an inhibitor of trypsin-like serine proteinases.	Arginine	25-28	serpin family B member 12	Homo sapiens	72-81
11802521-7	2001	The mutation causing the disease was located at ALK-1 codon 411, causing an arginine to glutamine substitution.	Arginine	76-84	activin A receptor like type 1	Homo sapiens	48-53
11723245-0	2001	An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors.	Arginine	3-11	purinergic receptor P2Y11	Homo sapiens	196-201
11723245-6	2001	Mutational analysis revealed that the change of Arg-265, which is located at the juxtaposition of transmembrane domain 6 and the third extracellular loop in the hP2Y11 receptor, to glutamine in the cP2Y11 receptor is at least partly responsible for the diphosphate selectivity but not the increased sensitivity to 2-thioether-substituted adenine nucleotides at the canine receptor.	Arginine	48-51	purinergic receptor P2Y11	Homo sapiens	161-167
11723245-7	2001	These results imply a key role for a positively charged arginine residue in contributing to the recognition of extracellular nucleotides by the P2Y11 receptor and perhaps other P2Y receptors.	Arginine	56-64	purinergic receptor P2Y11	Homo sapiens	144-149
11930230-3	2001	The endothelium dependent relaxation response to 10(-6) mol/L ACh was restored by L arginine in the TNF-alpha group which had been incubated for 7 h, but was not affected by AG in each group, while the contractile response to 10(-6) mol/L PE increased significantly in the TNF-alpha group.	Arginine	82-92	tumor necrosis factor	Oryctolagus cuniculus	100-109
11559698-7	2001	The participation of Glu(350), Asp(355), and Arg(356) provides a molecular explanation for the differential exposure of this epitope in the different conformations of PAI-1 and for the effect of these antibodies on the kinetics of the formation of the initial PAI-1-proteinase complexes.	Arginine	45-48	serpin family E member 1	Homo sapiens	167-172
11597769-2	2001	These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598.	Arginine	82-90	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	41-44
11597769-2	2001	These features are lost if the principal NR1 subunit carries an asparagine (N) to arginine (R) substitution in a critical channel site at NR1 position 598.	Arginine	82-90	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	138-141
11574067-8	2001	In addition, the mutation of Arg(63) to either alanine or glutamine increased the apparent K(m) values for porcine cytochrome b5 (Pb5), while changing Arg(63) to lysine did not.	Arginine	29-32	cytochrome b5 type A	Homo sapiens	115-128
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Arginine	185-193	replication factor C subunit 4	Saccharomyces cerevisiae S288C	158-162
11522702-0	2001	Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.	Arginine	9-12	adrenoceptor beta 3	Homo sapiens	71-98
11522702-0	2001	Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.	Arginine	13-16	adrenoceptor beta 3	Homo sapiens	71-98
11522702-0	2001	Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.	Arginine	13-16	adrenoceptor beta 3	Homo sapiens	71-98
18660502-5	2008	A novel upstream RhoA mediator was shown to be ABL2, also known as ARG, a membrane-anchored nonreceptor tyrosine kinase.	Arginine	67-70	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	47-51
11522702-11	2001	CONCLUSIONS: Genotype Arg/Arg, but not Trp/Arg, of the beta(3)-adrenergic receptor was associated with both obesity and type 2 diabetes in a large Japanese sample.	Arginine	22-25	adrenoceptor beta 3	Homo sapiens	55-82
11522702-11	2001	CONCLUSIONS: Genotype Arg/Arg, but not Trp/Arg, of the beta(3)-adrenergic receptor was associated with both obesity and type 2 diabetes in a large Japanese sample.	Arginine	26-29	adrenoceptor beta 3	Homo sapiens	55-82
11522702-11	2001	CONCLUSIONS: Genotype Arg/Arg, but not Trp/Arg, of the beta(3)-adrenergic receptor was associated with both obesity and type 2 diabetes in a large Japanese sample.	Arginine	26-29	adrenoceptor beta 3	Homo sapiens	55-82
18660502-10	2008	Together, these results suggested that ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity.	Arginine	44-47	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	39-43
18660502-10	2008	Together, these results suggested that ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity.	Arginine	44-47	semaphorin 3F	Homo sapiens	71-77
18662981-7	2008	Fine structure mapping identified several Lys and Arg residues in this region that form salt bridges with Asp and Glu residues in NEIL1.	Arginine	50-53	nei like DNA glycosylase 1	Homo sapiens	130-135
18689498-7	2008	In obese mice, a 2.5-fold increase in leptin concentration coincided with 100% increase in eNOS and about 30% decrease in intracellular L-arginine.	Arginine	136-146	leptin	Mus musculus	38-44
11700920-12	2001	The liver MPO (as a measurement of neutrophil migration into the liver parenchyma) was significantly decreased only in the SNP and L-arginine groups (p &lt; .05) but not in the iNOS group (p &gt; .5).	Arginine	131-141	myeloperoxidase	Rattus norvegicus	10-13
18689498-10	2008	In obesity, leptin increases eNOS expression and decreases intracellular l-arginine, resulting in eNOS an uncoupling and depletion of endothelial NO and an increase of cytotoxic ONOO(-).	Arginine	73-83	leptin	Mus musculus	12-18
11502871-15	2001	CONCLUSION: This work demonstrates that ANP inhibits LPS-induced L-arginine uptake via its guanylate cyclase-coupled A-receptor.	Arginine	65-75	natriuretic peptide type A	Mus musculus	40-43
18753262-1	2008	Mini-tyrosyl-tRNA synthetase (mini-TyrRS), the N-terminal domain of tyrosyl-tRNA synthetase, is a recently identified protein released by endothelial cells that exhibits angiogenic and leukocyte chemoattractant, ELR-motif (Glu-Leu-Arg)-dependent activities in vitro.	Arginine	231-234	tyrosyl-tRNA synthetase	Mus musculus	5-28
11454802-8	2001	A lower dose of arginine (3.0 g/kg) induced less pancreatitis but a larger increase in HSP70 and HSP27 expression and phosphorylation of HSP27.	Arginine	16-24	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	87-92
18753262-1	2008	Mini-tyrosyl-tRNA synthetase (mini-TyrRS), the N-terminal domain of tyrosyl-tRNA synthetase, is a recently identified protein released by endothelial cells that exhibits angiogenic and leukocyte chemoattractant, ELR-motif (Glu-Leu-Arg)-dependent activities in vitro.	Arginine	231-234	tyrosyl-tRNA synthetase	Mus musculus	35-40
18753262-1	2008	Mini-tyrosyl-tRNA synthetase (mini-TyrRS), the N-terminal domain of tyrosyl-tRNA synthetase, is a recently identified protein released by endothelial cells that exhibits angiogenic and leukocyte chemoattractant, ELR-motif (Glu-Leu-Arg)-dependent activities in vitro.	Arginine	231-234	tyrosyl-tRNA synthetase	Mus musculus	68-91
11399059-9	2001	The IEC adhesion to FN was inhibited by specific antibody against the FN receptor (VLA-5), as well as competitive Arg-Gly-Asp (RGD) peptide.	Arginine	114-117	fibronectin 1	Mus musculus	20-22
18616983-0	2008	Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.	Arginine	31-39	F-box protein 32	Mus musculus	49-54
11410740-7	2001	IFN-gamma in combination with TNF-alpha induced NO production with an enhancement in CAT-2B mRNA expression and L-arginine transport, whereas L-arginine transport and NO production were suppressed by coincubated ethanol.	Arginine	112-122	interferon gamma	Rattus norvegicus	0-9
11410740-7	2001	IFN-gamma in combination with TNF-alpha induced NO production with an enhancement in CAT-2B mRNA expression and L-arginine transport, whereas L-arginine transport and NO production were suppressed by coincubated ethanol.	Arginine	142-152	interferon gamma	Rattus norvegicus	0-9
18616983-0	2008	Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.	Arginine	31-39	F-box protein 32	Mus musculus	55-64
18616983-0	2008	Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.	Arginine	31-39	mechanistic target of rapamycin kinase	Mus musculus	85-89
18616983-3	2008	In the present study, we examined the direct effect of 5 mM amino acids (leucine, isoleucine, valine, glutamine and arginine) on atrogin-1 and MuRF1 levels in C2C12 muscle cells and the involved intracellular signal transduction pathway.	Arginine	116-124	F-box protein 32	Mus musculus	129-138
11397844-4	2001	The present study examined whether this stimulation is dependent on binding of the Arg-Gly-Asp (RGD) domain of IGFBP-1 to an RGD binding site on the alpha 5 beta 1 integrin, followed by activation of focal adhesion kinase (FAK) and stimulation of the mitogen-activated protein kinase (MAPK) pathway.	Arginine	83-86	insulin like growth factor binding protein 1	Homo sapiens	111-118
18616983-7	2008	The inhibitory effect of leucine, isoleucine or arginine on atrogin-1 mRNA level was reversed by rapamycin, although wortmannin did not reverse the effect.	Arginine	48-56	F-box protein 32	Mus musculus	60-69
18616983-10	2008	Taken together, these findings indicated that leucine, isoleucine and arginine decreased atrogin-1 mRNA levels via mTOR and that different pathways were involved in the effect of those amino acids on MuRF1 mRNA levels.	Arginine	70-78	F-box protein 32	Mus musculus	89-98
18616983-10	2008	Taken together, these findings indicated that leucine, isoleucine and arginine decreased atrogin-1 mRNA levels via mTOR and that different pathways were involved in the effect of those amino acids on MuRF1 mRNA levels.	Arginine	70-78	mechanistic target of rapamycin kinase	Mus musculus	115-119
11382804-7	2001	Cotransport function of mutants with Cys substitutions at sites Arg-462 through Leu-465 showed low sensitivity to MTS reagents.	Arginine	64-67	translocase of inner mitochondrial membrane 8A L homeolog	Xenopus laevis	114-117
17689741-8	2008	Medication might influence l-arginine concentrations and the use of HMG CoA reductase inhibitors and beta-adrenoceptor antagonists at study inclusion was significantly less common in STEMI patients compared to NSTEMI and stable angina patients.	Arginine	27-37	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	68-85
11376115-1	2001	It has been shown previously that a naturally occurring mutation of the human LH/CG receptor (hLHR), which replaces L457 in helix III with arginine, results in a receptor that constitutively elevates basal cAMP but does not respond to human CG (hCG) with further cAMP production.	Arginine	139-147	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	94-98
18644376-5	2008	A positively charged arginine at position 512 in the n-Src loop of Eps8L1 SH3 plays a key role in PxxDY motif recognition by forming a salt bridge to D7 of the CD3epsilon peptide.	Arginine	21-29	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	160-170
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	85-88	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	127-130
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	97-100	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	127-130
11279004-5	2001	Conversely, expression of a kinase-active form of Abl or reconstitution of abl-/- arg-/- cells with wild-type Abl prevents Crk-CAS coupling and inhibits cell migration.	Arginine	82-85	v-crk avian sarcoma virus CT10 oncogene homolog	Mus musculus	123-126
18097518-6	2008	RESULTS: We found an SRD5A2 gene mutation in exon 5, where arginine is substituted with glutamine (R246Q), in two males with pseudohermaphroditism and ambiguous genitalia from unrelated families.	Arginine	59-67	steroid 5 alpha-reductase 2	Homo sapiens	21-27
18492952-3	2008	By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668), and together these exosite interactions increase the rate of substrate cleavage by at least approximately 300-fold.	Arginine	200-203	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	35-43
11300774-9	2001	We conclude that the residues corresponding to eNTPDase-3 glutamate 182 in ACR3 and serine 224 in ACR4 are essential for the enzymatic activity of eNTPDases in general, and that arginine 67, arginine 146, asparagine 191, and glutamine 226 are important for determining substrate specificity for human ecto-nucleoside triphosphate diphosphohydrolase 3.	Arginine	178-186	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	47-57
11300774-9	2001	We conclude that the residues corresponding to eNTPDase-3 glutamate 182 in ACR3 and serine 224 in ACR4 are essential for the enzymatic activity of eNTPDases in general, and that arginine 67, arginine 146, asparagine 191, and glutamine 226 are important for determining substrate specificity for human ecto-nucleoside triphosphate diphosphohydrolase 3.	Arginine	191-199	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	47-57
18492952-3	2008	By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668), and together these exosite interactions increase the rate of substrate cleavage by at least approximately 300-fold.	Arginine	200-203	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	129-137
18502798-2	2008	Hydrolysis by ADAMTS13 of a VWF analog (Asp(1596)-Arg(1668) peptide, fluorescence energy transfer substrate [FRETS]-VWF73) was investigated by a fluorescence quenching method (FRETS method) from 15 degrees C to 45 degrees C and pH values from 4.5 to 10.5.	Arginine	50-53	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	14-22
11355300-4	2001	We also observed a known polymorphism at hBUBR1 codon 349 (CAA/CGA, Gln/Arg), with an allelic frequency of 0.75 for Gln and 0.25 for Arg, which is similar to that among healthy Caucasian individuals (0.73 vs 0.27).	Arginine	72-75	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	41-47
11355300-4	2001	We also observed a known polymorphism at hBUBR1 codon 349 (CAA/CGA, Gln/Arg), with an allelic frequency of 0.75 for Gln and 0.25 for Arg, which is similar to that among healthy Caucasian individuals (0.73 vs 0.27).	Arginine	133-136	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	41-47
18502798-8	2008	The interaction of the Met(1606)-Arg(1668) region of VWF with ADAMTS13 involves basic residues of the protease and is thus progressively inhibited at pH values &gt;8.50.	Arginine	33-36	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	62-70
18660751-6	2008	The downregulation of PCSK9 affected the levels of the loss-of-acetylation mutants (BACE1(Ala) and BACE1(Arg)) but not those of the gain-of-acetylation mutant (BACE1(Gln)).	Arginine	105-108	proprotein convertase subtilisin/kexin type 9	Mus musculus	22-27
11293168-2	2001	Polymerase chain reaction-single strand conformation polymorphism and DNA sequencing revealed a single nucleotide substitution on exon 7 of the human androgen receptor (hAR) gene, resulting in a change of CGA (arginine) to CAA (glutamine) in codon 831.	Arginine	210-218	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	169-172
18698489-4	2008	In the present study, we determined that EWS was physically associated with PRMT8, the novel eighth member of the PRMT family, through the COOH-terminal region of EWS including RGG3 with the NH2-terminal region of PRMT8 encompassing the S-adenosyl-L-methionine binding domain, and that arginine residues in EWS were asymmetrically dimethylated by PRMT8 using amino acid analysis with thin-layer chromatography.	Arginine	286-294	protein arginine methyltransferase 8	Homo sapiens	76-81
11386462-0	2001	A family of multiple endocrine neoplasia type 2A with the RET proto-oncogene mutation in codon 618 (Cys--&gt;Arg).	Arginine	109-112	ret proto-oncogene	Homo sapiens	58-61
11386462-3	2001	We report here three generations of one MEN-2 family with rare missense mutation at codon 618 (Cys--&gt;Arg) of the RET proto-oncogene.	Arginine	104-107	ret proto-oncogene	Homo sapiens	116-119
18716165-1	2008	In intestinal cells, arginine (Arg) is 1 of the 2 most potent amino acid activators of p70(s6k), a key regulator of 5"- terminal oligopyrimidine mRNA translation, a necessary condition for increased cell migration.	Arginine	21-29	ribosomal protein S6 kinase B1	Rattus norvegicus	87-94
11230128-4	2001	The binding motif of DnaJ consists of a hydrophobic core of approximately eight residues enriched for aromatic and large aliphatic hydrophobic residues and arginine.	Arginine	156-164	DnaJ	Escherichia coli	21-25
18716165-1	2008	In intestinal cells, arginine (Arg) is 1 of the 2 most potent amino acid activators of p70(s6k), a key regulator of 5"- terminal oligopyrimidine mRNA translation, a necessary condition for increased cell migration.	Arginine	31-34	ribosomal protein S6 kinase B1	Rattus norvegicus	87-94
18716165-3	2008	When treated with Arg, cdx2-IEC increased in phosphorylation on Thr-389 of p70(s6k) (pp70(s6k)) compared with control (P &lt; 0.01).	Arginine	18-21	ribosomal protein S6 kinase B1	Rattus norvegicus	75-82
11207289-0	2001	Gorillas with spondyloarthropathies express an MHC class I molecule with only limited sequence similarity to HLA-B27 that binds peptides with arginine at P2.	Arginine	142-150	major histocompatibility complex, class I, B	Homo sapiens	109-116
18716165-3	2008	When treated with Arg, cdx2-IEC increased in phosphorylation on Thr-389 of p70(s6k) (pp70(s6k)) compared with control (P &lt; 0.01).	Arginine	18-21	ribosomal protein S6 kinase B1	Rattus norvegicus	79-82
11207289-8	2001	Indeed, the peptide binding motif and sequence of individual ligands eluted from Gogo-B*0101 demonstrate that, like HLA-B27, this gorilla MHC class I molecule binds peptides with arginine at the second amino acid position of peptides bound by the MHC class I molecule.	Arginine	179-187	major histocompatibility complex, class I, B	Homo sapiens	116-123
18716165-4	2008	Phospho-Thr-421/Ser-424-p70(s6k) was located in the nucleus shortly after Arg treatment.	Arginine	74-77	ribosomal protein S6 kinase B1	Rattus norvegicus	28-31
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	177-180	CD2 molecule	Homo sapiens	28-31
18716165-5	2008	Arg enhanced pp70(s6k), cell migration (55% wound coverage), and NO production.	Arginine	0-3	ribosomal protein S6 kinase B1	Rattus norvegicus	18-21
18716165-9	2008	These and our previous studies lead to a model in which Arg must stimulate both pp70(s6k) (in the nucleus) and NO release to enhance intestinal epithelial cell migration, which may be relevant to diseases that involve intestinal villous injury.	Arginine	56-59	ribosomal protein S6 kinase B1	Rattus norvegicus	85-88
11266121-7	2001	By analyzing the data, we were able to draw the following conclusions: (1) The arginine residues are found in the CDR3 regions of both VH and VL of the co-dominant antibodies; whereas, the same residues are found only in the CDR3s of VH, but not in VL, of the heavy chain dominant antibodies.	Arginine	79-87	cerebellar degeneration-related 3	Mus musculus	114-118
11266121-7	2001	By analyzing the data, we were able to draw the following conclusions: (1) The arginine residues are found in the CDR3 regions of both VH and VL of the co-dominant antibodies; whereas, the same residues are found only in the CDR3s of VH, but not in VL, of the heavy chain dominant antibodies.	Arginine	79-87	cerebellar degeneration-related 3	Mus musculus	225-229
11266121-9	2001	From the results of this study it is suggested that the presence of arginine residue in CDR3 is a critical factor in determining chain-dominance, as well as DNA binding of anti-DNA antibodies in general.	Arginine	68-76	cerebellar degeneration-related 3	Mus musculus	88-92
11160269-2	2001	We show here that IL-4 and IL-13 regulate NO production through depletion of arginine, the substrate of inducible NO synthase (iNOS).	Arginine	77-85	interleukin 4	Mus musculus	18-22
11073948-7	2001	Replacement of lysine by arginine at all of these sites dramatically decreased the trans-activating capacity of c-Myb.	Arginine	25-33	MYB proto-oncogene, transcription factor	Homo sapiens	112-117
11360998-2	2001	The model suggests that Arg-469 may play an important role in maintaining the substrate-bound conformation of hsc70.	Arginine	24-27	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	110-115
11024031-0	2001	The function of Arg-94 in the oxidation and decarboxylation of glutaryl-CoA by human glutaryl-CoA dehydrogenase.	Arginine	16-19	glutaryl-CoA dehydrogenase	Homo sapiens	85-111
11024031-3	2001	Glutaryl-CoA dehydrogenase is the only member of the acyl-CoA dehydrogenase family with a cationic residue, Arg-94, situated in the binding site of the acyl moiety of the substrate.	Arginine	108-111	glutaryl-CoA dehydrogenase	Homo sapiens	0-26
11436200-4	2001	The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg).	Arginine	132-135	H3 histone pseudogene 16	Homo sapiens	26-29
11280065-6	2001	Interestingly, Gly-437 in dhps along with Arg-59/Asn-108 in dhfr were associated with RI, RII and RIII resistance whereas Glu-540 was highly associated with only RII and RIII Fansidar resistance.	Arginine	42-45	dihydrofolate reductase	Homo sapiens	60-64
11338505-10	2001	The mutation results in substitution of cysteine amino acid residue in the cysteine-rich extracellular domain of protein kinase encoded by the gene RET for arginine.	Arginine	156-164	ret proto-oncogene	Homo sapiens	148-151
11281260-6	2000	In particular, all the cysteine residues involved in disulfide bonding and an arginine residue, which is considered to be part of the mannose 6-phosphate binding site in cassette 3 of mammalian MPR 300, are conserved.	Arginine	78-86	insulin like growth factor 2 receptor	Homo sapiens	194-201
10954711-3	2000	Despite the lack of obvious homology to any known catalytic domains of GTPase-activating proteins (GAPs), the BCH domain of BNIP-2 bound Cdc42 and stimulated the GTPase activity via a novel arginine-patch motif similar to that employed by one contributing partner in a Cdc42 homodimer.	Arginine	190-198	BCL2 interacting protein 2	Homo sapiens	124-130
11139366-1	2000	l-Arginine is metabolized either to polyamines through arginase and ornithine decarboxylase (ODC) activities or to citrulline and nitric oxide (NO, nitrogen monoxide) through the NO synthase (NOS) pathway.	Arginine	0-10	ornithine decarboxylase 1	Rattus norvegicus	68-91
11139366-1	2000	l-Arginine is metabolized either to polyamines through arginase and ornithine decarboxylase (ODC) activities or to citrulline and nitric oxide (NO, nitrogen monoxide) through the NO synthase (NOS) pathway.	Arginine	0-10	ornithine decarboxylase 1	Rattus norvegicus	93-96
11191882-3	2000	We have found the following frequencies of mutated alleles: CYP1A1-m2, 0.097; CYP2E1-C, 0.077; CYP2E1-c2, 0.023; EPHX(exon 3)-His, 0.381; EPHX(exon 4)-Arg, 0.198; GSTM1-null, 0.51; GSTP1-Val, 0.3; GSTT1-null, 0.164.	Arginine	151-154	epoxide hydrolase 1	Homo sapiens	113-117
10956652-2	2000	Two arginine residues in positions B13 and B17 that project like forefinger and middle finger from the helix provide the electrostatic element opposed by the hydrophobic (thumb) element isoleucine (B20), offset from the arginines by about 40 degrees.	Arginine	4-12	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	35-38
10956652-2	2000	Two arginine residues in positions B13 and B17 that project like forefinger and middle finger from the helix provide the electrostatic element opposed by the hydrophobic (thumb) element isoleucine (B20), offset from the arginines by about 40 degrees.	Arginine	220-229	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	35-38
11095426-0	2000	Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.	Arginine	71-74	adrenoceptor beta 3	Homo sapiens	93-119
11095426-2	2000	The Arg 64 beta-3-adrenergic receptor variant allele is associated with an earlier age of onset of type 2 DM.	Arginine	4-7	adrenoceptor beta 3	Homo sapiens	11-37
11095426-6	2000	This first report of decreased acute insulin release and lower glucose effectiveness in the Arg 64 genotype may help explain the earlier onset of type 2 DM observed in several populations of individuals with the Arg64 beta-3-adrenergic receptor variant allele.	Arginine	92-95	adrenoceptor beta 3	Homo sapiens	218-244
11062536-5	2000	Nude mice inoculated with human prostate tumor cells secreting prostate-specific antigen showed considerable reductions in tumor burden with minimal total body weight loss when treated with L-377, 202.	Arginine	190-192	kallikrein related peptidase 3	Homo sapiens	63-88
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Arginine	104-107	thrombomodulin	Homo sapiens	21-35
10931847-10	2000	Furthermore, overexpression of the truncated U2AF65, which contains the arginine and serine dipeptide-rich domain and linker domain, but lacks the RNA binding domain, selectively inhibits the IDDE-mediated N30 inclusion in mRNA from the wild-type minigene in a dominant negative fashion.	Arginine	72-80	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	45-51
11044768-6	2000	The tissue-associated myeloperoxidase activity was decreased in the liver by L-NNA and L-ARG.	Arginine	87-92	myeloperoxidase	Rattus norvegicus	22-37
11069088-5	2000	The putative centerin protein shares the highest sequence identity with thyroxine-binding globulin and possesses arginine/serine at its P1/P1" active site, suggesting that it interacts with a trypsin-like protease(s).	Arginine	113-121	serpin family A member 9	Homo sapiens	13-21
11089639-11	2000	The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does.	Arginine	240-243	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	98-102
11089639-11	2000	The model predicted a pattern of interactions between amino acids and DNA bases which reflect for ARNT what is experimentally observed among different X-ray structures of other bHLH transcription factors possessing the H (His), E (Glu), R (Arg) triad, as ARNT does.	Arginine	240-243	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	255-259
11003790-11	2000	These results suggest the presence of molecular modification of the product of expanded (GCG) repeat in PABP2, since the synthetic antigen peptide may not recognize a highly dimethylated cluster of arginine residues of the native PABP2, but may recognize the mutated form.	Arginine	198-206	poly(A) binding protein nuclear 1	Homo sapiens	104-109
10970801-10	2000	All these results suggest that although Pro-297 is indirectly involved in catalysis, it might not have any role in imparting substrate specificity, unlike the similarly positioned Arg-292 in aspartate aminotransferase.	Arginine	180-183	aspartate aminotransferase, mitochondrial	Ovis aries	191-217
18509066-10	2008	The Arg residue in the ERY motif of UT is an important structural element in signaling crossroads that determine whether Galpha(q/11)-dependent and -independent events can occur.	Arginine	4-7	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	121-132
18554750-6	2008	Molecular modeling suggested that the conserved arginine is critical for binding to an equally conserved acidic pocket in NPR-B.	Arginine	48-56	natriuretic peptide receptor 2	Mus musculus	122-127
10874034-12	2000	The Arg residues in these two mutants are restricted to a highly conserved, 13-residue segment of Gsy2p that we propose to be important for glucose-6-P binding and/or the ability of the enzyme to undergo transitions between activity states.	Arginine	4-7	glycogen (starch) synthase GSY2	Saccharomyces cerevisiae S288C	98-103
18600814-4	2008	The reactivity achieved with the HJ1 polypeptide, rationally designed to catalyze the hydrolysis of phosphodiesters, is based on two histidine residues flanked by four arginines and two adjacent tyrosine residues, all located on the surface of a helix-loop-helix motif.	Arginine	168-177	jagged canonical Notch ligand 1	Homo sapiens	33-36
10950805-3	2000	P. falciparum infections were analyzed by polymerase chain reaction for DHFR mutations, which were dramatically more frequent among prophylaxis-breakthrough infections than at baseline: the prevalence of Asn-108 rose from 13% to 100%, Ile-51 from 4% to 50%, and Arg-59 from 11% to 90%.	Arginine	262-265	dihydrofolate reductase	Homo sapiens	72-76
18505723-6	2008	Mass spectrometric analysis of the AT(1)R-associated short form suggested a scissile site located within the Arg(363)-Arg(393) region in the bovine beta-arrestin 1.	Arginine	109-112	angiotensin II, type I receptor-associated protein	Mus musculus	35-41
10966646-4	2000	The primary specificity for Asp occurs through a side-on interaction with Arg 226, a buried Arg side chain of granzyme B.	Arginine	74-77	granzyme B	Homo sapiens	110-120
18505723-6	2008	Mass spectrometric analysis of the AT(1)R-associated short form suggested a scissile site located within the Arg(363)-Arg(393) region in the bovine beta-arrestin 1.	Arginine	109-112	arrestin beta 1	Bos taurus	148-163
10966646-4	2000	The primary specificity for Asp occurs through a side-on interaction with Arg 226, a buried Arg side chain of granzyme B.	Arginine	92-95	granzyme B	Homo sapiens	110-120
18505723-6	2008	Mass spectrometric analysis of the AT(1)R-associated short form suggested a scissile site located within the Arg(363)-Arg(393) region in the bovine beta-arrestin 1.	Arginine	118-121	angiotensin II, type I receptor-associated protein	Mus musculus	35-41
18505723-6	2008	Mass spectrometric analysis of the AT(1)R-associated short form suggested a scissile site located within the Arg(363)-Arg(393) region in the bovine beta-arrestin 1.	Arginine	118-121	arrestin beta 1	Bos taurus	148-163
18566001-5	2008	A substitution of three arginines in the intracellular vestibule of 5-HT(3A) with their counterpart residues from the 5-HT(3B) subunit (RRR-QDA) was previously shown to dramatically increase single channel conductance.	Arginine	24-33	5-hydroxytryptamine receptor 3B	Homo sapiens	118-125
11012986-7	2000	The beta-catenin mutation was identified in only one case of conventional renal carcinoma and was a single-base missense mutation on codon 61, leading to substitution of glutamine by arginine.	Arginine	183-191	catenin beta 1	Homo sapiens	4-16
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	Arginine	124-127	lysophosphatidic acid receptor 5	Homo sapiens	71-76
10915101-3	2000	Of 12 different unmixed allelic combinations, the triple dhfr mutation Asn-108/Arg-59/Ile-51 was observed in all patients responding with early treatment failure.	Arginine	79-82	dihydrofolate reductase	Homo sapiens	57-61
10954027-2	2000	The prevalence of the Arg allele of the Arg16Gly polymorphism in the beta2-ADR gene was higher (49%) in males with a body mass index (BMI) of 35 kg/m2 or higher versus those with a BMI less than 35 kg/m2 (33%; P = .010).	Arginine	22-25	adrenoceptor beta 3	Homo sapiens	75-78
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	Arginine	124-127	lysophosphatidic acid receptor 5	Homo sapiens	136-141
10965952-4	2000	The arginine-requiring strain arg7-8 was transformed with DNA carrying the wild-type ARG7 gene.	Arginine	4-12	uncharacterized protein	Chlamydomonas reinhardtii	30-34
18499677-4	2008	Computer-simulated modeling combined with site-directed mutagenesis of GPR92 indicated that Thr(97), Gly(98), Phe(101), and Arg(267) of GPR92 are responsible for the interaction of GPR92 with FPP and NAG.	Arginine	124-127	lysophosphatidic acid receptor 5	Homo sapiens	136-141
10965952-4	2000	The arginine-requiring strain arg7-8 was transformed with DNA carrying the wild-type ARG7 gene.	Arginine	4-12	uncharacterized protein	Chlamydomonas reinhardtii	85-89
18586034-2	2008	Our results show that after 4 weeks of streptozotocin-induced diabetes, treatment with L-arginine restored NO levels and prevented tissue accumulation of sorbitol in mice, which was accompanied by an increase in glutathiolation of aldose reductase.	Arginine	87-97	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	231-247
10937801-7	2000	Although the Arg11O residue is located distal to the tissue factor (TF) in the soluble TF-FVIIa crystal structure, we infer that the replacement of the positively charged and larger Arg residue with a neutral Cys residue may be likely to impair proper folding, resulting in destabilization of the protein structure.	Arginine	13-16	coagulation factor III, tissue factor	Homo sapiens	68-70
18604831-6	2008	The best analogue was more efficient than either (Arg)(4) or (Arg)(8) linked to geminin.	Arginine	50-53	geminin DNA replication inhibitor	Homo sapiens	80-87
10749851-9	2000	Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 and ILF3 and is the site of ILF3 methylation by PRMT1.	Arginine	86-94	interleukin enhancer binding factor 3	Homo sapiens	63-67
10749851-9	2000	Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 and ILF3 and is the site of ILF3 methylation by PRMT1.	Arginine	86-94	interleukin enhancer binding factor 3	Homo sapiens	177-181
10749851-9	2000	Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 and ILF3 and is the site of ILF3 methylation by PRMT1.	Arginine	86-94	interleukin enhancer binding factor 3	Homo sapiens	177-181
18604831-6	2008	The best analogue was more efficient than either (Arg)(4) or (Arg)(8) linked to geminin.	Arginine	62-65	geminin DNA replication inhibitor	Homo sapiens	80-87
10866325-8	2000	N-Hydroxy-L-arginine (NOHA), a stable intermediate product formed during conversion of L-arginine to NO, inhibited proliferation of the high arginase-expressing MDA-MB-468 cells and induced apoptosis after 48 h. NOHA arrested these cells in the S phase, increased the expression of p21, and reduced spermine content.	Arginine	10-20	H3 histone pseudogene 16	Homo sapiens	282-285
18499678-4	2008	Chromatin immunoprecipitation assays showed a dynamic change of p53 and PAD4 occupancy and histone Arg modifications at the OKL38 promoter during DNA damage, suggesting a direct role of PAD4 and p53 in the expression of OKL38.	Arginine	99-102	oxidative stress induced growth inhibitor 1	Homo sapiens	124-129
18318660-9	2008	Alanine scanning mutagenesis identified Arg(6) of mupain-1 as the P1 residue and indicated an extended binding interaction including the P5, P3, P2, P1 and P1" residues of mupain-1 and the specificity pocket, the catalytic triad and amino acids 41, 99 and 192 located in and around the active site of murine uPA.	Arginine	40-43	plasminogen activator, urokinase	Mus musculus	308-311
18507410-3	2008	The approach immobilizes the fibronectin-derived cell adhesion ligand Arg-Gly-Asp-Ser-Pro (RGDSP) using carbodiimide activation chemistry and immobilizes DNA strands on the same surface via cDNA-DNA interactions.	Arginine	70-73	fibronectin 1	Mus musculus	29-40
10843666-3	2000	In marked contrast, LPS stimulates Th2, but not Th1, macrophages to increase arginine metabolism to ornithine.	Arginine	77-85	heart and neural crest derivatives expressed 2	Mus musculus	35-38
18400300-4	2008	Previous results using peptide inhibitors led to the hypothesis that a highly positively charged domain consisting of three arginine residues, such as that present in the N-terminal collagen-like region of the human C1q A chain, may be critical for the activation event.	Arginine	124-132	complement C1q A chain	Homo sapiens	216-221
10928623-1	2000	The molecular defect underlying activated protein C resistance (APC-R) is caused by a G to A point mutation in the codon for arginine 506 in the factor V gene (factor V Leiden) which is a major risk factor for venous thrombosis, especially in Caucasian populations.	Arginine	125-133	coagulation factor V	Homo sapiens	160-175
18400300-5	2008	However, mouse C1q A chain lacks two of the three arginines in the corresponding C1q A chain collagen-like region.	Arginine	50-59	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	15-18
10837517-7	2000	The most abundant variants in coding sequence of p21 gene were a C to A transversion at codon 31 which resulted in Ser to Arg and had been identified being polymorphism.	Arginine	122-125	H3 histone pseudogene 16	Homo sapiens	49-52
18400300-11	2008	Molecular modeling based on the published crystal structure of human C1q B chain globular head and a beta-sheet model for fibrillar amyloid suggests an alternative arginine ladder in the globular head domain may provide the functional C1 activating interaction domains.	Arginine	164-172	complement C1q A chain	Homo sapiens	69-72
10799524-2	2000	BNIP-2 contains many arginine residues at the carboxyl terminus, which includes the region of homology to the noncatalytic domain of Cdc42GAP, termed BNIP-2 and Cdc42GAP homology (BCH) domain.	Arginine	21-29	BCL2 interacting protein 2	Homo sapiens	0-6
18362146-9	2008	Blocking of integrins with an Arg-Gly-Asp-containing peptide counteracted the matrix contacts necessary to initiate the uPAR-dependent cytoskeletal rearrangements, whereas inactivation of the Rac signaling pathway in all cases suppressed the occurrence of the same events.	Arginine	30-33	plasminogen activator, urokinase receptor	Homo sapiens	120-124
10799301-3	2000	Inhibition of LPS/IFN-gamma-induced NO synthesis with the L-arginine analogue N(G)-monomethyl-L-arginine (L-NMMA) was accompanied by a significant up-regulation of iNOS mRNA that was reversed in the presence of the NO donor sodium nitroprusside (SNP).	Arginine	58-68	interferon regulatory factor 6	Homo sapiens	14-27
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	99-102	laminin, alpha 1	Mus musculus	221-235
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Arginine	65-75	sucrase-isomaltase	Homo sapiens	267-284
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	laminin, alpha 1	Mus musculus	221-235
10810293-7	2000	Finally, in the presence of the NO synthase inhibitor N(G)-nitro-l-arginine methyl ester, insulin release from isolated islets stimulated by glucose or l-arginine was markedly potentiated in parallel with an accompanying increase in the activities of acid glucan-1,4-alpha-glucosidase and acid alpha-glucosidase.	Arginine	65-75	sucrase-isomaltase	Homo sapiens	294-311
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	laminin, alpha 1	Mus musculus	221-235
10810293-9	2000	We propose that an important inhibitory effect of NO on the insulin secretory processes stimulated by glucose and l-arginine is exerted via inactivation of islet acid glucan-1,4-alpha-glucosidase, a putative key enzyme in nutrient-stimulated insulin release.	Arginine	114-124	sucrase-isomaltase	Homo sapiens	178-195
18215127-5	2008	Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the mouse laminin alpha1 G4 domain.	Arginine	107-110	laminin, alpha 1	Mus musculus	221-235
18425413-0	2008	Triple arginines in the cytoplasmic tail of endomannosidase are not essential for type II membrane topology and Golgi localization.	Arginine	7-16	mannosidase, endo-alpha	Rattus norvegicus	44-59
10839134-10	2000	The results indicated that CE-LIF is useful as a selective, rapid, cheap and sensitive tool for the determination of methylated arginine products.	Arginine	128-136	LIF interleukin 6 family cytokine	Homo sapiens	30-33
18203755-1	2008	We investigated a family with a brachydactyly type A2 and identified a heterozygous arginine to glutamine (R380Q) substitution in the growth/differentiation factor 5 (GDF5) in all affected individuals.	Arginine	84-92	growth differentiation factor 5	Gallus gallus	134-165
10803844-6	2000	Pool sequencing of radiolabeled peptides bound by this molecule demonstrated that, like HLA-B27 and HLA-B39, it could bind peptides with arginine at the second position.	Arginine	137-145	major histocompatibility complex, class I, B	Homo sapiens	88-95
10805501-7	2000	RESULTS: In Trp64Arg polymorphism of the beta3-AR gene, the number of obese subjects with Trp/Arg or Arg/Arg genotypes was significantly higher than that of the non-obese subjects (chi2=5.79, P=0.02).	Arginine	17-20	adrenoceptor beta 3	Homo sapiens	41-49
10805501-7	2000	RESULTS: In Trp64Arg polymorphism of the beta3-AR gene, the number of obese subjects with Trp/Arg or Arg/Arg genotypes was significantly higher than that of the non-obese subjects (chi2=5.79, P=0.02).	Arginine	94-97	adrenoceptor beta 3	Homo sapiens	41-49
10805501-7	2000	RESULTS: In Trp64Arg polymorphism of the beta3-AR gene, the number of obese subjects with Trp/Arg or Arg/Arg genotypes was significantly higher than that of the non-obese subjects (chi2=5.79, P=0.02).	Arginine	94-97	adrenoceptor beta 3	Homo sapiens	41-49
10706884-0	2000	A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.	Arginine	29-32	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	54-58
10706884-0	2000	A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.	Arginine	29-32	H3 histone pseudogene 6	Homo sapiens	114-117
10706884-3	2000	We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)(q22;q11.2) and a t(1;12)(q25;p13), which has the remarkable feature to differentiate to mature eosinophils in culture with all-trans retinoic acid and cytokines.	Arginine	41-44	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	66-70
18203755-1	2008	We investigated a family with a brachydactyly type A2 and identified a heterozygous arginine to glutamine (R380Q) substitution in the growth/differentiation factor 5 (GDF5) in all affected individuals.	Arginine	84-92	growth differentiation factor 5	Gallus gallus	167-171
18425142-5	2008	SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP.	Arginine	55-63	SRSF protein kinase 2	Homo sapiens	0-5
10706884-3	2000	We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)(q22;q11.2) and a t(1;12)(q25;p13), which has the remarkable feature to differentiate to mature eosinophils in culture with all-trans retinoic acid and cytokines.	Arginine	41-44	H3 histone pseudogene 6	Homo sapiens	217-220
18425142-5	2008	SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP.	Arginine	55-63	DEAD-box helicase 23	Homo sapiens	100-105
10694430-10	2000	A lysine to arginine mutation abolished MITF (K201R) degradation by hUBC9 in vivo.	Arginine	12-20	melanocyte inducing transcription factor	Homo sapiens	40-44
18425142-5	2008	SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP.	Arginine	55-63	DEAD-box helicase 23	Homo sapiens	115-120
18425142-5	2008	SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP.	Arginine	55-63	DEAD-box helicase 23	Homo sapiens	115-120
18280260-6	2008	In obstructed neonatal rats, in vivo administration of l-Arginine induced heat shock protein 70 (Hsp70) expression, which was associated with cytoprotection from apoptosis and transiently decreased nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activity.	Arginine	55-65	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	74-95
10728423-1	2000	OBJECTIVES: We report the functional expression of four KCNQ1 mutations affecting arginine residues and resulting in Romano-Ward (RW) and the Jervell and Lange-Nielsen (JLN) congenital long QT syndromes.	Arginine	82-90	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	56-61
18280260-6	2008	In obstructed neonatal rats, in vivo administration of l-Arginine induced heat shock protein 70 (Hsp70) expression, which was associated with cytoprotection from apoptosis and transiently decreased nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activity.	Arginine	55-65	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	97-102
10720581-6	2000	However, only 22% of 58 CYP11B2 alleles studied in 29 patients with low-renin hypertension were Arg(173) alleles, whereas the frequency of this allele was 41% in patients with normal- or high-renin hypertension (P=0.033).	Arginine	96-99	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	24-31
10720581-11	2000	The decreased frequencies of the Arg(173) and -344C variants in the CYP11B2 appear to be genetically linked to low-renin hypertension in the Japanese population studied.	Arginine	33-36	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	68-75
18280260-8	2008	The interaction between B-cell lymphoma 2 anti-apoptotic members (BcL(2)) and Hsp70 in the presence of L-Arginine and L-NAME, was determined by coimmunoprecipitation.	Arginine	103-113	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	78-83
18280260-9	2008	Binding of BcL(2) and Hsp70 increased after L-Arginine administration.	Arginine	44-54	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	22-27
18292211-1	2008	Carboxypeptidase M (CPM) is a membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins.	Arginine	117-125	carboxypeptidase M	Homo sapiens	0-18
10688655-0	2000	ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginine.	Arginine	72-80	transcription factor MCM1	Saccharomyces cerevisiae S288C	32-36
10688655-0	2000	ArgRII, a component of the ArgR-Mcm1 complex involved in the control of arginine metabolism in Saccharomyces cerevisiae, is the sensor of arginine.	Arginine	138-146	transcription factor MCM1	Saccharomyces cerevisiae S288C	32-36
10688655-3	2000	Using purified glutathione S-transferase fusion proteins, we demonstrate that ArgRI and ArgRII1-180 or Mcm1 and ArgRII1-180 are able to reconstitute an arginine-dependent binding activity in mobility shift analysis.	Arginine	152-160	transcription factor MCM1	Saccharomyces cerevisiae S288C	103-107
18307268-5	2008	Genetic testing revealed a heterozygous G to C mutation at the first base of codon 389 of the MAPT gene, changing glycine to arginine (G389R), in the patient and his unaffected elderly father.	Arginine	125-133	microtubule associated protein tau	Homo sapiens	94-98
18281275-6	2008	Other amino acids participating in AC cleavage included Arg-159 and Asp-162.	Arginine	56-59	N-acylsphingosine amidohydrolase 1	Homo sapiens	35-37
18309292-0	2008	The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.	Arginine	71-79	LDL receptor related protein associated protein 1	Homo sapiens	4-7
18281307-3	2008	METHODS: By site-directed mutagenesis and by use of the bla(CTX-M-1) gene as template, Arg-276 was replaced with six different amino acids (Trp, His, Cys, Asn, Gly and Ser).	Arginine	87-90	CTX-M-1	Escherichia coli	60-67
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	48-51	cilia and flagella associated protein 20	Homo sapiens	176-200
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	48-51	cilia and flagella associated protein 20	Homo sapiens	202-207
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	55-58	cilia and flagella associated protein 20	Homo sapiens	176-200
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	55-58	cilia and flagella associated protein 20	Homo sapiens	202-207
10707958-6	2000	It is concluded that the functioning of positively charged Arg-18/Arg-22 as part of an hVDR docking site for TFIIB is influenced by the composition of the adjacent polymorphic N terminus.	Arginine	59-62	cilia and flagella associated protein 20	Homo sapiens	109-114
10707958-6	2000	It is concluded that the functioning of positively charged Arg-18/Arg-22 as part of an hVDR docking site for TFIIB is influenced by the composition of the adjacent polymorphic N terminus.	Arginine	66-69	cilia and flagella associated protein 20	Homo sapiens	109-114
10809003-4	2000	Of the five detected SR1 transcripts only one encodes the full-length protein, while the other four are different variants of the essential arginine-serine-rich domain.	Arginine	140-148	signal responsive 1	Arabidopsis thaliana	21-24
10660576-5	2000	Computer analysis of the R2R3 three-dimensional structure, as well as extensive mutational analysis within this region, reveals that the Arg(161) residue, present in c-Myb and A-Myb, but not B-Myb, is crucial for this interaction.	Arginine	137-140	MYB proto-oncogene, transcription factor	Homo sapiens	166-171
10660576-5	2000	Computer analysis of the R2R3 three-dimensional structure, as well as extensive mutational analysis within this region, reveals that the Arg(161) residue, present in c-Myb and A-Myb, but not B-Myb, is crucial for this interaction.	Arginine	137-140	MYB proto-oncogene like 1	Homo sapiens	176-181
10653645-0	2000	Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".	Arginine	32-41	thymidylate synthetase	Homo sapiens	66-86
10653645-1	2000	In thymidylate synthase, four conserved arginines provide two hydrogen bonds each to the oxygens of the phosphate group of the substrate, 2"-deoxyuridine-5"-monophosphate.	Arginine	40-49	thymidylate synthetase	Homo sapiens	3-23
10642527-6	2000	The predicted LKB1 protein sequence terminates with a conserved prenylation motif (Cys(433)-Lys-Gln-Gln(436)) directly downstream from a consensus cAMP-dependent protein kinase (PKA) phosphorylation site (Arg(428)-Arg-Leu-Ser(431)).	Arginine	205-208	serine/threonine kinase 11	Homo sapiens	14-18
10642527-6	2000	The predicted LKB1 protein sequence terminates with a conserved prenylation motif (Cys(433)-Lys-Gln-Gln(436)) directly downstream from a consensus cAMP-dependent protein kinase (PKA) phosphorylation site (Arg(428)-Arg-Leu-Ser(431)).	Arginine	214-217	serine/threonine kinase 11	Homo sapiens	14-18
10688364-3	2000	For example, at the R/G editing site of gluR-B, -C, and -D RNAs, ADARs change an arginine codon (AGA) to a glycine codon (IGA) so that two protein isoforms can be synthesized from a single encoded mRNA; the highly related gluR-A sequence is not edited at this site.	Arginine	81-89	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	222-228
18266824-4	2008	In both cases, this strategy allowed the production of genuine aprotinin with its N-terminal arginine residue.	Arginine	93-101	pancreatic trypsin inhibitor	Bos taurus	63-72
10709858-3	2000	In this context, it is notable that cell types that do not have a complete urea cycle often possess the urea cycle enzymes argininosuccinate synthase and argininosuccinate lyase; together, these enzymes confer the ability to regenerate arginine from the NOS product, L-citrulline.	Arginine	236-244	argininosuccinate synthase 1	Homo sapiens	123-149
18441513-4	2008	This study investigated the effect of the Arg allele of beta(3)-AR on caffeine-induced increases in EE.	Arginine	42-45	adrenoceptor beta 3	Homo sapiens	56-66
10709858-4	2000	Herein, the authors summarize evidence to support the view that argininosuccinate synthase and argininosuccinate lyase function in an arginine-citrulline cycle, providing a ready source of arginine for high-output NO synthesis.	Arginine	134-142	argininosuccinate synthase 1	Homo sapiens	64-90
10709858-4	2000	Herein, the authors summarize evidence to support the view that argininosuccinate synthase and argininosuccinate lyase function in an arginine-citrulline cycle, providing a ready source of arginine for high-output NO synthesis.	Arginine	189-197	argininosuccinate synthase 1	Homo sapiens	64-90
10673366-8	2000	Adhesion via alpha5beta1 is mediated by the Arg-Gly-Asp (RGD) motif of OPN, as mutating this sequence to Arg-Ala-Asp (RAD) blocked binding of both cell types.	Arginine	44-47	secreted phosphoprotein 1	Homo sapiens	71-74
17973264-3	2008	In this work, we describe an albumin-binding prodrug, EMC-Arg-Ser-Ser-Tyr-Tyr--Ser-Arg-DOXO [EMC: epsilon-Maleimidocaproic acid; DOXO = doxorubicin; X = amino acid] that is cleaved by PSA.	Arginine	58-61	kallikrein related peptidase 3	Homo sapiens	184-187
10620363-9	2000	A continuous, fluorescent ECE-1 assay has been developed using a novel substrate, 2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-(p-nitro-Phe(8))-Arg.	Arginine	140-145	endothelin converting enzyme 1	Homo sapiens	26-31
18250299-6	2008	Point mutations in PCSK9 that altered key residues contributing to EGF-A binding (Arg-194 and Phe-379) greatly diminished binding to the LDLR"s extracellular domain.	Arginine	82-85	proprotein convertase subtilisin/kexin type 9	Homo sapiens	19-24
11193182-4	2000	The mutation creates an arginine codon; translational read-through generates a novel protein, termed BRI-L, that is extended by 11 amino acids at the carboxyl-terminus.	Arginine	24-32	interferon induced transmembrane protein 5	Homo sapiens	101-106
18250299-6	2008	Point mutations in PCSK9 that altered key residues contributing to EGF-A binding (Arg-194 and Phe-379) greatly diminished binding to the LDLR"s extracellular domain.	Arginine	82-85	low density lipoprotein receptor	Homo sapiens	137-141
18271919-2	2008	POEM has several characteristics of a matrix protein including an arg-gly-asp binding domain site that is recognized by integrins.	Arginine	66-69	nephronectin	Homo sapiens	0-4
10846151-5	2000	Arginine restriction produced by arginase or arginine decarboxylase addition to culture medium gave similar results.	Arginine	0-8	antizyme inhibitor 2	Homo sapiens	45-67
10608868-4	1999	Only four positions in loop 3 of uPAR domain I exhibited significant changes in the contribution to the free energy of uPA binding (DeltaDeltaG &gt;/= 1.3 kcal mol(-1)) upon single-site substitutions to alanine (i.e. Arg(53), Leu(55), Tyr(57), and Leu(66)).	Arginine	217-220	plasminogen activator, urokinase receptor	Homo sapiens	33-37
18209068-4	2008	Arg261 of beta3 was mutated to Ala or Glu; the corresponding Lys252 of beta2 was mutated to Ala, Arg, Glu, Asp, or Phe; and the effects on heterodimer formation in each integrin examined by ELISA and immunoprecipitation in HEK 293 cells cotransfected with plasmids encoding the alpha- and beta-subunits.	Arginine	0-3	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	10-15
10606512-1	1999	Employing deletion mutant proteins and fluorescein-labeled oligodeoxyribonucleotides in a fluorescence polarization assay, the nucleic acid binding site of the intermediate filament (IF) subunit protein vimentin was localized to the middle of the arginine-rich, non-alpha-helical, N-terminal head domain.	Arginine	247-255	vimentin	Homo sapiens	203-211
17693925-14	2008	In contrast, the hypothalamic levels of IL-10 were significantly elevated by L-arginine during heatstroke.	Arginine	77-87	interleukin 10	Rattus norvegicus	40-45
10590083-0	1999	The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts.	Arginine	37-40	H3 histone pseudogene 6	Homo sapiens	100-103
10606633-2	1999	Freshly isolated islets from IRS-1 knockout mice and SV40-transformed IRS-1-deficient beta-cell lines exhibit marked insulin secretory defects in response to glucose and arginine.	Arginine	170-178	insulin receptor substrate 1	Mus musculus	70-75
18068724-5	2008	In agreement with previous mutagenesis analyses, the Fab" interacts primarily with V3 through side-chain contacts with just two residues, Ile(P309) and Arg(P315), while the remaining contacts are to the main chain.	Arginine	152-155	FA complementation group B	Homo sapiens	53-56
17618629-6	2008	However, transcription of the insulin gene was activated only by extremely high concentrations of glucose and arginine added simultaneously.	Arginine	110-118	insulin	Oreochromis niloticus	30-37
10551833-8	1999	sqt-1 mutations that cause right-handed helical twisting affect conserved arginines in a predicted cleavage site for a subtilisin-like protease.	Arginine	74-83	Cuticle collagen sqt-1	Caenorhabditis elegans	0-5
17998208-7	2008	Recombinant metacaspase-8 cleaved after arginine, had a pH optimum of 8, and complemented the H(2)O(2) no-death phenotype of a yeast metacaspase knock-out.	Arginine	40-48	metacaspase 8	Arabidopsis thaliana	12-25
10510338-8	1999	Leptin-induced 5-HT increase was antagonized by the coadministration of L-arginine only when the latter was ICV injected, whereas D-arginine did not influence leptin effects on brain 5-HT content.	Arginine	72-82	leptin	Mus musculus	0-6
10510338-10	1999	Our results indicate that the L-arginine/NO pathway is involved in mediating leptin effects on feeding behavior, and demonstrate that nNOS activity is required for the effects of leptin on brain 5-HT turnover.	Arginine	30-40	leptin	Mus musculus	77-83
10672519-10	1999	Moreover, we show that residues Arg-37, Glu-52, Asp-56, Arg-73, and Arg-74 are involved in this interaction with the myosin rod.	Arginine	32-35	myosin heavy chain 14	Homo sapiens	117-123
18067274-9	2008	The arginine/serine rich domain at the N-terminus of Neurospora U2AF65 regulates its RNA binding.	Arginine	4-12	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	64-70
10672519-10	1999	Moreover, we show that residues Arg-37, Glu-52, Asp-56, Arg-73, and Arg-74 are involved in this interaction with the myosin rod.	Arginine	56-59	myosin heavy chain 14	Homo sapiens	117-123
10672519-10	1999	Moreover, we show that residues Arg-37, Glu-52, Asp-56, Arg-73, and Arg-74 are involved in this interaction with the myosin rod.	Arginine	56-59	myosin heavy chain 14	Homo sapiens	117-123
17948239-1	2008	The peptidylarginine deiminase (PAD) family of enzymes are responsible for conversion of protein-bound arginine to citrulline in most tissues of the body and are garnering increased interest for their physiological and pathological roles.	Arginine	12-20	peptidyl arginine deiminase 4	Homo sapiens	32-35
10500099-3	1999	Luc7p is similar in sequence to metazoan proteins that have arginine-serine and arginine-glutamic acid repeat sequences characteristic of a family of splicing factors.	Arginine	60-68	Luc7p	Saccharomyces cerevisiae S288C	0-5
10500099-3	1999	Luc7p is similar in sequence to metazoan proteins that have arginine-serine and arginine-glutamic acid repeat sequences characteristic of a family of splicing factors.	Arginine	80-88	Luc7p	Saccharomyces cerevisiae S288C	0-5
18156399-0	2008	Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis.	Arginine	0-8	ribosomal protein S6 kinase B1	Homo sapiens	34-37
10556563-7	1999	Lebetase I cleaves between Arg(696)-Leu(697), which is one of the most common cleavage sites in alpha(2)M by proteinases.	Arginine	27-30	alpha-2-macroglobulin	Homo sapiens	96-105
18156399-2	2008	In this study, we hypothesized that during rotavirus infection, oral Arg, which stimulates p70(S6k) activation, will further stimulate intestinal protein synthesis and mucosal recovery, whereas the p70(S6k) inhibitor rapamycin (Rapa) will inhibit mucosal recovery.	Arginine	69-72	ribosomal protein S6 kinase B1	Homo sapiens	95-98
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Arginine	243-251	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	0-4
18156399-2	2008	In this study, we hypothesized that during rotavirus infection, oral Arg, which stimulates p70(S6k) activation, will further stimulate intestinal protein synthesis and mucosal recovery, whereas the p70(S6k) inhibitor rapamycin (Rapa) will inhibit mucosal recovery.	Arginine	69-72	ribosomal protein S6 kinase B1	Homo sapiens	91-98
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Arginine	243-251	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Arginine	243-251	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
18156399-10	2008	However, in Arg-treated piglets, p70(S6k) activation occurred over the entire villus.	Arginine	12-15	ribosomal protein S6 kinase B1	Homo sapiens	37-40
10446428-4	1999	GPAT was expressed in Sf21 insect cells, and specific inhibitors strongly suggest that, like the Escherichia coli GPAT, the recombinant mitochondrial GPAT and the mitochondrial GPAT isoform in rat liver contain critical serine, histidine, and arginine residues.	Arginine	243-251	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	114-118
18156399-12	2008	We conclude that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70(S6k)-independent mechanism.	Arginine	48-51	ribosomal protein S6 kinase B1	Homo sapiens	135-138
18156399-12	2008	We conclude that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70(S6k)-independent mechanism.	Arginine	48-51	ribosomal protein S6 kinase B1	Homo sapiens	131-138
18773861-6	2008	However, in gene-gene interaction, EGFR 497Arg/Arg*EGF +61A/A showed significant risk for EC (OR 2.47, p = 0.011).	Arginine	43-46	epidermal growth factor	Homo sapiens	35-38
10439474-5	1999	These results suggest that the arginine residue 120 in the alpha 1 subtype of the GABAA receptor is essential for GABA binding.	Arginine	31-39	adrenoceptor alpha 1D	Homo sapiens	59-66
18085359-5	2008	L-Arginine further significantly increased MDA and NO, and decreased VEGF (P &lt; 0.05 vs aortic IR).	Arginine	0-10	vascular endothelial growth factor A	Rattus norvegicus	69-73
10393093-7	1999	These results provide the first direct measurement of the affinity of sialoadhesin for sialosides and confirm the critical importance of the conserved arginine in interactions between sialosides and members of the siglec family of sialic acid-binding, immunoglobulin-like lectins.	Arginine	151-159	sialic acid binding Ig like lectin 1	Homo sapiens	70-82
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Arginine	113-121	adrenoceptor alpha 1D	Homo sapiens	62-69
10395903-7	1999	The conserved mammalian cell-attachment signal Arg-Gly-Asp is absent in the caiman DMP1.	Arginine	47-50	dentin matrix acidic phosphoprotein 1	Homo sapiens	83-87
10383917-8	1999	In particular, CYP2C19, CYP2B6, CYP2C9-Arg, CYP2D6-Val, and CYP3A4 all showed relatively high activity.	Arginine	39-42	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	32-38
10467730-1	1999	Aminopeptidase B (EC 3.4.11.6) is a Zn(2+)-dependent exopeptidase which selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates including Arg0-Leu-enkephalin, Arg0-Met-enkephalin and Arg-1-Lys0-somatostatin-14.	Arginine	92-100	arginyl aminopeptidase	Rattus norvegicus	0-16
20641675-11	2004	A synthetic peptide (Arg-Glu-Asn-Leu-Arg-Ile-Ala-Leu-Arg-Tyr, B2702-p) corresponding to residues 75-84 of HLA-B2702 was shown to bind specifically to VCAM-1 (9).	Arginine	37-40	major histocompatibility complex, class I, B	Homo sapiens	106-111
17962409-0	2007	Galpha Gbetagamma dissociation may be due to retraction of a buried lysine and disruption of an aromatic cluster by a GTP-sensing Arg Trp pair.	Arginine	130-133	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	0-6
10431034-2	1999	In addition to its effects when administered as a dietary supplement, the end-products of arginine metabolism by the enzymes arginase, arginine decarboxylase (ADC), and nitric oxide synthase (NOS) have been shown to play roles in wound healing, immune response, tumor biology, and the regulation of inflammation.	Arginine	90-98	antizyme inhibitor 2	Homo sapiens	135-157
17962409-7	2007	These constraints are explained by a proposed mechanism for GTP-induced dissociation of Galpha from Gbetagamma where an Arg-Trp pair senses the presence of bound GTP leading to conformational retraction of a nearby lysine and to disruption of an aromatic cluster.	Arginine	120-123	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	88-94
17626108-2	2007	The substitution of tryptophan 64 with arginine (Trp64Arg) polymorphism (Arg variant) of the beta(3)-adrenergic receptor (ADRB3) has been associated with obesity.	Arginine	54-57	adrenoceptor beta 3	Homo sapiens	93-120
10329657-2	1999	Using alanine scanning mutagenesis, the role in receptor activation of charged amino acids (Asp, Glu, Lys, and Arg) and cysteines in the extracellular loops (EL) of the human P2Y1 receptor has been investigated.	Arginine	111-114	purinergic receptor P2Y1	Homo sapiens	175-188
17626108-2	2007	The substitution of tryptophan 64 with arginine (Trp64Arg) polymorphism (Arg variant) of the beta(3)-adrenergic receptor (ADRB3) has been associated with obesity.	Arginine	54-57	adrenoceptor beta 3	Homo sapiens	122-127
17626108-9	2007	The presence of the arginine 64 allele of the beta(3)-adrenergic receptor gene does not increase the risk of obstructive sleep apnoea syndrome, but is associated with the development of obesity in those patients who suffer obstructive sleep apnoea syndrome.	Arginine	20-28	adrenoceptor beta 3	Homo sapiens	46-73
10350488-0	1999	Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants.	Arginine	159-162	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	54-86
17941496-6	2007	The authors report the case of a 17-year-old girl who had a severe cyanotic cardiac malformation for which surgery was not advised and a heterozygous missense mutation (c.406T&gt;C) in exon 5 of PTEN resulting in the substitution of cysteine for arginine (p.Cysl36Arg) in the protein, which was also found in her mother and sister.	Arginine	246-254	phosphatase and tensin homolog	Homo sapiens	195-199
10350488-7	1999	The Torpedo nAChR delta-subunit residue corresponding to gamma Tyr-111 (delta Arg-113) contains a positive charge which could confer the lower binding affinity seen for some competitive antagonists at the alpha-delta agonist site.	Arginine	78-81	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	12-17
10401710-13	1999	From a diagnostic point of view, HEX 1 + HEX 2 was the association with the largest percentage of false positives (20% in FSS, 27% in CGD and 33% in NSD), HEX 1 +GHRH+PD resulted in 9% in CGD, while the combined use of HEX 1 or HEX 2 with GHRH+PD or ARG+EE and of GHRH+PD with ARG+EE did not show false positive responses.	Arginine	250-253	exonuclease 1	Homo sapiens	155-160
10401710-13	1999	From a diagnostic point of view, HEX 1 + HEX 2 was the association with the largest percentage of false positives (20% in FSS, 27% in CGD and 33% in NSD), HEX 1 +GHRH+PD resulted in 9% in CGD, while the combined use of HEX 1 or HEX 2 with GHRH+PD or ARG+EE and of GHRH+PD with ARG+EE did not show false positive responses.	Arginine	250-253	exonuclease 1	Homo sapiens	155-160
17612583-1	2007	In species of the genus Nicotiana, as in most plants, the important polyamine precursor putrescine can be derived from the amino acids ornithine and/or arginine via the activity of ornithine decarboxylase (ODC) and/or arginine decarboxylase (ADC), respectively.	Arginine	152-160	ornithine decarboxylase	Nicotiana tabacum	181-204
10401710-13	1999	From a diagnostic point of view, HEX 1 + HEX 2 was the association with the largest percentage of false positives (20% in FSS, 27% in CGD and 33% in NSD), HEX 1 +GHRH+PD resulted in 9% in CGD, while the combined use of HEX 1 or HEX 2 with GHRH+PD or ARG+EE and of GHRH+PD with ARG+EE did not show false positive responses.	Arginine	277-280	exonuclease 1	Homo sapiens	155-160
10401710-13	1999	From a diagnostic point of view, HEX 1 + HEX 2 was the association with the largest percentage of false positives (20% in FSS, 27% in CGD and 33% in NSD), HEX 1 +GHRH+PD resulted in 9% in CGD, while the combined use of HEX 1 or HEX 2 with GHRH+PD or ARG+EE and of GHRH+PD with ARG+EE did not show false positive responses.	Arginine	277-280	exonuclease 1	Homo sapiens	155-160
10217293-6	1999	The site of cleavage, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry, is N-terminal to the Arg at the P1 position for the dynorphin converting enzyme and C-terminal to the Arg at the P1 position for furin and prohormone convertase 1.	Arginine	138-141	proprotein convertase subtilisin/kexin type 1	Homo sapiens	256-279
10217293-6	1999	The site of cleavage, as determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry, is N-terminal to the Arg at the P1 position for the dynorphin converting enzyme and C-terminal to the Arg at the P1 position for furin and prohormone convertase 1.	Arginine	219-222	proprotein convertase subtilisin/kexin type 1	Homo sapiens	256-279
10187828-6	1999	By reverse transcriptase-polymerase chain reaction and sequence analysis, G to A point mutations were identified in CEM/Mtx-1 transcripts at positions 130 (P1; changes glycine 44 --&gt; arginine) and 380 (P2; changes serine 127 --&gt; asparagine).	Arginine	186-194	metaxin 1	Homo sapiens	120-125
10092646-4	1999	CDKs have been shown to have a high preference for a basic residue (lysine or arginine) as the n+3 residue, n being the location in the primary sequence of a phosphoacceptor serine or threonine.	Arginine	78-86	cyclin dependent kinase 5	Homo sapiens	0-4
10213479-5	1999	Immediately after subjecting the animals to hyperthermia, a minor reduction (16%) in the acceptor capacity of [14C]-arginine into proteins was observed in comparison with animals maintained at 28 degrees C. However, in the animals allowed to recover for 3 h, an increase (46%) in the arginylation was observed concomitantly with a significant accumulation of the heat shock protein (70 kDa; hsp 70) when compared to the control animals.	Arginine	116-124	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	363-397
10092106-8	1999	This high homology together with the presence of a charged amino acid (Arg) in the transmembrane portion suggest that MAR-1 may associate at the cell membrane into a multimeric complex with ITAM containing polypeptides.	Arginine	71-74	retrotransposon Gag like 1	Homo sapiens	118-123
9987991-3	1999	Furthermore, L-arginine, the required precursor for nitric oxide synthesis, is an excellent NBAT substrate.	Arginine	13-23	solute carrier family 3 member 1	Rattus norvegicus	92-96
9952163-10	1999	gas-1(fc21) is a missense mutation replacing a strictly conserved arginine with lysine.	Arginine	66-74	putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	Caenorhabditis elegans	0-5
10051761-6	1999	The arginine stems from post-transcriptional editing of the GluR5 and GluR6 pre-RNAs, and the unedited and edited versions of GluR6 elicit distinct Ca2+ permeability.	Arginine	4-12	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	60-65
9892210-3	1999	First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, but that the standard form of CD44 does not.	Arginine	77-85	secreted phosphoprotein 1	Homo sapiens	67-70
9892210-4	1999	These CD44 variants bind to both the amino- and COOH-terminal portions of OPN independently of the arginine-glycine-aspartic acid sequence, suggesting that multiple domains on OPN can be bound by the CD44 variants.	Arginine	99-107	secreted phosphoprotein 1	Homo sapiens	74-77
9890404-6	1999	The P-selectin expression on the platelet surface in whole blood was reduced by ISDN and L-arginine.	Arginine	89-99	selectin P	Homo sapiens	4-14
10072711-3	1999	None of these autacoids play such a central role in the regulation of vascular tone and homeostasis as the primary EDRF, the free radical NO, which is generated via a live-electron oxidation of a guanidino nitrogen from L-arginine by an NO synthase (NOS).	Arginine	220-230	alpha hemoglobin stabilizing protein	Homo sapiens	115-119
10210178-6	1999	The structure reveals that the WSDWS motif of gp130 is part of an extended tryptophan/arginine zipper which modulates the conformation of the CD loop.	Arginine	86-94	interleukin 6 cytokine family signal transducer	Homo sapiens	46-51
9857182-5	1998	The ability of the RV glycoprotein to bind p75NTR was dependent on the presence of a lysine and arginine in positions 330 and 333 respectively of antigenic site III, which is known to control virus penetration into motor and sensory neurons of adult mice.	Arginine	96-104	nerve growth factor receptor	Homo sapiens	43-49
9851783-4	1998	In the present work, we describe an already known mutation in a new patient affected by apparent mineralocorticoid excess, which results in an arginine-to-cysteine mutation (R213C) in the 11betaHSD2 enzyme.	Arginine	143-151	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	188-198
9875639-8	1998	Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production.	Arginine	225-235	interferon gamma	Rattus norvegicus	0-16
9875639-9	1998	CONCLUSIONS: In transformed hepatic stellate cells, tumor necrosis factor-alpha and interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible nitric oxide synthase expression are regulated in a differential cytokine-specific manner.	Arginine	167-177	interferon gamma	Rattus norvegicus	84-100
9819417-4	1998	We found that expression of E3 in yeast overcomes the lethal effect of PKR in a manner requiring key residues (Lys-167 and Arg-168) needed for dsRNA binding by E3 in vitro.	Arginine	123-126	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	71-74
9819417-9	1998	In yeast two-hybrid assays and in vitro protein binding experiments, segments of E3 and PKR containing their respective DRBMs interacted in a manner requiring E3 residues Lys-167 and Arg-168.	Arginine	183-186	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	88-91
10209938-1	1998	BACKGROUND: The authors carried out a study on the simultaneous modifications of nitrite, endothelin and E-selectin plasma levels after infusion of arginine (a precursor of nitric oxide endothelial synthesis) in normal and vasculopathic subjects.	Arginine	148-156	selectin E	Homo sapiens	105-115
9837751-5	1998	DNA sequencing analysis disclosed a missense mutation from CTG (Leu) to CGG (Arg) at codon 352 located within the sixth transmembrane domain of octn2.	Arginine	77-80	solute carrier family 22 (organic cation transporter), member 5	Mus musculus	144-149
9806879-2	1998	Of the enzymes that catalyse rate-controlling steps in arginine synthesis and catabolism, argininosuccinate synthase, the two arginase isoenzymes, the three nitric oxide synthase isoenzymes and arginine decarboxylase have been recognized in recent years as key factors in regulating newly identified aspects of arginine metabolism.	Arginine	55-63	argininosuccinate synthase 1	Homo sapiens	90-116
9806879-2	1998	Of the enzymes that catalyse rate-controlling steps in arginine synthesis and catabolism, argininosuccinate synthase, the two arginase isoenzymes, the three nitric oxide synthase isoenzymes and arginine decarboxylase have been recognized in recent years as key factors in regulating newly identified aspects of arginine metabolism.	Arginine	55-63	antizyme inhibitor 2	Homo sapiens	194-216
9806879-3	1998	In particular, changes in the activities of argininosuccinate synthase, the arginases, the inducible isoenzyme of nitric oxide synthase and also cationic amino acid transporters play major roles in determining the metabolic fates of arginine in health and disease, and recent studies have identified complex patterns of interaction among these enzymes.	Arginine	233-241	argininosuccinate synthase 1	Homo sapiens	44-70
9861541-5	1998	The response of insulin after arginine injection was smaller in the hot compared with the thermoneutral environment; however, arginine injection resulted in a significantly higher secretion of glucagon in the hot environment.	Arginine	30-38	insulin	Bos taurus	16-23
9833913-8	1998	We also analyzed the effect of Arg-Gly-Asp containing peptides on the expression of smooth muscle alpha actin by immunocytochemistry and immunoblotting.	Arginine	31-34	actin alpha 2, smooth muscle	Rattus norvegicus	84-109
9765407-2	1998	We report here the expression of soluble integrin alphav beta5, which retains the ability to recognize the Ad penton base as well as vitronectin, an Arg Gly Asp (RGD)-containing extracellular matrix protein.	Arginine	149-152	adaptor related protein complex 5 subunit beta 1	Homo sapiens	57-62
9811002-15	1998	Neutrophil counts and myeloperoxidase activity after 4 hours of reperfusion were significantly higher in ischemia-reperfusion flaps treated with L-NAME and L-arginine as compared with the other three groups (p &lt; 0.05).	Arginine	156-166	myeloperoxidase	Sus scrofa	22-37
10397478-1	1998	L-Canavanine (L-CAV) is a naturally occurring L-arginine analog that induces the formation of non-functional proteins in a variety of organisms.	Arginine	46-56	caveolin 2	Homo sapiens	16-19
9774386-2	1998	We tested the role of processing by creating a mutant in which the P1 residue (Arg3942) of the consensus site for furin cleavage (Arg-Asn-Arg-Arg3942 downward arrow) was replaced with Ser in chicken LRP.	Arginine	79-82	furin, paired basic amino acid cleaving enzyme	Gallus gallus	114-119
9774386-2	1998	We tested the role of processing by creating a mutant in which the P1 residue (Arg3942) of the consensus site for furin cleavage (Arg-Asn-Arg-Arg3942 downward arrow) was replaced with Ser in chicken LRP.	Arginine	130-133	furin, paired basic amino acid cleaving enzyme	Gallus gallus	114-119
9756897-2	1998	The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, and a P6 Ile and a P4 Arg were most inhibitory against PC2.	Arginine	49-52	proprotein convertase subtilisin/kexin type 1	Homo sapiens	106-109
9756897-2	1998	The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, and a P6 Ile and a P4 Arg were most inhibitory against PC2.	Arginine	73-76	proprotein convertase subtilisin/kexin type 1	Homo sapiens	106-109
9756897-2	1998	The library surveys revealed that a P6 Leu, a P4 Arg, a P2 Lys, and a P1 Arg were most inhibitory against PC1, and a P6 Ile and a P4 Arg were most inhibitory against PC2.	Arginine	73-76	proprotein convertase subtilisin/kexin type 2	Homo sapiens	166-169
9770425-2	1998	The natural cleavage of VP2 to VP3 in CPV full (DNA containing) particles recovered from tissue culture occurred within the sequence Arg-Asn-Glu-Arg Ala-Thr.	Arginine	133-136	VP2	Canine parvovirus	24-27
9770425-2	1998	The natural cleavage of VP2 to VP3 in CPV full (DNA containing) particles recovered from tissue culture occurred within the sequence Arg-Asn-Glu-Arg Ala-Thr.	Arginine	145-148	VP2	Canine parvovirus	24-27
9760244-6	1998	Edman sequencing of peptides S1 and S2 of sheep SHBG showed a same single sequence corresponding to residues Gln-126-Arg-140 which contained no identifiable phenylthiohydantoin derivative at cycle 14, thus indicating that in both cases the corresponding Met-139 residue is the main site of photolabeling, as confirmed for peptide S1 by the presence at this cycle of a major peak of radioactivity while in peptide S2 the photoattachment of Delta 6-testosterone was found labile in the conditions of sequencing.	Arginine	117-120	sex hormone-binding globulin	Ovis aries	48-52
9751083-6	1998	L-Arginine treatment protected the liver partially from the elevation of collagen, bilirubins, and alkaline phosphatase and from glycogen depletion induced by CCl4 intoxication (P &lt; 0.05), but showed no significant effect on ALT, gamma-GTP, or lipid peroxidation.	Arginine	0-10	gamma-glutamyltransferase 1	Rattus norvegicus	233-242
9760183-6	1998	Arginine residue mutations in Chs3p, and in Chs1p and Chs2p, resulted in a loss of both function in vivo and enzymatic activity.	Arginine	0-8	chitin synthase CHS2	Saccharomyces cerevisiae S288C	54-59
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Arginine	137-140	fibronectin 1	Mus musculus	86-88
9727075-2	1998	We have previously found that mouse hematopoietic stem cells could be transduced on a FN fragment that included the recognition sequence Arg-Gly-Asp (RGD), suggesting that stem cells may express the integrin very late antigen (VLA)-5.	Arginine	137-140	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	208-233
17612583-1	2007	In species of the genus Nicotiana, as in most plants, the important polyamine precursor putrescine can be derived from the amino acids ornithine and/or arginine via the activity of ornithine decarboxylase (ODC) and/or arginine decarboxylase (ADC), respectively.	Arginine	152-160	ornithine decarboxylase	Nicotiana tabacum	206-209
17693144-3	2007	It had previously been proposed that the arginine residue (R17) in the loop I region of the Pin1 WW domain is essential for binding to the pSer/pThr-Pro motifs of phosphorylated ligands such as Cdc25c.	Arginine	41-49	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	92-96
9792029-5	1998	Inhibition of NO production by the addition of L-arginine antagonists to the culture, partially cancelled such an inhibitory effect of LPS and/or IFNgamma on DNA synthesis without affecting the activation of AP-1 and NF-kappaB and the NO synthase level.	Arginine	47-57	interferon gamma	Rattus norvegicus	146-154
17693144-3	2007	It had previously been proposed that the arginine residue (R17) in the loop I region of the Pin1 WW domain is essential for binding to the pSer/pThr-Pro motifs of phosphorylated ligands such as Cdc25c.	Arginine	41-49	cell division cycle 25C	Homo sapiens	194-200
28976688-5	1998	Inhibition of NO production by the addition of L-arginine antagonists to the culture, partially cancelled such an inhibitory effect of LPS and/or IFNgamma on DNA synthesis without affecting the activation of AP-1 and NF-kappaB and the NO synthase level.	Arginine	47-57	interferon gamma	Rattus norvegicus	146-154
17693144-4	2007	In PinA, a fungal homologue of Pin1, the arginine residue (R17) is replaced with an asparagine residue (N17).	Arginine	41-49	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
17604274-10	2007	Additional enzyme studies demonstrated that FucT-VI has approximately 12-fold higher activity compared with FucT-V and that the Trp(124)/Arg(110) site in these enzymes is responsible primarily for this activity difference.	Arginine	137-140	fucosyltransferase 6	Homo sapiens	44-51
9739038-1	1998	BACKGROUND: A combination of epidermal growth factor (EGF) and human growth hormone (hGH) after massive enterectomy induces a 400% increase in arginine transport in the remnant distal small intestine.	Arginine	143-151	epidermal growth factor	Homo sapiens	29-52
9739038-1	1998	BACKGROUND: A combination of epidermal growth factor (EGF) and human growth hormone (hGH) after massive enterectomy induces a 400% increase in arginine transport in the remnant distal small intestine.	Arginine	143-151	epidermal growth factor	Homo sapiens	54-57
9739038-11	1998	A combination of EGF and hGH after massive enterectomy increase arginine transport by Vmax upregulation in both the high-capacity/low-affinity and low-capacity/high-affinity systems.	Arginine	64-72	epidermal growth factor	Homo sapiens	17-20
9693114-5	1998	Depletion of arginine, cystine and all essential amino acids leads to induction of IGFBP-1 mRNA and protein expression in a dose-dependent manner.	Arginine	13-21	insulin like growth factor binding protein 1	Homo sapiens	83-90
17496212-3	2007	In this report, evidence is provided demonstrating that treatment with TNF-alpha (10 ng/ml) suppresses not only eNOS expression but also the availability of arginine via the coordinate suppression of argininosuccinate synthase (AS) expression in aortic endothelial cells.	Arginine	157-165	argininosuccinate synthase 1	Homo sapiens	200-226
9683440-6	1998	The NO donor diethylenetriamine/NO and L-arginine were both effective in attenuating the gut I/R-induced increases in rolling leukocytes (in THV) and P-selectin expression (in liver, intestine, and lung).	Arginine	39-49	selectin P	Homo sapiens	150-160
17496212-3	2007	In this report, evidence is provided demonstrating that treatment with TNF-alpha (10 ng/ml) suppresses not only eNOS expression but also the availability of arginine via the coordinate suppression of argininosuccinate synthase (AS) expression in aortic endothelial cells.	Arginine	157-165	argininosuccinate synthase 1	Homo sapiens	228-230
17540775-5	2007	Residue Arg(346) was a critical recognition element on PAI-1 for interaction with FSAP.	Arginine	8-11	serpin family E member 1	Homo sapiens	55-60
9694932-0	1998	Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice.	Arginine	23-33	interleukin 5	Mus musculus	101-114
9694932-7	1998	L-Arginine also increased protein levels of IL-5 and IL-2 in supernatants from the lung exposed to ovalbumin.	Arginine	0-10	interleukin 5	Mus musculus	44-48
9694932-7	1998	L-Arginine also increased protein levels of IL-5 and IL-2 in supernatants from the lung exposed to ovalbumin.	Arginine	0-10	interleukin 2	Mus musculus	53-57
9694932-11	1998	administration of L-arginine aggravates allergen-induced eosinophilic airway inflammation via expression of IL-5, and in this model it does not show therapeutic efficacy against airway hyperresponsiveness associated with allergen exposure.	Arginine	18-28	interleukin 5	Mus musculus	108-112
9742571-4	1998	Molecular analysis of the affected son revealed a G to A mutation in codon 156 of keratin 10, resulting in an arginine to histidine substitution within the highly conserved 1A region.	Arginine	110-118	keratin 10	Homo sapiens	82-92
17540775-9	2007	Residues Arg(76) and Lys(80) in PAI-1 were key elements mediating binding of nucleic acids to PAI-1.	Arginine	9-12	serpin family E member 1	Homo sapiens	32-37
17540775-9	2007	Residues Arg(76) and Lys(80) in PAI-1 were key elements mediating binding of nucleic acids to PAI-1.	Arginine	9-12	serpin family E member 1	Homo sapiens	94-99
17343889-2	2007	While previous studies of Fv1 restriction involving N- and B-tropic murine leukemia viruses (MLVs) had demonstrated that the identity of a single amino acid residue at CA110 (arginine vs. glutamic acid) determines whether the resulting virus is N (arg) or B-tropic (glu), analogous studies of dual-tropic MLVs, such as Moloney MLV (Mo-MLV), have shown that additional residues other than CA110 are also involved in the specification of dual-tropic host range.	Arginine	175-183	Friend virus susceptibility 1	Mus musculus	26-29
17343889-2	2007	While previous studies of Fv1 restriction involving N- and B-tropic murine leukemia viruses (MLVs) had demonstrated that the identity of a single amino acid residue at CA110 (arginine vs. glutamic acid) determines whether the resulting virus is N (arg) or B-tropic (glu), analogous studies of dual-tropic MLVs, such as Moloney MLV (Mo-MLV), have shown that additional residues other than CA110 are also involved in the specification of dual-tropic host range.	Arginine	175-178	Friend virus susceptibility 1	Mus musculus	26-29
9675278-10	1998	In particular, Met8--&gt;Arg substitution at P3", which increased association constant for chymotrypsin 46-fold, led to a 7-fold decrease of binding with cathepsin G.	Arginine	25-28	cathepsin G	Homo sapiens	154-165
17466295-0	2007	Role for Btg1 and Btg2 in growth arrest of WEHI-231 cells through arginine methylation following membrane immunoglobulin engagement.	Arginine	66-74	BTG anti-proliferation factor 1	Mus musculus	9-13
9696046-9	1998	The EPHB2v protein lacks one arginine residue that resides immediately following the EPHB2 transmembrane domain.	Arginine	29-37	EPH receptor B2	Homo sapiens	4-10
9696046-9	1998	The EPHB2v protein lacks one arginine residue that resides immediately following the EPHB2 transmembrane domain.	Arginine	29-37	EPH receptor B2	Homo sapiens	4-9
17392035-8	2007	CONCLUSION: These results suggest that the Arg/Arg genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual"s susceptibility for brucella infection.	Arginine	43-46	selectin E	Homo sapiens	67-77
9703961-0	1998	Prohormone convertase 1 (PC1) when expressed with pro cholecystokinin (pro CCK) in L cells performs three endoproteolytic cleavages which are observed in rat brain and in CCK-expressing endocrine cells in culture, including the production of glycine and arginine extended CCK8.	Arginine	254-262	proprotein convertase subtilisin/kexin type 1	Homo sapiens	0-23
9703961-0	1998	Prohormone convertase 1 (PC1) when expressed with pro cholecystokinin (pro CCK) in L cells performs three endoproteolytic cleavages which are observed in rat brain and in CCK-expressing endocrine cells in culture, including the production of glycine and arginine extended CCK8.	Arginine	254-262	proprotein convertase subtilisin/kexin type 1	Homo sapiens	25-28
17392035-8	2007	CONCLUSION: These results suggest that the Arg/Arg genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual"s susceptibility for brucella infection.	Arginine	47-50	selectin E	Homo sapiens	67-77
17387163-4	2007	In this study, we provided several lines of evidence suggesting that IFN-gamma-mediated parasite growth enhancement was associated with L-arginine transport via mouse cationic amino acid transporter 2B (mCAT-2B).	Arginine	136-146	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	167-201
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	hematopoietic prostaglandin D synthase	Rattus norvegicus	14-39
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	hematopoietic prostaglandin D synthase	Rattus norvegicus	41-44
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	hematopoietic prostaglandin D synthase	Rattus norvegicus	184-187
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	264-268
17498268-8	2007	In AIF-1, RS2269475 exon 4A allele, which generates a nonsynonymous change (tryptophan to arginine), was significantly associated in patients with SSc (P= 0.0009) and was associated with those patients who had DcSSc (P= 0.002).	Arginine	90-98	allograft inflammatory factor 1	Homo sapiens	3-8
9785578-1	1998	"Arginine-glutamine trigger" in the fourth position of the central tetrapeptide of the V3 loop of gp120].	Arginine	1-9	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	98-103
9632653-4	1998	On this basis, the glutathione S-transferase (GST)-TatR49/52/53/55/56/57A mutant, in which six arginine residues within the basic domain of Tat were mutagenized to alanine residues, was compared with GST-Tat for its capacity to bind immobilized heparin.	Arginine	95-103	glutathione S-transferase kappa 1	Homo sapiens	19-44
17343823-4	2007	Among the genes identified, Orai1 contains a distinctive proline- and arginine-rich N-terminal cytoplasmic sequence.	Arginine	70-78	ORAI calcium release-activated calcium modulator 1	Mus musculus	28-33
9632653-4	1998	On this basis, the glutathione S-transferase (GST)-TatR49/52/53/55/56/57A mutant, in which six arginine residues within the basic domain of Tat were mutagenized to alanine residues, was compared with GST-Tat for its capacity to bind immobilized heparin.	Arginine	95-103	glutathione S-transferase kappa 1	Homo sapiens	46-49
17425781-1	2007	BACKGROUND: In microorganisms and plants, the first two reactions of arginine biosynthesis are catalyzed by N-acetylglutamate synthase (NAGS) and N-acetylglutamate kinase (NAGK).	Arginine	69-77	N-acetylglucosamine kinase	Homo sapiens	146-170
9611271-10	1998	Comparison of amino acid content revealed that BmP109 contained much more cysteine and lysine but less glycine and arginine than the antiapoptotic proteins.	Arginine	115-123	saposin-related	Bombyx mori	47-53
9618389-5	1998	Similarly, argininosuccinate lyase and argininosuccinate synthetase, both involved in the recycling of L-citrulline to L-arginine, were expressed at high levels in rat embryonic and neonatal diaphragms, with gradual reduction in their expression during late postnatal development.	Arginine	119-129	argininosuccinate lyase	Rattus norvegicus	11-34
17425781-1	2007	BACKGROUND: In microorganisms and plants, the first two reactions of arginine biosynthesis are catalyzed by N-acetylglutamate synthase (NAGS) and N-acetylglutamate kinase (NAGK).	Arginine	69-77	N-acetylglucosamine kinase	Homo sapiens	172-176
17303166-8	2007	A comparison of bovine histones either treated or untreated with PAD by amino acid analysis also supported the interference of deimination by arginine methylation.	Arginine	142-150	peptidyl arginine deiminase 4	Homo sapiens	65-68
17388440-9	2007	In addition, we also find that the alpha-helix is most stable at the AdP N-terminus where eight consecutive Ala occur, whereas the three hydrophilic Arg located in the middle and at the C-terminus destabilize the alpha-helix in these regions and induce defects such as pi-bulges and 3(10)-helices.	Arginine	149-152	WD and tetratricopeptide repeats 1	Homo sapiens	69-72
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Arginine	159-162	uncoupling protein 1	Homo sapiens	52-55
17303175-4	2007	Human CYP2C9-Arg expressed in the microsomes of human B lymphoblastoid cells efficiently catalyzed the 11-hydroxylation of Delta(8)-THC (7.60 nmol/min/nmol CYP), Delta(9)-THC (19.2 nmol/min/nmol CYP) and CBN (6.62 nmol/min/nmol CYP).	Arginine	13-16	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	6-12
17303175-4	2007	Human CYP2C9-Arg expressed in the microsomes of human B lymphoblastoid cells efficiently catalyzed the 11-hydroxylation of Delta(8)-THC (7.60 nmol/min/nmol CYP), Delta(9)-THC (19.2 nmol/min/nmol CYP) and CBN (6.62 nmol/min/nmol CYP).	Arginine	13-16	peptidylprolyl isomerase G	Homo sapiens	6-9
9616228-7	1998	Thus, (a) eNOS is a downstream mediator for in vivo angiogenesis, and (b) promoting eNOS activity by L-arginine supplementation accelerates in vivo angiogenesis.	Arginine	101-111	nitric oxide synthase 3, endothelial cell	Mus musculus	84-88
17303175-4	2007	Human CYP2C9-Arg expressed in the microsomes of human B lymphoblastoid cells efficiently catalyzed the 11-hydroxylation of Delta(8)-THC (7.60 nmol/min/nmol CYP), Delta(9)-THC (19.2 nmol/min/nmol CYP) and CBN (6.62 nmol/min/nmol CYP).	Arginine	13-16	peptidylprolyl isomerase G	Homo sapiens	156-159
17303175-4	2007	Human CYP2C9-Arg expressed in the microsomes of human B lymphoblastoid cells efficiently catalyzed the 11-hydroxylation of Delta(8)-THC (7.60 nmol/min/nmol CYP), Delta(9)-THC (19.2 nmol/min/nmol CYP) and CBN (6.62 nmol/min/nmol CYP).	Arginine	13-16	peptidylprolyl isomerase G	Homo sapiens	156-159
17204471-3	2007	By replacing this conserved aspartic acid residue with alanine, asparagine, glutamate, and arginine, we now show that this residue plays a crucial role in binding and signal transduction of NPY/PP at all YRs.	Arginine	91-99	neuropeptide Y	Homo sapiens	190-193
9657438-6	1998	In line with the experimental data, molecular modelling of the mutation based on the coordinates of the tissue factor/FVIIa complex showed that substituting arginine for glutamine disrupts the interface between the catalytic and second epidermal growth factor-like domains.	Arginine	157-165	coagulation factor III, tissue factor	Homo sapiens	104-117
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	73-81	neuropeptide Y	Homo sapiens	232-235
9576954-0	1998	CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120.	Arginine	56-64	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	87-92
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	143-146	neuropeptide Y	Homo sapiens	232-235
9572853-7	1998	By further proteolytic digestion after denaturation and reduction, it was also possible to degrade the PAI-1 moiety, and we isolated a fragment containing 10 amino acids from uPA, encompassing the active site Ser, and 6 amino acids from PAI-1, including the P1 Arg.	Arginine	261-264	serpin family E member 1	Homo sapiens	103-108
17204471-6	2007	Surprisingly, this conserved residue interacts with two different ligand arginine residues by ionic interactions; although in Y(2)R and Y(5)R, Arg(33) is the binding partner of Asp(6.59), in Y(1)R and Y(4)R, Arg(35) of human PP and NPY interacts with Asp(6.59).	Arginine	208-211	neuropeptide Y	Homo sapiens	232-235
17204471-7	2007	Furthermore, Arg(25) of PP and NPY is involved in ligand binding only at Y(2)R and Y(5)R. This suggests significant differences in the docking of YR ligands between Y(1/4)R and Y(2/5)R and provides new insights into the molecular binding mode of peptide agonists at GPCRs.	Arginine	13-16	neuropeptide Y	Homo sapiens	31-34
17250643-12	2007	The administration of either L-arginine or L-NAME into the CA1 region produced significant anxiogenic-like responses, whereas administration of AM251 induced anxiolytic effects.	Arginine	29-39	carbonic anhydrase 1	Rattus norvegicus	59-62
9581815-5	1998	Mutational analysis identified four BCCs with somatic missense mutations in SMOH affecting codon 535 (TGG==&gt;TTG: Trp==&gt;Leu) in three tumors and codon 199 (CGG==&gt;TGG: Arg==&gt;Trp) in one tumor.	Arginine	175-178	smoothened, frizzled class receptor	Homo sapiens	76-80
17493154-3	2007	At the protein level, these substitutions result in a change of a single amino acid residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg &gt; Pro) and 80 (Thr &gt; Ile), respectively.	Arginine	143-146	major histocompatibility complex, class I, B	Homo sapiens	103-108
17107794-0	2007	MCH-R1 antagonists based on an arginine scaffold: SAR studies on the amino-terminus.	Arginine	31-39	melanin concentrating hormone receptor 1	Homo sapiens	0-6
17107794-1	2007	We have identified a novel series of potent MCH-R1 antagonists based on l-arginine.	Arginine	72-82	melanin concentrating hormone receptor 1	Homo sapiens	44-50
17366317-7	2007	The entire coding region (exons 3-13) of the Bhd gene was sequenced, and a guanine (nt106G) to adenine (nt106A) polymorphism was detected resulting in a glycine to arginine (G36R) substitution in both tumor-bearing animals.	Arginine	164-172	folliculin	Rattus norvegicus	45-48
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Arginine	103-106	thyrotropin-releasing hormone	Oryzias latipes	11-16
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Arginine	107-110	thyrotropin-releasing hormone	Oryzias latipes	11-16
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Arginine	107-110	thyrotropin-releasing hormone	Oryzias latipes	11-16
17098236-2	2007	The medaka ppTRH cDNA codes for 270 amino acid residues including eight TRH progenitor sequences (-Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg-).	Arginine	107-110	thyrotropin-releasing hormone	Oryzias latipes	11-16
17210712-11	2007	Therefore, pretreatment tumor gene expression profiling of ASS and OTC could aid in predicting tumor response to arginine depletion with arginine-depleting enzymes.	Arginine	113-121	ornithine transcarbamylase	Homo sapiens	67-70
9602069-4	1998	The elevations of both proENK and proDYN mRNA levels induced by KA was effectively inhibited by pre-administration of L-ARG (400 mg/kg, i.p.	Arginine	118-123	proenkephalin	Rattus norvegicus	23-29
17210712-11	2007	Therefore, pretreatment tumor gene expression profiling of ASS and OTC could aid in predicting tumor response to arginine depletion with arginine-depleting enzymes.	Arginine	137-145	ornithine transcarbamylase	Homo sapiens	67-70
17507765-1	2007	Arginine rich, mutated in early stage of tumors (ARMET) was first identified as a human gene highly mutated in a variety of cancers.	Arginine	0-8	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	49-54
9602069-6	1998	The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.	Arginine	83-88	proenkephalin	Rattus norvegicus	27-33
21901069-6	2007	Although these 4 melanoma cell lines do not express ASS protein or mRNA as detected by both immunoblot and northernblot analysis, ASS protein can be induced after these cells are grown in the presence of ADI-PEG20, but again repressed after replenishing arginine in the media.	Arginine	254-262	argininosuccinate synthase 1	Homo sapiens	130-133
9602069-6	1998	The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.	Arginine	83-88	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	174-178
9589236-1	1998	OBJECTIVE: To assess the relevance of a Gly--&gt;Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.	Arginine	49-52	insulin receptor substrate 1	Homo sapiens	86-114
17283404-0	2007	Insulin and glucagon secretory patterns during propionate and arginine tolerance tests in Japanese black cattle with growth retardation.	Arginine	62-70	insulin	Bos taurus	0-7
9564049-3	1998	In the presence of ATP, hMutSalpha dissociated from mismatched oligonucleotide substrates, and this reaction was attenuated by mutating the conserved lysine in the ATP-binding domains of hMSH6, hMSH2 or both to arginine.	Arginine	211-219	mutS homolog 6	Homo sapiens	187-192
9589057-6	1998	Genetic testing for ret protooncogene mutation revealed a point mutation at codon 634 (Cys--&gt;Arg) in exon 11.	Arginine	96-99	ret proto-oncogene	Homo sapiens	20-23
17101798-1	2007	The activation of sex-specific alternative splice sites in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on the serine-arginine-rich (SR) splicing factors Tra, Tra2, and Rbp1.	Arginine	169-177	transformer	Drosophila melanogaster	205-208
9551089-0	1998	Role of arginine 86 of the insulin receptor in insulin binding and activation of glucose transport.	Arginine	8-16	insulin receptor	Cricetulus griseus	27-43
17146059-2	2006	Cleavage of the Tyr(1605)-Met(1606) scissile bond in the VWF A2 domain depends on a Glu(1660)-Arg(1668) segment in the same domain and on the noncatalytic spacer domain of ADAMTS13, suggesting that extensive enzyme-substrate interactions facilitate substrate recognition.	Arginine	94-97	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	172-180
9472028-4	1998	Random peptide selection for preferred phosphorylation sites revealed a stringent preference of SRPK2 for SR dipeptides, and the consensus derived may be used to predict potential phosphorylation sites in candidate arginine and serine-rich (RS) domain-containing proteins.	Arginine	215-223	SRSF protein kinase 2	Homo sapiens	96-101
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Arginine	123-126	epoxide hydrolase 1	Homo sapiens	100-104
9463405-0	1998	Association of phosphorylated serine/arginine (SR) splicing factors with the U1-small ribonucleoprotein (snRNP) autoantigen complex accompanies apoptotic cell death.	Arginine	37-45	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	105-110
9463405-6	1998	The U1-snRNP-associated phosphoprotein complex is immunoprecipitated by monoclonal antibodies reactive with serine/arginine (SR) proteins that comprise a structurally related family of splicing factors.	Arginine	115-123	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	7-12
17030622-6	2006	Structural modeling and mutation analysis reveal that, by constituting a steric clash that is masked upon binding Cbln1 in a "hide-and-run" mechanism of endoplasmic reticulum retention, a single arginine confers the unique properties of Cbln3.	Arginine	195-203	cerebellin 1 precursor protein	Mus musculus	114-119
9473309-6	1998	Based on these results, Ile-114, Arg-120, Ser-221, Ser-294, Ile-363, and Val-367 in cytochrome P450 2B4 were replaced simultaneously with Phe, His, Pro, Thr, Val, and Ala, respectively, from 2B5.	Arginine	33-36	cytochrome P450 2B4	Oryctolagus cuniculus	84-103
17030622-6	2006	Structural modeling and mutation analysis reveal that, by constituting a steric clash that is masked upon binding Cbln1 in a "hide-and-run" mechanism of endoplasmic reticulum retention, a single arginine confers the unique properties of Cbln3.	Arginine	195-203	cerebellin 3 precursor protein	Mus musculus	237-242
16980295-6	2006	In this study, the arginine fingers in RFC were mutated to examine the steps in the PCNA loading mechanism that occur after RFC binds ATP.	Arginine	19-27	proliferating cell nuclear antigen	Homo sapiens	84-88
9405297-1	1998	Aminopeptidase B (Ap-B) is a Zn2+-dependent exopeptidase which selectively removes Arg and/or Lys residues from the N terminus of several peptide substrates.	Arginine	83-86	arginyl aminopeptidase	Rattus norvegicus	0-16
9405297-1	1998	Aminopeptidase B (Ap-B) is a Zn2+-dependent exopeptidase which selectively removes Arg and/or Lys residues from the N terminus of several peptide substrates.	Arginine	83-86	arginyl aminopeptidase	Rattus norvegicus	18-22
17082006-9	2006	Studies on K562 cells showed that RPS19 mutations affecting RPS19 conserved arginines R56Q and R62Q could significantly inhibit the rate of protein synthesis, indicating the importance of RPS19 in translation.	Arginine	76-85	ribosomal protein S19	Homo sapiens	34-39
9539934-4	1998	RESULTS: A heterozygote T--&gt;C (Cys--&gt;Arg) mutation at codon 618 in exon 10 of the RET proto-oncogene was identified in 4 family members who had previously been diagnosed with medullary thyroid cancer.	Arginine	43-46	ret proto-oncogene	Homo sapiens	88-91
9399944-9	1997	In contrast, L-arginine treatment was associated with increased staining for Th2 cytokines IL-4 and IL-10.	Arginine	13-23	interleukin 10	Rattus norvegicus	100-105
17082006-9	2006	Studies on K562 cells showed that RPS19 mutations affecting RPS19 conserved arginines R56Q and R62Q could significantly inhibit the rate of protein synthesis, indicating the importance of RPS19 in translation.	Arginine	76-85	ribosomal protein S19	Homo sapiens	60-65
9550408-6	1997	Our data support the argument that V(H) CDR3 arginines tend to confer antimammalian dsDNA reactivity, leading to censure of B cells expressing these Abs and provides an explanation for the absence of arginine-rich V(H) CDR3 in the bacterial DNA-induced response.	Arginine	45-53	cerebellar degeneration-related 3	Mus musculus	40-44
17082006-9	2006	Studies on K562 cells showed that RPS19 mutations affecting RPS19 conserved arginines R56Q and R62Q could significantly inhibit the rate of protein synthesis, indicating the importance of RPS19 in translation.	Arginine	76-85	ribosomal protein S19	Homo sapiens	60-65
9550408-6	1997	Our data support the argument that V(H) CDR3 arginines tend to confer antimammalian dsDNA reactivity, leading to censure of B cells expressing these Abs and provides an explanation for the absence of arginine-rich V(H) CDR3 in the bacterial DNA-induced response.	Arginine	45-53	cerebellar degeneration-related 3	Mus musculus	219-223
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Arginine	142-145	MLO-like protein 4	Zea mays	73-104
16923966-4	2006	Methylation of SRC-3 was localized to an arginine in its CARM1 binding region and correlated with decreased estrogen receptor alpha-mediated transcription, as seen with both cell-based and in vitro transcription assays.	Arginine	41-49	nuclear receptor coactivator 3	Homo sapiens	15-20
16954377-7	2006	MRK preferentially phosphorylates R-P-X-S/T-P sites, with the preference for arginine at position -3 (P-3) being more stringent than for prolines at P-2 and P+1.	Arginine	77-85	ciliogenesis associated kinase 1	Homo sapiens	0-3
9522466-1	1997	Lys606, one of the two highly conserved lysine residues in maize C4-form phosphoenolpyruvate carboxylase (PEPC), was converted to Asn, Glu or Arg by site-directed mutagenesis.	Arginine	142-145	MLO-like protein 4	Zea mays	106-110
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Arginine	42-45	retinoic acid receptor alpha	Homo sapiens	186-214
9359845-8	1997	These results show that the N-terminal stretch of four consecutive arginine residues, Arg2-Arg3-Arg4-Arg5, has a decisive role in the interaction of hLF with heparin, lipid A, hLZ and DNA.	Arginine	67-75	HLF transcription factor, PAR bZIP family member	Homo sapiens	149-152
16916800-0	2006	Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.	Arginine	94-102	leucine decarboxylase 1	Mus musculus	6-34
9441729-9	1997	As known, MB has prominent effects on the nitrergic system; Nitric oxide (NO) produced from L-arginine by the enzyme NO-synthase (NOS) activates soluble guanylyl cyclase (sGC) and exerts its effects on tissues through cGMP.	Arginine	92-102	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	145-169
9441729-9	1997	As known, MB has prominent effects on the nitrergic system; Nitric oxide (NO) produced from L-arginine by the enzyme NO-synthase (NOS) activates soluble guanylyl cyclase (sGC) and exerts its effects on tissues through cGMP.	Arginine	92-102	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	171-174
16762971-7	2006	Sequencing of the Tpo gene of the dwarf mice demonstrated a C to T substitution at position 1508 causing an amino acid change from arginine (Arg) to cysteine (Cys) at codon 479 (Arg479Cys).	Arginine	131-139	thyroid peroxidase	Mus musculus	18-21
9347848-9	1997	RESULTS: Concomitant hGH and EGF treatment up-regulates glucose (100%), glutamine (80%), and leucine (60%) transport in the proximal remnant; alanine (150%) and arginine (400%) transport in the distal remnant; and microvillus height (25% to 35%) both proximally and distally.	Arginine	161-169	epidermal growth factor	Homo sapiens	29-32
16762971-7	2006	Sequencing of the Tpo gene of the dwarf mice demonstrated a C to T substitution at position 1508 causing an amino acid change from arginine (Arg) to cysteine (Cys) at codon 479 (Arg479Cys).	Arginine	141-144	thyroid peroxidase	Mus musculus	18-21
16980624-0	2006	Control of the DNA methylation system component MBD2 by protein arginine methylation.	Arginine	64-72	methyl-CpG binding domain protein 2	Homo sapiens	48-52
9305916-6	1997	A conserved arginine in FEN-1 (Arg339) and XPG (Arg992) was found to be crucial for PCNA binding activity.	Arginine	12-20	flap structure-specific endonuclease 1	Homo sapiens	24-29
9305916-6	1997	A conserved arginine in FEN-1 (Arg339) and XPG (Arg992) was found to be crucial for PCNA binding activity.	Arginine	12-20	proliferating cell nuclear antigen	Homo sapiens	84-88
16980624-6	2006	Here we report that the MBD2 protein is controlled by arginine methylation.	Arginine	54-62	methyl-CpG binding domain protein 2	Homo sapiens	24-28
16980624-7	2006	We identify the protein arginine methyltransferase enzymes that catalyze this modification and show that arginine methylation inhibits the function of MBD2.	Arginine	24-32	methyl-CpG binding domain protein 2	Homo sapiens	151-155
9404733-7	1997	Arginine-stimulated insulin secretion was also inhibited by somatostatin, and the effect was significantly potentiated with additional 10(-5) M IAPP.	Arginine	0-8	islet amyloid polypeptide	Rattus norvegicus	144-148
16980624-8	2006	Arginine methylation of MBD2 reduces MBD2-methyl-DNA complex formation, reduces MBD2-HDAC repression complex formation, and impairs the transcription repression function of MBD2 in cells.	Arginine	0-8	methyl-CpG binding domain protein 2	Homo sapiens	24-28
16980624-8	2006	Arginine methylation of MBD2 reduces MBD2-methyl-DNA complex formation, reduces MBD2-HDAC repression complex formation, and impairs the transcription repression function of MBD2 in cells.	Arginine	0-8	methyl-CpG binding domain protein 2	Homo sapiens	37-41
16980624-8	2006	Arginine methylation of MBD2 reduces MBD2-methyl-DNA complex formation, reduces MBD2-HDAC repression complex formation, and impairs the transcription repression function of MBD2 in cells.	Arginine	0-8	methyl-CpG binding domain protein 2	Homo sapiens	37-41
16980624-8	2006	Arginine methylation of MBD2 reduces MBD2-methyl-DNA complex formation, reduces MBD2-HDAC repression complex formation, and impairs the transcription repression function of MBD2 in cells.	Arginine	0-8	methyl-CpG binding domain protein 2	Homo sapiens	37-41
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	24-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	86-89	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
16899086-4	2006	Unexpectedly, however, these two interactions are not sufficient for Golgi targeting, as a third group of residues, including positive-charged arginine between alpha1 and alpha2 and hydrophobic residues C-terminal to the GRIP domain, turn out to be essential.	Arginine	143-151	adrenoceptor alpha 1D	Homo sapiens	160-177
16710051-5	2006	We conclude that mTOR/p70(s6k) signaling is essential to intestinal cell migration, is activated by ARG, involves both nuclear and cytoplasmic events, and may play a role in intestinal repair.	Arginine	100-103	ribosomal protein S6 kinase B1	Homo sapiens	22-29
9288945-0	1997	The biochemical effect of the naturally occurring Trp64--&gt;Arg mutation on human beta3-adrenoceptor activity.	Arginine	61-64	adrenoceptor beta 3	Homo sapiens	83-101
9234799-4	1997	Whereas furin has been shown to require arginine residues at positions -1 and -4 for substrate recognition, another protease with an activity which could substitute for furin in toxin activation, the furin-related protease PACE4, requires basic residues in the -1, -2, and -4 positions of the substrate sequence.	Arginine	40-48	furin	Cricetulus griseus	8-13
16740631-8	2006	In contrast, hK4, hK5, and less stringent hK6 displayed a trypsin-like specificity with strong preference for P1-Arg, whereas hK10 and hK11 showed an ambivalent specificity, accepting both basic and large aliphatic P1 residues.	Arginine	113-116	keratin 5	Homo sapiens	18-21
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Arginine	42-45	serpin family C member 1	Homo sapiens	140-145
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Arginine	50-53	serpin family C member 1	Homo sapiens	140-145
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Arginine	50-53	serpin family C member 1	Homo sapiens	140-145
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Arginine	50-53	serpin family C member 1	Homo sapiens	140-145
9235938-6	1997	The key heparin binding residues, Lys-11, Arg-13, Arg-24, Arg-47, Lys-125, Arg-129, and Arg-145, line a 50-A long channel on the surface of ATIII.	Arginine	50-53	serpin family C member 1	Homo sapiens	140-145
16458962-6	2006	The codon 72 polymorphism A2/A2 genotype (homozygous arginine) was associated with an increased susceptibility to CLL and CD38 negativity but did not appear to influence other biological behaviour or clinical response.	Arginine	53-61	CD38 molecule	Homo sapiens	122-126
16464493-3	2006	We established TEL-ARG and BCR-ABL fusion proteins as the mechanism underlying STAT5 phosphorylation in HT-93 and KBM-3 cells, respectively.	Arginine	19-22	signal transducer and activator of transcription 5A	Homo sapiens	79-84
19856281-0	1997	Heterogeneous nuclear RNP protein A1-arginine methylation during HCT-48 cell cycle.	Arginine	37-45	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	22-25
16652375-7	2006	Ki-ras mutations, which occurred chiefly in the K(s) allele (96%), were found in 79-81% of reciprocally crossed F1 mice, 64% of C mice, and 50% of B6 mice, with the Val(12), Asp(12), and Arg(13) mutations associated with more aggressive tumors.	Arginine	187-190	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-6
9243106-2	1997	The present study investigated in vivo lipolysis in individuals homozygous for the "variant" allele coding for arginine (Arg) in position 64 of the beta 3-adrenoceptor or homozygous for the "wild type" tryptophan (Trp) allele.	Arginine	111-119	adrenoceptor beta 3	Homo sapiens	148-167
9243106-2	1997	The present study investigated in vivo lipolysis in individuals homozygous for the "variant" allele coding for arginine (Arg) in position 64 of the beta 3-adrenoceptor or homozygous for the "wild type" tryptophan (Trp) allele.	Arginine	121-124	adrenoceptor beta 3	Homo sapiens	148-167
9260929-0	1997	Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.	Arginine	120-123	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-11
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	0-8	activating transcription factor 6	Rattus norvegicus	301-305
9260929-0	1997	Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion.	Arginine	120-123	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	22-26
9260929-2	1997	Previously, we have shown that the mature protein, formerly known as BA46, has three domains: an epidermal growth factor (EGF)-like domain containing an Arg-Gly-Asp (RGD) cell adhesion sequence and C1 and C2 domains similar to those found in coagulation factors V and VIII.	Arginine	153-156	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	69-73
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	159-167	activating transcription factor 6	Rattus norvegicus	301-305
16849482-2	2006	In the present study, we show that altering specific Arg residues in the H chain of a human pathogenic beta2GPI-dependent aPL, IS4, has major effects on its ability to bind these clinically important Ags.	Arginine	53-56	apolipoprotein H	Homo sapiens	103-111
9182708-11	1997	Parallel inhibition of the PI3Kgamma-associated protein kinase and lipid kinase by wortmannin and by the Lys-799--&gt;Arg mutation reveals that both activities are inherent in the PI3Kgamma polypeptide.	Arginine	118-121	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	27-36
9182708-11	1997	Parallel inhibition of the PI3Kgamma-associated protein kinase and lipid kinase by wortmannin and by the Lys-799--&gt;Arg mutation reveals that both activities are inherent in the PI3Kgamma polypeptide.	Arginine	118-121	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	180-189
16849482-10	2006	We hypothesize that these four Arg residues have developed as a result of somatic mutations driven by an Ag containing both PL and beta2GPI.	Arginine	31-34	apolipoprotein H	Homo sapiens	131-139
9171884-5	1997	The peptide Ac-Nle-c[Asp-His-Phe-Arg-D-Trp9-Ala-Lys]-NH2 demonstrated the greatest differentiation in binding affinity between the hMC1R and hMC4R (78-fold).	Arginine	33-36	melanocortin 1 receptor	Homo sapiens	131-146
16923367-12	2006	Low or high dose L-arginine treatment increased significantly the IGF-I levels from 0.789 +/- 0.062 ng/mg (Model group) to 0.937 +/- 0.067 ng/mg (low dose group) or 0.858 +/- 0.077 ng/mg (high dose group), the IGF-II levels from 0.270 +/- 0.020 ng/mg (Model group) to 0.318 +/- 0.018 ng/mg (low dose group) or 0.354 +/- 0.021 ng/mg (high dose group) and the IGF-I mRNA expression from (13.12 +/- 1.39) x 10(4) cps/mug RNA (Model group) to (19.24 +/- 2.48) x 10(4) cps/mug RNA (low dose group) or (17.35 +/- 2.30) x 10(4) cps/mug RNA (high dose group) (P &lt; 0.01).	Arginine	17-27	insulin-like growth factor 1	Rattus norvegicus	66-71
16923367-12	2006	Low or high dose L-arginine treatment increased significantly the IGF-I levels from 0.789 +/- 0.062 ng/mg (Model group) to 0.937 +/- 0.067 ng/mg (low dose group) or 0.858 +/- 0.077 ng/mg (high dose group), the IGF-II levels from 0.270 +/- 0.020 ng/mg (Model group) to 0.318 +/- 0.018 ng/mg (low dose group) or 0.354 +/- 0.021 ng/mg (high dose group) and the IGF-I mRNA expression from (13.12 +/- 1.39) x 10(4) cps/mug RNA (Model group) to (19.24 +/- 2.48) x 10(4) cps/mug RNA (low dose group) or (17.35 +/- 2.30) x 10(4) cps/mug RNA (high dose group) (P &lt; 0.01).	Arginine	17-27	insulin-like growth factor 1	Rattus norvegicus	210-215
16923367-13	2006	The IGFBP3 levels were significantly reduced after low or high dose L-arginine treatment (0.132 +/- 0.006 ng/mg or 0.146 +/- 0.009 ng/mg) compared with those of the Model group (0.253 +/- 0.011 ng/mg) ( P &lt; 0.01).	Arginine	68-78	insulin-like growth factor binding protein 3	Rattus norvegicus	4-10
16923367-14	2006	CONCLUSIONS: L-arginine can increase the levels of IGF-I and IGF-II and the IGF-I mRNA expression, and decrease the IGFBP3 level in the brain of rats with IUGR induced by passive smoking, thereby offering protective effects against IUGR.	Arginine	13-23	insulin-like growth factor 1	Rattus norvegicus	51-56
9177774-3	1997	Comparison of the human DMP1-coding sequence with that of the rat, mouse, and cow indicated that the predicted protein contains a conserved hydrophobic signal peptide sequence and an Arg-Gly-Asp cell attachment sequence.	Arginine	183-186	dentin matrix acidic phosphoprotein 1	Homo sapiens	24-28
16923367-14	2006	CONCLUSIONS: L-arginine can increase the levels of IGF-I and IGF-II and the IGF-I mRNA expression, and decrease the IGFBP3 level in the brain of rats with IUGR induced by passive smoking, thereby offering protective effects against IUGR.	Arginine	13-23	insulin-like growth factor 1	Rattus norvegicus	61-66
16923367-14	2006	CONCLUSIONS: L-arginine can increase the levels of IGF-I and IGF-II and the IGF-I mRNA expression, and decrease the IGFBP3 level in the brain of rats with IUGR induced by passive smoking, thereby offering protective effects against IUGR.	Arginine	13-23	insulin-like growth factor binding protein 3	Rattus norvegicus	116-122
17037076-2	2006	In fact, recent advanced studies have proved that arginine metabolism in wine malolactic bacteria is via arginine deiminase pathway (ADI pathway), and this pathway is composed of three enzymes: arginine deiminase (ADI), ornithine transcarbamylase (OTC), carbamate kinase (CK).	Arginine	50-58	ornithine transcarbamylase	Homo sapiens	220-246
17037076-2	2006	In fact, recent advanced studies have proved that arginine metabolism in wine malolactic bacteria is via arginine deiminase pathway (ADI pathway), and this pathway is composed of three enzymes: arginine deiminase (ADI), ornithine transcarbamylase (OTC), carbamate kinase (CK).	Arginine	50-58	ornithine transcarbamylase	Homo sapiens	248-251
16889683-7	2006	The patient was confirmed as having late-onset CTLN1 and treated with anticonvulsants, lactulose enema, protein restricted diet and arginine.	Arginine	132-140	argininosuccinate synthase 1	Homo sapiens	47-52
9184911-10	1997	Three IgM antibodies had hydrophilic arginine residues in their CDR3 heavy chain region.	Arginine	37-45	cerebellar degeneration-related 3	Mus musculus	64-68
17025265-1	2006	Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine.	Arginine	58-68	antizyme inhibitor 2	Homo sapiens	83-105
9173902-2	1997	In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2.	Arginine	91-94	aldo-keto reductase family 1 member C1	Homo sapiens	148-151
9173902-2	1997	In the present study we performed site-directed mutagenesis of the seven residues (Thr-38, Arg-47, Leu-54, Cys-87, Val-151, Arg-170 and Gln-172) of DD1 to the corresponding residues (Val, His, Val, Ser, Met, His and Leu respectively) of DD2.	Arginine	124-127	aldo-keto reductase family 1 member C1	Homo sapiens	148-151
16729975-4	2006	Replacement of sumoylation site lysines with arginine or overexpression of SENP1, a desumoylation enzyme, enhances the transactivation ability of Ets-1.	Arginine	45-53	ETS proto-oncogene 1, transcription factor	Homo sapiens	146-151
16713997-7	2006	Furthermore, l-arginine-induced NO formation was accompanied by a reduction in oxidative stress and an increase in protein expression and enzyme activity of heme oxygenase (HO)-1.	Arginine	13-23	heme oxygenase 1	Homo sapiens	157-178
9137904-1	1997	Administration of rat C-peptide (0.1 mumol/l) to isolated rat pancrease failed to inhibit insulin release induced by a high concentration of D-glucose (11.1 mmol/l) but prevented the progressive increase in insulin output otherwise observed during prolonged perfusion in the presence of 3.3 mmol/l glucose and 5.0 mmol/l L-arginine.	Arginine	321-331	insulin 2	Rattus norvegicus	22-31
16788192-5	2006	This increase in L-arginine uptake was independent of activation with gamma interferon plus lipopolysaccharide and correlated with increased expression of the MCAT1 and MCAT2 cationic amino acid transport genes.	Arginine	17-27	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	159-164
9097963-6	1997	Genetic analysis revealed the presence of an unusual heterozygous mutation in exon 11 of the RET proto-oncogene representing a duplication of 12 bp resulting in the insertion of four amino acids between codon 634 (Cys) and 635 (Arg), thus creating an additional cysteine residue.	Arginine	228-231	ret proto-oncogene	Homo sapiens	93-96
16380201-2	2006	The expression of the argininosuccinate synthetase gene (ASS), the limiting enzyme of arginine synthesis, was previously shown to be rapidly induced by a short-term (4 h) exposure to IL-1beta in Caco-2 cells [Biochimie, 2005, 403-409].	Arginine	86-94	argininosuccinate synthase 1	Homo sapiens	22-55
9085842-5	1997	Three proteins in the tri-snRNP complex with approximate molecular weights of 27, 60, and 100 kDa were phosphorylated by purified snRNP-associated protein kinase, which has been shown previously to phosphorylate the serine/ arginine-rich domains of U1-70K and SF2/ASF (Woppmann A et al., 1993, Nucleic Acids Res 21:2815-2822).	Arginine	224-232	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	26-31
9085842-5	1997	Three proteins in the tri-snRNP complex with approximate molecular weights of 27, 60, and 100 kDa were phosphorylated by purified snRNP-associated protein kinase, which has been shown previously to phosphorylate the serine/ arginine-rich domains of U1-70K and SF2/ASF (Woppmann A et al., 1993, Nucleic Acids Res 21:2815-2822).	Arginine	224-232	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	130-135
9085842-5	1997	Three proteins in the tri-snRNP complex with approximate molecular weights of 27, 60, and 100 kDa were phosphorylated by purified snRNP-associated protein kinase, which has been shown previously to phosphorylate the serine/ arginine-rich domains of U1-70K and SF2/ASF (Woppmann A et al., 1993, Nucleic Acids Res 21:2815-2822).	Arginine	224-232	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	249-255
16380201-2	2006	The expression of the argininosuccinate synthetase gene (ASS), the limiting enzyme of arginine synthesis, was previously shown to be rapidly induced by a short-term (4 h) exposure to IL-1beta in Caco-2 cells [Biochimie, 2005, 403-409].	Arginine	86-94	argininosuccinate synthase 1	Homo sapiens	57-60
9065444-7	1997	There is NMR spectral evidence suggesting that the Arg-Asp buttressing interaction observed in the Zif-268.DNA complex is also preserved in unbound Sp1f2 and Sp1f3.	Arginine	51-54	early growth response 1	Homo sapiens	99-106
16552718-4	2006	The Leu-enkephalin peptide-micelle association constant increased from 130 +/- 8 to 1459 +/- 57 and 1744 +/- 64 M(-1), respectively, when an Arg or Lys was added to the C-terminus.	Arginine	141-144	prodynorphin	Homo sapiens	4-18
9092626-9	1997	We propose that Lys-38, Glu-43, Arg-51 and Glu-52 residues in the conserved region are essential to exert 8-oxo-dGTPase activity.	Arginine	32-35	nudix hydrolase 1	Homo sapiens	106-119
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Arginine	82-90	Cbl proto-oncogene	Homo sapiens	142-145
16543241-5	2006	In this study, we have identified Lys377 of RIP as the functional ubiquitination site, because mutating this residue to arginine completely abolished RIP-mediated NF-kappaB activation.	Arginine	120-128	receptor interacting serine/threonine kinase 1	Homo sapiens	44-47
9132063-1	1997	The Arabidopsis G alpha subunit, GP alpha1, was expressed within Escherichia coli by co-transformation with the expression vector and the dnaY gene which encodes tRNA(Arg)(AGA/AGG) Isolation of the recombinant GP alpha1 in a highly pure form could be achieved by a combination of anion exchange and dye affinity chromatography or by a single step affinity procedure via chromatography on 4-amino-anilido-GTP agarose.	Arginine	167-170	G protein alpha subunit 1	Arabidopsis thaliana	4-42
9038155-2	1997	Since shortening the side chains of Trp-800, Arg-812, and Leu-813 in smooth muscle myosin light chain kinase abrogated calmodulin-dependent activation (Bagchi, I. C., Huang, Q., and Means, A. R. (1992) J. Biol.	Arginine	45-48	myosin light chain kinase	Homo sapiens	69-108
9038155-6	1997	Alanine substitutions at positions on the smooth muscle myosin light chain kinase peptide, corresponding to Trp-800 and Arg-812 in the enzyme, produced an 8-fold increase in the enzyme inhibition constant in contrast with the abolition of calmodulin binding by similar mutations in the parent enzyme.	Arginine	120-123	myosin light chain kinase	Homo sapiens	42-81
16543241-5	2006	In this study, we have identified Lys377 of RIP as the functional ubiquitination site, because mutating this residue to arginine completely abolished RIP-mediated NF-kappaB activation.	Arginine	120-128	receptor interacting serine/threonine kinase 1	Homo sapiens	150-153
16670618-5	2006	RESULTS: Serum amylase and lipase levels increased after L-arginine injection, maximal levels occurring at 3 and 12 hours postinjection, respectively.	Arginine	57-67	lipase G, endothelial type	Rattus norvegicus	27-33
16434405-1	2006	A mutation linked to autistic spectrum disorders encodes an Arg to Cys replacement in the C-terminal portion of the extracellular domain of neuroligin-3.	Arginine	60-63	neuroligin 3	Homo sapiens	140-152
9065690-7	1997	The UAS(arg), containing the previously defined "arginine boxes" is the region that responds to the inducer through the action of the ArgRp-Mcm1p proteins, and its deletion alone significantly affects growth on arginine as sole nitrogen source.	Arginine	8-11	transcription factor MCM1	Saccharomyces cerevisiae S288C	140-145
9065690-7	1997	The UAS(arg), containing the previously defined "arginine boxes" is the region that responds to the inducer through the action of the ArgRp-Mcm1p proteins, and its deletion alone significantly affects growth on arginine as sole nitrogen source.	Arginine	49-57	transcription factor MCM1	Saccharomyces cerevisiae S288C	140-145
9065690-7	1997	The UAS(arg), containing the previously defined "arginine boxes" is the region that responds to the inducer through the action of the ArgRp-Mcm1p proteins, and its deletion alone significantly affects growth on arginine as sole nitrogen source.	Arginine	211-219	transcription factor MCM1	Saccharomyces cerevisiae S288C	140-145
9065690-8	1997	The functional UAS(arg) is about 60 nucleotides long, and contains two sequences homologous to the binding site for MADS-box proteins, to which ArgRIp and Mcm1p belong.	Arginine	19-22	transcription factor MCM1	Saccharomyces cerevisiae S288C	155-160
9065690-10	1997	Interestingly, we have found that induction of CAR1 expression by arginine in the presence of an optimal nitrogen source is counteracted by Gln3p, independently of its action at the GATAA sequences.	Arginine	66-74	arginase	Saccharomyces cerevisiae S288C	47-51
16434405-5	2006	Although these proteins have distinct oligomeric assemblies and cellular dispositions, homologous Arg residues in neuroligin-3 (Arg-451), in butyrylcholinesterase (Arg-386), and in acetylcholinesterase (Arg-395) are conserved in all studied mammalian species.	Arginine	98-101	neuroligin 3	Homo sapiens	114-126
9065690-10	1997	Interestingly, we have found that induction of CAR1 expression by arginine in the presence of an optimal nitrogen source is counteracted by Gln3p, independently of its action at the GATAA sequences.	Arginine	66-74	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	140-145
16434405-5	2006	Although these proteins have distinct oligomeric assemblies and cellular dispositions, homologous Arg residues in neuroligin-3 (Arg-451), in butyrylcholinesterase (Arg-386), and in acetylcholinesterase (Arg-395) are conserved in all studied mammalian species.	Arginine	128-131	neuroligin 3	Homo sapiens	114-126
16434405-5	2006	Although these proteins have distinct oligomeric assemblies and cellular dispositions, homologous Arg residues in neuroligin-3 (Arg-451), in butyrylcholinesterase (Arg-386), and in acetylcholinesterase (Arg-395) are conserved in all studied mammalian species.	Arginine	128-131	neuroligin 3	Homo sapiens	114-126
16434405-5	2006	Although these proteins have distinct oligomeric assemblies and cellular dispositions, homologous Arg residues in neuroligin-3 (Arg-451), in butyrylcholinesterase (Arg-386), and in acetylcholinesterase (Arg-395) are conserved in all studied mammalian species.	Arginine	128-131	neuroligin 3	Homo sapiens	114-126
16257923-7	2006	iNOS was significantly increased by arginine but not by glutamine following gut I/R and was associated with increased MPO activity and mucosal injury.	Arginine	36-44	myeloperoxidase	Rattus norvegicus	118-121
9020120-0	1997	Molecular determinants of arg-gly-asp ligand specificity for beta3 integrins.	Arginine	26-29	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	61-66
9020120-10	1997	These results confirm that subtle changes in the amino acid composition immediately flanking the RGD or RYD motifs can have a profound effect on beta3 integrin specificity, most likely because they influence the juxtaposition of the arginine and aspartate side chains within the extended RGD loop sequence.	Arginine	233-241	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	145-150
16497569-10	2006	Therefore, the modification of Arg-410 via oxidative stress may promote the elimination of HSA.	Arginine	31-34	CD24a antigen	Mus musculus	91-94
9052446-5	1997	RESULTS: Tumours from patients receiving L-arginine contained increased numbers of specific cell subsets within the tumour which expressed CD16 (P = 0.004) and CD56 (P = 0.001) surface markers, when compared with tumours from control patients.	Arginine	41-51	neural cell adhesion molecule 1	Homo sapiens	160-164
16493708-4	2006	It was identified, following trypsin digestion, by MS peptide analysis as the complement component, complement 4a (C4a) des Arg.	Arginine	124-127	complement C4A (Rodgers blood group)	Homo sapiens	115-118
9048335-4	1997	Polystyrene beads coated with Arg-Gly-Asp (RGD)-containing peptide adhere to the surface of sublethally injured MPT cells but not to control, dextrose-treated cells, indicating that the beta 1 integrins present on the apical surface of the cell remain functional.	Arginine	30-33	hemoglobin, beta adult major chain	Mus musculus	186-192
16493708-5	2006	Plasma levels of C4a des Arg measured by ELISA confirmed that the levels were significantly higher (p &lt; 0.0001) in IPAH patients (2.12 +/- 0.27 microg/mL) compared with normal controls (0.53 +/- 0.05 microg/mL).	Arginine	25-28	complement C4A (Rodgers blood group)	Homo sapiens	17-20
16513844-3	2006	Here, we show that the heterogenous ribonucleoprotein A18 (hnRNP A18) RNA Binding Domain (RBD) and the arginine, glycine (RGG) rich domain can bind TRX 3"-untranslated region (3"-UTR) independently but both domains are required for maximal binding.	Arginine	103-111	thioredoxin	Homo sapiens	148-151
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Arginine	151-154	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	102-120
9110362-1	1997	Single nucleotide substitutions are known to result in a different amino acid at one of four sites in cytochrome P4502C9 (CYP2C9) namely: residue 144: Arg/Cys; residue 358: Tyr/Cys; residue 359: Ile/Leu and residue 417: Gly/Asp.	Arginine	151-154	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	122-128
16405520-7	2006	RESULTS: In vitro adhesion assays revealed that VWF is able to promote a dose-dependent adhesion of B16-BL6 cells via its Arg-Gly-Asp (RGD) sequence.	Arginine	122-125	Von Willebrand factor	Mus musculus	48-51
9495318-8	1997	When this nonconserved arginine residue was changed to alanine the CRP1 NLS behaved as a classical bipartite signal, suggesting that bipartite NLSs are present in all family members but that NLSs of the individual members differ slightly.	Arginine	23-31	CCAAT enhancer binding protein epsilon	Homo sapiens	67-71
8990085-4	1997	In addition, arginines at any of five positions in CDR1, CDR2, or FWR3 of the heavy chain contribute contacts with the antigen.	Arginine	13-22	cerebellar degeneration related protein 1	Homo sapiens	51-55
9606729-1	1997	NMR spectroscopy has been used to obtain structural information on the bioactive conformation of the nonapeptide hormone bradykinin (Arg-Pro-Pro-Gly-Ser-Pro-Phe-Arg, BK) bound to the Fab-fragment of an antibody that mimics the hormone binding site of the natural bradykinin B2-receptor.	Arginine	133-136	FA complementation group B	Homo sapiens	183-186
16500893-0	2006	RNA-binding of the human cytomegalovirus transactivator protein UL69, mediated by arginine-rich motifs, is not required for nuclear export of unspliced RNA.	Arginine	82-90	multifunctional expression regulator	Human betaherpesvirus 5	64-68
9066048-7	1997	From these findings, it appears that the Toxoplasma growth-inhibitory activity induced by lactoferrin in macrophages may be mediated by an L-arginine-dependent effector pathway that does not involve NO production.	Arginine	139-149	lactotransferrin	Bos taurus	90-101
8954792-5	1996	Type II arginase may be an important part of the arginine regulatory system affecting nitric oxide synthase, arginine decarboxylase, kyotorphin synthase, and arginine-glycine transaminase activities and polyamine and proline biosynthesis.	Arginine	49-57	antizyme inhibitor 2	Homo sapiens	109-131
8968849-1	1996	OBJECTIVE: The Trp64--&gt;Arg allele of the beta 3-adrenergic receptor gene was recently proposed to be associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), features of insulin resistance and a tendency to gain weight.	Arginine	26-29	adrenoceptor beta 3	Homo sapiens	44-70
9010772-2	1996	We earlier reported the co-localization of arginine-specific ADP-ribosyltransferase [EC 2.4.2.31] and its target protein p33 (mim-1 protein) in cytoplasmic granules in chicken polymorphonuclear leukocytes (so-called heterophils) [Mishima, K., Terashima, M., Obara, S., Yamada, K., Imai, K., and Shimoyama, M. (1991) J. Biochem.	Arginine	43-51	leukocyte cell derived chemotaxin 2	Gallus gallus	121-124
9010772-2	1996	We earlier reported the co-localization of arginine-specific ADP-ribosyltransferase [EC 2.4.2.31] and its target protein p33 (mim-1 protein) in cytoplasmic granules in chicken polymorphonuclear leukocytes (so-called heterophils) [Mishima, K., Terashima, M., Obara, S., Yamada, K., Imai, K., and Shimoyama, M. (1991) J. Biochem.	Arginine	43-51	leukocyte cell derived chemotaxin 2	Gallus gallus	126-131
8981210-0	1996	L-arginine prevents heart transplant arteriosclerosis by modulating the vascular cell proliferative response to insulin-like growth factor-I and interleukin-6.	Arginine	0-10	insulin-like growth factor I	Oryctolagus cuniculus	112-140
8981210-8	1996	The L-arginine significantly inhibits graft vascular cell proliferation induced by (1) insulin-like growth factor-I, from 328% +/- 66% to 154% +/- 28% (p &lt; 0.05), (2) interleukin-6, from 376% +/- 97% to 138% +/- 30% (p &lt; 0.05) and (3) the combination of insulin-like growth factor-I and interleukin-6 from 710% +/- 201% to 226% +/- 72% (p &lt; 0.05).	Arginine	4-14	insulin-like growth factor I	Oryctolagus cuniculus	87-115
8981210-8	1996	The L-arginine significantly inhibits graft vascular cell proliferation induced by (1) insulin-like growth factor-I, from 328% +/- 66% to 154% +/- 28% (p &lt; 0.05), (2) interleukin-6, from 376% +/- 97% to 138% +/- 30% (p &lt; 0.05) and (3) the combination of insulin-like growth factor-I and interleukin-6 from 710% +/- 201% to 226% +/- 72% (p &lt; 0.05).	Arginine	4-14	insulin-like growth factor I	Oryctolagus cuniculus	260-288
8981210-9	1996	In recipient native aorta explants L-arginine also abolishes vascular cell proliferation stimulated by insulin-like growth factor-I and interleukin-6.	Arginine	35-45	insulin-like growth factor I	Oryctolagus cuniculus	103-131
9000287-4	1996	However, following initial transient increases in PAP and PVR in the ARGININE group, subsequent pulmonary vasodilation gradually reduced PVR, and thus PAP, in spite of the ongoing elevation of BF through the left lung.	Arginine	69-77	PVR cell adhesion molecule	Homo sapiens	137-140
8894181-12	1996	The results obtained indicate that the attenuation of the LCL response by L- and D-enantiomers of arginine analogues, is a non-specific effect as there was no inhibition of NADPH-oxidase and MPO activity, MPO release or oxygen consumption.	Arginine	98-106	myeloperoxidase	Rattus norvegicus	205-208
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Arginine	32-40	eukaryotic translation initiation factor 4B	Homo sapiens	80-111
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Arginine	32-40	eukaryotic translation initiation factor 4B	Homo sapiens	113-118
8816444-6	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine, termed the DRYG domain, is sufficient for self-association of eIF4B, both in vitro and in vivo, and for interaction with the p170 subunit of eIF3.	Arginine	32-40	eukaryotic translation initiation factor 4B	Homo sapiens	127-132
8816450-4	1996	In this study, we examined the functional role of cysteine and arginine residues in the ligand-binding domain of hRAR alpha (hRAR alpha-LBD, amino acids 154 to 462).	Arginine	63-71	retinoic acid receptor alpha	Homo sapiens	113-139
8816501-1	1996	CAR1 (arginase) gene expression responds to multiple environmental signals; expression is induced in response to the intracellular accumulation of arginine and repressed when readily transported and catabolized nitrogen sources are available in the environment.	Arginine	147-155	arginase	Saccharomyces cerevisiae S288C	0-4
8816501-7	1996	A single URS1 site mediates repression of CAR1 arginine-independent upstream activator site (UAS) activity in the absence of arginine and the presence of a poor nitrogen source (a condition under which the inducer-independent Gln3p can function in association with the UASNTR sites).	Arginine	47-55	arginase	Saccharomyces cerevisiae S288C	42-46
8816501-7	1996	A single URS1 site mediates repression of CAR1 arginine-independent upstream activator site (UAS) activity in the absence of arginine and the presence of a poor nitrogen source (a condition under which the inducer-independent Gln3p can function in association with the UASNTR sites).	Arginine	47-55	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	226-231
8798644-9	1996	Protein modeling of rabbit proacrosin using chymotrypsinogen A as a three-dimensional model indicated that an exposed loop Asp35 to His40 in chymotrypsinogen A is extended with an additional five amino acid residues in rabbit proacrosin from Ile43 to His53 containing arginine residues Arg47, Arg50 and Arg51.	Arginine	268-276	acrosin	Homo sapiens	27-37
8798644-9	1996	Protein modeling of rabbit proacrosin using chymotrypsinogen A as a three-dimensional model indicated that an exposed loop Asp35 to His40 in chymotrypsinogen A is extended with an additional five amino acid residues in rabbit proacrosin from Ile43 to His53 containing arginine residues Arg47, Arg50 and Arg51.	Arginine	268-276	acrosin	Homo sapiens	226-236
8798644-11	1996	These results are consistent with the hypothesis that rabbit proacrosin contains a specific zona pellucida binding site and that the loop containing arginine residues 50 and 51 is critical for zona binding activity.	Arginine	149-157	acrosin	Homo sapiens	61-71
8781232-2	1996	U2AF65 contains an RNA binding domain, required for interaction with the polypyrimidine tract, and an arginine-serine-rich (RS) region, required for U2 snRNP recruitment and splicing.	Arginine	102-110	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	0-6
16293446-4	2006	We show that the mitochondrial form of Ogg1 is functionally active at processing 8-oxo-dGuo lesions and that Ogg1-deficient cells exhibit nearly six-fold elevated rate of Arg+ mutants under normal growth condition, as compared to the parent.	Arginine	171-174	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	39-43
16293446-4	2006	We show that the mitochondrial form of Ogg1 is functionally active at processing 8-oxo-dGuo lesions and that Ogg1-deficient cells exhibit nearly six-fold elevated rate of Arg+ mutants under normal growth condition, as compared to the parent.	Arginine	171-174	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	109-113
16293446-5	2006	Overexpression of Ogg1 completely suppressed the high rate of Arg+ mutations to levels lower than the parental, suggesting that Ogg1 function could be limited in the mitochondria.	Arginine	62-65	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	18-22
16293446-8	2006	We also demonstrate that overproduction of the major apurinic/apyrimidinic (AP) endonuclease Apn1, a nuclear and mitochondrial enzyme with multiple DNA repair activities, substantially elevated the rate of Arg+ mutants, but which was counteracted by Ogg1 overexpression.	Arginine	206-209	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	93-97
16779912-0	2006	L-arginine supplementation causes additional effects on exercise-induced angiogenesis and VEGF expression in the heart and hind-leg muscles of middle-aged rats.	Arginine	0-10	vascular endothelial growth factor A	Rattus norvegicus	90-94
16779912-7	2006	A Western blot analysis showed that training with L-arginine significantly increased VEGF protein expression by 2.9-fold in the soleus muscle and by 1.7-fold in the left ventricle, but the increase with training alone was insignificant.	Arginine	50-60	vascular endothelial growth factor A	Rattus norvegicus	85-89
16779912-10	2006	The present results suggest that in middle-aged rats, L-arginine administration caused additional effects on exercise-induced angiogenesis by presumably promoting VEGF expression in the hind-leg muscle as well as in the left ventricle.	Arginine	54-64	vascular endothelial growth factor A	Rattus norvegicus	163-167
16418283-4	2006	These results suggest that TM functions by alleviating the Ca(2+)-dependent inhibitory interactions of Arg-67 of protein C and Arg-35 of thrombin.	Arginine	103-106	thrombomodulin	Homo sapiens	27-29
16418283-4	2006	These results suggest that TM functions by alleviating the Ca(2+)-dependent inhibitory interactions of Arg-67 of protein C and Arg-35 of thrombin.	Arginine	127-130	thrombomodulin	Homo sapiens	27-29
16841884-0	2006	L-arginine decreases heat shock protein 70 (marker of environmental stress) expression in kidney cells of rat fetuses during apoptosis--Late effect of Adriamycin action.	Arginine	0-10	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	21-42
16168628-0	2006	Identification of a pre-mRNA splicing factor, arginine/serine-rich 3 (Sfrs3), and its co-expression with fibronectin in fetal and postnatal rabbit airway mucosal and skin wounds.	Arginine	46-54	serine/arginine-rich splicing factor 3	Oryctolagus cuniculus	70-75
16441918-0	2006	L-Arginine attenuates xanthine oxidase and myeloperoxidase activities in hearts of rats during exhaustive exercise.	Arginine	0-10	myeloperoxidase	Rattus norvegicus	43-58
8805642-0	1996	Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies.	Arginine	47-55	cerebellar degeneration-related 3	Mus musculus	62-66
8805642-4	1996	The VH structures of most autoimmune anti-DNA Abs include at least one arginine in VH-CDR3; moreover, previous results led us to propose that anti-DNA Ab specificity for dsDNA may be dependent upon the relative position of arginines in VH-CDR3.	Arginine	71-79	cerebellar degeneration-related 3	Mus musculus	86-90
16344367-1	2006	Endothelial NO synthase (eNOS) produces superoxide when depleted of (6R)-5,6,7,8-tetrahydro-L-biopterin (BH4) and L-arginine by uncoupling the electron flow from NO production.	Arginine	114-124	nitric oxide synthase 3, endothelial cell	Mus musculus	25-29
8805642-4	1996	The VH structures of most autoimmune anti-DNA Abs include at least one arginine in VH-CDR3; moreover, previous results led us to propose that anti-DNA Ab specificity for dsDNA may be dependent upon the relative position of arginines in VH-CDR3.	Arginine	223-232	cerebellar degeneration-related 3	Mus musculus	86-90
8805642-5	1996	The present results demonstrate a strong correlation between specificity for dsDNA and arginine position in VH-CDR3, for Abs with V, encoded by VH genes from the VH7183, VHQ52, and VHS107 families but not from the VH558 family.	Arginine	87-95	cerebellar degeneration-related 3	Mus musculus	111-115
8805642-6	1996	Specificity for dsDNA was not only correlated to the presence of VH-CDR3 arginines but also to the relative position of the arginines in VH-CDR3.	Arginine	73-82	cerebellar degeneration-related 3	Mus musculus	68-72
17071716-4	2006	Notably, we observe pronounced tilting of the axis of dsDNA with respect to the PCNA ring plane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine and lysine residues lining the PCNA inner surface.	Arginine	183-191	proliferating cell nuclear antigen	Homo sapiens	80-84
17071716-4	2006	Notably, we observe pronounced tilting of the axis of dsDNA with respect to the PCNA ring plane reflecting interactions between the DNA phosphodiester backbone and positively charged arginine and lysine residues lining the PCNA inner surface.	Arginine	183-191	proliferating cell nuclear antigen	Homo sapiens	223-227
8790354-7	1996	A second site, containing Arg-103 and Ser-104 (and possibly Arg-14), is involved in binding a second EPO-R at the cell surface, thus forming a homodimeric receptor complex.	Arginine	26-29	erythropoietin receptor	Homo sapiens	101-106
8790354-7	1996	A second site, containing Arg-103 and Ser-104 (and possibly Arg-14), is involved in binding a second EPO-R at the cell surface, thus forming a homodimeric receptor complex.	Arginine	60-63	erythropoietin receptor	Homo sapiens	101-106
16267042-7	2005	Phosphopeptide mapping experiments revealed that the Lys-163 --&gt; Arg mutation also interferes with proper in vivo but not in vitro phosphorylation of cytokine-responsive serine residues located in the distal C-terminal region of IKKbeta.	Arginine	68-71	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	232-239
8913654-4	1996	RESULTS: Human TAP preferentially translocated analogues with residues leucine, isoleucine, methionine and arginine as the carboxy-terminal amino acids, whereas analogues with aspartic acid and serine were translocated poorly.	Arginine	107-115	filamin B	Homo sapiens	15-18
16186124-6	2005	Of the 15 PAHX residues observed to be mutated in RD patients, 11 cluster in two distinct groups around the Fe(II) (Pro(173), His(175), Gln(176), Asp(177), and His(220)) and 2OG binding sites (Trp(193), Glu(197), Ile(199), Gly(204), Asn(269), and Arg(275)).	Arginine	247-250	phytanoyl-CoA 2-hydroxylase	Homo sapiens	10-14
8702765-1	1996	The Arg-Gly-Asp (RGD) sequence within the third complementarity-determining region (CDR3) of the heavy chain (H3) is responsible for the binding of the recombinant murine Fab molecules, AP7 and PAC1.1, to the platelet integrin alphaIIbbeta3.	Arginine	4-7	cerebellar degeneration-related 3	Mus musculus	84-88
8702765-1	1996	The Arg-Gly-Asp (RGD) sequence within the third complementarity-determining region (CDR3) of the heavy chain (H3) is responsible for the binding of the recombinant murine Fab molecules, AP7 and PAC1.1, to the platelet integrin alphaIIbbeta3.	Arginine	4-7	dual specificity phosphatase 2	Mus musculus	194-198
8702827-0	1996	Arginine 75 in the pseudosubstrate sequence of type Ibeta cGMP-dependent protein kinase is critical for autoinhibition, although autophosphorylated serine 63 is outside this sequence.	Arginine	0-8	protein kinase cGMP-dependent 1	Homo sapiens	58-87
16294045-0	2005	The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.	Arginine	26-34	tumor protein p53 binding protein 1	Homo sapiens	17-22
16294045-3	2005	Herein, we show that the GAR motif of 53BP1 is arginine methylated by protein arginine methyltransferase 1 (PRMT1), the same methyltransferase that methylates MRE11.	Arginine	47-55	tumor protein p53 binding protein 1	Homo sapiens	38-43
16294045-5	2005	Amino acid substitution of the arginines within the GAR motif of 53BP1 abrogated binding to single and double-stranded DNA, demonstrating that the GAR motif is required for DNA binding activity of 53BP1.	Arginine	31-40	tumor protein p53 binding protein 1	Homo sapiens	65-70
16294045-5	2005	Amino acid substitution of the arginines within the GAR motif of 53BP1 abrogated binding to single and double-stranded DNA, demonstrating that the GAR motif is required for DNA binding activity of 53BP1.	Arginine	31-40	tumor protein p53 binding protein 1	Homo sapiens	197-202
8807893-1	1996	Solution structures of RNA aptamers for FMN, ATP, arginine, and citrulline reveal how oligonucleotides can fold to form selective binding pockets for biological cofactors and amino acids.	Arginine	50-58	formin 1	Homo sapiens	40-43
16294047-4	2005	Here we show that a glycine-arginine rich (GAR) stretch of 53BP1 lying upstream of the Tudor motifs is methylated.	Arginine	28-36	tumor protein p53 binding protein 1	Homo sapiens	59-64
16284309-7	2005	Mutational analysis of p33 revealed that its intracellular sorting is also mediated by several targeting signals, including three peroxisomal targeting elements that function cooperatively, plus a pER targeting signal resembling an Arg-based motif responsible for vesicle-mediated retrieval of escaped ER membrane proteins from the Golgi.	Arginine	232-235	inhibitor of growth family member 1	Homo sapiens	23-26
8864793-3	1996	We tested the hypothesis that intravenous administration of L-arginine (L-ARG), the physiological precursor of EDRF/NO, stimulates the production of NO, subsequently increasing plasma cGMP levels and reducing systemic and/or pulmonary blood pressure, in patients with coronary artery disease (CAD, n = 16) or with primary pulmonary hypertension (PPH, n = 5).	Arginine	60-70	alpha hemoglobin stabilizing protein	Homo sapiens	111-115
8864793-3	1996	We tested the hypothesis that intravenous administration of L-arginine (L-ARG), the physiological precursor of EDRF/NO, stimulates the production of NO, subsequently increasing plasma cGMP levels and reducing systemic and/or pulmonary blood pressure, in patients with coronary artery disease (CAD, n = 16) or with primary pulmonary hypertension (PPH, n = 5).	Arginine	72-77	alpha hemoglobin stabilizing protein	Homo sapiens	111-115
8863155-1	1996	In five different Japanese families, we identified six male hemizygotes (aged 6, 9, 15, 17, 56, and 65 years) and a putative candidate (aged 48 years), carrying a mutant allele of the ornithine transcarbamylase (OTC) gene, a G to A substitution at nucleotide 119 in exon 2 generating histidine in place of arginine.	Arginine	306-314	ornithine transcarbamylase	Homo sapiens	212-215
8666140-9	1996	Single-strand conformational analysis and nucleotide sequencing of the entire coding region of the PC3 gene in 102 Japanese subjects with NIDDM revealed missense mutations in exons 2 (Arg/Gln53) and 14 (Gln/Glu638), neither of which was associated with NIDDM in this population.	Arginine	184-187	proprotein convertase subtilisin/kexin type 1	Homo sapiens	99-102
8774538-4	1996	Like many members of the integrin family, alpha v beta 3 recognizes the sequence Arg-Gly-Asp (RGD) in its ligands, and other molecules that contain this sequence will complete with the natural ligands (such as vitronectin) for binding.	Arginine	81-84	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	50-56
8663146-4	1996	A glutathione S-transferase (GST) fusion of the putative methyltransferase modifies arginine residues, in appropriate protein substrates, to form NG-monomethyl and NG,NG-dimethylarginine (asymmetric).	Arginine	84-92	glutathione S-transferase kappa 1	Homo sapiens	2-27
8663146-4	1996	A glutathione S-transferase (GST) fusion of the putative methyltransferase modifies arginine residues, in appropriate protein substrates, to form NG-monomethyl and NG,NG-dimethylarginine (asymmetric).	Arginine	84-92	glutathione S-transferase kappa 1	Homo sapiens	29-32
8654975-2	1996	The originally characterized Rm-resistant (RmR) TOR1-1 and TOR2-1 alleles contain an Arg in place of a conserved Ser residue, which lies adjacent to the phosphatidylinositol (PI) kinase-related domain of TOR (Ser1972 in TOR1; Ser1975 in TOR2).	Arginine	85-88	phosphatidylinositol kinase-related protein kinase TOR2	Saccharomyces cerevisiae S288C	59-63
8670298-2	1996	Human NP220 (hNP220) has an arginine/serine-rich motif found in non-small nuclear RNP splicing factors (SR proteins) and shares three domains (MH1, MH2 and MH3) with an acidic nuclear matrix protein, matrin 3.	Arginine	28-36	zinc finger protein 638	Homo sapiens	6-11
8670298-2	1996	Human NP220 (hNP220) has an arginine/serine-rich motif found in non-small nuclear RNP splicing factors (SR proteins) and shares three domains (MH1, MH2 and MH3) with an acidic nuclear matrix protein, matrin 3.	Arginine	28-36	zinc finger protein 638	Homo sapiens	13-19
8662780-0	1996	Contribution of arginine residues in the RP135 peptide derived from the V3 loop of gp120 to its interaction with the Fv fragment of the 0.5beta HIV-1 neutralizing antibody.	Arginine	16-24	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	83-88
8764214-2	1996	Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it.	Arginine	162-165	bradykinin receptor B2	Homo sapiens	205-216
8764214-2	1996	Bradykinin induced a significant increase in [3H]glycoconjugate secretion in a dose-dependent manner from isolated glands, which was significantly inhibited by D-Arg-(Hyp3, Thi5,8, D-Phe7)-bradykinin (the B2-receptor antagonist), whereas Des-Arg9-(Leu8)-bradykinin (B1-receptor antagonist) or indomethacin did not significantly alter it.	Arginine	162-165	selectin L	Homo sapiens	248-252
16844013-8	1996	When TPN was administered for 2 weeks, the rate of BT decreased significantly (P &lt; 0.05) and IL-2 production increased markedly (P &lt; 0.01) in the TPN-ARG group compared with those in the TPN group.	Arginine	156-159	interleukin 2	Rattus norvegicus	96-100
16844013-9	1996	Our results suggest that arginine can decrease BT and increase IL-2 production in rats during prolonged TPN.	Arginine	25-33	interleukin 2	Rattus norvegicus	63-67
8799825-7	1996	Cell-binding fibronectin fragments (type III repeats 6-10) containing the Arg-Gly-Asp (RGD) sequence blocked both nodule initiation and maturation, whether or not they contained a functional synergy site.	Arginine	74-77	fibronectin 1	Rattus norvegicus	13-24
8783101-6	1996	The DNA sequence of the PCR products from clinically established MEN 2A patients showed a mutation at codon 634 (TGC--&gt;CGC) that resulted in an amino acid change from cysteine to arginine.	Arginine	182-190	ret proto-oncogene	Homo sapiens	65-71
8854644-16	1996	CONCLUSION: L-arginine: NO pathway can be activated in malignant ascites by IL-2 therapy and NO synthesis functions as an inhibitory mechanism against IL-2 induced anti-tumor effects.	Arginine	12-22	interleukin 2	Mus musculus	76-80
8854644-16	1996	CONCLUSION: L-arginine: NO pathway can be activated in malignant ascites by IL-2 therapy and NO synthesis functions as an inhibitory mechanism against IL-2 induced anti-tumor effects.	Arginine	12-22	interleukin 2	Mus musculus	151-155
8658052-9	1996	Because in the antigen-stimulated acute infection spleen or granuloma cultures the co-stimulatory effect by FN was abrogated by the tripeptide (RGD) arg-gly asp, and anti alpha 5 beta 1 antibody, enhancement is attributed to signalling via the alpha 5 beta 1 integrin receptor of lymphocytes.	Arginine	149-152	fibronectin 1	Mus musculus	108-110
8662674-10	1996	Thus, NO production by cardiac myocytes exposed to IL-1beta plus IFNgamma appears to be dependent on the coinduction of CAT-1, CAT-2A, and CAT-2B, while insulin independently augments L-arginine transport through CAT- 1.	Arginine	184-194	interferon gamma	Rattus norvegicus	65-73
8649853-3	1996	Using a C-terminal segment of Arg we identified a novel protein, ArgBP1 (Arg binding protein 1).	Arginine	30-33	abl interactor 2	Homo sapiens	65-71
8649853-3	1996	Using a C-terminal segment of Arg we identified a novel protein, ArgBP1 (Arg binding protein 1).	Arginine	30-33	abl interactor 2	Homo sapiens	73-94
8612536-8	1996	Furthermore, L-Arg (1 or 10.0 mM) and the NO donor, sodium nitroprusside (1 or 10.0 mM), stimulated the basal and K(+)-induced in vitro release of LHRH and NPY from the hypothalami of ovarian steroid-primed ovx rats.	Arginine	13-18	neuropeptide Y	Homo sapiens	156-159
8612536-13	1996	Additionally, the L-Arg-dependent potentiation of the LH surge may involve increased signaling in the NO and NPYergic systems, resulting in optimal LHRH hypersecretion from the hypothalamus.	Arginine	18-23	gonadotropin releasing hormone 1	Rattus norvegicus	148-152
8621635-6	1996	Although the determinants of the polyamine enhancement of iodo-MK-801 binding also localize to the NH2 terminus of NR2B, the point mutants at Arg-337 form receptors that are polyamine-stimulated at wild type levels.	Arginine	142-145	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	115-119
8934924-9	1996	Many of the RF-reactive sites on C gamma 2 and C gamma 3 as well as on beta 2m show common immunodominant valines, leucines, tryptophanes, arginines, lysines, and glutamines, thus comprising common reactive residues.	Arginine	139-148	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	33-56
8934924-9	1996	Many of the RF-reactive sites on C gamma 2 and C gamma 3 as well as on beta 2m show common immunodominant valines, leucines, tryptophanes, arginines, lysines, and glutamines, thus comprising common reactive residues.	Arginine	139-148	beta-2-microglobulin	Homo sapiens	71-78
8829454-0	1996	[CCl4 as an inducer of L-arginine-dependent NO synthesis].	Arginine	23-33	C-C motif chemokine ligand 4	Homo sapiens	1-5
16275762-3	2005	This peptide binds well to two human histocompatibility leukocyte antigen (HLA) allotypes, HLA-B*3501 and HLA-B*3508, which differ by a single amino acid at position 156 ((156)Leucine vs. (156)Arginine, respectively).	Arginine	193-201	major histocompatibility complex, class I, B	Homo sapiens	91-96
8631807-5	1996	Purified recombinant Rt6-2, but not Rt6-1, shows NAD+ glycohydrolase activity, which is inhibited by the arginine analogue agmatine.	Arginine	105-113	ADP-ribosyltransferase 2b	Mus musculus	21-26
8599236-15	1996	Likewise, chemical modification of the arginine residues of apo H had no effect on binding.	Arginine	39-47	apolipoprotein H	Homo sapiens	60-65
16275762-3	2005	This peptide binds well to two human histocompatibility leukocyte antigen (HLA) allotypes, HLA-B*3501 and HLA-B*3508, which differ by a single amino acid at position 156 ((156)Leucine vs. (156)Arginine, respectively).	Arginine	193-201	major histocompatibility complex, class I, B	Homo sapiens	106-111
16214096-2	2005	One of these modifications, citrullination, is the result of arginine deimination operated by an enzyme, peptidylarginine deiminase (PAD), whose activity is under strict genetic control.	Arginine	61-69	peptidyl arginine deiminase 4	Homo sapiens	105-131
8636973-1	1996	The structures of two ternary complexes of wheat serine carboxypeptidase II (CPD-WII), with a tetrapeptide aldehyde and a reaction product arginine, have been determined by X-ray crystallography at room temperature and -170 degrees.	Arginine	139-147	serine carboxypeptidase 2	Triticum aestivum	49-75
8576237-2	1996	Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase (NOS), and citrulline which is generated can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL).	Arginine	132-140	argininosuccinate lyase	Rattus norvegicus	182-205
8935176-4	1996	The data show that it is possible for a beta turn to exist in the ring portion of this molecule which contains the melanocortin conserved sequence - His-Phe-Arg-Trp-, even though the lowest energy conformers lack a beta turn.	Arginine	157-160	amyloid beta (A4) precursor protein	Mus musculus	38-44
8632754-6	1996	We concluded that the rat aorta tissue has a PAR-2 receptor that can be activated by peptides as short as four amino acids; the leucine and arginine at positions 2 and 5, respectively, of the proteolytically revealed PAR-2 receptor-activating sequence play key roles in regulating receptor function.	Arginine	140-148	F2R like trypsin receptor 1	Rattus norvegicus	45-50
8632754-6	1996	We concluded that the rat aorta tissue has a PAR-2 receptor that can be activated by peptides as short as four amino acids; the leucine and arginine at positions 2 and 5, respectively, of the proteolytically revealed PAR-2 receptor-activating sequence play key roles in regulating receptor function.	Arginine	140-148	F2R like trypsin receptor 1	Rattus norvegicus	217-222
8538347-6	1996	FINDINGS: The mutation in exon 5 of the 11 beta-HSD2 gene resulted in a premature stop site at codon 374 instead of a normal arginine (R374X), with the deletion of 32 aminoacids from the C-terminus of the 11 beta-HSD2 enzyme protein.	Arginine	125-133	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	40-52
8807337-2	1996	A mutation within the keratin type I (K14) gene (Met-->272-->Arg) in one family suffering from the generalized simplex (Koebner) form of the disease has been previously described (Humphries et al., Hum Mutat 2:37-42, 1993).	Arginine	61-64	keratin 14	Homo sapiens	22-41
8867769-3	1996	The patient had a C to T transition at the first position of codon 125, which resulted in Arg--&gt;Cys at the N-terminus of the rod domain in the keratin K14 gene.	Arginine	90-93	keratin 14	Homo sapiens	154-157
8719803-9	1995	Furthermore, activation of cells with LPS and IFN-gamma had no effect on uptake of the neutral amino acid L-citrulline but selectively increased the Vmax for L-arginine transport 2.8 fold and nitrite levels from 24 +/- 7 to 188 +/- 14 pmol micrograms-1 protein 24 h-1.	Arginine	158-168	interferon gamma	Rattus norvegicus	46-55
8719803-13	1995	Cycloheximide (1 microM) abolished induction of L-arginine transport and nitrite accumulation in response to LPS and IFN-gamma.	Arginine	48-58	interferon gamma	Rattus norvegicus	117-126
8770789-13	1995	GRP also caused moderate rise in plasma insulin and glucagon levels which were significantly reduced by L-NNA and this was partially restored by L-Arg.	Arginine	145-150	gastrin releasing peptide	Canis lupus familiaris	0-3
8636003-6	1995	Only one (1 of 12) tumor with high grade histology revealed a CGC-to-CTC (Arg to Leu) transversion in codon 246 of the p53 gene by the use of single strand conformation polymorphism (SSCP) analysis and direct sequencing.	Arginine	74-77	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	119-122
8526612-9	1995	The incidence of ventricular fibrillation, malonaldehyde release, and soluble intracellular adhesion molecule-1, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 were each significantly decreased during reperfusion in the L-arginine group.	Arginine	254-264	vascular cell adhesion molecule 1	Sus scrofa	160-193
7559657-10	1995	Substitutions of Tyr-405 by Phe (Y405F) and Arg-479 (R479T) by Thr completely inactivate the glutamate transporter.	Arginine	44-47	solute carrier family 17 (vesicular glutamate transporter), member 7 L homeolog	Xenopus laevis	93-114
7548140-8	1995	We conclude that upregulation of arginine transport is part of a pleiotropic response to EGF/TGF alpha, and that this involves PKC and de novo synthesis of polypeptides associated with system y+ transport activity.	Arginine	33-41	epidermal growth factor	Homo sapiens	89-92
7576102-1	1995	Murine p53 containing an Arg--&gt;Leu substitution at amino acid 172 possesses many properties characteristic of wild-type p53, including the ability to induce p21/WAF/Cip1 and apoptosis.	Arginine	25-28	transformation related protein 53, pseudogene	Mus musculus	7-10
8562067-7	1995	Amino acid analysis, Edman degradation, and FAB-MS identified T11 as the N-blocked decapeptide pyro-Gln-Pro-Val-Trp-Gln-Asp-Glu-Gly-Gln-Arg derived from the N-terminus of pZPC.	Arginine	136-139	CD2 molecule	Homo sapiens	62-65
7673217-9	1995	A systematic analysis of the region between the sixth cysteine residue and Leu-47 showed that the low affinity of hEGF for the chicken EGF receptor is mainly due to the presence of Arg-45.	Arginine	181-184	epidermal growth factor	Homo sapiens	114-118
7673217-11	1995	This indicates that in hEGF Arg-45 may play an important role in receptor binding.	Arginine	28-31	epidermal growth factor	Homo sapiens	23-27
7588717-9	1995	The deduced amino acid sequence of hG1.16 was identical to rat ribosomal protein L37 that contained 97 amino acids, many of which are highly positively charged (15 arginine and 14 lysine residues with a predicted M(r) of 11,065).	Arginine	164-172	ribosomal protein L37	Homo sapiens	35-41
8581564-6	1995	The lethal effects induced by gp120 involve activation of L-arginine-nitric oxide (NO) pathway since these were prevented by haemoglobin (10 microM), a NO-trapping agent, and by D-arginine (1 mM), the less active enantiomer of the endogenous precursor of NO synthesis.	Arginine	58-68	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	30-35
7642551-7	1995	Replacement of three FKBP13 surface residues (Gln-50, Ala-95, and Lys-98) with the corresponding homologous FKBP12 residues (Arg-42, His-87, and Ile-90) generates an FKBP13 variant that is equivalent to FKBP12 in its affinity for FK506, rapamycin, and calcineurin.	Arginine	125-128	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	108-114
7639510-5	1995	pK2 is clearly dominated by Arg134 in the modified shark enzyme and can be assigned to surface arginine residues.	Arginine	95-103	prokineticin 2	Bos taurus	0-3
8548481-3	1995	EDRF production in A6 cells was tested by application of its substrate L-arginine.	Arginine	71-81	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
7576611-5	1995	A 75 kD recombinant protein, ProNectin F, containing 13 copies of the cell recognition epitope of fibronectin, Val-Thr-Gly-Arg-Gly-Asp-Ser-Pro-Ala-Ser, vigorously supported blastocyst outgrowth.	Arginine	123-126	fibronectin 1	Mus musculus	98-109
16214096-2	2005	One of these modifications, citrullination, is the result of arginine deimination operated by an enzyme, peptidylarginine deiminase (PAD), whose activity is under strict genetic control.	Arginine	61-69	peptidyl arginine deiminase 4	Homo sapiens	133-136
15972892-4	2005	The results show that substitution of Gln-66, Arg-111, Glu-133, or Tyr-143 results in a &gt;800-fold decrease in affinity, demonstrating these four amino acids are essential for carbohydrate recognition by the CD-MPR.	Arginine	46-49	mannose-6-phosphate receptor, cation dependent	Homo sapiens	210-216
7628866-4	1995	Ras alterations were detected in the H-ras gene in 3 tumors, 2 of which harbored a codon-13 (Gly--&gt;Arg) and one a codon-12 (Gly--&gt;Ser) point mutation.	Arginine	102-105	HRas proto-oncogene, GTPase	Homo sapiens	37-42
16133267-1	2005	The role of the outermost three charged residues of Domain IV/S4 in controlling gating of Ca(v)3.2 was investigated using single substitutions of each arginine with glutamine, cysteine, histidine, and lysine in a Flp-In-293 cell line, in which expression levels could be compared.	Arginine	151-159	immunoglobulin lambda variable 7-43	Homo sapiens	90-98
7615511-3	1995	In this study, purified carboxypeptidase M efficiently released the COOH-terminal arginine residue from EGF with a Km = 56 microM, kcat = 388 min-1, and kcat/Km = 6.9 microM-1 min-1.	Arginine	82-90	epidermal growth factor	Canis lupus familiaris	104-107
7619077-15	1995	The findings indicate that Arg-104 is involved in Fru-6-P binding in the PFK-2 domain and that it might also bind citrate.	Arginine	27-30	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	73-78
16131491-0	2005	A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families.	Arginine	112-120	serine/threonine kinase 24	Homo sapiens	143-146
16131491-5	2005	Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4).	Arginine	18-21	serine/threonine kinase 24	Homo sapiens	150-155
8589213-1	1995	Resistance to activated protein C (APC resistance) due to the factor V mutation 506 Arg--&gt;Gln (factor V Leiden) is the most prevalent inherited risk factor for venous thromboembolism.	Arginine	84-87	coagulation factor V	Homo sapiens	98-113
16131491-5	2005	Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4).	Arginine	18-21	serine/threonine kinase 24	Homo sapiens	157-160
16217033-1	2005	The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and Cys of certain eukaryotic proteins, yielding N-terminal Arg that can act as a degradation signal for the ubiquitin-dependent N-end rule pathway.	Arginine	17-20	arginyltransferase 1	Homo sapiens	4-8
8586639-1	1995	Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase, generating citrulline as another product, which can be recycled to arginine by argininosuccinate synthetase and argininosuccinate lyase.	Arginine	38-46	argininosuccinate lyase	Rattus norvegicus	185-208
16217033-1	2005	The ATE1-encoded Arg-transferase mediates conjugation of Arg to N-terminal Asp, Glu, and Cys of certain eukaryotic proteins, yielding N-terminal Arg that can act as a degradation signal for the ubiquitin-dependent N-end rule pathway.	Arginine	57-60	arginyltransferase 1	Homo sapiens	4-8
8586639-1	1995	Nitric oxide (NO) is synthesized from arginine by nitric oxide synthase, generating citrulline as another product, which can be recycled to arginine by argininosuccinate synthetase and argininosuccinate lyase.	Arginine	140-148	argininosuccinate lyase	Rattus norvegicus	185-208
8586639-11	1995	These results show that argininosuccinate synthetase and argininosuccinate lyase are expressed both tissue-specifically and ubiquitously, and that practically all tissues have activities to convert citrulline to arginine.	Arginine	212-220	argininosuccinate lyase	Rattus norvegicus	57-80
16185069-0	2005	Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.	Arginine	8-16	dihydrodipicolinate synthase	Escherichia coli	73-101
7738200-4	1995	Sequencing of the FBN1 gene revealed a heterozygous C to T transition at nucleotide 8176 resulting in the substitution of a tryptophan for an arginine (R2726W), at a site immediately adjacent to a consensus sequence recognized by a cellular protease.	Arginine	142-150	fibrillin 1	Homo sapiens	18-22
7739539-5	1995	Substitution of an atypical tyrosine in the basic region of ADD1/SREBP1 to an arginine found in most bHLH protein causes a restriction to only E-box binding.	Arginine	78-86	sterol regulatory element binding transcription factor 1	Homo sapiens	65-71
16511187-1	2005	Agmatine, which results from the decarboxylation of L-arginine by arginine decarboxylase, is a metabolic intermediate in the biosynthesis of putresine and higher polyamines (spermidine and spermine).	Arginine	52-62	antizyme inhibitor 2	Homo sapiens	66-88
16218877-3	2005	iNOS and arginase are L-arginine-metabolizing enzymes involved in the regulation of inflammatory processes, with NO contributing to innate immunity.	Arginine	22-32	inositol-3-phosphate synthase 1	Homo sapiens	0-4
7739539-6	1995	Conversely, substitution of a tyrosine for the equivalent arginine in another bHLH protein, upstream stimulatory factor, allows this factor to acquire a dual binding specificity similar to that of ADD1/SREBP1.	Arginine	58-66	sterol regulatory element binding transcription factor 1	Homo sapiens	202-208
7739539-7	1995	Promoter activation by ADD1/SREBP1 through the carbohydrate response element E box is not sensitive to the tyrosine-to-arginine mutation, while activation through SRE-1 is completely suppressed.	Arginine	119-127	sterol regulatory element binding transcription factor 1	Homo sapiens	28-34
8542540-7	1995	Additionally, experiments of C5a-induced response with N-Arg were repeated in the presence of L-arginine (L-Arg; the precursor of nitric oxide synthesis) or with systemic administration of superoxide dismutase (SOD).	Arginine	106-111	complement C5	Rattus norvegicus	29-32
16115814-4	2005	Disruption of pas1+ causes defects in arginine and leucine uptake that are remarkably similar to Deltatsc1 and Deltatsc2, whereas Deltapas1Deltatsc1 and Deltapas1Deltatsc2 double mutants have more severe amino acid uptake defects.	Arginine	38-46	AAA family ATPase peroxin 1	Saccharomyces cerevisiae S288C	14-18
8542540-8	1995	RESULTS: (1) C5a induces a dose-dependent vasodilation in the small intestine, and the maximal vasodilation occurs in A3 arterioles at C5a concentration of 10(-12) M; (2) N-Arg inhibits the Ach-induced vasodilation in the rat small intestine; and (3) L-Arg or SOD partially reverses the inhibitory effect of N-Arg.	Arginine	251-256	complement C5	Rattus norvegicus	13-16
8541699-3	1995	Enzyme activity was determined in vitro with the specific substrates Z-Arg-Arg-MCA for cathepsin B, Z-Phe-Arg-MCA for cathepsin B + L, and Arg-MCA for cathepsin H.	Arginine	75-78	cathepsin B	Rattus norvegicus	87-98
8541699-3	1995	Enzyme activity was determined in vitro with the specific substrates Z-Arg-Arg-MCA for cathepsin B, Z-Phe-Arg-MCA for cathepsin B + L, and Arg-MCA for cathepsin H.	Arginine	75-78	cathepsin B	Rattus norvegicus	87-98
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	89-92	mutL homolog 1	Homo sapiens	61-65
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	93-96	mutL homolog 1	Homo sapiens	61-65
7672445-8	1995	Since this aminopeptidase-B was able in vitro to trim out N-terminal Arg and/or Lys residues from peptides mimicking processing intermediates, it is proposed that this enzyme may be involved in propeptide and proprotein processing mechanisms in the course of spermatid differentiation.	Arginine	69-72	arginyl aminopeptidase	Rattus norvegicus	11-27
16199549-4	2005	The median age of onset was 41, 36, and 32 years for MSH2 or MLH1 mutation carriers with arg/arg, arg/pro, and pro/pro genotypes, respectively.	Arginine	93-96	mutL homolog 1	Homo sapiens	61-65
15849777-3	2005	When synthesizing the hexapeptide incorporating Gly, Arg(Pbf), Asn(Mtt), Asp(OtBu) or Cys(Acm) for Xaa, considerable amounts of aspartimide-related by-products were to be expected.	Arginine	53-56	zinc finger protein 395	Homo sapiens	57-60
7536925-7	1995	One clone that binds to both Src and Abl SH3 domains through a common site exhibits reversed binding orientation, in that an arginine indispensable for binding to all tested SH3 domains occurs at the C terminus.	Arginine	125-133	Rous sarcoma oncogene	Mus musculus	29-32
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Arginine	11-14	fibronectin 1	Mus musculus	94-105
16030253-4	2005	Mutation of a single arginine residue within the importin-beta binding domain (IBB) disrupted the interaction with importin-beta, but preserved the ability of SPN to bind Xpo1 or TMG caps.	Arginine	21-29	exportin 1	Homo sapiens	171-175
9815990-2	1995	Human plasmin is now used to cleave and, thereby, activate immunoaffinity-purified recombinant human MIS at its monobasic arginine-serine site at residues 427-428.	Arginine	122-130	anti-Mullerian hormone	Homo sapiens	101-104
16009439-3	2005	Citrulline formed as a by-product of the NOS reaction, can be recycled to arginine by successive actions of argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) via the citrulline-NO cycle.	Arginine	74-82	argininosuccinate lyase	Rattus norvegicus	147-170
9815990-3	1995	To avoid the need for exogenous enzymatic cleavage and to simplify purification, we created an arginine-arginine dibasic cleavage site (MIS RR) using site-directed mutagenesis to change the serine at position 428 (AGC) to an arginine (cGC).	Arginine	95-103	anti-Mullerian hormone	Homo sapiens	136-139
9815990-3	1995	To avoid the need for exogenous enzymatic cleavage and to simplify purification, we created an arginine-arginine dibasic cleavage site (MIS RR) using site-directed mutagenesis to change the serine at position 428 (AGC) to an arginine (cGC).	Arginine	104-112	anti-Mullerian hormone	Homo sapiens	136-139
9815990-3	1995	To avoid the need for exogenous enzymatic cleavage and to simplify purification, we created an arginine-arginine dibasic cleavage site (MIS RR) using site-directed mutagenesis to change the serine at position 428 (AGC) to an arginine (cGC).	Arginine	104-112	anti-Mullerian hormone	Homo sapiens	136-139
8529105-8	1995	The mitochondrial electron transport inhibitors, rotenone and thenoyltrifluoroacetone, inhibited respiratory burst, and rotenone suppressed L-arginine flux, implying that mitochondrial-derived oxygen radicals are important mediators in Nramp-regulated signal transduction pathways.	Arginine	140-150	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	236-241
16006651-4	2005	Our mass spectrometric data showed that of 24 lysines and 18 arginines readily susceptible to small chemical reagent modification in native RPA, the three residues Lys-343, Arg-335, and Arg-382, located in DNA binding domain B (DBD-B) of RPA70, were significantly shielded in the hyperphosphorylated protein.	Arginine	173-176	replication protein A1	Homo sapiens	238-243
9383409-3	1995	The first mutations to be detected were found in two sporadic cases that had identical Arg to Pro changes within one EGF-like domain.	Arginine	87-90	epidermal growth factor	Homo sapiens	117-120
7865131-9	1995	The presence of potential processing multibasic sites suggests that small peptides could be generated (particularly a hexapeptide: Arg-Gln-His-Asn-Leu-Arg), as in the case of the SMR1-VA1 protein of R. norvegicus.	Arginine	131-134	submaxillary gland androgen regulated protein 3B	Rattus norvegicus	179-183
16006651-4	2005	Our mass spectrometric data showed that of 24 lysines and 18 arginines readily susceptible to small chemical reagent modification in native RPA, the three residues Lys-343, Arg-335, and Arg-382, located in DNA binding domain B (DBD-B) of RPA70, were significantly shielded in the hyperphosphorylated protein.	Arginine	186-189	replication protein A1	Homo sapiens	238-243
7865131-9	1995	The presence of potential processing multibasic sites suggests that small peptides could be generated (particularly a hexapeptide: Arg-Gln-His-Asn-Leu-Arg), as in the case of the SMR1-VA1 protein of R. norvegicus.	Arginine	151-154	submaxillary gland androgen regulated protein 3B	Rattus norvegicus	179-183
16051612-7	2005	A glutathione S-transferase fusion protein of PRMT8 has type I PRMT activity, catalyzing the formation of omega-NG-monomethylated and asymmetrically omega-NG,NG-dimethylated arginine residues on a recombinant glycine- and arginine-rich substrate.	Arginine	222-230	protein arginine methyltransferase 8	Homo sapiens	46-51
16147988-3	2005	The ssu71-1 and ssu71-2 alleles were cloned and found to encode single amino acid replacements of glycine-363, either glycine to aspartic acid (G363D) or glycine to arginine (G363R).	Arginine	165-173	transcription factor IIF subunit TFG1	Saccharomyces cerevisiae S288C	4-9
7852500-6	1995	Thus, the R384P mutation provides a molecular explanation for the CMO-I deficiency in this patient and suggests that arginine-384 plays a major role in P450aldo function.	Arginine	117-125	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	152-160
7530004-6	1995	The results demonstrate that the metabolism of arginine in macrophages is controlled by TH1/TH2-dependent cytokines and suggest a regulatory role of arginase on the NO synthesis by intracellular substrate depletion.	Arginine	47-55	heart and neural crest derivatives expressed 2	Mus musculus	92-95
16147988-3	2005	The ssu71-1 and ssu71-2 alleles were cloned and found to encode single amino acid replacements of glycine-363, either glycine to aspartic acid (G363D) or glycine to arginine (G363R).	Arginine	165-173	transcription factor IIF subunit TFG1	Saccharomyces cerevisiae S288C	16-21
16164414-6	2005	Wild-type PFK2 and the Lys3-Arg mutant were purified from hypo-osmotically stressed cells and analysed with MALDI-TOF MS for phosphorylation.	Arginine	28-31	homoaconitate hydratase LYS4	Saccharomyces cerevisiae S288C	23-27
8744698-5	1995	On the contrary, the similar change within Arg-Lys-Pro-Val-Thr sequence, derived of 575-589 loop of LF, produces a tetrapeptide Arg-Pro-Val-Thr, that is active as immunosuppressor both in humoral and cellular immune response.	Arginine	43-46	lactotransferrin	Mus musculus	100-102
15831799-6	2005	It should be pointed out that the vasodilator response to ACh was restored in CH and CHT rats to the level obtained in N and NT rats, respectively, by an in vitro L-arginine addition.	Arginine	163-173	solute carrier family 5 member 7	Rattus norvegicus	85-88
7889627-8	1995	RESULTS: A heterozygous TGC to CGC mutation of codon 634 (cysteine to arginine) was found in the PHAEO and medullary thyroid cancer from the MEN 2A patient.	Arginine	70-78	ret proto-oncogene	Homo sapiens	141-147
7775381-7	1995	IHRP was readily cleaved into 85- and 35-kDa fragments when plasma was incubated at 37 degrees C. The cleaved site, Arg-Arg-Leu, was within a proline-rich region.	Arginine	116-119	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-4
7775381-7	1995	IHRP was readily cleaved into 85- and 35-kDa fragments when plasma was incubated at 37 degrees C. The cleaved site, Arg-Arg-Leu, was within a proline-rich region.	Arginine	120-123	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-4
15831799-7	2005	A hypoxia-induced decrease in L-arginine bioavailability resulting from acclimatization at altitude may be involved in this limitation of the NO pathway in CH and CHT rats.	Arginine	30-40	solute carrier family 5 member 7	Rattus norvegicus	163-166
15998779-11	2005	CONCLUSIONS: We conclude that two homozygous missense LMNA mutations involving the arginine 527 and alanine 529 residues cause MAD with subtle variations in phenotype.	Arginine	83-91	lamin A/C	Homo sapiens	54-58
7989306-2	1994	The active site of pig kidney fructose-1,6-bisphosphatase (EC 3.1.3.11) is shared between subunits, Arg-243 of one chain interacting with fructose-1,6-bisphosphate or fructose-2,6-bisphosphate in the active site of an adjacent chain.	Arginine	100-103	fructose-bisphosphatase 1	Sus scrofa	30-57
7989306-6	1994	The differences in properties of the mutant enzyme indicate the key importance of Arg-243 in the function of fructose-1,6-bisphosphatase and confirm on a functional basis the shared active site in this important metabolic enzyme.	Arginine	82-85	fructose-bisphosphatase 1	Sus scrofa	109-136
16135198-5	2005	Among all pre-treatment isolates, the dhfr triple mutation (Ile-51 + Arg-59 + Asn-108) was detected in 47%.	Arginine	69-72	dihydrofolate reductase	Homo sapiens	38-42
7696460-8	1994	These included a salt link between arginine L34 and one of fluorescein"s enolate oxygen atoms, a hydrogen bond between histidine L27d and the second enolic group, a hydrogen bond between tyrosine L32 and the phenylcarboxylate group, and two medium range (approximately 5 A) electrostatic interactions with lysine L50 and arginine H52.	Arginine	35-43	ribosomal protein L34	Homo sapiens	44-47
15965234-6	2005	The hybrid domain/PSI interface involves the burial of an Arg residue, and contacts between PSI and I-EGF1 are mainly mediated by well conserved Arg and Trp residues.	Arginine	58-61	G elongation factor mitochondrial 1	Homo sapiens	102-106
15965234-6	2005	The hybrid domain/PSI interface involves the burial of an Arg residue, and contacts between PSI and I-EGF1 are mainly mediated by well conserved Arg and Trp residues.	Arginine	145-148	G elongation factor mitochondrial 1	Homo sapiens	102-106
15975930-11	2005	These data demonstrated that the proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for recognition and cleavage of von Willebrand factor between amino acid residues Asp(1595) and Arg(1668).	Arginine	229-232	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	71-79
7957246-8	1994	Determination of the N-terminal amino acid sequence of human IGF-II before and after digestion with DAP-I showed that DAP-I cleaved Ala-Tyr, terminating at Arg-Pro-; the rat IGF-II species beginning with Tyr-Arg-Pro-Ser- was resistant to digestion.	Arginine	156-159	insulin like growth factor 2	Homo sapiens	61-67
7957246-8	1994	Determination of the N-terminal amino acid sequence of human IGF-II before and after digestion with DAP-I showed that DAP-I cleaved Ala-Tyr, terminating at Arg-Pro-; the rat IGF-II species beginning with Tyr-Arg-Pro-Ser- was resistant to digestion.	Arginine	208-211	insulin like growth factor 2	Homo sapiens	61-67
16085056-4	2005	Although a small intracellular pool exists in CAD cells, the lack of mRNA for argininosuccinate synthase (AS), a rate limiting enzyme for arginine recycling, suggests that intracellular pools are not re-supplied by this mechanism in this sub-class of neurons.	Arginine	138-146	argininosuccinate synthase 1	Homo sapiens	106-108
16185406-0	2005	[The regulatory effects of arginine on hepatic insulin-like growth factor-1 secretion in rats and its implication].	Arginine	27-35	insulin-like growth factor 1	Rattus norvegicus	47-75
7525260-3	1994	Release of EGF into the milk requires the hydrolysis of the EGF precursor at Arg-X cleavage sites.	Arginine	77-80	epidermal growth factor	Mus musculus	11-14
7523101-6	1994	L-Arginine (10(-2) M), a precursor of NO enhances basal GnRH secretion.	Arginine	0-10	gonadotropin releasing hormone 1	Mus musculus	56-60
16185406-1	2005	OBJECTIVE: To explore the regulatory effect of arginine on the secretion of hepatic insulin-like growth factor-1 (IGF-I), and the mechanism of enhancing the immune function by arginine.	Arginine	47-55	insulin-like growth factor 1	Rattus norvegicus	84-112
16185406-1	2005	OBJECTIVE: To explore the regulatory effect of arginine on the secretion of hepatic insulin-like growth factor-1 (IGF-I), and the mechanism of enhancing the immune function by arginine.	Arginine	47-55	insulin-like growth factor 1	Rattus norvegicus	114-119
7915716-0	1994	Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone.	Arginine	91-99	gonadotropin releasing hormone receptor	Mus musculus	27-66
16185406-16	2005	The expression of hepatic IGF-I mRNA: The relative value of IGF-I mRNA was 1.19 +/- 0.06, 1.08 +/- 0.06 and 1.29 +/- 0.06 in NC, WC and Arg, respectively, while the value in WC was lower than that in NC (P &lt; 0.05) group, and that in Arg group was much higher than that in WC group (P &lt; 0.01).	Arginine	136-139	insulin-like growth factor 1	Rattus norvegicus	26-31
16185406-16	2005	The expression of hepatic IGF-I mRNA: The relative value of IGF-I mRNA was 1.19 +/- 0.06, 1.08 +/- 0.06 and 1.29 +/- 0.06 in NC, WC and Arg, respectively, while the value in WC was lower than that in NC (P &lt; 0.05) group, and that in Arg group was much higher than that in WC group (P &lt; 0.01).	Arginine	236-239	insulin-like growth factor 1	Rattus norvegicus	26-31
16185406-18	2005	The IGF-I level in the supernatant of cultured hepatocytes: When Arg concentration was 0.0750, 0.7500, 7.5000 mmol/L in the culture medium, the IGF-I level in the supernatant of hepatic cell medi-um was obviously higher than that in the medium without arginine (P &lt; 0.01).	Arginine	65-68	insulin-like growth factor 1	Rattus norvegicus	4-9
16185406-18	2005	The IGF-I level in the supernatant of cultured hepatocytes: When Arg concentration was 0.0750, 0.7500, 7.5000 mmol/L in the culture medium, the IGF-I level in the supernatant of hepatic cell medi-um was obviously higher than that in the medium without arginine (P &lt; 0.01).	Arginine	65-68	insulin-like growth factor 1	Rattus norvegicus	144-149
16185406-19	2005	Although IGF-I level decreased in the culture medium with arginine in the dose of 37.5000 mmol/L, it was still obviously higher than that in the medium without arginine (P &lt; 0.01).	Arginine	58-66	insulin-like growth factor 1	Rattus norvegicus	9-14
16185406-20	2005	CONCLUSION: Arginine could also produce the immune enhancing effect by stimulating hepatic IGF-I secretion.	Arginine	12-20	insulin-like growth factor 1	Rattus norvegicus	91-96
15897189-1	2005	The cardiomyopathy (CM)-loop of the heavy chain of class-II myosins begins with a highly conserved Arg residue (whose mutation in human beta-cardiac myosin II results in familial hypertrophic cardiomyopathy).	Arginine	99-102	myosin heavy chain 14	Homo sapiens	60-66
8082777-3	1994	Introduction of the multi-copy SSB1 gene into the y7-1 mutant cells suppressed defects in the degradation of X-beta-galactosidase (X = Arg or Pro) observed in the mutant cells.	Arginine	135-138	splA/ryanodine receptor domain and SOCS box containing 1	Homo sapiens	31-35
8058766-7	1994	A synthetic peptide spanning the N-terminal thrombin receptor activation sequence was cleaved by granzyme A at the authentic thrombin cleavage site Leu-Asp-Pro-Arg-Ser.	Arginine	160-163	granzyme A	Mus musculus	97-107
15976236-2	2005	L-arginine transport mediated by cationic amino acid transporters (including CAT-1, CAT-2, CAT-2A, and CAT-2B) is crucial in regulating iNOS activity.	Arginine	0-10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	77-82
8033906-2	1994	Synthetic peptides related to amino acid residues 29-42 of human serum amyloid A (SAA), Tyr-Ile-Gly-Ser-Asp-Lys-Tyr-Phe-His-Ala-Arg-Gly-Asn-Tyr, were found to inhibit the adhesion of human T-lymphocytes and of mouse M4 melanoma cells to surfaces coated with the major cell adhesive glycoproteins of the extracellular matrix, laminin or fibronectin.	Arginine	128-131	fibronectin 1	Mus musculus	336-347
15857830-5	2005	Both the full-length and the nuclease domain of Arg(447) mutants retained their nuclease activities, indicating that failure to kill cells was not a consequence of damage to the endonuclease activity of the enzyme.	Arginine	48-51	nuclease	Escherichia coli	29-37
7798168-10	1994	111, 2341-2351 (1990)] have reported that Pro-11, Gly-170, and Ile-340 in normal human AGT1 were replaced by Leu, Arg, and Met, respectively, in a patient with primary hyperoxaluria type 1.	Arginine	114-117	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	87-91
15857830-5	2005	Both the full-length and the nuclease domain of Arg(447) mutants retained their nuclease activities, indicating that failure to kill cells was not a consequence of damage to the endonuclease activity of the enzyme.	Arginine	48-51	nuclease	Escherichia coli	80-88
15857830-8	2005	Conserved basic residues aligned with Arg(447) have also been found in other nuclease colicins, implying that the processing at this position may be common to other colicins during translocation.	Arginine	38-41	nuclease	Escherichia coli	77-85
15845647-4	2005	The CB2 cDNA 188-189 GG/GG polymorphism predicts the substitution of glutamine at amino acid position 63 by arginine.	Arginine	108-116	cannabinoid receptor 2	Homo sapiens	4-7
7985419-5	1994	Measurements of arg3, arg11 and car1 mRNA under different growth conditions confirm the very weak repression by arginine of the two anabolic genes and show that the induction of arginase synthesis operates at a transcriptional level.	Arginine	112-120	arginase	Saccharomyces cerevisiae S288C	32-36
15843372-7	2005	In vitronectin, GrB cleaves after an Arg-Lys-Asp (RGD) motif, which is part of the integrin-binding site found in matrix proteins.	Arginine	37-40	granzyme B	Homo sapiens	16-19
8011638-5	1994	HLA-B27 wt and HLA-B27 D116F formed relatively stable complexes, with a t1/2 of dissociation on the scale of hours, with appropriate peptides that contained Arg at P2, whereas HLA-B27 E45T required a Gln at P2.	Arginine	157-160	major histocompatibility complex, class I, B	Homo sapiens	0-5
8011638-5	1994	HLA-B27 wt and HLA-B27 D116F formed relatively stable complexes, with a t1/2 of dissociation on the scale of hours, with appropriate peptides that contained Arg at P2, whereas HLA-B27 E45T required a Gln at P2.	Arginine	157-160	major histocompatibility complex, class I, B	Homo sapiens	0-7
8011638-5	1994	HLA-B27 wt and HLA-B27 D116F formed relatively stable complexes, with a t1/2 of dissociation on the scale of hours, with appropriate peptides that contained Arg at P2, whereas HLA-B27 E45T required a Gln at P2.	Arginine	157-160	major histocompatibility complex, class I, B	Homo sapiens	15-22
15644457-0	2005	NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice.	Arginine	46-54	nitric oxide synthase 3, endothelial cell	Mus musculus	0-4
8013463-2	1994	The isolation and characterization of cDNA clones indicate that 9G8 is a novel member of the serine/arginine (SR) splicing factor family because it includes an N-terminal RNA binding domain (RBD) and a C-terminal SR domain.	Arginine	100-108	serine and arginine rich splicing factor 7	Homo sapiens	64-67
8086372-8	1994	Arginine (R) occurred in the CDR2 or CDR3 of VH chains in all pathogens; R was absent in the CDRs of VH chains of non-pathogens.	Arginine	0-8	cerebellar degeneration-related 3	Mus musculus	37-41
15644457-11	2005	NOS3 activity is crucial for the increase in muscle arginine and protein turnover during early endotoxemia.	Arginine	52-60	nitric oxide synthase 3, endothelial cell	Mus musculus	0-4
8086372-8	1994	Arginine (R) occurred in the CDR2 or CDR3 of VH chains in all pathogens; R was absent in the CDRs of VH chains of non-pathogens.	Arginine	10-11	cerebellar degeneration-related 3	Mus musculus	37-41
16075760-11	2005	MPO activity in the L-Arg group obviously decreasd compared with other groups.	Arginine	20-25	myeloperoxidase	Rattus norvegicus	0-3
8170953-4	1994	This sequence is similar to the Arg-His-Gly-Xaa-Arg* sequence of the distantly related acid phosphatases, which catalyze as BPGM similar phosphoryl transfers but to a greater extent.	Arginine	32-35	bisphosphoglycerate mutase	Homo sapiens	124-128
8170953-4	1994	This sequence is similar to the Arg-His-Gly-Xaa-Arg* sequence of the distantly related acid phosphatases, which catalyze as BPGM similar phosphoryl transfers but to a greater extent.	Arginine	48-51	bisphosphoglycerate mutase	Homo sapiens	124-128
15942586-11	2005	Addition of L-arginine restored the angiogenic effect of vascular endothelial growth factor (ratios: 1.13 [rest] and 1.20 [pace]; P &lt; .05) and was associated with increased endothelial cell density, as well as vascular endothelial growth factor, endothelial nitric oxide synthase, and Akt protein levels in the ischemic territory.	Arginine	12-22	AKT serine/threonine kinase 1	Sus scrofa	288-291
15902744-14	2005	Pretreatment with L-arginine before graft harvesting resulted in lower enhancement of tissue levels of MDA and MPO and the differences were significant (4.71+/-1.02 mmol/g vs 8.02+/-3.49 mmol/g, 1.03+/-0.095 U/g vs 1.53+/-0.068 U/g, P&lt;0.05).	Arginine	18-28	myeloperoxidase	Rattus norvegicus	111-114
8157662-3	1994	The amino-terminal domain contains a Ser-Arg-rich stretch and consensus sites for phosphorylation by protein kinase A and p34cdc2 protein kinase.	Arginine	41-44	cyclin dependent kinase 1	Homo sapiens	122-129
15683365-7	2005	The replacement of Trp234 in human GST T1-1 by arginine, found in the rodent enzyme, enhanced the alkyltransferase activity by an order of magnitude with a series of homologous iodoalkanes and some typical GST substrates.	Arginine	47-55	CD2 molecule	Homo sapiens	39-43
7512983-4	1994	Two severe cases have the same mutation, K10-R156:C, at a conserved arginine that we previously showed was mutated to a histidine in two unrelated EH families.	Arginine	68-76	keratin 10	Homo sapiens	41-44
15837307-1	2005	Cleavage of 4-pyrrole phenylacyl TentaGel-appended peptide (5) containing Arg(Pbf) with trifluoroacetic acid/triisopropylsilane/phenol/H2O (90/2/4/4) gives the 4-pyrrole phenylacyl peptide (3).	Arginine	74-77	zinc finger protein 395	Homo sapiens	78-81
8139654-4	1994	This cooperation is probably achieved by specific interactions between the arginine/serine-rich domain of the splicing factor and a similar region in a U1 snRNP-specific protein.	Arginine	75-83	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	152-160
15837307-2	2005	However, cleavage of 4-pyrrole phenylacyl Rink-appended peptide (7) containing Arg(Pbf) using the same reagents furnishes the 4-pyrrolidine phenylacyl peptide (8), which contains the reduced pyrrole ring.	Arginine	79-82	zinc finger protein 395	Homo sapiens	83-86
8135541-13	1994	Reaction of purified porcine OTCase with phenylglyoxal, an arginine-specific reagent, results in complete loss of catalytic activity.	Arginine	59-67	ornithine transcarbamylase	Homo sapiens	29-35
15820746-1	2005	Argininosuccinate synthetase (ASS) is limiting the arginine synthesis and can be stimulated by immunostimulants.	Arginine	51-59	argininosuccinate synthase 1	Homo sapiens	0-28
8135541-14	1994	The decrease in enzymatic activity correlates with the modification of 1 mol of arginine per mole of OTCase monomer.	Arginine	80-88	ornithine transcarbamylase	Homo sapiens	101-107
8026990-7	1994	A comparison of amino acid sequences of HLA-A10 cross-reacting antigens revealed that all of the A10 group antigens share specific amino acids: 142 isoleucine, 144 glutamine, 145 arginine, 149 threonine, and 152 glutamate.	Arginine	179-187	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	97-100
15820746-1	2005	Argininosuccinate synthetase (ASS) is limiting the arginine synthesis and can be stimulated by immunostimulants.	Arginine	51-59	argininosuccinate synthase 1	Homo sapiens	30-33
15701641-0	2005	Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.	Arginine	64-72	BTG3 associated nuclear protein	Mus musculus	17-22
8181209-1	1994	Nitric oxide (NO), previously identified with endothelium derived relaxing factor (EDRF), is thought to play a role in central neurotransmission: it is characterized by high lipid solubility and short half life, and NO-synthase, the enzyme which generates NO from L-arginine, has been found in the central nervous system (CNS), both in neuronal and glial cells.	Arginine	264-274	alpha hemoglobin stabilizing protein	Homo sapiens	46-81
8181209-1	1994	Nitric oxide (NO), previously identified with endothelium derived relaxing factor (EDRF), is thought to play a role in central neurotransmission: it is characterized by high lipid solubility and short half life, and NO-synthase, the enzyme which generates NO from L-arginine, has been found in the central nervous system (CNS), both in neuronal and glial cells.	Arginine	264-274	alpha hemoglobin stabilizing protein	Homo sapiens	83-87
15701641-0	2005	Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif.	Arginine	64-72	transformation related protein 53, pseudogene	Mus musculus	48-51
7819328-2	1994	N-arginine dibasic convertase (NRD convertase) (accession number L27124) is a metalloendopeptidase from rat brain cortex and testis which cleaves peptide substrates on the N-terminus of arginine residues in basic doublets.	Arginine	2-10	nardilysin convertase	Rattus norvegicus	31-45
15701641-3	2005	Here we delineate the minimal domain of SMAR1 (the arginine-serine-rich domain) that is phosphorylated by protein kinase C family proteins and is responsible for p53 interaction, activation, and stabilization within the nucleus.	Arginine	51-59	BTG3 associated nuclear protein	Mus musculus	40-45
15701641-3	2005	Here we delineate the minimal domain of SMAR1 (the arginine-serine-rich domain) that is phosphorylated by protein kinase C family proteins and is responsible for p53 interaction, activation, and stabilization within the nucleus.	Arginine	51-59	transformation related protein 53, pseudogene	Mus musculus	162-165
15695505-2	2005	Arginines B13 and B17 are each chelated by an aspartic acid/glutamic acid pair and by isoleucine B20, which, offset by a one-quarter helix turn from a straight line connecting the arginines, interacts with a cluster of hydrophobic amino acids.	Arginine	0-9	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	10-13
8186357-5	1994	This is followed by the formation of an ester linkage between the active site serine residue of the protease and the arginine 393 residue of the cleaved antithrombin molecule.	Arginine	117-125	serpin family C member 1	Homo sapiens	153-165
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Arginine	4-12	epidermal growth factor	Homo sapiens	128-131
7779404-8	1994	The arginine at position 41 is the most critical residue and its full hydrogen-bonding capacity is needed for strong binding of EGF/TGF-alpha to the EGF-receptor.	Arginine	4-12	epidermal growth factor	Homo sapiens	149-152
15695505-2	2005	Arginines B13 and B17 are each chelated by an aspartic acid/glutamic acid pair and by isoleucine B20, which, offset by a one-quarter helix turn from a straight line connecting the arginines, interacts with a cluster of hydrophobic amino acids.	Arginine	180-189	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	10-13
15722353-5	2005	Sequence analyses of the Npr2 gene in cn/cn mice revealed a T to G transversion leading to the amino acid substitution of highly conserved Leu with Arg in the guanylyl cyclase domain.	Arginine	148-151	natriuretic peptide receptor 2	Mus musculus	25-29
8188629-2	1994	The antibody was raised against the phosphorylated synthetic peptide, Lys-Lys-Arg-Pro-Gln-Arg-Ala-Thr-phospho-Ser-Asn-Val-Phe-Cys (residues 11-22 of the myosin light chain).	Arginine	78-81	myosin heavy chain 14	Homo sapiens	153-159
15805117-4	2005	Mutation analysis suggests that the Arg-5 and Lys-110 residues on the PCNA back side are the contact points of the two homotrimers in the doublet.	Arginine	36-39	proliferating cell nuclear antigen	Homo sapiens	70-74
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	Arginine	231-241	interleukin 1 alpha	Homo sapiens	0-4
7505803-7	1994	IL-1-induced cGMP in HSVSMC was also independent of tetrahydrobiopterin and extracellular L-arginine, as it was not affected by 2,4-diamino-6-hydroxyprytimidine, an inhibitor of tetrahydrobiopterin biosynthesis, and was similar in L-arginine-free and L-arginine-containing media.	Arginine	231-241	interleukin 1 alpha	Homo sapiens	0-4
15807891-9	2005	Patients and controls were genotyped for a single nucleotide polymorphism (C/A transversion) in the third base of codon 31 of p21, which leads to a serine (Ser)/arginine (Arg) substitution.	Arginine	161-169	H3 histone pseudogene 16	Homo sapiens	126-129
15807891-9	2005	Patients and controls were genotyped for a single nucleotide polymorphism (C/A transversion) in the third base of codon 31 of p21, which leads to a serine (Ser)/arginine (Arg) substitution.	Arginine	171-174	H3 histone pseudogene 16	Homo sapiens	126-129
15751964-5	2005	The overexpression studies reveal that substitution of 3BP2-Tyr(183), Tyr(446), or Arg(486) in the SH2 domain suppresses TCR-mediated activation of NFAT.	Arginine	83-86	T cell receptor alpha variable 6-3	Mus musculus	121-124
7907140-10	1994	Thymine replaced cytosine, which altered a CGG arginine codon to a TGG tryptophan codon, rendering the AMH molecule unstable.	Arginine	47-55	anti-Mullerian hormone	Homo sapiens	103-106
15751964-10	2005	Furthermore, point mutation of Arg(486) in the 3BP2-SH2 domain that couples ZAP-70 to LAT dramatically reduces NFAT activation.	Arginine	31-34	zeta-chain (TCR) associated protein kinase	Mus musculus	76-82
15652350-3	2005	In addition to a basic lysine and acidic serine-rich (BA) domain and a zinc knuckle-like motif, CIR has an arginine/serine dipeptide repeat (RS) domain in its C terminal region.	Arginine	107-115	corepressor interacting with RBPJ, CIR1	Homo sapiens	96-99
8302588-4	1994	During the neoplastic progression a mutation was shown to occur in p53 gene at codon 130 (AAG &gt; AGG; Lys &gt; Arg) in a single cell which expanded and gave rise to a predominant subpopulation.	Arginine	113-116	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	67-70
8300158-8	1993	In summary, the present results show that activation of microglial cells by rIFN-gamma and LPS induce the production of nitric oxide (NO) by these cells via an L-arginine dependent pathway.	Arginine	160-170	interferon gamma	Rattus norvegicus	76-86
15699387-3	2005	The authors have identified the arginine 1845 tryptophan mutation found in the Swedish families in two isolated Belgian cases, indicating a critical role for myosin residue arginine 1845.	Arginine	32-40	myosin heavy chain 14	Homo sapiens	158-164
7902568-8	1993	The mutation at position 723, which changes the amino acid sequence from Arg to Cys at residue 220, showed complete association with the PGM1 2/1 protein polymorphism: DNA from individuals showing the PGM1 1 isozyme carried the Arg codon CGT, whereas individuals showing the PGM1 2 isozyme carried the Cys codon TGT.	Arginine	73-76	phosphoglucomutase 1	Homo sapiens	137-141
7902568-8	1993	The mutation at position 723, which changes the amino acid sequence from Arg to Cys at residue 220, showed complete association with the PGM1 2/1 protein polymorphism: DNA from individuals showing the PGM1 1 isozyme carried the Arg codon CGT, whereas individuals showing the PGM1 2 isozyme carried the Cys codon TGT.	Arginine	73-76	phosphoglucomutase 1	Homo sapiens	201-205
7902568-8	1993	The mutation at position 723, which changes the amino acid sequence from Arg to Cys at residue 220, showed complete association with the PGM1 2/1 protein polymorphism: DNA from individuals showing the PGM1 1 isozyme carried the Arg codon CGT, whereas individuals showing the PGM1 2 isozyme carried the Cys codon TGT.	Arginine	73-76	phosphoglucomutase 1	Homo sapiens	201-205
15699387-3	2005	The authors have identified the arginine 1845 tryptophan mutation found in the Swedish families in two isolated Belgian cases, indicating a critical role for myosin residue arginine 1845.	Arginine	173-181	myosin heavy chain 14	Homo sapiens	158-164
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	77-80	heme oxygenase 1	Homo sapiens	25-29
7906075-3	1993	EDRF production was blunted in the absence of extracellular L-arginine and in the presence of N omega-nitro-L-arginine (L-NAG; 200 microM).	Arginine	60-70	alpha hemoglobin stabilizing protein	Mus musculus	0-4
7906075-4	1993	Inhibition of endothelial EDRF production by removal of arginine or addition of L-NAG was associated with a significant decrease of renin secretion from the cocultures while the same regimen had no effect on renin secretion from JG cells alone.	Arginine	56-64	alpha hemoglobin stabilizing protein	Mus musculus	26-30
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Arginine	128-136	fibrillin 1	Homo sapiens	91-102
8134310-0	1993	Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain.	Arginine	92-95	neuropeptide FF-amide peptide precursor	Rattus norvegicus	105-109
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Arginine	128-136	fibrillin 1	Homo sapiens	191-202
15517394-7	2005	Our results establish that treatment of cultured human dermal fibroblasts with recombinant fibrillin-1 fragments containing the arginine-glycine-aspartic acid (RGD) integrin-binding motif of fibrillin-1 induces up-regulation of MMP-1 and MMP-3.	Arginine	128-136	matrix metallopeptidase 1	Homo sapiens	228-233
15738658-11	2005	Interestingly, real-time RT-PCR analysis showed that hFOB cultured on hydrophobic substrata, which have downregulated alphav and beta3 integrin subunits, displayed greater steady state mRNA levels of osteopontin, an extracellular matrix (ECM) protein containing the Arg-Gly-Asp (RGD) integrin recognition sequence, than did cells cultured on hydrophilic substrata.	Arginine	266-269	secreted phosphoprotein 1	Homo sapiens	200-211
7692602-3	1993	The dU2AF50 protein is closely related to its mammalian counterpart and contains three carboxyl-terminal ribonucleoprotein consensus sequence RNA binding domains and an amino-terminal arginine- and serine-rich (R/S) domain.	Arginine	184-192	U2 small nuclear riboprotein auxiliary factor 50	Drosophila melanogaster	4-11
15598783-6	2004	However, for p21 polymorphism, the frequencies of p21 Ser/Ser, Ser/Arg and Arg/Arg were 52 (26.0%), 85 (42.5%), 63 (31.5%) in case patients, 48 (26.5%), 82 (45.3%), 51 (28.2%) in BPH patients, and 76 (30.8%), 119 (48.2%), 52 (21.1%) in controls, respectively.	Arginine	75-78	H3 histone pseudogene 16	Homo sapiens	13-16
8218206-5	1993	Tyr-150, Arg-151, and Asp-211 of the mECI are the only amino acids with protic side chains conserved within the enzymes with isomerase activity (pTFE and FadB).	Arginine	9-12	enoyl-Coenzyme A delta isomerase 1	Mus musculus	37-41
15598783-6	2004	However, for p21 polymorphism, the frequencies of p21 Ser/Ser, Ser/Arg and Arg/Arg were 52 (26.0%), 85 (42.5%), 63 (31.5%) in case patients, 48 (26.5%), 82 (45.3%), 51 (28.2%) in BPH patients, and 76 (30.8%), 119 (48.2%), 52 (21.1%) in controls, respectively.	Arginine	75-78	H3 histone pseudogene 16	Homo sapiens	13-16
7692847-8	1993	Western blot analysis indicates that one out of these two residues, arginine at residue 578 in the PBP74/CSA sequence of C3H mouse, contributes to the immunogenicity of CSA.	Arginine	68-76	heat shock protein 9	Mus musculus	99-104
7692847-8	1993	Western blot analysis indicates that one out of these two residues, arginine at residue 578 in the PBP74/CSA sequence of C3H mouse, contributes to the immunogenicity of CSA.	Arginine	68-76	heat shock protein 9	Mus musculus	105-108
7692847-8	1993	Western blot analysis indicates that one out of these two residues, arginine at residue 578 in the PBP74/CSA sequence of C3H mouse, contributes to the immunogenicity of CSA.	Arginine	68-76	heat shock protein 9	Mus musculus	169-172
15572678-7	2004	In contrast, we found that Npl3 arginine methylation not only facilitates its own export but also is required for Hrp1p to efficiently exit the nucleus.	Arginine	32-40	nucleosome assembly protein 1 like 3	Homo sapiens	27-31
15572678-7	2004	In contrast, we found that Npl3 arginine methylation not only facilitates its own export but also is required for Hrp1p to efficiently exit the nucleus.	Arginine	32-40	ubiquitin specific peptidase 6	Homo sapiens	114-119
15572678-11	2004	Thus, arginine methylation serves to mask the Npl3p RGG domain for efficient ribonucleoprotein export.	Arginine	6-14	nucleosome assembly protein 1 like 3	Homo sapiens	46-51
15556994-2	2004	These homologous proteins differ at their N and C termini: the C-terminal Met-Leu-Leu in PLN is replaced by Arg-Ser-Tyr-Gln-Tyr in SLN.	Arginine	108-111	sarcolipin	Homo sapiens	131-134
8287052-0	1993	Synthetic Arg-Gly-Asp-Ser analogues of the cell recognition site of fibronectin that retain antimetastatic and anti-cell adhesive properties.	Arginine	10-13	fibronectin 1	Mus musculus	68-79
15328353-7	2004	The purified activated DESC1 hydrolyzed synthetic peptide substrates, showing a preference for Arg in the P1 position.	Arginine	95-98	transmembrane protease, serine 11e	Mus musculus	23-28
8242287-9	1993	Preincubation of the vein rings with L-arginine, the precursor of EDRF, did not increase the vasorelaxation in smokers.	Arginine	37-47	alpha hemoglobin stabilizing protein	Homo sapiens	66-70
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	116-119	Serpin 88Ea	Drosophila melanogaster	4-10
8393858-6	1993	However, gp70 expression sufficient to block binding of 125I-gp70 to the receptor in the plasma membrane decreased receptor-mediated arginine uptake by 50%.	Arginine	133-141	embigin	Mus musculus	9-13
8393858-6	1993	However, gp70 expression sufficient to block binding of 125I-gp70 to the receptor in the plasma membrane decreased receptor-mediated arginine uptake by 50%.	Arginine	133-141	embigin	Mus musculus	61-65
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	120-123	Serpin 88Ea	Drosophila melanogaster	4-10
15527779-3	2004	The serpin forms SDS-stable complexes with the enzyme and the RSL of Spn4A is cleaved C-terminally to the sequence -Arg-Arg-Lys-Arg/ in accord with the recognition/cleavage site of furin.	Arginine	120-123	Serpin 88Ea	Drosophila melanogaster	4-10
15922712-0	2004	L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes.	Arginine	0-10	CD247 molecule	Homo sapiens	21-28
8335932-1	1993	Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.	Arginine	77-86	cerebellar degeneration-related 3	Mus musculus	72-76
8335932-6	1993	Among the VH CDR3 of these 10 antibodies, 4 displayed arginine residues as a result of N region additions.	Arginine	54-62	cerebellar degeneration-related 3	Mus musculus	13-17
15922712-3	2004	Here, we provide evidence that availability of the amino acid L-arginine modulates the cycle of internalization and re-expression of CD3zeta and cause T cell dysfunction.	Arginine	62-72	CD247 molecule	Homo sapiens	133-140
15922712-4	2004	T cells stimulated and cultured in presence of L-arginine, undergo the normal cycle of internalization and re-expression of CD3zeta.	Arginine	47-57	CD247 molecule	Homo sapiens	124-131
8377385-2	1993	Since blood viscosity determines the shear force on the endothelium which is a major stimulus to nitric oxide (NO) release, we investigated the hypothesis that renal vasodilation during erythropoietin-induced erythrocytosis is mediated by the L-arginine-NO pathway.	Arginine	243-253	erythropoietin	Rattus norvegicus	186-200
15922712-5	2004	In contrast, T cells stimulated and cultured in absence of L-arginine, present a sustained down-regulation of CD3zeta preventing the normal expression of the TCR, exhibit a decreased proliferation, and a significantly diminished production of IFNgamma, IL5, and IL10, but not IL2.	Arginine	59-69	CD247 molecule	Homo sapiens	110-117
8334698-3	1993	Remarkably, Tra, Tra2, and members of the serine/arginine-rich (SR) family of general splicing factors are sufficient to commit dsx pre-mRNA to female-specific splicing, and individual SR proteins differ significantly in their ability to participate in commitment complex formation.	Arginine	49-57	transformer	Drosophila melanogaster	12-15
15922712-6	2004	The replenishment of L-arginine recovers the expression of CD3zeta.	Arginine	21-31	CD247 molecule	Homo sapiens	59-66
15474286-1	2004	Using a gene trap technique, we identified a murine homologue of the yeast LUC7-like gene (Luc7l), which is a serine-arginine-rich protein (SR protein) that localizes in the nucleus through its arginine-serine-rich domain (RS domain) at the C-terminus and shows a speckled distribution pattern.	Arginine	117-125	Luc7-like	Mus musculus	91-96
15345777-0	2004	Human PAD4 regulates histone arginine methylation levels via demethylimination.	Arginine	29-37	peptidyl arginine deiminase 4	Homo sapiens	6-10
7687436-5	1993	Also this effect was inhibited by antibodies against gp 120, showing the specificity of the activation of the L-Arg-NO pathway subsequent to incubation of astrocytoma cells with the HIV coating protein.	Arginine	110-115	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-59
15345777-5	2004	A decrease of histone Arg methylation, with a concomitant increase of citrullination, requires PAD4 activity in human HL-60 granulocytes.	Arginine	22-25	peptidyl arginine deiminase 4	Homo sapiens	95-99
7686371-0	1993	Rheumatoid factors from patients with rheumatoid arthritis react with tryptophan 60 and 95, lysine 58, and arginine 97, on human beta 2-microglobulin.	Arginine	107-115	beta-2-microglobulin	Homo sapiens	129-149
7686371-4	1993	RESULTS AND CONCLUSION: Major beta 2m residues contributing to RF reactivity were tryptophans at positions 60 and 95, lysine at 58, and arginine at position 97.	Arginine	136-144	beta-2-microglobulin	Homo sapiens	30-37
15345777-7	2004	These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones.	Arginine	68-71	peptidyl arginine deiminase 4	Homo sapiens	24-28
15362892-3	2004	The results of the present studies, using pull-down and mass spectrometry experiments, suggest that A2AR-D2R heteromerization depends on an electrostatic interaction between an Arg-rich epitope from the I3 of the D2R (217RRRRKR222) and two adjacent Asp residues (DD401-402) or a phosphorylated Ser (S374) residue in the C-tail of the A2AR.	Arginine	177-180	adenosine A2a receptor	Homo sapiens	100-104
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	124-134	interferon gamma	Rattus norvegicus	30-46
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	124-134	interferon gamma	Rattus norvegicus	48-57
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	124-134	interferon gamma	Rattus norvegicus	204-213
15362892-3	2004	The results of the present studies, using pull-down and mass spectrometry experiments, suggest that A2AR-D2R heteromerization depends on an electrostatic interaction between an Arg-rich epitope from the I3 of the D2R (217RRRRKR222) and two adjacent Asp residues (DD401-402) or a phosphorylated Ser (S374) residue in the C-tail of the A2AR.	Arginine	177-180	adenosine A2a receptor	Homo sapiens	334-338
15362892-5	2004	Second, a peptide corresponding to the Arg-rich I3 region of the D2R (215VLRRRRKRVN224) and bound to Sepharose was able to pull down both GST-A2ACT and the whole A2AR solubilized from A2AR-tranfected HEK-293 cells.	Arginine	39-42	adenosine A2a receptor	Homo sapiens	162-166
15362892-5	2004	Second, a peptide corresponding to the Arg-rich I3 region of the D2R (215VLRRRRKRVN224) and bound to Sepharose was able to pull down both GST-A2ACT and the whole A2AR solubilized from A2AR-tranfected HEK-293 cells.	Arginine	39-42	adenosine A2a receptor	Homo sapiens	184-188
15362892-6	2004	Finally, mass spectometry and pull-down data showed that the Arg-rich D2R epitope binds to two different epitopes from the C-terminal part of the A2AR, containing the two adjacent Asp residues or the phosphorylated Ser residue (388HELKGVCPEPPGLDDPLAQDGAVGS412 and 370SAQEpSQGNT378).	Arginine	61-64	adenosine A2a receptor	Homo sapiens	146-150
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	235-245	interferon gamma	Rattus norvegicus	30-46
8281294-5	1993	Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS.	Arginine	235-245	interferon gamma	Rattus norvegicus	48-57
15252023-4	2004	A structure-based sequence alignment was performed that predicts that domain 5 contains the four conserved key residues (Gln, Arg, Glu, and Tyr) identified as essential for carbohydrate recognition by the CD-MPR and domains 3 and 9 of the CI-MPR, but lacks two cysteine residues predicted to form a disulfide bond within the binding pocket.	Arginine	126-129	mannose-6-phosphate receptor, cation dependent	Homo sapiens	205-211
8380004-0	1993	Arginine-79 in the first epidermal growth factor domain of factor VII is essential for the interaction with tissue factor.	Arginine	0-8	coagulation factor III, tissue factor	Homo sapiens	108-121
15252023-4	2004	A structure-based sequence alignment was performed that predicts that domain 5 contains the four conserved key residues (Gln, Arg, Glu, and Tyr) identified as essential for carbohydrate recognition by the CD-MPR and domains 3 and 9 of the CI-MPR, but lacks two cysteine residues predicted to form a disulfide bond within the binding pocket.	Arginine	126-129	insulin like growth factor 2 receptor	Homo sapiens	239-245
15339660-4	2004	We show that peptidyl arginine deiminase 4 (PADI4) specifically deiminates, arginine residues R2, R8, R17, and R26 in the H3 tail.	Arginine	22-30	peptidyl arginine deiminase 4	Homo sapiens	44-49
8389256-8	1993	The cell line PLC/PRF/5 that showed p53 mutation at codon 249 (G:C--&gt;T:A) with substitution of serine for arginine was derived from a South African patient.	Arginine	109-117	heparan sulfate proteoglycan 2	Homo sapiens	14-17
8464896-1	1993	We recently reported the detection of a heterozygous G--&gt;C point mutation at codon 280 of p53 in nasopharyngeal carcinoma, which causes an Arg--&gt;Thr substitution.	Arginine	142-145	transformation related protein 53, pseudogene	Mus musculus	93-96
8320138-6	1993	Arginine in position 74 of the DRB3 gene product (i.e., HLA-DRB3*0101) was significantly more frequent in Graves" patients than in controls.	Arginine	0-8	major histocompatibility complex, class II, DR beta 3	Homo sapiens	56-64
7679680-8	1993	The synthetic peptide Gly-Arg-Gly-Asp-Ser (GRGDS), which competes for the binding of fibronectin to its cell receptors and inhibits the adhesion of endothelial cells to substrates, arrested the elongation of developing microvessels causing regression and inhibition of angiogenesis.	Arginine	26-29	fibronectin 1	Rattus norvegicus	85-96
8464162-6	1993	In addition, another two types of a point mutation reducing ChE activity were reported on K variant (Ala-539--&gt;Thr) and a case of (Gly-365--&gt;Arg) in a patient with liver cirrhosis.	Arginine	147-150	butyrylcholinesterase	Homo sapiens	60-63
7678465-2	1993	The unedited version of GluR6, GluR6Q, encodes a glutamine at position 621 (Q/R site) and exhibits a Ca2+/monovalent ion permeability ratio of 1.2, while the edited version of GluR6, GluR6R, encodes an arginine at position 621 and exhibits a permeability ratio of 0.47.	Arginine	202-210	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	24-29
7678465-2	1993	The unedited version of GluR6, GluR6Q, encodes a glutamine at position 621 (Q/R site) and exhibits a Ca2+/monovalent ion permeability ratio of 1.2, while the edited version of GluR6, GluR6R, encodes an arginine at position 621 and exhibits a permeability ratio of 0.47.	Arginine	202-210	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	31-36
8093241-5	1993	However, it was found that Glu245, which has a pKa of 5.1 in rat cathepsin B, is responsible for the S2-P2 specificity for Arg-containing substrates and controls the pH dependence of their hydrolysis.	Arginine	123-126	cathepsin B	Rattus norvegicus	65-76
8093241-8	1993	While cathepsin B has a 7-fold preference for Phe over Arg at the P2 position of a substrate, binding of the aromatic side chain does not appear to be influenced by Glu245.	Arginine	55-58	cathepsin B	Rattus norvegicus	6-17
8416958-1	1993	Bac5 is a 5-kDa proline- and arginine-rich antibiotic, stored as inactive precursor (proBac5) in the large granules of bovine neutrophils.	Arginine	29-37	cathelicidin-2	Bos taurus	0-4
7682883-0	1993	A mutation (Met--&gt;Arg) in the type I keratin (K14) gene responsible for autosomal dominant epidermolysis bullosa simplex.	Arginine	21-24	keratin 14	Homo sapiens	49-52
15339660-5	2004	Deimination by PADI4 prevents arginine methylation by CARM1.	Arginine	30-38	peptidyl arginine deiminase 4	Homo sapiens	15-20
15339660-6	2004	Dimethylation of arginines prevents deimination by PADI4 although monomethylation still allows deimination to take place.	Arginine	17-26	peptidyl arginine deiminase 4	Homo sapiens	51-56
15350190-11	2004	L-Arginine to L-citrulline conversion assays showed that ATP, EGF and VEGF induced a significant rise in eNOS activity, and this correlates with an ability to induce Ca2+ mobilization and ERK 2 activation.	Arginine	0-10	epidermal growth factor	Homo sapiens	62-65
15308721-5	2004	Remarkably, the recognition of PrP by the anti-mono2 antibodies was strongly influenced by the amino acid present at position 171, i.e., either Gln or Arg.	Arginine	151-154	major prion protein	Ovis aries	31-34
15327772-3	2004	Inhibition of arginine methylation impaired the expression of several cytokine genes, including the signature type 1 and type 2 helper cytokines, interferon gamma, and interleukin-4.	Arginine	14-22	interleukin 4	Mus musculus	168-181
15302922-5	2004	Comparing Spalax with human and mouse p53 revealed an arginine (R) to lysine (K) substitution in Spalax (Arg-174 in human) in the DNA-binding domain, identical to known tumor associated mutations.	Arginine	54-62	transformation related protein 53, pseudogene	Mus musculus	38-41
15302922-5	2004	Comparing Spalax with human and mouse p53 revealed an arginine (R) to lysine (K) substitution in Spalax (Arg-174 in human) in the DNA-binding domain, identical to known tumor associated mutations.	Arginine	105-108	transformation related protein 53, pseudogene	Mus musculus	38-41
15313928-8	2004	L-Arg depletion by tumor-associated myeloid cells blocked the re-expression of CD3zeta in stimulated T cells and inhibited antigen-specific proliferation of OT-1 and OT-2 cells.	Arginine	0-5	CD247 molecule	Homo sapiens	79-86
15225714-6	2004	This suggests the existence of an additional binding site within hMC1R next to that for the core sequence His-d-Phe-Arg-Trp-NH(2).	Arginine	116-119	melanocortin 1 receptor	Homo sapiens	65-70
15313667-13	2004	The activity of MPO in the L-Arg group was obviously decreased as compared with in the other groups.	Arginine	27-32	myeloperoxidase	Rattus norvegicus	16-19
15447819-10	2004	CONCLUSION: L-arginine supplementation could be beneficial to the angiogenesis in the burn wound of the rats with diabetes, as well as to wound healing by increasing the synthesis and the release of VEGF, NO and TGF-beta1 from burn wound and by decreasing the glucose content in the cutaneous tissue of diabetic rats.	Arginine	12-22	vascular endothelial growth factor A	Rattus norvegicus	199-203
15123679-9	2004	These data identify a third loss-of-function polymorphism affecting the human P2X(7) receptor, and since the affected Arg(307) is homologous to those amino acids essential for ATP binding to P2X(1) and P2X(2), it is likely that this polymorphism abolishes the binding of ATP to the extracellular domain of P2X(7).	Arginine	118-121	purinergic receptor P2X 1	Homo sapiens	191-197
8280370-3	1993	Specifically, we found that the highly malignant S49 cell line T-60 contains an Arg--&gt;Gln substitution at residue 246 in exon 7 of p53.	Arginine	80-83	transformation related protein 53, pseudogene	Mus musculus	134-137
1479292-9	1992	A nonsense mutation (Arg 19 Term) in the gene encoding apolipoprotein C-II (apoC-II), the cofactor of LPL, was found to underlie chylomicronemia in the sixth patient who had normal LPL but was apoC-II-deficient.	Arginine	21-24	lipoprotein lipase	Homo sapiens	102-105
15064952-8	2004	Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression, via mechanisms involving membrane hyperpolarization, mitogen-activated protein kinases p42 and p44, phosphatidylinositol 3-kinase, NO and protein kinase C. We have characterized a cell signalling pathway by which hyperinsulinaemia could lead to vasodilatation in human subjects, and which could have implications in patients in whom plasma insulin levels are altered, such as in diabetes mellitus.	Arginine	36-46	cyclin dependent kinase 20	Homo sapiens	225-228
1479292-9	1992	A nonsense mutation (Arg 19 Term) in the gene encoding apolipoprotein C-II (apoC-II), the cofactor of LPL, was found to underlie chylomicronemia in the sixth patient who had normal LPL but was apoC-II-deficient.	Arginine	21-24	lipoprotein lipase	Homo sapiens	181-184
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Mus musculus	51-54
15120633-1	2004	LAT-1/CD98 amino acid transporter expression and activity are induced in hepatic cells deprived of arginine.	Arginine	99-107	solute carrier family 7 member 5	Homo sapiens	0-5
1453445-2	1992	1H nuclear magnetic resonance studies of Dolabella met-cyano myoglobin have revealed that a guanidino NH proton of Arg-E10 is hydrogen-bonded to the Fe-bound CN-.	Arginine	115-118	myoglobin	Homo sapiens	61-70
1453445-3	1992	The role of Arg-E10 as a hydrogen-bond donor for Fe-bound ligand in the present myoglobin appears to be responsible for its relatively high ligand affinity.	Arginine	12-15	myoglobin	Homo sapiens	80-89
15120633-1	2004	LAT-1/CD98 amino acid transporter expression and activity are induced in hepatic cells deprived of arginine.	Arginine	99-107	solute carrier family 7 member 5	Homo sapiens	6-10
1328239-13	1992	The results demonstrate that in addition to Lys-356, Arg-352 is another critical residue in fructose-2,6-bisphosphatase for binding the C-6 phospho group of fructose 2,6-bisphosphate and that Arg-360 binds the C-2 phospho group of fructose 2,6-bisphosphate in the phosphoenzyme.fructose 2,6-bisphosphate complex.	Arginine	53-56	complement C6	Rattus norvegicus	136-139
15120633-3	2004	LAT-1 expression, in contrast to that of CD98 heavy chain 4F2, was actinomycin D sensitive in cells cultured without arginine.	Arginine	117-125	solute carrier family 7 member 5	Homo sapiens	0-5
1328239-13	1992	The results demonstrate that in addition to Lys-356, Arg-352 is another critical residue in fructose-2,6-bisphosphatase for binding the C-6 phospho group of fructose 2,6-bisphosphate and that Arg-360 binds the C-2 phospho group of fructose 2,6-bisphosphate in the phosphoenzyme.fructose 2,6-bisphosphate complex.	Arginine	53-56	complement C2	Rattus norvegicus	210-213
15110758-4	2004	FAST is tethered to mitochondria by a lysine/arginine-rich domain at its carboxyl terminus that is structurally similar to the mitochondrial tethering motifs of monoamine oxidase B and cytochrome b5.	Arginine	45-53	cytochrome b5 type A	Homo sapiens	185-198
1328239-13	1992	The results demonstrate that in addition to Lys-356, Arg-352 is another critical residue in fructose-2,6-bisphosphatase for binding the C-6 phospho group of fructose 2,6-bisphosphate and that Arg-360 binds the C-2 phospho group of fructose 2,6-bisphosphate in the phosphoenzyme.fructose 2,6-bisphosphate complex.	Arginine	192-195	complement C6	Rattus norvegicus	136-139
1357118-2	1992	The natural amino acid at this position (arginine in GluR2 but glutamine in GluR1, GluR3, and GluR4) determines both the ability to pass outward current and the divalent cation permeability of kainate-activated receptor channels.	Arginine	41-49	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	76-81
15064320-5	2004	SRD5A2 gene analysis revealed 2 consecutive mutations in exon 4, each located in a different allele: 1) a T nucleotide deletion, which predicts a frameshift mutation from codon 219, and 2) a missense mutation at codon 227, where the substitution of guanine (CGA) by adenine (CAA) predicts a glutamine replacement of arginine (R227Q).	Arginine	316-324	steroid 5 alpha-reductase 2	Homo sapiens	0-6
1525820-3	1992	It also permits direct visualization of the conservation of arginine as an "anchor" side chain at the second peptide position, which is bound in a potentially HLA-B27-specific pocket and may therefore have a role in the association of HLA-B27 with several diseases.	Arginine	60-68	major histocompatibility complex, class I, B	Homo sapiens	159-166
1525820-3	1992	It also permits direct visualization of the conservation of arginine as an "anchor" side chain at the second peptide position, which is bound in a potentially HLA-B27-specific pocket and may therefore have a role in the association of HLA-B27 with several diseases.	Arginine	60-68	major histocompatibility complex, class I, B	Homo sapiens	235-242
15118362-9	2004	These results suggest that protein methylation activates RyR/Ca(2+) release channels and may participate in the control of intracellular Ca(2+) mobilization in CASM cells by transferring a methyl group to the arginine moiety of the RyR accessory protein, FKBP 12.	Arginine	209-217	FKBP prolyl isomerase 1A pseudogene 1	Homo sapiens	255-262
14970240-4	2004	Western blot analysis demonstrated a significant and dose-dependent reduction of AS protein as a result of AS small interfering RNA treatment with a corresponding diminished capacity to produce basal or stimulated levels of NO, despite saturating levels of arginine in the medium.	Arginine	257-265	argininosuccinate synthase 1	Homo sapiens	81-83
1382056-8	1992	Modification of arginine residues with cyclohexanedione reversibly removed the inhibitory potency of lactoferrin.	Arginine	16-24	lactotransferrin	Rattus norvegicus	101-112
1382056-9	1992	We located by molecular modeling an alpha-helical segment in lactoferrin on the exposed surface of the molecule containing the sequence Arg-X-X-Arg-Lys-X-Arg, which resembles the receptor recognition structure in apolipoprotein E (apoE).	Arginine	136-139	lactotransferrin	Rattus norvegicus	61-72
15179350-4	2004	In E-selectin, exchange from serine to arginine (position 128, S128R) is correlated with early atherosclerosis.	Arginine	39-47	selectin E	Homo sapiens	3-13
15034050-0	2004	Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.	Arginine	118-126	complement C1q A chain	Homo sapiens	65-80
1528899-6	1992	This pattern of cleavage by PC3 is similar, but not identical, to that of the highly B-chain-C-peptide junction-selective type I activity as described by Davidson et al., perhaps due to the presence of a P4 arginine residue near the C-peptide-A-chain junction unique to the rat proinsulins.	Arginine	207-215	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	28-31
1639774-19	1992	Likewise, neutral amino acids in excess inhibit the 4F2-induced uptake of radiolabeled arginine but not leucine in a sodium-dependent manner.	Arginine	87-95	solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog	Xenopus laevis	52-55
15034050-0	2004	Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction.	Arginine	118-126	complement C1q A chain	Homo sapiens	65-68
15034050-6	2004	Because C1q is a charge pattern recognition molecule, we have sequentially targeted arginine and histidine residues in each chain.	Arginine	84-92	complement C1q A chain	Homo sapiens	8-11
15034050-7	2004	Consistent with previous chemical modification studies and the recent crystal structure of gC1q, our results support a central role for arginine and histidine residues, especially Arg(114) and Arg(129) of the ghB module, in the C1q-IgG interaction.	Arginine	136-144	complement C1q A chain	Homo sapiens	92-95
1446389-8	1992	To clarify the involvement of the L-arginine-nitric oxide pathway in these alterations, we studied the effect of exogenous application of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF) and NG-nitro-L-arginine (NOLA), a competitive antagonist of the EDRF-producing enzyme on the vascular responses in vitro.	Arginine	138-148	alpha hemoglobin stabilizing protein	Homo sapiens	167-202
15044002-9	2004	In human GDH isozymes, the 443 site is Arg in hGDH1 and Ser in hGDH2.	Arginine	39-42	glutamate dehydrogenase 1	Homo sapiens	46-51
1378832-1	1992	Nitric oxide, which accounts for the biological activity of endothelium-derived relaxing factor (EDRF), is synthesized in endothelial cells from L-arginine by nitric oxide synthase (NOS).	Arginine	145-155	alpha hemoglobin stabilizing protein	Homo sapiens	60-95
1378832-1	1992	Nitric oxide, which accounts for the biological activity of endothelium-derived relaxing factor (EDRF), is synthesized in endothelial cells from L-arginine by nitric oxide synthase (NOS).	Arginine	145-155	alpha hemoglobin stabilizing protein	Homo sapiens	97-101
14990791-10	2004	Analgesic stimulators of the neuronal arginine/NO/cGMP/PKG/K(ATP)(+) pathway constitute a previously undescribed well defined class of peripheral analgesics with a mechanism of action different from either glucocorticoids or inhibitors of cyclooxygenases.	Arginine	38-46	protein kinase cGMP-dependent 1	Homo sapiens	55-58
1327824-1	1992	L-arginine is considered to be a precursor substance of kyotorphin (tyrosyl-arginine), a [Met5]enkephalin releaser with antinociceptive action.	Arginine	0-10	proenkephalin	Rattus norvegicus	95-105
1378072-5	1992	Binding to fibronectin was blocked by a synthetic peptide containing the sequence Arg-Gly-Asp.	Arginine	82-85	fibronectin 1	Rattus norvegicus	11-22
14769921-0	2004	Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex.	Arginine	44-52	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	77-81
1376926-4	1992	This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine.	Arginine	178-188	solute carrier family 3 member 2	Homo sapiens	83-88
1376926-4	1992	This is based on the following results: (i) Injection of in vitro transcripts from 4F2hc cDNA (4F2hc cRNA) into oocytes stimulates up to 10-fold the sodium-independent uptake of L-arginine and up to 4.1-fold the sodium-dependent uptake of L-leucine.	Arginine	178-188	solute carrier family 3 member 2	Homo sapiens	95-100
1376926-6	1992	(ii) Basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine is completely inhibited by L-leucine in the presence of sodium.	Arginine	66-76	solute carrier family 3 member 2	Homo sapiens	15-20
14769921-2	2004	In this article, we show that the poly(A)(+) RNA-binding proteins Gbp2 and Hrb1, which resemble the serine-arginine-rich (SR) family of splicing factors found in higher eukaryotes, are specifically associated with the yeast TREX complex.	Arginine	107-115	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	66-70
1376926-7	1992	Similarly, the basal and 4F2hc cRNA-stimulated sodium-dependent uptake of L-leucine is entirely inhibited by L-arginine.	Arginine	109-119	solute carrier family 3 member 2	Homo sapiens	25-30
1376926-9	1992	(iv) Both basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine show two additional characteristics of the system y+ transport activity: inhibition of L-arginine uptake by L-homoserine only in the presence of sodium and an increase in the inhibition exerted by L-histidine as the extracellular pH decreased.	Arginine	71-81	solute carrier family 3 member 2	Homo sapiens	20-25
14764716-4	2004	Importantly, the key residue cysteine 417 at the zinc finger domain of IKKgamma has been found to be mutated to arginine (IKKgammaC417R) in a human genetic disorder called the anhydrotic ectodermal dysplasia with immunodeficiency.	Arginine	112-120	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	71-79
1376926-9	1992	(iv) Both basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine show two additional characteristics of the system y+ transport activity: inhibition of L-arginine uptake by L-homoserine only in the presence of sodium and an increase in the inhibition exerted by L-histidine as the extracellular pH decreased.	Arginine	169-179	solute carrier family 3 member 2	Homo sapiens	20-25
1387804-7	1992	This model is in agreement with recent studies of an inactive BPGM variant substituent at an Arg position situated in this positively charged cluster.	Arginine	93-96	bisphosphoglycerate mutase	Homo sapiens	62-66
14747703-0	2004	The impact of Lys--&gt;Arg surface mutations on the crystallization of the globular domain of RhoGDI.	Arginine	23-26	Rho GDP dissociation inhibitor alpha	Homo sapiens	94-100
14560312-5	2004	The exchanges of arginine to histidine, found in two unrelated patients with TRPS I, as well as the exchange of arginine to cysteine, found in another unrelated patient, prevent the translocation of the mutant TRPS1 to the nucleus when ectopically expressed in COS 7 cells.	Arginine	17-25	transcriptional repressor GATA binding 1	Homo sapiens	210-215
1619387-8	1992	One missense mutation in the apoB gene (an Arg----Gln substitution at apoB amino acid 3500) is associated with very poor binding of apoB100 to the cellular LDL receptor.	Arginine	43-46	low density lipoprotein receptor	Homo sapiens	156-168
14560312-5	2004	The exchanges of arginine to histidine, found in two unrelated patients with TRPS I, as well as the exchange of arginine to cysteine, found in another unrelated patient, prevent the translocation of the mutant TRPS1 to the nucleus when ectopically expressed in COS 7 cells.	Arginine	112-120	transcriptional repressor GATA binding 1	Homo sapiens	210-215
1599954-8	1992	The highly conserved Lys36p (pig pepsinogen A numbering) is changed to Arg in porcine progastricsin.	Arginine	71-74	pepsin A	Sus scrofa	33-45
15222685-2	2004	The most common IRS1 variant, a Gly --&gt; Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations.	Arginine	43-46	insulin receptor substrate 1	Homo sapiens	16-20
15222685-2	2004	The most common IRS1 variant, a Gly --&gt; Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations.	Arginine	43-46	insulin receptor substrate 1	Homo sapiens	81-85
1567219-6	1992	Specific removal of the newly formed carboxy-terminal Arg residue from modified rATS by carboxypeptidase B treatment obviates its conversion to native inhibitor coincident with the complete loss of inhibitory activity.	Arginine	54-57	carboxypeptidase B1	Rattus norvegicus	88-106
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	237-240	major prion protein	Ovis aries	73-76
1569192-4	1992	A G to T transition at nucleotide 10038 results in the substitution of Met to an Arg, converting alpha 1-AT into an Arg-Ser protease inhibitor (serpin) that inhibited thrombin and Factor Xa more effectively than antithrombin III.	Arginine	81-84	serpin family C member 1	Homo sapiens	212-228
1573268-0	1992	The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect.	Arginine	119-127	complement C4A (Rodgers blood group)	Homo sapiens	50-54
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	241-244	major prion protein	Ovis aries	73-76
1573268-11	1992	The C4A6 allotype contains a Trp residue at this position in the beta-chain instead of the Arg residue found in all other C4A and C4B allotypes so far characterized.	Arginine	91-94	complement C4A (Rodgers blood group)	Homo sapiens	4-8
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	241-244	major prion protein	Ovis aries	73-76
1573269-0	1992	A single arginine to tryptophan interchange at beta-chain residue 458 of human complement component C4 accounts for the defect in classical pathway C5 convertase activity of allotype C4A6.	Arginine	9-17	complement C4A (Rodgers blood group)	Homo sapiens	183-187
1573269-6	1992	DNA sequencing studies described in a companion paper have suggested that the sole C4A6-specific difference was a Trp for Arg replacement at beta-chain residue 458.	Arginine	122-125	complement C4A (Rodgers blood group)	Homo sapiens	83-87
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	241-244	major prion protein	Ovis aries	73-76
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	241-244	major prion protein	Ovis aries	73-76
15036367-3	2004	The occurrence of scrapie in sheep is influenced by polymorphisms in the PrP gene; in particular, three codons (136, 154 and 171) are important in conditioning the susceptibility/resistance of sheep to the disease, with the Val/Val(136) Arg/Arg(154) Gln/Gln(171) genotype being the most susceptible and the Ala/Ala(136) Arg/Arg(154) Arg/Arg(171), the most resistant one.	Arginine	241-244	major prion protein	Ovis aries	73-76
1313366-2	1992	The Schizosaccharomyces pombe arginine anabolic genes encoding ornithine carbamoyltransferase (arg3) and acetylglutamate kinase/acetylglutamyl-phosphate reductase (arg11) were cloned by functional complementation of S. pombe arg3 and arg11 mutant strains from S. pombe DNA genomic libraries.	Arginine	30-38	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	95-99
1313366-2	1992	The Schizosaccharomyces pombe arginine anabolic genes encoding ornithine carbamoyltransferase (arg3) and acetylglutamate kinase/acetylglutamyl-phosphate reductase (arg11) were cloned by functional complementation of S. pombe arg3 and arg11 mutant strains from S. pombe DNA genomic libraries.	Arginine	30-38	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	225-229
14519104-8	2004	All modified forms of Rtt101p and Cul3p were lost when a single lysine residue in a conserved region near the C-terminus was replaced by an arginine residue.	Arginine	140-148	cullin CUL3	Saccharomyces cerevisiae S288C	34-39
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Arginine	58-66	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	23-27
1572651-8	1992	All of the PSGs except PSG1, PSG4, and PSG8 contained the arginine-glycine-aspartic acid sequence at position 93-95 corresponding to the complementarity determining region 3 of immunoglobulin.	Arginine	58-66	pregnancy specific beta-1-glycoprotein 4	Homo sapiens	29-33
1639630-8	1992	TCC B and I were restricted by HLA-DR molecules, and recognized the mutated p21 ras-derived peptide carrying Arg and Lys at residue 12, respectively.	Arginine	109-112	H3 histone pseudogene 16	Homo sapiens	76-79
1557353-3	1992	The PR264 polypeptide, which contains a typical ribonucleoprotein 80 and an arginine/serine-rich domain, is highly homologous to the Drosophila splicing regulators tra, tra-2, and su(wa) and to the human alternative splicing factor ASF/SF2.	Arginine	76-84	transformer	Drosophila melanogaster	164-167
14648556-5	2004	Arginine 89 of cytokeratin18 plays an important role in intermediate filament assembly.	Arginine	0-8	keratin 18	Homo sapiens	15-28
15090903-2	2004	However, other important aspects of arginine metabolism, such as arginine transport and arginine catabolism via the arginases, arginine decarboxylase or agmatinase, have been less well studied.	Arginine	36-44	antizyme inhibitor 2	Homo sapiens	127-149
14750595-3	2004	Dominant cone-rod dystrophies arising from changes in retGC1 are essentially restricted to mutations in codon 838 and result in the replacement of a conserved arginine residue with either cysteine, histidine or serine.	Arginine	159-167	guanylate cyclase 2D, retinal	Homo sapiens	54-60
16668789-0	1992	Functional Importance of Arginine 64 in Chlamydomonas reinhardtii Phosphoribulokinase.	Arginine	25-33	uncharacterized protein	Chlamydomonas reinhardtii	66-85
14691231-4	2004	The AMP binding site of the gamma(1) CBS1/CBS2 pair, modeled on the structures of the CBS sequences present in the inosine monophosphate dehydrogenase crystal structure, contains three arginine residues 70, 152, and 171 and His151.	Arginine	185-193	Cbs1p	Saccharomyces cerevisiae S288C	37-41
14674748-11	2003	It is suggested that Ser phosphorylation allows protein-protein association by electrostatic stabilization: an obvious negative binding region of Vpu was recognizable by positive residues (Arg and Lys) of the WD domain of beta-TrCP.	Arginine	189-192	beta-transducin repeat containing E3 ubiquitin protein ligase	Homo sapiens	222-231
1372142-2	1992	Using antibodies directed against the C-terminus of gp 120, including the sequence between the two sites, we have shown that nonmutated viral and recombinant gp 160 are cleaved at both sites: the great majority of molecules are cleaved at site 1 (Arg-Glu-Lys-Arg), and gp41 can then associate as an oligomer; a minority of molecules are cleaved at site 2 (Lys-Ala-Lys-Arg-Arg) and the corresponding gp41 appears to present as a monomer.	Arginine	247-250	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	52-58
14523001-3	2003	Cat-1, the transporter for the essential amino acids, arginine and lysine, is one of the up-regulated genes.	Arginine	54-62	GIT ArfGAP 1	Homo sapiens	0-5
1370832-1	1992	Binding of the adhesive ligand fibrinogen and the monoclonal antibody PAC1 to platelet glycoprotein (GP) IIb-IIIa is dependent on cell activation and inhibited by Arg-Gly-Asp (RGD)-containing peptides.	Arginine	163-166	dual specificity phosphatase 2	Mus musculus	70-74
14653737-0	2003	What is so special about Arg 55 in the catalysis of cyclophilin A?	Arginine	25-28	peptidylprolyl isomerase A	Homo sapiens	52-65
1346128-3	1992	To test whether this sequence reflects a conserved function, site-directed mutagenesis was used to replace the codon for Arg298 of asparagine synthetase A, which aligns with an invariant arginine in the Class II aminoacyl tRNA synthetases.	Arginine	187-195	asparagine synthetase A	Escherichia coli	131-154
14596612-8	2003	Mutation of arginine residues in NPY13-36 to alanine abrogated binding to Hsp90.	Arginine	12-20	neuropeptide Y	Homo sapiens	33-41
1539983-4	1992	Within the nitrite reductase promoter region is an fnr-like operator very similar to an operator upstream of a separate anaerobic pathway, that for arginine catabolism in P. aeruginosa.	Arginine	148-156	nitrite reductase small subunit NirD	Pseudomonas stutzeri	11-28
14596612-8	2003	Mutation of arginine residues in NPY13-36 to alanine abrogated binding to Hsp90.	Arginine	12-20	heat shock protein 90 alpha family class A member 1	Homo sapiens	74-79
14532853-12	2003	The addition of L-arginine, which is a substrate for nitric oxide synthase, superimposed on ET-A receptor blockade confers a further decrease in renal vascular resistance, suggesting that the ET and L-arginine-nitric oxide systems are involved in renal hemodynamic alterations caused by UUO.	Arginine	199-209	endothelin receptor type A	Canis lupus familiaris	92-96
1282968-1	1992	L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing"s syndrome.	Arginine	0-10	alpha hemoglobin stabilizing protein	Homo sapiens	29-64
1282968-1	1992	L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing"s syndrome.	Arginine	0-10	alpha hemoglobin stabilizing protein	Homo sapiens	66-70
12909616-3	2003	Using adult feline cardiomyocytes, here we report that integrin-interacting Arg-Gly-Asp (RGD) peptides activate S6K1 as observed by band shifting, kinase activity and phosphorylation at Thr-389 and Thr-421/Ser-424 of S6K1, and S6 protein phosphorylation.	Arginine	76-79	ribosomal protein S6 kinase B1	Homo sapiens	112-116
1740646-6	1992	Lastly, GM-CSF-derived but not CSF-1-derived BMDMs showed an L-arginine-dependent listeriacidal activity.	Arginine	61-71	colony stimulating factor 2	Homo sapiens	8-14
12909616-3	2003	Using adult feline cardiomyocytes, here we report that integrin-interacting Arg-Gly-Asp (RGD) peptides activate S6K1 as observed by band shifting, kinase activity and phosphorylation at Thr-389 and Thr-421/Ser-424 of S6K1, and S6 protein phosphorylation.	Arginine	76-79	ribosomal protein S6 kinase B1	Homo sapiens	217-221
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Arginine	25-28	cAMP responsive element binding protein 1	Rattus norvegicus	4-9
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Arginine	25-28	cAMP responsive element binding protein 1	Rattus norvegicus	4-8
14511678-5	2003	ACC-CREBp was a variant (Arg to Pro) of ACC-CREB, a hybrid peptide consisting of a 9-amino-acid peptide from rat acetyl-CoA carboxylase (ACC), CREB peptide, and the addition of two hydrophobic Leu residues.	Arginine	25-28	cAMP responsive element binding protein 1	Rattus norvegicus	44-48
14588116-8	2003	These differences in cerebral hemodynamics between the eNOS-deficient and the wild-type mice suggest an important role for nitric oxide produced by eNOS in the preservation of cerebral blood flow in contused brain following traumatic injury, and in the improvement in cerebral blood flow with L-arginine administration.	Arginine	293-303	nitric oxide synthase 3, endothelial cell	Mus musculus	55-59
14588116-8	2003	These differences in cerebral hemodynamics between the eNOS-deficient and the wild-type mice suggest an important role for nitric oxide produced by eNOS in the preservation of cerebral blood flow in contused brain following traumatic injury, and in the improvement in cerebral blood flow with L-arginine administration.	Arginine	293-303	nitric oxide synthase 3, endothelial cell	Mus musculus	148-152
14502486-4	2003	Despite the differences in the structural/dynamics behavior of the two agonists when docked into the 5-HT(1A) receptor, they both exert a destabilization of the intrahelical and interhelical interactions found in the empty and antagonist-bound receptor forms between the arginine of the E/DRY sequence and both D133(3.49) and E340(6.30).	Arginine	271-279	5-hydroxytryptamine receptor 1A	Homo sapiens	101-118
12815280-5	2003	To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized.	Arginine	47-50	LIM domain binding 3a	Danio rerio	37-41
12815280-5	2003	To test this hypothesis, the peptide zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone (zDRHDfmk) was synthesized.	Arginine	47-50	LIM domain binding 3a	Danio rerio	38-41
12895593-6	2003	Site-directed mutagenesis of LTC(4) synthase suggests that Arg-51 is involved in opening the epoxide ring of LTA(4) and Tyr-93 in GSH thiolate anion formation during catalytic conjugation.	Arginine	59-62	leukotriene C4 synthase	Homo sapiens	29-44
12843189-4	2003	Insulin sensitivity, assessed by hyperinsulinemic-euglycemic clamp, was significantly reduced in carriers of Arg(972) IRS-1 (P &lt; 0.03).	Arginine	109-112	insulin receptor substrate 1	Homo sapiens	118-123
12843189-5	2003	Carriers of Arg(972) IRS-1 displayed many features of the insulin resistance syndrome, including higher values for serum triglycerides (P &lt; 0.01), total/high density lipoprotein cholesterol ratio (P &lt; 0.01), free fatty acid levels (P &lt; 0.04), systolic blood pressure (P &lt; 0.04), microalbuminuria (P &lt; 0.003), and intima-media thickness (P &lt; 0.02).	Arginine	12-15	insulin receptor substrate 1	Homo sapiens	21-26
12843189-6	2003	These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities.	Arginine	31-34	insulin receptor substrate 1	Homo sapiens	40-45
12787390-7	2003	RESULTS: DNA sequencing of the apoAII gene in the proband showed a T to C transition at the first position of the stop codon indicating replacement of the stop codon by l-arginine (Arg) at residue 78.	Arginine	169-179	apolipoprotein A2	Homo sapiens	31-37
12787390-7	2003	RESULTS: DNA sequencing of the apoAII gene in the proband showed a T to C transition at the first position of the stop codon indicating replacement of the stop codon by l-arginine (Arg) at residue 78.	Arginine	181-184	apolipoprotein A2	Homo sapiens	31-37
12558503-3	2003	The arginine- and serine-rich domain of U2AF(65) is critical for U1 recruitment, and we discuss the role of its RNA-RNA annealing activity in this novel function of U2AF(65).	Arginine	4-12	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	40-47
12558503-3	2003	The arginine- and serine-rich domain of U2AF(65) is critical for U1 recruitment, and we discuss the role of its RNA-RNA annealing activity in this novel function of U2AF(65).	Arginine	4-12	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	40-48
12473655-8	2003	The mass spectra for the Asp(131)-Arg(153) peptides from the oxidized and reduced forms of human RNase H1 in the presence and absence of NEM showed peptide masses consistent with the formation of a disulfide bond between Cys(147) and Cys(148).	Arginine	34-37	ribonuclease H1	Homo sapiens	97-105
12926399-3	2003	Barrels with internal arginine-histidine dyads form cation selective (PK/Pc1 = 2.1), small and ohmic ion channels with superb stability (single-channel lifetime &gt; 20 seconds).	Arginine	22-30	polycystin 1, transient receptor potential channel interacting	Homo sapiens	73-76
12706102-4	2003	Site-directed mutagenesis of p33 expressed in Escherichia coli, followed by a gel shift assay, defined two of the four arginines as required for efficient RNA binding in vitro.	Arginine	119-128	inhibitor of growth family member 1	Homo sapiens	29-32
12529320-3	2003	To test this hypothesis, we have constructed several mutants of TM456 and protein C in which charges of the putative interacting residues on both TM4 (Asp/Glu) and protein C (Lys/Arg) have been reversed.	Arginine	179-182	thrombomodulin	Homo sapiens	64-69
12510060-5	2003	However, when a second arginine dose was given 10 min after, there was a negligible insulin secretory response in Rab3A(-/-) mice, compared with that in Rab3A(+/+) animals, that was markedly increased above that to the first arginine stimulus.	Arginine	23-31	RAB3A, member RAS oncogene family	Mus musculus	114-119
12510060-5	2003	However, when a second arginine dose was given 10 min after, there was a negligible insulin secretory response in Rab3A(-/-) mice, compared with that in Rab3A(+/+) animals, that was markedly increased above that to the first arginine stimulus.	Arginine	23-31	RAB3A, member RAS oncogene family	Mus musculus	153-158
12556352-2	2003	The insulin response to arginine at fasting (AIR(1)), at 14 mmol/l, and at &gt;25 mmol/l glucose was reduced by 37-50% after 15 and 25% WR (P &lt;or= 0.05).	Arginine	24-32	zinc finger CCHC-type containing 7	Homo sapiens	45-51
12620851-3	2003	A pro3 ure2 strain expressing a PGK1 promoter-driven PUT2 allele encoding Delta(1)-pyrroline-5-carboxylate dehydrogenase lacking a mitochondrial targeting sequence produced significant cytoplasmic activity, accumulated twice as much intracellular glutamate, and produced twice as much cell mass as the parent when grown anaerobically on limiting arginine as sole nitrogen source.	Arginine	346-354	1-pyrroline-5-carboxylate dehydrogenase	Saccharomyces cerevisiae S288C	53-57
12606535-0	2003	The Gly972--&gt;Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.	Arginine	16-19	insulin receptor substrate 1	Homo sapiens	20-25
12634846-4	2003	Deletion of the genes encoding both of these proteins or disruption of two of the arginine/serine repeats each shifts the steady-state localization of Gbp2 to the cytoplasm.	Arginine	82-90	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	151-155
12634850-2	2003	Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been identified in AR-JP patients, the function of this domain is not clear.	Arginine	42-45	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	144-149
12634850-5	2003	Our findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10-binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR-JP.	Arginine	30-33	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	Homo sapiens	85-90
12634850-5	2003	Our findings suggest that the Arg 42 mutation induces a conformational change in the Rpn10-binding site of Ubl, resulting in impaired proteasomal binding of parkin, which could be the cause of AR-JP.	Arginine	30-33	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	193-198
12551840-4	2003	Basal sGC immunoreactivities in vivo to mAb3221 but not to mAb28131 were enhanced by injecting L-arginine and attenuated by blocking NO synthases, suggesting the ability of the former mAb to sense NO.	Arginine	95-105	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	6-9
1662618-19	1991	The results from the MeArg and EDRF inhibitor experiments support the existence of the L-arginine/NO pathway in platelets.	Arginine	87-97	alpha hemoglobin stabilizing protein	Homo sapiens	31-35
1662618-20	1991	In addition, the prevention of spin-adduct formation by EDRF inhibitors, suggests that the mechanisms of EDRF formation and the L-arginine/NO pathway in endothelial cells and platelets are similar.	Arginine	128-138	alpha hemoglobin stabilizing protein	Homo sapiens	56-60
1837236-0	1991	The role of arginine residues in interleukin 1 receptor binding.	Arginine	12-20	interleukin 1 alpha	Homo sapiens	33-46
1837236-4	1991	Modification of the proteins with phenylglyoxal, an arginine-specific reagent, resulted in the loss of Type 1 IL-1 receptor binding activity.	Arginine	52-60	interleukin 1 alpha	Homo sapiens	110-114
1837236-5	1991	The stoichiometry of this modification revealed that a single arginine in either IL-1 alpha or IL-1 beta is responsible for the loss of activity.	Arginine	62-70	interleukin 1 alpha	Homo sapiens	81-91
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 alpha	Homo sapiens	52-62
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	132-140	interleukin 1 alpha	Homo sapiens	147-157
12584360-1	2003	The capsid (CA) domain of the Moloney murine leukemia virus (Mo-MuLV) Gag protein has a unique carboxy terminus with a highly charged arginine-rich sequence.	Arginine	134-142	Pr65	Moloney murine leukemia virus	70-73
1837236-6	1991	Cyanogen bromide cleavage of phenylglyoxal modified IL-1 alpha and IL-1 beta, followed by sequencing of the peptides, revealed that arginine-12 in IL-1 alpha and arginine-4 in IL-1 beta, which occupy the same topology in the respective crystallographic structures, are the target of phenylglyoxal.	Arginine	162-170	interleukin 1 alpha	Homo sapiens	52-62
12546703-8	2003	This is a result of 10-fold higher levels of arginase I in the SHIP(-/-) macrophages, which redirects the iNOS substrate, L-arginine, from NO to ornithine production.	Arginine	122-132	inositol polyphosphate-5-phosphatase D	Mus musculus	63-67
1723393-4	1991	B-cell secretion of IAPP in response to arginine, isobutylmethylxanthine or both together was potentiated by increasing glucose concentrations from 1.67 to 16.7 mM.	Arginine	40-48	islet amyloid polypeptide	Rattus norvegicus	20-24
12631117-2	2003	We have previously shown that VEGF is up-regulated in a model of chronic cyclosporine (CsA) nephrotoxicity and that l-arginine (l-Arg) improved while N-nitro-l-arginine-methyl ester (L-NAME) worsened fibrosis.	Arginine	116-126	vascular endothelial growth factor A	Rattus norvegicus	30-34
1662200-6	1991	These results are consistent with the hypothesis that EDRF production may involve the formation of nitric oxide or a nitroso compound from L-arginine and that EDRF production may have a role in the regulation of tone and in the mediation of responses to acetylcholine and bradykinin in the pulmonary vascular bed of the cat.	Arginine	139-149	alpha hemoglobin stabilizing protein	Homo sapiens	54-58
12631117-7	2003	VEGF mRNA and protein expressions increased with CsA, further increased with L-NAME and became significantly reduced with L-Arg.	Arginine	122-127	vascular endothelial growth factor A	Rattus norvegicus	0-4
12586542-12	2003	The expression of alpha-SMA was lower in L-arginine-treated rats than in untreated rats (1.93+/-0.8% area surface vs 3.64+/-2.5% area surface).	Arginine	41-51	actin gamma 2, smooth muscle	Rattus norvegicus	18-27
1755504-5	1991	Additionally, when the cDNA from P rats was used as reference, a substitution (G for A) was identified in the cDNA of NP rats which changes amino acid 67 from Gln (CAG codon; ALDH2Q allele) to Arg (CGG codon; ALDH2R allele).	Arginine	193-196	aldehyde dehydrogenase 2 family member	Rattus norvegicus	175-180
1755504-5	1991	Additionally, when the cDNA from P rats was used as reference, a substitution (G for A) was identified in the cDNA of NP rats which changes amino acid 67 from Gln (CAG codon; ALDH2Q allele) to Arg (CGG codon; ALDH2R allele).	Arginine	193-196	aldehyde dehydrogenase 2 family member	Rattus norvegicus	209-214
12514069-2	2003	An arginase mutant accumulated higher levels of arginine and/or glutamate and showed increased leavening ability during the frozen-dough baking process, suggesting that disruption of the CAR1 gene enhances freeze tolerance.	Arginine	48-56	arginase	Saccharomyces cerevisiae S288C	187-191
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Arginine	226-229	major prion protein	Ovis aries	47-50
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Arginine	226-229	major prion protein	Ovis aries	130-133
12488533-0	2003	Chemical synthesis of MT1 and MT7 muscarinic toxins: critical role of Arg-34 in their interaction with M1 muscarinic receptor.	Arginine	70-73	metallothionein 1I, pseudogene	Homo sapiens	22-25
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Arginine	255-258	major prion protein	Ovis aries	47-50
1681027-4	1991	By sequencing the protein coding region of the PrP gene in Cheviot sheep selected for differing Sip genotypes, we have found four PrP protein variants which differ at three positions: amino acid 112 (Ala/Val), amino acid 130 (Arg/His) and amino acid 147 (Arg/Gln).	Arginine	255-258	major prion protein	Ovis aries	130-133
12498683-8	2002	A mechanism for the observed cooperation between acetylation and arginine methylation comes from the finding that acetylation at K18 and K23, but not K14, tethers recombinant CARM1 to the H3 tail and allows it to act as a more efficient arginine methyltransferase.	Arginine	65-73	keratin 18	Homo sapiens	129-132
12237300-5	2002	Here we show that HuR can be methylated on arginine.	Arginine	43-51	ELAV like RNA binding protein 1	Homo sapiens	18-21
1656519-4	1991	Allelic variants were isolated at the second locus: a novel clone encoding apoSAA2 alpha was distinguished from SAA2 beta (previously known as SAAg9, Ref.1) by a His/Arg polymorphism at residue 71.SAA1 and SAA2 found in the high density lipoprotein fraction of acute-phase plasma were approximately 90% homologous at the nucleotide level.	Arginine	166-169	serum amyloid A2	Homo sapiens	78-82
1776135-3	1991	Arginine-406 is located at the 12th amino acid residue from the reactive site on the C-terminal side of AT-III in a core region of the molecule which has been highly conserved during evolution of serine protease inhibitor (serpin) family.	Arginine	0-8	serpin family C member 1	Homo sapiens	104-110
1680853-0	1991	Interaction of gamma-glutamyl transpeptidase with glutathione involves specific arginine and lysine residues of the heavy subunit.	Arginine	80-88	gamma-glutamyltransferase 1	Rattus norvegicus	15-44
1716439-7	1991	rMNK1 and mMNK1 differed from a recently reported MAP-2 kinase cDNA, termed ERK1, because of a nonconservative change in position 82, from Gly in ERK1 to Arg in rMNK1.	Arginine	154-157	microtubule-associated protein 2	Rattus norvegicus	50-55
1907850-8	1991	Thus, since FAH2 and MTX interact with the guanidinium side chain of arginine-70 in the wild-type hDHFR, the replacement of this residue with a lysine in the R70K mutant appears to have resulted in the introduction of a titratable group with a perturbed pKa value of ca.	Arginine	69-77	dihydrofolate reductase	Homo sapiens	98-103
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	86-89	serpin family E member 1	Homo sapiens	44-49
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	86-89	serpin family E member 1	Homo sapiens	126-131
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	90-93	serpin family E member 1	Homo sapiens	44-49
1908232-3	1991	Quantitative analyses of the interaction of PAI-1 with the peptide containing the Asn-Arg-Arg-Leu sequence indicated that the PAI-1 binding site residues in the inner loop of the kringle-2 domain and is preferentially expressed in two chain tPA.	Arginine	90-93	serpin family E member 1	Homo sapiens	126-131
1905815-6	1991	Dominant-negative mutants of Rex also bind to the RexRE with high affinity, while a recessive-negative Rex mutant altered within its arginine-rich, positively charged domain fails to engage the RexRE.	Arginine	133-141	p27	Human T-cell leukemia virus type I	50-53
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Arginine	166-174	histidine permease	Saccharomyces cerevisiae S288C	197-201
1903415-0	1991	IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism.	Arginine	97-107	interferon gamma	Rattus norvegicus	0-9
1903415-2	1991	Monomethyl-L-arginine (NGMMLA), the competitive inhibitor of L-arginine as substrate for production of nitric oxides by hepatocytes, reversed the activity of IFN-gamma on these malaria-infected cells.	Arginine	11-21	interferon gamma	Rattus norvegicus	158-167
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	13-23	interferon gamma	Rattus norvegicus	94-103
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	13-23	interferon gamma	Rattus norvegicus	207-216
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	13-23	interferon gamma	Rattus norvegicus	207-216
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	171-181	interferon gamma	Rattus norvegicus	94-103
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	171-181	interferon gamma	Rattus norvegicus	207-216
1903415-4	1991	Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of NGMMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity.	Arginine	171-181	interferon gamma	Rattus norvegicus	207-216
12237300-8	2002	By analyzing methylation of specific HuR arginine-to-lysine mutants and by sequencing radioactively methylated HuR peptides, Arg(217) was identified as the major HuR methylation site.	Arginine	125-128	ELAV like RNA binding protein 1	Homo sapiens	111-114
12237300-8	2002	By analyzing methylation of specific HuR arginine-to-lysine mutants and by sequencing radioactively methylated HuR peptides, Arg(217) was identified as the major HuR methylation site.	Arginine	125-128	ELAV like RNA binding protein 1	Homo sapiens	111-114
12237300-9	2002	Arg(217) is located in the hinge region between the second and third of the three HuR RNA recognition motif domains.	Arginine	0-3	ELAV like RNA binding protein 1	Homo sapiens	82-85
2022663-5	1991	We found 134 unique PAI-1 variants that retained inhibitory activity towards UK; they contained a variety of amino acids in their P3 and P2 positions but only Arg or, infrequently, Lys in their P1 position.	Arginine	159-162	serpin family E member 1	Homo sapiens	20-25
12481980-12	2002	NO and EDRF share similar chemical and pharmacological properties and are derived from the oxidation of a terminal guanidine group of L-Arg.	Arginine	134-139	alpha hemoglobin stabilizing protein	Homo sapiens	7-11
2014246-4	1991	The specificities of these mAbs have been mapped to sequences near the tip of the disulfide loop of the gp120 third variable domain, Lys-Arg-Ile-His-Ile and His-Ile-Gly-Pro-Gly-Arg, respectively.	Arginine	177-180	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	104-109
12196513-7	2002	Transfection of Rap1b mutants S17N (Ser --&gt; Asn) or T61R (Thr --&gt; Arg) in MCs inhibited the HG-induced increased FN synthesis.	Arginine	72-75	fibronectin 1	Rattus norvegicus	119-121
1900240-8	1991	Evidence is presented that the synergistic action of IL 4 and IFN-gamma occurs via an L-arginine-dependent killing pathway.	Arginine	86-96	interleukin 4	Mus musculus	53-57
2039602-7	1991	ODC specific activity, when correlated with growth, was higher in livers of arginine-starved rats than in control animals.	Arginine	76-84	ornithine decarboxylase 1	Rattus norvegicus	0-3
12504227-9	2002	These data suggest that phorbol ester stimulates arginine transport in Caco-2 cells via signaling pathways that lead to increased transcription and/or stabilization of CAT1 mRNA.	Arginine	49-57	GIT ArfGAP 1	Homo sapiens	168-172
12145316-7	2002	Mutational analysis identified five of these residues (Lys-227, Asn-231, Asn-278, Lys-308, and Arg-312) as essential for Hsp90 binding.	Arginine	95-98	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	121-126
1776333-2	1991	This includes the generation of endothelium-derived factors, such as the arachidonic acid metabolite prostacyclin and endothelium-derived relaxing factor (EDRF), probably NO, generated from L-arginine.	Arginine	190-200	alpha hemoglobin stabilizing protein	Homo sapiens	118-153
1776333-2	1991	This includes the generation of endothelium-derived factors, such as the arachidonic acid metabolite prostacyclin and endothelium-derived relaxing factor (EDRF), probably NO, generated from L-arginine.	Arginine	190-200	alpha hemoglobin stabilizing protein	Homo sapiens	155-159
12379114-5	2002	The peptides were also tested for the inhibition of the binding of factor Va to membrane-bound active site fluorescent labeled Glu-Gly-Arg human factor Xa ([OG488]-EGR-hXa).	Arginine	135-138	amylase alpha 2B	Homo sapiens	152-154
2270316-0	1990	Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas.	Arginine	72-80	islet amyloid polypeptide	Rattus norvegicus	25-31
2270316-8	1990	Finally, amylin, at 500 nM, reduced the insulin response to 3.5 mM arginine (ca.	Arginine	67-75	islet amyloid polypeptide	Rattus norvegicus	9-15
2270316-10	1990	It can be concluded that, in the rat pancreas, the inhibitory effect of homologous amylin on unstimulated insulin secretion, as well as on the insulin responses to metabolic substrates (glucose and arginine), favours the concept of this novel peptide as a potential diabetogenic agent.	Arginine	198-206	islet amyloid polypeptide	Rattus norvegicus	83-89
12374746-7	2002	We also provide functional evidence that arginine residues methylated by CARM1 play a critical role in GRIP-1-dependent transcriptional activation and in hormone-induced gene activation.	Arginine	41-49	glutamate receptor interacting protein 1	Homo sapiens	103-109
2261856-0	1990	Amylin release from perfused rat pancreas in response to glucose and arginine.	Arginine	69-77	islet amyloid polypeptide	Rattus norvegicus	0-6
12140285-6	2002	Experiments conducted with two fragments of TP1 containing arginine and lysine residues demonstrated that DNA binding by TP1 must involve more than these basic sequences.	Arginine	59-67	transition protein 1	Homo sapiens	44-47
2261856-1	1990	The effects of glucose and arginine on the release of amylin from the perfused rat pancreas were studied.	Arginine	27-35	islet amyloid polypeptide	Rattus norvegicus	54-60
2261856-4	1990	Additionally, 10 mM arginine in the presence of 5.5 mM glucose also stimulated amylin release.	Arginine	20-28	islet amyloid polypeptide	Rattus norvegicus	79-85
12140285-6	2002	Experiments conducted with two fragments of TP1 containing arginine and lysine residues demonstrated that DNA binding by TP1 must involve more than these basic sequences.	Arginine	59-67	transition protein 1	Homo sapiens	121-124
12381362-8	2002	Mono S chromatography of 2 out of 26 individual human whey samples showed a rare polymorphic hLF variant with three N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Ser(5)-) instead of the usual variant with four N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Arg(5)-Ser(6)-).	Arginine	145-148	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-96
2204806-1	1990	Expression of the arginase (CAR1) gene in Saccharomyces cerevisiae is induced by arginine or its analog homoarginine.	Arginine	81-89	arginase	Saccharomyces cerevisiae S288C	28-32
2168884-1	1990	Two gastrin analogs containing a D- and a L-tetrafluorinated tyrosyl residue (Arg-Arg-Leu-Glu-Glu-Glu-Glu-Glu-Ala-(F4)Tyr-Gly) were synthesized and tested as substrates and inhibitors of the insulin receptor kinase.	Arginine	82-85	gastrin	Homo sapiens	4-11
12381362-8	2002	Mono S chromatography of 2 out of 26 individual human whey samples showed a rare polymorphic hLF variant with three N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Ser(5)-) instead of the usual variant with four N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Arg(5)-Ser(6)-).	Arginine	152-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-96
12381362-8	2002	Mono S chromatography of 2 out of 26 individual human whey samples showed a rare polymorphic hLF variant with three N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Ser(5)-) instead of the usual variant with four N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Arg(5)-Ser(6)-).	Arginine	152-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-96
2148938-1	1990	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-OEt is the analog of the S-site, one of the actin-binding sites in myosin [Suzuki et al.	Arginine	21-24	myosin heavy chain 14	Homo sapiens	112-118
12381362-8	2002	Mono S chromatography of 2 out of 26 individual human whey samples showed a rare polymorphic hLF variant with three N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Ser(5)-) instead of the usual variant with four N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Arg(5)-Ser(6)-).	Arginine	152-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-96
2148938-1	1990	The heptapeptide Ile-Arg-Ile-Cys-Arg-Lys-Gly-OEt is the analog of the S-site, one of the actin-binding sites in myosin [Suzuki et al.	Arginine	33-36	myosin heavy chain 14	Homo sapiens	112-118
12381362-8	2002	Mono S chromatography of 2 out of 26 individual human whey samples showed a rare polymorphic hLF variant with three N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Ser(5)-) instead of the usual variant with four N-terminal arginines (Gly(1)-Arg(2)-Arg(3)-Arg(4)-Arg(5)-Ser(6)-).	Arginine	152-155	HLF transcription factor, PAR bZIP family member	Homo sapiens	93-96
2148938-10	1990	Based on these results, the side chains of Ile(702), Arg(703), and Cys(SH1)(705) in myosin subfragment-1 heavy chain were assigned to be critical for the binding with F-actin.	Arginine	53-56	myosin heavy chain 14	Homo sapiens	84-90
12374781-7	2002	Genistein (10 microM) and PD98059 (10 microM), an inhibitor of MAPK kinase 1/2 (MEK1/2), inhibited adenosine-stimulated l-arginine transport, NO production, and phosphorylation of p42/p44MAPK.	Arginine	120-130	mitogen-activated protein kinase kinase 1	Homo sapiens	80-86
12234302-8	2002	On the other hand, PAF inhibited both the basal and l-arginine induced synthesis of NO by mesangial cells.	Arginine	52-62	PCNA clamp associated factor	Homo sapiens	19-22
2255125-13	1990	L-NMMA is a known inhibitor of synthesis of "classical" EDRF from L-arginine.	Arginine	66-76	alpha hemoglobin stabilizing protein	Mus musculus	56-60
12237402-3	2002	One day after intratracheal administration of AdCMVeNOS to eNOS(-/-) mice, there was an increase in eNOS protein, cGMP levels, and calcium-dependent conversion of l-arginine to l-citrulline in the lung.	Arginine	163-173	nitric oxide synthase 3, endothelial cell	Mus musculus	51-55
2235124-1	1990	Circulating arginine available for synthesis of protein is produced in the kidney of the adult mammal by the action of the last two enzymes of the urea cycle, argininosuccinate synthase and argininosuccinate lyase.	Arginine	12-20	argininosuccinate synthase 1	Homo sapiens	159-185
12403465-3	2002	A class of peptidomimetics [aminoglycoside-arginine conjugates (AAC)] has recently been designed to inhibit HIV TAR/tat interaction and in experiments aimed at assessing the inhibitory effects of AACs on TAR-containing transcripts, we found that AACs are general inhibitors of translation.	Arginine	43-51	acetoacetyl-CoA synthetase	Homo sapiens	196-200
2164357-2	1990	EPR signals of Mn(II) in the GDP complex with viral-Harvey p21pRAS1 (Arg 12, Thr 59), p21EC (Gly 12, Thr 59), and p21EJ (Val 12, Thr 59) have narrow line-widths that permit ready observation of inhomogeneous broadening from unresolved superhyperfine coupling with the nuclear spin of 17O of directly coordinated oxygen ligands.	Arginine	69-72	H3 histone pseudogene 16	Homo sapiens	59-67
12403465-3	2002	A class of peptidomimetics [aminoglycoside-arginine conjugates (AAC)] has recently been designed to inhibit HIV TAR/tat interaction and in experiments aimed at assessing the inhibitory effects of AACs on TAR-containing transcripts, we found that AACs are general inhibitors of translation.	Arginine	43-51	acetoacetyl-CoA synthetase	Homo sapiens	246-250
12403465-6	2002	Structure/activity relationship studies suggest that inhibition of translation by AACs is directly related to the number of arginine groups present on the aminoglycoside backbone and to the nature of the core aminoglycoside.	Arginine	124-132	acetoacetyl-CoA synthetase	Homo sapiens	82-86
1973165-0	1990	Site-directed mutagenesis of arginine 246, glutamic acid 247, and histidine 248 in the eukaryotic transcription factor S-II.	Arginine	29-37	transcription elongation factor A1	Homo sapiens	119-123
12171910-2	2002	Here we show that arginine methylation of STAT1 controls the rate of STAT1 dephosphorylation by modulating its interaction with PIAS1 and the nuclear tyrosine phosphatase TcPTP.	Arginine	18-26	protein inhibitor of activated STAT 1	Homo sapiens	128-133
1972730-4	1990	CD2 M1 (271-272), CD2 M2 (278-279), and CD2 M4 (264-265) mutants replaced the positively charged adjacent aa histidine and arginine (HR) in the wild-type CD2 sequence with aspartic and glutamic acid (DE) at positions 271-272, 278-279, and 264-265, respectively.	Arginine	123-131	CD2 molecule	Homo sapiens	0-3
1972730-8	1990	Thus, alteration of histidine 264 and/or arginine 265 within the first PPPGHR motif affects the process of signal transduction via CD2, whereas identical mutations in residues at 271-272 or 278-279 were individually without effect.	Arginine	41-49	CD2 molecule	Homo sapiens	131-134
12171910-5	2002	Furthermore, inhibitors of arginine methylation require the presence of PIAS1 to exert their negative regulatory effect on the dephosphorylation of STAT1.	Arginine	27-35	protein inhibitor of activated STAT 1	Homo sapiens	72-77
12270147-7	2002	The effect of leptin on the membrane fluidity was significantly potentiated by the nitric oxide (NO) donors, L-arginine and S-nitroso-N-acetylpenicillamine (SNAP), and a cyclic guanosine monophosphate (cGMP) analog, 8-bromo-cGMP.	Arginine	109-119	leptin	Homo sapiens	14-20
12218175-6	2002	Unlike FKBP-FK506, CyPA-CsA interacts with Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN catalysis.	Arginine	43-46	peptidylprolyl isomerase A	Homo sapiens	19-23
12218175-6	2002	Unlike FKBP-FK506, CyPA-CsA interacts with Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN catalysis.	Arginine	43-46	peptidylprolyl isomerase A	Homo sapiens	108-112
1698194-1	1990	We have investigated the anti-angiogenic effect of a polymeric peptide based on the Arg-Gly-Asp (RGD) core sequence of fibronectin as a monomer unit, i.e., poly(RGD), in syngeneic mice and in vitro.	Arginine	84-87	fibronectin 1	Mus musculus	119-130
12093802-7	2002	These effects as well as the ability of full-length p13(II) to alter mitochondrial morphology in cells required the presence of four arginines, forming the charged face of the targeting signal.	Arginine	133-142	H3 histone pseudogene 6	Homo sapiens	52-55
2119367-1	1990	We have investigated the anti-metastatic and anti-invasive activities of polypeptide analogues based on the Arg-Gly-Asp (RGD) adhesive signal in fibronectin, poly(RGD), poly(RGDS)[Arg-Gly-Asp-Ser] and poly(RGDT)[Arg-Gly-Asp-Thr].	Arginine	108-111	fibronectin 1	Mus musculus	145-156
12082117-9	2002	Like other GAPs, Kir3.4 contains a tyrosine-arginine-glutamine motif that is thought to function by interacting with G protein catalytic domains to facilitate GTP hydrolysis.	Arginine	44-52	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	17-23
2135403-7	1990	Furthermore, both arginine, a cleavage product of BK by carboxypeptidase B, and arachidonic acid, which were endogenous activators for soluble guanylate cyclase, enhanced the BANA-degrading activity in the pulp homogenate.	Arginine	18-26	carboxypeptidase B1	Rattus norvegicus	56-74
12385583-10	2002	In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively.	Arginine	206-209	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
2334429-3	1990	This mutation results in an amino-acid replacement of a conserved arginine by histidine at the residue "173," which is involved in an anion-binding site at the P-axis of LDH subunits.	Arginine	66-74	lactate dehydrogenase B	Homo sapiens	170-173
12068020-2	2002	The epitope for thrombomodulin binding is shaped as a hot spot in exosite I, centered around the buried ion quartet formed by Arg(67), Lys(70), Glu(77), and Glu(80), and capped by the hydrophobic residues Tyr(76) and Ile(82).	Arginine	126-129	thrombomodulin	Homo sapiens	16-30
2307082-3	1990	At 12-24 hr after the arginine injection, serum levels of amylase, lipase, and anionic trypsin(ogen) reached respective peak values 2, 5, and 20 times those of control rats without arginine and returned to control levels after 24-48 hr.	Arginine	22-30	lipase G, endothelial type	Rattus norvegicus	67-73
12065763-6	2002	Substituting this histidine with arginine not only accelerated the time course of macroscopic channel inactivation but also eliminated the H+ effects on hKv1.4.	Arginine	33-41	potassium voltage-gated channel subfamily A member 4	Homo sapiens	153-159
2155150-4	1990	Production of the EDRF-like factor was dependent on L-arginine and NADPH.	Arginine	52-62	alpha hemoglobin stabilizing protein	Mus musculus	18-22
2155150-6	1990	The production of the EDRF-like activity was inhibited by the L-arginine analogs, NG-monomethyl-L-arginine and NG-nitro-L-arginine, with apparent Ki values of 1.0 and 0.3 microM, respectively.	Arginine	62-72	alpha hemoglobin stabilizing protein	Mus musculus	22-26
12152665-0	2002	Low arginine intake reduces levels of soluble P-selectin in hypercholesterolemic patients.	Arginine	4-12	selectin P	Homo sapiens	46-56
2406564-0	1990	Arginine-specific repression in Saccharomyces cerevisiae: kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism.	Arginine	0-8	argininosuccinate synthase	Saccharomyces cerevisiae S288C	74-78
2406564-0	1990	Arginine-specific repression in Saccharomyces cerevisiae: kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism.	Arginine	0-8	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	83-87
2406564-8	1990	A similar analysis of expression of the gene CPA1, for which a translational regulation by arginine has been clearly demonstrated (M. Werner, A. Feller, F. Messenguy, and A. Pierard, Cell 49:805-813, 1987), indicates that this gene is also partly regulated at the transcriptional level by the ARGR repressor system.	Arginine	91-99	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	45-49
12161073-4	2002	Two other residues, Lys 114 and Arg 129, then cooperate with Lys 125 to induce the low-affinity complex into an activated, high-affinity complex, in which a network of electrostatic interactions between antithrombin and the entire pentasaccharide is established.	Arginine	32-35	serpin family C member 1	Homo sapiens	203-215
2406564-9	1990	Moreover, the half-life of CPA1 mRNA is reduced twofold in the presence of excess arginine; we suggest that this could be inherent in the mechanism of translational regulation of CPA1.	Arginine	82-90	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	27-31
2406564-9	1990	Moreover, the half-life of CPA1 mRNA is reduced twofold in the presence of excess arginine; we suggest that this could be inherent in the mechanism of translational regulation of CPA1.	Arginine	82-90	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	179-183
11967263-7	2002	We have shown that the Arg(96) mutant does not induce beta-catenin degradation but instead stabilizes beta-catenin, indicating that it is unable to phosphorylate beta-catenin in intact cells.	Arginine	23-26	catenin beta 1	Homo sapiens	102-114
11967263-7	2002	We have shown that the Arg(96) mutant does not induce beta-catenin degradation but instead stabilizes beta-catenin, indicating that it is unable to phosphorylate beta-catenin in intact cells.	Arginine	23-26	catenin beta 1	Homo sapiens	102-114
2119573-3	1990	The arginase activity of mLIP was identified by determining the arginine degradation products, urea (by alpha-diketone-urea complex formation) and ornithine (by HPLC).	Arginine	64-72	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	25-29
2119573-4	1990	The inhibitory activity of mLIP was neutralized by adding more arginine to the culture medium.	Arginine	63-71	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	27-31
2119573-5	1990	The mutual action between mLIP and arginine was found to be dose-related.	Arginine	35-43	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	26-30
11967263-11	2002	In conclusion, we have found that the Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and that targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45).	Arginine	38-41	catenin beta 1	Homo sapiens	126-138
11967263-11	2002	In conclusion, we have found that the Arg(96) mutant has a dominant-negative effect on GSK-3beta-dependent phosphorylation of beta-catenin and that targeting of beta-catenin for degradation requires prior priming through phosphorylation of Ser(45).	Arginine	38-41	catenin beta 1	Homo sapiens	161-173
12080468-6	2002	It is also shown that multiple signaling molecules, including PI3K, SHC, ras-GAP and CRK-L, are tyrosine phosphorylated in Ba/F3 cells that express ETV6/ARG.	Arginine	153-156	v-crk avian sarcoma virus CT10 oncogene homolog-like	Mus musculus	85-90
12049647-9	2002	The cDNA sequence complements an argA (NAGS)-deficient Escherichia coli strain, reversing its arginine auxotrophy.	Arginine	94-102	N-acetylglutamate synthase	Mus musculus	39-43
7579175-7	1995	The coding region of the genomic sequence, AVA-P3, was interrupted by two introns located at the codons for Cys-26 and Arg-121.	Arginine	119-122	vacuolar-type H[+]-ATPase C3	Arabidopsis thaliana	43-49
12049647-12	2002	The addition of l-arginine increased the catalytic activity of the purified recombinant NAGS enzymes by approx.	Arginine	16-26	N-acetylglutamate synthase	Mus musculus	88-92
12023936-0	2002	Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.	Arginine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	51-57
34749089-4	2022	The color of the meat and myoglobin forms present in the samples were mainly affected by pH differences, caused by a HEPES buffer or arginine.	Arginine	133-141	myoglobin	Homo sapiens	26-35
12036529-3	2002	BACKGROUND: The serine (Ser)-128-arginine (Arg) gene polymorphism of E-selectin has been implicated in the pathogenesis of coronary artery disease (CAD).	Arginine	33-41	selectin E	Homo sapiens	69-79
34561803-4	2022	NO precursor L-arginine and NO synthase inhibitors were found to differentially modulate stress-induced mechanism in altering NF-kappaB, HSP-70, and corticosterone levels.	Arginine	13-23	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	137-143
12036529-3	2002	BACKGROUND: The serine (Ser)-128-arginine (Arg) gene polymorphism of E-selectin has been implicated in the pathogenesis of coronary artery disease (CAD).	Arginine	43-46	selectin E	Homo sapiens	69-79
12134953-1	2002	PURPOSE: To demonstrate that rat alveolar macrophages (AM) exhibited the PepT1-like transporter for the uptake of arginine (Arg)-containing small peptides and utilized these peptides as direct substrates for nitric oxide (NO) production.	Arginine	114-122	solute carrier family 15 member 1	Rattus norvegicus	73-78
12134953-1	2002	PURPOSE: To demonstrate that rat alveolar macrophages (AM) exhibited the PepT1-like transporter for the uptake of arginine (Arg)-containing small peptides and utilized these peptides as direct substrates for nitric oxide (NO) production.	Arginine	124-127	solute carrier family 15 member 1	Rattus norvegicus	73-78
12134953-9	2002	The uptake of Arg-Lys*, beta-Ala-Lys*, and Gly-Sar-Lys* was blocked (approximately 50%) by cephradine (an inhibitor of PepT1 for peptide transport) but not by Lys (an inhibitor on cationic amino acid transporter 2B for Arg transport).	Arginine	14-17	solute carrier family 15 member 1	Rattus norvegicus	119-124
12134953-10	2002	The NO production by AM through Arg-containing peptides was significantly blocked only by PepT1 inhibitors and by an anti-PepT1 antibody in a dose-dependent manner.	Arginine	32-35	solute carrier family 15 member 1	Rattus norvegicus	90-95
12134953-10	2002	The NO production by AM through Arg-containing peptides was significantly blocked only by PepT1 inhibitors and by an anti-PepT1 antibody in a dose-dependent manner.	Arginine	32-35	solute carrier family 15 member 1	Rattus norvegicus	122-127
12134953-17	2002	Arginine-containing peptides, through the PepT1 transporter system, can serve as direct substrates of iNOS for the production of NO by AM.	Arginine	0-8	solute carrier family 15 member 1	Rattus norvegicus	42-47
11864984-5	2002	Mutation of Arg(665), but not the other five residues, prevented hyperpolarization-dependent reopening of D540K HERG channels.	Arginine	12-15	potassium voltage-gated channel subfamily H member 2	Homo sapiens	112-116
11864984-8	2002	Together these findings suggest that a single residue (Arg(665)) in the S6 domain interacts with Lys(540) by electrostatic repulsion to couple voltage sensing to hyperpolarization-dependent opening of D540K HERG K(+) channels.	Arginine	55-58	potassium voltage-gated channel subfamily H member 2	Homo sapiens	207-211
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	31-34	melanin concentrating hormone receptor 1	Homo sapiens	178-185
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	31-34	melanin concentrating hormone receptor 2	Homo sapiens	190-197
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	78-81	melanin concentrating hormone receptor 1	Homo sapiens	178-185
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	78-81	melanin concentrating hormone receptor 2	Homo sapiens	190-197
11978638-0	2002	Insulin secretory function is impaired in isolated human islets carrying the Gly(972)--&gt;Arg IRS-1 polymorphism.	Arginine	91-94	insulin receptor substrate 1	Homo sapiens	95-100
11978638-3	2002	Recently, the common Gly(972)--&gt;Arg amino acid polymorphism of insulin receptor substrate 1 (Arg(972) IRS-1) has been associated with human type 2 diabetes.	Arginine	35-38	insulin receptor substrate 1	Homo sapiens	66-94
11978638-3	2002	Recently, the common Gly(972)--&gt;Arg amino acid polymorphism of insulin receptor substrate 1 (Arg(972) IRS-1) has been associated with human type 2 diabetes.	Arginine	35-38	insulin receptor substrate 1	Homo sapiens	105-110
11978638-3	2002	Recently, the common Gly(972)--&gt;Arg amino acid polymorphism of insulin receptor substrate 1 (Arg(972) IRS-1) has been associated with human type 2 diabetes.	Arginine	96-99	insulin receptor substrate 1	Homo sapiens	66-94
11978638-3	2002	Recently, the common Gly(972)--&gt;Arg amino acid polymorphism of insulin receptor substrate 1 (Arg(972) IRS-1) has been associated with human type 2 diabetes.	Arginine	96-99	insulin receptor substrate 1	Homo sapiens	105-110
11978638-4	2002	In this study, we report on some functional and morphological properties of isolated human islets carrying the Arg(972) IRS-1 polymorphism.	Arginine	111-114	insulin receptor substrate 1	Homo sapiens	120-125
11978638-7	2002	Proinsulin release mirrored insulin secretion, and the insulin-to-proinsulin ratio in response to arginine was significantly lower from Arg(972) IRS-1 islets than from control islets.	Arginine	98-106	insulin receptor substrate 1	Homo sapiens	145-150
11978638-7	2002	Proinsulin release mirrored insulin secretion, and the insulin-to-proinsulin ratio in response to arginine was significantly lower from Arg(972) IRS-1 islets than from control islets.	Arginine	136-139	insulin receptor substrate 1	Homo sapiens	145-150
11978638-9	2002	Electron microscopy showed that Arg(972) IRS-1 beta-cells had a severalfold greater number of immature secretory granules and a lower number of mature granules than control beta-cells.	Arginine	32-35	insulin receptor substrate 1	Homo sapiens	41-46
11978638-10	2002	In conclusion, Arg(972) IRS-1 islets have reduced insulin content, impaired insulin secretion, and a lower amount of mature secretory granules.	Arginine	15-18	insulin receptor substrate 1	Homo sapiens	24-29
11978638-11	2002	These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)--&gt;Arg amino acid polymorphism of IRS-1.	Arginine	124-127	insulin receptor substrate 1	Homo sapiens	155-160
11922288-7	2002	The performance of the system was demonstrated in the separation and determination of FITC-labeled arginine, glycine, phenylalanine, and glutamic acid with LIF detection, by continuously introducing a train of different samples through the system without electrical interruption.	Arginine	99-107	LIF interleukin 6 family cytokine	Homo sapiens	156-159
11875045-4	2002	We recently mapped an autosomal semi-dominant cataract [lens opacity 10 (Lop10)] mutation to mouse chromosome 3 and identified a missense mutation (G--&gt;C) in the Gja8 gene, which causes glycine at codon 22 to be replaced with arginine (G22R).	Arginine	229-237	gap junction protein, alpha 8	Mus musculus	165-169
11855982-1	2002	The extracellular loop 3 (ECL3) of the mammalian gonadotropin-releasing hormone receptor (GnRH-R) contains an acidic amino acid (Glu(301) in the mouse GnRH-R) that confers agonist selectivity for Arg(8) in mammalian GnRH.	Arginine	196-199	gonadotropin releasing hormone receptor	Mus musculus	151-157
11940330-8	2002	More specifically, L-arg significantly increased the interstitial immunostaining for collagen III, IV, and fibronectin (P &lt; 0.05, 0.01, respectively), which were positively correlated with the increased expression of alpha-SMA (P &lt; 0.001, respectively).	Arginine	19-24	fibronectin 1	Rattus norvegicus	107-118
11815470-4	2002	We also showed that normal glucose-tolerant carriers of the Gly972Arg polymorphism in the insulin receptor substrate 1 have significantly reduced insulin secretion in response to glucose and arginine but not to GLP-1.	Arginine	191-199	insulin receptor substrate 1	Homo sapiens	90-118
11849379-12	2002	The results of an in vivo mouse assay revealed that L-NAME inhibited the expression of Epo, but this inhibition of Epo expression by L-NAME was rescued by pretreatment with L-arginine.	Arginine	173-183	erythropoietin	Mus musculus	87-90
11849379-12	2002	The results of an in vivo mouse assay revealed that L-NAME inhibited the expression of Epo, but this inhibition of Epo expression by L-NAME was rescued by pretreatment with L-arginine.	Arginine	173-183	erythropoietin	Mus musculus	115-118
11786529-9	2002	These results indicate that a positively charged arginine or lysine residue at position 1232 in the double mutant is required for the proper transport and functional expression of the hNa(v)1.5 protein.	Arginine	49-57	immunoglobulin lambda variable 2-18	Homo sapiens	184-193
11739736-4	2002	Second, U2AF(35) is thought to play a role in the recruitment of U2AF(65) by serine-arginine-rich (SR) proteins in enhancer-dependent splicing.	Arginine	84-92	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	8-16
11739736-4	2002	Second, U2AF(35) is thought to play a role in the recruitment of U2AF(65) by serine-arginine-rich (SR) proteins in enhancer-dependent splicing.	Arginine	84-92	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	65-72
11739736-5	2002	It has been proposed that the physical interaction between the arginine-serine-rich (RS) domain of U2AF(35) and SR proteins is important for this activity.	Arginine	63-71	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	99-106
11705945-0	2001	Arginine-143 of Yersinia enterocolitica YopP crucially determines isotype-related NF-kappaB suppression and apoptosis induction in macrophages.	Arginine	0-8	yopP	Yersinia enterocolitica	40-44
11705945-10	2001	Functional characterization of the resulting mutants revealed a major role of the arginine-143 residue in determining the inhibitory impact of YopP on IKKbeta activity and survival of macrophages.	Arginine	82-90	yopP	Yersinia enterocolitica	143-147
11723235-2	2001	The Glu(7.32(301)) residue, which determines selectivity of the mouse GnRH receptor for Arg(8)-containing GnRH, is Asp(7.32(302)) in the human GnRH receptor.	Arginine	88-91	gonadotropin releasing hormone receptor	Mus musculus	70-83
11708926-4	2001	Inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (SGF) relative to 1, allowing for the incorporation of lipophilic P1" side chains which had the effect of retaining potent TACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall selectivity against MMP1, MMP3, and MMP9.	Arginine	28-36	matrix metallopeptidase 1	Rattus norvegicus	307-311
11708926-4	2001	Inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (SGF) relative to 1, allowing for the incorporation of lipophilic P1" side chains which had the effect of retaining potent TACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall selectivity against MMP1, MMP3, and MMP9.	Arginine	28-36	matrix metallopeptidase 1	Rattus norvegicus	357-361
11720283-0	2001	Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B" and the Sm-like protein LSm4, and their interaction with the SMN protein.	Arginine	29-37	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	103-107
34919920-5	2022	Structural analysis coupled with mutagenesis studies indicated that, in addition to the conserved arginine fingers contributing to the DNA binding specificity, the residues located in the loop1 and alpha1 are also essential for the methylated DNA binding of these MBDs in Arabidopsis thaliana, which explains why AtMBD5 MBD and the other AtMBDs display very weak or no binding to methylated DNA.	Arginine	98-106	methyl-CPG-binding domain protein 5	Arabidopsis thaliana	313-319
11570875-4	2001	Blocking of PAI-1 reactive loop-beta-sheet A interactions through mutation of the P14 Thr --&gt; Arg or annealing a reactive center loop peptide into sheet A did not weaken the binding of the inactive enzymes, suggesting that loop-sheet interactions were unlikely to be induced by the binding.	Arginine	97-100	serpin family E member 1	Homo sapiens	12-17
11686318-1	2001	A heterozygous G-->T transversion at position 1388 of the protein C (PC) gene which predicted the substitution of Arg(-1) to a Leu (PC(R-1L)) was identified in a thrombophilic patient.	Arginine	114-117	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	58-67
34840084-5	2022	As a result, GO@MPDA@Arg composites exhibited excellent enrichment performance for glycopeptides, containing good selectivity (IgG digests : BSA digests = 1:50, molar ratio), low detection limit for IgG digests (10 fmol muL-1), high loading capacity for IgG digests (200 mug mg-1), and good size exclusion (IgG digests : IgG : BSA = 1:100:100, mass ratio).	Arginine	21-24	mitochondrial ubiquitin ligase activator of NFKB 1	Mus musculus	220-225
34932262-2	2022	Here we report selectivity-focused structural modifications of previously reported dihydropyridine lactam 6 by changing linker length and linker type of the lactam side chain in efforts to engage the unique arginine 54 (R54) residue in BRDT-BD1 to achieve BRDT-selective affinity.	Arginine	207-215	bromodomain testis associated	Homo sapiens	256-260
34957557-5	2021	To investigate the role of Sirtuin 1 (Sirt1) and autophagy in L-arg resistance to cementoblast apoptosis and root absorption, resveratrol and EX527 were used to activate or inhibit Sirt1, and chloroquine (CQ) was used to inhibit autophagy.	Arginine	62-67	sirtuin 1	Mus musculus	38-43
34957557-7	2021	Further, L-arg increased Sirt1 expression while Sirt1 suppression by EX527 reversed the inhibitory effect of L-arg on cell apoptosis.	Arginine	9-14	sirtuin 1	Mus musculus	25-30
34957557-7	2021	Further, L-arg increased Sirt1 expression while Sirt1 suppression by EX527 reversed the inhibitory effect of L-arg on cell apoptosis.	Arginine	109-114	sirtuin 1	Mus musculus	25-30
34957557-7	2021	Further, L-arg increased Sirt1 expression while Sirt1 suppression by EX527 reversed the inhibitory effect of L-arg on cell apoptosis.	Arginine	109-114	sirtuin 1	Mus musculus	48-53
34874169-6	2021	Molecular docking and amino acid composition analysis results showed that the high content of C-terminal Arg residues in the peptides could be the essential reason for their alpha-glucosidase inhibition activity.	Arginine	105-108	sucrase-isomaltase	Homo sapiens	174-191
34898206-7	2021	Molecular docking further indicated that a hydrogen bond was generated between OH at the C-3 position of 4,4-dimethylsterols and the alpha-glucosidase residue Arg-442.	Arginine	159-162	sucrase-isomaltase	Homo sapiens	133-150
34520958-1	2021	Peptidylarginine deaminase 4 (PAD4) is a crucial post-translational modifying enzyme catalyzing the conversion of arginine into citrulline residues, and mediating the formation of neutrophil extracellular traps (NETs).	Arginine	114-122	peptidyl arginine deiminase 4	Homo sapiens	0-28
34520958-1	2021	Peptidylarginine deaminase 4 (PAD4) is a crucial post-translational modifying enzyme catalyzing the conversion of arginine into citrulline residues, and mediating the formation of neutrophil extracellular traps (NETs).	Arginine	114-122	peptidyl arginine deiminase 4	Homo sapiens	30-34
34883511-8	2022	Dog platelets, which contain a conserved CatG PAR4 Ser-Arg cleavage site, aggregated in response to human CatG and RALLLGWVPTR, while mouse (Ser-Gln) and rat (Ser-Glu) platelets, were unresponsive.	Arginine	55-58	cathepsin G	Homo sapiens	41-45
34883511-8	2022	Dog platelets, which contain a conserved CatG PAR4 Ser-Arg cleavage site, aggregated in response to human CatG and RALLLGWVPTR, while mouse (Ser-Gln) and rat (Ser-Glu) platelets, were unresponsive.	Arginine	55-58	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	46-50
34883511-8	2022	Dog platelets, which contain a conserved CatG PAR4 Ser-Arg cleavage site, aggregated in response to human CatG and RALLLGWVPTR, while mouse (Ser-Gln) and rat (Ser-Glu) platelets, were unresponsive.	Arginine	55-58	cathepsin G	Homo sapiens	106-110
34943060-10	2021	Our findings revealed that l-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.	Arginine	27-32	sirtuin 1	Mus musculus	136-141
34900520-13	2021	When coexpressing miR-21-5p mimic and CPEB3 in the cells, the protective effects of miR-21-5p under H/R were reversed (all P < 0.05), and the activation of the EGFR/PI3K/AKT pathway was also inhibited (all P < 0.05).	Arginine	102-103	microRNA 215	Mus musculus	18-27
34900520-13	2021	When coexpressing miR-21-5p mimic and CPEB3 in the cells, the protective effects of miR-21-5p under H/R were reversed (all P < 0.05), and the activation of the EGFR/PI3K/AKT pathway was also inhibited (all P < 0.05).	Arginine	102-103	microRNA 215	Mus musculus	84-93
34900520-14	2021	Conclusion: This study showed that miR-21-5p may regulate the EGFR/PI3K/AKT signaling pathway by targeting CPEB3 to reduce H/R-induced cell damage and apoptosis.	Arginine	125-126	microRNA 215	Mus musculus	35-44
34900520-14	2021	Conclusion: This study showed that miR-21-5p may regulate the EGFR/PI3K/AKT signaling pathway by targeting CPEB3 to reduce H/R-induced cell damage and apoptosis.	Arginine	125-126	epidermal growth factor receptor	Mus musculus	62-66
34632723-4	2021	This nanotheranostic system not only exhausts the glucose nutrients in tumor region by the GOx-triggered glucose oxidation, the generated H2 O2 can oxidize L-Arg into NO under acidic tumor microenvironment for enhanced gas therapy.	Arginine	156-161	hydroxyacid oxidase 1, liver	Mus musculus	91-94
34632723-5	2021	As such, there are significant enhancement effects of starvation therapy and gas therapy through the cascade reactions of GOx and L-Arg, which yields a remarkable synergistic therapeutic effect for 4T1 tumor-bearing mice without discernible toxic side effects.	Arginine	130-135	hydroxyacid oxidase 1, liver	Mus musculus	122-125
34738040-6	2021	Similarly, the toll-like receptor (TLR)-4, MyD88, TGFbeta, and p-c-Jun N-terminal kinase (JNK) protein levels in the fetal liver were reduced (P < 0.05) in the NCG and RP-Arg -supplemented groups compared to the RES group.	Arginine	171-174	toll like receptor 4	Homo sapiens	15-41
34738040-7	2021	These results showed that dietary supplementation of RP-Arg or NCG to underfed pregnant ewes could protect against IUGR fetal hepatic inflammation via improving lipid metabolism, down-regulating the TLR-4 and the inflammatory JNK and NF-kappaB signaling pathways, and decreasing cytokine production in ovine fetal blood and liver tissue.	Arginine	56-59	toll like receptor 4	Homo sapiens	199-204
34738042-5	2021	Compared with the control (0.4 mmol/L arginine), 1.2 mmol/L arginine upregulated the relative mRNA expression levels of myogenin (MyoG) and Myomaker at d 2 during myogenic induction (P < 0.05).	Arginine	38-46	myogenin	Mus musculus	130-134
34738042-5	2021	Compared with the control (0.4 mmol/L arginine), 1.2 mmol/L arginine upregulated the relative mRNA expression levels of myogenin (MyoG) and Myomaker at d 2 during myogenic induction (P < 0.05).	Arginine	60-68	myogenin	Mus musculus	130-134
34465228-11	2021	In contrast, the levels of adenosine receptor A3 were increased after MI/R postconditioning compared with the sham group, and its expression continued to increase with the increase of SFI.	Arginine	73-74	adenosine A3 receptor	Rattus norvegicus	27-48
34789879-2	2021	In yeast, Ubr1-a single-subunit E3 ligase-is responsible for the Arg/N-degron pathway2.	Arginine	65-68	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	10-14
34867480-5	2021	The results show that hypoxia upregulates Arg-II expression in HK2 cells, which is inhibited by silencing both hypoxia-inducible factors (HIFs) HIF1alpha and HIF2alpha.	Arginine	42-45	hypoxia inducible factor 1, alpha subunit	Mus musculus	144-153
34867480-5	2021	The results show that hypoxia upregulates Arg-II expression in HK2 cells, which is inhibited by silencing both hypoxia-inducible factors (HIFs) HIF1alpha and HIF2alpha.	Arginine	42-45	endothelial PAS domain protein 1	Mus musculus	158-167
34382363-3	2021	Here, a multistage cooperative nanodrug is developed by the direct self-assembly of cis-platinum (CDDP, Pt), l-arginine (l-Arg, R), and CPG (defined as PtR/CPG) for antitumor chemoimmunotherapy.	Arginine	109-119	patched domain containing 3 (gene/pseudogene)	Homo sapiens	152-155
34403762-8	2021	Through MI/R in vivo, cardiac overexpression of SIRT1 led to ameliorated cardiac function and infarct size, as well as the decreased cardiac oxidative stress.	Arginine	11-12	sirtuin 1	Mus musculus	48-53
34605437-1	2021	The Ca2+-dependent enzyme peptidyl-arginine deiminase type III (PAD3) catalyses the deimination of arginine residues to form citrulline residues in proteins such as keratin, filaggrin and trichohyalin.	Arginine	99-107	filaggrin	Homo sapiens	174-183
34078530-0	2021	Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca2+-dependent eNOS activation.	Arginine	45-55	nitric oxide synthase 3, endothelial cell	Mus musculus	105-109
34078530-8	2021	Treatment of L-Arg and ABH, arginase inhibitor, increased intracellular Ca2+ concentrations and activated CaMKII-dependent eNOS activation in ECs of WT mice, but, the effects were not observed in ECs of inositol triphosphate receptor type 1 knockout (IP3R1-/-) mice.	Arginine	13-18	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	106-112
34078530-8	2021	Treatment of L-Arg and ABH, arginase inhibitor, increased intracellular Ca2+ concentrations and activated CaMKII-dependent eNOS activation in ECs of WT mice, but, the effects were not observed in ECs of inositol triphosphate receptor type 1 knockout (IP3R1-/-) mice.	Arginine	13-18	nitric oxide synthase 3, endothelial cell	Mus musculus	123-127
34697388-6	2021	Arginine-mediated methylation of DDX5 is required for its interaction with Thrap3, and the Thrap3-DDX5 axis induces the recruitment of 5"-3" exoribonuclease 2 (XRN2) into R-loops.	Arginine	0-8	DEAD-box helicase 5	Homo sapiens	33-37
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Arginine	94-97	defensin beta 103B	Homo sapiens	143-148
34235626-4	2021	METHODS: The O-dealkylation rate of 7-ethoxyresorufin (EROD) by recombinant human CYP1A1 and CYP1B1, in addition to the O-dealkylation rate of 7-methoxyresorufin (MROD) by recombinant human CYP1A2, were measured in the absence and presence of varying concentrations (0-40 nM) of the synthetic analogues of 19(R)- and 19(S)-HETE.	Arginine	309-312	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
34184429-5	2021	We previously described R15, a linear peptide composed of 15 arginine molecules, as a potential UFH antagonist.	Arginine	61-69	ribonuclease A family member 2	Rattus norvegicus	24-27
34565735-3	2021	Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of L-arginine under the action of arginine decarboxylase, hence also known as decarboxylated arginine.	Arginine	117-127	antizyme inhibitor 2	Homo sapiens	148-170
34565735-3	2021	Agmatine is a polyamine substance which widely presents in mammals.It is a metabolite produced by decarboxylation of L-arginine under the action of arginine decarboxylase, hence also known as decarboxylated arginine.	Arginine	207-215	antizyme inhibitor 2	Homo sapiens	148-170
34573309-6	2021	The variant identified was a c.887G > A substitution in exon 7 of the MED12 gene leading to the substitution of a glutamine for a highly conserved arginine (p. Arg296Gln).	Arginine	147-155	mediator complex subunit 12	Homo sapiens	70-75
11559313-5	2001	RESULTS: Sequence analysis of the Notch3 gene showed a new missense mutation CGC-->TGC in codon 332 of exon 6, resulting in the replacement of an arginine residue with a cysteine.	Arginine	146-154	notch receptor 3	Homo sapiens	34-40
11513728-0	2001	Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1.	Arginine	69-72	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	40-47
34449768-7	2021	In IRS1 gene, the genotype frequency (%) of Arg/Arg was significantly higher in NAFLD and OSA subjects.	Arginine	44-47	insulin receptor substrate 1	Homo sapiens	3-7
34449768-7	2021	In IRS1 gene, the genotype frequency (%) of Arg/Arg was significantly higher in NAFLD and OSA subjects.	Arginine	48-51	insulin receptor substrate 1	Homo sapiens	3-7
34449768-8	2021	In addition, Gly/Arg genotype of IRS1 gene was associated with significantly higher body mass index, fat mass, %body fat, triglycerides, cholesterol, alkaline phosphate, aspartate transaminase, fasting insulin and HOMA-IR levels in OSA and NAFLD subjects.	Arginine	17-20	insulin receptor substrate 1	Homo sapiens	33-37
11513728-5	2001	Here we report that E1B-AP5 is methylated in vivo in its Arg-Gly-Gly (RGG)-box domain, known to mediate protein-RNA interactions.	Arginine	57-60	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	20-27
34449768-10	2021	Further we found that subjects carrying IRS1 Gly/Arg (OR 4.49, 95% C.I.	Arginine	49-52	insulin receptor substrate 1	Homo sapiens	40-44
11556547-1	2001	The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS).	Arginine	128-138	argininosuccinate synthase 1	Homo sapiens	11-39
11556547-1	2001	The enzyme argininosuccinate synthetase (ASS) is the rate limiting enzyme in the metabolic pathway leading from L-citrulline to L-arginine, the physiological substrate of all isoforms of nitric oxide synthases (NOS).	Arginine	128-138	argininosuccinate synthase 1	Homo sapiens	41-44
34328736-11	2021	According to our findings, neurons in the control group hippocampal CA1 and DG regions exhibited strong BDNF, NPY, and NMDA-R reactions, while an expression in both regions decreased in the MSG group (p < 0.00).	Arginine	124-125	carbonic anhydrase 1	Rattus norvegicus	68-71
11556547-9	2001	Because an adequate supply of L-arginine is indispensable for prolonged NO generation, coinduction of ASS enables cells to sustain NO generation during AD by replenishing necessary supply of L-arginine.	Arginine	191-201	argininosuccinate synthase 1	Homo sapiens	102-105
11494128-7	2001	A second, phosphorylation-independent interaction with EphB2 involves non-conserved sequences in the C-terminal tails of Abl and Arg.	Arginine	129-132	EPH receptor B2	Homo sapiens	55-60
34438873-7	2021	Additional Arg, Arg-Gln, and MIX suppressed (p < 0.05) the overexpression of IL-1beta generated by DEX.	Arginine	11-14	interleukin 1, beta	Gallus gallus	77-85
34438873-7	2021	Additional Arg, Arg-Gln, and MIX suppressed (p < 0.05) the overexpression of IL-1beta generated by DEX.	Arginine	16-19	interleukin 1, beta	Gallus gallus	77-85
11494128-9	2001	The connection between EphB2 and Abl/Arg appears to be reciprocal.	Arginine	37-40	EPH receptor B2	Homo sapiens	23-28
11494128-10	2001	Activated EphB2 causes tyrosine phosphorylation of Abl and Arg, and vice versa.	Arginine	59-62	EPH receptor B2	Homo sapiens	10-15
11433300-2	2001	We also show that an Arg-to-Gln mutation in the PX domain of p47phox, which is found in patients with chronic granulomatous disease, eliminates phosphoinositide binding, as does the analogous mutation in the PX domain of p40phox.	Arginine	21-24	neutrophil cytosolic factor 4	Homo sapiens	221-228
34423028-6	2021	Further analysis was also performed to find out the survival-related ARGs in HNSCC, and two prognosis-related ARGs, FADD and NKX2-3, were selected to construct a prognosis prediction model.	Arginine	110-114	Fas associated via death domain	Homo sapiens	116-120
11433300-3	2001	The PX domain of p40phox localizes specifically to PtdIns(3)P-enriched early endosomes, and this localization is disrupted by inhibition of phosphoinositide-3-OH kinase (PI(3)K) or by the Arg-to-Gln point mutation.	Arginine	188-191	neutrophil cytosolic factor 4	Homo sapiens	17-24
34423028-13	2021	Conclusions: ARGs may be a potential biomarker for HNSCC prognosis, and targeted therapies for FADD and NKX2-3 are possible to be a new strategy of HNSCC treatment.	Arginine	13-17	Fas associated via death domain	Homo sapiens	95-99
11414709-4	2001	Substitution analysis showed that the C-terminal optimal sequence of GPR54-activating peptides is Gly-Leu-Arg-Trp-NH2.	Arginine	106-109	KISS1 receptor	Homo sapiens	69-74
11412103-2	2001	Both tails were largely flexible and unstructured, although, in the beta3 tail, residues Arg(724)-Ala(735) have a propensity to form a helical structure and residues Asn(744)-Tyr(747) (NPLY) have a propensity to adopt reverse-turn conformations.	Arginine	89-92	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	68-73
11390973-2	2001	Two activating mutations, Ser-252 --&gt; Trp and Pro-253 --&gt; Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS.	Arginine	64-67	fibroblast growth factor receptor 2	Homo sapiens	72-107
34171297-0	2021	Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.	Arginine	0-8	mitochondrial antiviral signaling protein	Homo sapiens	43-47
34171297-2	2021	Here, we demonstrate that arginine monomethylation precisely regulates the mitochondrial antiviral-signaling protein (MAVS)-mediated antiviral response.	Arginine	26-34	mitochondrial antiviral signaling protein	Homo sapiens	75-116
34171297-2	2021	Here, we demonstrate that arginine monomethylation precisely regulates the mitochondrial antiviral-signaling protein (MAVS)-mediated antiviral response.	Arginine	26-34	mitochondrial antiviral signaling protein	Homo sapiens	118-122
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	mitochondrial antiviral signaling protein	Homo sapiens	74-78
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	mitochondrial antiviral signaling protein	Homo sapiens	204-208
34171297-4	2021	Upon virus infection, aggregated PRMT7 is disabled in a timely manner due to automethylation at arginine residue 32 (R32), and SMURF1 is recruited to PRMT7 by MAVS to induce proteasomal degradation of PRMT7, resulting in the relief of PRMT7 suppression of MAVS activation.	Arginine	96-104	mitochondrial antiviral signaling protein	Homo sapiens	256-260
34171297-5	2021	Therefore, we not only reveal that arginine monomethylation by PRMT7 negatively regulates MAVS-mediated antiviral signaling in vitro and in vivo but also uncover a mechanism by which PRMT7 is tightly controlled to ensure the timely activation of antiviral defense.	Arginine	35-43	mitochondrial antiviral signaling protein	Homo sapiens	90-94
11390973-2	2001	Two activating mutations, Ser-252 --&gt; Trp and Pro-253 --&gt; Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS.	Arginine	64-67	fibroblast growth factor receptor 2	Homo sapiens	109-114
11390973-5	2001	Moreover, based on these structures and sequence alignment of the FGF family, we propose that the Pro-253 --&gt; Arg mutation will indiscriminately increase the affinity of FGFR2 toward any FGF.	Arginine	113-116	fibroblast growth factor receptor 2	Homo sapiens	173-178
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	0-30
34394384-4	2021	Structural analysis showed that the molecular mass of MIPP is 831 Da, and it has a simple amino acid sequence: Ser-Leu-Ser-Leu-Ser-Val-Ala-Arg.	Arginine	139-142	multiple inositol-polyphosphate phosphatase 1	Homo sapiens	54-58
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	32-35
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	76-79
11274154-1	2001	Macrophage stimulating protein (MSP) is secreted as 78-kDa single chain pro-MSP, which is converted to biologically active, disulfide-linked alphabeta chain MSP by cleavage at Arg(483)-Val(484).	Arginine	176-179	macrophage stimulating 1	Homo sapiens	76-79
34344457-13	2021	ASS1 expression in cancer cells would allow Arg fueling of iNOS+TILs and enhance anti-tumor immunity.	Arginine	44-47	argininosuccinate synthase 1	Homo sapiens	0-4
11380262-2	2001	Heparin has been proposed to conformationally activate the serpin, antithrombin, by making the reactive center loop P1 arginine residue accessible to proteinases.	Arginine	119-127	serpin family C member 1	Homo sapiens	67-79
34360842-7	2021	Our functional and structural analyses showed that the p47 binding is likely to impact the p97R155H ATPase activities via changing the conformations of arginine fingers.	Arginine	152-160	pleckstrin	Homo sapiens	55-58
11380262-3	2001	To evaluate this proposal, we determined the effect of mutating the P1 arginine on antithrombin"s specificity for target and nontarget proteinases in both native and heparin-activated states of the serpin.	Arginine	71-79	serpin family C member 1	Homo sapiens	83-95
11380262-4	2001	As expected, mutation of the P1 arginine to tryptophan, histidine, leucine, and methionine converted the specificity of antithrombin from a trypsin inhibitor (k(assoc) = 2 x 10(5) M(-1) s(-1)) to a chymotrypsin inhibitor (k(assoc) = 10(3)-10(5) M(-1) s(-1)).	Arginine	32-40	serpin family C member 1	Homo sapiens	120-132
11380262-6	2001	Mutation of the P1 arginine greatly reduced k(assoc) for antithrombin inhibition of thrombin and factor Xa from 40- to 5000-fold, but heparin normally accelerated the reactions of the variant antithrombins with these enzymes to make them reasonably efficient inhibitors (k(assoc) = 10(3)-10(4) M(-1) s(-1)).	Arginine	19-27	serpin family C member 1	Homo sapiens	57-69
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Arginine	120-128	argininosuccinate synthase 1	Homo sapiens	163-167
11380262-10	2001	Together, these findings suggest that the P1 arginine residue is similarly accessible to proteinases in both native and heparin-activated states of the serpin and contributes similarly to the specificity of antithrombin for thrombin and factor Xa in the two serpin conformational states.	Arginine	45-53	serpin family C member 1	Homo sapiens	207-219
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Arginine	120-128	argininosuccinate synthase 1	Homo sapiens	169-197
34298755-4	2021	Strikingly, in over 70% of tumors, ASS1 transcription is suppressed, rendering the cells addicted to external arginine, forming the basis of arginine-deprivation therapy.	Arginine	110-118	argininosuccinate synthase 1	Homo sapiens	35-39
34298755-4	2021	Strikingly, in over 70% of tumors, ASS1 transcription is suppressed, rendering the cells addicted to external arginine, forming the basis of arginine-deprivation therapy.	Arginine	141-149	argininosuccinate synthase 1	Homo sapiens	35-39
11397844-6	2001	Migration stimulation by IGFBP-1 was abrogated by pretreatment with a Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), but not a Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) hexapeptide, and by mutation of the RGD domain of IGFBP-1 to Trp-Gly-Asp (WGD).	Arginine	74-77	insulin like growth factor binding protein 1	Homo sapiens	25-32
34299050-6	2021	Principal component analysis of the cancer cells revealed that all these changes were in the first principal component (PC1) axis, where the responsible metabolites were involved in the metabolism of the arginine-proline, pyrimidine, and pentose phosphate pathways.	Arginine	204-212	proprotein convertase subtilisin/kexin type 1	Homo sapiens	120-123
11397844-6	2001	Migration stimulation by IGFBP-1 was abrogated by pretreatment with a Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP), but not a Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) hexapeptide, and by mutation of the RGD domain of IGFBP-1 to Trp-Gly-Asp (WGD).	Arginine	74-77	insulin like growth factor binding protein 1	Homo sapiens	197-204
11384198-2	2001	Citrulline formed by the NOS reaction is recycled to arginine by the citrulline-NO cycle, which is composed of NOS, argininosuccinate synthetase (AS), and argininosuccinate lyase.	Arginine	53-61	argininosuccinate lyase	Rattus norvegicus	155-178
11306718-0	2001	Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium.	Arginine	110-118	carboxypeptidase D	Homo sapiens	0-18
34155405-1	2021	In the present study, we report a human-inherited, impaired, adaptive immunity disorder, which predominantly manifested as a B cell differentiation defect, caused by a heterozygous IKZF3 missense variant, resulting in a glycine-to-arginine replacement within the DNA-binding domain of the encoded AIOLOS protein.	Arginine	231-239	IKAROS family zinc finger 3	Homo sapiens	181-186
34155405-1	2021	In the present study, we report a human-inherited, impaired, adaptive immunity disorder, which predominantly manifested as a B cell differentiation defect, caused by a heterozygous IKZF3 missense variant, resulting in a glycine-to-arginine replacement within the DNA-binding domain of the encoded AIOLOS protein.	Arginine	231-239	IKAROS family zinc finger 3	Homo sapiens	297-303
11306718-1	2001	Membrane-bound carboxypeptidase D (CPD) is a B-type carboxypeptidase that specifically cleaves C-terminal Arg or Lys from peptides and proteins.	Arginine	106-109	carboxypeptidase D	Homo sapiens	15-33
11306718-1	2001	Membrane-bound carboxypeptidase D (CPD) is a B-type carboxypeptidase that specifically cleaves C-terminal Arg or Lys from peptides and proteins.	Arginine	106-109	carboxypeptidase D	Homo sapiens	35-38
11306718-7	2001	In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg.	Arginine	46-49	carboxypeptidase D	Homo sapiens	63-66
34157815-10	2021	Results: Serum levels of amylase and lipase were significantly (p<0.001) reduced in L-arginine-treated rats.	Arginine	84-94	lipase G, endothelial type	Rattus norvegicus	37-43
11306718-7	2001	In cells stimulated with IFN-gamma and LPS in Arg-free medium, CPD activity increased 2- to 3-fold between 8 and 16 h after treatment, but did not change in cells stimulated in medium containing 0.4 mM Arg.	Arginine	202-205	carboxypeptidase D	Homo sapiens	63-66
11306718-8	2001	The NO synthase inhibitor N-monomethyl-L-arginine blocked the inhibitory Arg effect and the NO donor S-nitroso-acetylpenicillamine mimicked it, indicating that high levels of NO block the up-regulation of CPD.	Arginine	73-76	carboxypeptidase D	Homo sapiens	205-208
11306718-9	2001	Immunohistochemical staining and Western analysis revealed an increase in CPD protein, and Northern analysis showed increased CPD mRNA upon stimulation of cells in Arg-free medium.	Arginine	164-167	carboxypeptidase D	Homo sapiens	126-129
11306718-11	2001	These data suggest that CPD expression is enhanced during inflammatory processes and may stimulate NO production by cleaving Arg from peptide substrates.	Arginine	125-128	carboxypeptidase D	Homo sapiens	24-27
11118443-4	2001	Like several other proteins involved in constitutive and regulated splicing, both U2AF(65) and U2AF(35) contain an arginine/serine-rich (RS) domain.	Arginine	115-123	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	82-90
34204566-0	2021	Transient Reduction of FMD-Response and L-Arginine Accompanied by Increased Levels of E-Selectin, VCAM, and ICAM after Prolonged Strenuous Exercise.	Arginine	40-50	selectin E	Homo sapiens	86-96
11118443-4	2001	Like several other proteins involved in constitutive and regulated splicing, both U2AF(65) and U2AF(35) contain an arginine/serine-rich (RS) domain.	Arginine	115-123	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	95-102
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Arginine	278-281	neurolysin	Homo sapiens	290-300
34099711-4	2021	We demonstrate that proline/arginine repeat polymers inhibit the folding catalyst activity of PPIA, an abundant molecular chaperone and prolyl isomerase in the brain that is altered in amyotrophic lateral sclerosis.	Arginine	28-36	peptidylprolyl isomerase A	Homo sapiens	94-98
11284698-5	2001	No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg.	Arginine	308-311	neurolysin	Homo sapiens	290-300
34099711-5	2021	NMR spectroscopy reveals that proline/arginine repeat polymers bind to the active site of PPIA.	Arginine	38-46	peptidylprolyl isomerase A	Homo sapiens	90-94
11115503-3	2001	We previously showed that arginine, not simply a positive charge, at residue 3500 is essential for normal receptor binding and that the carboxyl terminus of apoB100 is necessary for mutations affecting arginine 3500 to disrupt LDL receptor binding.	Arginine	202-210	apolipoprotein B	Mus musculus	157-164
11115503-4	2001	Thus, normal receptor binding involves an interaction between arginine 3500 and tryptophan 4369 in the carboxyl tail of apoB100.	Arginine	62-70	apolipoprotein B	Mus musculus	120-127
33802597-7	2021	In contrast, arginine biosynthesis was correlated with sensitivity to HSP90 inhibitors.	Arginine	13-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	70-75
11115503-6	2001	We conclude that arginine 3500 interacts with tryptophan 4369 and facilitates the conformation of apoB100 required for normal receptor binding of LDL.	Arginine	17-25	apolipoprotein B	Mus musculus	98-105
11277994-3	2001	Data from the crystalline structure of homologous Escherichia coli PEP carboxykinase suggest that Arg(333) may be involved in stabilization of enolpyruvate, a postulated reaction intermediate.	Arginine	98-101	phosphoenolpyruvate carboxykinase 1	Homo sapiens	67-84
34179867-0	2021	Early glutathione intervention educed positive correlation between VGLUT1 expression and spatial memory in the Nomega-nitro-L-arginine methyl rat model of IUGR.	Arginine	124-134	solute carrier family 17 member 7	Rattus norvegicus	67-73
34090290-8	2021	CONCLUSION: Conclusions: Analysis of Arg16Gly polymorphic variants in the beta2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma.	Arginine	157-160	adenosine A2a receptor	Homo sapiens	74-82
34090290-8	2021	CONCLUSION: Conclusions: Analysis of Arg16Gly polymorphic variants in the beta2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma.	Arginine	161-164	adenosine A2a receptor	Homo sapiens	74-82
34090290-8	2021	CONCLUSION: Conclusions: Analysis of Arg16Gly polymorphic variants in the beta2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma.	Arginine	166-169	adenosine A2a receptor	Homo sapiens	74-82
34090290-8	2021	CONCLUSION: Conclusions: Analysis of Arg16Gly polymorphic variants in the beta2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma.	Arginine	283-286	adenosine A2a receptor	Homo sapiens	74-82
11160269-4	2001	Addition of exogenous arginine completely restored NO production in IL-4-treated macrophages.	Arginine	22-30	interleukin 4	Mus musculus	68-72
11160269-5	2001	Furthermore, impaired killing of the intracellular pathogen Toxoplasma gondii in IL-4-treated macrophages was overcome by supplementing L-arginine.	Arginine	136-146	interleukin 4	Mus musculus	81-85
11327827-7	2001	Recombinant prostin readily activates the precursor of PSA (pro-PSA) by cleavage of the amino terminal Arg(7)-Ile(8) peptide bond.	Arginine	103-106	kallikrein related peptidase 3	Homo sapiens	55-58
34090290-8	2021	CONCLUSION: Conclusions: Analysis of Arg16Gly polymorphic variants in the beta2-AR gene showed a statistically significant difference in the distribution of Arg/Arg, Arg/Gly, and Gly/Gly genotypes in patients with BA and apparently healthy individuals due to the higher frequency of Arg/Arg genotype in controls and higher frequency of Gly/Gly genotype in patients with asthma.	Arginine	287-290	adenosine A2a receptor	Homo sapiens	74-82
11327827-7	2001	Recombinant prostin readily activates the precursor of PSA (pro-PSA) by cleavage of the amino terminal Arg(7)-Ile(8) peptide bond.	Arginine	103-106	kallikrein related peptidase 3	Homo sapiens	64-67
11157057-2	2001	Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264K and R264G) results in epitopes that bind to HLA-B27 poorly.	Arginine	46-54	major histocompatibility complex, class I, B	Homo sapiens	135-142
35583463-6	2022	Furthermore, l -arginine contributed to the expression of phase II detoxification genes (SULT2B1, GSTA1, GSTM3, and GPX4).	Arginine	13-24	glutathione peroxidase 4	Homo sapiens	116-120
11229429-0	2001	Contrasting effects of L-arginine on insulin-mediated blood flow and glucose disposal in the elderly.	Arginine	23-33	insulin	Bos taurus	37-44
35616019-0	2022	L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	0-10	G protein-coupled receptor, family C, group 6, member A	Mus musculus	146-152
35616019-0	2022	L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	0-10	mechanistic target of rapamycin kinase	Mus musculus	162-166
35616019-7	2022	Furthermore, GPRC6A was knocked down or inhibition of the PI3K/AKT/mTOR signalling pathway with corresponding inhibitors completely abolished the arginine-induced promotion of mMECs proliferation.	Arginine	146-154	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	63-66
11229429-3	2001	We tested the hypothesis that L-arginine, the endogenous precursor for NO synthesis, would augment insulin-mediated vasodilation and in so doing increase insulin-mediated glucose uptake (IMGU) in healthy elderly subjects.	Arginine	30-40	insulin	Bos taurus	99-106
35616019-7	2022	Furthermore, GPRC6A was knocked down or inhibition of the PI3K/AKT/mTOR signalling pathway with corresponding inhibitors completely abolished the arginine-induced promotion of mMECs proliferation.	Arginine	146-154	mechanistic target of rapamycin kinase	Mus musculus	67-71
35616019-8	2022	In vivo, it was further confirmed that 0.1% L-arginine can activate the PI3K/AKT/mTOR signalling pathway in the MG of pubertal mice.	Arginine	44-54	mechanistic target of rapamycin kinase	Mus musculus	81-85
11229429-3	2001	We tested the hypothesis that L-arginine, the endogenous precursor for NO synthesis, would augment insulin-mediated vasodilation and in so doing increase insulin-mediated glucose uptake (IMGU) in healthy elderly subjects.	Arginine	30-40	insulin	Bos taurus	154-161
35616019-9	2022	These results were able to indicate that L-arginine stimulates the development of MG in pubertal mice through the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	41-51	G protein-coupled receptor, family C, group 6, member A	Mus musculus	114-120
35616019-9	2022	These results were able to indicate that L-arginine stimulates the development of MG in pubertal mice through the GPRC6A/PI3K/AKT/mTOR signalling pathway.	Arginine	41-51	mechanistic target of rapamycin kinase	Mus musculus	130-134
11166181-9	2001	Mutation studies suggest that a second conserved arginine (Arg48) also contributes to the GTPase active site of the eIF2.eIF5 complex.	Arginine	49-57	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	116-120
35609127-5	2022	PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of NF-kappaB signaling.	Arginine	29-37	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	146-196
35609127-5	2022	PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of NF-kappaB signaling.	Arginine	29-37	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	198-202
11732605-7	2001	Contacts between MetRS and other proteins could be mediated not only by noncatalytic peptides but also by structural elements present in the catalytic core, e.g. Arg-Gly-Asp (RGD) motifs.	Arginine	162-165	methionyl-tRNA synthetase 1	Homo sapiens	17-22
35586977-4	2022	APPROACH AND RESULTS: Using A549 cells transduced with a lentivirus K18 construct and high-throughput screening, we identified the SRC-family tyrosine kinases inhibitor, PP2, as a compound that reverses keratin filament disruption and protects from apoptotic cell death caused by K18 R90C mutation at this highly conserved arginine.	Arginine	323-331	Rous sarcoma oncogene	Mus musculus	131-134
35580065-7	2022	In HEK293T cells expressing human KCNQ1 and KCNE1, inhibiting PRMT1 via furamidine reduced IKs and concurrently decreased the arginine methylation of KCNQ1, a pore-forming alpha-subunit.	Arginine	126-134	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	34-39
35580065-7	2022	In HEK293T cells expressing human KCNQ1 and KCNE1, inhibiting PRMT1 via furamidine reduced IKs and concurrently decreased the arginine methylation of KCNQ1, a pore-forming alpha-subunit.	Arginine	126-134	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	150-155
11169446-6	2001	In Fab S20, the Arg(30) and Asp(31) somatically replaced residues in HCDR1 improved antigen binding.	Arginine	16-19	FA complementation group B	Homo sapiens	3-6
35625861-6	2022	The most frequent association of ARG in VRE was vanA-tet(M)-ermB.	Arginine	33-36	erythromycin resistance protein	Enterococcus faecalis	60-64
11169446-9	2001	Molecular modeling of S20 HCDR1 suggests that Arg(30) and Asp(31) are the main interaction sites for gp120, increasing antibody affinity and promoting the enhanced neutralization ability of S20.	Arginine	46-49	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	101-106
11811790-2	2001	We have mutated residues A54 and L55 of IGF-II in the second A domain helix to arginine (found in the corresponding positions of IGF-I) and measured IGF2R binding.	Arginine	79-87	insulin like growth factor 2	Homo sapiens	40-46
11769388-3	2001	Mutation of the gene coding beta 3 AR in position 64 with thymidine instead of cytosine leads to the replacement of tryptophan (Trp 64) with arginine (Arg 64) and may be the cause of greater increase in body mass and the decrease in basic metabolism.	Arginine	151-154	adrenoceptor beta 3	Homo sapiens	28-37
35530975-0	2022	A Ternary Synergistic eNOS Gene Delivery System Based on Calcium Ion and L-Arginine for Accelerating Angiogenesis by Maximizing NO Production.	Arginine	73-83	nitric oxide synthase 3, endothelial cell	Mus musculus	22-26
35530975-1	2022	Purpose: This study aimed to construct a delivery system based on L-arginine-modified calcium phosphate (CaP) to load eNOS plasmids (peNOS), which could amply nitric oxide (NO) to repair endothelial damage, promote angiogenic activities and alleviate inflammation.	Arginine	66-76	nitric oxide synthase 3, endothelial cell	Mus musculus	118-122
35530975-5	2022	Results: L-arginine modification augmented the transfection efficiency of CaP/peNOS to elevate the eNOS expression, and then served as NO substrate catalyzed by eNOS.	Arginine	9-19	nitric oxide synthase 3, endothelial cell	Mus musculus	99-103
35530975-5	2022	Results: L-arginine modification augmented the transfection efficiency of CaP/peNOS to elevate the eNOS expression, and then served as NO substrate catalyzed by eNOS.	Arginine	9-19	nitric oxide synthase 3, endothelial cell	Mus musculus	161-165
11150524-3	2000	We have found that mutagenesis of Thr-377 in the conserved Thr-Arg-Phe (TRF) motif of Xchk1 also leads to a substantial increase in kinase activity.	Arginine	63-66	checkpoint kinase 1 L homeolog	Xenopus laevis	86-91
11119723-2	2000	Some defects such as the regulation of arginine metabolism observed in an arg82Delta, result from a lack of Mcm1 and Arg80 stability.	Arginine	39-47	transcription factor MCM1	Saccharomyces cerevisiae S288C	108-112
35393860-4	2022	The positron emission tomography (PET) imaging tracer, 68Ga-labeled antagonist peptide Trp-Arg-Trp-Trp-Trp-Trp (WRWWWW, WRW4), targets formyl peptide receptor 2 (FPR2), which is in turn widely distributed in a variety of tissues and is associated with many inflammatory diseases.	Arginine	91-94	formyl peptide receptor 2	Homo sapiens	162-166
35490408-2	2022	Mammalian cells expressing CaMKKalpha and CaMKKbeta lacking Arg/Pro-rich insert domain (RP-domain) sequences showed impaired phosphorylation of AMPKalpha, CaMKIalpha, and CaMKIV, whereas the autophosphorylation activities of CaMKK mutants remained intact and were similar to those of wild type CaMKKs.	Arginine	60-63	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	225-230
11119723-2	2000	Some defects such as the regulation of arginine metabolism observed in an arg82Delta, result from a lack of Mcm1 and Arg80 stability.	Arginine	39-47	Arg80p	Saccharomyces cerevisiae S288C	117-122
35535157-6	2022	MI/R-induced expression of IL-6, TNF-alpha, and IL-1beta in the hearts was reduced by LrB treatment.	Arginine	3-4	interleukin 1 alpha	Mus musculus	48-56
11119723-4	2000	Arg82 mutations keeping kinase active affect the expression of arginine genes, whereas mutations in the kinase domain do not impair this metabolic control.	Arginine	63-71	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-5
35500745-5	2022	PRMT5 and symmetric dimethylation at histone H4 arginine 3 (H4R3me2s) directly associate with chromatin of P21 to suppress its transcription.	Arginine	48-56	H3 histone pseudogene 16	Homo sapiens	107-110
11083624-8	2000	The main conclusions are that the first two arginines at the N terminus of hLF are critical in the candidacidal activity of hLF(1-11) and that extracellular ATP is essential but not sufficient for the peptide to exert its candidacidal activity.	Arginine	44-53	HLF transcription factor, PAR bZIP family member	Homo sapiens	75-78
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	121-131	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	121-131	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	133-136	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	133-136	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	158-161	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	88-92
35563125-1	2022	L-Arginine:glycine amidinotransferase (AGAT) catalyzes the formation of L-homoarginine (hArg) and L-ornithine (Orn) from L-arginine (Arg) and L-lysine (Lys): Arg + Lys   hArg + Orn; equilibrium constant KhArg.	Arginine	158-161	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	170-174
35563125-9	2022	Our results suggest that Lys and Arg are major metabolites of pharmacological hArg.	Arginine	33-36	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	78-82
11083624-8	2000	The main conclusions are that the first two arginines at the N terminus of hLF are critical in the candidacidal activity of hLF(1-11) and that extracellular ATP is essential but not sufficient for the peptide to exert its candidacidal activity.	Arginine	44-53	HLF transcription factor, PAR bZIP family member	Homo sapiens	124-127
11099402-3	2000	The patient was a compound heterozygote for a novel missense mutation (G(568)GA--&gt;AGA/Gly(105)--&gt;Arg; G105R) in exon 3 and a missense mutation (GAC(867)--&gt;GAG/Asp(204)--&gt;Glu; D204E) in exon 5 of the LPL gene.	Arginine	103-106	lipoprotein lipase	Homo sapiens	211-214
35462078-8	2022	Interestingly, we found two Arginine fingers R68 and R149 that directly interact with the beta-phosphate of the GTP bound in KRas, in a manner similar to what is observed in a crystal structure of GAP-HRas complex, which can facilitate the GPT hydrolysis via the Arginine finger of GTPase-activating protein (GAP).	Arginine	28-36	HRas proto-oncogene, GTPase	Homo sapiens	201-205
35379776-6	2022	We further identified that PRMT5 promoted VCAM-1 expression via symmetrical demethylation of Nuclear factor-kappaB p65 on arginine 30 (R30).	Arginine	122-130	vascular cell adhesion molecule 1	Mus musculus	42-48
11093766-2	2000	Lipopolysaccharides (LPSs) and interferon-gamma stimulated in the same concentration- and time-dependent manner NO synthesis (measured by nitrite accumulation) and L-[(3)H]arginine uptake.	Arginine	172-180	interferon gamma	Rattus norvegicus	31-47
34998113-2	2022	The objective of this study was to investigate age-dependent changes in the daily regulation of Arg-Phe amide-related peptide-3 (RFRP-3), a hypothalamic peptide involved in reproduction, in female C57BL/6 J mice of different age groups (4, 13, and 19 months old) sampled at their diestrus stage.	Arginine	96-99	neuropeptide VF precursor	Mus musculus	129-133
34982085-7	2022	The most clinically relevant discovery is the downregulation of the arginine biosynthesis pathway, likely due to blocked argininosuccinate synthase, which is congruent with the MELAS cardinal symptom of stroke-like episodes and its current treatment by arginine infusion.	Arginine	68-76	argininosuccinate synthase 1	Homo sapiens	121-147
11101900-2	2000	Hmt1/Rmt1, the major arginine methyltransferase in yeast, catalyzes methylation of arginine residues in several mRNA-binding proteins and facilitates their export from the nucleus.	Arginine	21-29	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	0-4
11101900-2	2000	Hmt1/Rmt1, the major arginine methyltransferase in yeast, catalyzes methylation of arginine residues in several mRNA-binding proteins and facilitates their export from the nucleus.	Arginine	21-29	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	5-9
11072090-2	2000	NO is synthesized from arginine by nitric oxide synthase (NOS), and the citrulline generated as a by-product can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL) via the citrulline-NO cycle.	Arginine	128-136	argininosuccinate lyase	Rattus norvegicus	178-201
34982085-7	2022	The most clinically relevant discovery is the downregulation of the arginine biosynthesis pathway, likely due to blocked argininosuccinate synthase, which is congruent with the MELAS cardinal symptom of stroke-like episodes and its current treatment by arginine infusion.	Arginine	253-261	argininosuccinate synthase 1	Homo sapiens	121-147
11072090-2	2000	NO is synthesized from arginine by nitric oxide synthase (NOS), and the citrulline generated as a by-product can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL) via the citrulline-NO cycle.	Arginine	128-136	argininosuccinate lyase	Rattus norvegicus	203-205
35359596-6	2022	The S93 residue, which is located at the first Greek-key motif of betaB1-crystallin, is highly conserved, and its substitution to Arginine severely impaired hydrogen bonds and structural conformation, which were evaluated via Molecular Dynamic Simulation.	Arginine	130-138	crystallin beta B1	Homo sapiens	66-83
11057443-1	2000	The 25-amino-acid leader peptide present at the 5" end of yeast CPA1 mRNA is responsible for the translational repression of that gene by arginine.	Arginine	138-146	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	64-68
35201898-4	2022	ACE inhibition enhanced micro-opioid receptor activation by Met-enkephalin-Arg-Phe, causing a cell type-specific long-term depression of glutamate release onto medium spiny projection neurons expressing the Drd1 dopamine receptor.	Arginine	75-78	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	0-3
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	calpain 1	Homo sapiens	132-137
11029061-7	2000	In the deduced sequence of Wpkci, the HIT motif, which is essential for PKCI function, was absent, but the alpha-helix region, which was conserved among the PKCI family, and a unique Leu- and Arg-rich region, were present.	Arginine	192-195	histidine triad nucleotide-binding protein 1-like	Gallus gallus	27-32
35199385-7	2022	Protein-protein interaction and transcription factor analyses suggested that Trp53 and Nr4a2 genes may play key roles during arginine stimulation.	Arginine	125-133	transformation related protein 53	Mus musculus	77-82
35137127-0	2022	Insulin signaling and antioxidant proteins in adipose tissue explants from dairy cows challenged with hydrogen peroxide are altered by supplementation of arginine or arginine plus methionine.	Arginine	154-162	insulin	Bos taurus	0-7
35137127-0	2022	Insulin signaling and antioxidant proteins in adipose tissue explants from dairy cows challenged with hydrogen peroxide are altered by supplementation of arginine or arginine plus methionine.	Arginine	166-174	insulin	Bos taurus	0-7
10973788-2	2000	Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by successive actions of argininosuccinate synthetase (AS) and argininosuccinate lyase (AL), forming the citrulline-NO cycle.	Arginine	84-92	argininosuccinate lyase	Rattus norvegicus	156-179
10981554-1	2000	A missense mutation of the beta3-adrenergic receptor gene (ADRB3) resulting in a tryptophan/arginine exchange at position 64 (Trp64Arg polymorphism) has recently been associated with greater capacity to gain weight, a low resting metabolic rate, higher blood pressure, and an early onset of type 2 diabetes.	Arginine	92-100	adrenoceptor beta 3	Homo sapiens	27-52
35216250-1	2022	INTRODUCTION: L-Arginine (Arg) is a semi-essential amino acid.	Arginine	14-24	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	26-29
35101895-3	2022	We have previously described an L-ARG synthesis pathway in immune cells; however, its role in APCs has yet to be uncovered.	Arginine	32-37	amyloid P component, serum	Homo sapiens	94-98
35101895-5	2022	We hypothesize that APCs supply L-ARG to support T cell activation under nutrient-limiting conditions.	Arginine	32-37	amyloid P component, serum	Homo sapiens	20-24
35243242-4	2022	Exploring this divergence, proliferation assays with multiple ALL cell lines revealed that the KRAS-G12D rewired methionine and arginine metabolism.	Arginine	128-136	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	95-99
35243242-5	2022	Isotope tracing results showed that KRAS-G12D promotes catabolism of methionine and arginine to support anabolism of polyamines and proline, respectively.	Arginine	84-92	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	36-40
35134872-7	2022	Furthermore, L-arginine, a selective GPRC6A agonist, was administered to mice with colitis.	Arginine	13-23	G protein-coupled receptor, family C, group 6, member A	Mus musculus	37-43
35134872-10	2022	Further studies showed that L-arginine, a GPRC6A agonist, promoted colonic ILC3 expansion and function via mammalian target of rapamycin complex 1 (mTORC1) signalling in vitro.	Arginine	28-38	G protein-coupled receptor class C group 6 member A	Homo sapiens	42-48
35140112-15	2022	This is distinct from PAD4 citrullination of arginine 197 within NPM which results in its transport from the nucleoli to the nucleoplasm.	Arginine	45-53	peptidyl arginine deiminase 4	Homo sapiens	22-26
34982532-6	2022	The site-selective chirality growth of the cys-chiral AuNPs is ascribed to the morphology evolution induced by the synergy of cys and R/L-CP light, which is clearly analyzed and elucidated with high CD intensities.	Arginine	134-135	ceruloplasmin	Homo sapiens	138-140
34992216-0	2022	Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression.	Arginine	30-38	UPF1 RNA helicase and ATPase	Homo sapiens	70-74
35072516-8	2022	Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure.	Arginine	47-55	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	104-113
35072516-8	2022	Study participants who were homozygous for p53 arginine compared with the proline variant showed higher mucin 5AC (MUC5AC) mRNA levels in nasal brushings if they reported WS exposure.	Arginine	47-55	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	115-121
35072516-9	2022	The WS constituent, oxalate, increased MUC5AC levels similar to the whole WS extract, especially in primary human AECs homozygous for p53 arginine, and in mice with a modified Tp53 gene.	Arginine	138-146	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	39-45
35438581-9	2022	Additionally, the protein levels of TLR4, MyD88 and p-P65 NF-kappaB were obviously increased after H/R stimulation, whereas the addition of UA could alter the phenomena by reducing TLR4, MyD88, and p-P65 NF-kappaB expression.	Arginine	101-102	toll like receptor 4	Homo sapiens	36-40
35438581-9	2022	Additionally, the protein levels of TLR4, MyD88 and p-P65 NF-kappaB were obviously increased after H/R stimulation, whereas the addition of UA could alter the phenomena by reducing TLR4, MyD88, and p-P65 NF-kappaB expression.	Arginine	101-102	toll like receptor 4	Homo sapiens	181-185
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	Arginine	62-63	toll like receptor 4	Homo sapiens	114-118
10981554-1	2000	A missense mutation of the beta3-adrenergic receptor gene (ADRB3) resulting in a tryptophan/arginine exchange at position 64 (Trp64Arg polymorphism) has recently been associated with greater capacity to gain weight, a low resting metabolic rate, higher blood pressure, and an early onset of type 2 diabetes.	Arginine	92-100	adrenoceptor beta 3	Homo sapiens	59-64
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Arginine	207-210	EcoRII restriction enzyme	Escherichia coli	33-39
11042490-2	2000	Plasmids with point mutations in ecoRII gene resulting in substitutions of amino acid residues in the Asp110-Glu112 region of the EcoRII endonuclease (Asp110 --&gt; Lys, Asn, Thr, Val, or Ile; Pro111 --&gt; Arg, His, Ala, or Leu; Glu112 --&gt; Lys, Gln, or Asp) have been constructed.	Arginine	207-210	EcoRII restriction enzyme	Escherichia coli	130-136
10933889-3	2000	We have previously demonstrated the importance for RA binding and RA-dependent transactivation of Arg(276) in RARalpha and Arg(278) in RARgamma; however, in RARbeta Arg(269) functions in conjunction with Lys(220).	Arginine	98-101	retinoic acid receptor alpha	Homo sapiens	110-118
10903140-0	2000	The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.	Arginine	63-71	solute carrier family 3 member 2	Homo sapiens	41-46
10903140-3	2000	Arginine release in mammalian cells can be mediated by two different transporters, y(+)LAT1 and y(+)LAT2.	Arginine	0-8	solute carrier family 7 member 7	Homo sapiens	83-104
10903140-9	2000	When co-expressed with 4F2hc in Xenopus laevis oocytes, y(+)LAT2 mediated uptake of arginine, leucine and glutamine.	Arginine	84-92	solute carrier family 3 member 2	Homo sapiens	23-28
10903140-9	2000	When co-expressed with 4F2hc in Xenopus laevis oocytes, y(+)LAT2 mediated uptake of arginine, leucine and glutamine.	Arginine	84-92	solute carrier family 7 member 8 L homeolog	Xenopus laevis	60-64
10903143-5	2000	According to the crystal structure of HSA, the residues Arg-410 and Tyr-411 protrude into the centre of site II (in subdomain 3A), and the binding results showed that the guanidino moiety of Arg-410, the phenolic oxygen and the aromatic ring of Tyr-411 are important for ketoprofen binding.	Arginine	56-59	CD24 molecule	Rattus norvegicus	38-41
10903143-5	2000	According to the crystal structure of HSA, the residues Arg-410 and Tyr-411 protrude into the centre of site II (in subdomain 3A), and the binding results showed that the guanidino moiety of Arg-410, the phenolic oxygen and the aromatic ring of Tyr-411 are important for ketoprofen binding.	Arginine	191-194	CD24 molecule	Rattus norvegicus	38-41
11204523-2	2000	The substitution of arginine (R) to histidine (H) at amino acid residue 156 (R156H) of coiled 1A region is one of the most frequent mutations of KRT10.	Arginine	20-28	keratin 10	Homo sapiens	145-150
10871321-7	2000	BK1-5 (Arg-Pro-Pro-Gly-Phe), the 1-to-5 amino acid fragment of bradykinin, was identified as a major stable plasma metabolite of bradykinin.	Arginine	7-10	bradykinin receptor B2	Homo sapiens	0-5
10764763-0	2000	Role of arginine 129 in heparin binding and activation of antithrombin.	Arginine	8-16	serpin family C member 1	Homo sapiens	58-70
10764763-1	2000	The contribution of Arg(129) of the serpin, antithrombin, to the mechanism of allosteric activation of the protein by heparin was determined from the effect of mutating this residue to either His or Gln.	Arginine	20-23	serpin family C member 1	Homo sapiens	44-56
10764763-6	2000	These results support an important role for Arg(129) in an induced-fit mechanism of heparin activation of antithrombin wherein conformational activation of the serpin positions Arg(129) and other residues for cooperative interactions with the heparin pentasaccharide so as to lock the serpin in the activated state.	Arginine	44-47	serpin family C member 1	Homo sapiens	106-118
10764763-6	2000	These results support an important role for Arg(129) in an induced-fit mechanism of heparin activation of antithrombin wherein conformational activation of the serpin positions Arg(129) and other residues for cooperative interactions with the heparin pentasaccharide so as to lock the serpin in the activated state.	Arginine	177-180	serpin family C member 1	Homo sapiens	106-118
10818253-2	2000	His(185) has only been reported in hCRF(2); CRF(2) proteins from other species and all CRF(1) receptors encode an arginine (Arg(185)) at the corresponding position.	Arginine	124-127	corticotropin releasing hormone	Homo sapiens	35-39
10818253-3	2000	Cloning of partial and full-length hCRF(2) cDNAs from a variety of neuronal and peripheral tissues revealed the existence of receptor molecules encoding Arg(185) only.	Arginine	153-156	corticotropin releasing hormone	Homo sapiens	35-39
10818253-4	2000	Sequence analysis of the hCRF(2) gene verified the existence of Arg(185) also on genomic level.	Arginine	64-67	corticotropin releasing hormone	Homo sapiens	25-29
10818253-8	2000	These data indicate that hCRF(2), like all vertebrate CRF(1) and CRF(2) proteins encodes an arginine residue at the junction between extracellular domain 2 and transmembrane domain 3 and that this amino acid plays a role for the discrimination of some CRF peptide ligands.	Arginine	92-100	corticotropin releasing hormone	Homo sapiens	25-29
10818253-8	2000	These data indicate that hCRF(2), like all vertebrate CRF(1) and CRF(2) proteins encodes an arginine residue at the junction between extracellular domain 2 and transmembrane domain 3 and that this amino acid plays a role for the discrimination of some CRF peptide ligands.	Arginine	92-100	corticotropin releasing hormone receptor 2	Homo sapiens	26-32
10845864-4	2000	Cultured VSMCs from Wistar-Kyoto rats were incubated with an active fragment of FN, Arg-Gly-Asp-Ser, for 24, 48, or 72 hours after synchronization of the cell cycle with 0.	Arginine	84-87	fibronectin 1	Rattus norvegicus	80-82
10809695-0	2000	In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex.	Arginine	43-51	arginase	Saccharomyces cerevisiae S288C	68-72
10809695-0	2000	In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex.	Arginine	43-51	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	77-81
10809695-1	2000	The products of three genes named CARGRI, CARGRII, and CARGRIII were shown to repress the expression of CAR1 and CAR2 genes, involved in arginine catabolism.	Arginine	137-145	arginase	Saccharomyces cerevisiae S288C	104-108
10809695-1	2000	The products of three genes named CARGRI, CARGRII, and CARGRIII were shown to repress the expression of CAR1 and CAR2 genes, involved in arginine catabolism.	Arginine	137-145	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	113-117
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	123-131	arginase	Saccharomyces cerevisiae S288C	156-160
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	123-131	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	165-169
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	247-255	arginase	Saccharomyces cerevisiae S288C	156-160
10809695-7	2000	Upon nitrogen depletion, repression at URS1 is released and Ume6 interacts with ArgRI and ArgRII, two proteins involved in arginine-dependent activation of CAR1 and CAR2, leading to high levels of the two catabolic enzymes despite a low cytosolic arginine pool.	Arginine	247-255	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	165-169
10801753-4	2000	L-Arginine, the principal substrate for nitric oxide synthases, added to the media suppressed the induction of TF activity significantly (by 66% for lipopolysaccharide induction and by 59% for interleukin-1beta induction) at 24 hours.	Arginine	0-10	coagulation factor III, tissue factor	Homo sapiens	111-113
10760284-1	2000	To understand the relevance of p53 missense mutations in vivo, we generated a mouse containing an arg-to-his substitution at p53 amino acid 172, which corresponds to the R175H hot-spot mutation in human tumors by homologous recombination.	Arginine	98-101	transformation related protein 53, pseudogene	Mus musculus	125-128
10806445-1	2000	PURPOSE: Production of NO may be regulated by argininosuccinate synthetase and argininosuccinate lyase which recycle citrulline to arginine, and by arginase which hydrolyzes arginine to urea and ornithine.	Arginine	131-139	argininosuccinate lyase	Rattus norvegicus	79-102
10779015-0	2000	Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment.	Arginine	80-90	nitric oxide synthase 3, endothelial cell	Mus musculus	0-33
10779015-5	2000	After eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days), L-arginine amplified and sustained the hyperemia (38%) and increased absolute brain blood flow from 86 +/- 7 to 119 +/- 10 mL/100 g per minute.	Arginine	102-112	nitric oxide synthase 3, endothelial cell	Mus musculus	6-10
10779015-7	2000	Together, these findings suggest that eNOS activity is critical for blood flow augmentation during acute L-arginine infusion, and chronic eNOS upregulation combined with L-arginine administration provides a novel strategy to elevate cerebral blood flow in the normal and ischemic brain.	Arginine	105-115	nitric oxide synthase 3, endothelial cell	Mus musculus	38-42
10766452-8	2000	IAPP (10 microM) enhanced the inhibitory effect of somatostatin on insulin secretion induced by L-arginine or forskolin.	Arginine	96-106	islet amyloid polypeptide	Rattus norvegicus	0-4
10766452-9	2000	PTX pretreatment abolished the effects of somatostatin and IAPP on arginine-induced insulin secretion.	Arginine	67-75	islet amyloid polypeptide	Rattus norvegicus	59-63
10722752-5	2000	Generation of the full-length M(3)-MR-Arg(252)-Gln(490) i3 peptides containing the F312A mutation were also deficient in Gbetagamma binding and exhibited a reduced capacity for phosphorylation by GRK2.	Arginine	38-41	beta-adrenergic receptor kinase 1	Cricetulus griseus	196-200
10700017-10	2000	A clear protective effect was observed, however, in CA1 and CA3, in rats receiving both L-arginine plus 7-nitroindazole before KA.	Arginine	88-98	carbonic anhydrase 1	Rattus norvegicus	52-55
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Arginine	166-169	oxidized low density lipoprotein receptor 1	Bos taurus	24-29
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Arginine	166-169	oxidized low density lipoprotein receptor 1	Bos taurus	120-125
10712396-7	2000	Purification of soluble LOX-1 by high-performance liquid chromatography and N-terminal amino acid sequencing of soluble LOX-1 identified the 2 cleavage sites between Arg(86)-Ser(87) and Lys(89)-Ser(90), which were located in the membrane proximal extracellular domain of LOX-1.	Arginine	166-169	oxidized low density lipoprotein receptor 1	Bos taurus	120-125
10669798-6	2000	It cleaved the substrate, Boc-Arg-Val-Arg-Arg-MCA, between the dibasic sequence Arg-Arg, and needed a support of aminopeptidase B-like enzyme activity for the liberation of 7-amino-4-methylcoumarin.	Arginine	30-33	arginyl aminopeptidase	Rattus norvegicus	113-129
10669798-6	2000	It cleaved the substrate, Boc-Arg-Val-Arg-Arg-MCA, between the dibasic sequence Arg-Arg, and needed a support of aminopeptidase B-like enzyme activity for the liberation of 7-amino-4-methylcoumarin.	Arginine	38-41	arginyl aminopeptidase	Rattus norvegicus	113-129
10669798-6	2000	It cleaved the substrate, Boc-Arg-Val-Arg-Arg-MCA, between the dibasic sequence Arg-Arg, and needed a support of aminopeptidase B-like enzyme activity for the liberation of 7-amino-4-methylcoumarin.	Arginine	38-41	arginyl aminopeptidase	Rattus norvegicus	113-129
10669798-6	2000	It cleaved the substrate, Boc-Arg-Val-Arg-Arg-MCA, between the dibasic sequence Arg-Arg, and needed a support of aminopeptidase B-like enzyme activity for the liberation of 7-amino-4-methylcoumarin.	Arginine	38-41	arginyl aminopeptidase	Rattus norvegicus	113-129
10673221-5	2000	The Arg-51 in LTC4 synthase has been suggested to function as proton donor for the opening of the LTA4 epoxide.	Arginine	4-7	leukotriene C4 synthase	Homo sapiens	14-27
10735633-2	2000	The syndrome was associated with a novel KCNH2 missense mutation, G572R, causing the substitution of a glycine residue at position 572, at the end of the S5 transmembrane segment of the HERG K(+)-channel, with an arginine residue.	Arginine	213-221	potassium voltage-gated channel subfamily H member 2	Homo sapiens	41-46
10735633-2	2000	The syndrome was associated with a novel KCNH2 missense mutation, G572R, causing the substitution of a glycine residue at position 572, at the end of the S5 transmembrane segment of the HERG K(+)-channel, with an arginine residue.	Arginine	213-221	potassium voltage-gated channel subfamily H member 2	Homo sapiens	186-190
10735543-1	2000	BACKGROUND: Previous in vitro experiments have indicated that if the ninth codon of the hepatitis C virus (HCV) core gene is mutated from arginine to lysine, a short 16-kDa (P16) instead of a 21-kDa (P21) core protein will be produced.	Arginine	138-146	H3 histone pseudogene 16	Homo sapiens	200-203
10644716-0	2000	Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor.	Arginine	10-18	low density lipoprotein receptor	Homo sapiens	65-97
10644716-1	2000	The region of apolipoprotein E (apoE) that interacts directly with the low density lipoprotein (LDL) receptor lies in the vicinity of residues 136-150, where lysine and arginine residues are crucial for full binding activity.	Arginine	169-177	low density lipoprotein receptor	Homo sapiens	71-109
10644716-8	2000	Thus, the association of apoE with phospholipids allows Arg(172) to interact directly with the LDL receptor or with other residues in apoE to promote its receptor-active conformation.	Arginine	56-59	low density lipoprotein receptor	Homo sapiens	95-107
10615072-6	2000	Phosphorylation of H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH (BPDEtide), a specific substrate for PKG, measured the activity of cGMP-dependent protein kinase (PKG).	Arginine	19-24	protein kinase cGMP-dependent 1	Homo sapiens	113-116
10615072-6	2000	Phosphorylation of H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH (BPDEtide), a specific substrate for PKG, measured the activity of cGMP-dependent protein kinase (PKG).	Arginine	19-24	protein kinase cGMP-dependent 1	Homo sapiens	174-177
10619999-10	2000	Why the substitution by valine instead of arginine resulted only in a partial suppression of LPL secretion, remains to be investigated.	Arginine	42-50	lipoprotein lipase	Homo sapiens	93-96
10805420-6	2000	L-arginine addition to L-NNA treatment completely reversed plasma noradrenaline and ACE activity values.	Arginine	0-10	angiotensin I converting enzyme	Gallus gallus	84-87
10593939-2	1999	By using the C-terminal arginine-rich region of Arabidopsis U1-70K protein in the yeast two-hybrid system, we have identified an SC35-like (SR33) and a novel plant serine/arginine-rich (SR) protein (SR45) that interact with the plant U1-70K.	Arginine	24-32	U1 small nuclear ribonucleoprotein-70K	Arabidopsis thaliana	60-66
10593939-9	1999	These and our previous results suggest that the plant U1-70K interacts with at least four distinct members of the SR family including SR45 with its two arginine/serine-rich domains, and the interaction between the SR proteins and AFC2 is modulated by phosphorylation.	Arginine	152-160	U1 small nuclear ribonucleoprotein-70K	Arabidopsis thaliana	54-60
10600548-6	1999	The EGF-like domain of TR was highly conserved compared to EGF/NRG family growth factors with the exception of an arginine to histidine substitution at position 39 (Arg --&gt; His 39).	Arginine	165-168	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	23-25
10594405-9	1999	L-Arg did not affect postprandial pH and plasma hormones, but reversed L-NMMA-induced alterations in intragastric pH and in plasma gastrin and somatostatin levels.	Arginine	0-5	gastrin	Homo sapiens	131-138
10567393-0	1999	Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain.	Arginine	132-140	FA complementation group G	Homo sapiens	100-105
10567393-6	1999	By alanine mutagenesis, Arg(1), Arg(2), and Leu(8) but not Arg(3), Trp(5), and Glu(7) appeared to be critical for binding to FANCG.	Arginine	24-27	FA complementation group G	Homo sapiens	125-130
10567393-6	1999	By alanine mutagenesis, Arg(1), Arg(2), and Leu(8) but not Arg(3), Trp(5), and Glu(7) appeared to be critical for binding to FANCG.	Arginine	32-35	FA complementation group G	Homo sapiens	125-130
10567393-6	1999	By alanine mutagenesis, Arg(1), Arg(2), and Leu(8) but not Arg(3), Trp(5), and Glu(7) appeared to be critical for binding to FANCG.	Arginine	32-35	FA complementation group G	Homo sapiens	125-130
10562497-0	1999	Four consecutive arginine residues at positions 836-839 of EBV gp110 determine intracellular localization of gp110.	Arginine	17-25	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	63-68
10562497-0	1999	Four consecutive arginine residues at positions 836-839 of EBV gp110 determine intracellular localization of gp110.	Arginine	17-25	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	109-114
10562497-5	1999	Interestingly, there are four consecutive arginine residues (at positions 836-839 of gp110) in the C-terminal domain previously shown to be important for gp110"s intracellular localization.	Arginine	42-50	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	85-90
10562497-5	1999	Interestingly, there are four consecutive arginine residues (at positions 836-839 of gp110) in the C-terminal domain previously shown to be important for gp110"s intracellular localization.	Arginine	42-50	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	154-159
10562497-8	1999	Substitution of part of the four arginines changed the glycosylation profile and targeting of gp110.	Arginine	33-42	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	94-99
10562497-10	1999	These results suggest that not only the net charge but also the conformation of the four arginines are important for gp110"s processing and subcellular localization.	Arginine	89-98	ADRM1 26S proteasome ubiquitin receptor	Homo sapiens	117-122
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	95-98	serum/glucocorticoid regulated kinase family, member 3	Rattus norvegicus	28-32
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	103-106	serum/glucocorticoid regulated kinase family, member 3	Rattus norvegicus	28-32
10563629-6	1999	RESULTS: Maternal relatives harbor a G-to-A missense mutation, heteroplasmic in some patients, at nucleotide position 11778 of the mitochondrial ND4 gene of complex I that converts a highly conserved arginine to a histidine.	Arginine	200-208	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	145-148
10527945-8	1999	This indicates that RanGAP-stimulated GTP hydrolysis on Ran does not involve a catalytic arginine residue but requires certain charged residues of the LRR domain of the GAP for mediating the protein-protein interaction.	Arginine	89-97	Ran GTPase activating protein 1	Homo sapiens	20-26
10527945-8	1999	This indicates that RanGAP-stimulated GTP hydrolysis on Ran does not involve a catalytic arginine residue but requires certain charged residues of the LRR domain of the GAP for mediating the protein-protein interaction.	Arginine	89-97	RAN, member RAS oncogene family	Homo sapiens	20-23
10690305-12	1999	CONCLUSIONS: The data revealed that arginine at position 534 in the S4 region of HERG is indeed involved in voltage-dependence of channel activation as a voltage sensor.	Arginine	36-44	potassium voltage-gated channel subfamily H member 2	Homo sapiens	81-85
10559172-2	1999	CAR2, which encodes the arginine-degradative enzyme ornithine transaminase, is not nitrogen catabolite repression sensitive, but its expression can be modestly induced by the allantoin pathway inducer.	Arginine	24-32	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	0-4
10559172-3	1999	The dominant activators of CAR2 transcription have been thought to be the ArgR and Mcm1 factors, which mediate arginine-dependent induction.	Arginine	111-119	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	27-31
10559172-3	1999	The dominant activators of CAR2 transcription have been thought to be the ArgR and Mcm1 factors, which mediate arginine-dependent induction.	Arginine	111-119	transcription factor MCM1	Saccharomyces cerevisiae S288C	83-87
10502303-5	1999	The consensus sequence for substrate phosphorylation was determined to be RXXSXR, which was partially distinct from mammalian p70(S6K) in its requirement for an amino-terminal arginine.	Arginine	176-184	ribosomal protein S6 kinase B1	Homo sapiens	130-133
10545951-7	1999	The clinical profile of patients with the truncated NEUROD1 polypeptide is more severe than that of patients with the Arg 111 mutation.	Arginine	118-121	neuronal differentiation 1	Homo sapiens	52-59
10510312-7	1999	Reciprocal experiments have identified two arginine residues at positions 39 and 40 that are essential for AKAP79(31-52) peptide inhibition of PKCbetaII.	Arginine	43-51	phospholipase C, beta 2	Rattus norvegicus	143-152
10516295-2	1999	RNA editing of the codon that encodes the glutamine/arginine (Q/R) site in the second membrane domain (MD2) of glutamate receptor 5 (GluR5) and GluR6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single-channel conductances.	Arginine	52-60	lymphocyte antigen 96	Mus musculus	103-106
10473900-1	1999	The expression of two genes, coding for argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL), enzymes which synthesize arginine, was studied by Northern analysis in various tissues of fetal rats.	Arginine	135-143	argininosuccinate lyase	Rattus norvegicus	79-102
10473900-1	1999	The expression of two genes, coding for argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL), enzymes which synthesize arginine, was studied by Northern analysis in various tissues of fetal rats.	Arginine	135-143	argininosuccinate lyase	Rattus norvegicus	104-107
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Arginine	140-143	proprotein convertase subtilisin/kexin type 1	Homo sapiens	259-262
10493908-4	1999	Among the various peptidyl-[4-methylcoumarin 7-amide (MCA)] substrates tested, the one that was preferred the most by rPC4A was acetyl (Ac)-Arg-Lys-Lys-Arg-MCA, which is cleaved 9 times faster (as judged from V(max)/K(m) measurements) than the best furin and PC1 substrate, pGlu-Arg-Thr-Lys-Arg-MCA.	Arginine	152-155	proprotein convertase subtilisin/kexin type 1	Homo sapiens	259-262
10477705-6	1999	We also demonstrate PIR-A3 interaction with the endogenous FcepsilonRIgamma of the ANA-1 macrophage cell line, again in an Arg(632)-dependent manner.	Arginine	123-126	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	Mus musculus	20-26
2914904-2	1989	A membrane-bound neutral carboxypeptidase B-like enzyme was solubilized from human placental microvilli with 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate (CHAPS) and purified to homogeneity by ion-exchange chromatography and affinity chromatography on arginine-Sepharose.	Arginine	266-274	carboxypeptidase B1	Homo sapiens	25-43
3203741-3	1988	A molecular mass of 3297.4 Da was obtained by FAB mass spectrometry which corresponded exactly to GLP-1 7-36 NH2, providing evidence that amidation occurs at an arginine residue during the post-translational processing of GLP-1.	Arginine	161-169	glucagon	Rattus norvegicus	98-103
3203741-3	1988	A molecular mass of 3297.4 Da was obtained by FAB mass spectrometry which corresponded exactly to GLP-1 7-36 NH2, providing evidence that amidation occurs at an arginine residue during the post-translational processing of GLP-1.	Arginine	161-169	glucagon	Rattus norvegicus	222-227
3242600-1	1988	Previous studies have shown that murine macrophages immunostimulated with interferon gamma and Escherichia coli lipopolysaccharide synthesize NO2-, NO3-, and citrulline from L-arginine by oxidation of one of the two chemically equivalent guanido nitrogens.	Arginine	174-184	NBL1, DAN family BMP antagonist	Mus musculus	148-151
3242600-5	1988	Nitric oxide formation was dependent on the presence of L-arginine and NADPH and was inhibited by the NO2-/NO3- synthesis inhibitor NG-monomethyl-L-arginine.	Arginine	56-66	NBL1, DAN family BMP antagonist	Mus musculus	107-110
3242600-7	1988	The results show that nitric oxide is an intermediate in the L-arginine to NO2-, NO3-, and citrulline pathway.	Arginine	61-71	NBL1, DAN family BMP antagonist	Mus musculus	81-84
2464136-6	1988	Arginine residue 33, which has been conserved through vertebrate evolution, is a major antigenic contributor, since a large decrease in immunoreactivity, not accompanied by a significant change in conformation, was observed upon specific removal of this residue by carboxypeptidase B.	Arginine	0-8	carboxypeptidase B1	Homo sapiens	265-283
2902147-1	1988	We investigated the direct effects of physiological levels of epinephrine on the basal and arginine-stimulated secretion of insulin, glucagon, and somatostatin from the in situ pancreas in halothane-anaesthetized dogs.	Arginine	91-99	insulin	Canis lupus familiaris	124-131
10477705-8	1999	Our data are the first to show the potential of PIR-A3 to deliver activation signals to macrophages and establish its dependence on Arg(632).	Arginine	132-135	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	Mus musculus	48-54
11715462-0	1999	[The effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 in endothelial cells induced by lipopolysaccharide].	Arginine	16-26	C-C motif chemokine ligand 2	Homo sapiens	63-97
11715462-1	1999	OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs).	Arginine	37-47	C-C motif chemokine ligand 2	Homo sapiens	84-118
11715462-1	1999	OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs).	Arginine	37-47	C-C motif chemokine ligand 2	Homo sapiens	120-125
11715462-9	1999	The MCP-1 protein content in the EC-CM of the LPS + L-arginine group and the LPS + nimodipine group was significantly lower than that of the LPS group (P &lt; 0.01).	Arginine	52-62	C-C motif chemokine ligand 2	Homo sapiens	4-9
11715462-11	1999	CONCLUSION: L-arginine and nimodipine can markedly inhibit the expression of MCP-1 in ECs induced by LPS.	Arginine	12-22	C-C motif chemokine ligand 2	Homo sapiens	77-82
10430617-5	1999	The Arg(972) IRS-1 variant did not affect expression or function of endogenous IRS-2.	Arginine	4-7	insulin receptor substrate 1	Homo sapiens	13-18
10430617-11	1999	By contrast, RIN cells expressing Arg(972) IRS-1 exhibited a marked decrease in both glucose- and sulfonylurea-stimulated insulin secretion compared with RIN-WT.	Arginine	34-37	insulin receptor substrate 1	Homo sapiens	43-48
10430617-13	1999	More importantly, the results suggest that the common Arg(972) IRS-1 polymorphism may impair glucose-stimulated insulin secretion, thus contributing to the relative insulin deficiency observed in carriers of this variant.	Arginine	54-57	insulin receptor substrate 1	Homo sapiens	63-68
10604196-4	1999	Depletion of arginine, cystine and all essential amino acids leads to induction of insulin-like growth factor-binding protein-1 (IGFBP-1) mRNA and protein expression in a dose-dependent manner.	Arginine	13-21	insulin like growth factor binding protein 1	Homo sapiens	83-127
10604196-4	1999	Depletion of arginine, cystine and all essential amino acids leads to induction of insulin-like growth factor-binding protein-1 (IGFBP-1) mRNA and protein expression in a dose-dependent manner.	Arginine	13-21	insulin like growth factor binding protein 1	Homo sapiens	129-136
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Arginine	18-26	pleckstrin	Homo sapiens	53-56
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Arginine	18-26	pleckstrin	Homo sapiens	53-62
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	57-60
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	61-65
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	105-120
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	calcineurin like EF-hand protein 1	Homo sapiens	121-124
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	109-113
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	146-161
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	105-108
10391914-6	1999	Peptides matching amino acids 301-320 and 314-335 of the p47(phox) arginine/lysine-rich region block the p47(phox) SH3AB/p22(phox) C-terminal and p47(phox) SH3AB/p47(phox) C-terminal binding and inhibit NADPH oxidase activity in vitro.	Arginine	67-75	pleckstrin	Homo sapiens	109-113
10391914-9	1999	We conclude that the p47(phox) SH3A domain-binding site is blocked by an interaction between the p47(phox) SH3AB domains and the C-terminal arginine/lysine-rich region.	Arginine	140-148	pleckstrin	Homo sapiens	21-30
10391914-9	1999	We conclude that the p47(phox) SH3A domain-binding site is blocked by an interaction between the p47(phox) SH3AB domains and the C-terminal arginine/lysine-rich region.	Arginine	140-148	pleckstrin	Homo sapiens	97-106
10377064-1	1999	Ubiquitin cross-reactive protein (UCRP) is a 17-kDa protein that shows cross-reactivity with ubiquitin antisera and retains the carboxyl-terminal Leu-Arg-Gly-Gly amino acid sequence of ubiquitin that ligates to, and directs degradation of, cytosolic proteins.	Arginine	150-153	ISG15 ubiquitin like modifier	Bos taurus	0-32
10377064-1	1999	Ubiquitin cross-reactive protein (UCRP) is a 17-kDa protein that shows cross-reactivity with ubiquitin antisera and retains the carboxyl-terminal Leu-Arg-Gly-Gly amino acid sequence of ubiquitin that ligates to, and directs degradation of, cytosolic proteins.	Arginine	150-153	ISG15 ubiquitin like modifier	Bos taurus	34-38
10440133-0	1999	Overexpression of dominant negative mutant hepatocyte nuclear factor (HNF)-1alpha inhibits arginine-induced insulin secretion in MIN6 cells.	Arginine	91-99	HNF1 homeobox A	Mus musculus	43-81
10440133-9	1999	Suppression of HNF-1alpha in MIN6 cells severely impaired potentiation of insulin secretion by arginine, whereas glucose-stimulated and leucine-stimulated insulin secretion was intact.	Arginine	95-103	HNF1 homeobox A	Mus musculus	15-25
10385647-7	1999	Treatment with the NOS inhibitor NG-monomethyl L-arginine prevented HBP23 mRNA induction by LPS, which was reversed by an excess of L-arginine.	Arginine	47-57	peroxiredoxin 1	Rattus norvegicus	68-73
10362599-3	1999	The cytoplasmic loop (CL) and arginines of a COOH-terminal domain (CT1) of connexin32 (Cx32) were shown to determine CO2 sensitivity, and a gating mechanism involving CL-CT1 association-dissociation was proposed.	Arginine	30-39	gap junction protein beta 1 L homeolog	Xenopus laevis	75-85
10362599-3	1999	The cytoplasmic loop (CL) and arginines of a COOH-terminal domain (CT1) of connexin32 (Cx32) were shown to determine CO2 sensitivity, and a gating mechanism involving CL-CT1 association-dissociation was proposed.	Arginine	30-39	gap junction protein beta 1 L homeolog	Xenopus laevis	87-91
10357778-4	1999	DNA from normal tissue was also evaluated for polymorphisms in cytochrome P450 2C9 (CYP2C9) at two sites, codons 144 (Arg/Cys) and 359 (Ile/Leu), for glutathione S-transferase P1 (GSTP1) at codon 105 and for NAD(P)H:quinone oxidoreductase (NQO1) at codon 187 (Pro/Ser).	Arginine	118-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	63-82
10357778-4	1999	DNA from normal tissue was also evaluated for polymorphisms in cytochrome P450 2C9 (CYP2C9) at two sites, codons 144 (Arg/Cys) and 359 (Ile/Leu), for glutathione S-transferase P1 (GSTP1) at codon 105 and for NAD(P)H:quinone oxidoreductase (NQO1) at codon 187 (Pro/Ser).	Arginine	118-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	84-90
10370135-2	1999	It is generated from l-arginine by nitric oxide synthases (NOS), which come in three isoforms depending on the tissue of origin, namely inducible-NOS (iNOS in macrophages), endothelial-NOS (eNOS in endothelial cells) and neural-NOS (nNOS in neural cells).	Arginine	21-31	nitric oxide synthase 3, endothelial cell	Mus musculus	173-188
10336483-3	1999	In this study, we identify a CaM-KK from Caenorhabditis elegans, and comparison of its sequence with the mammalian CaM-KK alpha and beta shows a unique Arg-Pro (RP)-rich insert in their catalytic domains relative to other protein kinases.	Arginine	152-155	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	29-35
10336483-6	1999	Site-directed mutagenesis of three conserved Arg in the RP- domain of CaM-KK confirmed that these positive charges are important for CaM-KIV activation.	Arginine	45-48	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	70-76
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Arginine	228-236	interferon alpha inducible protein 27	Homo sapiens	4-7
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Arginine	228-236	cyclin dependent kinase inhibitor 1B	Homo sapiens	8-12
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Arginine	228-236	interferon alpha inducible protein 27	Homo sapiens	104-107
10318797-4	1999	The p27(Kip1) -ubiquitination activity was higher at the G1/S boundary than during the G0/G1 phase, and p27(Kip1) ubiquitination was reduced significantly when the lysine residues at positions 134, 153, and 165 were replaced by arginine, suggesting that these lysine residues are the targets for Ub conjugation.	Arginine	228-236	cyclin dependent kinase inhibitor 1B	Homo sapiens	108-112
10385247-7	1999	Mutations of threonine 100 and arginine 102 at the extracellular side of transmembrane II of the guinea-pig 5-HT1D receptor to the corresponding primate residues, isoleucine and histidine, respectively, enhanced its affinity for isochromans to that of the gorilla receptor, with little effects on its affinities for serotonin, sumatriptan and metergoline.	Arginine	31-39	5-hydroxytryptamine receptor 1D	Cavia porcellus	108-123
10212193-4	1999	The single amino acid substitution Trp111 --&gt; Arg in Fuc-TIII was sufficient to change the specificity of fucose transfer from H-type 1 to H-type 2 acceptors.	Arginine	49-52	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	56-64
10212193-8	1999	The acidic residue adjacent to the candidate amino acid Trp/Arg seems to modulate the relative type 1/type 2 acceptor specificity, and its presence is necessary for enzyme activity since its substitution by the corresponding amide inactivated both Fuc-TIII and Fuc-Tb enzymes.	Arginine	60-63	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	248-256
10080889-6	1999	Side-chain modifications and proteolysis demonstrated that Lys and Arg residues in the C-terminal region of alpha1LG4 are essential for heparin binding.	Arginine	67-70	adrenoceptor alpha 1D	Homo sapiens	108-117
3282899-3	1988	Immortalized cells multiply in chemically defined medium deficient in arginine with transferrin plus insulin, whereas EGF, insulin, and transferrin are obligatory requirements for fetal or newborn mouse hepatocyte multiplication in primary cultures.	Arginine	70-78	transferrin	Mus musculus	84-95
10051546-3	1999	A lysine residue in the third transmembrane domain of the CB2 receptor (K109), which is conserved between the CB1 and CB2 receptors, was mutated to alanine or arginine to determine the role of this charged amino acid in receptor function.	Arginine	159-167	cannabinoid receptor 2	Homo sapiens	58-61
2448300-7	1988	The sequence of the peptide, Ser-Arg-Arg-Pro-[32PO4]Ser-Arg-Ala-Thr, corresponds to residues 374-381 which are located in the heparin-binding fragment of vitronectin identified by Suzuki et al.	Arginine	33-36	vitronectin	Homo sapiens	154-165
2448300-7	1988	The sequence of the peptide, Ser-Arg-Arg-Pro-[32PO4]Ser-Arg-Ala-Thr, corresponds to residues 374-381 which are located in the heparin-binding fragment of vitronectin identified by Suzuki et al.	Arginine	37-40	vitronectin	Homo sapiens	154-165
2448300-7	1988	The sequence of the peptide, Ser-Arg-Arg-Pro-[32PO4]Ser-Arg-Ala-Thr, corresponds to residues 374-381 which are located in the heparin-binding fragment of vitronectin identified by Suzuki et al.	Arginine	37-40	vitronectin	Homo sapiens	154-165
10029535-8	1999	(2) In AspAT subgroup Ia, Arg292 recognizes the side chain carboxylate of the substrate; however, residue 292 of the enzyme in subgroup Ib is not Arg, and in place of Arg292, Lys109 forms a salt bridge with the side chain carboxylate.	Arginine	26-29	aspartate/prephenate aminotransferase	Thermus thermophilus HB8	7-12
9931337-4	1999	A homozygous substitution of arginine (R) at codon 90 by tryptophan (W) was identified in the CRX homeodomain of one of the probands who was nearly blind from birth.	Arginine	29-37	cone-rod homeobox	Homo sapiens	94-97
2446681-1	1988	An arginine-glycine-aspartic acid sequence (RGD in the single letter code for amino acids) is present in the cell attachment site of both vitronectin and fibronectin.	Arginine	3-11	vitronectin	Ovis aries	138-149
10636468-11	1999	The introduction of two arginines (R) at positions 28 and 31 respectively, in the helix disrupted the native tetrameric state of TPH.	Arginine	24-33	tryptophan 5-hydroxylase 1	Oryctolagus cuniculus	129-132
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Arginine	77-80	vitronectin	Homo sapiens	4-15
2466737-6	1988	The vitronectin receptor is involved in the adhesion of endothelial cells to Arg-Gly-Asp-containing immobilized proteins such as vitronectin, fibrinogen, and von Willebrand factor.	Arginine	77-80	vitronectin	Homo sapiens	129-140
9990288-12	1999	In total, these results firmly establish that a major p34cdc2 phosphorylation site on the ribonucleotide reductase R2 protein occurs near the N-terminal end at serine-20, which is found within the sequence Ser-Pro-Leu-Lys-Arg-Leu.	Arginine	222-225	cyclin dependent kinase 1	Homo sapiens	54-61
3169881-6	1988	1987) is at position 77 of the mature protein where Lyt-3a encodes serine and Lyt-3b encodes arginine.	Arginine	93-101	CD8 antigen, beta chain 1	Mus musculus	78-83
9923600-4	1999	Plasmin cleaves gp160 precisely at the C-terminal arginine residue of gp120, and the processing is effectively inhibited by an analogue peptide of the cleavage motif (RXK/RR) and by plasmin inhibitors.	Arginine	50-58	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	70-75
9886946-7	1999	Arginine-stimulated insulin and glucagon secretion were dose dependently increased by IAPP antiserum, IAPP-(8-37), and somatostatin antiserum, respectively.	Arginine	0-8	islet amyloid polypeptide	Rattus norvegicus	86-90
3317405-4	1987	The 84-residue mature rat MGP predicted from the cDNA sequence has an additional 5 residues at its C terminus (-Arg-Arg-Gly-Ala-Lys) not seen in the sequence of MGP isolated from bovine bone.	Arginine	112-115	matrix Gla protein	Rattus norvegicus	26-29
3317405-4	1987	The 84-residue mature rat MGP predicted from the cDNA sequence has an additional 5 residues at its C terminus (-Arg-Arg-Gly-Ala-Lys) not seen in the sequence of MGP isolated from bovine bone.	Arginine	116-119	matrix Gla protein	Rattus norvegicus	26-29
9886946-7	1999	Arginine-stimulated insulin and glucagon secretion were dose dependently increased by IAPP antiserum, IAPP-(8-37), and somatostatin antiserum, respectively.	Arginine	0-8	islet amyloid polypeptide	Rattus norvegicus	102-106
3672035-1	1987	The hydrophilic nonapeptide Ser-Asp-Ala-Arg-Glu-Asn-Ile-Gln-Arg, identical with residues 59-67 of human amyloid protein A (AA) and serum amyloid protein A (SAA), was covalently bound via its carboxyl-terminal end to the carrier-protein keyhole limpet haemocyanin.	Arginine	40-43	serum amyloid A1 cluster	Homo sapiens	156-159
9886946-8	1999	Arginine-stimulated somatostatin secretion was dose dependently potentiated by IAPP antiserum.	Arginine	0-8	islet amyloid polypeptide	Rattus norvegicus	79-83
9886946-10	1999	A combination of somatostatin antiserum with IAPP antiserum or IAPP-(8-37) further enhanced the arginine-stimulated insulin and glucagon secretion compared with effects when the blocking reagents were used individually.	Arginine	96-104	islet amyloid polypeptide	Rattus norvegicus	45-49
2443507-1	1987	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	vitronectin	Homo sapiens	164-175
9886946-10	1999	A combination of somatostatin antiserum with IAPP antiserum or IAPP-(8-37) further enhanced the arginine-stimulated insulin and glucagon secretion compared with effects when the blocking reagents were used individually.	Arginine	96-104	islet amyloid polypeptide	Rattus norvegicus	63-67
9887201-6	1999	Together with the enhanced expression of AI, IL-4 induced the expression of the cationic amino acid transporter MCAT-2 and increased L-arginine transport into the cells.	Arginine	133-143	interleukin 4	Mus musculus	45-49
3429445-1	1987	The nontransformed glucocorticoid receptor (GR) and an 88-kDa protein in rat liver cytosol were selectively adsorbed on protamine- and arginine-Sepharose.	Arginine	135-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-42
3429445-1	1987	The nontransformed glucocorticoid receptor (GR) and an 88-kDa protein in rat liver cytosol were selectively adsorbed on protamine- and arginine-Sepharose.	Arginine	135-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	44-46
10626902-7	1999	We find that, in addition to critical CD loop residues, other regions in both domain one and two contribute to MAdCAM-1/alpha4beta7 interactions, including a buried arginine residue in the F strand of domain one and several acidic residues in a highly extended DE ribbon in domain 2.	Arginine	165-173	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	111-131
10083741-0	1999	A Gln/Arg polymorphism at codon 349 of the hBUBR1 gene.	Arginine	6-9	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	43-49
3501427-2	1987	The intact C3a was used along with des-Arg-C3a, which is formed on cleavage of Arg-77 at the C terminal of C3a, and C3a Arg69, which is a 69-residue fragment produced on tryptic digestion of C3.	Arginine	39-42	complement C3	Homo sapiens	43-46
3501427-2	1987	The intact C3a was used along with des-Arg-C3a, which is formed on cleavage of Arg-77 at the C terminal of C3a, and C3a Arg69, which is a 69-residue fragment produced on tryptic digestion of C3.	Arginine	39-42	complement C3	Homo sapiens	43-46
3501427-2	1987	The intact C3a was used along with des-Arg-C3a, which is formed on cleavage of Arg-77 at the C terminal of C3a, and C3a Arg69, which is a 69-residue fragment produced on tryptic digestion of C3.	Arginine	39-42	complement C3	Homo sapiens	43-46
10083741-1	1999	We found a glutamine/arginine polymorphism at codon 349 of the hBUBR1 gene, encoding a protein kinase required for spindle assembly checkpoint function.	Arginine	21-29	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	63-69
3501427-5	1987	It has been concluded that removal of Arg-77, which is essential for expression of the biological activity of C3a, does not induce any significant change in the solution conformation of the C3a molecule.	Arginine	38-41	complement C3	Homo sapiens	110-113
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	122-125	coagulation factor V	Homo sapiens	0-20
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	131-134	coagulation factor V	Homo sapiens	0-20
3302105-7	1987	The N-terminal amino acid sequence of CSF gamma-Aogen was Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-Leu-Leu-Val-Tyr-Ser-Lys-Ser-Ser-(X)-Glu- .	Arginine	62-65	colony stimulating factor 2	Canis lupus familiaris	38-41
10097286-1	1999	Coagulation factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545.	Arginine	131-134	coagulation factor V	Homo sapiens	0-20
10097286-11	1999	This study further shows that APC converts coagulation factor V into a member of the anticoagulant pathway by cleaving factor V in the A2 domain at Arg 506.	Arginine	148-151	coagulation factor V	Homo sapiens	43-63
11601009-1	1999	OBJECTIVES: To explore the suppressive effects of a murine genomic p53 minigene containing an Arg--&gt;Leu substitution at its encoding amino acid 172 on biological behaviors of human carcinoma cell and evaluate its potential application in cancer gene therapy.	Arginine	94-97	transformation related protein 53, pseudogene	Mus musculus	67-70
3655744-15	1987	Between the E2 and E1 genes, there is a stretch of seven amino acids, five of which are arginines, which may serve as cleavage sites for a trypsin-like protease.	Arginine	88-97	cystatin 12, pseudogene	Homo sapiens	12-21
2442758-2	1987	This complex can be isolated in pure form from an affinity matrix consisting of an Arg-Gly-Asp-containing heptapeptide and is specifically immunoprecipitated with monoclonal antibodies (mAbs) directed against the vitronectin receptor of human melanoma cells.	Arginine	83-86	vitronectin	Homo sapiens	213-224
9820825-2	1998	Using N-terminal peptide sequencing, matrix-assisted laser desorption ionization-time-of-flight MS and molecular modelling, we identified the three initial sites of proteolysis in Rab5 as Arg-4, Arg-81 and Arg-197.	Arginine	188-191	RAB5A, member RAS oncogene family	Homo sapiens	180-184
3318115-6	1987	Cathepsin B split off the C-terminal dipeptide in synthetic substrates Leu-Trp-Met-Arg-Phe-Ala and Trp-Met-Arg-Phe-Ala but not in Met-Arg-Phe-Ala.	Arginine	83-86	cathepsin B	Homo sapiens	0-11
9820825-2	1998	Using N-terminal peptide sequencing, matrix-assisted laser desorption ionization-time-of-flight MS and molecular modelling, we identified the three initial sites of proteolysis in Rab5 as Arg-4, Arg-81 and Arg-197.	Arginine	195-198	RAB5A, member RAS oncogene family	Homo sapiens	180-184
9820825-2	1998	Using N-terminal peptide sequencing, matrix-assisted laser desorption ionization-time-of-flight MS and molecular modelling, we identified the three initial sites of proteolysis in Rab5 as Arg-4, Arg-81 and Arg-197.	Arginine	195-198	RAB5A, member RAS oncogene family	Homo sapiens	180-184
3609029-4	1987	The main characteristic of this protein kinase is that it is arginine-specific.	Arginine	61-69	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	32-46
9820825-3	1998	Arg-4 and Arg-81 lie within regions previously implicated in Rab5 endocytic function, and Arg-197 lies in a region involved in membrane targeting.	Arginine	0-3	RAB5A, member RAS oncogene family	Homo sapiens	61-65
9820825-5	1998	Homology modelling studies on Rab5 indicate that the Arg-81 side chain is buried in the Rab5 GTP conformation, but is solvent-accessible in the GDP conformation, explaining the dependence of proteolysis on nucleotides.	Arginine	53-56	RAB5A, member RAS oncogene family	Homo sapiens	30-34
9820825-5	1998	Homology modelling studies on Rab5 indicate that the Arg-81 side chain is buried in the Rab5 GTP conformation, but is solvent-accessible in the GDP conformation, explaining the dependence of proteolysis on nucleotides.	Arginine	53-56	RAB5A, member RAS oncogene family	Homo sapiens	88-92
9820825-7	1998	The Rab4 cleavage sites corresponded to Arg-81 and Pro-87 of Rab5, and taken together with the finding that Rab5 was not cleaved at Arg-91 this analysis defines an eight-residue surface-exposed conformationally variable region lying in the centre of Switch II.	Arginine	40-43	RAB5A, member RAS oncogene family	Homo sapiens	61-65
2440809-11	1987	The binding to group G streptococci, S. aureus, and E. coli is mediated in part through a domain in the S protein containing the sequence Arg-Gly-Asp, whereas a different site is responsible for the binding to group A and C streptococci.	Arginine	138-141	vitronectin	Homo sapiens	104-113
9891840-0	1998	The carboxyl-terminal fragment of osteopontin suppresses arginine-glycine-asparatic acid-dependent cell adhesion.	Arginine	57-65	secreted phosphoprotein 1	Homo sapiens	34-45
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Arginine	131-134	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
9873696-0	1998	Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.	Arginine	29-37	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	102-116
2440106-3	1987	This clone encodes a 60-kilodalton protein that differs from chicken or human pp60c-src primarily in having six extra amino acids (Arg-Lys-Val-Asp-Val-Arg) within the NH2-terminal 16 kilodaltons of the molecule.	Arginine	151-154	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	78-87
3038106-2	1987	Analysis using synthetic 20-mer oligonucleotide probes revealed a point mutation from G to C at the first letter of codon 13 of the N-ras gene resulting in the substitution of arginine for glycine.	Arginine	176-184	NRAS proto-oncogene, GTPase	Homo sapiens	132-137
9873696-1	1998	In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics.	Arginine	142-150	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-90
9795208-7	1998	Site-directed mutagenesis of the fungal Alg2 and determination of their phenotypes in the yeast alg2-1 mutant showed that a mutation at 368Gly (equivalent to 377Gly of yeast Alg2) to Arg resulted in generation of a ts enzyme.	Arginine	183-186	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	40-44
9795208-7	1998	Site-directed mutagenesis of the fungal Alg2 and determination of their phenotypes in the yeast alg2-1 mutant showed that a mutation at 368Gly (equivalent to 377Gly of yeast Alg2) to Arg resulted in generation of a ts enzyme.	Arginine	183-186	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	96-100
3478308-5	1987	The formation of C3a des arg with PAN was less than with either CC or PC.	Arginine	25-28	complement C3	Homo sapiens	17-20
9795208-7	1998	Site-directed mutagenesis of the fungal Alg2 and determination of their phenotypes in the yeast alg2-1 mutant showed that a mutation at 368Gly (equivalent to 377Gly of yeast Alg2) to Arg resulted in generation of a ts enzyme.	Arginine	183-186	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	174-178
9778344-5	1998	The epsilon and eta nitrogens of the guanidinium side chain of Arg-39" from a neighboring dimer interact respectively with the C-2 carbonyl oxygen and one C-1 carboxylate oxygen of the adduct while the side chain of Arg-61" from the same dimer as the modified Pro-1 interacts with the C-1 carboxylate group in a bidentate fashion.	Arginine	63-66	lamin A/C	Homo sapiens	260-265
3626294-3	1987	Reuse of cuprophan dialyzers significantly attenuated the fall in leukocyte counts and the rise in C3a des Arg seen during first use dialysis.	Arginine	107-110	complement C3	Homo sapiens	99-102
3626294-9	1987	Percentual changes in leukocyte counts and C3a des Arg concentration on one hand, and in paO2, DLCO and KCO on the other were significantly correlated to each other.	Arginine	51-54	complement C3	Homo sapiens	43-46
9778344-5	1998	The epsilon and eta nitrogens of the guanidinium side chain of Arg-39" from a neighboring dimer interact respectively with the C-2 carbonyl oxygen and one C-1 carboxylate oxygen of the adduct while the side chain of Arg-61" from the same dimer as the modified Pro-1 interacts with the C-1 carboxylate group in a bidentate fashion.	Arginine	216-219	lamin A/C	Homo sapiens	260-265
9778344-7	1998	These interactions coupled with the observation that 2-oxo-3-butynoate is a more potent irreversible inhibitor of 4-oxalocrotonate tautomerase than is 2-OP suggest that Arg-39" and the ordered water molecule polarize the carbonyl group of 2-OP which facilitates a Michael reaction between Pro-1 and the acetylene compound.	Arginine	169-172	lamin A/C	Homo sapiens	289-294
9756909-7	1998	The PML mutant with Lys to Arg substitutions in all three sites is expressed normally, but cannot be sentrinized.	Arginine	27-30	PML nuclear body scaffold	Homo sapiens	4-7
2440473-6	1987	Only the Arg-20 NH exchange rate shows significant differences between trypsinogen-BPTI and trypsinogen-Ile-Val-BPTI and between porcine and bovine trypsin-BPTI.	Arginine	9-12	spleen trypsin inhibitor I	Bos taurus	83-87
2440473-6	1987	Only the Arg-20 NH exchange rate shows significant differences between trypsinogen-BPTI and trypsinogen-Ile-Val-BPTI and between porcine and bovine trypsin-BPTI.	Arginine	9-12	spleen trypsin inhibitor I	Bos taurus	112-116
9827059-6	1998	Alkaline phosphatase, alanine aminotransferase and gamma-glutamyl transpeptidase serum enzyme activities increased (P &lt; 0.05) by BDL, again L-arginine treatment partially, but significantly, prevented the elevation in these three markers of liver damage.	Arginine	143-153	gamma-glutamyltransferase 1	Rattus norvegicus	51-80
2440473-6	1987	Only the Arg-20 NH exchange rate shows significant differences between trypsinogen-BPTI and trypsinogen-Ile-Val-BPTI and between porcine and bovine trypsin-BPTI.	Arginine	9-12	spleen trypsin inhibitor I	Bos taurus	112-116
3584243-10	1987	Clustering was also induced by the addition of the GPIIb-IIIa-binding domains of fibrinogen, namely the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	117-120	integrin subunit alpha 2b	Homo sapiens	51-56
9733769-3	1998	Three IGF-I arginine side chains were identified by NMR to participate in IGFBP-1 binding.	Arginine	12-20	insulin like growth factor binding protein 1	Homo sapiens	74-81
3104208-4	1987	Gonococcal type 1 IgA1 protease was produced primarily by N. gonorrhoeae strains which require arginine, hypoxanthine, and uracil (AHU) and which belong to the protein IA-1 or IA-2 serovar.	Arginine	95-103	immunoglobulin heavy constant alpha 1	Homo sapiens	18-22
9712856-1	1998	The two mannose 6-phosphate (Man-6-P) binding sites of the insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/MPR) have been localized to domains 1-3 and 7-9, and studies have shown that Arg435 in domain 3 and Arg 1334 in domain 9 are essential for Man-6-P binding.	Arginine	203-206	insulin like growth factor 2	Homo sapiens	119-125
3103680-0	1987	Functional role of proteolytic cleavage at arginine-275 of human tissue plasminogen activator as assessed by site-directed mutagenesis.	Arginine	43-51	chromosome 20 open reading frame 181	Homo sapiens	65-93
9712897-7	1998	Data from both sets of fluorogenic substrates supported the contribution of a P4 Arg to PC2 preference.	Arginine	81-84	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	88-91
2887399-1	1987	The conversion of C3 and B in the mixture of C3, B, D and Mg++ ions was inhibited in the presence of arginine and lysine, but not in the presence of glutamic acid and aspartic acid among other amino acids.	Arginine	101-109	complement C3	Homo sapiens	18-26
20501177-8	1987	After digestion with trypsin and carboxypeptidase B, met-enkephalin immunoreactivity appeared in fractions probably containing met-enkephalin-arg-6-phe-7, met-enkephalin-arg-6-gly-7-leu-8 and peptide E.	Arginine	142-145	carboxypeptidase B1	Bos taurus	33-51
2430295-1	1986	Cells adhere to vitronectin substrates through a cell surface receptor that recognizes an Arg-Gly-Asp sequence in vitronectin.	Arginine	90-93	vitronectin	Homo sapiens	16-27
2430295-1	1986	Cells adhere to vitronectin substrates through a cell surface receptor that recognizes an Arg-Gly-Asp sequence in vitronectin.	Arginine	90-93	vitronectin	Homo sapiens	114-125
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	75-78	insulin like growth factor 1 receptor	Homo sapiens	123-137
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	83-86	insulin like growth factor 1 receptor	Homo sapiens	123-137
2877871-4	1986	In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg-Lys-Arg-Arg sequence at position 707 of the IGF-I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.	Arginine	83-86	insulin like growth factor 1 receptor	Homo sapiens	123-137
2937785-6	1986	Thrombin cleaves two peptide bonds in this part of protein S, first at arginine 70 and then at arginine 52.	Arginine	71-79	coagulation factor II, thrombin	Bos taurus	0-8
2937785-6	1986	Thrombin cleaves two peptide bonds in this part of protein S, first at arginine 70 and then at arginine 52.	Arginine	95-103	coagulation factor II, thrombin	Bos taurus	0-8
2937786-1	1986	Thrombin cleaves protein S at arginine residues 52 and 70 resulting in loss of cofactor activity and reduced Ca2+ ion binding.	Arginine	30-38	coagulation factor II, thrombin	Bos taurus	0-8
3953797-9	1986	Since arginase catalyzes the conversion of arginine to orthithine, thus ensuring the availability of this substrate for ornithine decarboxylase activity, these results indicate a disturbance of polyamine metabolism in mutant enterocytes with a consequent delay in postnatal differentiation and proliferation.	Arginine	43-51	ornithine decarboxylase, structural 1	Mus musculus	120-143
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	56-59	histidine rich glycoprotein	Homo sapiens	180-183
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	124-132	histidine rich glycoprotein	Homo sapiens	180-183
3000827-2	1986	The amino acid residue at the position corresponding to Arg-47 of AT III that is essential for the heparin-binding was also arginine (Arg 23 and 78) in the homologous sequences of HRG.	Arginine	134-137	histidine rich glycoprotein	Homo sapiens	180-183
3089951-0	1986	Inhibition by lysine and arginine of the conversion of C3 and B in the serum and a purified system.	Arginine	25-33	complement C3	Homo sapiens	55-63
3089951-7	1986	The addition of arginine and lysine resulted in the inhibition of the conversion of C3 and B in the serum at elevated temperature.	Arginine	16-24	complement C3	Homo sapiens	84-92
3089951-9	1986	In the purified system, only arginine and lysine prevented the conversion of C3 and B, when C3, B and D were incubated in the presence of Mg++ and amino-acids.	Arginine	29-37	complement C3	Homo sapiens	77-85
3089951-9	1986	In the purified system, only arginine and lysine prevented the conversion of C3 and B, when C3, B and D were incubated in the presence of Mg++ and amino-acids.	Arginine	29-37	complement C3	Homo sapiens	92-103
3089951-10	1986	Since lysine and arginine did not inhibit the enzymatic activity of D, these data suggest that arginine and lysine prevent the interaction of C3 and B in the serum at elevated temperatures.	Arginine	17-25	complement C3	Homo sapiens	142-150
3089951-10	1986	Since lysine and arginine did not inhibit the enzymatic activity of D, these data suggest that arginine and lysine prevent the interaction of C3 and B in the serum at elevated temperatures.	Arginine	95-103	complement C3	Homo sapiens	142-150
3530833-0	1986	Enzymatic reduction of phenylglyoxal and 2,3-butanedione, two commonly used arginine-modifying reagents, by the ketoacyl reductase domain of fatty acid synthase.	Arginine	76-84	fatty acid synthase	Homo sapiens	141-160
3161731-10	1985	The amino acid compositions of GP Ib beta and GP IX were similar but showed marked differences in the levels of glutamic acid, alanine, histidine and arginine.	Arginine	150-158	glycoprotein Ib platelet subunit beta	Homo sapiens	31-41
3155697-1	1985	Antithrombin is a protease inhibitor that neutralizes the activity of the serine proteases of the coagulation cascade, such as factors IXa, Xa, XIa, XIIa, and thrombin by forming a 1:1 stoichiometric complex between enzyme and inhibitor via a reactive site (arginine)-active center (serine interaction).	Arginine	258-266	coagulation factor II, thrombin	Bos taurus	4-12
3925401-1	1985	Chemical modification studies on homogeneous bovine lens aldose reductase using diethylpyrocarbonate, phenylglyoxal, butanedione, N-ethylmaleimide and p-chloromercuribenzoate indicate that histidine and arginine residues located at or near the nucleotide binding site may be important in binding or orientation of the NADPH, and that NADPH oxidation with glucose requires protein thiol.	Arginine	203-211	aldose reductase	Bos taurus	57-73
6238036-3	1984	HMG 17 is phosphorylated predominantly in a single seryl residue, Ser 24 in the sequence Gln-Arg-Arg-Ser 24-Ala-Arg-Leu-Ser 28-Ala-Lys, with the second seryl moiety, Ser 28, modified to a markedly lesser degree.	Arginine	93-96	high mobility group nucleosomal binding domain 2	Homo sapiens	0-6
6238036-3	1984	HMG 17 is phosphorylated predominantly in a single seryl residue, Ser 24 in the sequence Gln-Arg-Arg-Ser 24-Ala-Arg-Leu-Ser 28-Ala-Lys, with the second seryl moiety, Ser 28, modified to a markedly lesser degree.	Arginine	97-100	high mobility group nucleosomal binding domain 2	Homo sapiens	0-6
6238036-3	1984	HMG 17 is phosphorylated predominantly in a single seryl residue, Ser 24 in the sequence Gln-Arg-Arg-Ser 24-Ala-Arg-Leu-Ser 28-Ala-Lys, with the second seryl moiety, Ser 28, modified to a markedly lesser degree.	Arginine	97-100	high mobility group nucleosomal binding domain 2	Homo sapiens	0-6
6434531-9	1984	[3H] GEMSA binding activity is found only in fractions containing enkephalin convertase during enzyme purification from bovine pituitary by L-arginine affinity chromatography.	Arginine	140-150	carboxypeptidase E	Bos taurus	66-87
6149574-6	1984	Examination of the amino acid sequences of C4a, and comparison with those of the homologous molecules C3a and C5a, shows that there is a marked difference in the distribution of basic residues near the C-terminal arginine residue which is the site of action of C1s.	Arginine	213-221	complement C3	Homo sapiens	102-105
6395900-5	1984	Cathepsin H isoenzymes hydrolyzed Arg-NNap and BANA, were totally inhibited by 1 mM p-CMB and only to 60% by 5.10(-5) M leupeptin.	Arginine	34-37	cathepsin H	Rattus norvegicus	0-11
6148165-0	1984	Arginine infusion increases peripheral plasma somatostatin in man.	Arginine	0-8	somatostatin	Homo sapiens	46-58
6198465-1	1984	Rabbit myelin basic protein (BP) contains several Arg-X bonds with differing susceptibilities to thrombic cleavage as measured by the yields of the various cleavage products obtained under three different conditions.	Arginine	50-53	myelin basic protein	Oryctolagus cuniculus	7-27
6198465-7	1984	The susceptibilities to cleavage of the Arg-X bonds in the BP can be explained with varying degrees of success in terms of the known specificity of thrombin.	Arginine	40-43	prothrombin	Oryctolagus cuniculus	148-156
6691968-4	1984	Examination of the potency of thrombin inhibition by arginine derivatives related to MQPA in structure suggested the presence of a specific binding site for the carboxamide portion (C-terminal side).	Arginine	53-61	coagulation factor II, thrombin	Bos taurus	30-38
6325477-3	1984	Since the Ca2+-activated proteinase is very likely to be a trypsin-like enzyme, with a preference for arginyl and lysyl peptide bonds, the results indicate that the arginine residues of the amino-terminal polypeptide of vimentin and desmin are highly essential for filament assembly but largely dispensable for the binding of both proteins to nucleic acids.	Arginine	165-173	vimentin	Mus musculus	220-228
6325477-6	1984	Thus, the binding of vimentin to nucleic acids appears to be based on two components: a non-specific electrostatic interaction mediated by the positively charged arginine residues of the amino-terminal polypeptide that is insensitive to denaturation by urea, and a specific interaction that is sensitive to denaturation by urea.	Arginine	162-170	vimentin	Mus musculus	21-29
6582486-7	1984	One base mutation, C leads to T, in the 5" terminal position of the arginine-47 genetic codon (CGT) is probably responsible for this substitution.	Arginine	68-76	UDP glycosyltransferase 8	Homo sapiens	95-98
6316150-3	1983	There is a single, highly complementary position for O-2 to bind to both the Cu(II) and activity-important Arg 141 with correct geometry; two water molecules form a ghost of the superoxide in this position.	Arginine	107-110	immunoglobulin kappa variable 1D-39	Homo sapiens	53-56
6194549-7	1983	It is suggested that faster rate of release of O2 from Hb B may be due to its having lysine at position HCl in the beta-chain whereas the other haemoglobins have arginine.	Arginine	162-170	hemoglobin subunit beta	Ovis aries	55-59
6134596-0	1983	Somatostatin-28 and somatostatin-14 suppression of arginine-, insulin-, and TRH-stimulated GH and PRL secretion in man.	Arginine	51-59	somatostatin	Homo sapiens	20-35
6134596-4	1983	Arginine (0.5 g/kg) infused from 30 to 60 min induced an increase in GH secretion in all subjects and this increase was completely abolished in these same subjects when infused with SS-14 and SS-28.	Arginine	0-8	somatostatin	Homo sapiens	182-187
6134596-4	1983	Arginine (0.5 g/kg) infused from 30 to 60 min induced an increase in GH secretion in all subjects and this increase was completely abolished in these same subjects when infused with SS-14 and SS-28.	Arginine	0-8	somatostatin	Homo sapiens	192-197
6134596-5	1983	Arginine-induced hyperglycaemia was significantly greater during infusion of SS-14 and further enhanced by infusion of SS-28.	Arginine	0-8	somatostatin	Homo sapiens	77-82
6134596-5	1983	Arginine-induced hyperglycaemia was significantly greater during infusion of SS-14 and further enhanced by infusion of SS-28.	Arginine	0-8	somatostatin	Homo sapiens	119-124
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Arginine	376-379	neurotensin	Bos taurus	41-52
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Arginine	376-379	neurotensin	Bos taurus	54-56
7171553-2	1982	13C NMR titration data were obtained for all titrating groups except arginine residues in BPTI at nearly constant ionic strength in 0.1 M NaCl, at 41 degrees C. The chemical shifts of 46 resonances were found to be sensitive to pH.	Arginine	69-77	spleen trypsin inhibitor I	Bos taurus	90-94
9685386-4	1998	PIR1 also contains two stretches of arginine-rich sequences.	Arginine	36-44	dual specificity phosphatase 11	Homo sapiens	0-4
6286669-5	1982	The site of insulin-directed phosphorylation of ATP-citrate lyase (Thr-Ala-Ser(32P)-Phe-Ser-Glu-Ser-Arg) is the same as that directed by glucagon, and, in turn, identical with that phosphorylated by the cAMP-dependent protein kinase in vitro.	Arginine	100-103	ATP citrate lyase	Homo sapiens	48-65
9685421-0	1998	A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.	Arginine	9-17	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	43-49
6818840-4	1982	L-lysine (0.09 M) in hypotonic NaCl did not inhibit the water diuresis or cause any apparent AVP release, whereas the corresponding L-arginine infusions caused inhibition of the water diuresis and increase in AVP excretion of approximately the same magnitudes and time courses as the control infusions.	Arginine	132-142	vasopressin-neurophysin 2-copeptin	Capra hircus	209-212
9685421-5	1998	It has been clearly documented that the arginine/serine domain of ASF/SF2 is responsible for binding to the U1 70k protein.	Arginine	40-48	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	108-114
9685421-9	1998	Inspection of the sequence of the Arg248 to Asp270 region suggested this as an arginine/serine-like domain in U1 70k protein, and the data presented in this manuscript strongly support this view.	Arginine	79-87	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	110-116
9685421-10	1998	Inspection of the human U1 70k protein sequence, comparison with homologues in other animal species, and mutational analysis indicated the importance of the sequence Arg-Arg-Arg-Ser-Arg-Ser-Arg-Asp, which is found repeated twice in the region from Arg248 to Asp270 in the human protein.	Arginine	166-169	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	24-30
7142117-14	1982	The cleavage sites of bovine prothrombin for this enzyme were the same Arg-Thr and Arg-Ile linkages as those for Factor Xa, resulting in the formation of alpha-thrombin.	Arginine	71-74	coagulation factor II, thrombin	Bos taurus	32-40
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Arginine	18-21	general transcription factor 3A L homeolog	Xenopus laevis	68-93
7142117-14	1982	The cleavage sites of bovine prothrombin for this enzyme were the same Arg-Thr and Arg-Ile linkages as those for Factor Xa, resulting in the formation of alpha-thrombin.	Arginine	83-86	coagulation factor II, thrombin	Bos taurus	32-40
6977539-5	1982	NH2-terminal sequence analyses of the isolated modified inhibitor formed by Factor Xa showed that a single Arg-Ser bond in the COOH-terminal end of the inhibitor had been cleaved.	Arginine	107-110	coagulation factor X	Homo sapiens	76-85
9655916-1	1998	Basic amino acids Arg, Lys, and His in the Cys2His2 zinc fingers of transcription factor IIIA (TFIIIA) potentially have important roles in factor binding to the extended internal control region (ICR) of the 5S ribosomal gene.	Arginine	18-21	general transcription factor 3A L homeolog	Xenopus laevis	95-101
9655916-6	1998	Therefore, Arg-62 is individually required for TFIIIA binding over the entire ICR whereas His-58 is not.	Arginine	11-14	general transcription factor 3A L homeolog	Xenopus laevis	47-53
9679654-3	1998	rRAG-1 DNA binding activity was found to reside within a novel amino-terminal arginine-rich (RR) domain with partial homology to a variety of nucleic acid binding domains.	Arginine	78-86	recombination activating 1	Rattus norvegicus	0-6
7074053-4	1982	During the course of chymotrypsin studies, it was demonstrated that bovine neurophysin II behaves as a transient competitive inhibitor of chymotrypsin; for neurophysin-peptide complexes, Ki congruent to 8 x 10(-6) M. This inhibition is dependent on neurophysin conformation and is relieved by the anomalous preferential splitting by chymotrypsin of Arg-Arg and Phe-Pro bonds near the carboxyl terminus of neurophysin II.	Arginine	349-352	arginine vasopressin	Bos taurus	75-89
7074053-4	1982	During the course of chymotrypsin studies, it was demonstrated that bovine neurophysin II behaves as a transient competitive inhibitor of chymotrypsin; for neurophysin-peptide complexes, Ki congruent to 8 x 10(-6) M. This inhibition is dependent on neurophysin conformation and is relieved by the anomalous preferential splitting by chymotrypsin of Arg-Arg and Phe-Pro bonds near the carboxyl terminus of neurophysin II.	Arginine	353-356	arginine vasopressin	Bos taurus	75-89
6978710-24	1981	The specificity of C3bINA is for an Arg--Xaa peptide bond.	Arginine	36-39	complement factor I	Homo sapiens	19-25
9624108-4	1998	In the present study we demonstrate that agmatine, a metabolite of arginine via arginine decarboxylase (an arginine pathway distinct from that of the classical polyamines), also serves the dual regulatory functions of suppressing polyamine biosynthesis and cellular polyamine uptake through induction of antizyme.	Arginine	67-75	antizyme inhibitor 2	Homo sapiens	80-102
7315956-1	1981	Cats given a single arginine-free meal have been reported to develop severe hyperammonemia, attributed to impaired function of ornithine aminotransferase (OAT).	Arginine	20-28	ornithine aminotransferase	Felis catus	127-153
9717296-4	1998	Plasmin binding was prevented, in a concentration-dependent manner, by the amino acids lysine, arginine and epsilon-aminocaproic acid.	Arginine	95-103	plasminogen	Bos taurus	0-7
6109991-2	1981	The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS).	Arginine	81-89	somatostatin	Homo sapiens	56-68
9593777-7	1998	In summary, a null mutation in the HNF-1alpha gene in homozygous mice leads to diabetes due to alterations in the pathways that regulate beta cell responses to secretagogues including glucose and arginine.	Arginine	196-204	HNF1 homeobox A	Mus musculus	35-45
7014204-5	1980	The perifusion experiments demonstrated that motilin release from human duodenal mucosa into the perfusate was stimulated markedly by low pH and 15 mM taurocholate, but not affected by the perifusion of 20 mM glucose, 20 mM arginine, 100 mU/l insulin or 30 nM glucagon.	Arginine	224-232	motilin	Homo sapiens	45-52
6968751-9	1980	Thus, the hydrophobic side chains of leucine-73 and leucine-75 and the guanidinium group of arginine-77 are important for the contractile activity of the active site COOH-terminal pentapeptide of human C3a anaphylatoxin.	Arginine	92-100	complement C3	Homo sapiens	202-205
7305911-3	1980	This component was identified as pig albumin by the following comparisons with authentic pig serum albumin: (a) co-migration when analysed by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis under reducing and non-reducing conditions; (b) identical isoelectric points; (c) similar "fingerprints" of arginine-containing tryptic peptides; (d) reactivity with anti-(pig albumin) serum.	Arginine	309-317	albumin	Sus scrofa	37-44
7410435-6	1980	similar changes are found in carboxypeptidase B-digested hemoglobin Ao where the COOH-terminal arginine is removed by enzymatic digestion.	Arginine	95-103	carboxypeptidase B1	Homo sapiens	29-47
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	118-126	carboxypeptidase B1	Homo sapiens	62-80
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	160-168	carboxypeptidase B1	Homo sapiens	62-80
6448971-3	1980	Comparative experiences with the same substrate revealed that carboxypeptidase B liberated exclusively the C-terminal arginine, plasmin exclusively peptides of arginine, and trypsin, besides arginine peptides, minutes quantities of free arginine.	Arginine	160-168	carboxypeptidase B1	Homo sapiens	62-80
117793-0	1979	Chemical characterization of a new Japanese variant of carbonic anhydrase I, CA INagasaki 1 (76 arg leads to gln).	Arginine	96-99	carbonic anhydrase 1	Homo sapiens	55-75
39113-1	1979	Glutamine synthetase in Bacillus subtilis 168 was repressed to a greater extent by L-glutamine or L-arginine than by ammonia when each was used as sole nitrogen source.	Arginine	98-108	glutamine synthetase	Bacillus subtilis subsp. subtilis str. 168	0-20
309768-5	1978	In addition to the active form of rat anaphylatoxin, a serum carboxypeptidase B inactivated form of C3a (C3ades-Arg) was purified from rat serum and utilized in subsequent structural studies.	Arginine	112-115	complement C3	Homo sapiens	100-103
677314-1	1978	Effects of intravenous arginine and cholecystokinin-pancreozymin (CCK-PZ) infusion on hepatic extraction of insulin (EI) and glucagon (EGG) and also on hepatic glucose output (HGO) were studied in anesthetized dogs.	Arginine	23-31	insulin	Canis lupus familiaris	108-115
659597-2	1978	4 wk after hypophysectomy mean fasting plasma glucose levels had declined from 90+/-2 mg/100 ml to 64+/-2; fasting and arginine-stimulated insulin and IRG levels were, respectively, approximately 50% lower and unchanged.	Arginine	119-127	insulin	Canis lupus familiaris	139-146
623297-7	1978	Arginine given 1 or 3 h after insulin withdrawal increased IRG by 100 pg/ml, and mean Ra rose by 8.9 mg/kg-min.	Arginine	0-8	insulin	Canis lupus familiaris	30-37
562936-0	1977	The effect of arginine on insulin release from the foetal sheep pancreas [proceedings].	Arginine	14-22	LOC105613195	Ovis aries	26-33
409475-0	1977	Effect of somatostatin on thyrotropin, prolactin, growth hormone and insulin responses to thyrotropin releasing hormone and arginine in healthy, hypothyroid and acromegalic subjects.	Arginine	124-132	somatostatin	Homo sapiens	10-22
266705-4	1977	Like natural C3a, the synthetic C3a=(70-77) was inactivated by digestion with carboxypeptidase B [peptidyl-L-lysine(-L-arginine) hydrolase, EC 3.4.12.3], which removed the essential COOH-terminal arginine.	Arginine	119-127	complement C3	Homo sapiens	32-35
266705-4	1977	Like natural C3a, the synthetic C3a=(70-77) was inactivated by digestion with carboxypeptidase B [peptidyl-L-lysine(-L-arginine) hydrolase, EC 3.4.12.3], which removed the essential COOH-terminal arginine.	Arginine	119-127	carboxypeptidase B1	Homo sapiens	78-96
266706-5	1977	Competitive inhibition of [3H]neurotensin binding by partial sequences of neurotensin revealed that the addition of the residue arginine-8 to the neurotensin-(9-13)-pentapeptide increases about 500-fold the relative binding potency, whereas the remaining portion of the NH2-terminal region is mainly responsible for full pharmacological potency; the COOH-terminal leucyl residue is essential for binding.	Arginine	128-136	neurotensin	Rattus norvegicus	30-41
266706-5	1977	Competitive inhibition of [3H]neurotensin binding by partial sequences of neurotensin revealed that the addition of the residue arginine-8 to the neurotensin-(9-13)-pentapeptide increases about 500-fold the relative binding potency, whereas the remaining portion of the NH2-terminal region is mainly responsible for full pharmacological potency; the COOH-terminal leucyl residue is essential for binding.	Arginine	128-136	neurotensin	Rattus norvegicus	74-85
266706-5	1977	Competitive inhibition of [3H]neurotensin binding by partial sequences of neurotensin revealed that the addition of the residue arginine-8 to the neurotensin-(9-13)-pentapeptide increases about 500-fold the relative binding potency, whereas the remaining portion of the NH2-terminal region is mainly responsible for full pharmacological potency; the COOH-terminal leucyl residue is essential for binding.	Arginine	128-136	neurotensin	Rattus norvegicus	74-85
991814-7	1976	It is concluded that: 1) in the insulin-deprived depancreatized dog, the stomach is a major source of IRG; 2) gastric IRG secretion is somehow stimulated by intravenous and intragastric arginine administration; 3) it is not influenced by intravenous or intragastric glucose administration; and 4) its release is suppressed by physiologic levels of insulin.	Arginine	186-194	insulin	Canis lupus familiaris	32-39
991814-7	1976	It is concluded that: 1) in the insulin-deprived depancreatized dog, the stomach is a major source of IRG; 2) gastric IRG secretion is somehow stimulated by intravenous and intragastric arginine administration; 3) it is not influenced by intravenous or intragastric glucose administration; and 4) its release is suppressed by physiologic levels of insulin.	Arginine	186-194	insulin	Canis lupus familiaris	348-355
129327-13	1976	The introduction of arginine was catalyzed by an inverse reaction with carboxypeptidase B, while phenylalanine or tryptophan were replaced by carboxypeptidase A.	Arginine	20-28	carboxypeptidase B1	Bos taurus	71-89
171147-3	1975	A biphasic pattern of gastrin release in response to arginine was seen in all experiments.	Arginine	53-61	gastrin	Rattus norvegicus	22-29
1138156-2	1975	In normal subjects 150 mug of somatostatin completly suppressed GH and IRI responses to arginine, while with 75 and 37.5 mug only a partial suppression was usually observed.	Arginine	88-96	somatostatin	Homo sapiens	30-42
1123347-1	1975	The structure of rat proalbumin, a liver precursor to rat serum albumin, has been determined to consist of the hexapeptide Arg-Gly-Val-Phe-Arg-Arg attached to the NH2 terminus of the polypeptide chain of rat serum albumin.	Arginine	123-126	albumin	Rattus norvegicus	24-31
1123347-1	1975	The structure of rat proalbumin, a liver precursor to rat serum albumin, has been determined to consist of the hexapeptide Arg-Gly-Val-Phe-Arg-Arg attached to the NH2 terminus of the polypeptide chain of rat serum albumin.	Arginine	123-126	albumin	Rattus norvegicus	64-71
1123347-1	1975	The structure of rat proalbumin, a liver precursor to rat serum albumin, has been determined to consist of the hexapeptide Arg-Gly-Val-Phe-Arg-Arg attached to the NH2 terminus of the polypeptide chain of rat serum albumin.	Arginine	139-142	albumin	Rattus norvegicus	24-31
1123347-1	1975	The structure of rat proalbumin, a liver precursor to rat serum albumin, has been determined to consist of the hexapeptide Arg-Gly-Val-Phe-Arg-Arg attached to the NH2 terminus of the polypeptide chain of rat serum albumin.	Arginine	139-142	albumin	Rattus norvegicus	64-71
9585299-3	1998	In this study, we examined the effects of dantrolene on L-arginine transport and activity of inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS) and interferon gamma (IFN-gamma) in rat alveolar macrophages.	Arginine	56-66	interferon gamma	Rattus norvegicus	172-199
1092707-4	1975	Similarly, the addition of somatostatin infusion completely blocked the release of insulin and growth hormone and delayed the release of glucagon stimulated by arginine infusion.	Arginine	160-168	somatostatin	Homo sapiens	27-39
9585299-4	1998	Incubation of cells with LPS (1 microg/mL) and IFN-gamma (100 u/mL) for 24 h resulted in significant increases in nitrite production and L-arginine transport.	Arginine	137-147	interferon gamma	Rattus norvegicus	47-56
1092707-5	1975	Following the somatostatin infusion there was a small rise in GH and a marked rebound for insulin and this was associated with a higher level of plasma glucose than that found following arginine infusion alone.	Arginine	186-194	somatostatin	Homo sapiens	14-26
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	proenkephalin	Rattus norvegicus	80-86
1092707-6	1975	These data establish that the administration of somatostatin can effectively block the release of insulin stimulated by arginine and glucose, can attenuate the release of glucagon induced by arginine and can enhance the glucose-mediated glucagon suppression.	Arginine	120-128	somatostatin	Homo sapiens	48-60
1092707-6	1975	These data establish that the administration of somatostatin can effectively block the release of insulin stimulated by arginine and glucose, can attenuate the release of glucagon induced by arginine and can enhance the glucose-mediated glucagon suppression.	Arginine	191-199	somatostatin	Homo sapiens	48-60
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	248-252
9558356-8	1998	IR spectroscopy on d(GGCGCC)2 indicated that the guanine absorption bands, C6=O6 and N7-C8-H, were shifted by the binding of BAP, indicative of the interactions of the arginine arms in the major groove.	Arginine	168-176	prohibitin 2	Homo sapiens	125-128
4376398-0	1974	Effect of arginine on the secretion of insulin and adenosine 3",5"-monophosphate in the pancreatic venous effluent of trained, nonanesthetized dog.	Arginine	10-18	insulin	Canis lupus familiaris	39-46
9546718-2	1998	Bovine UCRP retains the Leu-Arg-Gly-Gly C-terminal sequence of ubiquitin that ligates to and directs degradation of cytosolic proteins.	Arginine	28-31	ISG15 ubiquitin like modifier	Bos taurus	7-11
9562351-5	1998	Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p &lt; 0.05).	Arginine	98-106	selectin E	Homo sapiens	10-20
4843978-0	1974	Induction and analysis of revertants from various arg-7 mutants lacking argininosuccinate lyase in Chlamydomonas reinhardi.	Arginine	50-53	argininosuccinate lyase	Homo sapiens	72-95
9562351-5	1998	Levels of E-selectin were related to E-selectin genotype, being higher in subjects possessing the arginine allele (51.4 vs 44.5 ng/ml p &lt; 0.05).	Arginine	98-106	selectin E	Homo sapiens	37-47
5439006-0	1970	[Response of immunoreactive STH in children during simultaneous stimulation by arginine and insulin].	Arginine	79-87	saitohin	Homo sapiens	28-31
9499403-3	1998	In the yeast, Saccharomyces cerevisiae, the predominant enzyme responsible for arginine methylation is Hmt1p.	Arginine	79-87	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	103-108
5439009-0	1970	[Stimulation tests by insulin and arginine of the STH function of children].	Arginine	34-42	saitohin	Homo sapiens	50-53
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	21-29	serine and arginine repetitive matrix 1	Homo sapiens	73-79
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	21-29	serine and arginine repetitive matrix 1	Homo sapiens	81-86
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	142-150	serine and arginine repetitive matrix 1	Homo sapiens	73-79
9604801-3	1998	The aberrant localisation of AGT in PH1 is caused by the combination of a common Pro 11--&gt;Leu amino acid polymorphism which generates a functionally weak mitochondrial targeting signal (MTS) and a rare Gly170--&gt;Arg mutation which in combination with the Pro11--&gt;Leu polymorphism enhances the functional efficiency of this MTS by slowing AGT folding and dimerization.	Arginine	217-220	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	29-32
33872670-5	2021	We identified serine/arginine-related nuclear matrix protein of 160 kDa (SRm160)/SRRM1, which contains a highly phosphorylated domain rich in arginine/serine dipeptides, called the RS domain, as a nuclear protein that interacts with PGAM5.	Arginine	142-150	serine and arginine repetitive matrix 1	Homo sapiens	81-86
33410970-2	2021	Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation.	Arginine	94-104	arginase 2	Homo sapiens	35-39
9604801-3	1998	The aberrant localisation of AGT in PH1 is caused by the combination of a common Pro 11--&gt;Leu amino acid polymorphism which generates a functionally weak mitochondrial targeting signal (MTS) and a rare Gly170--&gt;Arg mutation which in combination with the Pro11--&gt;Leu polymorphism enhances the functional efficiency of this MTS by slowing AGT folding and dimerization.	Arginine	217-220	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	36-39
9452441-1	1998	Nitric oxide (NO), a physiologically important activator of soluble guanylyl cyclase (sGC), is synthesized from L-arginine and O2 in a reaction catalyzed by NO synthases (NOS).	Arginine	112-122	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	86-89
11324518-1	1998	Using extracellular recording technique, the effects of L-arginine (L-arg), SIN-1 and N-nitro-L-arginine (L-NNA) on glutamate-induced discharge of neurons in CA1 area of hippocampal slices were examined to define the role of L-arg:NO pathway in glutamate-induced discharge of hippocampal neurons and its possible underlying mechanism.	Arginine	56-66	carbonic anhydrase 1	Rattus norvegicus	158-161
34036936-4	2021	We identify a new element, the arginine-coupler, which regulates the switch-like behavior of DnaC to prevent futile ATPase cycling and maintains loader responsiveness to replication restart systems.	Arginine	31-39	ATPase	Escherichia coli	116-122
33979616-4	2021	Under arginine starvation, ASS1 transcription is induced by ATF4 and CEBPbeta binding to an enhancer within ASS1.	Arginine	6-14	activating transcription factor 4	Homo sapiens	60-64
11324518-1	1998	Using extracellular recording technique, the effects of L-arginine (L-arg), SIN-1 and N-nitro-L-arginine (L-NNA) on glutamate-induced discharge of neurons in CA1 area of hippocampal slices were examined to define the role of L-arg:NO pathway in glutamate-induced discharge of hippocampal neurons and its possible underlying mechanism.	Arginine	56-61	carbonic anhydrase 1	Rattus norvegicus	158-161
33979616-6	2021	Arginine starvation drives global chromatin compaction and repressive histone methylation, which disrupts ATF4/CEBPbeta binding and target gene transcription.	Arginine	0-8	activating transcription factor 4	Homo sapiens	106-110
11324518-1	1998	Using extracellular recording technique, the effects of L-arginine (L-arg), SIN-1 and N-nitro-L-arginine (L-NNA) on glutamate-induced discharge of neurons in CA1 area of hippocampal slices were examined to define the role of L-arg:NO pathway in glutamate-induced discharge of hippocampal neurons and its possible underlying mechanism.	Arginine	68-73	carbonic anhydrase 1	Rattus norvegicus	158-161
9544247-4	1998	That the cloned gene, KlARG8, is the functional equivalent of S. cerevisiae ARG8 was supported by a gene disruption experiment which showed that K. lactis strains carrying a deleted chromosomal copy of KlARG8 are auxotrophic for arginine.	Arginine	229-237	acetylornithine transaminase	Saccharomyces cerevisiae S288C	24-28
33961962-8	2021	CA3 FR/R ratios were higher in the absence of mEC (14N, 8SE).	Arginine	5-6	carbonic anhydrase 3	Rattus norvegicus	0-3
9450874-5	1998	This patient, a compound heterozygote, showed two mutations in ATM: one missense mutation leading to a Leu2656Pro substitution and the other to the truncation at codon 3047 (Arg-->ter).	Arginine	174-177	ATM serine/threonine kinase	Homo sapiens	63-66
33579815-5	2021	Further metabolomic analysis revealed that CAT1-overexpressed EVs drastically enhanced vascular endothelial cell growth and tubule formation via upregulation of arginine transport and downstream nitric oxide metabolic pathway.	Arginine	161-169	solute carrier family 7 member 1	Homo sapiens	43-47
9781342-3	1998	Consecutive removal of N-terminal arginine residues from hLf progressively increased the binding affinity but decreased the number of binding sites on the cells.	Arginine	34-42	HLF transcription factor, PAR bZIP family member	Homo sapiens	57-60
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	protein arginine methyltransferase 7	Homo sapiens	143-179
33927350-3	2021	In this study, we discovered that arginine 21(R21) and lysine 108 (K108) of mitochondrial ribosomal protein S23 (MRPS23) was methylated by the protein arginine methyltransferase 7 (PRMT7) and SET-domain-containing protein 6 (SETD6), respectively.	Arginine	34-42	protein arginine methyltransferase 7	Homo sapiens	181-186
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32--&gt;Glu and Arg-42--&gt; Gly substitutions.	Arginine	131-134	glutathione S-transferase zeta 1	Homo sapiens	48-53
33893278-0	2021	Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells.	Arginine	0-8	TEA domain transcription factor 4	Homo sapiens	46-51
33893278-5	2021	TEAD4 is retained in the nucleus by arginine, enhancing its recruitment to the promoter/enhancer regions of OXPHOS genes and mediating coordinated upregulation in a YAP1-independent but mTOR-dependent manner.	Arginine	36-44	TEA domain transcription factor 4	Homo sapiens	0-5
33893278-6	2021	Arginine also activates the expression of lysine acetyl-transferases and increases overall levels of acetylated histones and acetyl-CoA, facilitating TEAD4 recruitment.	Arginine	0-8	TEA domain transcription factor 4	Homo sapiens	150-155
9838244-0	1998	Homozygous deletion of arginine-173 in the CYP11B2 gene in a girl with congenital hypoaldosteronism.	Arginine	23-31	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	43-50
33783499-0	2021	C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.	Arginine	19-27	staufen	Drosophila melanogaster	96-103
9838244-7	1998	CYP11B2 is polymorphic at this position, encoding arginine or lysine.	Arginine	50-58	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	0-7
9595387-2	1998	To clarify the relationships between the second processing step and the third, we introduced point mutation into ET-1 cDNA to replace the Arg in the -4 position of the recognition motifs of furin-like convertase in human preproET-1 (Arg49 or Arg89) by Gly.	Arginine	138-141	furin	Cricetulus griseus	190-195
33750826-5	2021	Analysis of recombinant BmGalNAcT expressed in Sf9 cells showed that BmGalNAcT transferred GalNAc to non-reducing terminals of GlcNAcbeta1,2-R with beta1,4-linkage.	Arginine	140-142	N-acetylgalactosaminyltransferase 7	Bombyx mori	24-33
33750826-5	2021	Analysis of recombinant BmGalNAcT expressed in Sf9 cells showed that BmGalNAcT transferred GalNAc to non-reducing terminals of GlcNAcbeta1,2-R with beta1,4-linkage.	Arginine	140-142	N-acetylgalactosaminyltransferase 7	Bombyx mori	69-78
9660106-6	1998	The CSF/plasma ratios of phosphoserine, serine, citrulline, alfa-aminobutyric acid and arginine were significantly lower in AD patients than those of controls.	Arginine	87-95	colony stimulating factor 2	Homo sapiens	4-7
33459381-0	2021	m6 A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	32-37
33459381-0	2021	m6 A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region.	Arginine	47-55	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	71-78
33459381-2	2021	Here, we establish arginine methylation of METTL14, a component of the m6 A methyltransferase complex, as a novel pathway that controls m6 A deposition in mammalian cells.	Arginine	19-27	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	43-50
9426281-6	1997	ASE-1 was found to contain two domains that are present in a number of nucleolar specific proteins originating from a variety of organisms: a glycine-, arginine- and phenylalanine-rich putative nucleotide interaction domain and an alternating basic/acidic region.	Arginine	152-160	RNA polymerase I subunit G	Homo sapiens	0-5
9476130-6	1997	This mutation is very similar to a mutation previously described in another case of functional C1q deficiency where Gly at position 6 of the C chain was substituted by a large positively charged residue (Arg).	Arginine	204-207	complement C1q A chain	Homo sapiens	95-98
33373331-3	2021	Argininosuccinate lyase (ASL) is the only mammalian enzyme capable of synthesizing arginine, the sole precursor for nitric oxide synthase (NOS)-dependent NO synthesis.	Arginine	83-91	argininosuccinate lyase	Homo sapiens	0-23
33373331-3	2021	Argininosuccinate lyase (ASL) is the only mammalian enzyme capable of synthesizing arginine, the sole precursor for nitric oxide synthase (NOS)-dependent NO synthesis.	Arginine	83-91	argininosuccinate lyase	Homo sapiens	25-28
33373331-4	2021	Moreover, ASL is also required for channeling extracellular arginine to NOS for NO production.	Arginine	60-68	argininosuccinate lyase	Homo sapiens	10-13
9398525-6	1997	These results and the fact that selD-like possesses an arginine residue at the position of the essential Cys17 (E. coli nomenclature) indicate that the Drosophila gene exerts a function different from that of the classical selenophosphate synthetases.	Arginine	55-63	Selenophosphate synthetase 1	Drosophila melanogaster	32-41
33207269-1	2021	Plant Cysteine Oxidases (PCOs) play important roles in controlling the stability of Group VII ethylene response factors (ERF-VIIs) via N-Arg/degron pathway through catalyzing the oxidation of their N-Cys for subsequent Arginyl-tRNA--protein transferase 1 (ATE1) mediated arginine installation.	Arginine	271-279	arginine-tRNA protein transferase 1	Arabidopsis thaliana	219-254
33207269-1	2021	Plant Cysteine Oxidases (PCOs) play important roles in controlling the stability of Group VII ethylene response factors (ERF-VIIs) via N-Arg/degron pathway through catalyzing the oxidation of their N-Cys for subsequent Arginyl-tRNA--protein transferase 1 (ATE1) mediated arginine installation.	Arginine	271-279	arginine-tRNA protein transferase 1	Arabidopsis thaliana	256-260
9366434-4	1997	The concentration of L-NMMA for inhibition of MIP-1 alpha release was dependent on the concentration of L-arginine in the cell culture medium, emphasizing the L-arginine-related action of the drug.	Arginine	104-114	C-C motif chemokine ligand 3	Homo sapiens	46-57
33755849-7	2021	Induction of MI/R model resulted in cardiac dysfunction, oxidative stress, increased activity of RIPK1-RIPK3-MLKL axis and RhoA/ROCK pathway, extension of fibrosis and heart tissue damage.	Arginine	16-17	receptor interacting serine/threonine kinase 1	Rattus norvegicus	97-102
33755849-7	2021	Induction of MI/R model resulted in cardiac dysfunction, oxidative stress, increased activity of RIPK1-RIPK3-MLKL axis and RhoA/ROCK pathway, extension of fibrosis and heart tissue damage.	Arginine	16-17	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	103-108
9366434-4	1997	The concentration of L-NMMA for inhibition of MIP-1 alpha release was dependent on the concentration of L-arginine in the cell culture medium, emphasizing the L-arginine-related action of the drug.	Arginine	159-169	C-C motif chemokine ligand 3	Homo sapiens	46-57
33755849-7	2021	Induction of MI/R model resulted in cardiac dysfunction, oxidative stress, increased activity of RIPK1-RIPK3-MLKL axis and RhoA/ROCK pathway, extension of fibrosis and heart tissue damage.	Arginine	16-17	ras homolog family member A	Rattus norvegicus	123-127
9366443-6	1997	L-arginine treatment enhanced cytokine mRNA expression, particularly of IFN-gamma, which was detected earlier than in control animals, corresponding with the more rapid onset of disease and increased disease severity observed in this group.	Arginine	0-10	interferon gamma	Rattus norvegicus	72-81
9581564-4	1997	Consecutive removal of N-terminal arginine residues from hLf progressively increased the binding affinity but decreased the number of binding sites on the cells.	Arginine	34-42	HLF transcription factor, PAR bZIP family member	Homo sapiens	57-60
33718701-0	2021	Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.	Arginine	23-31	euchromatic histone lysine methyltransferase 2	Homo sapiens	49-52
33718701-10	2021	Moreover, the presence of both lysine and arginine mimics together shows a drastic increase in the binding affinity of the inhibitor towards G9a.	Arginine	42-50	euchromatic histone lysine methyltransferase 2	Homo sapiens	141-144
33718701-11	2021	Hence, we propose incorporating a guanidine group to imitate the substrate arginine"s side chain in the inhibitor design to improve the potency of G9a inhibitors.	Arginine	75-83	euchromatic histone lysine methyltransferase 2	Homo sapiens	147-150
9343420-6	1997	The replacement of three arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding and inhibition of MyoD by M-Twist, while the domain retained other M-Twist functions such as heterodimerization with an E protein and inhibition of MEF2 transactivation.	Arginine	25-33	myogenic differentiation 1	Mus musculus	144-148
33418111-0	2021	Asymmetrical Arginine Dimethylation of Histone H4 by 8-oxoG/OGG1/PRMT1 is Essential for Oxidative Stress-induced Transcription Activation.	Arginine	13-21	protein arginine methyltransferase 1	Homo sapiens	65-70
9341152-12	1997	For optimal LPC substrate processing activity, an arginine at position P-6 is preferred over an arginine at P-4.	Arginine	96-104	solute carrier family 10 member 4	Homo sapiens	108-111
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	caspase 3	Mus musculus	140-149
33594058-2	2021	Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1).	Arginine	8-16	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	122-129
9409415-0	1997	Quantification of regional cerebral blood flow and vascular reserve in childhood moyamoya disease using [123I]IMP-ARG method.	Arginine	114-117	inositol monophosphatase 1	Homo sapiens	110-113
33594058-2	2021	Whereas arginine activates mTORC1, it is overridden by high expression of cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1).	Arginine	84-92	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	122-129
33594058-8	2021	Significantly, AKT and RNF167-mediated CASTOR1 degradation activates mTORC1 independent of arginine and promotes breast cancer progression.	Arginine	91-99	ring finger protein 167	Homo sapiens	23-29
33594058-8	2021	Significantly, AKT and RNF167-mediated CASTOR1 degradation activates mTORC1 independent of arginine and promotes breast cancer progression.	Arginine	91-99	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	39-46
9409415-5	1997	Quantification of both resting rCBF and rVR using IMP-ARG method could provide reliable information concerning on surgical indication and its effectiveness in childhood Moyamoya disease.	Arginine	54-57	inositol monophosphatase 1	Homo sapiens	50-53
9317167-3	1997	Both cleavage sites are immediately after an arginine residue at position 653 for IA-2 and position 679 for IA-2 beta.	Arginine	45-53	protein tyrosine phosphatase receptor type N2	Homo sapiens	108-117
20229294-2	1997	The carboxyl and the hydroxy groups were protected by tBu; the side chains of Lys and His were protected by Boc; the guanidine group of Arg was protected by Mtr and the mercaptan group of Cys was protected by Trt.	Arginine	136-139	telomerase RNA component	Mus musculus	157-160
33420374-0	2021	PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer.	Arginine	25-33	protein arginine methyltransferase 1	Homo sapiens	0-5
9268337-9	1997	These results demonstrate, that the Trp68 --&gt; Arg substitution in human Fuc-TIII is the capital amino acid change responsible for the appearance of the Le(a-b-) phenotype on human erythrocytes in individuals homozygous for both the T202C and C314T mutations.	Arginine	49-52	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	75-83
33485325-6	2021	This study aimed to characterize the effect of mutation at the 343 site of CXCR4 causing the replacement of arginine/E with glutamic acid/K on the receptor signal transduction, and elucidate the mechanism underling CXCR4E343K causing WHIM in the reported family.	Arginine	108-116	C-X-C motif chemokine receptor 4	Homo sapiens	75-80
33485325-6	2021	This study aimed to characterize the effect of mutation at the 343 site of CXCR4 causing the replacement of arginine/E with glutamic acid/K on the receptor signal transduction, and elucidate the mechanism underling CXCR4E343K causing WHIM in the reported family.	Arginine	108-116	C-X-C motif chemokine receptor 4	Homo sapiens	215-220
9277491-9	1997	The effects of SPM-5185 and L-arginine were also paralleled by decreases in P-selectin protein synthesis and in decreased adherence of human neutrophils to human iliac venous endothelial cells.	Arginine	28-38	selectin P	Homo sapiens	76-86
33644712-2	2021	Here, we show that the nonreceptor kinases c-Abl and Arg directly interact with STAT1 and potentiate the phosphorylation of STAT1 on Y701.	Arginine	53-56	signal transducer and activator of transcription 1	Homo sapiens	80-85
33644712-2	2021	Here, we show that the nonreceptor kinases c-Abl and Arg directly interact with STAT1 and potentiate the phosphorylation of STAT1 on Y701.	Arginine	53-56	signal transducer and activator of transcription 1	Homo sapiens	124-129
33644712-3	2021	c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation.	Arginine	6-9	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5
33644712-3	2021	c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation.	Arginine	6-9	signal transducer and activator of transcription 1	Homo sapiens	24-29
9279753-2	1997	One such point mutation, resulting in the substitution of proline by arginine in a critical region of the linker region between the first and second immunoglobulin-like domains, is associated with highly specific phenotypic consequences in that mutation at this point in FGFR1 results in Pfeiffer syndrome and analogous mutation in FGFR2 results in Apert syndrome.	Arginine	69-77	fibroblast growth factor receptor 2	Homo sapiens	332-337
33644712-3	2021	c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNgamma and potentiate IFNgamma-mediated STAT1 phosphorylation.	Arginine	6-9	signal transducer and activator of transcription 1	Homo sapiens	135-140
33644712-6	2021	Compared to vehicle, administration of the c-Abl/Arg selective inhibitor AMN107 resulted in significantly increased mortality in mice infected with human influenza virus.	Arginine	49-52	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	43-48
9237760-2	1997	U2AF65 binds to RNA at the polypyrimidine tract, whereas U2AF35 is thought to interact through its arginine/serine-rich (RS) domain with other RS-domain-containing factors bound at the 5" splice site, assembled in splicing enhancer complexes, or associated with the U4/U6.U5 small nuclear ribonucleoprotein complex.	Arginine	99-107	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	57-63
33495408-10	2021	Furthermore, CARM1 regulates arginine methylation of Smad7, activates the TGF-beta/Smad pathway and induces epithelial-to-mesenchymal transition (EMT), thereby promoting SCLC chemoresistance.	Arginine	29-37	coactivator associated arginine methyltransferase 1	Homo sapiens	13-18
9166749-2	1997	We have isolated a decapeptide (Leu-Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe) from sheep brain that binds with high affinity to the angiotensin IV receptor.	Arginine	64-67	AT4 receptor	Ovis aries	127-150
33440945-2	2021	Using activity-based protein profiling, we first demonstrated that BBR directly targets the NEK7 protein via the hydrogen bond between the 2,3-methylenedioxy and 121-arginine (R121) residues.	Arginine	166-174	NIMA related kinase 7	Homo sapiens	92-96
33440850-5	2021	Cp deamidation occurs at two Asparagine-Glycine-Arginine (NGR)-motifs which, once deamidated to isoAspartate-Glycine-Arginine (isoDGR), bind integrins, a family of receptors mediating cell adhesion.	Arginine	48-56	reticulon 4 receptor	Homo sapiens	58-61
33410556-1	2021	Arginine activity in broiler diets can be supplied by L-arginine (Arg), guanidinoacetic acid (GAA) and L-citrulline (Cit), all of which are commercially available.	Arginine	0-8	citron rho-interacting serine/threonine kinase	Gallus gallus	117-120
33410556-1	2021	Arginine activity in broiler diets can be supplied by L-arginine (Arg), guanidinoacetic acid (GAA) and L-citrulline (Cit), all of which are commercially available.	Arginine	0-3	citron rho-interacting serine/threonine kinase	Gallus gallus	117-120
33410556-10	2021	The findings indicate that Cit is an efficacious source of Arg activity in Arg-deficient diets.	Arginine	59-62	citron rho-interacting serine/threonine kinase	Gallus gallus	27-30
33410556-10	2021	The findings indicate that Cit is an efficacious source of Arg activity in Arg-deficient diets.	Arginine	75-78	citron rho-interacting serine/threonine kinase	Gallus gallus	27-30
9153254-3	1997	The mutation of Arg-51 of LTC4S to Thr or Ile abolishes the enzyme function, whereas the mutation of Arg-51 to His or Lys provides a fully active recombinant protein.	Arginine	16-19	leukotriene C4 synthase	Homo sapiens	26-31
33415686-2	2021	Coactivator-associated arginine methyltransferase 1 (CARM1), an epigenetic regulator of histone arginine methylation, is a highly interesting target in neuroplasticity.	Arginine	23-31	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	53-58
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	solute carrier family 38 member 9	Bos taurus	166-173
9153254-9	1997	These results suggest that in the catalytic function of LTC4S, Arg-51 probably opens the epoxide ring and Tyr-93 provides the thiolate anion of GSH.	Arginine	63-66	leukotriene C4 synthase	Homo sapiens	56-61
9283624-9	1997	Deletion of CT by 84% did not affect CO2 sensitivity, but replacement of 5 arginines (R) with asparagines (N) at the beginning of CT (C1) greatly enhanced the CO2 sensitivity of Cx32.	Arginine	75-84	gap junction protein beta 1 L homeolog	Xenopus laevis	178-182
33380261-0	2022	Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5.	Arginine	42-50	protein arginine methyltransferase 1	Homo sapiens	79-84
33380261-2	2022	In this study, we determined how local changes on adjacent residues in the histone H4 substrate regulate arginine asymmetric dimethylation and symmetric dimethylation catalysed by the major protein arginine methyltransferase (PRMT) enzymes PRMT1 and PRMT5, respectively.	Arginine	105-113	protein arginine methyltransferase 1	Homo sapiens	240-245
33257578-6	2020	In this model, SPINDOC interacts with the SPIN1 interface previously shown to bind a lysine and arginine methylated sequence of histone H3.	Arginine	96-104	spindlin 1	Homo sapiens	42-47
33300219-6	2021	Moreover, site-directed mutagenesis revealed that the conserved arginine residues R265 and R306 of Rtt109 are required for the H3K9 and H3K56 acetylation and virulence of A. fumigatus.	Arginine	64-72	H3 histone acetyltransferase RTT109	Saccharomyces cerevisiae S288C	99-105
33317138-5	2020	RESULTS: A2AP 6Trp carriage was associated with VEGF elevation (OR: 2.37, 95% CI: 1.06-5.29) and VEGF levels (6Trp, 455 +- 334 pg/mL; 6Arg/Arg, 373 +- 293 pg/mL; p < 0.008).	Arginine	135-138	serpin family F member 2	Homo sapiens	9-13
33835003-13	2020	A heterozygous single nucleotide substitution c.6127G>A in exon 73 of COL7A1 was found, which converts glycine to arginine residue, designated p. G2043R.	Arginine	114-122	collagen type VII alpha 1 chain	Homo sapiens	70-76
32725514-0	2020	IFN-gamma Activates the TLR4-CCL5 Signaling Through Reducing Arginine Level, Leading to Enhanced Susceptibility of Bovine Mammary Epithelial Cells to Staphylococcus aureus.	Arginine	61-69	interferon gamma	Bos taurus	0-9
32932187-9	2020	Interestingly, as a precursor of nitric oxide, Arg supplementation can rescue the effects of feed restriction on follicular development by enhancing glucose metabolism and cell proliferation of GCs, and alleviating the abnormal E2 secretion in the >=2.5 mm follicles, accompanied with recovering the expressions of NPVF and GNRH in the hypothalamus.	Arginine	47-50	pro-FMRFamide-related neuropeptide VF	Ovis aries	315-319
33266231-2	2020	However, at an inflammatory focus, arginine residues in LL-37 can be converted to citrulline via a reaction catalyzed by peptidyl-arginine deiminases (PAD2 and PAD4), which are expressed in neutrophils and are highly active during the formation of neutrophil extracellular traps (NETs).	Arginine	35-43	peptidyl arginine deiminase 2	Homo sapiens	151-155
33217972-5	2020	Our findings revealed that CPZ has a strict requirement for substrates with C-terminal Arg or Lys at the P1" position.	Arginine	87-90	carboxypeptidase Z	Homo sapiens	27-30
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	36-39	neuropilin 2	Homo sapiens	182-186
33082294-3	2020	Cleavage of S generates a polybasic Arg-Arg-Ala-Arg carboxyl-terminal sequence on S1, which conforms to a C-end rule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.	Arginine	40-43	neuropilin 2	Homo sapiens	182-186
32918517-2	2020	Here, we show protein arginine methyltransferase 1 (PRMT1), a key enzyme that catalyzes the protein arginine methylation process, particularly the isoform encoded by Prmt1 variant 2 (PRMT1V2), is critical in regulating gluconeogenesis in the liver.	Arginine	22-30	protein arginine methyltransferase 1	Homo sapiens	52-57
33047125-1	2020	This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2 and SLC6A14 in mammary parenchymal tissue.	Arginine	74-77	solute carrier family 7 member 1	Homo sapiens	177-183
33047125-1	2020	This study was conducted to test the hypothesis that supplemental dietary Arg to late-pregnant and lactating sows increases serum prolactin concentrations and mRNA abundance of SLC7A1, SLC7A2 and SLC6A14 in mammary parenchymal tissue.	Arginine	74-77	solute carrier family 6 member 14	Homo sapiens	196-203
33047125-14	2020	Dietary Arg supplementation at a rate of 0.10 g/kg BW during late pregnancy and lactation tended to increase serum prolactin concentrations with no increase in mammary transcript abundance of SLC7A1, SLC7A2 and SLC6A14 in early lactation.	Arginine	8-11	solute carrier family 6 member 14	Homo sapiens	211-218
33209975-7	2020	Furthermore, experimental results also suggested that solute carrier family 7 member 1 (SLC7A1) might be a substrate of SPOP and influence cell phenotype by regulating arginine metabolism.	Arginine	168-176	solute carrier family 7 member 1	Homo sapiens	54-86
33209975-7	2020	Furthermore, experimental results also suggested that solute carrier family 7 member 1 (SLC7A1) might be a substrate of SPOP and influence cell phenotype by regulating arginine metabolism.	Arginine	168-176	solute carrier family 7 member 1	Homo sapiens	88-94
33209975-7	2020	Furthermore, experimental results also suggested that solute carrier family 7 member 1 (SLC7A1) might be a substrate of SPOP and influence cell phenotype by regulating arginine metabolism.	Arginine	168-176	speckle type BTB/POZ protein	Homo sapiens	120-124
32970693-5	2020	In this study, we identified a functional putative nuclear localization signal (NLS) of PNKP located in the linker region, and showed that lysine 138 (K138), arginine 139 (R139) and arginine 141 (R141) residues therein are critically important for nuclear localization.	Arginine	182-190	polynucleotide kinase 3'-phosphatase	Homo sapiens	88-92
32970693-6	2020	Furthermore, double mutant of K138A and R35A, the latter of which mutates arginine 35, central amino acid of FHA domain, showed additive effect on nuclear localization, indicating that the FHA domain as well as the NLS is important for PNKP nuclear localization.	Arginine	74-82	polynucleotide kinase 3'-phosphatase	Homo sapiens	236-240
32297247-5	2020	RESULTS: Gln/Arg heterozygous variant of XRCC1 gene"s p.Gln399Arg locus, as well as combined carriage of Arg/Gln//Arg/Pro of XRCC1/TP53; Arg/Gln//T/T of XRCC1/MDM2; Arg/Gln//G/G and Arg/Gln//G/A of XRCC1/TNFalpha, Arg/Gln//T/T of XRCC1/PALB2; Arg/Gln//Arg/Arg and Arg/Gln//Arg/Trp for p.Gln399Arg and p.Arg194Trp polymorphic loci of XRCC1 were associated with BC in Kyrgyz females.	Arginine	13-16	X-ray repair cross complementing 1	Homo sapiens	41-46
32157557-4	2020	Here we show that ribose-5-phosphate isomerase A (RPIA), an enzyme in PPP, directly interacts with co-activator associated arginine methyltransferase 1 (CARM1) and is methylated at arginine 42 (R42).	Arginine	123-131	coactivator associated arginine methyltransferase 1	Homo sapiens	153-158
32583741-0	2020	SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis.	Arginine	6-14	protein arginine methyltransferase 1	Homo sapiens	30-35
32753055-6	2020	Greater toxicity correlated with a short and unstructured carboxyl terminus (C-terminus) in the glycine-arginine (GR) RAN protein reading frame.	Arginine	104-112	Ran	Drosophila melanogaster	118-121
32562117-4	2020	RESULTS: For XRCC1, heterozygous Arg/Gln and homozygous Gln/Gln genotypes showed 1.78-fold (95% CI 1.0084 to 3.1442, p = 0.0467) and 2.41-fold (95% CI 1.0354 to 5.5914, p = 0.0413) increased risk of breast cancer, respectively, when compared with Arg/Arg genotype.	Arginine	33-36	X-ray repair cross complementing 1	Homo sapiens	13-18
32562117-4	2020	RESULTS: For XRCC1, heterozygous Arg/Gln and homozygous Gln/Gln genotypes showed 1.78-fold (95% CI 1.0084 to 3.1442, p = 0.0467) and 2.41-fold (95% CI 1.0354 to 5.5914, p = 0.0413) increased risk of breast cancer, respectively, when compared with Arg/Arg genotype.	Arginine	247-250	X-ray repair cross complementing 1	Homo sapiens	13-18
32562117-4	2020	RESULTS: For XRCC1, heterozygous Arg/Gln and homozygous Gln/Gln genotypes showed 1.78-fold (95% CI 1.0084 to 3.1442, p = 0.0467) and 2.41-fold (95% CI 1.0354 to 5.5914, p = 0.0413) increased risk of breast cancer, respectively, when compared with Arg/Arg genotype.	Arginine	247-250	X-ray repair cross complementing 1	Homo sapiens	13-18
32687545-3	2020	MD simulations reveal that the intermolecular interactions preferentially occur between specific PIP2 phosphate groups and hPLD2 residues; the most strongly interacting residues are arginine at the pbox consensus sequence (PX) and pleckstrin homology (PH) domain.	Arginine	182-190	phospholipase D2	Homo sapiens	123-128
32754051-6	2020	Moreover, L-arginine administration prevented the HS-induced myh7b and PGC1alpha mRNAs content decreases and slow-type genes repressor SOX6 mRNA transcription increase.	Arginine	10-20	SRY-box transcription factor 6	Rattus norvegicus	135-139
32642843-0	2020	Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells.	Arginine	27-35	solute carrier organic anion transporter family, member 4C1	Mus musculus	105-112
32642843-7	2020	These results indicate that both OATP4C1 and P-gp transport the arginine derivatives ADMA and L-homoarginine and are, therefore, important for the homoeostasis of both substances.	Arginine	64-72	solute carrier organic anion transporter family, member 4C1	Mus musculus	33-40
32642843-7	2020	These results indicate that both OATP4C1 and P-gp transport the arginine derivatives ADMA and L-homoarginine and are, therefore, important for the homoeostasis of both substances.	Arginine	64-72	phosphoglycolate phosphatase	Mus musculus	45-49
32711445-9	2020	RESULTS: Administration of L-arginine to cisplatin-treated rats induced significant decrease in the average ABR threshold shifts at all frequencies, tissue TGF-beta1, TNF-alpha and IL-15 associated with significant increase in tissue antioxidant enzymes, total nitrate/nitrite and Nrf2/HO-1 content compared to cisplatin group.	Arginine	27-37	heme oxygenase 1	Rattus norvegicus	286-290
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	15-23	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	51-56
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	15-23	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	164-169
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	15-23	insulin II	Mus musculus	170-180
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	81-89	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	164-169
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	81-89	insulin II	Mus musculus	170-180
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	81-89	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	164-169
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	81-89	insulin II	Mus musculus	170-180
32688289-1	2020	PURPOSE: Integrin alphavbeta3, a member of the arginine-glycine-aspartate (RGD)-binding subfamily, is associated with tumor angiogenesis and metastasis.	Arginine	47-55	integrin subunit alpha V	Homo sapiens	9-29
32487995-4	2020	We report a dramatic reduction in serum amyloid A1 protein in ICM hearts, perturbed thyroid hormone signalling pathways and significant reductions in oxidoreductase co-factor riboflavin-5-monophosphate and glycolytic intermediate fructose-6-phosphate in both; unveil gender-specific changes in HF, including nitric oxide-related arginine metabolism, mitochondrial substrates, and X chromosome-linked protein and metabolite changes; and provide an interactive online application as a publicly-available resource.	Arginine	329-337	thioredoxin reductase 1	Homo sapiens	150-164
32356124-13	2020	Online protein structure predictions revealed that BRCA1 (3326A>T) mutations mutated AGA at this site to TGA resulting in a translated Arg (arginine) mutation as a stop codon, while BRCA2 (1342A>C) mutated AAT at this site to CAT resulting in a translated Asn mutation to His.	Arginine	135-138	BRCA1 DNA repair associated	Homo sapiens	51-56
32356124-13	2020	Online protein structure predictions revealed that BRCA1 (3326A>T) mutations mutated AGA at this site to TGA resulting in a translated Arg (arginine) mutation as a stop codon, while BRCA2 (1342A>C) mutated AAT at this site to CAT resulting in a translated Asn mutation to His.	Arginine	140-148	BRCA1 DNA repair associated	Homo sapiens	51-56
32165314-1	2020	Insulin regulates the l-arginine/nitric oxide (NO) pathway in human umbilical vein endothelial cells (HUVECs), increasing the plasma membrane expression of the l-arginine transporter hCAT-1 and inducing vasodilation in umbilical and placental veins.	Arginine	22-32	solute carrier family 7 member 1	Homo sapiens	183-189
32165314-7	2020	The inhibition of intermediate-conductance KCa (IKCa) and BKCa increases l-arginine uptake, which was related with protein abundance of hCAT-1 in HUVECs.	Arginine	73-83	solute carrier family 7 member 1	Homo sapiens	136-142
32550227-7	2020	These sites were codes for amino acids such as arginine, proline, lysine, and leucine indicating major roles for the function of immunological proteins, and in particular, the study highlighted the importance of changes in gene expression of AKT3 on immunity.	Arginine	47-55	AKT serine/threonine kinase 3	Homo sapiens	242-246
32198280-6	2020	The combined inhibition of MAP4K4 and Arg by bosutinib preserved adherens junction integrity and reduced turnover of focal adhesions, which synergistically act to stabilize the endothelial barrier during inflammation.Conclusion: MAP4K4 was identified as important regulator of endothelial barrier integrity, increasing focal adhesion turnover and disruption of cell-cell junctions during inflammation.	Arginine	38-41	mitogen-activated protein kinase kinase kinase kinase 4	Mus musculus	229-235
32391010-4	2020	IL-17A levels reduced but IL-17F levels increased significantly in the colorectum of Arg myeKO mice, leading to severe tissue damage and high risk of mortality rate.	Arginine	85-88	interleukin 17A	Mus musculus	0-6
32494597-4	2020	Here, we report the cryo-EM structure of the human b0,+AT-rBAT complex alone and in complex with arginine substrate at resolution of 2.7 and 2.3 A, respectively.	Arginine	97-105	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	58-62
32306102-9	2020	The conservation of plant ACRs is reminiscent of that of human cellular arginine sensor for mTORC1 (CASTOR1), a member of a small protein family highly conserved in animals.	Arginine	72-80	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	100-107
32169720-9	2020	The RT-PCR analysis confirmed the modifications of Fibrillin-1, ADAMTSL4, Basigin and Xanthine Oxidase, whose expression levels increase after stimulation with LPS and are reduced by l-Arginine (p < 0.05).	Arginine	183-193	basigin	Bos taurus	74-81
32245218-5	2020	This scaffold mimics the buried amino acid sequence Ile-25` to Arg-28` at the core of NS4A21`-33` needed to activate the NS3 protease.	Arginine	63-66	KRAS proto-oncogene, GTPase	Homo sapiens	121-124
31779731-5	2020	Furthermore, 1 0 % Arg supplementation significantly up-regulated PPAR-gamma coactivator-1alpha (PGC-1alpha), sirtuin 1 and cytochrome c (Cytc) protein expressions, increased PGC-1alpha, nuclear respiratory factor 1 (NRF1), mitochondria transcription factor B1 (TFB1M), Cytc and ATP synthase subunit C1 (ATP5G) mRNA levels and increased mitochondrial DNA content.	Arginine	19-22	sirtuin 1	Homo sapiens	110-119
32070010-5	2020	Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher.	Arginine	10-20	glial fibrillary acidic protein	Rattus norvegicus	139-170
32070010-5	2020	Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher.	Arginine	10-20	glial fibrillary acidic protein	Rattus norvegicus	172-176
31571563-7	2020	Compared with the Control, the infusion of Arg led to greater concentrations of total protein, immunoglobulin M and high density lipoprotein cholesterol coupled with lower concentrations of haptoglobin and tumor necrosis factor-alpha, and activity of aspartate aminotransferase in serum.	Arginine	43-46	haptoglobin	Bos taurus	190-201
32063725-0	2020	l-arginine Supplementation Increased Only Endothelium-Dependent Relaxation in Sprague-Dawley Rats Fed a High-Salt Diet by Enhancing Abdominal Aorta Endothelial Nitric Oxide Synthase Gene Expression.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	148-181
32063725-3	2020	Objectives: This study was designed to investigate the mechanism by which oral l-arginine supplementation modulates vascular reactivity and eNOS gene expression in Sprague-Dawley rats fed a high-salt diet.	Arginine	79-89	nitric oxide synthase 3	Rattus norvegicus	140-144
32063725-10	2020	However, l-arginine supplementation improved the impaired endothelium-dependent relaxation and nitric oxide level while ameliorating the reduced eNOS gene expressions.	Arginine	9-19	nitric oxide synthase 3	Rattus norvegicus	145-149
32063725-11	2020	Conclusion: This study suggests that oral supplementation of l-arginine enhances endothelial-dependent relaxation in rats fed a high-salt diet by ameliorating eNOS gene expression in the abdominal aorta of the rats.	Arginine	61-71	nitric oxide synthase 3	Rattus norvegicus	159-163
31647043-7	2020	l-Arg also decreased the expression of arginase II in the ileum, arginine:glycine amidinotransferase in the liver and the kidney and glyoxalase I in the liver, ileum and brain, but increased the expression of arginine decarboxylase and polyamines levels in the liver.	Arginine	0-5	arginase 2	Rattus norvegicus	39-50
31647043-7	2020	l-Arg also decreased the expression of arginase II in the ileum, arginine:glycine amidinotransferase in the liver and the kidney and glyoxalase I in the liver, ileum and brain, but increased the expression of arginine decarboxylase and polyamines levels in the liver.	Arginine	0-5	antizyme inhibitor 2	Rattus norvegicus	209-231
31979015-2	2020	Arginase 2 (Arg2) is an enzyme involved in L-arginine metabolism and is expressed in macrophages and nervous tissue.	Arginine	43-53	arginase type II	Mus musculus	0-10
31979015-2	2020	Arginase 2 (Arg2) is an enzyme involved in L-arginine metabolism and is expressed in macrophages and nervous tissue.	Arginine	43-53	arginase type II	Mus musculus	12-16
31937813-2	2020	Nitric oxide (NO-) is a member of RNS produced from arginine by inducible Nitric Oxide Synthase (iNOS) enzyme.	Arginine	52-60	nitric oxide synthase 2	Bos taurus	64-95
31937813-2	2020	Nitric oxide (NO-) is a member of RNS produced from arginine by inducible Nitric Oxide Synthase (iNOS) enzyme.	Arginine	52-60	nitric oxide synthase 2	Bos taurus	97-101
31802658-8	2020	The synthetic process was varied in terms of ratios of zinc chloride and l-arginine in the core to entrap the glucagon-like peptide 1 analogue, exenatide, and bovine serum albumin.	Arginine	73-83	glucagon	Rattus norvegicus	110-133
31802658-8	2020	The synthetic process was varied in terms of ratios of zinc chloride and l-arginine in the core to entrap the glucagon-like peptide 1 analogue, exenatide, and bovine serum albumin.	Arginine	73-83	albumin	Rattus norvegicus	166-179
32153738-3	2020	In this study, an attempt was made to evaluate the efficiency of an arginine-rich CPP, HR9, in HCV NS3 gene delivery compared to TurboFect cationic polymer and supercharged +36 GFP into HEK-293T cells.	Arginine	68-76	KRAS proto-oncogene, GTPase	Homo sapiens	99-102
31000813-7	2020	PRMT7 interacts with and methylates GLI2 on arginine residues 225 and 227 nearby a binding region of SUFU, a negative regulator of GLI2.	Arginine	44-52	GLI-Kruppel family member GLI2	Mus musculus	36-40
31709652-9	2020	L-arginine induced autophagy, which was demonstrated by decreased expression of p62 and p-mTOR/mTOR, and increased expression of LC3B.	Arginine	0-10	mechanistic target of rapamycin kinase	Rattus norvegicus	90-94
31709652-9	2020	L-arginine induced autophagy, which was demonstrated by decreased expression of p62 and p-mTOR/mTOR, and increased expression of LC3B.	Arginine	0-10	mechanistic target of rapamycin kinase	Rattus norvegicus	95-99
31189070-2	2019	SLC6A14-mediated l-arginine transport has been shown to augment the residual anion channel activity of the major mutant, F508del-CFTR, in the murine gastrointestinal tract.	Arginine	17-27	cystic fibrosis transmembrane conductance regulator	Mus musculus	129-133
31189070-9	2019	l-arginine uptake via SLC6A14 augmented F508del-CFTR function at baseline and after treatment with lumacaftor.	Arginine	0-10	solute carrier family 6 member 14	Homo sapiens	22-29
31189070-10	2019	SLC6A14-mediated l-arginine uptake also increased the airway surface liquid in CF-HBE cells.	Arginine	17-27	solute carrier family 6 member 14	Homo sapiens	0-7
31189070-12	2019	In summary, SLC6A14-mediated l-arginine transport augments residual F508del-CFTR channel function via a noncanonical, NO pathway.	Arginine	29-39	solute carrier family 6 member 14	Homo sapiens	12-19
31576512-17	2019	The protein expression levels of TJ proteins ZO-1 and claudin-1 were suppressed by heat stroke and dorsomorphin, but enhanced by L-arginine and AICAR.	Arginine	129-139	claudin 1	Rattus norvegicus	54-63
31340680-6	2019	Lysine restricted diet and arginine supplementation should be introduced in all the confirmed ALDH7A1 deficient patients.	Arginine	27-35	aldehyde dehydrogenase 7 family member A1	Homo sapiens	94-101
31533925-5	2019	Moreover, arginine methylation of the germ-cell-specific proteins Zili and Vasa, as well as histones H3 (H3R8me2s) and H4 (H4R3me2s), was reduced in the gonads of prmt5-null zebrafish.	Arginine	10-18	piwi-like RNA-mediated gene silencing 2	Danio rerio	66-70
31533925-8	2019	Our results revealed a novel mechanism associated with prmt5, i.e., prmt5 apparently controls germ cell development in vertebrates by catalyzing arginine methylation of the germline-specific proteins Zili and Vasa.	Arginine	145-153	piwi-like RNA-mediated gene silencing 2	Danio rerio	200-204
9127017-6	1997	The induced anti-dsDNA resembled spontaneous anti-DNA from autoimmune mice in V gene utilization and V(H) CDR3 arginine content.	Arginine	111-119	cerebellar degeneration-related 3	Mus musculus	106-110
31374327-10	2019	A base substitution mutation was identified at c.1466 (c.1466G&gt;T) of G6PD on chromosome X of the patient, which resulted in an amino acid change from arginine to leucine at p.489 (p.R489L).	Arginine	153-161	glucose-6-phosphate dehydrogenase	Homo sapiens	72-76
31240358-5	2019	So far, four acid resistance antiporters have been discovered, namely the glutamate-gamma-aminobutyric acid antiporter GadC, the arginine-agmatine antiporter AdiC, the lysine-cadaverine antiporter CadB, and the ornithine-putrescine antiporter PotE.	Arginine	129-137	POTE ankyrin domain family member D	Homo sapiens	243-247
9505357-1	1997	Phenylmethylsulfonyl fluoride (PMSF)-inhibited carboxypeptidase (CP) is recently described exopeptidase, that cleaved arginine residues from C-terminal of enkephalin synthetic analogs.	Arginine	118-126	proenkephalin	Rattus norvegicus	155-165
9108789-1	1997	A glutamine-for-arginine substitution at amino acid position 3500 of apolipoprotein B (apo B) causes synthesis of LDL with reduced binding affinity to the LDL receptor (LDLR).	Arginine	16-24	low density lipoprotein receptor	Homo sapiens	155-167
31464097-5	2019	RESULTS: We found a significant protective association between heterozygous GA genotype in ICAM1 (241Gly/Arg) and GBS (p < .047).	Arginine	105-108	intercellular adhesion molecule 1	Homo sapiens	91-96
9108789-1	1997	A glutamine-for-arginine substitution at amino acid position 3500 of apolipoprotein B (apo B) causes synthesis of LDL with reduced binding affinity to the LDL receptor (LDLR).	Arginine	16-24	low density lipoprotein receptor	Homo sapiens	169-173
9133593-0	1997	The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64.	Arginine	116-124	adrenoceptor beta 3	Macaca mulatta	4-29
31146155-9	2019	The LC-PCB sulfates formed hydrogen bond interaction with arginine 228 residue of TRalpha by their sulfate groups, which might facilitate the TR binding and agonistic activity.	Arginine	58-66	T cell receptor alpha locus	Homo sapiens	82-89
9131945-9	1997	Microsomes from yeast cells expressing CYP2D6 and from human lymphoblastoid cells expressing CYP3A4 or CYP2C9-Arg N-demethylated AMI, but those from cells expressing CYPs 1A2 and 2C19 did not.	Arginine	110-113	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109
31295473-13	2019	Interestingly, reciprocal inhibition experiments also supported by bioinformatics, suggested that glutamine and arginine may bind to different sites in the human SLC38A9 transporter.	Arginine	112-120	solute carrier family 38 member 9	Homo sapiens	162-169
9001236-2	1997	Mcm1 protein acts on a large number of distinctly regulated genes: haploid cell-type-specific genes, G2-cell-cycle-regulated genes, pheromone-induced genes, arginine metabolic genes, and genes important for cell wall and cell membrane function.	Arginine	157-165	transcription factor MCM1	Saccharomyces cerevisiae S288C	0-4
31390828-1	2019	Protein arginine methyltransferase 1 (PRMT1) can catalyze protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein arginine, which influences a variety of biological processes.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
31390828-1	2019	Protein arginine methyltransferase 1 (PRMT1) can catalyze protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein arginine, which influences a variety of biological processes.	Arginine	66-74	protein arginine methyltransferase 1	Homo sapiens	0-36
31390828-1	2019	Protein arginine methyltransferase 1 (PRMT1) can catalyze protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein arginine, which influences a variety of biological processes.	Arginine	66-74	protein arginine methyltransferase 1	Homo sapiens	38-43
31390828-4	2019	In the current manuscript, a series of 1-substituted 1H-tetrazole derivatives were designed and synthesized by targeting at the substrate arginine-binding site on PRMT1, and five compounds demonstrated significant inhibitory effects against PRMT1.	Arginine	138-146	protein arginine methyltransferase 1	Homo sapiens	163-168
8985064-6	1997	T-KGN levels were radioimmunoassayed; cathepsin B activity was assayed by using a synthetic substrate Z-Arg-Arg-MCA.	Arginine	104-107	cathepsin B	Rattus norvegicus	38-49
31390828-4	2019	In the current manuscript, a series of 1-substituted 1H-tetrazole derivatives were designed and synthesized by targeting at the substrate arginine-binding site on PRMT1, and five compounds demonstrated significant inhibitory effects against PRMT1.	Arginine	138-146	protein arginine methyltransferase 1	Homo sapiens	241-246
31390828-5	2019	The most potent PRMT1 inhibitor, compound 9a, displayed non-competitive pattern with respect to either SAM or substrate arginine, and showed the strong selectivity to PRMT1 compared to PRMT5, which belongs to the type II PRMT family.	Arginine	120-128	protein arginine methyltransferase 1	Homo sapiens	16-21
31366981-7	2019	Further analysis of the highly similar Cr-AGO2 and Cr-AGO 3 sequences (90% amino acid identity) revealed a glycine-arginine rich N-terminal extension of ~100 amino acids that, given previous work on unicellular protists, may associate AGO with the translation machinery.	Arginine	115-123	uncharacterized protein	Chlamydomonas reinhardtii	42-46
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	10-18	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	55-62
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	10-18	cytosolic arginine sensor for mTORC1 subunit 2	Homo sapiens	67-74
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	142-150	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	55-62
31305263-1	2019	Cytosolic arginine sensor for mTORC1 subunits 1 and 2 (CASTOR1 and CASTOR2) inhibit the mammalian target of rapamycin complex 1 (mTORC1) upon arginine deprivation.	Arginine	142-150	cytosolic arginine sensor for mTORC1 subunit 2	Homo sapiens	67-74
31295832-5	2019	Multistate structural modelling suggested that the E140Q substitution impeded an intrasubunit electrostatic interaction occurring between the E140 side chain in S2 and the arginine at position 210 in S4 (R210); this interaction is critically involved in stabilizing the activated configuration of the voltage-sensing domain (VSD) of Kv7.2.	Arginine	172-180	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	333-338
30515793-9	2019	However, administration of C-peptide or l-arginine significantly improved the pancreatic histopathology with a significant increase in the area % of insulin immunoreactivity, the number of PCNA immunopositive cells, the number of islets, and the diameter of islets compared with the diabetic group.	Arginine	40-50	proliferating cell nuclear antigen	Rattus norvegicus	189-193
30967626-3	2019	In the setting of mutant Kras, Mst1r overexpression increased acinar-ductal metaplasia (ADM), accelerated the progression of pancreatic intraepithelial neoplasia (PanIN), and resulted in the accumulation of (mannose receptor C type 1) MRC1+, (arginase 1) Arg+ macrophages in the tumor microenvironment.	Arginine	255-258	macrophage stimulating 1 receptor	Homo sapiens	31-36
10464642-4	1997	An exon 24 polymorphism of ATM, substituting arginine for proline was associated with breast cancer in these cases with an overall odds ratio of 4.5 (95% confidence interval, 1.2-20.5, nominal p = 0.02, 2-tail Fisher exact test).	Arginine	45-53	ATM serine/threonine kinase	Homo sapiens	27-30
9395248-1	1997	Nitric oxide (NO), first identified as endothelium-derived relaxing factor (EDRF), is a free radical synthesized from L-arginine by NO synthases (NOS).	Arginine	118-128	alpha hemoglobin stabilizing protein	Homo sapiens	39-74
30951406-7	2019	First, arginine-mediated stacking interactions promote AUF1"s helix-destabilizing RNA chaperone activity.	Arginine	7-15	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	55-59
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	111-119	transmembrane 4 L six family member 5	Homo sapiens	218-224
9395248-1	1997	Nitric oxide (NO), first identified as endothelium-derived relaxing factor (EDRF), is a free radical synthesized from L-arginine by NO synthases (NOS).	Arginine	118-128	alpha hemoglobin stabilizing protein	Homo sapiens	76-80
30861422-5	2019	To antagonize intracellular MDM2/MDMX for p53 activation, we extended this protein, PMIBcr/Abl, by a C-terminal Arg-repeating hexapeptide to facilitate its cellular uptake.	Arginine	112-115	MDM2 proto-oncogene	Homo sapiens	28-32
8940186-4	1996	We have found that the amino acids of ARNT that contact DNA are similar to those of other basic/helix-loop-helix proteins and include glutamic acid residue 83 and arginine residues 86 and 87.	Arginine	163-171	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	38-42
30861422-5	2019	To antagonize intracellular MDM2/MDMX for p53 activation, we extended this protein, PMIBcr/Abl, by a C-terminal Arg-repeating hexapeptide to facilitate its cellular uptake.	Arginine	112-115	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	91-94
30855197-10	2019	Presence of Arg/Gly or Gly/Gly genotypes in position 16 of ADRB2 was significantly associated to a worse BD response (post-BD FEV1: 108.68% +- 15.62% in Arg/Arg vs. 101.86% +- 14.03% in Arg/Gly or Gly/Gly patients, p = 0.02).	Arginine	12-15	adrenoceptor beta 2	Homo sapiens	59-64
8962059-4	1996	Energetically important binding contacts at the interface with TF were identified in the first epidermal growth factor domain of VIIa (Gln-64, Ile-69, Phe-71, Arg-79) and in the protease domain (Arg-277, Met-306, Asp-309).	Arginine	159-162	coagulation factor III, tissue factor	Homo sapiens	63-65
30855197-10	2019	Presence of Arg/Gly or Gly/Gly genotypes in position 16 of ADRB2 was significantly associated to a worse BD response (post-BD FEV1: 108.68% +- 15.62% in Arg/Arg vs. 101.86% +- 14.03% in Arg/Gly or Gly/Gly patients, p = 0.02).	Arginine	153-156	adrenoceptor beta 2	Homo sapiens	59-64
30855197-10	2019	Presence of Arg/Gly or Gly/Gly genotypes in position 16 of ADRB2 was significantly associated to a worse BD response (post-BD FEV1: 108.68% +- 15.62% in Arg/Arg vs. 101.86% +- 14.03% in Arg/Gly or Gly/Gly patients, p = 0.02).	Arginine	153-156	adrenoceptor beta 2	Homo sapiens	59-64
30855197-10	2019	Presence of Arg/Gly or Gly/Gly genotypes in position 16 of ADRB2 was significantly associated to a worse BD response (post-BD FEV1: 108.68% +- 15.62% in Arg/Arg vs. 101.86% +- 14.03% in Arg/Gly or Gly/Gly patients, p = 0.02).	Arginine	153-156	adrenoceptor beta 2	Homo sapiens	59-64
8962059-4	1996	Energetically important binding contacts at the interface with TF were identified in the first epidermal growth factor domain of VIIa (Gln-64, Ile-69, Phe-71, Arg-79) and in the protease domain (Arg-277, Met-306, Asp-309).	Arginine	195-198	coagulation factor III, tissue factor	Homo sapiens	63-65
8910598-0	1996	Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin.	Arginine	8-16	serpin family C member 1	Homo sapiens	76-88
30430339-5	2019	Additionally, bioinformatics analysis showed that BRCA2-tryptophan &gt; arginine substitutions result in altered interaction of BRCA1/PALB2/BRCA2/protein complex and impaired HDDR pathway.	Arginine	72-80	BRCA2 DNA repair associated	Homo sapiens	50-55
30430339-5	2019	Additionally, bioinformatics analysis showed that BRCA2-tryptophan &gt; arginine substitutions result in altered interaction of BRCA1/PALB2/BRCA2/protein complex and impaired HDDR pathway.	Arginine	72-80	BRCA1 DNA repair associated	Homo sapiens	128-133
30430339-5	2019	Additionally, bioinformatics analysis showed that BRCA2-tryptophan &gt; arginine substitutions result in altered interaction of BRCA1/PALB2/BRCA2/protein complex and impaired HDDR pathway.	Arginine	72-80	partner and localizer of BRCA2	Homo sapiens	134-139
30430339-5	2019	Additionally, bioinformatics analysis showed that BRCA2-tryptophan &gt; arginine substitutions result in altered interaction of BRCA1/PALB2/BRCA2/protein complex and impaired HDDR pathway.	Arginine	72-80	BRCA2 DNA repair associated	Homo sapiens	140-145
8913624-2	1996	Linear and cyclic forms of the fibronectin (Fn) cell-binding domain peptide Arg-Gly-Asp (RGD) were covalently immobilized to glass, and Fn was adsorbed onto glass slides.	Arginine	76-79	fibronectin 1	Bos taurus	31-42
8913624-2	1996	Linear and cyclic forms of the fibronectin (Fn) cell-binding domain peptide Arg-Gly-Asp (RGD) were covalently immobilized to glass, and Fn was adsorbed onto glass slides.	Arginine	76-79	fibronectin 1	Bos taurus	44-46
31040342-2	2019	Endothelial nitric oxide synthase (eNOS), an enzyme that synthesizes nitric oxide (NO) by converting L-arginine to L-citrulline, is highly concentrated in plasma membrane caveolae.	Arginine	101-111	nitric oxide synthase 3	Rattus norvegicus	0-33
31040342-2	2019	Endothelial nitric oxide synthase (eNOS), an enzyme that synthesizes nitric oxide (NO) by converting L-arginine to L-citrulline, is highly concentrated in plasma membrane caveolae.	Arginine	101-111	nitric oxide synthase 3	Rattus norvegicus	35-39
8938428-6	1996	This mutation results in an arginine to STOP alteration at amino acid 241, predicting premature termination of cathepsin K mRNA translation.	Arginine	28-36	cathepsin K	Homo sapiens	111-122
31013889-4	2019	In this study, the (pI)DPhe position of the tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 (an MC3R agonist/MC4R antagonist ligand) was investigated with a library of 12 compounds.	Arginine	64-67	melanocortin 3 receptor	Mus musculus	89-93
8959637-8	1996	Pretreating the samples with arginine decreased or abolished immunofluorescence staining for PAI-1 and t-PA, but not for VN.	Arginine	29-37	serpin family E member 1	Homo sapiens	93-98
30783866-8	2019	Arg or Asp was identified as a catalytic site in plasmodium IspD homologs, contributing a direct role in the cytidylyltransferase activity similar to bacterial IspD.	Arginine	0-3	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	60-64
30674553-7	2019	We also identified a yeast DNA repair protein, MQ-Rad16, bearing a Met-Gln N terminus, as well as a human tropomyosin-receptor kinase-fused gene (TFG) protein, MN-TFG, bearing a Met-Asn N terminus as physiological, MetAP-processed Arg/N-end rule substrates.	Arginine	231-234	trafficking from ER to golgi regulator	Homo sapiens	146-149
8930296-2	1996	This is the first in vivo electrophysiological evidence demonstrating the effects of Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln (nociceptin or orphanin FQ), an endogenous ligand for the orphan ORL1 receptor, on nociceptive neurons in the CNS.	Arginine	113-116	prepronociceptin	Rattus norvegicus	154-164
30276801-6	2019	The missense mutation locates in the C-terminal domain of SYNM and leads to a substitution of tryptophan by arginine and may cause the structure change of synemin protein.	Arginine	108-116	synemin	Homo sapiens	58-62
30276801-6	2019	The missense mutation locates in the C-terminal domain of SYNM and leads to a substitution of tryptophan by arginine and may cause the structure change of synemin protein.	Arginine	108-116	synemin	Homo sapiens	155-162
8930296-2	1996	This is the first in vivo electrophysiological evidence demonstrating the effects of Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln (nociceptin or orphanin FQ), an endogenous ligand for the orphan ORL1 receptor, on nociceptive neurons in the CNS.	Arginine	113-116	prepronociceptin	Rattus norvegicus	168-179
8900394-6	1996	In one case, the Arg residue of the reference peptide corresponding to R129 of ATIII has been replaced by Gln (R129deltaQ peptide), thus mimicking the naturally occurring mutant protein, ATIII Geneva.	Arginine	17-20	serpin family C member 1	Homo sapiens	79-84
8900395-10	1996	Arginines 48 and 68 of desmin"s head domain were shown to be sites of modification, with arginine 48 the major ADP-ribosylation site.	Arginine	0-9	desmin	Homo sapiens	23-29
8900395-10	1996	Arginines 48 and 68 of desmin"s head domain were shown to be sites of modification, with arginine 48 the major ADP-ribosylation site.	Arginine	89-97	desmin	Homo sapiens	23-29
30626204-9	2019	Knockdown of c-ABL/ARG in HUVEC-TIE2-L914F reduced cell proliferation and vascularity of murine VM.	Arginine	19-22	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	13-18
8826971-2	1996	A tryptophan to arginine (Trp64Arg) mutation in the beta 3-adrenergic receptor (beta 3-AR) gene has been implicated in diabetes and obesity.	Arginine	16-24	adrenoceptor beta 3	Homo sapiens	52-78
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	142-149
30639019-12	2019	In addition, compared with the control, supply of Met or Arg upregulated genes related to transcription and translation (MAPK1, MTOR, SREBF1, RPS6KB1, JAK2), insulin signaling (AKT2, IRS1), AA transport (SLC1A5, SLC7A1), and cell proliferation (MKI67).	Arginine	57-60	antigen identified by monoclonal antibody Ki 67	Mus musculus	245-250
8826971-2	1996	A tryptophan to arginine (Trp64Arg) mutation in the beta 3-adrenergic receptor (beta 3-AR) gene has been implicated in diabetes and obesity.	Arginine	16-24	adrenoceptor beta 3	Homo sapiens	80-89
30783097-7	2019	We speculate that reduced PRMT5 expression during infection may lead to reduced arginine methylation of AGO2, resulting in accumulation of both AGO2 and, via reduced interaction with TSNs, accumulation of AGO2-associated sRNAs, to promote plant immunity.	Arginine	80-88	SHK1 binding protein 1	Arabidopsis thaliana	26-31
30783097-8	2019	These results reveal that both the arginine methylation writer (PRMT5) and readers (TSNs) can regulate AGO2-mediated RNAi.	Arginine	35-43	SHK1 binding protein 1	Arabidopsis thaliana	64-69
8823359-11	1996	Treatment with L-arginine, on the other hand increased the production of interleukin-2 and interferon-gamma.	Arginine	15-25	interleukin 2	Mus musculus	73-86
30685970-8	2019	The results showed that Arg promoted the protein expression of Nrf2, up-regulated expression of the phase II metabolizing enzymes (NQO1 and HO-1), as well as antioxidative enzymes (GPx1, CAT, and SOD2) for alleviating oxidative injury and protected IOECs from LPS-induced apoptosis.	Arginine	24-27	glutathione peroxidase 1	Homo sapiens	181-185
8855288-0	1996	Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine.	Arginine	90-98	major histocompatibility complex, class I, B	Homo sapiens	9-16
30567733-6	2019	Furthermore, a K313 to arginine mutation of RORgammat (RORgammat-K313R), which disrupts the interaction of RORgammat with SRC3 but not with SRC1, impairs Th17 differentiation but not thymocyte development.	Arginine	23-31	nuclear receptor coactivator 3	Mus musculus	122-126
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	123-133	dominant cataract 2	Mus musculus	56-60
30202097-1	2019	Solute carrier family 7 member 2 (SLC7A2, also known as CAT2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in wound repair.	Arginine	135-140	dominant cataract 2	Mus musculus	56-60
8855288-1	1996	The class I major histocompatibility complex (MHC) glycoprotein HLA-B27 binds short peptides containing arginine at peptide position 2 (P2).	Arginine	104-112	major histocompatibility complex, class I, B	Homo sapiens	64-71
8855288-3	1996	Based on the three-dimensional structure of HLA-B27, we have synthesized a ligand with an aziridine-containing side chain designed to mimic arginine and to bind covalently in the arginine-specific P2 pocket of HLA-B27.	Arginine	140-148	major histocompatibility complex, class I, B	Homo sapiens	44-51
8855288-3	1996	Based on the three-dimensional structure of HLA-B27, we have synthesized a ligand with an aziridine-containing side chain designed to mimic arginine and to bind covalently in the arginine-specific P2 pocket of HLA-B27.	Arginine	179-187	major histocompatibility complex, class I, B	Homo sapiens	44-51
8855288-3	1996	Based on the three-dimensional structure of HLA-B27, we have synthesized a ligand with an aziridine-containing side chain designed to mimic arginine and to bind covalently in the arginine-specific P2 pocket of HLA-B27.	Arginine	179-187	major histocompatibility complex, class I, B	Homo sapiens	210-217
30446621-8	2019	In rat GP70, we identified the positively charged Arg-130 as the binding site.	Arginine	50-53	embigin L homeolog	Xenopus laevis	7-11
8902879-1	1996	Treatment of bovine aortic endothelial cells with tumor necrosis factor-alpha (TNF-alpha) resulted in a concentration-dependent increase in L-arginine transport.	Arginine	140-150	tumor necrosis factor	Bos taurus	50-77
8902879-1	1996	Treatment of bovine aortic endothelial cells with tumor necrosis factor-alpha (TNF-alpha) resulted in a concentration-dependent increase in L-arginine transport.	Arginine	140-150	tumor necrosis factor	Bos taurus	79-88
30543107-5	2019	Pathway analysis demonstrated that several metabolic pathways such as aminoacyl-tRNA biosynthesis, arginine and proline metabolism, and phenylalanine, tyrosine, and tryptophan biosynthesis were dysregulated in apoA-I knockout mice.	Arginine	99-107	apolipoprotein A-I	Mus musculus	210-216
8902879-3	1996	Both actinomycin D and cycloheximide inhibited the TNF-alpha mediated increase in L-arginine transport, indicating that de novo RNA and protein synthesis were required.	Arginine	82-92	tumor necrosis factor	Bos taurus	51-60
8799112-3	1996	In this paper we show that all of the phosphorylated, mAb 104 detectable, Ser/Arg-rich essential splicing factors (SR proteins) in the nucleoplasm are integral components of the InRNP particles, whereas only part of the essential splicing factor U2AF65 (U2 snRNP auxiliary factor) and the polypyrimidine tract binding protein (PTB) are associated with these particles.	Arginine	78-81	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	246-252
30513135-1	2019	Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues.	Arginine	8-16	protein arginine methyltransferase 7	Homo sapiens	38-43
8698354-4	1996	The deletions reported here would result in severe disruptions of the ATM gene product by leading either to a protein truncation (a 4-bp deletion) or the loss of stretches of 53 and 58 amino acids (a 159-bp deletion and a 174-bp deletion, respectively); whereas the base substitution would lead to an amino acid change from a highly conserved glycine to an arginine residue.	Arginine	357-365	ATM serine/threonine kinase	Homo sapiens	70-73
30290711-3	2019	We recently found that SQSTM1 is a novel type of N-recognin whose ZZ domain provides a negatively-charged binding pocket for Arg-charged N-degron (Nt-Arg), a prototype type-1 substrate.	Arginine	125-128	sequestosome 1	Homo sapiens	23-29
8776903-7	1996	The deduced amino acid (427 residues) sequence from the short transcript has strong homology to the animal U1-70K protein and contains an RNA recognition motif, a glycine hinge, and an arginine-rich region characteristic of the animal U1-70K protein.	Arginine	185-193	U1 small nuclear ribonucleoprotein-70K	Arabidopsis thaliana	107-113
8776903-7	1996	The deduced amino acid (427 residues) sequence from the short transcript has strong homology to the animal U1-70K protein and contains an RNA recognition motif, a glycine hinge, and an arginine-rich region characteristic of the animal U1-70K protein.	Arginine	185-193	U1 small nuclear ribonucleoprotein-70K	Arabidopsis thaliana	235-241
8663387-4	1996	beta3 is a polymorphic variant at ADH2 that differs from beta1 by a single amino acid substitution of Arg-369 --&gt; Cys.	Arginine	102-105	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	0-5
30414414-2	2019	A mutation (m.9176 T &gt; G) of the mitochondrial ATP6 gene that replaces an universally conserved leucine residue into arginine at amino acid position 217 of human subunit a (aL217R) has been associated to NARP (Neuropathy, Ataxia and Retinitis Pigmentosa) and MILS (Maternally Inherited Leigh"s Syndrome) diseases.	Arginine	120-128	neuronal pentraxin 2	Homo sapiens	207-211
8663387-7	1996	The three-dimensional structures of beta3 and beta1 are virtually identical, with the exception that Cys-369 and two water molecules in beta3 occupy the position of Arg-369 in beta1.	Arginine	165-168	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-51
8663387-7	1996	The three-dimensional structures of beta3 and beta1 are virtually identical, with the exception that Cys-369 and two water molecules in beta3 occupy the position of Arg-369 in beta1.	Arginine	165-168	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	36-41
8652789-7	1996	The nmr pattern for 3 showed a remarkable similarity with that for various Arg-Tyr-Asp containing peptides, a sequence that is crucial for the adhesion properties of the Leishmania gp63 glycoprotein.	Arginine	75-78	leishmanolysin like peptidase	Homo sapiens	181-185
30526045-0	2019	Discovery of arginine-containing tripeptides as a new class of pancreatic lipase inhibitors.	Arginine	13-21	pancreatic lipase	Homo sapiens	63-80
30467244-7	2019	RESULTS: The TP53 codon 72 Pro allele and the XRCC1 codon 399 Arg allele in a homozygous state were associated with lung adenocarcinoma (p=0.037; OR (95% CI) 2.42 (1.10 to 5.31)), that is, p=0.037; OR (95% CI) 2.16 (1.08 to 4.33), respectively.	Arginine	62-65	X-ray repair cross complementing 1	Homo sapiens	46-51
29923088-2	2019	To date, eight cases had been published worldwide, all with heterozygous missense variants at the allosteric site, specifically at Arginine 294 (formerly 263) and Arginine 297 (formerly 266) of GNE.	Arginine	163-171	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	194-197
30352217-5	2018	We observed that cdk8 and cycC mutants are sensitive to the levels of dietary proteins and seven amino acids (arginine, glutamine, isoleucine, leucine, methionine, threonine, and valine).	Arginine	110-118	Cyclin C	Drosophila melanogaster	26-30
30446222-5	2018	Mechanistically, we demonstrated that LINC01138 interacts with PRMT5 to increase arginine methylation and protein stability of SREBP1, promoting lipid desaturation and cell proliferation in ccRCC.	Arginine	81-89	long intergenic non-protein coding RNA 1138	Homo sapiens	38-47
30230223-5	2018	We highlighted how a random binary, ordered ternary kinetic model for PRMT1 catalysis reconciles the literature reports and endorses a distributive mechanism that the enzyme active site utilizes for multiple turnovers of arginine methylation.	Arginine	221-229	protein arginine methyltransferase 1	Homo sapiens	70-75
30420520-0	2018	Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis.	Arginine	0-8	sirtuin 7	Mus musculus	24-29
30420520-4	2018	Here, we report that SIRT7 is methylated at arginine 388 (R388), which inhibits its H3K18 deacetylase activity.	Arginine	44-52	sirtuin 7	Mus musculus	21-26
30420520-10	2018	Together, PRMT6-induced arginine methylation of SIRT7 coordinates glucose availability with mitochondria biogenesis to maintain energy homeostasis.	Arginine	24-32	sirtuin 7	Mus musculus	48-53
30420520-11	2018	Our study uncovers the regulatory role of SIRT7 arginine methylation in glucose sensing and mitochondria biogenesis.	Arginine	48-56	sirtuin 7	Mus musculus	42-47
30267546-8	2018	Twenty-eight recreationally active men (mean +- SD 23.1 +- 1.3 years of age) were genotyped for Arg16Gly polymorphisms of beta2 -AR as arginine homozygous (ArgArg; n = 5), glycine homozygous (GlyGly; n = 11) or arginine-glycine heterozygous (ArgGly; n = 12).	Arginine	135-143	adrenoceptor beta 2	Homo sapiens	122-131
30281865-2	2018	A common null polymorphism in the ACTN3 gene (rs1815739:C&gt;T) results in replacement of an arginine (R) with a premature stop codon (X) at amino acid 577 in the fast muscle protein alpha-actinin-3.	Arginine	93-101	actinin alpha 3	Homo sapiens	34-39
30281865-2	2018	A common null polymorphism in the ACTN3 gene (rs1815739:C&gt;T) results in replacement of an arginine (R) with a premature stop codon (X) at amino acid 577 in the fast muscle protein alpha-actinin-3.	Arginine	93-101	actinin alpha 3	Homo sapiens	183-198
30206180-7	2018	In vitro, we showed that transcription factor Pho4p can be methylated at Arg-241, which could explain phosphate dysregulation in hmt1Delta if interplay exists with phosphorylation at Ser-242 or Ser-243, or if Arg-241 methylation affects the capacity of Pho4p to homodimerize or interact with Pho2p.	Arginine	73-76	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	46-51
30206180-7	2018	In vitro, we showed that transcription factor Pho4p can be methylated at Arg-241, which could explain phosphate dysregulation in hmt1Delta if interplay exists with phosphorylation at Ser-242 or Ser-243, or if Arg-241 methylation affects the capacity of Pho4p to homodimerize or interact with Pho2p.	Arginine	73-76	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	253-258
30206180-7	2018	In vitro, we showed that transcription factor Pho4p can be methylated at Arg-241, which could explain phosphate dysregulation in hmt1Delta if interplay exists with phosphorylation at Ser-242 or Ser-243, or if Arg-241 methylation affects the capacity of Pho4p to homodimerize or interact with Pho2p.	Arginine	209-212	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	46-51
30496303-8	2018	Both proteins were shown to interact with the triple arginine motif, and confocal fluorescence microscopy revealed that their simultaneous depletion resulted in diminished MX2 accumulation at the nuclear envelope.	Arginine	53-61	MX dynamin like GTPase 2	Homo sapiens	172-175
30287686-9	2018	Finally, we identified a conserved catalytic ensemble comprising Glu-646 and Arg-604 that supports HECT-ubiquitin thioester exchange and isopeptide bond formation at the active-site Cys-922 of NEDD4-2.	Arginine	77-80	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	193-200
30257864-4	2018	Biochemical assays revealed that coactivator-associated arginine methyltransferase 1 (CARM1) interacts directly with and methylates PRMT5 at Arg-505 both in vivo and in vitro.	Arginine	141-144	coactivator associated arginine methyltransferase 1	Homo sapiens	33-84
30257864-4	2018	Biochemical assays revealed that coactivator-associated arginine methyltransferase 1 (CARM1) interacts directly with and methylates PRMT5 at Arg-505 both in vivo and in vitro.	Arginine	141-144	coactivator associated arginine methyltransferase 1	Homo sapiens	86-91
30007131-10	2018	Number of POMC neuronal cells in the arcuate nucleus (ARC) of the hypothalamus decreased (P &lt;= 0.03) in the Res group compared with Res-Arg.	Arginine	139-142	pro-opiomelanocortin	Ovis aries	10-14
30007131-13	2018	Numbers of POMC-containing cells were increased in the ARC in lambs from ewes restricted to 60% of nutritional requirements and supplemented with rumen-protected arginine, potentially influencing feeding behavior and hepatic energy metabolism.	Arginine	162-170	pro-opiomelanocortin	Ovis aries	11-15
29497956-1	2018	PURPOSE: This study aimed to investigate the value of 99mtechnetium-three polyethylene glycol spacers-arginine-glycine-aspartic acid ([99mTc]3PRGD2) imaging in diagnosis and staging of breast cancer compared with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) imaging, and to explore the expression of integrin alphavbeta3 in tumor vascular endothelial cells.	Arginine	102-110	integrin subunit alpha V	Homo sapiens	298-318
30173511-5	2018	Moreover, CMH and GAA supplementation increased the concentrations of creatine and phosphocreatine and the mRNA expressions of guanidinoacetate N-methyltransferase and creatine transporter in longissimus dorsi muscle, semitendinosus muscle, liver, or kidneys and decreased the mRNA expressions of arginine:glycine amidinotransferase in kidneys.	Arginine	297-305	alpha glucosidase	Sus scrofa	18-21
29447112-2	2018	CDCP1 is cleaved by serine proteases at adjacent sites, arginine 368 (R368) and lysine 369 (K369), which induces cell migration in vitro and metastasis in vivo.	Arginine	56-64	CUB domain containing protein 1	Homo sapiens	0-5
30456381-5	2018	We identified the major CARM1-mediated MED12 methylation site as arginine 1899 (R1899), which interacts with the Tudor domain-containing effector molecule, TDRD3.	Arginine	65-73	coactivator associated arginine methyltransferase 1	Homo sapiens	24-29
30232003-4	2018	CARM1 methylates GAPDH at arginine 234 (R234), inhibiting its catalytic activity.	Arginine	26-34	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
29878441-6	2018	The crystal structure of KDM6B in complex with a histone 3 derived K18I peptide reveals a tighter fit of the isoleucine side chain, compared with that of the arginine.	Arginine	158-166	lysine demethylase 6B	Homo sapiens	25-30
30042193-6	2018	Comparisons of gene expression profiles in kidney tissues at P22 and P30 in PKD and WT mice revealed that arginine metabolism was significantly activated; 204 differentially expressed genes (DEGs), including Arg1, an arginine metabolism-associated gene, were identified in late-stage polycystic kidneys.	Arginine	106-114	protein kinase D1	Mus musculus	76-79
30200364-3	2018	Recently, we computationally showed by the B3LYP density functional theory method, that inorganic phosphate and the Arg side chain can catalyze the NGR deamidation using a cyclic peptide, c[CH2CO-NGRC]-NH2.	Arginine	116-119	reticulon 4 receptor	Homo sapiens	148-151
30161253-1	2018	OBJECTIVE: Peptidylarginine deiminase 2 (PAD2) and PAD4 are expressed in the synovium of rheumatoid arthritis (RA) patients and catalyze citrullination of arginine residues in proteins targeted by anti-citrullinated protein antibodies (ACPAs).	Arginine	19-27	peptidyl arginine deiminase 2	Homo sapiens	41-45
29967243-8	2018	Point mutations within the PBD, including arginine-to-lysine substitutions, profoundly alter Rac1 lipid binding specificity without changing the electrostatics of the protein and result in impaired macropinocytosis and decreased cell spreading.	Arginine	42-50	Rac family small GTPase 1	Homo sapiens	93-97
30022074-0	2018	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy.	Arginine	34-42	nucleoporin 62	Homo sapiens	25-28
30022074-4	2018	This requires p62 to associate via the Tudor protein SMN with proteins, including FUS, that are symmetrically methylated on arginines.	Arginine	124-133	nucleoporin 62	Homo sapiens	14-17
30022074-5	2018	Mice lacking p62 accumulate arginine-methylated proteins and alterations in FUS-dependent splicing.	Arginine	28-36	nucleoporin 62	Mus musculus	13-16
30022074-6	2018	Patients with C9ORF72 repeat expansions accumulate symmetric arginine dimethylated proteins which co-localize with p62.	Arginine	61-69	nucleoporin 62	Homo sapiens	115-118
29746817-5	2018	The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway.	Arginine	26-34	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	237-241
29746817-5	2018	The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-gamma, including reducing cell proliferation, cell migration and colony formation, through the NF-kappaB-GCN2/eIF2alpha pathway.	Arginine	26-34	eukaryotic translation initiation factor 2A	Homo sapiens	242-251
29983416-5	2018	Using in silico experiments, we identified interface polar residue Asp-354 of p38 and Arg-492, Arg-496 of TRF2 as protein-protein interaction hotspots.	Arginine	86-89	telomeric repeat binding factor 2	Homo sapiens	106-110
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Arginine	63-66	fibronectin 1	Gallus gallus	14-25
29983416-5	2018	Using in silico experiments, we identified interface polar residue Asp-354 of p38 and Arg-492, Arg-496 of TRF2 as protein-protein interaction hotspots.	Arginine	95-98	telomeric repeat binding factor 2	Homo sapiens	106-110
29983416-6	2018	In addition to these interactions, Arg-49 residue of p38 was also found to interact with Glu-456 of TRF2.	Arginine	35-38	telomeric repeat binding factor 2	Homo sapiens	100-104
8725286-4	1996	Inhibition of fibronectin matrix formation by the inclusion of Arg-Gly-Asp-containing peptides, which compete with fibronectin for binding to the cell surface alpha 5 beta 1 integrin receptors, abolished the proliferation effects of FGF-2.	Arginine	63-66	fibronectin 1	Gallus gallus	115-126
8743501-2	1996	Subsequent studies revealed that EDRF is NO, and is synthesized by mammalian cells from L-arginine through a complex oxidation reaction catalyzed by the flavo-hemoprotein NO synthase (NOS).	Arginine	88-98	alpha hemoglobin stabilizing protein	Homo sapiens	33-37
8647861-13	1996	NP220 has an arginine/serine-rich domain commonly found in pre-mRNA splicing factors.	Arginine	13-21	zinc finger protein 638	Homo sapiens	0-5
29780003-3	2018	METHODS/RESULTS: Here we provide evidence that the disease-associated apoptosis-inducing factor (AIF) deletion arginine 201 (R200 in rodents) causes pathology in knockin mice.	Arginine	111-119	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	70-95
29780003-3	2018	METHODS/RESULTS: Here we provide evidence that the disease-associated apoptosis-inducing factor (AIF) deletion arginine 201 (R200 in rodents) causes pathology in knockin mice.	Arginine	111-119	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	97-100
8662674-5	1996	Following a 24-h exposure to IL-1beta and IFNgamma, arginine uptake increases Vmax = 167 pmol/2 X 10(5) cells/min) and a second low-affinity L-arginine transporter activity appears (Km = 1.2 mM).	Arginine	52-60	interferon gamma	Rattus norvegicus	42-50
29773710-9	2018	The enzyme PRMT1 was found to be essential for Wnt-stimulated arginine methylation, GSK3 sequestration, and canonical Wnt signaling.	Arginine	62-70	protein arginine methyltransferase 1	Homo sapiens	11-16
29773710-10	2018	The results reveal a cell biological role for PRMT1 arginine methylation at the crossroads of growth factor signaling, protein phosphorylation, membrane trafficking, cytosolic proteolysis, and Wnt-regulated microautophagy.	Arginine	52-60	protein arginine methyltransferase 1	Homo sapiens	46-51
8635257-4	1996	A single nucleotide substitution of thymidine to guanine (T1961G) changed the coding sense of HERG from isoleucine to arginine (Ile593Arg) in the channel pore region.	Arginine	118-126	potassium voltage-gated channel subfamily H member 2	Homo sapiens	94-98
8928839-0	1996	Effect of L-arginine on myoglobin-induced acute renal failure in the rabbit.	Arginine	10-20	LOW QUALITY PROTEIN: myoglobin	Oryctolagus cuniculus	24-33
29928487-8	2018	Nucleolin directly bound to TRA2beta4 exon 2 via the glycine/arginine-rich (GAR) domain.	Arginine	61-69	transformer 2 beta homolog	Homo sapiens	28-36
8928839-5	1996	This study suggests that the myoglobin-induced renal vasoconstriction and dysfunction and protective effect of L-arginine on these outcomes could be mediated through the NO system.	Arginine	111-121	LOW QUALITY PROTEIN: myoglobin	Oryctolagus cuniculus	29-38
8647188-4	1996	In the present study, using NOD (I-Ag7) mice, we established a T cell hybridoma specific for a p43-58 analog 46R50E54A with arginine (R) and alanine (A) at positions 46 and 54, respectively.	Arginine	124-132	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	Mus musculus	95-98
8621785-5	1996	After oral L-arginine, plasma L-arginine levels rose from 115+/-103 to 231+/-125 micromol/liter (P&lt;0.001), and EDD improved from 1.7+/-1.3 to 5.6+/-3.0% (P&lt;0.001).	Arginine	11-21	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	114-117
8621785-9	1996	Dietary supplementation with L-arginine significantly improves EDD in hypercholesterolemic young adults, and this may impact favorably on the atherogenic process.	Arginine	29-39	ubiquitin protein ligase E3 component n-recognin 5	Homo sapiens	63-66
8792089-8	1996	They cleave selectively at Lys-Arg or Arg-Arg sites in precursors, generating products with C-terminal basic residues that are then removed by carboxypeptidase E, an exopeptidase.	Arginine	31-34	carboxypeptidase E	Homo sapiens	143-161
8792089-8	1996	They cleave selectively at Lys-Arg or Arg-Arg sites in precursors, generating products with C-terminal basic residues that are then removed by carboxypeptidase E, an exopeptidase.	Arginine	38-41	carboxypeptidase E	Homo sapiens	143-161
8671633-2	1996	In common for all these peptides is the core sequence NH2-Ser-Arg-Tyr-Trp-Ala-Ile-Arg-Thr-Arg-COOH, NP383-391, known as an antigenic peptide specific for the HLA-B27 class I antigen.	Arginine	62-65	major histocompatibility complex, class I, B	Homo sapiens	158-165
8671633-2	1996	In common for all these peptides is the core sequence NH2-Ser-Arg-Tyr-Trp-Ala-Ile-Arg-Thr-Arg-COOH, NP383-391, known as an antigenic peptide specific for the HLA-B27 class I antigen.	Arginine	82-85	major histocompatibility complex, class I, B	Homo sapiens	158-165
8671633-2	1996	In common for all these peptides is the core sequence NH2-Ser-Arg-Tyr-Trp-Ala-Ile-Arg-Thr-Arg-COOH, NP383-391, known as an antigenic peptide specific for the HLA-B27 class I antigen.	Arginine	82-85	major histocompatibility complex, class I, B	Homo sapiens	158-165
8636149-7	1996	In contrast, CHO cells expressing an insulin receptor mutated at the ATP binding site (Lys-1030 --&gt; Arg) showed no insulin-stimulated autophosphorylation or phosphorylation of IRS-1.	Arginine	103-106	insulin receptor	Cricetulus griseus	37-53
8638661-10	1996	These results indicate that the L-arginine-NO system may contribute to the regulation of EGF receptor expression in developing granulosa cells stimulated by FSH.	Arginine	32-42	epidermal growth factor	Rattus norvegicus	89-92
8643658-1	1996	The L-arginine:nitric oxide (NO) pathway is believed to exert many of its physiological effects via stimulation of the soluble guanylyl cyclase (SGC); however, the lack of a selective inhibitor of this enzyme has prevented conclusive demonstration of this mechanism of action.	Arginine	4-14	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	145-148
8852756-0	1996	Probing structure-activity relationship in diamine oxidase--reactivities of lysine and arginine residues.	Arginine	87-95	amine oxidase copper containing 1	Sus scrofa	43-58
8852756-1	1996	Lysine and arginine residues of pig kidney diamine oxidase (DAO) were modified with 2,4,6-trinitrobenzenesulphonic acid (TNBS), 2,3-butanedione and phenylglyoxal, respectively, using different concentrations and time periods.	Arginine	11-19	amine oxidase copper containing 1	Sus scrofa	43-58
8852756-1	1996	Lysine and arginine residues of pig kidney diamine oxidase (DAO) were modified with 2,4,6-trinitrobenzenesulphonic acid (TNBS), 2,3-butanedione and phenylglyoxal, respectively, using different concentrations and time periods.	Arginine	11-19	amine oxidase copper containing 1	Sus scrofa	60-63
8636301-10	1996	N omega-nitro-L-arginine (100 mumol/L) increased placental CRH-IR secretion into fetal perfusate, and this effect was reversed by the infusion of L-arginine (100 mumol/L), which also reduced release below basal levels.	Arginine	14-24	corticotropin releasing hormone	Homo sapiens	59-62
8551576-2	1996	Molecular cloning and sequencing of the v-myc gene revealed several unique mutations, including a large deletion affecting amino acids 49 to 124 and a 3-bp insertion within the basic DNA binding domain which converts Leu-362 to Phe-Arg.	Arginine	232-235	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-45
8903674-3	1996	Pretreatment with 30 mg/kg of NG-nitro-L-arginine methylester (L-NAME), an inhibitor of NO synthase, accelerated increases of the TBARS level and myeloperoxidase (MPO) activity in the injured tissue and caused deterioration of hind limb motor function after SCI, suggesting that NO formation by constitutive NO synthase (c-NOS) has a protective effect against cellular damage resulting from ischemia-reperfusion after SCI.	Arginine	41-49	myeloperoxidase	Rattus norvegicus	146-161
8903674-3	1996	Pretreatment with 30 mg/kg of NG-nitro-L-arginine methylester (L-NAME), an inhibitor of NO synthase, accelerated increases of the TBARS level and myeloperoxidase (MPO) activity in the injured tissue and caused deterioration of hind limb motor function after SCI, suggesting that NO formation by constitutive NO synthase (c-NOS) has a protective effect against cellular damage resulting from ischemia-reperfusion after SCI.	Arginine	41-49	myeloperoxidase	Rattus norvegicus	163-166
8557254-4	1996	In E-selectin, exchanges from serine to arginine (position 128), from leucine to phenylalanine (position 554), and a DNA mutation from guanine to thymine (position 98) present significantly different allele frequencies in young patients with angiographically established, severe atherosclerosis, compared with an unselected population.	Arginine	40-48	selectin E	Homo sapiens	3-13
8835314-5	1996	Moreover, the immortalized cells retained the ability to express the functional specific amino acid Na(+)-independent system Y+ transporter, which mediates L-arginine transport into endothelial cells from which endothelium-derived relaxing factor (EDRF, nitric oxide) is formed via the action of nitric oxide-synthase.	Arginine	156-166	alpha hemoglobin stabilizing protein	Homo sapiens	211-246
8835314-5	1996	Moreover, the immortalized cells retained the ability to express the functional specific amino acid Na(+)-independent system Y+ transporter, which mediates L-arginine transport into endothelial cells from which endothelium-derived relaxing factor (EDRF, nitric oxide) is formed via the action of nitric oxide-synthase.	Arginine	156-166	alpha hemoglobin stabilizing protein	Homo sapiens	248-252
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Arginine	64-67	fibronectin 1	Mus musculus	94-105
8979267-1	1996	The partially modified retro- and retro-inverso peptides of the Arg-Gly Asp (RGD) sequence of fibronectin, in which the direction of the Arg residue is reversed and/or the chirality of the amino acid residue is inverted, i.e., mainly R(rev)-COCH2CO-D and DR(rev)-COCH2CO-D, have been synthesized to examine their antimetastatic effects in murine lung or liver metastasis models, as well as their inhibitory effect on tumor cell invasion in vitro.	Arginine	137-140	fibronectin 1	Mus musculus	94-105
8804070-7	1996	The anti-NPFF activity of 15 mg/kg L-NNA was blocked by 750 mg/kg L-arginine, but not by the same amount of D-arginine, indicating that L-NNA attenuates NPFF activity through a stereospecific inhibition of NOS.	Arginine	66-76	neuropeptide FF-amide peptide precursor	Rattus norvegicus	9-13
8554571-0	1995	A novel mutation substituting tryptophan with arginine in the carboxyl-terminal, non-collagenous domain of collagen X in a case of Schmid metaphyseal chondrodysplasia.	Arginine	46-54	collagen type X alpha 1 chain	Homo sapiens	131-166
7495285-6	1995	Six MEN-2A-associated hyperplastic glands exhibited identical band shifts in the polymerase chain reaction single-strand conformation polymorphism analysis of exon 11, which corresponded to a Cys 634--&gt;Arg substitution in the nucleotide sequence analysis (TGC--&gt;CGC), whereas in the MEN 2B parathyroid specimen a point mutation was found at codon 918 of exon 16 (ATG--&gt;ACG), causing a Met 918--&gt;Thr substitution.	Arginine	205-208	ret proto-oncogene	Homo sapiens	4-10
7495285-8	1995	Furthermore, our results are in accordance with the observation that MEN 2A patients with Cys 634--&gt;Arg (germline) mutations have a higher risk of developing parathyroid disease than those with other mutations at codon 634.	Arginine	103-106	ret proto-oncogene	Homo sapiens	69-75
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Arginine	260-263	selectin P ligand	Homo sapiens	52-58
29541932-4	2018	Ubr1 is a RING-type E3 ubiquitin ligase of the Arg/N-end rule pathway, which causes the degradation of proteins bearing "destabilizing" N-terminal residues, such as neurodegeneration-associated protein fragment beta-amyloid.	Arginine	47-50	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	0-4
29541932-7	2018	Our results provide novel insights into the mechanism by which HSV-1-encoded miR-H1 functions in neurodegenerative pathogenesis through targeting Ubr1-mediated Arg/N-end rule degradation pathway.	Arginine	160-163	membrane associated ring-CH-type finger 8	Homo sapiens	77-80
29541932-7	2018	Our results provide novel insights into the mechanism by which HSV-1-encoded miR-H1 functions in neurodegenerative pathogenesis through targeting Ubr1-mediated Arg/N-end rule degradation pathway.	Arginine	160-163	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	146-150
29695495-2	2018	Previous studies have shown that mammalian Mre11 is methylated at multiple arginines in its C-terminal Glycine-Arginine-Rich motif (GAR) by protein arginine methyltransferase PRMT1.	Arginine	75-84	protein arginine methyltransferase 1	Homo sapiens	175-180
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Arginine	260-263	selectin P	Homo sapiens	70-80
29695495-2	2018	Previous studies have shown that mammalian Mre11 is methylated at multiple arginines in its C-terminal Glycine-Arginine-Rich motif (GAR) by protein arginine methyltransferase PRMT1.	Arginine	111-119	protein arginine methyltransferase 1	Homo sapiens	175-180
29695495-3	2018	Here, we found that the Drosophila Mre11 is methylated at arginines 559, 563, 565, and 569 in the GAR motif by DART1, the Drosophila homolog of PRMT1.	Arginine	58-67	protein arginine methyltransferase 1	Homo sapiens	144-149
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Arginine	260-263	selectin P ligand	Homo sapiens	156-162
7592904-5	1995	Consistent with a functional role of this region of PSGL-1 in binding P-selectin, an affinity-purified polyclonal antibody against residues Gln-1-Glu-15 of PSGL-1 strongly inhibited P-selectin binding to neutrophils, whereas an antibody against residues Asp-9-Arg-23 was noninhibitory.	Arginine	260-263	selectin P	Homo sapiens	182-192
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Arginine	192-195	sucrase-isomaltase	Homo sapiens	79-97
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Arginine	232-240	nth like DNA glycosylase 1	Homo sapiens	55-59
29610152-3	2018	We demonstrate that TRIM26 catalyzes ubiquitylation of NTH1 predominantly on lysine 67 present within the N terminus of the protein in vitro In addition, the stability of a ubiquitylation-deficient protein mutant of NTH1 (lysine to arginine) at this specific residue was significantly increased in comparison to the wild-type protein when transiently expressed in cultured cells.	Arginine	232-240	nth like DNA glycosylase 1	Homo sapiens	216-220
8521865-1	1995	This paper reports the phosphorylation of the intracellular N-terminal tail of sucrase-isomaltase by protein kinase A and shows that this phosphorylation is targeted to Ser6 within a sequence Arg/Lys/Lys-Phe-Ser, which is conserved in all sucrase-isomaltase sequences known so far.	Arginine	192-195	sucrase-isomaltase	Homo sapiens	239-257
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	8-11	histocompatibility 3b, Th stimulating	Mus musculus	69-72
29760946-6	2018	Asp-18, Arg-108, and Arg-667, respectively, in the pre-BIR, BIR1 and HD1 of NAIP2 are further identified, each of which is essential for efficient binding to the rod protein.	Arginine	21-24	histocompatibility 3b, Th stimulating	Mus musculus	69-72
7593456-2	1995	We have recently described a C to T transition in the HSD11B2 gene which results in an arginine to cysteine mutation (R337C) in the 11 beta HSD2 enzyme in a consanguineous family with three siblings suffering from Apparent Mineralocorticoid Excess (AME).	Arginine	87-95	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	54-61
7593456-2	1995	We have recently described a C to T transition in the HSD11B2 gene which results in an arginine to cysteine mutation (R337C) in the 11 beta HSD2 enzyme in a consanguineous family with three siblings suffering from Apparent Mineralocorticoid Excess (AME).	Arginine	87-95	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	132-144
29116606-8	2018	Sanger sequencing showed a homozygous missense mutation in SLC2A2 (exon 7, c.952G &gt; A), causing glycine to arginine substitution; both parents were heterozygous carriers.	Arginine	110-118	solute carrier family 2 member 2	Homo sapiens	59-65
29771430-0	2018	SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway.	Arginine	56-57	SUMO specific peptidase 3	Rattus norvegicus	0-5
7577911-5	1995	Therefore, site-specific mutagenesis has been used to probe the function of Arg-22 in pig kidney fructose-1,6-bisphosphatase.	Arginine	76-79	fructose-bisphosphatase 1	Sus scrofa	97-124
7575582-2	1995	We investigated whether lipopolysaccharide (LPS) treatment in vivo would alter tissue expression of mRNAs for argininosuccinate synthetase (AS) and argininosuccinate lyase (AL), the net action of which is to convert citrulline to arginine.	Arginine	230-238	argininosuccinate lyase	Rattus norvegicus	148-171
7559790-8	1995	AGT possessing the two amino acid substitutions responsible for its mistargeting in PH1 (i.e., Pro11--&gt;Leu and Gly170--&gt;Arg) was targeted mainly to the mitochondria.	Arginine	126-129	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	84-87
28856444-6	2018	Curcumin downregulated Cdx-2 and Hif-1alpha mRNA expression and upregulated HO-1 and SOD 2, and these effects were reversed by L-NNA and further restored by co-treatment of L-NNA with L-arginine.	Arginine	184-194	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
7633739-1	1995	Carboxypeptidase M (CPM) cleaves the C-terminal arginine and lysine of peptides; it is expressed in the lung, especially on the plasma membrane of alveolar type I cells.	Arginine	48-56	carboxypeptidase M	Homo sapiens	0-18
29854093-4	2018	L-Arg supplementation increased the activity of inducible nitric oxide synthase (iNOS), the rate of protein synthesis, and the phosphorylation of mTOR (Thr 2446) and p70S6K (Thr 389).	Arginine	0-5	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	166-172
7633739-1	1995	Carboxypeptidase M (CPM) cleaves the C-terminal arginine and lysine of peptides; it is expressed in the lung, especially on the plasma membrane of alveolar type I cells.	Arginine	48-56	carboxypeptidase M	Homo sapiens	20-23
28374859-1	2018	Arginase 1 (ARG1) and arginase 2 (ARG2) compete with nitric oxide synthases for the substrate l-arginine.	Arginine	94-104	arginase 2	Homo sapiens	22-32
28374859-1	2018	Arginase 1 (ARG1) and arginase 2 (ARG2) compete with nitric oxide synthases for the substrate l-arginine.	Arginine	94-104	arginase 2	Homo sapiens	34-38
7627718-6	1995	Chemical modification of LDL apoB lysines or arginines markedly reduced the ability of the lipoprotein to block the binding of 125I-LDL to LPL-containing matrix, suggesting that apoB positively charged amino acids are involved in the interaction.	Arginine	45-54	lipoprotein lipase	Homo sapiens	139-142
7619077-1	1995	The roles of Arg-104 and Arg-225 located in the 2-kinase domain of the bifunctional enzyme 6-phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase (FBPase-2) have been studied by site-directed mutagenesis.	Arginine	13-16	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	117-122
29383861-0	2018	Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy.	Arginine	63-71	pitrilysin metallopeptidase 1	Homo sapiens	33-62
7619077-1	1995	The roles of Arg-104 and Arg-225 located in the 2-kinase domain of the bifunctional enzyme 6-phosphofructo-2-kinase (PFK-2)/fructose-2,6-bisphosphatase (FBPase-2) have been studied by site-directed mutagenesis.	Arginine	25-28	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	117-122
29581108-10	2018	We identified arginine residues at positions 38, 42, and 68 in the endoplasmatic reticulum luminal loop of VKORC1L1 responsible for charge-stabilized warfarin binding, resulting in a binding pocket that is diametrically opposite to that of VKORC1.	Arginine	14-22	vitamin K epoxide reductase complex subunit 1 like 1	Homo sapiens	107-115
7790890-2	1995	Like other peptide processing enzymes, CPE is initially produced as a precursor ("proCPE") that undergoes posttranslational processing at a site containing five adjacent Arg residues near the N-terminus and at other sites near the C-terminus of proCPE.	Arginine	170-173	carboxypeptidase E	Homo sapiens	39-42
29212043-6	2018	Experiments with mutant proteins demonstrated that the conserved arginines in the PN-binding pocket are involved in the inhibition of UCP1 and UCP3 to different extents.	Arginine	65-74	uncoupling protein 3	Homo sapiens	143-147
29023917-0	2018	Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice.	Arginine	8-16	hepatic nuclear factor 4, alpha	Mus musculus	121-154
29023917-8	2018	We found that PRMT1 regulates Hnf4alpha expression directly through arginine methylation at the (Hnf4alpha) promoter.	Arginine	68-76	hepatic nuclear factor 4, alpha	Mus musculus	30-39
29023917-8	2018	We found that PRMT1 regulates Hnf4alpha expression directly through arginine methylation at the (Hnf4alpha) promoter.	Arginine	68-76	hepatic nuclear factor 4, alpha	Mus musculus	97-106
29289698-6	2018	TyrRS knockdown of PC12 cells with a small interfering RNA (siRNA) in the presence of 1.6 mM tyrosine, arginine, proline, or tryptophan significantly reduced the level of KTP, but not those of tyrosine-tyrosine, tyrosine-proline, or tyrosine-tryptophan.	Arginine	103-111	tyrosyl-tRNA synthetase 1	Rattus norvegicus	0-5
29658513-5	2018	The presence of heterozygous Arg-Gly and Gln-Glu gives a better response to drug therapy than the presence of Gly-Gly and Glu-Glu genotypes at codons 16 and 27.ConclusionPolymorphism of beta2AR at codons 16 and 27 correlates with asthma severity and response to treatment in asthmatic children.	Arginine	29-32	adrenoceptor beta 2	Homo sapiens	186-193
29459673-0	2018	Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.	Arginine	24-32	lysine demethylase 8	Homo sapiens	61-66
29459673-1	2018	We have reported that JMJD5 and JMJD7 (JMJD5/7) are responsible for the clipping of arginine methylated histone tails to generate "tailless nucleosomes", which could release the pausing RNA polymerase II (Pol II) into productive transcription elongation.	Arginine	84-92	lysine demethylase 8	Homo sapiens	22-27
29459673-7	2018	Furthermore, the complex structures of JMJD5 and arginine derivatives revealed a Tudor domain-like binding pocket to accommodate the methylated sidechain of arginine, but not lysine.	Arginine	157-165	lysine demethylase 8	Homo sapiens	39-44
29155213-2	2018	Human umbilical vein endothelial cells (HUVECs) from women with GDM show increased L-arginine transport via the human cationic amino acid transporter 1 (hCAT-1).	Arginine	83-93	solute carrier family 7 member 1	Homo sapiens	153-159
29556330-10	2018	Whereas, we found that patients with XRCC1 399Arg/Gln and Gln/Gln genotypes had a lower risk of RP compares with those carrying Arg/Arg genotype (adjusted HR 0.653; 95% CI 0.342-1.245), but with no statistical significance observed (adjusted P = 0.195).	Arginine	46-49	X-ray repair cross complementing 1	Homo sapiens	37-42
29227283-4	2018	Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI.	Arginine	107-115	SHANK associated RH domain interactor	Homo sapiens	89-96
29128679-7	2018	In this case, we identified a de novo mutation (c.4423G &gt; A; glycine [Gly]1475 arginine [Arg]) classified as heterozygous missense located in the inactivation gate section of the SCN8A (voltage-gated sodium-channel type VIII alpha subunit) gene.	Arginine	82-90	sodium voltage-gated channel alpha subunit 8	Homo sapiens	182-241
29128679-7	2018	In this case, we identified a de novo mutation (c.4423G &gt; A; glycine [Gly]1475 arginine [Arg]) classified as heterozygous missense located in the inactivation gate section of the SCN8A (voltage-gated sodium-channel type VIII alpha subunit) gene.	Arginine	92-95	sodium voltage-gated channel alpha subunit 8	Homo sapiens	182-241
28212872-6	2018	RESULTS: The percentages of the gp78 gene polymorphisms of Arg/Arg, Arg/Gly and Gly/Gly at the 145 locus of the study subjects in the observation group were 12.3%, 43.2% and 44.5%, respectively, while those in the control group were 74.3%, 11.2% and 14.5%, respectively, and there were significant differences between both groups.	Arginine	59-62	autocrine motility factor receptor	Homo sapiens	32-36
28212872-6	2018	RESULTS: The percentages of the gp78 gene polymorphisms of Arg/Arg, Arg/Gly and Gly/Gly at the 145 locus of the study subjects in the observation group were 12.3%, 43.2% and 44.5%, respectively, while those in the control group were 74.3%, 11.2% and 14.5%, respectively, and there were significant differences between both groups.	Arginine	63-66	autocrine motility factor receptor	Homo sapiens	32-36
28212872-6	2018	RESULTS: The percentages of the gp78 gene polymorphisms of Arg/Arg, Arg/Gly and Gly/Gly at the 145 locus of the study subjects in the observation group were 12.3%, 43.2% and 44.5%, respectively, while those in the control group were 74.3%, 11.2% and 14.5%, respectively, and there were significant differences between both groups.	Arginine	63-66	autocrine motility factor receptor	Homo sapiens	32-36
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	39-42	carboxypeptidase E	Mus musculus	8-11
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	39-42	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	39-42	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	320-323	carboxypeptidase E	Mus musculus	8-11
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	320-323	carboxypeptidase E	Mus musculus	109-112
29476513-4	2018	Because CPE removes C-terminal Lys and Arg residues from peptide-processing intermediates, organisms lacking CPE show a large decrease in the levels of the mature forms of most neuropeptides and peptide hormones, and a very large increase in the levels of the processing intermediates that contain C-terminal Lys and/or Arg (i.e., the CPE substrates).	Arginine	320-323	carboxypeptidase E	Mus musculus	109-112
28860090-5	2018	The newly formed C3a-like peptide lacked the C-terminal arginine residue needed for C3a-receptor binding and activation.	Arginine	56-64	complement C3	Homo sapiens	17-20
29259090-4	2017	Importantly, variants of this gene have been associated with age at first acquisition of Pseudomonas aeruginosa In this study, we aimed to determine the function of SLC6A14 in airway epithelia and how it might affect colonization by P. aeruginosa We show that SLC6A14 is expressed in respiratory epithelial cells and transports l-arginine out of the airway surface liquid (ASL).	Arginine	328-338	solute carrier family 6 member 14	Homo sapiens	165-172
29259090-5	2017	Exposure of airway epithelia to flagellin from P. aeruginosa led to upregulation of SLC6A14 expression and increased SLC6A14-dependent uptake of l-arginine from the ASL.	Arginine	145-155	solute carrier family 6 member 14	Homo sapiens	117-124
29259090-7	2017	In a coculture model, we found that inhibition of SLC6A14-dependent l-arginine transport enhanced P. aeruginosa attachment.	Arginine	68-78	solute carrier family 6 member 14	Homo sapiens	50-57
29259090-9	2017	Together, these findings suggest that SLC6A14 activity plays a role in the modification of the initial stages of airway infection by altering the level of l-arginine in the ASL, which in turn affects the attachment of P. aeruginosaIMPORTANCE CF patients with shared CFTR gene mutations show significant variability in their clinical presentation of infectious lung disease.	Arginine	155-165	solute carrier family 6 member 14	Homo sapiens	38-45
29259090-12	2017	In this study, we interrogated the biological role of one of these modifiers, SLC6A14, and showed that it contributes to host defense by depleting extracellular arginine (an attachment-promoting metabolite for P. aeruginosa) from the airway surface liquid.	Arginine	161-169	solute carrier family 6 member 14	Homo sapiens	78-85
29121239-1	2017	argC encodes N-acetyl-gamma-glutamyl phosphate reductase, the enzyme that catalyzes the high-energy-consuming third step in the arginine synthesis pathway.	Arginine	128-136	N-acetyl-gamma-glutamyl-phosphate reductase	Sinorhizobium meliloti 1021	0-4
29121239-10	2017	Overproduction of ArgC protein for the synthesis of arginine induced physiological and symbiotic effects.	Arginine	52-60	N-acetyl-gamma-glutamyl-phosphate reductase	Sinorhizobium meliloti 1021	18-22
28636189-2	2017	In particular, PRMT1 is responsible for over 85% of the arginine methylation in mammalian cells.	Arginine	56-64	protein arginine methyltransferase 1	Homo sapiens	15-20
29094484-6	2017	These BR cells also showed a metabolic shift from glucose to arginine dependence, which was supported by decreased expressions of GLUT1 (glucose transporter) and hexokinase II (HKII) coupled with less glucose uptake but high levels of arginine transporter CAT-2 expression.	Arginine	61-69	solute carrier family 2 member 1	Homo sapiens	130-135
29118143-0	2017	Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.	Arginine	21-29	piwi like RNA-mediated gene silencing 1	Homo sapiens	69-75
29118143-5	2017	Unlike most other Tudor domains, the extended Tudor domain of mammalian Tudor domain-containing protein 2 (TDRD2) preferentially recognizes an unmethylated arginine-rich sequence from PIWI-like protein 1 (PIWIL1).	Arginine	156-164	piwi like RNA-mediated gene silencing 1	Homo sapiens	184-203
29118143-5	2017	Unlike most other Tudor domains, the extended Tudor domain of mammalian Tudor domain-containing protein 2 (TDRD2) preferentially recognizes an unmethylated arginine-rich sequence from PIWI-like protein 1 (PIWIL1).	Arginine	156-164	piwi like RNA-mediated gene silencing 1	Homo sapiens	205-211
29163459-6	2017	However, recombinant strains carrying the can1 mutation failed to produce urea, suggesting that the genetic modification successfully impaired the arginine metabolism.	Arginine	147-155	arginine permease CAN1	Saccharomyces cerevisiae S288C	42-46
29061864-1	2017	The predominating beta-adrenergic receptor subtype expressed on human alveolar tissue is the beta2AR The homozygous arginine (Arg16Arg) single-nucleotide polymorphism (SNP) at codon 16 of the beta2AR gene has been associated with abnormal beta2AR function accompanied by decreased resting alveolar-capillary membrane gas-transfer in certain healthy adults.	Arginine	116-124	adrenoceptor beta 2	Homo sapiens	93-100
29061864-1	2017	The predominating beta-adrenergic receptor subtype expressed on human alveolar tissue is the beta2AR The homozygous arginine (Arg16Arg) single-nucleotide polymorphism (SNP) at codon 16 of the beta2AR gene has been associated with abnormal beta2AR function accompanied by decreased resting alveolar-capillary membrane gas-transfer in certain healthy adults.	Arginine	116-124	adrenoceptor beta 2	Homo sapiens	192-199
29061864-1	2017	The predominating beta-adrenergic receptor subtype expressed on human alveolar tissue is the beta2AR The homozygous arginine (Arg16Arg) single-nucleotide polymorphism (SNP) at codon 16 of the beta2AR gene has been associated with abnormal beta2AR function accompanied by decreased resting alveolar-capillary membrane gas-transfer in certain healthy adults.	Arginine	116-124	adrenoceptor beta 2	Homo sapiens	192-199
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	105-115	G protein-coupled receptor 161	Homo sapiens	324-327
29053970-2	2017	Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters.	Arginine	24-32	solute carrier family 38 member 9	Homo sapiens	42-49
29053970-3	2017	Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis.	Arginine	37-45	solute carrier family 38 member 9	Homo sapiens	23-30
28813605-2	2017	For both ASP and AGRP, the hypothesized Arg-Phe-Phe pharmacophores are on exposed beta-hairpin loops.	Arginine	40-43	agouti signaling protein	Homo sapiens	9-12
28813605-2	2017	For both ASP and AGRP, the hypothesized Arg-Phe-Phe pharmacophores are on exposed beta-hairpin loops.	Arginine	40-43	agouti related neuropeptide	Homo sapiens	17-21
29020930-6	2017	RESULTS: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95%CI, 1.30-10.72) compared with Gln/Gln homozygosity.	Arginine	13-16	X-ray repair cross complementing 1	Homo sapiens	52-57
29020930-6	2017	RESULTS: The Arg/Arg homozygote polymorphism of the XRCC1 gene was associated with an increased risk of stomach cancer in the Thai population (OR adj, 3.7; 95%CI, 1.30-10.72) compared with Gln/Gln homozygosity.	Arginine	17-20	X-ray repair cross complementing 1	Homo sapiens	52-57
29020930-7	2017	The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype.	Arginine	168-171	X-ray repair cross complementing 1	Homo sapiens	18-23
29020930-7	2017	The effect of the XRCC1gene on the risk of stomach cancer was modified by both a high intake of vegetable oils and salt (p = 0.036 and p = 0.014), particularly for the Arg/Arg homozygous genotype.	Arginine	172-175	X-ray repair cross complementing 1	Homo sapiens	18-23
29020930-9	2017	CONCLUSIONS: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.	Arginine	69-72	X-ray repair cross complementing 1	Homo sapiens	31-36
29020930-9	2017	CONCLUSIONS: The effect of the XRCC1 gene homozygosity, particularly Arg/Arg, on the risk for stomach cancer was elevated by a high intake of vegetable oils and salt.	Arginine	73-76	X-ray repair cross complementing 1	Homo sapiens	31-36
28985504-5	2017	Facilitated by BMAL1 (brain and muscle Arnt-like protein), CLOCK directly acetylates K165 and K176 of argininosuccinate synthase (ASS1) to inactivate ASS1, which catalyzes the rate-limiting step of arginine biosynthesis.	Arginine	198-206	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	15-20
29053416-1	2017	Integrin alphavbeta3 is a molecular marker for the estimation of tumor angiogenesis and is an imaging target for radiolabeled Arg-Gly-Asp (RGD) peptides.	Arginine	126-129	integrin subunit alpha V	Homo sapiens	0-20
28432839-2	2017	ASP resembles Saccharomyces cerevisiae Kex2, a member of the subtilisin family, and preferentially cleaves peptide bonds at the C-terminal side of paired basic amino acid residues; also accepting unpaired arginine at the P1 site.	Arginine	205-213	kexin KEX2	Saccharomyces cerevisiae S288C	39-43
28847961-0	2017	Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.	Arginine	12-20	lysine demethylase 8	Homo sapiens	49-54
28847961-2	2017	Here, we report that two orphan Jumonji C domain (JmjC)-containing proteins, JMJD5 and JMJD7, have divalent cation-dependent protease activities that preferentially cleave the tails of histones 2, 3, or 4 containing methylated arginines.	Arginine	227-236	lysine demethylase 8	Homo sapiens	77-82
28847961-4	2017	JMJD5-deficient fibroblasts exhibit dramatically increased levels of methylated arginines and histones.	Arginine	80-89	lysine demethylase 8	Homo sapiens	0-5
28847961-6	2017	The protease activities of JMJD5 and JMJD7 represent a mechanism for removal of histone tails bearing methylated arginine residues and define a potential mechanism of transcription regulation.	Arginine	113-121	lysine demethylase 8	Homo sapiens	27-32
28870898-6	2017	Our studies indicated that ATA strongly inactivates and binds in the PTP1B and SHP2 active site, interacting with arginine residue essential for enzyme activity.	Arginine	114-122	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	69-74
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	glutathione peroxidase 1	Homo sapiens	63-67
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	gamma-glutamylcyclotransferase	Homo sapiens	80-84
28962167-8	2017	PEPCK mRNA and G-6-Pase mRNA expression levels in the offspring of the IUGR group were higher compared with those in the CON group but were downregulated following L-Arg supplementation.	Arginine	164-169	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	0-5
28594599-5	2017	We found that IL-4Ralpha haplotypes for Val75Ile, Ser503Pro, and Arg576Gln were associated with measles IgG in Mozambican children (p = 0.016 and p = 0.032 for Val.Pro.Arg and Val.Ser.Arg, respectively), but not Australian children.	Arginine	65-68	interleukin 4 receptor	Homo sapiens	14-24
28594599-5	2017	We found that IL-4Ralpha haplotypes for Val75Ile, Ser503Pro, and Arg576Gln were associated with measles IgG in Mozambican children (p = 0.016 and p = 0.032 for Val.Pro.Arg and Val.Ser.Arg, respectively), but not Australian children.	Arginine	168-171	interleukin 4 receptor	Homo sapiens	14-24
28802308-7	2017	Laser microdissection of salivary gland Congo-red deposits and tandem mass spectrometry-based proteomic analysis identified the mutated transthyretin peptide containing the arginine residue at position 87 of the mature protein.	Arginine	173-181	transthyretin	Homo sapiens	136-149
7751635-6	1995	By a single Arg to Asn mutation, an N-linked glycosylation site similar to that of LL-2 was introduced in the FR-1 segment of a nonglycosylated, humanized anti-carcinoembryonic Ag (CEA) Ab, MN-14 (hMN-14).	Arginine	12-15	peroxiredoxin 2, pseudogene 1	Mus musculus	83-87
7538758-7	1995	These observations are taken as strong evidence that the DHFR module contains the L-arginine binding site and, presumably, the BH4 binding site by analogy to its homology with DHFR, but that tight binding of BH4 requires amino acids 220-577.	Arginine	82-92	Dihydrofolate reductase	Escherichia coli	57-61
28368422-6	2017	Importantly, Abl/Arg activation downstream of BRAFV600E has functional and biological significance, driving proliferation, invasion, as well as switch in epithelial-mesenchymal-transition transcription factor expression, which is known to be critical for melanoma cells to shift between differentiated and invasive states.	Arginine	17-20	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	13-16
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	91-94	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-90
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	91-94	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	220-223
28368422-7	2017	Finally, we describe findings of high translational significance by demonstrating that Abl/Arg cooperate with PI3K/Akt/PTEN, a parallel pathway that is associated with intrinsic resistance to BRAFi and immunotherapy, as Abl/Arg and Akt inhibitors cooperate to prevent viability, cell cycle progression and in vivo growth of melanomas harboring mutant BRAF/PTEN.	Arginine	224-227	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-90
7538758-7	1995	These observations are taken as strong evidence that the DHFR module contains the L-arginine binding site and, presumably, the BH4 binding site by analogy to its homology with DHFR, but that tight binding of BH4 requires amino acids 220-577.	Arginine	82-92	Dihydrofolate reductase	Escherichia coli	176-180
28436014-3	2017	We assessed the extent to which the pharmacokinetic characteristics are a function of the staple for a peptide inhibiting the interaction of p53 with the human double minute 2 (Hdm2) protein and differ from those of the standard cationic cell-penetrating peptide nona-arginine.	Arginine	268-276	MDM2 proto-oncogene	Homo sapiens	177-181
7744752-2	1995	A key reagent in these experiments is a PAI-1 mutant, having its P1 reactive center residue arginine replaced by methionine (PAI-1 R346M).	Arginine	92-100	serpin family E member 1	Homo sapiens	40-45
28644004-0	2017	Intricate Effects of alpha-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.	Arginine	61-69	H4 clustered histone 9	Homo sapiens	108-118
28644004-5	2017	In this study, we investigated how naturally occurring N-terminal acetylation and PTMs of histone H4 lysine-5 (H4K5) affect arginine-3 methylation catalyzed by both type I and type II PRMTs at the biochemical level.	Arginine	124-132	H4 clustered histone 9	Homo sapiens	90-100
28644004-6	2017	Our studies found that acylations of H4K5 resulted in decreased levels of arginine methylation by PRMT1, PRMT3, and PRMT8.	Arginine	74-82	protein arginine methyltransferase 1	Homo sapiens	98-103
28954469-2	2017	Our current study was aimed to explore the effect of L-arginine on skin fibroblast (L929) signaling pathways involved in cell proliferation (Akt-pAkt kinase, Erk/pErk1/2 kinase, JNK/pJNK kinase and pStat-1), apoptosis (Bcl2 and Bax) and immune defense (NF-kappaB and CD26).	Arginine	53-63	BCL2-associated X protein	Mus musculus	228-231
7752246-6	1995	However, for the mSos1 peptide a salt bridge can be formed between the arginine of the proline-rich peptide and the protein at Asp15, Glu16 and Glu31 only in one direction; this orientation seems to be strongly preferred.	Arginine	71-79	SOS Ras/Rac guanine nucleotide exchange factor 1	Mus musculus	17-22
28954469-5	2017	The exposure of skin fibroblasts to L-arginine increased anti-apoptotic Bcl2/Bax stoichiometry ratio (p&lt;0.05), obtained by calculation of their individual quantities.	Arginine	36-46	BCL2-associated X protein	Mus musculus	77-80
7741698-1	1995	Based upon the observed cleavage of various peptidyl substrates by the recombinant prohormone convertases PC1 and furin, an intramolecularly quenched fluorogenic peptidyl substrate, (o-aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg-Ser-Ala-Leu-Arg-Asp-(3-nitro)Ty r-Ala, was synthesized.	Arginine	207-210	proprotein convertase subtilisin/kexin type 1	Homo sapiens	106-109
28516783-6	2017	Stabilizing ligands favor an extended N-terminus, which sterically positions two arginine residues for optimal Coulombic interaction with a pair of carboxylate side chains from GCK.	Arginine	81-89	glucokinase	Homo sapiens	177-180
7741698-4	1995	Both recombinant human PC1 and human furin recognize and cleave specifically this substrate at the expected Arg-Ser site in a sensitive manner.	Arginine	108-111	proprotein convertase subtilisin/kexin type 1	Homo sapiens	23-26
7633596-4	1995	N-Terminal sequencing revealed IGF II and an IGF II variant in which Ser29 was replaced by the tetrapeptide Arg-Leu-Pro-Gly.	Arginine	108-111	insulin like growth factor 2	Homo sapiens	45-51
28472517-4	2017	Npl3 is related to both the metazoan serine-arginine-rich and the heterogeneous nuclear ribonucleo-proteins.	Arginine	44-52	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	0-4
7718575-8	1995	The GCD cleaved the fluorogenic peptides Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 and Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 with catalytic efficiency close to full length human gelatinase A.	Arginine	69-72	guanylate cyclase 2E, pseudogene	Homo sapiens	4-7
28559311-5	2017	By introducing point mutations into TMEM16F, we found that a lysine in the fourth transmembrane segment of the SCRD as well as an arginine in the third and a glutamic acid in the sixth transmembrane segment were important for exposing phosphatidylserine from the inner to the outer leaflet.	Arginine	130-138	anoctamin 6	Homo sapiens	36-43
7698503-9	1995	Arginine, theophylline, and propionic acid increased insulin secretion from freshly isolated islets at 3.3 and 14 mmol/l glucose, but not at 25 mmol/l glucose.	Arginine	0-8	insulin	Bos taurus	53-60
28701241-8	2017	Supplementation with Arg significantly decreased crypt depth (P&lt;0 05), suppressed CAT-1 mRNA expression induced by diquat (P&lt;0 05), increased ARGII and endothelial nitric oxide synthase mRNA levels (P&lt;0 05), and effectively relieved the TNF- alpha mRNA expression induced by diquat in the jejunum (P&lt;0 05).	Arginine	21-24	solute carrier family 7 member 1	Homo sapiens	85-90
28158808-0	2017	Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.	Arginine	78-86	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	25-31
7633398-1	1995	We have studied two different missense mutations at arginine-830 in exon 7 of the human androgen receptor (hAR) gene that cause complete androgen insensitivity (CAIS) in three families.	Arginine	52-60	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	107-110
7706490-4	1995	The second mutation, located in exon 46, substituted a cysteine proximal to the NC1 domain of COL4A5 for an arginine.	Arginine	108-116	collagen type IV alpha 5 chain	Homo sapiens	94-100
28315470-8	2017	At the individual gene level, we identified many differentially expressed genes of the citrulline/arginine metabolism pathway such as ARG1, ARG2, GLS, OAT and OTC in response to EGF and INDO.	Arginine	98-106	arginase 2	Homo sapiens	140-144
7891704-5	1995	First, an important arginine found in the Oct-1 POUS domain tolerates substitutions of its base contacts within the octamer site.	Arginine	20-28	POU class 2 homeobox 1	Homo sapiens	42-47
28536481-3	2017	By screening the serine/arginine-rich splicing factors (SRSFs), we report that the transcript and protein levels of SRSF5 were increased in mammalian cells cultured at 32  C. Expression of SRSF5 as well as CIRP and RBM3 were also induced by DNA damage, hypoxia, cycloheximide and hypotonicity.	Arginine	24-32	serine and arginine rich splicing factor 5	Homo sapiens	116-121
7890732-8	1995	Arg-175 also appears to function as a phosphorylation-sensitive trigger since charge neutralization by mutagenesis enables arrestin-R175N to bind to light-activated rhodopsin as well as wild-type arrestin binds to phosphorylated light-activated rhodopsin.	Arginine	0-3	rhodopsin	Bos taurus	165-174
28296653-10	2017	CONCLUSION: These results show that the modulation of hypothalamic NO signaling can affect the rat"s running performance during a treadmill exercise and that enhanced NO signaling by induction of nNOS in PVN and DMH plays a role in improving exercise capacity after central administration of L-Arg.	Arginine	292-297	nitric oxide synthase 1	Rattus norvegicus	196-200
7890732-8	1995	Arg-175 also appears to function as a phosphorylation-sensitive trigger since charge neutralization by mutagenesis enables arrestin-R175N to bind to light-activated rhodopsin as well as wild-type arrestin binds to phosphorylated light-activated rhodopsin.	Arginine	0-3	rhodopsin	Bos taurus	245-254
7538426-3	1995	Although ineffective by itself, LPL in combination with IFN-gamma increased L-arginine-dependent NO production in a dose-dependent manner.	Arginine	76-86	lipoprotein lipase	Homo sapiens	32-35
28254587-3	2017	KLK6 has a very restricted specificity for arginine (R) and hydrolyses myelin basic protein, protein activator receptors and human ionotropic glutamate receptor subunits.	Arginine	43-51	kallikrein related peptidase 6	Homo sapiens	0-4
7538426-9	1995	These data provide evidence for a link between LPL and arginine metabolism in macrophages and further stress the role of LPL in the regulation of macrophage activation.	Arginine	55-63	lipoprotein lipase	Homo sapiens	47-50
7607422-3	1995	Results obtained using Southern blotting and plasmid rescue techniques demonstrated that plasmid pARG7.8, containing only the arg7 gene, is able both to integrate into the chromosome and to be maintained, in some cases, in the autonomous state in Arg+ transformants of alga.	Arginine	247-250	uncharacterized protein	Chlamydomonas reinhardtii	126-130
29297546-13	2017	In conclusion, the polymorphism rs17576 (glutamine for arginine substitution) in MMP9 was a protective factor for AOB.	Arginine	55-63	matrix metallopeptidase 9	Homo sapiens	81-85
7622614-0	1995	Cysteine-to-arginine point mutation in a "hybrid" eight-cysteine domain of FBN1: consequences for fibrillin aggregation and microfibril assembly.	Arginine	12-20	fibrillin 1	Homo sapiens	75-79
28089735-9	2017	CONCLUSION: Our results suggest that, in the presence of high-glucose levels, increased l-arginine uptake due to simvastatin treatment was associated with increased CAT-1 and eNOS mRNA levels, leading to higher NO production in TR-iBRB cells.	Arginine	88-98	nitric oxide synthase 3	Rattus norvegicus	175-179
7735837-2	1995	The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk.	Arginine	39-47	cyclin dependent kinase 20	Homo sapiens	132-137
28004516-1	2017	Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery.	Arginine	25-33	integrin subunit alpha V	Homo sapiens	94-115
28004516-1	2017	Peptides with an exposed arginine-glycine-aspartate (Arg-Gly-Asp, RGD) sequence targeting the integrin alphaV beta3 play an important role in targeted anticancer drug delivery.	Arginine	53-56	integrin subunit alpha V	Homo sapiens	94-115
28250123-4	2017	To elucidate the structural requirements within the NS1 protein for PKR inhibition, we generated a set of mutant viruses, identifying highly conserved arginine residues 35 and 46 within the NS1 N terminus as being most critical not only for binding to and blocking activation of PKR but also for efficient virus propagation.	Arginine	151-159	influenza virus NS1A binding protein	Homo sapiens	52-55
28250123-4	2017	To elucidate the structural requirements within the NS1 protein for PKR inhibition, we generated a set of mutant viruses, identifying highly conserved arginine residues 35 and 46 within the NS1 N terminus as being most critical not only for binding to and blocking activation of PKR but also for efficient virus propagation.	Arginine	151-159	influenza virus NS1A binding protein	Homo sapiens	190-193
28250123-10	2017	Using mutational analysis, we identified arginine residues 35 and 46 within the N-terminal NS1 domain as highly critical for binding to and functional silencing of PKR.	Arginine	41-49	influenza virus NS1A binding protein	Homo sapiens	91-94
7735837-6	1995	In contrast, the co-crystal structure of c-Crk SH3-N and a peptide containing an arginine at the equivalent position (determined at 1.9 A resolution) reveals non-optimal geometry for the arginine and increased disorder.	Arginine	81-89	cyclin dependent kinase 20	Homo sapiens	41-46
7735837-6	1995	In contrast, the co-crystal structure of c-Crk SH3-N and a peptide containing an arginine at the equivalent position (determined at 1.9 A resolution) reveals non-optimal geometry for the arginine and increased disorder.	Arginine	187-195	cyclin dependent kinase 20	Homo sapiens	41-46
7537683-4	1995	In contrast, treatment with precursors of NO in the arginine-to-NO pathway, such as sodium nitroprusside, S-nitro-N-acetylpenicillamine and N-morpholino sydnonimine exacerbated the 15-min hypoxia/hypoglycemia-induced decrease in the CA1 presynaptic potential.	Arginine	52-60	carbonic anhydrase 1	Rattus norvegicus	233-236
28330868-2	2017	We recently reported defects in protein arginine methyltransferase 1 (PRMT1) activity and arginine methylation in the livers of cirrhosis patients with a history of recurrent infections.	Arginine	40-48	protein arginine methyltransferase 1	Homo sapiens	70-75
27875754-0	2017	The impact of diet and arginine supplementation on pancreatic mass, digestive enzyme activity, and insulin-containing cell cluster morphology during the estrous cycle in sheep.	Arginine	23-31	LOC105613195	Ovis aries	99-106
28188227-9	2017	The presence of Erap1 increased the frequency of C-terminal Lys and Arg, of Glu and Asp at intermediate residues, and of N-terminal Gly.	Arginine	68-71	endoplasmic reticulum aminopeptidase 1	Rattus norvegicus	16-21
28334039-8	2017	System y+ CAT1 siRNA decreased CAT1 expression, L-Arg transport activity and attenuated the inhibitory effects of L-Arg on NF- kappaB activity.	Arginine	114-119	solute carrier family 7 member 1	Homo sapiens	10-14
28285824-6	2017	We discovered that Reelin regulates several phosphorylation sites within the positively charged serine/arginine-rich region that constitute consensus GSK3beta phosphorylation motifs of CLASP2.	Arginine	103-111	reelin	Homo sapiens	19-25
27932057-3	2017	An arginine-rich, fatty acid coupled, cyclic peptide (CycK(Myr)R4E) with high proteolytic stability and prolonged circulation was developed for the scavenging of MG.	Arginine	3-11	cyclin K	Mus musculus	54-58
27994012-1	2017	Protein arginine methyltransferase 1 (PRMT-1) catalyzes asymmetric arginine dimethylation on cellular proteins and modulates various aspects of biological processes, such as signal transduction, DNA repair, and transcriptional regulation.	Arginine	8-16	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	38-44
27994012-4	2017	Subcellular fractionation followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis showed that PRMT-1 is almost entirely responsible for asymmetric arginine dimethylation on mitochondrial proteins.	Arginine	170-178	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	117-123
27994012-5	2017	Importantly, isolated mitochondria from prmt-1 mutants represent compromised ATP synthesis in vitro, and whole-worm respiration in prmt-1 mutants is decreased in vivo Transgenic rescue experiments demonstrate that PRMT-1-dependent asymmetric arginine dimethylation is required to prevent mitochondrial reactive oxygen species (ROS) production, which consequently causes the activation of the mitochondrial unfolded-protein response.	Arginine	242-250	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	40-46
27994012-5	2017	Importantly, isolated mitochondria from prmt-1 mutants represent compromised ATP synthesis in vitro, and whole-worm respiration in prmt-1 mutants is decreased in vivo Transgenic rescue experiments demonstrate that PRMT-1-dependent asymmetric arginine dimethylation is required to prevent mitochondrial reactive oxygen species (ROS) production, which consequently causes the activation of the mitochondrial unfolded-protein response.	Arginine	242-250	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	131-137
27994012-5	2017	Importantly, isolated mitochondria from prmt-1 mutants represent compromised ATP synthesis in vitro, and whole-worm respiration in prmt-1 mutants is decreased in vivo Transgenic rescue experiments demonstrate that PRMT-1-dependent asymmetric arginine dimethylation is required to prevent mitochondrial reactive oxygen species (ROS) production, which consequently causes the activation of the mitochondrial unfolded-protein response.	Arginine	242-250	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	214-220
27977123-9	2017	This information is particularly important for those using yeast display technology, as library members with Ali/Leu-X-Lys/Arg-Arg patterns are likely being removed from screens via Kex2 cleavage without the researcher"s knowledge.	Arginine	123-126	kexin KEX2	Saccharomyces cerevisiae S288C	182-186
27977123-9	2017	This information is particularly important for those using yeast display technology, as library members with Ali/Leu-X-Lys/Arg-Arg patterns are likely being removed from screens via Kex2 cleavage without the researcher"s knowledge.	Arginine	127-130	kexin KEX2	Saccharomyces cerevisiae S288C	182-186
27915016-0	2017	Injectable supramolecular hydrogel formed from alpha-cyclodextrin and PEGylated arginine-functionalized poly(l-lysine) dendron for sustained MMP-9 shRNA plasmid delivery.	Arginine	80-88	matrix metallopeptidase 9	Homo sapiens	141-146
27706899-9	2017	The GA loaded in FA-Arg-PEUU NP carriers at as low as 0.6 microg/mL GA concentration led to lower MMP-2 and MMP-9 activity of cancer cells compared to free GA, suggesting that GA-loaded Arg-PEUU NPs may have greater potential to reduce cancer cell invasion and metastasis than free GA.   2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 475-490, 2017.	Arginine	20-23	matrix metallopeptidase 9	Homo sapiens	108-113
27706899-9	2017	The GA loaded in FA-Arg-PEUU NP carriers at as low as 0.6 microg/mL GA concentration led to lower MMP-2 and MMP-9 activity of cancer cells compared to free GA, suggesting that GA-loaded Arg-PEUU NPs may have greater potential to reduce cancer cell invasion and metastasis than free GA.   2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 475-490, 2017.	Arginine	186-189	matrix metallopeptidase 9	Homo sapiens	108-113
27895153-6	2017	Attenuation of Ku80 ubiquitylation by replacement of ubiquitylation site lysines with arginine residues delayed Ku70/80 release from chromatin after DSB induction by genotoxic insults.	Arginine	86-94	X-ray repair cross complementing 6	Homo sapiens	112-116
27936311-4	2017	By using hollow mesoporous organosilica nanoparticle (HMON) as a biocompatible/biodegradable nanocarrier for the co-delivery of GOx and l-Arg, a novel glucose-responsive nanomedicine (l-Arg-HMON-GOx) has been for the first time constructed for synergistic cancer starving-like/gas therapy without the need of external excitation, which yields a remarkable H2 O2 -NO cooperative anticancer effect with minimal adverse effect.	Arginine	136-141	hydroxyacid oxidase 1	Homo sapiens	195-198
28013347-9	2017	Finally, we demonstrated the direct interaction between Ang II and MD2 protein via hydrogen bonds on Arg-90, Glu-92, and Asp-100.	Arginine	101-104	lymphocyte antigen 96	Rattus norvegicus	67-70
28854440-7	2017	The expression levels of Nrf2, HO-1, and HSP70 were strongly increased, and the expression of NF-kappaB and production of ROS were significantly decreased in the L-arginine group compared to that of the I/R group.	Arginine	162-172	heme oxygenase 1	Rattus norvegicus	31-35
28854440-9	2017	CONCLUSION: These findings suggested that L-arginine/NO reduces renal dysfunction associated with I/R of the kidney and may act as a trigger to regulate the NF-kappaB, HSP70 and Nrf2/HO-1 signaling cascades.	Arginine	42-52	heme oxygenase 1	Rattus norvegicus	183-187
28066558-0	2016	Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.	Arginine	29-37	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	64-71
28066558-2	2016	CASTOR1 has been identified as the cytosolic arginine sensor for the mTORC1 pathway, but the molecular mechanism of how it senses arginine is elusive.	Arginine	45-53	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	0-7
28066558-2	2016	CASTOR1 has been identified as the cytosolic arginine sensor for the mTORC1 pathway, but the molecular mechanism of how it senses arginine is elusive.	Arginine	130-138	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	0-7
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	76-84	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	52-59
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	76-84	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	178-185
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	212-220	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	52-59
28066558-3	2016	Here, by determining the crystal structure of human CASTOR1 in complex with arginine, we found that an exquisitely tailored pocket, carved between the NTD and the CTD domains of CASTOR1, is employed to recognize arginine.	Arginine	212-220	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	178-185
28066558-5	2016	By comparison with structurally similar aspartate kinases, a surface patch of CASTOR1-NTD on the opposite side of the arginine-binding site was identified to mediate direct physical interaction with its downstream effector GATOR2, via GATOR2 subunit Mios.	Arginine	118-126	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	78-85
28066558-9	2016	Our study thus provides a thorough analysis on how CASTOR1 recognizes arginine, and describes a possible mechanism of how arginine binding induces the inter-domain movement of CASTOR1 to affect its association with GATOR2.	Arginine	70-78	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	51-58
28066558-9	2016	Our study thus provides a thorough analysis on how CASTOR1 recognizes arginine, and describes a possible mechanism of how arginine binding induces the inter-domain movement of CASTOR1 to affect its association with GATOR2.	Arginine	70-78	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	176-183
28066558-9	2016	Our study thus provides a thorough analysis on how CASTOR1 recognizes arginine, and describes a possible mechanism of how arginine binding induces the inter-domain movement of CASTOR1 to affect its association with GATOR2.	Arginine	122-130	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	51-58
28066558-9	2016	Our study thus provides a thorough analysis on how CASTOR1 recognizes arginine, and describes a possible mechanism of how arginine binding induces the inter-domain movement of CASTOR1 to affect its association with GATOR2.	Arginine	122-130	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	176-183
28002734-6	2016	Domain-substitution and mutagenesis experiments further demonstrate that arginines surrounding the phosphorylated SF1 loop are required for cooperative 3" splice site recognition by the SF1-U2AF65 complex (where cooperativity is defined as a nonadditive increase in RNA binding by the protein complex relative to the individual proteins).	Arginine	73-82	splicing factor 1	Homo sapiens	114-117
28002734-6	2016	Domain-substitution and mutagenesis experiments further demonstrate that arginines surrounding the phosphorylated SF1 loop are required for cooperative 3" splice site recognition by the SF1-U2AF65 complex (where cooperativity is defined as a nonadditive increase in RNA binding by the protein complex relative to the individual proteins).	Arginine	73-82	splicing factor 1	Homo sapiens	186-189
28002589-5	2016	Univariate and multivariate logistic regression analyses revealed that the Arg/Arg genotype of COL9A2 Gln326Arg was associated with increased risk of intervertebral disc disease in comparison to the Gln/Gln genotype [crude odds ratio (OR) = 2.25, 95% confidence interval (CI) = 1.12-4.62; adjusted OR = 2.46, 95%CI = 1.20-5.29].	Arginine	75-78	collagen type IX alpha 2 chain	Homo sapiens	95-101
28002589-5	2016	Univariate and multivariate logistic regression analyses revealed that the Arg/Arg genotype of COL9A2 Gln326Arg was associated with increased risk of intervertebral disc disease in comparison to the Gln/Gln genotype [crude odds ratio (OR) = 2.25, 95% confidence interval (CI) = 1.12-4.62; adjusted OR = 2.46, 95%CI = 1.20-5.29].	Arginine	79-82	collagen type IX alpha 2 chain	Homo sapiens	95-101
27733068-8	2016	RESULTS: Mice submitted to l-arginine injections developed abdominal hyperalgesia and increased serum amylase, lipase, C-reactive protein and IL-6 concentrations; and increased pancreatic myeloperoxidase activity, edema index, MDA, and 3-nitrotyrosine contents.	Arginine	27-37	myeloperoxidase	Mus musculus	188-203
27593239-7	2016	This was accompanied by the improvement/restitution of eNOS and HO1 or MnSOD and GSH-Px protein expression levels in diabetic skin following L-arginine, i.e. SOD mimic treatments, respectively.	Arginine	141-151	superoxide dismutase 2	Rattus norvegicus	71-76
7827133-8	1995	Amino acid analysis of the modified gamma II-crystallin showed a loss of 47% of arginine residues.	Arginine	80-88	G protein subunit gamma 7	Bos taurus	36-44
27545444-7	2016	Calculating the formation of near-attack conformers resembling SN2 transition states leading to either the ADMA or SDMA products finds that Met48 and His293 may enable WT PRMT1 to yield ADMA exclusively by precluding MMA from binding in an orientation more conducive to SDMA formation, i.e., the methyl group bound at the arginine Neta2 position.	Arginine	322-330	protein arginine methyltransferase 1	Homo sapiens	171-176
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	33-41	T cell receptor beta variable 9	Homo sapiens	174-179
8536815-4	1995	The acceleration of healing by L-arginine was accompanied by a marked increase in gastric blood flow (GBF) at the ulcer margin, and an enhancement of serum gastrin level, mucosal DNA synthesis, and DNA and RNA contents and angiogenesis in the granulation tissue in the ulcer bed.	Arginine	31-41	gastrin	Homo sapiens	156-163
27426075-5	2016	We hypothesize that DMSO inhibits eNOS activity through modulation of its selective arginine supplier CAT-1.	Arginine	84-92	solute carrier family 7 member 1	Homo sapiens	102-107
8536815-7	1995	Addition of L-arginine to L-NNA restored ulcer healing, hyperemia at the ulcer margin and angiogenesis and prevented the fall in serum gastrin and mucosal growth caused by L-NNA.	Arginine	12-22	gastrin	Homo sapiens	135-142
8536815-10	1995	Our findings indicate that L-arginine accelerates ulcer healing due to its hyperemic, angiogenic and growth-promoting actions, possibly involving NO, gastrin and polyamines.	Arginine	27-37	gastrin	Homo sapiens	150-157
7607703-1	1995	Two HLA-B27 subtypes, B*2702 and B*2705, both associated with ankylosing spondylitis, were tested for binding affinity with a panel of polyalanine model nonapeptides carrying Arg at position 2 (P2) and a series of different amino acids at position 9 (P9).	Arginine	175-178	major histocompatibility complex, class I, B	Homo sapiens	4-11
7747130-8	1995	This means that probably the so called B pocket in the groove of HLA-B27 molecules, fixing the arginine at position 2 of the peptides which are presented to the receptors of cytotoxic T cells is of pathogenic importance.	Arginine	95-103	major histocompatibility complex, class I, B	Homo sapiens	65-72
7696618-3	1994	Comparison of genomic and cDNA sequences revealed extensive editing of the human EAA4 (GluR6) mRNA at the isoleucine/valine, tyrosine/cysteine sites of the transmembrane I region, and the glutamine/arginine site of the transmembrane II region.	Arginine	198-206	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	81-85
7696618-3	1994	Comparison of genomic and cDNA sequences revealed extensive editing of the human EAA4 (GluR6) mRNA at the isoleucine/valine, tyrosine/cysteine sites of the transmembrane I region, and the glutamine/arginine site of the transmembrane II region.	Arginine	198-206	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	87-92
7818496-10	1994	All of the above results consistently suggested that the binding-property of hnRNP protein A1 to single-stranded nucleic acid was significantly reduced subsequent to its arginine-methylation.	Arginine	170-178	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	77-82
7981186-1	1994	We have identified three novel mutations of the antithrombin (AT) gene in patients with thrombotic complications: a Cys 128 --> Tyr mutations, a G --> A mutation in the intervening sequence 4 (IVS4) 14 nucleotide 5" to exon 5, and a 9 bp deletion in the 3" end of exon 6 resulting in a short aberrant sequence after Arg 425.	Arginine	316-319	serpin family C member 1	Homo sapiens	48-60
7981186-1	1994	We have identified three novel mutations of the antithrombin (AT) gene in patients with thrombotic complications: a Cys 128 --> Tyr mutations, a G --> A mutation in the intervening sequence 4 (IVS4) 14 nucleotide 5" to exon 5, and a 9 bp deletion in the 3" end of exon 6 resulting in a short aberrant sequence after Arg 425.	Arginine	316-319	serpin family C member 1	Homo sapiens	62-64
7525557-7	1994	In order to further characterize the specific cell type producing NO, we used a NO-specific porphyrinic/Nafion-coated microsensor to record NO release from a single, isolated ARVM pretreated with IL-1 beta and IFN gamma in L-arginine-depleted medium.	Arginine	223-233	interferon gamma	Rattus norvegicus	210-219
7961684-6	1994	Amino-terminal sequence analysis indicated that cleavage of the mutant PAI-1 occurred at its reactive center P1-P1" Arg-Met bond.	Arginine	116-119	serpin family E member 1	Homo sapiens	71-76
7530691-7	1994	was stimulated by the cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), an effect enhanced by endotoxin [lipopolysaccharide (LPS)], reduced by the competitive inhibitor of L-arginine metabolism, NG-monomethyl-L-arginine (L-NMMA) and inhibited by cycloheximide.	Arginine	207-217	interferon gamma	Rattus norvegicus	32-48
7530691-7	1994	was stimulated by the cytokines interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), an effect enhanced by endotoxin [lipopolysaccharide (LPS)], reduced by the competitive inhibitor of L-arginine metabolism, NG-monomethyl-L-arginine (L-NMMA) and inhibited by cycloheximide.	Arginine	207-217	interferon gamma	Rattus norvegicus	50-59
7935475-8	1994	Interestingly, HRH1 but not Prp22 contains an arginine- and serine-rich domain (RS domain) which is characteristic of some splicing factors, such as members of the SR protein family.	Arginine	46-54	histamine receptor H1	Homo sapiens	15-19
7849700-3	1994	We have recently shown an unexpected correlation between one particular RET mutation, cys634--&gt;arg, and the probability of parathyroid involvement in families with MEN 2A.	Arginine	98-101	ret proto-oncogene	Homo sapiens	72-75
7849700-3	1994	We have recently shown an unexpected correlation between one particular RET mutation, cys634--&gt;arg, and the probability of parathyroid involvement in families with MEN 2A.	Arginine	98-101	ret proto-oncogene	Homo sapiens	167-173
7522258-4	1994	On the basis of this information, a peptide analogue (leucine 144/arginine 147), in which both of the major TCR contact residues were substituted, was synthesized.	Arginine	66-74	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	108-111
7532730-4	1994	NOS and arginine decarboxylase appear to be important for the effect of L-arginine on the circulatory system, since each produces nitric oxide (NO), a potent vasodilator, and agmatine, an endogenous noncatecholamine ligand for central alpha-2 adrenoceptors, from L-arginine.	Arginine	72-82	antizyme inhibitor 2	Homo sapiens	8-30
8063713-7	1994	The second substrate, NFF-2 (Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2, where Nva is norvaline), was hydrolyzed 60 times more rapidly by MMP-3 (kcat/Km = 59,400 s-1 M-1) than MMP-1.	Arginine	33-36	matrix metallopeptidase 1	Homo sapiens	186-191
8033887-4	1994	Two mutant urate oxidase proteins in which the C-terminal Ser-Arg-Leu (SRL) sequence was deleted or mutated to Ser-Glu-Leu (SEL) were not imported into peroxisomes.	Arginine	62-65	urate oxidase	Rattus norvegicus	11-24
8071113-4	1994	The cl-21 cDNA of Cyp1a-1 was found to have a single mutation leading to an amino acid substitution from Leu (118) to Arg (118).	Arginine	118-121	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	18-25
8011684-8	1994	Modification of the arginine residues of Lf with 1,2-cyclohexanedione abolished its ability to bind to AcLDL, suggesting that a region rich in basic amino acid residues near the N-terminus of Lf, which resembles the ligand-binding site of the scavenger receptor, may be responsible for this binding ability.	Arginine	20-28	lactotransferrin	Bos taurus	41-43
8011684-8	1994	Modification of the arginine residues of Lf with 1,2-cyclohexanedione abolished its ability to bind to AcLDL, suggesting that a region rich in basic amino acid residues near the N-terminus of Lf, which resembles the ligand-binding site of the scavenger receptor, may be responsible for this binding ability.	Arginine	20-28	lactotransferrin	Bos taurus	192-194
7516896-5	1994	As the amino acid sequence of p58 contains an arginine/serine (RS)-rich region similar to the RS-rich region found in SF 2, we speculate that these domains provide binding sites for p34 and that this protein may be a linker between the nuclear membrane and intranuclear spliceosomal substructures.	Arginine	46-54	cyclin dependent kinase 11B	Homo sapiens	30-33
8043104-0	1994	Pleiotropic function of ArgRIIIp (Arg82p), one of the regulators of arginine metabolism in Saccharomyces cerevisiae.	Arginine	68-76	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	34-40
8043104-2	1994	ArgRIIIp (Arg82p), together with ArgRIp (Arg80p), ArgRIIp (Arg81p) and Mcm1p, regulates the expression of arginine anabolic and catabolic genes.	Arginine	106-114	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	10-16
8043104-2	1994	ArgRIIIp (Arg82p), together with ArgRIp (Arg80p), ArgRIIp (Arg81p) and Mcm1p, regulates the expression of arginine anabolic and catabolic genes.	Arginine	106-114	Arg80p	Saccharomyces cerevisiae S288C	41-47
8043104-2	1994	ArgRIIIp (Arg82p), together with ArgRIp (Arg80p), ArgRIIp (Arg81p) and Mcm1p, regulates the expression of arginine anabolic and catabolic genes.	Arginine	106-114	transcription factor MCM1	Saccharomyces cerevisiae S288C	71-76
8043104-7	1994	Overexpression of Mcm1p in an argRIII-disrupted strain restores the mating competence of the strain, the ability to form a protein complex with P(PAL) DNA in vitro, and the regulation of arginine metabolism.	Arginine	187-195	transcription factor MCM1	Saccharomyces cerevisiae S288C	18-23
7513553-9	1994	We also studied the effect upon pY505 peptide binding of mutations at two highly conserved arginine residues in the lck SH2 domain (R134 and R154).	Arginine	91-99	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	116-119
26905697-1	2016	PURPOSE: Multimeric arginine-glycine-aspartic acid (RGD) peptides have advantages for imaging integrin alphavbeta3 expression.	Arginine	20-28	integrin subunit alpha V	Homo sapiens	94-114
8175650-7	1994	Arg-178 is an essential active site residue of thymidylate synthase that is donated from the opposing subunit of the dimer.	Arginine	0-3	thymidylate synthetase	Homo sapiens	47-67
27690003-1	2016	Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing.	Arginine	11-19	serine and arginine rich splicing factor 1	Homo sapiens	25-42
8161501-7	1994	The NMR spectrum and resulting solution structure of PAPA suggest that a side-chain to side-chain hydrogen bond involving an arginine and an aspartic acid analogous to one observed in the Zif268 protein-DNA cocrystal structure exists in solution in the absence of DNA [Pavletich, N. P., &amp; Pabo, C. O.	Arginine	125-133	early growth response 1	Homo sapiens	188-194
27500568-5	2016	The crystal structure of AtCaM7, and a model of the AtCAM7-Z-box complex suggest that Arg-127 determines the DNA-binding ability by forming crucial interactions with the guanine base.	Arginine	86-89	calmodulin 7	Arabidopsis thaliana	25-31
27500568-5	2016	The crystal structure of AtCaM7, and a model of the AtCAM7-Z-box complex suggest that Arg-127 determines the DNA-binding ability by forming crucial interactions with the guanine base.	Arginine	86-89	calmodulin 7	Arabidopsis thaliana	52-58
8150084-5	1994	Despite close similarity to GLP I, GLP III is expected to demonstrate different substrate specificity due to a substitution of the Arg residue by Glu at the critical position.	Arginine	131-134	granzyme B	Rattus norvegicus	35-42
28042453-1	2016	Coactivator-associated arginine methyltransferase 1 (CARM1) is a type I protein arginine methyltransferase (PRMT) that catalyzes the conversion of arginine into monomethylarginine (MMA) and further into asymmetric dimethylarginine (ADMA).	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
8192245-6	1994	The coexpression of glutaminase, glutamate dehydrogenase, and carbamoylphosphate synthase, but not of arginase, in the mesonephros and the small intestine suggests that these organs are involved in the biosynthesis of intermediates of the ornithine cycle, e.g., arginine or citrulline.	Arginine	262-270	glutaminase	Homo sapiens	20-56
8139542-0	1994	A segment of mRNA encoding the leader peptide of the CPA1 gene confers repression by arginine on a heterologous yeast gene transcript.	Arginine	85-93	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	53-57
8139542-1	1994	The expression of the yeast gene CPA1, which encodes the small subunit of the arginine pathway carbamoylphosphate synthetase, is repressed by arginine at a translational level.	Arginine	78-86	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	33-37
27558694-4	2016	RESULTS: Disruption of the carA gene (DeltacarA) which encodes the predicted small chain of carbamoylphosphate synthetase, resulted in arginine and pyrimidine auxotrophy in Pseudomonas syringae pv.	Arginine	135-143	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	Pseudomonas syringae pv. tomato str. DC3000	27-31
27558694-8	2016	The expression of carA was influenced by the concentrations of both arginine and uracil in the medium.	Arginine	68-76	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	Pseudomonas syringae pv. tomato str. DC3000	18-22
8139542-3	1994	Oligonucleotide site-directed mutagenesis of this uORF as well as sequencing of constitutive cis-dominant mutations has suggested that the leader peptide product of the CPA1 uORF is an essential negative element for repression of the CPA1 gene by arginine.	Arginine	247-255	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	169-173
27558694-12	2016	CONCLUSIONS: Our data show that carA plays an important role in providing arginine and uracil for growth of the bacteria and also influences other factors that are potentially important for growth and survival during infection.	Arginine	74-82	glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit	Pseudomonas syringae pv. tomato str. DC3000	32-36
8139542-3	1994	Oligonucleotide site-directed mutagenesis of this uORF as well as sequencing of constitutive cis-dominant mutations has suggested that the leader peptide product of the CPA1 uORF is an essential negative element for repression of the CPA1 gene by arginine.	Arginine	247-255	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	234-238
8139542-5	1994	The arginine-dependent repression of CPA1 was little affected in these constructions, indicating that these regions are not essential for the regulatory response.	Arginine	4-12	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	37-41
8139542-6	1994	This conclusion was further supported by the finding that inserting the mRNA segment encoding the leader peptide sequence of CPA1 in the leader sequence of another gene, namely, GCN4, places this gene under arginine repression.	Arginine	207-215	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	125-129
29782774-3	2016	The drug effect on NO-producing function of endothelium is due to the increased availability of L-arginine to NO-synthase (NOS-3), reduced level of atherogenesis risk factor (LDL cholesterol in serum), and increased expression of NOS-3 in vascular endothelium on the average by 30.5% (p = 0,001).	Arginine	96-106	nitric oxide synthase 3	Rattus norvegicus	123-128
8142362-3	1994	Three mutations that disrupt an ion pair, present in latent PAI-1, between Arg-30 and Glu-350 (P4"), were introduced into recombinant PAI-1.	Arginine	75-78	serpin family E member 1	Homo sapiens	60-65
27312592-9	2016	In contrast, changing the glutamine into an arginine rendered D. virilis Amyrel chloride-dependent, and interestingly, significantly increased its catalytic efficiency.	Arginine	44-52	alpha-amylase-related protein	Drosophila virilis	73-79
8142362-5	1994	However, the half-life of each purified PAI-1 mutant was extended compared to the 1.1 h observed for wild-type PAI-1 (wtPAI-1) (1.2 h for Glu-350--&gt;Arg, 2.0 h for Glu-350--&gt;Pro, and 2.1 h for the Arg-30--&gt;Glu mutation).	Arginine	151-154	serpin family E member 1	Homo sapiens	40-45
8142362-5	1994	However, the half-life of each purified PAI-1 mutant was extended compared to the 1.1 h observed for wild-type PAI-1 (wtPAI-1) (1.2 h for Glu-350--&gt;Arg, 2.0 h for Glu-350--&gt;Pro, and 2.1 h for the Arg-30--&gt;Glu mutation).	Arginine	202-205	serpin family E member 1	Homo sapiens	40-45
8142362-6	1994	An additional PAI-1 variant containing a second mutation designed to potentially reconstitute the ion pair (Arg-30--&gt;Glu, Glu-350--&gt;Arg) failed to restore the wild-type half-life.	Arginine	108-111	serpin family E member 1	Homo sapiens	14-19
8142362-6	1994	An additional PAI-1 variant containing a second mutation designed to potentially reconstitute the ion pair (Arg-30--&gt;Glu, Glu-350--&gt;Arg) failed to restore the wild-type half-life.	Arginine	138-141	serpin family E member 1	Homo sapiens	14-19
8122109-3	1994	A ts derivative of Arg-DHFR was identified that is long-lived at 23 degrees C but rapidly degraded by the N-end rule pathway at 37 degrees C. Fusions of ts Arg-DHFR to either Ura3 or Cdc28 of S. cerevisiae confer ts phenotypes specific for these gene products.	Arginine	19-22	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	183-188
8122109-3	1994	A ts derivative of Arg-DHFR was identified that is long-lived at 23 degrees C but rapidly degraded by the N-end rule pathway at 37 degrees C. Fusions of ts Arg-DHFR to either Ura3 or Cdc28 of S. cerevisiae confer ts phenotypes specific for these gene products.	Arginine	156-159	cyclin-dependent serine/threonine-protein kinase CDC28	Saccharomyces cerevisiae S288C	183-188
27486435-10	2016	Nonetheless, when protein synthesis was blocked with cycloheximide, MRAP was rapidly degraded even when MG132 was included and all lysines were replaced by arginines, implicating non-proteasomal degradation pathways.	Arginine	156-165	melanocortin-2 receptor accessory protein	Cricetulus griseus	68-72
8032321-2	1994	When supplementation with a minor tRNA(AGA/AGG)Arg encoded by the E. coli argU gene, the expression level of hGM-CSF was raised about 3-4-fold, although there is only one rare AGG codon in hGM-CSF cDNA gene.	Arginine	47-50	colony stimulating factor 2	Homo sapiens	109-116
26997641-1	2016	BACKGROUND: Recently, antibodies directed against peptidyl arginine deiminase 3 and 4 (anti-PAD3/PAD4 antibodies), calcium-dependent enzymes that catalyze the conversion from arginine to citrulline, have been described.	Arginine	59-67	peptidyl arginine deiminase 3	Homo sapiens	92-96
26768611-8	2016	The risk of gastric cancer was significantly elevated in individuals with XRCC1 Arg/Gln +Gln/Gln (p = 0.031; odds ratio = 2.32; 95 % confidence interval (CI) 1.07-5.06) and GSTP1 Val/Val genotype (p = 0.009; odds ratio = 8.64; 95 % CI 1.84-40.55).	Arginine	80-83	X-ray repair cross complementing 1	Homo sapiens	74-79
8032321-2	1994	When supplementation with a minor tRNA(AGA/AGG)Arg encoded by the E. coli argU gene, the expression level of hGM-CSF was raised about 3-4-fold, although there is only one rare AGG codon in hGM-CSF cDNA gene.	Arginine	47-50	colony stimulating factor 2	Homo sapiens	189-196
8010103-1	1994	This study was to investigate the protective effect of l-arginine, a precursor of endothelium-derived relaxing factor (EDRF), against damages due to endogenous or exogenous oxygen free radicals (OFR) on the aortic endothelium.	Arginine	55-65	alpha hemoglobin stabilizing protein	Homo sapiens	119-123
27185895-5	2016	In this study, we identify alternatively spliced Drosha transcripts that are devoid of a part of the arginine/serine-rich (RS-rich) domain and expressed in a large set of human cells.	Arginine	101-109	drosha ribonuclease III	Homo sapiens	49-55
27013146-5	2016	Three sulfate anions bound to RNase 6 were found, interacting with residues at the main active site (His(15), His(122) and Gln(14)) and cationic surface-exposed residues (His(36), His(39), Arg(66) and His(67)).	Arginine	189-192	ribonuclease A family member k6	Homo sapiens	30-37
7509596-1	1994	Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) is synthesized from L-Arginine by the endothelial, constitutive, NO synthase.	Arginine	81-91	alpha hemoglobin stabilizing protein	Homo sapiens	0-35
7509596-1	1994	Endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) is synthesized from L-Arginine by the endothelial, constitutive, NO synthase.	Arginine	81-91	alpha hemoglobin stabilizing protein	Homo sapiens	37-41
8108441-4	1994	Typical HLA-B27-binding peptides contain arginine in position 2.	Arginine	41-49	major histocompatibility complex, class I, B	Homo sapiens	8-15
26992901-9	2016	ADH1B His/Arg had an OR of 1.98 (1.20-3.24, P = 0.007) compared with His/His.	Arginine	10-13	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
26992901-10	2016	ADH1B Arg+ showed a similar OR and 95% CI.	Arginine	6-9	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
27126696-9	2016	This work also provides the first direct evidence of (1) intracellular cleavage at the Arg(1648) FVIII processing site promoted by wild-type PACE and PCSK7 and (2) proteolytic processing at the Arg(1648) FVIII processing site by PCSK6.	Arginine	87-90	proprotein convertase subtilisin/kexin type 6	Homo sapiens	229-234
8141293-9	1994	Addition of L-arginine (no effects alone) to L-NAME restored the responses to VN (to 100 +/- 21% of controls) and increased VIP responses (to 65 +/- 11%).	Arginine	12-22	vasoactive intestinal peptide	Sus scrofa	124-127
26947510-2	2016	Recently, Berendse et al reported an improvement of peroxisomal functions with l-arginine supplementation in fibroblasts with specific mutations of PEX1, PEX6, and PEX12.	Arginine	79-89	peroxisomal biogenesis factor 6	Homo sapiens	154-158
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Arginine	134-137	fibronectin 1	Mus musculus	43-54
27027728-6	2016	Four selected polymorphisms were determined: beta1 -adrenergic receptor polymorphisms Ser(49) Gly and Arg(389) Gly and beta2 -adrenergic receptor polymorphisms Arg(16) Gly and Gln(27) Glu.	Arginine	160-163	adrenoceptor beta 2	Homo sapiens	119-145
8123795-1	1994	We report the rescue of an arginine-requiring mutant (arg7-8) of Chlamydomonas reinhardtii by complementation using total DNA from a genomic cosmid library.	Arginine	27-35	uncharacterized protein	Chlamydomonas reinhardtii	54-58
27114555-2	2016	Symmetric arginine dimethylation mediated by PRMT5 modulates constitutive and alternative pre-mRNA splicing of diverse genes to regulate normal growth and development in multiple species; however, the underlying molecular mechanism remains largely unknown.	Arginine	10-18	SHK1 binding protein 1	Arabidopsis thaliana	45-50
8123795-4	1994	The arginine-independent phenotype is stable in the absence of selective pressure and high levels of ASL activity are detected in all four clones.	Arginine	4-12	uncharacterized protein	Chlamydomonas reinhardtii	101-104
8307152-2	1994	Extracts made from IL-1-stimulated KB cells phosphorylated recombinant hsp27, in vitro, on serine residues 78 and 82 which are contained within Arg-X-X-Ser motifs similar to those phosphorylated by the ribosomal protein S6 kinases.	Arginine	144-147	heat shock protein family B (small) member 1	Homo sapiens	71-76
8000074-3	1994	This partial sequence, homologous to human CPE, CPM, and CPN, contained the conserved arginine and zinc binding domains.	Arginine	86-94	carboxypeptidase E	Homo sapiens	43-46
8012714-12	1994	In a separate experiment (n = 8) we determined that the inhibitory effect of L-NAME on the hyperaemic vasodilator response to MgSO4 was prevented by L-arginine, and also demonstrated that the Beta2-adrenoceptor antagonist, ICI 118551, caused significant inhibition of the hindquarters haemodynamic effects of MgSO4.6.	Arginine	149-159	adrenoceptor beta 2	Rattus norvegicus	192-210
7496193-6	1994	Intrathecal injection of IFN-gamma causes in rats a sustained phase of nociceptive flexor reflex facilitation, which can be partially blocked by nitro-L-arginin-ester, an inhibitor of nitric oxide synthase, indicating that nociceptive effects of the IFN-gamma is mediated by activation of the L-arginin-nitric oxide pathway.	Arginine	151-160	interferon gamma	Rattus norvegicus	25-34
7954854-4	1994	Vimentins with modifications at or near a highly conserved tripeptide, arg-asp-gly (RDG), of the tail domain incorporated into existing IF networks in vimentin-expressing (vim+) cells, but were assembly-incompetent in cells that did not express IF proteins (vim-).	Arginine	71-74	vimentin	Homo sapiens	151-159
8003637-0	1994	Low-dose dietary L-arginine increases plasma interleukin 1 alpha but not interleukin 1 beta in patients with diabetes mellitus.	Arginine	17-27	interleukin 1 alpha	Homo sapiens	45-64
8003637-4	1994	Arginine supplementation in 29 patients with diabetes mellitus prompted a 2-fold increase of IL-1 alpha from baseline levels (P &lt; 0.001) while IL-1 beta was unaffected.	Arginine	0-8	interleukin 1 alpha	Homo sapiens	93-103
7906986-5	1994	The recurrent mutations affecting the first and second nucleotide of CGC coding for the normal Arg residue are support for the high mutability of CpG dinucleotides within the LPL gene.	Arginine	95-98	lipoprotein lipase	Homo sapiens	175-178
7507499-4	1994	To investigate the mechanisms by which SP suppressed BPO-specific IgE AFC responses were induced in vitro, these responses were induced by culturing spleen cells from BPO-KLH sensitized mice for 5 days with BPO-KLH with or without whole SP, amino terminal SP (SP 1-4: Arg-Lys-Pro-Lys), or carboxy terminal SP (SP 8-11: Phe-Gly-Leu-Met).	Arginine	268-271	tachykinin 1	Mus musculus	39-41
8036783-4	1994	C3a and C4a were measured as the native and des Arg form of each complement by radioimmunoassay.	Arginine	48-51	complement C4A (Rodgers blood group)	Homo sapiens	8-11
7903302-11	1993	The Arg-Lys sequence at positions 25-31, which resembles the binding site of apolipoprotein E, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor with high efficiency.	Arginine	4-7	lactotransferrin	Rattus norvegicus	136-147
7504656-4	1993	The Arg-Gly-Asp (RGD)-containing peptide, a major adhesive ligand of ECM, is present in various plasma and matrix glycoproteins, such as FN and VN.	Arginine	4-7	fibronectin 1	Mus musculus	137-139
8254036-1	1993	Osteopontin is a phosphorylated, sialic acid-rich, noncollagenous bone matrix protein containing the Arg-Gly-Asp-Ser amino acid sequence responsible for cell adhesion.	Arginine	101-104	secreted phosphoprotein 1	Homo sapiens	0-11
8249276-1	1993	A panel of mutants of the hepatitis B virus X gene (HBx) was constructed by oligonucleotide-directed insertion of two codons (Arg Pro) at 10- or 20-amino-acid intervals along the entire gene.	Arginine	126-129	X protein	Hepatitis B virus	26-50
8249276-1	1993	A panel of mutants of the hepatitis B virus X gene (HBx) was constructed by oligonucleotide-directed insertion of two codons (Arg Pro) at 10- or 20-amino-acid intervals along the entire gene.	Arginine	126-129	X protein	Hepatitis B virus	52-55
8250906-2	1993	The helix-stabilizing tendency of N-terminal amino acid in NPY (12-36) was found to be as follows: Thr &gt; Ser &gt; Gly &gt; Gln &gt; Cys &gt; Asn &gt; Asp &gt; Val &gt; Phe &gt; Glu &gt; Lys &gt; Tyr &gt; Ala = Trp &gt; His &gt; Arg, suggesting the importance of end capping.	Arginine	231-234	neuropeptide Y	Homo sapiens	59-62
7804366-4	1993	The data showed that a single amino acid substitution of tyrosine by phenylalanine and a number of amino acids including serine, asparagine, histidine and arginine at position 97 in the VH CDR3 region all resulted in approximate 18-fold lower binding affinity, whereas the substitution of tyrosine by phenylalanine at position 96 in the VH CDR3 region did not affect the binding affinity of the cB72.3m4 antibody.	Arginine	155-163	cerebellar degeneration-related 3	Mus musculus	189-193
7691613-0	1993	Overlapping epitopes encompassing a point mutation (12 Gly--&gt;Arg) in p21 ras can be recognized by HLA-DR, -DP and -DQ restricted T cells.	Arginine	64-67	H3 histone pseudogene 16	Homo sapiens	72-75
7691613-5	1993	By repeated in vitro stimulation of peripheral blood mononuclear cells, several T cells clones could be generated which recognized a p21 ras derived peptide carrying a position 12 Gly--&gt;Arg substitution.	Arginine	189-192	H3 histone pseudogene 16	Homo sapiens	133-136
8225311-0	1993	Deletion of arginine (608) in acid sphingomyelinase is the prevalent mutation among Niemann-Pick disease type B patients from northern Africa.	Arginine	12-20	protein interacting with PRKCA 1	Homo sapiens	92-96
8225311-8	1993	Our results indicate that deletion of arginine 608 in the acid sphingomyelinase gene is the highly prevalent mutation underlying Niemann-Pick type B disease in the population of Maghreb.	Arginine	38-46	protein interacting with PRKCA 1	Homo sapiens	137-141
8232202-1	1993	The ability of three mutant alleles of SLT2 generated by site-directed mutagenesis, namely E54 (glutamic acid), R54 (arginine) and F54 (phenylalanine), to complement slt2 mutants was tested.	Arginine	117-125	mitogen-activated serine/threonine-protein kinase SLT2	Saccharomyces cerevisiae S288C	39-43
7690756-4	1993	The Apn1 C terminus is rich in basic amino acids and includes two lysine/arginine clusters related to the nuclear transport signals of some other proteins.	Arginine	73-81	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	4-8
27058005-8	2016	We further determined that KNG1K438-R457 is cleaved at its C-terminal arginine by carboxypeptidase N1 (CPN1).	Arginine	70-78	carboxypeptidase N subunit 1	Homo sapiens	82-101
7692398-4	1993	A full-length cDNA clone for hnRNP G has been isolated and sequenced, and the predicted amino acid sequence for hnRNP G shows that it contains one RNP-consensus RNA binding domain (RBD) at the amino terminus and a carboxyl domain rich in serines, arginines and glycines.	Arginine	247-256	RBMX pseudogene 1	Homo sapiens	112-119
27058005-8	2016	We further determined that KNG1K438-R457 is cleaved at its C-terminal arginine by carboxypeptidase N1 (CPN1).	Arginine	70-78	carboxypeptidase N subunit 1	Homo sapiens	103-107
8257803-4	1993	In vitro studies revealed the potency of the MAP-1 structure to induce proliferation of HA1C[Arg]-primed T-cells, and in vivo studies demonstrated the protective feature of the immune response elicited by MAP-1 and to a lesser extent by the monomeric HA1C[Arg].	Arginine	93-96	mannosidase processing 1	Mus musculus	45-50
26940553-0	2016	Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.	Arginine	30-38	mucin 2	Mus musculus	119-122
8257803-4	1993	In vitro studies revealed the potency of the MAP-1 structure to induce proliferation of HA1C[Arg]-primed T-cells, and in vivo studies demonstrated the protective feature of the immune response elicited by MAP-1 and to a lesser extent by the monomeric HA1C[Arg].	Arginine	256-259	mannosidase processing 1	Mus musculus	45-50
8352742-5	1993	Observations of the in vivo processed patterns of these variant cytochrome b5 forms exported into the periplasm revealed that the absence of arginine was due to neither miscleavage of the translocated precursor by the signal peptidase nor the nature of the early region of cytochrome b5.	Arginine	141-149	cytochrome b5 type A	Homo sapiens	64-77
26863991-5	2016	L-Arg stimulated GLP-1 and PYY release in vitro and in vivo.	Arginine	0-5	glucagon	Rattus norvegicus	17-22
26863991-5	2016	L-Arg stimulated GLP-1 and PYY release in vitro and in vivo.	Arginine	0-5	peptide YY	Rattus norvegicus	27-30
26863991-7	2016	L-Arg-mediated PYY release modulated net ion transport across the gut mucosa.	Arginine	0-5	peptide YY	Rattus norvegicus	15-18
8343115-2	1993	Kinetic experiments demonstrated that inactivation of GSTP1-1 occurred upon reaction of one arginine residue per subunit with diacetyl, one lysine residue per subunit with 2,4,6-trinitrobenzene sulphonate, or one carboxylate group per subunit with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide.	Arginine	92-100	glutathione S-transferase pi 1	Homo sapiens	54-61
26923188-5	2016	The kinetic analysis and osteoclast differentiation assay showed that in addition to the sharp turn induced by the disulfide bond, two consecutive arginine residues were also important for binding to RANKL and inhibiting osteoclastogenesis.	Arginine	147-155	TNF superfamily member 11	Homo sapiens	200-205
26923188-6	2016	Docking and molecular dynamics simulations proposed the binding mode of the peptide to the RANKL trimer, showing that the arginine residues provide electrostatic interactions with RANKL and contribute to stabilizing the complex.	Arginine	122-130	TNF superfamily member 11	Homo sapiens	91-96
26923188-6	2016	Docking and molecular dynamics simulations proposed the binding mode of the peptide to the RANKL trimer, showing that the arginine residues provide electrostatic interactions with RANKL and contribute to stabilizing the complex.	Arginine	122-130	TNF superfamily member 11	Homo sapiens	180-185
8396955-2	1993	The evidence that the infusion of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), may reduce systemic blood pressure, via the generation of intracellular cyclic guanosine-3,5-monophosphate(cGMP), in normotensive volunteers is controversial.	Arginine	34-44	alpha hemoglobin stabilizing protein	Homo sapiens	63-98
26745957-0	2016	Effect of Cysteamine on Mutant ASL Proteins with Cysteine for Arginine Substitutions.	Arginine	62-70	argininosuccinate lyase	Homo sapiens	31-34
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	57-65	solute carrier family 38 member 9	Homo sapiens	10-17
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	86-94	solute carrier family 38 member 9	Homo sapiens	10-17
26972053-4	2016	Recently, SLC38A9 was identified as a putative lysosomal arginine sensor required for arginine to activate mTORC1 but how arginine deprivation represses mTORC1 is unknown.	Arginine	86-94	solute carrier family 38 member 9	Homo sapiens	10-17
26972053-5	2016	Here, we show that CASTOR1, a previously uncharacterized protein, interacts with GATOR2 and is required for arginine deprivation to inhibit mTORC1.	Arginine	108-116	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	19-26
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	0-8	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	22-29
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	0-8	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	59-66
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	116-124	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	22-29
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	116-124	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	59-66
26972053-7	2016	Arginine disrupts the CASTOR1-GATOR2 complex by binding to CASTOR1 with a dissociation constant of ~30 muM, and its arginine-binding capacity is required for arginine to activate mTORC1 in cells.	Arginine	158-166	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	22-29
26972053-8	2016	Collectively, these results establish CASTOR1 as an arginine sensor for the mTORC1 pathway.	Arginine	52-60	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	38-45
26851535-1	2016	Spiro sugar-isoxazolidines obtained by 1,3-dipolar cycloaddition of activated exo-glycals and nitrones were efficiently functionalized at two sites, i.e. C-4 and C-7, with arginine, arginine mimetics and guanidylated appendages.	Arginine	172-180	complement C7	Homo sapiens	162-165
26851535-1	2016	Spiro sugar-isoxazolidines obtained by 1,3-dipolar cycloaddition of activated exo-glycals and nitrones were efficiently functionalized at two sites, i.e. C-4 and C-7, with arginine, arginine mimetics and guanidylated appendages.	Arginine	182-190	complement C7	Homo sapiens	162-165
26692147-6	2016	Moreover, the presence of the Gln/Gln, Arg/His, and His/His genotypes of XRCC1 was significantly more likely to have bone erosion and extra-articular features in RA patients.	Arginine	39-42	X-ray repair cross complementing 1	Homo sapiens	73-78
26692147-10	2016	We concluded that the XRCC1-Arg/Gln, XRCC1-Arg/His, and OGG1 A/G polymorphism have a role in the development of rheumatoid arthritis disease.	Arginine	28-31	X-ray repair cross complementing 1	Homo sapiens	22-27
26692147-10	2016	We concluded that the XRCC1-Arg/Gln, XRCC1-Arg/His, and OGG1 A/G polymorphism have a role in the development of rheumatoid arthritis disease.	Arginine	43-46	X-ray repair cross complementing 1	Homo sapiens	37-42
27010893-0	2016	Enhanced expression of endothelial nitric oxide synthase in the myocardium ameliorates the progression of left ventricular hypertrophy in L-arginine treated Wistar-Kyoto rats.	Arginine	138-148	nitric oxide synthase 3	Rattus norvegicus	23-56
27010893-6	2016	However, in the LVH group treated with L-arginine there was up regulation of eNOS by almost 27% and down regulation in CSE by 24% when compared to control (all P &lt; 0.05).	Arginine	39-49	nitric oxide synthase 3	Rattus norvegicus	77-81
27010893-9	2016	The enhanced expression of eNOS in L-arginine treated LVH rats resulted in the amelioration of oxidative and haemodynamic parameters suggesting that NO system is an important therapeutic target in cardiac and LV hypertrophies.	Arginine	35-45	nitric oxide synthase 3	Rattus norvegicus	27-31
27239433-6	2016	Based on previous in vitro observation, we also introduced a single amino acid substitution in order to suppress stable FMBP-1-DNA binding; specifically, we replaced the ninth Arg in the third repeat within the STPR domain with Ala.	Arginine	176-179	fibroin-modulator-binding protein-1	Bombyx mori	120-126
26711145-0	2016	Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors.	Arginine	68-71	hepsin	Homo sapiens	99-105
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Arginine	78-81	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	71-74
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Arginine	78-81	teratocarcinoma-derived growth factor 1 pseudogene 5	Homo sapiens	151-154
26555266-8	2016	We present evidence that binding involves engagement of CR4 by Lys-88, CR5 by Arg-76 and Lys-80, and CR6 by Lys-69, with the strongest interactions to CR5 and CR6.	Arginine	78-81	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	159-162
27421901-0	2016	The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma.	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	32-37
27421901-0	2016	The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma.	Arginine	8-11	adrenoceptor beta 2	Homo sapiens	32-37
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Arginine	62-72	arginase 2	Homo sapiens	15-25
26482848-4	2015	Using peptide mass fingerprinting, we identified protein arginine N-methyltransferase 5 (PRMT5), a type II protein arginine N-methyltransferase that monomethylates and symmetrically dimethylates arginine residues, as a novel protein that interacts with RASSF1A.	Arginine	57-65	Ras association domain family member 1	Homo sapiens	253-260
26483203-4	2015	Our investigations of JX06 mechanism suggested that covalent modification at C240 induced conformational changes at Arginine 286 through Van der Waals forces, thereby hindering access of ATP to its binding pocket and in turn impairing PDK1 enzymatic activity.	Arginine	116-124	pyruvate dehydrogenase kinase 1	Homo sapiens	235-239
26238337-2	2015	We here report on the inhibitory effect of peptides containing multiple arginine residues on VIM-2, a clinically important MBL from Pseudomonas aeruginosa.	Arginine	72-80	VIM-2	Pseudomonas aeruginosa	93-98
26348775-2	2015	Arginine induced insulin secretion in mice as well as beta cell line, NIT-1, in which more than 90% of intracellular insulin is prionsulin without arginine cultivation.	Arginine	0-8	nitrilase 1	Mus musculus	70-75
26316623-5	2015	This phenotype was caused by a FLI1 homozygous c.970C&gt;T-point mutation that predicts an arginine-to-tryptophan substitution in the conserved ETS DNA-binding domain of FLI1.	Arginine	91-99	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	170-174
26397724-0	2015	Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636).	Arginine	83-91	C-X-C motif chemokine receptor 4	Homo sapiens	43-67
26397724-0	2015	Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636).	Arginine	83-91	C-X-C motif chemokine receptor 4	Homo sapiens	69-74
26397724-4	2015	Molecular docking of 1 to an X-ray structure of CXCR4 showed that the l-Arg guanidino group of 1 forms polar interactions with His(113) and Asp(171) and the (pyridin-2-ylmethyl)amino moiety is anchored by Asp(262) and His(281), whereas the naphthalene ring is tightly packed in a hydrophobic subpocket formed by the aromatic side chains of Trp(94), Tyr(45), and Tyr(116).	Arginine	70-75	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
26517932-4	2015	Studies carried out in several cultured cells clearly report that the TRIB3 Q84R missense polymorphism, is a gain-of-function amino acid substitution, with the Arg(84) variant being a stronger inhibitor of insulin-mediated AKT activation as compared with the more frequent Gln(84) variant.	Arginine	160-163	tribbles pseudokinase 3	Homo sapiens	70-75
26517932-7	2015	Accordingly with in vitro studies, in vivo studies indicate that TRIB3 Arg(84) is associated with insulin resistance, T2DM and several aspects of atherosclerosis, including overt CVD.	Arginine	71-74	tribbles pseudokinase 3	Homo sapiens	65-70
26517932-8	2015	In all, several data indicate that the TRIB3 Arg(84) variant plays a role on several aspects of glucose homoeostasis and atherosclerotic processes, thus unravelling new molecular pathogenic mechanisms of highly prevalent disorders such as T2DM and CVD.	Arginine	45-48	tribbles pseudokinase 3	Homo sapiens	39-44
26491644-1	2015	A dual-action ligand targeting both integrin alphaVbeta3 and vascular endothelial growth factor receptors (VEGFRs), was synthesized via conjugation of a cyclic peptidomimetic alphaVbeta3 Arg-Gly-Asp (RGD) ligand with a decapentapeptide.	Arginine	187-190	integrin subunit alpha V	Homo sapiens	36-56
26018935-2	2015	Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling.	Arginine	68-77	linker for activation of T cells	Mus musculus	51-54
26018935-2	2015	Previous studies demonstrated that substitution of LAT lysines with arginines (2KR LAT) resulted in decreased LAT ubiquitination and elevated T-cell signaling, indicating that LAT ubiquitination is a molecular checkpoint for attenuation of T-cell signaling.	Arginine	68-77	linker for activation of T cells	Mus musculus	83-86
26175157-5	2015	We identify two additional residues in mesotrypsin, Lys-74 and Asp-97, which in concert with Arg-193 and Ser-39 confer the full catalytic capability of mesotrypsin for proteolysis of BPTI and APPI.	Arginine	93-96	spleen trypsin inhibitor I	Bos taurus	183-187
26251449-5	2015	In the present study, we demonstrate, for the first time, the differences in the activation of soluble and membrane bound meprin beta and suggest transmembrane serine protease 6 [TMPRSS6 or matriptase-2 (MT2)] as a new potent activator, cleaving off the propeptide of meprin beta between Arg(61) and Asn(62) as determined by MS. We show that MT2, but not TMPRSS4 or pancreatic trypsin, is capable of activating full-length meprin beta at the cell surface, analysed by specific fluorogenic peptide cleavage assay, Western blotting and confocal laser scanning microscopy (CLSM).	Arginine	288-291	meprin A subunit beta	Homo sapiens	122-133
26179907-0	2015	Histone Arginine Methylation by PRMT7 Controls Germinal Center Formation via Regulating Bcl6 Transcription.	Arginine	8-16	B cell leukemia/lymphoma 6	Mus musculus	88-92
25934105-8	2015	In addition, the interference currents of glycin, ascorbic acid, histidine, uric acid, dopamine, arginine, and fructose on GOx biosensor were investigated.	Arginine	97-105	hydroxyacid oxidase 1	Homo sapiens	123-126
26056729-13	2015	We suggest that the 399 Arg/Gln polymorphism of the XRCC1 gene may serve as a predictive risk factor of POAG.	Arginine	24-27	X-ray repair cross complementing 1	Homo sapiens	52-57
8396955-2	1993	The evidence that the infusion of L-arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), may reduce systemic blood pressure, via the generation of intracellular cyclic guanosine-3,5-monophosphate(cGMP), in normotensive volunteers is controversial.	Arginine	34-44	alpha hemoglobin stabilizing protein	Homo sapiens	100-104
8251951-10	1993	Interestingly, ASTP can bind to the arginine-rich histones H3 and H4, to which activated GRC also binds.	Arginine	36-44	glycerol kinase	Rattus norvegicus	15-19
26379826-0	2015	Effect of L-arginine supplementation on insulin resistance and serum adiponectin concentration in rats with fat diet.	Arginine	10-20	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	69-80
26379826-1	2015	OBJECT: The purpose of this study was to determine whether supplementation with L-arginine, a substrate used in the production of nitric oxide, had an effect on adiponectin concentration in rats fed a high-fat diet.	Arginine	80-90	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	161-172
8318017-5	1993	mPC1 and hPC1 displayed identical cleavage selectivity towards a number of fluorogenic substrates, and those incorporating an Arg at the P4 site were most favoured.	Arginine	126-129	proprotein convertase subtilisin/kexin type 1	Homo sapiens	9-13
26379826-8	2015	An increase in cholesterol, triglycerides, insulin and HOMA-IR, as well as a decrease in NO and adiponectin were seen in group 2, while in group 3, L-arginine supplementation ameliorated these disturbances.	Arginine	148-158	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	96-107
8322890-1	1993	In the rat kidney, arginine (Arg) synthesis is restricted to the proximal tubule with a decreasing intensity from its convoluted (PCT) to its straight part (PST).	Arginine	19-27	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	157-160
8322890-1	1993	In the rat kidney, arginine (Arg) synthesis is restricted to the proximal tubule with a decreasing intensity from its convoluted (PCT) to its straight part (PST).	Arginine	29-32	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	157-160
8322890-13	1993	Thus Arg produced by PCT in both species is probably released in the cortical blood, whereas Arg produced in PST may serve locally to produce urea and ornithine, and the latter could be used for polyamine synthesis.	Arginine	93-96	sulfotransferase family 1A, phenol-preferring, member 1	Mus musculus	109-112
8398833-3	1993	A hydrophilic cluster of many Arg and Lys residues, found adjacent to the active site cleft, is proposed to be involved in thrombomodulin and/or protein S interactions.	Arginine	30-33	thrombomodulin	Homo sapiens	123-137
8347808-3	1993	Furthermore, the replacement by glutamine or arginine of the conserved asparagine residue in segment M2 of the epsilon 2 and zeta 1 NMDA receptor channel subunits reduced the sensitivities to PCP, ketamine and SKF-10,047, though to different extents.	Arginine	45-53	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	132-145
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Arginine	0-8	complement C1q A chain	Homo sapiens	51-54
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Arginine	0-8	complement C1q A chain	Homo sapiens	197-200
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Arginine	300-308	complement C1q A chain	Homo sapiens	51-54
8486696-0	1993	Arginine residues of the globular regions of human C1q involved in the interaction with immunoglobulin G. The immunoglobulin G binding site in the globular regions of human complement subcomponent C1q has been investigated by chemical modification of histidine residues with diethylpyrocarbonate and arginine residues with phenylglyoxal and cyclohexane-1,2-dione (CHD).	Arginine	300-308	complement C1q A chain	Homo sapiens	197-200
8486696-4	1993	Enzymic digestion and isolation of the modified peptides indicate that the modification by CHD of 4 to 5 arginine residues (A162, B114, B129, C156, and possibly B163) per C1q globular "head" abolishes the ability of C1q to interact with immune complexes.	Arginine	105-113	complement C1q A chain	Homo sapiens	171-174
8486696-4	1993	Enzymic digestion and isolation of the modified peptides indicate that the modification by CHD of 4 to 5 arginine residues (A162, B114, B129, C156, and possibly B163) per C1q globular "head" abolishes the ability of C1q to interact with immune complexes.	Arginine	105-113	complement C1q A chain	Homo sapiens	216-219
7683646-9	1993	Although substitution of residues 54 and 55 with the analogous residues from IGF-I (Arg-Arg) abolished binding to the IGF-II/mannose 6-phosphate receptor, binding to IGFBPs was not substantially affected.	Arginine	84-87	insulin like growth factor 2	Homo sapiens	118-124
7683646-9	1993	Although substitution of residues 54 and 55 with the analogous residues from IGF-I (Arg-Arg) abolished binding to the IGF-II/mannose 6-phosphate receptor, binding to IGFBPs was not substantially affected.	Arginine	88-91	insulin like growth factor 2	Homo sapiens	118-124
8492723-1	1993	To evaluate the relationship between the development of obesity and the hypersecretion of amylin by the pancreas, we examined the effects of 16.7 mmol/L glucose and 10 mmol/L arginine on the secretion of amylin and insulin by isolated perfused pancreata from genetically obese (fa/fa) and lean (Fa/?)	Arginine	175-183	islet amyloid polypeptide	Rattus norvegicus	204-210
8492723-4	1993	Pancreata of obese rats secreted greater amounts of amylin in response to 16.7 mmol/L glucose and 10 mmol/L arginine than did those of lean rats at all ages.	Arginine	108-116	islet amyloid polypeptide	Rattus norvegicus	52-58
8492723-8	1993	However, the relative amount of amylin to insulin secreted following stimulation with 16.7 mmol/L glucose and 10 mmol/L arginine in obese rats exceeded that in lean rats at all ages.	Arginine	120-128	islet amyloid polypeptide	Rattus norvegicus	32-38
8492723-9	1993	Differences in the secreted amylin to insulin molar ratios between obese and lean rats were significant when pancreata were stimulated with glucose at 18 weeks (obese, 1.23% +/- 0.05%; lean, 0.99% +/- 0.04%; P &lt; .01), glucose at 54 weeks (P &lt; .01), and arginine at 54 weeks (P &lt; .05).	Arginine	259-267	islet amyloid polypeptide	Rattus norvegicus	28-34
7682570-8	1993	The stimulatory effect on NOx and cGMP production by ETB agonist was inhibited by NO synthase inhibitor monomethyl-L-arginine; this effect was reversed by coaddition of L-arginine, but not D-arginine.	Arginine	115-125	endothelin receptor type B	Bos taurus	53-56
8468556-2	1993	The mutations were made by site-directed mutagenesis to alter basic amino acids (lysine or arginine) in the surface glycoprotein gp70.	Arginine	91-99	embigin	Mus musculus	129-133
8383684-3	1993	Peptides derived from the sequence of RK were used to prepare site-specific anti-peptide antibodies against: 1) the N-terminal region located between residues 17 and 34, which contains an autophosphorylation site; 2) the Lys/Arg-rich region corresponding to residues 216-237 near the catalytic domain; 3) the region located between residues 483 and 497, which encompasses the major autophosphorylation sites; and 4) the C-terminal region located between residues 539 and 556, close to the isoprenylation site of RK.	Arginine	225-228	G protein-coupled receptor kinase 1	Homo sapiens	38-40
8477949-4	1993	Amylin did not alter glucose-stimulated secretion of insulin but significantly inhibited arginine-stimulated secretion of insulin (control: 20.9 +/- 1.4 pmol/min; amylin group: 14.8 +/- 1.6 pmol/min, p &lt; 0.05).	Arginine	89-97	islet amyloid polypeptide	Rattus norvegicus	0-6
8477949-4	1993	Amylin did not alter glucose-stimulated secretion of insulin but significantly inhibited arginine-stimulated secretion of insulin (control: 20.9 +/- 1.4 pmol/min; amylin group: 14.8 +/- 1.6 pmol/min, p &lt; 0.05).	Arginine	89-97	islet amyloid polypeptide	Rattus norvegicus	163-169
8461525-7	1993	By increasing EDRF production or inhibiting its breakdown, EDRF precursors such as L-arginine, the superoxide radical scavenger superoxide dismutase, nitroglycerin, and nitroprusside all cause vasodilation by increasing NO levels in the setting of myocardial ischemia.	Arginine	83-93	alpha hemoglobin stabilizing protein	Homo sapiens	14-18
8461525-7	1993	By increasing EDRF production or inhibiting its breakdown, EDRF precursors such as L-arginine, the superoxide radical scavenger superoxide dismutase, nitroglycerin, and nitroprusside all cause vasodilation by increasing NO levels in the setting of myocardial ischemia.	Arginine	83-93	alpha hemoglobin stabilizing protein	Homo sapiens	59-63
8436905-1	1993	HLA-B27 subtypes share many structural features, including their pocket B, which interacts with a conserved Arg residue at the second position of B*2705-bound peptides.	Arginine	108-111	major histocompatibility complex, class I, B	Homo sapiens	0-7
8460100-3	1993	Recently, IAPP has been reported to inhibit glucose-stimulated insulin release from isolated rat islets and to be released in response to glucose and arginine.	Arginine	150-158	islet amyloid polypeptide	Rattus norvegicus	10-14
7678002-6	1993	Substrate specificity studies using synthetic and peptide substrates indicated that the enzyme preferentially hydrolyzes Arg-X bonds and, to a much lesser extent, Lys-X bonds, and is apparently distinct from thrombin, kallikrein, plasmin, and other trypsin-like proteinases so far reported including tryptase.	Arginine	121-124	plasminogen	Bos taurus	230-237
8480530-1	1993	Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines.	Arginine	81-91	interferon gamma	Rattus norvegicus	56-72
8480530-1	1993	Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines.	Arginine	81-91	interferon gamma	Rattus norvegicus	177-193
7828447-5	1993	Progressive inhibition of EDRF was achieved by continuous infusion of the substituted L-arginine analog N-nitro-L-arginine (NNLA).	Arginine	86-96	alpha hemoglobin stabilizing protein	Homo sapiens	26-30
11607345-1	1993	Electron microscopic observation provides insight into the nature of the polymeric supramolecular liquid crystalline species (TP2, TU2)n formed by polyassociation of the complementary components TP2 and TU2 derived from D-, L-, or meso-tartaric acid (where T is any form of tartaric acid, D is the D species, and L is the L species) and from pyridine (P) and uracil (U) derivatives.	Arginine	224-226	transition protein 2	Homo sapiens	126-129
25907447-3	2015	infusion of pre-aggregated Abeta25-35 (the neurotoxic domain of the full-length Abeta) altered arginine metabolism in the rat hippocampus (particularly the CA2/3 and dentate gyrus (DG) sub-regions) and prefrontal cortex (PFC) at the time point of 8 days post-infusion.	Arginine	95-103	amyloid beta precursor protein	Rattus norvegicus	27-32
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Arginine	168-171	insulin like growth factor 2	Homo sapiens	18-55
25740291-9	2015	The nNOS expression in the non clipped kidney was significantly increased in 2K1C ALSK+L-ARG rats.	Arginine	87-92	nitric oxide synthase 1	Rattus norvegicus	4-8
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Arginine	238-241	insulin like growth factor 2	Homo sapiens	18-55
26068232-4	2015	A bifunctional enzyme was identified in certain bacteria, which catalyzes both NAGS and N-acetylglutamate kinase (NAGK) activities, the first two steps of the arginine biosynthetic pathway.	Arginine	159-167	N-acetylglutamate synthase	Homo sapiens	79-83
26020839-5	2015	Moreover, we define the arginines within the RGG/RG motifs as the site of methylation by PRMT1 both in vitro and in vivo.	Arginine	24-33	protein arginine methyltransferase 1	Homo sapiens	89-94
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Arginine	238-241	insulin like growth factor 2	Homo sapiens	18-55
1282887-2	1992	A mutant of human insulin-like growth factor II (IGF II) was constructed by site-directed mutagenesis: the nucleotides coding for Ser33 and Ser39 were changed to yield Arg and Lys, respectively, thus creating two pairs of basic residues, Arg-Arg and Lys-Arg, as flanking sequences of the remaining C domain.	Arginine	238-241	insulin like growth factor 2	Homo sapiens	18-55
1332957-6	1992	These results suggest that Arg-70 in the anion-binding exosite of thrombin is a key determinant for interaction with specific single-stranded DNA molecules, and that binding of single-stranded DNA molecules to the exosite prevents the interaction of thrombin with fibrinogen, the platelet thrombin receptor, and thrombomodulin.	Arginine	27-30	thrombomodulin	Homo sapiens	312-326
1299245-0	1992	A family case of beta-thalassemia minor and hemoglobin Queens: alpha 34 (B15) Leu-Arg.	Arginine	82-85	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	73-76
25993630-2	2015	METHODS: We performed a case control study in 3 MELAS siblings (m.3243A&gt;G tRNA(leu(UUR)) in MTTL1 gene) with different % blood mutant mtDNA to evaluate total body maximal aerobic capacity (VO(2peak)) using graded cycle ergometry and muscle metabolism using 31P-MRS. We then ran a clinical trial pilot study in MELAS sibs to assess response of these parameters to single dose and a 6-week steady-state trial of oral L-Arginine.	Arginine	418-428	mitochondrially encoded tRNA leucine 1 (UUA/G)	Homo sapiens	95-100
1299245-4	1992	Incidentally, an alpha chain variant with a high isoelectric point was also found in two other family members without clinical problems and was finally identified as alpha 34 (B15) Leu-Arg or Hemoglobin Queens.	Arginine	185-188	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	176-179
25748791-0	2015	PRMT1-mediated arginine methylation controls ATXN2L localization.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	0-5
1341708-1	1992	Mechanisms of cathepsin B activation involved in methionine-enkephalin (ME) production induced by bradykinin (BK), des-Arg9-BK or L-arginine (L-Arg) were studied using cultured fibroblasts of the rat dental pulp, especially from a viewpoint of intracellular signal transduction.	Arginine	130-140	cathepsin B	Rattus norvegicus	14-25
25748791-2	2015	Recent proteomic mass spectrometry studies reported arginine methylation of ataxin-2-like (ATXN2L), the paralog of ataxin-2, a protein that is implicated in the neurodegenerative disorder spinocerebellar ataxia type 2.	Arginine	52-60	ataxin 2	Homo sapiens	76-84
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	22-27
1341708-1	1992	Mechanisms of cathepsin B activation involved in methionine-enkephalin (ME) production induced by bradykinin (BK), des-Arg9-BK or L-arginine (L-Arg) were studied using cultured fibroblasts of the rat dental pulp, especially from a viewpoint of intracellular signal transduction.	Arginine	130-140	proenkephalin	Rattus norvegicus	60-70
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	85-90
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	22-27
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	85-90
1341708-1	1992	Mechanisms of cathepsin B activation involved in methionine-enkephalin (ME) production induced by bradykinin (BK), des-Arg9-BK or L-arginine (L-Arg) were studied using cultured fibroblasts of the rat dental pulp, especially from a viewpoint of intracellular signal transduction.	Arginine	142-147	cathepsin B	Rattus norvegicus	14-25
1341708-1	1992	Mechanisms of cathepsin B activation involved in methionine-enkephalin (ME) production induced by bradykinin (BK), des-Arg9-BK or L-arginine (L-Arg) were studied using cultured fibroblasts of the rat dental pulp, especially from a viewpoint of intracellular signal transduction.	Arginine	142-147	proenkephalin	Rattus norvegicus	60-70
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-7
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	24-29
1341708-3	1992	The activation of cathepsin B by BK or des-Arg9-BK was inhibited by des-Arg9-[Leu8]-BK or islet-activating protein (IAP), and the activation of cathepsin B by L-Arg was inhibited by Leu-Arg (kyotorphin-receptor antagonist) or Botulinum C3-enzyme.	Arginine	159-164	cathepsin B	Rattus norvegicus	18-29
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	31-35
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-29
1341708-3	1992	The activation of cathepsin B by BK or des-Arg9-BK was inhibited by des-Arg9-[Leu8]-BK or islet-activating protein (IAP), and the activation of cathepsin B by L-Arg was inhibited by Leu-Arg (kyotorphin-receptor antagonist) or Botulinum C3-enzyme.	Arginine	159-164	cathepsin B	Rattus norvegicus	144-155
25814671-6	2015	The Abl family kinases, c-Abl (Abl1) and Abl related gene (Arg, Abl2), phosphorylate several cytoskeletal effectors that mediate vascular permeability, including nonmuscle myosin light chain kinase, cortactin, vinculin, and beta-catenin.	Arginine	59-62	cortactin	Homo sapiens	199-208
1341708-7	1992	These results indicate that phospholipase C and serine/threonine kinases are involved in the activation of cathepsin B by BK, des-Arg9-BK or L-Arg.	Arginine	141-146	cathepsin B	Rattus norvegicus	107-118
1341708-8	1992	Genistein inhibited the activation of cathepsin B by des-Arg9-BK or L-Arg in a different fashion, suggesting that tyrosine kinase(s) is also involved in the activation.	Arginine	68-73	cathepsin B	Rattus norvegicus	38-49
1341708-9	1992	Cathepsin B activation by BK or L-Arg but not des-Arg9-BK was inhibited by L-NMMA (inhibitor of NO synthesis), and the activation by L-Arg was enhanced by beta-glycerophosphate (beta-GP: inhibitor of phosphatases), while the activation by BK or des-Arg9-BK was inhibited by beta-GP.	Arginine	32-37	cathepsin B	Rattus norvegicus	0-11
1341708-9	1992	Cathepsin B activation by BK or L-Arg but not des-Arg9-BK was inhibited by L-NMMA (inhibitor of NO synthesis), and the activation by L-Arg was enhanced by beta-glycerophosphate (beta-GP: inhibitor of phosphatases), while the activation by BK or des-Arg9-BK was inhibited by beta-GP.	Arginine	133-138	cathepsin B	Rattus norvegicus	0-11
1341708-10	1992	These results suggest that BK-induced cathepsin B activation in the fibroblasts may be due to a combined effect of des-Arg9-BK and L-Arg.	Arginine	131-136	cathepsin B	Rattus norvegicus	38-49
1283417-5	1992	Endothelium derived relaxing factor (EDRF) was believed to be nitric oxide, was synthesized by nitric oxide (NO) synthase from L-arginine.	Arginine	127-137	alpha hemoglobin stabilizing protein	Homo sapiens	0-35
25434615-5	2015	For instance, Th1 levels of the minor alleles of GR TthIIII (AA) and IFNGR2 Q64R (Arg/Arg) groups were positively associated with chronic stress (PSS) (p = 0.024 and 0.005, respectively) compared with wild type (WT) and negatively associated with PSS in the heterozygous genotypes of GR BclI and IL4R Ile50Val (p = 0.040 and p = 0.052, respectively).	Arginine	82-85	interferon gamma receptor 2	Homo sapiens	69-75
25434615-5	2015	For instance, Th1 levels of the minor alleles of GR TthIIII (AA) and IFNGR2 Q64R (Arg/Arg) groups were positively associated with chronic stress (PSS) (p = 0.024 and 0.005, respectively) compared with wild type (WT) and negatively associated with PSS in the heterozygous genotypes of GR BclI and IL4R Ile50Val (p = 0.040 and p = 0.052, respectively).	Arginine	82-85	interleukin 4 receptor	Homo sapiens	296-300
25434615-5	2015	For instance, Th1 levels of the minor alleles of GR TthIIII (AA) and IFNGR2 Q64R (Arg/Arg) groups were positively associated with chronic stress (PSS) (p = 0.024 and 0.005, respectively) compared with wild type (WT) and negatively associated with PSS in the heterozygous genotypes of GR BclI and IL4R Ile50Val (p = 0.040 and p = 0.052, respectively).	Arginine	86-89	interferon gamma receptor 2	Homo sapiens	69-75
25682972-12	2015	EG-induced alterations in electrocardiographic (QRS interval, HR, and ST height) and hemodynamic (SBP, DBP, MABP, and LVEDP) abnormalities were significantly restored by L-arginine (500 and 1000 mg/kg) treatment.	Arginine	170-180	D-box binding PAR bZIP transcription factor	Rattus norvegicus	103-106
1283417-5	1992	Endothelium derived relaxing factor (EDRF) was believed to be nitric oxide, was synthesized by nitric oxide (NO) synthase from L-arginine.	Arginine	127-137	alpha hemoglobin stabilizing protein	Homo sapiens	37-41
1431106-8	1992	These results indicate that IFN-gamma plus IL-2-induced tumoricidal activity is dependent upon the metabolism of L-arginine to reactive nitrogen intermediates, and they establish a role for TNF-alpha as a required intermediate for IL-2-dependent NO2- production and tumoricidal activity.	Arginine	113-123	interleukin 2	Mus musculus	43-47
25765074-8	2015	Expression of the protein arginine methyltransferase (PRMT) genes PRMT1, PRMT3 and PRMT5 throughout development was not affected by arginine.	Arginine	26-34	protein arginine methyltransferase 1	Homo sapiens	66-71
1331047-6	1992	The two peptides, particularly IIFMGRVANP, directly enhanced the amidolytic activity of thrombin and Factor Xa on the synthetic substrate Boc-Ala-Gly-Arg-MCA (where Boc is t-butoxycarbonyl and MCA is 4-methylcoumarin), which corresponds to residues P3-P1 of the reactive site of antithrombin III, and also on other substrates due to increased Vmax.	Arginine	150-153	serpin family C member 1	Homo sapiens	279-295
25792604-3	2015	The conserved eukaryotic Asc1 protein limits translation through internal Arg CGA codon repeats.	Arginine	74-77	guanine nucleotide-binding protein subunit beta	Saccharomyces cerevisiae S288C	25-29
25490258-5	2015	APC3"s TPR motifs recruit substrate-binding coactivators, CDC20 and CDH1, via their C-terminal conserved Ile-Arg (IR) tail sequences.	Arginine	109-112	cell division cycle 20	Homo sapiens	58-63
25724897-9	2015	The primary KLK4 cleavage site in murine ephrin-B2 was verified and shown to correspond to one of the in silico predicted sites between extracellular domain residues arginine 178 and asparagine 179.	Arginine	166-174	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	12-16
1394884-5	1992	It was observed that the cytokines, interferon-gamma and tumor necrosis factor-alpha, synergistically induced an arginine-dependent production of NO in these cells.	Arginine	113-121	interferon gamma	Rattus norvegicus	36-84
1358204-4	1992	Interestingly, the HOX4A protein has a sequence, Pro-Ala-Ser-Gln-Ser-Pro-Glu-Arg-Ser, eight amino acids downstream from the homeodomain, which is similar to that containing a phosphorylation site in pp60c-src, Pro-Ala-Ser-Gln-Thr-Pro-Asn-Lys-Thr.	Arginine	77-80	homeobox D3	Homo sapiens	19-24
1486236-3	1992	Certain metabolite sequences including Gly, Asp, Arg, and Ser (GAAS) proved to be critical for cell interactions, e.g. with fibronectin.	Arginine	49-52	fibronectin 1	Mus musculus	124-135
1326547-0	1992	Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain.	Arginine	0-3	complement C2	Rattus norvegicus	85-88
1326547-0	1992	Arg-257 and Arg-307 of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase bind the C-2 phospho group of fructose-2,6-bisphosphate in the fructose-2,6-bisphosphatase domain.	Arginine	12-15	complement C2	Rattus norvegicus	85-88
1326547-16	1992	The results indicate that both Arg-257 and Arg-307 interact with the reactive C-2 phospho group of fructose 2,6-bisphosphate and that Arg-307 stabilizes this phospho group in the transition state during phosphoenzyme breakdown, whereas Arg-257 stabilizes the phospho group of the ground state phosphoenzyme intermediate.	Arginine	31-34	complement C2	Rattus norvegicus	78-81
1326547-16	1992	The results indicate that both Arg-257 and Arg-307 interact with the reactive C-2 phospho group of fructose 2,6-bisphosphate and that Arg-307 stabilizes this phospho group in the transition state during phosphoenzyme breakdown, whereas Arg-257 stabilizes the phospho group of the ground state phosphoenzyme intermediate.	Arginine	43-46	complement C2	Rattus norvegicus	78-81
1326547-16	1992	The results indicate that both Arg-257 and Arg-307 interact with the reactive C-2 phospho group of fructose 2,6-bisphosphate and that Arg-307 stabilizes this phospho group in the transition state during phosphoenzyme breakdown, whereas Arg-257 stabilizes the phospho group of the ground state phosphoenzyme intermediate.	Arginine	43-46	complement C2	Rattus norvegicus	78-81
1326547-16	1992	The results indicate that both Arg-257 and Arg-307 interact with the reactive C-2 phospho group of fructose 2,6-bisphosphate and that Arg-307 stabilizes this phospho group in the transition state during phosphoenzyme breakdown, whereas Arg-257 stabilizes the phospho group of the ground state phosphoenzyme intermediate.	Arginine	43-46	complement C2	Rattus norvegicus	78-81
1381287-3	1992	Two of six distinct incidences of EH had a keratin 10 (K10) point mutation in a highly conserved arginine.	Arginine	97-105	keratin 10	Homo sapiens	43-53
1381287-3	1992	Two of six distinct incidences of EH had a keratin 10 (K10) point mutation in a highly conserved arginine.	Arginine	97-105	keratin 10	Homo sapiens	55-58
1319348-6	1992	The expression levels of connexin26, connexin32, or connexin43 mRNAs were altered by the addition of fetal calf serum or arginine or by the absence of hydrocortisone in MX83 medium, all of which contributed to the shift in phenotype.	Arginine	121-129	gap junction protein, beta 2	Mus musculus	25-35
1319348-6	1992	The expression levels of connexin26, connexin32, or connexin43 mRNAs were altered by the addition of fetal calf serum or arginine or by the absence of hydrocortisone in MX83 medium, all of which contributed to the shift in phenotype.	Arginine	121-129	gap junction protein, beta 1	Mus musculus	37-47
1319348-6	1992	The expression levels of connexin26, connexin32, or connexin43 mRNAs were altered by the addition of fetal calf serum or arginine or by the absence of hydrocortisone in MX83 medium, all of which contributed to the shift in phenotype.	Arginine	121-129	gap junction protein, beta 1	Mus musculus	52-62
1597458-10	1992	The role of arginine residues on lactoferrin was studied by modifying these residues with 1,2-cyclohexanedione.	Arginine	12-20	lactotransferrin	Rattus norvegicus	33-44
1597458-13	1992	Arginine residues on lactoferrin thus appear to be essential for its specific recognition by parenchymal liver cells.	Arginine	0-8	lactotransferrin	Rattus norvegicus	21-32
1597458-14	1992	In particular the clustered N-terminal arginine residues, which resemble the arginine-rich receptor binding sequence in apoE, may be responsible for both the interaction of lactoferrin with its recognition site and the inhibition of the hepatic uptake of apoE-bearing lipoproteins.	Arginine	39-47	lactotransferrin	Rattus norvegicus	173-184
1353050-3	1992	The infusion of 10 nM somatostatin resulted in 40% inhibition of the secretion of both amylin and insulin induced by 11.1 mM glucose and 10 mM arginine, and this inhibition was significantly increased to 70% by the infusion of 100 nM somatostatin (p less than 0.05).	Arginine	143-151	islet amyloid polypeptide	Rattus norvegicus	87-93
1587525-1	1992	We have previously detected a single base substitution of G by A at the Arg codon CGC in exon 4 of the mutant lactate dehydrogenase (LDH) gene, an unstable LDH-B variant (case 1).	Arginine	72-75	lactate dehydrogenase B	Homo sapiens	156-161
1575702-2	1992	It was shown to possess endogenous argininosuccinate lyase activity catalysing the reversible cleavage of argininosuccinate to give fumarate and arginine with an equilibrium constant of 1.8 +/- 0.23 mM.	Arginine	145-153	delta-1 crystallin	Gallus gallus	35-58
1566916-3	1992	L-Arginine is thought to be the precursor of the endothelium-derived relaxing factor (EDRF) that mediates the response to ACh.	Arginine	0-10	alpha hemoglobin stabilizing protein	Homo sapiens	49-84
1566916-3	1992	L-Arginine is thought to be the precursor of the endothelium-derived relaxing factor (EDRF) that mediates the response to ACh.	Arginine	0-10	alpha hemoglobin stabilizing protein	Homo sapiens	86-90
1532572-8	1992	Both alpha v beta 6 and alpha v beta 5 are eluted from their respective immobilized ligands by a hexa-peptide containing the sequence Arg-Gly-Asp (RGD).	Arginine	134-137	adaptor related protein complex 5 subunit beta 1	Homo sapiens	32-38
1541678-1	1992	An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents.	Arginine	129-139	interleukin 1 alpha	Homo sapiens	48-61
1311955-3	1992	Similar to its ligands, the amino acid sequence of the activin receptor is highly conserved with only two conservative amino acid differences (Lys-39 and Val-92 in human versus Arg-39 and Ile-92 in the mouse).	Arginine	177-180	inhibin subunit beta E	Homo sapiens	55-62
1733935-0	1992	Critical functional requirement for the guanidinium group of the arginine 41 side chain of human epidermal growth factor as revealed by mutagenic inactivation and chemical reactivation.	Arginine	65-73	epidermal growth factor	Homo sapiens	97-120
1733935-1	1992	In a preliminary study we demonstrated that the formation of the epidermal growth factor (EGF) receptor-ligand complex requires the participation of the highly conserved arginine 41 side chain of the growth factor peptide (Engler, D.A., Montelione, G.T., and Niyogi, S.K.	Arginine	170-178	epidermal growth factor	Homo sapiens	65-88
1733935-1	1992	In a preliminary study we demonstrated that the formation of the epidermal growth factor (EGF) receptor-ligand complex requires the participation of the highly conserved arginine 41 side chain of the growth factor peptide (Engler, D.A., Montelione, G.T., and Niyogi, S.K.	Arginine	170-178	epidermal growth factor	Homo sapiens	90-93
1733935-12	1992	The results indicate that the chemical properties inherent in the guanidinium group of the arginine 41 side chain of hEGF are responsible for optimal receptor-ligand association.	Arginine	91-99	epidermal growth factor	Homo sapiens	117-121
1537377-0	1992	Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen.	Arginine	58-61	endoglin	Homo sapiens	45-53
1739745-9	1992	10% of calf apoA-I was shown to contain a propeptide, with the sequence Arg-His-Phe-Trp-Gln-Gln.	Arginine	72-75	APOAI	Bos taurus	12-18
1306524-9	1992	Single amino acid substitutions replacing Arg 201 with either Cys or His or Gln 227 with either Arg or Leu cause constitutive activation of adenylyl cyclase by inhibiting GTPase (gsp oncogene).	Arginine	42-45	GSM1	Homo sapiens	179-182
1399322-7	1992	EDRF has been identified as nitric oxide (NO) derived from the guanidino group of L-arginine.	Arginine	82-92	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
1729223-4	1992	In search of this negatively acting site, we discovered that CAR1 sensitivity to NCR derives from regulated inducer (arginine) exclusion.	Arginine	117-125	arginase	Saccharomyces cerevisiae S288C	61-65
1729223-6	1992	However, CAR1 expression in the presence of sufficient intracellular arginine is NCR insensitive.	Arginine	69-77	arginase	Saccharomyces cerevisiae S288C	9-13
1729616-11	1992	The ability of the ARG3 operator to act either as an operator or as an upstream activator sequence, depending on its location, and the functional organization of the anabolic and catabolic arginine genes suggest a simple model for arginine regulation in which an activator complex can turn into a repressor when able to interfere sterically with the process of transcription initiation.	Arginine	231-239	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	19-23
1284435-0	1992	Increased urinary excretion of urine protein 1 induced by L-arginine monohydrochloride.	Arginine	58-86	secretoglobin family 1A member 1	Homo sapiens	31-46
1492092-6	1992	Sequence comparison of different miniplasminogens showed that positions 49 (Arg), 83 (Arg) and 161 (Ser) in the light chain of the plasmin molecule may play a role in the interaction between plasminogen and streptokinase.	Arginine	76-79	plasminogen	Bos taurus	37-44
1492092-6	1992	Sequence comparison of different miniplasminogens showed that positions 49 (Arg), 83 (Arg) and 161 (Ser) in the light chain of the plasmin molecule may play a role in the interaction between plasminogen and streptokinase.	Arginine	86-89	plasminogen	Bos taurus	37-44
1656067-2	1991	The deduced primary translation product of the CAEV env gene consists of a 60- to 80-amino-acid signal peptide followed by an amino-terminal surface protein (SU) and a carboxy-terminal transmembrane protein (TM) separated by an Arg-Lys-Lys-Arg cleavage site.	Arginine	228-231	envelope polyprotein;trans-regulatory splicing-like protein	Caprine arthritis encephalitis virus	52-55
1656067-2	1991	The deduced primary translation product of the CAEV env gene consists of a 60- to 80-amino-acid signal peptide followed by an amino-terminal surface protein (SU) and a carboxy-terminal transmembrane protein (TM) separated by an Arg-Lys-Lys-Arg cleavage site.	Arginine	240-243	envelope polyprotein;trans-regulatory splicing-like protein	Caprine arthritis encephalitis virus	52-55
1807008-2	1991	GLP-1-related peptides were administered in a dosage of 400 pmol within 10 min into the pancreatic artery during glucose or arginine infusion and the changes in plasma insulin and glucagon in the pancreatic vein were studied.	Arginine	124-132	glucagon	Canis lupus familiaris	0-5
1656767-2	1991	Given that tumor necrosis factor-alpha (TNF-alpha) has been implicated as an important mediator in septic shock, we explored whether TNF-alpha enhances L-arginine-dependent synthesis of NO and L-citrulline in endothelial cells.	Arginine	152-162	tumor necrosis factor	Bos taurus	133-142
1930694-7	1991	This FSH-beta gene encodes a protein that differs from the published ovine protein sequence only at the carboxy terminus (Arg-109Glu-110[STOP codon] instead of Glu-109Arg-110[Glx-111]) and at positions 49 (Ala instead of Thr) and 88 (Arg instead of Ser).	Arginine	122-125	follitropin subunit beta	Bos taurus	5-13
25849507-2	2015	ARG plays important roles in cell morphogenesis, motility, growth and survival, and many of these biological roles overlap with the cellular functions of the ABL kinase.	Arginine	0-3	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	158-161
1915358-4	1991	In contrast to mammalian DHFR genes which span approximately 30 kb, the complete amino acid coding sequence of the mosquito DHFR gene spanned 614 nucleotides, including a single 56-nucleotide intron that interrupted a conserved Arg codon at amino acid position 27.	Arginine	228-231	dihydrofolate reductase	Homo sapiens	124-128
26097609-5	2015	The potential association of Arg/Trp+ Trp/Trp genotype of XRCC1 Arg194Trp with the risk of NSCLC is more evidence in smokers, and the OR (95% CI) was 1.78 (1.01-3.24).	Arginine	29-32	X-ray repair cross complementing 1	Homo sapiens	58-63
1720843-5	1991	The involvement of endothelium-derived relaxing factor (EDRF) in the effect of captopril was apparent from experiments with L-arginine, the precursor of EDRF, and L-NMMA, the "false" precursor of EDRF.	Arginine	124-134	alpha hemoglobin stabilizing protein	Homo sapiens	19-54
25953269-10	2015	), an inhibitor of argininosuccinate synthase, the rate-limiting enzyme for the recycling of l-citrulline to l-arginine, diminished the L-citrulline-induced retinal vasodilation.	Arginine	109-119	argininosuccinate synthase 1	Rattus norvegicus	19-45
1720843-5	1991	The involvement of endothelium-derived relaxing factor (EDRF) in the effect of captopril was apparent from experiments with L-arginine, the precursor of EDRF, and L-NMMA, the "false" precursor of EDRF.	Arginine	124-134	alpha hemoglobin stabilizing protein	Homo sapiens	56-60
1870212-3	1991	The second proteolytic event removes the carboxy-terminal arginine-rich sequence of P22 and converts it to the 16-kDa hepatitis B virus e antigen end product.	Arginine	58-66	calcineurin like EF-hand protein 1	Homo sapiens	84-87
25058375-3	2015	Involvement of the integrin was further shown by two disintegrins, Arg-Gly-Asp (RGD) and echistatin peptides, which occluded the effects of T3/T4 on viability, proliferating cell nuclear antigen (PCNA) (proliferation marker) and apoptotic gene expression.	Arginine	67-70	proliferating cell nuclear antigen	Mus musculus	160-194
25058375-3	2015	Involvement of the integrin was further shown by two disintegrins, Arg-Gly-Asp (RGD) and echistatin peptides, which occluded the effects of T3/T4 on viability, proliferating cell nuclear antigen (PCNA) (proliferation marker) and apoptotic gene expression.	Arginine	67-70	proliferating cell nuclear antigen	Mus musculus	196-200
1861080-10	1991	Sequencing of the C3b-like fragment purified by reverse phase chromatography indicates that initial cleavage of C3 by purified cathepsin G occurs at two positions in the amino-terminal part of the alpha-chain, at a Arg-Ser bond located between residues 748 and 749 and at a Leu-Asp bond between residues 751 and 752.	Arginine	215-218	cathepsin G	Homo sapiens	127-138
25686373-3	2015	Here we have unveiled a markedly different modification strategy in which a conserved arginine of EF-P is rhamnosylated by a glycosyltransferase (EarP) using dTDP-L-rhamnose as a substrate.	Arginine	86-94	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	158-162
25749046-6	2015	The underlying mechanism is complex, but increased DNA damage upon arginine deprivation due to decreased DNA repair proteins, FANCD2, ATM, and CHK1/2 most likely leads to increased apoptosis.	Arginine	67-75	FA complementation group D2	Homo sapiens	126-132
1657414-5	1991	Determination of the amino-terminal amino acids of the purified protein reveals that the mature CBS1 protein starts with Ile30, at the characteristic distance of +2 amino acids from an arginine residue (Arg28).	Arginine	185-193	Cbs1p	Saccharomyces cerevisiae S288C	96-100
2059221-8	1991	An interesting polymorphism, a Gln to Arg substitution, was detected in the carboxiterminal area of rat adducin 63.	Arginine	38-41	adducin 2	Rattus norvegicus	104-114
25585345-1	2015	Co-activator-associated arginine methyltransferase 1 (CARM1) asymmetrically di-methylates proteins on arginine residues.	Arginine	24-32	coactivator associated arginine methyltransferase 1	Homo sapiens	54-59
25636591-10	2015	KEY FINDINGS: 8-week l-arginine supplementation associated with physical training was effective in promoting greater tolerance to exercise that was accompanied by up-regulation of the protein expressions of mtTFA, PGC-1alpha, ATP synthase subunit c, COXIV, Cu/Zn-SOD and Mn-SOD.	Arginine	21-31	superoxide dismutase 2	Rattus norvegicus	271-277
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	245-248	H3 histone pseudogene 16	Homo sapiens	270-273
25737013-1	2015	The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues.	Arginine	50-58	protein arginine methyltransferase 1	Homo sapiens	79-86
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	245-248	H3 histone pseudogene 16	Homo sapiens	307-310
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	311-314	H3 histone pseudogene 16	Homo sapiens	270-273
2052624-7	1991	(iii) Identification of sequence regions, other than the effector loop and the nucleotide binding site, that may be involved in the functional cycle: they are loop L4, known to change conformation after GTP hydrolysis; helix alpha 2, especially Arg-73 and Met-67 in ras p21; loops L8 and L10, including ras p21 Arg-123, Lys-147, and Leu-120; and residues located spatially near the N and C termini.	Arginine	311-314	H3 histone pseudogene 16	Homo sapiens	307-310
26045834-4	2015	TT and CT+TT genotypes of XRCC1 194 (Arg&gt;Trp) were significantly associated with increased risk of TC, and CC and TC+CC genotypes of XRCC3 241 (Thr&gt;Met) revealed a significant associated with the TC risk.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	26-31
26045834-4	2015	TT and CT+TT genotypes of XRCC1 194 (Arg&gt;Trp) were significantly associated with increased risk of TC, and CC and TC+CC genotypes of XRCC3 241 (Thr&gt;Met) revealed a significant associated with the TC risk.	Arginine	37-40	X-ray repair cross complementing 3	Homo sapiens	136-141
26045834-5	2015	We only found that XRCC1 194 (Arg&gt;Trp) and XRCC3 241 (Thr&gt;Met) polymorphisms had interaction with smoking and drinking habits.	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	19-24
1903841-12	1991	The TIF51A gene was altered by site-directed mutagenesis at the site of hypusination by changing the Lys codon to that for Arg, thereby producing a stable protein that retains the positive charge but is not modified to the hypusine derivative.	Arginine	123-126	translation elongation factor eIF-5A	Saccharomyces cerevisiae S288C	4-10
1874272-1	1991	The endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) or a closely related nitrosothiol derivative, and is formed from the amino acid, L-arginine.	Arginine	149-159	alpha hemoglobin stabilizing protein	Homo sapiens	4-39
26045834-6	2015	In conclusion, the current study suggests that XRCC1 194 (Arg&gt;Trp) and XRCC3 241 (Thr&gt;Met) polymorphisms may be associated with TC risk in a Chinese population, especially in smokers and drinkers.	Arginine	58-61	X-ray repair cross complementing 1	Homo sapiens	47-52
1874272-1	1991	The endothelium-derived relaxing factor (EDRF) is nitric oxide (NO) or a closely related nitrosothiol derivative, and is formed from the amino acid, L-arginine.	Arginine	149-159	alpha hemoglobin stabilizing protein	Homo sapiens	41-45
27110035-5	2015	Through Western blot and mass spectrometry, the arginine/serine rich splicing factor Sfrs1 was identified as a galactose-selective endogenous lectin, overexpressed in B16F10 cells, compared with B16F1 cells.	Arginine	48-56	serine and arginine-rich splicing factor 1	Mus musculus	85-90
1870264-5	1991	Nucleotide sequencing of exon 6 of AT III gene showed a G to T transitional mutation resulting in the conversion of arginine-406 to methionine coexisted with normal allele which encodes arginine.	Arginine	116-124	serpin family C member 1	Homo sapiens	35-41
25416155-6	2015	Mutation of the Arg residues preceding the PKA phosphorylation site (Thr35) to Ala (R/A(30-33)) abolished I-1 phosphorylation and its binding to and inhibition of PP1c.	Arginine	16-19	protein phosphatase 1, regulatory (inhibitor) subunit 1A	Rattus norvegicus	106-109
25540195-3	2015	Arg has two distinct actin-binding domains and interacts physically and functionally with cortactin, an activator of the Arp2/3 complex.	Arginine	0-3	cortactin	Homo sapiens	90-99
25540195-7	2015	Arg stimulates formation of actin filament branches by Arp2/3 complex and cortactin.	Arginine	0-3	cortactin	Homo sapiens	74-83
2005902-5	1991	This result suggests that MCM1 could be an additional regulatory element of arginine metabolism.	Arginine	76-84	transcription factor MCM1	Saccharomyces cerevisiae S288C	26-30
25620702-5	2015	c-Abl/Arg regulates cellular proteasome abundance by controlling the PSMA7 subunit supply.	Arginine	6-9	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5
25468652-3	2015	A change in the codon 118 of the wild-type alpha-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p.(Arg118Cys) -, has been recurrently described in large FD screening studies of high-risk patients.	Arginine	79-87	galactosidase alpha	Homo sapiens	43-52
25359495-6	2015	Using site-directed mutagenesis, we showed that Asp 92, Glu 172, and Asp 282 of rat ApelinR are key residues in apelin binding by interacting with Lys 8, Arg 2, and Arg 4 of pE13F, respectively.	Arginine	154-157	apelin	Rattus norvegicus	112-118
25319540-9	2015	A molecular model of T-0632-occupied CCK1R was consistent with these experimental determinants, also identifying Met(121) in TM3 and Arg(336) in TM6 as important.	Arginine	133-136	cholecystokinin A receptor	Homo sapiens	37-42
25384976-7	2015	Mutant CDK12 proteins lacking their Arg-Ser-rich (RS) domain or just the RS domain alone acted as dominant negative proteins.	Arginine	36-39	cyclin dependent kinase 12	Homo sapiens	7-12
26284168-2	2015	A common genetic single nucleotide polymorphism (SNP) at codon 577 of the ACTN3 results in the replacement of an arginine (R) with a stop codon (X).	Arginine	113-121	actinin alpha 3	Homo sapiens	74-79
25416954-4	2014	The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation.	Arginine	188-196	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	138-165
25416954-4	2014	The plastid-localized PII signaling protein controls, in a glutamine-dependent manner, the key enzyme of the ornithine synthesis pathway, N-acetyl-l-glutamate kinase (NAGK), that leads to arginine and polyamine formation.	Arginine	188-196	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	167-171
25253735-2	2014	There is growing evidence that putrescine produced from arginine (Arg) and proline via ornithine decarboxylase is a key regulator of angiogenesis, embryogenesis, as well as placental and fetal growth.	Arginine	56-64	Ornithine decarboxylase 1	Drosophila melanogaster	87-110
25253735-2	2014	There is growing evidence that putrescine produced from arginine (Arg) and proline via ornithine decarboxylase is a key regulator of angiogenesis, embryogenesis, as well as placental and fetal growth.	Arginine	66-69	Ornithine decarboxylase 1	Drosophila melanogaster	87-110
25584213-14	2014	RESULTS: XRCC1 gene polymorphism is associated with increased risk of lung cancer when the Arg/Arg genotype was used as the reference group.	Arginine	95-98	X-ray repair cross complementing 1	Homo sapiens	9-14
25187541-6	2014	Rather, MNK catalytic activity enabled viral IRES-mediated translation/host cell cytotoxicity through negative regulation of the Ser/Arg (SR)-rich protein kinase (SRPK).	Arginine	133-136	ATPase copper transporting alpha	Homo sapiens	8-11
29082273-3	2014	The CAN1 gene encodes for an arginine permease that is responsible for the uptake of arginine and it can also transport the toxic analog of arginine, canavanine (Whelan et al., 1979).	Arginine	29-37	arginine permease CAN1	Saccharomyces cerevisiae S288C	4-8
2001376-8	1991	Features of this sequence which showed the greatest similarity to mammalian osteopontin included a region in which seven of nine consecutive residues are aspartic acid, a recognition sequence for integrin-mediated cell binding (-Arg-Gly-Asp), and four possible recognition sequences for phosphorylation by casein kinase II.	Arginine	229-232	secreted phosphoprotein 1	Homo sapiens	76-87
29082273-3	2014	The CAN1 gene encodes for an arginine permease that is responsible for the uptake of arginine and it can also transport the toxic analog of arginine, canavanine (Whelan et al., 1979).	Arginine	85-93	arginine permease CAN1	Saccharomyces cerevisiae S288C	4-8
29082273-4	2014	When CAN1 cells are grown on a media containing canavanine but lacking arginine, the cells die because of the uptake of the toxic canavanine.	Arginine	71-79	arginine permease CAN1	Saccharomyces cerevisiae S288C	5-9
1847138-2	1991	The chemical modification of histidine and arginine residues results in a loss of binding of the Mr 46,000 mannose 6-phosphate receptor (MPR 46) to a phosphomannan affinity matrix (Stein, M., Meyer, J. E., Hasilik, A., and von Figura, K. (1987) Biol.	Arginine	43-51	mannose-6-phosphate receptor, cation dependent	Homo sapiens	137-143
25073474-7	2014	L-Leucine and L-arginine competed with levodopa across the luminal enterocyte membrane as expected for b(0,+)AT-rBAT substrates, whereas dopa-decarboxylase and cathechol-O-methyl transferase inhibitors had no effect.	Arginine	14-24	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	112-116
25223783-2	2014	To further explore potentials of RNAi technology as therapeutics, we engineered and tested VEGFR2 siRNA molecules specifically targeted to tumors through covalently conjugated cyclo(Arg-Gly-Asp-d-Phe-Lys[PEG-MAL]) (cRGD) peptide, known to bind alphavbeta3 integrin receptors.	Arginine	182-185	kinase insert domain receptor	Homo sapiens	91-97
1847138-6	1991	The 5 histidine and 8 arginine residues within the luminal domain of MPR 46, which contains the ligand binding site, were exchanged by site-directed mutagenesis.	Arginine	22-30	mannose-6-phosphate receptor, cation dependent	Homo sapiens	69-75
1847138-9	1991	Nonconservative replacement of several arginine residues reduced binding activity and immunoreactivity, indicating that the loss of a positive charge at these positions alters the folding of MPR 46.	Arginine	39-47	mannose-6-phosphate receptor, cation dependent	Homo sapiens	191-197
1847138-10	1991	We conclude from these results that His-131 and Arg-137 are essential for binding of ligands by MPR 46.	Arginine	48-51	mannose-6-phosphate receptor, cation dependent	Homo sapiens	96-102
1671745-2	1991	It has been proposed that NH2OH is a putative intermediate in the biochemical pathway for the generation of nitric oxide (NO)/endothelium-derived relaxing factor (EDRF) from L-arginine.	Arginine	174-184	alpha hemoglobin stabilizing protein	Mus musculus	163-167
1991651-5	1991	The action of EDRF was abolished by oxyhemoglobin and methylene blue, and the generation of EDRF in response to shear stress was markedly inhibited or abolished by NG-nitro-L-arginine, by NG-amino-L-arginine, by calcium-free extracellular medium, and by depleting endothelial cells of endogenous L-arginine.	Arginine	173-183	alpha hemoglobin stabilizing protein	Homo sapiens	92-96
24888966-5	2014	TLR9-CTD exhibits one unique feature, a cluster of stacked aromatic and arginine side chains on its concave face.	Arginine	72-80	toll-like receptor 9	Mus musculus	0-4
1991651-6	1991	Addition of L-arginine to arginine-deficient but not arginine-containing endothelial cells rapidly restored the capacity of shear stress and bradykinin to generate EDRF.	Arginine	12-22	alpha hemoglobin stabilizing protein	Homo sapiens	164-168
1991651-6	1991	Addition of L-arginine to arginine-deficient but not arginine-containing endothelial cells rapidly restored the capacity of shear stress and bradykinin to generate EDRF.	Arginine	14-22	alpha hemoglobin stabilizing protein	Homo sapiens	164-168
25018058-10	2014	Our results suggest that the XRCC1 399 Gln/Gln and 194 Arg/Arg DNA repair genes play an important role in poor arsenic methylation capacity, thereby increasing the risk of UC in non-obvious arsenic exposure areas.	Arginine	59-62	X-ray repair cross complementing 1	Homo sapiens	29-34
1825118-1	1991	The lysine-rich sequence (-KKGGKKK-) located at the 50,000/20,000 Mr junction of myosin subfragment-1 (S-1) was cleaved by endoprotease Arg-C or by trypsin in the presence of ATP and an equimolar amount of actin.	Arginine	136-139	myosin heavy chain 14	Homo sapiens	81-87
25058871-5	2014	These overlapped metabolites show that decreased alanine asparate and glutamate metabolic pathway, arginine and proline metabolic pathway, and increased purine metabolism form a characteristic feature in response to IFN-alpha2b.	Arginine	99-107	interferon phi 1	Danio rerio	216-219
1681884-2	1991	In a concentration dependent fashion, LDLox antagonized the activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor (EDRF), which was produced in vitro by incubation of a partially purified EDRF-forming enzyme in the presence of L-arginine, Ca2+ and NADPH.	Arginine	261-271	alpha hemoglobin stabilizing protein	Homo sapiens	112-147
24793417-7	2014	The activation of these pathways takes advantage of the increased availability of arginine due to a decreased system y(+)l-mediated efflux, likely ascribable to a reduced expression of Slc7a6 transporter.	Arginine	82-90	solute carrier family 7 member 6	Homo sapiens	185-191
1681884-2	1991	In a concentration dependent fashion, LDLox antagonized the activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor (EDRF), which was produced in vitro by incubation of a partially purified EDRF-forming enzyme in the presence of L-arginine, Ca2+ and NADPH.	Arginine	261-271	alpha hemoglobin stabilizing protein	Homo sapiens	149-153
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	23-31	gastrin	Homo sapiens	50-57
24907905-2	2014	Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity.	Arginine	175-183	glial fibrillary acidic protein	Homo sapiens	78-109
24907905-2	2014	Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity.	Arginine	175-183	glial fibrillary acidic protein	Homo sapiens	111-115
25101906-4	2014	Here, sequence analysis of CDX2 mRNA from colonic mucosa-derived tissues revealed an alternatively spliced transcript (CDX2/AS) that encodes a protein with a truncated homeodomain and a novel carboxy-terminal domain enriched in serine and arginine residues (RS domain).	Arginine	239-247	caudal type homeobox 2	Homo sapiens	27-31
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	23-31	gastrin	Homo sapiens	112-125
25101906-4	2014	Here, sequence analysis of CDX2 mRNA from colonic mucosa-derived tissues revealed an alternatively spliced transcript (CDX2/AS) that encodes a protein with a truncated homeodomain and a novel carboxy-terminal domain enriched in serine and arginine residues (RS domain).	Arginine	239-247	caudal type homeobox 2	Homo sapiens	119-126
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	23-31	gastrin	Homo sapiens	183-196
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	159-168	gastrin	Homo sapiens	50-57
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	159-168	gastrin	Homo sapiens	112-125
24904080-2	2014	Argininosuccinate lyase (ASL) is the only enzyme in mammals that is capable of synthesizing arginine.	Arginine	92-100	argininosuccinate lyase	Mus musculus	0-23
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	159-168	gastrin	Homo sapiens	183-196
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	249-252	gastrin	Homo sapiens	50-57
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	285-288	gastrin	Homo sapiens	50-57
1773057-4	1991	We found that pairs of arginine residues flanking gastrin 34, the typical processing site sequence of all other preprogastrins and many peptide hormones, were arginines in the bovine preprogastrin, but the first basic amino acid pair had changed to Arg-Trp (57-58 residues) instead of Arg-Arg in the feline preprogastrin.	Arginine	285-288	gastrin	Homo sapiens	50-57
2046858-5	1991	Carboxypeptidase E activity is stimulated in vitro by cobalt ion and removes the Lys and Arg residues with equal facility.	Arginine	89-92	carboxypeptidase E	Homo sapiens	0-18
1926867-3	1991	There is strong evidence that the major endothelium-derived relaxing factor (EDRF) is the free radical nitric oxide (NO) formed enzymatically from L-arginine.	Arginine	147-157	alpha hemoglobin stabilizing protein	Homo sapiens	40-75
24962580-6	2014	However, addition of two PAM residues (Arg(126)-His(127)) to the COOH terminus of VEK30 (VEK32) maintained a monomeric peptidic structure, but exhibited similar K2hPg binding affinity as full-length dimeric PAM.	Arginine	39-42	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	25-28
24962580-7	2014	We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold.	Arginine	37-40	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	114-117
1926867-3	1991	There is strong evidence that the major endothelium-derived relaxing factor (EDRF) is the free radical nitric oxide (NO) formed enzymatically from L-arginine.	Arginine	147-157	alpha hemoglobin stabilizing protein	Homo sapiens	77-81
24962580-7	2014	We identified five residues in a1a2 (Arg(113), His(114), Glu(116), Arg(126), His(127)), mutation of which reduced PAM binding affinity for K2hPg by ~ 1000-fold.	Arginine	67-70	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	114-117
2260635-10	1990	The results of these experiments show that attachment and spreading of bovine aortic endothelial and smooth muscle cells depend primarily on the presence of the Arg-Gly-Asp-Ser (RGDS) sequence in the recombinant fibronectin proteins.	Arginine	161-164	fibronectin 1	Bos taurus	212-223
25606432-4	2014	L23a is highly basic, containing a combined 45 Arg, Lys, and His residues and only 14 Asp and Glu residues.	Arginine	47-50	ribosomal protein L23a	Homo sapiens	0-4
1979590-0	1990	Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.	Arginine	108-118	tumor necrosis factor	Bos taurus	0-27
24828610-4	2014	Metabolic labeling experiments reveal a clear defect in the kinetics of insulin biosynthesis in islets from PC1/3(N222D) mutant mice, resulting in an increase in both proinsulin and its processing intermediates, predominantly lacking cleavage at the Arg-Arg site.	Arginine	250-253	proprotein convertase subtilisin/kexin type 1	Mus musculus	108-113
24828610-4	2014	Metabolic labeling experiments reveal a clear defect in the kinetics of insulin biosynthesis in islets from PC1/3(N222D) mutant mice, resulting in an increase in both proinsulin and its processing intermediates, predominantly lacking cleavage at the Arg-Arg site.	Arginine	254-257	proprotein convertase subtilisin/kexin type 1	Mus musculus	108-113
1979590-11	1990	TNF-alpha-induced L-arginine-dependent increases in cGMP were also evident in bovine renal artery vascular smooth muscle cells, COS-1 cells, and 1502 human fibroblasts.	Arginine	18-28	tumor necrosis factor	Bos taurus	0-9
1979590-12	1990	These findings suggest that TNF-alpha induces expression in mesangial cell of an enzyme(s) involved in the formation of L-arginine-derived NO.	Arginine	120-130	tumor necrosis factor	Bos taurus	28-37
24860166-6	2014	Brd4 PID shows a surprising sequence motif similarity to the trans-activating Tat protein from HIV-1, which includes a core RxL motif, a polybasic cluster known as arginine-rich motif, and a C-terminal leucine motif.	Arginine	164-172	Tat	Human immunodeficiency virus 1	78-81
2146491-0	1990	The degradation sequence of adenovirus E1A consists of the amino-terminal tetrapeptide Met-Arg-His-Ile.	Arginine	91-94	macrophage stimulating 1 S homeolog	Xenopus laevis	39-42
24802752-8	2014	Using molecular modeling, we hypothesized that Arg(28) might contribute to IL-6R/CNTFR plasticity of CNTF.	Arginine	47-50	ciliary neurotrophic factor	Homo sapiens	81-85
24793772-9	2014	Altered protein arginine methylation is also observed when cells are treated with the GABAA agonist muscimol but not an antagonist, bicuculline.	Arginine	16-24	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	86-91
2146491-8	1990	In this study, we have used Xenopus laevis oocytes injected with mRNAs encoding altered E1A proteins to show that the amino-terminal tetrapeptide Met-Arg-His-Ile is required for E1A degradation.	Arginine	150-153	macrophage stimulating 1 S homeolog	Xenopus laevis	88-91
2146491-8	1990	In this study, we have used Xenopus laevis oocytes injected with mRNAs encoding altered E1A proteins to show that the amino-terminal tetrapeptide Met-Arg-His-Ile is required for E1A degradation.	Arginine	150-153	macrophage stimulating 1 S homeolog	Xenopus laevis	178-181
2172006-2	1990	Site-directed mutagenesis was employed to examine the function of two highly conserved residues, Tyr-37 and Arg-41, of human EGF (hEGF) in receptor binding.	Arginine	108-111	epidermal growth factor	Homo sapiens	125-128
24819655-5	2014	On the other hand, in the presence of L-histidine or L-arginine, [Eu(pda)2](-) exhibited intense CPL (glum ~ 0.08 for the (5)D0   (7)F1 transition at 0.10 mol dm(-3) of the amino acid), whereas quite weak CPL was observed for [Eu(bda)2](-) under the same conditions (glum &lt; 0.01).	Arginine	53-63	hephaestin	Homo sapiens	97-100
2172006-2	1990	Site-directed mutagenesis was employed to examine the function of two highly conserved residues, Tyr-37 and Arg-41, of human EGF (hEGF) in receptor binding.	Arginine	108-111	epidermal growth factor	Homo sapiens	130-134
24727527-2	2014	Results revealed that (a) a positively charged amino acid, lysine (K) or arginine (R), in TBP can anchor ferritin to negative zeta-potential substrates, (b) the adsorption force of K is stronger than R, and (c) local electrostatic interactions and flexibility of TBP directly affect adsorption.	Arginine	73-81	TATA-box binding protein	Homo sapiens	90-93
24727527-2	2014	Results revealed that (a) a positively charged amino acid, lysine (K) or arginine (R), in TBP can anchor ferritin to negative zeta-potential substrates, (b) the adsorption force of K is stronger than R, and (c) local electrostatic interactions and flexibility of TBP directly affect adsorption.	Arginine	73-81	TATA-box binding protein	Homo sapiens	263-266
2168884-1	1990	Two gastrin analogs containing a D- and a L-tetrafluorinated tyrosyl residue (Arg-Arg-Leu-Glu-Glu-Glu-Glu-Glu-Ala-(F4)Tyr-Gly) were synthesized and tested as substrates and inhibitors of the insulin receptor kinase.	Arginine	78-81	gastrin	Homo sapiens	4-11
2232482-6	1990	The pH optimum for cathepsin B (substrate: Z-Arg-Arg-HNMec) and L (substrate: Z-Phe-Arg-HNMec in the presence of Z-Phe-Phe-CHN2) was approximately pH 6.0 for both glomeruli and renal cortex; while that for cathepsin H (substrate: Arg-HNMec) was approximately 6.5.	Arginine	49-52	cathepsin B	Rattus norvegicus	19-30
2223769-2	1990	The residues at Lys 344 and Arg 72 were previously suggested as salt bridge contacts in the cytochrome b5-cytochrome P-450cam association complex and implicated in the physiological putidaredoxin-cytochrome P-450cam complex [Stayton, P. S., Poulos, T. L., &amp; Sligar, S. G. (1989) Biochemistry 28, 8201-8205].	Arginine	28-31	cytochrome b5 type A	Homo sapiens	92-105
24737319-7	2014	Interestingly, Nav1.2 in the seizure samples contained methylated arginine (MeArg) at three sites.	Arginine	66-74	sodium voltage-gated channel alpha subunit 2	Homo sapiens	15-21
1973165-3	1990	These results indicate that the amino acid sequence Arg-Glu-His at positions 246-248 of S-II is important for its stimulatory activity.	Arginine	52-55	transcription elongation factor A1	Homo sapiens	88-92
2370855-3	1990	The synthesis of this substance could be stimulated with the receptor agonist neurotensin (10 microM) or by addition of the EDRF/NO substrate L-arginine (100 microM).	Arginine	142-152	alpha hemoglobin stabilizing protein	Mus musculus	124-128
25927994-1	2014	In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues.	Arginine	240-248	coactivator associated arginine methyltransferase 1	Homo sapiens	88-93
25927994-1	2014	In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues.	Arginine	240-248	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	132-138
24831947-9	2014	Experiments with simulated data indicate that ARGweaver converges rapidly to the posterior distribution over ARGs and is effective in recovering various features of the ARG for dozens of sequences generated under realistic parameters for human populations.	Arginine	46-49	serpin family A member 2 (gene/pseudogene)	Homo sapiens	109-113
2370855-4	1990	In Ca2(+)-free Locke"s solution, stimulation of EDRF/NO production by both neurotensin and L-arginine was abolished.	Arginine	91-101	alpha hemoglobin stabilizing protein	Mus musculus	48-52
2370855-7	1990	L-Arginine and NADPH were required for maximal synthesis of EDRF/NO by the enzyme(s).	Arginine	0-10	alpha hemoglobin stabilizing protein	Mus musculus	60-64
2158989-9	1990	Two pairs of resonances are found to have similar relaxation properties and/or dipolar as similarly shifted resonances that arise from a distal His and Arg in horseradish peroxidase (as also found in LPO-CN), and suggest that MPO also possesses these catalytically functional residues in the distal heme pocket.	Arginine	152-155	lactoperoxidase	Bos taurus	200-203
24842991-1	2014	The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm.	Arginine	21-29	serine and arginine rich splicing factor 1	Homo sapiens	48-53
24842991-1	2014	The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm.	Arginine	21-29	serine and arginine rich splicing factor 1	Homo sapiens	75-78
24842991-1	2014	The shuttling Serine/Arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm.	Arginine	21-29	serine and arginine rich splicing factor 1	Homo sapiens	79-82
2158989-9	1990	Two pairs of resonances are found to have similar relaxation properties and/or dipolar as similarly shifted resonances that arise from a distal His and Arg in horseradish peroxidase (as also found in LPO-CN), and suggest that MPO also possesses these catalytically functional residues in the distal heme pocket.	Arginine	152-155	myeloperoxidase	Bos taurus	226-229
2138623-1	1990	The synthetic heptapeptide, Ile-Arg-Ile-Cys-Arg-Lsy-Gly-ethoxy, an analog of one of the actin binding sites on myosin head (S-site) (Suzuki, R., Nishi, N., Tokura, S., and Morita, F. (1987) J. Biol.	Arginine	32-35	myosin heavy chain 14	Homo sapiens	111-117
24569881-7	2014	We show that PKA-dependent phosphorylation of the C-terminus of Kir6.2 decreases binding to COPI and, thereby, silences the arginine-based retrieval signal.	Arginine	124-132	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	64-70
1689609-2	1990	We have made a mutein of human G-CSF, KW-2228, in which Thr-1, Leu-3, Gly-4, Pro-5, and Cys-17 were respectively substituted with Ala, Thr, Tyr, Arg, and Ser; showed more potent G-CSF activity; and retained full biological activity and receptor binding capacity at least 2 weeks of radioiodination.	Arginine	145-148	colony stimulating factor 3	Homo sapiens	31-36
24705350-1	2014	This work is based on previous evidence showing that chemotactic sequence of the urokinase receptor (uPAR(88-92)) drives angiogenesis in vitro and in vivo in a protease-independent manner, and that the peptide Ac-Arg-Glu-Arg-Phe-NH(2) (RERF) prevents both uPAR(88-92)- and VEGF-induced angiogenesis.	Arginine	213-216	vascular endothelial growth factor A	Mus musculus	273-277
2155667-6	1990	Addition of two extra N-terminal arginine residues to RRASpVA increased PP2A catalysed dephosphorylation 4- to 5-fold, without altering dephosphorylation by PP2C.	Arginine	33-41	protein phosphatase 2 phosphatase activator	Homo sapiens	72-76
24850148-1	2014	Peptidylarginine deiminase type 2 (PADI2) deiminates (or citrullinates) arginine residues in protein to citrulline residues in a Ca2+-dependent manner, and is found in lymphocytes and macrophages.	Arginine	8-16	peptidyl arginine deiminase 2	Homo sapiens	35-40
2108716-1	1990	We have studied the intracellular modifications of human apoAII by pulse-chase labeling of HepG2 cell cultures with [35S]methionine or [3H]arginine followed by two-dimensional analysis and autoradiography of the radiolabeled apoAII isoproteins.	Arginine	139-147	apolipoprotein A2	Homo sapiens	57-63
25191616-8	2014	A parenteral bolus of glucose or arginine increased insulin and ghrelin concentrations in cats.	Arginine	33-41	ghrelin and obestatin prepropeptide	Felis catus	64-71
24567323-6	2014	Chromatin immunoprecipitation analyses show that yku70 mutants with these lysines replaced by arginines exhibit reduced Ku-DNA association at both telomeres and internal DNA breaks.	Arginine	94-103	ATP-dependent DNA helicase YKU70	Saccharomyces cerevisiae S288C	49-54
2340183-3	1990	Cleavage of the chicken TGF-beta 2 precursor at a pentabasic Arg-Arg-Lys-Lys-Arg site would produce a 112-amino acid processed peptide differing by only one amino acid from the human TGF-beta 2 peptide.	Arginine	61-64	transforming growth factor beta 2	Gallus gallus	24-34
2340183-3	1990	Cleavage of the chicken TGF-beta 2 precursor at a pentabasic Arg-Arg-Lys-Lys-Arg site would produce a 112-amino acid processed peptide differing by only one amino acid from the human TGF-beta 2 peptide.	Arginine	65-68	transforming growth factor beta 2	Gallus gallus	24-34
24700861-4	2014	SRP68-RBD is a tetratricopeptide-like module that binds to a RNA three-way junction, bends the RNA, and inserts an alpha-helical arginine-rich motif (ARM) into the major groove.	Arginine	129-137	signal recognition particle 68	Homo sapiens	0-5
24651445-6	2014	In vitro kinase assays demonstrated that arginine supplementation activated ERK1/2, Akt, PKA and its downstream target, cAMP response element binding protein (CREB).	Arginine	41-49	cAMP responsive element binding protein 1	Homo sapiens	120-157
2244960-5	1990	Polymerase chain reaction and oligonucleotide hybridization were used to demonstrate that five of seven transformed lung cell lines contain codon 61 Ki-ras-activating mutations, resulting in an arginine substitution for wild-type glutamine.	Arginine	194-202	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	149-155
24651445-6	2014	In vitro kinase assays demonstrated that arginine supplementation activated ERK1/2, Akt, PKA and its downstream target, cAMP response element binding protein (CREB).	Arginine	41-49	cAMP responsive element binding protein 1	Homo sapiens	159-163
33813270-3	2021	In our study, we show that a short 12-residue solubility enhancing peptide (SEP) tag containing nine arginines (C9R) attached at the C-terminus of EGFR-ECDIII reduces the inclusion body formation and increases the final yield by six times (20 mg/L).	Arginine	101-110	epidermal growth factor receptor	Mus musculus	147-151
24589551-0	2014	Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.	Arginine	45-53	spindlin 1	Homo sapiens	85-89
24589551-0	2014	Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.	Arginine	45-53	spindlin 1	Homo sapiens	106-115
33821889-8	2021	Based on spectroscopic, kinetic, and electrochemical studies, we deduce that DOPA residue, when present within the distal pocket of mutant Mb, alone serves the role of His/Arg-pair of peroxidases.	Arginine	172-175	myoglobin	Homo sapiens	139-141
24589551-8	2014	Taken together, our work connects a histone "lysine-arginine" methylation pattern readout by Spindlin1-to-Wnt signaling at the transcriptional level.	Arginine	52-60	spindlin 1	Homo sapiens	93-102
24448798-3	2014	For instance, the general amino acid permease Gap1 transports all amino acids, whereas Can1 and Lyp1 catalyze specific uptake of arginine and lysine, respectively.	Arginine	129-137	arginine permease CAN1	Saccharomyces cerevisiae S288C	87-91
24448798-9	2014	Measurements of the kinetic parameters of arginine and lysine uptake by the wild-type and mutant Can1 permeases, together with docking calculations for each amino acid in their binding site, suggest a model in which residues at positions 176 and 456 confer substrate selectivity at the ligand-binding stage and/or in the course of conformational changes required for transport.	Arginine	42-50	arginine permease CAN1	Saccharomyces cerevisiae S288C	97-101
33820827-6	2021	The inhibitor structure and its putative model show that the P1-Arg inserts into the S1 pocket, whereas the P2-Lys and P4-Arg interacts with the Asp/Glu-rich 99-loop that is unique to MSPL.	Arginine	64-67	transmembrane serine protease 13	Homo sapiens	184-188
24480307-4	2014	The 5-LOX structure suggested association between Arg(101) in the beta-sandwich and Asp(166) in the catalytic domain, due to electrostatic interaction as well as hydrogen bonds.	Arginine	50-53	lysyl oxidase	Homo sapiens	6-9
33820827-6	2021	The inhibitor structure and its putative model show that the P1-Arg inserts into the S1 pocket, whereas the P2-Lys and P4-Arg interacts with the Asp/Glu-rich 99-loop that is unique to MSPL.	Arginine	122-125	transmembrane serine protease 13	Homo sapiens	184-188
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	TNF receptor associated factor 6	Homo sapiens	38-43
24505477-6	2014	Dietary arginine or glutamine supplementation had significant (P&lt;0.05) influence on the clinical and biochemical parameters (T-SOD, IL-17 and TNF-alpha) in colitis model.	Arginine	8-16	interleukin 17A	Homo sapiens	135-140
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	formyl peptide receptor 2	Homo sapiens	108-112
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	formyl peptide receptor 2	Homo sapiens	189-193
9354668-11	1997	A single cysteine to arginine substitution (Cys759Arg) in this region resulted in high basal levels of constitutive JAK3 tyrosine phosphorylation unresponsive to either downregulation by serum starvation or cytokine-mediated upregulation.	Arginine	21-29	Janus kinase 3	Homo sapiens	116-120
24284797-6	2014	SRSF3-TR lacked two-thirds of the Arg/Ser-rich (RS) domain whose phosphorylation state is known to be crucial for subcellular distribution.	Arginine	34-37	serine and arginine rich splicing factor 3	Homo sapiens	0-5
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Arginine	108-116	leucine-rich PPR-motif containing	Mus musculus	74-80
24430182-5	2014	Using mass spectrometry, we identified SIRT3-regulated lysine residues in LRP130 that generated a lysine-to-arginine (KR) mutant of LRP130 that mimics deacetylated protein.	Arginine	108-116	leucine-rich PPR-motif containing	Mus musculus	132-138
34893304-1	2022	In this paper, a novel arginine-glucose derived carbonaceous-material-loaded SiO2 composite catalyst (Ar-G-CM/SiO2) was synthesized from non-toxic and harmless reagents (arginine, glucose and tetraethylorthosilicate) by simple hydrothermal process.	Arginine	170-178	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	102-106
24434208-6	2014	Collectively, our studies uncover a mechanism by which BAF155 acquires tumorigenic functions via arginine methylation.	Arginine	97-105	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	55-61
34609723-10	2022	Through CMap, we finally identified 14 candidate drugs for the ARG high risk population.	Arginine	63-66	cystatin F	Homo sapiens	8-12
24275664-3	2014	Sequence comparison of the juxtamembrane region identified similar palindromic sequences in human CD163 ((1044)Arg-Ser-Ser-Arg) and proTNF-alpha ((78)Arg-Ser-Ser-Ser-Arg).	Arginine	111-114	CD163 molecule	Homo sapiens	98-103
24275664-3	2014	Sequence comparison of the juxtamembrane region identified similar palindromic sequences in human CD163 ((1044)Arg-Ser-Ser-Arg) and proTNF-alpha ((78)Arg-Ser-Ser-Ser-Arg).	Arginine	123-126	CD163 molecule	Homo sapiens	98-103
24275664-3	2014	Sequence comparison of the juxtamembrane region identified similar palindromic sequences in human CD163 ((1044)Arg-Ser-Ser-Arg) and proTNF-alpha ((78)Arg-Ser-Ser-Ser-Arg).	Arginine	123-126	CD163 molecule	Homo sapiens	98-103
24275664-7	2014	Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of knock-in of the Arg-Ser-Ser-Arg sequence in mouse CD163 revealed a receptor shedding comparable with that of human CD163.	Arginine	108-111	CD163 molecule	Homo sapiens	142-147
22339171-3	2014	In our previous paper we showed that the MMP-9 enzyme recognizes a specific peptide sequence, Lys-Gly- Pro-Arg-Ser-Leu-Ser-Gly-Lys, and cleaves the peptide into two parts [1].	Arginine	107-110	matrix metallopeptidase 9	Homo sapiens	41-46
34643933-0	2022	The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2.	Arginine	36-39	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	131-136
34992424-7	2021	Relative asymmetric arginine dimethylation levels of HNRNPA3 proteins in human pancreatic tissues were detected by the immunoprecipitation combined with Western blot.	Arginine	20-28	heterogeneous nuclear ribonucleoprotein A3	Homo sapiens	53-60
34992539-9	2021	We also show that the naturally occurring arginine in NaV1.3 (NaV1.3-R1560), which corresponds to NaV1.7-W1538R, is not sufficient to explain the resistance of NaV1.3 to clinically-relevant concentrations of lacosamide.	Arginine	42-50	sodium voltage-gated channel alpha subunit 3	Homo sapiens	62-74
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Arginine	26-29	3-oxo-5-alpha-steroid 4-dehydrogenase family protein	Arabidopsis thaliana	161-164
24060357-7	2014	For the Q576R of IL4R, Th1/Th2 ratio was significantly lower for the homozygous SNP (Arg/Arg) compared to the WT (Gln/Gln) (p = 0.035).	Arginine	85-88	interleukin 4 receptor	Homo sapiens	17-21
24060357-7	2014	For the Q576R of IL4R, Th1/Th2 ratio was significantly lower for the homozygous SNP (Arg/Arg) compared to the WT (Gln/Gln) (p = 0.035).	Arginine	85-88	negative elongation factor complex member C/D	Homo sapiens	23-26
24060357-7	2014	For the Q576R of IL4R, Th1/Th2 ratio was significantly lower for the homozygous SNP (Arg/Arg) compared to the WT (Gln/Gln) (p = 0.035).	Arginine	89-92	interleukin 4 receptor	Homo sapiens	17-21
24060357-7	2014	For the Q576R of IL4R, Th1/Th2 ratio was significantly lower for the homozygous SNP (Arg/Arg) compared to the WT (Gln/Gln) (p = 0.035).	Arginine	89-92	negative elongation factor complex member C/D	Homo sapiens	23-26
34916780-14	2021	Conclusion: Knockdown of TRIM8 can alleviate H/R-induced oxidative stress by triggering the PI3K/AKT pathway, thus attenuating pyropyosis and apoptosis in vitro.	Arginine	47-48	tripartite motif containing 8	Homo sapiens	25-30
24268404-4	2014	These proteases cleave OPN at several positions near the integrin-binding sequence Arg-Gly-Asp(138).	Arginine	83-86	secreted phosphoprotein 1	Bos taurus	23-26
34943060-0	2021	l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.	Arginine	0-10	sirtuin 1	Mus musculus	80-85
24552712-6	2014	Decreased T cell receptor (TCR) zeta expression on CD8(+) T cells was significantly associated with an increased frequency of MDSCs in treatment-naive CHC patients and was restored by L-arginine treatment in vitro.	Arginine	184-194	CD8a molecule	Homo sapiens	51-54
34943060-0	2021	l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.	Arginine	0-10	sirtuin 1	Mus musculus	99-104
34943060-7	2021	In addition, l-Arg exposure dramatically increased the mRNA and protein expressions of SIRT1.	Arginine	13-18	sirtuin 1	Mus musculus	87-92
34943060-8	2021	The cytoprotective effect of l-Arg was restricted by the SIRT1 inhibitor EX527, which led to an increase in ROS level, apoptosis rate, and decreased cell MMP.	Arginine	29-34	sirtuin 1	Mus musculus	57-62
34943060-10	2021	Our findings revealed that l-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.	Arginine	27-32	sirtuin 1	Mus musculus	117-122
23990457-8	2014	The overall data indicated a significant association of XRCC1 Arg399Gln polymorphism with leukemia risk (Gln/Gln versus Arg/Arg: OR = 1.37, 95% confidence interval (CI) = 1.08-1.74; dominant model: OR = 1.23, 95%CI = 1.03-1.46; recessive model: OR = 1.23, 95%CI = 1.06-1.44).	Arginine	62-65	X-ray repair cross complementing 1	Homo sapiens	56-61
23990457-8	2014	The overall data indicated a significant association of XRCC1 Arg399Gln polymorphism with leukemia risk (Gln/Gln versus Arg/Arg: OR = 1.37, 95% confidence interval (CI) = 1.08-1.74; dominant model: OR = 1.23, 95%CI = 1.03-1.46; recessive model: OR = 1.23, 95%CI = 1.06-1.44).	Arginine	120-123	X-ray repair cross complementing 1	Homo sapiens	56-61
34944251-3	2021	Skeletal muscle from piglets born from sows from ARG group had greater mRNA expression of MYOD (p = 0.043) and MYOG (p <= 0.01), and tended to present greater mRNA expression (p = 0.06) of IGF-2 gene compared to those born from CON sows.	Arginine	49-52	insulin like growth factor 2	Homo sapiens	189-194
34937540-4	2021	Cox12 with arginine 17 residue substituted by histidine (R17H) or cysteine (R17C) (mutations analogous to those observed in human patients) failed to complement the loss of Cox12 function.	Arginine	11-19	cytochrome c oxidase subunit VIb	Saccharomyces cerevisiae S288C	0-5
24247247-0	2013	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.	Arginine	18-26	protein arginine methyltransferase 7	Homo sapiens	48-53
24247247-0	2013	Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.	Arginine	18-26	retinoid X receptor alpha	Homo sapiens	76-79
24247247-6	2013	Analysis of the specific methylation sites within intact histone H2B and within H2B and H4 peptides revealed novel post-translational modification sites and a unique specificity of PRMT7 for methylating arginine residues in lysine- and arginine-rich regions.	Arginine	203-211	protein arginine methyltransferase 7	Homo sapiens	181-186
24247247-6	2013	Analysis of the specific methylation sites within intact histone H2B and within H2B and H4 peptides revealed novel post-translational modification sites and a unique specificity of PRMT7 for methylating arginine residues in lysine- and arginine-rich regions.	Arginine	236-244	protein arginine methyltransferase 7	Homo sapiens	181-186
34517782-5	2021	Besides, miR-148 improved the immune dysfunction induced by MI/R through increasing the number of interleukin (IL)-10+ cells and reducing the number of inducible nitric oxide synthase (iNOS)+ cells.	Arginine	63-64	interleukin 10	Rattus norvegicus	98-117
24247247-7	2013	We demonstrate that a prominent substrate recognition motif consists of a pair of arginine residues separated by one residue (RXR motif).	Arginine	82-90	retinoid X receptor alpha	Homo sapiens	126-129
24376578-10	2013	In the MDM2 SNP309-TP53 R72P interaction analysis, we found that subjects with MDM2 309TT and TP53 Pro/Pro genotype, MDM2 309 TG and TP53 Arg/Pro genotype, and MDM2 309 GG and TP53 Pro/Pro genotype were associated with significantly increased risk of developing HCC as compared with the reference MDM2 309TT and TP53 Arg/Arg genotype.	Arginine	138-141	MDM2 proto-oncogene	Homo sapiens	7-11
34517782-6	2021	In addition, miR-148 relieved the apoptosis of cardiomyocytes induced by MI/R through inhibiting the expression of Bax and elevating the expression of Bcl-2.	Arginine	76-77	BCL2 associated X, apoptosis regulator	Rattus norvegicus	115-118
34607003-4	2021	METHODS: Differentially expressed miRNAs were provided by Gene Expression Omnibus (GEO) datasets and RT-qPCR examined RNA levels of miR-106a-5p and Jumonji domain-containing protein 6 (JMJD6), an enzyme causing lysine hydroxylation and arginine demethylation.	Arginine	236-244	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	148-183
24349317-4	2013	We predicted a novel molecular model for ECP binding of heparin hexasaccharide (Hep6), [GlcNS(6S)-IdoA(2S)]3, and residues Gln(40), His(64) and Arg(105) were indicated as major contributions for the interaction.	Arginine	144-147	ribonuclease A family member 3	Homo sapiens	41-44
24349250-7	2013	We demonstrate that this difference in calmodulin binding was due to the unique cysteine residue in the KCNQ2 subunit at aa 527 in Helix B, which corresponds to an arginine residue in other KCNQ subunits including KCNQ3.	Arginine	164-172	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	104-109
34607003-4	2021	METHODS: Differentially expressed miRNAs were provided by Gene Expression Omnibus (GEO) datasets and RT-qPCR examined RNA levels of miR-106a-5p and Jumonji domain-containing protein 6 (JMJD6), an enzyme causing lysine hydroxylation and arginine demethylation.	Arginine	236-244	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	185-190
34805153-4	2021	Among them, a single mutation on the retinol saturase gene (RETSAT) containing amino acid switch from glutamine (Q) to arginine (R) at the position 247 was identified.	Arginine	119-127	retinol saturase	Homo sapiens	60-66
34769369-1	2021	Competition for the amino acid arginine by endothelial nitric-oxide synthase (NOS3) and (pro-)inflammatory NO-synthase (NOS2) during endotoxemia appears essential in the derangement of the microcirculatory flow.	Arginine	31-39	nitric oxide synthase 3, endothelial cell	Mus musculus	43-76
24042460-5	2013	Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus.	Arginine	103-111	uncharacterized protein LOC700391	Macaca mulatta	0-6
34769369-1	2021	Competition for the amino acid arginine by endothelial nitric-oxide synthase (NOS3) and (pro-)inflammatory NO-synthase (NOS2) during endotoxemia appears essential in the derangement of the microcirculatory flow.	Arginine	31-39	nitric oxide synthase 3, endothelial cell	Mus musculus	78-82
24121506-5	2013	Within L1C domains, five amino acid residues (Leu-135, Gly-188, Arg-244, and vicinal His-318 and Lys-319) were identified as IRR-specific by species conservation analysis of the IR family.	Arginine	64-67	insulin receptor related receptor	Homo sapiens	125-128
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	diacylglycerol O-acyltransferase 1	Homo sapiens	51-56
34433661-2	2021	Acute myeloid leukemia (AML) downregulates the expression of argininosuccinate synthase (ASS1), a recognized rate-limiting enzyme for arginine synthesis, and yet displays a critical dependence on extracellular arginine for survival and proliferation.	Arginine	134-142	argininosuccinate synthetase 1	Mus musculus	61-87
24047141-3	2013	We have developed a decapeptide analog [D-Tyr(45),D-Trp(47),azaGly(51),Arg(Me)(53)]metastin(45-54) with improved serum stability compared with metastin(45-54) but with decreased KISS1R agonistic activity.	Arginine	71-74	KiSS-1 metastasis-suppressor	Rattus norvegicus	83-91
24047141-5	2013	N-terminal truncation resulted in a stable nonapeptide, [D-Tyr(46),D-Pya(4)(47),azaGly(51),Arg(Me)(53)]metastin(46-54), compound 26, which displayed KISS1R binding affinities comparable to metastin(45-54) and had improved serum stability.	Arginine	91-94	KiSS-1 metastasis-suppressor	Rattus norvegicus	103-111
34433661-2	2021	Acute myeloid leukemia (AML) downregulates the expression of argininosuccinate synthase (ASS1), a recognized rate-limiting enzyme for arginine synthesis, and yet displays a critical dependence on extracellular arginine for survival and proliferation.	Arginine	134-142	argininosuccinate synthetase 1	Mus musculus	89-93
24140420-5	2013	EPG-11/PRMT-1 directly methylates arginines in the RGG domains of PGL-1 and PGL-3.	Arginine	34-43	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	7-13
34433661-2	2021	Acute myeloid leukemia (AML) downregulates the expression of argininosuccinate synthase (ASS1), a recognized rate-limiting enzyme for arginine synthesis, and yet displays a critical dependence on extracellular arginine for survival and proliferation.	Arginine	210-218	argininosuccinate synthetase 1	Mus musculus	61-87
34524407-3	2021	We previously demonstrated that JP2 is cleaved by calpain-1 (CAPN1) between Arginine 565 (R565) and Threonine 566 (T566).	Arginine	76-84	calpain 1	Homo sapiens	50-59
23959939-9	2013	Taken together these findings identify L-arginine as a GLP-1 secretagogue in vivo and demonstrate that improvement of glucose tolerance by oral L-arginine depends on GLP-1R-signaling.	Arginine	144-154	glucagon-like peptide 1 receptor	Mus musculus	166-172
34524407-3	2021	We previously demonstrated that JP2 is cleaved by calpain-1 (CAPN1) between Arginine 565 (R565) and Threonine 566 (T566).	Arginine	76-84	calpain 1	Homo sapiens	61-66
34599156-3	2021	Since ASS1 leads to de novo synthesis of arginine, an important amino acid for the growth of intestinal epithelial cells, its upregulation can contribute to epithelial proliferation necessary to be sustained during oncogenic transformation and regeneration.	Arginine	41-49	argininosuccinate synthetase 1	Mus musculus	6-10
34473496-11	2021	The PIP2 lipids can form long-lasting hydrogen bonds with positively charged residues such as Arg and Lys on hBD-3, thus forming clusters with hBD-3.	Arginine	94-97	defensin beta 103B	Homo sapiens	109-114
34450641-5	2021	Two arginine residues within the GATA-1 linker region mediates direct interaction with HDAC1.	Arginine	4-12	histone deacetylase 1	Mus musculus	87-92
34497269-2	2021	Protein arginine methyltransferase 7 (PRMT7) is the only reported type III enzyme responsible for monomethylation of arginine residue on both histone and nonhistone substrates.	Arginine	117-125	protein arginine N-methyltransferase 7	Mus musculus	0-36
34497269-2	2021	Protein arginine methyltransferase 7 (PRMT7) is the only reported type III enzyme responsible for monomethylation of arginine residue on both histone and nonhistone substrates.	Arginine	117-125	protein arginine N-methyltransferase 7	Mus musculus	38-43
34497269-7	2021	Thus, our results reveal a novel epigenetic mechanism through which PRMT7-mediated histone arginine monomethylation activates Foxm1 transcriptional expression to regulate AMYFs proliferation and differentiation during lung alveologenesis and may represent a potential target for intervention in pulmonary diseases.	Arginine	91-99	protein arginine N-methyltransferase 7	Mus musculus	68-73
34489423-5	2021	Isothermal titration calorimetry and size-exclusion chromatography revealed that proline:arginine (PR) poly-dipeptides tightly bind karyopherin-beta2 (Kapbeta2) at 1:1 ratio.	Arginine	89-97	transportin 1	Homo sapiens	132-149
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	153-186
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	188-193
34500766-3	2021	The results show that cysteine (Cys) can significantly enhance the fluorescence emission of NH2-MIL-101-Fe suspended in water, while NH2-MIL-101-Al exhibits the ability to sense lysine (Lys), arginine (Arg) and histidine (His) in aqueous media via turn-on fluorescence emission.	Arginine	192-200	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	202-205
34466690-4	2021	Compared with IUGR lambs, NCG or Arg administration increased (P < 0.05) the adenosine triphosphate (ATP) level and the activities of complexes I/III/IV, isocitrate dehydrogenase and citrate synthase in the liver.	Arginine	33-36	citrate synthase, mitochondrial	Ovis aries	183-199
34466690-5	2021	Compared with CON lambs, the relative mRNA levels of adenosine monophosphate-activated protein kinase alpha1 (AMPKalpha1), peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC1alpha) and transcription factor A (TFAM) were increased (P < 0.05) in the liver of IUGR lambs, but were decreased (P < 0.05) in the liver of NCG- or Arg-treated lambs compared with those in the IUGR lambs.	Arginine	345-348	transcription factor A, mitochondrial	Ovis aries	231-235
34466690-6	2021	Compared with IUGR lambs, NCG or Arg administration decreased (P < 0.05) the total AMPKalpha (tAMPKalpha)-to-phosphorylated AMPKalpha (pAMPKalpha) ratio and the protein expression of PGC1alpha and TFAM.	Arginine	33-36	transcription factor A, mitochondrial	Ovis aries	197-201
34466690-7	2021	The results suggested that dietary Arg or NCG supplements improved hepatic energy status and mitochondrial function and inhibited the AMPK-PGC1alpha-TFAM pathway in IUGR suckling lambs.	Arginine	35-38	transcription factor A, mitochondrial	Ovis aries	149-153
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	cyclin CLN1	Saccharomyces cerevisiae S288C	52-56
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	mitogen-activated protein kinase kinase STE7	Saccharomyces cerevisiae S288C	169-173
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	Spc29p	Saccharomyces cerevisiae S288C	246-251
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	Spc110p	Saccharomyces cerevisiae S288C	260-266
34340539-5	2021	Three of these ligands, arginine, fumarate, and cysteine, were TlpA-dependent chemoattractants, while the others elicited no response.	Arginine	24-32	cysteine rich protein 3	Homo sapiens	63-67
34452909-2	2021	Peptidylarginine deiminase 4 (PADI4) catalyzes the deimination of histone arginine residues to citrulline.	Arginine	74-82	peptidyl arginine deiminase 4	Homo sapiens	0-28
34452909-2	2021	Peptidylarginine deiminase 4 (PADI4) catalyzes the deimination of histone arginine residues to citrulline.	Arginine	74-82	peptidyl arginine deiminase 4	Homo sapiens	30-35
34439844-8	2021	Using site-directed mutagenesis and molecular dynamics simulations, we showed that arginine 79 of ANT1 is crucial for the DNP-mediated increase of membrane conductance, implying that this amino acid participates in DNP binding to ANT1.	Arginine	83-91	solute carrier family 25 member 4	Homo sapiens	98-102
34439844-8	2021	Using site-directed mutagenesis and molecular dynamics simulations, we showed that arginine 79 of ANT1 is crucial for the DNP-mediated increase of membrane conductance, implying that this amino acid participates in DNP binding to ANT1.	Arginine	83-91	solute carrier family 25 member 4	Homo sapiens	230-234
34292355-2	2021	To understand the biological roles of arginine biosynthesis in pathogenic fungi, we used Cpa1, the carbamoyl phosphate synthase arginine-specific small chain subunit in Saccharomyces cerevisiae as a query to identify its ortholog in the Magnaporthe oryzae genome and named it MoCpa1.	Arginine	38-46	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	89-93
34361805-1	2021	The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine demethylation and lysine hydroxylation of histone and a growing list of its known substrate molecules, including p53 and U2AF65, suggesting a possible role in mRNA splicing and transcription in cancer progression.	Arginine	67-75	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	4-39
34361805-1	2021	The jumonji domain-containing protein 6 (JMJD6) gene catalyzes the arginine demethylation and lysine hydroxylation of histone and a growing list of its known substrate molecules, including p53 and U2AF65, suggesting a possible role in mRNA splicing and transcription in cancer progression.	Arginine	67-75	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	41-46
34359242-0	2021	Methionine and Arginine Supply Alters Abundance of Amino Acid, Insulin Signaling, and Glutathione Metabolism-Related Proteins in Bovine Subcutaneous Adipose Explants Challenged with N-Acetyl-d-sphingosine.	Arginine	15-23	insulin	Bos taurus	63-70
34359242-1	2021	The objective was to perform a proof-of-principle study to evaluate the effects of methionine (Met) and arginine (Arg) supply on protein abundance of amino acid, insulin signaling, and glutathione metabolism-related proteins in subcutaneous adipose tissue (SAT) explants under ceramide (Ce) challenge.	Arginine	114-117	insulin	Bos taurus	162-169
34335265-5	2021	Additionally, the potentiation of the NO level by L-arginine reversed the effects of the inhibition of GluN2B.	Arginine	50-60	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	103-109
24205020-7	2013	In subgroup analyses, we observed an increased risk of XRCC1 399 Arg/Gln genotype for HNSCC in Caucasians (OR = 1.20, 95% CI: 1.00-1.44) and Gln/Gln genotype for larynx squamous cell carcinoma (OR = 1.63, 95% CI: 1.10-2.40).	Arginine	65-68	X-ray repair cross complementing 1	Homo sapiens	55-60
34371816-0	2021	A Cross-Talk between the Erythrocyte L-Arginine/ADMA/Nitric Oxide Metabolic Pathway and the Endothelial Function in Subjects with Type 2 Diabetes Mellitus.	Arginine	37-47	bone morphogenetic protein receptor type 2	Homo sapiens	8-12
23954696-5	2013	Moreover, recombinant BjC3a-desArg (generated by removal of the C-terminal arginine), like mammalian C3a-desArg, retained the immunological activities of BjC3a such as antibacterial and respiratory burst-stimulating activities, indicating that the immunological functions of C3a-desArg were conserved throughout chordate evolution.	Arginine	75-83	complement C3	Homo sapiens	24-27
34212252-6	2022	Using intestinal epithelial cell culture, we demonstrated that the lipid-lowering effect of L-arginine was mainly mediated by activating the AMP-activated protein kinase (AMPK) signaling pathway, carnitine palmitoyltransferase 1 (CPT1), and PPARalpha, as well as mRNA levels for Acox1 and Acox2.	Arginine	92-102	peroxisome proliferator-activated receptor alpha	Oreochromis niloticus	241-250
23885084-2	2013	Multiple-sequence alignments of A19 homologs indicated conservation of a series of lysines and arginines, which could represent a nuclear localization or nucleic acid binding motif, and a pair of CXXC motifs that suggested a zinc finger or redox active sites.	Arginine	95-104	immunoglobulin kappa variable 2-28	Homo sapiens	32-35
23885084-5	2013	Epitope-tagged A19 proteins were detected in the nucleus and cytoplasm in both infected and uninfected cells, but this distribution was unaffected by alanine substitutions of the arginine residues, which only partially reduced the ability of the mutated protein to trans-complement infectivity.	Arginine	179-187	immunoglobulin kappa variable 2-28	Homo sapiens	15-18
34212252-6	2022	Using intestinal epithelial cell culture, we demonstrated that the lipid-lowering effect of L-arginine was mainly mediated by activating the AMP-activated protein kinase (AMPK) signaling pathway, carnitine palmitoyltransferase 1 (CPT1), and PPARalpha, as well as mRNA levels for Acox1 and Acox2.	Arginine	92-102	peroxisomal acyl-coenzyme A oxidase 1	Oreochromis niloticus	279-284
34262438-2	2021	Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been identified in patients with autism spectrum disorder (ASD).	Arginine	45-53	neuroligin 3	Homo sapiens	121-133
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	inosine triphosphatase	Homo sapiens	60-66
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	KRAS proto-oncogene, GTPase	Homo sapiens	116-119
34262438-2	2021	Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid residue (R451C) of neuroligin-3 (NLGN3), have been identified in patients with autism spectrum disorder (ASD).	Arginine	45-53	neuroligin 3	Homo sapiens	135-140
34088793-4	2021	We hypothesized that arginine bioavailability would be low in patients with COVID-19 and multisystem inflammatory syndrome in children (MIS-C).	Arginine	21-29	anti-Mullerian hormone	Homo sapiens	136-139
23747316-10	2013	To evaluate if the arginine residues are essential for AUF1-RGG activity, the methylatable arginines in the AUF1-3RGG peptide were mutated to lysine or alanine.	Arginine	91-100	heterogeneous nuclear ribonucleoprotein D	Mus musculus	108-112
23747316-14	2013	In summary, arginines in the RGG domain of AUF1 are methylated, and AUF1-RGG peptides may be novel reagents that reduce macrophage activation in inflammation.	Arginine	12-21	heterogeneous nuclear ribonucleoprotein D	Mus musculus	43-47
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Arginine	215-218	X-ray repair cross complementing 1	Homo sapiens	158-163
34088793-9	2021	Mean plasma arginine and arginine bioavailability ratios were lower among adult and pediatric patients with COVID-19/MIS-C compared to controls.	Arginine	12-20	anti-Mullerian hormone	Homo sapiens	117-120
23868824-1	2013	Protein allylation and fluorophore targeting: Arginine residues of the yeast nuclear ribonucleoprotein Npl3 were extensively modified by Hmt1-catalyzed allylation reaction with allyl-SAM as the allyl group donor.	Arginine	46-54	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	103-107
34088793-9	2021	Mean plasma arginine and arginine bioavailability ratios were lower among adult and pediatric patients with COVID-19/MIS-C compared to controls.	Arginine	25-33	anti-Mullerian hormone	Homo sapiens	117-120
34088793-11	2021	Adults and children with COVID-19 and MIS-C in our cohort had low arginine bioavailability compared to healthy adult controls.	Arginine	66-74	anti-Mullerian hormone	Homo sapiens	38-41
34222255-5	2021	Here, we demonstrate that endothelial dysfunction resulting from knockout of both Rap1A and Rap1B isoforms is ameliorated by exogenous L-Arg administration to rescue NO-dependent vasorelaxation and blood pressure.	Arginine	135-140	RAP1A, member of RAS oncogene family	Homo sapiens	82-87
23517691-7	2013	Finally, the exceptional epidemiological success of the USA300 CA-MRSA clone in particular may have been due to yet another gene acquisition, namely that of the speG gene, which is located on the arginine catabolic mobile element (ACME) and involved in detoxifying harmful host-derived polyamines.	Arginine	196-204	striated muscle enriched protein kinase	Homo sapiens	161-165
34134783-12	2021	Arg 394 is located at the GSK3beta binding domain of Axin2 protein, which is highly conserved across species.	Arginine	0-3	axin 2	Mus musculus	53-58
23760243-9	2013	The latter function of N was shown to depend on both of the RNA-binding domains of N, as well as on the serine- and arginine-rich central region of N, which binds nsp3.	Arginine	116-124	SH2 domain containing 3C	Homo sapiens	163-167
34133469-6	2021	Sugar donor competition assays demonstrated that UDP-glucose was the preferred substrate of NleB2 and peptide sequencing identified the glycosylation site within RIPK1 as Arg603, indicating that NleB2 catalyses arginine glucosylation.	Arginine	211-219	receptor interacting serine/threonine kinase 1	Homo sapiens	162-167
23943859-6	2013	Map-based cloning revealed that CAU1 encodes the H4R3sme2 (for histone H4 Arg 3 with symmetric dimethylation)-type histone methylase protein arginine methytransferase5/Shk1 binding protein1.	Arginine	74-77	SHK1 binding protein 1	Arabidopsis thaliana	32-36
23943859-6	2013	Map-based cloning revealed that CAU1 encodes the H4R3sme2 (for histone H4 Arg 3 with symmetric dimethylation)-type histone methylase protein arginine methytransferase5/Shk1 binding protein1.	Arginine	74-77	SHK1 binding protein 1	Arabidopsis thaliana	168-189
34070975-7	2021	Further pathway enrichment and network analyses revealed a substantial effect of Cyp17a1 genotype on associated cardiovascular and obesity-related pathways involving aspartate and L-arginine.	Arginine	180-190	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	81-88
23849069-4	2013	HLA-C*03:190 was identical to HLA-C*03:02:01 with the exception of a nucleotide change at codon 131 in exon 3 (CGC TGC), and resulted in the amino acid change from Arginine to Cysteine.	Arginine	164-172	major histocompatibility complex, class I, C	Homo sapiens	0-5
23849069-4	2013	HLA-C*03:190 was identical to HLA-C*03:02:01 with the exception of a nucleotide change at codon 131 in exon 3 (CGC TGC), and resulted in the amino acid change from Arginine to Cysteine.	Arginine	164-172	major histocompatibility complex, class I, C	Homo sapiens	30-35
34217162-7	2021	Glycine, serine and threonine metabolism, arginine and proline metabolism, TGF-beta signaling pathway, and pathways in cancer were significantly enriched in DEGs2 and DEGs4.	Arginine	42-50	delta 4-desaturase, sphingolipid 2	Homo sapiens	157-162
23681796-6	2013	Overall, there was a significant association between XRCC1 Arg194Trp polymorphism and oral cancer risk (for Trp versus Arg: OR = 1.41, 95 % CI 1.08-1.83, P = 0.01; for TrpTrp versus ArgArg: OR = 1.50, 95 % CI 1.00-2.30, P = 0.05; for TrpTrp/ArgTrp versus ArgArg: OR = 1.49, 95 % CI 1.14-1.94, P = 0.003).	Arginine	59-62	X-ray repair cross complementing 1	Homo sapiens	53-58
34062765-0	2021	The Role of Protein Arginine Methylation as Post-Translational Modification on Actin Cytoskeletal Components in Neuronal Structure and Function.	Arginine	20-28	solute carrier family 35 member G1	Homo sapiens	44-48
23840065-3	2013	Endothelial Abl deletion in Arg-null mice led to late-stage embryonic and perinatal lethality, with mutant mice displaying focal loss of vasculature and tissue necrosis.	Arginine	28-31	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	12-15
34062765-5	2021	Arginine methylation represents an important post-translational regulatory mechanism that had previously been mainly associated with controlling nuclear processes.	Arginine	0-8	solute carrier family 35 member G1	Homo sapiens	45-49
23894404-6	2013	A significantly shorter OS was observed among stage II/III colon cancer patients with the XRCC1 Gln allelic variants (HR  =1.69, 95% CI  =1.06-2.71), compared to those with XRCC1 Arg/Arg genotype.	Arginine	183-186	X-ray repair cross complementing 1	Homo sapiens	90-95
23714778-4	2013	Tdrkh partners with Miwi and Miwi2 via symmetrically dimethylated arginine residues in Miwi and Miwi2.	Arginine	66-74	piwi like RNA-mediated gene silencing 1	Homo sapiens	20-24
23714778-4	2013	Tdrkh partners with Miwi and Miwi2 via symmetrically dimethylated arginine residues in Miwi and Miwi2.	Arginine	66-74	piwi like RNA-mediated gene silencing 1	Homo sapiens	29-33
34210178-1	2021	A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs containing Glun2B subunits within the spinal cord and lacks motor side effects commonly associated with non-subunit-selective NMDAr antagonism, namely sedation and motor impairment.	Arginine	25-35	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	92-98
34210178-1	2021	A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs containing Glun2B subunits within the spinal cord and lacks motor side effects commonly associated with non-subunit-selective NMDAr antagonism, namely sedation and motor impairment.	Arginine	25-35	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	207-212
35452957-5	2022	The region of p62 where NEDD4 binds is located at the proline- and arginine (PR)-rich region (amino acids: 102-119), C-terminal extension of the Phox and Bem1 (PB1) domain.	Arginine	67-75	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	24-29
23647072-11	2013	The variant in KCNH5 alters one of the highly conserved arginine residues of the voltage sensor of the encoded voltage-gated potassium channel.	Arginine	56-64	potassium voltage-gated channel subfamily H member 5	Homo sapiens	15-20
35436466-1	2022	Peptidylarginine deiminase-4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine into citrulline of macromolecules in the body.	Arginine	99-107	peptidyl arginine deiminase 4	Homo sapiens	0-28
23666621-6	2013	Simultaneous substitution of arginine for the two lysines prevented Tat1 degradation, but substitution of either of them alone did not, indicating that the roles of lysines 29 and 31 are redundant.	Arginine	29-37	amino acid transporter TAT1	Saccharomyces cerevisiae S288C	68-72
23562678-1	2013	An Arg-Gly-Asp (RGD) motif in the fourth FAS1 domain of the human BIGH3 (transforming growth factor-beta1-inducible gene-h3) protein has been reported to play an important role in mediating tumor angiogenesis.	Arginine	3-6	transforming growth factor beta induced	Homo sapiens	66-71
35436466-1	2022	Peptidylarginine deiminase-4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine into citrulline of macromolecules in the body.	Arginine	99-107	peptidyl arginine deiminase 4	Homo sapiens	30-34
35613513-1	2022	Arginine releases proinsulin from binding to UGGT1 in the endoplasmic reticulum (ER).	Arginine	0-8	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	45-50
23589577-10	2013	Arginine depletion by ADI significantly increased tumor necrosis factor alpha and decreased interleukin-10 (IL-10) and IL-12p40 secretion.	Arginine	0-8	interleukin 10	Homo sapiens	92-106
23589577-10	2013	Arginine depletion by ADI significantly increased tumor necrosis factor alpha and decreased interleukin-10 (IL-10) and IL-12p40 secretion.	Arginine	0-8	interleukin 10	Homo sapiens	108-113
35613513-8	2022	At the molecular level, less interaction of proinsulin with UGGT1 was observed in both human UGGT1R1526C and mouse UGGT1L1518C with/without arginine.	Arginine	140-148	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	60-65
23435265-6	2013	Compared with NRG, ARG showed significantly high serum levels of KIM-1 on day 0 (pre-KTx) and on the 1st, 4th, and 7th post-KTx days, and significantly high OPN levels on day 0 and the 7th day.	Arginine	19-22	hepatitis A virus cellular receptor 1	Homo sapiens	65-70
35613513-8	2022	At the molecular level, less interaction of proinsulin with UGGT1 was observed in both human UGGT1R1526C and mouse UGGT1L1518C with/without arginine.	Arginine	140-148	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	93-98
35590365-0	2022	Arginine regulates inflammation response-induced by Fowl Adenovirus serotype 4 via JAK2/STAT3 pathway.	Arginine	0-8	Janus kinase 2	Gallus gallus	83-87
23671278-6	2013	In the ligand, Hp Arg-252 and Lys-262, both present in a previously identified CD163 binding loop of Hp, were revealed as essential residues for the high affinity receptor binding.	Arginine	18-21	CD163 molecule	Homo sapiens	79-84
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	73-81	interleukin 1, beta	Gallus gallus	193-201
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	73-81	Janus kinase 2	Gallus gallus	241-245
35470495-6	2022	Compared to the control group, the anti-inflammatory action of l-arginine is reflected by upregulation of hepatic interleukin-10 (IL-10) and the suppression of hepatic cyclooxygenase-2, tumor necrotic factor alpha, IL-1beta, and IL-6 expressions in growing rats.	Arginine	63-73	interleukin 10	Rattus norvegicus	114-128
23629733-5	2013	PriC/SSB complex formation requires evolutionarily conserved residues from both proteins, including a pair of Arg residues from PriC and the C terminus of SSB.	Arginine	110-113	single-stranded DNA-binding protein	Escherichia coli	5-8
35470495-6	2022	Compared to the control group, the anti-inflammatory action of l-arginine is reflected by upregulation of hepatic interleukin-10 (IL-10) and the suppression of hepatic cyclooxygenase-2, tumor necrotic factor alpha, IL-1beta, and IL-6 expressions in growing rats.	Arginine	63-73	interleukin 10	Rattus norvegicus	130-135
35442741-6	2022	Human cancer-associated moesin mutations at the conserved arginine-295 residue similarly enhanced MLL-ENL-driven leukemogenesis.	Arginine	58-66	lysine methyltransferase 2A	Homo sapiens	98-101
23564306-3	2013	Within the NT, nitric oxide (NO), produced via L-arginine oxidation by neuronal nitric oxide synthase (nNOS), buffers the pressor response to EPR activation.	Arginine	47-57	nitric oxide synthase 1	Rattus norvegicus	71-101
23564306-3	2013	Within the NT, nitric oxide (NO), produced via L-arginine oxidation by neuronal nitric oxide synthase (nNOS), buffers the pressor response to EPR activation.	Arginine	47-57	nitric oxide synthase 1	Rattus norvegicus	103-107
35442741-6	2022	Human cancer-associated moesin mutations at the conserved arginine-295 residue similarly enhanced MLL-ENL-driven leukemogenesis.	Arginine	58-66	MLLT1 super elongation complex subunit	Homo sapiens	102-105
35383285-6	2022	Analysis of the expression, activity and oligomerisation of the P. stuartii Adc further highlights the distinct properties of this unusual protein and lays a platform for future investigation of the role of supramolecular assembly in the superfamily or arginine and lysine decarboxylases.	Arginine	253-261	antizyme inhibitor 2	Homo sapiens	76-79
23552693-0	2013	beta1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.	Arginine	25-28	integrin subunit beta 1	Homo sapiens	0-14
23552693-6	2013	Furthermore, beta1 integrin interacts with the tyrosine kinase Arg and stimulates Arg-dependent phosphorylation of cortactin on tyrosine 421.	Arginine	63-66	integrin subunit beta 1	Homo sapiens	13-27
23552693-6	2013	Furthermore, beta1 integrin interacts with the tyrosine kinase Arg and stimulates Arg-dependent phosphorylation of cortactin on tyrosine 421.	Arginine	82-85	integrin subunit beta 1	Homo sapiens	13-27
23552693-6	2013	Furthermore, beta1 integrin interacts with the tyrosine kinase Arg and stimulates Arg-dependent phosphorylation of cortactin on tyrosine 421.	Arginine	82-85	cortactin	Homo sapiens	115-124
35357495-3	2022	An earlier report showed that the sharp decrease in hypocotyl growth rapidly induced by R was accompanied by an equally rapid decrease in the transcript and protein levels of two closely related apyrases (nucleoside triphosphate-diphosphohydrolases) in Arabidopsis (Arabidopsis thaliana), APY1 and APY2, enzymes whose expression alters auxin transport and growth in seedlings.	Arginine	88-89	apyrase 1	Arabidopsis thaliana	289-293
35402258-6	2022	The second modification engineered in M7S was designed to enhance the stability of MDA-7 (IL-24), which was accomplished by replacing lysine at position K122 with arginine.	Arginine	163-171	interleukin 24	Homo sapiens	83-88
23651498-2	2013	Integrin alphavbeta3 can be imaged with arginine-glycine-aspartic acid (RGD) peptide agents.	Arginine	40-48	integrin subunit alpha V	Homo sapiens	0-20
35402258-6	2022	The second modification engineered in M7S was designed to enhance the stability of MDA-7 (IL-24), which was accomplished by replacing lysine at position K122 with arginine.	Arginine	163-171	interleukin 24	Homo sapiens	90-95
35081374-1	2022	PADI4 (protein-arginine deiminase, also known as protein l-arginine iminohydrolase) is one of the human isoforms of a family of Ca2+-dependent proteins catalyzing the conversion of arginine to citrulline.	Arginine	181-189	peptidyl arginine deiminase 4	Homo sapiens	0-5
23720861-16	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Homo sapiens	31-42
23718875-10	2013	Long-term exposure of ARG with or without CMP-C or L-NAME suppressed NO2-/NO3-, glucose uptake, GLUT-1, AMPK expression and activity below control, and increased overall cellular glucose, O2 - and ONOO-.	Arginine	22-25	solute carrier family 2 member 1	Homo sapiens	96-102
23718875-12	2013	Continuous co-incubation with CDB and ARG increased NO2-/NO3-, glucose uptake, GLUT-1, AMPK expression and activity, and maintained overall cellular glucose, O2 - and ONOO- to control conditions.	Arginine	38-41	solute carrier family 2 member 1	Homo sapiens	79-85
23589299-7	2013	Furthermore, misinsertion of arginine in place of Sec was commonly observed in GPx1 and glutathione peroxidase 4.	Arginine	29-37	glutathione peroxidase 1	Homo sapiens	79-83
35433176-1	2022	Citrullinemia type 1 is an autosomal recessive metabolic disease caused by ASS1 gene mutations encoding argininosuccinic acid synthetase enzyme which is within the pathway of arginine and nitric oxide biosynthesis.	Arginine	175-183	argininosuccinate synthase 1	Homo sapiens	75-79
23684312-6	2013	Surprisingly, five serine/arginine-rich (SR) proteins involved in messenger RNA splicing, including the splicing factor SRm300 (SRRM2), were differentially phosophorylated.	Arginine	26-34	serine/arginine repetitive matrix 2	Homo sapiens	120-126
23684312-6	2013	Surprisingly, five serine/arginine-rich (SR) proteins involved in messenger RNA splicing, including the splicing factor SRm300 (SRRM2), were differentially phosophorylated.	Arginine	26-34	serine/arginine repetitive matrix 2	Homo sapiens	128-133
34993747-4	2022	NET inhibitors or other molecules involved in the NET formation, such as the protein arginine deiminase 4 (PAD4) enzyme, an arginine-to-citrulline converter, participate in chromatin condensation and NET formation, is the basis of this therapeutic approach.	Arginine	124-132	peptidyl arginine deiminase 4	Homo sapiens	77-105
23557067-0	2013	Effect of L-arginine on HSP70 expression in liver in weanling piglets.	Arginine	10-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
34993747-4	2022	NET inhibitors or other molecules involved in the NET formation, such as the protein arginine deiminase 4 (PAD4) enzyme, an arginine-to-citrulline converter, participate in chromatin condensation and NET formation, is the basis of this therapeutic approach.	Arginine	124-132	peptidyl arginine deiminase 4	Homo sapiens	107-111
23557067-5	2013	The immunohistochemical localization of HSP70 in liver revealed strong expression in the Arg group.	Arginine	89-92	heat shock protein family A (Hsp70) member 4	Homo sapiens	40-45
23557067-6	2013	Arg increased HSP70 mRNA and HSP70 expression in the liver (P &lt; 0.05).	Arginine	0-3	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
35296003-1	2022	DNMT3A mutations play a prominent role in clonal hematopoiesis and myeloid neoplasms with arginine (R)882 as a hotspot, however the clinical implications of R882 vs. non-R882 mutations in myeloid neoplasms like myelodysplastic syndrome (MDS) is unclear.	Arginine	90-98	DNA methyltransferase 3 alpha	Homo sapiens	0-6
23557067-6	2013	Arg increased HSP70 mRNA and HSP70 expression in the liver (P &lt; 0.05).	Arginine	0-3	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
23557067-7	2013	CONCLUSIONS: These findings suggest that dietary supplementation with Arg could maintain liver health by inducing HSP70 expression in weanling piglets.	Arginine	70-73	heat shock protein family A (Hsp70) member 4	Homo sapiens	114-119
23509291-5	2013	The Atg13 HORMA structure reveals a pair of conserved Arg residues that constitute a putative phosphate sensor.	Arginine	54-57	autophagy related 13	Homo sapiens	4-9
23509291-7	2013	These two Arg residues are essential for autophagy, suggesting that the Atg13 HORMA domain could function as a phosphoregulated conformational switch.	Arginine	10-13	autophagy related 13	Homo sapiens	72-77
35089423-10	2022	Mechanistic studies reveal that methylation of arginine residue 93 in beta-catenin decreases the activity of beta-catenin.	Arginine	47-55	catenin beta 1	Rattus norvegicus	70-82
23341458-6	2013	N-terminal sequencing indicated that pro-BMP-2 was cleaved by FSAP at the canonical PC cleavage site, giving rise to mature BMP-2 (Arg(282) Gln(283)), as well as in the N-terminal heparin binding region of mature BMP-2, generating a truncated mature BMP-2 peptide (Arg(289) Lys(290)).	Arginine	131-134	hyaluronan binding protein 2	Homo sapiens	62-66
23384727-0	2013	Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma.	Arginine	0-8	interferon beta 1, fibroblast	Mus musculus	38-53
23548524-4	2013	METHODS: We conducted a retrospective analysis of the effects of ADRB2 haplotypes at position 16 (Gly/Arg) and 27(Gln/Glu) in 449 patients with a physician diagnosis of asthma who were responsive to methacholine (ie, provocation concentration that caused a decrease in forced expiratory volume in 1 second [FEV(1)] of 20% [PC(20)], &lt;8 mg/mL).	Arginine	102-105	adrenoceptor beta 2	Homo sapiens	65-70
23425027-3	2013	The XRCC1 codon 280 His carriers (Arg/His+His/His) held a significantly lower risk of distant metastasis in the dominant model (Pearson chi-square test P=0.019).	Arginine	34-37	X-ray repair cross complementing 1	Homo sapiens	4-9
23373819-1	2013	A recent ion mobility-mass spectrometry (IM-MS) study of the nonapeptide bradykinin (BK, amino acid sequence Arg(1)-Pro(2)-Pro(3)-Gly(4)-Phe(5)-Ser(6)-Pro(7)-Phe(8)-Arg(9)) found evidence for 10 populations of conformations that depend upon the solution composition [J.	Arginine	109-112	pyrroline-5-carboxylate reductase 1	Homo sapiens	123-128
23237781-11	2013	A molecular model of human GLYAT containing coenzyme A (CoA) was generated which revealed that the inactivity of the R199C variant could be due to the substitution of the highly conserved Arg(199) and destabilisation of an alpha-loop-alpha motif which is important for substrate binding in the GNAT superfamily.	Arginine	188-191	glycine-N-acyltransferase	Homo sapiens	27-32
23288839-7	2013	Residues Arg-69 and Arg-72 are critical because their mutation abolishes FGE processing.	Arginine	9-12	sulfatase modifying factor 1	Homo sapiens	73-76
23288839-7	2013	Residues Arg-69 and Arg-72 are critical because their mutation abolishes FGE processing.	Arginine	20-23	sulfatase modifying factor 1	Homo sapiens	73-76
23299939-4	2013	As observed with the THO complex subunit Thoc5, Chtop binds to the NTF2-like domain of Nxf1, and this interaction requires arginine methylation of Chtop.	Arginine	123-131	THO complex 5	Homo sapiens	41-46
23299939-4	2013	As observed with the THO complex subunit Thoc5, Chtop binds to the NTF2-like domain of Nxf1, and this interaction requires arginine methylation of Chtop.	Arginine	123-131	nuclear RNA export factor 1	Homo sapiens	87-91
23404887-6	2013	CDKG1 contains N-terminal Ser/Arg (RS) motifs and interacts with splicing factor Arginine/Serine-Rich Zinc Knuckle-Containing Protein33 (RSZ33) through its RS region to regulate proper splicing.	Arginine	30-33	Protein kinase superfamily protein	Arabidopsis thaliana	0-5
23404887-6	2013	CDKG1 contains N-terminal Ser/Arg (RS) motifs and interacts with splicing factor Arginine/Serine-Rich Zinc Knuckle-Containing Protein33 (RSZ33) through its RS region to regulate proper splicing.	Arginine	30-33	arginine/serine-rich zinc knuckle-containing protein 33	Arabidopsis thaliana	137-142
23081893-0	2013	Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy.	Arginine	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	63-67
23081893-14	2013	These data indicated that dietary arginine supplementation during early pregnancy could enhance embryo implantation through stimulation of PI3K/PKB/mTOR/NO signaling pathway.	Arginine	34-42	mechanistic target of rapamycin kinase	Rattus norvegicus	148-152
23125209-10	2013	Also, arginine treatment reduced HIF-1alpha, as well as VEGF expression in normoxic BERK mice, supporting a role of NO bioavailability in HIF-1alpha activation.	Arginine	6-14	vascular endothelial growth factor A	Mus musculus	56-60
24175813-0	2013	The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer in Indians.	Arginine	14-17	X-ray repair cross complementing 1	Homo sapiens	22-27
24175813-3	2013	Two variants of XRCC1gene (at codon 399), Gln/Gln and Arg/Gln, have been shown to be related to lowered DNA repair capacity and increased genomic instability in multiple studies.	Arginine	54-57	X-ray repair cross complementing 1	Homo sapiens	16-21
24175813-13	2013	CONCLUSIONS: It is concluded that XRCC1 genotypes Gln/Gln and Arg/Gln may influence cancer susceptibility in patients with smoking habits and these functional SNPs in XRCC1 gene may act as attractive candidate biomarkers in lung cancer for diagnosis and prognosis.	Arginine	62-65	X-ray repair cross complementing 1	Homo sapiens	167-172
23534753-5	2013	The Cox"s regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype.	Arginine	126-129	X-ray repair cross complementing 1	Homo sapiens	58-63
23534753-5	2013	The Cox"s regression analysis showed individuals carrying XRCC1 399Trp/Trp genotype had 0.55 fold risk of death from HCC than Arg/Arg genotype.	Arginine	130-133	X-ray repair cross complementing 1	Homo sapiens	58-63
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	96-99	MDM2 proto-oncogene	Homo sapiens	34-38
23210739-4	2013	On gene-gene interactions between MDM2 and p53 polymorphisms, the frequency of MDM2 G/G and p53 Arg/Arg together was found to be 6.5-fold higher in cervical cancer patients compared with healthy controls (OR=6.497; 95% CI=2.987-14.13; p&lt;0.0001).	Arginine	100-103	MDM2 proto-oncogene	Homo sapiens	34-38
23210739-6	2013	In conclusion, Arginine at codon72 of p53 and GG genotype at 309 in P2 of MDM2 together reveal a direct proportionality with the tumor grade of cervical cancer along with HPV infection in postmenopausal women.	Arginine	15-23	MDM2 proto-oncogene	Homo sapiens	74-78
23806011-2	2013	In the first case, a new delta-globin variant, Hb A2-Pierre-Benite [delta83(EF7)Gly Arg; HBD: c.250G&gt;C] is associated with Hb Groene Hart [alpha119(H2)Pro Ser (alpha1); HBA1: c.358C&gt;T], an alpha-thalassemic variant.	Arginine	84-87	FAM3 metabolism regulating signaling molecule D	Homo sapiens	76-79
23806011-2	2013	In the first case, a new delta-globin variant, Hb A2-Pierre-Benite [delta83(EF7)Gly Arg; HBD: c.250G&gt;C] is associated with Hb Groene Hart [alpha119(H2)Pro Ser (alpha1); HBA1: c.358C&gt;T], an alpha-thalassemic variant.	Arginine	84-87	HBD	Homo sapiens	89-92
23964556-5	2013	CONCLUSIONS: Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.	Arginine	84-87	adrenoceptor beta 2	Homo sapiens	78-83
23430561-9	2013	PNPO gene sequencing identified a homozygous mutation in a highly conserved area in exon 3: c.352G&gt;A p.G118R, predicting substitution of arginine for glycine.	Arginine	140-148	pyridoxamine 5'-phosphate oxidase	Homo sapiens	0-4
23505388-1	2013	Protein arginine methyltransferase 4 (PRMT4)-dependent methylation of arginine residues in histones and other chromatin-associated proteins plays an important role in the regulation of gene expression.	Arginine	8-16	coactivator associated arginine methyltransferase 1	Homo sapiens	38-43
23424623-3	2013	It has been reported that arginase II (ARG2), one of two ARGs, is aberrantly expressed in prostate cancer cells, which convert arginine into ornithine, resulting in a lack of arginine that weakens tumor-infiltrating lymphocytes and renders them dysfunctional.	Arginine	57-61	arginase 2	Homo sapiens	39-43
23424623-3	2013	It has been reported that arginase II (ARG2), one of two ARGs, is aberrantly expressed in prostate cancer cells, which convert arginine into ornithine, resulting in a lack of arginine that weakens tumor-infiltrating lymphocytes and renders them dysfunctional.	Arginine	127-135	arginase 2	Homo sapiens	39-43
23424623-3	2013	It has been reported that arginase II (ARG2), one of two ARGs, is aberrantly expressed in prostate cancer cells, which convert arginine into ornithine, resulting in a lack of arginine that weakens tumor-infiltrating lymphocytes and renders them dysfunctional.	Arginine	175-183	arginase 2	Homo sapiens	39-43
23383209-4	2013	In this report, we demonstrate that the c-Abl/Arg inhibitor, imatinib (imatinib mesylate, STI571, Gleevec), reverses intrinsic and acquired resistance to the anthracycline, doxorubicin, by inducing G2/M arrest and promoting apoptosis in cancer cells expressing highly active c-Abl and Arg.	Arginine	46-49	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-45
23383209-4	2013	In this report, we demonstrate that the c-Abl/Arg inhibitor, imatinib (imatinib mesylate, STI571, Gleevec), reverses intrinsic and acquired resistance to the anthracycline, doxorubicin, by inducing G2/M arrest and promoting apoptosis in cancer cells expressing highly active c-Abl and Arg.	Arginine	46-49	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	275-280
23383209-4	2013	In this report, we demonstrate that the c-Abl/Arg inhibitor, imatinib (imatinib mesylate, STI571, Gleevec), reverses intrinsic and acquired resistance to the anthracycline, doxorubicin, by inducing G2/M arrest and promoting apoptosis in cancer cells expressing highly active c-Abl and Arg.	Arginine	285-288	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-45
23461200-4	2012	The incubation of cells with L-arginine creates conditions for switching on the signal pathway with participation of eNOS --&gt; NO --&gt; sGC --&gt; cGMP --&gt; PKG --&gt; CD38 --&gt; RyR --&gt; Ca2+ and for switching of the PLC - IP3R-dependent pathway.	Arginine	29-39	CD38 antigen	Mus musculus	173-177
23012369-9	2012	In this study, we explored the development of appetite-reducing peptides by synthesizing MC4R agonists based on the insertion of the His-Phe-Arg-Trp sequence into the cyclotide kalata B1.	Arginine	141-144	melanocortin 4 receptor	Homo sapiens	89-93
23043141-2	2012	RESULTS: Mutational analyses of Sdh1 implicate C-terminal region Arg residues involvement in covalent flavinylation and SDH assembly.	Arginine	65-68	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	32-36
23043141-2	2012	RESULTS: Mutational analyses of Sdh1 implicate C-terminal region Arg residues involvement in covalent flavinylation and SDH assembly.	Arginine	65-68	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	120-123
23043141-6	2012	We show presently that flavinylation of the Sdh1 subunit of succinate dehydrogenase is dependent on a set of two spatially close C-terminal arginine residues that are distant from the FAD binding site.	Arginine	140-148	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	44-48
23043141-6	2012	We show presently that flavinylation of the Sdh1 subunit of succinate dehydrogenase is dependent on a set of two spatially close C-terminal arginine residues that are distant from the FAD binding site.	Arginine	140-148	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	60-83
23043141-8	2012	Mutation of Arg(638) compromises SDH function only when present in combination with a Cys(630) substitution.	Arginine	12-15	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	33-36
35089423-10	2022	Mechanistic studies reveal that methylation of arginine residue 93 in beta-catenin decreases the activity of beta-catenin.	Arginine	47-55	catenin beta 1	Rattus norvegicus	109-121
35158834-3	2022	In this study, we developed exosome-capturing anti-CD63 mAb-conjugated small interfering RNAs (siRNAs) with branched Arg linkers and investigated their effects on multiple myeloma (MM) cells.	Arginine	117-120	CD63 molecule	Homo sapiens	51-55
34991562-12	2022	CONCLUSIONS: Treatment with SGLT-2 inhibitors has divergent effects on Arg-related biomarkers and could affect risk estimates associated with these markers.	Arginine	71-74	solute carrier family 5 member 2	Homo sapiens	28-34
23095008-0	2012	Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.	Arginine	46-54	coactivator associated arginine methyltransferase 1	Homo sapiens	80-131
35579969-5	2022	Using metabolomics analysis of sera from NTM-PD patients and mouse models, we showed that the levels of l-arginine were decreased in sera from NTM-PD patients and NTM-infected mice.	Arginine	104-114	neurotrimin	Homo sapiens	41-44
2684616-3	1989	Concerning the N-terminal portion, GLP-1(7-37) amide elicited a clear insulinotropic activity at 0.1 or 1 nM with the perfusate containing 5.5 mM glucose and 5 mM arginine, while 10 nM GLP-1-(1-37) amide, -(6-37) amide, and -(8-37) amide did not.	Arginine	163-171	glucagon	Rattus norvegicus	35-40
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Arginine	174-182	Mig2p	Saccharomyces cerevisiae S288C	22-26
23131016-8	2012	We also show that the Mig2 nuclear import and the binding of Mig2 with Kap95 are not glucose-dependent processes and require a basic NLS motif, located between lysine-32 and arginine-37.	Arginine	174-182	Mig2p	Saccharomyces cerevisiae S288C	61-65
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	eukaryotic translation initiation factor 2A	Homo sapiens	37-46
22366648-10	2012	The second SNP of interest, rs1800561 (4693C&gt;T), leads to the substitution of an arginine (R) at codon 140 by tryptophan (W; R140W) in CD38.	Arginine	84-92	CD38 antigen	Mus musculus	138-142
23115806-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
22497203-1	2012	A single nucleotide polymorphism (C/T) in bovine leptin, resulting in an arginine to cysteine amino acid substitution (p.Arg25Cys), has previously been shown to have an impact on carcass characteristics.	Arginine	73-81	leptin	Bos taurus	49-55
22883364-7	2012	Children exposed to mildewy odor with ADRB2 Arg/Arg genotype were associated with being awakened at night due to wheezing (OR=1.95, 95% CI, 1.14-3.36), compared to those without exposure and with the ADRB2 Gly allele.	Arginine	44-47	adrenoceptor beta 2	Homo sapiens	38-43
22883364-7	2012	Children exposed to mildewy odor with ADRB2 Arg/Arg genotype were associated with being awakened at night due to wheezing (OR=1.95, 95% CI, 1.14-3.36), compared to those without exposure and with the ADRB2 Gly allele.	Arginine	44-47	adrenoceptor beta 2	Homo sapiens	200-205
22883364-7	2012	Children exposed to mildewy odor with ADRB2 Arg/Arg genotype were associated with being awakened at night due to wheezing (OR=1.95, 95% CI, 1.14-3.36), compared to those without exposure and with the ADRB2 Gly allele.	Arginine	48-51	adrenoceptor beta 2	Homo sapiens	38-43
22883364-7	2012	Children exposed to mildewy odor with ADRB2 Arg/Arg genotype were associated with being awakened at night due to wheezing (OR=1.95, 95% CI, 1.14-3.36), compared to those without exposure and with the ADRB2 Gly allele.	Arginine	48-51	adrenoceptor beta 2	Homo sapiens	200-205
22883364-9	2012	Frequency and degree of home dampness were also associated with the prevalence of asthma and selected indicators of severity of asthma, in an exposure-response manner among children with ADRB2 Arg/Arg genotype.	Arginine	193-196	adrenoceptor beta 2	Homo sapiens	187-192
22883364-9	2012	Frequency and degree of home dampness were also associated with the prevalence of asthma and selected indicators of severity of asthma, in an exposure-response manner among children with ADRB2 Arg/Arg genotype.	Arginine	197-200	adrenoceptor beta 2	Homo sapiens	187-192
22883364-10	2012	CONCLUSIONS: Home dampness prevention is one of the important steps of asthma control, especially in children carrying ADRB2 Arg/Arg genotypes.	Arginine	125-128	adrenoceptor beta 2	Homo sapiens	119-124
22456434-1	2012	BACKGROUND/AIMS: We conducted a case-control study in China to clarify the association between XRCC1-Arg-399Gin polymorphism and HCC risk.	Arginine	101-104	X-ray repair cross complementing 1	Homo sapiens	95-100
22456434-8	2012	Individuals carrying XRCC1 Gin/Gin genotypes showed significantly lower median survival than XRCC1 Arg/ Arg genotypes and significant hazard ratio (HR=l.38, 95% CI=l.04-1.84) was found.	Arginine	99-102	X-ray repair cross complementing 1	Homo sapiens	93-98
22532369-3	2012	Previously, it was demonstrated that protein arginine methyltransferase 1 (PRMT1)-dependent arginine modification of FoxO1 interferes with Akt-dependent phosphorylation, both in cancer cells and in the Caenorhabditis elegans model, suggesting that this additional modification of FoxO1 might be critical in its transcriptional activity.	Arginine	45-53	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	75-80
22976420-10	2012	Immunomodulating diets (IMDs) containing supplemental arginine and omega-3 fatty acids have been demonstrated to restore the Th1/Th2 balance after surgical trauma and to reduce the risk of infectious complications.	Arginine	54-62	negative elongation factor complex member C/D	Homo sapiens	125-128
22986341-1	2012	A Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1 was localized by structure-guided arginine-scanning mutagenesis in combination with surface plasmon resonance assays.	Arginine	98-106	WNT inhibitory factor 1	Homo sapiens	40-63
22843728-9	2012	Arg(262) on TM7, which apparently mimics the role of Na(+) in CaiT structural homologues, plays a key role in triggering the dissociation of the substrate away from the primary site and guiding its release to the cytoplasm provided that the unwound part of TM3 switches from a shielding to a yielding pose.	Arginine	0-3	tropomyosin 3	Homo sapiens	257-260
22565339-7	2012	However, combination of these two gene polymorphisms (XRCC1-280 Arg and hOGG1-326Cys) is associated with significant induction of HCC risk.	Arginine	64-67	X-ray repair cross complementing 1	Homo sapiens	54-59
22705145-4	2012	Uptake of ADMA and l-arginine were significantly (p&lt;0.001) higher in HEK-CAT1 than in HEK-VC at all investigated concentrations.	Arginine	19-29	solute carrier family 7 member 1	Homo sapiens	76-80
22705145-5	2012	Apparent V(max) values of cellular ADMA and l-arginine uptake by CAT1 were 26.9 +- 0.8 and 11.0 +- 0.2 nmol mg protein(-1) min(-1), respectively.	Arginine	44-54	solute carrier family 7 member 1	Homo sapiens	65-69
22705145-8	2012	ADMA and SDMA inhibited CAT1-mediated uptake of l-arginine with IC(50) values of 758 (460-1251) mumoll(-1) and 789 (481-1295) mumoll(-1), respectively.	Arginine	48-58	solute carrier family 7 member 1	Homo sapiens	24-28
22705145-11	2012	In its physiological concentration range ADMA is unlikely to impair CAT1-mediated transport of l-arginine.	Arginine	95-105	solute carrier family 7 member 1	Homo sapiens	68-72
22705145-12	2012	Conversely, high (but still physiological) concentrations of l-arginine can inhibit CAT1-mediated cellular uptake of ADMA.	Arginine	61-71	solute carrier family 7 member 1	Homo sapiens	84-88
22945436-0	2012	Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.	Arginine	44-47	cholecystokinin	Rattus norvegicus	6-9
22849492-0	2012	Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin.	Arginine	0-3	cortactin	Homo sapiens	64-73
22849492-4	2012	We employ actin cosedimentation assays to show that Arg increases the stoichiometry of binding of cortactin to F-actin at saturation.	Arginine	52-55	cortactin	Homo sapiens	98-107
22849492-5	2012	Using a series of Arg deletion mutants and fragments, we demonstrate that the Arg C-terminal calponin homology domain is necessary and sufficient to increase the stoichiometry of binding of cortactin to F-actin.	Arginine	18-21	cortactin	Homo sapiens	190-199
22849492-5	2012	Using a series of Arg deletion mutants and fragments, we demonstrate that the Arg C-terminal calponin homology domain is necessary and sufficient to increase the stoichiometry of binding of cortactin to F-actin.	Arginine	78-81	cortactin	Homo sapiens	190-199
22849492-6	2012	We also show that interactions between Arg and cortactin are required for optimal affinity between cortactin and the actin filament.	Arginine	39-42	cortactin	Homo sapiens	47-56
22849492-6	2012	We also show that interactions between Arg and cortactin are required for optimal affinity between cortactin and the actin filament.	Arginine	39-42	cortactin	Homo sapiens	99-108
22849492-7	2012	Our data suggest a mechanism for Arg-dependent stimulation of binding of cortactin to F-actin, which may facilitate the recruitment of cortactin to sites of local actin network assembly.	Arginine	33-36	cortactin	Homo sapiens	73-82
22849492-7	2012	Our data suggest a mechanism for Arg-dependent stimulation of binding of cortactin to F-actin, which may facilitate the recruitment of cortactin to sites of local actin network assembly.	Arginine	33-36	cortactin	Homo sapiens	135-144
22083526-5	2012	In addition, purified CD11b(+) cells obtained from the spleen of CpG-ODN+IFA-treated mice exhibited increased ARG activity and ARG I expression along with an augmented [(3)H]-L-arginine uptake.	Arginine	175-185	integrin subunit alpha M	Homo sapiens	22-27
22667467-4	2012	In this work, pulsed electron-nuclear double resonance (ENDOR) was used to probe the position of the l-Arg substrate at the NO( )-coordinated ferrous heme center(s) in the oxygenase domain of rat neuronal NOS (nNOS).	Arginine	101-106	nitric oxide synthase 1	Rattus norvegicus	196-208
22667467-4	2012	In this work, pulsed electron-nuclear double resonance (ENDOR) was used to probe the position of the l-Arg substrate at the NO( )-coordinated ferrous heme center(s) in the oxygenase domain of rat neuronal NOS (nNOS).	Arginine	101-106	nitric oxide synthase 1	Rattus norvegicus	210-214
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Arginine	71-79	glucagon	Rattus norvegicus	127-132
22495587-11	2012	L-amino acids phenylalanine (Phe), tryptophan (Trp), asparagine (Asn), arginine (Arg) and glutamine (Gln) also stimulated GIP, GLP-1 and PYY secretion, which was completely abolished when extracellular Ca2+ was absent.	Arginine	81-84	glucagon	Rattus norvegicus	127-132
22572614-7	2012	The administration of L-Arg promoted the synthesis of NO and significantly elevated the expressions of VEGF, eNOS and PTC density with the conspicuous loss of HIF-1alpha and TGF-beta1 expressions and ultimately ameliorated renal fibrosis, which was markedly aggravated by L-NAME administration.	Arginine	22-27	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	159-169
22549777-6	2012	In addition, mutation of these two lysines into arginine residues significantly increases GLI2 transcriptional activity in a cell-based reporter assay.	Arginine	48-56	GLI-Kruppel family member GLI2	Mus musculus	90-94
21638020-11	2012	In conclusion, this study demonstrated that dietary Arg or NCG supplementation may affect microRNAs (miR-15b, miR-222) targeting VEGFA and eNOS gene expressions in umbilical vein, so as to regulate the function and volume of the umbilical vein, provide more nutrients and oxygen from the maternal to the fetus tissue for fetal development and survival, and enhance the reproductive performance of sows.	Arginine	52-55	microRNA 15b	Homo sapiens	101-108
22182949-5	2012	Arginase I and II protein levels reached a maximum between 0.25 and 0.5 mM Arg in controls; in macrophages from ZDF rats arginase I was significantly lower and progressively increased up to 2 mM Arg while arginase II was not affected by Arg concentration.	Arginine	0-3	arginase 2	Rattus norvegicus	205-216
22182949-5	2012	Arginase I and II protein levels reached a maximum between 0.25 and 0.5 mM Arg in controls; in macrophages from ZDF rats arginase I was significantly lower and progressively increased up to 2 mM Arg while arginase II was not affected by Arg concentration.	Arginine	75-78	arginase 2	Rattus norvegicus	0-17
22182949-5	2012	Arginase I and II protein levels reached a maximum between 0.25 and 0.5 mM Arg in controls; in macrophages from ZDF rats arginase I was significantly lower and progressively increased up to 2 mM Arg while arginase II was not affected by Arg concentration.	Arginine	75-78	arginase 2	Rattus norvegicus	0-17
21972075-6	2012	Patient showed homozygous mutation in exon 9 of GLUT2 gene 1093 C&gt;T, the mutation causing transition from arginine to stop codon at position 365 and causing premature termination of protein.	Arginine	109-117	solute carrier family 2 member 2	Homo sapiens	48-53
22649803-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
22649804-19	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
22467876-0	2012	Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).	Arginine	35-43	microtubule associated protein RP/EB family member 1	Homo sapiens	151-172
22467876-0	2012	Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1).	Arginine	35-43	microtubule associated protein RP/EB family member 1	Homo sapiens	174-177
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Arginine	138-146	microtubule associated protein RP/EB family member 1	Homo sapiens	51-54
22467876-6	2012	By employing molecular dynamics simulations of the EB1 interaction with a minimal CLASP2 plus-end-tracking module, we find that conserved arginine residues in CLASP2 form extensive hydrogen-bond networks with glutamate residues predominantly in the unstructured, acidic C-terminal tail of EB1.	Arginine	138-146	microtubule associated protein RP/EB family member 1	Homo sapiens	289-292
22411985-6	2012	Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR   A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4).	Arginine	54-62	F2R like thrombin or trypsin receptor 3	Homo sapiens	16-22
22411985-6	2012	Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR   A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4).	Arginine	54-62	retinoid X receptor alpha	Homo sapiens	70-73
22411985-6	2012	Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR   A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4).	Arginine	54-62	F2R like thrombin or trypsin receptor 3	Homo sapiens	213-219
22396535-7	2012	SIGLEC1 Ig domain shares ~22% sequence identity with PILRalpha, an identity that includes a conserved arginine localized to position 97 in mouse and human SIGLEC1, position 133 in mouse PILRalpha and position 126 in human PILRalpha.	Arginine	102-110	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-7
22396535-7	2012	SIGLEC1 Ig domain shares ~22% sequence identity with PILRalpha, an identity that includes a conserved arginine localized to position 97 in mouse and human SIGLEC1, position 133 in mouse PILRalpha and position 126 in human PILRalpha.	Arginine	102-110	paired immunoglobin-like type 2 receptor alpha	Mus musculus	53-62
22396535-8	2012	We observe that PILRalpha/ligand interactions require conserved PILRalpha Arg-133 (mouse) and Arg-126 (human), in correspondence with a previously reported requirement for SIGLEC1 Arg-197 in SIGLEC1/ligand interactions.	Arginine	74-77	paired immunoglobin-like type 2 receptor alpha	Mus musculus	16-25
22396535-8	2012	We observe that PILRalpha/ligand interactions require conserved PILRalpha Arg-133 (mouse) and Arg-126 (human), in correspondence with a previously reported requirement for SIGLEC1 Arg-197 in SIGLEC1/ligand interactions.	Arginine	74-77	paired immunoglobin-like type 2 receptor alpha	Mus musculus	64-73
22396535-8	2012	We observe that PILRalpha/ligand interactions require conserved PILRalpha Arg-133 (mouse) and Arg-126 (human), in correspondence with a previously reported requirement for SIGLEC1 Arg-197 in SIGLEC1/ligand interactions.	Arginine	94-97	paired immunoglobin-like type 2 receptor alpha	Mus musculus	16-25
22396535-8	2012	We observe that PILRalpha/ligand interactions require conserved PILRalpha Arg-133 (mouse) and Arg-126 (human), in correspondence with a previously reported requirement for SIGLEC1 Arg-197 in SIGLEC1/ligand interactions.	Arginine	94-97	paired immunoglobin-like type 2 receptor alpha	Mus musculus	16-25
22095282-0	2012	Arginine methylation-dependent regulation of ASK1 signaling by PRMT1.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	63-68
22095282-3	2012	We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling.	Arginine	81-89	protein arginine methyltransferase 1	Homo sapiens	17-22
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Arginine	156-165	protein arginine methyltransferase 1	Homo sapiens	0-5
22095282-4	2012	PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimulation of ASK1, with this inhibitory effect of PRMT1 being abolished by replacement of arginines 78 and 80 of ASK1 with lysine.	Arginine	156-165	protein arginine methyltransferase 1	Homo sapiens	116-121
22095282-8	2012	Together, our results indicate that arginine methylation of ASK1 by PRMT1 contributes to the regulation of stress-induced signaling that controls a variety of cellular events including apoptosis.	Arginine	36-44	protein arginine methyltransferase 1	Homo sapiens	68-73
22241104-3	2012	Argininosuccinate lyase (ASL) catalyzes the fourth reaction in this cycle, resulting in the breakdown of argininosuccinic acid to arginine and fumarate.	Arginine	130-138	argininosuccinate lyase	Homo sapiens	0-23
22241104-3	2012	Argininosuccinate lyase (ASL) catalyzes the fourth reaction in this cycle, resulting in the breakdown of argininosuccinic acid to arginine and fumarate.	Arginine	130-138	argininosuccinate lyase	Homo sapiens	25-28
22496563-7	2012	The major sites of AChRalpha ubiquitination reside within the large intracellular loop and mutations of critical lysine residues in this loop to arginine increased AChRalpha stability in the absence of alphakap.	Arginine	145-153	cholinergic receptor nicotinic alpha 1 subunit	Homo sapiens	164-173
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	0-8	argininosuccinate lyase	Homo sapiens	76-99
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	0-8	argininosuccinate lyase	Homo sapiens	101-104
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	0-8	glycine-N-acyltransferase	Homo sapiens	218-253
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	0-8	glycine-N-acyltransferase	Homo sapiens	255-258
22240035-6	2012	A total of five out of six histidine residues located within the E2 RBD (receptor-binding domain) were important for the E2 fold, and their substitution with arginine or alanine caused aberrant heterodimerization and/or CD81 binding.	Arginine	158-166	CD81 molecule	Homo sapiens	220-224
22305799-9	2012	Arg acted downstream of receptor tyrosine kinases to regulate phosphorylation of endogenous CrkII and paxillin, adaptor proteins involved in activation of Rho family GTPases and actin reorganization.	Arginine	0-3	v-crk avian sarcoma virus CT10 oncogene homolog S homeolog	Xenopus laevis	92-97
22084859-0	2012	XRCC1 399 Arg-related genotype and allele, but not XRCC1 His107Arg, XRCC1 Trp194Arg, KCNQ2, AT1R, and hOGG1 polymorphisms, are associated with higher susceptibility of endometriosis.	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	0-5
22248664-11	2012	Induction of acute pancreatitis by L-arginine required induction of macrophage migration by CCL2, via the receptor CCR2.	Arginine	35-45	chemokine (C-C motif) ligand 2	Mus musculus	92-96
22537951-9	2012	The Arg allele frequency of the polymorphisms of UGT1A1 gene in the case group was significantly higher than in the control group (P&lt;0.01).	Arginine	4-7	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-55
22654866-10	2012	Taken together, our results demonstrate that the C2 Arg residue in BomPBAN is essential for PBANR binding and activation.	Arginine	52-55	pheromone biosynthesis activating neuropeptide receptor	Bombyx mori	92-97
22279135-11	2012	In conclusion, our results demonstrate that the beneficial effect of dietary L-arginine supplementation on mammalian reproduction is associated with enhanced Vegfr2 transcription activity in fetoplacental tissues.	Arginine	77-87	kinase insert domain receptor	Homo sapiens	158-164
21948185-2	2012	The objective of this study was to determine the influence of short-term supplementation with L-arginine in stress conditions, induced by ischemia-reperfusion syndrome, by assessing the damage to muscular and hepatic cells on the basis of creatine kinase (CK), alanine aminotransferase (ALAT) and aspartic aminotransferase (AspAT) activity in blood and the level of oxygen free radicals in analyzed tissues of rats.	Arginine	94-104	glutamic--pyruvic transaminase	Rattus norvegicus	261-285
21948185-2	2012	The objective of this study was to determine the influence of short-term supplementation with L-arginine in stress conditions, induced by ischemia-reperfusion syndrome, by assessing the damage to muscular and hepatic cells on the basis of creatine kinase (CK), alanine aminotransferase (ALAT) and aspartic aminotransferase (AspAT) activity in blood and the level of oxygen free radicals in analyzed tissues of rats.	Arginine	94-104	glutamic--pyruvic transaminase	Rattus norvegicus	287-291
22038625-2	2012	In the current study, we investigated the mechanism by which arginine inhibited PPARgamma in vitro in rat small bowel epithelial IEC-6 cells.	Arginine	61-69	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	80-89
22038625-3	2012	Arginine repressed PPARgamma transcriptional activity in a time and dose-dependent fashion.	Arginine	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	19-28
22038625-4	2012	Furthermore, downregulation of PPARgamma by arginine involved phosphorylation of c-Jun that occurred before to changes in PPARgamma transcriptional activity.	Arginine	44-52	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	31-40
22038625-4	2012	Furthermore, downregulation of PPARgamma by arginine involved phosphorylation of c-Jun that occurred before to changes in PPARgamma transcriptional activity.	Arginine	44-52	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	122-131
22038625-7	2012	In conclusion, arginine decreased PPARgamma transcriptional activity in small bowel intestinal epithelial cells.	Arginine	15-23	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	34-43
22396406-5	2012	In contrast, dendritic spines in mice lacking Arg destabilized by P31, leading to a net loss in both structures.	Arginine	46-49	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	Mus musculus	66-69
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Arginine	21-24	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Arginine	203-206	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21895720-7	2012	RESULTS: The ADH1B 47Arg allele was found to be associated with increased risk of UADT cancers, the pooled odds ratios (ORs) being 1.66 (95% CI: 1.54 to 1.79) and 3.47 (95% CI: 2.76 to 4.36) for the His/Arg and Arg/Arg genotypes compared with the His/His genotype, respectively.	Arginine	203-206	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21814794-4	2012	The current work studies the cooperation between the cardiac polyamines and L-arginine (L-Arg) availability in MHC-ODC mice.	Arginine	76-86	ornithine decarboxylase, structural 1	Mus musculus	115-118
21814794-4	2012	The current work studies the cooperation between the cardiac polyamines and L-arginine (L-Arg) availability in MHC-ODC mice.	Arginine	88-93	ornithine decarboxylase, structural 1	Mus musculus	115-118
21814794-5	2012	Although ISO-induced hypertrophy is well-compensated, MHC-ODC mice administered L-Arg along with ISO showed a rapid onset of systolic dysfunction and died within 48 h. Myocytes isolated from MHC-ODC mice administered L-Arg/ISO exhibited reduced contractility and altered calcium transients, suggesting an alteration in [Ca(2+)] homeostasis, and abbreviated action potential duration, which may contribute to arrhythmogenesis.	Arginine	80-85	ornithine decarboxylase, structural 1	Mus musculus	58-61
21814794-5	2012	Although ISO-induced hypertrophy is well-compensated, MHC-ODC mice administered L-Arg along with ISO showed a rapid onset of systolic dysfunction and died within 48 h. Myocytes isolated from MHC-ODC mice administered L-Arg/ISO exhibited reduced contractility and altered calcium transients, suggesting an alteration in [Ca(2+)] homeostasis, and abbreviated action potential duration, which may contribute to arrhythmogenesis.	Arginine	80-85	ornithine decarboxylase, structural 1	Mus musculus	195-198
21814794-5	2012	Although ISO-induced hypertrophy is well-compensated, MHC-ODC mice administered L-Arg along with ISO showed a rapid onset of systolic dysfunction and died within 48 h. Myocytes isolated from MHC-ODC mice administered L-Arg/ISO exhibited reduced contractility and altered calcium transients, suggesting an alteration in [Ca(2+)] homeostasis, and abbreviated action potential duration, which may contribute to arrhythmogenesis.	Arginine	80-85	Rho guanine nucleotide exchange factor (GEF) 12	Mus musculus	217-226
21814794-9	2012	Further, NO generated by exogenously supplied L-Arg may contribute to the lethal consequences of L-Arg/ISO treatment.	Arginine	46-51	Rho guanine nucleotide exchange factor (GEF) 12	Mus musculus	97-106
21882174-5	2012	It was found that of human ferritin light chain, bacterial arginine deiminase, human granulocyte colony stimulating factor were synthesized evidently with the self-assembly function, L-arginine-degrading activity, and the correct secondary structure, respectively, through the fusion expression using N-ePGK.	Arginine	183-193	ferritin light chain	Homo sapiens	27-47
22127368-7	2012	The Arg/Arg carriers had higher cancer grade and higher TNM stage.	Arginine	4-7	teneurin transmembrane protein 1	Homo sapiens	56-59
22127368-7	2012	The Arg/Arg carriers had higher cancer grade and higher TNM stage.	Arginine	8-11	teneurin transmembrane protein 1	Homo sapiens	56-59
2699104-7	1989	Alternatively, porcine pancreastatin rather stimulated insulin release during arginine infusion or following theophylline administration.	Arginine	78-86	insulin	Canis lupus familiaris	55-62
2753902-1	1989	The platelet glycoprotein IIb-IIIa complex (GP IIb-IIIa) is a member of the integrin receptor family that recognizes adhesive proteins containing the Arg-Gly-Asp (RGD) sequence.	Arginine	150-153	integrin subunit alpha 2b	Homo sapiens	44-50
20641959-20	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	130-141
2478197-6	1989	The proximity of Tyr and Arg to the epitope was suggested by the lack of 2B1B1 binding to iodinated OSCP and by the susceptibility of this binding to trypsin or to endoproteinase Arg-C treatments of OSCP, respectively.	Arginine	25-28	ATP synthase peripheral stalk subunit OSCP	Homo sapiens	199-203
22901183-8	2012	CONCLUSIONS: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	13-18
2545724-4	1989	Mutant proteins containing Leu, Arg, Met, or Pro at residue 175 of mature CCP were sensitive to proteolysis and were imported into isolated mitochondria as judged by proteolytic processing of the precursor.	Arginine	32-35	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	74-77
23464416-6	2012	The XRCC1 Arg399Gln variant allele was associated with mixed acute and late adverse reactions when studies on late toxicity only were excluded [Gln allele vs. Arg allele: OR, 1.22; 95% CI, 1.00-1.49].	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	4-9
23464416-7	2012	In contrast, the XRCC1 Arg280His variant allele was protective against radiation-induced toxicity in studies including patients treated by radiotherapy alone [His allele vs. Arg allele: OR, 0.58; 95% CI, 0.35-0.96].	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	17-22
23741747-2	2012	Using the complete set of 23 Tudor proteins from Drosophila, together with the available functional information, we propose a putative link for different types of Tudor domains (histone-binding, SMN and SND1) and the four functional groups of Tudor proteins (Group 1, binding the methyl-lysine / arginine of histone tails; Group 2, binding the methyl-RG / RA box of ligand; Group 3, binding the methyl-RG /RA box of microRNPs; and Group 4, binding the methyl-RG /RA box of PIWI proteins).	Arginine	296-304	anon-86Ca	Drosophila melanogaster	259-266
2542324-10	1989	Since chicken AK1 is highly homologous to human AK1 with respect to the amino acid sequence, we introduced an Arg to Trp substitution to chicken AK1 at the same position by oligodeoxynucleotide-directed mutagenesis.	Arginine	110-113	adenylate kinase 1	Gallus gallus	14-17
2542324-10	1989	Since chicken AK1 is highly homologous to human AK1 with respect to the amino acid sequence, we introduced an Arg to Trp substitution to chicken AK1 at the same position by oligodeoxynucleotide-directed mutagenesis.	Arginine	110-113	adenylate kinase 1	Gallus gallus	48-51
23430891-4	2012	The 677C T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was analyzed by PCR.Case 1 presented severe hyperhomocysteinemia (81 mumol/L; control values &lt;10.8) 3 months after Gly/Arg therapy.	Arginine	202-205	methylenetetrahydrofolate reductase	Homo sapiens	31-66
2768221-2	1989	The result has given experimental support to the mechanisms previously proposed by the authors for the selective inhibition of trypsin, thrombin, factor Xa, and plasmin by inhibitors with an arginine or lysine backbone.	Arginine	191-199	coagulation factor X	Homo sapiens	146-155
22911765-8	2012	Further, ChIP analysis of two of the most highly up- and down-regulated genes (PTN and MAGEA12, respectively) found that PAD2 binds directly to these gene promoters and that the likely mechanism by which PAD2 regulates expression of these genes is via citrullination of arginine residues 2-8-17 on histone H3 tails.	Arginine	270-278	peptidyl arginine deiminase 2	Homo sapiens	121-125
22911765-8	2012	Further, ChIP analysis of two of the most highly up- and down-regulated genes (PTN and MAGEA12, respectively) found that PAD2 binds directly to these gene promoters and that the likely mechanism by which PAD2 regulates expression of these genes is via citrullination of arginine residues 2-8-17 on histone H3 tails.	Arginine	270-278	peptidyl arginine deiminase 2	Homo sapiens	204-208
2713490-2	1989	We have examined the role of the two chains of GPIIb in the maintenance of the GPIIb-IIIa heterodimer and Arg-Gly-Asp (RGD) peptide-binding function.	Arginine	106-109	integrin subunit alpha 2b	Homo sapiens	47-52
21964458-12	2012	The structure of ReP1-NCXSQ predicted from the amino acid sequence has been confirmed by X-ray crystal analysis; it has a "barrel" formed by ten beta sheets and two alpha helices, with a lipid coordinated by hydrogen bonds with Arg 126 and Tyr 128.	Arginine	228-231	CHM Rab escort protein	Homo sapiens	17-21
2497225-4	1989	The stable products of the L-arginine pathway, NO2- and NO3-, were incapable of causing cytostasis under coculture conditions.	Arginine	27-37	NBL1, DAN family BMP antagonist	Mus musculus	56-59
2708912-8	1989	It is shown in addition that the tripeptide Arg-Gly-Asp, identical to the region of iC3b recognized by CR3 and by several adhesion-promoting receptors that are structurally similar to CR3, such as fibronectin or vitronectin, is a significant inhibitor of the binding to and the phagocytosis of S-RBC by monocytic-macrophagic cells.	Arginine	44-47	vitronectin	Homo sapiens	212-223
2742827-2	1989	At pH 5.3 and 25 degrees C, the Arg(16)-Gly(17) peptide bonds in both F6 and F8 were cleaved instantaneously in the presence of 0.5 mM thrombin, producing truncated peptides tF6 and tF8 and other peptide fragments.	Arginine	32-35	trafficking from ER to golgi regulator	Homo sapiens	174-177
2466844-13	1989	Since the substitution of citrulline for Arg would generate several relatively long apolar sequences, these would enhance the ability of C-8 to interact with the hydrophobic lipophilin molecule, promoting vesicle aggregation by hydrophobic interactions.	Arginine	41-44	proteolipid protein 1	Homo sapiens	174-184
2564394-0	1989	Characterization of an endoprotease from rat small intestinal mucosal secretory granules which generates somatostatin-28 from prosomatostatin by cleavage after a single arginine residue.	Arginine	169-177	somatostatin	Homo sapiens	105-120
2923370-7	1989	An increased HA production can possibly be mediated, directly or indirectly, by activated complement components, since a significant relationship was seen between increased plasma concentrations of C3a des Arg and BAL fluid HA (r = 0.61; p less than 0.05).	Arginine	206-209	complement C3	Homo sapiens	198-201
2784476-1	1989	L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and microbes.	Arginine	0-10	NBL1, DAN family BMP antagonist	Mus musculus	62-65
2784476-9	1989	Production of the vasorelaxant was enhanced by 0.5 mM L-arginine and inhibited reversibly by NG-methylated L-arginine analogs that block macrophage NO2-/NO3- synthesis.	Arginine	107-117	NBL1, DAN family BMP antagonist	Mus musculus	153-156
2784476-15	1989	and/or a closely related, highly reactive nitrogen oxide such as NO2, during their conversion of L-arginine to NO2-/NO3-.	Arginine	97-107	NBL1, DAN family BMP antagonist	Mus musculus	116-119
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Arginine	55-58	kallikrein related peptidase 4	Homo sapiens	39-49
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Arginine	55-58	kallikrein related peptidase 4	Homo sapiens	150-160
2920007-1	1989	We have proposed previously that the steps in coagulation most sensitive to inhibition by heparin are the thrombin-dependent amplification reactions, and that prothrombinase is formed in heparinized plasma only after Factor Xa activates Factor VIII and Factor V. These propositions were based on the demonstration that both heparin and Phe-Pro-Arg-CH2Cl completely inhibited 125I-prothrombin activation for up to 60 s when contact-activated plasma (CAP) was replenished with Ca2+.	Arginine	344-347	coagulation factor X	Homo sapiens	159-173
2535976-5	1989	During an active CMV infection elevated C3d as well as elevated C3a des arg levels were found and not in the control group (P less than 0.01).	Arginine	72-75	complement C3	Homo sapiens	64-67
2489039-3	1989	Replacement of glutamine-312 of the peptide with arginine produced an analogue that was recognized by the T cell clone only in the context of DR4 Dw10; neither DR1 nor any of the other DR4 alleles could present this peptide to the clone.	Arginine	49-57	major histocompatibility complex, class II, DR beta 4	Homo sapiens	142-145
2462607-0	1989	CR3 (CD11b/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide.	Arginine	48-51	integrin subunit alpha M	Homo sapiens	5-10
2470110-1	1989	The disialogangliosides GD2 and GD3 play a major role in the ability of human melanoma cells to attach to Arg-Gly-Asp-containing substrates such as fibronectin and vitronectin, since pretreatment of these cells with monoclonal antibodies to the oligosaccharide of GD2 and GD3 can inhibit their attachment and spreading on such adhesive proteins.	Arginine	106-109	vitronectin	Homo sapiens	164-175
3238653-5	1988	These studies suggest that the glycoprotein IIb-IIIa complex on activated platelets may interact with vitronectin substrate through the Arg-Gly-Asp mechanism.	Arginine	136-139	vitronectin	Homo sapiens	102-113
3264556-9	1988	The Arg-Gly-Asp cell recognition sequence is present in one of the EGF-type repeats, and a synthetic peptide from the putative cell-binding site of entactin was found to promote the attachment of mouse mammary tumor cells.	Arginine	4-7	nidogen 1	Mus musculus	148-156
2972704-10	1988	Tryptic mapping of [3H]arginine-labeled N-terminal ANF-related material demonstrated the presence of all peptides consistent with the ANF-(1-98) structure, including ANF-(92-98).	Arginine	23-31	natriuretic peptide A	Rattus norvegicus	51-54
2972704-10	1988	Tryptic mapping of [3H]arginine-labeled N-terminal ANF-related material demonstrated the presence of all peptides consistent with the ANF-(1-98) structure, including ANF-(92-98).	Arginine	23-31	natriuretic peptide A	Rattus norvegicus	134-137
2972704-10	1988	Tryptic mapping of [3H]arginine-labeled N-terminal ANF-related material demonstrated the presence of all peptides consistent with the ANF-(1-98) structure, including ANF-(92-98).	Arginine	23-31	natriuretic peptide A	Rattus norvegicus	134-137
2902147-3	1988	The acute insulin response (AIR) to 2.5 g of arginine during this infusion of epinephrine was significantly higher (P less than 0.05) than in controls as were the acute glucagon response (AGR) (P less than 0.05) and the acute somatostatin response (ASLIR) (P less than 0.05).	Arginine	45-53	insulin	Canis lupus familiaris	10-17
3283237-4	1988	Scatchard analysis indicated that approximately 1200 binding sites for C3a exist per cell with an estimated Kd of 8 x 10(-10) M. Human C3a des Arg also binds to guinea pig platelets, but Scatchard analysis indicated that no specific binding occurred.	Arginine	143-146	complement C3	Homo sapiens	71-74
3283237-4	1988	Scatchard analysis indicated that approximately 1200 binding sites for C3a exist per cell with an estimated Kd of 8 x 10(-10) M. Human C3a des Arg also binds to guinea pig platelets, but Scatchard analysis indicated that no specific binding occurred.	Arginine	143-146	complement C3	Homo sapiens	135-138
3042483-0	1988	Oxytocin increases arginine-induced A and B cell secretion in normal man and in diabetic subjects.	Arginine	19-27	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
3042483-2	1988	In the present study we show that oxytocin is also able to increase arginine-induced glucagon and insulin secretion in healthy human beings.	Arginine	68-76	oxytocin/neurophysin I prepropeptide	Homo sapiens	34-42
3066674-5	1988	It was found that a significant proportion of human granulocyte-macrophage colony stimulating factor was degraded by the yeast KEX2 protease that was cleaving after the dibasic sequence Arg-Arg at positions 23-24 of the mature protein.	Arginine	186-189	kexin KEX2	Saccharomyces cerevisiae S288C	127-131
3066674-5	1988	It was found that a significant proportion of human granulocyte-macrophage colony stimulating factor was degraded by the yeast KEX2 protease that was cleaving after the dibasic sequence Arg-Arg at positions 23-24 of the mature protein.	Arginine	190-193	kexin KEX2	Saccharomyces cerevisiae S288C	127-131
2472003-5	1988	The sequence shared by the otherwise unrelated DR1 and DR4 haplotypes from residue 67 in the DR a chain that appears to confer susceptibility is Leu-X-X-Gln-Arg/Lys.	Arginine	157-160	major histocompatibility complex, class II, DR beta 4	Homo sapiens	55-58
3259355-4	1988	We found significant correlations between IL-1 and C3a des Arg, IL-1 and IC and C3a des Arg, and IC in Ps.A.	Arginine	59-62	complement C3	Homo sapiens	51-54
3259355-4	1988	We found significant correlations between IL-1 and C3a des Arg, IL-1 and IC and C3a des Arg, and IC in Ps.A.	Arginine	88-91	complement C3	Homo sapiens	80-83
2447074-0	1987	Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.	Arginine	45-48	vitronectin	Homo sapiens	121-132
3436063-2	1987	Urinary argininosuccinate was identified by two methods; its conversions to anhydride by boiling in an acidic solution and to arginine by the enzymatic action of argininosuccinate lyase.	Arginine	126-134	argininosuccinate lyase	Homo sapiens	162-185
3427058-8	1987	Quantitative analysis of sequencer results indicated that the residues in TnI that appeared to be most highly cross-linked to Cys-98 of TnC were Arg-108 and Pro-110, and to a lesser extent Arg-103 and Lys-107.	Arginine	145-148	tenascin	Oryctolagus cuniculus	136-139
3312190-10	1987	As seen from active site models, cathepsin B, in contrast to papain, contains a triad of charged groups near the thiolate-imidazolium ion pair which is composed of Glu-131, Arg-162, and Glu-205.	Arginine	173-176	cathepsin B	Homo sapiens	33-44
2437111-2	1987	Bovine NRP was identified as H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH, which is similar in structure to both neurotensin and angiotensin I. Canine and human NRP also had the above amino acid composition, whereas that obtained from rat plasma had valine substituted for isoleucine.	Arginine	39-42	neurotensin	Bos taurus	109-120
3039294-3	1987	Alignment of the enzyme sequence derived from URA2 with sequences from Escherichia coli carA carB and yeast arginine-specific CP A1 CP A2 indicates that monofunctional and bifunctional carbamoyl phosphate synthetases are probably homologous.	Arginine	108-116	bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase	Saccharomyces cerevisiae S288C	46-50
3593043-3	1987	Plasma C3a des arg values increased markedly in the dialyzer outflow blood with the three dialyzer configurations.	Arginine	15-18	complement C3	Homo sapiens	7-10
3566584-3	1987	All patients demonstrated transient complement activation immediately postoperatively, as indicated by an increase in plasma levels of C3a des Arg.	Arginine	143-146	complement C3	Homo sapiens	135-138
3566584-4	1987	In the two long-term survivors, C3a des Arg levels again increased, concomitant with intravascular hemolysis associated with high blood shear rates imposed by the drive system of the heart.	Arginine	40-43	complement C3	Homo sapiens	32-35
3105932-1	1987	The enzyme sequentially converts creatine kinase MM3 to MM2 and MM1 and hydrolyzes lysine and arginine from hippuryl-L-lysine and hippuryl-L-arginine.	Arginine	94-102	PNMA family member 2	Homo sapiens	56-59
3103124-0	1987	V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions.	Arginine	105-113	secreted Ly6/Plaur domain containing 1	Mus musculus	41-44
3103124-3	1987	An unusual feature of Ars-A light chains is that all contain an arginine at position 96, the V-J junctional position.	Arginine	64-72	secreted Ly6/Plaur domain containing 1	Mus musculus	22-25
3540604-7	1986	At base pair +683 a G-to-A transition was detected in the ADR1 coding sequence which would result in the substitution of a lysine residue for an arginine at amino acid 228.	Arginine	145-153	DNA-binding transcription factor ADR1	Saccharomyces cerevisiae S288C	58-62
2428041-8	1986	Vitronectin, another adhesion molecule that apparently binds to cells via a cell surface receptor that recognizes Arg-Gly-Asp sequences, also was capable of supporting trophoblast outgrowth.	Arginine	114-117	vitronectin	Mus musculus	0-11
3536894-4	1986	The complete prorenin sequence was then excised from the renatured hybrid protein using blood coagulation factor Xa, a proteinase which is highly specific for the tetrapeptide insert Ile-Glu-Gly-Arg introduced between the 9 amino-terminal residues of the trp E gene product and the first amino acid (Thr 1) of prorenin.	Arginine	195-198	coagulation factor X	Homo sapiens	106-115
3017908-1	1986	Viral oncogene product of avian sarcoma virus S2 was reported to have two alterations from proto-src product; a substitution of its extreme carboxyl terminus with a peptide of helper viral protein and a point mutation which altered the 501st amino acid from arginine to lysine.	Arginine	258-266	p60 src	Rous sarcoma virus	97-100
3009364-3	1986	Homology searches in protein data banks revealed the presence of the peptide SDGR in the alpha 2 domain of MHC class I antigens, and a variant of RGDS, Arg-Phe-Asp-Ser (RFDS), was found highly conserved in MHC class I (alpha 1 domain) and class II antigens (beta 1 domain).	Arginine	152-155	major histocompatibility complex, class I, C	Homo sapiens	206-209
22568010-2	2012	The Gln/Gln genotype of gene XRCC1 was associated with a significant increase in the number of chromosomal aberrations as compared to the corresponding homozygous wild type Arg/Arg (p &lt; 0.05).	Arginine	173-176	X-ray repair cross complementing 1	Homo sapiens	29-34
22568010-2	2012	The Gln/Gln genotype of gene XRCC1 was associated with a significant increase in the number of chromosomal aberrations as compared to the corresponding homozygous wild type Arg/Arg (p &lt; 0.05).	Arginine	177-180	X-ray repair cross complementing 1	Homo sapiens	29-34
2869632-0	1986	Somatostatin, insulin and glucagon after arginine stimulation in active and treated acromegaly.	Arginine	41-49	somatostatin	Homo sapiens	0-12
22730687-8	2012	The risks of lung cancer in smokers with XRCC1-194 Arg/Trp+Trp/Trp and XRCC1-280 His/His+Arg/His were 4.889 (95% CI: 2.828-8.452) and 6.281(95% CI: 3.572-11.046), respectively.	Arginine	51-54	X-ray repair cross complementing 1	Homo sapiens	41-46
2939067-3	1986	These two segments were isolated and chemically characterized after S-alkylation of the nicked protein S. The results suggest that the alpha-thrombin-catalyzed hydrolysis of protein S probably occurs at a peptide linkage (Arg-Ser) located in the NH2-terminal portion.	Arginine	222-225	coagulation factor II, thrombin	Bos taurus	141-149
21954455-0	2011	Temporal analysis of mRNA and miRNA expression in transgenic mice overexpressing Arg- and Gly389 polymorphic variants of the beta1-adrenergic receptor.	Arginine	81-84	adrenergic receptor, beta 1	Mus musculus	125-150
21954455-1	2011	Several studies in humans or transgenic animals have reported that the 389 Arg or Gly polymorphic variation of the beta1-adrenergic receptor (AR) is associated with differential responses to beta-blocker therapy and/or myocardial disease progression.	Arginine	75-78	adrenergic receptor, beta 1	Mus musculus	115-140
21954455-1	2011	Several studies in humans or transgenic animals have reported that the 389 Arg or Gly polymorphic variation of the beta1-adrenergic receptor (AR) is associated with differential responses to beta-blocker therapy and/or myocardial disease progression.	Arginine	75-78	adrenergic receptor, beta 1	Mus musculus	142-144
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Arginine	189-192	profilin	Saccharomyces cerevisiae S288C	38-46
21956104-1	2011	In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79).	Arginine	189-192	profilin	Saccharomyces cerevisiae S288C	153-161
21858719-5	2011	Sequence analysis identified a C3112T mutation in exon 18 of Sterol Regulatory Element Binding-Transcription Factor 2 (Srebf2) resulting in the R1038C substitution of a highly conserved arginine within the Srebf2 regulatory domain.	Arginine	186-194	sterol regulatory element binding factor 2	Mus musculus	61-117
21858719-5	2011	Sequence analysis identified a C3112T mutation in exon 18 of Sterol Regulatory Element Binding-Transcription Factor 2 (Srebf2) resulting in the R1038C substitution of a highly conserved arginine within the Srebf2 regulatory domain.	Arginine	186-194	sterol regulatory element binding factor 2	Mus musculus	119-125
21858719-5	2011	Sequence analysis identified a C3112T mutation in exon 18 of Sterol Regulatory Element Binding-Transcription Factor 2 (Srebf2) resulting in the R1038C substitution of a highly conserved arginine within the Srebf2 regulatory domain.	Arginine	186-194	sterol regulatory element binding factor 2	Mus musculus	206-212
22014686-3	2011	The vitamin D binding protein (DBP) has been shown to significantly enhance chemotaxis to C5a/C5a des Arg.	Arginine	102-105	GC vitamin D binding protein	Homo sapiens	4-29
22132964-5	2011	The corresponding mutations in GLUT1 (R153C and R333W) are known to cause GLUT1 deficiency syndrome because arginine residues in this motif are reportedly important as the determinants of the membrane topology of human GLUT1.	Arginine	108-116	solute carrier family 2 member 1	Homo sapiens	31-36
22132964-5	2011	The corresponding mutations in GLUT1 (R153C and R333W) are known to cause GLUT1 deficiency syndrome because arginine residues in this motif are reportedly important as the determinants of the membrane topology of human GLUT1.	Arginine	108-116	solute carrier family 2 member 1	Homo sapiens	74-79
22152690-9	2011	The objective response rate of the XRCC1 399 Arg/Arg genotype carriers was significantly higher than that of the patients with at least one Gln allele (45.5% vs 21.9%, OR=0.336, 95%CI: 0.156-0.722, P=0.005).	Arginine	45-48	X-ray repair cross complementing 1	Homo sapiens	35-40
22152690-9	2011	The objective response rate of the XRCC1 399 Arg/Arg genotype carriers was significantly higher than that of the patients with at least one Gln allele (45.5% vs 21.9%, OR=0.336, 95%CI: 0.156-0.722, P=0.005).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	35-40
22152690-13	2011	Patients with XRCC3 241 Thr/Met, 399 Arg/Arg, and at least one XRCC1 194 Trp allele simultaneously showed an improved objective response rate.	Arginine	37-40	X-ray repair cross complementing 3	Homo sapiens	14-19
21875681-1	2011	The production of nitric oxide (NO) from l-arginine is catalyzed by NO synthase (NOS), which exists as the following three isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	41-51	nitric oxide synthase 1	Rattus norvegicus	163-167
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Arginine	163-171	adrenoceptor beta 2	Homo sapiens	56-81
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Arginine	163-171	adrenoceptor beta 2	Homo sapiens	83-91
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Arginine	173-176	adrenoceptor beta 2	Homo sapiens	56-81
22048503-1	2011	BACKGROUND AND OBJECTIVES: Several polymorphisms of the beta2-adrenergic receptor (beta2-AR) gene have been identified, including the amino acid substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic acid (Glu) at codon 27.	Arginine	173-176	adrenoceptor beta 2	Homo sapiens	83-91
21507122-4	2011	Here, we have identified Arg-I(+) -MDSCs in the spinal cord during experimental autoimmune encephalomyelitis (EAE), cells that were largely restricted to the demyelinating plaque and that always exhibited the characteristic MDSC surface markers Arg-I/CD11b/Gr-1/M-CSF1R.	Arginine	25-28	integrin subunit alpha M	Homo sapiens	251-256
21846512-4	2011	Screening of a highly conserved arginine/serine (RS)-rich region in exon 9 of RBM20 was also performed.	Arginine	32-40	RNA binding motif protein 20	Homo sapiens	78-83
21822533-5	2011	siRNA-mediated reduction of fibronectin and interference in the liaison between fibronectin and integrins by the Arg-Gly-Asp-Ser (RGDS) peptide increased aggrecan expression, and decreased versican expression by TGF-beta1 stimulation.	Arginine	113-116	ral guanine nucleotide dissociation stimulator	Mus musculus	130-134
21302286-1	2011	Insulin causes endothelium-derived nitric oxide (NO)-dependent vascular relaxation, and increases L-arginine transport via cationic amino acid transporter 1 (hCAT-1) and endothelial NO synthase (eNOS) expression and activity in human umbilical vein endothelium (HUVEC).	Arginine	98-108	solute carrier family 7 member 1	Homo sapiens	158-164
21302286-12	2011	We suggest that insulin induces human umbilical vein relaxation by increasing HUVEC L-arginine transport via hCATs (likely hCAT-1) most likely requiring Sp1-activated SLC7A1 expression.	Arginine	84-94	solute carrier family 7 member 1	Homo sapiens	123-129
3484755-4	1986	In this report, we demonstrate that this variant protein also has greatly increased inhibitory activity towards the arginine-specific enzymes of the contact system of plasma proteolysis (Factor XIa, kallikrein, and Factor XIIf), in contrast to normal alpha 1-antitrypsin, which has modest to no inhibitory activity towards these enzymes.	Arginine	116-124	kallikrein related peptidase 4	Homo sapiens	199-209
2419513-1	1986	It has been proposed that the biochemical lesion in subacute combined degeneration of the cord due to vitamin B12 deficiency, is impaired methylation of residue 107 (arginine) in myelin basic protein.	Arginine	166-174	myelin basic protein	Rattus norvegicus	179-199
4055782-3	1985	The fragment begins at position 117 in pro-IGF-II, two amino acids downstream from an Arg-Arg potential prohormone processing site.	Arginine	86-89	insulin-like growth factor 2	Rattus norvegicus	43-49
4055782-3	1985	The fragment begins at position 117 in pro-IGF-II, two amino acids downstream from an Arg-Arg potential prohormone processing site.	Arginine	90-93	insulin-like growth factor 2	Rattus norvegicus	43-49
2414098-7	1985	An Arg-Gly-Asp sequence, which has previously been shown to be the cell attachment site in fibronectin, was found in vitronectin immediately after the NH2-terminal somatomedin B sequence.	Arginine	3-6	vitronectin	Homo sapiens	117-128
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Arginine	4-7	vitronectin	Homo sapiens	75-86
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Arginine	4-7	vitronectin	Homo sapiens	405-416
2412224-0	1985	A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin.	Arginine	80-88	vitronectin	Homo sapiens	49-60
3839186-5	1985	These 21-amino-acid peptides, termed PGLa, can be generated from PYLa by cleavage after the single arginine residue present in the latter.	Arginine	99-107	prepro-PGLa S homeolog	Xenopus laevis	37-41
3839186-5	1985	These 21-amino-acid peptides, termed PGLa, can be generated from PYLa by cleavage after the single arginine residue present in the latter.	Arginine	99-107	prepro-PGLa S homeolog	Xenopus laevis	65-69
3839186-7	1985	Tryptic hydrolysis of synthetic PYLa after the single arginine yields exclusively PGLa with the shorter retention time on HPLC.	Arginine	54-62	prepro-PGLa S homeolog	Xenopus laevis	32-36
3839186-7	1985	Tryptic hydrolysis of synthetic PYLa after the single arginine yields exclusively PGLa with the shorter retention time on HPLC.	Arginine	54-62	prepro-PGLa S homeolog	Xenopus laevis	82-86
4004871-1	1985	Tropoelastin and elastin preparations obtained from aortae of spontaneously hypertensive rats (SHR) show an increased proportion of polar amino acids (aspartic acid, glutamic acid, arginine and tyrosine).	Arginine	181-189	elastin	Rattus norvegicus	0-12
21862585-7	2011	We propose that when factor B first associates with C3b, it bears two intact Arg(234) salt bridges.	Arginine	77-80	complement C3	Homo sapiens	52-55
22408746-4	2011	IL-17 increased the suppressive function of MDSCs on T cells through the upregulation of Arg, IDO, and COX2.	Arginine	89-92	interleukin 17A	Homo sapiens	0-5
22038003-7	2011	Furthermore, compared with the addition of either myostatin protein or antibody alone, ADD1 and PPARdelta expression were promoted by the combination of arginine and myostatin (P&lt;0.01), and arginine combined with myostatin antibody promoted the expression of ADD1, PPARdelta, C/EBPalpha, PPARgamma2 and LPL in pMDSCs (P&lt;0.05).	Arginine	153-161	peroxisome proliferator activated receptor delta	Homo sapiens	96-105
22038003-7	2011	Furthermore, compared with the addition of either myostatin protein or antibody alone, ADD1 and PPARdelta expression were promoted by the combination of arginine and myostatin (P&lt;0.01), and arginine combined with myostatin antibody promoted the expression of ADD1, PPARdelta, C/EBPalpha, PPARgamma2 and LPL in pMDSCs (P&lt;0.05).	Arginine	193-201	peroxisome proliferator activated receptor delta	Homo sapiens	96-105
22038003-8	2011	These results suggest that myostatin inhibits adipogenesis in pMDSCs, and that this can be alleviated by arginine supplementation, at least in part, through promoting ADD1 and PPARdelta expression.	Arginine	105-113	peroxisome proliferator activated receptor delta	Homo sapiens	176-185
21820018-10	2011	Expectedly, site-directed mutagenesis of His321 in Lsc3 to Arg, Lys, Leu and Ser resulted in proteins with decreased catalytic activity, affinity for sucrose and polymerizing ability.	Arginine	59-62	glycoside hydrolase family 68 protein	Pseudomonas syringae pv. tomato str. DC3000	51-55
21875933-4	2011	The pro-MSP cleavage sequence (Ser-Lys-Leu-Arg(483) Val(484)) closely matches the substrate recognition sequences of hepsin, a type II transmembrane serine protease, that is overexpressed in several cancers.	Arginine	43-46	hepsin	Homo sapiens	117-123
21875933-5	2011	Here, we show that recombinant hepsin cleaves pro-MSP at the consensus site Arg(483)-Val(484) with superior efficiency compared with the known activators MT-SP1 and hepatocyte growth factor activator (HGFA).	Arginine	76-79	hepsin	Homo sapiens	31-37
21715329-10	2011	However, mutating a pair of conserved basic residues (equivalent to Arg-414 and Arg-415 of APLP1) immediately adjacent to the heparin binding site affects both the maturation and the processing of APP.	Arginine	80-83	amyloid beta precursor like protein 1	Homo sapiens	91-96
21558877-6	2011	Also, supplementation with the PPARgamma agonist pioglitazone or with l-arginine or hemin, substrates for NOS and HO, respectively, eliminated the unfavorable effect of CSA on isoprenaline vasodilations.	Arginine	70-80	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	31-40
21447361-3	2011	The cyclic RGD (Arg-Gly-Asp) peptide, a specific ligand with affinity for Integrin alpha(v)beta(3) was coupled to the distal end of the PEG on the PEG-LP (RGD-PEG-LP).	Arginine	16-19	integrin subunit alpha V	Homo sapiens	74-98
21602512-6	2011	RESULTS: CCK-KO mice fed a low-fat diet had a reduced acute insulin response to glucose but a normal response to arginine and normal glucose tolerance, associated with a trend toward greater insulin sensitivity.	Arginine	113-121	cholecystokinin	Mus musculus	9-12
21602512-7	2011	However, when fed a high-fat diet (HFD) for 10 weeks, CCK-KO mice developed glucose intolerance despite increased insulin sensitivity that was associated with low insulin secretion in response to both glucose and arginine.	Arginine	213-221	cholecystokinin	Mus musculus	54-57
21724836-1	2011	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	signal transducer and activator of transcription 1	Homo sapiens	55-60
21652632-0	2011	Arginine methylation of G3BP1 in response to Wnt3a regulates beta-catenin mRNA.	Arginine	0-8	G3BP stress granule assembly factor 1	Homo sapiens	24-29
21652632-4	2011	Mass spectrometry of a prominent arginine-methylated, Dishevelled-associated protein identified the Ras GTPase activating protein-binding protein 1 G3BP1.	Arginine	33-41	G3BP stress granule assembly factor 1	Homo sapiens	148-153
21652632-8	2011	Thus, the protein arginine methylation that targets G3BP1 acts as a novel regulator of Ctnnb1 mRNA.	Arginine	18-26	G3BP stress granule assembly factor 1	Homo sapiens	52-57
21527346-7	2011	One of the motifs contained Arg-229, which participates in interactions with the phosphate group of NADPH and appears be a determinant of the preferential binding of bFMO to NADPH rather than NADH.	Arginine	28-31	2,4-dienoyl-CoA reductase 1	Homo sapiens	100-105
21527346-7	2011	One of the motifs contained Arg-229, which participates in interactions with the phosphate group of NADPH and appears be a determinant of the preferential binding of bFMO to NADPH rather than NADH.	Arginine	28-31	2,4-dienoyl-CoA reductase 1	Homo sapiens	174-179
21735587-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
4004871-1	1985	Tropoelastin and elastin preparations obtained from aortae of spontaneously hypertensive rats (SHR) show an increased proportion of polar amino acids (aspartic acid, glutamic acid, arginine and tyrosine).	Arginine	181-189	elastin	Rattus norvegicus	5-12
21735593-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
3998120-1	1985	In an examination of arginine-utilizing Mycoplasma species, simple fluorogenic and chromogenic tests were used to demonstrate high levels of arginine aminopeptidase activity in unwashed, unconcentrated broth and agar cultures in all strains of 5 species and low levels of activity in all strains of 14 species.	Arginine	21-29	arginyl aminopeptidase	Homo sapiens	141-164
2986684-4	1985	The predicted amino acid sequence of mouse protamine 1 is about 80% homologous to boar protamine and 67% homologous to bull protamine and contains the central, highly basic domain of four arginine clusters found in the trout protamines.	Arginine	188-196	protamine 1	Mus musculus	43-54
21498885-4	2011	ARH1 also hydrolyzed OAADPr and poly(ADPr) as well as ADP-ribose-arginine, with arginine in alpha-anomeric linkage to C-1"" of ADP-ribose.	Arginine	65-73	ADP-ribosylarginine hydrolase	Homo sapiens	0-4
21498885-4	2011	ARH1 also hydrolyzed OAADPr and poly(ADPr) as well as ADP-ribose-arginine, with arginine in alpha-anomeric linkage to C-1"" of ADP-ribose.	Arginine	80-88	ADP-ribosylarginine hydrolase	Homo sapiens	0-4
6335699-5	1984	The C-terminal poly(arg) tail can be readily removed by treatment with carboxypeptidase B.	Arginine	20-23	carboxypeptidase B1	Homo sapiens	71-89
21498885-9	2011	ARH1 also hydrolyzed OAADPr more rapidly at alkaline pH, but cleavage of ADP-ribose-arginine was faster at neutral pH than pH 9.0.	Arginine	84-92	ADP-ribosylarginine hydrolase	Homo sapiens	0-4
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	47-50	ADAM metallopeptidase domain 17	Homo sapiens	146-152
21502321-0	2011	Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism.	Arginine	48-56	H4 clustered histone 9	Homo sapiens	0-10
6497161-2	1984	Levels of C3a des Arg and C5a des Arg were elevated in 35 and 38 patients, respectively, and in all 25 with positive blood cultures.	Arginine	18-21	complement C3	Homo sapiens	10-13
21294109-2	2011	Many of these comprise the exclusive combination of a classic, catalytic Arg-containing RhoGAP domain, and a Cdc42/ Rac interactive binding (CRIB) motif which in animal and fungi has been identified in effectors for Cdc42 and Rac1, but never in any GAP protein.	Arginine	73-76	Rac family small GTPase 1	Homo sapiens	226-230
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	116-124	kinesin family member 2C	Homo sapiens	82-104
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	116-124	kinesin family member 6	Homo sapiens	106-110
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	116-124	kinesin family member 6	Homo sapiens	225-229
6087320-9	1984	A search of the translated sequence of the 939-base-pair insert shows three regions beginning after arginine that have greater than 90% homology with the sequence determined from the calf thymus terminal transferase peptides.	Arginine	100-108	DNA nucleotidylexotransferase	Bos taurus	195-215
16663647-3	1984	Comparison of trichloroacetic acid (TCA)-soluble products derived from the hydrolysis of hemoglobin showed that carboxyterminal amino acids (histidine, arginine, and tyrosine), are released when extracts from wheat and barley endosperms are used.	Arginine	152-160	non-symbiotic hemoglobin	Zea mays	89-99
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	126-129	kinesin family member 2C	Homo sapiens	82-104
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	126-129	kinesin family member 6	Homo sapiens	106-110
21493817-1	2011	BACKGROUND: Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed.	Arginine	126-129	kinesin family member 6	Homo sapiens	225-229
6146518-0	1984	Effect of Ala-2-D-Trp-8-D-Cys-14-somatostatin on the arginine induced release of insulin, GH and glucagon in normal men.	Arginine	53-61	somatostatin	Homo sapiens	33-45
21458191-8	2011	Proportional reductions in the risk of major vascular events with statin therapy were similar (interaction p = 0.70) and highly significant across KIF6 genotypes: 23% (95% confidence interval: 16% to 29%; p = 5.3 x 10-10) in carriers (Arg/Arg or Trp/Arg), and 24% (95% confidence interval: 17% to 31%; p = 4.6 x 10-9) in noncarriers (Trp/Trp).	Arginine	235-238	kinesin family member 6	Homo sapiens	147-151
21458191-8	2011	Proportional reductions in the risk of major vascular events with statin therapy were similar (interaction p = 0.70) and highly significant across KIF6 genotypes: 23% (95% confidence interval: 16% to 29%; p = 5.3 x 10-10) in carriers (Arg/Arg or Trp/Arg), and 24% (95% confidence interval: 17% to 31%; p = 4.6 x 10-9) in noncarriers (Trp/Trp).	Arginine	239-242	kinesin family member 6	Homo sapiens	147-151
21458191-8	2011	Proportional reductions in the risk of major vascular events with statin therapy were similar (interaction p = 0.70) and highly significant across KIF6 genotypes: 23% (95% confidence interval: 16% to 29%; p = 5.3 x 10-10) in carriers (Arg/Arg or Trp/Arg), and 24% (95% confidence interval: 17% to 31%; p = 4.6 x 10-9) in noncarriers (Trp/Trp).	Arginine	239-242	kinesin family member 6	Homo sapiens	147-151
6146518-1	1984	The effects of several doses of somatostatin (SS) and the analog Ala-2-D-Trp-8-D-Cys-14-SS on the arginine-induced release of insulin, glucagon, and GH were compared in a group of normal human subjects.	Arginine	98-106	somatostatin	Homo sapiens	32-44
6644098-2	1983	Incubation of isolated epidermal cells with mM concentrations of glycine, asparagine, glutamic acid, canavanine, arginine, and/or lysine inhibited dramatically the induction of ornithine decarboxylase activity by the tumor promoter.	Arginine	113-121	ornithine decarboxylase, structural 1	Mus musculus	177-200
21595126-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
21595127-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
21595128-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
6644098-4	1983	Arginine and its analog, canavanine, inhibited to the same degree TPA-induced ornithine decarboxylase activity, and potentiated to the same extent the inhibitory effects of glutamic acid, asparagine, and glycine on this enzyme.	Arginine	0-8	ornithine decarboxylase, structural 1	Mus musculus	78-101
6688942-3	1983	The proposed sequence reveals a high content of basic amino acids (Arg and Lys) and Leu, is consistent with the amino acid composition, and predicts the correct number of peptides derived from tryptic digests reported for ligandin.	Arginine	67-70	glutathione S-transferase alpha 2	Rattus norvegicus	222-230
21490317-6	2011	CONCLUSIONS: Gating pore currents arising from missense mutations at arginine residues in the voltage sensor domains of Na(V)1.4 are a common feature of HypoPP mutant channels and contribute to the attacks of paralysis.	Arginine	69-77	immunoglobulin lambda variable 2-14	Homo sapiens	120-128
6137927-2	1983	Arginine administered at 30-60 min induced an increase in plasma glucose concentrations which was enhanced by SS-14 and further increased by SS-28.	Arginine	0-8	somatostatin	Homo sapiens	110-115
21780371-3	2011	The covalent bond between cyclic RGD (cRGD) containing an Arg-Gly-Asp sequence targeting integrin-alphavbeta3, and USPIO was conducted by chemical crosslinking.	Arginine	58-61	integrin subunit alpha V	Homo sapiens	89-109
6137927-2	1983	Arginine administered at 30-60 min induced an increase in plasma glucose concentrations which was enhanced by SS-14 and further increased by SS-28.	Arginine	0-8	somatostatin	Homo sapiens	141-146
6137927-3	1983	SS-28 was more effective than SS-14 in suppressing the arginine-induced secretion of insulin.	Arginine	55-63	somatostatin	Homo sapiens	0-5
21478268-6	2011	Wnt3a also increased the expression of a subset of endogenous Wnt target genes, and CARM1 was required for the Wnt-induced expression of these target genes and the accompanying dimethylation of arginine 17 of histone H3.	Arginine	194-202	coactivator associated arginine methyltransferase 1	Homo sapiens	84-89
6137927-3	1983	SS-28 was more effective than SS-14 in suppressing the arginine-induced secretion of insulin.	Arginine	55-63	somatostatin	Homo sapiens	30-35
6137927-4	1983	Arginine-stimulated and insulin-stimulated (at 120 min) glucagon release was equally suppressed by SS-14 and SS-28, as was insulin-stimulated pancreatic polypeptide secretion.	Arginine	0-8	somatostatin	Homo sapiens	99-104
21378158-3	2011	The MYO7A(G2164C) mutation predicts a nonconservative glycine-to-arginine (G722R) amino acid substitution at a highly conserved glycine residue.	Arginine	65-73	myosin VIIA	Homo sapiens	4-9
6137927-4	1983	Arginine-stimulated and insulin-stimulated (at 120 min) glucagon release was equally suppressed by SS-14 and SS-28, as was insulin-stimulated pancreatic polypeptide secretion.	Arginine	0-8	somatostatin	Homo sapiens	109-114
6840049-2	1983	The first aminopeptidase, which removes the N-terminal arginine residue from L-arginyl-L-prolyl-L-proline, bradykinin, and des-[Arg9]-bradykinin, has kininase activity; it has a pH optimum of 8.0, is stimulated by Mn2+, and its molecular weight in dilute buffers is slightly greater than 240,000 daltons.	Arginine	55-63	kininogen 1	Bos taurus	107-117
6840049-2	1983	The first aminopeptidase, which removes the N-terminal arginine residue from L-arginyl-L-prolyl-L-proline, bradykinin, and des-[Arg9]-bradykinin, has kininase activity; it has a pH optimum of 8.0, is stimulated by Mn2+, and its molecular weight in dilute buffers is slightly greater than 240,000 daltons.	Arginine	55-63	kininogen 1	Bos taurus	134-144
7161255-1	1982	Adrenodoxin reductase from bovine adrenocortex was inactivated by arginine specific reagents, p-hydroxyphenylglyoxal, phenylglyoxal, 2,3-butanedione, and 1,2-cyclohexanedione.	Arginine	66-74	ferredoxin reductase	Bos taurus	0-21
21285357-4	2011	In this report, we demonstrate that Ash2L is methylated on arginine residues both in vitro and in cells.	Arginine	59-67	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	36-41
21285357-5	2011	We found that both protein-arginine methyltransferases 1 and 5 methylate Arg-296 within Ash2L.	Arginine	73-76	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	88-93
6127755-0	1982	Effect of somatostatin and two of its analogues on basal and arginine-stimulated insulin and glucagon secretion in the dog.	Arginine	61-69	insulin	Canis lupus familiaris	81-88
21239536-10	2011	These data demonstrate that iNOS expression in pulmonary endothelial cells leads to decreased cellular proliferation, which can be attenuated by preventing cellular L-arg uptake.	Arginine	165-170	nitric oxide synthase 2	Bos taurus	28-32
21308737-13	2011	The CAT-1 isoform plays a role in arginine uptake and, together with PRL/E2-induced NOS, contribute to NO production for the survival of MCF-7 and T47D cells.	Arginine	34-42	solute carrier family 7 member 1	Homo sapiens	4-9
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	nuclear receptor subfamily 0, group B, member 2	Mus musculus	29-32
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Mus musculus	71-74
6127755-5	1982	Arginine stimulation of insulin and glucagon secretion was entirely abolished by SRIF and by the octapeptide during infusion at 0.1 microgram .	Arginine	0-8	insulin	Canis lupus familiaris	24-31
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	transcriptional regulator, SIN3A (yeast)	Mus musculus	76-82
6283633-2	1982	Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products.	Arginine	58-66	proopiomelanocortin	Rattus norvegicus	111-131
7046788-7	1982	kallikrein prefer substrates containing arginine side chains; h. urokinase prefers substrate containing lysine.	Arginine	40-48	kallikrein related peptidase 4	Homo sapiens	0-10
20883807-6	2011	While the clinical therapeutic application of airway biomarkers such as exhaled nitric oxide and beta(2)-adrenoreceptor Arg-16 polymorphism are still in their infancy, they have followed this common pathway of development, and now will require some years of application to demonstrate their true utility as predictive biomarkers of airway status and treatment response.	Arginine	120-123	adrenoceptor beta 2	Homo sapiens	97-119
20641300-6	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) was identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	131-142
6978374-7	1982	The serum carboxypeptidase inhibitor 2-mercaptomethyl-5-guanodinopentanoic acid, which prevents cleavage of the terminal arginine that would produce C3ades Arg-77, allowed us to assay the effects of C3a on in vitro immune response systems where serum is required.	Arginine	121-129	complement C3	Homo sapiens	149-152
21216252-2	2011	Affinity switching of CD44 from a low-affinity state to a high-affinity state is required for normal CD44 physiological function; crystal structures of the CD44 hyaluronan binding domain complexed with HA oligomers point to a conformational rearrangement at a binding site loop, leading to the formation of direct contact between the oligomer and an arginine side chain as a molecular basis for affinity switching.	Arginine	350-358	CD44 molecule (Indian blood group)	Homo sapiens	22-26
6978374-7	1982	The serum carboxypeptidase inhibitor 2-mercaptomethyl-5-guanodinopentanoic acid, which prevents cleavage of the terminal arginine that would produce C3ades Arg-77, allowed us to assay the effects of C3a on in vitro immune response systems where serum is required.	Arginine	156-159	complement C3	Homo sapiens	149-152
21216252-3	2011	Here, all-atom explicit-solvent molecular dynamics simulations were used to characterize the dynamics and thermodynamics of oligomeric hyaluronan (oHA) and its two crystallographic complexes with the CD44 hyaluronan binding domain: the "A-form," which lacks arginine-HA close contact, and the "B-form," which has direct arginine side-chain-HA contact.	Arginine	258-266	CD44 molecule (Indian blood group)	Homo sapiens	200-204
21216252-3	2011	Here, all-atom explicit-solvent molecular dynamics simulations were used to characterize the dynamics and thermodynamics of oligomeric hyaluronan (oHA) and its two crystallographic complexes with the CD44 hyaluronan binding domain: the "A-form," which lacks arginine-HA close contact, and the "B-form," which has direct arginine side-chain-HA contact.	Arginine	320-328	CD44 molecule (Indian blood group)	Homo sapiens	200-204
6978374-8	1982	When  the terminal arginine is removed from C3a, the resulting C3ades Arg-77 molecule is nonsuppressive.	Arginine	19-27	complement C3	Homo sapiens	44-47
6978374-8	1982	When  the terminal arginine is removed from C3a, the resulting C3ades Arg-77 molecule is nonsuppressive.	Arginine	70-73	complement C3	Homo sapiens	44-47
6274867-3	1982	Preincubation of rat neurointermediate lobes for 16 h in the presence of 10 mM canavanine results in the production of pro-opiomelanocortin molecules in which most, if not all, the arginine residues have been replaced by canavanine.	Arginine	181-189	proopiomelanocortin	Rattus norvegicus	119-139
21039601-2	2011	In the nitric oxide (NO) synthesis pathway, nitric oxide synthases (encoded by NOS1, NOS2A, and NOS3) and arginases (encoded by ARG1 and ARG2) compete for L-arginine.	Arginine	155-165	arginase 2	Homo sapiens	137-141
20842464-0	2011	Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia.	Arginine	27-30	TNF receptor superfamily member 1B	Homo sapiens	50-82
20842464-0	2011	Association of the Met-196-Arg variation of human tumor necrosis factor receptor 2 (TNFR2) with paranoid schizophrenia.	Arginine	27-30	TNF receptor superfamily member 1B	Homo sapiens	84-89
7256256-4	1981	The N-terminal amino acids of SCP-1 and SCP-2 are Arginine and Tryptophan respectively.	Arginine	50-58	synaptonemal complex protein 1	Rattus norvegicus	30-35
6112138-1	1981	Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine.	Arginine	122-130	somatostatin	Homo sapiens	0-15
21142177-7	2011	Both Tyr 14 and Arg 241 serve to anchor the dTDP-linked sugar to the protein.	Arginine	16-19	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	44-48
6112138-1	1981	Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine.	Arginine	122-130	somatostatin	Homo sapiens	17-22
6112138-1	1981	Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine.	Arginine	122-130	somatostatin	Homo sapiens	50-65
21385652-10	2011	There was also a linkage disequilibrium found between beta(2)-AR 16 (Arg/Arg) and beta(2)-AR 27 (Gln/Gln).	Arginine	69-72	adrenoceptor beta 2	Homo sapiens	54-64
6112138-1	1981	Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine.	Arginine	122-130	somatostatin	Homo sapiens	67-72
21385652-10	2011	There was also a linkage disequilibrium found between beta(2)-AR 16 (Arg/Arg) and beta(2)-AR 27 (Gln/Gln).	Arginine	69-72	adrenoceptor beta 2	Homo sapiens	82-92
6112138-1	1981	Somatostatin-28 (SS-28) is 380 times as potent as somatostatin-14 (SS-14) to inhibit acutely insulin secretion induced by arginine in vivo; SS-28 is only 3 times as potent as SS-14 to inhibit glucagon secretion induced by arginine.	Arginine	222-230	somatostatin	Homo sapiens	0-15
21385652-10	2011	There was also a linkage disequilibrium found between beta(2)-AR 16 (Arg/Arg) and beta(2)-AR 27 (Gln/Gln).	Arginine	73-76	adrenoceptor beta 2	Homo sapiens	54-64
21385652-10	2011	There was also a linkage disequilibrium found between beta(2)-AR 16 (Arg/Arg) and beta(2)-AR 27 (Gln/Gln).	Arginine	73-76	adrenoceptor beta 2	Homo sapiens	82-92
6112138-2	1981	D-Trp substitution in position 28 of SS-28 increase potency to 2600 times that of SS-14 for inhibition of arginine induced insulin secretion.	Arginine	106-114	somatostatin	Homo sapiens	37-42
6112138-2	1981	D-Trp substitution in position 28 of SS-28 increase potency to 2600 times that of SS-14 for inhibition of arginine induced insulin secretion.	Arginine	106-114	somatostatin	Homo sapiens	82-87
21245169-2	2011	Here we show that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Arg 754 in the KIX region of coactivator p300.	Arginine	89-92	coactivator associated arginine methyltransferase 1	Homo sapiens	18-69
21245169-2	2011	Here we show that coactivator-associated arginine methyltransferase 1 (CARM1) methylates Arg 754 in the KIX region of coactivator p300.	Arginine	89-92	coactivator associated arginine methyltransferase 1	Homo sapiens	71-76
7007799-7	1981	Although glucose-induced IR-GIP responses were not inhibited by the amino acids (1 g/kg) tested, increasing concentrations (up to 1 g/kg) of either alanine or arginine caused progressive inhibition of corn-oil-stimulated IR-GIP responses, in spite of the expected amino-acid-induced rises in insulin concentrations.	Arginine	159-167	insulin	Canis lupus familiaris	292-299
21245169-8	2011	Recruitment of BRCA1 to the p53-binding region of the p21 promoter in response to DNA damage required methylation of Arg 754 of p300 by CARM1.	Arginine	117-120	BRCA1 DNA repair associated	Homo sapiens	15-20
21245169-8	2011	Recruitment of BRCA1 to the p53-binding region of the p21 promoter in response to DNA damage required methylation of Arg 754 of p300 by CARM1.	Arginine	117-120	coactivator associated arginine methyltransferase 1	Homo sapiens	136-141
20940292-8	2011	Mature KLK8 activity was enhanced by calcium and magnesium ions and attenuated by zinc ions and by autocleavage after Arg(164).	Arginine	118-121	kallikrein related peptidase 8	Homo sapiens	7-11
6933565-4	1980	Peptide mapping analysis revealed that the structural abnormality of PGK-Uppsala is a single amino acid substitution from arginine to proline at the 206th position.	Arginine	122-130	phosphoglycerate kinase 1	Equus caballus	69-72
21249762-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
7190836-3	1980	The rates of hydrolysis of the Arg-Gly bond in these peptides by thrombin were measured, and the values of the specificity constant, kcat/KM, were all found to be approximately 2 X 10(-7) [(NIH unit/L)s]-1, similar to that for a peptide (F-3) having an additional Arg residue between Glu- and -NHCH3 of F-4.	Arginine	31-34	coagulation factor II, thrombin	Bos taurus	65-73
7190836-3	1980	The rates of hydrolysis of the Arg-Gly bond in these peptides by thrombin were measured, and the values of the specificity constant, kcat/KM, were all found to be approximately 2 X 10(-7) [(NIH unit/L)s]-1, similar to that for a peptide (F-3) having an additional Arg residue between Glu- and -NHCH3 of F-4.	Arginine	264-267	coagulation factor II, thrombin	Bos taurus	65-73
7190836-6	1980	The active site of thrombin thus appears to interact with a peptide of the size of F-6, with the Phe residue possibly being in close spatial proximity to the Val-Arg-Gly moiety.	Arginine	162-165	coagulation factor II, thrombin	Bos taurus	19-27
20937786-3	2011	The peptide T140, which contains five arginine residues, is the most potent antagonist of CXCR4 developed to date.	Arginine	38-46	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
6108171-7	1980	Arginine-stimulated insulin and growth hormone (hGH) concentrations were considerably lowered by the somatostatin infusion.	Arginine	0-8	somatostatin	Homo sapiens	101-113
22094842-5	2011	CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors.	Arginine	70-73	adrenoceptor beta 2	Homo sapiens	82-87
7440061-3	1980	The octacosapeptide amide corresponding to the entire amino acid sequence of chicken VIP was synthesized in a conventional manner, using a new arginine derivative, NG-mesitylene-2-sulfonylarginine, Arg(Mts).	Arginine	143-151	vasoactive intestinal peptide	Gallus gallus	85-88
21881228-5	2011	Malformin A1 action was abolished by Arg-Gly-Asp peptide (a competitor of vitronectin-integrin binding), wortmannin (an inhibitor of signaling kinases), and cytochalasin B (an inhibitor of actin polymerization).	Arginine	37-40	vitronectin	Homo sapiens	74-85
7440061-3	1980	The octacosapeptide amide corresponding to the entire amino acid sequence of chicken VIP was synthesized in a conventional manner, using a new arginine derivative, NG-mesitylene-2-sulfonylarginine, Arg(Mts).	Arginine	198-201	vasoactive intestinal peptide	Gallus gallus	85-88
6993600-0	1980	Effects of arginine and glucose on the release of insulin in the sheep fetus.	Arginine	11-19	LOC105613195	Ovis aries	50-57
20882560-12	2011	The effects of platelet depletion on necrosis, neutrophils and MPO levels were confirmed in L-arginine-induced pancreatitis.	Arginine	92-102	myeloperoxidase	Mus musculus	63-66
20674388-3	2011	The denatured recombinant human IL-17A variant was refolded in 20 mM Tris-HCl, pH 9.0, 500 mM arginine, 500 mM guanidine HCl, 15% glycerol, 1 mM cystamine, and 5 mM cysteine at 2-8 C for 40 h. The refolded IL-17A variant was subsequently purified using a combination of cation-exchange, reversed-phase and fluoroapatite chromatography.	Arginine	94-102	interleukin 17A	Homo sapiens	32-38
6993600-1	1980	The effect of L-arginine on fetal insulin release has been investigated in the chronically catheterized sheep fetus and the findings have been compared with the beta cell response to glucose.	Arginine	14-24	LOC105613195	Ovis aries	34-41
6993600-2	1980	An infusion of arginine for 5 min (200 mg as a solution of 11.5 mmol/l) stimulated a rapid release of insulin in all the fetuses from 119 to 142 days of gestational age.	Arginine	15-23	LOC105613195	Ovis aries	102-109
6993600-4	1980	The response to infusion of glucose for 5 min (1 g as a solution of 2.8 mol/l) was more variable and slower than that to arginine with the peak concentration of insulin occurring 10 min after the end of infusion.	Arginine	121-129	LOC105613195	Ovis aries	161-168
6249588-2	1980	Covalent spin labelling of lysine and arginine residues in histone H1 under specified conditions allows the study of histone-DNA interaction.	Arginine	38-46	spindlin 1	Homo sapiens	9-13
21127848-1	2011	Several laboratories have carried out molecular dynamics (MD) simulations of arginine interactions with lipid bilayers and found that the energetic cost of placing arginine in lipid bilayers is an order of magnitude greater than observed in molecular biology experiments in which Arg-containing transmembrane helices are inserted across the endoplasmic reticulum membrane by the Sec61 translocon.	Arginine	164-172	SEC61 translocon subunit alpha 1	Homo sapiens	379-384
518871-7	1979	However, in this case the latent thrombin activity is progressively diminished during the heating process in terms of both clotting activity and hydrolysis of the amide substrate H-D-Phe-Pip-Arg-pNA.	Arginine	191-194	coagulation factor II, thrombin	Bos taurus	33-41
21175895-2	2011	In this work, we successfully identified and characterized arginine methylation as a crucial type of post-translational modification in the activity regulation of the cytosolic translation repressor protein NAB1 in the plant model organism Chlamydomonas reinhardtii.	Arginine	59-67	uncharacterized protein	Chlamydomonas reinhardtii	207-211
21175895-4	2011	Protein arginine methylation of NAB1 could be demonstrated by PRMT1 catalyzed methylation of recombinant NAB1 in vitro, and by immunodetection of methylated NAB1 arginines in vivo.	Arginine	8-16	uncharacterized protein	Chlamydomonas reinhardtii	32-36
21175895-4	2011	Protein arginine methylation of NAB1 could be demonstrated by PRMT1 catalyzed methylation of recombinant NAB1 in vitro, and by immunodetection of methylated NAB1 arginines in vivo.	Arginine	8-16	uncharacterized protein	Chlamydomonas reinhardtii	62-67
21175895-4	2011	Protein arginine methylation of NAB1 could be demonstrated by PRMT1 catalyzed methylation of recombinant NAB1 in vitro, and by immunodetection of methylated NAB1 arginines in vivo.	Arginine	8-16	uncharacterized protein	Chlamydomonas reinhardtii	105-109
376297-6	1979	Neurotensin also significantly inhibited the elevations in glucagon, insulin, and somatostatin release induced by 20 mM arginine.	Arginine	120-128	neurotensin	Rattus norvegicus	0-11
21175895-4	2011	Protein arginine methylation of NAB1 could be demonstrated by PRMT1 catalyzed methylation of recombinant NAB1 in vitro, and by immunodetection of methylated NAB1 arginines in vivo.	Arginine	8-16	uncharacterized protein	Chlamydomonas reinhardtii	105-109
21175895-4	2011	Protein arginine methylation of NAB1 could be demonstrated by PRMT1 catalyzed methylation of recombinant NAB1 in vitro, and by immunodetection of methylated NAB1 arginines in vivo.	Arginine	162-171	uncharacterized protein	Chlamydomonas reinhardtii	32-36
21175895-6	2011	The extent of NAB1 arginine methylation depends on the growth conditions, with phototrophic growth causing a high methylation state and heterotrophic growth resulting in lowered methylation of the protein.	Arginine	19-27	uncharacterized protein	Chlamydomonas reinhardtii	14-18
21175895-7	2011	In addition, we could show that NAB1 activity regulation by arginine methylation operates independently from cysteine-based redox control, which has previously been shown to control the activity of NAB1.	Arginine	60-68	uncharacterized protein	Chlamydomonas reinhardtii	32-36
21175895-7	2011	In addition, we could show that NAB1 activity regulation by arginine methylation operates independently from cysteine-based redox control, which has previously been shown to control the activity of NAB1.	Arginine	60-68	uncharacterized protein	Chlamydomonas reinhardtii	198-202
376297-7	1979	It is concluded that neurotensin exerts a dual effect on the endocrine pancreas in vitro: 1) at low glucose concentration and over short term (20 min) incubations, the peptide stimulates insulin, glucagon, and somatostatin release; and 2) under stimulated conditions (high glucose or arginine), neurotensin inhibits insulin, glucagon, and somatostatin release.	Arginine	284-292	neurotensin	Rattus norvegicus	21-32
34422-7	1979	Titration of the acid fluorescence transition in bovine neurophysins-I and -II, and in bovine neurophysin-II treated with carboxypeptidase B to remove the Arg-Arg-Val sequence at the carboxyl terminus, indicates that this transition is due to titration of a side-chain carboxyl with an intrinsic pK of 4.6.	Arginine	155-158	arginine vasopressin	Bos taurus	94-108
22174908-1	2011	Novel bifunctional N-acetylglutamate synthase/kinases (NAGS/K) that catalyze the first two steps of arginine biosynthesis and are homologous to vertebrate N-acetylglutamate synthase (NAGS), an essential cofactor-producing enzyme in the urea cycle, were identified in Maricaulis maris and several other bacteria.	Arginine	100-108	N-acetylglutamate synthase	Homo sapiens	55-59
22174908-1	2011	Novel bifunctional N-acetylglutamate synthase/kinases (NAGS/K) that catalyze the first two steps of arginine biosynthesis and are homologous to vertebrate N-acetylglutamate synthase (NAGS), an essential cofactor-producing enzyme in the urea cycle, were identified in Maricaulis maris and several other bacteria.	Arginine	100-108	N-acetylglutamate synthase	Homo sapiens	183-187
22174908-2	2011	Arginine is an allosteric inhibitor of NAGS but not NAGK activity.	Arginine	0-8	N-acetylglutamate synthase	Homo sapiens	39-43
22194966-2	2011	This posttranslational modification of arginine was recently discovered on inflammatory chemokines including CXCL8 and CXCL10, and significantly reduced their biological activity.	Arginine	39-47	C-X-C motif chemokine ligand 10	Homo sapiens	119-125
34422-7	1979	Titration of the acid fluorescence transition in bovine neurophysins-I and -II, and in bovine neurophysin-II treated with carboxypeptidase B to remove the Arg-Arg-Val sequence at the carboxyl terminus, indicates that this transition is due to titration of a side-chain carboxyl with an intrinsic pK of 4.6.	Arginine	155-158	carboxypeptidase B1	Bos taurus	122-140
34422-7	1979	Titration of the acid fluorescence transition in bovine neurophysins-I and -II, and in bovine neurophysin-II treated with carboxypeptidase B to remove the Arg-Arg-Val sequence at the carboxyl terminus, indicates that this transition is due to titration of a side-chain carboxyl with an intrinsic pK of 4.6.	Arginine	159-162	carboxypeptidase B1	Bos taurus	122-140
103576-2	1978	The inhibitor has a molecular weight near 68,000 and contains approximately 26% carbohydrate alpha-1-Antichymotrypsin has an amino-terminal arginine and a carboxy-terminal glycine.	Arginine	140-148	serpin family A member 3	Homo sapiens	93-117
22046437-4	2011	We found that CARM1 facilitates Sox2-mediated transactivation and directly methylates Sox2 at arginine 113.	Arginine	94-102	coactivator associated arginine methyltransferase 1	Homo sapiens	14-19
22046437-4	2011	We found that CARM1 facilitates Sox2-mediated transactivation and directly methylates Sox2 at arginine 113.	Arginine	94-102	SRY-box transcription factor 2	Homo sapiens	86-90
22046437-7	2011	Our study reveals the direct regulation of Sox2 by CARM1 that sheds lights on how arginine methylation signals are integrated into the pluripotent transcription factor network.	Arginine	82-90	SRY-box transcription factor 2	Homo sapiens	43-47
22046437-7	2011	Our study reveals the direct regulation of Sox2 by CARM1 that sheds lights on how arginine methylation signals are integrated into the pluripotent transcription factor network.	Arginine	82-90	coactivator associated arginine methyltransferase 1	Homo sapiens	51-56
215210-0	1978	The role of arginine residues in the function of D-glyceraldehyde-3-phosphate dehydrogenase.	Arginine	12-20	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	51-91
30754-6	1978	Measurement of amino acid uptake show that the mutants with high glutamine synthetase levels have increased rates for glutamine, arginine, aspartate, and lysine, but a decreased rate for proline.	Arginine	129-137	type I glutamate--ammonia ligase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	65-85
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Arginine	7-12	proliferating cell nuclear antigen	Rattus norvegicus	221-255
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Arginine	7-12	proliferating cell nuclear antigen	Rattus norvegicus	257-261
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Arginine	168-173	proliferating cell nuclear antigen	Rattus norvegicus	221-255
21187161-5	2011	TG and L-arg administrations significantly ameliorated the histopathology of injured carotid artery, which was abolished or blunted by L-NAME, an NOS inhibitor; TG and L-arg could also remarkably reduce the expression of proliferating cell nuclear antigen (PCNA), a proliferation marker of vascular smooth muscle cells(VSMCs), in neointima of the injured artery wall.	Arginine	168-173	proliferating cell nuclear antigen	Rattus norvegicus	257-261
122721-8	1978	From these results, the arginine or arginine-arginine residue down to the C-terminal leucine appears to be essential for the smooth muscle contracting activity of neurotensin.	Arginine	24-32	neurotensin/neuromedin N	Oryctolagus cuniculus	163-174
20966082-7	2010	Comparing the electrostatic surface potentials of the ECDs suggests a charge compatibility mechanism for ligand discrimination involving a single amino acid difference in the receptors (CRFR1 Glu104/CRFR2alpha Pro-100) at a site proximate to peptide residue 35 (Arg in CRF/Ucn1, Ala in Ucn2/3).	Arginine	262-265	corticotropin releasing hormone receptor 2	Mus musculus	199-209
122721-8	1978	From these results, the arginine or arginine-arginine residue down to the C-terminal leucine appears to be essential for the smooth muscle contracting activity of neurotensin.	Arginine	36-44	neurotensin/neuromedin N	Oryctolagus cuniculus	163-174
21109197-6	2010	Deacetylation of HMGCS2 lysines 310, 447, and 473 by incubation with wild-type SIRT3 or by mutation to arginine enhances its enzymatic activity.	Arginine	103-111	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	17-23
122721-8	1978	From these results, the arginine or arginine-arginine residue down to the C-terminal leucine appears to be essential for the smooth muscle contracting activity of neurotensin.	Arginine	36-44	neurotensin/neuromedin N	Oryctolagus cuniculus	163-174
666896-7	1978	One mole of arginine or phenylalanine was released per mole of ligandin after digestion with carboxypeptidase B or A, respectively.	Arginine	12-20	carboxypeptidase B1	Homo sapiens	93-111
20663564-11	2010	After permutation, there was a significant association in the non-synonymous polymorphism rs2229094(T C) in the LTA gene (P = 0.0283), which encodes a cysteine to arginine change in the signal peptide.	Arginine	163-171	lymphotoxin alpha	Homo sapiens	112-115
667683-8	1978	On the other hand, CPB is similar to trypsin (ibid) in that the best substrate would have a side chain length between those of lysine and arginine.	Arginine	138-146	carboxypeptidase B1	Homo sapiens	19-22
628880-1	1978	Human lymphoblasts in long-term culture have the enzyme activities necessary to convert citrulline to arginine: argininosuccinate synthetase and argininosuccinate lyase.	Arginine	102-110	argininosuccinate lyase	Homo sapiens	145-168
20855893-5	2010	GCK inactivation and down-regulation were predominantly mediated by ethanol metabolism-generated peroxynitrite, which were suppressed by the peroxynitrite scavengers N(gamma)-monomethyl-L-arginine, uric acid, and deferoxamine but not by the S-nitrosylation inhibitor DTT, indicating that tyrosine nitration is the predominant modification associated with GCK down-regulation and inactivation rather than S-nitrosylation of cysteine.	Arginine	185-196	glucokinase	Homo sapiens	0-3
20736165-14	2010	Two functionally distinct phosphoinositide binding regions (Tyr(501)-Arg(512) and Arg(520)-Arg(552)) are present in the NHE3 F1 domain; both regions are important for serum stimulation, but they display differences in phosphoinositide binding, and the latter but not the former alters NHE3 surface expression.	Arginine	82-85	solute carrier family 9 member A3	Homo sapiens	120-124
897837-3	1977	Arginine, presumably via insulin release, caused a fall in free fatty acids (FFA) in controls, which was inhibited by somatostatin.	Arginine	0-8	somatostatin	Homo sapiens	118-130
20810653-0	2010	srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.	Arginine	7-15	SLIT-ROBO Rho GTPase activating protein 2	Homo sapiens	0-6
20810653-5	2010	PRMT5 binds to the N terminus of srGAP2 (225-538 aa) and methylates its C-terminal arginine residue Arg-927.	Arginine	83-91	SLIT-ROBO Rho GTPase activating protein 2	Homo sapiens	33-39
861310-4	1977	Generation of esterase activity requires the presence of an enzyme--factor Xa, which splits the 323-324 peptide bond (Arg-Ile) in the molecules of prothrombin and intermediate products of its activation.	Arginine	118-121	coagulation factor II, thrombin	Bos taurus	147-158
20810653-5	2010	PRMT5 binds to the N terminus of srGAP2 (225-538 aa) and methylates its C-terminal arginine residue Arg-927.	Arginine	100-103	SLIT-ROBO Rho GTPase activating protein 2	Homo sapiens	33-39
20810653-7	2010	These results suggest that srGAP2 arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.	Arginine	34-42	SLIT-ROBO Rho GTPase activating protein 2	Homo sapiens	27-33
20484304-3	2010	L-Arg is synthesized by renal argininosuccinate synthase/argininosuccinate lyase (ASS/ASL) and then either consumed within the kidney by arginase II or NOS or released into the circulation.	Arginine	0-5	argininosuccinate synthase 1	Rattus norvegicus	30-56
20484304-3	2010	L-Arg is synthesized by renal argininosuccinate synthase/argininosuccinate lyase (ASS/ASL) and then either consumed within the kidney by arginase II or NOS or released into the circulation.	Arginine	0-5	arginase 2	Rattus norvegicus	137-148
20923641-6	2010	We further characterized a mutation, Cx50N9R, where the Asn (N) at the ninth position of Cx50 was replaced by the corresponding Arg (R) at Cx36.	Arginine	128-131	gap junction protein, delta 2	Mus musculus	139-143
1017794-4	1976	The fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z)(I) and Boc-Pro-His(Trt)-Ile-Cys(Trt)-Arg(Tos) (II) were synthesized conventionally.	Arginine	87-90	BOC cell adhesion associated, oncogene regulated	Homo sapiens	14-17
20804732-0	2010	Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property.	Arginine	0-8	heat shock protein family A (Hsp70) member 8	Homo sapiens	42-47
1017794-4	1976	The fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z)(I) and Boc-Pro-His(Trt)-Ile-Cys(Trt)-Arg(Tos) (II) were synthesized conventionally.	Arginine	87-90	BOC cell adhesion associated, oncogene regulated	Homo sapiens	57-60
803505-16	1975	The sequence adjacent to the COOH-terminal arginine was Leu-Ala-Arg-COOH for both humans and porcine C3a.	Arginine	43-51	complement C3	Homo sapiens	101-104
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Arginine	54-63	zinc finger and BTB domain containing 7B	Homo sapiens	75-80
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Arginine	54-63	CD8a molecule	Homo sapiens	136-139
20810990-6	2010	In contrast, mutation of lysines 210, 216, and 339 to arginines stabilizes ThPOK and enhances its ability to suppress the expression of CD8 molecule and cytotoxic effectors in CD8 T cells.	Arginine	54-63	CD8a molecule	Homo sapiens	176-179
1109389-1	1975	In contrast to the earlier reports on the age-dependent reduction of the ratio of F3 plus F2al plus F2a2 / Fl plus F2b in rat liver histones and the reduction of arginine-rich histone (F3 or III) in beef thymus, the result obtained by high-resolution polyacrylamide gel electrophoresis of histones shows no apparent age-related change in the proportion of any histone fraction of mouse and rat liver chromatin.	Arginine	162-170	coagulation factor III, tissue factor	Rattus norvegicus	185-194
20558222-11	2010	In conclusion, GlyT1 and CAT1 most likely mediate glycine and L-arginine uptake, respectively, by Muller cells and are expected to play an important role in supplying precursors for creatine biosynthesis in Muller cells.	Arginine	62-72	solute carrier family 6 member 9	Rattus norvegicus	15-20
236567-1	1975	Exposure of purified Hageman factor (HF, Factor XII) to phenylglyoxal hydrate (PHG), an agent reacting with arginine residues in protein, inhibited its coagulant properties upon subsequent exposure of negatively charged agents.	Arginine	108-116	coagulation factor XII	Homo sapiens	21-35
20931522-4	2010	RESULTS: In exon 12 of the TGFBI gene, 1664G to A change was detected in all the patients, which leads to an amino acid replacement of arginine with glutamine (p.Arg555Gln).	Arginine	135-143	transforming growth factor beta induced	Homo sapiens	27-32
236567-1	1975	Exposure of purified Hageman factor (HF, Factor XII) to phenylglyoxal hydrate (PHG), an agent reacting with arginine residues in protein, inhibited its coagulant properties upon subsequent exposure of negatively charged agents.	Arginine	108-116	coagulation factor XII	Homo sapiens	37-39
5065066-0	1972	Chemical evidence for a functional arginine residue in carboxypeptidase B.	Arginine	35-43	carboxypeptidase B1	Homo sapiens	55-73
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	C-X-C motif chemokine ligand 5	Homo sapiens	5-10
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	C-X-C motif chemokine ligand 5	Homo sapiens	82-87
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	C-X-C motif chemokine ligand 5	Homo sapiens	82-87
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	C-X-C motif chemokine ligand 5	Homo sapiens	82-87
20630876-3	2010	Slow CXCL5(1-78) processing by the myeloid cell marker aminopeptidase N/CD13 into CXCL5(2-78) hardly affected its in vitro activity, but slowed down the activation of CXCL5 by the neutrophil protease cathepsin G. PAD, an enzyme with a potentially important function in autoimmune diseases, site-specifically deiminated Arg(9) in CXCL5 to citrulline, generating [Cit(9)]CXCL5(1-78).	Arginine	319-322	C-X-C motif chemokine ligand 5	Homo sapiens	82-87
5097573-9	1971	In elastin from plaque intima, the following polar amino acids were increased significantly: aspartic acid, threonine, serine, glutamic acid, lysine, histidine, and arginine; whereas, cross-linking amino acids: desmosine, isodesmosine, and lysinonorleucine were decreased significantly.	Arginine	165-173	elastin	Homo sapiens	3-10
20632993-9	2010	A single amino acid difference in the ALK substrate peptide binding P-1 site (where the P-site is the phosphoacceptor site) was identified that, in conjunction with A-loop sequence variation including the RAS (Arg-Ala-Ser)-motif, rationalizes the difference in the A-loop tyrosine autophosphorylation preference between ALK and IGF1RK/IRK.	Arginine	210-213	ALK receptor tyrosine kinase	Homo sapiens	38-41
20632993-9	2010	A single amino acid difference in the ALK substrate peptide binding P-1 site (where the P-site is the phosphoacceptor site) was identified that, in conjunction with A-loop sequence variation including the RAS (Arg-Ala-Ser)-motif, rationalizes the difference in the A-loop tyrosine autophosphorylation preference between ALK and IGF1RK/IRK.	Arginine	210-213	ALK receptor tyrosine kinase	Homo sapiens	320-323
5486495-0	1970	Regulation of arginine biosynthesis in Chlamydomonas reinhardii: studies in vivo and of ornithine transcarbamoylase and argininosuccinate lyase activities.	Arginine	14-22	argininosuccinate lyase	Homo sapiens	120-143
20497508-1	2010	BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) catalyzes the majority of arginine methylation in cells and plays important roles in the differentiation and development of neurons.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	50-55
5457056-0	1970	Role of kidney arginase in variations of the arginine requirement of chicks.	Arginine	45-53	arginase 2	Homo sapiens	8-23
20617841-15	2010	In Arp K3(1) an Arg residue fills site 72, replacing the key aromatic residue found in other kringles, thus interfering with a requisite kringle-ligand hydrophobic interaction.	Arginine	16-19	arginine-glutamic acid dipeptide repeats	Homo sapiens	3-6
20551327-4	2010	Immunopurification and N-terminal sequencing of this cell-retained fragment and detailed mutagenesis, show that proteolytic processing of CDCP1 occurs at two sites, Arg-368 and Lys-369.	Arginine	165-168	CUB domain containing protein 1	Homo sapiens	138-143
5435518-0	1970	Growth hormone and insulin secretory responses to arginine in the sheep, pig, and cow.	Arginine	50-58	LOC105613195	Ovis aries	19-26
5957133-0	1966	Purification of a mammalian peptidase selective for N-terminal arginine and lysine residues: aminopeptidase B.	Arginine	63-71	arginyl aminopeptidase	Homo sapiens	93-109
20551327-5	2010	We show that the serine protease matriptase is an efficient, but not essential, cellular processor of CDCP1 at Arg-368.	Arginine	111-114	CUB domain containing protein 1	Homo sapiens	102-107
20684782-7	2010	RESULTS: While the wild-type strain had no observable phenotype upon depletion for any amino acid, the gcn2 Delta strain showed slow growth in media devoid of only Trp or Arg.	Arginine	171-174	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	103-107
20684782-8	2010	Consistent with the growth phenotypes, profiles of genome-wide tRNA charging revealed significant decrease in cognate tRNA charging only in the gcn2 Delta strain upon depletion for Trp or Arg.	Arginine	188-191	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	144-148
20684782-15	2010	This study highlights the importance of the GCN2 eIF2 kinase pathway for maintaining metabolic homeostasis, contributing to appropriate tRNA charging and growth adaptation in response to culture conditions deficient for the central amino acids, tryptophan and arginine.	Arginine	260-268	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	44-48
33989303-5	2021	The inhibition of PRMT5 led to growth suppression and induction of apoptosis, while selectively decreasing global marks of symmetric dimethylarginine (SDMA) and histone H4 arginine 3 symmetric dimethylation.	Arginine	141-149	protein arginine methyltransferase 5	Canis lupus familiaris	18-23
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Arginine	13-16	N-acetyltransferase 2	Homo sapiens	51-55
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Arginine	13-16	N-acetyltransferase 2	Homo sapiens	61-65
20871037-8	2010	Ile(114) and Arg(197), which are mutation sites of NAT2*4 to NAT2*5 and NAT2*6, were located in the peripheral part of the positive field.	Arginine	13-16	N-acetyltransferase 2	Homo sapiens	61-65
33853662-2	2021	PRMT1 which triggers asymmetric dimethylation of histone H4 on arginine 3 (H4R3me2a) is upregulated in human colorectal cancer (CRC) and is essential for cell proliferation.	Arginine	63-71	protein arginine methyltransferase 1	Homo sapiens	0-5
20116391-3	2010	We have recently shown that ERalpha is methylated specifically by the arginine methyltransferase PRMT1 at arginine 260 in the DNA-binding domain of the receptor.	Arginine	70-78	protein arginine methyltransferase 1	Homo sapiens	97-102
33683322-7	2021	Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing angiotensin 1-7 and activating the MasR while blocking angiotensin III formation, contributes to the antihypertensive effect and the decrease in arginine-vasopressin release induced by RB150/firibastat.	Arginine	300-308	angiotensin I converting enzyme 2	Rattus norvegicus	56-60
20662138-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
33741961-3	2021	Here we show that CHD4 regulates expression of PADI1 (Protein Arginine Deiminase 1) and PADI3 in multiple cancer cell types modulating citrullination of arginine residues of the allosterically-regulated glycolytic enzyme pyruvate kinase M2 (PKM2).	Arginine	153-161	peptidyl arginine deiminase 3	Homo sapiens	88-93
33398168-3	2021	Specifically, CRL2 using the related substrate adapters FEM1A/B/C was found to recognize C degrons ending with arginine (Arg/C-degron).	Arginine	111-119	DAN domain BMP antagonist family member 5	Homo sapiens	14-18
20421418-6	2010	In this current study, we identified the direct interaction between p62 and Keap1 and the residues required for the interaction have been mapped to 349-DPSTGE-354 in p62 and three arginines in the Kelch domain of Keap1.	Arginine	180-189	nucleoporin 62	Homo sapiens	68-71
33398168-3	2021	Specifically, CRL2 using the related substrate adapters FEM1A/B/C was found to recognize C degrons ending with arginine (Arg/C-degron).	Arginine	121-124	DAN domain BMP antagonist family member 5	Homo sapiens	14-18
19447018-9	2010	Results showed that the MMP-2, MMP-9 and VEGF receptor levels in tumors were significantly lower, whereas tumor NO levels and spleen natural killer (NK) cell activities were higher in the Arg group than in the control group.	Arginine	188-191	matrix metallopeptidase 9	Homo sapiens	31-36
33398168-5	2021	Our structural research, complemented by binding assays and global protein stability (GPS) analyses, demonstrates that FEM1A/C and FEM1B selectively target distinct classes of Arg/C-degrons.	Arginine	176-179	fem-1 homolog B	Homo sapiens	131-136
33398170-3	2021	FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive.	Arginine	63-71	cytokine receptor like factor 2	Homo sapiens	11-15
33398170-3	2021	FEM1C is a CRL2 substrate receptor that targets the C-terminal arginine degron (Arg/C-degron), but the molecular mechanism of substrate recognition remains largely elusive.	Arginine	80-83	cytokine receptor like factor 2	Homo sapiens	11-15
33630211-0	2021	Arginine Regulates NLRP3 Inflammasome Activation Through SIRT1 in Vascular Endothelial Cells.	Arginine	0-8	sirtuin 1	Homo sapiens	57-62
20308322-0	2010	Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.	Arginine	0-8	serine and arginine rich splicing factor 1	Homo sapiens	108-111
20308322-0	2010	Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF.	Arginine	0-8	serine and arginine rich splicing factor 1	Homo sapiens	112-115
20308322-4	2010	We confirmed that human SF2/ASF is methylated at residues R93, R97, and R109, which were identified in a global proteomic analysis of Arg methylation, and further investigated whether these methylated residues regulate the properties of SF2/ASF.	Arginine	134-137	serine and arginine rich splicing factor 1	Homo sapiens	24-27
20308322-4	2010	We confirmed that human SF2/ASF is methylated at residues R93, R97, and R109, which were identified in a global proteomic analysis of Arg methylation, and further investigated whether these methylated residues regulate the properties of SF2/ASF.	Arginine	134-137	serine and arginine rich splicing factor 1	Homo sapiens	28-31
20308322-5	2010	We show that the three arginines additively control the subcellular localization of SF2/ASF and that both the positive charge and the methylation state are important.	Arginine	23-32	serine and arginine rich splicing factor 1	Homo sapiens	84-87
20308322-5	2010	We show that the three arginines additively control the subcellular localization of SF2/ASF and that both the positive charge and the methylation state are important.	Arginine	23-32	serine and arginine rich splicing factor 1	Homo sapiens	88-91
20308322-8	2010	This study addresses the mechanisms by which Arg methylation and the associated positive charge regulate the activities of SF2/ASF and emphasizes the significance of localization control for an oncoprotein with multiple functions in different cellular compartments.	Arginine	45-48	serine and arginine rich splicing factor 1	Homo sapiens	123-126
33630211-5	2021	Moreover, treatment with Arg increased the expression of the deacetylase sirtuin 1 (SIRT1) in ECs.	Arginine	25-28	sirtuin 1	Homo sapiens	73-82
33630211-5	2021	Moreover, treatment with Arg increased the expression of the deacetylase sirtuin 1 (SIRT1) in ECs.	Arginine	25-28	sirtuin 1	Homo sapiens	84-89
33630211-6	2021	Importantly, knockdown of SIRT1 abolished the inhibitory potential of Arg on the activation of NLRP3 inflammasome.	Arginine	70-73	sirtuin 1	Homo sapiens	26-31
33630211-9	2021	In combination, we speculate that Arg exerts an inhibitory effect on the activation of NLRP3 inflammasome in ECs, which may be partly mediated by SIRT1 and ROS.	Arginine	34-37	sirtuin 1	Homo sapiens	146-151
33141452-2	2021	Herein, we synthesized actiniae-like carbon nitride (ACN) bundles based on the pyrolysis of an asymmetric supramolecular precursor prepared from L-arginine (L-Arg) and melamine.	Arginine	145-155	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	53-56
20308322-8	2010	This study addresses the mechanisms by which Arg methylation and the associated positive charge regulate the activities of SF2/ASF and emphasizes the significance of localization control for an oncoprotein with multiple functions in different cellular compartments.	Arginine	45-48	serine and arginine rich splicing factor 1	Homo sapiens	127-130
33141452-2	2021	Herein, we synthesized actiniae-like carbon nitride (ACN) bundles based on the pyrolysis of an asymmetric supramolecular precursor prepared from L-arginine (L-Arg) and melamine.	Arginine	157-162	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	53-56
20123736-4	2010	TRAP150 contains an arginine/serine-rich domain and has sequence similarity with the cell death-promoting transcriptional repressor BCLAF1.	Arginine	20-28	BCL2 associated transcription factor 1	Homo sapiens	132-138
33579648-10	2021	However, supplementing the diet of male or female broilers from 29 to 42 days of age with L-arginine at a concentration of 6.87 g/kg represents a nutritional strategy to improve feed conversion and reduce circulating triacylglycerol and cholesterol levels, NADPH synthesis by liver malic enzyme and abdominal fat deposition, without negatively affecting the carcass and noble cuts yield, the amount of nitrogen excreted by the broilers and the energy value of the feed.	Arginine	90-100	2,4-dienoyl-CoA reductase 1	Homo sapiens	257-262
20129943-0	2010	Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.	Arginine	0-8	Aly/REF export factor	Homo sapiens	28-31
33334587-0	2021	Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteres.	Arginine	82-85	hepsin	Homo sapiens	59-65
20061288-12	2010	Genetic testing revealed a C to T transition at nucleotide 268 in exon 3 of the SDHB gene, resulting in a change from an arginine to a stop codon (Arg90X) and leading to a truncated SDHB protein.	Arginine	121-129	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	80-84
20231378-0	2010	Arginine methylation of the B cell antigen receptor promotes differentiation.	Arginine	0-8	BCR activator of RhoGEF and GTPase	Homo sapiens	28-51
20231378-3	2010	We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1.	Arginine	25-33	BCR activator of RhoGEF and GTPase	Homo sapiens	85-88
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Arginine	81-89	solute carrier family 7 member 1	Homo sapiens	0-6
20231378-5	2010	Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.	Arginine	14-22	BCR activator of RhoGEF and GTPase	Homo sapiens	91-94
20146487-3	2010	We used affinity purification to identify N-WASp as a novel binding partner of Arg.	Arginine	79-82	WASP like actin nucleation promoting factor	Homo sapiens	42-48
20146487-5	2010	We find that the Arg SH3 domain binds directly to N-WASp.	Arginine	17-20	WASP like actin nucleation promoting factor	Homo sapiens	50-56
33211385-3	2021	SLC7A1/CAT1 is a transporter responsible for the uptake of cationic amino acids (arginine, lysine, and ornithine) essential for cellular growth.	Arginine	81-89	solute carrier family 7 member 1	Homo sapiens	7-11
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	0-3	WASP like actin nucleation promoting factor	Homo sapiens	19-25
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	0-3	WASP like actin nucleation promoting factor	Homo sapiens	79-85
33332208-7	2021	These modules, sharing three lncRNAs (GS1-358P8.4, OIP5-AS1, and RP11-690D19.3), were significantly enriched in biological pathways such as regulation of actin cytoskeleton, tryptophan metabolism, lysosome, and arginine and proline metabolism.	Arginine	211-219	pre-mRNA processing factor 31	Homo sapiens	65-69
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	71-74	WASP like actin nucleation promoting factor	Homo sapiens	19-25
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	71-74	WASP like actin nucleation promoting factor	Homo sapiens	79-85
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	71-74	WASP like actin nucleation promoting factor	Homo sapiens	19-25
20146487-6	2010	Arg phosphorylates N-WASp on Y256, modestly increasing the affinity of Arg for N-WASp, an interaction that does not require the Arg SH2 domain.	Arginine	71-74	WASP like actin nucleation promoting factor	Homo sapiens	79-85
20146487-7	2010	The Arg SH3 domain stimulates N-WASp-dependent actin polymerization in vitro, and Arg phosphorylation of N-WASp weakly stimulates this effect.	Arginine	4-7	WASP like actin nucleation promoting factor	Homo sapiens	30-36
20146487-10	2010	These results suggest that Arg promotes actin-based protrusions in response to extracellular stimuli through phosphorylation of and physical interactions with N-WASp.	Arginine	27-30	WASP like actin nucleation promoting factor	Homo sapiens	159-165
33747724-1	2021	Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally charged citrulline, and this activity has been associated with the onset and progression of multiple cancers.	Arginine	8-16	peptidyl arginine deiminase 2	Homo sapiens	31-36
33747724-4	2021	Mechanistically, PADI2 interacting and catalyzing MEK1 citrullination at arginine 113/189 facilitates MEK1 on extracellular signal-regulated protein kinases 1/2 (ERK1/2) phosphorylation, which activates insulin-like growth factor-II binding protein 1 (IGF2BP1) expression.	Arginine	73-81	peptidyl arginine deiminase 2	Homo sapiens	17-22
33747724-4	2021	Mechanistically, PADI2 interacting and catalyzing MEK1 citrullination at arginine 113/189 facilitates MEK1 on extracellular signal-regulated protein kinases 1/2 (ERK1/2) phosphorylation, which activates insulin-like growth factor-II binding protein 1 (IGF2BP1) expression.	Arginine	73-81	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	252-259
19935701-8	2010	In addition, lysine 96 residue is essential for ING3 ubiquitination as its mutation to arginine dramatically abrogated ING3 degradation.	Arginine	87-95	inhibitor of growth family member 3	Homo sapiens	119-123
20022955-0	2010	Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17.	Arginine	134-137	coactivator associated arginine methyltransferase 1	Homo sapiens	39-90
20022955-0	2010	Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17.	Arginine	134-137	coactivator associated arginine methyltransferase 1	Homo sapiens	92-97
33120256-6	2021	Mobile genetic elements (Intl1 and tnpA) showed significant correlations with the abundance of ARGs.	Arginine	95-99	Tn3 transposase	Escherichia coli	35-39
20022955-2	2010	Here, we report a novel specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1; also known as PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).	Arginine	69-77	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
20022955-2	2010	Here, we report a novel specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1; also known as PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).	Arginine	69-77	coactivator associated arginine methyltransferase 1	Homo sapiens	120-125
33443146-1	2021	The Ligand of Ate1 (Liat1) is a protein of unknown function that was originally discovered through its interaction with arginyl-tRNA protein transferase 1 (Ate1), a component of the Arg/N-degron pathway of protein degradation.	Arginine	182-185	RIKEN cDNA 1700016K19 gene	Mus musculus	20-25
19936946-8	2010	Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer.	Arginine	120-123	methylenetetrahydrofolate reductase	Homo sapiens	88-93
19936946-8	2010	Collectively, these exploratory data provide suggestive evidence for the association of MTHFR 429 Ala/ Ala and TCN2 259 Arg/Arg and CIMP status in colorectal cancer.	Arginine	124-127	methylenetetrahydrofolate reductase	Homo sapiens	88-93
33011338-6	2021	Lactose binding could be regained by replacing an arginine (Arg55) with asparagine, as shown in the crystal structures of two lactose-loaded Gal-16 mutants (R55N and R55N/H57R).	Arginine	50-58	galectin 16	Homo sapiens	141-147
20038105-0	2010	Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.	Arginine	94-102	furin, paired basic amino acid cleaving enzyme	Canis lupus familiaris	21-26
20038105-0	2010	Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.	Arginine	94-102	furin, paired basic amino acid cleaving enzyme	Canis lupus familiaris	31-36
20038105-2	2010	Furin and related furin-like PCs cleave their substrates at characteristic multibasic consensus sequences, preferentially after an arginine residue.	Arginine	131-139	furin, paired basic amino acid cleaving enzyme	Canis lupus familiaris	0-5
20038105-2	2010	Furin and related furin-like PCs cleave their substrates at characteristic multibasic consensus sequences, preferentially after an arginine residue.	Arginine	131-139	furin, paired basic amino acid cleaving enzyme	Canis lupus familiaris	18-23
20038105-3	2010	By incorporating decarboxylated arginine mimetics in the P1 position of substrate analogue peptidic inhibitors, we could identify highly potent furin inhibitors.	Arginine	32-40	furin, paired basic amino acid cleaving enzyme	Canis lupus familiaris	144-149
33096224-1	2021	Late-onset preeclampsia (LOPE) associates with reduced umbilical vein reactivity and endothelial nitric oxide synthase (eNOS) activity but increased human cationic amino acid (hCAT-1)-mediated L-arginine transport involving A2A adenosine receptor in the fetoplacental unit.	Arginine	193-203	solute carrier family 7 member 1	Homo sapiens	176-182
19730990-6	2010	Herein, we report a novel mutation identified at nucleotide position 655, at codon 98 from CAT --&gt; CGT with ultimate replacement of amino acid Histidine by Arginine in cervical cancer cases.	Arginine	159-167	UDP glycosyltransferase 8	Homo sapiens	102-105
19843630-0	2010	Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKCalpha, in old male rats.	Arginine	7-15	protein kinase C, alpha	Rattus norvegicus	91-99
32386503-5	2021	In addition to benzodiazepine/GABAergic receptors, the neuropharmacological properties of beta-CBP may be related to inhibition of nitric oxide synthesis, since pre-treatment with L-arginine (500- 750 mg/kg) reversed significantly the anxiolytic, antidepressant and anticonvulsant activities of beta-CBP.	Arginine	180-190	CREB binding protein	Mus musculus	95-98
21189691-6	2010	Sam68 frequently contains post-translational modifications including serine/threonine, tyrosine phosphorylation, lysine acetylation, arginine methylation and sumoylation.	Arginine	133-141	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
32386503-5	2021	In addition to benzodiazepine/GABAergic receptors, the neuropharmacological properties of beta-CBP may be related to inhibition of nitric oxide synthesis, since pre-treatment with L-arginine (500- 750 mg/kg) reversed significantly the anxiolytic, antidepressant and anticonvulsant activities of beta-CBP.	Arginine	180-190	CREB binding protein	Mus musculus	300-303
32891986-14	2021	Maternal dietary L-Arg supplementation significantly improved the expression of CPS1 gene, OTC gene (1.16%, 1.35%, and 1.55%), and ASS gene (1.35% and 1.55%) in the liver (P < 0.05), and also enhanced the CPS1 gene (except 1.35%) and OTC gene (1.55% and 1.74%) expression in the breast muscle (P < 0.05).	Arginine	17-22	ornithine carbamoyltransferase	Gallus gallus	91-94
20532736-4	2010	At least one of these functions, regulation of arginine biosynthesis by controlling the key enzyme N-acetyl-L: -glutamate kinase (NAGK), was transmitted by the ancestral cyanobacterium, which gave rise to chloroplasts, into the eukaryotic domain and was conserved during the evolution of planta.	Arginine	47-55	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	99-128
20532736-4	2010	At least one of these functions, regulation of arginine biosynthesis by controlling the key enzyme N-acetyl-L: -glutamate kinase (NAGK), was transmitted by the ancestral cyanobacterium, which gave rise to chloroplasts, into the eukaryotic domain and was conserved during the evolution of planta.	Arginine	47-55	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	130-134
32891986-14	2021	Maternal dietary L-Arg supplementation significantly improved the expression of CPS1 gene, OTC gene (1.16%, 1.35%, and 1.55%), and ASS gene (1.35% and 1.55%) in the liver (P < 0.05), and also enhanced the CPS1 gene (except 1.35%) and OTC gene (1.55% and 1.74%) expression in the breast muscle (P < 0.05).	Arginine	17-22	ornithine carbamoyltransferase	Gallus gallus	234-237
33129903-3	2021	This study was aimed at developing an injectable nanocurcumin and arginine incorporated chitosan hydrogel (nC/R) that can prevent hypoxia induced endothelial damage.	Arginine	66-74	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	107-111
19906948-1	2010	The kidney is a major site of arginine synthesis where citrulline is converted to arginine via argininosuccinate synthase (ASS) and lyase (ASL).	Arginine	30-38	argininosuccinate lyase	Homo sapiens	139-142
19906948-1	2010	The kidney is a major site of arginine synthesis where citrulline is converted to arginine via argininosuccinate synthase (ASS) and lyase (ASL).	Arginine	82-90	argininosuccinate lyase	Homo sapiens	139-142
19906948-12	2010	The fall in arginine production in 5/6 A/I was due to an early loss of ASS and ASL conversion of citrulline, which combined with a later reduction in citrulline uptake.	Arginine	12-20	argininosuccinate lyase	Homo sapiens	79-82
33129903-6	2021	The release of curucmin and arginine from the nC/R was found to be higher at acidic pH, which predominates in an ischemic site.	Arginine	28-36	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	46-50
33129903-10	2021	Therefore, nC/R hydrogel could effectively deliver both curcumin and arginine and therapeutically reduce the effect of hypoxia induced endothelial dysfunction.	Arginine	69-77	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	11-15
33162067-8	2021	In addition, activation of GCN2 as measured by increased phosphorylation of eIF2alpha Ser51 during the deprivation of Arg, Leu, and Lys combined and of Arg alone was sustained for up to 8 h of deprivation.	Arginine	118-121	eukaryotic translation initiation factor 2A	Bos taurus	76-85
33162067-8	2021	In addition, activation of GCN2 as measured by increased phosphorylation of eIF2alpha Ser51 during the deprivation of Arg, Leu, and Lys combined and of Arg alone was sustained for up to 8 h of deprivation.	Arginine	152-155	eukaryotic translation initiation factor 2A	Bos taurus	76-85
19913501-4	2010	In our current study, we show that the protein arginine methyltransferase 1 (PRMT1) is a cellular mediator of the arginine methylation of ICP27 RGG-box.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	77-82
19913501-5	2010	We generated arginine substitution mutants in this domain and examined which arginine residues are required for methylation by PRMT1.	Arginine	77-85	protein arginine methyltransferase 1	Homo sapiens	127-132
32605929-4	2021	All three JMJD1 proteins are capable of removing di- and monomethyl marks from lysine 9 on histone H3 and might also demethylate histone H4 on arginine 3 and non-histone proteins.	Arginine	143-151	lysine (K)-specific demethylase 3A	Mus musculus	10-15
19950230-8	2010	In conclusion, the substitution of amino aa70 of Arg for Gln in patients infected with HCV-1b increases with age, and it is associated with severe liver disease accompanied by elevated AST and gamma-GTP levels, as well as the development of hepatocellular carcinoma.	Arginine	49-52	inactive glutathione hydrolase 2	Homo sapiens	193-202
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	165-168	coactivator associated arginine methyltransferase 1	Homo sapiens	0-51
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	5-6	brain-derived neurotrophic factor	Rattus norvegicus	178-182
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	165-168	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
33396450-6	2020	PEDF-R- and LR-knocked-down cells demonstrated a markedly attenuated expression of anti-apoptotic Bcl-2 family members (Bcl-2, Bcl-xL) and neuroprotective mediators (PEDF, VEGF, BDNF) suggesting that both PEDF-R and LR mediate pro-survival effects of PEDF on RGC.	Arginine	13-14	brain-derived neurotrophic factor	Rattus norvegicus	178-182
33302555-3	2020	In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y+L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing.	Arginine	264-274	solute carrier family 7 member 1	Homo sapiens	53-57
19850051-4	2009	We have demonstrated that a highly conserved Arg residue on loop 1 of RHBDL2 plays a critical role in the activation of the proenzyme.	Arginine	45-48	rhomboid like 2	Homo sapiens	70-76
33302555-3	2020	In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y+L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing.	Arginine	264-274	solute carrier family 7 member 1	Homo sapiens	68-74
33302555-3	2020	In this respect the cationic amino acid transporters CAT1 and CAT2 (SLC7A1 and SLC7A2) and the system y+L amino acid transporters (SLC7A6 and SLC7A7) have been most extensively investigated, so far, but the number of transporters shown to mediate the transport of L-arginine and its derivatives is constantly increasing.	Arginine	264-274	solute carrier family 7 member 6	Homo sapiens	131-137
33229537-5	2020	2) Glucocorticoid receptor (GR), an immunity-modulating transcription factor (TF), is up-regulated in 2-KO cells and also physically binds to UBR1, strongly suggesting that GR is a physiological substrate of the Arg/N-degron pathway.	Arginine	212-215	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	142-146
20641584-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3 and alphavbeta5.	Arginine	21-24	vitronectin	Homo sapiens	121-132
19833725-6	2009	Point mutation of Tyr(183) or Arg(486) in the SH2 domain of 3BP2 diminished BCR-mediated tyrosine phosphorylation of 3BP2.	Arginine	30-33	SH3 domain binding protein 2	Homo sapiens	60-64
19833725-6	2009	Point mutation of Tyr(183) or Arg(486) in the SH2 domain of 3BP2 diminished BCR-mediated tyrosine phosphorylation of 3BP2.	Arginine	30-33	SH3 domain binding protein 2	Homo sapiens	117-121
33109615-5	2020	By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Galpha13 (encoded by GNA13) as potent activators of oncogenic signaling.	Arginine	120-123	G protein subunit alpha 13	Homo sapiens	131-139
19189375-2	2009	These activities are probably due to ECP"s ability to interact with and disrupt membranes and depend on two Trp, 19 Arg, and possibly an extremely high conformational stability.	Arginine	116-119	ribonuclease A family member 3	Homo sapiens	37-40
33109615-5	2020	By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associated hotspot mutations in Arg-200 of Galpha13 (encoded by GNA13) as potent activators of oncogenic signaling.	Arginine	120-123	G protein subunit alpha 13	Homo sapiens	152-157
33109615-8	2020	Among the G12/13 pathway alterations were mutations in Arg-200 of Galpha13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-depedent (SRE.L) transcriptional activity.	Arginine	55-58	G protein subunit alpha 13	Homo sapiens	10-16
33109615-8	2020	Among the G12/13 pathway alterations were mutations in Arg-200 of Galpha13, which we validated to promote YAP/TAZ-dependent (TEAD) and MRTF-A/B-depedent (SRE.L) transcriptional activity.	Arginine	55-58	G protein subunit alpha 13	Homo sapiens	66-74
19643181-0	2009	The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation.	Arginine	72-80	protein arginine methyltransferase 1	Homo sapiens	49-54
33051382-8	2020	Our results demonstrated that miR-1291 was effective to sensitize PC cells to arginine deprivation treatment and chemotherapy through targeting ASS1- and GLUT1-mediated arginolysis and glycolysis, respectively, which may provide insights into understanding miRNA signaling underlying cancer cell metabolism and development of new strategies for the treatment of lethal PC.	Arginine	78-86	solute carrier family 2 member 1	Homo sapiens	154-159
33215568-5	2020	The expression of the Bcl-2 gene was upregulated and the expression of Bax, caspase-3, and PARP gene were downregulated when L-arginine was added to the cultured cells.	Arginine	125-135	BCL2-associated X protein	Mus musculus	71-74
19839650-4	2009	Comparison of its specificity profile with that of the SHIP1 SH2 domain showed that the two SH2 domains have similar specificities, both recognizing pY peptides of the consensus sequence pY[S/Y][L/Y/M][L/M/I/V], although there are also subtle differences such as the tolerance of an arginine at the pY + 1 position by the SHIP2 but not SHIP1 SH2 domain.	Arginine	283-291	inositol polyphosphate-5-phosphatase D	Homo sapiens	55-60
33215568-5	2020	The expression of the Bcl-2 gene was upregulated and the expression of Bax, caspase-3, and PARP gene were downregulated when L-arginine was added to the cultured cells.	Arginine	125-135	caspase 3	Mus musculus	76-85
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	82-90	adrenoceptor beta 2	Homo sapiens	130-155
33215568-5	2020	The expression of the Bcl-2 gene was upregulated and the expression of Bax, caspase-3, and PARP gene were downregulated when L-arginine was added to the cultured cells.	Arginine	125-135	poly (ADP-ribose) polymerase family, member 1	Mus musculus	91-95
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	161-164	adrenoceptor beta 2	Homo sapiens	130-155
19932356-1	2009	BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly).	Arginine	165-168	adrenoceptor beta 2	Homo sapiens	130-155
32840935-3	2020	RBM20 mutations are especially localized in exons 9 and 11 including the highly conserved arginine and serine rich domain (RS domain).	Arginine	90-98	RNA binding motif protein 20	Homo sapiens	0-5
19924249-7	2009	By Northwestern analysis, we showed that IE4 is able to bind RNA through its arginine-rich region and in immunoprecipitation experiments the presence of RNA stabilizes complexes containing IE4 and the cellular export factors TAP/NXF1 and Aly/REF since the interactions are RNase-sensitive.	Arginine	77-85	nuclear RNA export factor 1	Homo sapiens	225-228
19924249-7	2009	By Northwestern analysis, we showed that IE4 is able to bind RNA through its arginine-rich region and in immunoprecipitation experiments the presence of RNA stabilizes complexes containing IE4 and the cellular export factors TAP/NXF1 and Aly/REF since the interactions are RNase-sensitive.	Arginine	77-85	nuclear RNA export factor 1	Homo sapiens	229-233
19924249-7	2009	By Northwestern analysis, we showed that IE4 is able to bind RNA through its arginine-rich region and in immunoprecipitation experiments the presence of RNA stabilizes complexes containing IE4 and the cellular export factors TAP/NXF1 and Aly/REF since the interactions are RNase-sensitive.	Arginine	77-85	Aly/REF export factor	Homo sapiens	238-245
19878914-9	2009	An electrophoretic mobility-shift assay showed that essential splicing factors, serine/arginine-rich splicing factors SFRS1 and SFRS9, bind to (UGGAA)n in vitro.	Arginine	87-95	serine and arginine rich splicing factor 1	Homo sapiens	118-123
32955857-3	2020	Mechanistic studies show that the catalysis consists of a three-step reaction: the oxidation of NADPH to produce O2- via oxidase-like activity, the subsequent dismutation of O2- to H2O2 via SOD-like activity, followed by H2O2-mediated oxidation of L-arginine to produce NO via a non-enzymatic pathway.	Arginine	248-258	2,4-dienoyl-CoA reductase 1	Homo sapiens	96-101
19571258-5	2009	Bovine milk SPP1, ovine uterine SPP1, and recombinant wild-type, but not mutated, rat SPP1 promoted dose- and cation-dependent attachment of porcine trophectoderm and uterine luminal epithelial cells, which was markedly reduced in the presence of a linear Arg-Gly-Asp integrin-blocking peptide.	Arginine	256-259	secreted phosphoprotein 1	Bos taurus	12-16
32699135-5	2020	PRMT1 overexpression increased arginine methylation of HSPs of 70 kDa (HSP70); this methylation enhanced HSP70 binding and stabilization of BCL2 mRNA through AU-rich elements in 3"-untranslated region and consequentially increased BCL2 protein expression and protected cancer cells from apoptosis induced by cellular stresses and therapeutics.	Arginine	31-39	protein arginine methyltransferase 1	Homo sapiens	0-5
19754350-8	2009	Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28).	Arginine	0-3	X-ray repair cross complementing 1	Homo sapiens	25-30
19754350-8	2009	Arg-His-Arg haplotype of XRCC1 significantly enhanced the risk for hepatitis by 2.8-folds (p = 0.001), but not for HCC (odds ratio = 1.5; p = 0.28).	Arginine	8-11	X-ray repair cross complementing 1	Homo sapiens	25-30
32699135-5	2020	PRMT1 overexpression increased arginine methylation of HSPs of 70 kDa (HSP70); this methylation enhanced HSP70 binding and stabilization of BCL2 mRNA through AU-rich elements in 3"-untranslated region and consequentially increased BCL2 protein expression and protected cancer cells from apoptosis induced by cellular stresses and therapeutics.	Arginine	31-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	55-69
32699135-6	2020	RNA binding and regulation function of HSP70 was involved in pancreatic cancer drug resistance and was dependent on protein arginine methylation.	Arginine	124-132	heat shock protein family A (Hsp70) member 4	Homo sapiens	39-44
19726514-4	2009	Truncation to the arginine at residue 694 resulted in an Env complex that was secreted from the cells.	Arginine	18-26	endogenous retrovirus group K member 20	Homo sapiens	57-60
33090265-11	2020	Furthermore, positive correlations were observed when comparing plasma DAO activity with histidine, proline, cystine, arginine, and glutamine concentrations.	Arginine	118-126	D-amino acid oxidase	Bos taurus	71-74
19726520-0	2009	Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.	Arginine	0-8	Tat	Human immunodeficiency virus 1	84-87
19726520-4	2009	Tat stabilization depends on the catalytic activity of PRMT6 and requires arginine methylation within the Tat basic domain.	Arginine	74-82	Tat	Human immunodeficiency virus 1	106-109
19726520-7	2009	Our data reveal a proteasome-dependent Tat degradation pathway that is inhibited by arginine methylation.	Arginine	84-92	Tat	Human immunodeficiency virus 1	39-42
32690227-0	2020	Retraction notice to "The antidepressant effects of L-arginine on chronic mild stress-induced depression by augmenting the expression of brain-derived neurotrophic factor in rats" [Brain Res.	Arginine	52-62	brain-derived neurotrophic factor	Rattus norvegicus	137-170
19247656-3	2009	RESULTS: Among the five studied polymorphisms, p53 codon 72 Pro/Pro, GSTP1 codon 105 Ile/Ile, and XRCC1 codon 399 Gln/Gln + Arg/Gln were associated with poor relapse-free survival and overall survival (P &lt; 0.05); and the prognostic effect was retained in the Cox multivariate analysis.	Arginine	124-127	X-ray repair cross complementing 1	Homo sapiens	98-103
19485892-9	2009	Recent evidences suggest that insulin blocks the stimulatory effect of D-glucose on L-arginine transport by reducing the transcriptional activity of SLC7A1 via Sp1-, NFkappaB- and ROS-dependent mechanisms.	Arginine	84-94	solute carrier family 7 member 1	Homo sapiens	149-155
19684136-0	2009	The multifaceted proteins MvaT and MvaU, members of the H-NS family, control arginine metabolism, pyocyanin synthesis, and prophage activation in Pseudomonas aeruginosa PAO1.	Arginine	77-85	transcriptional regulator MvaT	Pseudomonas aeruginosa PAO1	26-30
19684136-1	2009	The MvaT and MvaU proteins belonging to the H-NS family were identified as DNA-binding proteins that interact with the regulatory region of the aotJQMOP-argR operon for arginine uptake and regulation.	Arginine	169-177	transcriptional regulator MvaT	Pseudomonas aeruginosa PAO1	4-8
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Arginine	20-28	parathyroid hormone 1 receptor	Sus scrofa	81-86
19608645-9	2009	Mutating the lysine-arginine-lysine motif within the juxtamembrane region of the PTH1R C-terminal tail to alanines markedly disrupts interactions with the band 4.1, ezrin, radixin, domain of ezrin both in vitro and within cells.	Arginine	20-28	LOC100153898	Sus scrofa	191-196
19562367-0	2009	Arginine transport in human erythroid cells: discrimination of CAT1 and 4F2hc/y+LAT2 roles.	Arginine	0-8	transient receptor potential cation channel subfamily V member 6	Homo sapiens	63-67
19586904-9	2009	The results presented above led us to propose that NOS mediates UV-induced eIF2alpha phosphorylation by activation of both PERK and GCN2 via oxidative stress and l-arginine starvation signaling pathways.	Arginine	162-172	eukaryotic translation initiation factor 2A	Homo sapiens	75-84
19553338-0	2009	Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection.	Arginine	0-8	Aly/REF export factor	Homo sapiens	104-111
19553338-2	2009	Arginine methylation can regulate protein-protein interactions; therefore, we examined the effect of hypomethylation on ICP27"s interactions with cellular proteins SRPK1 and Aly/REF, which bind to ICP27 through the RGG box region.	Arginine	0-8	Aly/REF export factor	Homo sapiens	174-181
19628051-3	2009	Individuals bearing the XRCC1 399Gln variant allele showed significant increases in TM values in all subjects or in referent subgroups stratified by age or smoking status except in the current smokers group; in contrast, the TM values of individuals bearing the XRCC1 194Trp variant allele were significantly lower than those of individuals bearing wild-type Arg/Arg genotypes.	Arginine	359-362	X-ray repair cross complementing 1	Homo sapiens	24-29
19628051-3	2009	Individuals bearing the XRCC1 399Gln variant allele showed significant increases in TM values in all subjects or in referent subgroups stratified by age or smoking status except in the current smokers group; in contrast, the TM values of individuals bearing the XRCC1 194Trp variant allele were significantly lower than those of individuals bearing wild-type Arg/Arg genotypes.	Arginine	363-366	X-ray repair cross complementing 1	Homo sapiens	24-29
19051060-5	2009	Variant genotypes XRCC1 Arg/Gln or Gln/Gln and XPD Lys/Gln or Gln/Gln increased both familial and sporadic breast cancer susceptibility.	Arginine	24-27	X-ray repair cross complementing 1	Homo sapiens	18-23
19404000-4	2009	On the other hand, PGF stimulated the expression of inducible NOS (iNOS) mRNA (P&lt;0.05) and protein (P&lt;0.05) at 2 h, but not at 6 and 24 h. By observing the conversion of [(3)C](L)-arginine to [(3)C](L)-citrulline, we found that PGF stimulated NOS activity in cultured LECs at 2 h (P&lt;0.05).	Arginine	184-194	nitric oxide synthase 2	Bos taurus	67-71
19460357-0	2009	Arginine methylation of ribosomal protein S3 affects ribosome assembly.	Arginine	0-8	ribosomal protein S3	Homo sapiens	24-44
19460357-2	2009	We recently found that the arginine residue(s) of rpS3 are methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	27-35	ribosomal protein S3	Homo sapiens	50-54
19460357-2	2009	We recently found that the arginine residue(s) of rpS3 are methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	27-35	protein arginine methyltransferase 1	Homo sapiens	73-109
19460357-2	2009	We recently found that the arginine residue(s) of rpS3 are methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	27-35	protein arginine methyltransferase 1	Homo sapiens	111-116
19460357-3	2009	In this paper, we confirmed the arginine methylation of rpS3 protein both in vitro and in vivo.	Arginine	32-40	ribosomal protein S3	Homo sapiens	56-60
19460357-6	2009	Our results clearly show that arginine methylation of rpS3 plays a critical role in its import into the nucleolus, as well as in small subunit assembly of the ribosome.	Arginine	30-38	ribosomal protein S3	Homo sapiens	54-58
19378296-9	2009	Its docked pose in the RXRalpha ligand binding domain suggests that binding is stabilized by interactions of its carboxylate group with arginine 316, its indoles with cysteines 269 and 432, and its 1-methyl groups with hydrophobic residues lining the binding pocket.	Arginine	136-144	retinoid X receptor alpha	Homo sapiens	23-31
19639563-7	2009	The oxidation of some of the oxidation-prone proteins under oxidative stress such as carbonic anhydrase 3 decreased with increased levels of arginine methylation, whereas normal levels of protein oxidation were recovered as arginine methylation subsided.	Arginine	141-149	carbonic anhydrase 3	Rattus norvegicus	85-105
19373110-8	2009	RESULTS: The odds ratio for the presence of hypertension in individuals having the Gly/Gly genotype of ADRB2 compared with those having the other genotypes (Arg/Arg and Arg/Gly) was 2.87.	Arginine	161-164	adrenoceptor beta 2	Homo sapiens	103-108
19373110-8	2009	RESULTS: The odds ratio for the presence of hypertension in individuals having the Gly/Gly genotype of ADRB2 compared with those having the other genotypes (Arg/Arg and Arg/Gly) was 2.87.	Arginine	161-164	adrenoceptor beta 2	Homo sapiens	103-108
19454603-7	2009	Nuclear localization of Npl3 also requires specific RG sequences, yet heterologous RG domains allow similar modulation of Npl3 transport by arginine methylation.	Arginine	140-148	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	122-126
19501907-11	2009	Thus, IUGR- and hypoxia-reduced l-arginine transport could result from increased PKCalpha, but reduced eNOS activity leading to a lower hCAT-1 expression in HUVEC.	Arginine	32-42	solute carrier family 7 member 1	Homo sapiens	136-142
19254764-4	2009	This method excludes the use of L-arginine, which is expensive, and can be used to prepare a large quantity of recombinant DAF for therapeutic studies.	Arginine	32-42	CD55 molecule (Cromer blood group)	Homo sapiens	123-126
19460869-6	2009	We show that AtTadA is imported into chloroplasts in vivo and demonstrate that the in vitro translated protein triggers A-to-I editing in the anticodon of the plastid tRNA-Arg(ACG).	Arginine	172-175	tRNA arginine adenosine deaminase	Arabidopsis thaliana	13-19
19460869-7	2009	Suppression of AtTadA gene expression in transgenic Arabidopsis plants by RNAi results in reduced A-to-I editing in the chloroplast tRNA-Arg(ACG).	Arginine	137-140	tRNA arginine adenosine deaminase	Arabidopsis thaliana	15-21
19563645-9	2009	Moreover, the genotype with the Gln allele(Arg/Gln+Gln/Gln) at codon 399, but not codon at 194, presented a significantly higher level of XRCC1 protein expression than that with Arg/Arg genotype (F = 2.699, p = 0.009).	Arginine	43-46	X-ray repair cross complementing 1	Homo sapiens	138-143
19473029-0	2009	Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.	Arginine	16-24	melanocortin 4 receptor	Homo sapiens	128-151
32424476-15	2020	These data suggest that cilostazol protects against L-arginine-induced AP, which may be related to an increase in cGMP, cAMP, and upregulation of HO-1 with subsequent anti-inflammatory and antioxidant properties.	Arginine	52-62	heme oxygenase 1	Rattus norvegicus	146-150
19395377-7	2009	IaI heavy chains contain von Willebrand A domains that can bind the arginine-glycine-aspartate domain of vitronectin.	Arginine	68-76	vitronectin	Mus musculus	105-116
19395377-9	2009	We show that IaI binds vitronectin at the arginine-glycine-aspartate site, thereby promoting epithelial adhesion and migration in vitro.	Arginine	42-50	vitronectin	Mus musculus	23-34
33052246-7	2020	Functional SLC14A1 prevented the accumulation of arginine and urea, enhanced mitochondrial fusion and aerobic respiration, inhibited glycolysis by altering the expression levels of several related proteins and sensitized arginine-deprivation treatment in ASS1-deficient UC-derived cells.	Arginine	49-57	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	11-18
19356730-6	2009	The effect of vasopressin was completely blocked by pretreatment with the vasopressin V(1A) receptor antagonist d(CH2)5Tyr(Me)(2),Arg(8)-vasopressin.	Arginine	130-133	arginine vasopressin receptor 1A	Rattus norvegicus	74-100
33052246-7	2020	Functional SLC14A1 prevented the accumulation of arginine and urea, enhanced mitochondrial fusion and aerobic respiration, inhibited glycolysis by altering the expression levels of several related proteins and sensitized arginine-deprivation treatment in ASS1-deficient UC-derived cells.	Arginine	221-229	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	11-18
33052246-8	2020	In vitro and in vivo, SLC14A1 inhibited the mTOR signaling pathway and subsequently tumorigenesis, supported by reduced arginine concentrations in vitro.	Arginine	120-128	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	22-29
33052246-11	2020	Total and membranous SLC14A1 prevents urea and arginine accumulation via the mTOR signaling pathway.	Arginine	47-55	solute carrier family 14 member 1 (Kidd blood group)	Homo sapiens	21-28
19503814-5	2009	In order to characterize the nuclear shuttling activity of Atx3, we performed yeast nuclear import assays and found that Atx3 is actively imported into the nucleus, by means of a classical nuclear localizing sequence formed by a cluster of lysine and arginine residues.	Arginine	251-259	ataxin 3	Homo sapiens	59-63
19503814-5	2009	In order to characterize the nuclear shuttling activity of Atx3, we performed yeast nuclear import assays and found that Atx3 is actively imported into the nucleus, by means of a classical nuclear localizing sequence formed by a cluster of lysine and arginine residues.	Arginine	251-259	ataxin 3	Homo sapiens	121-125
33013448-6	2020	The M240 residue is conserved among human Kv7.2-5 and lies between the two arginines (R5 and R6) closest to the intracellular side of the voltage-sensing S4 transmembrane segment.	Arginine	75-84	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	42-49
32883247-3	2020	Patients with Arginine:Glycine Amidino-Transferase deficiency (AGAT-d), due to the deficit of the first enzyme involved in Cr synthesis, are at a disadvantage due to their failure to synthesize Cr and their dependence on external intake, in contrast to normal subjects, where changes in Cr biosynthesis supply their needs.	Arginine	14-22	glycine amidinotransferase	Homo sapiens	63-67
19463982-7	2009	A structural model of human EMG1 suggested that the D86 residue formed a salt bridge with arginine 84 that would be disrupted by the glycine (G) substitution.	Arginine	90-98	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	28-32
19266243-11	2009	In XRCC1 Arg399Gln polymorphism, significant differences in frequencies of Gln/Gln and Arg/Gln genotypes conferred significantly low risk for GBC (OR = 0.62; 95%CI = 0.39-0.97 and OR = 0.37; 95%CI = 0.19-0.71 respectively).	Arginine	9-12	X-ray repair cross complementing 1	Homo sapiens	3-8
19266243-13	2009	The carriers of Arg-Gln haplotype consisting of 194Arg and 399Gln alleles of XRCC1 were also at significant low risk for GBC (OR = 0.59, 95%CI = 0.42-0.82).	Arginine	16-19	X-ray repair cross complementing 1	Homo sapiens	77-82
32255561-6	2020	RESULTS: Autocitrullination of PAD2 and PAD4 was detected in 16 (48%) of 33 arginine residues and 7 (26%) of 27 arginine residues, respectively.	Arginine	76-84	peptidyl arginine deiminase 2	Homo sapiens	31-35
32255561-6	2020	RESULTS: Autocitrullination of PAD2 and PAD4 was detected in 16 (48%) of 33 arginine residues and 7 (26%) of 27 arginine residues, respectively.	Arginine	112-120	peptidyl arginine deiminase 2	Homo sapiens	31-35
32166393-1	2020	The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types.	Arginine	150-158	solute carrier family 6 member 14	Homo sapiens	4-37
19201771-8	2009	RESULTS: It was found that administering caerulein and L-arginine to wild-type mice resulted in acute pancreatitis (as assessed by hyperamylasaemia, oedema, increased pancreatic MPO activity, and pancreatic necrosis) and associated lung injury.	Arginine	55-65	myeloperoxidase	Mus musculus	178-181
32166393-1	2020	The solute carrier family 6 member 14 (SLC6A14) protein imports and concentrates all neutral amino acids as well as the two cationic acids lysine and arginine into the cytoplasm of different cell types.	Arginine	150-158	solute carrier family 6 member 14	Homo sapiens	39-46
32844749-0	2020	Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	0-8	protein arginine methyltransferase 7	Homo sapiens	34-39
19168337-0	2009	l-Arginine supplementation enhances eNOS expression in experimental model of hypercholesterolemic rabbits aorta.	Arginine	0-10	nitric oxide synthase, endothelial	Oryctolagus cuniculus	36-40
19168337-13	2009	The results also indicated that eNOS expression (intensity) in aortas was significantly higher in l-arginine-treated group (group 1: 13.62+-2.7 and group 2: 21.77+-2.8; p&lt;0.05), but no significant difference was observed for iNOS expression between the groups.	Arginine	98-108	nitric oxide synthase, endothelial	Oryctolagus cuniculus	32-36
19168337-15	2009	l-Arginine in drinking water has a beneficial effect in the enhancement of eNOS protein expression.	Arginine	0-10	nitric oxide synthase, endothelial	Oryctolagus cuniculus	75-79
19238562-5	2009	The mapping of deletion mutants of atSR45a proteins revealed that the C-terminal arginine/serine-rich (RS) domain of atSR45a proteins are required for the interaction with U1-70K, U2AF(35)b, atSR45, atSCL28, PRP38-like protein, and themselves, and the N-terminal RS domain enhances the interaction efficiency.	Arginine	81-89	pre-mRNA processing factor 38A	Homo sapiens	208-213
32402966-4	2020	ARG abundances of these samples were obtained by searching the metagenomic sequences against the antibiotic resistance gene database and the copies of ARGs per copy of the 16S rRNA gene at different levels were assessed.	Arginine	0-3	serpin family A member 2 (gene/pseudogene)	Homo sapiens	151-155
19309309-6	2009	A GST (glutathione transferase) pulldown assay using different deletion mutants revealed that the RGG (Arg-Gly-Gly) region of RHA was responsible for the interaction with beta-actin, and this dominant-negative mutant reduced the recruitment of Pol II (RNA polymerase II) into PICs.	Arginine	103-106	POTE ankyrin domain family member F	Homo sapiens	171-181
19414610-0	2009	Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.	Arginine	0-3	cortactin	Homo sapiens	19-28
19414610-2	2009	In this study, we show that interactions between Arg and the Arp2/3 complex regulator cortactin are essential to mediate actin-based cell edge protrusion during fibroblast adhesion to fibronectin.	Arginine	49-52	cortactin	Homo sapiens	86-95
19414610-3	2009	Arg-deficient and cortactin knockdown fibroblasts exhibit similar defects in adhesion-dependent cell edge protrusion, which can be restored via reexpression of Arg and cortactin.	Arginine	0-3	cortactin	Homo sapiens	168-177
19414610-3	2009	Arg-deficient and cortactin knockdown fibroblasts exhibit similar defects in adhesion-dependent cell edge protrusion, which can be restored via reexpression of Arg and cortactin.	Arginine	160-163	cortactin	Homo sapiens	18-27
19414610-4	2009	Arg interacts with cortactin via both binding and catalytic events.	Arginine	0-3	cortactin	Homo sapiens	19-28
19414610-5	2009	The cortactin Src homology (SH) 3 domain binds to a Pro-rich motif in the Arg C terminus.	Arginine	74-77	cortactin	Homo sapiens	4-13
19414610-6	2009	Arg mediates adhesion-dependent phosphorylation of cortactin, creating an additional binding site for the Arg SH2 domain.	Arginine	0-3	cortactin	Homo sapiens	51-60
19414610-6	2009	Arg mediates adhesion-dependent phosphorylation of cortactin, creating an additional binding site for the Arg SH2 domain.	Arginine	106-109	cortactin	Homo sapiens	51-60
19130170-3	2009	In addition, glutamine and arginine stimulate the mitogen-activated protein kinase and mammalian target of rapamycin (mTOR)/p70 (s6) kinase pathways, respectively, to enhance mucosal cell migration and restitution.	Arginine	27-35	annexin A6	Homo sapiens	124-127
18946634-6	2009	Allelic frequencies in wild type of XRCC1 C26304T were 91.1% C(Arg); G27466A 62.9% G(Arg); G23591A 60.3% G(Arg); APE1 T2197G 75.1% T(Asp) and XPD A35931C 71.8% A(Lys).	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	36-41
18946634-6	2009	Allelic frequencies in wild type of XRCC1 C26304T were 91.1% C(Arg); G27466A 62.9% G(Arg); G23591A 60.3% G(Arg); APE1 T2197G 75.1% T(Asp) and XPD A35931C 71.8% A(Lys).	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	36-41
19366727-4	2009	Using polysome analysis and RNA-binding assays, we show that elevated levels of translation depend on an interaction between a triple arginine motif in LC3 and the AU-rich element in Fn1 mRNA.	Arginine	134-142	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	152-155
19586842-3	2009	A missense mutation, c.1273G>A, was identified in exon 14 of the MYH7 gene in 4 members of the Chinese HCM family, which resulted a glycine (Gly) to arginine (Arg) exchange at amino acid residue 425.	Arginine	149-157	myosin heavy chain 7	Homo sapiens	65-69
19586842-3	2009	A missense mutation, c.1273G>A, was identified in exon 14 of the MYH7 gene in 4 members of the Chinese HCM family, which resulted a glycine (Gly) to arginine (Arg) exchange at amino acid residue 425.	Arginine	159-162	myosin heavy chain 7	Homo sapiens	65-69
19430548-12	2009	CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy.	Arginine	40-43	adrenoceptor beta 2	Homo sapiens	72-77
19430548-12	2009	CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy.	Arginine	40-43	adrenoceptor beta 2	Homo sapiens	204-209
19430548-12	2009	CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy.	Arginine	44-47	adrenoceptor beta 2	Homo sapiens	72-77
19430548-12	2009	CONCLUSION: Asthmatic patients with the Arg/Arg genotype at codon 16 of ADRB2 achieve better asthma control with long-term regular use of combined budesonide and formoterol treatment, suggesting that the ADRB2 genotype may dictate choice of treatment strategy.	Arginine	44-47	adrenoceptor beta 2	Homo sapiens	204-209
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	109-112	coagulation factor X	Homo sapiens	58-67
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	118-121	coagulation factor X	Homo sapiens	58-67
19240027-1	2009	The procofactor, factor VIII, is activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg-1689.	Arginine	118-121	coagulation factor X	Homo sapiens	58-67
19124016-9	2009	Our findings demonstrate that arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function.	Arginine	30-38	TATA-box binding protein associated factor 15	Homo sapiens	54-59
19124016-9	2009	Our findings demonstrate that arginine methylation of TAF15 by PRMT1 is a crucial event determining its proper localization and gene regulatory function.	Arginine	30-38	protein arginine methyltransferase 1	Homo sapiens	63-68
19441602-1	2009	BACKGROUND: Beta 2-Adrenergic receptor polymorphisms occurring at amino acid positions 16 (arginine/glycine) and 27 (glutamine/glutamic acid) are known to be functionally relevant.	Arginine	91-99	adrenoceptor beta 2	Homo sapiens	12-38
18997081-8	2009	However, incubation of bovine preadipocytes with arginine, a biological precursor of NO, strongly promotes differentiation in concert with increased SCD expression.	Arginine	49-57	stearoyl-CoA desaturase	Bos taurus	149-152
19158082-1	2009	Asymmetric dimethylation of arginine residues is a common posttranslational modification of proteins carried out by type I protein arginine methyltransferases, including PRMT1 and -3.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	170-182
19158082-2	2009	We report that the consecutive transfer of two methyl groups to a single arginine side chain by PRMT1 and -3 occurs in a distributive manner, i.e. with intermittent release of the monomethylated intermediate.	Arginine	73-81	protein arginine methyltransferase 1	Homo sapiens	96-108
19158082-5	2009	PRMT1 also does not prefer substrates already containing one or more singly or doubly methylated arginine residues.	Arginine	97-105	protein arginine methyltransferase 1	Homo sapiens	0-5
19328069-5	2009	Lethality caused by mutating both residues to arginine is suppressed by the scc3, pds5, and rad61 mutants.	Arginine	46-54	Irr1p	Saccharomyces cerevisiae S288C	76-80
19328069-5	2009	Lethality caused by mutating both residues to arginine is suppressed by the scc3, pds5, and rad61 mutants.	Arginine	46-54	Pds5p	Saccharomyces cerevisiae S288C	82-86
19234205-7	2009	This was reflected by a switch in the enzymatic pathway for arginine metabolism from arginase to inducible NO synthase and the reduced expression of RELM-alpha and Ym1.	Arginine	60-68	chitinase-like 3	Mus musculus	164-167
19217439-2	2009	Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	84-92	argininosuccinate lyase	Homo sapiens	175-198
19217439-2	2009	Citrulline, which is formed as a by-product of the NOS reaction, can be recycled to arginine by the 2 enzymes acting in the urea cycle: argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL).	Arginine	84-92	argininosuccinate lyase	Homo sapiens	200-203
19178150-5	2009	In reactions with C1-INH, Arg-171 was the most critical residue contributing approximately 2-3-fold to heparin-mediated inhibition of CD-WT.	Arginine	26-29	serpin family G member 1	Homo sapiens	18-24
18983266-6	2009	Arg(333) and Lys(348) in the C-terminal tail of the beta2AR were identified as crucial determinants for Rab11 binding.	Arginine	0-3	adrenoceptor beta 2	Homo sapiens	52-59
19059699-5	2009	RESULTS: A novel mutation in the thrombopoietin (TPO) receptor Mpl in HLB219 mice caused a Cys--&gt;Arg substitution at codon 40 in the extracellular region of the receptor.	Arginine	100-103	thrombopoietin	Mus musculus	33-47
19059699-5	2009	RESULTS: A novel mutation in the thrombopoietin (TPO) receptor Mpl in HLB219 mice caused a Cys--&gt;Arg substitution at codon 40 in the extracellular region of the receptor.	Arginine	100-103	thrombopoietin	Mus musculus	49-52
19010776-5	2009	Mutation of Arg-150 in factor Xa, which interacts with the exosite residues in heparin-activated antithrombin, abrogated the ability of the engineered exosites in alpha1PI to promote factor Xa inhibition.	Arginine	12-15	coagulation factor X	Homo sapiens	23-32
19010776-5	2009	Mutation of Arg-150 in factor Xa, which interacts with the exosite residues in heparin-activated antithrombin, abrogated the ability of the engineered exosites in alpha1PI to promote factor Xa inhibition.	Arginine	12-15	coagulation factor X	Homo sapiens	183-192
18984580-0	2009	Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.	Arginine	23-31	prostaglandin E synthase	Homo sapiens	35-72
19557313-3	2009	In this study, we found that SFRS9 is a target for PRMT1-mediated arginine methylation in vitro, and that it is immunoprecipitated from HEK-293 lysates by antibodies that recognize both mono- and dimethylated arginines.	Arginine	66-74	protein arginine methyltransferase 1	Homo sapiens	51-56
19136629-0	2009	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	0-5
19136629-0	2009	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	signal transducer and activator of transcription 1	Homo sapiens	55-60
19136629-4	2009	PIAS1 is arginine methylated by PRMT1 in vitro as well as in vivo upon IFN treatment.	Arginine	9-17	protein arginine methyltransferase 1	Homo sapiens	32-37
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	protein arginine methyltransferase 1	Homo sapiens	155-160
19042972-3	2009	Previously, REX1 was shown to be involved in processing the 3" ends of 5S rRNA and the dimeric tRNA(Arg)-tRNA(Asp).	Arginine	100-103	Rnh70p	Saccharomyces cerevisiae S288C	12-16
18945674-4	2008	Inhibition, depletion, or knockout of the Abl family kinases, Abl and Arg, resulted in a dramatic reduction in the intracellular activities of the lysosomal glycosidases alpha-galactosidase, alpha-mannosidase and neuraminidase.	Arginine	70-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	42-45
32817790-6	2020	These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis (sterol regulatory element-binding protein-1, acetyl-CoA carboxylase alpha, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid beta-oxidation (carnitine palmitoyltransferase 1alpha and peroxisome proliferator-activated receptor alpha).	Arginine	17-25	fatty acid synthase	Oreochromis niloticus	211-230
19064668-8	2008	Addition of arginine to wild-type cells leads to a similar redistribution and increased turnover of Can1.	Arginine	12-20	arginine permease CAN1	Saccharomyces cerevisiae S288C	100-104
32585103-2	2020	The main strategies of PRMT7 in reducing the activation barrier for methyl transfer that are found in this study include (1) formation of reactive (near attack) conformations for the substrate Arg, (2) strengthening the active-site interactions at the transition state, and (3) generation of more effective nucleophiles by changing charge distributions on the target Arg through active-site interactions.	Arginine	193-196	protein arginine methyltransferase 7	Homo sapiens	23-28
19012067-8	2008	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of hCGbeta epitope consists of Arg (94,95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Arginine	188-191	chorionic gonadotropin subunit beta 3	Homo sapiens	160-167
32585103-2	2020	The main strategies of PRMT7 in reducing the activation barrier for methyl transfer that are found in this study include (1) formation of reactive (near attack) conformations for the substrate Arg, (2) strengthening the active-site interactions at the transition state, and (3) generation of more effective nucleophiles by changing charge distributions on the target Arg through active-site interactions.	Arginine	367-370	protein arginine methyltransferase 7	Homo sapiens	23-28
32585103-7	2020	The results showed that PRMT7 has a preference of adding a methyl group to the omega-guanidino nitrogen Nn2 atom of the substrate Arg and that the second methylation reactions cannot occur, which are consistent with previous investigations.	Arginine	130-133	protein arginine methyltransferase 7	Homo sapiens	24-29
18679674-2	2008	It was believed that CphA requires L-aspartic acid (Asp), L-arginine (Arg), ATP, Mg2+, and a primer (low-molecular mass cyanophycin) for cyanophycin synthesis and catalyzes the elongation of a low-molecular mass cyanophycin.	Arginine	58-68	tlr2170	Thermosynechococcus elongatus BP-1	21-25
32776922-7	2020	We further show that this arginine export involves Ypq2, a vacuolar protein homologous to the human lysosomal cationic amino acid exporter PQLC2 and whose activity is detected only in nitrogen-starved cells.	Arginine	26-34	solute carrier family 66 member 1	Homo sapiens	139-144
18679674-2	2008	It was believed that CphA requires L-aspartic acid (Asp), L-arginine (Arg), ATP, Mg2+, and a primer (low-molecular mass cyanophycin) for cyanophycin synthesis and catalyzes the elongation of a low-molecular mass cyanophycin.	Arginine	70-73	tlr2170	Thermosynechococcus elongatus BP-1	21-25
18679674-5	2008	The Tlr2170 protein showed strict substrate specificity toward Asp and Arg.	Arginine	71-74	tlr2170	Thermosynechococcus elongatus BP-1	4-11
32692156-3	2020	UBR1 and UBR2 are sequelogous, functionally overlapping, and dominate the targeting of Arg/N-degron substrates in examined cell lines.	Arginine	87-90	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	0-4
18836295-7	2008	Recently, some studies indicated that coupling special ligand like NGR (N: asparagine, G: glycine, R: arginine) peptide targeting to tumor blood vessels with delivery system can enhance the efficacy of gene transfection.	Arginine	102-110	reticulon 4 receptor	Homo sapiens	67-70
32692156-8	2020	We also show, through chase-degradation assays with [UBR1-/- UBR2-/-] and wild-type human cells, that the Arg/N-degron pathway mediates a large fraction of ATF3 degradation.	Arginine	106-109	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	53-57
32643209-9	2020	Our findings suggested that zebrafish prmt3 negatively regulated the antiviral responses, implicating the vital role of prmt3-or even arginine methylation-in antiviral innate immunity.	Arginine	134-142	protein arginine methyltransferase 3	Danio rerio	38-43
32618109-8	2020	A ARG-based model was constructed based on the four ARGs and two clinicopathological risk factors (age and TNM stage), dividing patients into high-risk and low-risk groups.	Arginine	2-5	teneurin transmembrane protein 1	Homo sapiens	107-110
19021703-10	2008	Conversely, ARG supplementation prevents these metabolic abnormalities and restored MMP/TIMP-1 balance.	Arginine	12-15	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	88-94
18658131-2	2008	The interactions between the two proteins have been attributed primarily to binding of the somatomedin B (SMB) domain, which comprises the N-terminal 44 residues of vitronectin, to the flexible joint region of PAI-1, including residues Arg-103, Met-112, and Gln-125 of PAI-1.	Arginine	236-239	vitronectin	Homo sapiens	91-104
18658131-2	2008	The interactions between the two proteins have been attributed primarily to binding of the somatomedin B (SMB) domain, which comprises the N-terminal 44 residues of vitronectin, to the flexible joint region of PAI-1, including residues Arg-103, Met-112, and Gln-125 of PAI-1.	Arginine	236-239	vitronectin	Homo sapiens	106-109
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	8-16	serine and arginine rich splicing factor 1	Homo sapiens	38-45
32664451-6	2020	In Cndp1-KO mice at week 11, renal asparagine, serine and glutamine levels and at week 55, renal arginine concentration were reduced.	Arginine	97-105	carnosine dipeptidase 1 (metallopeptidase M20 family)	Mus musculus	3-8
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	236-244	serine and arginine rich splicing factor 1	Homo sapiens	38-45
18687337-1	2008	The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) and a C-terminal arginine-serine repeat region (RS domain, a domain rich in arginine-serine repeats).	Arginine	236-244	serine and arginine rich splicing factor 1	Homo sapiens	38-45
32072766-1	2020	AIM: Arginase 2 (ARG2) is a mitochondrial enzyme that catalyzes hydrolysis of L-arginine into urea and L-ornithine.	Arginine	78-88	arginase type II	Mus musculus	5-15
18798205-0	2008	Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.	Arginine	105-113	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	32-64
18676353-4	2008	Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated.	Arginine	42-50	protein arginine methyltransferase 1	Homo sapiens	152-157
18676353-4	2008	Furthermore, when the endogenous level of arginine-dimethylated proteins was determined, asymmetric modification (the product of type I PRMTs including PRMT1, PRMT4 and PRMT6) was markedly down-regulated.	Arginine	42-50	coactivator associated arginine methyltransferase 1	Homo sapiens	159-164
32072766-1	2020	AIM: Arginase 2 (ARG2) is a mitochondrial enzyme that catalyzes hydrolysis of L-arginine into urea and L-ornithine.	Arginine	78-88	arginase type II	Mus musculus	17-21
32450431-7	2020	Further echoing the situation in lymphocytes, LPA unbridles the protease activity of MALT1, which cleaves HOIL1 at the Arginine 165.	Arginine	119-127	MALT1 paracaspase	Mus musculus	85-90
18628402-7	2008	It is noteworthy that swapping these charges by introduction of Glu in II:20 and Arg in III:03 resulted in a 2.7-fold increase compared with wt EBI2, thereby rescuing the two signaling-deficient single mutations, which exhibited a 3.8- to 4.5-fold decrease in constitutive activity.	Arginine	81-84	G protein-coupled receptor 183	Homo sapiens	144-148
32450431-7	2020	Further echoing the situation in lymphocytes, LPA unbridles the protease activity of MALT1, which cleaves HOIL1 at the Arginine 165.	Arginine	119-127	RanBP-type and C3HC4-type zinc finger containing 1	Mus musculus	106-111
18800761-0	2008	Melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH2 modified at the para position of the benzyl side chain (DPhe): importance for mouse melanocortin-3 receptor agonist versus antagonist activity.	Arginine	38-41	melanocortin 3 receptor	Mus musculus	134-157
32274508-9	2020	In particular, most of the 51 mcr-3-positive isolates belonged to ST34 and harboured diverse antibiotic resistance genes (ARGs), including mcr-3-blaCTX-M-55-qnrS1, and possessed similar ARG profiles.	Arginine	122-125	quinolone resistance gene	Salmonella enterica subsp. enterica serovar Typhimurium	157-162
18695005-7	2008	We provide evidence for depletion of arginine in the inflamed hepatic microenvironment as a potential mechanism for these defects in global CD8 T cell signaling and function.	Arginine	37-45	CD8a molecule	Homo sapiens	140-143
18502762-3	2008	Here, we show that Dkk1 residues Arg(197), Ser(198), and Lys(232) are specifically involved in its binding to Kremen rather than to LRP6.	Arginine	33-36	LDL receptor related protein 6	Homo sapiens	132-136
18541539-7	2008	The amino acid exchange does not impact on the overall fold and nucleotide binding, as seen in the monomeric x-ray crystallographic structure of the Arabidopsis Toc33 arginine-alanine replacement variant at 2.0A.	Arginine	167-175	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	161-166
18524858-3	2008	Since l-arginine transport by CAT-1 (the specific arginine transporter for eNOS) is inhibited in uremia, we aimed to explore the effect of rosiglitazone on arginine transport in CRF.	Arginine	6-16	nitric oxide synthase 3	Rattus norvegicus	75-79
18524858-3	2008	Since l-arginine transport by CAT-1 (the specific arginine transporter for eNOS) is inhibited in uremia, we aimed to explore the effect of rosiglitazone on arginine transport in CRF.	Arginine	8-16	nitric oxide synthase 3	Rattus norvegicus	75-79
18524858-12	2008	In conclusion, rosiglitazone prevents the decrease in arginine uptake in CRF through both depletion and inactivation of PKCalpha.	Arginine	54-62	protein kinase C, alpha	Rattus norvegicus	120-128
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	79-82	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	31-37
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	79-82	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	178-184
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	83-86	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	31-37
17931634-9	2008	An interaction between p53 and PTPN22 was observed: a protective action by the Arg/Arg genotype against endometriosis seems to be present only in carriers of the ( *)T allele of PTPN22.	Arginine	83-86	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	178-184
18590276-1	2008	Prothrombinase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	98-101	coagulation factor X	Homo sapiens	0-14
18580570-3	2008	The technetium-99m-labeled Arg-Gly-Asp peptide, with high affinity to integrin alphavbeta3, was prepared for biodistribution and gamma-imaging.	Arginine	27-30	integrin subunit alpha V	Homo sapiens	70-90
18627314-4	2008	Enzymatically active recombinant azurocidin caused cleavage of the C-terminal fusion tag with the primary cleavage site after lysine at Lys-Leu and after alanine at Ala-Ala, and the secondary cleavage site after arginine at Arg-Gln, as well as with low efficiency caused cleavage of insulin chain B after leucine at Leu-Tyr and Leu-Cys, and after alanine at Ala-Leu.	Arginine	212-220	azurocidin 1	Homo sapiens	33-43
18627314-4	2008	Enzymatically active recombinant azurocidin caused cleavage of the C-terminal fusion tag with the primary cleavage site after lysine at Lys-Leu and after alanine at Ala-Ala, and the secondary cleavage site after arginine at Arg-Gln, as well as with low efficiency caused cleavage of insulin chain B after leucine at Leu-Tyr and Leu-Cys, and after alanine at Ala-Leu.	Arginine	224-227	azurocidin 1	Homo sapiens	33-43
18627314-6	2008	The first isoleucine present in mature azurocidin can be replaced by similar amino acids, such as leucine or valine, but its substitution by histidine or arginine decreases proteolytic activity.	Arginine	154-162	azurocidin 1	Homo sapiens	39-49
19035188-7	2008	CONCLUSION: The GPX1 198 Pro/Pro and TXNRD2 370Arg/Arg genotypes might be associated with the genetic susceptibility of gastric cancer.	Arginine	47-50	glutathione peroxidase 1	Homo sapiens	16-20
18523251-6	2008	The lysine-free HIV-1 Nef mutant (Delta10K) generated by replacing all 10 lysines with arginines was not ubiquitinated and the major ubiquitin-His attachment sites in HIV-1 Nef were determined to be lysine 144 (di-ubiquitinated) and lysine 204 (mono-ubiquitinated).	Arginine	87-96	Nef	Human immunodeficiency virus 1	22-25
18331837-2	2008	In 2 severely affected patients, IDS missense mutations, c.1016T&gt;C (novel) and c.1016T&gt;G (known) were identified predicting the substitution of an ambivalent cyclic proline and a hydrophilic arginine respectively for the hydrophobic leucine at residue 339.	Arginine	197-205	iduronate 2-sulfatase	Homo sapiens	33-36
17983645-2	2008	The plasma membrane receptor is located on integrin alphaVbeta3 at the Arg-Gly-Asp recognition site important to the binding by the integrin of extracellular matrix proteins.	Arginine	71-74	integrin subunit alpha V	Homo sapiens	43-63
18424593-7	2008	The arginine treatment enhanced the formation of the active eIF4E x eIF4G complex but reduced the amount of the inactive 4E-BP1 x eIF4E complex in muscle.	Arginine	4-12	eukaryotic translation initiation factor 4E	Sus scrofa	60-65
18424593-7	2008	The arginine treatment enhanced the formation of the active eIF4E x eIF4G complex but reduced the amount of the inactive 4E-BP1 x eIF4E complex in muscle.	Arginine	4-12	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	68-73
18424593-7	2008	The arginine treatment enhanced the formation of the active eIF4E x eIF4G complex but reduced the amount of the inactive 4E-BP1 x eIF4E complex in muscle.	Arginine	4-12	eukaryotic translation initiation factor 4E	Sus scrofa	130-135
18347060-7	2008	The depletion of PRMT5 in p19 cells stimulates E-cadherin expression, and the SNAIL, AJUBA, and PRMT5 ternary complex can be found at the proximal promoter region of the E-cadherin gene, concomitant with increased arginine methylation of histones at the locus.	Arginine	214-222	ajuba LIM protein	Homo sapiens	85-90
18399855-9	2008	CONCLUSIONS: These findings indicate that the homozygous Arg/Arg genotype at amino acid 16 of the beta(2)-AR could affect bronchodilator response to tiotropium in patients with COPD with significant effects on health-related quality of life.	Arginine	57-60	adrenoceptor beta 2	Homo sapiens	98-108
18399855-9	2008	CONCLUSIONS: These findings indicate that the homozygous Arg/Arg genotype at amino acid 16 of the beta(2)-AR could affect bronchodilator response to tiotropium in patients with COPD with significant effects on health-related quality of life.	Arginine	61-64	adrenoceptor beta 2	Homo sapiens	98-108
18331527-3	2008	DQB1 exon 4 sequencing confirmed the exchange of codon 189-arginine (CGG), which is replaced by tryptophan (TGG) in the new allele DQB1*0634.	Arginine	59-67	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	0-4
18331527-3	2008	DQB1 exon 4 sequencing confirmed the exchange of codon 189-arginine (CGG), which is replaced by tryptophan (TGG) in the new allele DQB1*0634.	Arginine	59-67	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	131-135
20641544-25	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
18160133-0	2008	A new detection method for arginine-specific ADP-ribosylation of protein -- a combinational use of anti-ADP-ribosylarginine antibody and ADP-ribosylarginine hydrolase.	Arginine	27-35	ADP-ribosylarginine hydrolase	Rattus norvegicus	137-166
18319063-1	2008	N-acetyl-L-glutamate synthase (NAGS), the first enzyme of bacterial/plant arginine biosynthesis and an essential activator of the urea cycle in animals, is, respectively, arginine-inhibited and activated.	Arginine	74-82	N-acetylglutamate synthase	Homo sapiens	0-29
18319063-1	2008	N-acetyl-L-glutamate synthase (NAGS), the first enzyme of bacterial/plant arginine biosynthesis and an essential activator of the urea cycle in animals, is, respectively, arginine-inhibited and activated.	Arginine	74-82	N-acetylglutamate synthase	Homo sapiens	31-35
18319063-1	2008	N-acetyl-L-glutamate synthase (NAGS), the first enzyme of bacterial/plant arginine biosynthesis and an essential activator of the urea cycle in animals, is, respectively, arginine-inhibited and activated.	Arginine	171-179	N-acetylglutamate synthase	Homo sapiens	0-29
18319063-1	2008	N-acetyl-L-glutamate synthase (NAGS), the first enzyme of bacterial/plant arginine biosynthesis and an essential activator of the urea cycle in animals, is, respectively, arginine-inhibited and activated.	Arginine	171-179	N-acetylglutamate synthase	Homo sapiens	31-35
18319063-2	2008	Site-directed mutagenesis of recombinant Pseudomonas aeruginosa NAGS (PaNAGS) delineates the arginine site in the PaNAGS acetylglutamate kinase-like domain, and, by extension, in human NAGS.	Arginine	93-101	N-acetylglutamate synthase	Homo sapiens	64-68
18319063-2	2008	Site-directed mutagenesis of recombinant Pseudomonas aeruginosa NAGS (PaNAGS) delineates the arginine site in the PaNAGS acetylglutamate kinase-like domain, and, by extension, in human NAGS.	Arginine	93-101	N-acetylglutamate synthase	Homo sapiens	72-76
18325336-1	2008	In higher plants, the PII protein is a nuclear-encoded plastid protein that regulates the activity of a key enzyme of arginine biosynthesis.	Arginine	118-126	nitrogen regulatory P-II-like protein	Arabidopsis thaliana	22-25
18258176-0	2008	Arginine and glycine stimulate creatine synthesis in creatine transporter 1-deficient lymphoblasts.	Arginine	0-8	solute carrier family 6 member 8	Homo sapiens	53-75
18324973-4	2008	We found that the beta(2)AR arg(16)--&gt;gly substitution and two non-coding ADCY6 polymorphisms were associated with elevated adhesion.	Arginine	28-31	adrenoceptor beta 2	Homo sapiens	18-27
18380667-3	2008	The aim of the present work was thus to analyse how the genes of arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), allowing creatine synthesis, as well as of the creatine transporter SLC6A8, allowing creatine uptake into cells, are regulated in rat brain cells under NH4+ exposure.	Arginine	65-73	glycine amidinotransferase	Homo sapiens	102-106
18364396-6	2008	Consistent with a model in which TAP directly binds mRNA handed over from adaptors during export, we show that TAP binds mRNA in vivo by an arginine-rich motif in its N-terminal domain.	Arginine	140-148	nuclear RNA export factor 1	Homo sapiens	111-114
18393249-5	2008	There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively.	Arginine	107-110	X-ray repair cross complementing 1	Homo sapiens	98-103
18393249-5	2008	There was a 3.37-fold or 2.54-fold increased risk of laryngeal carcinoma for individuals carrying XRCC1-399Arg/Gln+ Gln/Gln or hOGG1-326Ser/Cys+ Cys/Cys genotypes, compared with subjects carrying XRCC1-Arg/Arg or hOGG1-Ser/Ser genotype, respectively.	Arginine	202-205	X-ray repair cross complementing 1	Homo sapiens	98-103
20641496-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
18156200-9	2008	Intraperitoneal injection of alpha-tocopherol, a PKC-alpha inhibitor, prevented the decrease in arginine transport and attenuated protein nitration.	Arginine	96-104	protein kinase C, alpha	Rattus norvegicus	49-58
18156200-10	2008	In conclusion, aortic arginine uptake is reduced during pregnancy, through posttranslational modulation of CAT-1 protein, presumably via upregulation of PKC-alpha.	Arginine	22-30	protein kinase C, alpha	Rattus norvegicus	153-162
18316480-3	2008	We show that RUNX1 is arginine-methylated in vivo by the arginine methyltransferase PRMT1, and that PRMT1 serves as a transcriptional coactivator for RUNX1 function.	Arginine	22-30	protein arginine methyltransferase 1	Homo sapiens	84-89
18316480-4	2008	Using mass spectrometry, and a methyl-arginine-specific antibody, we identified two arginine residues (R206 and R210) within the region of RUNX1 that interact with the corepressor SIN3A and are methylated by PRMT1.	Arginine	84-92	protein arginine methyltransferase 1	Homo sapiens	208-213
18316480-5	2008	PRMT1- dependent methylation of RUNX1 at these arginine residues abrogates its association with SIN3A, whereas shRNA against PRMT1 (or use of a methyltransferase inhibitor) enhances this association.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	0-5
18316480-6	2008	We find arginine-methylated RUNX1 on the promoters of two bona fide RUNX1 target genes, CD41 and PU.1 and show that shRNA against PRMT1 or RUNX1 down-regulates their expression.	Arginine	8-16	integrin subunit alpha 2b	Homo sapiens	88-92
18316480-6	2008	We find arginine-methylated RUNX1 on the promoters of two bona fide RUNX1 target genes, CD41 and PU.1 and show that shRNA against PRMT1 or RUNX1 down-regulates their expression.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	130-135
18172665-2	2008	Moreover, we tested the hypothesis that L -arginine and L -ornithine influence the expression and synthesis of hCAT1 and hCAT2 in cell culture experiments by means of real-time-PCR and Western blot.	Arginine	40-51	solute carrier family 7 member 1	Homo sapiens	111-116
18172665-4	2008	Cell culture experiments showed that supraphysiological concentrations of 15 mM L -arginine (72 h) lead to a significant increase of the hCAT1-mRNA and protein expression, whereas other concentrations had no significant influence.	Arginine	80-91	solute carrier family 7 member 1	Homo sapiens	137-142
18709962-7	2008	Bi-directional sequencing of exon 3 showed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (TTR Arg-83).	Arginine	160-163	transthyretin	Homo sapiens	156-159
18709962-8	2008	TTR Arg-83 may be a new pathologic mutation in vitreous amyloidosis.	Arginine	4-7	transthyretin	Homo sapiens	0-3
18220330-1	2008	The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R).	Arginine	34-37	melanocortin 4 receptor	Rattus norvegicus	200-223
18220330-1	2008	The tetrapeptide sequence His-Phe-Arg-Trp, derived from melanocyte-stimulating hormone (alphaMSH) and its analogs, causes a decrease in food intake and elevates energy utilization upon binding to the melanocortin-4 receptor (MC4R).	Arginine	34-37	melanocortin 4 receptor	Rattus norvegicus	225-229
18083705-6	2008	Recombinant PAD1 and PAD2 are capable of converting all 4 arginines in recombinant S100A3, whereas PAD3 specifically converts only Arg-51 into citrulline.	Arginine	58-67	peptidyl arginine deiminase 2	Homo sapiens	21-25
18083705-6	2008	Recombinant PAD1 and PAD2 are capable of converting all 4 arginines in recombinant S100A3, whereas PAD3 specifically converts only Arg-51 into citrulline.	Arginine	131-134	peptidyl arginine deiminase 3	Homo sapiens	99-103
18094146-7	2008	When H26 was replaced with arginine, the pH(i) sensitivity profile was similar to that of the H26A mutant but with the pK(a) shifted to a more acidic value, giving rise to whole cell current amplitude at resting pH(i) that was comparable to that of wild-type Kir7.1.	Arginine	27-35	potassium inwardly rectifying channel subfamily J member 13	Homo sapiens	259-265
18156192-1	2008	Nitric oxide (NO), generated from L-arginine by endothelial nitric oxide synthase (eNOS), is a key endothelial-derived factor whose bioavailability is essential to the normal function of the endothelium.	Arginine	34-44	nitric oxide synthase 3	Rattus norvegicus	48-81
18156192-1	2008	Nitric oxide (NO), generated from L-arginine by endothelial nitric oxide synthase (eNOS), is a key endothelial-derived factor whose bioavailability is essential to the normal function of the endothelium.	Arginine	34-44	nitric oxide synthase 3	Rattus norvegicus	83-87
20641499-1	2004	(99m)Tc-(Arg(11))CCMSH is an alpha-melanocyte-stimulating hormone (MSH) peptide labeled with (99m)Tc, a gamma emitter with a physical t1/2 of 6 h. Malignant melanoma is the sixth most common cancer in the United States (1).	Arginine	9-12	msh homeobox 1	Mus musculus	19-22
32563156-3	2020	Mechanistic assays in breast cancer cells indicate that PRMT1 methylates PR at the arginine 637 and reduces the stability of the receptor, thereby accelerating its recycling and finally its transcriptional activity.	Arginine	83-91	protein arginine methyltransferase 1	Homo sapiens	56-61
17845003-2	2008	Both integrins and APN recognize a broad range of peptides containing RGD (Arg-Gly-Asp) and NGR (Asn-Gly-Arg) motifs, respectively.	Arginine	105-108	reticulon 4 receptor	Homo sapiens	92-95
18172323-5	2008	Upon estrogen stimulation, the E2F1 promoter is subject to CARM1-dependent dimethylation on histone H3 arginine 17 (H3R17me2) in a process that parallels the recruitment of ER alpha.	Arginine	103-111	coactivator associated arginine methyltransferase 1	Homo sapiens	59-64
32637492-3	2020	We employed Synthetic Dosage Lethality (SDL) screening in Saccharomyces cerevisiae, for the identification of putative regulators of arginine methylation mediated by Hmt1 (HnRNP methyltransferase 1), ortholog of human PRMT1.	Arginine	133-141	protein arginine methyltransferase 1	Homo sapiens	218-223
32543462-10	2020	However, heterozygote genotypes (Gln-Arg and Ile-Val) in XRCC1 and GSTP1 genes, respectively, were associated with LINE-1 hypermethylation among UE compared with other corresponding genotypes.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	57-62
18680141-1	2008	Accumulating evidence suggests that agmatine, a metabolite of L-arginine by arginine decarboxylase, is a novel neurotransmitter, and exogenous agmatine can modulate behavior functions including learning and memory.	Arginine	62-72	antizyme inhibitor 2	Rattus norvegicus	76-98
32365184-9	2020	These results highlight a novel role for PRMT7-mediated arginine methylation of RBP substrates, suggesting a regulatory pathway controlling gene expression and virulence in Leishmania.	Arginine	56-64	protein arginine methyltransferase 7	Homo sapiens	41-46
18214807-6	2008	Among exposed workers, subjects with the combination of MPO G/G and XRCC1 Arg/Gln or Gln/Gln showed a significantly higher CA frequency compared to those with the combination of MPO G/A or A/A and XRCC1 Arg/Arg genotypes.	Arginine	74-77	X-ray repair cross complementing 1	Homo sapiens	68-73
17971348-6	2008	Stratified analysis by occupational exposure showed a significant MN increase with smoking in occupationally exposed carriers of the Arg/Gln XRCC1(399)genotype (P &lt; 0.001).	Arginine	133-136	X-ray repair cross complementing 1	Homo sapiens	141-146
32429593-11	2020	Together, this study unveils a novel regulatory mechanism of p38alpha activation via protein arginine methylation on R49/R149 by PRMT1, which impacts partner interaction and thus promotes erythroid differentiation.	Arginine	93-101	protein arginine methyltransferase 1	Homo sapiens	129-134
32058567-2	2020	Consequently, most existing ARG databases contain only a small number of ARGs (~5k genes) and updates to these databases tend to be infrequent, commonly requiring years for completion and often containing inconsistencies.	Arginine	28-31	serpin family A member 2 (gene/pseudogene)	Homo sapiens	73-77
17999653-2	2008	DQB1*0632 differs from DQB1*0603 by one nucleotide change in exon 2 resulting in the amino acid exchange Gly --&gt; Arg.	Arginine	116-119	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	0-4
17999653-2	2008	DQB1*0632 differs from DQB1*0603 by one nucleotide change in exon 2 resulting in the amino acid exchange Gly --&gt; Arg.	Arginine	116-119	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	23-27
32114003-0	2020	The antidepressant effects of l-arginine on chronic mild stress-induced depression by augmenting the expression of brain-derived neurotrophic factor in rats.	Arginine	30-40	brain-derived neurotrophic factor	Rattus norvegicus	115-148
17971302-1	2007	Protein N-arginine methyltransferase (PRMT)1 catalyzes arginine methylation in a variety of substrates, although the potential role of PRMT1 in insulin action has not been defined.	Arginine	10-18	protein arginine methyltransferase 1	Homo sapiens	135-140
17971302-4	2007	Several proteins in the membrane fraction were arginine-methylated after insulin treatment, which were inhibited by pretreatment with an inhibitor of methyltransferase, 5"-deoxy-5"-(methylthio)adenosine (MTA), or a small interfering RNA against PRMT1 (PRMT1-siRNA).	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	245-250
17971302-4	2007	Several proteins in the membrane fraction were arginine-methylated after insulin treatment, which were inhibited by pretreatment with an inhibitor of methyltransferase, 5"-deoxy-5"-(methylthio)adenosine (MTA), or a small interfering RNA against PRMT1 (PRMT1-siRNA).	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	252-257
17938381-5	2007	In female offspring, gene expression of argininosuccinate synthase (involved in renal arginine synthesis) and renal cationic amino acid Y-transporter (involved in arginine reabsorption) were both decreased in 2-day and 2-week SHRs compared with normotensive WKY, although no abnormalities in amino acid pools were observed.	Arginine	86-94	argininosuccinate synthase 1	Rattus norvegicus	40-66
32114003-9	2020	However, supplementation with l-arginine significantly increased BDNF mRNA expression (>50 %) in both groups.	Arginine	30-40	brain-derived neurotrophic factor	Rattus norvegicus	65-69
17938381-5	2007	In female offspring, gene expression of argininosuccinate synthase (involved in renal arginine synthesis) and renal cationic amino acid Y-transporter (involved in arginine reabsorption) were both decreased in 2-day and 2-week SHRs compared with normotensive WKY, although no abnormalities in amino acid pools were observed.	Arginine	163-171	argininosuccinate synthase 1	Rattus norvegicus	40-66
32114003-10	2020	Similarly, increased BDNF protein expression after l-arginine treatment was confirmed using Western blot and immunohistochemical analyses.	Arginine	51-61	brain-derived neurotrophic factor	Rattus norvegicus	21-25
32357153-6	2020	Thus, we speculate that the Arg-type DFR is a new DFR functional type.	Arginine	28-31	dihydroflavonol 4-reductase	Arabidopsis thaliana	37-40
17686851-3	2007	Here we show that 100K is methylated on arginine residues at its C terminus during infection and that this region is necessary for binding PRMT1 methylase.	Arginine	40-48	protein arginine methyltransferase 1	Homo sapiens	139-144
32357153-6	2020	Thus, we speculate that the Arg-type DFR is a new DFR functional type.	Arginine	28-31	dihydroflavonol 4-reductase	Arabidopsis thaliana	50-53
32357153-7	2020	To further verify the substrate preferences of the Arg-type DFR, an amino acid substitution assay was conducted.	Arginine	51-54	dihydroflavonol 4-reductase	Arabidopsis thaliana	60-63
17899335-2	2007	The BRCT1 domain of XRCC1 is responsible for interacting with several of the key components of the BER machinery, and it is also the site of a common genetic polymorphism in XRCC1 at amino acid residue 399 (Arg --&gt; Gln).	Arginine	207-210	X-ray repair cross complementing 1	Homo sapiens	20-25
17899335-2	2007	The BRCT1 domain of XRCC1 is responsible for interacting with several of the key components of the BER machinery, and it is also the site of a common genetic polymorphism in XRCC1 at amino acid residue 399 (Arg --&gt; Gln).	Arginine	207-210	X-ray repair cross complementing 1	Homo sapiens	174-179
32321555-0	2020	Arginine is neuroprotective through suppressing HIF-1alpha/LDHA-mediated inflammatory response after cerebral ischemia/reperfusion injury.	Arginine	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	48-58
32321555-5	2020	We further provide evidence that the levels of HIF-1alpha and LDHA are increased after rat I/R injury and that arginine treatment prevents the elevation of HIF-1alpha and LDHA after I/R injury.	Arginine	111-119	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	47-57
32321555-5	2020	We further provide evidence that the levels of HIF-1alpha and LDHA are increased after rat I/R injury and that arginine treatment prevents the elevation of HIF-1alpha and LDHA after I/R injury.	Arginine	111-119	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	156-166
17763933-6	2007	EB1 and P3HR-1 had non-silent mutations in the sequences leading to the arginine/serine and threonine/proline interchanges at residues 4 and 166, respectively.	Arginine	72-80	microtubule associated protein RP/EB family member 1	Homo sapiens	0-3
32321555-6	2020	Arginine inhibits inflammatory response through suppression of HIF-1alpha and LDHA in the rat ischemic brain tissue and in the cultured microglia following OGD insult, and protects against ischemic neuron death after rat I/R injury by attenuating HIF-1alpha/LDHA-mediated inflammatory response.	Arginine	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	63-73
32321555-6	2020	Arginine inhibits inflammatory response through suppression of HIF-1alpha and LDHA in the rat ischemic brain tissue and in the cultured microglia following OGD insult, and protects against ischemic neuron death after rat I/R injury by attenuating HIF-1alpha/LDHA-mediated inflammatory response.	Arginine	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	247-257
17924455-8	2007	By metabolome analysis of intracellular compounds, the amount of histidine and arginine is increased, and the amount of threonine, lysine and nicotinic acid is decreased in the Ami1p-overproducing strain as compared with the control, suggesting that Ami1p may hydrolyse some amides related to amino acid and niacin metabolism in the cell.	Arginine	79-87	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	177-182
32321555-7	2020	Together, these results indicate a possibility that arginine-induced neuroprotective effect may be through the suppression of HIF-1alpha/LDHA-mediated inflammatory response in microglia after cerebral ischemia injury.	Arginine	52-60	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	126-136
32290120-0	2020	Intravenous Arginine Administration Benefits CD4+ T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis.	Arginine	12-20	CD4 antigen	Mus musculus	45-48
32290120-1	2020	This study investigated the effects of a single dose of arginine (Arg) administration at the beginning of sepsis on CD4+ T-cell regulation and liver inflammation in C57BL/6J mice.	Arginine	56-64	CD4 antigen	Mus musculus	116-119
32290120-1	2020	This study investigated the effects of a single dose of arginine (Arg) administration at the beginning of sepsis on CD4+ T-cell regulation and liver inflammation in C57BL/6J mice.	Arginine	66-69	CD4 antigen	Mus musculus	116-119
17985933-9	2007	Residues Lys 7 and Arg 5 play important roles in the interaction with MEK5 PB1.	Arginine	19-22	submaxillary gland androgen regulated protein 3A	Homo sapiens	75-78
32290120-9	2020	Compared to the SS group, Arg administration resulted in maintained circulating and para-aortic lymph node CD4+ T cells, an increased Th1/Th2 ratio, and a reduced Th17/Treg ratio post-CLP.	Arginine	26-29	CD4 antigen	Mus musculus	107-110
32290120-11	2020	These results suggest that a single dose of Arg administered after CLP increased Arg availability, sustained CD4+ T-cell populations, elicited more-balanced Th1/Th2/Th17/Treg polarization in the circulation and the para-aortic lymph nodes, and attenuated liver inflammation in sepsis.	Arginine	44-47	CD4 antigen	Mus musculus	109-112
32309436-9	2020	In addition, we observed that the apoptotic index of cells with H/R stimulation was reduced when NCMs were pretreated with PERK-rAAV9, Nrf2-rAAV9, or HO-1-rAAV9.	Arginine	66-67	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	123-127
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	23-26	coagulation factor X	Homo sapiens	73-82
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	23-26	coagulation factor X	Homo sapiens	84-87
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	23-26	coagulation factor X	Homo sapiens	162-165
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	33-36	coagulation factor X	Homo sapiens	73-82
17878169-2	2007	Limited proteolysis at Arg(709), Arg(1018), and Arg(1545) by thrombin or Factor Xa (FXa) results in the generation of activated FV, which serves as a cofactor of FXa in prothrombin activation.	Arginine	33-36	coagulation factor X	Homo sapiens	73-82
31941782-3	2020	We observed that all sensitive viruses have an Arg residue at the P4 position of the cleavage site between the nonstructural protein P1 (nsP1) and nsP2 regions of the replicase precursor polyprotein (1/2 site), while a different residue is found at this site in viruses resistant to G3BP deletion.	Arginine	47-50	SH2 domain containing 3A	Homo sapiens	137-141
17878166-9	2007	The Arg(26) in SCA3, replacing the Gly(26) in SCA1, is predicted to cause structural changes that result in a significantly reduced volume for the internal hydrophobic cavity in SCA3.	Arginine	4-7	ataxin 3	Homo sapiens	15-19
17878166-9	2007	The Arg(26) in SCA3, replacing the Gly(26) in SCA1, is predicted to cause structural changes that result in a significantly reduced volume for the internal hydrophobic cavity in SCA3.	Arginine	4-7	ataxin 3	Homo sapiens	178-182
31941782-3	2020	We observed that all sensitive viruses have an Arg residue at the P4 position of the cleavage site between the nonstructural protein P1 (nsP1) and nsP2 regions of the replicase precursor polyprotein (1/2 site), while a different residue is found at this site in viruses resistant to G3BP deletion.	Arginine	47-50	G3BP stress granule assembly factor 1	Homo sapiens	283-287
31923495-4	2020	In contrast to Escherichia coli aminopeptidase N, a previously characterized M1 peptidase, M1dr exhibits reduced activity towards peptides with N-terminal Arg or Ala residue.	Arginine	155-158	aminopeptidase N	Escherichia coli	32-48
18006764-7	2007	Of these three XRCC1 polymorphisms, the codon 399 Arg/Gln + Gln/Gn genotypes were significantly associated with higher risk of PSA recurrence after radical prostatectomy compared with the Arg/Arg genotype (34.0% versus 15.1%, P = 0.013) and poorer PSA-free survival (log-rank test, P = 0.0056).	Arginine	50-53	X-ray repair cross complementing 1	Homo sapiens	15-20
17726029-1	2007	Previous work showed that prothrombin derivatives cleavable only at Arg-320 (rMZ) or Arg-271 (rP2) are partial, rather than competitive, inhibitors of prothrombin activation by prothrombinase.	Arginine	68-71	coagulation factor X	Homo sapiens	177-191
31932825-3	2020	During Env immunogen production, endogenous furin works to cleave a hexa-arginine motif connecting the gp120 and gp41 subunits, which is needed to ensure proper protein folding and a native-like conformation of Env.	Arginine	73-81	endogenous retrovirus group K member 20	Homo sapiens	7-10
17726029-1	2007	Previous work showed that prothrombin derivatives cleavable only at Arg-320 (rMZ) or Arg-271 (rP2) are partial, rather than competitive, inhibitors of prothrombin activation by prothrombinase.	Arginine	85-88	coagulation factor X	Homo sapiens	177-191
31932825-3	2020	During Env immunogen production, endogenous furin works to cleave a hexa-arginine motif connecting the gp120 and gp41 subunits, which is needed to ensure proper protein folding and a native-like conformation of Env.	Arginine	73-81	endogenous retrovirus group K member 20	Homo sapiens	211-214
32206101-10	2020	A large number of CARM1 substrates were found to be exclusively hypermethylated by CARM1 on a cluster of arginine residues.	Arginine	105-113	coactivator associated arginine methyltransferase 1	Homo sapiens	18-23
17960137-5	2007	This occurs by antagonizing multiple Arg clusters in the SMO cytoplasmic tail.	Arginine	37-40	smoothened	Drosophila melanogaster	57-60
17960137-6	2007	The Arg clusters inhibit SMO by blocking its cell surface expression and keeping it in an inactive conformation that is maintained by intramolecular electrostatic interactions.	Arginine	4-7	smoothened	Drosophila melanogaster	25-28
17960137-8	2007	Increasing the number of mutations in the Arg clusters progressively activates SMO.	Arginine	42-45	smoothened	Drosophila melanogaster	79-82
17960137-9	2007	Hence, by employing multiple Arg clusters as inhibitory elements counteracted by differential phosphorylation, SMO acts as a rheostat to translate graded HH signals into distinct responses.	Arginine	29-32	smoothened	Drosophila melanogaster	111-114
32206101-10	2020	A large number of CARM1 substrates were found to be exclusively hypermethylated by CARM1 on a cluster of arginine residues.	Arginine	105-113	coactivator associated arginine methyltransferase 1	Homo sapiens	83-88
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Arginine	132-135	X-ray repair cross complementing 1	Homo sapiens	122-127
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Arginine	136-139	X-ray repair cross complementing 1	Homo sapiens	122-127
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Arginine	136-139	X-ray repair cross complementing 1	Homo sapiens	122-127
17912469-7	2007	Compared with the Lys/Lys genotype, the XPD 751 Lys/ increased 5.100- or 3.064-fold, respectively, when combined with the XRCC1 194 Arg/Arg or 399 Arg/Arg genotype.	Arginine	136-139	X-ray repair cross complementing 1	Homo sapiens	122-127
31868900-2	2020	Amino acid starvation, particularly of tryptophan and arginine, affects immune tolerance by suppressing differentiation and proliferation of T-cells via activation of GCN2 kinase.	Arginine	54-62	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	167-171
17724083-8	2007	Finally, we show that two residues in this H2A subdomain, serine-17 and arginine-18, are specifically required for the transcriptional repression of the BNA2 reporter gene.	Arginine	72-80	dioxygenase BNA2	Saccharomyces cerevisiae S288C	153-157
17593927-7	2007	The median survival times for patients with Arg/Arg or Arg/Gln genotypes of XRCC1 gene were significantly longer than others (P=0.03).	Arginine	44-47	X-ray repair cross complementing 1	Homo sapiens	76-81
17593927-7	2007	The median survival times for patients with Arg/Arg or Arg/Gln genotypes of XRCC1 gene were significantly longer than others (P=0.03).	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	76-81
17593927-7	2007	The median survival times for patients with Arg/Arg or Arg/Gln genotypes of XRCC1 gene were significantly longer than others (P=0.03).	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	76-81
17891136-2	2007	Although the methylation of arginine 3 of histone 4 (H4R3) by protein arginine methyltransferase 1 (PRMT1) is a critical modification for active chromatin and prevention of heterochromatin spread, there has been no direct evidence of any role of PRMTs in cancer.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	100-105
17937921-4	2007	By analyzing residues surrounding the ligand side chain, partner ligands were identified for various FFRPs from Pyrococcus, e.g., lysine facilitates homo-octamerization of FL11, and arginine facilitates hetero-octamerization of FL11 and DM1.	Arginine	182-190	DM1 protein kinase	Homo sapiens	237-240
17823247-2	2007	The human SR (serine-arginine) protein ASF/SF2 relies on the processive phosphorylation of the serine residues of eight consecutive arginine-serine (RS) dipeptide repeats at the C terminus by SRPK1 before it can be transported into the nucleus.	Arginine	21-29	serine and arginine rich splicing factor 1	Homo sapiens	39-46
17823247-2	2007	The human SR (serine-arginine) protein ASF/SF2 relies on the processive phosphorylation of the serine residues of eight consecutive arginine-serine (RS) dipeptide repeats at the C terminus by SRPK1 before it can be transported into the nucleus.	Arginine	132-140	serine and arginine rich splicing factor 1	Homo sapiens	39-46
31114027-0	2020	UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.	Arginine	7-15	protein arginine methyltransferase 1	Homo sapiens	31-36
32880207-1	2020	Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine.	Arginine	90-100	arginase 2	Homo sapiens	0-10
32880207-1	2020	Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine.	Arginine	90-100	arginase 2	Homo sapiens	12-16
32880207-3	2020	Increased ARG2 expression leads to a concomitant depletion of local L-arginine levels, which in turn leads to suppression of anti-tumor T-cell-mediated immune responses.	Arginine	68-78	arginase 2	Homo sapiens	10-14
31787756-10	2019	Taken together, our data suggest that ATF4 methylation on arginine 239 by PRMT1 is a novel regulatory mechanism for protection of cardiomyocytes from ER stress-induced cell death.	Arginine	58-66	activating transcription factor 4	Homo sapiens	38-42
31787756-10	2019	Taken together, our data suggest that ATF4 methylation on arginine 239 by PRMT1 is a novel regulatory mechanism for protection of cardiomyocytes from ER stress-induced cell death.	Arginine	58-66	protein arginine methyltransferase 1	Homo sapiens	74-79
31772215-0	2019	Myotonia in a patient with a mutation in an S4 arginine residue associated with hypokalaemic periodic paralysis and a concomitant synonymous CLCN1 mutation.	Arginine	47-55	chloride voltage-gated channel 1	Homo sapiens	141-146
31492534-4	2019	The PDZ binding motif (PBM) and an Arg-rich motif upstream of PBM conserved in TARPs bind to multiple sites on PSD-95, thus resulting in a highly specific and multivalent stargazin/PSD-95 complex.	Arginine	35-38	discs large MAGUK scaffold protein 4	Mus musculus	111-117
20641472-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
31492534-4	2019	The PDZ binding motif (PBM) and an Arg-rich motif upstream of PBM conserved in TARPs bind to multiple sites on PSD-95, thus resulting in a highly specific and multivalent stargazin/PSD-95 complex.	Arginine	35-38	discs large MAGUK scaffold protein 4	Mus musculus	181-187
31454707-6	2019	Destruction of the catalytic cysteine residue in MC4 or the conserved arginine residue preceding the Pep1 sequence blocks PROPEP1 cleavage, whereas the bacterial elicitor flg22 can enhance the MC4-mediated PROPEP1 processing.	Arginine	70-78	precursor of peptide 1	Arabidopsis thaliana	101-105
20641723-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
20641847-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
17626008-8	2007	In contrast, if the substitute residue was aromatic (Trp, Tyr, and Phe) or an Arg residue at any position, Hsp70 binding affinity was maintained.	Arginine	78-81	heat shock protein family A (Hsp70) member 4	Homo sapiens	107-112
31454707-6	2019	Destruction of the catalytic cysteine residue in MC4 or the conserved arginine residue preceding the Pep1 sequence blocks PROPEP1 cleavage, whereas the bacterial elicitor flg22 can enhance the MC4-mediated PROPEP1 processing.	Arginine	70-78	precursor of peptide 1	Arabidopsis thaliana	122-129
31454707-6	2019	Destruction of the catalytic cysteine residue in MC4 or the conserved arginine residue preceding the Pep1 sequence blocks PROPEP1 cleavage, whereas the bacterial elicitor flg22 can enhance the MC4-mediated PROPEP1 processing.	Arginine	70-78	metacaspase 4	Arabidopsis thaliana	193-196
17572636-4	2007	In both the wild-type ACVR1 model and template crystal structures (TbetaRI), the conserved arginine appears to form a salt bridge with an invariant aspartate residue.	Arginine	91-99	activin A receptor type 1	Homo sapiens	22-27
31451547-7	2019	PRMT1 knockdown resulted in significant changes to 127 arginine methylation sites on 78 proteins.	Arginine	55-63	protein arginine methyltransferase 1	Homo sapiens	0-5
31451547-12	2019	Through integrative analysis of methyl forms, we identified 18 high confidence PRMT1 substrates and 12 methylation sites that are scavenged by other non-PRMT1 arginine methyltransferases in the absence of PRMT1 activity.	Arginine	159-167	protein arginine methyltransferase 1	Homo sapiens	79-84
17427197-6	2007	TGF-beta1 and high D-glucose increased hCAT-1 mRNA expression ( approximately 8-fold) and maximal transport velocity (V(max)), L-[(3)H]citrulline formation from L-[(3)H]arginine (index of NO synthesis) and endothelial NO synthase (eNOS) protein abundance, but did not alter eNOS phosphorylation.	Arginine	168-177	solute carrier family 7 member 1	Homo sapiens	39-45
17629299-9	2007	Application of heat, as used during conventional sausage manufacturing, led to a predominant alteration of arginine residues in the PLP protein and a partial loss of immunoreactivity.	Arginine	107-115	proteolipid protein 1	Homo sapiens	132-135
17635135-7	2007	At the base of TMs 2 and 3, Arg(151), His(155) and Glu(211) may form a loose equivalent of the Family A DRY (Asp-Arg-Tyr) motif.	Arginine	28-31	tropomyosin 3	Homo sapiens	15-26
17635135-7	2007	At the base of TMs 2 and 3, Arg(151), His(155) and Glu(211) may form a loose equivalent of the Family A DRY (Asp-Arg-Tyr) motif.	Arginine	113-116	tropomyosin 3	Homo sapiens	15-26
17651442-5	2007	The reaction was stimulated by fumarate (&gt; 500 microM), implicating the urea cycle enzyme argininosuccinate lyase (EC 4.3.2.1), which reversibly converts arginine and fumarate to argininosuccinate.	Arginine	157-165	argininosuccinate lyase	Arabidopsis thaliana	93-116
17462934-5	2007	RESULTS: The formerly in patients with Laron syndrome and idiopathic short stature reported mutation R179C leads to an amino acid change from an arginine residue (codon CGC) to a cysteine residue (codon TGC) in position 179 of the extracellular domain of the GHR.	Arginine	145-153	growth hormone receptor	Homo sapiens	259-262
17557828-2	2007	The arcR gene encoding ArcR forms an operon with the arginine deiminase (ADI) pathway genes arcABDC that enable the utilization of arginine as a source of energy for growth under anaerobic conditions.	Arginine	53-61	AT695_RS04040	Staphylococcus aureus	73-76
17545668-6	2007	The site-directed mutated galectin-4-R45A had diminished binding ability toward cholesterol 3-sulfate, suggesting that Arg(45) of galectin-4 is indispensable for cholesterol 3-sulfate recognition.	Arginine	119-122	galectin 4	Homo sapiens	26-36
17545668-6	2007	The site-directed mutated galectin-4-R45A had diminished binding ability toward cholesterol 3-sulfate, suggesting that Arg(45) of galectin-4 is indispensable for cholesterol 3-sulfate recognition.	Arginine	119-122	galectin 4	Homo sapiens	130-140
17493940-5	2007	The amino acid residues responsible for Smad6 sensitivity of ALK-3 were identified as Arg-238, Phe-264, Thr-265, and Ala-269, which map to the N-terminal lobe of the ALK-3 kinase domain.	Arginine	86-89	bone morphogenetic protein receptor type 1A	Homo sapiens	61-66
17493940-5	2007	The amino acid residues responsible for Smad6 sensitivity of ALK-3 were identified as Arg-238, Phe-264, Thr-265, and Ala-269, which map to the N-terminal lobe of the ALK-3 kinase domain.	Arginine	86-89	bone morphogenetic protein receptor type 1A	Homo sapiens	166-171
17592142-5	2007	Consequently, mutation of either Leu(81) or Arg(122) blocks chymotrypsin C-mediated trypsin degradation.	Arginine	44-47	chymotrypsin C	Homo sapiens	60-74
17591984-5	2007	We tested the rat isoform of NaV1.4 harboring the HypoPP mutation R663H (human R669H ortholog) at the outermost arginine of S4 in domain II for a gating-pore conductance.	Arginine	112-120	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	29-35
17483743-6	2007	In addition, CAM expressions on ECs and CD11b expression on PMNs, as well as PMN transmigration, were lower with 100 and 1000 micromol/L Arg than with 0 and 50 micromol/L Arg.	Arginine	137-140	integrin subunit alpha M	Homo sapiens	40-45
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Arginine	242-250	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	32-36
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Arginine	242-250	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	61-65
17506864-4	2007	We report here the structure of GGA1-GAE in complex with the GGA1 hinge peptide, which revealed that the two aromatic side chains of the WNSF sequence fit into a hydrophobic groove formed by aliphatic portions of the side chains of conserved arginine and lysine residues of GGA1-GAE, in a similar manner to the interaction between GGA-GAEs and acidic phenylalanine sequences from the accessory proteins.	Arginine	242-250	golgi associated, gamma adaptin ear containing, ARF binding protein 1	Homo sapiens	32-40
17556064-5	2007	In smokers, the XRCC1 Arg/Gln genotype was marginally and statistically nonsignificantly (OR = 1.5) associated with increased risk of this cancer.	Arginine	22-25	X-ray repair cross complementing 1	Homo sapiens	16-21
17439119-3	2007	They have been applied to study the oligomerization equilibrium of a low-molecular-weight protein tyrosine phosphatase in the presence of 50 mM arginine and 50 mM glutamic acid.	Arginine	144-152	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	90-118
17337454-2	2007	By inference from the crystal structure of psToc34, a homologue in pea, the arginine at residue 130 (Arg(130)) has been implicated in the formation of the atToc33 dimer and in intermolecular GTPase activation within the dimer.	Arginine	76-84	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	155-162
17337454-2	2007	By inference from the crystal structure of psToc34, a homologue in pea, the arginine at residue 130 (Arg(130)) has been implicated in the formation of the atToc33 dimer and in intermolecular GTPase activation within the dimer.	Arginine	101-104	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	155-162
17337454-7	2007	Molecular modeling using the structures of psToc34 and atToc33(R130A) suggests that, in an architectural dimer of atToc33, Arg(130) from one monomer interacts with the beta-phosphate of GDP and several other amino acids of the other monomer.	Arginine	123-126	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	55-62
17337454-7	2007	Molecular modeling using the structures of psToc34 and atToc33(R130A) suggests that, in an architectural dimer of atToc33, Arg(130) from one monomer interacts with the beta-phosphate of GDP and several other amino acids of the other monomer.	Arginine	123-126	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	114-121
17274762-5	2007	We have cloned an IPMK (inositol phosphate multikinase) from Solanum tuberosum, StIPMK (GenBank(R) accession number EF362785), that despite considerable sequence divergence from ScIPK2, restores the arginine biosynthesis pathway transcripts ARG8, acetylornithine aminotransferase, and ARG3, ornithine carbamoyltransferase of ScIpk2Delta yeast to wild-type profiles.	Arginine	199-207	inositol polyphosphate multikinase	Solanum tuberosum	18-22
17274762-5	2007	We have cloned an IPMK (inositol phosphate multikinase) from Solanum tuberosum, StIPMK (GenBank(R) accession number EF362785), that despite considerable sequence divergence from ScIPK2, restores the arginine biosynthesis pathway transcripts ARG8, acetylornithine aminotransferase, and ARG3, ornithine carbamoyltransferase of ScIpk2Delta yeast to wild-type profiles.	Arginine	199-207	inositol polyphosphate multikinase	Solanum tuberosum	24-54
17274762-5	2007	We have cloned an IPMK (inositol phosphate multikinase) from Solanum tuberosum, StIPMK (GenBank(R) accession number EF362785), that despite considerable sequence divergence from ScIPK2, restores the arginine biosynthesis pathway transcripts ARG8, acetylornithine aminotransferase, and ARG3, ornithine carbamoyltransferase of ScIpk2Delta yeast to wild-type profiles.	Arginine	199-207	inositol polyphosphate multikinase	Solanum tuberosum	80-86
17274762-6	2007	StIPMK also restores the amino acid profiles of mutant yeast to wild-type, and does so with ornithine or arginine as the sole nitrogen sources.	Arginine	105-113	inositol polyphosphate multikinase	Solanum tuberosum	0-6
17341489-7	2007	In addition, increasing the intracellular levels of arginine through overexpression of Can1p, the plasma membrane basic amino acid permease, results in increased cell volume and a severe growth defect specific to basic amino acid availability for btn1-Delta, but not wild-type cells.	Arginine	52-60	arginine permease CAN1	Saccharomyces cerevisiae S288C	87-92
17612598-4	2007	RESULTS: The expressions of nNOS mRNA and apelin receptor mRNA were both significantly increased after microinjection of L-Arg, but significantly decreased after microinjection of L-NAME compared with the NS control group.	Arginine	121-126	nitric oxide synthase 1	Rattus norvegicus	28-32
17612598-4	2007	RESULTS: The expressions of nNOS mRNA and apelin receptor mRNA were both significantly increased after microinjection of L-Arg, but significantly decreased after microinjection of L-NAME compared with the NS control group.	Arginine	121-126	apelin receptor	Rattus norvegicus	42-57
17612598-5	2007	The nNOS mRNA had a positive correlation with the expression of apelin receptor mRNA after microinjection of L-Arg and L-NAME.	Arginine	109-114	nitric oxide synthase 1	Rattus norvegicus	4-8
17612598-5	2007	The nNOS mRNA had a positive correlation with the expression of apelin receptor mRNA after microinjection of L-Arg and L-NAME.	Arginine	109-114	apelin receptor	Rattus norvegicus	64-79
17320064-6	2007	Nitric oxide is synthesized from l-arginine via the enzyme, NO synthase (NOS), which exists in 3 isoforms: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS).	Arginine	33-43	nitric oxide synthase 1	Rattus norvegicus	137-141
31451547-12	2019	Through integrative analysis of methyl forms, we identified 18 high confidence PRMT1 substrates and 12 methylation sites that are scavenged by other non-PRMT1 arginine methyltransferases in the absence of PRMT1 activity.	Arginine	159-167	protein arginine methyltransferase 1	Homo sapiens	153-158
31451547-12	2019	Through integrative analysis of methyl forms, we identified 18 high confidence PRMT1 substrates and 12 methylation sites that are scavenged by other non-PRMT1 arginine methyltransferases in the absence of PRMT1 activity.	Arginine	159-167	protein arginine methyltransferase 1	Homo sapiens	153-158
31492697-2	2019	To check wheth er peptides built exclusively from arginine residues will interact with different nAChR subtypes or with such their structural homologues as the acetylcholine binding protein and ligand binding domain of nAChR alpha9 subunit, we synthesized a series of R3, R6, R8 and R16 oligoarginines and investigate their activity by competition with radioiodinated alpha- bungarotoxin, by two electrode voltage clamp electrophysiology and calcium imaging.	Arginine	50-58	solute carrier family 1 member 5	Homo sapiens	283-286
31624244-5	2019	Furthermore, we show that UHRF1 interacts with PRMT5, an arginine methyltransferase, to regulate the repressive histone arginine modifications (H4R3me2s and H3R2me2s), and cooperates with the PIWI pathway during spermatogenesis.	Arginine	57-65	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	26-31
17337448-9	2007	A second site at Arg(459) decreasing Gly(460) within the C-terminal helicase region of NS3 was cleaved more slowly.	Arginine	17-20	KRAS proto-oncogene, GTPase	Homo sapiens	87-90
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	45-53	peptidyl arginine deiminase 2	Homo sapiens	110-114
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	45-53	peptidyl arginine deiminase 3	Homo sapiens	116-120
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	68-76	peptidyl arginine deiminase 2	Homo sapiens	110-114
17303166-7	2007	Using synthetic peptides that contain either arginine or methylated arginine residues, we show that the human PAD2, PAD3 and PAD4 enzymes and PAD enzyme present in several mouse tissues in vitro can only convert non-methylated peptidylarginine into peptidylcitrulline and that hPAD6 does not show any deiminating activity at all.	Arginine	68-76	peptidyl arginine deiminase 3	Homo sapiens	116-120
31391274-5	2019	UL31 residues arginine-281 (R281) and aspartic acid-282 (D282) were required for efficient NEC binding to nucleocapsids and UL25.	Arginine	14-22	DNA packaging tegument protein UL25	Human alphaherpesvirus 1	124-128
17211892-4	2007	We report that the ARG core domain is homologous to the corresponding ABL region, therefore suggesting that ARG catalytic activity is likely regulated by the same SH3-SH2 clamp described for ABL.	Arginine	19-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	70-73
17211892-4	2007	We report that the ARG core domain is homologous to the corresponding ABL region, therefore suggesting that ARG catalytic activity is likely regulated by the same SH3-SH2 clamp described for ABL.	Arginine	19-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	191-194
17211892-4	2007	We report that the ARG core domain is homologous to the corresponding ABL region, therefore suggesting that ARG catalytic activity is likely regulated by the same SH3-SH2 clamp described for ABL.	Arginine	108-111	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	70-73
31297861-6	2019	This variant results in a change of a glycine (Gly) to an arginine (Arg) at amino acid position 126 (c.376G&gt;A), occurring in the second Ig-like domain of the extracellular domain of KIT.	Arginine	58-66	mast/stem cell growth factor receptor Kit	Vicugna pacos	185-188
17211892-4	2007	We report that the ARG core domain is homologous to the corresponding ABL region, therefore suggesting that ARG catalytic activity is likely regulated by the same SH3-SH2 clamp described for ABL.	Arginine	108-111	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	191-194
17211892-9	2007	Finally, our analyses show that the C-terminal actin-binding domain of ARG displays a four-helix bundle structure similar to the one reported for the corresponding ABL region.	Arginine	71-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	164-167
17311413-9	2007	The deleted region contains arginine-rich sequences, as found in other RNA-binding proteins, and may function by tethering CYT-19 to structured RNAs, so that it can efficiently disrupt exposed, non-native structural elements, allowing them to refold.	Arginine	28-36	arsenite methyltransferase	Homo sapiens	123-129
31297861-6	2019	This variant results in a change of a glycine (Gly) to an arginine (Arg) at amino acid position 126 (c.376G&gt;A), occurring in the second Ig-like domain of the extracellular domain of KIT.	Arginine	68-71	mast/stem cell growth factor receptor Kit	Vicugna pacos	185-188
31169351-13	2019	Taken together, our data manifested that miR-27 repressed cardiomyocyte injury induced by H/R via mediating TGFBR1 and inhibiting NF-kappaB signaling pathway.	Arginine	43-44	transforming growth factor, beta receptor 1	Rattus norvegicus	108-114
17198704-2	2007	Argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and nNOS act in the L-arginine-NO-L-citrulline cycle permitting a correct NO production.	Arginine	86-96	nitric oxide synthase 1	Rattus norvegicus	70-74
31643170-2	2019	In a study in the mouse model of L-arginine-induced acute pancreatitis, we showed that BRB administered by the intravenous route at 0.1 and 0.5 mg / kg body weight significantly reduces the level of myeloperoxidase activity (an indicator of inflammation) in the pancreas and lungs.	Arginine	33-43	myeloperoxidase	Mus musculus	199-214
17352736-5	2007	Importantly, cell lines lacking the FANCL or FANCD2 genes, or carrying a "knock-in" mutation of the FancD2 monoubiquitination site (where the Lys 563 residue is changed to Arg), displayed quantitatively identical defects in the repair of I-SceI-induced chromosomal breaks by homologous recombination (HR).	Arginine	172-175	Fanconi anemia complementation group D2	Gallus gallus	100-106
17188401-1	2007	We demonstrated recently that selective side-chain modification of functional cysteine-rich (Tat(21-40)) and arginine-rich (Tat(53-68)) domains of the HIV-1 Tat protein blocks pathogenic activities of these peptides while retaining their immunological characteristics.	Arginine	109-117	Tat	Human immunodeficiency virus 1	124-127
31302167-4	2019	Arginine 51 of S100A3 protein is citrullinated specifically by peptidylarginine deiminase 3 (PAD3), and this citrullination is related to maturation of the cuticle.	Arginine	0-8	peptidyl arginine deiminase 3	Homo sapiens	63-91
17188401-1	2007	We demonstrated recently that selective side-chain modification of functional cysteine-rich (Tat(21-40)) and arginine-rich (Tat(53-68)) domains of the HIV-1 Tat protein blocks pathogenic activities of these peptides while retaining their immunological characteristics.	Arginine	109-117	Tat	Human immunodeficiency virus 1	124-127
31302167-4	2019	Arginine 51 of S100A3 protein is citrullinated specifically by peptidylarginine deiminase 3 (PAD3), and this citrullination is related to maturation of the cuticle.	Arginine	0-8	peptidyl arginine deiminase 3	Homo sapiens	93-97
31295473-5	2019	The functional and kinetic characterization of glutamine and arginine transport was performed using human SLC38A9 produced in E. coli, purified by affinity chromatography and reconstituted in liposomes.	Arginine	61-69	solute carrier family 38 member 9	Homo sapiens	106-113
17118335-3	2007	In the second case, a missense mutation in COL1A1 (substitution of arginine by cysteine) results in a type I EDS phenotype with clinically normal-appearing dentition.	Arginine	67-75	collagen type I alpha 1 chain	Homo sapiens	43-49
31295473-10	2019	Different features for glutamine and arginine transport were revealed: human SLC38A9 is competent for glutamine efflux, while that of arginine is negligible.	Arginine	37-45	solute carrier family 38 member 9	Homo sapiens	77-84
31133753-5	2019	Following activation of CD4+ T cells, however, N4BP1 undergoes rapid cleavage at Arg 509 by the paracaspase named mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1).	Arginine	81-84	NEDD4 binding protein 1	Homo sapiens	47-52
16949794-3	2007	Primary sequence analysis indicated that the Rap1GAP2 GoLoco motif contains a lysine (Lys-75), rather than an arginine, at the crucial residue responsible for binding the alpha and beta phosphates of GDP and exerting GDI activity.	Arginine	110-118	RAP1 GTPase activating protein 2	Homo sapiens	45-53
31474872-7	2019	Moreover, silencing Arg-II prevented the ICAM-1 upregulation induced by hypoxia or DMOG.	Arginine	20-23	intercellular adhesion molecule 1	Homo sapiens	41-47
17365664-5	2007	Abeta-treated BBECs showed spontaneous NO production in the presence of L-arginine.	Arginine	72-82	amyloid beta precursor protein	Rattus norvegicus	0-5
31179625-1	2019	SERPINH1 encodes the collagen chaperone HSP47 that binds to arginine-rich sequences in the type I procollagen trimers and provides the final steps in the folding and stabilization of the triple helical domain.	Arginine	60-68	serpin family H member 1	Homo sapiens	0-8
17095285-18	2007	In the case of XRCC1, laboratory workers with 399Arg/Gln or Gln/Gln had a lower DNA-repair capacity--measured as radiation-induced frequency of dicentrics and deletions--than those with the 399Arg/Arg genotype (p&lt;0.01).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	15-20
31179625-1	2019	SERPINH1 encodes the collagen chaperone HSP47 that binds to arginine-rich sequences in the type I procollagen trimers and provides the final steps in the folding and stabilization of the triple helical domain.	Arginine	60-68	serpin family H member 1	Homo sapiens	40-45
30861207-9	2019	A beneficial effect of c-Abl kinase inhibition was confirmed in l-arginine-induced pancreatitis.	Arginine	64-74	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	23-28
17077965-3	2007	We found a significantly (P &lt; 0.05) higher degradation of L-arginine in 0.5 M AAc compared with that of DEMI H(2)O.	Arginine	61-71	glycine-N-acyltransferase	Homo sapiens	81-84
31147442-3	2019	JMJD6 is also reported to catalyze N-demethylation of N-methylated (both mono- and di-methylated) arginine residues of histones and other proteins, including HSP70 (heat-shock protein 70), estrogen receptor alpha, and RNA helicase A.	Arginine	98-106	heat shock protein family A (Hsp70) member 4	Homo sapiens	158-163
16889986-2	2007	Two common single nucleotide polymorphisms (SNPs) that code for the substitution of conserved arginine residues have previously been identified in FRZB and found to be associated with osteoarthritis (OA).	Arginine	94-102	frizzled related protein	Homo sapiens	147-151
16889986-3	2007	Functional studies revealed that the arginine substitutions lead to a loss-of-function of sFRP3 activity.	Arginine	37-45	frizzled related protein	Homo sapiens	90-95
31147442-3	2019	JMJD6 is also reported to catalyze N-demethylation of N-methylated (both mono- and di-methylated) arginine residues of histones and other proteins, including HSP70 (heat-shock protein 70), estrogen receptor alpha, and RNA helicase A.	Arginine	98-106	heat shock protein family A (Hsp70) member 4	Homo sapiens	165-186
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Arginine	45-55	glycine amidinotransferase	Homo sapiens	84-119
17497436-1	2007	This study was designed to determine the effect of L-arginine on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of ischemia/reperfusion (I/R) injury.	Arginine	51-61	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	97-108
31028716-1	2019	l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT).	Arginine	45-55	glycine amidinotransferase	Homo sapiens	121-125
17497436-1	2007	This study was designed to determine the effect of L-arginine on hypoxia inducible factor alpha (HIF-1 alpha) and Sonic hedgehog (Shh) levels considered to be involved in the development of ischemia/reperfusion (I/R) injury.	Arginine	51-61	sonic hedgehog signaling molecule	Rattus norvegicus	114-128
17497436-6	2007	The Shh expression in the tubulus epithelia were intensely increased in the I-R/L-Arg group when compared to that of the Sham-control and the I-R/untreated groups.	Arginine	82-85	sonic hedgehog signaling molecule	Rattus norvegicus	4-7
17497436-7	2007	Additionally, the HIF-1alpha expression in the tubulus epithelia and the interstitial spaces were intensely increased in the I-R/L-Arg group.	Arginine	131-134	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	18-28
31379950-0	2019	Histone Arginine Methylation-Mediated Epigenetic Regulation of Discoidin Domain Receptor 2 Controls the Senescence of Human Bone Marrow Mesenchymal Stem Cells.	Arginine	8-16	discoidin domain receptor tyrosine kinase 2	Homo sapiens	63-90
17015450-3	2006	The human PEPCK crystal structure suggests that Asp(78) influences Tyr(220); Tyr(220) helps to position bound PEP, and Glu(83) interacts with Arg(81).	Arginine	142-145	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	10-15
31379950-7	2019	Finally, chromatin immunoprecipitation analysis confirmed direct binding of CARM1 to the DDR2 promoter region with a high level of H3R17 methylation in early-passage hBM-MSCs, and inhibition of CARM1-mediated histone arginine methylation decreased DDR2 expression and led to cellular senescence.	Arginine	217-225	coactivator associated arginine methyltransferase 1	Homo sapiens	76-81
31379950-7	2019	Finally, chromatin immunoprecipitation analysis confirmed direct binding of CARM1 to the DDR2 promoter region with a high level of H3R17 methylation in early-passage hBM-MSCs, and inhibition of CARM1-mediated histone arginine methylation decreased DDR2 expression and led to cellular senescence.	Arginine	217-225	discoidin domain receptor tyrosine kinase 2	Homo sapiens	89-93
31098988-2	2019	We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which has a PDZ motif (Thr-Arg-Leu), by yeast two-hybrid screening and revealed that PDZK1 enhances the transport activity of SMCT1.	Arginine	138-141	PDZ domain containing 1	Homo sapiens	19-24
16886222-2	2006	Starting with a foundation consisting of an environmentally responsive poly(N-isopropylacrylamide-co-acrylic acid) hydrogel, we incorporated matrix metalloproteinase-13 (MMP-13) degradable crosslinkers and peptides containing integrin-binding domains (i.e., Arg-Gly-Asp) to create a biomimetic matrix designed to encourage osteoblast migration and proliferation.	Arginine	258-261	matrix metallopeptidase 13	Rattus norvegicus	170-176
31098988-2	2019	We have identified PDZK1 and PDZ domain-containing RING finger 3 (PDZRN3) as potent binding partners of SMCT1, which has a PDZ motif (Thr-Arg-Leu), by yeast two-hybrid screening and revealed that PDZK1 enhances the transport activity of SMCT1.	Arginine	138-141	solute carrier family 5 member 8	Homo sapiens	104-109
17122583-1	2006	BACKGROUND: L-Arginine transport mediated by type 2 cationic amino acid transporter (CAT-2) is one crucial mechanism that regulates nitric oxide production mediated by inducible nitric oxide synthase.	Arginine	12-22	dominant cataract 2	Mus musculus	85-90
30956113-0	2019	Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.	Arginine	45-53	transmembrane 4 L six family member 5	Homo sapiens	0-37
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	117-125	transmembrane 4 L six family member 5	Homo sapiens	19-56
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	117-125	transmembrane 4 L six family member 5	Homo sapiens	58-64
17019704-3	2006	These results reveal that the carboxylate of the omega-carboxyalkyloxy side chain of these inhibitors form ionic interactions with the conserved Arg in the substrate binding pocket of DHFR.	Arginine	145-148	dihydrofolate reductase	Mus musculus	184-188
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	149-157	transmembrane 4 L six family member 5	Homo sapiens	19-56
17010310-2	2006	Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three RNA recognition motifs, and an Arg/Gly-rich region.	Arginine	182-185	APOBEC1 complementation factor	Homo sapiens	29-59
30956113-3	2019	Here, we show that transmembrane 4 L six family member 5 (TM4SF5) translocates from plasma membrane to lysosome upon arginine sufficiency and senses arginine, culminating in mTORC1/S6K1 activation.	Arginine	149-157	transmembrane 4 L six family member 5	Homo sapiens	58-64
30956113-4	2019	TM4SF5 bound active mTOR upon arginine sufficiency and constitutively bound amino acid transporter SLC38A9.	Arginine	30-38	transmembrane 4 L six family member 5	Homo sapiens	0-6
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	32-40	transmembrane 4 L six family member 5	Homo sapiens	0-6
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	32-40	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	48-55
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	32-40	transmembrane 4 L six family member 5	Homo sapiens	107-113
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	71-79	transmembrane 4 L six family member 5	Homo sapiens	0-6
16865671-7	2006	However, patients with the XRCC1 399 Gln allele, that results in a lower base excision repair capacity, were more likely to have p53 mutations, compared with patients the wild-type Arg allele (P = 0.03).	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	27-32
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	71-79	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	48-55
30956113-5	2019	TM4SF5 binding to the cytosolic arginine sensor Castor1 decreased upon arginine sufficiency, thus allowing TM4SF5-mediated sensing of metabolic amino acids.	Arginine	71-79	transmembrane 4 L six family member 5	Homo sapiens	107-113
30956113-6	2019	TM4SF5 directly bound free L-arginine via its extracellular loop possibly for the efflux, being supported by mutant study and homology and molecular docking modeling.	Arginine	27-37	transmembrane 4 L six family member 5	Homo sapiens	0-6
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	63-71	transmembrane 4 L six family member 5	Homo sapiens	37-43
17073300-9	2006	This iterative bioinformatic-experimental approach to a comprehensive analysis of the HrpL regulon revealed a mix of genes controlled by HrpL, including those encoding most type III effectors, twin-arginine transport (TAT) substrates, other regulatory proteins, and proteins involved in the synthesis or metabolism of phytohormones, phytotoxins, and myo-inositol.	Arginine	198-206	RNA polymerase sigma factor HrpL	Pseudomonas syringae pv. tomato str. DC3000	86-90
17073300-9	2006	This iterative bioinformatic-experimental approach to a comprehensive analysis of the HrpL regulon revealed a mix of genes controlled by HrpL, including those encoding most type III effectors, twin-arginine transport (TAT) substrates, other regulatory proteins, and proteins involved in the synthesis or metabolism of phytohormones, phytotoxins, and myo-inositol.	Arginine	198-206	RNA polymerase sigma factor HrpL	Pseudomonas syringae pv. tomato str. DC3000	137-141
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	63-71	transmembrane 4 L six family member 5	Homo sapiens	218-224
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	111-119	transmembrane 4 L six family member 5	Homo sapiens	37-43
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	111-119	transmembrane 4 L six family member 5	Homo sapiens	218-224
30956113-7	2019	Therefore, we propose that lysosomal TM4SF5 senses and enables arginine efflux for mTORC1/S6K1 activation, and arginine-auxotroph in hepatocellular carcinoma may be targeted by blocking the arginine sensing using anti-TM4SF5 reagents.	Arginine	111-119	transmembrane 4 L six family member 5	Homo sapiens	37-43
31217904-9	2019	We also show that YY1 is a substrate of CARM1 mediated arginine methylation, where the latter could coactivate YY1 mediated reporter gene activation in vivo.	Arginine	55-63	coactivator associated arginine methyltransferase 1	Homo sapiens	40-45
16935856-6	2006	Consistent with results on record, we observed that FXa-1.5-dansyl-Glu-Gly-Arg decreased the Arg-506 cleavage by 20-fold, with a half-maximum inhibition of approximately 2 nM.	Arginine	75-78	coagulation factor X	Homo sapiens	52-55
16935856-7	2006	Interestingly and in contrast to the inhibitory effect of FXa on the 506 cleavage, FXa stimulated the Arg-306 cleavage.	Arginine	102-105	coagulation factor X	Homo sapiens	83-86
16935856-8	2006	Protein S counteracted the inhibition by FXa of the Arg-506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg-306.	Arginine	52-55	coagulation factor X	Homo sapiens	41-44
16935856-8	2006	Protein S counteracted the inhibition by FXa of the Arg-506 cleavage, whereas protein S and FXa yielded additive stimulatory effect of the cleavage at Arg-306.	Arginine	151-154	coagulation factor X	Homo sapiens	92-95
31076514-5	2019	We demonstrate that the change to an arginine residue at position 32 represents an additional activation site used by furin-like proteases in the Golgi, which consequently leads to reduced shedding by ADAM17.	Arginine	37-45	ADAM metallopeptidase domain 17	Homo sapiens	201-207
16935856-9	2006	This suggests that FXa and protein S interact with distinct sites on FVa, which is consistent with the observed lack of inhibitory effect on FXa binding to FVa by protein S. We propose that the apparent annihilation of the FXa protection of the Arg-506 cleavage by protein S is due to an enhanced rate of Arg-506 cleavage of FVa not bound to FXa, resulting in depletion of free FVa and dissociation of FXa-FVa complexes.	Arginine	245-248	coagulation factor X	Homo sapiens	19-22
16935856-9	2006	This suggests that FXa and protein S interact with distinct sites on FVa, which is consistent with the observed lack of inhibitory effect on FXa binding to FVa by protein S. We propose that the apparent annihilation of the FXa protection of the Arg-506 cleavage by protein S is due to an enhanced rate of Arg-506 cleavage of FVa not bound to FXa, resulting in depletion of free FVa and dissociation of FXa-FVa complexes.	Arginine	305-308	coagulation factor X	Homo sapiens	19-22
17038548-6	2006	Our results suggest that the Arg-based signal present in Kir6.2 is sterically masked by the SUR1 subunit.	Arginine	29-32	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	57-63
30909017-0	2019	Label-free impedimetric immunosensor based on arginine-functionalized gold nanoparticles for detection of DHEAS, a biomarker of pediatric adrenocortical carcinoma.	Arginine	46-54	sulfotransferase family 2A member 1	Homo sapiens	106-111
16916800-0	2006	Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity.	Arginine	94-102	ornithine decarboxylase antizyme 1	Mus musculus	51-59
30909017-3	2019	Therefore, the present paper reports, for the first time, the construction and application of a label-free impedimetric immunosensor to detect DHEAS, which was based on the modification of an oxidized glassy carbon electrode with arginine-functionalized gold nanoparticles (AuNPs-ARG) and anti-DHEA IgM antibodies (ox-GCE/AuNPs-ARG/IgM).	Arginine	230-238	sulfotransferase family 2A member 1	Homo sapiens	143-148
17014440-7	2006	Substrate specificity of equine tryptase was investigated using arginine and lysine containing substrates.	Arginine	64-72	proto-oncogene tyrosine-protein kinase receptor Ret	Equus caballus	32-40
30909017-3	2019	Therefore, the present paper reports, for the first time, the construction and application of a label-free impedimetric immunosensor to detect DHEAS, which was based on the modification of an oxidized glassy carbon electrode with arginine-functionalized gold nanoparticles (AuNPs-ARG) and anti-DHEA IgM antibodies (ox-GCE/AuNPs-ARG/IgM).	Arginine	280-283	sulfotransferase family 2A member 1	Homo sapiens	143-148
17014440-9	2006	Unusually for a trypsin-like proteinase however, equine tryptase has alanine at residue 216, rather than glycine, which confers increased arginine substrate specificity in vitro and may restrict fibrinogenolysis in vivo.	Arginine	138-146	proto-oncogene tyrosine-protein kinase receptor Ret	Equus caballus	56-64
30909017-3	2019	Therefore, the present paper reports, for the first time, the construction and application of a label-free impedimetric immunosensor to detect DHEAS, which was based on the modification of an oxidized glassy carbon electrode with arginine-functionalized gold nanoparticles (AuNPs-ARG) and anti-DHEA IgM antibodies (ox-GCE/AuNPs-ARG/IgM).	Arginine	328-331	sulfotransferase family 2A member 1	Homo sapiens	143-148
30909017-10	2019	The promising analytical performance of ox-GCE/AuNPs-ARG/IgM was confirmed by quantifying DHEAS in real patient plasma samples, with results that were comparable to the reference chemiluminescence assay.	Arginine	53-56	sulfotransferase family 2A member 1	Homo sapiens	90-95
30698750-0	2019	Conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks.	Arginine	39-42	SDE2 telomere maintenance homolog	Homo sapiens	27-31
16964423-0	2006	Effects of lysine to arginine mutations in HIV-1 Vif on its expression and viral infectivity.	Arginine	21-29	Vif	Human immunodeficiency virus 1	49-52
16964423-4	2006	When all the lysines were changed to arginines, the mutant Vif was expressed in cells at much higher level than wt and was much more stable.	Arginine	37-46	Vif	Human immunodeficiency virus 1	59-62
16822869-9	2006	These data suggest that highly conserved arginine and histidine residues may compensate for variation elsewhere in the a1 and a2 plasminogen binding repeats, and may explain the maintenance of high affinity plasminogen binding by naturally occurring variants of PAM.	Arginine	41-49	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	262-265
30698750-4	2019	Lys-SDE2Ct constitutes a short-lived physiological substrate of the Arg/N-end rule proteolytic pathway, in which UBR1 and UBR2 ubiquitin ligases mediate the degradation.	Arginine	68-71	SDE2 telomere maintenance homolog	Homo sapiens	4-8
30698750-4	2019	Lys-SDE2Ct constitutes a short-lived physiological substrate of the Arg/N-end rule proteolytic pathway, in which UBR1 and UBR2 ubiquitin ligases mediate the degradation.	Arginine	68-71	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	113-117
30698750-5	2019	The Arg/N-end rule and VCP/p97UFD1-NPL4 segregase cooperate to promote phosphorylation-dependent, chromatin-associated Lys-SDE2Ct degradation upon UVC damage.	Arginine	4-7	SDE2 telomere maintenance homolog	Homo sapiens	123-127
30796035-3	2019	Preclinically, we showed that HGGs are a target for arginine depletion with pegargiminase (ADI-PEG20) due to epimutations of argininosuccinate synthetase (ASS1) and/or argininosuccinate lyase (ASL).	Arginine	52-60	argininosuccinate lyase	Homo sapiens	168-191
16844694-4	2006	Structure and function analysis of RLF derivatives with single amino acid replacements revealed that the most important binding residues are tryptophan B27, followed by arginine B16 and valine B19.	Arginine	169-177	RLF zinc finger	Homo sapiens	35-38
30913349-0	2019	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1-7)/Mas Receptor Axis.	Arginine	52-55	angiotensin I converting enzyme 2	Rattus norvegicus	127-131
30913349-0	2019	Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1-7)/Mas Receptor Axis.	Arginine	52-55	angiogenin	Rattus norvegicus	132-135
31058095-5	2019	Although peptidyl arginine deiminase-2 and -4 (PADI2 and PADI4, respectively) can catalyze the conversion of arginine to citrulline, we observed that only PADI4 expression correlated with the citrulline histone modification of H3R26Cit.	Arginine	18-26	peptidyl arginine deiminase 2	Homo sapiens	47-52
31057398-6	2019	Also, the eNOS substrate L-arginine reversed the inhibition effect of L-NAME on THP-induced vascular relaxation.	Arginine	25-35	nitric oxide synthase 3	Rattus norvegicus	10-14
30802433-3	2019	Purified recombinant PRMT7 displays a number of unique enzymatic properties including a substrate preference for arginine residues in R-X-R motifs with additional flanking basic amino acid residues and a temperature optimum well below 37  C. Evidence has been presented for crosstalk between PRMT7 and PRMT5, where methylation of a histone H4 peptide at R17, a PRMT7 substrate, may activate PRMT5 for methylation of R3.	Arginine	113-121	protein arginine methyltransferase 7	Homo sapiens	21-26
30783866-8	2019	Arg or Asp was identified as a catalytic site in plasmodium IspD homologs, contributing a direct role in the cytidylyltransferase activity similar to bacterial IspD.	Arginine	0-3	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	160-164
30699057-2	2019	PRMT7 is the single type III PRMT solely capable of arginine monomethylation.	Arginine	52-60	protein arginine methyltransferase 7	Homo sapiens	0-5
30699057-6	2019	Furthermore, we uncovered a potential regulatory interplay between eIF2alpha arginine methylation by PRMT7 and stress-induced phosphorylation status of eIF2alpha at serine 51.	Arginine	77-85	eukaryotic translation initiation factor 2A	Homo sapiens	67-76
30699057-6	2019	Furthermore, we uncovered a potential regulatory interplay between eIF2alpha arginine methylation by PRMT7 and stress-induced phosphorylation status of eIF2alpha at serine 51.	Arginine	77-85	protein arginine methyltransferase 7	Homo sapiens	101-106
30865893-0	2019	p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.	Arginine	96-104	solute carrier family 7 member 3	Homo sapiens	77-83
30791488-2	2019	This work focused on the characterization of the CAT2 transporter from S. lycopersicum (SlCAT2) that was previously overexpressed in E. coli and reconstituted in proteoliposomes for transport assay as [3H]Arg uptake.	Arginine	205-208	catalase isozyme 2	Solanum lycopersicum	49-53
30791488-2	2019	This work focused on the characterization of the CAT2 transporter from S. lycopersicum (SlCAT2) that was previously overexpressed in E. coli and reconstituted in proteoliposomes for transport assay as [3H]Arg uptake.	Arginine	205-208	catalase isozyme 2	Solanum lycopersicum	88-94
30717826-6	2019	However, Vpu-mediated inhibition of immune activation required an arginine residue in the cytoplasmic domain that is critical for blocking NF-kappaB signaling downstream of tetherin.	Arginine	66-74	bone marrow stromal cell antigen 2	Homo sapiens	173-181
30881620-3	2019	Our previous SAR studies of compounds, showing affinity for NRP-1, led us to develop branched peptides with general formula Lys(hArg)-AA2-AA3-Arg.	Arginine	129-132	AA2	Homo sapiens	134-137
30472187-2	2019	Here, we identify a new modification at the CTD, the deimination of arginine and its conversion to citrulline by peptidyl arginine deiminase 2 (PADI2), an enzyme that has been associated with several diseases, including cancer.	Arginine	68-76	peptidyl arginine deiminase 2	Homo sapiens	113-142
30472187-2	2019	Here, we identify a new modification at the CTD, the deimination of arginine and its conversion to citrulline by peptidyl arginine deiminase 2 (PADI2), an enzyme that has been associated with several diseases, including cancer.	Arginine	68-76	peptidyl arginine deiminase 2	Homo sapiens	144-149
30613774-5	2019	In addition, their arginine concentrations reverse the urea cycle reaction catalyzed by argininosuccinate lyase, an effect not observed in vivo, and prevented by Plasmax in vitro.	Arginine	19-27	argininosuccinate lyase	Homo sapiens	88-111
31711377-5	2019	We found that the GII.3 huNoV binds HBGAs via a conventional GII HBS that uses an arginine instead of the conserved aromatic residue for the required Van der Waals interaction, while the GII.11 porNoV HBS loses its HBGA-binding function because of two mutations (Q355/V451).	Arginine	82-90	hemoglobin subunit gamma 1	Homo sapiens	36-40
30625464-11	2019	Sequencing of SLC29A3 in the three siblings revealed a novel homozygous mutation in exon 6, which caused the transition of arginine to tryptophan.	Arginine	123-131	solute carrier family 29 member 3	Homo sapiens	14-21
30191588-7	2019	Furthermore, bioinformatics analysis revealed that arginine (Arg) to tryptophan (Trp) substitution at rs2278426 position causes structural instability of ANGPTL8 protein.	Arginine	61-64	angiopoietin like 8	Homo sapiens	154-161
30844146-7	2019	The haplotypes of XRCC1 T-Arg-Arg-Gln and XRCC1 C-Arg-Arg-Arg were positively associated with the NSCLC occurrence in nonsmoking female patients.	Arginine	26-29	X-ray repair cross complementing 1	Homo sapiens	18-23
16961918-1	2006	BACKGROUND: We have reported arginine-sensitive regulation of LAT1 amino acid transporter (SLC 7A5) in normal rodent hepatic cells with loss of arginine sensitivity and high level constitutive expression in tumor cells.	Arginine	29-37	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	62-66
16961918-1	2006	BACKGROUND: We have reported arginine-sensitive regulation of LAT1 amino acid transporter (SLC 7A5) in normal rodent hepatic cells with loss of arginine sensitivity and high level constitutive expression in tumor cells.	Arginine	29-37	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	91-98
16961918-1	2006	BACKGROUND: We have reported arginine-sensitive regulation of LAT1 amino acid transporter (SLC 7A5) in normal rodent hepatic cells with loss of arginine sensitivity and high level constitutive expression in tumor cells.	Arginine	144-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	62-66
16961918-1	2006	BACKGROUND: We have reported arginine-sensitive regulation of LAT1 amino acid transporter (SLC 7A5) in normal rodent hepatic cells with loss of arginine sensitivity and high level constitutive expression in tumor cells.	Arginine	144-152	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	91-98
16730327-9	2006	Early expression of BAC1 and BAC2 is consistent with the delivery of arginine, released from seed reserves, to mitochondrial arginase and the export of ornithine.	Arginine	69-77	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	20-24
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	197-200	X-ray repair cross complementing 1	Homo sapiens	190-195
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	X-ray repair cross complementing 1	Homo sapiens	190-195
16569655-10	2006	The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.	Arginine	201-204	X-ray repair cross complementing 1	Homo sapiens	190-195
16889659-14	2006	Arginine-83 of yeast Vps25p involved in Vps22p interaction was highly, but not absolutely, conserved.	Arginine	0-8	ESCRT-II subunit protein SNF8	Saccharomyces cerevisiae S288C	40-46
16820567-2	2006	Preliminary microarray analysis revealed a significant and unexpected decrease in myocardial arginine:glycine amidinotransferase (AGAT) gene expression during recovery in these patients.	Arginine	93-101	glycine amidinotransferase	Homo sapiens	130-134
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
16734667-4	2006	This reporter reveals that the Arg-based ER localization signals from mammalian Kir6.2 and GB1 proteins are functional in yeast.	Arginine	31-34	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	80-86
16734667-4	2006	This reporter reveals that the Arg-based ER localization signals from mammalian Kir6.2 and GB1 proteins are functional in yeast.	Arginine	31-34	gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	91-94
16734667-6	2006	Multimeric presentation of the Arg-based signal from Kir6.2 on Pmp2p results in forward transport, which requires 14-3-3 proteins encoded in yeast by BMH1 and BMH2 in two isoforms.	Arginine	31-34	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	53-59
16819283-3	2006	One KCNRG missense mutation, CGT CAT (Arg His) was found at codon 92 within the T1 domain.	Arginine	38-41	UDP glycosyltransferase 8	Homo sapiens	29-32
16892511-0	2006	Letter to the editor re: JAMA article on L-arginine therapy in acute myocardial infarction.	Arginine	41-51	F11 receptor	Homo sapiens	25-29
16703566-10	2006	The data show that a large increase in a specific transport system (CAT2) is necessary for activation-induced arginine metabolism, while arginine is in excess for the requirements of proliferation and a modest increase in transport occurs.	Arginine	110-118	dominant cataract 2	Mus musculus	68-72
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	basic helix-loop-helix family member e41	Homo sapiens	70-74
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	basic helix-loop-helix family member e41	Homo sapiens	124-128
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	basic helix-loop-helix family member e41	Homo sapiens	124-128
16685415-4	2006	A luciferase assay showed that substituting (57)Arg for Ala or Lys in DEC2 diminished the suppressive activity of wild-type DEC2 on CLOCK/ BMAL2-mediated transactivation, while substituting (48)Pro for Ala in DEC2 did not alter it, and the same was true for wild-type DEC2.	Arginine	48-51	basic helix-loop-helix family member e41	Homo sapiens	124-128
16685415-6	2006	These findings demonstrate that (57)Arg in the basic region of DEC2 is essential for its activity in suppressing CLOCK/BMAL2-mediated transactivation.	Arginine	36-39	basic helix-loop-helix family member e41	Homo sapiens	63-67
30844146-7	2019	The haplotypes of XRCC1 T-Arg-Arg-Gln and XRCC1 C-Arg-Arg-Arg were positively associated with the NSCLC occurrence in nonsmoking female patients.	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	18-23
30844146-7	2019	The haplotypes of XRCC1 T-Arg-Arg-Gln and XRCC1 C-Arg-Arg-Arg were positively associated with the NSCLC occurrence in nonsmoking female patients.	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	18-23
30844146-7	2019	The haplotypes of XRCC1 T-Arg-Arg-Gln and XRCC1 C-Arg-Arg-Arg were positively associated with the NSCLC occurrence in nonsmoking female patients.	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	18-23
30844146-7	2019	The haplotypes of XRCC1 T-Arg-Arg-Gln and XRCC1 C-Arg-Arg-Arg were positively associated with the NSCLC occurrence in nonsmoking female patients.	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	18-23
30253213-7	2018	In line with computational studies, biosensor-based structure-kinetic relationship studies demonstrated that 6-O-sulfo groups of d-glucosamine residue were essential in binding to arginines of both TLR4 and MD2 domains of the receptor complex.	Arginine	180-189	lymphocyte antigen 96	Homo sapiens	207-210
30071355-4	2018	ARG carriage was investigated by the double-disk synergy test, metallo-beta-lactamase (MBL) production test and PCR screening for carbapenemase genes.	Arginine	0-3	NDM-1	Escherichia coli	63-85
30071355-4	2018	ARG carriage was investigated by the double-disk synergy test, metallo-beta-lactamase (MBL) production test and PCR screening for carbapenemase genes.	Arginine	0-3	NDM-1	Escherichia coli	87-90
30341438-0	2018	Arginine auxotrophy in PKD.	Arginine	0-8	protein kinase D1	Homo sapiens	23-26
16935250-3	2006	On the peptide array, the relative cell-adhesion ratio of NIH/3T3 cells was 2.5-fold higher on the RGDS (Arg-Gly-Asp-Ser) peptide spot as compared to the spot with no peptide, thus indicating integrin-mediated peptide-cell interaction.	Arginine	105-108	ral guanine nucleotide dissociation stimulator	Mus musculus	99-103
16670299-8	2006	In conclusion, the increased arginine transport mediated by activators is strongly regulated by CAT2 expression, which could limit the function of macrophages.	Arginine	29-37	dominant cataract 2	Mus musculus	96-100
16399878-6	2006	Induction of necrotizing pancreatitis by treatment with L-arginine caused a 12-fold increase in the number of spinal neurons expressing the proto-oncogene c-fos in laminae I and II of L1, suggesting activation of nociceptive pathways.	Arginine	56-66	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	140-160
16399878-6	2006	Induction of necrotizing pancreatitis by treatment with L-arginine caused a 12-fold increase in the number of spinal neurons expressing the proto-oncogene c-fos in laminae I and II of L1, suggesting activation of nociceptive pathways.	Arginine	56-66	ribosomal protein L4	Rattus norvegicus	172-186
16332725-4	2006	The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively.	Arginine	171-174	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-8
16332725-4	2006	The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively.	Arginine	171-174	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-8
16332725-6	2006	Individuals having ALDH2 Glu/Glu with ADH2 Arg+, ALDH2 Lys+ with ADH2 His/His and ALDH2 Lys+ with ADH2 Arg+ showed ORs of 0.10(0.04-0.21), 0.10 (0.06-0.19) and 1.36 (0.94-1.97), respectively, compared with ALDH2 Glu/Glu with ADH2 His/His.	Arginine	43-46	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	38-42
16672841-1	2006	INTRODUCTION: Several common polymorphisms of the beta2 adrenergic (ADRB2) have been described including a Glycine (Gly) for arginine (Arg) substitution at amino acid 16.	Arginine	125-133	adrenoceptor beta 2	Homo sapiens	68-73
16672841-1	2006	INTRODUCTION: Several common polymorphisms of the beta2 adrenergic (ADRB2) have been described including a Glycine (Gly) for arginine (Arg) substitution at amino acid 16.	Arginine	135-138	adrenoceptor beta 2	Homo sapiens	68-73
16315320-4	2006	Intracellular cathepsin B activity detected by degradation of Z-Arg-Arg cresyl violet substrate was co-localized with the products of DQ-collagen IV degradation in the perinuclear region and in the capillary-like tubular structures.	Arginine	64-67	cathepsin B	Homo sapiens	14-25
16545809-3	2006	This difference could be explained by the regulation of a key enzyme of the arginine biosynthesis pathway, N-acetyl glutamate kinase (NAGK) by PII.	Arginine	76-84	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	107-132
16545809-3	2006	This difference could be explained by the regulation of a key enzyme of the arginine biosynthesis pathway, N-acetyl glutamate kinase (NAGK) by PII.	Arginine	76-84	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	134-138
30504773-8	2018	PRMT1 interacts with and methylates CaMKII at arginine residues 9 and 275, leading to its inhibition.	Arginine	46-54	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	36-42
30082494-4	2018	PRMT5 contributes to GC formation and affinity maturation at least in part through its direct interaction with and methylation of BCL6 at arginine 305 (R305), a modification necessary for the full transcriptional repressive effects of BCL6.	Arginine	138-146	BCL6 transcription repressor	Homo sapiens	130-134
16504488-1	2006	Mice with targeted deletion of the GABA-degradative enzyme succinate semialdehyde dehydrogenase (SSADH; Aldh5a1; OMIM 271,980) manifest globally elevated GABA and regionally decreased arginine in brain extracts.	Arginine	184-192	aldehyde dehydrogenase 5 family member A1	Homo sapiens	59-95
16504488-1	2006	Mice with targeted deletion of the GABA-degradative enzyme succinate semialdehyde dehydrogenase (SSADH; Aldh5a1; OMIM 271,980) manifest globally elevated GABA and regionally decreased arginine in brain extracts.	Arginine	184-192	aldehyde dehydrogenase 5 family member A1	Homo sapiens	97-102
16504488-1	2006	Mice with targeted deletion of the GABA-degradative enzyme succinate semialdehyde dehydrogenase (SSADH; Aldh5a1; OMIM 271,980) manifest globally elevated GABA and regionally decreased arginine in brain extracts.	Arginine	184-192	aldehyde dehydrogenase 5 family member A1	Homo sapiens	104-111
30082494-4	2018	PRMT5 contributes to GC formation and affinity maturation at least in part through its direct interaction with and methylation of BCL6 at arginine 305 (R305), a modification necessary for the full transcriptional repressive effects of BCL6.	Arginine	138-146	BCL6 transcription repressor	Homo sapiens	235-239
30056252-12	2018	In conclusion spironolactone and eplerenone augment arginine transport and NO generation through modulation of CAT-1 in endothelial cells.	Arginine	52-60	solute carrier family 7 member 1	Homo sapiens	111-116
16683069-2	2006	Normotensive adults homozygous for glycine (Gly) of the Arg16/Gly beta2-adrenergic receptor polymorphism have a greater forearm beta2-receptor mediated vasodilation and a higher cardiac output response to isometric handgrip than arginine (Arg) homozygotes.	Arginine	229-237	adrenoceptor beta 2	Homo sapiens	66-91
16683069-2	2006	Normotensive adults homozygous for glycine (Gly) of the Arg16/Gly beta2-adrenergic receptor polymorphism have a greater forearm beta2-receptor mediated vasodilation and a higher cardiac output response to isometric handgrip than arginine (Arg) homozygotes.	Arginine	56-59	adrenoceptor beta 2	Homo sapiens	66-91
30353119-3	2018	In this study, we shed light on the mechanism through which AdiC distinguishes Arg+ from Arg2+ of arginine by investigating the binding of both forms in addition to that of divalent agmatine, using a combination of molecular dynamics simulations with molecular and quantum mechanics calculations.	Arginine	98-106	arginase 2	Homo sapiens	89-93
16521120-3	2006	Based on the available NF2 mutation data, the most dominant influence on the spectra of mutations in exons 1-15 are C>T transitions that change arginine codons (CGA) to stop codons (TGA) due to spontaneous deamination of methylcytosine to thymine in CpG dinucleotides.	Arginine	144-152	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	23-26
16452487-0	2006	Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.	Arginine	163-171	usherin	Homo sapiens	67-70
16497987-4	2006	Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline.	Arginine	184-194	protocadherin 8	Homo sapiens	3-7
16322642-1	2006	RATIONALE: Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists.	Arginine	84-92	adrenoceptor beta 2	Homo sapiens	121-146
16508003-2	2006	Here, we show a novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover of p21cip1/waf1 mRNA in PC12 cells.	Arginine	35-43	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	66-117
16508003-2	2006	Here, we show a novel mechanism of arginine methylation of HuD by coactivator-associated arginine methyltransferase 1 (CARM1) that affected mRNA turnover of p21cip1/waf1 mRNA in PC12 cells.	Arginine	35-43	coactivator-associated arginine methyltransferase 1	Rattus norvegicus	119-124
16492753-1	2006	The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine.	Arginine	201-209	arginine permease CAN1	Saccharomyces cerevisiae S288C	120-124
16492753-1	2006	The fidelity of yeast RNA polymerase II (Pol II) was assessed in vivo with an assay in which errors in transcription of can1-100, a nonsense allele of CAN1, result in enhanced sensitivity to the toxic arginine analog canavanine.	Arginine	201-209	arginine permease CAN1	Saccharomyces cerevisiae S288C	151-155
16875604-6	2006	The XRCC1 194Trp allele carriers had higher response rate than the subjects with the Arg/Arg genotype (adjusted OR, 2.48; 95% CI, 1.36 - 4.51, P = 0.003).	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	4-9
16875604-6	2006	The XRCC1 194Trp allele carriers had higher response rate than the subjects with the Arg/Arg genotype (adjusted OR, 2.48; 95% CI, 1.36 - 4.51, P = 0.003).	Arginine	89-92	X-ray repair cross complementing 1	Homo sapiens	4-9
16352594-4	2006	Mutational analysis of the alpha1b-AR revealed that the binding site for ezrin involves a stretch of at least four arginines on the receptor C-tail.	Arginine	115-124	adrenoceptor alpha 1B	Homo sapiens	27-37
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Arginine	290-298	integrin subunit alpha M	Homo sapiens	24-29
16455964-4	2006	A significant number of CD11b(+)/Gr-1(+) cells expressing arginase 1 accumulated in T cell zones around the germinal centers of the white pulp of the spleen within 6 h of trauma and lasted for at least 72 h. Increased arginase activity and arginase 1 expression, along with increased [(3)H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were observed exclusively in CD11b(+)/Gr-1(+) cells after traumatic stress.	Arginine	307-317	integrin subunit alpha M	Homo sapiens	24-29
16455964-7	2006	The suppressive effects by trauma CD11b(+)/Gr-1(+) cells were overcome with the arginase antagonist N-hydroxy-nor-l-arginine or extrasupplementation of medium with l-arginine.	Arginine	114-124	integrin subunit alpha M	Homo sapiens	34-39
16455964-9	2006	This study demonstrates that CD11b(+)/Gr-1(+) cells invade the spleen following traumatic stress and cause T cell dysfunction by an arginase-mediated mechanism, probably that of arginine depletion.	Arginine	178-186	integrin subunit alpha M	Homo sapiens	29-34
16426244-0	2006	Association between ICAM-1 Gly-Arg polymorphism and renal parenchymal scarring following childhood urinary tract infection.	Arginine	31-34	intercellular adhesion molecule 1	Homo sapiens	20-26
16418218-8	2006	Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide.	Arginine	183-186	F11 receptor	Homo sapiens	41-46
16418218-8	2006	Immunoprecipitation analysis showed that JAM-A interacts with integrin alpha(v)beta(3), and this association was increased by engagement of the ligand-binding site of the integrin by Arg-Gly-Asp-Ser (RGDS) peptide.	Arginine	183-186	integrin subunit alpha V	Homo sapiens	62-85
16525354-14	2006	Higher myeloperoxidase activities were observed in the Arg groups at 24 h after CLP than those in the control group in various organs.	Arginine	55-58	myeloperoxidase	Mus musculus	7-22
16286457-7	2006	Overexpression of wild-type IkappaB-beta blocks LK-induced apoptosis, but this effect is abolished when Arg is pharmacologically inhibited.	Arginine	104-107	NFKB inhibitor beta	Homo sapiens	28-40
20641599-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	136-147
16357581-3	2006	RECENT FINDINGS: A genotype-stratified study revealed that greater bronchoprotective effect of anticholinergic agents was observed in asthmatic patients with the Arg/Arg genotype of the beta2-adrenergic receptor.	Arginine	162-165	adrenoceptor beta 2	Homo sapiens	186-211
16357581-3	2006	RECENT FINDINGS: A genotype-stratified study revealed that greater bronchoprotective effect of anticholinergic agents was observed in asthmatic patients with the Arg/Arg genotype of the beta2-adrenergic receptor.	Arginine	166-169	adrenoceptor beta 2	Homo sapiens	186-211
17168727-3	2006	Many enzymes display a preference for the arginine residue that is found in many natural substrates and in synthetic inhibitors of many trypsin-like serine proteases, e.g. thrombin, factor Xa, factor VIIa, trypsin, and in integrin receptor antagonists, used to treat many blood-coagulation disorders.	Arginine	42-50	coagulation factor X	Homo sapiens	182-191
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	40-48	coagulation factor X	Homo sapiens	171-180
17168727-9	2006	This review will describe the survey of arginine mimetics designed to mimic the function of the arginine moiety in numerous peptidomimetic compounds (thrombin inhibitors, factor Xa inhibitors, factor VIIa inhibitors, integrin receptor antagonists, nitric oxide synthase inhibitors), with the aim of obtaining better activity, selectivity and oral bioavailability.	Arginine	96-104	coagulation factor X	Homo sapiens	171-180
17219957-0	2006	Influence of L-arginine on the expression of eNOS and COX2 in experimental pulmonary thromboembolism.	Arginine	13-23	nitric oxide synthase 3	Rattus norvegicus	45-49
17219957-1	2006	The influence of L-arginine on endothelial nitric oxide synthase (eNOS) and cyclooxygenase 2 (COX2) was observed in experimental pulmonary thromboembolism and the action mechanism on pulmonary thromboembolism was explored.	Arginine	17-27	nitric oxide synthase 3	Rattus norvegicus	31-64
17219957-1	2006	The influence of L-arginine on endothelial nitric oxide synthase (eNOS) and cyclooxygenase 2 (COX2) was observed in experimental pulmonary thromboembolism and the action mechanism on pulmonary thromboembolism was explored.	Arginine	17-27	nitric oxide synthase 3	Rattus norvegicus	66-70
16408119-4	2006	Among several transporters that mediate L-arginine uptake, cationic amino-acid transporter-1 (CAT-1) acts as the specific arginine transporter for eNOS.	Arginine	40-50	nitric oxide synthase 3	Rattus norvegicus	147-151
16369119-1	2006	BACKGROUND: beta(2)-Adrenergic receptor (beta(2)-AR) polymorphisms occurring at amino acid position 16 (Arg-Gly) and 27 (Gln-Glu) are known to be functionally relevant and also disease-modifying in subjects with asthma.	Arginine	104-107	adrenoceptor beta 2	Homo sapiens	12-39
16369119-1	2006	BACKGROUND: beta(2)-Adrenergic receptor (beta(2)-AR) polymorphisms occurring at amino acid position 16 (Arg-Gly) and 27 (Gln-Glu) are known to be functionally relevant and also disease-modifying in subjects with asthma.	Arginine	104-107	adrenoceptor beta 2	Homo sapiens	41-51
16369120-1	2006	BACKGROUND: As a result of the finding that the mutation of Arg into Gly at beta(2)-adrenergic receptor (beta(2)-AR)16 loci could promote the downregulation effect triggered by the beta(2)-agonist, it was supposed that Gly16 might be associated with the downregulation of beta(2)-AR in patients with nocturnal asthma.	Arginine	60-63	adrenoceptor beta 2	Homo sapiens	105-115
16369120-1	2006	BACKGROUND: As a result of the finding that the mutation of Arg into Gly at beta(2)-adrenergic receptor (beta(2)-AR)16 loci could promote the downregulation effect triggered by the beta(2)-agonist, it was supposed that Gly16 might be associated with the downregulation of beta(2)-AR in patients with nocturnal asthma.	Arginine	60-63	adrenoceptor beta 2	Homo sapiens	272-282
16332834-0	2005	Twin-arginine translocation of active human tissue plasminogen activator in Escherichia coli.	Arginine	5-13	chromosome 20 open reading frame 181	Homo sapiens	44-72
16251196-3	2005	Lysosomes isolated from lymphoblast cell lines, established from individuals with juvenile Batten disease-bearing mutations in CLN3, but not age-matched controls, demonstrate defective transport of arginine.	Arginine	198-206	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	127-131
16251196-7	2005	These results suggest that the CLN3 defect in juvenile Batten disease may affect how intracellular levels of arginine are regulated or distributed throughout the cell.	Arginine	109-117	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	31-35
16251196-9	2005	First, an antibody to CLN3 can block lysosomal arginine transport and second, expression of CLN3 in JNCL cells using a lentiviral vector can restore lysosomal arginine transport.	Arginine	47-55	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	22-26
16251196-9	2005	First, an antibody to CLN3 can block lysosomal arginine transport and second, expression of CLN3 in JNCL cells using a lentiviral vector can restore lysosomal arginine transport.	Arginine	159-167	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	92-96
16251196-10	2005	CLN3 may have a role in regulating intracellular levels of arginine possibly through control of the transport of this amino acid into lysosomes.	Arginine	59-67	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	0-4
30349045-5	2018	p62 is essential for mTORC1 activation in response to arginine, but it is not a direct sensor of free arginine in the mTORC1 pathway.	Arginine	54-62	sequestosome 1	Homo sapiens	0-3
16254053-9	2005	Previous work has shown that CARM1 can methylate CBP at three arginine residues.	Arginine	62-70	coactivator associated arginine methyltransferase 1	Homo sapiens	29-34
30188967-4	2018	The amino acid mutation analysis identified Arg 120 and 437 as the proteolytic sites in Fam198a precursor during maturation.	Arginine	44-47	golgi associated kinase 1A	Mus musculus	88-95
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	67-75	coactivator associated arginine methyltransferase 1	Homo sapiens	52-57
16254053-10	2005	Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II.	Arginine	105-113	coactivator associated arginine methyltransferase 1	Homo sapiens	52-57
16465055-0	2005	The effects of L-arginine on neurological function, histopathology, and expression of hypoxia-inducible factor-1 alpha following spinal cord ischemia in rats.	Arginine	15-25	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	86-118
29807069-13	2018	l-Arginine lowered the brain oxidative stress, inflammation, AChE activity, eNOS expression (not activity), NFkappaB levels and elevated nitrite content.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	76-80
16465055-1	2005	The aim of this study was to investigate the effects of L-arginine (L-Arg) on neurological function, histopathology, and expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) following spinal cord ischemia in rats, and the interaction between therapy with the nitric oxide donor L-Arg and up-regulation of the expression of HIF-1alpha.	Arginine	56-66	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	135-167
16465055-1	2005	The aim of this study was to investigate the effects of L-arginine (L-Arg) on neurological function, histopathology, and expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) following spinal cord ischemia in rats, and the interaction between therapy with the nitric oxide donor L-Arg and up-regulation of the expression of HIF-1alpha.	Arginine	68-73	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	135-167
30152697-3	2018	The peptide sequence Arg-Gly-Asp (RGD), which is present in a number of endogenous integrin ligands like fibronectin, vitronectin, and related proteins of the extracellular matrix (ECM), has been extensively used as a targeting vector for therapeutic as well as diagnostic purposes, and cilengitide, a cyclic RGD peptide, has entered clinical trials for the treatment of various cancers.	Arginine	21-24	vitronectin	Homo sapiens	118-129
16465055-1	2005	The aim of this study was to investigate the effects of L-arginine (L-Arg) on neurological function, histopathology, and expression of hypoxia-inducible factor-1 alpha (HIF-1alpha) following spinal cord ischemia in rats, and the interaction between therapy with the nitric oxide donor L-Arg and up-regulation of the expression of HIF-1alpha.	Arginine	285-290	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	169-179
16465055-12	2005	In conclusion, our findings suggest that HIF-1alpha-positive immunostaining may be critical factors in the pathophysiology of inflammatory spinal cord injury induced by I-R. Nitric oxide may play an important role in the immunohistochemical expression of these molecules, and the neuroprotective benefit of L-Arg may be attributed to preventing neural cell necrosis.	Arginine	307-312	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	41-51
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	E1A binding protein p300	Mus musculus	97-101
29602958-8	2018	HDLM-2 derived HLA-G peptides are anchored by an Arg at p1 and K562-derived peptides are anchored by a Lys.	Arginine	49-52	major histocompatibility complex, class I, G	Homo sapiens	15-20
16096342-7	2005	The S4 segment of Kv6.3 could act as a voltage sensor in the Kv2.1 context, albeit with a major hyperpolarizing shift in the voltage dependence of activation and inactivation, apparently caused by the presence of a tyrosine in Kv6.3 instead of a conserved arginine.	Arginine	256-264	potassium voltage-gated channel modifier subfamily G member 3	Homo sapiens	18-23
16096342-7	2005	The S4 segment of Kv6.3 could act as a voltage sensor in the Kv2.1 context, albeit with a major hyperpolarizing shift in the voltage dependence of activation and inactivation, apparently caused by the presence of a tyrosine in Kv6.3 instead of a conserved arginine.	Arginine	256-264	potassium voltage-gated channel modifier subfamily G member 3	Homo sapiens	227-232
29746817-0	2018	Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo.	Arginine	0-8	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	97-101
16242037-5	2005	RESULTS: Using a combination of peptide library selection, phosphorylation of optimal peptide variants, and screening of a phosphosite array, we found that Dbf2-Mob1 preferentially phosphorylated serine over threonine and required an arginine three residues upstream of the phosphorylated serine in its substrate.	Arginine	234-242	MOB kinase activator 1A	Homo sapiens	161-165
29746817-0	2018	Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-kappaB-GCN2/eIF2alpha signaling pathway in mammary epithelial cells in vitro and in vivo.	Arginine	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	102-111
29746817-3	2018	Our previous study demonstrated that diet-derived IFN-gamma promoted the malignant transformation of primary bovine mammary epithelial cells by accelerating arginine depletion.	Arginine	157-165	interferon gamma	Bos taurus	50-59
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	interleukin 17A	Mus musculus	178-183
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	interleukin 17A	Mus musculus	222-227
20641210-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	130-141
29784880-4	2018	Herein, using various biochemical assays, we confirmed the earlier observations that TLS is methylated by protein arginine methyltransferase 1 (PRMT1) in vitro The arginine methylation of TLS disrupted binding to pncRNA and also prevented binding of TLS to and inhibition of CBP/p300.	Arginine	114-122	protein arginine methyltransferase 1	Homo sapiens	144-149
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	100-108	BRCA1 DNA repair associated	Homo sapiens	42-47
29951983-7	2018	Response with L-arginine was increased in Burn group, but decreased in PRP group.	Arginine	14-24	proline rich protein 2-like 1	Rattus norvegicus	71-74
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	100-108	mediator of DNA damage checkpoint 1	Homo sapiens	121-125
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	127-130	BRCA1 DNA repair associated	Homo sapiens	42-47
16049003-4	2005	By a comparison with the structure of the BRCA1 BRCT bound to a phosphopeptide, we suggest that two arginine residues in MDC1, Arg(1932) and Arg(1933) may recognize the COOH terminus of the peptide as well as the penultimate Glu of H2AX, while Gln(2013) may provide additional specificity for the COOH-terminal Tyr.	Arginine	141-144	BRCA1 DNA repair associated	Homo sapiens	42-47
29665354-0	2018	PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH.	Arginine	75-83	protein arginine methyltransferase 1	Homo sapiens	0-5
15998640-5	2005	The MTMR13 phosphatase domain is catalytically inactive because the essential Cys and Arg residues are absent.	Arginine	86-89	SET binding factor 2	Homo sapiens	4-10
16159817-11	2005	Addition of L-arginine improved myocardial perfusion in response to FGF-2 at rest (ratio 1.13, P=0.02 versus HICHOL) but not during pacing (ratio 0.94, P=NS), and was associated with increased protein levels of iNOS and eNOS.	Arginine	12-22	fibroblast growth factor 2	Sus scrofa	68-73
16159817-12	2005	CONCLUSIONS: L-arginine supplementation can partially restore the normal response to endothelium-dependent vasorelaxants and myocardial perfusion in response to FGF-2 treatment in a swine model of hypercholesterolemia-induced endothelial dysfunction.	Arginine	13-23	fibroblast growth factor 2	Sus scrofa	161-166
29665354-4	2018	Here, we found that protein arginine methyltransferase 1 (PRMT1) mediated arginine methylation of GAPDH in primary bone marrow-derived macrophages in a NO-dependent manner.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	58-63
29665354-7	2018	Taken together, our results suggest that PRMT1 has a previously unrecognized function to inhibit activation-induced cell death of macrophages through arginine methylation of GAPDH.	Arginine	150-158	protein arginine methyltransferase 1	Homo sapiens	41-46
29920217-8	2018	Together, these findings reveal a novel regulatory mechanism of DUSP14 by which PRMT5-mediated arginine methylation may sequentially stimulate TRAF2-mediated DUSP14 ubiquitination and phosphatase activity, leading to inhibition of TCR signaling.-Yang, C.-Y., Chiu, L.-L., Chang, C.-C., Chuang, H.-C., Tan, T.-H.	Arginine	95-103	TNF receptor associated factor 2	Homo sapiens	143-148
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Arginine	129-132	coagulation factor X	Homo sapiens	58-61
29895960-2	2018	Mutation in RBM20 is linked to autosomal-dominant familial dilated cardiomyopathy (DCM), yet most of the RBM20 missense mutations in familial and sporadic cases were mapped to an RSRSP stretch in an arginine/serine-rich region of which function remains unknown.	Arginine	199-207	RNA binding motif protein 20	Homo sapiens	12-17
15987731-1	2005	A number of studies have investigated two common polymorphisms in the beta(2)-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility.	Arginine	97-100	adrenoceptor beta 2	Homo sapiens	70-90
29895960-2	2018	Mutation in RBM20 is linked to autosomal-dominant familial dilated cardiomyopathy (DCM), yet most of the RBM20 missense mutations in familial and sporadic cases were mapped to an RSRSP stretch in an arginine/serine-rich region of which function remains unknown.	Arginine	199-207	RNA binding motif protein 20	Homo sapiens	105-110
29486359-6	2018	The results showed that the terrestrial ARGs influenced the concentration of the corresponding ARGs in coastal areas, and the content change pattern of each ARG was distinct.	Arginine	40-43	serpin family A member 2 (gene/pseudogene)	Homo sapiens	95-99
16012750-6	2005	In our recent study, not only leucine, but also arginine is shown to activate the mTOR signaling pathway in rat intestinal epithelial cells.	Arginine	48-56	mechanistic target of rapamycin kinase	Rattus norvegicus	82-86
16012750-7	2005	Furthermore, regarding L-Glutamine, an important amino acid that is required for culturing of numerous cell types, including rat intestinal epithelial cells, we have shown that it had an inhibitory effect on leucine- or arginine-induced activation of the mTOR signaling pathway.	Arginine	220-228	mechanistic target of rapamycin kinase	Rattus norvegicus	255-259
16012769-3	2005	Mutation of 138 arginine residue of Zn2+ finger 2 had negligible influence on the inhibitory action of ATP, pinpointing arginine 34 of the first Zn2+ finger as the specific ATP site.	Arginine	16-24	Yip1 domain family member 2	Homo sapiens	41-49
16012769-3	2005	Mutation of 138 arginine residue of Zn2+ finger 2 had negligible influence on the inhibitory action of ATP, pinpointing arginine 34 of the first Zn2+ finger as the specific ATP site.	Arginine	120-128	Yip1 domain family member 2	Homo sapiens	41-49
29645362-1	2018	As a reader of di-methylated arginine on various proteins, such as histone, RNA polymerase II, PIWI and Fragile X mental retardation protein, the Tudor domain of Tudor domain-containing protein 3 (TDRD3) mediates transcriptional activation in nucleus and formation of stress granules in the cytoplasm.	Arginine	29-37	piwi like RNA-mediated gene silencing 1	Homo sapiens	95-99
29843741-12	2018	Crystal structural analysis further indicated that the substitution from arginine to tryptophan at the highly conserved residue 419 of TULP1 could lead to the elimination of two hydrogen bonds between residue 419 and residues V488 and S534.	Arginine	73-81	TUB like protein 1	Homo sapiens	135-140
16122935-7	2005	Previous biochemical studies have indicated that allosteric regulation of the first and, especially, the second steps in Orn synthesis (NAGS; N-acetylglutamate kinase (NAGK), EC 2.7.2.8) by the Arg end-product are the major sites of metabolic control of the pathway in organisms using the cyclic pathway.	Arginine	194-197	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	142-166
16122935-7	2005	Previous biochemical studies have indicated that allosteric regulation of the first and, especially, the second steps in Orn synthesis (NAGS; N-acetylglutamate kinase (NAGK), EC 2.7.2.8) by the Arg end-product are the major sites of metabolic control of the pathway in organisms using the cyclic pathway.	Arginine	194-197	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	168-172
16122935-8	2005	Gene expression profiling for pathway enzymes further suggests that NAGS, NAGK, NAOGAcT and NAOD are coordinately regulated in response to changes in Arg demand during plant growth and development.	Arginine	150-153	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	74-78
29330883-1	2018	Heterozygous variants in the arginine-glutamic acid dipeptide repeats gene (RERE) have been shown to cause neurodevelopmental disorder with or without anomalies of the brain, eye, or heart (NEDBEH).	Arginine	29-37	arginine-glutamic acid dipeptide repeats	Homo sapiens	76-80
15920735-2	2005	OPN contains the arginine-glycine-aspartic acid (RGD) moiety that has been shown to mediate cell adhesion through interactions with integrins.	Arginine	17-25	secreted phosphoprotein 1	Bos taurus	0-3
15830218-4	2005	The ERR triad is a glutamine-arginine-arginine motif conserved in all cytochrome P450 sequences.	Arginine	29-37	solute carrier family 7 member 1	Homo sapiens	4-7
15830218-4	2005	The ERR triad is a glutamine-arginine-arginine motif conserved in all cytochrome P450 sequences.	Arginine	38-46	solute carrier family 7 member 1	Homo sapiens	4-7
15952780-2	2005	Two mutants were created to determine the mechanistic reason for the CRP biphasic response by inhibiting binding of cAMP to the secondary site via interference with the Arg 181 interaction with the ligand"s phosphate.	Arginine	169-172	catabolite gene activator protein	Escherichia coli	69-72
15938644-8	2005	A number of substitutions in the YFF peptide outlined the importance of Ile and Arg at positions n - 1 and n + 6 in addition to the central triplet, to ensure efficient phosphorylation by ALK.	Arginine	80-83	ALK receptor tyrosine kinase	Homo sapiens	188-191
15826948-0	2005	Are STATS arginine-methylated?	Arginine	10-18	signal transducer and activator of transcription 1	Homo sapiens	4-9
15826948-3	2005	Recent evidence suggested that STATs are methylated on a conserved arginine residue within the N-terminal region.	Arginine	67-75	signal transducer and activator of transcription 1	Homo sapiens	31-36
15899857-8	2005	We also discovered enhancement of the ER-stressed induction of the Grp78 promoter through the interaction of YY1 with the arginine methyltransferase PRMT1 and evidence of its action through methylation of the arginine 3 residue on histone H4.	Arginine	122-130	protein arginine methyltransferase 1	Homo sapiens	149-154
15929998-7	2005	We also found that the replacement of residues Arg(301) and Arg(304), localized near the steroid-binding cavity, significantly affects the 3alpha-HSD activity of this enzyme toward 5alpha-DHT and completely abolishes its 17beta-HSD activity on 4-dione.	Arginine	47-50	aldo-keto reductase family 1 member C4	Homo sapiens	139-149
15929998-7	2005	We also found that the replacement of residues Arg(301) and Arg(304), localized near the steroid-binding cavity, significantly affects the 3alpha-HSD activity of this enzyme toward 5alpha-DHT and completely abolishes its 17beta-HSD activity on 4-dione.	Arginine	60-63	aldo-keto reductase family 1 member C4	Homo sapiens	139-149
15617517-2	2005	In contrast with human TFPI, Ixolaris binds tightly to the zymogen FX (Factor X) and to dansyl-Glu-Gly-Arg-chloromethyl ketone-treated FXa (DEGR-FXa; active-site-blocked FXa), indicating that exosites are involved in the FX(a)-Ixolaris interaction.	Arginine	103-106	coagulation factor X	Homo sapiens	135-138
15617517-2	2005	In contrast with human TFPI, Ixolaris binds tightly to the zymogen FX (Factor X) and to dansyl-Glu-Gly-Arg-chloromethyl ketone-treated FXa (DEGR-FXa; active-site-blocked FXa), indicating that exosites are involved in the FX(a)-Ixolaris interaction.	Arginine	103-106	coagulation factor X	Homo sapiens	140-148
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Arginine	201-204	coagulation factor X	Homo sapiens	33-36
15898744-6	2005	The FP assay was successfully applied to measure the binding affinity to integrin alpha(v)beta(3) of several cyclic peptides containing the Arg-Gly-Asp (RGD) motif.	Arginine	140-143	integrin subunit alpha V	Homo sapiens	73-97
15811383-7	2005	This interaction appears to be mediated by the proline-arginine-rich domain (PRD) of Dyn2, as a GST-PRD fragment binds Cav1 while GST-Dyn2DeltaPRD does not.	Arginine	55-63	dynamin 2	Homo sapiens	85-89
15823024-8	2005	However, model reactions involving the single amino acids lysine, arginine, and tyrosine, residues known to be involved in base contacts in the DNA:SSB complex, could be studied, and the adduct formed between N(alpha)-acetyllysine methyl ester and an 18-mer containing OG was tentatively characterized by electrospray ionization mass spectrometry as analogues of spiroiminodihydantoin and guanidinohydantoin.	Arginine	66-74	single-stranded DNA-binding protein	Escherichia coli	148-151
29063269-7	2018	CONCLUSIONS: The ADH1B Arg/Arg genotype and the ALDH2 Glu/Lys genotype were positive determinants of fatty liver in the subjects.	Arginine	23-26	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	17-22
29063269-7	2018	CONCLUSIONS: The ADH1B Arg/Arg genotype and the ALDH2 Glu/Lys genotype were positive determinants of fatty liver in the subjects.	Arginine	27-30	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	17-22
29407646-6	2018	Nearly 90% ARG subtypes in the anaerobic digestion sludge from sewage treatment plants (STPADS) were shared by the leachate and the abundances of leachate and STPADS ARGs generalists accounted for 84.5% and 87.7% of total abundances in these two types of anaerobic samples, respectively.	Arginine	11-14	serpin family A member 2 (gene/pseudogene)	Homo sapiens	166-170
29162499-4	2018	Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP).	Arginine	45-55	antizyme inhibitor 2	Rattus norvegicus	83-105
29558951-5	2018	HM-3, an antitumor peptide including an Arg-Gly-Asp sequence, can specifically target integrin alphavbeta3 that is presented on some tumor cells.	Arginine	40-43	integrin subunit alpha V	Homo sapiens	86-106
29721066-10	2018	Results: In vitro studies revealed that in response to ADI-PEG20 treatment, arginine auxotrophs increase the uptake of L-[3H]arginine and [18F]AFETP due to an increase in the expression and localization to the plasma membrane of the cationic amino acid transporter CAT-1.	Arginine	76-84	solute carrier family 7 member 1	Homo sapiens	265-270
29721066-12	2018	Conclusion: CAT-1 transporters localizes to the plasma membrane as a result of arginine starvation with ADI-PEG20 in ASS1-deficient tumor cells and provides a mechanism for using cationic amino acid transport substrates such as [18F]AFETP for identifying tumors susceptible to ADI-PEG20 treatment though non-invasive PET imaging techniques.	Arginine	79-87	solute carrier family 7 member 1	Homo sapiens	12-17
29193371-3	2018	Gly-Arg-Rich regions (RGG-boxes) within FET proteins are targets for methylation by Protein-Arginine-Methyl-Transferase-1 (PRMT1) and substrate capture is thought to involve electrostatic attraction between positively charged polyRGG substrates and negatively charged surface channels of PRMT1.	Arginine	4-7	protein arginine methyltransferase 1	Homo sapiens	84-121
29193371-3	2018	Gly-Arg-Rich regions (RGG-boxes) within FET proteins are targets for methylation by Protein-Arginine-Methyl-Transferase-1 (PRMT1) and substrate capture is thought to involve electrostatic attraction between positively charged polyRGG substrates and negatively charged surface channels of PRMT1.	Arginine	4-7	protein arginine methyltransferase 1	Homo sapiens	123-128
29193371-3	2018	Gly-Arg-Rich regions (RGG-boxes) within FET proteins are targets for methylation by Protein-Arginine-Methyl-Transferase-1 (PRMT1) and substrate capture is thought to involve electrostatic attraction between positively charged polyRGG substrates and negatively charged surface channels of PRMT1.	Arginine	4-7	protein arginine methyltransferase 1	Homo sapiens	288-293
29432156-9	2018	Mutation of lysine residues to arginines in the N-terminal region of BubR1 partially inhibited its ubiquitylation and slowed down the release of MCC from APC/C, provided that Cdc20 ubiquitylation was also blocked.	Arginine	31-40	cell division cycle 20	Homo sapiens	175-180
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	55-58	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	60-63
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	55-58	cathepsin B	Homo sapiens	95-106
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	47-50
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	60-63
29463776-6	2018	We found that the nonreceptor tyrosine kinases Abl and Arg (Abl/Arg) promoted the secretion of cathepsin B and cathepsin L by activating transcription factors (namely, Ets1, Sp1, and NF-kappaB/p65) that have key roles in the epithelial-mesenchymal transition (EMT), invasion, and therapeutic resistance.	Arginine	64-67	cathepsin B	Homo sapiens	95-106
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	cathepsin B	Homo sapiens	80-91
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	33-36	cathepsin B	Homo sapiens	307-318
29463776-7	2018	In some melanoma cell lines, Abl/Arg promoted the Ets1/p65-induced secretion of cathepsin B and cathepsin L in a kinase-independent manner, whereas in other melanoma lines, Abl/Arg promoted the kinase-dependent, Sp1/Ets1/p65-mediated induction of cathepsin L secretion and the Sp1/p65-mediated induction of cathepsin B secretion.	Arginine	177-180	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	29-32
29463776-8	2018	As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion.	Arginine	76-79	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	72-75
29463776-8	2018	As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion.	Arginine	163-166	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	72-75
15805427-1	2005	Microdissected rat proximal straight tubules (PST) and inner medullary collecting ducts (IMCD) highly produce urea from l-arginine, supporting the expression of the mitochondrial arginase II.	Arginine	120-130	arginase 2	Rattus norvegicus	179-190
29434212-1	2018	CARM1 is an arginine methyltransferase that asymmetrically dimethylates protein substrates on arginine residues.	Arginine	12-20	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
29208698-0	2018	Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity.	Arginine	0-8	lecithin-cholesterol acyltransferase	Homo sapiens	52-88
15798186-3	2005	This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa).	Arginine	32-40	arginine/serine-rich coiled-coil 1	Mus musculus	80-86
15798186-3	2005	This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa).	Arginine	32-40	arginine/serine-rich coiled-coil 1	Mus musculus	92-120
29976090-8	2018	By forming a complex with PARK7 (and possibly misfolded protein cargoes), R-HSPA5 binds SQSTM1 through its Nt-Arg, facilitating self-polymerization of SQSTM1 and the targeting of SQSTM1-cargo complexes to phagophores.	Arginine	110-113	sequestosome 1	Homo sapiens	88-94
15932671-9	2005	The aortic c-myc and c-fos expressions in both heme group and L-arg group reduced markedly compared with those in chol group, while they were similar to those in ZnPP and L-NAME group.	Arginine	62-67	myc proto-oncogene protein	Oryctolagus cuniculus	11-16
28557341-3	2018	An arginine to lysine mutant at amino acid site 358 could lead to the da1-1 phenotype, which results in an increased organ size and larger seeds.	Arginine	3-11	DA1	Arabidopsis thaliana	70-73
29077951-9	2018	Further, IOF of Arg increased the phosphoenolpyruvate carboxykinase (PEPCK) and fructose-1,6-bisphosphatase (FBP) mRNA expressions at hatch (P &lt; 0.05).	Arginine	16-19	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	34-67
15632185-2	2005	How the bound cofactor (6R)-tetrahydrobiopterin (H4B) participates in Arg hydroxylation is a topic of interest.	Arginine	70-73	H4 clustered histone 4	Homo sapiens	49-52
15632185-3	2005	We demonstrated previously that H4B radical formation in the inducible NOS oxygenase domain (iNOSoxy) is kinetically coupled to the disappearance of a heme-dioxy intermediate and to Arg hydroxylation.	Arginine	182-185	H4 clustered histone 4	Homo sapiens	32-35
29077951-9	2018	Further, IOF of Arg increased the phosphoenolpyruvate carboxykinase (PEPCK) and fructose-1,6-bisphosphatase (FBP) mRNA expressions at hatch (P &lt; 0.05).	Arginine	16-19	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	69-74
29077951-9	2018	Further, IOF of Arg increased the phosphoenolpyruvate carboxykinase (PEPCK) and fructose-1,6-bisphosphatase (FBP) mRNA expressions at hatch (P &lt; 0.05).	Arginine	16-19	fructose-bisphosphatase 1	Homo sapiens	80-107
29077951-9	2018	Further, IOF of Arg increased the phosphoenolpyruvate carboxykinase (PEPCK) and fructose-1,6-bisphosphatase (FBP) mRNA expressions at hatch (P &lt; 0.05).	Arginine	16-19	fructose-bisphosphatase 1	Homo sapiens	109-112
29683372-1	2018	Chtop binds competitively to the arginine methyltransferases PRMT1 and PRMT5, thereby promoting the asymmetric or symmetric methylation of arginine residues, respectively.	Arginine	33-41	protein arginine methyltransferase 1	Homo sapiens	61-66
15767338-10	2005	However, low antioxidant intake was associated with an inverse association only among subjects with the XRCC1 codon 194 Arg/Trp or Trp/Trp and codon 399 Arg/Arg or Arg/Gln combined genotypes (P for interaction = 0.022), which was independent of unsaturated fat intake.	Arginine	120-123	X-ray repair cross complementing 1	Homo sapiens	104-109
28921679-1	2018	Neuronal nitric oxide synthase (nNOS) is a key arginine metabolising enzyme in the brain, and nNOS-derived nitric oxide (NO) plays an important role in regulating glutamatergic neurotransmission.	Arginine	47-55	nitric oxide synthase 1	Rattus norvegicus	0-30
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Arginine	210-213	opioid receptor-like 1	Mus musculus	34-62
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Arginine	210-213	prepronociceptin	Mus musculus	98-103
15750346-1	2005	The role of residue C323 in catalysis by human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) was examined by substituting Arg, Gly, Leu, Met, or Tyr at C323 by cassette mutagenesis using synthetic human GDH isozyme genes.	Arginine	127-130	glutamate dehydrogenase 2	Homo sapiens	91-96
28921679-1	2018	Neuronal nitric oxide synthase (nNOS) is a key arginine metabolising enzyme in the brain, and nNOS-derived nitric oxide (NO) plays an important role in regulating glutamatergic neurotransmission.	Arginine	47-55	nitric oxide synthase 1	Rattus norvegicus	32-36
29061846-2	2017	SPIN1 harbors three Tudor domains, two of which engage the tail of histone H3 by reading the H3-Lys-4 trimethylation and H3-Arg-8 asymmetric dimethylation marks.	Arginine	124-127	spindlin 1	Homo sapiens	0-5
15605275-5	2005	However, the amino acid substitution was proline for arginine (R162P) in the 1A rod domain, the highly conserved helix initiation motif of keratin 9.	Arginine	53-61	keratin 9	Homo sapiens	139-148
29321782-2	2017	In a patient, initially diagnosed with chronic glomerulonephritis, possibly C3G, and who 6 years later had an episode of aHUS, a heterozygous missense mutation leading to a tryptophan to arginine exchange (W198R) in the factor H (FH) complement control protein (CCP) 3 domain has previously been identified.	Arginine	187-195	Rap guanine nucleotide exchange factor 1	Homo sapiens	76-79
15539552-11	2005	Consequently, in kidneys of testosterone-treated mice, L-arginine-derived ornithine produced by arginase II might be preferentially used by ODC for putrescine production rather than by OAT.	Arginine	55-65	ornithine decarboxylase, structural 1	Mus musculus	140-143
29321782-2	2017	In a patient, initially diagnosed with chronic glomerulonephritis, possibly C3G, and who 6 years later had an episode of aHUS, a heterozygous missense mutation leading to a tryptophan to arginine exchange (W198R) in the factor H (FH) complement control protein (CCP) 3 domain has previously been identified.	Arginine	187-195	complement factor H	Homo sapiens	220-228
15749837-5	2005	The bond between the tandem arginine residues in the sixth domain of factor H was cleaved.	Arginine	28-36	complement factor H	Homo sapiens	69-77
28299479-6	2017	We found that dietary Gln or Arg supplementation decreased bacterial colonization and promoted the activation of innate immunity (e.g., the mRNA expression of pIgR, CRS1C, and Reg3gamma) in the intestine of ETEC-infected mice.	Arginine	29-32	defensin, alpha, 29	Mus musculus	165-170
15659545-0	2005	The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton.	Arginine	8-11	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-7
29096248-3	2017	We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients that appeared to control the EMT (epithelial-mesenchymal transition) of cancer cells, in a process associated with miR-199a-3p.	Arginine	25-28	microRNA 199a-2	Homo sapiens	257-268
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	69-72	proline rich protein HaeIII subfamily 1	Homo sapiens	97-101
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	69-72	pre-mRNA processing factor 3	Homo sapiens	163-168
29225432-10	2017	The active site amino acids such as TYR-21, ASN-34, VAL-35, MET-18, LYS-17, SER-36, ARG- 46 and ARG-14 are key role in the inhibitors activity.	Arginine	84-87	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	60-66
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	69-72	pre-mRNA processing factor 4B	Homo sapiens	170-175
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	86-89	proline rich protein HaeIII subfamily 1	Homo sapiens	97-101
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	86-89	pre-mRNA processing factor 3	Homo sapiens	163-168
15693058-3	2005	Apart from Pa, all the other aPRPs undergo a proteolytic cleavage at Arg-106 residue (Arg-127 in Db-s protein), that generates the small PC peptide (4371 amu) and PRP-3, PRP-4, PIF-f (11,162 amu) and Db-f (13,280 amu) proteins, all of which were detected.	Arginine	86-89	pre-mRNA processing factor 4B	Homo sapiens	170-175
29225432-10	2017	The active site amino acids such as TYR-21, ASN-34, VAL-35, MET-18, LYS-17, SER-36, ARG- 46 and ARG-14 are key role in the inhibitors activity.	Arginine	96-99	MMS19 homolog, cytosolic iron-sulfur assembly component	Homo sapiens	60-66
28972166-6	2017	Our findings reveal that JMJD6 is a novel SG component that interacts with G3BP1 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Arg residues.	Arginine	179-182	G3BP stress granule assembly factor 1	Homo sapiens	75-80
29095251-1	2017	To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy.The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade &gt;=2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182-4.582).	Arginine	477-480	X-ray repair cross complementing 1	Homo sapiens	34-73
21166162-8	2005	The increased protein content and the decreased expression of PTEN protein were inhibited by L-Arg.	Arginine	93-98	phosphatase and tensin homolog	Rattus norvegicus	62-66
21166162-12	2005	The effect of L-arginine on cardiomyocytes may be mediated by NOS/NO and PTEN.	Arginine	14-24	phosphatase and tensin homolog	Rattus norvegicus	73-77
29095251-1	2017	To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy.The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade &gt;=2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182-4.582).	Arginine	477-480	X-ray repair cross complementing 1	Homo sapiens	75-80
29095251-1	2017	To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy.The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade &gt;=2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182-4.582).	Arginine	481-484	X-ray repair cross complementing 1	Homo sapiens	34-73
29095251-1	2017	To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT).Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy.The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade &gt;=2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182-4.582).	Arginine	481-484	X-ray repair cross complementing 1	Homo sapiens	75-80
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Arginine	160-168	Fc gamma receptor IIIa	Homo sapiens	28-40
28612866-3	2017	Herein, we describe conjugates comprising a pyrazolyl-diamine chelating unit and the cationic amino acid l-arginine (l-Arg) linked by a propyl (L1) or hexyl linker (L2), which allowed the preparation of stable complexes of the type fac-[99mTc(CO)3(k3-L)]+ (Tc1, L = L1; Tc2, L = L2) and of the respective surrogates Re1 and Re2.	Arginine	117-122	G protein-coupled receptor 161	Homo sapiens	324-327
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Arginine	160-168	Fc gamma receptor IIIa	Homo sapiens	48-60
15659493-5	2005	Two were commonly observed (FcgammaRIIIA-48 and FcgammaRIIIA-158) and predicted for amino acid polymorphisms at FcgammaRIIIA-48: leucine/leucine (L/L), leucine/arginine (L/R), and leucine/histidine (L/H).	Arginine	160-168	Fc gamma receptor IIIa	Homo sapiens	48-60
28842250-4	2017	RAP80 directly binds the internal region of p32 through its arginine rich C-terminal domain.	Arginine	60-68	ubiquitin interaction motif containing 1	Homo sapiens	0-5
15567168-2	2005	In our recent study, l-arginine was also shown to activate the mTOR signaling pathway in rat intestinal epithelial cells.	Arginine	21-31	mechanistic target of rapamycin kinase	Rattus norvegicus	63-67
15642139-8	2005	Using immobilized peptides, we confirmed that the dimethylated arginine residues play an essential role in the formation of major SmD1 and SmD3 autoepitopes.	Arginine	63-71	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	130-134
28864774-9	2017	We also found a more modest contribution from the positively charged Arg-1119 in the extracellular pore region in repeat III of CaV1.2.	Arginine	69-72	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	128-134
15663510-8	2005	DNA sequencing in all the affected individuals disclosed a heterozygous G--&gt;C substitution at nucleotide 173 of the fumarate hydratase gene, that converts an arginine residue (CGA) to proline (CCA).	Arginine	161-169	fumarate hydratase	Homo sapiens	119-137
29053970-4	2017	SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins.	Arginine	38-46	solute carrier family 38 member 9	Homo sapiens	0-7
16164021-3	2005	In order to globally characterize the role of arginine methylation in signal integration and developmental processes we decided to map genomic loci marked by protein arginine methyl transferase 1 (PRMT1) via histone H4 arginine 3 methylation.	Arginine	46-54	protein arginine methyltransferase 1	Homo sapiens	197-202
29053970-7	2017	Thus, through SLC38A9, arginine serves as a lysosomal messenger that couples mTORC1 activation to the release from lysosomes of the essential amino acids needed to drive cell growth.	Arginine	23-31	solute carrier family 38 member 9	Homo sapiens	14-21
28757124-6	2017	As for all Kir channels, a cluster of basic residues is present in the N-terminal domain of Kir6.2 and is composed of 5 arginines which are proximal to the GPCR C-ter in the fusion proteins.	Arginine	120-129	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	92-98
15610032-5	2004	The C-terminal of both human and porcine TGFBIp is truncated predominantly after the integrin binding sequence Arg(642)-Gly(643)-Asp(644) (RGD).	Arginine	111-114	transforming growth factor beta induced	Homo sapiens	41-47
28892081-6	2017	Knockdown of A20 or overexpression of Snail1 with mutation of the monoubiquitylated lysine residues into arginine abolishes lung metastasis in mouse xenograft and orthotopic breast cancer models, indicating that A20 and monoubiquitylated Snail1 are required for metastasis.	Arginine	105-113	snail family zinc finger 1	Mus musculus	38-44
15542252-3	2004	Application of the non-NMDA glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) resulted in a 60% reduction in basal arginine release but no change in that of glutamate.	Arginine	139-147	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	23-46
28733204-7	2017	Participants with the genotype XRCC1(Arg194Trp) Arg/Trp+Trp/Trp had a significantly higher OR of RCC than those with the Arg/Arg genotype; the OR and 95% confidence interval was 0.66 (0.45-0.97) after multivariate adjustment.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	31-36
15611175-0	2004	The Drosophila U1-70K protein is required for viability, but its arginine-rich domain is dispensable.	Arginine	65-73	small ribonucleoprotein particle U1 subunit 70K	Drosophila melanogaster	15-21
15611175-5	2004	Surprisingly, and contrary to the current view of U1-70K function, animals carrying a mutant U1-70K protein lacking the arginine-rich domain, which includes two embedded sets of RS dipeptide repeats, have no discernible mutant phenotype.	Arginine	120-128	small ribonucleoprotein particle U1 subunit 70K	Drosophila melanogaster	93-99
28733204-7	2017	Participants with the genotype XRCC1(Arg194Trp) Arg/Trp+Trp/Trp had a significantly higher OR of RCC than those with the Arg/Arg genotype; the OR and 95% confidence interval was 0.66 (0.45-0.97) after multivariate adjustment.	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	31-36
28733204-7	2017	Participants with the genotype XRCC1(Arg194Trp) Arg/Trp+Trp/Trp had a significantly higher OR of RCC than those with the Arg/Arg genotype; the OR and 95% confidence interval was 0.66 (0.45-0.97) after multivariate adjustment.	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	31-36
15590402-1	2004	BACKGROUND AND OBJECTIVES: Arginine 315 in factor VII (FVII) belongs to a solvent-exposed loop involved in direct interaction with the co-factor (tissue factor, TF), in transmission of TF-induced effects and potentially in FVIIa inactivation.	Arginine	27-35	coagulation factor VII	Mus musculus	55-59
28733204-8	2017	The OR of RCC for the combined effect of high urinary 8-OHdG levels and high urinary total arsenic concentration in individuals with a XRCC1(Arg194Trp) Arg/Trp+Trp/Trp genotype was higher than in patients with an Arg/Arg genotype, which was evident in a dose response manner.	Arginine	141-144	X-ray repair cross complementing 1	Homo sapiens	135-140
28733204-8	2017	The OR of RCC for the combined effect of high urinary 8-OHdG levels and high urinary total arsenic concentration in individuals with a XRCC1(Arg194Trp) Arg/Trp+Trp/Trp genotype was higher than in patients with an Arg/Arg genotype, which was evident in a dose response manner.	Arginine	152-155	X-ray repair cross complementing 1	Homo sapiens	135-140
28733204-8	2017	The OR of RCC for the combined effect of high urinary 8-OHdG levels and high urinary total arsenic concentration in individuals with a XRCC1(Arg194Trp) Arg/Trp+Trp/Trp genotype was higher than in patients with an Arg/Arg genotype, which was evident in a dose response manner.	Arginine	152-155	X-ray repair cross complementing 1	Homo sapiens	135-140
28924605-11	2017	Furthermore, top-down proteomic analysis indicates that tPA cleaves FGF23 at multiple arginines including the proconvertase sensitive site R176.	Arginine	86-95	fibroblast growth factor 23	Mus musculus	68-73
15550240-0	2004	Arginine methylation of STAT1: a reassessment.	Arginine	0-8	signal transducer and activator of transcription 1	Homo sapiens	24-29
15364944-0	2004	Arginine methylation of scaffold attachment factor A by heterogeneous nuclear ribonucleoprotein particle-associated PRMT1.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	116-121
28294536-2	2017	We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase (NAGK), which catalyzes the second step of arginine biosynthesis.	Arginine	137-145	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	69-93
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	Arginine	131-141	nitric oxide synthase 1	Rattus norvegicus	242-272
15464999-1	2004	Organotin compounds, triphenyltin (TPT), tributyltin, dibutyltin, and monobutyltin (MBT), showed potent inhibitory effects on both L-arginine oxidation to nitric oxide and L-citrulline, and cytochrome c reduction catalyzed by recombinant rat neuronal nitric oxide synthase (nNOS).	Arginine	131-141	nitric oxide synthase 1	Rattus norvegicus	274-278
15464999-7	2004	The inhibitory effect of organotin compounds (100microM) on L-arginine oxidation of nNOS almost vanished when the amount of CaM was sufficiently increased (150-300microM).	Arginine	60-70	nitric oxide synthase 1	Rattus norvegicus	84-88
28294536-2	2017	We report the isolation and characterization of Arabidopsis thaliana N-acetylglutamate kinase (NAGK), which catalyzes the second step of arginine biosynthesis.	Arginine	137-145	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	95-99
15550149-4	2004	DNA sequencing disclosed a heterozygous G--&gt;A substitution at nucleotide 893, that converts an arginine residue (CGA) to glutamine (CAA), the mutation being designated R298Q.	Arginine	98-106	teashirt zinc finger homeobox 1	Homo sapiens	135-138
28294536-4	2017	Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium.	Arginine	132-140	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	43-47
28294536-4	2017	Heterologous expression of the Arabidopsis NAGK gene in a NAGK-deficient Escherichia coli strain fully restores bacterial growth on arginine-deficient medium.	Arginine	132-140	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	58-62
28294536-5	2017	nagk mutant pollen tubes grow more slowly than wild type pollen tubes and the phenotype is restored by either specifically through complementation by NAGK in pollen, or exogenous supplementation of arginine.	Arginine	198-206	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	0-4
15469977-2	2004	By positional cloning, we demonstrate that a novel spontaneous mutation ringelschwanz (rs) in the mouse is caused by a point mutation in Lrp6, leading to an amino acid substitution of tryptophan for the evolutionarily conserved residue arginine at codon 886 (R886W).	Arginine	236-244	low density lipoprotein receptor-related protein 6	Mus musculus	137-141
28294536-9	2017	The embryo-defective phenotype in nagk/NAGK plants cannot be rescued by watering nagk/NAGK plants with arginine or ornithine supplementation.	Arginine	103-111	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	39-43
28740232-3	2017	In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg).	Arginine	156-164	sequestosome 1	Homo sapiens	42-45
15531553-2	2004	Recently, a single nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at LYP codon 620 has been shown to be associated with type 1 diabetes and other autoimmune disorders.	Arginine	72-80	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	113-116
15482857-6	2004	The application of "M-I pair mutagenesis" and inclusion of a C-terminal arginine residue are then sufficient to solve this problem and convert one lead peptide into a functional complementary peptide mini-receptor inhibitor of IL-18.	Arginine	72-80	interleukin 18	Homo sapiens	227-232
28740232-3	2017	In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg).	Arginine	156-164	sequestosome 1	Homo sapiens	46-52
28740232-3	2017	In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal degrons (N-degrons), including arginine (Nt-Arg).	Arginine	156-164	sequestosome 1	Homo sapiens	53-67
28733581-8	2017	Mutations of charged residues in the aspartic acid-arginine-tyrosine motif of the M2 muscarinic receptor, but not intracellular loop 3, significantly impaired the voltage-dependence of RGS4 function.	Arginine	51-59	regulator of G-protein signaling 4 S homeolog	Xenopus laevis	185-189
15531073-2	2004	Trans-membrane l-arginine transportation mediated by the isozymes of cationic amino acid transporters (e.g. CAT-1, CAT-2, CAT-2A, and CAT-2B) is one crucial regulatory mechanism that regulates iNOS activity.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	115-120
28684763-8	2017	Significant inhibition of CAT1-mediated uptake of L-homoarginine by L-arginine already occurred in the physiological concentration range.	Arginine	68-78	solute carrier family 7 member 1	Homo sapiens	26-30
15531073-2	2004	Trans-membrane l-arginine transportation mediated by the isozymes of cationic amino acid transporters (e.g. CAT-1, CAT-2, CAT-2A, and CAT-2B) is one crucial regulatory mechanism that regulates iNOS activity.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	122-128
15531073-2	2004	Trans-membrane l-arginine transportation mediated by the isozymes of cationic amino acid transporters (e.g. CAT-1, CAT-2, CAT-2A, and CAT-2B) is one crucial regulatory mechanism that regulates iNOS activity.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	134-140
28684763-9	2017	Taken together these data demonstrate that L-homoarginine is a substrate of CAT1, CAT2A and CAT2B and that CAT1 is a key site with regard to physiological relevance and interactions with related substrates such as L-arginine.	Arginine	214-224	solute carrier family 7 member 1	Homo sapiens	107-111
28713411-8	2017	Genetic and bioinformatics analyses of HKT1;4 of contrasting genotypes (Kharchia-65 and HD-2329) revealed deletions, transitions, and transversions resulting into altered structure, loss of conserved motifs (Ser-Gly-Gly-Gly and Gly-Arg) and function in salt-sensitive (HD-2329) genotype.	Arginine	232-235	cation transporter HKT1	Triticum aestivum	39-45
15500895-2	2004	Retrospective studies have suggested that adverse effects occur in patients with a genetic polymorphism that results in homozygosity for arginine (Arg/Arg), rather than glycine (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor.	Arginine	137-145	adrenoceptor beta 2	Homo sapiens	219-244
15500895-2	2004	Retrospective studies have suggested that adverse effects occur in patients with a genetic polymorphism that results in homozygosity for arginine (Arg/Arg), rather than glycine (Gly/Gly), at aminoacid residue 16 of the beta2-adrenergic receptor.	Arginine	147-150	adrenoceptor beta 2	Homo sapiens	219-244
28658303-10	2017	Also, SIK3 induced pro-inflammatory arginine metabolism, as evidenced by upregulation of the enzymes iNOS and ASS-1, along with downregulation of anti-inflammatory enzymes, arginase-1 and ornithine decarboxylase.	Arginine	36-44	SIK family kinase 3	Homo sapiens	6-10
15454439-4	2004	In the Kir3.1/Kir3.4 channel, mutation of an extracellular arginine residue, R155, in the Kir3.4 subunit markedly reduced K+ activation of the channel.	Arginine	59-67	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	14-20
15454439-4	2004	In the Kir3.1/Kir3.4 channel, mutation of an extracellular arginine residue, R155, in the Kir3.4 subunit markedly reduced K+ activation of the channel.	Arginine	59-67	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	90-96
28580921-8	2017	Here, the structure of apo hTS crystallized in the active form with sulfate ions coordinated by the arginine residue that binds dUMP is reported.	Arginine	100-108	APC down-regulated 1	Homo sapiens	27-30
28285332-3	2017	Arginine:glycine amidinotransferase (AGAT) converts Arg to hArg and guanidinoacetate (GAA).	Arginine	0-3	glycine amidinotransferase	Homo sapiens	37-41
28438540-7	2017	A systematic amino acid scanning (Ala, Leu, Phe, Ser, Glu, or Arg) of desamino OT (dOT) at positions 2, 3, 4, 5, 7, and 8 revealed the tolerability for the substitution at positions 7 and 8.	Arginine	62-65	oxytocin/neurophysin I prepropeptide	Homo sapiens	79-81
28062568-3	2017	Collectrin is also expressed in endothelial cells throughout the vasculature, where it regulates L-arginine uptake.	Arginine	97-107	collectrin, amino acid transport regulator	Mus musculus	0-10
28555614-3	2017	In this study, differentially expressed genes (DEGs) regulated by c-Abl/Arg were identified, and related cellular functions and associated pathways were investigated.	Arginine	72-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	66-71
28555614-7	2017	RESULTS A total of 1,034 DEGs were significantly regulated by c-Abl/Arg (399 were up-regulated and 635 were down-regulated after c-Abl/Arg double knockdown).	Arginine	68-71	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	62-67
28555614-7	2017	RESULTS A total of 1,034 DEGs were significantly regulated by c-Abl/Arg (399 were up-regulated and 635 were down-regulated after c-Abl/Arg double knockdown).	Arginine	68-71	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	129-134
28555614-7	2017	RESULTS A total of 1,034 DEGs were significantly regulated by c-Abl/Arg (399 were up-regulated and 635 were down-regulated after c-Abl/Arg double knockdown).	Arginine	135-138	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	62-67
28555614-9	2017	CONCLUSIONS Our data collectively support the hypothesis that c-Abl/Arg regulate differential gene expression, providing new insights into the biological functions of c-Abl and Arg.	Arginine	68-71	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	167-172
28555614-9	2017	CONCLUSIONS Our data collectively support the hypothesis that c-Abl/Arg regulate differential gene expression, providing new insights into the biological functions of c-Abl and Arg.	Arginine	177-180	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	62-67
28538181-5	2017	Knockdown of fumarase in human kidney cells and vascular endothelial cells resulted in decreased levels of malate, aspartate, L-arginine, and NO.	Arginine	126-136	fumarate hydratase	Homo sapiens	13-21
27997760-7	2017	The in vitro PDT efficiency of Ce6-loaded HA-Arg-PEA nanocomplex was examined in CD44 positive MDA-MB-435/MDR multidrug resistant melanoma cells.	Arginine	45-48	CD44 molecule (Indian blood group)	Homo sapiens	81-85
27997760-8	2017	CD44-mediated uptake of Ce6-loaded HA-Arg-PEA nanocomplex significantly improved Ce6 level in MDA-MB-435/MDR cells within short incubation time, and the PDT efficiency in inhibiting multidrug resistant tumor cells was also enhanced at higher Ce6 concentrations.	Arginine	38-41	CD44 molecule (Indian blood group)	Homo sapiens	0-4
28487700-8	2017	Further studies showed that IL-10 promoter DNA hypomethylation, rather than histone modification, corresponded to the l-arginine-induced increase in IL-10 production by neonatal CD4+ T cells.	Arginine	118-128	interleukin 10	Homo sapiens	28-33
28487700-8	2017	Further studies showed that IL-10 promoter DNA hypomethylation, rather than histone modification, corresponded to the l-arginine-induced increase in IL-10 production by neonatal CD4+ T cells.	Arginine	118-128	interleukin 10	Homo sapiens	149-154
28487700-9	2017	These results suggest that l-arginine modulates neonatal Tregs through the regulation of IL-10 promoter DNA methylation.	Arginine	27-37	interleukin 10	Homo sapiens	89-94
28275114-5	2017	This is reversed by proteasome inhibition, depletion of endogenous Dok-4 or lysine-to-arginine mutation of putative Elk-4 ubiquitination sites.	Arginine	86-94	ETS transcription factor ELK4	Canis lupus familiaris	116-121
28176353-4	2017	TRPA1 and TRPV1 channels are activated by intracellular LPA, but not by extracellular LPA following LPA5 receptor activation with an activity of Ca2+ -independent phospholipase A2 and phospholipase D. Intracellular LPA interaction sites of TRPA1 are KK672-673 and KR977-978 (K: lysine, R: arginine).	Arginine	289-297	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
28161797-4	2017	It was found that 10 mM betaine specifically and almost completely inhibited human and rat SNAT2-mediated [14C]alpha-methylaminoisobutyric acid ([14C]MeAIB) uptake, while 5 mM L-arginine specifically and completely inhibited [3H]glycine uptake via human SNAT4, as well as [14C]MeAIB uptake via rat SNAT4.	Arginine	176-186	solute carrier family 38, member 2	Rattus norvegicus	91-96
27855150-8	2017	The R139Q substitution affects a conserved arginine residue within the DNA-binding domain of FOXF1.	Arginine	43-51	forkhead box F1	Homo sapiens	93-98
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	67-72
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	8-11	adrenoceptor beta 2	Homo sapiens	44-65
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	8-11	adrenoceptor beta 2	Homo sapiens	67-72
28093224-6	2017	Arg/Arg homozygotes at codon 16 required at least two courses of antibiotic therapy administered as a result of a lower respiratory tract infection significantly more frequently than carriers of other polymorphic variants of the ADRB2.	Arginine	0-3	adrenoceptor beta 2	Homo sapiens	229-234
28093224-6	2017	Arg/Arg homozygotes at codon 16 required at least two courses of antibiotic therapy administered as a result of a lower respiratory tract infection significantly more frequently than carriers of other polymorphic variants of the ADRB2.	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	229-234
28093224-9	2017	These data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of COPD.	Arginine	26-29	adrenoceptor beta 2	Homo sapiens	66-71
28093224-9	2017	These data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of COPD.	Arginine	30-33	adrenoceptor beta 2	Homo sapiens	66-71
28334039-5	2017	Using siRNA we inhibited the L-Arg cationic amino acid transporter system y+ (CAT1) expression and examined its effects on L-Arg transport activity and IL-1beta-mediated NF-kappaB-activation.	Arginine	29-34	solute carrier family 7 member 1	Homo sapiens	78-82
28334039-8	2017	System y+ CAT1 siRNA decreased CAT1 expression, L-Arg transport activity and attenuated the inhibitory effects of L-Arg on NF- kappaB activity.	Arginine	48-53	solute carrier family 7 member 1	Homo sapiens	10-14
28306503-6	2017	Expression of arginine-rich DPRs in cells induced spontaneous stress granule assembly that required both eIF2alpha phosphorylation and G3BP.	Arginine	14-22	eukaryotic translation initiation factor 2A	Homo sapiens	105-114
15362851-1	2004	Delta-crystallin is directly related to argininosuccinate lyase (ASL), and catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate.	Arginine	135-143	argininosuccinate lyase	Homo sapiens	40-63
15362851-1	2004	Delta-crystallin is directly related to argininosuccinate lyase (ASL), and catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate.	Arginine	135-143	argininosuccinate lyase	Homo sapiens	65-68
28306503-6	2017	Expression of arginine-rich DPRs in cells induced spontaneous stress granule assembly that required both eIF2alpha phosphorylation and G3BP.	Arginine	14-22	G3BP stress granule assembly factor 1	Homo sapiens	135-139
28039273-4	2017	Results: Generally, the antibiotic resistance genes detected using bioinformatic methods were concordant, but only ARG-ANNOT included sat2 .	Arginine	115-118	streptothricin acetyltransferase	Escherichia coli	134-138
15356163-1	2004	The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin.	Arginine	44-47	GC vitamin D binding protein	Homo sapiens	85-110
15356163-1	2004	The chemotactic activity of C5a and C5a des Arg can be enhanced significantly by the vitamin D-binding protein (DBP), also known as Gc-globulin.	Arginine	44-47	GC vitamin D binding protein	Homo sapiens	132-143
28212316-0	2017	Succinimide Formation from an NGR-Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain.	Arginine	132-140	reticulon 4 receptor	Homo sapiens	30-33
15317797-3	2004	Consistent with previous reports, OmpT was found to exhibit a virtual requirement for Arg in the P1 position and a slightly less stringent preference for this residue in the P1" position (P1 and P1" are the residues immediately prior to and following the scissile bond).	Arginine	86-89	outer membrane protease	Escherichia coli	34-38
15331664-7	2004	We show that the recruitment of the two serine/arginine-rich (SR) proteins SF2/ASF and SRp30c requires the presence of stress-induced satellite III transcripts.	Arginine	47-55	serine and arginine rich splicing factor 1	Homo sapiens	75-78
15331664-7	2004	We show that the recruitment of the two serine/arginine-rich (SR) proteins SF2/ASF and SRp30c requires the presence of stress-induced satellite III transcripts.	Arginine	47-55	serine and arginine rich splicing factor 1	Homo sapiens	79-82
15334382-8	2004	Our findings suggest that the beta(2)-AR Arg(16)-Gly genotype influences T-C and LDL-C levels in an age-specific manner, that it may interact with beta(3)-AR Trp(64)-Arg genotypes to influence longitudinal T-C and LDL-C profiles, and that the effect of combined beta(2)/beta(3)-AR genotypes on T-C and LDL-C profiles may differ among race/sex groups.	Arginine	41-44	adrenoceptor beta 2	Homo sapiens	30-40
28212316-10	2017	This study is the first to propose a possible catalytic role for the Arg side chain in the NGR deamidation.	Arginine	69-72	reticulon 4 receptor	Homo sapiens	91-94
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Arginine	130-138	TSC complex subunit 2	Homo sapiens	51-55
28166740-1	2017	BACKGROUND: Cystinuria is an inherited metabolic disease that is caused by defects in two genes, SLC3A1 and SLC7A9, which result in a renal reabsorptive defect of cystine and other dibasic amino acids, including ornithine, arginine, and lysine.	Arginine	223-231	solute carrier family 7 member 9	Homo sapiens	108-114
15340059-7	2004	We demonstrated a novel catalytic mechanism of the TSC2 GAP and Rheb that TSC2 uses a catalytic "asparagine thumb" instead of the arginine finger found in Ras-GAP.	Arginine	130-138	TSC complex subunit 2	Homo sapiens	74-78
15317450-4	2004	Receptor-ligand docking studies using full-atom flexible ligand and flexible receptor suggested that binding of the antagonist to the RXRalpha antagonist conformation was favored because the salt bridge that formed between the retinoid carboxylate and the RXRalpha helix H5 arginine-321 was far stronger than that formed on its binding to the agonist conformation.	Arginine	274-282	retinoid X receptor alpha	Homo sapiens	134-142
15317450-4	2004	Receptor-ligand docking studies using full-atom flexible ligand and flexible receptor suggested that binding of the antagonist to the RXRalpha antagonist conformation was favored because the salt bridge that formed between the retinoid carboxylate and the RXRalpha helix H5 arginine-321 was far stronger than that formed on its binding to the agonist conformation.	Arginine	274-282	retinoid X receptor alpha	Homo sapiens	256-264
27400413-5	2017	We identify PADI2 as one of the most highly upregulated transcripts in BMMSCs from both MGUS and MM patients, and that through its enzymatic deimination of histone H3 arginine 26, PADI2 activity directly induces the upregulation of interleukin-6 expression.	Arginine	167-175	peptidyl arginine deiminase 2	Homo sapiens	12-17
27400413-5	2017	We identify PADI2 as one of the most highly upregulated transcripts in BMMSCs from both MGUS and MM patients, and that through its enzymatic deimination of histone H3 arginine 26, PADI2 activity directly induces the upregulation of interleukin-6 expression.	Arginine	167-175	peptidyl arginine deiminase 2	Homo sapiens	180-185
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Arginine	175-178	malate dehydrogenase 2	Homo sapiens	186-189
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Arginine	25-34	sirtuin 7	Mus musculus	59-64
15273299-7	2004	The general-base-catalyzed hydroxyl proton abstraction from substrate concerted with hydride transfer to the C5 of PQQ is assisted by hydrogen-bonding to the C5=O by Wat1 and Arg 324 in MDH and by Wat89 and Arg 228 in sGDH.	Arginine	207-210	malate dehydrogenase 2	Homo sapiens	186-189
28147277-5	2017	Mutating both lysines to arginines abolishes the effect of SIRT7 on Akt activity through FKBP51 deacetylation.	Arginine	25-34	FK506 binding protein 5	Mus musculus	89-95
15150266-4	2004	In contrast to wild type, ATPase of mutants was not inhibited by MgADP-fluoroaluminate or MgADP-fluoroscandium, showing the Arg side chain is required for wild-type transition state formation.	Arginine	124-127	ATPase	Escherichia coli	26-32
28120869-4	2017	The main ARG carriers (Pseudomonas) that were substantially enriched in the SMT group had lower levels of denitrifying functional genes, which could imply that denitrification is influenced more by bacterial dynamics than by abundance of ARGs under antibiotic pressures.	Arginine	9-12	serpin family A member 2 (gene/pseudogene)	Homo sapiens	238-242
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	54-58
15126500-5	2004	YIH1 interacts with the same GCN1 fragment that binds GCN2, and this YIH1-GCN1 interaction requires Arg-2259 in GCN1 in vitro and in full-length GCN1 in vivo, as found for GCN2-GCN1 interaction.	Arginine	100-103	serine/threonine-protein kinase GCN2	Saccharomyces cerevisiae S288C	172-176
27503676-7	2017	Such a proline-arginine sequence has been associated with the arginine methyl-transferases CARM1 and PRMT5.	Arginine	15-23	coactivator associated arginine methyltransferase 1	Homo sapiens	91-96
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Arginine	80-88	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	3-9
27838299-5	2017	Whole-cell patch clamp studies with several omega-Aga IVA analogs indicate that both the hydrophobic C-terminal tail and an Arg patch in the core region of omega-Aga IVA are critical for Cav2.1 blockade.	Arginine	124-127	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	187-193
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Arginine	80-88	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	121-128
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Arginine	90-93	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	3-9
15196988-5	2004	In CYP2A6, the amino acid residues at position 117 and 372 are valine (Val) and arginine (Arg), respectively; whereas in CYP2A13, they are alanine (Ala) and histidine (His).	Arginine	90-93	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	121-128
15196988-6	2004	Kinetic analysis revealed that the catalytic efficiency (Vmax/Km) of the CYP2A6 Val(117)--&gt; Ala and Arg(372)--&gt; His mutants was drastically reduced (0.41 and 0.64 versus 3.23 for the wild-type CYP2A6 protein).	Arginine	103-106	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	73-79
15196988-6	2004	Kinetic analysis revealed that the catalytic efficiency (Vmax/Km) of the CYP2A6 Val(117)--&gt; Ala and Arg(372)--&gt; His mutants was drastically reduced (0.41 and 0.64 versus 3.23 for the wild-type CYP2A6 protein).	Arginine	103-106	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	199-205
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	argininosuccinate lyase	Homo sapiens	54-77
15219987-4	2004	Interestingly, the substrates, L-Arg and N-hydroxy-L-Arg (NHA), altered CO binding behavior in that the binding rate was modified to CO concentration-independent, both with and without H4B.	Arginine	31-36	H4 clustered histone 4	Homo sapiens	185-188
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	argininosuccinate lyase	Homo sapiens	79-82
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	solute carrier family 7 member 1	Homo sapiens	119-125
15198676-5	2004	In addition, SRp20, a member of serine-arginine (SR) protein family of splicing factors was found to facilitate exclusion of exon 10 in a dosage-dependent manner.	Arginine	39-47	serine and arginine rich splicing factor 3	Homo sapiens	13-18
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	201-237
29055959-9	2017	The transcripts involved in arginine bioavailability: Argininosuccinate lyase (ASL), Solute Carrier Family1, member 7 (SLC7A1) and Arginase 1 (ARG1) and Asymmetric Dimethyl Arginine (ADMA) metabolism: Protein arginine methyltransferase 1 (PRMT1) and Dimethylarginine dimethylaminohydrolase 2 (DDAH2) also showed differential expression.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	239-244
28158539-0	2017	Defects in methylation of arginine 37 on CENP-A/Cse4 are compensated by the ubiquitin ligase complex Ubr2/Mub1.	Arginine	26-34	Mub1p	Saccharomyces cerevisiae S288C	106-110
28854440-0	2017	The Nrf2/HO-1 Pathway Mediates the Antagonist Effect of L-Arginine On Renal Ischemia/Reperfusion Injury in Rats.	Arginine	56-66	heme oxygenase 1	Rattus norvegicus	9-13
15238080-1	2004	Citrullination (deimination is an enzymatic, posttranslational conversion of arginine residues to citrulline residues) of joint-associated self-proteins may be a possible mechanism in the induction of autoimmune CD4 T-cell responses in rheumatoid arthritis.	Arginine	77-85	CD4 antigen	Mus musculus	212-215
27863399-5	2016	We found that a WRN variant containing a phenylalanine residue at position 1074 and an arginine at position 1367 (eYFP-WRN(F-R)) possesses more affinity for DNA-PKc, KU86, KU70, and PARP1 than a variant containing a leucine at position 1074 and a cysteine at position 1367 (eYFP-WRN(L-C)).	Arginine	87-95	X-ray repair cross complementing 6	Homo sapiens	172-176
15165856-9	2004	Two alternative conformations of the Arg84(E10) guanidium group were observed, suggesting that it participates in ligand binding to Cgb, as is the case for Arg(E10) of Aplysia Mb and Lys(E10) of Ngb.	Arginine	37-40	neuroglobin	Homo sapiens	195-198
27834681-8	2016	Such a result provided direct evidence for distributive arginine dimethylation, which means the monomethylated substrate has to be released to solution and rebind with PRMT1 before it undergoes further methylation.	Arginine	56-64	protein arginine methyltransferase 1	Homo sapiens	168-173
15158302-4	2004	After 5 h, a 57% reduction in circulating arginine was obtained by intravenous injections of arginase (SAL/SAL: 138+/-7; ASE/SAL: 59+/-10 microM, P&lt;0.05).	Arginine	42-50	satin-like	Mus musculus	93-119
27934952-0	2016	Effect of arginine on oligomerization and stability of N-acetylglutamate synthase.	Arginine	10-18	N-acetylglutamate synthase	Homo sapiens	55-81
15158302-4	2004	After 5 h, a 57% reduction in circulating arginine was obtained by intravenous injections of arginase (SAL/SAL: 138+/-7; ASE/SAL: 59+/-10 microM, P&lt;0.05).	Arginine	42-50	satin-like	Mus musculus	103-106
15158302-5	2004	Reduced circulating arginine caused a reduction in plasma arginine flux (SAL/SAL: 82+/-6; ASE/SAL: 63+/-5 nmol/(10 g b.w.	Arginine	20-28	satin-like	Mus musculus	73-76
15158302-5	2004	Reduced circulating arginine caused a reduction in plasma arginine flux (SAL/SAL: 82+/-6; ASE/SAL: 63+/-5 nmol/(10 g b.w.	Arginine	20-28	satin-like	Mus musculus	77-80
27934952-3	2016	In some bacteria bifunctional N-acetylglutamate synthase-kinase (NAGS-K) catalyzes the first two steps of L-arginine biosynthesis.	Arginine	106-116	N-acetylglutamate synthase	Homo sapiens	30-56
15158302-5	2004	Reduced circulating arginine caused a reduction in plasma arginine flux (SAL/SAL: 82+/-6; ASE/SAL: 63+/-5 nmol/(10 g b.w.	Arginine	20-28	satin-like	Mus musculus	77-80
27934952-4	2016	L-arginine inhibits NAGS in bacteria, fungi, and plants and activates NAGS in mammals.	Arginine	0-10	N-acetylglutamate synthase	Homo sapiens	20-24
27934952-4	2016	L-arginine inhibits NAGS in bacteria, fungi, and plants and activates NAGS in mammals.	Arginine	0-10	N-acetylglutamate synthase	Homo sapiens	70-74
27934952-8	2016	Different effects of L-arginine on oligomerization of NAGS may have implications for efforts to determine the three-dimensional structure of mammalian NAGS.	Arginine	21-31	N-acetylglutamate synthase	Homo sapiens	54-58
27934952-8	2016	Different effects of L-arginine on oligomerization of NAGS may have implications for efforts to determine the three-dimensional structure of mammalian NAGS.	Arginine	21-31	N-acetylglutamate synthase	Homo sapiens	151-155
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Arginine	369-377	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	112-116
15175299-4	2004	Ten putative transcriptional units of 28 genes were inducible by ArgR and arginine, including all known ArgR-regulated operons under aerobic conditions.	Arginine	74-82	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	104-108
15175299-7	2004	The effect of arginine on the expression of these genes was confirmed by lacZ fusion studies and by DNA binding studies with purified ArgR.	Arginine	14-22	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	134-138
15175299-9	2004	These results indicate that ArgR is important in control of arginine and glutamate metabolism and that arginine and ArgR may have a redundant effect in inducing the uptake systems of certain compounds.	Arginine	60-68	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	28-32
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Arginine	369-377	eukaryotic translation initiation factor 2A	Homo sapiens	117-126
15354414-5	2004	Weak association was found between the XRCC1 Arg/Arg and Gln/Gln variants and the risk of colorectal cancer (OR = 1.28; 95% CI 1.00-1.84 and OR = 1.13; 95% CI 0.85-2.34, respectively).	Arginine	45-48	X-ray repair cross complementing 1	Homo sapiens	39-44
27613409-4	2016	Using wild-type as well as Gcn2 knockout and unphosphorylatable eIF2alpha mutant MEFs, we characterized a novel GCN2/eIF2alpha phosphorylation-independent, but ATF4-dependent, pathway that upregulates the expression of CARE-containing genes in MEFs lacking GCN2 or phosphorylatable eIF2alpha when these cells are exposed to methionine-deficient, and to a lesser extent arginine- or histidine-deficient, medium.	Arginine	369-377	eukaryotic translation initiation factor 2A	Homo sapiens	117-126
15354414-5	2004	Weak association was found between the XRCC1 Arg/Arg and Gln/Gln variants and the risk of colorectal cancer (OR = 1.28; 95% CI 1.00-1.84 and OR = 1.13; 95% CI 0.85-2.34, respectively).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	39-44
27614253-3	2016	This cycle indicates that argininosuccinate synthase (ASS) catalyzes l-citrulline (l-cit) conversion to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms l-arginine (l-arg), the substrate for NO synthesis.	Arginine	199-209	argininosuccinate lyase	Homo sapiens	163-186
27656708-4	2016	We show that common genetic variations at the KLKB1 and F12 loci are strongly associated with serum L-arginine levels.	Arginine	100-110	coagulation factor XII	Homo sapiens	56-59
15153491-2	2004	It has been reported that STAT1 activity is regulated by methylation of a conserved arginine residue in the N-terminal domain.	Arginine	84-92	signal transducer and activator of transcription 1	Homo sapiens	26-31
27656708-5	2016	The G allele of single nucleotide polymorphism (SNP) rs71640036 (T/G) in KLKB1 is associated with lower serum L-arginine concentrations (10 micromol/l per allele copy, p=1x10-24), while allele T of rs2545801 (T/C) near the F12 gene is associated with lower serum L-arginine levels (7 micromol/l per allele copy, p=7x10-12).	Arginine	110-120	coagulation factor XII	Homo sapiens	223-226
27771248-8	2016	Structure-function analysis using dynamin2 deletion fragments identified the proline/arginine-rich domain (PRD) of dynamin2 as indispensable for invadopodia formation and invasiveness of T24 cells.	Arginine	85-93	dynamin 2	Homo sapiens	115-123
15082769-3	2004	We have shown that mutations of two arginine-rich motifs (ARMs), an acidic region, or two CCCH zinc fingers affect the ability of Su(s) to downregulate the expression of an insertion mutant allele and to autoregulate genomic su(s) transgenes.	Arginine	36-44	Su(S)	Drosophila melanogaster	130-135
27895589-2	2016	The most commonly occurring residue on cTnI associated with familial hypertrophic cardiomyopathy (FHC) is arginine (R), which is also the most common residue at which multiple mutations occur.	Arginine	106-114	troponin I3, cardiac type	Homo sapiens	39-43
15131772-7	2004	However, in 327 subjects with normal glucose tolerance (NGT), the subjects with Arg/Gln or Gln/Gln + A/A haplotype showed significantly higher serum insulin levels and homeostasis model assessment (HOMA) index than those with Arg/Arg + A/A haplotype and Arg/Gln or Gln/Gln + A/G or G/G haplotype.	Arginine	80-83	N-acetylglutamate synthase	Homo sapiens	230-237
27895589-3	2016	Two FHC mutations are known to occur at cTnI arginine 204, R204C and R204H, and both are associated with poor clinical prognosis.	Arginine	45-53	troponin I3, cardiac type	Homo sapiens	40-44
27686613-5	2016	In particular, we found significant overexpression of miR-21-3p in acini treated with caerulein and TLC-S. We further looked at the expression of miR-21-3p in caerulein, l-arginine, and caerulein + LPS-induced acute pancreatitis mouse models and found 12-, 21-, and 50-fold increased expression in the pancreas, respectively.	Arginine	170-180	microRNA 181a-1	Mus musculus	146-155
14976203-5	2004	The TMs involved in the recognition of both calcilytics include residues located in TM3 (Arg-680(3.28), Phe-684(3.32), and Phe-688(3.36)).	Arginine	89-92	tropomyosin 3	Homo sapiens	84-87
15094065-1	2004	The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the consensus sequence Ser-Tyr-Gly-Gln-Ser in the N-terminus.	Arginine	157-165	TATA-box binding protein associated factor 15	Homo sapiens	16-26
26952721-4	2016	The COI gene begins with CGA (arginine) in all sequenced gelechioids, including M. albilinella and D. ustalella, reinforcing the feature as a synapomorphic trait, at least in the Gelechioidea.	Arginine	30-38	COI	Mesophleps albilinella	4-7
14722075-4	2004	In contrast to the 3-hydroxyl of cholesterol, the 3-O-sulfate group makes additional direct hydrogen bonds with three residues of the RORalpha ligand binding domain, namely NH-Gln(289), NH-Tyr(290), and NH1-Arg(370).	Arginine	207-210	RAR related orphan receptor A	Homo sapiens	134-142
27392937-0	2016	Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy.	Arginine	13-23	microRNA 155	Rattus norvegicus	101-108
15047208-9	2004	Although the frequency of overall GSTT1 null genotype was significantly lower in cervical carcinoma patients with high-risk HPV infection (OR = 0.3, 95% CI: 0.1-1.0), almost 2-fold increased risk was observed among women with GSTT1 null and Arg/Arg genotype (OR = 1.9, 95% CI: 0.7-5.4).	Arginine	241-244	glutathione S-transferase theta 1	Homo sapiens	34-39
15047208-9	2004	Although the frequency of overall GSTT1 null genotype was significantly lower in cervical carcinoma patients with high-risk HPV infection (OR = 0.3, 95% CI: 0.1-1.0), almost 2-fold increased risk was observed among women with GSTT1 null and Arg/Arg genotype (OR = 1.9, 95% CI: 0.7-5.4).	Arginine	245-248	glutathione S-transferase theta 1	Homo sapiens	34-39
14982563-2	2004	Type-2 cationic amino acid transporter (CAT-2) mediation of trans-membrane L-arginine (L-Arg) transportation has been identified as one of the crucial regulatory mechanisms involved in the formation of NO by iNOS.	Arginine	87-92	solute carrier family 7 member 2	Rattus norvegicus	40-45
14982563-13	2004	Regulation of L-Arg uptake by modulating the expression regulation of induced CAT-2 and CAT-2B might be a potential target for therapies against renal pathologic conditions related to NO overproduction.	Arginine	14-19	solute carrier family 7 member 2	Rattus norvegicus	78-83
14982563-13	2004	Regulation of L-Arg uptake by modulating the expression regulation of induced CAT-2 and CAT-2B might be a potential target for therapies against renal pathologic conditions related to NO overproduction.	Arginine	14-19	solute carrier family 7 member 2	Rattus norvegicus	88-94
27392937-11	2016	In conclusion, both ibuprofen and L-arginine delayed the development of behavioral and histologic changes of DN, with concomitant suppression of spinal miR-155 and NO level.	Arginine	34-44	microRNA 155	Rattus norvegicus	152-159
27556423-3	2016	Site-directed mutagenesis performed on highly conserved arginine residues located in the positively charged channel connecting mMDH and CS active sites led to the identification of CS(R65A) which retained high catalytic efficiency.	Arginine	56-64	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	127-131
15077869-7	2004	Sequencing of a full-length alpha-Gal A cDNA from the proband indicated a C-T transition at codon 220, resulting in substitution of the predictable termination for arginine (R220X).	Arginine	164-172	galactosidase alpha	Homo sapiens	28-39
27601476-0	2016	Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly.	Arginine	0-8	G3BP stress granule assembly factor 1	Homo sapiens	26-31
14993643-4	2004	Results presented here demonstrate that ASF/SF2 requires only one of the two RNA-recognition motifs (RRMs) present in the protein for its efficient recruitment to the ring-like structures, where viral pre-mRNAs are transcribed and processed, and that the arginine/serine-rich (RS) domain in ASF/SF2 is both redundant and insufficient for the translocation of the protein to active viral RNA polymerase II genes in adenovirus-infected cells.	Arginine	255-263	serine and arginine rich splicing factor 1	Homo sapiens	40-47
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	intercellular adhesion molecule 1	Homo sapiens	0-6
27601476-4	2016	Here, we examined the potent SG-nucleating protein Ras-GAP SH3-binding protein 1 (G3BP1), and found that G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase (PRMT) 1 and PRMT5 in its RGG domain.	Arginine	152-160	G3BP stress granule assembly factor 1	Homo sapiens	51-80
14978237-7	2004	ICAM-1 promoter activities induced by the overexpression of wild-type JAK1- and PLC-gamma2 were blocked by the PLCgamma2 mutant or the dominant-negative PKCalpha (Lys--&gt;Arg), c-Src (Lys--&gt;Met), or STAT1 (Y701M) mutants, but not by dominant-negative STAT3 (DN) mutants.	Arginine	172-175	signal transducer and activator of transcription 1	Homo sapiens	203-208
27601476-4	2016	Here, we examined the potent SG-nucleating protein Ras-GAP SH3-binding protein 1 (G3BP1), and found that G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase (PRMT) 1 and PRMT5 in its RGG domain.	Arginine	152-160	G3BP stress granule assembly factor 1	Homo sapiens	82-87
27601476-4	2016	Here, we examined the potent SG-nucleating protein Ras-GAP SH3-binding protein 1 (G3BP1), and found that G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase (PRMT) 1 and PRMT5 in its RGG domain.	Arginine	152-160	G3BP stress granule assembly factor 1	Homo sapiens	105-110
27601476-4	2016	Here, we examined the potent SG-nucleating protein Ras-GAP SH3-binding protein 1 (G3BP1), and found that G3BP1 is differentially methylated on specific arginine residues by protein arginine methyltransferase (PRMT) 1 and PRMT5 in its RGG domain.	Arginine	152-160	protein arginine methyltransferase 1	Homo sapiens	173-216
27601476-6	2016	Arsenite stress quickly and reversibly decreased asymmetric arginine methylation on G3BP1.	Arginine	60-68	G3BP stress granule assembly factor 1	Homo sapiens	84-89
27546596-6	2016	Thus, specific host-guest chemistry between aggregation-prone proteins and lysine/arginine binders rescues cell viability and restores animal health in models of AD, PD, and TTR amyloidosis.	Arginine	82-90	transthyretin	Homo sapiens	174-177
15039778-7	2004	Genetic or pharmacological interference with Abl (and the related kinase Arg) resulted in a marked decrease in Rac activation induced by physiological doses of growth factors.	Arginine	73-76	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	45-48
27568928-1	2016	In HLA-DQ8-associated celiac disease, TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ T cells recognize the immunodominant DQ8-glia-alpha1 epitope, whereupon a non-germline-encoded arginine residue played a key role in binding HLA-DQ8-glia-alpha1.	Arginine	170-178	T cell receptor alpha variable 26-2	Homo sapiens	38-46
15915719-6	2004	Arginine dose 0.1 M does not influence streptokinase adsorption on mini-plasminogen and decreases the value of alpha-2-antiplasmin binding with mini-plasminogen by 50%.	Arginine	0-8	serpin family F member 2	Homo sapiens	111-130
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	33-41	T cell receptor alpha variable 26-2	Homo sapiens	164-172
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	148-156	T cell receptor alpha variable 26-2	Homo sapiens	164-172
27568928-6	2016	Surprisingly, a germline-encoded arginine residue within the CDR1alpha loop of the TRAV20+ TCR substituted for the role of the non-germline-encoded arginine in the TRAV26-2+-TRBV9+ and TRAV8-3+-TRBV6+ TCRs.	Arginine	148-156	T cell receptor beta variable 9	Homo sapiens	174-179
14625280-3	2004	The sequential binding of two cAMPs releases active C. We describe here the properties of RIIbeta and two mutant RIIbeta subunits, engineered by converting a conserved Arg to Lys in each cAMP-binding domain thereby yielding a protein that contains one intact, high affinity cAMP-binding site and one defective site.	Arginine	168-171	protein kinase cAMP-dependent type II regulatory subunit beta	Homo sapiens	113-120
27074718-9	2016	Agm upregulates expression of mRNAs SLC7A1, agmatinase and OAZ2 while the combination of Arg and Agm decreased expression of mRNAs for ODC1, SLC7A1, OAZ1 and OAZ3 by oTr1 cells.	Arginine	89-92	ornithine decarboxylase, structural 1	Mus musculus	135-139
27074718-9	2016	Agm upregulates expression of mRNAs SLC7A1, agmatinase and OAZ2 while the combination of Arg and Agm decreased expression of mRNAs for ODC1, SLC7A1, OAZ1 and OAZ3 by oTr1 cells.	Arginine	89-92	ornithine decarboxylase antizyme 1	Mus musculus	149-153
14561219-9	2004	This supports a two-translocation-pathway model for antiporter b(0,+), in which the efflux pathway in the rBAT(R365W)/b(0,+)AT holotransporter is defective for arginine translocation or dissociation.	Arginine	160-168	solute carrier family 7 member 9	Homo sapiens	118-126
27074718-9	2016	Agm upregulates expression of mRNAs SLC7A1, agmatinase and OAZ2 while the combination of Arg and Agm decreased expression of mRNAs for ODC1, SLC7A1, OAZ1 and OAZ3 by oTr1 cells.	Arginine	89-92	ornithine decarboxylase antizyme 3	Mus musculus	158-162
27426075-9	2016	DMSO significantly increased the abundance of phosphorylated CAT-1 (the inactive form) and phosphorylated PKC-alpha protein, an effect that was attenuated by l-arginine.	Arginine	158-168	solute carrier family 7 member 1	Homo sapiens	61-66
27447401-3	2016	L-arginine enhances expression of endothelial nitric oxide synthase (eNOS), angiogenic factor, in skeletal muscle.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	34-67
14580238-0	2004	Characterization of a pseudoachondroplasia-associated mutation (His587--&gt;Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP).	Arginine	76-79	cartilage oligomeric matrix protein	Homo sapiens	127-162
14580238-0	2004	Characterization of a pseudoachondroplasia-associated mutation (His587--&gt;Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP).	Arginine	76-79	cartilage oligomeric matrix protein	Homo sapiens	164-168
14580238-1	2004	We have introduced a pseudoachondroplasia-associated mutation (His(587)--&gt;Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells.	Arginine	77-80	cartilage oligomeric matrix protein	Homo sapiens	129-133
14580238-1	2004	We have introduced a pseudoachondroplasia-associated mutation (His(587)--&gt;Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells.	Arginine	77-80	cartilage oligomeric matrix protein	Homo sapiens	135-170
14580238-6	2004	Also a COMP His(587)--&gt;Arg fragment encompassing the calcium-binding repeats and the C-terminal collagen-binding domain bound collagens equally well as the corresponding wild-type protein.	Arginine	26-29	cartilage oligomeric matrix protein	Homo sapiens	7-11
27447401-3	2016	L-arginine enhances expression of endothelial nitric oxide synthase (eNOS), angiogenic factor, in skeletal muscle.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	69-73
27447401-7	2016	L-arginine supplementation attenuated the decrease in both eNOS expression and C/F ratio, although it did not increase integrated SDH activity in skeletal muscle.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	59-63
14698416-2	2004	The three polymorphisms under investigation were an Arg --&gt; Gln substitution at codon 399 in exon 10 of XRCC1, a Thr --&gt; Met substitution at codon 241 in exon 7 of XRCC3 and an Ile --&gt; Thr substitution at codon 401 in exon 4 of XRCC4.	Arginine	52-55	X-ray repair cross complementing 1	Homo sapiens	107-112
27050801-0	2016	Impact of the Arg 16 allele of the B2AR gene on the effect of withdrawal of LABA in patients with moderate to severe asthma.	Arginine	14-17	adrenoceptor beta 2	Homo sapiens	35-39
27050801-8	2016	CONCLUSIONS: Withdrawal of LABA therapy in asthmatics with the Arg/Arg genotype at the 16th amino acid position of B2AR did not lead to significant improvement in AM PEFR.	Arginine	63-66	adrenoceptor beta 2	Homo sapiens	115-119
14711628-4	2004	Since OmpT Asp(97) is proposed to interact with the P1" amino acid of its substrates, OmpT variants with variations at Asp(97) were constructed by replacing this amino acid with 19 natural amino acids to alter the cleavage specificity at Arg (P1)-Xaa (P1").	Arginine	238-241	outer membrane protease	Escherichia coli	6-10
14711628-4	2004	Since OmpT Asp(97) is proposed to interact with the P1" amino acid of its substrates, OmpT variants with variations at Asp(97) were constructed by replacing this amino acid with 19 natural amino acids to alter the cleavage specificity at Arg (P1)-Xaa (P1").	Arginine	238-241	outer membrane protease	Escherichia coli	86-90
14711628-5	2004	The variant OmpT that had a methionine at this position, but not the wild-type OmpT, efficiently cleaved a fusion protein containing the amino acid sequence -Arg-Arg-Arg-Ala-Arg downward arrow motilin, in which motilin is a model peptide with a phenylalanine at the N terminus.	Arginine	158-161	outer membrane protease	Escherichia coli	12-16
27050801-8	2016	CONCLUSIONS: Withdrawal of LABA therapy in asthmatics with the Arg/Arg genotype at the 16th amino acid position of B2AR did not lead to significant improvement in AM PEFR.	Arginine	67-70	adrenoceptor beta 2	Homo sapiens	115-119
27520967-0	2016	Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	92-96
14711628-5	2004	The variant OmpT that had a methionine at this position, but not the wild-type OmpT, efficiently cleaved a fusion protein containing the amino acid sequence -Arg-Arg-Arg-Ala-Arg downward arrow motilin, in which motilin is a model peptide with a phenylalanine at the N terminus.	Arginine	162-165	outer membrane protease	Escherichia coli	12-16
14711628-5	2004	The variant OmpT that had a methionine at this position, but not the wild-type OmpT, efficiently cleaved a fusion protein containing the amino acid sequence -Arg-Arg-Arg-Ala-Arg downward arrow motilin, in which motilin is a model peptide with a phenylalanine at the N terminus.	Arginine	162-165	outer membrane protease	Escherichia coli	12-16
14711628-5	2004	The variant OmpT that had a methionine at this position, but not the wild-type OmpT, efficiently cleaved a fusion protein containing the amino acid sequence -Arg-Arg-Arg-Ala-Arg downward arrow motilin, in which motilin is a model peptide with a phenylalanine at the N terminus.	Arginine	162-165	outer membrane protease	Escherichia coli	12-16
14763822-8	2004	Moreover, the OmpT-mediated cleavage occurred at a novel site (Arg-Ser).	Arginine	63-66	outer membrane protease	Escherichia coli	14-18
14699505-6	2004	Tyrosine and serine phosphorylation of STAT1 were intact, but methylation of STAT1 on arginine 31 was reduced.	Arginine	86-94	signal transducer and activator of transcription 1	Homo sapiens	77-82
14613973-1	2004	Identical proline--&gt;arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis syndromes, respectively.	Arginine	23-31	fibroblast growth factor receptor 3	Homo sapiens	140-145
15493055-8	2004	Mean C3a/C3a(des Arg) was higher in Auto-C (P &lt; 0.001): 4,724 ng/ml (N = 10; range: 2,400-7 ,360) and &gt; 4,149 ng/ml (N = 30; 2,408- &gt; 6,430) after 3 and 18 months storage, respectively.	Arginine	17-20	complement C3	Homo sapiens	5-8
15493055-8	2004	Mean C3a/C3a(des Arg) was higher in Auto-C (P &lt; 0.001): 4,724 ng/ml (N = 10; range: 2,400-7 ,360) and &gt; 4,149 ng/ml (N = 30; 2,408- &gt; 6,430) after 3 and 18 months storage, respectively.	Arginine	17-20	complement C3	Homo sapiens	9-12
15493717-7	2004	CONCLUSION: At codon 16 of the beta2-AR gene, maternal Arg-16 homozygosity protects against, and Gly-16 predisposes to spontaneous preterm birth.	Arginine	55-58	adrenoceptor beta 2	Homo sapiens	31-39
15207362-1	2004	The brain substrates involved in the pharmacological effects of neuropeptide FF (NPFF, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2) including interactions with opioid systems, were investigated with the [14C]-2-deoxyglucose ([14C]-2-DG) autoradiography technique in mouse.	Arginine	111-114	neuropeptide FF-amide peptide precursor	Mus musculus	64-79
14657365-6	2003	Finally, three mutations associated with AVED involve arginine residues that are grouped together on the surface of ATTP.	Arginine	54-62	alpha tocopherol transfer protein	Homo sapiens	116-120
14504281-3	2003	We show that mutation of charged glutamate and arginine residues behind the selectivity filter in the Kir3.1/Kir3.4 K+ channel reduces or abolishes K+ selectivity, comparable with previously reported effects in the Kir2.1 K+ channel.	Arginine	47-55	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	109-115
14534363-9	2003	In contrast, an antagonist rhodamine-Ac-Cys-Glu-His-(d-Nal)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (HS014) bound to and colocalized with MC4R-GFP on the cell surface and did not stimulate receptor internalization.	Arginine	60-63	melanocortin 4 receptor	Homo sapiens	134-138
14534352-3	2003	The two major enzymes PRMT1 (type I) and PRMT5 (type II) preferentially methylate arginines located in RG-rich clusters.	Arginine	82-91	protein arginine methyltransferase 1	Homo sapiens	22-27
15127941-4	2003	It has been hypothesized that the Arg-Phe-Phe (111-113) human AGRP amino acids may be mimicking the melanocortin agonist Phe-Arg-Trp (7-9) residue interactions with the melanocortin receptors that are important for both receptor molecular recognition and stimulation.	Arginine	34-37	agouti related neuropeptide	Homo sapiens	62-66
14609340-2	2003	In a single turnover with HDiNOS, 5-methyl-H(4)B forms a very stable radical, 5-methyl-H(3)B(*), that accumulates in the arginine reaction to approximately 60% of the HDiNOS concentration and decays approximately 400-fold more slowly than H(3)B(*) (0.0003 vs 0.12 s(-1)).	Arginine	121-129	H4 clustered histone 4	Homo sapiens	43-48
14609340-2	2003	In a single turnover with HDiNOS, 5-methyl-H(4)B forms a very stable radical, 5-methyl-H(3)B(*), that accumulates in the arginine reaction to approximately 60% of the HDiNOS concentration and decays approximately 400-fold more slowly than H(3)B(*) (0.0003 vs 0.12 s(-1)).	Arginine	121-129	H3 clustered histone 4	Homo sapiens	87-92
14609340-2	2003	In a single turnover with HDiNOS, 5-methyl-H(4)B forms a very stable radical, 5-methyl-H(3)B(*), that accumulates in the arginine reaction to approximately 60% of the HDiNOS concentration and decays approximately 400-fold more slowly than H(3)B(*) (0.0003 vs 0.12 s(-1)).	Arginine	121-129	H3 clustered histone 4	Homo sapiens	239-244
14609340-4	2003	The activity of 5-methyl-H(4)B-saturated FLiNOS and HDiNOS is similar to that when H(4)B is bound: arginine is hydroxylated to NHA, and NHA is oxidized exclusively to citrulline and (*)NO.	Arginine	99-107	H4 clustered histone 4	Homo sapiens	25-30
14609340-4	2003	The activity of 5-methyl-H(4)B-saturated FLiNOS and HDiNOS is similar to that when H(4)B is bound: arginine is hydroxylated to NHA, and NHA is oxidized exclusively to citrulline and (*)NO.	Arginine	99-107	H4 clustered histone 4	Homo sapiens	83-88
14609340-6	2003	The catalytic activity of 4-amino-H(4)B-bound FLiNOS and HDiNOS resembles that of pterin-free iNOS: the hydroxylation of arginine is very unfavorable (&lt;2% that of H(4)B-bound iNOS), and NHA is oxidized to a mixture of amino acid products (citrulline and cyanoornithine) and NO(-) rather than (*)NO.	Arginine	121-129	H4 clustered histone 4	Homo sapiens	34-39
14609340-6	2003	The catalytic activity of 4-amino-H(4)B-bound FLiNOS and HDiNOS resembles that of pterin-free iNOS: the hydroxylation of arginine is very unfavorable (&lt;2% that of H(4)B-bound iNOS), and NHA is oxidized to a mixture of amino acid products (citrulline and cyanoornithine) and NO(-) rather than (*)NO.	Arginine	121-129	H4 clustered histone 4	Homo sapiens	166-171
12960019-3	2003	Systematic alteration of GR DBD amino acids in these chimeras to VDR DBD residues identified arg-49 and lys-53, just C-terminal of the P-box within the base recognition alpha-helix of human VDR (hVDR), as the only two amino acids among 36 differences required to convert the GR core zinc finger domain to that of the VDR.	Arginine	93-96	vitamin D receptor	Homo sapiens	190-193
12960019-3	2003	Systematic alteration of GR DBD amino acids in these chimeras to VDR DBD residues identified arg-49 and lys-53, just C-terminal of the P-box within the base recognition alpha-helix of human VDR (hVDR), as the only two amino acids among 36 differences required to convert the GR core zinc finger domain to that of the VDR.	Arginine	93-96	vitamin D receptor	Homo sapiens	190-193
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Arginine	206-209	vitamin D receptor	Homo sapiens	97-101
12960019-4	2003	Gel mobility shift and 1,25-dihydroxyvitamin D3-stimulated transcription assays verified that an hVDR-GR DBD chimera is functional on the rat osteocalcin VDRE with only the conservative change of lys-49 to arg, and of the negatively charged glu-53 to a basic amino acid (lys or arg).	Arginine	235-238	vitamin D receptor	Homo sapiens	97-101
12960019-5	2003	Thus, for RXR heterodimerizing receptors like VDR, the P-box requires redefinition and expansion to include a DNA specificity element corresponding to arg-49 and lys-53 of hVDR.	Arginine	151-154	vitamin D receptor	Homo sapiens	172-176
14571272-6	2003	Sequencing of the PAX9 gene revealed a missense mutation in the beginning of the paired domain of the molecule, an arginine-to-tryptophan amino-acid change occurring in a position absolutely conserved in all sequenced paired box genes.	Arginine	115-123	paired box 9	Canis lupus familiaris	18-22
14571272-7	2003	A mutation of the homologous arginine of PAX6 has been shown to affect the target DNA specificity of PAX6.	Arginine	29-37	paired box protein Pax-6	Canis lupus familiaris	41-45
14571272-7	2003	A mutation of the homologous arginine of PAX6 has been shown to affect the target DNA specificity of PAX6.	Arginine	29-37	paired box protein Pax-6	Canis lupus familiaris	101-105
14668357-2	2003	Recessive mutations in ras2 and cyr1, as well as elevated dosage of PDE2, allowed cox2::arg8m-G66S to support Arg prototrophy.	Arginine	110-113	adenylate cyclase	Saccharomyces cerevisiae S288C	32-36
14650112-1	2003	BACKGROUND: It has been argued that arginine replacement in locus 16 (Arg16) of beta 2 adrenergic receptor with glycin (Gly16) increases asthma severity, while glutamin replacement in locus 27 (Gln27) with glutamic acid (Glu27) decreases it.	Arginine	36-44	adrenoceptor beta 2	Homo sapiens	80-106
14572769-2	2003	NO is synthesized from L-arginine by three different isozymes of nitric oxide synthase (nNOS, iNOS and eNOS).	Arginine	23-33	nitric oxide synthase 1	Rattus norvegicus	88-92
14572769-2	2003	NO is synthesized from L-arginine by three different isozymes of nitric oxide synthase (nNOS, iNOS and eNOS).	Arginine	23-33	nitric oxide synthase 3	Rattus norvegicus	103-107
14581554-6	2003	For fibrillarin, the first 80 amino acids, which contain the glycine-arginine-rich region (the GAR domain), was determined to be the domain interactive with N. The N protein was able to bind to the full-length genomic RNA of PRRSV, and the RNA binding domain was identified as the region overlapping with the nuclear localization signal situated at positions 41 to 47.	Arginine	69-77	fibrillarin	Homo sapiens	4-15
14643949-10	2003	The Arg/Arg genotype in XRCC1 codon 399 was associated with increased risk of radiation-induced subcutaneous fibrosis.	Arginine	4-7	X-ray repair cross complementing 1	Homo sapiens	24-29
14643949-10	2003	The Arg/Arg genotype in XRCC1 codon 399 was associated with increased risk of radiation-induced subcutaneous fibrosis.	Arginine	8-11	X-ray repair cross complementing 1	Homo sapiens	24-29
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Arginine	161-164	sulfite oxidase	Homo sapiens	57-59
14567685-2	2003	Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc.	Arginine	161-164	sulfite oxidase	Homo sapiens	178-180
14567685-7	2003	In the crystal structure of chicken SO, Arg 138, the equivalent of Arg 160 in human SO, is involved in the formation of a positively charged sulfite binding site [Kisker, C., Schindelin, H., Pacheco, A., Wehbi, W., Garnett, R. M., Rajagopalan, K. V., Enemark, J. H., Rees, D. C. (1997) Cell 91, 973-983].	Arginine	40-43	sulfite oxidase	Homo sapiens	36-38
14567685-7	2003	In the crystal structure of chicken SO, Arg 138, the equivalent of Arg 160 in human SO, is involved in the formation of a positively charged sulfite binding site [Kisker, C., Schindelin, H., Pacheco, A., Wehbi, W., Garnett, R. M., Rajagopalan, K. V., Enemark, J. H., Rees, D. C. (1997) Cell 91, 973-983].	Arginine	67-70	sulfite oxidase	Homo sapiens	36-38
14567685-9	2003	In the R160Q mutant, the IET rate constant at pH 6.0 was decreased by nearly 3 orders of magnitude relative to wild type, which indicates that the positive charge of Arg 160 is essential for efficient IET in human SO.	Arginine	166-169	sulfite oxidase	Homo sapiens	214-216
14499613-6	2003	A docking model using the crystal structure of integrin alphaVbeta3 suggests that the Arg binds to the propeller domain, and Asp to the betaA domain.	Arginine	86-89	integrin subunit alpha V	Homo sapiens	47-67
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Arginine	120-123	solute carrier family 2 member 1	Homo sapiens	38-43
12970085-11	2003	There are sequence homologies between GLUT1 and the ligand-binding domain (LBD) of hAR containing the amino-acid triads Arg 126, Thr 30 and Asn 288, and Arg 126, Thr 30 and Asn 29, with similar 3D topology to the polar groups binding 3-keto and 17-beta OH steroid groups in hAR LBD.	Arginine	153-156	solute carrier family 2 member 1	Homo sapiens	38-43
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Arginine	71-74	X-ray repair cross complementing 1	Homo sapiens	4-9
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Arginine	71-74	X-ray repair cross complementing 1	Homo sapiens	4-9
12847105-3	2003	It has been previously shown that a transmembrane arginine and the cytoplasmic domain of GPVI are required for association with the FcR gamma-chain in immortalized cell lines.	Arginine	50-58	Fc epsilon receptor Ig	Rattus norvegicus	132-141
12963686-0	2003	Restrictive cardiomyopathy in familial amyloidosis TTR-Arg-50.	Arginine	55-58	transthyretin	Homo sapiens	51-54
12966927-0	2003	Restrictive cardiomyopathy in familial amyloidosis TTR-Arg-50.	Arginine	55-58	transthyretin	Homo sapiens	51-54
14602524-3	2003	A cohort of 211 French vinyl chloride workers were genotyped for the XRCC1 codon 399 polymorphism (CGG&gt;CAG; Arg&gt;Gln).	Arginine	111-114	X-ray repair cross complementing 1	Homo sapiens	69-74
12941912-4	2003	TAXREB803 is an SR-related protein composed of 2,752 amino acids including numerous arginine/serine (RS) motifs.	Arginine	84-92	serine/arginine repetitive matrix 2	Homo sapiens	0-9
12799365-7	2003	Among various synthetic substrates tested, L-RAP revealed a preference for arginine, establishing that the enzyme is a novel arginine aminopeptidase with restricted substrate specificity.	Arginine	75-83	endoplasmic reticulum aminopeptidase 2	Homo sapiens	43-48
12873795-7	2003	Arginine-induced insulin release was also augmented by xenin-8 (by 40%; p&lt;0.05).	Arginine	0-8	insulin	Canis lupus familiaris	17-24
12904028-5	2003	An important design principle, that stabilization of fibrillar dispersions requires of the order of one unit of net positive or negative charge per peptide molecule, is first demonstrated and then used to design an 11 amino acid peptide P(11)-3 (CH(3)CO-Gln-Gln-Arg-Phe-Gln-Trp-Gln-Phe-Gln-Gln-Gln-NH(2)) whose self-assembly behavior is independent of pH (1 &lt; pH &lt; 10).	Arginine	262-265	signal transducer and activator of transcription 2	Homo sapiens	237-244
12878203-6	2003	Kinetic studies indicated that hK6 cleaved with much higher efficiency after Arg than Lys and with a preference for Ser or Pro in the P2 position.	Arginine	77-80	kallikrein related peptidase 6	Homo sapiens	31-34
12885877-4	2003	Here, we report that an ion pair between glutamate 229 and arginine 314 in the intracellular COOH terminus of Kir6.2 is critical for maintaining channel activity.	Arginine	59-67	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	110-116
12866078-3	2003	GMP in [Pt(bpm)(Arg)](GMP).5 H(2)O was revealed to be bound through the pi-pi stacking and guanidinium-phosphate hydrogen bonds.	Arginine	16-19	5'-nucleotidase, cytosolic II	Homo sapiens	0-3
12866078-3	2003	GMP in [Pt(bpm)(Arg)](GMP).5 H(2)O was revealed to be bound through the pi-pi stacking and guanidinium-phosphate hydrogen bonds.	Arginine	16-19	5'-nucleotidase, cytosolic II	Homo sapiens	22-25
12847256-6	2003	Surprisingly, the beta stalk region also restored functional activity to an inactive CD8alpha variant, carrying an Ala mutation at Arg(8) (R8A), to a level similar to that of wild-type CD8alphabeta.	Arginine	131-134	CD8a molecule	Homo sapiens	85-93
27520967-3	2016	Here we show that in mammalian cells, AUF1 p45 is consistently modified by arginine methylation of its C terminus.	Arginine	75-83	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	38-44
27520967-8	2016	Arginine methylation of AUF1 p45 thus represents a specific determinant of its RNA chaperone activity while functioning as a WNV host factor.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	24-28
27604544-5	2016	Crystal structures of the anabaenopeptins B, C and F bound to the surrogate protease carboxypeptidase B revealed the binding modes of these large (~850 Da) compounds in detail and explained the observed SAR, i.e. the strong dependence of the potency on a basic (Arg, Lys) exocyclic residue that addressed the S1" binding pocket, and a broad tolerance towards substitutions in the pentacyclic ring that acted as a plug of the active site.	Arginine	262-265	carboxypeptidase B1	Homo sapiens	85-103
12812828-3	2003	L-Arginine (1 mM), an NO donor, enhanced the heat-induced depression of the activity of hippocampal CA1 neurons.	Arginine	0-10	carbonic anhydrase 1	Homo sapiens	100-103
27346274-12	2016	In regard to Arg(127) in TM3, both hydrogen-bonding and charge-charge interactions contribute to the high-affinity/selectivity for Bantag-1.	Arginine	13-16	tropomyosin 3	Homo sapiens	25-28
12814971-5	2003	L-Arginine, but not D-arginine, protects nNOS from this time-dependent inactivation, suggesting an active site directed event.	Arginine	0-10	nitric oxide synthase 1	Rattus norvegicus	41-45
12794637-5	2003	Contoured surface loops shape the active site by cleft, thus explaining furin"s stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets.	Arginine	106-114	crystallin gamma F, pseudogene	Homo sapiens	118-127
27477308-5	2016	Cold temperature-induced CIRP overexpression and translocation were shown to be dependent on arginine methylation in vitro.	Arginine	93-101	cold inducible RNA binding protein	Rattus norvegicus	25-29
12796783-3	2003	Abl1 (previously known as Abl) and the Abl1-related gene product Abl2 (previously known as Arg) define a family of tyrosine kinases that regulate actin structure and presynaptic axon guidance.	Arginine	91-94	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	0-3
12796783-3	2003	Abl1 (previously known as Abl) and the Abl1-related gene product Abl2 (previously known as Arg) define a family of tyrosine kinases that regulate actin structure and presynaptic axon guidance.	Arginine	91-94	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	39-43
27387499-4	2016	We have focused our attention on active-site residues of PRMT7 from the protozoan Trypanosoma brucei We have designed 26 single and double mutations in the active site, including residues in the Glu-Xaa8-Glu (double E) loop and the Met-Gln-Trp sequence of the canonical Thr-His-Trp (THW) loop known to interact with the methyl-accepting substrate arginine.	Arginine	347-355	protein arginine methyltransferase 7	Homo sapiens	57-62
12633501-6	2003	In lower organisms, NAGS is feedback-inhibited by L-arginine, whereas mammalian NAGS activity is significantly enhanced by this amino acid.	Arginine	50-60	N-acetylglutamate synthase	Homo sapiens	20-24
12633501-7	2003	The NAGS genes of bacteria, fungi and mammals are more diverse than other arginine-biosynthesis and urea-cycle genes.	Arginine	74-82	N-acetylglutamate synthase	Homo sapiens	4-8
12756332-1	2003	In this report, we have investigated the impact of arginine methylation on the Gar1, Nop1, and Nsr1 nucleolar proteins in Saccharomyces cerevisiae.	Arginine	51-59	Nsr1p	Saccharomyces cerevisiae S288C	95-99
12756332-12	2003	In contrast, arginine methylation is required for the export of the nuclear RNA-binding proteins Npl3p, Hrp1p, and Nab2p.	Arginine	13-21	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	97-102
27706616-7	2016	In the dominant model, we found that the Arg/Trp + Trp/Trp genotype of XRCC1 Arg194Trp could significantly elevate the susceptibility of developing glioma (OR = 1.79, 95%CI = 1.07-0.94).	Arginine	41-44	X-ray repair cross complementing 1	Homo sapiens	71-76
12644451-4	2003	Mutational analysis of the alpha 1b-AR revealed that the binding site for mu 2 does not involve canonical YXX Phi or dileucine motifs but a stretch of eight arginines on the receptor C-tail.	Arginine	157-166	adrenoceptor alpha 1B	Homo sapiens	27-38
27183873-0	2016	Methylation of arginine by PRMT1 regulates Nrf2 transcriptional activity during the antioxidative response.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	27-32
12547830-2	2003	Recently, we noticed the ends of loop E-2 are linked by an ion pair between residues Arg-177 and Asp-190, near the highly conserved disulfide bond.	Arginine	85-88	cystatin 12, pseudogene	Homo sapiens	38-41
27183873-4	2016	Here we demonstrate that the arginine methyltransferase-1 (PRMT1) methylates Nrf2 protein at a single residue of arginine 437, both in vitro and in vivo.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	59-64
27293070-1	2016	The docking approach for the screening of designed small molecule ligands, led to the identification of a critical arginine residue in peptide deformylase for spiro cyclopropyl PDF inhibitor"s extra hydrophobic binding, providing us a useful tool for searching more efficient PDF inhibitors to fight for horrifying antibiotics resistance.	Arginine	115-123	peptide deformylase (mitochondrial)	Rattus norvegicus	177-180
27363609-6	2016	Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP and affected the Myo9b-mediated cell migration.	Arginine	27-35	myosin IXB	Homo sapiens	79-84
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Arginine	106-114	signal transducer and activator of transcription 1	Mus musculus	0-5
12591923-8	2003	STAT1 preferentially binds peptides with the motif phosphotyrosine-(aspartic acid/glutamic acid)-(proline/arginine)-(arginine/proline/glutamine), whereby a negatively charged amino acid at +1 excludes a proline at +2 and vice versa.	Arginine	117-125	signal transducer and activator of transcription 1	Mus musculus	0-5
12719257-4	2003	The first 52 amino acids of Vpu (HV1H2) have been simulated, which are thought to be embedded in a fully hydrated lipid bilayer and to consist of a transmembrane helix (helix-1) connected via a flexible linker region, including a Glu-Tyr-Arg (EYR) motif, with a second helix (helix-2) residing with its helix long axis on the bilayer surface.	Arginine	238-241	Vpu	Human immunodeficiency virus 1	28-31
12711671-7	2003	The C-terminal half of human ELAC2 was able to remove a 3" trailer from pre-tRNA(Arg), while the N-terminal half failed to do so.	Arginine	81-84	elaC ribonuclease Z 2	Homo sapiens	29-34
12702756-2	2003	As a prototype, we developed a targeting device that is based on the formation of a covalent bond of defined stoichiometry between a 1,3-diketone derivative of an integrin alpha(v)beta(3) and alpha(v)beta(5) targeting Arg-Gly-Asp peptidomimetic and the reactive lysine of aldolase antibody 38C2.	Arginine	218-221	integrin subunit alpha V	Homo sapiens	163-187
12655043-6	2003	After stimulation by cytokines, uptake of L-arginine negatively regulates the phosphorylation status of the eukaryotic initiation factor (eIF2 alpha), which, in turn, regulates translation of iNOS mRNA.	Arginine	42-52	eukaryotic translation initiation factor 2A	Homo sapiens	138-148
12655043-8	2003	As the kinase activity of GCN2 is activated by phosphorylation, these findings suggest that GCN2 activity represents a proximal step in the iNOS translational regulation by availability of l-arginine.	Arginine	189-199	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	26-30
12655043-8	2003	As the kinase activity of GCN2 is activated by phosphorylation, these findings suggest that GCN2 activity represents a proximal step in the iNOS translational regulation by availability of l-arginine.	Arginine	189-199	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	92-96
12569093-1	2003	The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and Arg.	Arginine	79-82	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-7
12569093-4	2003	The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the Arg C-terminal region.	Arginine	110-113	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-31
12569093-5	2003	Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl.	Arginine	19-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	13-18
12569093-5	2003	Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl.	Arginine	19-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	126-131
12569093-5	2003	Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl.	Arginine	72-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	13-18
12569093-5	2003	Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl.	Arginine	72-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	126-131
12569093-6	2003	The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg.	Arginine	71-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-66
12569093-6	2003	The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg.	Arginine	71-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-89
12569093-6	2003	The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg.	Arginine	118-121	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-66
12569093-6	2003	The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg.	Arginine	118-121	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-89
12569093-7	2003	The functional significance of the c-Abl-Arg interaction is supported by the demonstration that both c-Abl and Arg are required for ROS-induced apoptosis.	Arginine	41-44	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	35-40
12569093-7	2003	The functional significance of the c-Abl-Arg interaction is supported by the demonstration that both c-Abl and Arg are required for ROS-induced apoptosis.	Arginine	41-44	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	101-106
27363609-6	2016	Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP and affected the Myo9b-mediated cell migration.	Arginine	27-35	Rho GTPase activating protein 1	Homo sapiens	85-91
27363609-6	2016	Mutating either of the two arginine fingers impaired the catalytic activity of Myo9b-RhoGAP and affected the Myo9b-mediated cell migration.	Arginine	27-35	myosin IXB	Homo sapiens	109-114
12547827-7	2003	Our data further suggest that potent, yet highly selective, PTP1B inhibitory agents can be acquired by targeting the area defined by residues Lys-41, Arg-47, and Asp-48, in addition to the previously identified second aryl phosphate-binding pocket.	Arginine	150-153	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	60-65
27447620-2	2016	We hypothesized that the conserved arginine cluster (RRR) located within the insert could act as an RXR-type endoplasmic reticulum (ER) retention signal.	Arginine	35-43	retinoid X receptor alpha	Homo sapiens	100-103
12475743-11	2003	In conclusion, in vivo administration of LPS augments glomerular arginine transport through upregulation of steady-state CAT-2 mRNA while downregulating CAT-1 mRNA.	Arginine	65-73	solute carrier family 7 member 2	Rattus norvegicus	121-126
27226634-9	2016	However, similar to another family member, RdmB, it catalyzes the introduction of a hydroxyl group, in the case of NDUFAF5, into Arg-73 in the NDUFS7 subunit of human complex I.	Arginine	129-132	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	143-149
12761287-8	2003	When the lysine(15) residue of Smt3 was substituted with arginine, Smt3 chain-polymerization was abolished.	Arginine	57-65	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	31-35
27256984-8	2016	Furthermore, we found hotspot mutations in the arginine-rich stretch in MAP1LC3A resulting in reduced cleavage of MAP1LC3A by ATG4B both in vitro and in vivo, suggesting a functional implication of this gene mutation in cancer development.	Arginine	47-55	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	72-80
12761287-8	2003	When the lysine(15) residue of Smt3 was substituted with arginine, Smt3 chain-polymerization was abolished.	Arginine	57-65	SUMO family protein SMT3	Saccharomyces cerevisiae S288C	67-71
27256984-8	2016	Furthermore, we found hotspot mutations in the arginine-rich stretch in MAP1LC3A resulting in reduced cleavage of MAP1LC3A by ATG4B both in vitro and in vivo, suggesting a functional implication of this gene mutation in cancer development.	Arginine	47-55	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	114-122
12624182-1	2003	The Ser-Arg (SR)-related protein SRm160 is a coactivator of pre-mRNA splicing.	Arginine	8-11	serine and arginine repetitive matrix 1	Homo sapiens	33-39
26812303-8	2016	We found that the mutation from arginine to glycine leads to the loss of 2 hydrogen bonds and to an unstable structure in the STAS domain of SLC26A6.	Arginine	32-40	solute carrier family 26 member 6	Homo sapiens	141-148
12514189-5	2003	Although the ADAMTS-9 zymogen has many proprotein convertase processing sites, pulse-chase analysis, site-directed mutagenesis, and amino acid sequencing demonstrated that maturation to the active form occurs by selective proprotein convertase (e.g. furin) cleavage of the Arg(287)-Phe(288) bond.	Arginine	273-276	ADAM metallopeptidase with thrombospondin type 1 motif 9	Homo sapiens	13-21
27156075-7	2016	The latter patients also carried missense mutation c.98C>T of the SQSTM1 gene causing a substitution of an arginine with a valine at the position 33 (p.Arg33Val).	Arginine	107-115	sequestosome 1	Homo sapiens	66-72
12519781-2	2003	The mutations (R176Q, R179W, and R179Q) replace Arg residues within a subtilisin-like proprotein convertase (SPC) cleavage site (RXXR motif), leading to protease resistance of FGF23.	Arginine	48-51	fibroblast growth factor 23	Mus musculus	176-181
27309807-8	2016	Our findings demonstrate that CARM1-dependent histone arginine methylation is a crucial nuclear event in autophagy, and identify a new signalling axis of AMPK-SKP2-CARM1 in the regulation of autophagy induction after nutrient starvation.	Arginine	54-62	coactivator associated arginine methyltransferase 1	Homo sapiens	30-35
12598935-3	2003	The activity of PKC was increased by Ang II (0.01-10 micromol/L) in a dose-dependent manner, but decreased by NO precursor L-arginine (L-Arg) (10 micromol/L-10 mmol/L) in a dose-dependent manner in cultured neonatal rat cardiomyocytes.	Arginine	123-133	protein kinase C, gamma	Rattus norvegicus	16-19
12598935-3	2003	The activity of PKC was increased by Ang II (0.01-10 micromol/L) in a dose-dependent manner, but decreased by NO precursor L-arginine (L-Arg) (10 micromol/L-10 mmol/L) in a dose-dependent manner in cultured neonatal rat cardiomyocytes.	Arginine	135-140	protein kinase C, gamma	Rattus norvegicus	16-19
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Arginine	18-23	protein kinase C, gamma	Rattus norvegicus	83-86
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Arginine	18-23	protein kinase C, gamma	Rattus norvegicus	100-103
12598935-4	2003	Pretreatment with L-Arg (100 micromol/L) decreased significantly Ang II -activated PKC activity and PKC activity induced by phorbol 12-myristate 13-acetate (PMA) ( 10 micromol/L), a PKC activator.	Arginine	18-23	protein kinase C, gamma	Rattus norvegicus	100-103
27297692-5	2016	Our data establish that GCN2 is involved in the inhibition of mTORC1 upon leucine or arginine deprivation.	Arginine	85-93	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	24-28
12598935-5	2003	Pretreatment with N(G)-nitro-L-argingie methyl ester (L-NAME), a nitric oxide synthase (NOS) blocker, may inhibit significantly the role of L-Arg on Ang II - and PMA-activated PKC activity.	Arginine	140-145	protein kinase C, gamma	Rattus norvegicus	176-179
12393390-4	2003	The transmembrane forms of LIR9 contain a short cytoplasmic domain and a charged arginine residue within the transmembrane region that is likely to mediate its association with another coreceptor.	Arginine	81-89	leukocyte immunoglobulin like receptor A5	Homo sapiens	27-31
27297692-6	2016	However, the activation of GCN2 alone is not sufficient to inhibit mTORC1 activity, indicating that leucine and arginine exert regulation via additional mechanisms.	Arginine	112-120	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	27-31
12565863-1	2003	The C-half of cisplatin resistance-associated overexpressed protein (CROP), an SR-related protein, comprises domains rich in arginine and glutamate residues (RE domain), and is rich in arginine and serine residues (RS domain).	Arginine	125-133	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	14-67
26928127-3	2016	YPQ1 and AVT1, which are involved in the vacuolar uptake of lysine/arginine and histidine, respectively, were deleted in addition to ypq2Delta and ypq3Delta.	Arginine	67-75	cationic amino acid transporter	Saccharomyces cerevisiae S288C	0-4
12565863-1	2003	The C-half of cisplatin resistance-associated overexpressed protein (CROP), an SR-related protein, comprises domains rich in arginine and glutamate residues (RE domain), and is rich in arginine and serine residues (RS domain).	Arginine	125-133	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	69-73
12565863-1	2003	The C-half of cisplatin resistance-associated overexpressed protein (CROP), an SR-related protein, comprises domains rich in arginine and glutamate residues (RE domain), and is rich in arginine and serine residues (RS domain).	Arginine	185-193	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	14-67
12565863-1	2003	The C-half of cisplatin resistance-associated overexpressed protein (CROP), an SR-related protein, comprises domains rich in arginine and glutamate residues (RE domain), and is rich in arginine and serine residues (RS domain).	Arginine	185-193	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	69-73
27025389-0	2016	Arginine Supplementation Recovered the IFN-gamma-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2alpha Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells.	Arginine	0-8	eukaryotic translation initiation factor 2A	Bos taurus	124-133
12566380-1	2003	Restrictive cardiomyopathy in familial amyloidosis TTR-Arg-50.	Arginine	55-58	transthyretin	Homo sapiens	51-54
27025389-7	2016	Furthermore, mechanistic analysis confirmed that IFN-gamma mediated autophagy by depleting arginine and inhibiting the general control nonderepressible-2 kinase (GCN2)/eukaryotic initiation factor 2alpha (eIF2alpha) signaling pathway in BMECs.	Arginine	91-99	interferon gamma	Bos taurus	49-58
12675514-6	2003	Tryptase TC30 cleaved peptide substrates with Arg at the P1 position, and preferentially substrates with the Ser-Ile-Gin-Ser-Arg sequence corresponding to the HA cleavage site sequence of the A/PR/8/34 influenza virus.	Arginine	46-49	tryptase beta 2	Mus musculus	0-8
27025389-8	2016	Then, it was found that arginine supplementation could attenuate IFN-gamma-induced autophagy and recover milk synthesis to some extent.	Arginine	24-32	interferon gamma	Bos taurus	65-74
12675514-6	2003	Tryptase TC30 cleaved peptide substrates with Arg at the P1 position, and preferentially substrates with the Ser-Ile-Gin-Ser-Arg sequence corresponding to the HA cleavage site sequence of the A/PR/8/34 influenza virus.	Arginine	125-128	tryptase beta 2	Mus musculus	0-8
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Arginine	230-233	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	33-39
12608726-5	2003	The CAB levels in GCF were determined by fluorospectrometry, using Z-Arg-Arg-MCA as the substrate and by Western blotting analysis.	Arginine	69-72	cathepsin B	Homo sapiens	4-7
12586692-2	2003	Members of a cluster of hydrophobic residues of Cdc42p were changed to alanine and/or arginine.	Arginine	86-94	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	48-54
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Arginine	230-233	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
27044868-4	2016	The ubiquitin-conjugating enzyme Ube2R1/2 has exquisite specificity for Lys 48, and computational docking of Ube2R1/2 and ubiquitin predicts that Lys 48 is guided to the active site through a key electrostatic interaction between Arg 54 on ubiquitin and Asp 143 on Ube2R1/2.	Arginine	230-233	cell division cycle 34, ubiqiutin conjugating enzyme	Homo sapiens	109-115
26818738-5	2016	Two novel KCNH1 mutations (p.R357Q and p.R357P), found in three patients, were located at the evolutionally highly conserved arginine in the channel voltage-sensor domain (S4).	Arginine	125-133	potassium voltage-gated channel subfamily H member 1	Homo sapiens	10-15
26957205-3	2016	To date, the recognized targets of thrombin cleavage and activation for signaling are PAR1 and PAR4, in which thrombin cleaves at a conserved target arginine to reveal a tethered ligand.	Arginine	149-157	F2R like thrombin or trypsin receptor 3	Homo sapiens	95-99
18238167-2	2003	The objective of our work is to improve the GA-based ARG matching procedures leading to a faster convergence rate and better quality mapping between a scene ARG and a set of given model ARGs.	Arginine	53-56	serpin family A member 2 (gene/pseudogene)	Homo sapiens	186-190
18238167-2	2003	The objective of our work is to improve the GA-based ARG matching procedures leading to a faster convergence rate and better quality mapping between a scene ARG and a set of given model ARGs.	Arginine	157-160	serpin family A member 2 (gene/pseudogene)	Homo sapiens	186-190
26865631-3	2016	Residues Arg-309 and Asp-85 (rat P2X4 numbering) are highly conserved throughout the P2X family and were involved in loss-of-function polymorphism in human P2X receptors.	Arginine	9-12	purinergic receptor P2X 4	Rattus norvegicus	33-37
26890358-4	2016	In this work, the unprecedented increased enzymatic activity and intracellular penetration achieved by the association of a human recombinant GLA to nanoliposomes functionalized with Arginine-Glycine-Aspartic acid (RGD) peptides is reported.	Arginine	183-191	galactosidase alpha	Homo sapiens	142-145
12806204-14	2003	The mesenteric vascular expression of eNOs protein was significantly higher in BH4 but not in L-ARG, compared with Nx rats.	Arginine	94-99	nitric oxide synthase 3	Rattus norvegicus	38-42
12493827-8	2003	A single additional mutation of arginine to aspartic acid allowed for recovery of native structure and increased the thermal stability of the designed Src-p85 chimera by 18 degrees C. This modification appears to relieve an unfavorable surface electrostatic interaction, demonstrating the importance of surface charge interactions in protein stability.	Arginine	32-40	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	155-158
26858254-4	2016	In the yeastSaccharomyces cerevisiae, the separase-mediated cleavage of the Scc1/Rad21/Mcd1 cohesin subunit generates a C-terminal fragment that bears N-terminal Arg and is destroyed by the N-end rule pathway without a requirement for arginylation.	Arginine	162-165	RAD21 cohesin complex component	Mus musculus	76-80
12493833-2	2003	The AK specifically catalyzes the reversible phosphoryl transfer between ATP and arginine.	Arginine	81-89	arginine kinase	Limulus polyphemus	4-6
26858254-4	2016	In the yeastSaccharomyces cerevisiae, the separase-mediated cleavage of the Scc1/Rad21/Mcd1 cohesin subunit generates a C-terminal fragment that bears N-terminal Arg and is destroyed by the N-end rule pathway without a requirement for arginylation.	Arginine	162-165	RAD21 cohesin complex component	Mus musculus	81-86
26956095-5	2016	These integrins are known to specifically interact with vitronectin and collagen-IV, respectively, through binding to an Arg-Gly-Asp (RGD) sequence.	Arginine	121-124	vitronectin	Homo sapiens	56-67
26728248-5	2016	We also show that LC3 is enriched in nucleoli and its triple arginine motif is especially important for nucleolar targeting.	Arginine	61-69	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	18-21
27014078-2	2016	In human endothelium, cationic amino acid transporter 1 (hCAT-1) is related to the synthesis of nitric oxide (NO) and insulin has a vascular effect in endothelial cells through a signaling pathway that involves increases in hCAT-1 expression and L-arginine transport.	Arginine	246-256	solute carrier family 7 member 1	Homo sapiens	57-63
26573540-9	2016	This is of particular importance because hArg and GAA are produced from Arg by the catalytic action of arginine:glycine amidinotransferase (AGAT) also known as glycine:arginine transamidinase (GATM).	Arginine	42-45	glycine amidinotransferase	Homo sapiens	103-138
12542731-7	2003	C3a des arg levels increased during storage in all media with the exception of PASIII and, on day 7, were higher in PC stored in plasma compared to PC stored in the other media.	Arginine	8-11	complement C3	Homo sapiens	0-3
12501193-4	2002	However, the 85 kDa regulatory subunit (p85) of the phosphoinositide 3-kinase (PI-3K) is homologous with the Cdc42GAP and contains the essential arginine residue, but is ineffective as a GAP.	Arginine	145-153	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	40-43
12470634-6	2002	Finally, we show that Arg interacts with and phosphorylates Rad51 in 293T cells.	Arginine	22-25	RAD51 recombinase	Homo sapiens	60-65
12244096-6	2002	Furthermore, we find that either of the two arginine/glycine-rich domains of GAR1 can provide for interaction with SMN, but removal of both results in loss of the interaction.	Arginine	44-52	GAR1 ribonucleoprotein	Homo sapiens	77-81
12270926-7	2002	TRH-[Gly(4)-Lys(5)-Arg(6)] and TRH-[Gly(4)-Lys(5)] represent approximately 45% of the total TRH-like immunoreactivity in Cpe(fat/fat) mice; they constitute approximately 1% in controls.	Arginine	19-22	thyrotropin releasing hormone	Mus musculus	0-3
12490409-7	2002	L-Arg supplementation also inhibited the spontaneous EBV reactivation in another BL cell line EB1 and a B lymphoblastoid cell line OB.	Arginine	0-5	microtubule associated protein RP/EB family member 1	Homo sapiens	94-97
26573540-9	2016	This is of particular importance because hArg and GAA are produced from Arg by the catalytic action of arginine:glycine amidinotransferase (AGAT) also known as glycine:arginine transamidinase (GATM).	Arginine	42-45	glycine amidinotransferase	Homo sapiens	140-144
26573540-9	2016	This is of particular importance because hArg and GAA are produced from Arg by the catalytic action of arginine:glycine amidinotransferase (AGAT) also known as glycine:arginine transamidinase (GATM).	Arginine	42-45	glycine amidinotransferase	Homo sapiens	160-191
26573540-9	2016	This is of particular importance because hArg and GAA are produced from Arg by the catalytic action of arginine:glycine amidinotransferase (AGAT) also known as glycine:arginine transamidinase (GATM).	Arginine	42-45	glycine amidinotransferase	Homo sapiens	193-197
26865023-2	2016	Arginine uptake mainly occurs through three amino acid permeases, Alp1p, Gap1p and Can1p, which act as both transporters and receptors for amino acid utilization.	Arginine	0-8	arginine permease ALP1	Saccharomyces cerevisiae S288C	66-71
26865023-2	2016	Arginine uptake mainly occurs through three amino acid permeases, Alp1p, Gap1p and Can1p, which act as both transporters and receptors for amino acid utilization.	Arginine	0-8	arginine permease CAN1	Saccharomyces cerevisiae S288C	83-88
26865023-7	2016	Meanwhile, overexpression of Alp1p and Can1p enhanced growth and arginine utilization in WT, Deltaalp1Deltagap1Deltacan1 and Deltanpr1.	Arginine	65-73	arginine permease ALP1	Saccharomyces cerevisiae S288C	29-34
26865023-7	2016	Meanwhile, overexpression of Alp1p and Can1p enhanced growth and arginine utilization in WT, Deltaalp1Deltagap1Deltacan1 and Deltanpr1.	Arginine	65-73	arginine permease CAN1	Saccharomyces cerevisiae S288C	39-44
26865023-8	2016	Besides, overexpression of Can1p caused a 26.7% increase in OD600 and 29.3% increase in arginine utilization compared to that of Alp1p in Deltaalp1Deltagap1Deltacan1.	Arginine	88-96	arginine permease CAN1	Saccharomyces cerevisiae S288C	27-32
26862216-1	2016	Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein-protein interactions (PPIs).	Arginine	48-51	inositol polyphosphate multikinase	Homo sapiens	0-34
26862216-1	2016	Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide kinase with unusually flexible substrate specificity and the capacity to partake in many functional protein-protein interactions (PPIs).	Arginine	48-51	inositol polyphosphate multikinase	Homo sapiens	36-40
26314333-3	2016	The missense mutation changes arginine 441 that is located in the centre of the WW domains into glutamine (R441Q), which potentially affects the function of the WWP1 protein.	Arginine	30-38	WW domain containing E3 ubiquitin protein ligase 1	Gallus gallus	161-165
26869767-7	2016	Using a combination of experimental and theoretical modeling analysis, we found that XN can embed into the hydrophobic pocket of MD-2 and form two stable hydrogen bonds with residues ARG-90 and TYR-102 of MD-2.	Arginine	183-186	lymphocyte antigen 96	Homo sapiens	205-209
26869767-8	2016	Moreover, we confirmed that ARG-90 and TYR-102 were two necessary residues during the recognition process of XN binding to MD-2.	Arginine	28-31	lymphocyte antigen 96	Homo sapiens	123-127
26601957-9	2016	These data provide new evidence demonstrating that amino acid sequence Leu(480)-Gln(481): 1) is crucial for proper recognition of the fVa-dependent site(s) for fXa within prothrombinase on FII, required for efficient initial cleavage of FII at Arg(320); and 2) is compulsory for appropriate tethering of fV, fVIII, and protein C required for their timely activation by IIa.	Arginine	244-247	coagulation factor X	Homo sapiens	160-163
26601957-9	2016	These data provide new evidence demonstrating that amino acid sequence Leu(480)-Gln(481): 1) is crucial for proper recognition of the fVa-dependent site(s) for fXa within prothrombinase on FII, required for efficient initial cleavage of FII at Arg(320); and 2) is compulsory for appropriate tethering of fV, fVIII, and protein C required for their timely activation by IIa.	Arginine	244-247	coagulation factor X	Homo sapiens	171-185
26449889-5	2016	Both naive and memory CD4(+) T cells as well as CD8(+) T cells specifically upregulated the human cationic amino acid transporter-1 (hCAT-1), with an enhanced and persistent expression under arginine starvation.	Arginine	191-199	CD8a molecule	Homo sapiens	48-51
26449889-5	2016	Both naive and memory CD4(+) T cells as well as CD8(+) T cells specifically upregulated the human cationic amino acid transporter-1 (hCAT-1), with an enhanced and persistent expression under arginine starvation.	Arginine	191-199	solute carrier family 7 member 1	Homo sapiens	133-139
26449889-6	2016	When hCAT-1 induction was suppressed via siRNA transfection, arginine uptake, and cellular proliferation were impaired.	Arginine	61-69	solute carrier family 7 member 1	Homo sapiens	5-11
26381755-8	2016	Biochemical analysis confirmed that arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1.	Arginine	36-44	protein arginine methyltransferase 1	Homo sapiens	112-117
27110069-5	2016	The results showed that arginine reduced the LPS-induced production like IL-1beta, IL-6, TNF-alpha, and iNOS.	Arginine	24-32	nitric oxide synthase 2	Bos taurus	104-108
26602113-2	2016	Arginine is methylated through the activity of protein arginine methyltransferases (PRMT1 and PRMT2), to form asymmetrical dimethylarginine (ADMA) and symmetrical dimethylarginine (SDMA).	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	84-89
26602113-2	2016	Arginine is methylated through the activity of protein arginine methyltransferases (PRMT1 and PRMT2), to form asymmetrical dimethylarginine (ADMA) and symmetrical dimethylarginine (SDMA).	Arginine	0-8	protein arginine methyltransferase 2	Homo sapiens	94-99
26437261-2	2015	To overcome these obstacles and achieve cancer-specific targeting, we constructed tumor targeting bioreducible polymer, an arginine grafted bio-reducible polymer (ABP)-PEG-HCBP1, by conjugating PEGylated ABP with HCBP1 peptides which has high affinity and selectivity towards hepatoma.	Arginine	123-131	aminoacylase 3	Homo sapiens	172-177
26437261-2	2015	To overcome these obstacles and achieve cancer-specific targeting, we constructed tumor targeting bioreducible polymer, an arginine grafted bio-reducible polymer (ABP)-PEG-HCBP1, by conjugating PEGylated ABP with HCBP1 peptides which has high affinity and selectivity towards hepatoma.	Arginine	123-131	aminoacylase 3	Homo sapiens	213-218
26562193-8	2015	XRCC1 Arg/Gln+Gln/Gln genotype increased the risk of MS.	Arginine	6-9	X-ray repair cross complementing 1	Homo sapiens	0-5
26071206-13	2015	In a South Indian population, the ADRB2 Arg/Gly may not form a susceptible variant to develop asthma nor can be a standard predictive marker to bronchodilator response; nevertheless, the patterns in asthma severity can be predicted by analyzing this variant.	Arginine	40-43	adrenoceptor beta 2	Homo sapiens	34-39
26537638-1	2015	Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine.	Arginine	141-151	arginase 2	Homo sapiens	15-25
26283331-3	2015	We discovered that compared to the initial infection isolate, the strain recovered during asymptomatic carriage contained three single nucleotide polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor kinase, liaS, resulting in an arginine-to-glycine amino acid replacement at position 135 of LiaS (LiaS(R135G)).	Arginine	265-273	lipoic acid synthetase	Mus musculus	243-247
26283331-3	2015	We discovered that compared to the initial infection isolate, the strain recovered during asymptomatic carriage contained three single nucleotide polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor kinase, liaS, resulting in an arginine-to-glycine amino acid replacement at position 135 of LiaS (LiaS(R135G)).	Arginine	265-273	lipoic acid synthetase	Mus musculus	327-331
26283331-3	2015	We discovered that compared to the initial infection isolate, the strain recovered during asymptomatic carriage contained three single nucleotide polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor kinase, liaS, resulting in an arginine-to-glycine amino acid replacement at position 135 of LiaS (LiaS(R135G)).	Arginine	265-273	lipoic acid synthetase	Mus musculus	333-337
26400692-5	2015	A linear analog of HD6, in which the distribution of arginine residues was similar to active alpha-defensins, shows broad-spectrum antimicrobial activity, indicating that atypical distribution of arginine residues contributes to the inactivity of HD6.	Arginine	53-61	defensin alpha 6	Homo sapiens	19-22
26400692-5	2015	A linear analog of HD6, in which the distribution of arginine residues was similar to active alpha-defensins, shows broad-spectrum antimicrobial activity, indicating that atypical distribution of arginine residues contributes to the inactivity of HD6.	Arginine	196-204	defensin alpha 6	Homo sapiens	19-22
26316623-5	2015	This phenotype was caused by a FLI1 homozygous c.970C&gt;T-point mutation that predicts an arginine-to-tryptophan substitution in the conserved ETS DNA-binding domain of FLI1.	Arginine	91-99	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	31-35
26436293-3	2015	Through analysis of the NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in NCOA4 is required for delivery of ferritin to the lysosome via autophagosomes.	Arginine	105-113	ferritin, heavy polypeptide 1a	Danio rerio	30-34
26436293-3	2015	Through analysis of the NCOA4-FTH1 interaction, we demonstrate that direct association via a key surface arginine in FTH1 and a C-terminal element in NCOA4 is required for delivery of ferritin to the lysosome via autophagosomes.	Arginine	105-113	ferritin, heavy polypeptide 1a	Danio rerio	117-121
26283571-0	2015	CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of L-Arg via a NO-independent mechanism.	Arginine	93-98	solute carrier family 7 member 1	Homo sapiens	0-5
26283571-7	2015	Further functional characterization has disclosed that extracellular L-Arg exposure stabilizes endothelial integrity via abating the cell junction disassembly of CAT-1 and blocking the cellular membrane CAT-1 internalization, which provides the new mechanisms for L-Arg paradox and trans-stimulation of cationic amino acid transport system (CAAT).	Arginine	69-74	solute carrier family 7 member 1	Homo sapiens	162-167
26283571-7	2015	Further functional characterization has disclosed that extracellular L-Arg exposure stabilizes endothelial integrity via abating the cell junction disassembly of CAT-1 and blocking the cellular membrane CAT-1 internalization, which provides the new mechanisms for L-Arg paradox and trans-stimulation of cationic amino acid transport system (CAAT).	Arginine	69-74	solute carrier family 7 member 1	Homo sapiens	203-208
12388162-1	2002	Administration of arginine or a high-protein diet increases the hepatic content of N-acetylglutamate (NAG) and the synthesis of urea.	Arginine	18-26	NBAS subunit of NRZ tethering complex	Homo sapiens	83-106
26622834-4	2015	Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues.	Arginine	25-33	protein arginine methyltransferase 1	Homo sapiens	70-75
12388162-3	2002	We have explored the hypothesis that agmatine, a metabolite of arginine, may stimulate NAG synthesis and, thereby, urea synthesis.	Arginine	63-71	NBAS subunit of NRZ tethering complex	Homo sapiens	87-90
26622834-4	2015	Furthermore, the protein arginine methyltransferases (PRMTs), such as PRMT1, PRMT4 and PRMT6, were determined to be involved in the methylation of the p16 arginine residues.	Arginine	25-33	coactivator associated arginine methyltransferase 1	Homo sapiens	77-82
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Arginine	36-39	CD47 molecule	Homo sapiens	116-203
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Arginine	36-39	CD47 molecule	Homo sapiens	205-208
25989232-6	2015	The synthesis of NO by the endothelium is critically dependent on the plasmalemmal transport of its substrate, L-arginine, via the cationic amino acid transporter-1 (CAT1).	Arginine	111-121	solute carrier family 7 member 1	Homo sapiens	131-164
12464013-2	2002	Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding.	Arginine	36-39	CD47 molecule	Homo sapiens	210-214
12470967-9	2002	In conclusion, AS and arginase I are coinduced with iNOS in infiltrated inflammatory cells in the eyes of EIU rats, and may regulate NO production by changing intracellular concentration of arginine.	Arginine	190-198	argininosuccinate synthase 1	Rattus norvegicus	15-17
25989232-6	2015	The synthesis of NO by the endothelium is critically dependent on the plasmalemmal transport of its substrate, L-arginine, via the cationic amino acid transporter-1 (CAT1).	Arginine	111-121	solute carrier family 7 member 1	Homo sapiens	166-170
26420673-0	2015	Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	68-72
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	Arginine	45-53	azurocidin 1	Homo sapiens	3-8
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	42-46
12446179-1	2002	Neuronal nitric oxide synthase (nNOS) catalyzes the synthesis of neuronal nitric oxide from L-arginine.	Arginine	92-102	nitric oxide synthase 1	Rattus norvegicus	0-30
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	65-69
12446179-1	2002	Neuronal nitric oxide synthase (nNOS) catalyzes the synthesis of neuronal nitric oxide from L-arginine.	Arginine	92-102	nitric oxide synthase 1	Rattus norvegicus	32-36
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	65-69
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	65-69
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	65-69
12445581-1	2002	The aim of this study was to investigate in rat gastric fundus whether L-citrulline, the co-product in the nitric oxide (NO) biosynthesis catalyzed by neuronal nitric oxide synthase (nNOS), can be converted back to the nNOS substrate L-arginine.	Arginine	234-244	nitric oxide synthase 1	Rattus norvegicus	151-181
12445581-1	2002	The aim of this study was to investigate in rat gastric fundus whether L-citrulline, the co-product in the nitric oxide (NO) biosynthesis catalyzed by neuronal nitric oxide synthase (nNOS), can be converted back to the nNOS substrate L-arginine.	Arginine	234-244	nitric oxide synthase 1	Rattus norvegicus	183-187
12445581-2	2002	Immunohistochemistry showed that argininosuccinate synthetase and argininosuccinate lyase, that mediate transformation of L-citrulline to L-arginine in the ureum cycle in hepatocytes, co-localize with nNOS.	Arginine	138-148	nitric oxide synthase 1	Rattus norvegicus	201-205
26420673-3	2015	Here we show that arginine methylation of KLF4 by PRMT5 inhibits KLF4 ubiquitylation by VHL and thereby reduces KLF4 turnover, resulting in the elevation of KLF4 protein levels concomitant with increased transcription of KLF4-dependent p21 and reduced expression of KLF4-repressed Bax.	Arginine	18-26	Kruppel like factor 4	Homo sapiens	65-69
26078354-0	2015	Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3.	Arginine	18-26	fibroblast growth factor receptor 3	Homo sapiens	129-134
26078354-11	2015	Collectively, our findings provide new evidence that PRMT5 plays an important role in CRC pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E and FGFR3.	Arginine	137-145	fibroblast growth factor receptor 3	Homo sapiens	189-194
12239211-8	2002	Induction of HSP42 by AZC treatment required protein synthesis; treatment with ethanol, which can also misfold proteins, activated heat shock factor, but treatment with canavanine, an arginine analog less potent than AZC at misfolding proteins, did not.	Arginine	184-192	heat shock protein HSP42	Saccharomyces cerevisiae S288C	13-18
26221041-8	2015	Reversible arginine methylation of TRAF6 by the opposing effects of PRMT1 and JMJD6 is, therefore, a novel mechanism for regulation of innate immune pathways.	Arginine	11-19	protein arginine methyltransferase 1	Homo sapiens	68-73
26031828-17	2015	In mice, GAMT and N (G)-methyltransferases contribute to ADMA and hArg synthesis from Arg, whereas AGAT is involved in the synthesis of hArg but not of ADMA.	Arginine	67-70	guanidinoacetate methyltransferase	Mus musculus	9-13
12371970-0	2002	L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.	Arginine	0-10	solute carrier family 7 member 2	Rattus norvegicus	67-72
12924019-5	2002	Both 10(-2) M 6-aminohexanoic acid and 10(-1) M arginine reduced the complex formation rate between plasmin, mini-plasmin and alpha 2-antiplasmin to the value of the rate reaction between micro-plasmin and inhibitor.	Arginine	48-56	serpin family F member 2	Homo sapiens	126-145
26123985-7	2015	hArg is a non-essential, non-proteinogenic amino acid which is synthesized from Arg by arginine:glycine amidinotransferase (AGAT).	Arginine	1-4	glycine amidinotransferase	Homo sapiens	87-122
26303972-6	2015	The amino-terminal Arg of BiP binds p62, which triggers p62 oligomerization and enhances p62-LC3 interaction, thereby stimulating autophagic delivery and degradation of misfolded proteins, promoting cell survival.	Arginine	19-22	nucleoporin 62	Homo sapiens	36-39
12176998-0	2002	Network of interactions of a novel plant-specific Arg/Ser-rich protein, atRSZ33, with atSC35-like splicing factors.	Arginine	50-53	arginine/serine-rich zinc knuckle-containing protein 33	Arabidopsis thaliana	72-79
12176998-0	2002	Network of interactions of a novel plant-specific Arg/Ser-rich protein, atRSZ33, with atSC35-like splicing factors.	Arginine	50-53	serine/arginine-rich splicing factor-like protein, putative	Arabidopsis thaliana	86-92
12374740-3	2002	Here, we discover a pocket in the kinase domain of PDK1 that recognizes the phosphoserine/phosphothreonine in the hydrophobic motif by identifying two oppositely positioned arginine and lysine residues that bind the phosphate.	Arginine	173-181	pyruvate dehydrogenase kinase 1	Homo sapiens	51-55
12374746-6	2002	Here, we report that another domain of CBP is specifically methylated by CARM1 on conserved arginine residues in vitro and in vivo.	Arginine	92-100	coactivator associated arginine methyltransferase 1	Homo sapiens	73-78
26303972-6	2015	The amino-terminal Arg of BiP binds p62, which triggers p62 oligomerization and enhances p62-LC3 interaction, thereby stimulating autophagic delivery and degradation of misfolded proteins, promoting cell survival.	Arginine	19-22	nucleoporin 62	Homo sapiens	56-59
26303972-6	2015	The amino-terminal Arg of BiP binds p62, which triggers p62 oligomerization and enhances p62-LC3 interaction, thereby stimulating autophagic delivery and degradation of misfolded proteins, promoting cell survival.	Arginine	19-22	nucleoporin 62	Homo sapiens	56-59
12372405-8	2002	The short NPF receptor was not activated by any of the other tested arthropod peptides, not even by FMRFamide-related peptides (also ending in RFamide), indicating that the Arg residue at position 4 from the amidated C-terminus appears to be crucial for the response elicited by the sNPFs.	Arginine	173-176	Neuropeptide F receptor	Drosophila melanogaster	10-22
26062636-0	2015	Estradiol augments while progesterone inhibits arginine transport in human endothelial cells through modulation of cationic amino acid transporter-1.	Arginine	47-55	solute carrier family 7 member 1	Homo sapiens	115-148
12356818-8	2002	A candidate gene, connexin 50 (Cx50/Gja8), had a C-to-T transition at codon 340 that is predicted to result in a nonconservative substitution of arginine by tryptophan.	Arginine	145-153	gap junction protein, alpha 8	Rattus norvegicus	18-29
26062636-2	2015	Delivery of arginine to eNOS by cationic amino acid transporter-1 (CAT-1) was shown to modulate eNOS activity.	Arginine	12-20	solute carrier family 7 member 1	Homo sapiens	32-65
12356818-8	2002	A candidate gene, connexin 50 (Cx50/Gja8), had a C-to-T transition at codon 340 that is predicted to result in a nonconservative substitution of arginine by tryptophan.	Arginine	145-153	gap junction protein, alpha 8	Rattus norvegicus	31-35
26062636-2	2015	Delivery of arginine to eNOS by cationic amino acid transporter-1 (CAT-1) was shown to modulate eNOS activity.	Arginine	12-20	solute carrier family 7 member 1	Homo sapiens	67-72
12356818-8	2002	A candidate gene, connexin 50 (Cx50/Gja8), had a C-to-T transition at codon 340 that is predicted to result in a nonconservative substitution of arginine by tryptophan.	Arginine	145-153	gap junction protein, alpha 8	Rattus norvegicus	36-40
26300654-9	2015	L-Arginine is substrate of nitric oxide synthase, and L-arginine is depleted during the production of nitric oxide, which may activate EIF2AK4 to inhibit protein synthesis and negatively regulate vasculogenesis.	Arginine	0-10	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	135-142
12370279-4	2002	Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release.	Arginine	176-184	insulin like growth factor 1 receptor	Homo sapiens	33-38
12237227-1	2002	We are combining stopped-flow, stop-quench, and rapid-freezing kinetic methods to help clarify the unique redox roles of tetrahydrobiopterin (H(4)B) in NO synthesis, which occurs via the consecutive oxidation of L-arginine (Arg) and N-hydroxy-L-arginine (NOHA).	Arginine	212-222	H4 clustered histone 4	Homo sapiens	142-147
12237227-1	2002	We are combining stopped-flow, stop-quench, and rapid-freezing kinetic methods to help clarify the unique redox roles of tetrahydrobiopterin (H(4)B) in NO synthesis, which occurs via the consecutive oxidation of L-arginine (Arg) and N-hydroxy-L-arginine (NOHA).	Arginine	224-227	H4 clustered histone 4	Homo sapiens	142-147
12237227-2	2002	In the Arg reaction, H(4)B radical formation is coupled to reduction of a heme Fe(II)O(2) intermediate.	Arginine	7-10	H4 clustered histone 4	Homo sapiens	21-26
26300654-9	2015	L-Arginine is substrate of nitric oxide synthase, and L-arginine is depleted during the production of nitric oxide, which may activate EIF2AK4 to inhibit protein synthesis and negatively regulate vasculogenesis.	Arginine	54-64	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	135-142
12237227-4	2002	Because H(4)B provides this electron faster than can the NOS reductase domain, H(4)B appears to be a kinetically preferred source of the second electron for oxygen activation during Arg hydroxylation.	Arginine	182-185	H4 clustered histone 4	Homo sapiens	8-13
12237227-4	2002	Because H(4)B provides this electron faster than can the NOS reductase domain, H(4)B appears to be a kinetically preferred source of the second electron for oxygen activation during Arg hydroxylation.	Arginine	182-185	H4 clustered histone 4	Homo sapiens	79-84
25960296-3	2015	GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin alpha subtypes (alpha1, alpha2 and alpha4).	Arginine	57-65	immunoglobulin binding protein 1	Homo sapiens	128-146
26185611-8	2015	The prevalence of mutant alleles of hOGG1 gene, XRCC1 gene (codon 280 Arg&gt;His) were found to be significantly higher among SCD patients as compared to controls.	Arginine	70-73	X-ray repair cross complementing 1	Homo sapiens	48-53
26557159-10	2015	In FGFR3 gene 10/TM location of 1172 the nucleotide changes C&gt;A, Ala 391 Glu 19/56 and Exon-19, 5q35.2 at conserved linker region the changes occurred pro 246 Arg in 25/56 families.	Arginine	162-165	fibroblast growth factor receptor 3	Homo sapiens	3-8
12200128-7	2002	Mutation of lysine 1086 of SALL1 to arginine abrogates SALL1 sumoylation, suggesting the presence of a polymeric SUMO-1 chain in the wild type state.	Arginine	36-44	spalt like transcription factor 1	Homo sapiens	27-32
12200128-7	2002	Mutation of lysine 1086 of SALL1 to arginine abrogates SALL1 sumoylation, suggesting the presence of a polymeric SUMO-1 chain in the wild type state.	Arginine	36-44	spalt like transcription factor 1	Homo sapiens	55-60
26075355-4	2015	R-BiP binds the autophagic adaptor p62 through the interaction of its N-terminal arginine with the p62 ZZ domain.	Arginine	81-89	sequestosome 1	Homo sapiens	35-38
12160895-8	2002	Among workers who had smoked equal to or greater than 10 cigarettes each day, those with XRCC1 Arg/Gln+Gln/Gln had higher SCE frequency than those with XRCC1 Arg/Arg after adjusting for potential confounders (9.0 versus 7.9, P&lt;0.05).	Arginine	95-98	X-ray repair cross complementing 1	Homo sapiens	89-94
26080448-0	2015	Arginine methylation of HSP70 regulates retinoid acid-mediated RARbeta2 gene activation.	Arginine	0-8	heat shock protein family A (Hsp70) member 4	Homo sapiens	24-29
12186556-7	2002	Mutation of the catalytic cysteine (Cys-215 in PTP1B) into alanine had no effect on the cross-peaks, whereas mutation of a conserved active-site arginine (Arg-221 in PTP1B) to alanine abolished all three cross-peaks.	Arginine	145-153	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	166-171
12186556-7	2002	Mutation of the catalytic cysteine (Cys-215 in PTP1B) into alanine had no effect on the cross-peaks, whereas mutation of a conserved active-site arginine (Arg-221 in PTP1B) to alanine abolished all three cross-peaks.	Arginine	155-158	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	166-171
26309678-7	2015	Compared Arg/Arg genotype, the risk of cisplatin resistance in patients with Arp/Trp genotype of XRCC1 gene was increased by 6.701 times (95% CI: 1.464~30.732, P&lt;0.05).	Arginine	9-12	X-ray repair cross complementing 1	Homo sapiens	97-102
12063246-2	2002	The specificity constant for the phosphorylation of GST-Pyk1 and GST-Pyk2 by bovine catalytic subunit was in the range of the value for Leu-Arg-Arg-Ala-Ser-Leu-Gly (Kemptide).	Arginine	140-143	protein tyrosine kinase 2 beta	Bos taurus	69-73
26309678-7	2015	Compared Arg/Arg genotype, the risk of cisplatin resistance in patients with Arp/Trp genotype of XRCC1 gene was increased by 6.701 times (95% CI: 1.464~30.732, P&lt;0.05).	Arginine	13-16	X-ray repair cross complementing 1	Homo sapiens	97-102
25948817-6	2015	Strikingly, both tetramer(+)/TRBV9(+) and tetramer(+)/TRBV9(-) T cells possessed a non-germline-encoded arginine residue in their CDR3alpha and CDR3beta loops, respectively.	Arginine	104-112	T cell receptor beta variable 9	Homo sapiens	29-34
12058042-8	2002	Furthermore, peroxynitrite stimulation of L-arginine release was abolished in fibroblast cells homozygous for a targeted inactivation of the Cat1 gene.	Arginine	42-52	transient receptor potential cation channel subfamily V member 6	Homo sapiens	141-145
12058042-10	2002	These results strongly suggest that peroxynitrite-mediated activation of the Cat1 transporter in glial cells may serve as a mechanism focused to replenish L-arginine in the neighboring neurons.	Arginine	155-165	transient receptor potential cation channel subfamily V member 6	Homo sapiens	77-81
25948817-6	2015	Strikingly, both tetramer(+)/TRBV9(+) and tetramer(+)/TRBV9(-) T cells possessed a non-germline-encoded arginine residue in their CDR3alpha and CDR3beta loops, respectively.	Arginine	104-112	T cell receptor beta variable 9	Homo sapiens	54-59
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	T cell receptor beta variable 9	Homo sapiens	46-51
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	T cell receptor beta variable 9	Homo sapiens	66-71
12138176-9	2002	Substitution of arginine residues within this motif abolished S1P cleavage, providing robust evidence that S1P is involved in Luman processing.	Arginine	16-24	membrane bound transcription factor peptidase, site 1	Homo sapiens	62-65
12138176-9	2002	Substitution of arginine residues within this motif abolished S1P cleavage, providing robust evidence that S1P is involved in Luman processing.	Arginine	16-24	membrane bound transcription factor peptidase, site 1	Homo sapiens	107-110
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	T cell receptor beta variable 9	Homo sapiens	66-71
12138185-1	2002	Arg80 and Mcm1, two members of the MADS box family of DNA-binding proteins, regulate the metabolism of arginine in association with Arg81, the arginine sensor.	Arginine	103-111	serum response factor	Homo sapiens	10-14
25948817-7	2015	Comparison of the crystal structures of three TRBV9(+) TCRs and a TRBV9(-) TCR revealed that, as a result of distinct TCR docking modes, the HLA-DQ8-glia-alpha1 contacts mediated by the CDR3-encoded arginine were almost identical between TRBV9(+) and TRBV9(-) TCRs.	Arginine	199-207	T cell receptor beta variable 9	Homo sapiens	66-71
12138185-1	2002	Arg80 and Mcm1, two members of the MADS box family of DNA-binding proteins, regulate the metabolism of arginine in association with Arg81, the arginine sensor.	Arginine	143-151	serum response factor	Homo sapiens	10-14
25809937-6	2015	Targeted exome sequencing, conducted using DNA samples of an affected member in this family, revealed a novel heterozygous missense mutation c.1643C&gt;G in exon 18 of EYA4, causing amino-acid (aa) substitution Arg for Thr at a conserved position aa-548.	Arginine	211-214	EYA transcriptional coactivator and phosphatase 4	Homo sapiens	168-172
12202230-6	2002	Moreover, replacement of lysine by arginine in the basic domains decreases the trans-activating capacity of CREB-2.	Arginine	35-43	activating transcription factor 4	Homo sapiens	108-114
12082127-4	2002	It has been proposed that this species specificity of the hGHR is largely caused by the Leu --&gt; Arg change at position 43 after a prior His --&gt; Asp change at position 171 of the GH.	Arginine	99-102	growth hormone receptor	Homo sapiens	58-62
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	67-75	protein arginine methyltransferase 1	Homo sapiens	29-34
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	80-83	protein arginine methyltransferase 1	Homo sapiens	29-34
12082127-8	2002	Also, if the emergence of species specificity was a result of the selection for a more efficient GH:GHR interaction, then changing residue 43 of the squirrel monkey growth hormone receptor (smGHR) to Arg should increase its binding affinity toward higher primate GH.	Arginine	200-203	growth hormone receptor	Homo sapiens	100-103
25847239-5	2015	Taken together, we show that PRMT1 is a novel regulator of EMT and arginine 34 (Arg-34) methylation of Twist1 as a unique "methyl arginine mark" for active E-cadherin repression.	Arginine	130-138	protein arginine methyltransferase 1	Homo sapiens	29-34
12082127-8	2002	Also, if the emergence of species specificity was a result of the selection for a more efficient GH:GHR interaction, then changing residue 43 of the squirrel monkey growth hormone receptor (smGHR) to Arg should increase its binding affinity toward higher primate GH.	Arginine	200-203	growth hormone receptor	Homo sapiens	165-188
25795782-4	2015	This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4/VAV1/RAC1 NADPH oxidase complex.	Arginine	37-40	Rac family small GTPase 1	Homo sapiens	109-113
12027455-7	2002	The C-terminus responsible for nuclear speckle localization of RH-II/Gu(beta) contains an arginine-serine-rich domain present in some RNA splicing proteins.	Arginine	90-98	DExD-box helicase 21	Homo sapiens	63-71
25795782-5	2015	Arg-395 stabilizes the C-terminal tail of NCF4 and the conformation of NCF2 loop 395-402, which in turn stabilize the evolutionarily conserved interactions of NCF2/NCF4 with the DH domain of VAV1 and RAC1 region 120-137.	Arginine	0-3	Rac family small GTPase 1	Homo sapiens	200-204
25946048-4	2015	Here we show that Abl family of non-receptor tyrosine kinases, comprised of Abl (ABL1) and Arg (ABL2), are activated downstream of the Met receptor, and that inhibition of Abl kinases dramatically suppresses HGF-induced cell scattering and tubulogenesis.	Arginine	91-94	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-21
25772617-10	2015	We also found that cytosolic sequences of other LAMP family proteins, LAMP1 and CD68/LAMP4, also possess arginine residues, and show affinity for nucleic acids.	Arginine	105-113	CD68 molecule	Homo sapiens	80-84
12044168-7	2002	The helices (Vpu(6-33)) are extended to include hydrophilic residues such as Glu, Tyr, and Arg (EYR motif).	Arginine	91-94	Vpu	Human immunodeficiency virus 1	13-16
25772617-10	2015	We also found that cytosolic sequences of other LAMP family proteins, LAMP1 and CD68/LAMP4, also possess arginine residues, and show affinity for nucleic acids.	Arginine	105-113	CD68 molecule	Homo sapiens	85-90
25909858-9	2015	Complementation of the yeast npr1Delta mutant with each of the three F. fujikuroi NPR1 homologues, resulted in partial restoration of ammonium, arginine and proline uptake by FfNPR1-1 while none of the three kinases affect growth on different nitrogen sources and nitrogen-dependent sorting of FfGap1 in F. fujikuroi.	Arginine	144-152	serine/threonine protein kinase NPR1	Saccharomyces cerevisiae S288C	82-86
12119107-1	2002	Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates.	Arginine	82-85	arginyl aminopeptidase	Homo sapiens	0-16
12119107-1	2002	Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates.	Arginine	82-85	arginyl aminopeptidase	Homo sapiens	18-21
12052181-4	2002	The TAR-Tat interaction of HIV-1 has the interesting feature that both Tat and arginine are able to bind to and bring about comparable conformational changes in the TAR loop.	Arginine	79-87	Tat	Human immunodeficiency virus 1	8-11
25621824-2	2015	PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine residues at ER binding sites.	Arginine	118-126	peptidyl arginine deiminase 2	Homo sapiens	0-4
22905391-3	2002	Rats pre-treated with coconut protein or L-arginine showed significantly decreased CPK, GOT and GPT activities in the serum.	Arginine	41-51	glutamic--pyruvic transaminase	Rattus norvegicus	96-99
25866881-7	2015	Changing the lysines at positions 73, 78, and 85 to arginines suppressed the ubiquitination of A/Puerto Rico/8/1934 (H1N1)-derived PB1-F2.	Arginine	52-61	submaxillary gland androgen regulated protein 3A	Homo sapiens	131-134
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	63-66	coagulation factor X	Homo sapiens	22-31
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	63-66	coagulation factor X	Homo sapiens	33-36
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	63-66	coagulation factor X	Homo sapiens	153-156
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	22-31
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	33-36
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	153-156
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	22-31
24728914-2	2015	We examined the concept that expression levels of endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil integrins Mac-1 and LFA-1 are modulated by the kinin B1 receptor (B1R) agonist, Lys-des[Arg(9)]bradykinin (LDBK).	Arginine	208-211	intercellular adhesion molecule 1	Homo sapiens	62-95
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	33-36
12022882-1	2002	The autolysis loop of factor Xa (fXa) has four basic residues (Arg(143), Lys(147), Arg(150), and Arg(154)) whose contribution to protease specificity of fXa has not been examined.	Arginine	83-86	coagulation factor X	Homo sapiens	153-156
12009884-0	2002	Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.	Arginine	144-152	carbonic anhydrase 1	Homo sapiens	55-75
12009884-0	2002	Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.	Arginine	144-152	carbonic anhydrase 1	Homo sapiens	77-81
24728914-2	2015	We examined the concept that expression levels of endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil integrins Mac-1 and LFA-1 are modulated by the kinin B1 receptor (B1R) agonist, Lys-des[Arg(9)]bradykinin (LDBK).	Arginine	208-211	intercellular adhesion molecule 1	Homo sapiens	97-103
24728914-2	2015	We examined the concept that expression levels of endothelial intercellular adhesion molecule-1 (ICAM-1) and neutrophil integrins Mac-1 and LFA-1 are modulated by the kinin B1 receptor (B1R) agonist, Lys-des[Arg(9)]bradykinin (LDBK).	Arginine	208-211	integrin subunit alpha M	Homo sapiens	130-135
25673704-0	2015	A triple-arginine motif in the amino-terminal domain and oligomerization are required for HIV-1 inhibition by human MX2.	Arginine	9-17	MX dynamin like GTPase 2	Homo sapiens	116-119
11994446-0	2002	Priming Th1 immunity to viral core particles is facilitated by trace amounts of RNA bound to its arginine-rich domain.	Arginine	97-105	negative elongation factor complex member C/D	Homo sapiens	8-11
11994446-11	2002	Hence, codelivery of an efficient, intrinsic adjuvant (i.e., nanogram amounts of prokaryotic or eukaryotic RNA bound to arginine-rich sequences) by HBcAg nucleocapsids facilitates priming of anti-viral Th1 immunity.	Arginine	120-128	negative elongation factor complex member C/D	Homo sapiens	202-205
26170816-9	2015	In case of MMP-2, Leu 164, Ala 165 and Thr 227 were engaged in H-Bonding with resveratrol and in case of MMP-9, H-bonding was found with Glu 402, Ala 417 and Arg 424 residues.	Arginine	158-161	matrix metallopeptidase 9	Homo sapiens	105-110
12062473-8	2002	The IC(50) values of TRH-like peptides for displacement of [3H]TRH from TRHR2 were TRH&lt;&lt;&lt;(Leu(2)-, Phe(2)-TRH)&lt;(Gln(2)-, Ser(2)-TRH)&lt;&lt;(Val(2)-, Tyr(2)-, Arg(2)-, Thr(2)-, and Glu(2)-TRH).	Arginine	171-174	motilin receptor	Rattus norvegicus	72-77
25694433-2	2015	beta1 integrins signal through the Abl2/Arg (Abl-related gene) nonreceptor tyrosine kinase to control fibroblast cell motility, neuronal dendrite morphogenesis and stability, and cancer cell invasiveness, but the molecular mechanisms by which integrin beta1 activates Arg are unknown.	Arginine	40-43	integrin subunit beta 1	Homo sapiens	243-257
11827963-4	2002	Two important amino acid residues (Asn(263) in sensor 1 and Arg(332) in sensor 2) were identified as key residues for Cdc6p function in vivo.	Arginine	60-63	AAA family ATPase CDC6	Saccharomyces cerevisiae S288C	118-123
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Arginine	24-27	integrin subunit beta 1	Homo sapiens	113-127
25694433-3	2015	We report here that the Arg kinase domain interacts directly with a lysine-rich membrane-proximal segment in the integrin beta1 cytoplasmic tail, that Arg phosphorylates the membrane-proximal Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated region in the tail.	Arginine	151-154	integrin subunit beta 1	Homo sapiens	113-127
11854277-7	2002	A single nucleotide polymorphism was identified that involves a non-synonymous G --&gt; A transition at nucleotide 431 of the TSG-6 coding sequence, resulting in an Arg to Gln alteration in the CUB module (at residue 144 in the preprotein).	Arginine	165-168	TNF alpha induced protein 6	Homo sapiens	126-131
25694433-4	2015	We show that these interactions mediate direct binding between integrin beta1 and Arg in vitro and in cells and activate Arg kinase activity.	Arginine	82-85	integrin subunit beta 1	Homo sapiens	63-77
25517993-5	2015	Instead, two arginine residues, which presumably coordinate the arsenate substrate within the electrophilic binding site of GstB, were found to be critical for transferase activity.	Arginine	13-21	glutathione S-transferase mu 3	Homo sapiens	124-128
11937781-1	2002	A novel tetrapeptide derivative Boc-Lys(Boc)-Arg-Asp-Ser(tbu)-OtBu (PEP1261) has been tested in vivo in isoproterenol (ISO) hydrochloride (HCl)-induced myocardial necrosis in rats.	Arginine	45-48	BOC cell adhesion associated, oncogene regulated	Rattus norvegicus	32-35
11937781-1	2002	A novel tetrapeptide derivative Boc-Lys(Boc)-Arg-Asp-Ser(tbu)-OtBu (PEP1261) has been tested in vivo in isoproterenol (ISO) hydrochloride (HCl)-induced myocardial necrosis in rats.	Arginine	45-48	BOC cell adhesion associated, oncogene regulated	Rattus norvegicus	40-43
25772360-5	2015	C-terminal tail phosphorylation and PRMT5-catalyzed arginine methylation enhance nucleosome assembly by promoting histone interaction with the second acidic tract of Npm.	Arginine	52-60	protein arginine methyltransferase 5 L homeolog	Xenopus laevis	36-41
11969422-4	2002	Various types of mass spectrometry were used to analyze MLK3 tryptic peptides separated by C18 reverse-phase HPLC, leading to the identification of Ser(524), Ser(654), Ser(705), Ser(740), Ser(758), Ser(770), Ser(793), and a site found on peptide Ser(11)-Arg(37) within a Gly-rich region as MLK3 phosphorylation sites.	Arginine	254-257	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	56-60
25772360-5	2015	C-terminal tail phosphorylation and PRMT5-catalyzed arginine methylation enhance nucleosome assembly by promoting histone interaction with the second acidic tract of Npm.	Arginine	52-60	nucleophosmin (nucleolar phosphoprotein B23, numatrin) S homeolog	Xenopus laevis	166-169
25653279-2	2015	Arginine stimulates proliferation and interferon tau production by ovine trophectoderm cells via nitric oxide and polyamine-TSC2-MTOR signaling pathways.	Arginine	0-8	TSC complex subunit 2	Homo sapiens	124-128
26090102-10	2015	TS mice fed 1 6 % l-Arg for 3 months (TS1.6) had the highest weight gain, BMD, BMC and lean body mass compared with other groups.	Arginine	18-23	Trichinella spiralis resistance 1	Mus musculus	38-41
26090102-13	2015	Outcomes observed with TS1.6 and TS3.2 mice, respectively, confirm the hypothesis and reveal l-Arg as part of the mechanism.	Arginine	93-98	Trichinella spiralis resistance 1	Mus musculus	23-26
25538240-4	2015	Our results showed that two specific arginine residues, Arg-141 and Arg-120, are important for the activity of hMPG as the germ line variants R120C and R141Q had reduced enzymatic activity in vitro as well as in mammalian cells.	Arginine	37-45	N-methylpurine DNA glycosylase	Homo sapiens	111-115
25538240-4	2015	Our results showed that two specific arginine residues, Arg-141 and Arg-120, are important for the activity of hMPG as the germ line variants R120C and R141Q had reduced enzymatic activity in vitro as well as in mammalian cells.	Arginine	56-59	N-methylpurine DNA glycosylase	Homo sapiens	111-115
25538240-4	2015	Our results showed that two specific arginine residues, Arg-141 and Arg-120, are important for the activity of hMPG as the germ line variants R120C and R141Q had reduced enzymatic activity in vitro as well as in mammalian cells.	Arginine	68-71	N-methylpurine DNA glycosylase	Homo sapiens	111-115
25564099-2	2015	The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells.	Arginine	102-105	cathepsin B	Homo sapiens	169-180
25252293-3	2015	Particularly, the relation between 2827 A&gt;G polymorphism of the SIRT1 positioned on exon 2, leading to conversion of histidine to arginine, and the formation of CVD is not known yet.	Arginine	133-141	sirtuin 1	Homo sapiens	67-72
25460044-9	2015	Two arginines located in positions +4 and +8 of Ser552 are essential for the interaction with the PH domain, as well as for the inhibition of membrane recruitment of unphosphorylated Gab1.	Arginine	4-13	GRB2 associated binding protein 1	Homo sapiens	183-187
11832492-6	2002	The reaction products from the digestion of HGF/NK1 by fXa were separated under reducing conditions, and the cleavage site, as determined by N-terminal sequencing, was located C-terminal to arginine 134.	Arginine	190-198	hepatocyte growth factor	Rattus norvegicus	44-47
11815617-9	2002	Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.	Arginine	34-42	serine and arginine rich splicing factor 5	Homo sapiens	68-73
11815617-9	2002	Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.	Arginine	34-42	serine and arginine rich splicing factor 1	Homo sapiens	86-89
25211641-5	2015	Here we report the first Japanese family with PFBC carrying a mutation in PDGFB, which causes the substitution of an arginine with a stop codon at amino acid 149 of the PDGF-B protein (p. Arg149*).	Arginine	117-125	platelet derived growth factor subunit B	Homo sapiens	74-79
11815617-9	2002	Recognition motifs for the serine/arginine-rich (SR) proteins SC35, SRp40, SRp55, and SF2/ASF involved in alternative RNA splicing were predicted in exon 12.	Arginine	34-42	serine and arginine rich splicing factor 1	Homo sapiens	90-93
11997094-6	2002	Citrin, ASS, CPS and Ornt1 showed similar patterns of developmental changes in the liver and small intestine, where they play a role in urea and arginine synthesis.	Arginine	145-153	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
11997094-6	2002	Citrin, ASS, CPS and Ornt1 showed similar patterns of developmental changes in the liver and small intestine, where they play a role in urea and arginine synthesis.	Arginine	145-153	solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15	Mus musculus	21-26
25488663-6	2015	In 50 mm NaCl buffer, atomistic scattering modeling showed that both C3b and C3u adopted a compact structure, similar to the C3b crystal structure in which its TED and macroglobulin 1 (MG1) domains were connected through the Arg(102)-Glu(1032) salt bridge.	Arginine	225-228	complement C3	Homo sapiens	69-72
12139779-2	2002	mediated pathway and L-arginine has been proposed to impair intracellular pH (pH(i)) regulation via vacuolar type H(+)-ATPase in macrophage.	Arginine	21-31	glucose-6-phosphate isomerase	Oryctolagus cuniculus	78-83
25488663-11	2015	Because the Arg(102)-Glu(1032) salt bridge is essential for the C3b-Factor H complex during the regulatory control of C3b, the known clinical associations of the major C3S (Arg(102)) and disease-linked C3F (Gly(102)) allotypes of C3b were experimentally explained for the first time.	Arginine	12-15	complement C3	Homo sapiens	64-67
25488663-11	2015	Because the Arg(102)-Glu(1032) salt bridge is essential for the C3b-Factor H complex during the regulatory control of C3b, the known clinical associations of the major C3S (Arg(102)) and disease-linked C3F (Gly(102)) allotypes of C3b were experimentally explained for the first time.	Arginine	12-15	complement C3	Homo sapiens	118-121
25488663-11	2015	Because the Arg(102)-Glu(1032) salt bridge is essential for the C3b-Factor H complex during the regulatory control of C3b, the known clinical associations of the major C3S (Arg(102)) and disease-linked C3F (Gly(102)) allotypes of C3b were experimentally explained for the first time.	Arginine	12-15	complement C3	Homo sapiens	118-121
25607823-2	2015	RESULTS: The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p&lt;0.001).	Arginine	50-58	serum amyloid A1 cluster	Homo sapiens	22-25
11756446-6	2002	Results revealed that Arg(130) and Arg(134) are critical for the autocatalytic primary processing of the prosegment and for the subsequent efficient exit of SKI-1 from the endoplasmic reticulum.	Arginine	22-25	membrane bound transcription factor peptidase, site 1	Homo sapiens	157-162
11756446-6	2002	Results revealed that Arg(130) and Arg(134) are critical for the autocatalytic primary processing of the prosegment and for the subsequent efficient exit of SKI-1 from the endoplasmic reticulum.	Arginine	35-38	membrane bound transcription factor peptidase, site 1	Homo sapiens	157-162
25203060-4	2015	We show that p300/CBP associated factor (PCAF)/GCN5 activity depends on the presence of a distal arginine residue of its histone H3 substrate.	Arginine	97-105	lysine acetyltransferase 2A	Homo sapiens	47-51
12051975-3	2002	We have tentatively chosen seven transmembrane helices, TM1, TM2, TM4, TM8, TM10, TM12 and TM13 to form a conical channel using the well-established Glu 681 of TM8 and candidates Lys 826 and Arg 730 of TM12-13 and TM10, respectively, to form the inverting basket.	Arginine	191-194	tetraspanin 16	Homo sapiens	71-74
12051975-3	2002	We have tentatively chosen seven transmembrane helices, TM1, TM2, TM4, TM8, TM10, TM12 and TM13 to form a conical channel using the well-established Glu 681 of TM8 and candidates Lys 826 and Arg 730 of TM12-13 and TM10, respectively, to form the inverting basket.	Arginine	191-194	tetraspanin 16	Homo sapiens	160-163
25480565-2	2015	Although Bw4 residues Ile(80) and Arg(83) directly interact with KIR3DL1*001, their precise role in determining KIR3DL1-HLA-Bw4 specificity remains unclear.	Arginine	34-37	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	65-72
11777907-2	2002	The interaction of beta(2)-adaptin with beta-arrestin involves critical arginine residues in the C-terminal domain of beta-arrestin and plays an important role in initiating clathrin-mediated endocytosis of the beta(2)-adrenergic receptor (beta(2)AR) (Laporte, S. A., Oakley, R. H., Holt, J.	Arginine	72-80	adaptor related protein complex 2 subunit beta 1	Homo sapiens	19-34
25480565-8	2015	Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding.	Arginine	81-84	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	114-121
11777907-2	2002	The interaction of beta(2)-adaptin with beta-arrestin involves critical arginine residues in the C-terminal domain of beta-arrestin and plays an important role in initiating clathrin-mediated endocytosis of the beta(2)-adrenergic receptor (beta(2)AR) (Laporte, S. A., Oakley, R. H., Holt, J.	Arginine	72-80	adrenoceptor beta 2	Homo sapiens	211-238
11777907-2	2002	The interaction of beta(2)-adaptin with beta-arrestin involves critical arginine residues in the C-terminal domain of beta-arrestin and plays an important role in initiating clathrin-mediated endocytosis of the beta(2)-adrenergic receptor (beta(2)AR) (Laporte, S. A., Oakley, R. H., Holt, J.	Arginine	72-80	adrenoceptor beta 2	Homo sapiens	240-249
25480565-8	2015	Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu(76)-Arg(83) interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the alpha1 helix that is less permissive for KIR3DL1 binding.	Arginine	81-84	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	220-227
25567906-1	2015	Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.	Arginine	49-57	solute carrier family 38 member 9	Homo sapiens	33-40
25567906-5	2015	SLC38A9 transports arginine with a high Michaelis constant, and loss of SLC38A9 represses mTORC1 activation by amino acids, particularly arginine.	Arginine	19-27	solute carrier family 38 member 9	Homo sapiens	0-7
25567906-5	2015	SLC38A9 transports arginine with a high Michaelis constant, and loss of SLC38A9 represses mTORC1 activation by amino acids, particularly arginine.	Arginine	137-145	solute carrier family 38 member 9	Homo sapiens	72-79
25567906-7	2015	Thus, SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.	Arginine	95-103	solute carrier family 38 member 9	Homo sapiens	6-13
11854619-8	2002	In an in vitro study, MnSOD mRNA expression peaked at 2 hours after the addition of arginine to culture medium, whereas apoptosis was increased at 24 hours.	Arginine	84-92	superoxide dismutase 2	Rattus norvegicus	22-27
25362567-0	2015	Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of beta-actin arginylation.	Arginine	0-8	POTE ankyrin domain family member F	Homo sapiens	123-133
12074715-5	2002	The HLA Cw*0105 differs from Cw*0102 at positions 361 and 368 in exon 3 leading to a Trp to Arg and Cys to Ser substitution, respectively.	Arginine	92-95	major histocompatibility complex, class I, C	Homo sapiens	4-10
25362567-6	2015	Also, arginine deprivation in glioblastoma evoked specific changes in actin assembly, decreased beta-actin filament content, and affected its N-terminal arginylation.	Arginine	6-14	POTE ankyrin domain family member F	Homo sapiens	96-106
11751879-0	2002	Xaa-Arg-Gly triplets in the collagen triple helix are dominant binding sites for the molecular chaperone HSP47.	Arginine	4-7	serpin family H member 1	Homo sapiens	105-110
25362567-7	2015	We suggest that alterations in organization of beta-actin resulted from a decrease of its arginylation could be responsible for the observed effects of arginine deprivation on cell invasiveness and migration.	Arginine	152-160	POTE ankyrin domain family member F	Homo sapiens	47-57
11751879-5	2002	The HSP47 binding was observed only when Arg residues were incorporated in the Yaa positions of the Xaa-Yaa-Gly triplets.	Arginine	41-44	serpin family H member 1	Homo sapiens	4-9
26320504-12	2015	The XRCC1 Gln339Arg, Arg/Arg homozygote was also associated with increased risk but statistically this was non-significant.	Arginine	16-19	X-ray repair cross complementing 1	Homo sapiens	4-9
11751879-7	2002	The recognition of the Arg residue by HSP47 was specific to its side-chain structure because replacement of the Arg residue by other basic amino acids decreased the affinity to HSP47.	Arginine	23-26	serpin family H member 1	Homo sapiens	38-43
26320504-12	2015	The XRCC1 Gln339Arg, Arg/Arg homozygote was also associated with increased risk but statistically this was non-significant.	Arginine	21-24	X-ray repair cross complementing 1	Homo sapiens	4-9
11698398-2	2002	ASL is part of the urea and arginine-citrulline cycles and catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate.	Arginine	118-126	argininosuccinate lyase	Homo sapiens	0-3
26434847-6	2015	The overall association between the XRCC1 polymorphism and the CRC cases was found to be significant (p&lt;0.05) with both the heterozygous genotype (Arg/Trp) as well as homozygous variant genotype (Trp/Trp) being moderately associated with the elevated risk for CRC [OR=2.01 (95% CI=1.03-3.94) and OR=5.2(95% CI=1.42-19.5)] respectively.	Arginine	150-153	X-ray repair cross complementing 1	Homo sapiens	36-41
11814357-9	2002	Moreover, they emphasize the importance of the S-28(1-12) segment joining Arg(-15) and Arg(-2)Lys(-1) cleavage sites whose conformational organization is essential for controlling their accessibility to the appropriate processing proteases.	Arginine	74-77	somatostatin	Homo sapiens	47-51
25684477-9	2015	When stratified by source of control, we observed an increased lung cancer risk among subjects carrying XRCC1 codon 399 Arg/Gln+Gln/Gln genotype on the basis of hospitalized patient-based controls (OR=1.21, 95%CI: 1.04-1.42) and among subjects carrying XRCC1 codon 399 Gln/Gln genotype on the basis of healthy subject-based controls (OR=1.22, 95%CI: 1.04-1.43).	Arginine	120-123	X-ray repair cross complementing 1	Homo sapiens	104-109
11814357-9	2002	Moreover, they emphasize the importance of the S-28(1-12) segment joining Arg(-15) and Arg(-2)Lys(-1) cleavage sites whose conformational organization is essential for controlling their accessibility to the appropriate processing proteases.	Arginine	87-90	somatostatin	Homo sapiens	47-51
11843119-5	2002	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the conversion of radiolabeled arginine to radiolabeled citrulline.	Arginine	107-115	nitric oxide synthase 2	Equus caballus	0-31
11843119-5	2002	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the conversion of radiolabeled arginine to radiolabeled citrulline.	Arginine	107-115	nitric oxide synthase 2	Equus caballus	33-37
25205713-9	2015	Arg and Lys residues located within the 40 residue spanning connecting peptide of fetuin-A were identified as cleavage sites for matriptase-2.	Arginine	0-3	alpha-2-HS-glycoprotein	Mus musculus	82-90
11773414-9	2002	The domain of G4 required for binding to FPPS was restricted to an amphipathic alpha-helix rich in arginine residues.	Arginine	99-107	farnesyl diphosphate synthase	Homo sapiens	41-45
25579789-3	2015	To identify the amino acid residues of ABCA1 involved in substrate recognition and transport, we applied arginine scan mutagenesis to residues L821-E843 of human ABCA1 and predicted the environment to which each residue is exposed.	Arginine	105-113	ATP binding cassette subfamily A member 1	Homo sapiens	39-44
11850543-5	2002	All MRT samples had missense mutations in the human KRT 8 gene, i.e., Arg89 --&gt; Cys (5/7); Arg --&gt; Cys251 (3/7); Glu267 --&gt; Lys (6/7); Ser290 --&gt; Ile, Met; (7/7) and Arg301 --&gt; His(4/7), none of which was detected in any control samples.	Arginine	70-73	keratin 8	Homo sapiens	52-57
25579789-3	2015	To identify the amino acid residues of ABCA1 involved in substrate recognition and transport, we applied arginine scan mutagenesis to residues L821-E843 of human ABCA1 and predicted the environment to which each residue is exposed.	Arginine	105-113	ATP binding cassette subfamily A member 1	Homo sapiens	162-167
26662652-9	2015	L-arg supplementation protected against increases in MMP-2 and MMP-9 in Group 3 (A) and 4 (AC).	Arginine	0-5	matrix metallopeptidase 9	Rattus norvegicus	63-68
12141919-0	2002	Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds.	Arginine	93-96	cathepsin E	Homo sapiens	39-50
12141919-0	2002	Distinct cleavage specificity of human cathepsin E at neutral pH with special preference for Arg-Arg bonds.	Arginine	97-100	cathepsin E	Homo sapiens	39-50
25417848-10	2015	This mutation results in a deleterious amino acid substitution (p.Arg448Trp) of a highly conserved arginine residue in the rBAT protein encoded by the SLC3A1 gene.	Arginine	99-107	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	123-127
11867224-5	2002	In addition to the N-terminal part, which is similar to the human protein, AtCBP20 has a long C-terminus rich in arginine, glycine and aspartate residues.	Arginine	113-121	CAP-binding protein 20	Arabidopsis thaliana	75-82
11777982-4	2002	In this study, we demonstrate that stimulation of murine peritoneal macrophages with MSP results in the RON-dependent up-regulation of arginase, an enzyme associated with alternative activation that competes with iNOS for the substrate L-arginine, the products of which are involved in cell proliferation and matrix synthesis.	Arginine	236-246	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	85-88
11742806-9	2002	It is concluded that modulation of endothelial arginine transport by TNF-alpha or lipopolysaccharide occurs exclusively through changes in CAT2B and CAT1 expression and is dissociated from stimulation of nitric oxide production.	Arginine	47-55	solute carrier family 7 member 1	Homo sapiens	149-153
25803482-7	2015	L-arginine attenuated the histopathological score and MPO activity.	Arginine	0-10	myeloperoxidase	Mus musculus	54-57
25286400-0	2015	Expression of bioactive soluble human stem cell factor (SCF) from recombinant Escherichia coli by coproduction of thioredoxin and efficient purification using arginine in affinity chromatography.	Arginine	159-167	KIT ligand	Homo sapiens	38-54
25286400-0	2015	Expression of bioactive soluble human stem cell factor (SCF) from recombinant Escherichia coli by coproduction of thioredoxin and efficient purification using arginine in affinity chromatography.	Arginine	159-167	KIT ligand	Homo sapiens	56-59
11782367-7	2002	Transient expression of dominant-negative p53 ((175)Arg--&gt;His) counteracted the detrimental effects of BPDE on BRCA-1 promoter activity and protein levels.	Arginine	52-55	BRCA1 DNA repair associated	Homo sapiens	114-120
25161153-4	2015	The ligand binding extracellular domain of VEGFR-2 is composed of seven immunoglobulin-like domains highly decorated with N-glycosylation, while its cytoplasmic domain is subject to multiple PTMs including Tyr, Ser/Thr phosphorylation, Arg and Lys methylation, acetylation and ubiquitination.	Arginine	236-239	kinase insert domain receptor	Homo sapiens	43-50
11906459-14	2002	These results suggest that exogenously administered L-arginine exerts a protective effect against stress-induced gastric mucosal lesions in rats at least partly through preservation of gastric mucus synthesis and secretion by NO produced from the administered amino acid via cNOS in gastric mucosal tissue.	Arginine	52-62	nitric oxide synthase 3	Rattus norvegicus	275-279
25339174-5	2014	In the human dopamine transporter (DAT), the corresponding residues are Arg-85 and Asp-476.	Arginine	72-75	solute carrier family 6 member 3	Homo sapiens	13-33
11856309-11	2002	The tripeptide Arg-Gly-Gly corresponded uniquely to the three C-terminal residues of ubiquitin, demonstrating the presence of ubiquitinated histone H1A.	Arginine	15-18	H1.1 linker histone, cluster member	Homo sapiens	140-151
11929627-2	2002	Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene.	Arginine	95-103	leptin	Bos taurus	150-156
25339174-5	2014	In the human dopamine transporter (DAT), the corresponding residues are Arg-85 and Asp-476.	Arginine	72-75	solute carrier family 6 member 3	Homo sapiens	35-38
25339174-7	2014	The DAT R85D mutant has a complete loss of function, but the additional insertion of an arginine in opposite position (R85D/D476R), causing a charge reversal, results in a rescue of binding sites for the cocaine analogue [(3)H]CFT.	Arginine	88-96	solute carrier family 6 member 3	Homo sapiens	4-7
25301942-5	2014	Mutagenesis of these lysines to arginines completely abolishes the autoacetylation of TIP60.	Arginine	32-41	lysine acetyltransferase 5	Homo sapiens	86-91
11900275-7	2002	RESULTS: A significant enrichment in DQB1 alleles encoding for an amino acid different from Asp in position 57 (NA) and DQA1 alleles encoding for Arg in position 52 was observed in diabetic subjects and first-degree relatives as compared to controls.	Arginine	146-149	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	37-41
11939578-0	2002	Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Pro-carboxypeptidase R (proCPR), also known as thrombin-activatable fibrinolysis inhibitor (TAFI), precursor of carboxypeptidase U and plasma carboxypeptidase B is present in plasma and following activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a.	Arginine	347-355	complement C3	Homo sapiens	16-19
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Arginine	104-112	carboxypeptidase N subunit 1	Homo sapiens	0-18
12008932-1	2002	Carboxypeptidase N (CPN) and carboxypeptidase R (CPR) are present in fresh serum, and cleave C-terminal arginine or lysine residues from bioactive peptides such as anaphylatoxins and kinins resulting in regulation of peptide activity.	Arginine	104-112	carboxypeptidase N subunit 1	Homo sapiens	20-23
24385142-8	2014	The activity of argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL), the two enzymes of Cit-NO cycle catalyzing synthesis of Arg, showed an increase in TAA rats, consistent with increased ASS and ASL protein expression, by ~30 and ~20 %, respectively.	Arginine	140-143	argininosuccinate synthase 1	Rattus norvegicus	16-42
12008933-2	2002	Since removal of the C-terminal arginine abrogates the anaphylatoxin activity of C3a and C5a, CPR and CPN are regarded as anaphylatoxin inactivators.	Arginine	32-40	complement C3	Homo sapiens	81-84
25253689-0	2014	trans-Acting arginine residues in the AAA+ chaperone ClpB allosterically regulate the activity through inter- and intradomain communication.	Arginine	13-21	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	53-57
11747432-1	2001	Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction involved in the biosynthesis of arginine in all species and in the production of urea in ureotelic species.	Arginine	89-97	argininosuccinate lyase	Homo sapiens	25-28
11747433-1	2001	Argininosuccinate lyase (ASL) is a homotetrameric enzyme that catalyzes the reversible cleavage of argininosuccinate to arginine and fumarate.	Arginine	120-128	argininosuccinate lyase	Homo sapiens	0-23
25253689-4	2014	Several AAA+ proteins, including ClpB/Hsp104, possess a pair of such trans-acting arginines in the N-terminal nucleotide binding domain (NBD1), both of which were shown to be crucial for oligomerization and ATPase activity.	Arginine	82-91	caseinolytic mitochondrial matrix peptidase chaperone subunit B	Homo sapiens	33-37
11747433-1	2001	Argininosuccinate lyase (ASL) is a homotetrameric enzyme that catalyzes the reversible cleavage of argininosuccinate to arginine and fumarate.	Arginine	120-128	argininosuccinate lyase	Homo sapiens	25-28
25294873-1	2014	Protein arginine methyltransferase 7 (PRMT7) methylates arginine residues on various protein substrates and is involved in DNA transcription, RNA splicing, DNA repair, cell differentiation, and metastasis.	Arginine	8-16	protein arginine methyltransferase 7	Homo sapiens	38-43
11747826-7	2001	Thus, arginine-specific histone methylation by CARM1 is an important part of the transcriptional activation process.	Arginine	6-14	coactivator associated arginine methyltransferase 1	Homo sapiens	47-52
25402489-5	2014	sEH expression increased at the protein and messenger RNA levels, as well as enzymatic activity in the early phase of cerulein- and arginine-induced AP in mice.	Arginine	132-140	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
12369930-4	2001	The mitochondrial isoform of dUTPase (DUT-M) begins as a 31 kilodalton precursor protein containing an arginine-rich, amino-terminal presequence required for targeting to the mitochondria.	Arginine	103-111	Deoxyuridine triphosphatase	Drosophila melanogaster	29-36
12369930-4	2001	The mitochondrial isoform of dUTPase (DUT-M) begins as a 31 kilodalton precursor protein containing an arginine-rich, amino-terminal presequence required for targeting to the mitochondria.	Arginine	103-111	deoxyuridine triphosphatase	Homo sapiens	38-41
25402489-8	2014	Further, Ephx2 KO mice exhibited decreased cerulein- and arginine-induced NF-kappaB inflammatory response, MAPKs activation and decreased cell death.	Arginine	57-65	epoxide hydrolase 2, cytoplasmic	Mus musculus	9-14
25402489-9	2014	Conclusions -These findings demonstrate a novel role for sEH in the progression of cerulein- and arginine-induced AP.	Arginine	97-105	epoxide hydrolase 2, cytoplasmic	Mus musculus	57-60
25584213-14	2014	RESULTS: XRCC1 gene polymorphism is associated with increased risk of lung cancer when the Arg/Arg genotype was used as the reference group.	Arginine	91-94	X-ray repair cross complementing 1	Homo sapiens	9-14
25234929-3	2014	Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of KSHV K8beta RNA.	Arginine	27-35	serine and arginine rich splicing factor 3	Homo sapiens	60-65
11792805-4	2001	Single or double mutations of glutamine to glutamate or to arginine in the central zero layer residues of SNAP-25 did not impair the extent, time course or Ca2+-dependency of exocytosis in PC12 cells.	Arginine	59-67	synaptosome associated protein 25	Rattus norvegicus	106-113
11811387-8	2001	Beta2-adrenoceptor stimulation increases forearm blood flow (FBF) by activating the L-arginine/NO pathway but nebivolol lacks direct beta2-adrenoceptor agonist activity.	Arginine	84-94	adrenoceptor beta 2	Homo sapiens	0-18
25234929-3	2014	Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of KSHV K8beta RNA.	Arginine	27-35	ORF57	Human gammaherpesvirus 8	127-132
25386179-5	2014	There is also a type-II arginase (Arg-II), which is expressed in macrophages and prevalently viewed as having the same function as Arg-I in the cells.	Arginine	34-37	arginase 2	Homo sapiens	16-32
11738098-7	2001	RESULTS: Pretreatment of rats with the mixture of CG plus Arg could significantly lower the blood ammonia level (P&lt;0.05), increase the activity of CPS I (P&lt;0.05), improve abnormal behavior associated with ammonia intoxication (P&lt;0.05), and increase BUN (P&lt;0.05), as compared with the PBS-injected control group.	Arginine	58-61	carbamoyl-phosphate synthase 1	Rattus norvegicus	150-155
25072916-0	2014	High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy.	Arginine	114-122	coactivator associated arginine methyltransferase 1	Homo sapiens	21-26
11730364-4	2001	N-monomethyl-l-arginine (L-NMMA), a specific inhibitor of the l-arginine pathway, inhibited the MCP-1-induced NO secretion and generation of macrophage-mediated tumoricidal activity against P815 (NO-sensitive, TNF-resistant) cells but not the L929 (TNF-sensitive, NO-resistant) cells.	Arginine	13-23	chemokine (C-C motif) ligand 2	Mus musculus	96-101
11730364-5	2001	These results indicated l-arginine-dependent production of NO to be one of the effector mechanisms contributing to the tumoricidal activity of MCP-1-treated macrophages.	Arginine	24-34	chemokine (C-C motif) ligand 2	Mus musculus	143-148
25072916-9	2014	Furthermore, we found that inhibition of histone 3 arginine 17 (H3R17) asymmetric dimethylation attenuates both CARM1- and high-glucose-induced apoptosis in RPE cells.	Arginine	51-59	coactivator associated arginine methyltransferase 1	Homo sapiens	112-117
25333616-5	2014	We found that leucine, tyrosine, arginine, homoarginine or glucose treatment of the GA1 model cells reduced the gene expression of caspase-3, caspase-8, caspase-9, bax, fos, and jun and restored the intracellular NADH and ATP levels.	Arginine	33-41	caspase 3	Mus musculus	131-140
25333616-5	2014	We found that leucine, tyrosine, arginine, homoarginine or glucose treatment of the GA1 model cells reduced the gene expression of caspase-3, caspase-8, caspase-9, bax, fos, and jun and restored the intracellular NADH and ATP levels.	Arginine	33-41	BCL2-associated X protein	Mus musculus	164-167
11729158-5	2001	The strong dominant trithorax-like phenotypes elicited by this E(z) allele suggest that the mutated arginine-741 plays a critical role in distinguishing between active and inactive chromatin domains of the homeotic gene complexes.	Arginine	100-108	trithorax	Drosophila melanogaster	20-29
25313689-5	2014	Specifically, positively charged Lys/Arg at position 322 and negatively charged Asp/Glu at position 440 occurred more frequently in CXCR4-using viruses, whereas negatively charged Asp/Glu at position 322 and positively charged Arg at position 440 occurred more frequently in R5 strains.	Arginine	37-40	C-X-C motif chemokine receptor 4	Homo sapiens	132-137
24166499-6	2014	Mutation of K76 into arginine (R) abolishes its sumoylation, disrupts merlin cortical cytoskeleton residency and attenuates its stability.	Arginine	21-29	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	70-76
25207865-2	2014	Herein, we report the construction of arginine-glycine-aspartic acid-cysteine (RGDC) tetrapeptide functionalized and 10-hydroxycamptothecin (HCPT)-encapsulated magnetic nanohybrids (RFHEMNs) for integrin alphaVbeta3-targeted drug delivery.	Arginine	38-46	integrin subunit alpha V	Homo sapiens	195-215
25350748-9	2014	This protocol can be employed not only for establishing the methylation status of novel physiological PRMT1 substrates, but also for understanding the basic mechanism of protein arginine methylation.	Arginine	178-186	protein arginine methyltransferase 1	Homo sapiens	102-107
26461340-5	2014	sEH expression increased at the protein and messenger RNA levels, as well as sEH activity in the early phase of cerulein- and arginine-induced AP in mice.	Arginine	126-134	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
26461340-5	2014	sEH expression increased at the protein and messenger RNA levels, as well as sEH activity in the early phase of cerulein- and arginine-induced AP in mice.	Arginine	126-134	epoxide hydrolase 2, cytoplasmic	Mus musculus	77-80
26461340-8	2014	Further, sEH KO mice exhibited decreased cerulein- and arginine-induced NF-?B inflammatory response, MAPKs activation and decreased cell death.	Arginine	55-63	epoxide hydrolase 2, cytoplasmic	Mus musculus	9-12
26461340-9	2014	These findings demonstrate a novel role for sEH in the progression of cerulein- and arginine-induced AP.	Arginine	84-92	epoxide hydrolase 2, cytoplasmic	Mus musculus	44-47
25082513-1	2014	Structure-activity relationship studies of the cyclopentapeptide CXCR4 antagonists (cyclo(-l-/d-Arg(1)-Arg(2)-2-Nal(3)-Gly(4)-d-Tyr(5)-)) suggest that the l-/d-Arg(1)-Arg(2)-2-Nal(3) tripeptide sequence contained within these cyclopentapeptides serves as a recognition motif for peptidic CXCR4 antagonists.	Arginine	95-99	C-X-C motif chemokine receptor 4	Homo sapiens	65-70
25012667-4	2014	Importantly, this interaction leads to the arginine methylation of GATA4 at positions of 229, 265, and 317, which leads to an inhibition of the GATA4 transcriptional activity, predominantly through blocking the p300-mediated acetylation of GATA4 in cardiomyocytes.	Arginine	43-51	GATA binding protein 4	Homo sapiens	67-72
25012667-4	2014	Importantly, this interaction leads to the arginine methylation of GATA4 at positions of 229, 265, and 317, which leads to an inhibition of the GATA4 transcriptional activity, predominantly through blocking the p300-mediated acetylation of GATA4 in cardiomyocytes.	Arginine	43-51	GATA binding protein 4	Homo sapiens	144-149
25012667-4	2014	Importantly, this interaction leads to the arginine methylation of GATA4 at positions of 229, 265, and 317, which leads to an inhibition of the GATA4 transcriptional activity, predominantly through blocking the p300-mediated acetylation of GATA4 in cardiomyocytes.	Arginine	43-51	GATA binding protein 4	Homo sapiens	144-149
25171888-3	2014	We have characterized the molecular basis for the neural tube defects caused by an ENU-induced mutation that results in an arginine-to-cysteine amino acid substitution at position 1838 of mouse Shroom3.	Arginine	123-131	shroom family member 3	Mus musculus	194-201
25068569-5	2014	Of interest are two arginine residues, R181 and R274, that are highly conserved in Vangl protein homologues and found to be independently mutated in VANGL1 (R181Q and R274Q) and VANGL2 (R177H and R270H) in human cases of NTDs.	Arginine	20-28	VANGL planar cell polarity protein 1	Homo sapiens	149-155
25009204-1	2014	Arginine, a semiessential amino acid implicated in diverse cellular processes, is a substrate for two arginases-Arg1 and Arg2-having different expression patterns and functions.	Arginine	0-8	arginase type II	Mus musculus	121-125
25009204-9	2014	Finally, in vitro and in vivo functional assays using DCs exhibiting deregulated Arg2 expression indicated that Arg2-mediated arginine depletion in the extracellular milieu impairs T cell proliferation.	Arginine	126-134	arginase type II	Mus musculus	81-85
25009204-9	2014	Finally, in vitro and in vivo functional assays using DCs exhibiting deregulated Arg2 expression indicated that Arg2-mediated arginine depletion in the extracellular milieu impairs T cell proliferation.	Arginine	126-134	arginase type II	Mus musculus	112-116
25009204-10	2014	These results indicate that miR155-induced repression of Arg2 expression is critical for the ability of DCs to drive T cell activation by controlling arginine availability in the extracellular environment.	Arginine	150-158	arginase type II	Mus musculus	57-61
25111602-5	2014	METHODS AND RESULTS: In mitochondria isolated from failing hearts (sheep rapid pacing model and mouse Mst1 transgenic model) we demonstrated a marked reduction in L-arginine uptake (p&lt;0.05 and p&lt;0.01 respectively) and expression of the principal L-arginine transporter, CAT-1 (p&lt;0.001, p&lt;0.01) compared to controls.	Arginine	163-173	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	102-106
24904080-2	2014	Argininosuccinate lyase (ASL) is the only enzyme in mammals that is capable of synthesizing arginine.	Arginine	92-100	argininosuccinate lyase	Mus musculus	25-28
24997121-6	2014	Arginine-18 (R18) in H1, and R132 and R143 in H7 were found to be the key players of the Ank(GAG)1D4-NTD(CA) interaction.	Arginine	0-8	ankyrin 1	Homo sapiens	89-92
24449198-3	2014	The 1.62 A crystal structure of the A52 Fab fragment reveals an H3 complementarity determining region with four closely spaced arginine residues, creating a positively charged surface to accommodate bound DNA.	Arginine	127-135	ribosomal protein L13	Mus musculus	36-39
24918545-2	2014	N-terminally truncated nonapeptide 4 ([D-Tyr46,D-Pya(4)47,azaGly51,Arg(Me)53]metastin(46-54)) is a representative compound with both potent agonistic activity and metabolic stability.	Arginine	67-70	KiSS-1 metastasis-suppressor	Rattus norvegicus	77-85
24918545-5	2014	Furthermore, [D-Tyr46,D-Trp47,Thr49,azaGly51,Arg(Me)53,Trp54]metastin(46-54) (14) showed 2-fold greater [Ca2+]i-mobilizing activity than metastin(45-54) and an apparent increase in physicochemical stability.	Arginine	45-48	KiSS-1 metastasis-suppressor	Rattus norvegicus	61-69
24918545-5	2014	Furthermore, [D-Tyr46,D-Trp47,Thr49,azaGly51,Arg(Me)53,Trp54]metastin(46-54) (14) showed 2-fold greater [Ca2+]i-mobilizing activity than metastin(45-54) and an apparent increase in physicochemical stability.	Arginine	45-48	KiSS-1 metastasis-suppressor	Rattus norvegicus	137-145
24918545-6	2014	N-terminal acetylation of 14 resulted in the most potent analogue, 22 (Ac-[D-Tyr46,D-Trp47,Thr49,azaGly51,Arg(Me)53,Trp54]metastin(46-54)).	Arginine	106-109	KiSS-1 metastasis-suppressor	Rattus norvegicus	122-130
24852075-11	2014	In contrast, Arg1 expression in the lungs could facilitate the infection through competing with iNOs for l-arginine, preventing generation of nitric oxide for clearance of M. bovis infection.	Arginine	105-115	arginase 1	Bos taurus	13-17
24852075-11	2014	In contrast, Arg1 expression in the lungs could facilitate the infection through competing with iNOs for l-arginine, preventing generation of nitric oxide for clearance of M. bovis infection.	Arginine	105-115	nitric oxide synthase 2	Bos taurus	96-100
25010489-5	2014	BPTI variants carrying Arg, Lys, Ile, Leu or Ala at the P2" position of the binding loop were purified and equilibrium dissociation constants were determined against non-sulfated and sulfated cationic and anionic human trypsins.	Arginine	23-26	spleen trypsin inhibitor I	Bos taurus	0-4
24802387-5	2014	Mutagenesis of the conserved positively charged Arg residues of relaxin-3 demonstrated that B12Arg, B16Arg and B26Arg were all involved in the binding and activation of RXFP4, especially B26Arg.	Arginine	48-51	relaxin family peptide/INSL5 receptor 4	Homo sapiens	169-174
11876023-10	2001	We found that L-arginine inhibited amphetamine-induced stereotypy and haloperidol-induced catalepsy, but intensified CAR.	Arginine	14-24	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	117-120
24732914-7	2014	The structure revealed a unique bent substrate binding mode positioning the histone H3 residues Arg(2) and Lys(4) adjacent to the Haspin phosphorylated threonine into acidic binding pockets.	Arginine	96-99	histone H3 associated protein kinase	Homo sapiens	130-136
11481325-5	2001	Cleavage of tropoelastin with kallikrein, which cleaves after Arg(515) in the central region of the molecule, disrupted the interaction, suggesting that the separated N- and C-terminal fragments were insufficient to determine MAGP-1 binding to intact tropoelastin.	Arginine	62-65	elastin	Homo sapiens	12-24
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	18-23	nitric oxide synthase 1	Rattus norvegicus	123-127
11604223-4	2001	Moreover, L-arginine, the physiological substrate of cNOS, significantly reduced the marked enhancing effect of L-NAME on insulin release and to a lesser extent, at low concentrations, that of 10 mM KCl.	Arginine	10-20	nitric oxide synthase 3	Rattus norvegicus	53-57
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	18-23	nitric oxide synthase 1	Rattus norvegicus	228-232
11592980-5	2001	On the basis of previous observations on the F-ATPases, we have investigated the role of two highly conserved arginine residues present in the last two putative transmembrane segments of the yeast V-ATPase a subunit (Vph1p).	Arginine	110-118	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	217-222
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	82-87	nitric oxide synthase 1	Rattus norvegicus	123-127
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	82-87	nitric oxide synthase 1	Rattus norvegicus	228-232
11600717-4	2001	The expression of c-Fos was dependent on a helper plasmid that encodes rare (Arg)tRNAs.	Arginine	77-80	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	82-87	nitric oxide synthase 1	Rattus norvegicus	123-127
24964848-8	2014	administration of L-Arg combined with CC significantly improved the action of the L-Arg or CC on the content of NO and the nNOS or alpha7nAChR expressions in hippocampus along with the learning and memory behavior of rats; when nNOS or alpha7nAChR was interrupted in advance, the effects of L-Arg combined with CC were also suppressed.	Arginine	82-87	nitric oxide synthase 1	Rattus norvegicus	228-232
24914981-4	2014	The function of anaphylatoxins is regulated by circulating carboxypeptidases that remove their C-terminal arginine residue, yielding C3a-desArg and C5a-desArg.	Arginine	106-114	complement C3	Homo sapiens	133-136
24625390-6	2014	In the event of pairwise combinations of the single nucleotide polymorphisms, a risk elevation was shown for MDM2 GG homozygotes/p53 wild-type Arg in hereditary melanoma (P=0.01).	Arginine	143-146	MDM2 proto-oncogene	Homo sapiens	109-113
11564726-7	2001	Fetal plasma insulin area under the curve (AUC) was larger in UN than in N fetuses during glucose challenge (4.5 +/- 0.6 vs. 2.9 +/- 0.5 nM, p &lt; 0.05) but was not different during arginine challenge.	Arginine	183-191	LOC105613195	Ovis aries	13-20
11574069-4	2001	Replacement of Ala position -2 of pre-P450(SCC) with Arg resulted in an increase in the cleavage rate.	Arginine	53-56	SCC	Bos taurus	43-46
24837102-5	2014	This amplification required arginine residues in the ICOSL cytoplasmic tail that recruited the adaptor protein RACK1 and the kinases PKC and JNK leading to PKC, MAPK, and NF-kappaB activation.	Arginine	28-36	inducible T cell costimulator ligand	Homo sapiens	53-58
11432854-9	2001	Mutant RFC complexes containing rfc2-K71R or rfc3-K59R, carrying a conservative lysine --&gt; arginine mutation, had much milder clamp loading defects that could be partially (rfc2-K71R) or completely (rfc3-K59R) suppressed at high ATP concentrations.	Arginine	94-102	replication factor C subunit 2	Saccharomyces cerevisiae S288C	32-36
11549622-4	2001	To determine the relative importance of these sites for proper DNA metabolism in the cell, the conserved lysine in the Walker A motif of RFC1, RFC2, RFC3, or RFC4 was mutated to either arginine or glutamic acid.	Arginine	185-193	replication factor C subunit 1	Saccharomyces cerevisiae S288C	137-141
24837102-5	2014	This amplification required arginine residues in the ICOSL cytoplasmic tail that recruited the adaptor protein RACK1 and the kinases PKC and JNK leading to PKC, MAPK, and NF-kappaB activation.	Arginine	28-36	receptor for activated C kinase 1	Homo sapiens	111-116
24556046-10	2014	Interestingly, L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis.	Arginine	15-20	argininosuccinate lyase	Mus musculus	67-70
24556046-10	2014	Interestingly, L-Arg at high concentration down-regulates Ass1 and Asl expression by negative feedback to maintain L-Arg homeostasis.	Arginine	115-120	argininosuccinate lyase	Mus musculus	67-70
11527429-6	2001	S100A4 had a greater affinity for wild-type or mutant arg-175-his p53 than for non-muscle myosin.	Arginine	54-57	S100 calcium binding protein A4	Homo sapiens	0-6
24843801-11	2014	Our finding could have important clinical implications since the subjects with A/A and A/B genotypes of ACP1 carrying Arg/Arg genotype are more susceptible to allergic asthma than Pro/Pro genotype.	Arginine	118-121	acid phosphatase 1	Homo sapiens	104-108
24843801-11	2014	Our finding could have important clinical implications since the subjects with A/A and A/B genotypes of ACP1 carrying Arg/Arg genotype are more susceptible to allergic asthma than Pro/Pro genotype.	Arginine	122-125	acid phosphatase 1	Homo sapiens	104-108
24576804-4	2014	For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells.	Arginine	47-50	matrix metallopeptidase 9	Homo sapiens	55-60
11532866-8	2001	Never-smoking XRCC1-399Gln homozygotes had an average DNA adduct level of 15.60 +/- 5.42 compared with 6.16 +/- 0.97 in Gln/Arg heterozygotes and 6.78 +/- 1.10 in Arg/Arg homozygotes (F = 5.237, P = 0.007).	Arginine	124-127	X-ray repair cross complementing 1	Homo sapiens	14-19
11532866-8	2001	Never-smoking XRCC1-399Gln homozygotes had an average DNA adduct level of 15.60 +/- 5.42 compared with 6.16 +/- 0.97 in Gln/Arg heterozygotes and 6.78 +/- 1.10 in Arg/Arg homozygotes (F = 5.237, P = 0.007).	Arginine	163-166	X-ray repair cross complementing 1	Homo sapiens	14-19
11532866-8	2001	Never-smoking XRCC1-399Gln homozygotes had an average DNA adduct level of 15.60 +/- 5.42 compared with 6.16 +/- 0.97 in Gln/Arg heterozygotes and 6.78 +/- 1.10 in Arg/Arg homozygotes (F = 5.237, P = 0.007).	Arginine	163-166	X-ray repair cross complementing 1	Homo sapiens	14-19
11387442-8	2001	Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation.	Arginine	20-23	protein arginine methyltransferase 1	Homo sapiens	63-68
11387442-8	2001	Our finding reveals Arg 3 of H4 as a novel methylation site by PRMT1 and indicates that Arg 3 methylation plays an important role in transcriptional regulation.	Arginine	88-91	protein arginine methyltransferase 1	Homo sapiens	63-68
11502828-9	2001	Sequence analysis of the GH receptor gene revealed a heterozygous mutation resulting in an Arg to Cys change (R161C) in exon 6 in only 1 patient, who had normal GH receptor responsiveness.	Arginine	91-94	growth hormone receptor	Homo sapiens	25-36
11413411-9	2001	A heterozygous single base-pair transition (CTG to CGG, leucine to arginin) was detected in codon 527 of the TGFBI gene in both patients.	Arginine	67-74	transforming growth factor beta induced	Homo sapiens	109-114
11571626-4	2001	A polymorphic change (Arg to Gly) at DCC codon 201 is related to advanced colorectal carcinoma and increases in the tumors with absent DCC protein expression.	Arginine	22-25	DCC netrin 1 receptor	Homo sapiens	37-40
11571626-4	2001	A polymorphic change (Arg to Gly) at DCC codon 201 is related to advanced colorectal carcinoma and increases in the tumors with absent DCC protein expression.	Arginine	22-25	DCC netrin 1 receptor	Homo sapiens	135-138
11279151-8	2001	This study shows that MMP-9 has a unique preference for Arg at both P(2) and P(1), and a preference for Ser/Thr at P(2").	Arginine	56-59	matrix metallopeptidase 9	Homo sapiens	22-27
11410740-6	2001	RESULTS: The L-arginine transport system functioning in the hepatic stellate cells was system y+, possibly mediated by CAT-1 and CAT-2B (Km approximately 50 microM).	Arginine	13-23	solute carrier family 7 member 2	Rattus norvegicus	129-135
11375331-6	2001	Our data show that miconazole, an inhibitor of nNOS cytochrome c reductase activity, either alone for the experiments with arginine or combined with sodium nitroprusside for glucose, is able to restore normal secretory patterns in response to the two secretagogues.	Arginine	123-131	nitric oxide synthase 1	Rattus norvegicus	47-51
11278612-11	2001	In terms of specific PKC isoforms, our results suggest that the presence of Arg-20 in PKC-zeta may contribute to its lack of phorbol ester binding activity.	Arginine	76-79	protein kinase C zeta	Homo sapiens	86-94
11278602-3	2001	Three closely related cationic amino acid transporter genes (Cat1-3) encode the transporters that mediate most arginine uptake in mammalian cells.	Arginine	111-119	solute carrier family 7 member 1	Homo sapiens	61-67
11278602-4	2001	Because CAT2 is induced coordinately with NOS2 in numerous cell types, we investigated a possible role for CAT2-mediated arginine transport in regulating NO production.	Arginine	121-129	dominant cataract 2	Mus musculus	107-111
11278602-5	2001	The complexity of arginine transport systems and their biochemically similar transport properties called for a genetic approach to determine the role of CAT2.	Arginine	18-26	dominant cataract 2	Mus musculus	153-157
11278602-7	2001	Analysis of cytokine-activated macrophages from Cat2(-/-) mice revealed a 92% reduction in NO production and a 95% reduction in l-Arg uptake.	Arginine	128-133	dominant cataract 2	Mus musculus	48-52
11278602-9	2001	In conclusion, our results show that sustained abundant NO synthesis by macrophages requires arginine transport via the CAT2 transporter.	Arginine	93-101	dominant cataract 2	Mus musculus	120-124
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	85-88	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	90-93
11279004-4	2001	Moreover, embryonic fibroblast cells isolated from mice devoid of endogenous Abl and Arg (abl-/- arg-/-) demonstrate increased Crk-CAS coupling and motility.	Arginine	97-100	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	90-93
11279004-5	2001	Conversely, expression of a kinase-active form of Abl or reconstitution of abl-/- arg-/- cells with wild-type Abl prevents Crk-CAS coupling and inhibits cell migration.	Arginine	82-85	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	75-78
11279004-5	2001	Conversely, expression of a kinase-active form of Abl or reconstitution of abl-/- arg-/- cells with wild-type Abl prevents Crk-CAS coupling and inhibits cell migration.	Arginine	82-85	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	110-113
11287558-6	2001	In two study subjects, arginine substitutions at position 306, associated with use of the chemokine coreceptor CXCR4, were preferentially found in CD4 lymphocytes.	Arginine	23-31	C-X-C motif chemokine receptor 4	Homo sapiens	111-116
11275480-1	2001	Nitric oxide synthases (NOS) convert L-arginine and N(omega)-hydroxy-L-arginine to nitric oxide (*NO) and/or nitroxyl (NO(-)) in a NADPH-dependent fashion.	Arginine	37-47	2,4-dienoyl-CoA reductase 1	Homo sapiens	131-136
11261568-12	2001	These results indicate that kidney arginase was readily activated by Arg provided in the water, resulting in an immediate increase in plasma urea and ornithine.	Arginine	69-72	arginase 2	Homo sapiens	28-43
11222476-3	2001	METHODS AND RESULTS: TGF-beta(1) increased L-arginine uptake, and this was associated with a selective increase in cationic amino acid transporter-1 (CAT-1) mRNA.	Arginine	43-53	solute carrier family 7 member 1	Homo sapiens	150-155
11327829-13	2001	The implications of the determined consensus substrate sequence (Arg/Lys)/(Arg/Lys)-Ala for the proposed biological function of OmpT in defense against antimicrobial peptides are discussed.	Arginine	65-68	outer membrane protease	Escherichia coli	128-132
11327829-13	2001	The implications of the determined consensus substrate sequence (Arg/Lys)/(Arg/Lys)-Ala for the proposed biological function of OmpT in defense against antimicrobial peptides are discussed.	Arginine	75-78	outer membrane protease	Escherichia coli	128-132
11180458-7	2001	The activities of arginine (Can1p), proline (Put4p) and general amino acid permease (Gap1p) are decreased more than 20-fold.	Arginine	18-26	arginine permease CAN1	Saccharomyces cerevisiae S288C	28-33
11120661-1	2001	Endothelial cells (EC) metabolize L-arginine mainly by arginase, which exists as two distinct isoforms, arginase I and II.	Arginine	34-44	arginase 1	Bos taurus	104-121
11167791-2	2001	Sequencing of GPIX revealed a homozygous (T-->C) transition at nucleotide 1717 (GenBank/HUMGPIX/M80478), resulting in a Cys(8) (TGT)-->Arg (CGT) replacement in the mature peptide.	Arginine	135-138	UDP glycosyltransferase 8	Homo sapiens	140-143
11434877-5	2001	RESULTS: Twenty-five (12.4%) breast cancer patients and 32 (17.6%) control individuals were found to bear a glutamic acid (Glu) allele for the ADRB2 gene (odds ratio [OR] 0.67, 95% confidence interval [CI] 0.38-1.18), and 60 (30.0%) breast cancer patients and 61 (33.5%) control individuals were found to bear an Arg allele for the ADRB3 gene (OR 0.85, 95% CI 0.55-1.31).	Arginine	313-316	adrenoceptor beta 2	Homo sapiens	143-148
24576804-4	2014	For co-delivery analysis, the obtained PP-PLLD-Arg/DOC/MMP-9 complexes could induce a more significant apoptosis than DOC or MMP-9 used only, and decreased invasive capacity of HNE-1 cells.	Arginine	47-50	matrix metallopeptidase 9	Homo sapiens	125-130
24294904-5	2014	A biochemical study using truncated proteins lacking the defined functional domains of PARP1 showed that the tryptophan-glycine-arginine-rich (WGR) domain of PARP1 was critical for Salidroside binding and subsequent PARP1 activation under oxidative stress.	Arginine	128-136	poly (ADP-ribose) polymerase family, member 1	Mus musculus	87-92
11833938-5	2001	In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors (NOC-18 and spermine-NONOate) or the NOS substrate (L-arginine) stimulate, whereas NOS inhibitors (N(G)-nitro-L-arginine methyl ester and N(G)-monomethyl-L-arginine) reduce the expression and gelatinolytic activity of MMP-2 and MMP-9 in isolated trophoblast cells.	Arginine	191-201	matrix metallopeptidase 9	Homo sapiens	114-119
11007795-2	2000	The amino-terminal region of PRELP differs from that of other leucine-rich repeat proteins in containing a high number of proline and arginine residues.	Arginine	134-142	proline and arginine rich end leucine rich repeat protein	Homo sapiens	29-34
24294904-5	2014	A biochemical study using truncated proteins lacking the defined functional domains of PARP1 showed that the tryptophan-glycine-arginine-rich (WGR) domain of PARP1 was critical for Salidroside binding and subsequent PARP1 activation under oxidative stress.	Arginine	128-136	poly (ADP-ribose) polymerase family, member 1	Mus musculus	158-163
11120830-7	2000	However, changing the Arg at P7 of the DL to a Cys can alter its trafficking and allows for TAP-independent presentation of the Qdm epitope.	Arginine	22-25	nuclear RNA export factor 1	Homo sapiens	92-95
24294904-5	2014	A biochemical study using truncated proteins lacking the defined functional domains of PARP1 showed that the tryptophan-glycine-arginine-rich (WGR) domain of PARP1 was critical for Salidroside binding and subsequent PARP1 activation under oxidative stress.	Arginine	128-136	poly (ADP-ribose) polymerase family, member 1	Mus musculus	158-163
24722645-8	2014	DNA adducts were instead positively associated with occupational cumulative exposure to AAs (p = 0.028), whereas XRCC1 Arg 399 (p&lt;0.006) was related with a decreased adduct levels, but with no impact on BC risk.	Arginine	119-122	X-ray repair cross complementing 1	Homo sapiens	113-118
11106494-1	2000	The rat neuronal nitric oxide synthase (nNOS) catalyzes two monooxygenase reactions successively from L-arginine (L-Arg) to L-citrulline (L-Cit) via N(omega)-hydroxy-L-arginine (OH-Arg) without most of OH-Arg leaving the substrate-binding site.	Arginine	102-112	nitric oxide synthase 1	Rattus norvegicus	8-38
11106494-1	2000	The rat neuronal nitric oxide synthase (nNOS) catalyzes two monooxygenase reactions successively from L-arginine (L-Arg) to L-citrulline (L-Cit) via N(omega)-hydroxy-L-arginine (OH-Arg) without most of OH-Arg leaving the substrate-binding site.	Arginine	102-112	nitric oxide synthase 1	Rattus norvegicus	40-44
11106494-1	2000	The rat neuronal nitric oxide synthase (nNOS) catalyzes two monooxygenase reactions successively from L-arginine (L-Arg) to L-citrulline (L-Cit) via N(omega)-hydroxy-L-arginine (OH-Arg) without most of OH-Arg leaving the substrate-binding site.	Arginine	114-119	nitric oxide synthase 1	Rattus norvegicus	8-38
11106494-1	2000	The rat neuronal nitric oxide synthase (nNOS) catalyzes two monooxygenase reactions successively from L-arginine (L-Arg) to L-citrulline (L-Cit) via N(omega)-hydroxy-L-arginine (OH-Arg) without most of OH-Arg leaving the substrate-binding site.	Arginine	114-119	nitric oxide synthase 1	Rattus norvegicus	40-44
11106494-7	2000	In a single cycle of the nNOS reaction, the rate of monooxygenation was not altered by the CaM concentration but the amount of metabolized L-Arg decreased with the decrease in CaM concentration, showing that the amount of active nNOS was regulated by complex formation between nNOS and CaM.	Arginine	139-144	nitric oxide synthase 1	Rattus norvegicus	25-29
11106494-7	2000	In a single cycle of the nNOS reaction, the rate of monooxygenation was not altered by the CaM concentration but the amount of metabolized L-Arg decreased with the decrease in CaM concentration, showing that the amount of active nNOS was regulated by complex formation between nNOS and CaM.	Arginine	139-144	nitric oxide synthase 1	Rattus norvegicus	229-233
11106494-7	2000	In a single cycle of the nNOS reaction, the rate of monooxygenation was not altered by the CaM concentration but the amount of metabolized L-Arg decreased with the decrease in CaM concentration, showing that the amount of active nNOS was regulated by complex formation between nNOS and CaM.	Arginine	139-144	nitric oxide synthase 1	Rattus norvegicus	229-233
24486546-10	2014	Arginine"s effect on autophagy suppression was not blocked by rapamycin, indicating an mTOR-independent pathway.	Arginine	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	87-91
11211820-0	2000	[In vitro study of C3a des Arg produced by plasma incubation with blood purification materials].	Arginine	27-30	complement C3	Homo sapiens	19-22
11211820-2	2000	The concentration of the activation derivative C3a des Arg was measured by radioimmunoassay (RIA) in human plasma after incubation with these five polymers for 30, 60, 90 and 120 minutes.	Arginine	55-58	complement C3	Homo sapiens	47-50
11211820-3	2000	The experimental results indicated that the presence of polymers caused an increase in C3a des Arg.	Arginine	95-98	complement C3	Homo sapiens	87-90
11211820-6	2000	PES-SO3 activated the least complement C3, and the concentration of C3a des Arg decreased with the increase in sulphonation degree.	Arginine	76-79	complement C3	Homo sapiens	68-71
24497632-5	2014	The presence of lysine in place of arginine in the LLP1 motif resulted in significant impairment of Env expression and consequently virus replication kinetics, Env fusogenicity, and incorporation.	Arginine	35-43	endogenous retrovirus group K member 20	Homo sapiens	100-103
11211820-9	2000	RIA is a reliable and precise quantitative determination of human C3a des Arg and is suitable for testing the activation of complement of various synthetic materials that are utilized or to be utilized in the medical field.	Arginine	74-77	complement C3	Homo sapiens	66-69
24497632-5	2014	The presence of lysine in place of arginine in the LLP1 motif resulted in significant impairment of Env expression and consequently virus replication kinetics, Env fusogenicity, and incorporation.	Arginine	35-43	endogenous retrovirus group K member 20	Homo sapiens	160-163
10948199-1	2000	A human RNase III gene encodes a protein of 160 kDa with multiple domains, a proline-rich, a serine- and arginine-rich, and an RNase III domain.	Arginine	105-113	drosha ribonuclease III	Homo sapiens	8-17
24497632-7	2014	Our findings demonstrate that the conservative lysine substitutions significantly affect Env functional properties indicating a unique functional role for the highly conserved arginines in the LLP motifs.	Arginine	176-185	endogenous retrovirus group K member 20	Homo sapiens	89-92
24497632-9	2014	We propose that these arginines may provide unique functions for Env interaction with viral or cellular cofactors that then influence overall Env functional properties.	Arginine	22-31	endogenous retrovirus group K member 20	Homo sapiens	65-68
10956652-2	2000	Two arginine residues in positions B13 and B17 that project like forefinger and middle finger from the helix provide the electrostatic element opposed by the hydrophobic (thumb) element isoleucine (B20), offset from the arginines by about 40 degrees.	Arginine	4-12	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	43-46
10956652-2	2000	Two arginine residues in positions B13 and B17 that project like forefinger and middle finger from the helix provide the electrostatic element opposed by the hydrophobic (thumb) element isoleucine (B20), offset from the arginines by about 40 degrees.	Arginine	220-229	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	43-46
24497632-9	2014	We propose that these arginines may provide unique functions for Env interaction with viral or cellular cofactors that then influence overall Env functional properties.	Arginine	22-31	endogenous retrovirus group K member 20	Homo sapiens	142-145
24488729-8	2014	Reversible Lys addition with CPB removal should be a generally useful method for making hydrophobic peptides that is applicable to any sequence not ending in Arg or Lys.	Arginine	158-161	carboxypeptidase B1	Homo sapiens	29-32
10952978-4	2000	The role of Arg-47 may be to maximize surface contact between PTP1B and the peptide, which contributes to high affinity binding.	Arginine	12-15	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	62-67
23796630-2	2014	Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-aspartic peptides for integrin alpha(v)beta3 targeting.	Arginine	127-135	integrin subunit alpha V	Homo sapiens	166-188
11262611-1	2000	PURPOSE: To investigate corneal deposits associated with kerato-epithelin (KE) in three corneal dystrophies harboring mutations at Arg-124 in the BIGH3 gene.	Arginine	131-134	transforming growth factor beta induced	Homo sapiens	57-73
11262611-1	2000	PURPOSE: To investigate corneal deposits associated with kerato-epithelin (KE) in three corneal dystrophies harboring mutations at Arg-124 in the BIGH3 gene.	Arginine	131-134	transforming growth factor beta induced	Homo sapiens	146-151
24435975-7	2014	However, in a multivariate analysis adjusted for alcohol consumption, smoking, ethnicity, and number of pregnancies, the interaction between the genotypes TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) showed to be associated to RPL, increasing the risk for this condition (OR = 2.58, 95% CI: 1.31-5.07, p = 0.006).	Arginine	160-163	MDM2 proto-oncogene	Homo sapiens	184-188
11132149-4	2000	The FUT1 polymorphisms result in amino acid substitutions at positions 103 (Ala--&gt;Thr) and 286 (Arg--&gt;Glu).	Arginine	99-102	galactoside alpha-(1,2)-fucosyltransferase 1	Sus scrofa	4-8
24435975-7	2014	However, in a multivariate analysis adjusted for alcohol consumption, smoking, ethnicity, and number of pregnancies, the interaction between the genotypes TP53 Arg/Arg (rs1042522) and MDM2 TT (rs2279744) showed to be associated to RPL, increasing the risk for this condition (OR = 2.58, 95% CI: 1.31-5.07, p = 0.006).	Arginine	164-167	MDM2 proto-oncogene	Homo sapiens	184-188
11027289-3	2000	As a result, we have defined two arginine-rich motifs (ARM1 and ARM2) that mediate the RNA binding activity of SU(S).	Arginine	33-41	Su(S)	Drosophila melanogaster	111-116
24297471-2	2014	Carboxypeptidase-B (CBP-B) was used to selectively remove C-terminal arginine or lysine residues from phosphorylated tryptic/Lys-C peptides prior to their MS/MS analysis by CID with a Paul-type ion trap.	Arginine	69-77	carboxypeptidase B1	Homo sapiens	0-18
11215380-2	2000	TAFI is activated by thrombomodulin (TM)-bound thrombin and specifically removes the C-terminal Lys and Arg by its CPB activity.	Arginine	104-107	carboxypeptidase B1	Homo sapiens	115-118
24297471-2	2014	Carboxypeptidase-B (CBP-B) was used to selectively remove C-terminal arginine or lysine residues from phosphorylated tryptic/Lys-C peptides prior to their MS/MS analysis by CID with a Paul-type ion trap.	Arginine	69-77	carboxypeptidase B1	Homo sapiens	20-25
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	75-78	X-ray repair cross complementing 1	Homo sapiens	69-74
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	69-74
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	69-74
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	69-74
11093077-10	2000	The neurogenic relaxation seems to be mediated exclusively by nitric oxide synthesized from L-arginine in perivascular nerves that activates guanylate cyclase and produces cyclic GMP in smooth muscle.	Arginine	92-102	5'-nucleotidase, cytosolic II	Homo sapiens	179-182
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	69-74
24390232-6	2014	The results of the subgroup analysis by ethnicity indicated that the XRCC1 Arg399Gln polymorphism was associated with increased risk of HCC in Asian populations using the co-dominant model (Arg/Gln vs. Arg/Arg, OR 1.41, 95 % CI 1.06-1.87) and the dominant model (Gln/Gln vs. Arg/Gln + Arg/Arg, OR 1.35, 95 % CI 1.03-1.76).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	69-74
10948200-2	2000	In this study, we randomly mutated two specific residues within the human RXRalpha identity box region previously identified as important determinants in heterodimerization (i.e. Ala(416) and Arg(421)).	Arginine	192-195	retinoid X receptor alpha	Homo sapiens	74-82
24120346-9	2014	The degradomic analysis showed that KLK4-7 expression mostly affected cleavage sites C-terminal to arginine, corresponding to the preference of kallikreins 4, 5 and 6.	Arginine	99-107	kallikrein related peptidase 4	Homo sapiens	36-40
10974409-4	2000	Using a multiplex polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology, allelic variants of the XRCC1 gene at codons 194 (Arg--&gt;Trp) (194Trp) and 399 (Arg--&gt;Gln) (399Gln), were analyzed in DNA from lymphocytes of 48 newly-diagnosed colorectal cancer cases and 48 age- and sex-matched controls.	Arginine	159-162	X-ray repair cross complementing 1	Homo sapiens	133-138
10974409-4	2000	Using a multiplex polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology, allelic variants of the XRCC1 gene at codons 194 (Arg--&gt;Trp) (194Trp) and 399 (Arg--&gt;Gln) (399Gln), were analyzed in DNA from lymphocytes of 48 newly-diagnosed colorectal cancer cases and 48 age- and sex-matched controls.	Arginine	191-194	X-ray repair cross complementing 1	Homo sapiens	133-138
24324264-6	2014	Surprisingly, young Arg-61 mice had more mitotic doublecortin-positive cells in the subgranular zone; mRNA levels of brain-derived neurotrophic factor (BDNF) and TrkB were also higher in 3-month-old Arg-61 hippocampus compared with C57BL/6J mice.	Arginine	20-23	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	162-166
24418547-5	2014	Our results identified the arginine at position 14 of the SIV Vif as a critical residue for virus restriction by rhA3D, rhA3G and rhA3H.	Arginine	27-35	Vif	Human immunodeficiency virus 1	62-65
24761895-8	2014	For the XRCC1 Arg280His polymorphism, the frequency of Arg allele was 90.0% and 89.0% in cases and controls, respectively and for XRCC1 Arg399Gln the frequency of the Arg allele was 72.0% and 72.8% in cases and controls respectively.	Arginine	14-17	X-ray repair cross complementing 1	Homo sapiens	8-13
24761895-8	2014	For the XRCC1 Arg280His polymorphism, the frequency of Arg allele was 90.0% and 89.0% in cases and controls, respectively and for XRCC1 Arg399Gln the frequency of the Arg allele was 72.0% and 72.8% in cases and controls respectively.	Arginine	55-58	X-ray repair cross complementing 1	Homo sapiens	8-13
24727379-7	2014	The structure establishes that the Tat-TAR recognition motif (TRM) in Cyclin T1 interacts with both Tat and AFF4, leading to the exposure of arginine side chains for binding to TAR RNA.	Arginine	141-149	Tat	Human immunodeficiency virus 1	35-38
24404772-2	2014	The DRY motif (Asp, Arg, Tyr) of the intracellular loop 2 (ICL2), which is highly conserved in the GPCRs has been shown to be essential for the stability of folding of CCR5 and the interaction with beta-arrestin.	Arginine	20-23	C-C motif chemokine receptor 5	Homo sapiens	168-172
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	76-84	interferon alpha 14	Homo sapiens	173-184
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	107-110	interferon alpha 14	Homo sapiens	173-184
23962002-6	2014	Further analyses demonstrated that site-specific mutagenesis of the 2 basic arginine residues (amino acids Arg(216) and Arg(217)) in the NS5A is critical for IRF-7-mediated IFN-alpha14 promoter regulation.	Arginine	120-123	interferon alpha 14	Homo sapiens	173-184
23875992-4	2014	Increased l-arginine uptake via hCAT-1 and NO synthesis by eNOS is associated with GDM.	Arginine	10-20	solute carrier family 7 member 1	Homo sapiens	32-38
24206140-2	2013	In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression.	Arginine	46-49	integrin subunit alpha V	Homo sapiens	83-103
24206140-2	2013	In the last decades, a series of radiolabeled Arg-Gly-Asp (RGD) peptides targeting integrin alphavbeta3 has been prepared and optimized for positron emission tomography (PET) and single-photon-emission computed tomography (SPECT) imaging of integrin alphavbeta3 expression.	Arginine	46-49	integrin subunit alpha V	Homo sapiens	241-261
23994446-7	2013	l-Arginine initiated relaxations (EC50, 5.8+-0.7mM; n=9) were inhibited by arginine decarboxylase (ADC) inhibitor, difluoromethylarginine (DFMA) (EC50, 18.3+-1.3mM; n=5) suggesting that arginine-induced vessel relaxation was mediated by agmatine formation.	Arginine	0-10	antizyme inhibitor 2	Rattus norvegicus	75-97
24078636-5	2013	Here, we report that CHERP, containing a Pro-rich region and a phosphorylated Ser/Arg-rich RS-like domain, is a novel Ca(2+)-dependent ALG-2-interactive target in the nucleus.	Arginine	82-85	calcium homeostasis endoplasmic reticulum protein	Homo sapiens	21-26
24078636-5	2013	Here, we report that CHERP, containing a Pro-rich region and a phosphorylated Ser/Arg-rich RS-like domain, is a novel Ca(2+)-dependent ALG-2-interactive target in the nucleus.	Arginine	82-85	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	135-140
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	86-89	coagulation factor X	Homo sapiens	0-9
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	86-89	coagulation factor X	Homo sapiens	11-14
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor X	Homo sapiens	0-9
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor X	Homo sapiens	11-14
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor X	Homo sapiens	0-9
24128092-1	2013	Factor Xa (FXa) proteolytically activates Factor VIII (FVIII) by cleaving P1 residues Arg(372), Arg(740), and Arg(1689).	Arginine	96-99	coagulation factor X	Homo sapiens	11-14
24128092-5	2013	Replacing the Arg(372) flanking sequence with that from the Arg(740) site increased the rate of cleavage at Arg(372), as judged by the ~5-fold increased rate in A1 subunit generation, and reduced the FVIIIa-dependent lag time for in situ FXa generation.	Arginine	14-17	coagulation factor X	Homo sapiens	238-241
24128092-5	2013	Replacing the Arg(372) flanking sequence with that from the Arg(740) site increased the rate of cleavage at Arg(372), as judged by the ~5-fold increased rate in A1 subunit generation, and reduced the FVIIIa-dependent lag time for in situ FXa generation.	Arginine	60-63	coagulation factor X	Homo sapiens	238-241
24128092-5	2013	Replacing the Arg(372) flanking sequence with that from the Arg(740) site increased the rate of cleavage at Arg(372), as judged by the ~5-fold increased rate in A1 subunit generation, and reduced the FVIIIa-dependent lag time for in situ FXa generation.	Arginine	60-63	coagulation factor X	Homo sapiens	238-241
23765399-2	2013	METHODS: Functionalized SWNTs with polymerised polymeric poly(ethylene imine) was linked NGR (Asn-Gly-Arg) tumor-targeting peptide by DSPE-PEG2000-Maleimide via the maleimide group and sulfhydryl group of cysteine, in the end, doxorubicin (DOX) was attached to SWNT-PEI to obtain a SWNT-PEI/DOX/NGR delivery system.	Arginine	102-105	reticulon 4 receptor	Homo sapiens	89-92
23765399-2	2013	METHODS: Functionalized SWNTs with polymerised polymeric poly(ethylene imine) was linked NGR (Asn-Gly-Arg) tumor-targeting peptide by DSPE-PEG2000-Maleimide via the maleimide group and sulfhydryl group of cysteine, in the end, doxorubicin (DOX) was attached to SWNT-PEI to obtain a SWNT-PEI/DOX/NGR delivery system.	Arginine	102-105	reticulon 4 receptor	Homo sapiens	295-298
22793990-1	2013	Arginine modification to citrulline (citrullination) is catalyzed by peptidylarginine deiminases (PADs) and one of the isomers PAD4 is shown to be involved in the gene regulation.	Arginine	0-8	peptidyl arginine deiminase 4	Sus scrofa	127-131
24074032-2	2013	SRPK1 has been shown to phosphorylate the prototype SR protein SRSF1 using a directional mechanism in which 11 serines flanked by arginines are sequentially fed from a docking groove in the large lobe of the kinase domain to the active site.	Arginine	130-139	serine and arginine rich splicing factor 1	Homo sapiens	63-68
24074032-4	2013	To address this, we studied a splice variant of Tra2beta that contains a C-terminal RS domain with short arginine-serine repeats [Tra2beta(DeltaN)].	Arginine	105-113	transformer 2 beta homolog	Homo sapiens	48-56
24074032-8	2013	These large shifts in mechanism are likely to account for the slower net turnover rate of Tra2beta(DeltaN) compared to SRSF1 and may signal fundamental differences in phosphorylation among SR proteins with distinctive arginine-serine profiles.	Arginine	218-226	transformer 2 beta homolog	Homo sapiens	90-98
24048198-9	2013	Furthermore, collectrin directly regulates l-arginine uptake and plasma membrane levels of CAT1 and y(+)LAT1 amino acid transporters in endothelial cells.	Arginine	43-53	collectrin, amino acid transport regulator	Mus musculus	13-23
24048198-10	2013	Treatment with l-arginine modestly lowers blood pressure of collectrin knockout mice.	Arginine	15-25	collectrin, amino acid transport regulator	Mus musculus	60-70
24048198-11	2013	CONCLUSIONS: Collectrin is a consequential link between the transport of l-arginine and endothelial nitric oxide synthase uncoupling in hypertension.	Arginine	73-83	collectrin, amino acid transport regulator	Mus musculus	13-23
23872361-3	2013	In the present study we examined the expression of p62 in the mouse lens and compared its expression in wild-type lenses with that in lenses from knock-in mice with an arginine to glycine mutation in alphaB-crystallin (alphaB-R120G) that is known to cause human hereditary cataract.	Arginine	168-176	nucleoporin 62	Mus musculus	51-54
23928057-6	2013	Both PRMT5 binding and histone H4 arginine 3 methylation (H4R3m2s) are decreased at the GLI1 promoter in MEN1-excised cells.	Arginine	34-42	GLI family zinc finger 1	Homo sapiens	88-92
10924522-5	2000	Reciprocal binding studies revealed that synthetic peptides (encompassing residues Ala(45)-Ser(86)) containing both HK- and thrombin-binding sites, inhibit (125)I-rA1 (Glu(1)-Ser(90)) binding to prothrombin, (125)I-prothrombin binding to FXI, and (125)I-prothrombin fragment 2 (Ser(156)-Arg(271)) binding to FXI.	Arginine	287-290	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	163-166
23842845-3	2013	One of such substitutions, c.2201G&gt;A in STK10 cDNA, replaces an arginine residue to a histidine (R634H) in the encoded protein.	Arginine	67-75	serine/threonine kinase 10	Homo sapiens	43-48
11092456-1	2000	Argininosuccinate lyase (ASL) catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate, a reaction important for the detoxification of ammonia via the urea cycle and for arginine biosynthesis.	Arginine	90-98	argininosuccinate lyase	Homo sapiens	0-23
23733202-2	2013	XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene.	Arginine	35-38	X-ray repair cross complementing 1	Homo sapiens	0-5
10811659-8	2000	These results, along with computer modeling of the CEL protein, indicated that Arg(63) and Arg(423) are not involved directly with monomeric bile salt binding.	Arginine	79-82	carboxyl ester lipase	Rattus norvegicus	51-54
23733202-2	2013	XRCC1 codon 280 polymorphism is an Arg-His change in the XRCC1 gene.	Arginine	35-38	X-ray repair cross complementing 1	Homo sapiens	57-62
10900131-7	2000	SmCL1 exhibited only a low affinity for the cathepsin B diagnostic substrate Z-Arg-Arg-NHMec while SmCL2 failed to cleave this substrate.	Arginine	79-82	cathepsin B	Homo sapiens	44-55
24044607-11	2013	These results provide a framework for studying the importance of the arginine of the D/E/NRY motif in the structure and function of other GPCRs that are involved in cell migration, such as CXCR4 in the mouse, zebrafish, and chicken.	Arginine	69-77	chemokine (C-X-C motif) receptor 4	Mus musculus	189-194
24058583-4	2013	CLIC1 has a single putative transmembrane region that contains only two charged residues: arginine 29 (Arg29) and lysine 37 (Lys37).	Arginine	90-98	chloride intracellular channel 1	Homo sapiens	0-5
10906155-3	2000	Components of the L-arginine metabolic pathway, especially inducible nitric oxide (NO) synthase (iNOS), ornithine aminotransferase (OAT), and ornithine decarboxylase (ODC), have been associated with glomerular scarring.	Arginine	18-28	ornithine decarboxylase, structural 1	Mus musculus	167-170
24016303-6	2013	We have studied if the function of mutant PEX1, PEX6 and PEX12 can be improved by promoting protein folding using the chemical chaperone arginine.	Arginine	137-145	peroxisomal biogenesis factor 6	Homo sapiens	48-52
10903743-1	2000	IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC) belong to the non-glutamate-leucine-arginine motif CXC chemokine family and act solely through the CXCR3 receptor for potent attraction of T lymphocytes.	Arginine	167-175	C-X-C motif chemokine ligand 11	Homo sapiens	80-122
24040099-0	2013	Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue.	Arginine	80-90	transient receptor potential cation channel subfamily V member 6	Homo sapiens	39-44
10935550-2	2000	However, as shown herein, substitution of a highly conserved leucine residue in transmembrane III (TM III) of the hFSHR (Leu 111.18) with arginine causes a 5-fold increase in basal cAMP in transfected cells, consistent with a strong constitutive activation of the hFSHR.	Arginine	138-146	follicle stimulating hormone receptor	Homo sapiens	114-119
10935550-2	2000	However, as shown herein, substitution of a highly conserved leucine residue in transmembrane III (TM III) of the hFSHR (Leu 111.18) with arginine causes a 5-fold increase in basal cAMP in transfected cells, consistent with a strong constitutive activation of the hFSHR.	Arginine	138-146	follicle stimulating hormone receptor	Homo sapiens	264-269
10935550-4	2000	Substitutions of hFSHR(L460) with lysine, alanine, or aspartate show that only arginine causes constitutive activation.	Arginine	79-87	follicle stimulating hormone receptor	Homo sapiens	17-27
10886674-1	2000	Nitric oxide synthase (NOS) requires the substrate L-arginine for NO production to support multiple gastrointestinal functions.	Arginine	51-61	nitric oxide synthase 3	Canis lupus familiaris	0-21
10770944-5	2000	Here, we identify specific arginine residues (Arg(394) and Arg(396)) in the beta-arrestin 2 C terminus that mediate beta-arrestin binding to AP-2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 independently of clathrin binding.	Arginine	27-35	transcription factor AP-2 alpha	Homo sapiens	141-145
10770944-5	2000	Here, we identify specific arginine residues (Arg(394) and Arg(396)) in the beta-arrestin 2 C terminus that mediate beta-arrestin binding to AP-2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 independently of clathrin binding.	Arginine	27-35	transcription factor AP-2 alpha	Homo sapiens	237-241
10770944-5	2000	Here, we identify specific arginine residues (Arg(394) and Arg(396)) in the beta-arrestin 2 C terminus that mediate beta-arrestin binding to AP-2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 independently of clathrin binding.	Arginine	46-49	transcription factor AP-2 alpha	Homo sapiens	141-145
10770944-5	2000	Here, we identify specific arginine residues (Arg(394) and Arg(396)) in the beta-arrestin 2 C terminus that mediate beta-arrestin binding to AP-2 and show, in vitro, that these domains in beta-arrestin 1 and 2 interact equally well with AP-2 independently of clathrin binding.	Arginine	59-62	transcription factor AP-2 alpha	Homo sapiens	141-145
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	12-15	serpin family B member 6	Homo sapiens	118-123
10873770-5	2000	Mutation of Arg-340/Ser-341 at the predicted P1/P1" sites within the RCL prevented the formation of complexes between SPI-3 and plasmin, uPA, or tPA, suggesting that the arginine at the P1 position was required for complex formation.	Arginine	170-178	serpin family B member 6	Homo sapiens	118-123
10972423-4	2000	A mutation in her DHAPAT complementary DNA resulted in the substitution of an arginine residue in the protein at position 211 by a histidine (R211H).	Arginine	78-86	glyceronephosphate O-acyltransferase	Homo sapiens	18-24
10749851-9	2000	Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 and ILF3 and is the site of ILF3 methylation by PRMT1.	Arginine	86-94	protein arginine methyltransferase 1	Homo sapiens	167-172
10749851-9	2000	Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 and ILF3 and is the site of ILF3 methylation by PRMT1.	Arginine	86-94	protein arginine methyltransferase 1	Homo sapiens	221-226
10842059-3	2000	In a two-hybrid screen for additional components of the pathway using the Drosophila I-kappaB protein Cactus as a bait, we isolated a novel coiled-coil protein with N-terminal Arg-Asp (RD)- like motifs that we call Cactin.	Arginine	176-179	cactin	Drosophila melanogaster	215-221
10748127-4	2000	The asymmetrical dimethylation of arginine residues within these RG repeats dramatically reduces the binding of the SH3 domains of p59(fyn) and phospholipase Cgamma-1, but has no effect on their binding to the WW domain of FBP30.	Arginine	34-42	HLA complex P5B	Homo sapiens	131-134
10814707-4	2000	RERE also contains arginine-aspartic acid (RD) dipeptide repeats and putative nuclear localization signal sequences, but no polyglutamine tracts.	Arginine	19-27	arginine-glutamic acid dipeptide repeats	Homo sapiens	0-4
10747882-11	2000	Trypsin cleaved Vph1p at arginine 53.	Arginine	25-33	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	16-21
10799524-2	2000	BNIP-2 contains many arginine residues at the carboxyl terminus, which includes the region of homology to the noncatalytic domain of Cdc42GAP, termed BNIP-2 and Cdc42GAP homology (BCH) domain.	Arginine	21-29	Rho GTPase activating protein 1	Homo sapiens	133-141
10791873-8	2000	Aminoglycoside-arginine conjugates inhibit HIV replication by interrupting the early phase of the virus life cycle, namely virus binding to CD4 cells and interaction with CXCR4.	Arginine	15-23	C-X-C motif chemokine receptor 4	Homo sapiens	171-176
10773347-3	2000	The Arg-Gly-Asp sequence (RGD), is recognized by many integrins, including integrin alphavbeta3 (CD51/61).	Arginine	4-7	integrin subunit alpha V	Homo sapiens	75-95
10773347-4	2000	Coxsackievirus A9 (CAV-9), a human pathogen that has an Arg-Gly-Asp sequence in the VP1 capsid protein, has been known to be one of the many viruses that utilise integrin alphavbeta3 as a receptor.	Arginine	56-59	integrin subunit alpha V	Homo sapiens	162-182
10806224-9	2000	Deletion experiments showed that the N-terminal glycine- and arginine-rich region is necessary and sufficient to target AtFbr1 to the nucleolus.	Arginine	61-69	fibrillarin 1	Arabidopsis thaliana	120-126
10788626-3	2000	In non-primate GHs, His(170) replaces the homologous Asp(171), producing a repulsive interaction with Arg(43) of the primate receptor which was believed to reduce the attraction of non-primate GH for the human GH receptor, thus providing species specificity.	Arginine	102-105	growth hormone receptor	Homo sapiens	210-221
10885579-5	2000	Studies of the crystal structure of endostatin have shown a compact globular fold, with one face particularly rich in arginine residues acting as a heparin-binding epitope.	Arginine	118-126	collagen, type XVIII, alpha 1	Mus musculus	36-46
10877506-5	2000	These neutrophils are chemotactically attracted and activated there by synergistic action of chemokines, IL-8 and Gro-alpha released by stimulated keratinocytes, and particularly by C5a/C5a des arg produced via the alternative complement pathway activation.	Arginine	194-197	C-X-C motif chemokine ligand 1	Homo sapiens	114-123
10706884-0	2000	A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation.	Arginine	29-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-37
10706884-3	2000	We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)(q22;q11.2) and a t(1;12)(q25;p13), which has the remarkable feature to differentiate to mature eosinophils in culture with all-trans retinoic acid and cytokines.	Arginine	41-44	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	46-49
10692432-2	2000	Botulinum neurotoxin (BoNT) E, a protease that cleaves SNAP25 at Arg(180)-Ile(181), completely inhibits this late step in PC12 cell membranes, whereas BoNT A, which cleaves SNAP25 at Gln(197)-Arg(198), is only partially inhibitory.	Arginine	65-68	synaptosome associated protein 25	Rattus norvegicus	55-61
10692432-2	2000	Botulinum neurotoxin (BoNT) E, a protease that cleaves SNAP25 at Arg(180)-Ile(181), completely inhibits this late step in PC12 cell membranes, whereas BoNT A, which cleaves SNAP25 at Gln(197)-Arg(198), is only partially inhibitory.	Arginine	192-195	synaptosome associated protein 25	Rattus norvegicus	55-61
10710369-10	2000	Additionally, the conversion of radiolabeled L-arginine to L-citrulline NOS activity demonstrated a consistent amount of activity present in the endothelium-denuded smooth muscle preparations that was reduced by 99% with an NOS 1 specific inhibitor.	Arginine	45-55	nitric oxide synthase 1	Bos taurus	224-229
10715402-1	2000	Mutation of arginin to glutamine in codon 555 (R 555 Q) in kerato-epithelin was recently reported in four blood-related patients with Reis-Bucklers corneal dystrophy.Case: A 42-year-old female has had photophobia with decreasing vison since the age of 20 years.	Arginine	12-19	transforming growth factor beta induced	Homo sapiens	59-75
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	48-51	vitamin D receptor	Homo sapiens	63-67
10707958-2	2000	Employing mutational analysis, we characterized Arg-18/Arg-22, hVDR residues immediately N-terminal of the first DNA binding zinc finger, as vital for contact with human basal transcription factor IIB (TFIIB).	Arginine	55-58	vitamin D receptor	Homo sapiens	63-67
10707958-6	2000	It is concluded that the functioning of positively charged Arg-18/Arg-22 as part of an hVDR docking site for TFIIB is influenced by the composition of the adjacent polymorphic N terminus.	Arginine	59-62	vitamin D receptor	Homo sapiens	87-91
10707958-6	2000	It is concluded that the functioning of positively charged Arg-18/Arg-22 as part of an hVDR docking site for TFIIB is influenced by the composition of the adjacent polymorphic N terminus.	Arginine	66-69	vitamin D receptor	Homo sapiens	87-91
10778740-8	2000	Although the functional C-terminal truncations disrupt the ATP-binding and active sites of Cdk2, reporter gene repression mediated by these truncated proteins is apparently due to phosphorylation of Pho4p, since a gene in which the essential lysine codon at position 33 was converted to an arginine codon does not complement the chromosomal gene disruption.	Arginine	290-298	phosphate-sensing transcription factor PHO4	Saccharomyces cerevisiae S288C	199-204
10787060-0	2000	Arginine degradation by arginase in mitochondria of soybean seedling cotyledons.	Arginine	0-8	arginase	Glycine max	24-32
10787060-9	2000	At least 30% of L-[guanido-14C]Arg taken up by mitochondria was degraded by arginase in seedling cotyledons, while little or no degradation was detected in mitochondria from developing embryos, even though the Arg uptake level was similar in both mitochondrial preparations.	Arginine	31-34	arginase	Glycine max	76-84
24040099-10	2013	Our findings indicate that accumulation of L-Arg and Cit and cell growth in colorectal cancer tissues is associated with over-expression of the Arg transporter gene CAT-1.	Arginine	43-48	transient receptor potential cation channel subfamily V member 6	Homo sapiens	165-170
24579556-9	2013	Direct sequencing detected a recurrent heterozygous missense c.1877A &gt; G mutation in exon 14 of the TGFBI gene, resulting in substitution of histidine with arginine (p.H626R).	Arginine	159-167	transforming growth factor beta induced	Homo sapiens	103-108
10774743-5	2000	The modification of GDH by the arginine-specific dicarbonyl reagent phenylglyoxal was also examined with the view that arginine residues might play a general role in the binding of coenzyme throughout the family of pyridine nucleotide-dependent dehydrogenases.	Arginine	31-39	Glu/Leu/Phe/Val dehydrogenase	Saccharolobus solfataricus	20-23
10774743-10	2000	The above results suggests that the phenylglyoxal-modified arginine residues are not located at the catalytic site and the inactivation of GDH by phenylglyoxal might be due to a steric hindrance or a conformational change affected by the interaction of the enzyme with its inhibitor.	Arginine	59-67	Glu/Leu/Phe/Val dehydrogenase	Saccharolobus solfataricus	139-142
23673479-8	2013	After stratification for genders, the following combinations of genotype were found to be significant in male: XPD Lys/Gln+XPC Lys/Lys (OR = 1.87; p = 0.03), XRCC1 Arg/Gln+XPC Lys/Lys (OR = 4.52; p = 0.0007), XRCC1 Arg/Gln+XPC Lys/Gln (OR = 5.44; p &lt; 0.0001).	Arginine	164-167	X-ray repair cross complementing 1	Homo sapiens	158-163
10652320-10	2000	Interestingly, further study suggested that certain basic residues of this site, particularly Arg(165) and Lys(169), play key roles in factor Va and/or prothrombin recognition by FXa in prothrombinase.	Arginine	94-97	coagulation factor X	Homo sapiens	179-182
10652320-10	2000	Interestingly, further study suggested that certain basic residues of this site, particularly Arg(165) and Lys(169), play key roles in factor Va and/or prothrombin recognition by FXa in prothrombinase.	Arginine	94-97	coagulation factor X	Homo sapiens	186-200
23825054-9	2013	The effects of rpl1b-Delta and of either paromomycin or tRNA(Arg(ICG)) on CGA decoding are additive, suggesting that the rpl1b-Delta mutant suppresses CGA inhibition by means other than increased acceptance of tRNA(Arg(ICG)).	Arginine	61-64	ribosomal 60S subunit protein L1B	Saccharomyces cerevisiae S288C	121-126
10642536-4	2000	We also mapped residues 518-522 (Arg-Ser(519)-Trp-Thr(521)-Phe) in hIL-9Ralpha and helix I of 14-3-3zeta as being important for interaction.	Arginine	33-36	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	94-104
23825054-9	2013	The effects of rpl1b-Delta and of either paromomycin or tRNA(Arg(ICG)) on CGA decoding are additive, suggesting that the rpl1b-Delta mutant suppresses CGA inhibition by means other than increased acceptance of tRNA(Arg(ICG)).	Arginine	215-218	ribosomal 60S subunit protein L1B	Saccharomyces cerevisiae S288C	121-126
10655512-4	2000	We found that an arginine-restricted diet substantially reduces plasma ornithine levels and completely prevents retinal degeneration in Oat(-/-).	Arginine	17-25	ornithine aminotransferase	Mus musculus	136-139
10709858-3	2000	In this context, it is notable that cell types that do not have a complete urea cycle often possess the urea cycle enzymes argininosuccinate synthase and argininosuccinate lyase; together, these enzymes confer the ability to regenerate arginine from the NOS product, L-citrulline.	Arginine	236-244	argininosuccinate lyase	Homo sapiens	154-177
23707382-6	2013	CLK1 induces a unique gel shift in SRSF1 that is not the result of enhanced Arg-Ser phosphorylation but rather is the direct result of the phosphorylation of several Ser-Pro dipeptides.	Arginine	76-79	serine and arginine rich splicing factor 1	Homo sapiens	35-40
23977297-1	2013	Protein arginine methyltransferase 1 (PRMT1), the major arginine asymmetric dimethylation enzyme in mammals, is emerging as a potential drug target for cancer and cardiovascular disease.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
10709858-4	2000	Herein, the authors summarize evidence to support the view that argininosuccinate synthase and argininosuccinate lyase function in an arginine-citrulline cycle, providing a ready source of arginine for high-output NO synthesis.	Arginine	134-142	argininosuccinate lyase	Homo sapiens	95-118
10709858-4	2000	Herein, the authors summarize evidence to support the view that argininosuccinate synthase and argininosuccinate lyase function in an arginine-citrulline cycle, providing a ready source of arginine for high-output NO synthesis.	Arginine	189-197	argininosuccinate lyase	Homo sapiens	95-118
23977297-4	2013	In this study, we present a theoretical study on PRMT1 catalyzed arginine dimethylation by employing molecular dynamics (MD) simulation and quantum mechanics/molecular mechanics (QM/MM) calculation.	Arginine	65-73	protein arginine methyltransferase 1	Homo sapiens	49-54
23579026-0	2013	Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes.	Arginine	38-46	2,4-dienoyl-CoA reductase 1	Homo sapiens	82-87
10627484-5	2000	Substitution of His for Arg at this site resulted in the blockage of Factor Xa cleavage, forming a dysfunctional molecule.	Arginine	24-27	coagulation factor X	Homo sapiens	69-78
23579026-3	2013	Arg residues are particularly susceptible to MGO glycation and are essential for binding NADP(+) in several enzymes that generate NADPH, a coenzyme for many critical metabolic and antioxidant enzymes.	Arginine	0-3	2,4-dienoyl-CoA reductase 1	Homo sapiens	130-135
23311922-6	2013	EprS preferred to cleave substrates that terminated with arginine or lysine residues.	Arginine	57-65	glutamyl-prolyl-tRNA synthetase 1	Homo sapiens	0-4
10961931-6	2000	CARM1 also methylates specific arginine residues in the N-terminal tail of histone H3 in vitro.	Arginine	31-39	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
23253603-8	2013	Molecular modeling of the TPK1-CPK3 interaction domain provided mechanistic insights into TPK1 stress-regulated phosphorylation responses and pinpointed two arginine residues in the N-terminal 14-3-3 binding motif in TPK1 critical for kinase interaction.	Arginine	157-165	Outward rectifying potassium channel protein	Arabidopsis thaliana	26-30
10602480-7	1999	The interaction domain within Dlk was mapped to an arginine-rich region between residues 338 - 417, rather than to the leucine zipper.	Arginine	51-59	death associated protein kinase 3	Homo sapiens	30-33
23785515-7	2013	The adaptive changes in liver function were accompanied by an increased expression of genes involved in arginine metabolism (Asl, Got1, Gpt2, Glud1, Arg1, and Arg2) and transport (Slc25a13, Slc25a15, and Slc3a2), whereas no such changes were found in the intestine.	Arginine	104-112	glutamic-oxaloacetic transaminase 1, soluble	Mus musculus	130-134
10591674-0	1999	Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression.	Arginine	24-27	low density lipoprotein receptor	Mus musculus	101-113
23785515-7	2013	The adaptive changes in liver function were accompanied by an increased expression of genes involved in arginine metabolism (Asl, Got1, Gpt2, Glud1, Arg1, and Arg2) and transport (Slc25a13, Slc25a15, and Slc3a2), whereas no such changes were found in the intestine.	Arginine	104-112	glutamate dehydrogenase 1	Mus musculus	142-147
10615005-2	1999	We have now determined the kinetic parameters for hydrolysis by human and porcine tissue kallikrein, hK1 and pK1, respectively (Berg et al., 1992) of two series of intramolecularly quenched fluorogenic peptides having the sequences that flank the scissile Arg-Ser or Met-Lys bond in human and bovine kininogen.	Arginine	256-259	prokineticin 1	Homo sapiens	109-112
23785515-7	2013	The adaptive changes in liver function were accompanied by an increased expression of genes involved in arginine metabolism (Asl, Got1, Gpt2, Glud1, Arg1, and Arg2) and transport (Slc25a13, Slc25a15, and Slc3a2), whereas no such changes were found in the intestine.	Arginine	104-112	arginase type II	Mus musculus	159-163
23785729-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
10556781-7	1999	ARG-40 showed high homology to cytochrome b, while ARG-33 was novel.	Arginine	0-3	cytochrome b, mitochondrial	Rattus norvegicus	31-43
23741768-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
10525102-6	1999	Compared with the published sequence for the alpha(1B)-adrenergic receptor, we found one amino acid addition in exon 2 at position 368 (Arg) and one substitution (Arg371Gly) in all subjects.	Arginine	136-139	adrenoceptor alpha 1B	Homo sapiens	45-74
23516040-4	2013	The central region in apoA-I sequence is suggested to influence the proper positioning of cholesterol molecule toward LCAT active center with major contribution of arginine residue(s).	Arginine	164-172	lecithin-cholesterol acyltransferase	Homo sapiens	118-122
10531383-6	1999	Mutation of conserved phospholipid binding residues tryptophan 26 and arginine 29, generates Gab1 proteins with decreased phosphatidylinositol 3,4,5-trisphosphate binding, decreased localization at sites of cell-cell contact, and reduced ability to rescue Met-dependent morphogenesis.	Arginine	70-78	GRB2 associated binding protein 1	Homo sapiens	93-97
23599266-2	2013	Missense mutations of some arginine residues at the surface of alpha-TTP cause severe vitamin E deficiency in humans, but the role of these residues is unclear.	Arginine	27-35	alpha tocopherol transfer protein	Homo sapiens	63-72
23507581-5	2013	To characterize the interaction between the homologous Arg of rat nNOS (R753) and murine iNOS (R530) with CaM, the Arg was mutated to Ala and, in iNOS, to Glu.	Arginine	55-58	nitric oxide synthase 1	Rattus norvegicus	66-70
23778535-3	2013	Btf and TRAP150 are serine-arginine-rich (SR) proteins with significant sequence similarity, but the extent of their functional overlap is not yet clear.	Arginine	27-35	BCL2 associated transcription factor 1	Homo sapiens	0-3
23420846-1	2013	The minimal proton pumping machinery of the Arabidopsis thaliana P-type plasma membrane H(+)-ATPase isoform 2 (AHA2) consists of an aspartate residue serving as key proton donor/acceptor (Asp-684) and an arginine residue controlling the pKa of the aspartate.	Arginine	204-212	H[+]-ATPase 2	Arabidopsis thaliana	111-115
23480827-6	2013	FXa generation assays and Western blotting, used to monitor rates of FVIIIa inactivation and proteolysis at the primary cleavage site in the cofactor (Arg(336)), respectively, showed marked rate reductions relative to WT for the Lys39Ala, Lys37-Lys38-Lys39/Pro-Gln-Glu, Arg67Ala, and Arg74Ala variants.	Arginine	151-154	coagulation factor X	Homo sapiens	0-3
23435230-5	2013	The complex structure of vIRF-1 DBD reveals interactions with the DNA backbone and the positioning of two arginines for specific recognition in the major grove.	Arginine	106-115	K9	Human gammaherpesvirus 8	25-31
23461848-10	2013	Both procaine and lidocaine significantly suppressed l-arginine uptake in BAEC stimulated with either bradykinin/acetylcholine or interleukin-1beta/lipopolysaccharide.	Arginine	53-63	kininogen 1	Bos taurus	102-112
22886620-0	2013	The protection by heme oxygenase-1 induction against thioacetamide-induced liver toxicity is associated with changes in arginine and asymmetric dimethylarginine.	Arginine	120-128	heme oxygenase 1	Rattus norvegicus	18-34
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Arginine	206-214	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	49-54
23313743-5	2013	Substrate specificity analysis revealed that the rMBSP specifically cleaved substrates at the carboxyl side of lysine residue which differed from native MBSP that cleaved substrates at the carboxyl side of arginine and lysine residues.	Arginine	206-214	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	50-54
23682531-3	2013	Novel COL1A1 nonsense mutation (c. 3202 C--&gt;T), a C to T transition at position 3,203, resulting in arginine to stop codon at codon 1026 (R102 6X) mutation in exon 42 was found, and this is the first case reported in the literature.	Arginine	103-111	collagen type I alpha 1 chain	Homo sapiens	6-12
23174505-1	2013	The capsid protein (CP) of duck circovirus (DuCV) is the major immunogenic protein and has a high proportion of arginine residues concentrated at the N terminus of the protein, which inhibits efficient mRNA translation in prokaryotic expression systems.	Arginine	112-120	capsid protein	Duck circovirus	4-18
23174505-1	2013	The capsid protein (CP) of duck circovirus (DuCV) is the major immunogenic protein and has a high proportion of arginine residues concentrated at the N terminus of the protein, which inhibits efficient mRNA translation in prokaryotic expression systems.	Arginine	112-120	capsid protein	Duck circovirus	20-22
23514754-3	2013	The cell seeding density and surface modification of chitosan with Arg-Gly-Asp-containing peptide had an influence on the sizes of ASC spheroids.	Arginine	67-70	PYD and CARD domain containing	Rattus norvegicus	131-134
23284103-8	2013	Indeed, murine BMP15 activity was restored when specific residues through this region (Pro(329)/Tyr(330)) were replaced with the corresponding residues (Arg(329)/Asp(330)) from human BMP15.	Arginine	153-156	bone morphogenetic protein 15	Mus musculus	15-20
23097400-11	2013	Arginine, His, and Leu are examples of AA that can promote insulin secretion, and in turn, insulin can increase fetal IGF-I concentrations.	Arginine	0-8	LOC105613195	Ovis aries	59-66
23214442-6	2013	With a single targeted arginine, PRMT1 catalyzed the dimethylation in a semiprocessive manner.	Arginine	23-31	protein arginine methyltransferase 1	Homo sapiens	33-38
24175791-6	2013	RESULTS: After adjustment for sex and age, individuals with the XRCC1 399Gln/Gln (OR=1.96; 95%CI:1.02- 3.78; p=0.04) and Arg/Gln (OR=1.87; 95%CI:1.29-2.71; p=0.001) genotype variants demonstrated a significantly increased risk of nasopharyngeal carcinoma compared with those having the wild-type Arg/Arg genotype.	Arginine	296-299	X-ray repair cross complementing 1	Homo sapiens	64-69
24175791-6	2013	RESULTS: After adjustment for sex and age, individuals with the XRCC1 399Gln/Gln (OR=1.96; 95%CI:1.02- 3.78; p=0.04) and Arg/Gln (OR=1.87; 95%CI:1.29-2.71; p=0.001) genotype variants demonstrated a significantly increased risk of nasopharyngeal carcinoma compared with those having the wild-type Arg/Arg genotype.	Arginine	296-299	X-ray repair cross complementing 1	Homo sapiens	64-69
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Arginine	192-195	KRAS proto-oncogene, GTPase	Homo sapiens	66-69
24372240-7	2013	The protein-protein docking showed that the aminoacid residues of NS3 which were interacting with NRBP were found to be Ala 325, Asp 324, Phe 326, Asp 335, Glu 336, Glu 328, Asp 485, Gln 478, Arg 459, Gly 446 and Leu 480.	Arginine	192-195	nuclear receptor binding protein 1	Homo sapiens	98-102
23182424-4	2013	We constructed two variants of hDMC1 altering the conserved lysine residue of the Walker A motif to arginine (hDMC1(K132R)) or alanine (hDMC1(K132A)).	Arginine	100-108	DNA meiotic recombinase 1	Homo sapiens	31-36
23867994-6	2013	This C-to-T transition, mapping to position 334 in the cDNA of the alpha-gal A gene, was a missense mutation predicting a substitution of arginine to cysteine (p.R112C), which disrupts the normal activity of alpha-gal A enzyme.	Arginine	138-146	galactosidase alpha	Homo sapiens	67-78
23867994-6	2013	This C-to-T transition, mapping to position 334 in the cDNA of the alpha-gal A gene, was a missense mutation predicting a substitution of arginine to cysteine (p.R112C), which disrupts the normal activity of alpha-gal A enzyme.	Arginine	138-146	galactosidase alpha	Homo sapiens	208-219
22889511-7	2013	L-NAME treatment suppressed Arg effects on: 1) nitrite and c-GMP content; 2) glycogen synthesis and glucose uptake; 3) basal and insulin-stimulated p-Akt (Ser(473)), total and p-AMPK-alpha and ACC, and nNOS expression.	Arginine	28-31	nitric oxide synthase 1	Rattus norvegicus	202-206
10514523-7	1999	We further revealed the role of two charged amino acid residues in the transmembrane region, namely arginine and glutamic acid, in PIR-A function and its association with the above subunits.	Arginine	100-108	pirin	Rattus norvegicus	131-134
22983827-6	2013	Similarly, those carrying XRCC1 399 Gln/Gln genotypes had 0.44-fold the risk of death than those with the Arg/Arg genotype.	Arginine	106-109	X-ray repair cross complementing 1	Homo sapiens	26-31
10604529-3	1999	Either HIST or 5-HT potentiated (likely involving the H1 and 5-HT2 receptors, respectively) the activating effect of BK on kininase I (K1), thus increasing the availability of L-arginine for the synthesis of NO.	Arginine	176-186	carboxypeptidase N subunit 1	Homo sapiens	123-133
10514459-5	1999	Within the 5-lipoxygenase protein is a sequence (Arg(638)-Lys(655)) that closely resembles a bipartite nuclear localization signal.	Arginine	49-52	arachidonate 5-lipoxygenase	Mus musculus	11-25
22983827-6	2013	Similarly, those carrying XRCC1 399 Gln/Gln genotypes had 0.44-fold the risk of death than those with the Arg/Arg genotype.	Arginine	110-113	X-ray repair cross complementing 1	Homo sapiens	26-31
22858580-7	2013	Analysis of the cgUbiquitin C-terminus by carboxypeptidase B treatment and comparison of the retention times revealed that cgUbiquitin lacks the terminal Gly-Gly doublet and ends in an C-terminal Arg residue which might be related to antimicrobial activity.	Arginine	196-199	ubiquitin-60S ribosomal protein L40	Crassostrea gigas	123-134
10514274-3	1999	Studies have shown that the binding of arginine and arginine derivatives induces a conformational change of the TAR RNA at the Tat-binding site.	Arginine	39-47	Tat	Human immunodeficiency virus 1	127-130
10514274-3	1999	Studies have shown that the binding of arginine and arginine derivatives induces a conformational change of the TAR RNA at the Tat-binding site.	Arginine	52-60	Tat	Human immunodeficiency virus 1	127-130
10515589-3	1999	We found three distinct characteristics of OGG1 in SAMPs: (i) low activity (10-40% of the SAMRI enzyme in all organs and ages observed), (ii) thermolability, and (iii) mutation from Arg (CGG) in SAMR1 to Trp (TGG) at codon 304.	Arginine	182-185	8-oxoguanine DNA-glycosylase 1	Mus musculus	43-47
23122700-3	2013	Arginase-2 competes with eNOS for l-arginine and counteracts the NOS-dependent relaxation in umbilical vessels from normal pregnancies.	Arginine	34-44	arginase 2	Homo sapiens	0-10
23555621-8	2013	Finally, a predominant endoproteolytic peptidase specificity for Arg/Lys or Leu/Phe residues in the P(1) position of the scissile bond was found for the TAP-independent ligands.	Arginine	65-68	nuclear RNA export factor 1	Homo sapiens	153-156
10629852-0	1999	[Role of L-arginine--endogenous NOS inhibitors--endothelin-1 pathway for the vascular remodelling].	Arginine	9-19	endothelin-1	Oryctolagus cuniculus	48-60
23544150-2	2013	This phenotype requires mutations at nts 319 and 321; these mutations result in Arg to Leu and Ser to Cys changes at positions 87 and 88 respectively in the viral methyl transferase, nsP1.	Arginine	80-83	SH2 domain containing 3A	Homo sapiens	183-187
10629852-2	1999	We describe herein the role of L-arginine-endogenous NOS inhibitors-endothelin-1 pathway for the vascular remodelling after endothelial denudation of the rabbit carotid artery.	Arginine	31-41	endothelin-1	Oryctolagus cuniculus	68-80
10629852-7	1999	These results strongly suggest that the L-arginine--endogenous NOS inhibitors--endothelin-1 pathway plays an active role for vascular remodelling.	Arginine	40-50	endothelin-1	Oryctolagus cuniculus	79-91
10530926-7	1999	Further exploration of the SAR with 2-amino-5-(heterocyclylthio)pentanoic acids (synthesised from 2-(Boc-amino)-5-bromopentanoic acid t-butyl ester), with N-(4-aminobutyl)thiourea and with 2-(4-aminobutylamino)-4,5-dihydrothiazole enabled refinement of our previous model for binding of the substrate, L-arginine, and the inhibitors to NOS.	Arginine	302-312	sarcosine dehydrogenase	Homo sapiens	27-30
23469136-8	2013	The results are consistent with a cation-pi interaction between the adenine of AdA and a conserved arginine within the IBC alpha-domain contributing to closure of the IBC.	Arginine	99-107	adenosine deaminase	Homo sapiens	79-82
10400690-4	1999	Phosphorylated recombinant wild-type nNOS at Ser847 (approximately 0.5 mol of phosphate incorporation into nNOS) exhibited a 30% decrease of Vmax with little change of both the Km for L-arginine and Kact for CaM relative to unphosphorylated enzyme.	Arginine	184-194	nitric oxide synthase 1	Rattus norvegicus	37-41
23516639-8	2013	The rs7775 SNP in exon 6 of SFRP3 gene that codes for either arginine or glycine exhibited very strong association with breast cancer, even after Bonferroni"s correction.	Arginine	61-69	frizzled related protein	Homo sapiens	28-33
10383458-2	1999	Purification and sequence analysis of ASP from human sera have revealed that ASP is identical to the complement C3-derived activation peptide C3ades-Arg.	Arginine	149-152	complement C3	Homo sapiens	101-114
23405163-8	2013	Notably, perilipin PKA-site 5 and HSL-serine 660 feature two arginine residues upstream from the phospho-acceptor site, which confers high affinity for PKA, whereas perilipin PKA-site 6 and HSL-serine 563 feature only a single arginine.	Arginine	61-69	lipase E, hormone sensitive type	Homo sapiens	34-37
10381509-3	1999	We found that chemically Arg-modified alpha2AP, which lacked plasmin-inhibitory activity, competed effectively with native alpha2AP for becoming cross-linked to fibrin and as a consequence, enhanced fibrinolysis.	Arginine	25-28	serpin family F member 2	Homo sapiens	38-46
10381509-3	1999	We found that chemically Arg-modified alpha2AP, which lacked plasmin-inhibitory activity, competed effectively with native alpha2AP for becoming cross-linked to fibrin and as a consequence, enhanced fibrinolysis.	Arginine	25-28	serpin family F member 2	Homo sapiens	123-131
23405163-8	2013	Notably, perilipin PKA-site 5 and HSL-serine 660 feature two arginine residues upstream from the phospho-acceptor site, which confers high affinity for PKA, whereas perilipin PKA-site 6 and HSL-serine 563 feature only a single arginine.	Arginine	227-235	lipase E, hormone sensitive type	Homo sapiens	34-37
23405163-8	2013	Notably, perilipin PKA-site 5 and HSL-serine 660 feature two arginine residues upstream from the phospho-acceptor site, which confers high affinity for PKA, whereas perilipin PKA-site 6 and HSL-serine 563 feature only a single arginine.	Arginine	227-235	lipase E, hormone sensitive type	Homo sapiens	190-193
23285494-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
10383917-8	1999	In particular, CYP2C19, CYP2B6, CYP2C9-Arg, CYP2D6-Val, and CYP3A4 all showed relatively high activity.	Arginine	39-42	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	15-22
22531684-1	2012	Argininosuccinate lyase (ASL) is an important enzyme in the hepatic urea cycle, and catalyzes the reversible reaction of argininosuccinate to arginine and fumarate.	Arginine	142-150	argininosuccinate lyase	Homo sapiens	0-23
10364300-4	1999	The arginine substitution at position 11 of the V3 loop uniformly caused the loss of infectivity in HOS-CD4-CCR5 cells, indicating that position 11 is critical for utilization of CCR5.	Arginine	4-12	C-C motif chemokine receptor 5	Homo sapiens	108-112
10364300-4	1999	The arginine substitution at position 11 of the V3 loop uniformly caused the loss of infectivity in HOS-CD4-CCR5 cells, indicating that position 11 is critical for utilization of CCR5.	Arginine	4-12	C-C motif chemokine receptor 5	Homo sapiens	179-183
10364300-5	1999	CXCR4 usage was conferred by a minimum of two arginine substitutions, regardless of combination, whereas arginine substitutions at position 8 and 11 were required for T-cell line tropism.	Arginine	46-54	C-X-C motif chemokine receptor 4	Homo sapiens	0-5
22531684-1	2012	Argininosuccinate lyase (ASL) is an important enzyme in the hepatic urea cycle, and catalyzes the reversible reaction of argininosuccinate to arginine and fumarate.	Arginine	142-150	argininosuccinate lyase	Homo sapiens	25-28
23042250-9	2012	Furthermore, the effect of AtGRP7 on these AS events was abrogated by mutation of a single arginine that is required for its RNA-binding activity.	Arginine	91-99	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	27-33
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Arginine	18-27	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	80-85
10559906-4	1999	Between these two arginines, a conservative change of isoleucine residue 229 in GIRK4 to the corresponding leucine found in IRK1 strengthens GIRK4-PtdIns(4,5)P2 interactions, eliminating the need for extra gating molecules.	Arginine	18-27	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	141-146
23048028-0	2012	A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.	Arginine	19-27	signal recognition particle 68	Homo sapiens	161-166
10458643-11	1999	Inhibition of NO-synthase by L-NNA significantly delayed ulcer healing and reversed the CCK-8 induced acceleration of ulcer healing, hyperemia at the ulcer margin and luminal NO release, and these effects were restored by the addition to L-NNA of L-arginine but not D-arginine.	Arginine	247-257	cholecystokinin	Rattus norvegicus	88-91
10362520-4	1999	2-D gel electrophoresis of RNase-treated yeast extracts allowed us to tentatively identify the glycine- and arginine-rich (GAR) domain-containing proteins Gar1, Nop1, Sbp1, and Npl3 as major methyl-acceptors based on their known isoelectric points and apparent molecular weights.	Arginine	108-116	Sbp1p	Saccharomyces cerevisiae S288C	167-171
10362520-4	1999	2-D gel electrophoresis of RNase-treated yeast extracts allowed us to tentatively identify the glycine- and arginine-rich (GAR) domain-containing proteins Gar1, Nop1, Sbp1, and Npl3 as major methyl-acceptors based on their known isoelectric points and apparent molecular weights.	Arginine	108-116	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	177-181
10333501-0	1999	CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages.	Arginine	14-24	catalase, gene 2 L homeolog	Xenopus laevis	0-4
10333501-6	1999	Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased l-arginine uptake, our data demonstrate that CAT2 mediates the l-arginine transport that is required for the raised NO production in activated J774 macrophages.	Arginine	107-117	catalase, gene 2 L homeolog	Xenopus laevis	50-54
10333501-6	1999	Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased l-arginine uptake, our data demonstrate that CAT2 mediates the l-arginine transport that is required for the raised NO production in activated J774 macrophages.	Arginine	107-117	catalase, gene 2 L homeolog	Xenopus laevis	152-156
10333501-6	1999	Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased l-arginine uptake, our data demonstrate that CAT2 mediates the l-arginine transport that is required for the raised NO production in activated J774 macrophages.	Arginine	170-180	catalase, gene 2 L homeolog	Xenopus laevis	50-54
10333501-6	1999	Together with expression studies documenting that CAT2 mRNA and protein levels are elevated with increased l-arginine uptake, our data demonstrate that CAT2 mediates the l-arginine transport that is required for the raised NO production in activated J774 macrophages.	Arginine	170-180	catalase, gene 2 L homeolog	Xenopus laevis	152-156
10330172-3	1999	We show here that TTP binding to the TNF-alpha ARE is dependent upon the integrity of both zinc fingers, since mutation of a single cysteine residue in either zinc finger to arginine severely attenuated the binding of TTP to the TNF-alpha ARE.	Arginine	174-182	zinc finger protein 36	Mus musculus	18-21
10353933-7	1999	RESULTS: We found a polymorphism for UGT1A1 in exon 1; a G--&gt;A transition at nucleotide 211 caused arginine to replace glycine at position 71 of corresponding protein product (G71R).	Arginine	102-110	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	37-43
10329662-7	1999	The transcriptional repression function of AEBP2 was completely abolished when one of the conserved histidine residues and a flanking serine residue in the middle zinc finger were replaced with an arginine residue.	Arginine	197-205	AE binding protein 2	Mus musculus	43-48
10234007-7	1999	The data revealed that a minimum length of human Cx32 including the residue Arg-215 is required for the expression of hemichannels at the cell surface and that the efficiency of hemichannel incorporation into complete channels decreased gradually with the progressive shortening of the cytoplasmic C-terminal domain.	Arginine	76-79	gap junction protein beta 1	Homo sapiens	49-53
10196197-2	1999	The C-terminal arginine-serine domain of these proteins, such as SF2/ASF, mediates protein-protein interactions and is phosphorylated in vivo.	Arginine	15-23	serine and arginine rich splicing factor 1	Homo sapiens	65-68
10196197-2	1999	The C-terminal arginine-serine domain of these proteins, such as SF2/ASF, mediates protein-protein interactions and is phosphorylated in vivo.	Arginine	15-23	serine and arginine rich splicing factor 1	Homo sapiens	69-72
10196197-7	1999	Deletion analysis mapped the phosphorylation sites to a region containing an (Arg-Ser)8 repeat beginning at residue 204, and far-Western analysis showed that the region is required for binding of SRPKs to SF2/ASF.	Arginine	78-81	serine and arginine rich splicing factor 1	Homo sapiens	205-208
10198214-5	1999	H4B+ CODiNOS bound arginine, gave a stable ferrous carbonyl adduct, and was exclusively dimeric.	Arginine	19-27	H4 clustered histone 4	Homo sapiens	0-3
10198214-6	1999	The H4B cofactor content of this species was only one per dimer yet this was sufficient to form two competent arginine binding sites as determined by optical stoichiometric titrations.	Arginine	110-118	H4 clustered histone 4	Homo sapiens	4-7
10319416-3	1999	Recently, a mutation from arginine (Arg) to stop-codon at codon 1066 in the cMOAT gene has been reported in one Caucasian patient with DJS.	Arginine	26-34	ATP binding cassette subfamily C member 2	Homo sapiens	76-81
10319416-3	1999	Recently, a mutation from arginine (Arg) to stop-codon at codon 1066 in the cMOAT gene has been reported in one Caucasian patient with DJS.	Arginine	36-39	ATP binding cassette subfamily C member 2	Homo sapiens	76-81
10329202-2	1999	We analysed the MYH7 gene in three generations of a family with one borderline and four clinically verified cases of hypertrophic cardiomyopathy, and identified a mutation in exon 7 changing the 190 arginine residue into a threonine residue.	Arginine	199-207	myosin heavy chain 7	Homo sapiens	16-20
10085124-12	1999	In contrast, all three previously known catalytic residues, as well as one additional essential arginine, Arg-566 in cPLA2alpha, are conserved in both new enzyme sequences.	Arginine	96-104	phospholipase A2 group IVA	Homo sapiens	117-127
10085124-12	1999	In contrast, all three previously known catalytic residues, as well as one additional essential arginine, Arg-566 in cPLA2alpha, are conserved in both new enzyme sequences.	Arginine	106-109	phospholipase A2 group IVA	Homo sapiens	117-127
10090730-4	1999	Like the latter, RSF1 comprises an amino-terminal RRM-type RNA-binding domain, whereas its carboxy-terminal part is enriched in glycine (G), arginine (R), and serine (S) residues (GRS domain).	Arginine	141-149	Repressor splicing factor 1	Drosophila melanogaster	17-21
10037735-10	1999	The label has now been localized to arginine residues within the cyanogen bromide fragment-(341-380) that contains the primary heparin-binding site on vitronectin.	Arginine	36-44	vitronectin	Homo sapiens	151-162
10195287-4	1999	In contrast, we show here that conversion of this aspartate to arginine abolished the catalytic activity of the Fer protein-tyrosine kinase when expressed either in mammalian cells or in bacteria.	Arginine	63-71	FER tyrosine kinase	Homo sapiens	112-115
9930165-6	1999	RESULTS: Three affected persons were shown to have a heterozygous G--&gt;T transversion at the second nucleotide position of codon 124 (Arg--&gt;Leu) of the BIGH3 gene.	Arginine	136-139	transforming growth factor beta induced	Homo sapiens	157-162
10512537-4	1999	This complex displays an MCD spectrum dissimilar from that of the Mb derivative, possibly because of the stabilizing interaction between the azide ligand and the distal arginine of CCP (Arg 48).	Arginine	169-177	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	181-184
10512537-4	1999	This complex displays an MCD spectrum dissimilar from that of the Mb derivative, possibly because of the stabilizing interaction between the azide ligand and the distal arginine of CCP (Arg 48).	Arginine	186-189	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	181-184
9892210-3	1999	First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, but that the standard form of CD44 does not.	Arginine	77-85	CD44 molecule (Indian blood group)	Homo sapiens	45-49
9892210-4	1999	These CD44 variants bind to both the amino- and COOH-terminal portions of OPN independently of the arginine-glycine-aspartic acid sequence, suggesting that multiple domains on OPN can be bound by the CD44 variants.	Arginine	99-107	CD44 molecule (Indian blood group)	Homo sapiens	6-10
12623595-3	1999	Animal studies have demonstrated that the chronic administration of L-arginine reduces the extent of atherosclerosis and prevents xanthoma development in LDL receptor knockout mice.	Arginine	68-78	low density lipoprotein receptor	Mus musculus	154-166
9927151-11	1999	This increase in heme oxygenase-1 expression by lipopolysaccharide was prevented by the nitric oxide inhibitor N(G)-monomethyl-L-arginine which was reversed by an excess of L-arginine.	Arginine	127-137	heme oxygenase 1	Rattus norvegicus	17-33
9875848-5	1998	The unexpected recognition of the substrate, L-arginine, at the H4B site indicates that this site is poised to stabilize a positively charged pterin ring and suggests a model involving a cationic pterin radical in the catalytic cycle.	Arginine	45-55	H4 clustered histone 4	Homo sapiens	64-67
9829973-9	1998	We conclude that the S4 region in the hSlo channel is part of the voltage sensor and that only two charged amino acid residues in this region (Arg-210 and Arg-213) contribute to the gating valence of the channel.	Arginine	143-146	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	38-42
9829973-9	1998	We conclude that the S4 region in the hSlo channel is part of the voltage sensor and that only two charged amino acid residues in this region (Arg-210 and Arg-213) contribute to the gating valence of the channel.	Arginine	155-158	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	38-42
9868533-3	1998	Treatment of rat pancreatic acinar cells with cholecystokinin-octapeptide (CCK-OP) resulted in an increase in the arginine conversion to citrulline, the amount of NOx, the release of amylase, and the level of cGMP.	Arginine	114-122	cholecystokinin	Rattus norvegicus	75-78
10221600-0	1998	Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain.	Arginine	144-152	carboxypeptidase E	Mus musculus	6-24
9832147-9	1998	Treatment of the ligands by carboxypeptidase B to eliminate the C-terminus Arg considerably decreased the [Ca2+] response.	Arginine	75-78	carboxypeptidase B1	Homo sapiens	28-46
9846874-4	1998	The Cdc42GAP stabilizes both the switch I and switch II domains of Cdc42 and contributes a highly conserved arginine (Arg 305) to the active site.	Arginine	108-116	Rho GTPase activating protein 1	Homo sapiens	4-12
9846874-4	1998	The Cdc42GAP stabilizes both the switch I and switch II domains of Cdc42 and contributes a highly conserved arginine (Arg 305) to the active site.	Arginine	118-121	Rho GTPase activating protein 1	Homo sapiens	4-12
23103544-0	2012	L-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	81-85
23103544-11	2012	Under these findings, we suggest that targeting of eNOS and Nrf2 signaling by L-arginine supplementation could be used as a potential treatment method to alleviate the late diabetic complications.	Arginine	78-88	nitric oxide synthase 3	Rattus norvegicus	51-55
22989889-3	2012	When prothrombinase is assembled on synthetic phospholipid vesicles, prothrombin activation proceeds with an initial cleavage at Arg-320 yielding the catalytically active, yet effectively anticoagulant intermediate meizothrombin, which is released from the enzyme complex ~30-40% of the time.	Arginine	129-132	coagulation factor X	Homo sapiens	5-19
9883720-5	1998	Although they divide normally, abl(-/-)arg(-/-) neuroepithelial cells display gross alterations in their actin cytoskeleton.	Arginine	39-42	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	31-34
22989889-4	2012	Prothrombinase assembled on the surface of activated platelets has been shown to proceed through the inactive intermediate prethrombin-2 via an initial cleavage at Arg-271 followed by cleavage at Arg-320.	Arginine	164-167	coagulation factor X	Homo sapiens	0-14
22989889-4	2012	Prothrombinase assembled on the surface of activated platelets has been shown to proceed through the inactive intermediate prethrombin-2 via an initial cleavage at Arg-271 followed by cleavage at Arg-320.	Arginine	196-199	coagulation factor X	Homo sapiens	0-14
9822691-4	1998	hIIa-PLA2 contains 13 lysines, 2 histidines, and 10 arginines that fall into 10 clusters.	Arginine	52-61	phospholipase A2 group IIA	Homo sapiens	5-9
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	beclin 1	Homo sapiens	112-117
9765407-2	1998	We report here the expression of soluble integrin alphav beta5, which retains the ability to recognize the Ad penton base as well as vitronectin, an Arg Gly Asp (RGD)-containing extracellular matrix protein.	Arginine	149-152	vitronectin	Homo sapiens	133-144
22874569-4	2012	Deprivation of L-Arg induced EIF2S1 (eIF2alpha), MAPK8 (JNK), BCL2 (Bcl-2) phosphorylation, and displacement of BECN1 (Beclin 1) binding to BCL2, leading to autophagosome formation.	Arginine	15-20	beclin 1	Homo sapiens	119-127
22988298-1	2012	CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing.	Arginine	28-31	cyclin dependent kinase 12	Homo sapiens	0-5
9822825-3	1998	Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3.	Arginine	117-125	amino acid transporter BAP3	Saccharomyces cerevisiae S288C	183-187
9786934-3	1998	hnRNP D and nucleolin both contain canonical RNA binding domains (RBDs also called RRMs) and Arg-Gly-Gly (RGG) motifs.	Arginine	93-96	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	0-7
22988298-1	2012	CrkRS (Cdc2-related kinase, Arg/Ser), or cyclin-dependent kinase 12 (CKD12), is a serine/threonine kinase believed to coordinate transcription and RNA splicing.	Arginine	28-31	cyclin dependent kinase 12	Homo sapiens	41-67
23000409-4	2012	CPN cleaves C-terminal lysine and arginine residues from several proteins.	Arginine	34-42	carboxypeptidase N subunit 1	Homo sapiens	0-3
9765309-4	1998	Substituting Tyr-272, a proposed binding site for the toxins okadaic acid and microcystin-LR, in the beta12-beta13 loop with Trp, Phe, Asp, Arg, or Ala impaired PP1alpha inhibition by I-1 by 8-10-fold.	Arginine	140-143	serine/threonine-protein phosphatase PP1-alpha catalytic subunit	Oryctolagus cuniculus	161-169
9756741-5	1998	We applied the refolding process using the aggregation suppressor L-arginine in the renaturation of neurotrophin-3, and obtained biologically active neurotrophin-3 at high yield from the inclusion bodies.	Arginine	66-76	neurotrophin 3	Homo sapiens	100-114
22966869-0	2012	Role of arginine 29 and glutamic acid 81 interactions in the conformational stability of human chloride intracellular channel 1.	Arginine	8-16	chloride intracellular channel 1	Homo sapiens	95-127
9756741-5	1998	We applied the refolding process using the aggregation suppressor L-arginine in the renaturation of neurotrophin-3, and obtained biologically active neurotrophin-3 at high yield from the inclusion bodies.	Arginine	66-76	neurotrophin 3	Homo sapiens	149-163
9819765-5	1998	Hamster MCS also shared aa identity of 64.4% with mouse MCS and contained an Arg-Lys-Ser-Thr-rich region in the N-terminus similar to the mitochondrial targeting signal.	Arginine	77-80	sperm mitochondria-associated cysteine-rich protein	Rattus norvegicus	8-11
23050966-3	2012	IPMK was initially discovered as an essential subunit of the arginine-sensing transcription complex in budding yeast.	Arginine	61-69	inositol polyphosphate multikinase	Homo sapiens	0-4
22843684-0	2012	The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the beta2-adrenergic receptor.	Arginine	4-12	adrenoceptor beta 2	Homo sapiens	122-147
9742121-1	1998	Previously, we found that the cause of autosomal dominant selective tooth agenesis in one family is a missense mutation resulting in an arginine-to-proline substitution in the homeodomain of MSX1.	Arginine	136-144	msh homeobox 1	Homo sapiens	191-195
22843686-2	2012	Arg-164 is a conserved residue in all class A beta-lactamases and is located in the solvent-exposed Omega-loop of KPC-2.	Arginine	0-3	KPC-2	Escherichia coli	114-119
22843686-4	2012	When compared with wild type, 11 of 19 variants at position Arg-164 in KPC-2 conferred increased resistance to the oxyimino-cephalosporin, ceftazidime (minimum inhibitory concentration; 32 128 mg/liter) when expressed in Escherichia coli.	Arginine	60-63	KPC-2	Escherichia coli	71-76
10087507-5	1998	The encoded 658-residue protein (hCNT2 in the nomenclature) had the same predicted amino acid sequence as human kidney hSPNT1, except for a polymorphism at residue 75 (Arg substituted by Ser), and was 83 and 72% identical to rCNT2 and hCNT1, respectively.	Arginine	168-171	solute carrier family 28 member 2	Homo sapiens	33-38
22980328-3	2012	Accumulated intracellular citrulline is thought to fuel arginine synthesis catalyzed by argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl), which would lead to abundant NO production.	Arginine	56-64	argininosuccinate lyase	Homo sapiens	126-149
22980328-3	2012	Accumulated intracellular citrulline is thought to fuel arginine synthesis catalyzed by argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl), which would lead to abundant NO production.	Arginine	56-64	argininosuccinate lyase	Homo sapiens	151-154
9771895-1	1998	Human class I alcohol dehydrogenase was mutated at positions 57 and 115, exchanging for Asp and Arg respectively, in an attempt to introduce glutathione-dependent formaldehyde dehydrogenase characteristics.	Arginine	96-99	aldo-keto reductase family 1 member A1	Homo sapiens	14-35
22919255-8	2012	For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant association between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04).	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	4-9
9861481-12	1998	In codon 273, CGT for arginine was mutated to AGT for serine by a C to A transversion of the first letter.	Arginine	22-30	UDP glycosyltransferase 8	Homo sapiens	14-17
22582844-8	2012	Cathepsin H shows highest activities for cleaving N-terminal basic residues (Arg and Lys) among amino acid fluorogenic substrates.	Arginine	77-80	cathepsin H	Mus musculus	0-11
9760183-6	1998	Arginine residue mutations in Chs3p, and in Chs1p and Chs2p, resulted in a loss of both function in vivo and enzymatic activity.	Arginine	0-8	chitin synthase CHS3	Saccharomyces cerevisiae S288C	30-35
22709481-6	2012	Moreover, L-Arg-pretreated mice developed more splenic myeloid and plasmacytoid dendritic cells with up-regulated expression of MHC II, CD86 and TLR9.	Arginine	10-15	toll-like receptor 9	Mus musculus	145-149
9705322-12	1998	The phosphorylation site was identified as Ser* in the sequence Arg-Arg-Ser-Ser*-Trp-Arg in 14-3-3 beta.	Arginine	64-67	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Mus musculus	92-103
9705322-12	1998	The phosphorylation site was identified as Ser* in the sequence Arg-Arg-Ser-Ser*-Trp-Arg in 14-3-3 beta.	Arginine	68-71	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Mus musculus	92-103
9705322-12	1998	The phosphorylation site was identified as Ser* in the sequence Arg-Arg-Ser-Ser*-Trp-Arg in 14-3-3 beta.	Arginine	68-71	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	Mus musculus	92-103
22697391-3	2012	The Nuclear poly(A) binding protein 1 (PABPN1) is methylated by PRMT1 at 13 arginine residues located in RXR sequences in the protein"s C-terminal domain.	Arginine	76-84	protein arginine methyltransferase 1	Homo sapiens	64-69
9724167-8	1998	The catalase and Mn-SOD activities were significantly decreased throughout the study, while the GPx activity was significantly reduced at 6 and 12 hr, and the Cu,Zn-SOD activity was significantly lower at 12 hr after the Arg injection as compared with the controls.	Arginine	221-224	superoxide dismutase 2	Rattus norvegicus	17-23
22697391-3	2012	The Nuclear poly(A) binding protein 1 (PABPN1) is methylated by PRMT1 at 13 arginine residues located in RXR sequences in the protein"s C-terminal domain.	Arginine	76-84	retinoid X receptor alpha	Homo sapiens	105-108
22697391-8	2012	We suggest that the formation of a reverse turn facilitates the access of arginine side chains to the active sites of PRMT1, which are located in the central cavity of a doughnut-shaped PRMT1 homodimer.	Arginine	74-82	protein arginine methyltransferase 1	Homo sapiens	118-123
22697391-8	2012	We suggest that the formation of a reverse turn facilitates the access of arginine side chains to the active sites of PRMT1, which are located in the central cavity of a doughnut-shaped PRMT1 homodimer.	Arginine	74-82	protein arginine methyltransferase 1	Homo sapiens	186-191
22762146-5	2012	RESULTS: Exposure of BM cells to GM-CSF and IL-6 activated, within 24 h, L-Arg metabolizing enzymes which are responsible for the MDSCs immunosuppressive potential.	Arginine	73-78	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	33-39
9700994-6	1998	L-Arginine partially restored endothelium-dependent relaxation in parallel to increased urinary nitrate excretion and decreased urinary immunoreactive ET-1 excretion.	Arginine	0-10	endothelin-1	Oryctolagus cuniculus	151-155
9700994-8	1998	The contractile vascular response of aortic rings to exogenous ET-1 was increased in rabbits fed a high-cholesterol diet; this enhanced contractility to ET-1 was completely reversed by L-arginine.	Arginine	185-195	endothelin-1	Oryctolagus cuniculus	63-67
9700994-8	1998	The contractile vascular response of aortic rings to exogenous ET-1 was increased in rabbits fed a high-cholesterol diet; this enhanced contractility to ET-1 was completely reversed by L-arginine.	Arginine	185-195	endothelin-1	Oryctolagus cuniculus	153-157
9700994-9	1998	These data suggest that L-arginine restores endothelial function and normalizes the synthesis and vasoconstrictor response to ET-1 in hypercholesterolemia.	Arginine	24-34	endothelin-1	Oryctolagus cuniculus	126-130
22634310-2	2012	The present study was to investigate the possible protective and curative effects of L-arginine on carbon tetrachloride (CCl(4)) induced hepatotoxicity.	Arginine	85-95	chemokine (C-C motif) ligand 4	Mus musculus	121-127
9721983-8	1998	BK 2-3 formation is indicative of initial aminopeptidase-P cleavage of BK to yield Arg, and des-Arg1-BK.	Arginine	83-86	potassium voltage-gated channel subfamily A member 2	Rattus norvegicus	0-4
9671726-2	1998	Similar to ARF GAPs, the GAP domain of ARD1 contains a zinc finger motif and arginine residues that are critical for activity.	Arginine	77-85	tripartite motif containing 23	Homo sapiens	39-43
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	protein arginine methyltransferase 3	Rattus norvegicus	92-97
9642256-5	1998	A recombinant glutathione S-transferase (GST) fusion product of this new rat protein, named PRMT3, asymmetrically dimethylates arginine residues present both in the designed substrate GST-GAR and in substrate proteins present in hypomethylated extracts of a yeast rmt1 mutant that lacks type I arginine methyltransferase activity; PRMT3 is thus a functional type I protein arginine N-methyltransferase.	Arginine	127-135	protein arginine methyltransferase 3	Rattus norvegicus	331-336
9688574-5	1998	Addition of H4B increased the recombination rate constant (k(on)) for CO by more than two-fold in the presence of L-Arg or N6-(1-iminoethyl)-L-lysine, whereas it decreased the k(on) value by three-fold in the presence of L-thiocitrulline.	Arginine	114-119	H4 clustered histone 4	Homo sapiens	12-15
9688574-6	1998	Thus, the binding fashion of some of inhibitors, such as NI, may be different from that of L-Arg with respect to the H4B effect.	Arginine	91-96	H4 clustered histone 4	Homo sapiens	117-120
9675061-3	1998	We have now improved the expression of TP2 over fivefold by (1) optimizing the codons for lysine, arginine, proline, leucine, glycine, valine, threonine, alanine, and tyrosine and (2) by engineering the vector-encoded 5" UTR.	Arginine	98-106	transition protein 2	Rattus norvegicus	39-42
9642086-0	1998	An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.	Arginine	3-6	TARBP2 pseudogene 1	Homo sapiens	36-40
9611241-0	1998	Interaction between the N-terminal domain of human DNA topoisomerase I and the arginine-serine domain of its substrate determines phosphorylation of SF2/ASF splicing factor.	Arginine	79-87	serine and arginine rich splicing factor 1	Homo sapiens	149-152
9611241-3	1998	Using the prototypical SR protein SF2/ASF (SRp30a) as model substrate, we demonstrate that serine residues phosphorylated by topo I/kinase exclusively located within the most extended arginine-serine repeats of the SF2/ASF RS domain.	Arginine	184-192	serine and arginine rich splicing factor 1	Homo sapiens	34-41
9611241-3	1998	Using the prototypical SR protein SF2/ASF (SRp30a) as model substrate, we demonstrate that serine residues phosphorylated by topo I/kinase exclusively located within the most extended arginine-serine repeats of the SF2/ASF RS domain.	Arginine	184-192	serine and arginine rich splicing factor 1	Homo sapiens	43-49
9611241-3	1998	Using the prototypical SR protein SF2/ASF (SRp30a) as model substrate, we demonstrate that serine residues phosphorylated by topo I/kinase exclusively located within the most extended arginine-serine repeats of the SF2/ASF RS domain.	Arginine	184-192	serine and arginine rich splicing factor 1	Homo sapiens	215-222
9625728-7	1998	nNOS effectively reduced the quinones as well as PQ causing a marked decrease in the production of NO from l-arginine, while 1, 4-benzoquinone, 9,10-anthraquinone, mitomycin C, and lapachol, which show negligible inhibitory action on nNOS activity, were poor substrates for the enzyme on reduction.	Arginine	107-117	nitric oxide synthase 1	Rattus norvegicus	0-4
9625728-7	1998	nNOS effectively reduced the quinones as well as PQ causing a marked decrease in the production of NO from l-arginine, while 1, 4-benzoquinone, 9,10-anthraquinone, mitomycin C, and lapachol, which show negligible inhibitory action on nNOS activity, were poor substrates for the enzyme on reduction.	Arginine	107-117	nitric oxide synthase 1	Rattus norvegicus	234-238
9607842-6	1998	However, C3a and C3a(des)Arg affected endotoxin-induced IL-6 synthesis in a dose-dependent manner.	Arginine	25-28	complement C3	Homo sapiens	17-20
9607842-7	1998	In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels.	Arginine	36-39	complement C3	Homo sapiens	28-31
9607842-7	1998	In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels.	Arginine	36-39	complement C3	Homo sapiens	28-31
9607842-7	1998	In nonadherent PBMC, C3a or C3a(des)Arg suppressed, while in adherent PBMC, C3a or C3a(des)Arg enhanced IL-6 protein and mRNA levels.	Arginine	36-39	complement C3	Homo sapiens	28-31
9607842-8	1998	These results suggest that C3a and C3a(des)Arg may provide a control mechanism of acute-phase responses by enhancing IL-6 synthesis in adherent monocytes at local inflammatory sites and by inhibiting IL-6 synthesis in circulating monocytes.	Arginine	43-46	complement C3	Homo sapiens	35-38
9576954-0	1998	CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120.	Arginine	56-64	C-C motif chemokine receptor 5	Homo sapiens	0-4
9576954-4	1998	Site-directed mutagenesis carried out on three such V3 residues revealed that the Arg-298 of HIV-1 gp120 has an important role in CCR5 utilization.	Arginine	82-85	C-C motif chemokine receptor 5	Homo sapiens	130-134
9576954-6	1998	The inability of Arg-298 mutants to use CCR5 was not attributed to global alteration of gp120 conformation.	Arginine	17-20	C-C motif chemokine receptor 5	Homo sapiens	40-44
9576954-9	1998	Taken together, our data strongly suggests that the highly conserved Arg-298 residue identified in the V3 of HIV-1 has a significant role in CCR5 utilization, and may represent an unusually conserved target for future anti-viral designs.	Arginine	69-72	C-C motif chemokine receptor 5	Homo sapiens	141-145
9576960-4	1998	The competitive NO synthase inhibitor, L-nitroarginine methyl ester, prevents Ras activation elicited by NMDA and this effect is competitively reversed by the NO synthase substrate, L-arginine.	Arginine	182-192	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	78-81
9572852-8	1998	Accordingly, recombinant full-length nNOS containing BH4 and l-Arg is completely unable to form Fe(II)-nitrosoalkane complexes, even with CH3NO.	Arginine	61-66	nitric oxide synthase 1	Rattus norvegicus	37-41
9572852-10	1998	On the contrary, the distal heme pocket of iNOS and nNOS seems to be closed after binding of l-Arg and BH4, particularly in the Fe(II) state.	Arginine	93-98	nitric oxide synthase 1	Rattus norvegicus	52-56
9602069-6	1998	The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.	Arginine	83-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	150-153
9602069-6	1998	The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.	Arginine	83-88	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	162-166
9602069-6	1998	The blockade of KA-induced proENK and proDYN mRNA levels by the pre-treatment with L-ARG was well correlated with proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, JunD, JunB, and c-Jun, as well as AP-1 and ENKCRE-2 DNA binding activities.	Arginine	83-88	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	168-172
9603385-8	1998	This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC--&gt;CAC).	Arginine	146-154	transforming growth factor beta induced	Homo sapiens	88-97
9603385-8	1998	This was a substitution of G to A of the second nucleotide position of codon 124 in the betaig-h3 gene that led to a replacement of histidine for arginine (Arg124His, CGC--&gt;CAC).	Arginine	146-154	carbonic anhydrase 2	Homo sapiens	176-179
9551389-8	1998	In one of the three families there is a point mutation in exon 20 causing an arginine to glycine change, which is likely to alter structure and hence function of the factor H protein.	Arginine	77-85	complement factor H	Homo sapiens	166-174
9520431-6	1998	It was also found that the number of arginine residues increased substantially in a short period of evolutionary time after gene duplication, and these amino acid changes probably produced the novel anti-pathogen function of ECP.	Arginine	37-45	ribonuclease A family member 3	Homo sapiens	225-228
9501087-6	1998	The high affinity of endostatin for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues.	Arginine	114-122	collagen, type XVIII, alpha 1	Mus musculus	21-31
9521691-12	1998	Glycosaminoglycans had no significant inhibitory effect on apoB-MTP interactions, suggesting that the lysine and arginine residues crucial for apoB-MTP interactions are different from those that interact with the LDL receptor and heparin.	Arginine	113-121	microsomal triglyceride transfer protein	Homo sapiens	148-151
9521691-13	1998	The lysine and arginine residues in apoB18 may directly interact with negatively charged residues in the MTP molecule, or they may function to maintain the conformation of the recognition site.	Arginine	15-23	microsomal triglyceride transfer protein	Homo sapiens	105-108
9521659-3	1998	Kex2 exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1 (Lys-Arg or Arg-Arg cleavage sites).	Arginine	61-64	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9521659-3	1998	Kex2 exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1 (Lys-Arg or Arg-Arg cleavage sites).	Arginine	75-78	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9521659-3	1998	Kex2 exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1 (Lys-Arg or Arg-Arg cleavage sites).	Arginine	75-78	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9521659-3	1998	Kex2 exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1 (Lys-Arg or Arg-Arg cleavage sites).	Arginine	75-78	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9559895-5	1998	Six hours after intraplantar injection of carrageenan (1-3% w/v) hindpaw constitutive (i.e. calcium-dependent) nitric oxide synthase (cNOS) activity (determined ex vivo as the conversion of radiolabelled L-arginine to radiolabelled citrulline) was increased (e.g. 2% w/v; 0.64+/-0.08 pmol citrulline mg(-1) protein 15 min(-1) c.f.	Arginine	204-214	nitric oxide synthase 3	Rattus norvegicus	134-138
9498770-3	1998	Further examination of the three-dimensional structure in this region revealed conformational differences between human and murine beta2m that affect the ability of an aspartic acid residue at position 53 (D53) conserved in both beta 2ms to form an ionic bond with arginine residues at positions 35 and 48 of the heavy chain.	Arginine	265-273	hemoglobin, beta adult minor chain	Mus musculus	229-235
9495519-8	1998	This single base substitution changes the codon for arginine (CGA) to an opal stop codon (TGA), resulting in the truncation of the VDR at amino acid 30.	Arginine	52-60	vitamin D receptor	Homo sapiens	131-134
9521487-14	1998	The inhibitory effects of L-ARG on platelet aggregation in vitro were paralleled by increased cyclic GMP levels; L-ARG also inhibited platelet TXB2 formation in PRP anticoagulated with r-hirudin, but not citrate.	Arginine	26-31	5'-nucleotidase, cytosolic II	Homo sapiens	101-104
22634310-4	2012	L-arginine treatment was given for 6 days prior or post to CCl(4) injection.	Arginine	0-10	chemokine (C-C motif) ligand 4	Mus musculus	59-65
22634310-9	2012	These results suggest that L-arginine administration has hepatoprotective and hepatocurative effects against CCl(4) induced hepatotoxicity in mice.	Arginine	27-37	chemokine (C-C motif) ligand 4	Mus musculus	109-115
22713831-12	2012	CONCLUSION: This study provides information to support the effectiveness of L-Arg supplement treatment in CTRT-D patients; in fact the syndromic pattern of cognitive and linguistic deficit presented by CRTR-D patients was partially altered by L-Arg supplementation especially at a qualitative clinical level.	Arginine	76-81	solute carrier family 6 member 8	Homo sapiens	202-206
9510129-5	1998	Formation of TPO compound I may also depend on Arg 396, based on analogy with the catalytic mechanism previously proposed for the more widely studied plant and fungal peroxidases.	Arginine	47-50	thyroid peroxidase	Homo sapiens	13-16
22713831-12	2012	CONCLUSION: This study provides information to support the effectiveness of L-Arg supplement treatment in CTRT-D patients; in fact the syndromic pattern of cognitive and linguistic deficit presented by CRTR-D patients was partially altered by L-Arg supplementation especially at a qualitative clinical level.	Arginine	243-248	solute carrier family 6 member 8	Homo sapiens	202-206
22495673-3	2012	The aspartic acid changes at position 89 to either Ala, Leu, or Arg generated mutant receptors with varying expression profiles and a complete inability to bind somatostatin-14 (SST).	Arginine	64-67	somatostatin	Homo sapiens	161-176
9507156-5	1998	After 7 days in culture, application of glutamate (1 mM) or L-arginine (0.3 mM) to the cultured medium increased NO concentration, and decreased the number of anti-microtubule-associated protein 2 positive neurons.	Arginine	60-70	microtubule associated protein 2	Homo sapiens	164-196
22495673-3	2012	The aspartic acid changes at position 89 to either Ala, Leu, or Arg generated mutant receptors with varying expression profiles and a complete inability to bind somatostatin-14 (SST).	Arginine	64-67	somatostatin	Homo sapiens	178-181
22495673-4	2012	Mutations to Asp 139 and Arg 140 also led to varying expression profiles with some mutants maintaining their affinity for SST.	Arginine	25-28	somatostatin	Homo sapiens	122-125
22302399-5	2012	Patients having XRCC1 399 Arg/Gln (OR:1.98; 95% CI: 1.21-3.25, P = 0.007) or XRCC1-399 Gln/Gln (OR: 3.95; 95% CI: 1.45-10.76, P = 0.005) genotype had a significantly higher risk of ESRD than those with XRCC1 399 Arg/Arg genotype.	Arginine	26-29	X-ray repair cross complementing 1	Homo sapiens	16-21
22826949-2	2012	cDNA of pig c-Myc gene was amplified by RT-PCR with specific primers of 9 arginine (R9) from the primordial genital ridges and inserted into prokaryotic expression vector pET-28a-EGFP.	Arginine	74-82	phosphatidylinositol glycan anchor biosynthesis class C	Sus scrofa	8-13
22826949-2	2012	cDNA of pig c-Myc gene was amplified by RT-PCR with specific primers of 9 arginine (R9) from the primordial genital ridges and inserted into prokaryotic expression vector pET-28a-EGFP.	Arginine	74-82	MYC proto-oncogene, bHLH transcription factor	Sus scrofa	14-17
22937649-8	2012	The increase of arginine, ornithine, and methionine contents promoted the activities of polyamines synthesis enzymes, which led to the significant increase of polyamines contents and the significant decrease of DAO and PAO activities.	Arginine	16-24	polyamine oxidase	Homo sapiens	219-222
22651848-8	2012	RESULTS: At 72 hours after the hepatectomy, the restituted liver mass, the PCNA labeling index and the DNA quantity were all significantly higher in the L-arginine and L-glutamine groups than in the control.	Arginine	153-163	proliferating cell nuclear antigen	Rattus norvegicus	75-79
22457348-9	2012	Two amino acids (lysine 715 and arginine 716) of the TRPC4 C terminus were identified by structural modeling as mediating the interaction with Galpha(i2).	Arginine	32-40	transient receptor potential cation channel subfamily C member 4	Homo sapiens	53-58
22066718-4	2012	A novel heterozygous mutation in exon 2 of GCMB was identified in both affected individuals that changes cysteine at position 106 of the putative DNA-binding domain of GCMB to arginine (C106R).	Arginine	176-184	glial cells missing transcription factor 2	Homo sapiens	43-47
22066718-4	2012	A novel heterozygous mutation in exon 2 of GCMB was identified in both affected individuals that changes cysteine at position 106 of the putative DNA-binding domain of GCMB to arginine (C106R).	Arginine	176-184	glial cells missing transcription factor 2	Homo sapiens	168-172
22774401-1	2012	BACKGROUND: The aim of our study was to investigate the interaction of tryptophan-to-arginine (Trp64Arg) missense mutation in the beta3 adrenoreceptor (Beta3AR) with polymorphism in the UCP3 promotor (-55C-&gt;T) on insulin resistance in obese patients.	Arginine	85-93	uncoupling protein 3	Homo sapiens	186-190
23226579-4	2012	Thus, c-Abl/Arg may serve as molecular switches that suppress proliferation and invasion in response to some stimuli (e.g., ephrins) or when inactive/regulated, or as promote invasion and proliferation in response to other signals (e.g., activated growth factor receptors, loss of inhibitor expression), which induce sustained activation.	Arginine	12-15	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	6-11
23226579-7	2012	Targeted trials are critical for determining whether c-Abl/Arg inhibitors can be effective treatment options for patients whose tumors are driven by c-Abl/Arg.	Arginine	59-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	149-154
23226579-7	2012	Targeted trials are critical for determining whether c-Abl/Arg inhibitors can be effective treatment options for patients whose tumors are driven by c-Abl/Arg.	Arginine	155-158	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	53-58
22391327-2	2012	Arginase-2 competes with eNOS for l-arginine, and its activity has been related with vascular dysfunction.	Arginine	34-44	arginase 2	Homo sapiens	0-10
22455451-3	2012	It is well-documented that the RGD (Arg-Gly-Asp) motif exhibits high binding affinity to integrin alpha(v)beta(3), which is abundantly expressed in cancer cells and specifically associated with angiogenesis on tumors.	Arginine	36-39	integrin subunit alpha V	Homo sapiens	89-113
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	151-159	argininosuccinate lyase	Homo sapiens	76-99
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	151-159	argininosuccinate lyase	Homo sapiens	101-104
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	181-189	argininosuccinate lyase	Homo sapiens	76-99
21567240-2	2012	Arginine production is controlled by argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) which metabolize citrulline and aspartate to arginine and fumarate whereas arginine consumption is dependent on arginine:glycine amidinotransferase (GAT), which mediates creatine and ornithine synthesis.	Arginine	181-189	argininosuccinate lyase	Homo sapiens	101-104
22262306-8	2012	The primary vasopressin receptor was vasopressin receptor 1a (V1aR), as suggested by the excitation by V1aR agonist [Arg(8)]vasotocin, the selective V1aR agonist [Phe(2)]OVT and by the presence of V1aR mRNA in MCH cells, but not in other nearby GABA cells, as detected with single-cell RT-PCR.	Arginine	117-120	arginine vasopressin receptor 1A	Mus musculus	62-66
22262306-8	2012	The primary vasopressin receptor was vasopressin receptor 1a (V1aR), as suggested by the excitation by V1aR agonist [Arg(8)]vasotocin, the selective V1aR agonist [Phe(2)]OVT and by the presence of V1aR mRNA in MCH cells, but not in other nearby GABA cells, as detected with single-cell RT-PCR.	Arginine	117-120	arginine vasopressin receptor 1A	Mus musculus	103-107
22262306-8	2012	The primary vasopressin receptor was vasopressin receptor 1a (V1aR), as suggested by the excitation by V1aR agonist [Arg(8)]vasotocin, the selective V1aR agonist [Phe(2)]OVT and by the presence of V1aR mRNA in MCH cells, but not in other nearby GABA cells, as detected with single-cell RT-PCR.	Arginine	117-120	arginine vasopressin receptor 1A	Mus musculus	103-107
22262306-8	2012	The primary vasopressin receptor was vasopressin receptor 1a (V1aR), as suggested by the excitation by V1aR agonist [Arg(8)]vasotocin, the selective V1aR agonist [Phe(2)]OVT and by the presence of V1aR mRNA in MCH cells, but not in other nearby GABA cells, as detected with single-cell RT-PCR.	Arginine	117-120	arginine vasopressin receptor 1A	Mus musculus	103-107
22330678-10	2012	We further demonstrate that the interaction of cathepsin Z with arginine-glycine-aspartic acid-binding integrins, specifically alphavbeta5, mediates the changes seen in adhesion of PDAC cells.	Arginine	64-72	cathepsin Z	Homo sapiens	47-58
22084859-12	2012	We concluded that XRCC1 399 Arg-related genotype and allele are correlated with higher susceptibility to endometriosis, which suggested its association with endometriosis pathogenesis.	Arginine	28-31	X-ray repair cross complementing 1	Homo sapiens	18-23
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Arginine	51-54	Rho family GTPase 3	Homo sapiens	9-13
22357615-6	2012	Rnd1 and Rnd3, but not Rnd2, have a KERRA (Lys-Glu-Arg-Arg-Ala) sequence of amino acids in their N-terminus, which functions as the lipid raft-targeting determinant.	Arginine	55-58	Rho family GTPase 3	Homo sapiens	9-13
22352868-1	2012	A structure-activity relationship study on a highly potent CXC chemokine receptor type 4 (CXCR4) antagonist, FC131 [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)], was carried out using a series of alkene isosteres of the d-Tyr(1)-l/d-Arg(2) dipeptide to investigate the binding mode of FC131 and its derivatives with CXCR4.	Arginine	131-135	C-X-C motif chemokine receptor 4	Homo sapiens	59-88
22352868-1	2012	A structure-activity relationship study on a highly potent CXC chemokine receptor type 4 (CXCR4) antagonist, FC131 [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)], was carried out using a series of alkene isosteres of the d-Tyr(1)-l/d-Arg(2) dipeptide to investigate the binding mode of FC131 and its derivatives with CXCR4.	Arginine	131-135	C-X-C motif chemokine receptor 4	Homo sapiens	90-95
22457887-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	integrin subunit alpha V	Homo sapiens	12-32
22457887-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	vitronectin	Homo sapiens	81-92
22221800-3	2012	In order to elucidate the structure-function-stability relationship of this enzyme, two residues in its active site were replaced with the residues that occur in the human l-arginine:glycine amidinotransferase (h-AGAT) at the corresponding positions (F245N and S247M), and a double variant carrying both substitutions was also created.	Arginine	172-182	glycine amidinotransferase	Homo sapiens	213-217
22325912-6	2012	We found significant increase both in ADH1B (Arg48His) polymorphism Arg allele and Arg/Arg genotype frequency in patients.	Arginine	45-48	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	38-43
22325912-6	2012	We found significant increase both in ADH1B (Arg48His) polymorphism Arg allele and Arg/Arg genotype frequency in patients.	Arginine	68-71	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	38-43
22325912-6	2012	We found significant increase both in ADH1B (Arg48His) polymorphism Arg allele and Arg/Arg genotype frequency in patients.	Arginine	68-71	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	38-43
22239978-11	2012	In addition, both Rb1 and Rg1 induce nitric oxide (NO) generation through increasing the phosphorylation of eNOS, activating Na+-independent l-arginine transport, and stimulating cationic amino acid transport (CAT)-1 mRNA expression in cultured endothelial cells.	Arginine	141-151	RB transcriptional corepressor 1	Mus musculus	18-21
22184126-11	2012	In contrast, replacing Arg(82), but not Arg(93), substantially reduces the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays a general role in substrate recognition, whereas Arg(93) specifically functions in NCAM recognition.	Arginine	23-26	neuropilin 2	Homo sapiens	116-128
22244851-0	2012	Subcellular distribution of the human putative nucleolar GTPase GNL1 is regulated by a novel arginine/lysine-rich domain and a GTP binding domain in a cell cycle-dependent manner.	Arginine	93-101	G protein nucleolar 1 (putative)	Homo sapiens	64-68
22244851-3	2012	To understand the nuclear transport mechanism of GNL1, we have identified a novel arginine/lysine-rich nucleolar localization signal in the NH(2)-terminus that is shown to translocate GNL1 and a heterologous protein to the nucleus/nucleolus in a pathway that is independent of importin-alpha and importin-beta.	Arginine	82-90	G protein nucleolar 1 (putative)	Homo sapiens	49-53
22244851-3	2012	To understand the nuclear transport mechanism of GNL1, we have identified a novel arginine/lysine-rich nucleolar localization signal in the NH(2)-terminus that is shown to translocate GNL1 and a heterologous protein to the nucleus/nucleolus in a pathway that is independent of importin-alpha and importin-beta.	Arginine	82-90	G protein nucleolar 1 (putative)	Homo sapiens	184-188
22297987-0	2012	Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.	Arginine	81-84	cortactin	Homo sapiens	71-80
9618055-1	1998	To determine the gestational maturation of fetal insulin response to glucose and arginine and the effects of sustained hyperglycemia on these processes, we measured insulin secretion in different groups of fetal sheep at 75, 100, 122, and 137 days of gestation (50, 67, 81, and 91% of term gestation, respectively).	Arginine	81-89	LOC105613195	Ovis aries	49-56
9618055-6	1998	Thus, glucose and arginine stimulate insulin secretion at midgestation at 20% of the rate near term, and there is a consistently positive developmental pattern of insulin secretion to these secretagogues over the second half of gestation.	Arginine	18-26	LOC105613195	Ovis aries	37-44
22664242-2	2012	Of these, the radiolabeled Arg-Gly- Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3.	Arginine	27-30	integrin subunit alpha V	Homo sapiens	120-142
11253785-3	1998	Endothelial nitric oxide synthase (NOS) activity was inhibited by intraphrenic infusion of L-arginine analogues such as N(G)-nitro-L-arginine, N(G)-nitro-L-arginine methyl ester and argininosuccinic acid.	Arginine	91-101	nitric oxide synthase 3	Canis lupus familiaris	12-33
9826914-9	1998	Arginine could also be substituted by other amino acids without loss of coupling to Gs demonstrating an unexpected lack of selectivity in the human beta 2-adrenergic receptor protein, and ruling out a requirement for the side chain of arginine in signalling to G proteins.	Arginine	0-8	adrenoceptor beta 2	Homo sapiens	148-174
10067282-3	1998	The results showed that the arginine residues at the positions of 459 and 463 of G6PD gene play an important role in maintaining activity of the enzyme.	Arginine	28-36	glucose-6-phosphate dehydrogenase	Homo sapiens	81-85
9395478-2	1997	Cells adhere to the extracellular matrix proteins fibronectin and tenascin in part by the interaction of certain integrins with the Arg-Gly-Asp (RGD) sequence, displayed on specific FNIII repeats.	Arginine	132-135	tenascin C	Homo sapiens	66-74
9393691-7	1997	The argR gene, which is located upstream of the aruCFGDB operon, is a member of another (aot) operon coding for arginine transport genes.	Arginine	112-120	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	4-8
9359845-8	1997	These results show that the N-terminal stretch of four consecutive arginine residues, Arg2-Arg3-Arg4-Arg5, has a decisive role in the interaction of hLF with heparin, lipid A, hLZ and DNA.	Arginine	67-75	arginase 2	Homo sapiens	86-90
9389442-5	1997	A single amino acid difference, either arginine (R) or histidine (H) at amino acid position 131, underlies differential interaction with mIgG1.	Arginine	39-47	LOC105243590	Mus musculus	137-142
9349532-3	1997	Previous studies have indicated that alpha-thrombin and SFLLRN (synthetic hexapeptide sequence of serine, phenylalanine, leucine, leucine, arginine, asparagine; the human thrombin receptor "tethered ligand") induce neurite retraction and neurotoxicity.	Arginine	139-147	coagulation factor II (thrombin) receptor	Rattus norvegicus	171-188
9342325-9	1997	A prominent exception represents thrombin"s Arg-77A side chain, which extends into a hydrophobic triabin pocket forming partially buried salt bridges with Glu-128 and Asp-135 of the inhibitor.	Arginine	44-47	coagulation factor II, thrombin	Bos taurus	33-41
9377551-5	1997	NKX3.1 was found to have a polymorphism at nucleotide 154 in codon 52 that resulted in a CGC--&gt;TGC sequence change and an Arg--&gt;Cys amino acid alteration (R52C).	Arginine	125-128	NK3 homeobox 1	Homo sapiens	0-6
9350338-6	1997	60% of inhibition was observed with 10 microM of L-arginine or polyamines in PRP of normal rats, and 50% with PRP of diabetic rats when thrombin was used as an agonist.	Arginine	49-59	proline rich protein 2-like 1	Rattus norvegicus	77-80
9329083-8	1997	A major difference is the participation of Arg 312 and Asp 313 in lining the inhibitor-binding site in aldehyde reductase but not in aldose reductase.	Arginine	43-46	aldo-keto reductase family 1 member A1	Homo sapiens	103-121
9305916-6	1997	A conserved arginine in FEN-1 (Arg339) and XPG (Arg992) was found to be crucial for PCNA binding activity.	Arginine	12-20	ERCC excision repair 5, endonuclease	Homo sapiens	43-46
9261398-3	1997	In particular, mutation of a glutamic acid residue located at CD4 residue 405 or of arginine and methionine residues located, respectively, at residue 406 and 407 results in a mutant CD4 protein that is efficiently downregulated by HIV-1 Nef but refractory to downregulation by SIV Nef.	Arginine	84-92	Nef	Human immunodeficiency virus 1	238-241
9261398-3	1997	In particular, mutation of a glutamic acid residue located at CD4 residue 405 or of arginine and methionine residues located, respectively, at residue 406 and 407 results in a mutant CD4 protein that is efficiently downregulated by HIV-1 Nef but refractory to downregulation by SIV Nef.	Arginine	84-92	Nef	Human immunodeficiency virus 1	282-285
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	24-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	24-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-118
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	86-89	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	86-89	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-118
23056045-0	2012	Arginine 16 Glycine Polymorphism in beta2-Adrenergic Receptor Gene is Associated with Obesity, Hyperlipidemia, Hyperleptinemia, and Insulin Resistance in Saudis.	Arginine	0-8	adrenoceptor beta 2	Homo sapiens	36-61
21765176-3	2012	Here, we report that CRY1(G380R), which carries a Gly-to-Arg substitution of the highly conserved G380 in the photolyase-related (PHR) domain of Arabidopsis CRY1, shows constitutive CRY1 photoreceptor activity in Arabidopsis.	Arginine	57-60	cryptochrome 1	Arabidopsis thaliana	21-25
9310409-1	1997	It has previously been suggested that increases of L-arginine uptake into brain following portacaval shunting may result in increased activities of constitutive neuronal nitric oxide synthase (nNOS).	Arginine	51-61	nitric oxide synthase 1	Rattus norvegicus	161-191
9310409-1	1997	It has previously been suggested that increases of L-arginine uptake into brain following portacaval shunting may result in increased activities of constitutive neuronal nitric oxide synthase (nNOS).	Arginine	51-61	nitric oxide synthase 1	Rattus norvegicus	193-197
9277430-7	1997	The contractile action of neurotensin, observed in the absence of atropine and nifedipine, was potentiated by L-NAME (10(-4) M); L-arginine (5 x 10(-3) M) prevented the L-NAME effect.	Arginine	129-139	neurotensin	Rattus norvegicus	26-37
9220985-6	1997	These results illustrate that these Arg residues in anion binding exosite 2 contribute very differently to the diverse reactions dependent on that domain in thrombin.	Arginine	36-39	prothrombin	Oryctolagus cuniculus	157-165
9218440-6	1997	Our previous studies have identified a mutation at position 332 within Drosophila TBP that changes a highly conserved arginine residue to a histidine residue, which renders it specifically defective in its ability to support RNA polymerase III transcription in S-2 cells (Trivedi, A., Vilalta, A., Gopalan, S., and Johnson, D. L. (1996) Mol.	Arginine	118-126	df	Drosophila melanogaster	189-198
9224737-5	1997	The enzyme purified in the presence of both L-Arg and H4B is highly active, with a Vmax of approximately 800 nmol NO min(-1) mg(-1) and a Km for L-Arg of 22 microM.	Arginine	145-150	H4 clustered histone 4	Homo sapiens	54-57
9215684-7	1997	All affected individuals also carried missense mutations in exon 73 of COL7A1 which lead to different glycine-to-arginine substitutions in the triple-helical domain of collagen VII.	Arginine	113-121	collagen type VII alpha 1 chain	Homo sapiens	71-77
9164941-6	1997	Mutation at leucine 82 and arginine 83, the residues common to Bw4 motifs, shows they contribute to NKB1 interaction but are not essential.	Arginine	27-35	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	100-104
9192308-9	1997	The dopamine precursor L-beta-3,4-dihydroxyphenylalanine (L-DOPA) inhibited cleavage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with COOH-terminal glycine, i.e. [35S]G34-Gly, at a pair of lysine residues, but did not influence cleavage of progastrin at pairs of arginine residues.	Arginine	307-315	gastrin	Rattus norvegicus	133-140
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Arginine	198-201	carboxypeptidase N subunit 1	Homo sapiens	17-42
9162090-1	1997	The precursor of plasma carboxypeptidase B (pCPB) also known as thrombin-activable fibrinolysis inhibitor can be converted by thrombin to an active enzyme capable of eliminating C-terminal Lys- and Arg-residues from proteins.	Arginine	198-201	carboxypeptidase N subunit 1	Homo sapiens	44-48
9171884-6	1997	Analogue Ac-Nle-c[Asp-His-Phe7-Arg-Trp-Ala-Lys]-NH2 resulted in micromolar binding affinity (or greater) at the hMC3R and hMC5R, demonstrating the importance of D-Phe7 for ligand binding potency at these receptors.	Arginine	31-34	melanocortin 5 receptor	Homo sapiens	122-127
9184235-8	1997	The preferred orientation of heterodimer binding is determined both by contacts between a conserved arginine in the basic region of Fos and the central asymmetric guanine as well as the structure of sequences flanking the AP-1 site.	Arginine	100-108	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-135
9180275-1	1997	The Candida albicans CAN1 gene, encoding a high-affinity permease for arginine, lysine and histidine, was tagged at its C-terminus with a c-myc epitope and introduced into strains of Saccharomyces cerevisiae lacking basic amino acid permeases.	Arginine	70-78	arginine permease CAN1	Saccharomyces cerevisiae S288C	21-25
9184911-10	1997	Three IgM antibodies had hydrophilic arginine residues in their CDR3 heavy chain region.	Arginine	37-45	immunoglobulin heavy constant mu	Mus musculus	6-9
21765176-3	2012	Here, we report that CRY1(G380R), which carries a Gly-to-Arg substitution of the highly conserved G380 in the photolyase-related (PHR) domain of Arabidopsis CRY1, shows constitutive CRY1 photoreceptor activity in Arabidopsis.	Arginine	57-60	cryptochrome 1	Arabidopsis thaliana	157-161
9175051-4	1997	The ability to activate complement, measured as changes in the plasma concentrations of C3a des Arg and the terminal complement complex, and to produce leukopenia was greater for the dialyser containing Cuprophan membrane than for the other three.	Arginine	96-99	complement C3	Homo sapiens	88-91
21765176-3	2012	Here, we report that CRY1(G380R), which carries a Gly-to-Arg substitution of the highly conserved G380 in the photolyase-related (PHR) domain of Arabidopsis CRY1, shows constitutive CRY1 photoreceptor activity in Arabidopsis.	Arginine	57-60	cryptochrome 1	Arabidopsis thaliana	157-161
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Arginine	26-35	RB transcriptional corepressor like 2	Mus musculus	73-76
23029429-7	2012	Replacement of lysines by arginines strongly inhibits phosphorylation of Rb2/p130 by CDK4; the inhibitory effect of replacement by glutamines is less pronounced.	Arginine	26-35	RB transcriptional corepressor like 2	Mus musculus	77-81
22844517-1	2012	Adenosine causes vasodilation of human placenta vasculature by increasing the transport of arginine via cationic amino acid transporters 1 (hCAT-1).	Arginine	91-99	solute carrier family 7 member 1	Homo sapiens	140-146
22723830-0	2012	A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin.	Arginine	37-45	coactivator associated arginine methyltransferase 1	Homo sapiens	11-16
22723830-8	2012	Taking together, our study provides evidence for a role of CARM1-mediated arginine methylation in regulation of histone acetylation and transcription: facilitating transcription by discharging corepressors from chromatin.	Arginine	74-82	coactivator associated arginine methyltransferase 1	Homo sapiens	59-64
22655084-3	2012	The Arg-Gly-Asp (RGD) motif-containing peptides are specifically bound to integrin-alphavbeta3, and to inhibit neovasculature underlying competition to normal extracellular matrix proteins.	Arginine	4-7	integrin subunit alpha V	Homo sapiens	74-94
22052907-5	2011	We also report that TTHA0420 has not only the flavin reductase motif GDH but also a specific motif YGG in C terminus as well as Phe-41 and Arg-11, which are conserved in its subclass.	Arginine	139-142	flavin reductase family protein	Thermus thermophilus HB8	20-28
21810021-4	2011	RESULTS: We have found that the KIF6 719 Arg carriers were not at a significantly higher risk for CAD/non-fatal MI in this case-control study of an Indo-European population from Western India (Unadjusted odds ratio [OR] 0.767 95% confidence interval [CI] 0.573-1.027 for 719Arg carriers).	Arginine	41-44	kinesin family member 6	Homo sapiens	32-36
9125501-5	1997	An energy decomposition analysis indicates that specific MDH residues (Arg-81, Arg-87, Asn-119, Asp-150, and Arg-153) in the vicinity of the substrate make significant energetic contributions to the stabilization of proton transfer and destabilization of hydride transfer.	Arginine	71-74	malic enzyme 1	Homo sapiens	57-60
9125501-5	1997	An energy decomposition analysis indicates that specific MDH residues (Arg-81, Arg-87, Asn-119, Asp-150, and Arg-153) in the vicinity of the substrate make significant energetic contributions to the stabilization of proton transfer and destabilization of hydride transfer.	Arginine	79-82	malic enzyme 1	Homo sapiens	57-60
9125501-5	1997	An energy decomposition analysis indicates that specific MDH residues (Arg-81, Arg-87, Asn-119, Asp-150, and Arg-153) in the vicinity of the substrate make significant energetic contributions to the stabilization of proton transfer and destabilization of hydride transfer.	Arginine	79-82	malic enzyme 1	Homo sapiens	57-60
9155014-3	1997	The residues in G(M[63-75]) that interact with PP1c are those in the Arg/Lys-Val/Ile-Xaa-Phe motif that is present in almost every other identified mammalian PP1-binding subunit.	Arginine	69-72	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	47-51
9201397-8	1997	The hemagglutinin of Q1/95 and P11/ 94B parent stock and derivative AIVs had an identical proteolytic cleavage site of.... Pro-Gln-Arg-Lys-Arg-Lys-Thr-Arg-Gly, consistent with AIVs of high pathogenicity.	Arginine	131-134	S100 calcium binding protein A10	Gallus gallus	31-34
9201397-8	1997	The hemagglutinin of Q1/95 and P11/ 94B parent stock and derivative AIVs had an identical proteolytic cleavage site of.... Pro-Gln-Arg-Lys-Arg-Lys-Thr-Arg-Gly, consistent with AIVs of high pathogenicity.	Arginine	139-142	S100 calcium binding protein A10	Gallus gallus	31-34
9201397-8	1997	The hemagglutinin of Q1/95 and P11/ 94B parent stock and derivative AIVs had an identical proteolytic cleavage site of.... Pro-Gln-Arg-Lys-Arg-Lys-Thr-Arg-Gly, consistent with AIVs of high pathogenicity.	Arginine	139-142	S100 calcium binding protein A10	Gallus gallus	31-34
9103529-4	1997	A23187, bradykinin or substance P increased NO synthesis from L-arginine by EC in the presence or absence of L-glutamine.	Arginine	62-72	kininogen 1	Bos taurus	8-18
9085842-5	1997	Three proteins in the tri-snRNP complex with approximate molecular weights of 27, 60, and 100 kDa were phosphorylated by purified snRNP-associated protein kinase, which has been shown previously to phosphorylate the serine/ arginine-rich domains of U1-70K and SF2/ASF (Woppmann A et al., 1993, Nucleic Acids Res 21:2815-2822).	Arginine	224-232	serine and arginine rich splicing factor 1	Homo sapiens	260-267
9105424-2	1997	In addition, the authors compared the effect of contrast media on inulin-mediated generation of the anaphylatoxin derivative C3a des Arg in sera from urticarial reactors and their non-reacting controls.	Arginine	133-136	complement C3	Homo sapiens	125-128
9105424-5	1997	Instead, inulin-induced generation of C3a des Arg was inhibited by all the four contrast media.	Arginine	46-49	complement C3	Homo sapiens	38-41
9065469-8	1997	The neutralization of prothrombinase activity coincided with cleavages at Arg-506 and subsequent cleavage at Arg-306 of the factor Va heavy chain by activated protein C. Thus, the protein C pathway combined with TFPI creates a minimal inhibitory potential required to shut down TF-initiated thrombin generation.	Arginine	74-77	coagulation factor X	Homo sapiens	22-36
9065469-8	1997	The neutralization of prothrombinase activity coincided with cleavages at Arg-506 and subsequent cleavage at Arg-306 of the factor Va heavy chain by activated protein C. Thus, the protein C pathway combined with TFPI creates a minimal inhibitory potential required to shut down TF-initiated thrombin generation.	Arginine	109-112	coagulation factor X	Homo sapiens	22-36
9050841-6	1997	In contrast, the intrasubunit salt bridge between Glu-409 and Arg-501 becomes significantly weaker during the ATP-induced allosteric transitions of GroEL.	Arginine	62-65	heat shock protein family D (Hsp60) member 1	Homo sapiens	148-153
9042931-9	1997	Our results indicate that the combination DQA1#52 (Arg predisposing) DQB1#57 (Asp protective), which has been proposed as an important IDDM agent, does not include all the predisposing elements.	Arginine	51-54	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	69-73
21969604-7	2011	Mutation of the catalytic arginine of the GAP domain of RhoGAP22 potentiated growth factor-stimulated Rac1 GTP loading.	Arginine	26-34	Rac family small GTPase 1	Homo sapiens	102-106
22152690-13	2011	Patients with XRCC3 241 Thr/Met, 399 Arg/Arg, and at least one XRCC1 194 Trp allele simultaneously showed an improved objective response rate.	Arginine	41-44	X-ray repair cross complementing 3	Homo sapiens	14-19
9023367-6	1997	Both the in vitro binding of SF2/ASF to the Rev/RRE complex and the in vivo inhibition of Rev action by SF2/ASF are abrogated by mutation of the N-terminal RNA recognition motif but are not affected by mutation of the C-terminal arginine-serine-rich domain.	Arginine	229-237	serine and arginine rich splicing factor 1	Homo sapiens	29-32
9023367-6	1997	Both the in vitro binding of SF2/ASF to the Rev/RRE complex and the in vivo inhibition of Rev action by SF2/ASF are abrogated by mutation of the N-terminal RNA recognition motif but are not affected by mutation of the C-terminal arginine-serine-rich domain.	Arginine	229-237	serine and arginine rich splicing factor 1	Homo sapiens	33-36
22091477-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
9023367-6	1997	Both the in vitro binding of SF2/ASF to the Rev/RRE complex and the in vivo inhibition of Rev action by SF2/ASF are abrogated by mutation of the N-terminal RNA recognition motif but are not affected by mutation of the C-terminal arginine-serine-rich domain.	Arginine	229-237	serine and arginine rich splicing factor 1	Homo sapiens	104-107
9023367-6	1997	Both the in vitro binding of SF2/ASF to the Rev/RRE complex and the in vivo inhibition of Rev action by SF2/ASF are abrogated by mutation of the N-terminal RNA recognition motif but are not affected by mutation of the C-terminal arginine-serine-rich domain.	Arginine	229-237	serine and arginine rich splicing factor 1	Homo sapiens	108-111
9052446-5	1997	RESULTS: Tumours from patients receiving L-arginine contained increased numbers of specific cell subsets within the tumour which expressed CD16 (P = 0.004) and CD56 (P = 0.001) surface markers, when compared with tumours from control patients.	Arginine	41-51	Fc gamma receptor IIIa	Homo sapiens	139-143
9179619-6	1997	Our findings suggest that tPA reduces neutrophil O2.- generation by a mechanism that is not related to L-arginine, is not dependent on tPA proteolytic activity, and is not a function of direct scavenging.	Arginine	103-113	chromosome 20 open reading frame 181	Homo sapiens	26-29
22713184-15	2011	The existence of genetic polymorphisms of ADRB2 gene, already described in the literature, show an increasing in bronchodilation response of Arg/Arg homozygotes when beta-adrenergic therapeutic is replaced for the anticholinergic one.	Arginine	141-144	adrenoceptor beta 2	Homo sapiens	42-47
9381974-11	1997	Alanine scanning mutagenesis of residues in the immediate vicinity of the phosphorylation site (serine 293) indicates that only arginine 288 is required for recognition of serine 293 as a phosphorylation site by the branched-chain alpha-ketoacid dehydrogenase kinase.	Arginine	128-136	branched chain ketoacid dehydrogenase kinase	Rattus norvegicus	216-266
22713184-15	2011	The existence of genetic polymorphisms of ADRB2 gene, already described in the literature, show an increasing in bronchodilation response of Arg/Arg homozygotes when beta-adrenergic therapeutic is replaced for the anticholinergic one.	Arginine	145-148	adrenoceptor beta 2	Homo sapiens	42-47
22001918-4	2011	The influence of arginine monomethylation in histone H3 on the acetylation of lysine residues by histone acetyltransferase hGCN5 was investigated, and the results demonstrated that K9 acetylation was suppressed by the methylation of R8 and R17 but not by R26 methylation.	Arginine	17-25	lysine acetyltransferase 2A	Homo sapiens	123-128
8989245-6	1997	GHBP was inversely proportional to arginine-stimulated GH release (r = -0.346; P = 0.027) and negatively associated with several measures of spontaneous GH release as estimated by deconvolution analysis (GH mass, GH production rate, and mean GH; r = -0.371; P = 0.017, r = -0.393; P = 0.011, and r = -0.343; P = 0.028, respectively)).	Arginine	35-43	growth hormone receptor	Homo sapiens	0-4
21947296-5	2011	Acetylcholine-stimulated NO levels (electrode measurements) and N-nitro-l-arginine methyl ester-sensitive l-arginine conversion (radioisotope measurements) were reduced in arteries from NBCn1 knockout mice, whereas relaxation to NO-donor S-nitroso-N-acetylpenicillamine, acetylcholine-induced endothelial Ca2+ responses (fluorescence microscopy), and total and Ser-1177 phosphorylated endothelial NO-synthase expression (Western blot analyses) were unaffected.	Arginine	72-82	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Mus musculus	186-191
9194695-7	1997	In the absence of added tetrahydrobiopterin, TRIM competed with L-arginine for the substrate binding site on the nNOS enzyme with a Ki value of 47.3 microM.	Arginine	64-74	nitric oxide synthase 1	Rattus norvegicus	113-117
9194695-8	1997	The present experiments suggest that TRIM interferes with the binding of both L-arginine and tetrahydrobiopterin to their respective sites on the nNOS enzyme.	Arginine	78-88	nitric oxide synthase 1	Rattus norvegicus	146-150
21987804-0	2011	Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.	Arginine	133-141	ORAI calcium release-activated calcium modulator 1	Homo sapiens	13-18
9136143-12	1997	The results suggest that the L-arginine/NO/cyclic GMP pathway may play a role in the regulation of the valve function in the uretero-vesical junction (UVJ).	Arginine	29-39	5'-nucleotidase, cytosolic II	Homo sapiens	50-53
21917467-1	2011	A series of optically active stereoisomers of 3,4-methanoarginine (1-4 and ent-1-ent-4) with trans/cis, D/L, and syn/anti stereochemical diversity, the side-chains of which were restricted in various special arrangements, was designed as biologically useful arginine mimetics.	Arginine	57-65	synemin	Homo sapiens	113-116
9037719-7	1997	In addition, TCH2 is enriched in Lys and Arg residues relative to other CaMs, suggesting a preference for targets which are more negatively charged.	Arginine	41-44	EF hand calcium-binding protein family	Arabidopsis thaliana	13-17
21917467-3	2011	Their biological evaluation with three isoforms of nitric oxide synthase showed that trans-3,4-methano-L-syn-arginine (2) was a good substrate, having close potency to L-arginine, and isoforms selectivities were also similar to those of l-arginine.	Arginine	168-178	synemin	Homo sapiens	64-67
21917467-3	2011	Their biological evaluation with three isoforms of nitric oxide synthase showed that trans-3,4-methano-L-syn-arginine (2) was a good substrate, having close potency to L-arginine, and isoforms selectivities were also similar to those of l-arginine.	Arginine	237-247	synemin	Homo sapiens	64-67
8940107-9	1996	Experiments using SWAP deletion mutants showed that splicing regulation of the fibronectin IIICS region and CD45 exon 4 requires a region including a carboxyl-terminal arginine/serine (R/S)-rich motif.	Arginine	168-176	protein tyrosine phosphatase receptor type C	Homo sapiens	108-112
21846720-5	2011	An arginine residue implicated in malonate binding by prokaryotic malonyl-CoA synthetases was found to be positionally conserved in animal ACSF3 enzymes and essential for activity.	Arginine	3-11	acyl-CoA synthetase family member 3	Homo sapiens	139-144
8954792-2	1996	Recent studies in animal models and in Type I arginase-deficient patients suggest that Type II arginase is inducible and may play an important role in the regulation of extra-urea cycle arginine metabolism by modulating cellular arginine concentrations.	Arginine	186-194	arginase 2	Homo sapiens	87-103
8954792-2	1996	Recent studies in animal models and in Type I arginase-deficient patients suggest that Type II arginase is inducible and may play an important role in the regulation of extra-urea cycle arginine metabolism by modulating cellular arginine concentrations.	Arginine	229-237	arginase 2	Homo sapiens	87-103
8954792-5	1996	Type II arginase may be an important part of the arginine regulatory system affecting nitric oxide synthase, arginine decarboxylase, kyotorphin synthase, and arginine-glycine transaminase activities and polyamine and proline biosynthesis.	Arginine	49-57	arginase 2	Homo sapiens	0-16
21906945-8	2011	Disruption of beta1-integrin function by active Arg results in altered distribution of selected polarity complex components mediated in part by Rap1 GTPase signaling.	Arginine	48-51	integrin subunit beta 1	Homo sapiens	14-28
20641531-7	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) is identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	130-141
9015679-2	1996	The WHO DiaMond Molecular Epidemiology Sub-Project is testing the hypothesis that the geographic differences in IDDM incidence reflect population variation in the frequency of IDDM susceptibility genes (i.e., DQA1 and DQB1 alleles with sequences coding for arginine (R) in position 52 of the DQ alpha-chain, and an amino acid other than aspartic acid (ND) in position 57 of the DQ beta-chain, respectively) using a standardized case-control design.	Arginine	257-265	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	218-222
9015680-2	1996	HLA-DQA11 and DQB1 alleles coding for arginine (R) in position 52, and an amino acid other than aspartic acid (ND) in position 57, respectively, are strong genetic markers for IDDM in Caucasians.	Arginine	38-46	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	14-18
21653880-7	2011	Insulin AUC also increased following an arginine challenge (P &lt; 0.02).	Arginine	40-48	LOC105613195	Ovis aries	0-7
8855792-5	1996	The two papillary thyroid cancer cell lines and the follicular thyroid carcinoma cell line (positive control) had transitions (CGT-&gt;CAT) in exon 8, codon 273, resulting in the replacement of arginine with histidine.	Arginine	194-202	UDP glycosyltransferase 8	Homo sapiens	127-130
8816444-0	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.	Arginine	32-40	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	158-162
8816444-6	1996	A region rich in aspartic acid, arginine, tyrosine, and glycine, termed the DRYG domain, is sufficient for self-association of eIF4B, both in vitro and in vivo, and for interaction with the p170 subunit of eIF3.	Arginine	32-40	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	206-210
21685242-5	2011	We hypothesized that TGF-beta(2)-enhanced arginase activity would decrease gas phase NO release from lung epithelial cells by limiting l-arginine availability for NOS.	Arginine	135-145	transforming growth factor beta 2	Homo sapiens	21-31
21808300-0	2011	Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.	Arginine	96-104	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	35-40
8927709-3	1996	The cell line IGR39D was transfected with the MYC oncogene, the proto-oncogene NRAS, NRAS activated by a point mutation (61-arginine) or a combination of mutated NRAS and MYC.	Arginine	124-132	NRAS proto-oncogene, GTPase	Homo sapiens	85-89
21794028-2	2011	Here we showed the effect of the proline to arginine substitution of 3BP2 in which is the most common mutation in patients with cherubism (P418R) on B-cell receptor signaling.	Arginine	44-52	SH3 domain binding protein 2	Homo sapiens	69-73
9183647-13	1996	The biological function of the central cell adhesive region requires two critical amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence, which function in synergy--for optimal binding to the alpha 5 beta 1 integrin.	Arginine	107-110	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	240-246
9183647-13	1996	The biological function of the central cell adhesive region requires two critical amino acid sequences--an Arg-Gly-Asp (RGD) sequence and a Pro-His-Ser-Arg-Asn (PHSRN) sequence, which function in synergy--for optimal binding to the alpha 5 beta 1 integrin.	Arginine	152-155	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	240-246
22007503-9	2011	CONCLUSION: Acute pancreatitis in mice induced by L-arginine is associated with calcium overload in pancreatic acinar cells induced by increased serum CCK-8.	Arginine	50-60	cholecystokinin	Mus musculus	151-154
8880912-0	1996	Binding sites for blood coagulation factor Xa and protein S involving residues 493-506 in factor Va. Inactivation due to cleavage of Factor Va (FVa) at Arg 506 by activated protein C (APC) helps to downregulate blood coagulation.	Arginine	152-155	coagulation factor X	Homo sapiens	36-45
8880912-11	1996	Possible loss of this FVa binding site for FXa due to cleavage at Arg 506 by APC may help explain why this cleavage causes 40% decrease in FVa activity and facilitates inactivation of FVa.	Arginine	66-69	coagulation factor X	Homo sapiens	43-46
8941965-8	1996	Nitric oxide production was inhibited by rhIL-4, and the L-arginine analogue antagonists of iNOS, N-G-monomethyl-L-arginine (NGMMA) and aminoguanidine (AG).	Arginine	57-67	nitric oxide synthase 2	Bos taurus	92-96
21685393-5	2011	We find also that Lys-340 is a major ubiquitination site on Ste4, as pheromone-induced ubiquitination of the protein is prevented when this residue is mutated to an arginine.	Arginine	165-173	G protein subunit beta	Saccharomyces cerevisiae S288C	60-64
21447033-6	2011	Ephrin-B3 binding to B lymphocytes is partially affected by heparin, and a basic amino acid in the extracellular juxtamembrane region, Arg-188, is here shown to be involved in this binding.	Arginine	135-138	ephrin B3	Homo sapiens	0-9
8710911-6	1996	The frequencies of alleles DQB1*0302, 0303, and 06, which share a specific amino acid sequence from position 71 to 77 (Thr-Arg-Ala-Glu-Leu-Val-Thr) were also increased (P = 0.01).	Arginine	123-126	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	27-31
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	36-44	X-ray repair cross complementing 1	Homo sapiens	30-35
8812649-2	1996	Amino acids whose side chains project from one face of the first beta-pleated sheet of MCP-1 are also involved in biological activity as is arginine-24.	Arginine	140-148	chemokine (C-C motif) ligand 2	Mus musculus	87-92
8812649-3	1996	Among C-C chemokines, position 24 is occupied by arginine only in MCP-1, -2, and -3, suggesting that arginine may be a substitution specific for monocyte chemoattractants.	Arginine	49-57	chemokine (C-C motif) ligand 2	Mus musculus	66-83
8670792-6	1996	Substitution of an arginine for the conserved lysine residue in the ATPase domain of Pxaaa1p abolished its biological activity, suggesting that Pxaaa1p is an ATPase.	Arginine	19-27	peroxisomal biogenesis factor 6	Homo sapiens	85-92
8670792-6	1996	Substitution of an arginine for the conserved lysine residue in the ATPase domain of Pxaaa1p abolished its biological activity, suggesting that Pxaaa1p is an ATPase.	Arginine	19-27	peroxisomal biogenesis factor 6	Homo sapiens	144-151
8654975-2	1996	The originally characterized Rm-resistant (RmR) TOR1-1 and TOR2-1 alleles contain an Arg in place of a conserved Ser residue, which lies adjacent to the phosphatidylinositol (PI) kinase-related domain of TOR (Ser1972 in TOR1; Ser1975 in TOR2).	Arginine	85-88	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	48-52
8654975-2	1996	The originally characterized Rm-resistant (RmR) TOR1-1 and TOR2-1 alleles contain an Arg in place of a conserved Ser residue, which lies adjacent to the phosphatidylinositol (PI) kinase-related domain of TOR (Ser1972 in TOR1; Ser1975 in TOR2).	Arginine	85-88	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	48-51
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	46-49	X-ray repair cross complementing 1	Homo sapiens	30-35
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	51-54	X-ray repair cross complementing 1	Homo sapiens	30-35
21264830-4	2011	RESULTS: Patients who had the XRCC1 arginine (Arg)/Arg polymorphism at codon 399 (399Arg/Arg) had a higher response rate to gefitinib (71% vs 36%; P = .002) and had more EGFR-mutant tumors (82% vs 29%; P = .001) than patients who had the glutamine (Gln) allele.	Arginine	51-54	X-ray repair cross complementing 1	Homo sapiens	30-35
21264830-8	2011	CONCLUSIONS: Patients with the XRCC1 399Arg/Arg, RRM1 2464GG, and ERCC1 8092CA genotypes did benefit from gefitinib.	Arginine	40-43	X-ray repair cross complementing 1	Homo sapiens	31-36
21762512-12	2011	A correlation was observed between TN-C and aggrecanase generated ARG-aggrecan fragment levels in the synovial fluid of human OA joints and in the lavage of rat joints that underwent surgical induction of OA.	Arginine	66-69	tenascin C	Homo sapiens	35-39
8766942-4	1996	A single nucleotide mutation in the tumors carrying the gsp oncogene was observed, which replaced an arginine (CGT) in the normal protein with cysteine (TGT) in eight tumors and serine (AGT) in one tumor.	Arginine	101-109	UDP glycosyltransferase 8	Homo sapiens	111-114
8667199-6	1996	The long half-life of DPLCE-Arg-Pro-Ala in serum (317 min) vs. brain (9.2 min) can be explained by the high levels of the degradative endopeptidase 24.15 (EC 3.4.24.15) in the central nervous system but not in plasma.	Arginine	28-31	thimet oligopeptidase 1	Mus musculus	134-153
21724836-1	2011	PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	0-5
21543468-6	2011	Site-directed mutagenesis identified two highly conserved arginines, R379 and R389, on the N-terminal side of the V3 stem as critical for the contact between SU and HSPG.	Arginine	58-67	syndecan 2	Homo sapiens	165-169
8631896-5	1996	The NER efficacy of TFIIH is greatly diminished or abolished upon substitution of Rad3 with the rad3 Arg-48 mutant protein or Rad25 with the rad25 Arg-392 mutant protein, respectively, thus indicating a role of the Rad3 and Rad25 DNA helicase functions in the incision of damaged DNA.	Arginine	101-104	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	82-86
8631896-5	1996	The NER efficacy of TFIIH is greatly diminished or abolished upon substitution of Rad3 with the rad3 Arg-48 mutant protein or Rad25 with the rad25 Arg-392 mutant protein, respectively, thus indicating a role of the Rad3 and Rad25 DNA helicase functions in the incision of damaged DNA.	Arginine	101-104	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	96-100
21515688-8	2011	Homology modeling and mutagenesis identified a cluster of basic amino acid residues (Lys(51), Arg(56), and Arg(80)) on the surface of human CTRC that interact with the P4" acidic residue of the inhibitor.	Arginine	94-97	chymotrypsin C	Homo sapiens	140-144
21515688-8	2011	Homology modeling and mutagenesis identified a cluster of basic amino acid residues (Lys(51), Arg(56), and Arg(80)) on the surface of human CTRC that interact with the P4" acidic residue of the inhibitor.	Arginine	107-110	chymotrypsin C	Homo sapiens	140-144
21463677-4	2011	EIF2AK4 (GCN2) is activated by depletion of l-arginine, which is used by nitric oxide synthase (NOS) during the production of NO( ).	Arginine	44-54	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	0-7
8645182-7	1996	However, PACE-4, a furin-like convertase, is much more efficient on the mouse enzyme, suggesting that ST3 protein determinants other than the conserved Ala-Arg-Asn-Arg-Gln-Lys-Arg sequence preceding the furin cleavage site are implicated in PACE-4 action.	Arginine	156-159	proprotein convertase subtilisin/kexin type 6	Mus musculus	9-15
8625852-4	1996	We demonstrate that an alternately spliced exon (encoding the sequence lysine, serine, arginine, lysine: Y site) is necessary for agrin-heparin interactions.	Arginine	87-95	agrin	Homo sapiens	130-135
21463677-4	2011	EIF2AK4 (GCN2) is activated by depletion of l-arginine, which is used by nitric oxide synthase (NOS) during the production of NO( ).	Arginine	44-54	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	9-13
21613201-14	2011	In a multiple linear regression model (R2 = 63.6%; P = 0.03), neonatal ADRB2 genotypes (p.16Arg/Arg and p.27Gln/Glu) and lower neonatal birth weight predicted lower UA lactate concentrations.	Arginine	92-95	adrenoceptor beta 2	Homo sapiens	71-76
8733054-0	1996	Arginine-164-tryptophan substitution in connexin32 associated with X linked dominant Charcot-Marie-Tooth disease.	Arginine	0-8	gap junction protein beta 1	Homo sapiens	40-50
20853182-3	2011	GIAO-B3LYP/6-31G(d) NMR calculation of a three-layer model based on the experimental structure of this TiO(2) modification gives an excellent reproduction of the experimental value (-927 ppm) within +/- 7 ppm, however, the change in relative chemical shifts, EFGs and CSA suggest that the effect of the electrostatic arginine binding might be too small for experimental detection.	Arginine	317-325	chorionic somatomammotropin hormone 1	Homo sapiens	268-271
8622305-9	1996	Moreover, as heparin concentration was reduced, Carmeda surface treatment significantly decreased generation of C3a des Arg (1 U/ml, 14,410 +/- 3558 ng/ml versus 3053 +/- 1039 ng/ml at 2 hours, p &lt; 0.05).	Arginine	120-123	complement C3	Homo sapiens	112-115
21614098-10	2011	CONCLUSION: Oral administration of arginine could improve linear growth of long bones by regulating mRNA expression of SS and Gh and inducing GH secretion, possibly via nNOS-NO-sGC-cGMP signal transduction pathway.	Arginine	35-43	nitric oxide synthase 1	Rattus norvegicus	169-173
8641983-6	1996	Mutational types of K-ras at codon 12 in PC were aspartic acid (Asp) in nine cases, both Asp and cysteine in one case, and arginine in one case.	Arginine	123-131	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
21454715-7	2011	A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression.	Arginine	23-26	inhibitor of growth family member 4	Homo sapiens	35-39
21454715-7	2011	A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression.	Arginine	62-65	inhibitor of growth family member 4	Homo sapiens	35-39
8605192-1	1996	Thrombin has trypsin-like specificity for Arg-Xaa and Lys-Xaa peptide bonds; however, it is much more specific than trypsin, cleaving far fewer peptide bonds in macromolecular substrates.	Arginine	42-45	coagulation factor II, thrombin	Bos taurus	0-8
21275939-4	2011	The condition improves with age, and in adults blistering is restricted to intertriginous areas, and severe lesions of the oral and genital mucosa and nail changes occur in the majority of described patients.2 Recent data suggested that amino-acid substitutions affecting arginines or glycines at borders of collagenic subdomains might cause this phenotype.3 We report a German patient with an unusually mild RDEB-I harbouring compound heterozygous mutations in COL7A1.	Arginine	272-281	collagen type VII alpha 1 chain	Homo sapiens	462-468
8618021-4	1996	These results disclosed a G-to-A transition within exon 73 of COL7A1, which results in a glycine-to-arginine substitution within the triple-helical domain of type VII collagen in affected individuals.	Arginine	100-108	collagen type VII alpha 1 chain	Homo sapiens	62-68
21519198-5	2011	SF2/ASF is a member of the serine/arginine (SR)-rich splicing group of factors that are necessary for spliceosome assembly and can influence alternative splicing.	Arginine	34-42	serine and arginine rich splicing factor 1	Homo sapiens	0-3
8603592-1	1996	The mutations (Trp8 --&gt; Arg and Ile15 --&gt; Thr) in the human LHbeta -subunit caused by nucleotide point mutations in the LHbeta gene were reported in women with immunologically anomalous LH and menstrual disorders.	Arginine	27-30	luteinizing hormone subunit beta	Homo sapiens	66-72
8603592-1	1996	The mutations (Trp8 --&gt; Arg and Ile15 --&gt; Thr) in the human LHbeta -subunit caused by nucleotide point mutations in the LHbeta gene were reported in women with immunologically anomalous LH and menstrual disorders.	Arginine	27-30	luteinizing hormone subunit beta	Homo sapiens	126-132
21519198-5	2011	SF2/ASF is a member of the serine/arginine (SR)-rich splicing group of factors that are necessary for spliceosome assembly and can influence alternative splicing.	Arginine	34-42	serine and arginine rich splicing factor 1	Homo sapiens	4-7
21417343-1	2011	ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL.	Arginine	20-23	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	98-102
8599935-2	1996	Achondroplasia has recently been shown to result from a Gly to Arg substitution in the transmembrane domain of the fibroblast growth factor receptor 3 (FGFR3), although the molecular consequences of this mutation have not been investigated.	Arginine	63-66	fibroblast growth factor receptor 3	Homo sapiens	115-150
8599935-2	1996	Achondroplasia has recently been shown to result from a Gly to Arg substitution in the transmembrane domain of the fibroblast growth factor receptor 3 (FGFR3), although the molecular consequences of this mutation have not been investigated.	Arginine	63-66	fibroblast growth factor receptor 3	Homo sapiens	152-157
21444773-2	2011	We have previously reported that PRMT1 methylates Forkhead box O transcription factors at two arginine residues within an Akt consensus phosphorylation motif (RxRxxS/T), and that this methylation blocks Akt-mediated phosphorylation of the transcription factors.	Arginine	94-102	protein arginine methyltransferase 1	Homo sapiens	33-38
8624806-2	1996	The peptide binding motif for RT1.Aa, determined by stabilization with synthetic peptides, included a strong preference for arginine at the peptide C terminus.	Arginine	124-132	RT1 class I, locus A	Rattus norvegicus	30-36
8624806-3	1996	Analysis of natural peptides bound to RT1.Aa by both pool sequencing and anhydrotrypsin chromatography revealed that TAP polymorphism determined the presence or absence of arginine as the peptide C-terminal residue.	Arginine	172-180	RT1 class I, locus A	Rattus norvegicus	38-44
21444773-5	2011	We show that PRMT1 specifically binds and methylates BAD at Arg-94 and Arg-96, both of which comprise the Akt consensus phosphorylation motif.	Arginine	60-63	protein arginine methyltransferase 1	Homo sapiens	13-18
21444773-5	2011	We show that PRMT1 specifically binds and methylates BAD at Arg-94 and Arg-96, both of which comprise the Akt consensus phosphorylation motif.	Arginine	71-74	protein arginine methyltransferase 1	Homo sapiens	13-18
21444773-6	2011	Consistent with the hypothesis, PRMT1-mediated methylation of these two arginine residues inhibits Akt-mediated phosphorylation of BAD at Ser-99 in vitro and in vivo.	Arginine	72-80	protein arginine methyltransferase 1	Homo sapiens	32-37
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Arginine	124-132	adrenoceptor beta 2	Homo sapiens	48-75
8637720-0	1996	Analysis of chimeric Gag-Arg/Abl molecules indicates a distinct negative regulatory role for the Arg C-terminal domain.	Arginine	97-100	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	29-32
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-40
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	116-119
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	116-119
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-40
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	116-119
8637720-5	1996	(1) The analysis of chimeric Gag-Arg/Abl molecules revealed that the Arg C-terminal domain completely abrogated Gag-Abl transforming activity and that the Abl C-terminus conferred transforming activity to Gag-Arg.	Arginine	69-72	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	116-119
8617202-4	1996	In vitro, Clk/Sty efficiently phosphorylated the SR family member ASF/SF2 on serine residues located within its serine/arginine-rich region (the RS domain).	Arginine	119-127	serine and arginine rich splicing factor 1	Homo sapiens	66-73
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Arginine	124-132	adrenoceptor beta 2	Homo sapiens	77-87
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Arginine	134-137	adrenoceptor beta 2	Homo sapiens	48-75
21572694-1	2011	BACKGROUND AND OBJECTIVES: Two polymorphisms of beta(2)-adrenergic receptor (beta(2)-AR) gene, namely the substitution from arginine (Arg) to glycine (Gly) at codon 16 and from glutamine (Gln) to glutamic (Glu) at codon 27, are linked with functional changes in the beta(2)-AR in the respiratory system even though they are not deemed to be susceptibility genes for asthma per se.	Arginine	134-137	adrenoceptor beta 2	Homo sapiens	77-87
8698744-2	1996	The prevailing type of single-base substitution at codon 201 (71.4%) corresponded to the replacement of the wild-type sequence CGT (Arg) with TGT (Cys).	Arginine	132-135	UDP glycosyltransferase 8	Homo sapiens	127-130
21237246-1	2011	Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates.	Arginine	50-58	arginyl aminopeptidase	Homo sapiens	0-16
8548458-2	1996	The Class I glutamine amidotransferase domain of GMP synthetase is found in related enzymes of the purine, pyrimidine, tryptophan, arginine, histidine and folic acid biosynthetic pathways.	Arginine	131-139	guanine monophosphate synthase	Homo sapiens	49-63
21237246-1	2011	Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates.	Arginine	50-58	arginyl aminopeptidase	Homo sapiens	18-22
21276770-0	2011	Induction of integrin beta3 in PGE2-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin.	Arginine	90-93	integrin beta 3	Mus musculus	13-27
8747525-2	1996	8-Guanidino-octanoyl-aspartic acid-phenylalanine (SC-49992), a mimetic of the tetrapeptide arginine-glycine-aspartic acid-phelylalanine, inhibits fibrinogen and vitronectin binding to GP IIb/IIIa.	Arginine	91-99	vitronectin	Homo sapiens	161-172
21262773-5	2011	Mutation of Arg-57 decreased SHP interaction with its known cofactors, Brm, mSin3A, and histone deacetylase 1 (HDAC1), but not with G9a, and decreased their recruitment to SHP target genes in mice.	Arginine	12-15	nuclear receptor subfamily 0, group B, member 2	Mus musculus	172-175
8747525-2	1996	8-Guanidino-octanoyl-aspartic acid-phenylalanine (SC-49992), a mimetic of the tetrapeptide arginine-glycine-aspartic acid-phelylalanine, inhibits fibrinogen and vitronectin binding to GP IIb/IIIa.	Arginine	91-99	integrin subunit alpha 2b	Homo sapiens	184-190
21626884-0	2011	[Role of arginine methylation in the Piwi-interacting RNA pathway].	Arginine	9-17	piwi like RNA-mediated gene silencing 1	Homo sapiens	37-41
8530455-1	1995	We have recently demonstrated that synthetic peptides modeled on the extension peptide of malate dehydrogenase can be a good substrate of mitochondrial processing peptidase and that arginine residues present at positions -2 or -3 and distant from the cleavage point were important for recognition by the enzyme (Niidome, T., Kitada, S., Shimokata, K., Ogishima, T., and Ito, A.	Arginine	182-190	malic enzyme 1	Homo sapiens	90-110
21406592-7	2011	Elevated copper corrects the ATP7B-Arg(875) phenotype.	Arginine	35-38	ATPase copper transporting beta	Homo sapiens	29-34
21406592-8	2011	Addition of only 0.5-5 muM copper triggers the exit of ATP7B-Arg(875) from the ER and restores copper delivery to the TGN.	Arginine	61-64	ATPase copper transporting beta	Homo sapiens	55-60
21406592-9	2011	Analysis of the recombinant A-domains by NMR suggests that the ER retention of ATP7B-Arg(875) is attributable to increased unfolding of the Arg(875)-containing A-domain.	Arginine	85-88	ATPase copper transporting beta	Homo sapiens	79-84
7493935-0	1995	Identification of an active site arginine in rat choline acetyltransferase by alanine scanning mutagenesis.	Arginine	33-41	choline O-acetyltransferase	Rattus norvegicus	49-74
21406592-9	2011	Analysis of the recombinant A-domains by NMR suggests that the ER retention of ATP7B-Arg(875) is attributable to increased unfolding of the Arg(875)-containing A-domain.	Arginine	140-143	ATPase copper transporting beta	Homo sapiens	79-84
7493935-1	1995	Kinetic as well as chemical modification studies have implicated the presence of an active site arginine in choline acetyltransferase, whose function is to stabilize coenzyme binding by interacting with the 3"-phosphate of the coenzyme A substrate.	Arginine	96-104	choline O-acetyltransferase	Rattus norvegicus	108-133
7493935-2	1995	In order to identify this residue seven conserved arginines in rat choline acetyltransferase were converted to alanine by site-directed mutagenesis, and the properties of these mutants were compared with the wild type enzyme.	Arginine	50-59	choline O-acetyltransferase	Rattus norvegicus	67-92
21407828-4	2011	Owing to its effects on muscle structure/function, a potential candidate is the Arg(R)577Ter(X) polymorphism (rs1815739) in ACTN3, the structural gene encoding the skeletal muscle protein alpha-actinin-3.	Arginine	80-83	actinin alpha 3	Homo sapiens	124-129
8770789-12	1995	Duodenal nutrient produced several fold increase in plasma insulin and glucagon levels that were significantly reduced by L-NNA and this reduction was partially reversed by L-Arg.	Arginine	173-178	insulin	Canis lupus familiaris	59-66
21407828-4	2011	Owing to its effects on muscle structure/function, a potential candidate is the Arg(R)577Ter(X) polymorphism (rs1815739) in ACTN3, the structural gene encoding the skeletal muscle protein alpha-actinin-3.	Arginine	80-83	actinin alpha 3	Homo sapiens	188-203
7479877-4	1995	Overexpression of MKC7 resulted in production of a membrane-associated proteolytic activity that cleaved an internally quenched fluorogenic peptide substrate on the carboxyl side of a Lys-Arg site.	Arginine	188-191	aspartyl protease	Saccharomyces cerevisiae S288C	18-22
21423288-8	2011	Treatment with L-arginine, a competitor of ADMA, lowered blood pressure and inhibited platelet aggregation concomitantly with a decrease in plasma TF level and activity in both types of hypertensive rats.	Arginine	15-25	coagulation factor III, tissue factor	Rattus norvegicus	147-149
8552445-7	1995	After 14-17 d of hyperglycemia, glucose-stimulated increase in I was even more reduced in the HG fetuses than observed at 7-10 d. Decreased insulin response to arginine also was present, although pancreatic insulin concentration was not decreased.	Arginine	160-168	LOC105613195	Ovis aries	140-147
21423288-9	2011	We also found that exogenous ADMA promoted platelet aggregation and increased TF level and (or) activity in platelet-rich plasma, an effect that was inhibited by pretreatment with L-arginine.	Arginine	180-190	coagulation factor III, tissue factor	Rattus norvegicus	78-80
21156191-2	2011	The new allele was identical to HLA-G*01:06 at exons 2, 3, and 4 with the exception of a base pair substitution at codon 169 (CAC   CGC) resulting in a coding change from histidine to arginine and codon 171 (TAC   CAC), resulting in turn in a coding change from tyrosine to histidine.	Arginine	184-192	major histocompatibility complex, class I, G	Homo sapiens	32-37
8576104-1	1995	A metalloendopeptidase (MEP) isolated from rabbit liver microsomes with substrate specificity for peptides containing Arg at the P1 and P4 positions has recently proved to be identical to soluble angiotensin-binding protein present in the cytosol.	Arginine	118-121	metalloendopeptidase	Saccharomyces cerevisiae S288C	2-22
8576104-1	1995	A metalloendopeptidase (MEP) isolated from rabbit liver microsomes with substrate specificity for peptides containing Arg at the P1 and P4 positions has recently proved to be identical to soluble angiotensin-binding protein present in the cytosol.	Arginine	118-121	neurolysin	Bos taurus	24-27
21318388-5	2011	Sequence analysis of the TS gene of representative primates revealed that arginine occurs at this relative position in all primates except a representative of prosimians.	Arginine	74-82	APC down-regulated 1	Homo sapiens	25-27
7565714-5	1995	p68 was shown to contain two Arg-containing Asp-99-dependent binding sites and one Asp-99-independent binding site which lacks an Arg.	Arginine	29-32	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-3
7565714-5	1995	p68 was shown to contain two Arg-containing Asp-99-dependent binding sites and one Asp-99-independent binding site which lacks an Arg.	Arginine	130-133	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-3
7565714-6	1995	Moreover, substitution of Asp for Thr-98 in Abl SH3 changed the binding specificity of this domain and conferred the ability to recognize Arg-containing ligands.	Arginine	138-141	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	44-47
7576102-1	1995	Murine p53 containing an Arg--&gt;Leu substitution at amino acid 172 possesses many properties characteristic of wild-type p53, including the ability to induce p21/WAF/Cip1 and apoptosis.	Arginine	25-28	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	160-163
7576102-1	1995	Murine p53 containing an Arg--&gt;Leu substitution at amino acid 172 possesses many properties characteristic of wild-type p53, including the ability to induce p21/WAF/Cip1 and apoptosis.	Arginine	25-28	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	168-172
21318388-11	2011	The data indicate that the enzyme with arginine at the position corresponding to 163 (hTS) evolved after the divergence of prosimians and simians and that substitution of lysine by arginine confers unique structural and functional properties to the enzyme expressed in simian primates.	Arginine	39-47	APC down-regulated 1	Homo sapiens	86-89
21211974-4	2011	We identified a de-novo, heterozygous, missense mutation, c.2348G&gt;C (p. Arg783Pro), in exon 21 of the MYH7 gene, which encodes slow skeletal muscle fiber/beta-cardiac myosin heavy chain protein, that replaces a highly conserved arginine with a proline.	Arginine	231-239	myosin heavy chain 7	Homo sapiens	105-109
7550341-4	1995	The deleterious effect of the Arg to Trp substitution on the catalytic activity of SDH was observed in a SDH- yeast strain transformed with mutant Fp cDNA.	Arginine	30-33	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	83-86
7550341-4	1995	The deleterious effect of the Arg to Trp substitution on the catalytic activity of SDH was observed in a SDH- yeast strain transformed with mutant Fp cDNA.	Arginine	30-33	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	105-108
7673217-9	1995	A systematic analysis of the region between the sixth cysteine residue and Leu-47 showed that the low affinity of hEGF for the chicken EGF receptor is mainly due to the presence of Arg-45.	Arginine	181-184	epidermal growth factor	Gallus gallus	115-118
7651402-5	1995	Changing the lysine residue to arginine or alanine resulted in a mutant phenotype in DNA repair and sporulation for Rad55 but not for Rad57.	Arginine	31-39	putative DNA-dependent ATPase RAD55	Saccharomyces cerevisiae S288C	116-121
7654225-4	1995	It was found that deletion of the amino terminal side of a potential proteolytic cleavage site, Arg-Arg motif, caused complete loss of Tpo"s activity, and that point-mutants lacking one of four conserved cysteine residues lost Tpo activity.	Arginine	96-99	thrombopoietin	Mus musculus	135-138
7654225-4	1995	It was found that deletion of the amino terminal side of a potential proteolytic cleavage site, Arg-Arg motif, caused complete loss of Tpo"s activity, and that point-mutants lacking one of four conserved cysteine residues lost Tpo activity.	Arginine	100-103	thrombopoietin	Mus musculus	135-138
7629159-6	1995	Also, we present the first evidence that 1) the effect of pi electrons at position 11 (L-Tyr) are important for binding to the neurotensin receptor, and 2) the length of the side chain on position 9 (L-Arg) changes binding potency.	Arginine	200-205	neurotensin receptor 2	Homo sapiens	127-154
7594769-9	1995	Urecholine and duodenal nutrient also resulted in a marked increment in plasma insulin and glucagon, the insulin (but not glucagon) increment being abolished by the pretreatment with L-NNA and reversed by the addition of L-arg.	Arginine	221-226	insulin	Canis lupus familiaris	79-86
7594769-9	1995	Urecholine and duodenal nutrient also resulted in a marked increment in plasma insulin and glucagon, the insulin (but not glucagon) increment being abolished by the pretreatment with L-NNA and reversed by the addition of L-arg.	Arginine	221-226	insulin	Canis lupus familiaris	105-112
7615511-3	1995	In this study, purified carboxypeptidase M efficiently released the COOH-terminal arginine residue from EGF with a Km = 56 microM, kcat = 388 min-1, and kcat/Km = 6.9 microM-1 min-1.	Arginine	82-90	carboxypeptidase M	Canis lupus familiaris	24-42
7608171-5	1995	The reactive center residues (Arg-Cys) are conserved in the mouse molecule, and recombinant mouse PI-6 was shown to bind thrombin, indicating that it has similar inhibitory properties to its human counterpart.	Arginine	30-33	serine (or cysteine) peptidase inhibitor, clade B, member 6a	Mus musculus	98-102
7608189-8	1995	An active site cysteine residue (Cys246; site of formation of persulfide in catalysis) and an arginine residue (Arg185; substrate binding site) in rhodanese were also conserved in MST.	Arginine	94-102	mercaptopyruvate sulfurtransferase	Rattus norvegicus	180-183
7608199-5	1995	AAP3 and AAP5 efficiently transport arginine and lysine and are involved in basic amino acid transport.	Arginine	36-44	amino acid permease 5	Arabidopsis thaliana	9-13
7790881-6	1995	Pretreatment of DRG cells with lipopolysaccharide increased basal cyclic GMP production in neuronal but not in nonneuronal cultures and facilitated stimulation of cyclic GMP production by L-arginine.	Arginine	188-198	5'-nucleotidase, cytosolic II	Homo sapiens	170-173
7481522-9	1995	Addition of L-arginine, but not D-arginine, restored the protective and hyperemic effects of CCK and pentagastrin.	Arginine	12-22	cholecystokinin	Rattus norvegicus	93-96
8590017-9	1995	This same pentamer-pentamer interaction is also present in the crystal structure of a second recombinant CTB containing an Arg--&gt;Asp substitution at residue 35, which we have determined at 2.1 A resolution.	Arginine	123-126	phosphate cytidylyltransferase 1B, choline	Homo sapiens	105-108
7777513-6	1995	The recombinant Mt-PK autophosphorylates a Ser residue and phosphorylates the synthetic peptide Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg, which contains a Ser residue in the phosphorylation site.	Arginine	100-103	DM1 protein kinase	Homo sapiens	16-21
7539253-8	1995	These observations indicate that co-induction of iNOS and AII occurs by distinct transcriptional mechanisms, AII induction could diminish NO production by decreasing L-arginine availability, and IFN-gamma can prevent AII induction.	Arginine	166-176	arginase type II	Mus musculus	109-112
7539253-8	1995	These observations indicate that co-induction of iNOS and AII occurs by distinct transcriptional mechanisms, AII induction could diminish NO production by decreasing L-arginine availability, and IFN-gamma can prevent AII induction.	Arginine	166-176	arginase type II	Mus musculus	109-112
7755581-5	1995	In contrast to the mammalian endoproteases furin and the hepatic proalbumin convertase, the Kex2 protease was adversely affected by a P4 arginine.	Arginine	137-145	kexin KEX2	Saccharomyces cerevisiae S288C	92-96
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	45-48	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	53-56	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	53-56	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	53-56	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	53-56	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7755581-6	1995	There was an 85% decrease in the cleavage of Arg-Gly-Arg-Phe-Arg-Arg-albumin compared with normal; also chicken proalbumin with an Arg-Phe-Ala-Arg processing site sequence was not a substrate for Kex2.	Arginine	53-56	kexin KEX2	Saccharomyces cerevisiae S288C	196-200
7727441-6	1995	Trypsin cleaves pro-pCPB at two sites: Arg-92 and Arg-330.	Arginine	39-42	carboxypeptidase B1	Homo sapiens	20-24
7727441-6	1995	Trypsin cleaves pro-pCPB at two sites: Arg-92 and Arg-330.	Arginine	50-53	carboxypeptidase B1	Homo sapiens	20-24
7727441-8	1995	However, cleavage at Arg-330 inactivates pCPB.	Arginine	21-24	carboxypeptidase B1	Homo sapiens	41-45
7727441-14	1995	pCPB is more specific for substrates with C-terminal arginine than those with C-terminal lysine for all the natural and synthetic peptides tested.	Arginine	53-61	carboxypeptidase B1	Homo sapiens	0-4
7543626-1	1995	Using homology-based polymerase chain reaction (PCR) amplification, we demonstrate the presence of arginine decarboxylase mRNA in tissues involved in arginine metabolism (brain, kidney, gut, adrenal gland, and liver of the rat) but not in organs (lung, heart, and spleen) in which arginine metabolism is low or absent.	Arginine	150-158	antizyme inhibitor 2	Rattus norvegicus	99-121
7492948-3	1995	The islets exposed to MBP released significantly more insulin and glucagon in a second incubation in the absence of added stimulant and in the presence of 11.5 mM arginine than the incubated, non-stimulated islets and islets initially stimulated with 15 mM glucose.	Arginine	163-171	myelin basic protein	Rattus norvegicus	22-25
7727391-3	1995	Two allosteric transitions were previously observed also in the case of the Arg-196--&gt;Ala GroEL mutant [Yifrach, O., &amp; Horovitz, A.	Arginine	76-79	heat shock protein family D (Hsp60) member 1	Homo sapiens	93-98
7727391-14	1995	Using our model, we estimate the values of the Hill coefficient for the negative cooperativity between rings in wild-type GroEL and the Arg-196--&gt;Ala mutant to be 0.003 (+/- 0.001) and 0.07 (+/- 0.02), respectively.	Arginine	136-139	heat shock protein family D (Hsp60) member 1	Homo sapiens	122-127
7727391-15	1995	The inter-ring coupling free energies in wild-type GroEL and the Arg-196--&gt;Ala mutant are -7.5 (+/- 0.4) and -3.9 (+/- 0.3) kcal mol-1, respectively.	Arginine	65-68	heat shock protein family D (Hsp60) member 1	Homo sapiens	51-56
7536925-6	1995	Specific binding of the Abl SH3 requires a longer, more proline-rich sequence but no arginine.	Arginine	85-93	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	24-27
7536925-7	1995	One clone that binds to both Src and Abl SH3 domains through a common site exhibits reversed binding orientation, in that an arginine indispensable for binding to all tested SH3 domains occurs at the C terminus.	Arginine	125-133	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	37-40
7713939-2	1995	To investigate the function of protein kinase C (PKC)-delta, we mutated its ATP binding site by converting the invariant lysine in the catalytic domain (amino acid 376) to an arginine.	Arginine	175-183	protein kinase C, delta	Mus musculus	31-59
7705834-5	1995	We also isolated ferrochelatase cDNAs containing a 18-bp insertion (part of the intron 2 sequence) between exons 2 and 3; this corresponded to six extra amino acids (YESNIR) inserted between Arg-65 and Lys-66 of the known ferrochelatase.	Arginine	191-194	ferrochelatase	Homo sapiens	17-31
7542253-7	1995	GRGDS (gly-arg-gly-asp-ser) peptides inhibited cell adhesion to intact GST-OPN, as well as to fibronectin and vitronectin.	Arginine	11-14	vitronectin	Mus musculus	110-121
7702565-12	1995	We suggest that the absence of P-5-C synthase and ornithine carbamoyltransferase in enterocytes is the metabolic basis for the nutritional requirement of arginine in the chick.	Arginine	154-162	ornithine carbamoyltransferase	Gallus gallus	50-80
7532198-4	1995	Direct sequencing of genomic DNA samples obtained from several members of each family established the substitution of a highly conserved arginine by tryptophan (R162W) in the 1A region of the alpha-helical rod domain of keratin 9.	Arginine	137-145	keratin 9	Homo sapiens	220-229
7700246-9	1995	Thus, in the TRH-R, Arg-306 appears to be important for binding but not for activation, whereas Arg-283 appears to be important for binding and activation.	Arginine	20-23	thyrotropin releasing hormone receptor	Mus musculus	13-18
8713973-5	1995	NAME prevention of the oxytocin effect was not observed when NAME was given together with L-arginine but not with D-arginine.	Arginine	90-100	oxytocin/neurophysin I prepropeptide	Homo sapiens	23-31
8531500-4	1995	Nitric oxide (NO) synthase inhibitors, NG-methyl-L-arginine (10-100 microM) and NG-nitro-L-arginine (10-100 microM) reduced cGMP accumulation induced by bradykinin in a concentration-dependent fashion, and the inhibition was reversed by L-arginine.	Arginine	49-59	kininogen 1	Bos taurus	153-163
8643356-1	1995	The Tat and Rev proteins of HIV-1 and the Rex protein of HTLV-I do not interact with their cognate ligands via a particular structural motif but instead specifically recognize RNA molecules by using agglomerations of arginine residues (1).	Arginine	217-225	Tat	Human immunodeficiency virus 1	4-7
7528740-4	1994	In a patient with PRTH, a novel mutation of a conserved arginine residue adjacent to the ninth heptad of TR-beta selectively disrupts TR homodimer formation.	Arginine	56-64	T cell receptor alpha locus	Homo sapiens	105-112
7809124-3	1994	As Arg-525 of BTK has been thought to functionally substitute for a critical lysine residue in protein-serine kinases, the mutation Arg-525-->Gln was studied and found to abrogate the tyrosine kinase activity of BTK.	Arginine	3-6	Bruton tyrosine kinase	Homo sapiens	14-17
7989760-7	1994	The location of intron/exon boundaries in the catalytic domains of the mouse and human Btk loci differs from that found in other described sub-families of intracellular PTKs, namely that of Src, Fes/Fer, Csk, and Abl/Arg.	Arginine	217-220	Bruton tyrosine kinase	Homo sapiens	87-90
7527656-10	1994	Initial rate steady-state kinetic analysis of the recombinant B-NOS showed evidence of substrate inhibition by L-arginine, which could also be seen in a partially purified preparation of B-NOS from rat cerebella.	Arginine	111-121	nitric oxide synthase 1	Rattus norvegicus	62-67
7527656-10	1994	Initial rate steady-state kinetic analysis of the recombinant B-NOS showed evidence of substrate inhibition by L-arginine, which could also be seen in a partially purified preparation of B-NOS from rat cerebella.	Arginine	111-121	nitric oxide synthase 1	Rattus norvegicus	187-192
9098450-5	1994	When DQA1-DQB1 genotypes were analysed for presence of Arg 52 (DQ alpha) and absence of Asp 57 (DQ beta), genotypes SS/SS were found significantly increased in diabetics.	Arginine	55-58	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	10-14
7957246-5	1994	Rat IGF-II purified from the rat BRL 3A cell line is a mixture of two molecules beginning with Ala-Tyr-Arg-Pro-Ser- and Tyr-Arg-Pro-Ser- [Marquardt, H., Todaro, G. J., Henderson, L. E. &amp; Oroszlan, S. (1981) J. Biol.	Arginine	103-106	insulin-like growth factor 2	Rattus norvegicus	4-10
7523218-6	1994	Glucose and arginine stimulated insulin and glucagon release from the pancreas.	Arginine	12-20	insulin	Canis lupus familiaris	32-39
7983809-3	1994	In Caucasians, this susceptibility is thought to be determined by DQA1 and DQB1 genes including the presence of arginine at position 52 of the DQ alpha chain and the absence of aspartic acid at position 57 of the DQ beta chain.	Arginine	112-120	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	75-79
7810882-5	1994	Since the higher affinity of rat vs human CNTF has been previously shown to be conferred by the arginine residue at position 63 of the rat protein, we also tested a human CNTF mutant carrying a Q63R substitution.	Arginine	96-104	ciliary neurotrophic factor	Homo sapiens	42-46
7955906-2	1994	L-Arginine is the physiological precursor of nitric oxide which induces vasodilatation and inhibits platelet aggregation by the formation of cyclic GMP.	Arginine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	148-151
8049433-0	1994	Coagulation factor XII Locarno: the functional defect is caused by the amino acid substitution Arg 353--&gt;Pro leading to loss of a kallikrein cleavage site.	Arginine	95-98	coagulation factor XII	Homo sapiens	0-22
8049245-2	1994	Exposure of HGL to trypsin led to the production of three identified fragments (H1, H2 and H3) resulting from cleavage sites at Lys-4 and Arg-229.	Arginine	138-141	relaxin 2	Homo sapiens	84-93
7531278-3	1994	A single A--&gt;G mutation in the LH beta gene of a patient presenting with hypogonadism resulted in the replacement of Gin-54 with Arg [1].	Arginine	132-135	luteinizing hormone subunit beta	Homo sapiens	34-41
7531278-4	1994	The authors also reported that an expressed mutant of hLH beta, with Arg replacing Gin-54, associated with the alpha subunit, but there was no demonstrable binding of the mutant hormone to receptor.	Arginine	69-72	luteinizing hormone subunit beta	Homo sapiens	54-62
8062517-10	1994	During L-arginine infusion, plasma cyclic GMP (the second messenger for NO) increased in the control subjects [from 5.1 (2.9) to 6.9 (2.9) nmol/l; P &lt; 0.05 versus saline] and in the diabetic patients [from 4.6 (1.8) to 5.7 (2.2) nmol/l; P = 0.09].	Arginine	7-17	5'-nucleotidase, cytosolic II	Homo sapiens	42-45
8013350-10	1994	The latter data suggest that the peptide extends C-terminally at least to residue 74, which in the POMC sequence is flanked by an Arg-Arg dibasic residue, a posttranslational cleavage site.	Arginine	130-133	proopiomelanocortin	Rattus norvegicus	99-103
8013350-10	1994	The latter data suggest that the peptide extends C-terminally at least to residue 74, which in the POMC sequence is flanked by an Arg-Arg dibasic residue, a posttranslational cleavage site.	Arginine	134-137	proopiomelanocortin	Rattus norvegicus	99-103
8020583-3	1994	In order to identify particular regions within this domain essential for filament formation and stabilization, N-terminally truncated and arginine substitution forms of vimentin were constructed via site-directed in vitro mutagenesis of murine vimentin cDNA.	Arginine	138-146	vimentin	Mus musculus	169-177
8020583-9	1994	Distinction between the assembly-promoting potentials of the two arginine residues of the N-terminal doublet was considerably facilitated by a Val389--&gt;Asp substitution toward the carboxy-end of the 2B segment of the vimentin rod domain.	Arginine	65-73	vimentin	Mus musculus	220-228
7983160-7	1994	It has some characteristics in common with the vimentin nonapeptide motif, SSYRRIFGG, including its location in the non-alpha-helical N-terminal domain and a concentration of arginine residues.	Arginine	175-183	vimentin	Mus musculus	47-55
7526282-3	1994	Further, the expression of cNOS activity in unstimulated astrocytes was confirmed by histochemical staining for NADPH diaphorase and by measuring conversion of L-arginine to L-citrulline.	Arginine	160-170	nitric oxide synthase 3	Rattus norvegicus	27-31
8203459-5	1994	Polymerase chain reaction/restriction enzyme analysis of the ApoE epsilon 3/epsilon 4 allelic site (residue 112) in the rhesus monkey revealed that the rhesus has an arginine at this site like the human epsilon 4 allele, the cynomolgus monkey, baboon, cow, pig, mouse, and rat but unlike the human epsilon 3 allele and the rabbit.	Arginine	166-174	apolipoprotein E	Macaca mulatta	61-65
8002949-8	1994	In contrast, the double mutant in which leucine residues at positions 63 and 64 of the loop C-D were changed to arginine and serine respectively partially retained its TTR-binding ability, but completely lost its affinity for the RBP receptor.	Arginine	112-120	transthyretin	Homo sapiens	168-171
8002949-8	1994	In contrast, the double mutant in which leucine residues at positions 63 and 64 of the loop C-D were changed to arginine and serine respectively partially retained its TTR-binding ability, but completely lost its affinity for the RBP receptor.	Arginine	112-120	retinol binding protein 4	Homo sapiens	230-233
8200045-6	1994	These findings suggest that NMA, an inhibitor of the L-arginine metabolic pathway, may regulate the production of specific C-X-C chemokines, IL-8 and ENA-78, during a MLR.	Arginine	53-63	C-X-C motif chemokine ligand 5	Homo sapiens	150-156
8205256-4	1994	Sequence analysis of the coding exons of the androgen receptor gene from the patients revealed a single nucleotide substitution at position 2881 in exon G, resulting in the conversion of arginine (CGT) to histidine (CAT) at amino acid position 840 in the hormone-binding domain of the androgen receptor.	Arginine	187-195	UDP glycosyltransferase 8	Homo sapiens	197-200
7915226-6	1994	One allele (NAT2(191)) contained a point mutation at nucleotide 191 [G--&gt;A (Arg--&gt;Gln)], whereas the other allele (NAT2(341/803)) contained two point mutations [341T--&gt;C (Ile--&gt;Thr); 803A--&gt;G (Lys--&gt;Arg)].	Arginine	79-82	N-acetyltransferase 2	Homo sapiens	12-16
7915226-6	1994	One allele (NAT2(191)) contained a point mutation at nucleotide 191 [G--&gt;A (Arg--&gt;Gln)], whereas the other allele (NAT2(341/803)) contained two point mutations [341T--&gt;C (Ile--&gt;Thr); 803A--&gt;G (Lys--&gt;Arg)].	Arginine	217-220	N-acetyltransferase 2	Homo sapiens	12-16
7515962-1	1994	Cathepsin B activity was demonstrated histochemically in unfixed cryostat sections of inflamed human gingiva using the 2-methoxy-4-naphthylamide (MNA) substrates Z-Val-Lys-Lys-Arg-MNA and Z-Ala-Arg-Arg-MNA with a post-azo-coupling technique.	Arginine	176-179	cathepsin B	Homo sapiens	0-11
8187056-2	1994	In DNA from one tumor we found that the histidine codon 193 (CAT) was somatically converted to arginine (CGT).	Arginine	95-103	UDP glycosyltransferase 8	Homo sapiens	105-108
8163165-4	1994	We also show that the mutations responsible for Rm resistance in four independent drr2dom alleles alter the identical aa (Ser1975--&gt;Arg) previously identified in drr1dom mutants (Ser1972--&gt;Arg or Asn).	Arginine	135-138	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	165-169
8163165-4	1994	We also show that the mutations responsible for Rm resistance in four independent drr2dom alleles alter the identical aa (Ser1975--&gt;Arg) previously identified in drr1dom mutants (Ser1972--&gt;Arg or Asn).	Arginine	195-198	phosphatidylinositol kinase-related protein kinase TOR1	Saccharomyces cerevisiae S288C	165-169
8037358-2	1994	As part of a larger study with a potential topical antiallergic drug, we measured C3a des Arg and C5a des Arg in 13 patients with seasonal allergic rhinitis and in five nonatopic controls after placebo treatment.	Arginine	90-93	complement C3	Homo sapiens	82-85
8037358-4	1994	A symptom score method was used, and in returned nasal lavage fluid, the activity of C3a des Arg and C5a des Arg was measured.	Arginine	93-96	complement C3	Homo sapiens	85-88
8037358-5	1994	We found that allergen challenge in the allergic subjects induced nasal symptoms concomitantly with increased levels of C3a des Arg and C5a des Arg (P &lt; 0.05).	Arginine	128-131	complement C3	Homo sapiens	120-123
7909256-4	1994	Sequencing analysis showed the canonical sequence (CGT, encoding an Arg residue), suggesting that the fetus was not affected.	Arginine	68-71	UDP glycosyltransferase 8	Homo sapiens	51-54
7511585-4	1994	Regeneration of arginine from citrulline is accomplished by two urea cycle enzymes: arginino-succinate synthetase (AS) and argininosuccinate lyase (AL).	Arginine	16-24	argininosuccinate lyase	Homo sapiens	123-146
9419765-11	1994	Because the same Arg-250 peptide has been affinity-alkylated in studies that targeted each of the two activities, we propose that the 3 beta-HSD and isomerase reactions are catalyzed in this region of the enzyme protein.	Arginine	17-20	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	134-144
8124712-4	1994	We also show that one of the two arginine-serine (RS)-rich domains of Tra2 is dispensable, while the other is essential for all of the in vivo functions.	Arginine	33-41	transformer 2	Drosophila melanogaster	70-74
8032213-3	1994	A panel of 21 clones deriving from the metastatic lesion Me665/2, which had a Gln--&gt;Arg substitution at codon 61 of N-RAS (N-RAS/61+), were also examined.	Arginine	87-90	NRAS proto-oncogene, GTPase	Homo sapiens	119-124
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Arginine	42-50	vitamin D receptor	Homo sapiens	14-18
8170472-9	1994	The region of hVDR between lysine-382 and arginine-402, probably the domain containing heptad 9, plays an essential role in the heterodimerization of hVDR with RAF.	Arginine	42-50	vitamin D receptor	Homo sapiens	150-154
8300582-4	1994	Mutagenesis and protease digestion studies of the recombinant HB-EGF, coupled with heparin-binding analyses of synthetic peptides, indicated that the sequences within HB-EGF mediating its interaction with heparin are located primarily in a stretch of 21 amino acids characterized by a high content of lysine and arginine residues.	Arginine	312-320	proheparin-binding EGF-like growth factor	Cricetulus griseus	167-173
8294457-8	1994	The enzyme produced such a cleavage at the Arg-Lys doublet of somatostatin 28 (Km = 43 microM), at the Arg-Arg doublet of dynorphin A (Km = 6.45 microM) and atrial natriuretic factor (Km = 6.25 microM), and at the Lys-Arg doublet of preproneurotensin-(154-170) (Km = 17.3 microM).	Arginine	103-106	natriuretic peptide A	Rattus norvegicus	157-182
8294457-8	1994	The enzyme produced such a cleavage at the Arg-Lys doublet of somatostatin 28 (Km = 43 microM), at the Arg-Arg doublet of dynorphin A (Km = 6.45 microM) and atrial natriuretic factor (Km = 6.25 microM), and at the Lys-Arg doublet of preproneurotensin-(154-170) (Km = 17.3 microM).	Arginine	103-106	natriuretic peptide A	Rattus norvegicus	157-182
7507106-3	1994	Citrulline, which is the coproduct of NOS-catalyzed metabolism of arginine, can be recycled to arginine by the action of argininosuccinate synthetase and argininosuccinate lyase, which are present at high levels in hepatocytes and renal tubular cells but normally at very low levels in other cell types such as macrophages.	Arginine	66-74	argininosuccinate lyase	Mus musculus	154-177
7507106-3	1994	Citrulline, which is the coproduct of NOS-catalyzed metabolism of arginine, can be recycled to arginine by the action of argininosuccinate synthetase and argininosuccinate lyase, which are present at high levels in hepatocytes and renal tubular cells but normally at very low levels in other cell types such as macrophages.	Arginine	95-103	argininosuccinate lyase	Mus musculus	154-177
8288644-3	1994	In the present study, we have constructed site-directed mutants of the Anthopleura xanthogrammica toxin anthopleurin B (ApB) at Arg-14 and Lys-48 to characterize the roles played by these cationic residues in the biological activity of the toxin.	Arginine	128-131	arginyl aminopeptidase (aminopeptidase B)	Mus musculus	120-123
8276803-6	1994	In this paper, we describe characterization of three mutants at each of two unique cationic sites of ApB, Arg-12 and Lys-49.	Arginine	106-109	arginyl aminopeptidase	Homo sapiens	101-104
7734147-2	1994	The hOP-1 is initially synthesized as a monomeric 50 kDa pro-protein that is dimerized, glycosylated, and then proteolytically cleaved at the Arg-Xaa-Xaa-Arg maturation site in an acidic cellular compartment before secretion into the medium.	Arginine	142-145	bone morphogenetic protein 7	Homo sapiens	4-9
7734147-2	1994	The hOP-1 is initially synthesized as a monomeric 50 kDa pro-protein that is dimerized, glycosylated, and then proteolytically cleaved at the Arg-Xaa-Xaa-Arg maturation site in an acidic cellular compartment before secretion into the medium.	Arginine	154-157	bone morphogenetic protein 7	Homo sapiens	4-9
8152339-7	1994	Similarly, when platelet GpIIb/IIIa receptors were blocked in normal platelets by the tripeptide Arg-Gly-Asp (RGD) or the tetrapeptide Arg-Gly-Asp-Ser (RGDS) at 10(-3) M, agonist-induced platelet aggregation and fibrinogen binding were blocked, but platelet PAI-1 release was not blocked.	Arginine	97-100	integrin subunit alpha 2b	Homo sapiens	25-30
8118603-6	1993	Their details were GTC (valine) to TTC (phenylalanine) at codon 157 in exon 5, and CGT (arginine) to CAT (histidine) at codon 273 in exon 8.	Arginine	88-96	UDP glycosyltransferase 8	Homo sapiens	83-86
7902568-8	1993	The mutation at position 723, which changes the amino acid sequence from Arg to Cys at residue 220, showed complete association with the PGM1 2/1 protein polymorphism: DNA from individuals showing the PGM1 1 isozyme carried the Arg codon CGT, whereas individuals showing the PGM1 2 isozyme carried the Cys codon TGT.	Arginine	73-76	UDP glycosyltransferase 8	Homo sapiens	238-241
8219225-5	1993	Within this region, the mu-PAR domain 1 could be minimally humanized to bind human pro-u-PA by a substitution of as few as four of the six nonconserved residues, thereby identifying the residues arginine-2, lysine-7, threonine-8, and glycine-10 as important in determining binding specificity.	Arginine	195-203	jumping translocation breakpoint	Homo sapiens	27-30
8224196-4	1993	Damage also resulted following induction of nitric oxide synthase by the cytokine interleukin-1 beta in both islets and HIT-T15 cells and was prevented by replacing the substrate, arginine, with nitromonomethyl arginine.	Arginine	180-188	interleukin-1 beta	Mesocricetus auratus	82-100
8375398-1	1993	Two antibacterial peptides, cecropin P1 and PR-39 (39-residue proline/arginine-rich peptide), from the upper part of pig small intestine have previously been isolated and characterized.	Arginine	70-78	antibacterial protein PR-39	Sus scrofa	28-49
8143212-7	1993	The data showed that the 2% of total energy supplied by arginine was found to significantly enhance the T lymphocyte response to PHA, CD4 phenotype expression, CD4/CD8 ratio, IL-2 production and IL-2 receptor expression, as compared with the control group.	Arginine	56-64	CD8a molecule	Homo sapiens	164-167
8102597-6	1993	We sequenced the NAT2 gene for several discordant slow-acetylator individuals and found a G > A base-change in codon 64 that caused a Arg > Glu amino acid substitution.	Arginine	134-137	N-acetyltransferase 2	Homo sapiens	17-21
8354270-5	1993	Rat HES-2 protein has a basic HLH domain homologous to h and E(spl) as well as the carboxy-terminal Trp-Arg-Pro-Trp sequence conserved among this family.	Arginine	104-107	hes family bHLH transcription factor 2	Rattus norvegicus	4-9
8400548-1	1993	Previous studies have shown that exogenous glycosphingolipids (GSLs) inhibit the adhesion of thrombin-activated platelets (TAP) to polystyrene plates coated with various RGD-ligands (where RGD is the peptide sequence Arg-Gly-Asp), suggesting that GSLs can modulate the platelet integrin receptor glycoprotein IIb-IIIa.	Arginine	217-220	coagulation factor II, thrombin	Bos taurus	93-101
8325868-0	1993	An amino acid switch (Gly281--&gt;Arg) within the "hinge" region of the tryptophan synthase beta subunit creates a novel cleavage site for the OmpT protease and selectively diminishes affinity toward a specific monoclonal antibody.	Arginine	34-37	outer membrane protease	Escherichia coli	143-147
8325868-8	1993	The Arg-Met peptide bond has not previously been reported to be susceptible to cleavage by the OmpT protease.	Arginine	4-7	outer membrane protease	Escherichia coli	95-99
8323294-5	1993	Like the other vertebrate SCPx proteins, the chicken protein contains a conserved Arg-Gly-Asp sequence and a cysteine residue in the N-terminus that aligns with the active site cysteine of Escherichia coli 3-ketoacyl-CoA thiolase, a protein that was previously shown to be homologous to vertebrate SCPx.	Arginine	82-85	sterol carrier protein 2	Gallus gallus	26-30
8514037-5	1993	RESULTS: The CN II patients were found to be homozygous for a nucleotide shift in the unique region of B-UGT1, changing a arginine into a tryptophan, and also for a nucleotide shift in the unique region of B-UGT2, changing a leucine into a valine.	Arginine	122-130	5'-nucleotidase, cytosolic II	Homo sapiens	13-18
8485128-7	1993	Infrared spectroscopy of CO2 bound to either wild-type CA II or the Leu-198--&gt;Arg variant indicates that the Arg substitution both decreases the affinity and alters the position of CO2 binding, suggesting that the hydrophobic pocket forms the CO2 binding site in CA II.	Arginine	81-84	carbonic anhydrase 2	Homo sapiens	266-271
8485128-7	1993	Infrared spectroscopy of CO2 bound to either wild-type CA II or the Leu-198--&gt;Arg variant indicates that the Arg substitution both decreases the affinity and alters the position of CO2 binding, suggesting that the hydrophobic pocket forms the CO2 binding site in CA II.	Arginine	112-115	carbonic anhydrase 2	Homo sapiens	55-60
8485128-7	1993	Infrared spectroscopy of CO2 bound to either wild-type CA II or the Leu-198--&gt;Arg variant indicates that the Arg substitution both decreases the affinity and alters the position of CO2 binding, suggesting that the hydrophobic pocket forms the CO2 binding site in CA II.	Arginine	112-115	carbonic anhydrase 2	Homo sapiens	266-271
8320037-9	1993	The nucleotide sequence analyses demonstrated that the codon CGT for -2 Arg was mutated to CAT for His.	Arginine	72-75	UDP glycosyltransferase 8	Homo sapiens	61-64
8428938-1	1993	Evidence for reduced cholesterol efflux promotion by apoA-I(Pro165--&gt;Arg).	Arginine	72-75	apolipoprotein A-I	Mus musculus	53-59
8428938-9	1993	In the present study, all apoA-I.DMPC complexes except those containing apoA-I(Pro165--&gt;Arg) promoted cholesterol efflux as effectively as those containing normal apoA-I.	Arginine	91-94	apolipoprotein A-I	Mus musculus	72-78
8428938-9	1993	In the present study, all apoA-I.DMPC complexes except those containing apoA-I(Pro165--&gt;Arg) promoted cholesterol efflux as effectively as those containing normal apoA-I.	Arginine	91-94	apolipoprotein A-I	Mus musculus	72-78
8428938-10	1993	Cholesterol efflux from adipocytes obtained after 180 min of incubation with apoA-I(Pro165--&gt;Arg).DMPC complexes was decreased by 30% although this variant was bound to adipocytes with normal affinity.	Arginine	96-99	apolipoprotein A-I	Mus musculus	77-83
8093615-2	1993	At variance with platelet alpha IIb beta 3 or endothelial cell alpha v beta 3 integrins, CD11b/CD18 interacts with a approximately 30-kDa plasmic fragment D (D30) of fibrinogen that lacks the Arg-Gly-Asp sequences in the A alpha chain and the carboxyl terminus of the gamma chain.	Arginine	192-195	integrin subunit alpha M	Homo sapiens	89-94
8419368-1	1993	Human liver alcohol dehydrogenase isoenzymes beta 1 beta 1 and beta 2 beta 2, in which position 47 in the coenzyme binding domain is an arginine or histidine, respectively, differ remarkably in steady-state kinetics.	Arginine	136-144	aldo-keto reductase family 1 member A1	Homo sapiens	12-33
8094610-2	1993	To look for a possible functional correlate to this finding basal and arginine stimulated plasma somatostatin and serum C peptide concentrations in eight insulin treated patients with cystic fibrosis and eight normal male controls were measured.	Arginine	70-78	somatostatin	Homo sapiens	97-109
8417803-0	1993	Arg-Gly-Asp-dependent occupancy of GPIIb/IIIa by applaggin: evidence for internalization and cycling of a platelet integrin.	Arginine	0-3	integrin subunit alpha 2b	Homo sapiens	35-40
7679657-7	1993	Both low- and high-dose interleukin-1 beta treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP.	Arginine	115-123	5'-nucleotidase, cytosolic II	Homo sapiens	155-158
8436445-5	1993	In the preparation of the beta-glucosylated analogue the BOP procedure was used for reacting Boc-[Glc(Ac)4 beta]Hyp-OH with H-Arg(NO)2-OBzl was well as for the final coupling to tetrapeptide.	Arginine	124-129	SET and MYND domain containing 1	Mus musculus	57-60
8280370-5	1993	In two subsequent tumorigenic revertants derived from Rev-1, we again found the Arg--&gt;Gln substitution at residue 246 that was found initially in the T-60 cells.	Arginine	80-83	REV1, DNA directed polymerase	Mus musculus	54-59
21135101-5	2011	One in vitro generated LT mutant (LTK4R), in which the lysine at position 4 of the A subunit was replaced by arginine, showed most of the LT4 features with an ~10-fold reduction of the cytotonic effects, ADP-ribosylation activity, and accumulation of intracellular cAMP in Y1 cells.	Arginine	109-117	Leucine transport, high	Homo sapiens	23-25
21347367-4	2011	Analyzing the three dynamic trajectories (Aurora A-ATP, Aurora A-ADP, and Aurora A-ADP-TPX2) at the residue level, for the first time we find two TPX2-dependent switches, i.e., switch-1 (Lys-143) and switch-2 (Arg-180), which are tightly associated with Aurora A activation.	Arginine	210-213	TPX2 microtubule nucleation factor	Homo sapiens	87-91
1340470-1	1992	An RNA-binding protein gene (rbp1) from Drosophila melanogaster, encoding an RNA recognition motif and an Arg-Ser rich (RS) domain, has been characterized.	Arginine	106-109	RNA-binding protein 1	Drosophila melanogaster	29-33
21347367-4	2011	Analyzing the three dynamic trajectories (Aurora A-ATP, Aurora A-ADP, and Aurora A-ADP-TPX2) at the residue level, for the first time we find two TPX2-dependent switches, i.e., switch-1 (Lys-143) and switch-2 (Arg-180), which are tightly associated with Aurora A activation.	Arginine	210-213	TPX2 microtubule nucleation factor	Homo sapiens	146-150
1385407-5	1992	Conservative substitutions of 2 highly conserved basic residues in the SH2-N domain, an arginine and a histidine, resulted in complete loss of receptor and p62 binding, whereas other basic residues, and residues at variable SH2 sites, were more tolerant of substitution.	Arginine	88-96	nucleoporin 62	Homo sapiens	156-159
21378360-4	2011	RESULTS: XRCC1 codon 194 Trp carriers (Trp/Trp + Arg/Trp) held a significantly higher risk of venous invasion (OR = 3.76, 95%CI = 1.05-13.51, p = 0.043).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	9-14
1429654-1	1992	Conserved lysines of mouse ornithine decarboxylase were individually mutated to arginines.	Arginine	80-89	ornithine decarboxylase, structural 1	Mus musculus	27-50
21187067-0	2011	TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.	Arginine	92-100	protein arginine methyltransferase 1	Homo sapiens	8-13
1288768-2	1992	As early as after 10 days of storage under normal blood bank conditions the elevations of the concentrations of C3a-desArg and C4a-des-Arg were highly significant.	Arginine	119-122	complement C3	Homo sapiens	112-115
21187067-4	2011	We analyzed the methylation status of endogenous TLS and demonstrated that TLS was arginine-methylated by PRMT1.	Arginine	83-91	protein arginine methyltransferase 1	Homo sapiens	106-111
21187067-7	2011	Further analysis using a catalytic-dead PRMT1 or methylation inhibitor both showed that the synergistic transcriptional activation was mediated by TLS arginine-methylation.	Arginine	151-159	protein arginine methyltransferase 1	Homo sapiens	40-45
20966070-6	2011	Structural modeling highlights Ser-34 and Arg-98 as residues important for the assembly of the Myddosome, a death domain (DD) post-receptor complex involving the DD of MyD88, IRAK4, and IRAK2 or IRAK1.	Arginine	42-45	interleukin 1 receptor associated kinase 4	Homo sapiens	175-180
1527012-8	1992	Active GPIIb-IIIa was heavily degraded by Arg-C, whereas inactive GPIIb-IIIa was highly resistant to degradation.	Arginine	42-45	integrin subunit alpha 2b	Homo sapiens	7-12
22393969-10	2011	The XRCC1 codon Arg/Gln was this associated with an increased risk of HCC, especially in patients above 50 years old and/or with a drinking habit.	Arginine	16-19	X-ray repair cross complementing 1	Homo sapiens	4-9
20666624-7	2011	We also observed an association between the ITGAM His/His and Arg/His genotypes and renal symptoms in the course of SLE OR = 2.975 (95% CI = 1.478-5.988; p = 0.0023).	Arginine	62-65	integrin subunit alpha M	Homo sapiens	44-49
21959333-4	2011	In analysis of the genotypes combination, only the carriers of both beta2AR Arg/Arg and UCP1 G/G genotypes had significantly higher waist to hip ratio (p=0.014).	Arginine	76-79	adrenoceptor beta 2	Homo sapiens	68-75
21959333-4	2011	In analysis of the genotypes combination, only the carriers of both beta2AR Arg/Arg and UCP1 G/G genotypes had significantly higher waist to hip ratio (p=0.014).	Arginine	80-83	adrenoceptor beta 2	Homo sapiens	68-75
21155690-11	2011	Common features of all of them include a hydrogen bond donor-acceptor pair that makes contact with the backbone CO- and NH- bonds of Arg 63 residue on GK and two hydrophobic groups.	Arginine	133-136	glucokinase	Homo sapiens	151-153
22553674-0	2011	Transthyretin Arg-83 mutation in vitreous amyloidosis.	Arginine	14-17	transthyretin	Homo sapiens	0-13
22553674-7	2011	Bi-directional sequencing of the transthyretin gene revealed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (transthyretin Arg-83).	Arginine	164-172	transthyretin	Homo sapiens	33-46
22553674-7	2011	Bi-directional sequencing of the transthyretin gene revealed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (transthyretin Arg-83).	Arginine	164-172	transthyretin	Homo sapiens	174-187
22553674-7	2011	Bi-directional sequencing of the transthyretin gene revealed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (transthyretin Arg-83).	Arginine	188-191	transthyretin	Homo sapiens	33-46
22553674-7	2011	Bi-directional sequencing of the transthyretin gene revealed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (transthyretin Arg-83).	Arginine	188-191	transthyretin	Homo sapiens	174-187
20364408-7	2011	In contrast, the combined genotype Arg/Arg-Ser/Ser of XRCC1/OGG1 (OR 0.40) as well as the Ser/Ser-Tyr/Tyr of OGG1/MUTYH (OR 0.43) played a protective role against this malignant disease.	Arginine	35-38	X-ray repair cross complementing 1	Homo sapiens	54-59
20364408-7	2011	In contrast, the combined genotype Arg/Arg-Ser/Ser of XRCC1/OGG1 (OR 0.40) as well as the Ser/Ser-Tyr/Tyr of OGG1/MUTYH (OR 0.43) played a protective role against this malignant disease.	Arginine	39-42	X-ray repair cross complementing 1	Homo sapiens	54-59
21118350-12	2011	They are abolished completely by mutation of the arginine residue within the invariable penta-amino acid motif LENRV, as present in the nonfunctional Arabidopsis nim1-4 allele.	Arginine	49-57	regulatory protein (NPR1)	Arabidopsis thaliana	162-166
22073228-0	2011	N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes.	Arginine	11-20	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	68-73
22073228-9	2011	Ionic currents resulting from co-transfection of a KCNE1 mutant with arginine substitutions ("38G-3xA") were comparable to currents evoked from cells transfected with an N-terminally truncated KCNE1-construct ("Delta1-38").	Arginine	69-77	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	51-56
21097700-5	2010	PRMT5 encodes a type II protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine residues (Rsme2).	Arginine	32-40	SHK1 binding protein 1	Arabidopsis thaliana	0-5
21151933-3	2010	We reveal here a novel mechanism by which Salmonella exploit mCAT1 and mCAT2B to acquire host arginine towards its own intracellular growth within antigen presenting cells.	Arginine	94-102	dominant cataract 2	Mus musculus	71-76
21080372-0	2010	Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins.	Arginine	89-97	protein arginine methyltransferase 1	Homo sapiens	57-62
21080485-6	2010	Further, significant reduction of arginine modification in CstF2 and chaperone containing TCP1 subunit 7 was observed in prematurely senescent fibroblasts, induced by treatment with adenosine dialdehyde, a transmethylation inhibitor, or subcytotoxic concentration of H(2)O(2).	Arginine	34-42	cleavage stimulation factor subunit 2	Homo sapiens	59-64
21079036-3	2010	Kisspeptins are members of the Arg-Phe amide family of peptides, which have been identified as endogenous ligands for a G-protein-coupled receptor encoded by a gene originally called GPR54 (also known as AXOR12 or hOT7T175).	Arginine	31-34	KISS1 receptor	Mus musculus	183-188
20833961-4	2010	In A10 cells, ANG II (1 muM) also increased B(1)R mRNA expression at 3 h and the activation of induced B(1)R with the agonist [Sar-d-Phe(8)]-des-Arg(9)-BK (10 nM, 5 min) significantly enhanced mitogen-activated protein kinase (MAPK1/2) phosphorylation.	Arginine	145-148	angiogenin	Rattus norvegicus	14-17
20653567-2	2010	Here, we address the question of whether endogenous levels of key Arg metabolic enzymes [catabolic: arginases, ARG1 (arginase type 1) and ARG2 (arginase type 2), and anabolic: OTC (ornithine transcarbamylase) and ASS (argininosuccinate synthetase)] affect cellular responses to arginine deprivation in vitro.	Arginine	66-69	arginase 2	Homo sapiens	138-142
20713692-0	2010	Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines.	Arginine	76-85	histone H2B	Saccharomyces cerevisiae S288C	16-27
20713692-3	2010	In this study, we found two arginine residues within histone H2B, which are specifically required to maintain either the telomeric or the rDNA silenct chromatin.	Arginine	28-36	histone H2B	Saccharomyces cerevisiae S288C	53-64
20942588-4	2010	Genetic analysis revealed that all tested patients from the family carried a novel c.186C>G mutation in the GJB1 gene, resulting in substitution of Serine for Arginine in the first extracellular loop domain of Cx32 protein.	Arginine	159-167	gap junction protein beta 1	Homo sapiens	108-112
20942588-4	2010	Genetic analysis revealed that all tested patients from the family carried a novel c.186C>G mutation in the GJB1 gene, resulting in substitution of Serine for Arginine in the first extracellular loop domain of Cx32 protein.	Arginine	159-167	gap junction protein beta 1	Homo sapiens	210-214
20833801-2	2010	In this study, the ldcA gene (lysine decarboxylase A; PA1818), previously identified as a member of the ArgR regulon of L-arginine metabolism, was found essential for L-lysine catabolism in this organism.	Arginine	120-130	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	104-108
20934468-5	2010	Here we fused the elastin derived peptide Ala-Pro-Gly-Val-Gly-Val (APGVGV) with the cell adhesive peptides, Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD).	Arginine	140-143	elastin	Homo sapiens	18-25
20823272-9	2010	Together, these data support a model whereby arginine methylation modulates dynamic associations between SR-like protein and pre-mRNA splicing factor to promote target specificity in splicing.	Arginine	45-53	pinin, desmosome associated protein	Homo sapiens	105-120
21048924-8	2010	RESULTS: The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively.	Arginine	21-24	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21048924-8	2010	RESULTS: The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively.	Arginine	176-179	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21048924-8	2010	RESULTS: The ADH1B*47Arg allele was found to be associated to increased risk of ESCC, with the odds ratios (OR) being 1.62 (95% CI: 1.49-1.76) and 3.86 (2.96-5.03) for the His/Arg and the Arg/Arg genotypes, respectively.	Arginine	176-179	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	13-18
21048924-10	2010	Statistical tests also showed gene-gene interaction of ADH1B Arg+ with ALDH2 Lys+ can bring more risk to ESCC (OR  = 13.46, 95% CI: 2.32-78.07).	Arginine	61-64	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	55-60
20603179-9	2010	The binding mode of TLM to DDO was validated further by site-directed mutagenesis of an active site residue, Arg-237.	Arginine	109-112	D-aspartate oxidase	Mus musculus	27-30
20737438-2	2010	In spreading fibroblasts, the Abl family kinases, Abl and Arg, primarily localize to the nucleus and cell periphery, respectively.	Arginine	58-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	30-33
20599604-3	2010	In the present study we initially investigated the in vitro effect of arginine, homoarginine, N-acetylarginine and argininic acid on acetylcholinesterase and butyrylcholinesterase in hippocampus and serum of 15-, 30- and 60-day-old rats.	Arginine	70-78	butyrylcholinesterase	Rattus norvegicus	158-179
20545900-2	2010	It differs from B*51:01:01(B*510101) by one nucleotide substitution at codon 145 (CGC  GGC), resulting to one amino acid change (Arginine to Glycine).	Arginine	129-137	gamma-glutamylcyclotransferase	Homo sapiens	87-90
20840750-7	2010	Moreover, using oligonucleotide-based degenerate PCR, we discovered that mutation of Arg-501 and Lys-503 of mCRY2 within this C-terminal region totally abolishes interaction with PER2.	Arginine	85-88	period circadian regulator 2	Homo sapiens	179-183
1327594-0	1992	L-arginine infusion induces hypotension and diuresis/natriuresis with concomitant increased urinary excretion of nitrite/nitrate and cyclic GMP in humans.	Arginine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	140-143
20711410-12	2010	Furthermore, ARG1 and ARG2 were enzymatically active and their decreased expression by siRNA resulted in reduced overall arginase activity and l-arginine metabolism.	Arginine	143-153	arginase 2	Homo sapiens	22-26
20363363-6	2010	l-Arginine augmented and prolonged cold-induced increase of eNOS, inducible NOS and thermogenic-molecules expression, IBAT nerve supply, vascularity, hyperplasia and mitochondrial-remodeling, while L-NAME had an opposite effects.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	60-64
1354193-9	1992	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.	Arginine	120-123	major histocompatibility complex, class II, DR beta 4	Homo sapiens	102-105
1354193-9	1992	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among the Japanese.	Arginine	120-123	major histocompatibility complex, class II, DR beta 4	Homo sapiens	142-145
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	43-51	somatostatin	Homo sapiens	173-185
20660662-1	2010	Hypokalemic periodic paralysis and normokalemic periodic paralysis are caused by mutations of the gating charge-carrying arginine residues in skeletal muscle Na(V)1.4 channels, which induce gating pore current through the mutant voltage sensor domains.	Arginine	121-129	immunoglobulin lambda variable 2-14	Homo sapiens	158-166
1355580-2	1992	The aim of our study was to verify whether arginine ([Arg] 30 g intravenously [IV] in 30 minutes), a well-known GH secretagogue likely acting via inhibition of hypothalamic somatostatin release, counteracts the inhibitory effect of oral glucose (OG) administration (100 mg orally) on the GH response to GHRH (1 micrograms/kg IV bolus) in seven normal subjects (aged 20 to 30 years).	Arginine	54-57	somatostatin	Homo sapiens	173-185
1518046-5	1992	The D-stereoisomer of NAPAP and the L-stereoisomer of MQPA bind to thrombin with very similar conformations, as previously inferred from their binding to bovine trypsin; the arginine side-chain of the latter inserts into the specificity pocket in a "non-canonical" manner.	Arginine	174-182	coagulation factor II, thrombin	Bos taurus	67-75
20453884-8	2010	An hTERT mutant with all five lysine residues at the N-terminus of hTERT that mutated to arginine became resistant to Hdm2-mediated ubiquitination and degradation.	Arginine	89-97	MDM2 proto-oncogene	Homo sapiens	118-122
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	163-166	kexin KEX2	Saccharomyces cerevisiae S288C	40-44
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	173-176	kexin KEX2	Saccharomyces cerevisiae S288C	40-44
1644796-1	1992	Furin, a mammalian homolog of the yeast Kex2 protease, is associated with Golgi membranes and is involved in cleavage of precursor proteins at sites marked by the Arg-X-Lys/Arg-Arg (RXK/RR) motif.	Arginine	173-176	kexin KEX2	Saccharomyces cerevisiae S288C	40-44
20180859-5	2010	The males bearing alcoholism-susceptible homozygotes at both loci (inactive ADH1B Arg/Arg and active ALDH2 Glu/Glu genotypes) have a 10 times greater risk for suicide compared with the males bearing alcoholism-protective homozygotes at both loci.	Arginine	82-85	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	76-81
1379228-10	1992	4) Hybrid depletion with an rBAT antisense oligonucleotide greatly prevents the mRNA-dependent induction of uptake of L-cystine (greater than 90%) and of L-leucine (approximately 75%); it reduces to about 50% the induction of L-arginine uptake.	Arginine	226-236	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	28-32
1379228-12	1992	6) The mRNA-induced component of L-arginine uptake which is resistant to rBAT hybrid depletion is inhibited by L-homoserine, only in the presence of sodium; thus, it is related to a system y(+)-like activity.	Arginine	33-43	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	73-77
20477940-8	2010	Moving the arginine residue from TM8 to HP1 in EAAT1 results in a transporter that has significantly increased affinity for both glutamate and aspartate and is K(+) independent.	Arginine	11-19	tetraspanin 16	Homo sapiens	33-36
1322886-4	1992	In addition, we show that the amino acids at positions 1 and 2 of the recognition helix of CLP are identical to the amino acids at positions 1 and 2 of the recognition helix of CAP:i.e., Arg at position 1 and Glu at position 2.	Arginine	187-190	catabolite gene activator protein	Escherichia coli	177-180
20477940-9	2010	Conversely, moving the arginine residue from HP1 to TM8 in Glt(Ph) results in a transporter that has reduced affinity for aspartate.	Arginine	23-31	tetraspanin 16	Homo sapiens	52-55
1358601-5	1992	Sequence analysis of the DNAs extracted from paraffin sections of pituitary, parathyroid, and pancreas tumors demonstrated the substitution of thymidine for cytidine in codon 201 of the Gs alpha gene that resulted in replacement of arginine (CGT) with cysteine (TGT) only in the pituitary adenoma, but not in the parathyroid and pancreas tumors.	Arginine	232-240	UDP glycosyltransferase 8	Homo sapiens	242-245
20614009-5	2010	METHODS/PRINCIPAL FINDINGS: Here we demonstrate for the first time that BRCA1 is methylated both in breast cancer cell lines and breast cancer tumor samples at arginine and lysine residues through immunoprecipitation and western blot analysis.	Arginine	160-168	BRCA1 DNA repair associated	Homo sapiens	72-77
1577761-0	1992	Arginine residues involved in binding of tetrahydrofolate to sheep liver serine hydroxymethyltransferase.	Arginine	0-8	serine hydroxymethyltransferase, cytosolic	Ovis aries	73-104
1577761-1	1992	The arginine residue(s) necessary for tetrahydrofolate binding to sheep liver serine hydroxymethyltransferase were located by phenylglyoxal modification.	Arginine	4-12	serine hydroxymethyltransferase, cytosolic	Ovis aries	78-109
1577761-8	1992	These results demonstrate the requirement of specific arginine residues for the interaction of tetrahydrofolate with sheep liver serine hydroxymethyltransferase.	Arginine	54-62	serine hydroxymethyltransferase, cytosolic	Ovis aries	129-160
20614009-6	2010	Arginine methylation by PRMT1 was observed in vitro and the region of BRCA1 504-802 shown to be highly methylated.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	24-29
21038778-1	2010	The genetic polymorphisms at the 16th (Arg--&gt; Gly) and 27th (Gln--&gt;Glu) amino acid positions of the beta2-adrenergic receptor (ADRB2) may be linked to various asthma-related phenotypes.	Arginine	39-42	adrenoceptor beta 2	Homo sapiens	106-131
20471275-2	2010	Our previous studies showed that the high-affinity HSP47-binding motif in the collagen triple helix is Xaa-(Thr/Pro)-Gly-Xaa-Arg-Gly.	Arginine	125-128	serpin family H member 1	Homo sapiens	51-56
1374686-3	1992	Recombinant human p62 purified from insect Sf9 cells binds to DNA and to mRNA and, like many proteins involved in mRNA processing, recombinant p62 is modified by dimethylation on multiple arginine residues.	Arginine	188-196	nucleoporin 62	Homo sapiens	18-21
1374686-3	1992	Recombinant human p62 purified from insect Sf9 cells binds to DNA and to mRNA and, like many proteins involved in mRNA processing, recombinant p62 is modified by dimethylation on multiple arginine residues.	Arginine	188-196	nucleoporin 62	Homo sapiens	143-146
1569192-4	1992	A G to T transition at nucleotide 10038 results in the substitution of Met to an Arg, converting alpha 1-AT into an Arg-Ser protease inhibitor (serpin) that inhibited thrombin and Factor Xa more effectively than antithrombin III.	Arginine	81-84	coagulation factor X	Homo sapiens	180-189
20471275-4	2010	Results obtained from in vitro binding assays indicated that HSP47 detects the side-chain structure of Arg at the Yaa(0)-position, while the Yaa(-3) amino acid serves as the secondary recognition site that affects affinity to HSP47.	Arginine	103-106	serpin family H member 1	Homo sapiens	61-66
20218899-5	2010	We found an increased risk of bladder cancer associated with the XRCC1 194Trp/Trp and 280Arg/His genotypes (adjusted odds ratio = 3.90, 95% confidence interval = 1.69-8.98 for 194Trp/Trp and 2.53, 1.67-3.83 for 280Arg/His) compared with the 194Arg/Arg and 280Arg/Arg genotypes, respectively.	Arginine	214-217	X-ray repair cross complementing 1	Homo sapiens	65-70
1421803-1	1992	Analysis of well resolved x-ray crystal structure data of proteins (Brookhaven protein data bank) has been combined with molecular mechanics methods using MM2, to determine possible bioactive conformations for the sequence Arg-Gly-Asp, which is believed to be involved in interactions of adhesive proteins with the glycoprotein complexes on activated platelets.	Arginine	223-226	PNMA family member 2	Homo sapiens	155-158
20642000-4	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
20200225-4	2010	Mutation analyses of MyoK revealed that both a C-terminal farnesylation membrane anchor and a Gly-Pro-Arg domain that interacts with profilin and Abp1 were necessary for proper localization in the furrow and efficient phagocytosis.	Arginine	102-105	profilin	Saccharomyces cerevisiae S288C	133-141
1315534-4	1992	An extension of TRAP1-4 by an additional Arg-Asn segment yielded the most potent agonist among the series (TRAP1-6, EC50 = 1.3 microM).	Arginine	41-44	TNF receptor associated protein 1	Homo sapiens	107-114
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Arginine	283-286	drug-responsive transcription factor PDR3	Saccharomyces cerevisiae S288C	102-106
1349863-4	1992	This shows that the cysteine protease is highly specific for paired arginine residues.	Arginine	68-76	cathepsin B	Homo sapiens	20-37
20146400-4	2010	Different levels of complementation of cycloheximide hypersensitivity and expression of autoregulated PDR3 and its PDR5 target in the pdr1Deltapdr3Delta mutant strain, ranging from that of the wild-type to loss-of-function alleles, were observed in pdr3 mutants containing Pro, Glu, Arg, Asn, Ser, Leu, Phe, Ile or Tyr instead of Asp853 in Pdr3p.	Arginine	283-286	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	115-119
20449481-1	2010	Antimicrobially active cycloundecapeptides related to gramicidin S, cyclo(-Val1-Orn2-Leu3-X4-D-Phe5-Pro6-Val7-Orn8- Leu9-D-Phe10-Pro11-) (X= Leu (1), Ala (2), Orn (3), Lys (4) and Arg (5)), were synthesized.	Arginine	180-183	CD7 molecule	Homo sapiens	116-120
1557353-3	1992	The PR264 polypeptide, which contains a typical ribonucleoprotein 80 and an arginine/serine-rich domain, is highly homologous to the Drosophila splicing regulators tra, tra-2, and su(wa) and to the human alternative splicing factor ASF/SF2.	Arginine	76-84	transformer 2	Drosophila melanogaster	169-174
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	104-107	kexin KEX2	Saccharomyces cerevisiae S288C	47-51
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	114-117	kexin KEX2	Saccharomyces cerevisiae S288C	47-51
1587790-0	1992	Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.	Arginine	114-117	kexin KEX2	Saccharomyces cerevisiae S288C	47-51
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	167-170	kexin KEX2	Saccharomyces cerevisiae S288C	104-108
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	177-180	kexin KEX2	Saccharomyces cerevisiae S288C	104-108
20362274-4	2010	We found a disease-segregating mutation in the X-linked AIFM1 gene, encoding the Apoptosis-Inducing Factor (AIF) mitochondrion-associated 1 precursor that deletes arginine 201 (R201 del).	Arginine	163-171	apoptosis inducing factor mitochondria associated 1	Homo sapiens	56-61
1587790-1	1992	We have recently shown that furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, is involved in precursor cleavage at sites marked by the Arg-X-Lys/Arg-Arg motif within the constitutive secretory pathway.	Arginine	177-180	kexin KEX2	Saccharomyces cerevisiae S288C	104-108
1371469-3	1992	Activation of these autoreactive cells requires the use of the vitronection receptor (VNR) as an accessory molecule which interacts with the Arg-Gly-Asp-Ser (RGDS) sequence of extracellular matrix (ECM) proteins.	Arginine	141-144	ral guanine nucleotide dissociation stimulator	Mus musculus	158-162
20362274-4	2010	We found a disease-segregating mutation in the X-linked AIFM1 gene, encoding the Apoptosis-Inducing Factor (AIF) mitochondrion-associated 1 precursor that deletes arginine 201 (R201 del).	Arginine	163-171	apoptosis inducing factor mitochondria associated 1	Homo sapiens	81-106
20362274-4	2010	We found a disease-segregating mutation in the X-linked AIFM1 gene, encoding the Apoptosis-Inducing Factor (AIF) mitochondrion-associated 1 precursor that deletes arginine 201 (R201 del).	Arginine	163-171	apoptosis inducing factor mitochondria associated 1	Homo sapiens	56-59
1573281-1	1992	The highly conserved amino acid residues Leu-30 and Arg-33 of human interferon-alpha 4 (IFN-alpha 4) have previously been identified as important for biological activity.	Arginine	52-55	interferon alpha 4	Homo sapiens	68-86
20180640-7	2010	KLK2 proteolyzed IGFBP-3 into several small fragments, mostly after Arg residues, in keeping with the trypsin-like activity of KLK2.	Arginine	68-71	kallikrein related peptidase 2	Homo sapiens	0-4
1573281-1	1992	The highly conserved amino acid residues Leu-30 and Arg-33 of human interferon-alpha 4 (IFN-alpha 4) have previously been identified as important for biological activity.	Arginine	52-55	interferon alpha 4	Homo sapiens	88-99
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	integrin subunit alpha 2b	Homo sapiens	4-10
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	vitronectin	Homo sapiens	292-303
1323869-3	1992	The GP IIb/IIIa complex is an adhesion receptor belonging to the integrin superfamily; it can bind five adhesive proteins containing the arginine-glycine-aspartic acid (RGD) sequence in their structure: fibrinogen (Fg), von Willebrand factor (vWf), thrombospondin (Tsp), fibronectin (Fn) and vitronectin (Vn).	Arginine	137-145	vitronectin	Homo sapiens	305-307
20140625-8	2010	CONCLUSION: In our study, the 399-Gln allele of XRCC1 increased significantly the risk of BC and it may act as a dominant allele [Arg/Arg vs. (Gln/Gln + Arg/Gln), OR = 4.67 (95% CI 1.65-13.23), p = 0.005].	Arginine	130-133	X-ray repair cross complementing 1	Homo sapiens	48-53
20140625-8	2010	CONCLUSION: In our study, the 399-Gln allele of XRCC1 increased significantly the risk of BC and it may act as a dominant allele [Arg/Arg vs. (Gln/Gln + Arg/Gln), OR = 4.67 (95% CI 1.65-13.23), p = 0.005].	Arginine	134-137	X-ray repair cross complementing 1	Homo sapiens	48-53
20140625-8	2010	CONCLUSION: In our study, the 399-Gln allele of XRCC1 increased significantly the risk of BC and it may act as a dominant allele [Arg/Arg vs. (Gln/Gln + Arg/Gln), OR = 4.67 (95% CI 1.65-13.23), p = 0.005].	Arginine	134-137	X-ray repair cross complementing 1	Homo sapiens	48-53
20376790-6	2010	RESULTS: A heterozygous nonsense mutation at codon 564 of the SCNN1B gene from CGA(Arg) to stop codon(TGA) was detector in the proband of family 1.	Arginine	83-86	sodium channel epithelial 1 subunit beta	Homo sapiens	62-68
1415362-7	1992	Reprocessing reduced the significant generation of C3a des Arg observed with new CA and PMMA membranes.	Arginine	59-62	complement C3	Homo sapiens	51-54
20097867-12	2010	These studies implicate Arg2 in the immune evasion of H. pylori by causing intracellular depletion of l-arginine and thus reduction of NO-dependent bactericidal activity.	Arginine	102-112	arginase type II	Mus musculus	24-28
1717468-0	1991	Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligand.	Arginine	0-8	integrin subunit alpha V	Homo sapiens	82-105
19899168-6	2010	The transmembrane (TM) 1 arginine-TM 10 aspartate strut formed less readily in DAT compared with LeuT, with or without substrate present.	Arginine	25-33	solute carrier family 6 member 3	Homo sapiens	79-82
1937055-5	1991	The role of the KEX2 protease cleavage site was investigated by mutation of the yeast alpha-factor KEX2 site (cleavage after Lys-Arg).	Arginine	129-132	kexin KEX2	Saccharomyces cerevisiae S288C	99-103
20064935-4	2010	We found that the conserved putative nuclear localization sequence Arg-Lys-Arg-Arg, which is retained in a highly aggregation-prone fragment of ataxin-3, did not affect the site and degree of inclusion formation in a cell culture model of spinocerebellar ataxia type 3.	Arginine	67-70	ataxin 3	Homo sapiens	144-152
1821811-2	1991	BPTI is fused through an FXa (blood coagulation factor Xa protease) target sequence (Ile-Glu-Gly-Arg) to the C-terminus of MBP.	Arginine	97-100	spleen trypsin inhibitor I	Bos taurus	0-4
1821811-4	1991	Effective FXa cleavage is achieved by spacing the FXa target sequence and Arg-1 of the BPTI sequence with four residues (Met-Glu-Ala-Glu).	Arginine	74-77	spleen trypsin inhibitor I	Bos taurus	87-91
20133688-2	2010	The NFAT-interacting protein, (NIP45), augments NFAT-driven IL-4 expression by a mechanism that relies on arginine methylation.	Arginine	106-114	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein	Mus musculus	31-36
20133688-5	2010	Whereas NIP45 deficiency does not interfere with T helper cell NFAT activation or lineage-specific transcription-factor expression, NIP45 acts as an enhancer for the assembly of protein arginine methyltransferase 1 and the protein arginine methyltransferase 1-linked histone 4 arginine 3 methylation with the IL-4 promoter.	Arginine	186-194	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein	Mus musculus	132-137
20159462-4	2010	Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini.	Arginine	121-130	BRCA1 DNA repair associated	Homo sapiens	22-27
1910042-2	1991	Eleven amino acid substitutions at Val-121 of human carbonic anhydrase II including Gly, Ala, Ser, Leu, Ile, Lys, and Arg, were constructed by site-directed mutagenesis.	Arginine	118-121	carbonic anhydrase 2	Homo sapiens	52-73
20159462-4	2010	Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini.	Arginine	121-130	mediator of DNA damage checkpoint 1	Homo sapiens	32-36
20159462-4	2010	Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini.	Arginine	121-130	BRCA1 DNA repair associated	Homo sapiens	143-148
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Arginine	162-165	phospholipase A2 activating protein	Homo sapiens	73-111
20159462-4	2010	Crystal structures of BRCA1 and MDC1 bound to tetrapeptide substrates reveal differences in the environment of conserved arginines (Arg1699 in BRCA1 and Arg1933 in MDC1) that determine the relative affinity for peptides with -COO(-) versus -CO-NH(2) termini.	Arginine	121-130	mediator of DNA damage checkpoint 1	Homo sapiens	164-168
1958054-3	1991	The active form is generated upon proteolytic cleavage of the N-terminal prophospholipase A2 activation peptide (PLAP), with the sequence Asp-Ser-Gly-Ile-Ser-Pro-Arg (DSGISPR).	Arginine	162-165	phospholipase A2 activating protein	Homo sapiens	113-117
20110615-0	2010	Tau phosphorylated at tyrosine 394 is found in Alzheimer"s disease tangles and can be a product of the Abl-related kinase, Arg.	Arginine	123-126	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-106
20110615-8	2010	We report, for the first time, that Arg, the other member of the Abl family of tyrosine kinases, also phosphorylates tau at Y394 in a manner independent of Abl activity.	Arginine	36-39	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	65-68
20016065-5	2010	Protein interactions were also detected between RBMY and splicing factors 9G8 and transformer-2 protein homolog beta (Tra2-beta), mediated by multiple regions of the RBMY protein that contain serine/arginine-rich dipeptides, but not by the single region lacking such dipeptides.	Arginine	199-207	RNA binding motif protein Y-linked family 1 member A1	Homo sapiens	48-52
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Arginine	207-210	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1761369-8	1991	The preferential stability of fos-jun heterodimer over the jun-jun and fos-fos homodimers is primarily due to the side chains Asp b1, Glu g1, Asp b2, Glu e2, Glu g2, Glu g3, and Lys a5 of the fos helix, and Arg c1, Lys g1, Lys b2, Lys e2, Arg e4, and Glu g4 of the jun helix.	Arginine	239-242	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	30-33
1714727-0	1991	Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages.	Arginine	161-169	calmodulin 2	Mus musculus	121-131
20016065-5	2010	Protein interactions were also detected between RBMY and splicing factors 9G8 and transformer-2 protein homolog beta (Tra2-beta), mediated by multiple regions of the RBMY protein that contain serine/arginine-rich dipeptides, but not by the single region lacking such dipeptides.	Arginine	199-207	transformer 2 beta homolog	Homo sapiens	66-116
20016065-5	2010	Protein interactions were also detected between RBMY and splicing factors 9G8 and transformer-2 protein homolog beta (Tra2-beta), mediated by multiple regions of the RBMY protein that contain serine/arginine-rich dipeptides, but not by the single region lacking such dipeptides.	Arginine	199-207	transformer 2 beta homolog	Homo sapiens	118-127
20016065-5	2010	Protein interactions were also detected between RBMY and splicing factors 9G8 and transformer-2 protein homolog beta (Tra2-beta), mediated by multiple regions of the RBMY protein that contain serine/arginine-rich dipeptides, but not by the single region lacking such dipeptides.	Arginine	199-207	RNA binding motif protein Y-linked family 1 member A1	Homo sapiens	166-170
20303810-2	2010	The enzyme that produces NAG from glutamate and CoA, NAG synthase (NAGS), is allosterically inhibited by arginine in microorganisms and plants and activated in mammals.	Arginine	105-113	N-acetylglutamate synthase	Homo sapiens	53-65
20303810-2	2010	The enzyme that produces NAG from glutamate and CoA, NAG synthase (NAGS), is allosterically inhibited by arginine in microorganisms and plants and activated in mammals.	Arginine	105-113	N-acetylglutamate synthase	Homo sapiens	67-71
1907272-1	1991	The Arg-Gly-Asp (RGD)-binding domain of GPIIb-IIIa has been localized in a fragment of the GPIIIa subunit that includes the sequence between amino acids 109 and 171.	Arginine	4-7	integrin subunit alpha 2b	Homo sapiens	40-45
20303810-5	2010	Almost all NAGS genes possess a C-terminus transferase domain in which the catalytic activity resides and an N-terminus kinase domain where arginine binds.	Arginine	140-148	N-acetylglutamate synthase	Homo sapiens	11-15
19882657-0	2010	Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.	Arginine	113-116	integrin subunit alpha V	Homo sapiens	28-51
19882657-0	2010	Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin.	Arginine	113-116	vitronectin	Homo sapiens	52-63
1659747-9	1991	In the third experiment the RGDS peptide (ARG-GLY-ASP-SER), a blocker of GPIIb/IIIa platelet receptor dose dependently inhibited platelet aggregation by 93 +/- 17%.	Arginine	42-45	integrin subunit alpha 2b	Homo sapiens	73-78
19882657-4	2010	The Arg-Gly-Asp (RGD)-binding site recognition by P11 was site specific because the P11 was inactive for the complex formation of a denatured form of integrin-vitronectin.	Arginine	4-7	vitronectin	Homo sapiens	159-170
19719118-1	2009	Integrin alpha(v)beta(3) plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence.	Arginine	145-153	integrin subunit alpha V	Homo sapiens	0-24
1855257-3	1991	ASF-1 consists of 248 amino acid residues, including an 80 residue RNA-binding domain at its N-terminus and a 50 residue C-terminal region that is 80% serine plus arginine.	Arginine	163-171	serine and arginine rich splicing factor 1	Homo sapiens	0-3
19880550-2	2009	Two polymorphisms of XRCC1, rs1799782 (Arg &gt; Trp at codon 194) and rs25487 (Arg &gt; Gln at codon 399), are common in the Han Chinese population.	Arginine	39-42	X-ray repair cross complementing 1	Homo sapiens	21-26
1650206-0	1991	Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an L-arginine-dependent process.	Arginine	85-95	histamine H1 receptor	Cavia porcellus	0-21
1829526-3	1991	Its binding to FN was inhibited by anti-FN antibody or a mixture of synthetic peptides corresponding to two different sites of FN, termed the V10 sequence and the RGDS (Arg-Gly-Asp-Ser) sequence, which interact, respectively, with the VLA-4 and VLA-5 FN receptors expressed on T-lineage cells.	Arginine	169-172	ral guanine nucleotide dissociation stimulator	Mus musculus	163-167
19717558-8	2009	However, charge reversal arginine substitutions strongly reduced the current density of these homotetrameric mutant Kv2.1 channels and immunocytochemistry confirmed the reduced expression at the plasma membrane.	Arginine	25-33	potassium voltage-gated channel subfamily B member 1	Homo sapiens	116-121
1829159-7	1991	One of the characteristic features of the rep gene is frequent usage of rare codons, especially those for arginine.	Arginine	106-114	replication protein	Escherichia coli	42-45
19717558-11	2009	The corresponding arginine substitution in Kv6.4 prevented its heterotetrameric interaction with Kv2.1.	Arginine	18-26	potassium voltage-gated channel subfamily B member 1	Homo sapiens	97-102
1674745-6	1991	A C to T mutation converted arginine (CGT) at position 145 of the mature protein to cysteine (TGT) thus creating the apoE-2 variant.	Arginine	28-36	UDP glycosyltransferase 8	Homo sapiens	38-41
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Arginine	244-247	fibronectin 1a	Danio rerio	50-63
2053593-11	1991	Introduction of higher levels of HC3a or HC3ades Arg (2.5 to 5.0 x 10(-6) mol/l) to the peritoneal cavity of the rat stimulated both chymase release and HC3a degradation without other mast cell activators being present.	Arginine	49-52	chymase 1	Rattus norvegicus	133-140
2053593-13	1991	It was concluded that the mechanism of RMC activation by C3a (C3ades Arg) was nonspecific and similar to the process by which polyamines and polycations stimulate mast cells, as C3a is a highly cationic molecule.	Arginine	69-72	complement C3	Homo sapiens	57-60
2053593-13	1991	It was concluded that the mechanism of RMC activation by C3a (C3ades Arg) was nonspecific and similar to the process by which polyamines and polycations stimulate mast cells, as C3a is a highly cationic molecule.	Arginine	69-72	complement C3	Homo sapiens	62-65
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Arginine	244-247	fibronectin 1a	Danio rerio	50-61
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Arginine	306-309	fibronectin 1a	Danio rerio	50-63
1716435-8	1991	It may be significant that, for both DR2 and DR4, only the more protective subtypes have arginine at amino acid position 71.	Arginine	89-97	major histocompatibility complex, class II, DR beta 4	Homo sapiens	45-48
1711024-11	1991	This protein is highly homologous with the AroP (general aromatic transport) system of E. coli (59.6% identity) and to a lesser extent with the yeast permeases CAN1 (arginine), PUT4 (proline), and HIP1 (histidine) of Saccharomyces cerevisiae.	Arginine	166-174	arginine permease CAN1	Saccharomyces cerevisiae S288C	160-164
19747169-5	2009	Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin.	Arginine	306-309	fibronectin 1a	Danio rerio	50-61
19679652-6	2009	We also demonstrate that GNF-2 can inhibit enzymatic and cellular kinase activity of Arg, a kinase highly homologous to c-Abl, which is also likely to be regulated through intramolecular binding of an NH(2)-terminal myristate lipid.	Arginine	85-88	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	120-125
19631611-3	2009	Furthermore, metabolites such as arginine, glutamate, citrate, and oxalacetate also exerted a negative effect on the PII-NAGK complex formation in the presence of Mg-ATP.	Arginine	33-41	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	121-125
1895885-6	1991	Amino acid analyses of the aortic tissue elastin revealed that the proline levels in the triol-fed animals were significantly greater than in the other two diet groups, while the elastin levels of leucine, aspartate, arginine, and phenylalanine decreased significantly.	Arginine	217-225	elastin	Rattus norvegicus	179-186
1846968-4	1991	Human fibrillarin contains an amino-terminal repetitive domain approximately 75-80 amino acids in length that is rich in glycine and arginine residues and is similar to amino-terminal domains in the yeast and Xenopus fibrillarins.	Arginine	133-141	fibrillarin	Homo sapiens	6-17
19562367-6	2009	Lastly, silencing of SLC7A6, the gene for y(+)LAT2, lowers arginine transport and doubles the intracellular content of the cationic amino acid in K562 cells.	Arginine	59-67	solute carrier family 7 member 6	Homo sapiens	21-27
19562367-6	2009	Lastly, silencing of SLC7A6, the gene for y(+)LAT2, lowers arginine transport and doubles the intracellular content of the cationic amino acid in K562 cells.	Arginine	59-67	solute carrier family 7 member 6	Homo sapiens	42-50
19562367-7	2009	We conclude that arginine transport in human erythroid cells is due to both system y(+) (CAT1 transporter) and system y(+)L (4F2hc/y(+)LAT2 isoform), which mainly contribute, respectively, to the influx and to the efflux of the cationic amino acid.	Arginine	17-25	transient receptor potential cation channel subfamily V member 6	Homo sapiens	89-93
19562367-7	2009	We conclude that arginine transport in human erythroid cells is due to both system y(+) (CAT1 transporter) and system y(+)L (4F2hc/y(+)LAT2 isoform), which mainly contribute, respectively, to the influx and to the efflux of the cationic amino acid.	Arginine	17-25	solute carrier family 7 member 6	Homo sapiens	131-139
20641937-2	2004	Bombesin (BN) is an amphibian neuropeptide consisting of 14 amino acids (pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) (2, 3), first isolated from frog skin in 1970 (4).	Arginine	82-85	gastrin releasing peptide	Homo sapiens	0-8
1846292-9	1991	Both IGF I receptor dimers and tetramers exhibit similar kinase activities using the synthetic substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, indicating that the failure to detect autophosphorylation of the IGF I receptor dimers does not result from inactivation of the kinase by DTT treatment.	Arginine	109-112	insulin like growth factor 1 receptor	Homo sapiens	5-19
19707686-1	2009	Previously, downsizing of a 14-residue peptidic CXCR4 antagonist has led to the development of a highly potent CXCR4 antagonist [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)].	Arginine	145-148	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
1988109-7	1991	NO2-/NO3- levels may signify nitric oxide production as a result of stimulation of the L-arginine-dependent pathway in activated macrophages.	Arginine	87-97	NBL1, DAN family BMP antagonist	Mus musculus	0-8
19707686-1	2009	Previously, downsizing of a 14-residue peptidic CXCR4 antagonist has led to the development of a highly potent CXCR4 antagonist [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)].	Arginine	145-148	C-X-C motif chemokine receptor 4	Homo sapiens	111-116
19707686-1	2009	Previously, downsizing of a 14-residue peptidic CXCR4 antagonist has led to the development of a highly potent CXCR4 antagonist [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)].	Arginine	152-155	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
19707686-1	2009	Previously, downsizing of a 14-residue peptidic CXCR4 antagonist has led to the development of a highly potent CXCR4 antagonist [cyclo(-d-Tyr(1)-Arg(2)-Arg(3)-Nal(4)-Gly(5)-)].	Arginine	152-155	C-X-C motif chemokine receptor 4	Homo sapiens	111-116
19707686-2	2009	In the present study, cyclic pentapeptide libraries that were designed by substitutions of several amino acids for d-Tyr(1) and Arg(2) in peptide were prepared and screened to evaluate binding activity for CXCR4.	Arginine	128-131	C-X-C motif chemokine receptor 4	Homo sapiens	206-211
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	38-46	N-acetyltransferase 2	Homo sapiens	108-112
2128973-0	1990	Fibrin specific thrombolysis by two-chain urokinase-type plasminogen activator cleaved after arginine 156 by thrombin.	Arginine	93-101	prothrombin	Oryctolagus cuniculus	109-117
2128973-1	1990	Scu-PA was cleaved by thrombin after arginine-156 to yield a two-chain molecule with low amidolytic activity and resistance to cleavage by plasmin.	Arginine	37-45	prothrombin	Oryctolagus cuniculus	22-30
2206132-3	1990	H-7, a specific inhibitor of protein kinase C (PKC), significantly inhibited these effects of arginine.	Arginine	94-102	solute carrier family 9 member A2	Rattus norvegicus	0-3
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	38-46	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	38-46	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	38-46	N-acetyltransferase 2	Homo sapiens	119-123
2126205-3	1990	The protein is a parvalbumin consisting of 108 residues with a blocked amino terminus, a single cysteine, tyrosine, proline and arginine and no histidine, methionine or tryptophan.	Arginine	128-136	parvalbumin	Gallus gallus	17-28
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	48-51	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	48-51	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	48-51	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	48-51	N-acetyltransferase 2	Homo sapiens	119-123
19360404-1	2009	PURPOSE: Radiolabeled Arg-Gly-Asp (RGD) and bombesin (BBN) peptide analogs have been extensively investigated for the imaging of tumor integrin alpha(v)beta(3) and gastrin-releasing peptide receptor (GRPR) expression, respectively.	Arginine	22-25	integrin subunit alpha V	Homo sapiens	135-159
1704611-1	1990	Human atrial natriuretic peptide [ANF(1-28)] contains five arginine residues and carries an overall positive change of four.	Arginine	59-67	natriuretic peptide A	Rattus norvegicus	6-32
19664060-0	2009	Inactivating pentapeptide insertions in the fission yeast replication factor C subunit Rfc2 cluster near the ATP-binding site and arginine finger motif.	Arginine	130-138	replication factor C subunit 2	Saccharomyces cerevisiae S288C	87-91
2235124-1	1990	Circulating arginine available for synthesis of protein is produced in the kidney of the adult mammal by the action of the last two enzymes of the urea cycle, argininosuccinate synthase and argininosuccinate lyase.	Arginine	12-20	argininosuccinate lyase	Homo sapiens	190-213
2235124-7	1990	Ornithine decarboxylase activity was undetectable in the intestine of the mouse during the suckling period and was detected briefly at weaning, indicating that ornithine synthesized in the intestinal mitochondria is probably not diverted actively into the polyamine pathway and is available for synthesis of arginine by the enzymes of the urea cycle.	Arginine	308-316	ornithine decarboxylase, structural 1	Mus musculus	0-23
19544227-1	2009	A common genetic variation in the alpha-actinin-3 ( ACTN3) gene causes a replacement of an arginine (R) with a premature stop codon (X) at amino-acid 577 (rs1815739).	Arginine	91-99	actinin alpha 3	Homo sapiens	34-49
2169933-0	1990	Measurement of (C13)arginine incorporation into apolipoprotein B-100 in very low density lipoproteins and low density lipoproteins in normal subjects using (13C)sodium bicarbonate infusion and isotope ratio mass spectrometry.	Arginine	20-28	homeobox C13	Homo sapiens	16-19
19544227-1	2009	A common genetic variation in the alpha-actinin-3 ( ACTN3) gene causes a replacement of an arginine (R) with a premature stop codon (X) at amino-acid 577 (rs1815739).	Arginine	91-99	actinin alpha 3	Homo sapiens	52-57
2201025-2	1990	Microsequencing showed that HIV-1 PR cleaved both human and murine vimentin between leucine-422 and arginine-423 within the sequence between positions 418 and 427, Ser-Ser-Leu-Asn-Leu/Arg-Glu-Thr-Asn-Leu (SSLNL/RETNL).	Arginine	100-108	vimentin	Mus musculus	67-75
2201025-2	1990	Microsequencing showed that HIV-1 PR cleaved both human and murine vimentin between leucine-422 and arginine-423 within the sequence between positions 418 and 427, Ser-Ser-Leu-Asn-Leu/Arg-Glu-Thr-Asn-Leu (SSLNL/RETNL).	Arginine	184-187	vimentin	Mus musculus	67-75
19596784-2	2009	TRF2 contains an N-terminal basic domain rich in glycines and arginines, similar to the GAR motif that is methylated by protein arginine methyltransferases.	Arginine	62-71	telomeric repeat binding factor 2	Homo sapiens	0-4
2196279-4	1990	By directly sequencing genomic DNA amplified by polymerase chain reaction, we have demonstrated that both patients are heterozygous for the same point mutation converting codon 65 from an arginine (CGT) to a histidine (CAT) codon.	Arginine	188-196	UDP glycosyltransferase 8	Homo sapiens	198-201
2196279-8	1990	This observation is consistent with the hypothesis that the dinucleotide sequence CpG, the first two nucleotides in the arginine (CGT) codon, is a "hot spot" for mutations.	Arginine	120-128	UDP glycosyltransferase 8	Homo sapiens	130-133
19596784-3	2009	However, whether arginine methylation regulates TRF2 function has not been determined.	Arginine	17-25	telomeric repeat binding factor 2	Homo sapiens	48-52
2370855-11	1990	The enzyme(s) showed very little activity in the presence of L-arginine (100 microM) and NADPH (100 microM), but the activity could be fully restored by addition of exogenous calmodulin (EC50, approximately 2 units/ml).	Arginine	61-71	calmodulin 2	Mus musculus	175-185
19596784-4	2009	Here we report that amino acid substitutions of arginines with lysines in the basic domain of TRF2 induce telomere dysfunction-induced focus formation, leading to induction of cellular senescence.	Arginine	48-57	telomeric repeat binding factor 2	Homo sapiens	94-98
19596784-6	2009	We uncovered that TRF2 interacts with PRMT1, and its arginines in the basic domain undergo PRMT1-mediated methylation both in vitro and in vivo.	Arginine	53-62	telomeric repeat binding factor 2	Homo sapiens	18-22
19596784-6	2009	We uncovered that TRF2 interacts with PRMT1, and its arginines in the basic domain undergo PRMT1-mediated methylation both in vitro and in vivo.	Arginine	53-62	protein arginine methyltransferase 1	Homo sapiens	91-96
2160459-9	1990	Identification of POMC-derived peptides demonstrated efficient processing of Lys-Arg and inefficient processing of Lys-Lys and Arg-Lys sites at both positions in the prohormone.	Arginine	81-84	proopiomelanocortin	Rattus norvegicus	18-22
19653625-8	2009	In the modeled three-dimensional structure of AtPCS1, Arg 183 is within close proximity to Thr 49.	Arginine	54-57	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	46-52
1692034-3	1990	Recent cDNA cloning reveals that like other adhesive proteins, Vn contains the sequence Arg-Gly-Asp and binds to some members of the integrin class of adhesive membrane receptors.	Arginine	88-91	vitronectin	Homo sapiens	63-65
2328319-10	1990	We found a G to A base substitution in the 22nd codon (CAT for CGT), which changes the normal arginine to a histidine.	Arginine	94-102	UDP glycosyltransferase 8	Homo sapiens	63-66
2322283-1	1990	The arginine located at position 44 of mouse thymidylate synthase is in a highly conserved loop that is in close proximity to the active site cleft of the enzyme.	Arginine	4-12	thymidylate synthase	Mus musculus	45-65
2313096-3	1990	Gc-Globulin (GcG) can function as a cochemotaxin for C5a by binding to C5a or C5a des Arg and enhancing its chemotactic potency.	Arginine	86-89	GC vitamin D binding protein	Homo sapiens	0-11
2313096-3	1990	Gc-Globulin (GcG) can function as a cochemotaxin for C5a by binding to C5a or C5a des Arg and enhancing its chemotactic potency.	Arginine	86-89	GC vitamin D binding protein	Homo sapiens	13-16
2313096-13	1990	Furthermore, the direct interaction of CFI with C5a and C5a des Arg was assessed by ELISA tests and column chromatography and no interaction was observed.	Arginine	64-67	complement factor I	Homo sapiens	39-42
1715119-7	1990	In spite of the cross-reactivity for binding to vWF, only the two antibodies whose epitopes included residues in the Arg-Gly-Asp sequence inhibited vWF interaction with GP IIb-IIIa.	Arginine	117-120	integrin subunit alpha 2b	Homo sapiens	169-175
2179200-4	1990	In the first, in which the principal protein bands (in the 34.8 to 41.3 kD range) were excluded, the 37 Group EF-4 strains formed, at the 62% S level, two major clusters corresponding to strains producing a dihydrolase for arginine and those not doing so.	Arginine	223-231	GTP binding elongation factor GUF1	Homo sapiens	110-114
11413375-3	2001	Recently, catalytically inactive NS3 fragments containing an arginine-rich motif have been reported to interact with, and inhibit, the catalytic subunit of cAMP-dependent protein kinase (PKA C-subunit).	Arginine	61-69	KRAS proto-oncogene, GTPase	Homo sapiens	33-36
11413375-5	2001	This inhibition was abrogated by mutation of either the arginine-rich motif or the conserved helicase motif II, both of which also abolished NTPase activity.	Arginine	56-64	inosine triphosphatase	Homo sapiens	141-147
11413375-9	2001	Our data are thus not consistent with the previously proposed model in which the arginine-rich motif of NS3 was suggested to act as a pseudosubstrate inhibitor of PKA C-subunit.	Arginine	81-89	KRAS proto-oncogene, GTPase	Homo sapiens	104-107
1531632-1	1992	Among the few proteins of the eukaryotic nucleolus that have been characterized, four proteins, nucleolin, fibrillarin, SSB1 and NSR1, possess a common structural motif, the GAR domain, which is rich in glycine and arginine residues.	Arginine	215-223	Hsp70 family ATPase SSB1	Saccharomyces cerevisiae S288C	120-124
1531632-1	1992	Among the few proteins of the eukaryotic nucleolus that have been characterized, four proteins, nucleolin, fibrillarin, SSB1 and NSR1, possess a common structural motif, the GAR domain, which is rich in glycine and arginine residues.	Arginine	215-223	Nsr1p	Saccharomyces cerevisiae S288C	129-133
34647407-5	2022	VEGF-B - derived peptides containing a C-terminal arginine show potent binding to NRP1-b1.	Arginine	50-58	vascular endothelial growth factor B	Homo sapiens	0-6
34647407-7	2022	A crystal structure of a peptide with NRP-1 demonstrated that VEGF-B peptides bind at the canonical C-terminal Arginine binding site.	Arginine	111-119	vascular endothelial growth factor B	Homo sapiens	62-68
34627965-8	2022	Null model analysis showed that ARG assembly in the Yellow River was more influenced by stochastic processes than tap water and this was independent of seasons.	Arginine	32-35	nuclear RNA export factor 1	Homo sapiens	114-117
34841440-7	2022	The expression levels of SNHG1 in cardiomyocytes treated with H/R were detected using reverse transcription-quantitative PCR.	Arginine	64-65	small nucleolar RNA host gene 1	Homo sapiens	25-30
34841440-15	2022	To conclude, the present study revealed the protective effect of the SNHG1/miR-16-5p/GATA4 positive feedback loop on cardiomyocyte injury induced by H/R and provided a potential therapeutic target for ischemic cardiomyocyte injury.	Arginine	151-152	small nucleolar RNA host gene 1	Homo sapiens	69-74
34841440-15	2022	To conclude, the present study revealed the protective effect of the SNHG1/miR-16-5p/GATA4 positive feedback loop on cardiomyocyte injury induced by H/R and provided a potential therapeutic target for ischemic cardiomyocyte injury.	Arginine	151-152	GATA binding protein 4	Homo sapiens	85-90
34569136-8	2021	These findings provide new insights both into the mechanism of crosstalk between arginine methylation and lysine acetylation and inform the design of potent peptidomimetic CARM1 inhibitors.	Arginine	81-89	coactivator associated arginine methyltransferase 1	Homo sapiens	172-177
34943060-10	2021	Our findings revealed that l-Arg could be used as a potential nutraceutical in reducing muscle injury via regulating SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways.	Arginine	27-32	forkhead box O3	Mus musculus	142-148
34738042-7	2021	Relative mRNA expression levels of Ca2+ channels including the type 1 ryanodine receptor (RyR1) and voltage-gated Ca2+ channel (Cav1.1) were upregulated by 1.2 mmol/L arginine during 2-d myogenic induction (P < 0.01).	Arginine	167-175	calcium channel, voltage-dependent, L type, alpha 1S subunit	Mus musculus	128-134
34867480-1	2021	The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells (PTC) and upregulated by renal ischemia.	Arginine	85-95	arginase type II	Mus musculus	19-35
34833139-1	2021	PRMT2 belongs to the protein arginine methyltransferase (PRMT) family, which catalyzes the arginine methylation of target proteins.	Arginine	91-99	protein arginine methyltransferase 2	Homo sapiens	0-5
19653625-10	2009	This result suggested that Arg 183 may play an important role in the catalytic mechanism of AtPCS1.	Arginine	27-30	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	92-98
19577562-1	2009	The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929-933 sequence of beta1 chain, is known to inhibit tumor growth and metastasis.	Arginine	47-55	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	114-119
19404000-4	2009	On the other hand, PGF stimulated the expression of inducible NOS (iNOS) mRNA (P&lt;0.05) and protein (P&lt;0.05) at 2 h, but not at 6 and 24 h. By observing the conversion of [(3)C](L)-arginine to [(3)C](L)-citrulline, we found that PGF stimulated NOS activity in cultured LECs at 2 h (P&lt;0.05).	Arginine	184-194	nitric oxide synthase 2	Bos taurus	52-65
19427250-4	2009	A single C-T base change was introduced into exon 6 of the human MUT sequence in the BAC clone RP11-463L20 resulting in an arginine residue being replaced with a TGA stop codon.	Arginine	123-131	pre-mRNA processing factor 31	Homo sapiens	95-99
19641117-4	2009	The ability of cAMP to overcome inhibition by MAG in culture involves the upregulation of the enzyme arginase I (Arg I) and subsequent increase in synthesis of polyamines such as putrescine.	Arginine	113-116	myelin associated glycoprotein	Homo sapiens	46-49
19420114-11	2009	In conclusion, attenuated glomerular arginine transport by CAT-1 contributes to the age-dependent, NO-deficient state in old male rats through upregulation of PKCalpha.	Arginine	37-45	protein kinase C, alpha	Rattus norvegicus	159-167
19420114-12	2009	In old females glomerular arginine transport is protected from the effects of PKCalpha by an unknown mechanism.	Arginine	26-34	protein kinase C, alpha	Rattus norvegicus	78-86
19173225-1	2009	L-citrulline, L-ornithine, and agmatine are the metabolites of L-arginine by nitric oxide synthase (NOS), arginase, and arginine decarboxylase (ADC), respectively.	Arginine	63-73	antizyme inhibitor 2	Rattus norvegicus	120-142
19173225-1	2009	L-citrulline, L-ornithine, and agmatine are the metabolites of L-arginine by nitric oxide synthase (NOS), arginase, and arginine decarboxylase (ADC), respectively.	Arginine	63-73	antizyme inhibitor 2	Rattus norvegicus	144-147
19401151-2	2009	sL1 is a ligand for several Arg-Gly-Asp (RGD)-binding integrins and can be deposited in the extracellular matrix.	Arginine	28-31	TATA-box binding protein associated factor, RNA polymerase I subunit A	Homo sapiens	0-3
19401154-4	2009	FhcatB1 has biochemical properties distinct from mammalian cathepsin B enzymes, with an atypical preference for Ile over Leu or Arg residues at the P(2) substrate position and an inability to act as an exopeptidase.	Arginine	128-131	cathepsin B	Homo sapiens	59-70
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Arginine	78-81	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
19638477-3	2009	Based on a published high-resolution (2.89 A) tubulin structure, we predict that Arg-2 of alpha-tubulin forms hydrogen bonds with the GTPase domain of beta-tubulin, and structural modeling suggests that these contacts are interrupted in tor2.	Arginine	81-84	tubulin alpha-5	Arabidopsis thaliana	90-103
19519483-4	2009	DARC is an unorthodox chemokine receptor as (i) it binds chemokines of both CC and CXC classes and (ii) it lacks the Asp-Arg-Tyr consensus motif in its second cytoplasmic loop hence cannot couple to G proteins and activate their signaling pathways.	Arginine	121-124	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	0-4
19289494-8	2009	Our findings also suggest that arginine methylation by PRMT1 is a key posttranslational modification in the DNA damage response pathway in proliferating mammalian cells.	Arginine	31-39	protein arginine methyltransferase 1	Homo sapiens	55-60
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	caspase 1	Rattus norvegicus	122-138
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	188-197
19212806-8	2009	In contrast, Arg supplementation reduced mRNA levels for fatty acid binding protein 1, glycogenin, protein phosphates 1B, caspases 1 and 2, and hepatic lipase, but increased expression of PPARgamma, heme oxygenase 3, glutathione synthetase, insulin-like growth factor II, sphingosine-1-phosphate receptor, and stress-induced protein.	Arginine	13-16	insulin-like growth factor 2	Rattus norvegicus	241-270
34816043-10	2021	The SRP and Arg groups demonstrated nonsignificantly increased density of CD68+ and CD163 + cells.	Arginine	12-15	CD68 molecule	Homo sapiens	74-78
19274602-3	2009	A cohort of 546 French vinyl chloride workers were genotyped for the XRCC1 codon 194 (Arg&gt;Trp; rs1799782), 280 (Arg&gt;His; rs25489) and 399 (Arg&gt;Gln; rs25487) polymorphisms and the ERCC2/XPD codon 312 (Asp&gt;Asn; rs1799793) and 751 (Lys&gt;Gln; rs13181) polymorphisms.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	69-74
34816043-10	2021	The SRP and Arg groups demonstrated nonsignificantly increased density of CD68+ and CD163 + cells.	Arginine	12-15	CD163 molecule	Homo sapiens	84-89
18992360-4	2009	Mutagenesis of three sites containing basic residues within the ADAMTS5 propeptide (RRR(46), RRR(69) and RRRRR(261)) suggested that proADAMTS5 processing occurs after Arg(261).	Arginine	167-170	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	64-71
34418357-1	2021	The enzymes glycine amidinotransferase, mitochondrial (GATM also known as AGAT) and guanidinoacetate N-methyltransferase (GAMT) function together to synthesize creatine from arginine, glycine, and S-Adenosyl methionine.	Arginine	174-182	glycine amidinotransferase	Homo sapiens	55-59
34418357-1	2021	The enzymes glycine amidinotransferase, mitochondrial (GATM also known as AGAT) and guanidinoacetate N-methyltransferase (GAMT) function together to synthesize creatine from arginine, glycine, and S-Adenosyl methionine.	Arginine	174-182	glycine amidinotransferase	Homo sapiens	74-78
19188198-4	2009	This results in a change of the initiation codon in ATPase 6 to threonine and a concurrent change from a highly conserved hydrophobic amino acid, tryptophan, at position 55 of ATPase 8 to a highly basic arginine.	Arginine	203-211	mitochondrially encoded ATP synthase 8	Homo sapiens	176-184
34671164-10	2021	ADP-riboxanation of the arginine blocked autoprocessing of caspase-4/11 as well as their recognition and cleavage of GSDMD.	Arginine	24-32	gasdermin D	Mus musculus	117-122
19259068-2	2009	We have developed a peptide-like scaffold (regioselectively addressable functionalized template, RAFT), which holds four cyclo(-RGDfK-) (cRGD) motifs and proved that this molecule (called regioselectively addressable functionalized template-arginine-glycine-aspartic acid, RAFT-RGD) targets integrin alpha(v)beta(3) in vitro and in vivo.	Arginine	241-249	integrin subunit alpha V	Homo sapiens	291-314
19218244-10	2009	The proteasome inhibitor MG132 reduced CPT-induced Tra2 degradation and TAF1 alternative splicing, and mutation of evolutionarily conserved Tra2 lysine 81, a potential ubiquitin conjugation site, to arginine inhibited CPT-induced Tra2 degradation, supporting a proteasome-dependent alternative splicing mechanism.	Arginine	199-207	transformer 2	Drosophila melanogaster	140-144
19218244-10	2009	The proteasome inhibitor MG132 reduced CPT-induced Tra2 degradation and TAF1 alternative splicing, and mutation of evolutionarily conserved Tra2 lysine 81, a potential ubiquitin conjugation site, to arginine inhibited CPT-induced Tra2 degradation, supporting a proteasome-dependent alternative splicing mechanism.	Arginine	199-207	transformer 2	Drosophila melanogaster	140-144
19236846-4	2009	Specifically, substitution of 31st Threonine to Arginine selectively abrogates the GTP-binding ability of Arl6 without affecting GDP-binding/dissociating properties.	Arginine	48-56	ADP ribosylation factor like GTPase 6	Homo sapiens	106-110
19226281-10	2009	Promoters of eNOS and HO-1 (L-arginine and haemin) ameliorated the [NO]/[ONOO(-)] ratio while their inhibitors (L-NAME or tin-protoporphyrin) showed no improvement in these ratio.	Arginine	28-38	heme oxygenase 1	Oryctolagus cuniculus	22-26
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Arginine	83-91	SUMO-targeted ubiquitin ligase complex subunit SLX5	Saccharomyces cerevisiae S288C	147-151
19139279-6	2009	In support of this idea, growth of Saccharomyces cerevisiae in the presence of the arginine analog canavanine results in increased SUMOylation and Slx5-Slx8-mediated degradation of wild-type Mot1.	Arginine	83-91	DNA-binding ATPase	Saccharomyces cerevisiae S288C	191-195
19284595-9	2009	CONCLUSION: L-Arg is the key player in the refolding of human G6PD, preventing the aggregation of folding intermediate, and NADP+ is essential for the folding intermediate to adopt native structure.	Arginine	12-17	glucose-6-phosphate dehydrogenase	Homo sapiens	62-66
18504524-0	2009	Binding specificity of the L-arginine transport systems in mouse macrophages and human cells overexpressing the cationic amino acid transporter hCAT-1.	Arginine	27-37	solute carrier family 7 member 1	Homo sapiens	144-150
18504524-8	2009	As a final conclusion, the following descriptors were found to be important generally for the cationic transporters: the van der Waals volume, hydrophobicity (log P); L-configuration; the size of the side chain; the general similarity to L-arginine; the presence of an alpha-amino group; the general basicity of the molecule; the pK(a) values of the alpha-amino group (in macrophages) or that of the side chain (in CAT-1 cells).	Arginine	238-248	solute carrier family 7 member 1	Homo sapiens	415-420
19038856-10	2009	These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival.	Arginine	163-171	solute carrier family 7 member 1	Homo sapiens	50-56
19038856-10	2009	These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival.	Arginine	163-171	solute carrier family 7 member 3	Homo sapiens	70-76
18680626-2	2009	OAT controls the interconversion of ornithine into glutamate semi-aldehyde, and is therefore involved in the metabolism of arginine and glutamine which play a major role in N homeostasis.	Arginine	123-131	ornithine aminotransferase	Mus musculus	0-3
18680626-3	2009	We hypothesised that OAT could be a limiting step in glutamine-arginine interconversion.	Arginine	63-71	ornithine aminotransferase	Mus musculus	21-24
18814047-9	2009	For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07).	Arginine	134-137	MDM2 proto-oncogene	Homo sapiens	67-71
18814047-9	2009	For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07).	Arginine	138-141	MDM2 proto-oncogene	Homo sapiens	67-71
19170758-1	2009	Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a family of protein arginine methyltransferases (PRMT), of which PRMT1 is the predominant member in human cells.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	171-176
19514640-8	2009	Linkage analysis revealed that the Arg/Gln-Ser/Ser combination of genotypes of XRCC1 and hOGG1, respectively (not associated with a decreased activity of both genes) occurs more commonly in type 2 diabetic patients.	Arginine	35-38	X-ray repair cross complementing 1	Homo sapiens	79-84
19074135-3	2009	In Kv6.x channels the histidine residue of the zinc ion-coordinating C3H1 motif of Kv2.1 is replaced by arginine or valine.	Arginine	104-112	potassium voltage-gated channel subfamily B member 1	Homo sapiens	83-88
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Arginine	124-132	potassium voltage-gated channel subfamily B member 1	Homo sapiens	97-102
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Arginine	124-132	potassium voltage-gated channel subfamily B member 1	Homo sapiens	187-192
19074135-4	2009	Using a yeast two-hybrid assay, we found that substitution of the corresponding histidine 105 in Kv2.1 by valine (H105V) or arginine (H105R) disrupted the interaction of the T1 domain of Kv2.1 with the T1 domains of both Kv6.3 and Kv6.4, whereas interaction of the T1 domain of Kv2.1 with itself was unaffected by this mutation.	Arginine	124-132	potassium voltage-gated channel subfamily B member 1	Homo sapiens	187-192
18951948-1	2009	In previous works, we demonstrated a potent inhibition of diverse protein kinase C (PKC) functions by a fragment of nonstructural protein 3 (NS3) of hepatitis C virus (HCV), mainly mediated by the Arg-rich amino acid motif HCV(1487-1500).	Arginine	197-200	KRAS proto-oncogene, GTPase	Homo sapiens	141-144
19143629-4	2009	Binding of Ca(2+) to EF3 (third EF-hand) enables the side chain of Arg(125), present in the loop connecting EF3 and EF4 (fourth EF-hand), to move sufficiently to make a primary hydrophobic pocket accessible to the critical PPYP (Pro-Pro-Tyr-Pro) motif in Alix, which partially overlaps with the GPP (Gly-Pro-Pro) motif for binding to Cep55 (centrosome protein of 55 kDa).	Arginine	67-70	GTP binding elongation factor GUF1	Homo sapiens	116-119
19293197-5	2009	DNA was isolated from whole blood and beta2-AR gene polymorphisms Arg/Gly16 and Gln/Glu27 were determined using allele-specific polymerase chain reaction [PCR].	Arginine	66-69	adrenoceptor beta 2	Homo sapiens	38-46
19101556-2	2009	We examined and confirmed the arginine methylation of hnRNP K protein by PRMT1, not CARM1, via their direct binding.	Arginine	30-38	protein arginine methyltransferase 1	Homo sapiens	73-78
19158290-4	2009	This effect on axonal stability depends on the RGD domain around arginine 118 in the extracellular portion of MAG, but it is independent of Nogo signaling in the axon.	Arginine	65-73	myelin associated glycoprotein	Homo sapiens	110-113
19272175-3	2009	METHODS: To identify the critical amino acid residues of human EndoG, we replaced the conserved histidine, asparagine, and arginine residues with alanine.	Arginine	123-131	endonuclease G	Homo sapiens	63-68
34697029-7	2021	Serine and Arginine Rich Splicing Factor 2 was implicated in 37.2% of potentially pathogenic events, including Exon5 exclusion in HLA-DMB.	Arginine	11-19	serine and arginine rich splicing factor 1	Homo sapiens	25-42
20104979-5	2009	No association was found with either of the genetic polymorphisms, although the XRCC1 399Arg/Arg genotype was associated with a non-significant higher median survival time (29 months versus 21 months for the Arg/Gln genotype and 15 months for the Gln/Gln genotype, P= 0.09).	Arginine	89-92	X-ray repair cross complementing 1	Homo sapiens	80-85
34515347-2	2021	Here we show that the glycine arginine rich (GAR) domain of nucleolin drives subcellular localization via protein-protein interactions with a kinesin light chain.	Arginine	30-38	nucleolin	Mus musculus	60-69
20104979-5	2009	No association was found with either of the genetic polymorphisms, although the XRCC1 399Arg/Arg genotype was associated with a non-significant higher median survival time (29 months versus 21 months for the Arg/Gln genotype and 15 months for the Gln/Gln genotype, P= 0.09).	Arginine	93-96	X-ray repair cross complementing 1	Homo sapiens	80-85
34424823-0	2021	The RBS1 domain of Gemin5 is intrinsically unstructured and interacts with RNA through conserved Arg and aromatic residues.	Arginine	97-100	gem nuclear organelle associated protein 5	Homo sapiens	19-25
19136629-6	2009	Using both methylation-deficient and methylation-mimicking mutants, we find that arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response.	Arginine	81-89	signal transducer and activator of transcription 1	Homo sapiens	228-233
34424823-6	2021	The combined results of NMR and RNA-binding on wild-type and mutant proteins highlight the importance of aromatic and arginine residues for RNA recognition by RBS1, revealing that the net charge and the pi-amino acid density of this region of Gemin5 are key factors for RNA recognition.	Arginine	118-126	gem nuclear organelle associated protein 5	Homo sapiens	243-249
19136629-9	2009	Our findings identify PRMT1 as a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.	Arginine	133-141	protein arginine methyltransferase 1	Homo sapiens	22-27
34605437-1	2021	The Ca2+-dependent enzyme peptidyl-arginine deiminase type III (PAD3) catalyses the deimination of arginine residues to form citrulline residues in proteins such as keratin, filaggrin and trichohyalin.	Arginine	99-107	peptidyl arginine deiminase 3	Homo sapiens	64-68
19136629-9	2009	Our findings identify PRMT1 as a novel and crucial negative regulator of STAT1 activation that controls PIAS1-mediated repression by arginine methylation.	Arginine	133-141	signal transducer and activator of transcription 1	Homo sapiens	73-78
20214019-3	2009	Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) modulates nitric oxide synthase activity by regulating intracellular L-arginine availability.	Arginine	10-20	arginase 2	Homo sapiens	0-8
34447470-7	2021	Forced expression of HIF-1alpha rescued the protective effect of miR-590-3p on H/R-induced cardiomyocytes.	Arginine	81-82	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	21-31
34635781-3	2021	Protein arginine methyltransferase 1 (Prmt1) is a major enzyme catalyzing asymmetric arginine dimethylation of proteins that are sources of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase.	Arginine	85-93	protein arginine methyltransferase 1	Homo sapiens	0-36
19109200-6	2009	Replacement of only Arg(8) caused already impaired (30-fold reduction) CXCR4 binding and signaling (calcium mobilization, phosphorylation of ERK and protein kinase B) properties.	Arginine	20-23	C-X-C motif chemokine receptor 4	Homo sapiens	71-76
19117199-10	2009	Kinetic data of the present study supported our recently published findings [using single step-solid phase radioimmunoassay (SS-SPRIA)] that the core region of a conformation-specific epitope of hCGbeta consists of Arg (94, 95) and Asp (99) while a Lys (104) and a His (106) are in proximity to the core epitopic region.	Arginine	215-218	chorionic gonadotropin subunit beta 3	Homo sapiens	195-202
18952605-8	2008	Mutation of two arginines located in the core of the putative phosphatidate binding site abolished dioleoyl phosphatidate- and insulin-induced translocation of KSR1.	Arginine	16-25	kinase suppressor of ras 1	Rattus norvegicus	160-164
34635781-3	2021	Protein arginine methyltransferase 1 (Prmt1) is a major enzyme catalyzing asymmetric arginine dimethylation of proteins that are sources of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase.	Arginine	85-93	protein arginine methyltransferase 1	Homo sapiens	38-43
19009525-3	2008	The transmembrane LILRA5 contain a short cytoplasmic domain and a charged arginine residue within the transmembrane region.	Arginine	74-82	leukocyte immunoglobulin like receptor A5	Homo sapiens	18-24
34478713-4	2021	Utilising NAD+, the ecto-enzyme adenosine diphosphate (ADP) ribosyl transferase 2.2 (ART2.2) catalyzes the addition of ADP-ribosyl groups onto arginine residues of CD8alpha or beta chains and alters the interaction between the MHC and TCR complexes.	Arginine	143-151	CD8a molecule	Homo sapiens	164-172
18925426-2	2008	Another therapeutic option proposed is L-arginine, the substrate for the enzyme L-arginine:glycine amidinotransferase (AGAT).	Arginine	39-49	glycine amidinotransferase	Homo sapiens	80-117
34504049-1	2021	Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N-ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants.	Arginine	95-103	vesicle-associated membrane protein 721	Arabidopsis thaliana	50-57
18925426-2	2008	Another therapeutic option proposed is L-arginine, the substrate for the enzyme L-arginine:glycine amidinotransferase (AGAT).	Arginine	39-49	glycine amidinotransferase	Homo sapiens	119-123
34685533-4	2021	The results showed that knockdown of slc38a9 decreased the expression of tor, ribosomal s6 protein kinase (s6k) and eukaryotic translation initiation factor 4e (eif4e) and inhibited the activation of the TOR signaling pathway by arginine.	Arginine	229-237	solute carrier family 38 member 9	Homo sapiens	37-44
18925426-3	2008	We evaluate clinical characteristics and cerebral creatine replenishment after L-arginine therapy in four patients with CRTR-D.	Arginine	79-89	solute carrier family 6 member 8	Homo sapiens	120-124
34685533-7	2021	Supplementation of arginine (0.5-4 mmol/L) increased the expressions of slc38a9, tor, s6k and eif4e in hemocytes, and abalone fed with 1.68% of dietary arginine showed higher mRNA levels of slc38a9, tor, s6k and eif4e and phosphorylation levels of TOR, S6 and 4E-BP.	Arginine	19-27	solute carrier family 38 member 9	Homo sapiens	72-79
34685533-7	2021	Supplementation of arginine (0.5-4 mmol/L) increased the expressions of slc38a9, tor, s6k and eif4e in hemocytes, and abalone fed with 1.68% of dietary arginine showed higher mRNA levels of slc38a9, tor, s6k and eif4e and phosphorylation levels of TOR, S6 and 4E-BP.	Arginine	19-27	solute carrier family 38 member 9	Homo sapiens	190-197
18842000-3	2008	The crystal structure of the BARD1 BRCT domain uncovers a degenerate phosphopeptide binding pocket lacking the key arginine required for phosphopeptide interactions in other BRCT proteins.	Arginine	115-123	BRCA1 associated RING domain 1	Homo sapiens	29-34
34685533-7	2021	Supplementation of arginine (0.5-4 mmol/L) increased the expressions of slc38a9, tor, s6k and eif4e in hemocytes, and abalone fed with 1.68% of dietary arginine showed higher mRNA levels of slc38a9, tor, s6k and eif4e and phosphorylation levels of TOR, S6 and 4E-BP.	Arginine	152-160	solute carrier family 38 member 9	Homo sapiens	72-79
34685533-7	2021	Supplementation of arginine (0.5-4 mmol/L) increased the expressions of slc38a9, tor, s6k and eif4e in hemocytes, and abalone fed with 1.68% of dietary arginine showed higher mRNA levels of slc38a9, tor, s6k and eif4e and phosphorylation levels of TOR, S6 and 4E-BP.	Arginine	152-160	solute carrier family 38 member 9	Homo sapiens	190-197
18925773-6	2008	Indeed, the MALDI-MS/MS identification of the CARM1 proteolytic cleavage site, which happens in a Lys/Arg/His free domain, could only be achieved using the DHB matrix.	Arginine	102-105	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
34638549-4	2021	In this work, we dissect the molecular mechanisms eliciting the endocytosis of Can1, the arginine permease, in response to cycloheximide-induced TORC1 hyperactivation.	Arginine	89-97	arginine permease CAN1	Saccharomyces cerevisiae S288C	79-83
34573721-3	2021	The main results show the crucial role of arginine in the viability/proliferation of intestinal cells evaluated by an MTT assay, and in the positive regulation of the expression of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6, IL-8) and anti-inflammatory (TGF-beta) cytokines.	Arginine	42-50	transforming growth factor alpha	Sus scrofa	256-264
18452209-14	2008	This Arg residue is next to the conserved Leu residue and is replaced by Ala in Bak.	Arginine	5-8	BCL2 antagonist/killer 1	Homo sapiens	80-83
34325101-5	2021	The ARG composition was differently impacted by rapid urbanization and dam construction, which urbanization could promote ARGs resistant to sulfonamide and tetracycline, whereas dam construction could elevate the resistance to chloramphenicol and aminoglycoside.	Arginine	4-7	serpin family A member 2 (gene/pseudogene)	Homo sapiens	122-126
34325101-8	2021	We found that human-impacted environments harbored high proportion of mobile genetic elements (MGEs), and the MGE carrying ARGs also increased under anthropogenic disturbances in the pathogenic hosts, which confirmed that anthropogenic activities could promote ARG horizontal gene transfer.	Arginine	261-264	serpin family A member 2 (gene/pseudogene)	Homo sapiens	123-127
18616983-9	2008	The inhibitory effect of leucine, isoleucine or arginine on MuRF1 mRNA levels was not reversed by rapamycin.	Arginine	48-56	tripartite motif-containing 63	Mus musculus	60-65
18824591-5	2008	To clarify the features of gating pore currents arising from different DIIS4 mutants, we recorded gating pore currents created by HypoPP missense mutations at position R666 in the rat isoform of Nav1.4 (the second arginine from the outside, at R672 in human NaV1.4).	Arginine	214-222	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	195-201
34816671-12	2021	Conclusion: Dezocine can reduce oxidative stress and apoptosis of rat cardiomyocytes H9C2 induced by H/R, which may play a role in regulating the miR-7a-5p / TRIM10 axis.	Arginine	103-104	tripartite motif-containing 10	Rattus norvegicus	158-164
18644376-5	2008	A positively charged arginine at position 512 in the n-Src loop of Eps8L1 SH3 plays a key role in PxxDY motif recognition by forming a salt bridge to D7 of the CD3epsilon peptide.	Arginine	21-29	EPS8 like 1	Homo sapiens	67-73
34525929-9	2021	Then, multivariate Cox regression analysis was used to determine 4 key prognostic ARGs (CC3CL1, ERBB2, HIF-alpha and CXCR4) in WT.	Arginine	82-86	C-X-C motif chemokine receptor 4	Homo sapiens	117-122
18801197-0	2008	Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods.	Arginine	34-42	N-acetylglutamate synthase	Homo sapiens	46-72
18801197-4	2008	NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis.	Arginine	134-142	N-acetylglutamate synthase	Homo sapiens	33-59
18801197-4	2008	NAG is produced enzymatically by N-acetylglutamate synthase (NAGS), which is also found in bacteria and plants as the first enzyme of arginine biosynthesis.	Arginine	134-142	N-acetylglutamate synthase	Homo sapiens	61-65
34440879-4	2021	Additionally, activated GPIIb/IIIa complex (PAC-1) expression was higher on platelets from severe COVID-19 patients compared to healthy controls and inversely correlated with L-arginine plasmatic concentration.	Arginine	175-185	integrin subunit alpha 2b	Homo sapiens	24-29
18801197-5	2008	Arginine is an allosteric inhibitor of microbial and plant NAGS, and allosteric activator of mammalian NAGS.	Arginine	0-8	N-acetylglutamate synthase	Homo sapiens	59-63
18801197-5	2008	Arginine is an allosteric inhibitor of microbial and plant NAGS, and allosteric activator of mammalian NAGS.	Arginine	0-8	N-acetylglutamate synthase	Homo sapiens	103-107
18801197-6	2008	RESULTS: Information from mutagenesis studies of E. coli and P. aeruginosa NAGS was combined with structural information from the related bacterial N-acetylglutamate kinases to identify four residues in mammalian NAGS that interact with arginine.	Arginine	237-245	N-acetylglutamate synthase	Homo sapiens	213-217
18700728-1	2008	Protein arginine methyltransferase 1 (PRMT1) catalyzes the mono- and dimethylation of certain protein arginine residues.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
34539989-11	2021	RESULTS: CircUBXN7 was downregulated in patients and mice with AMI, as well as in H/R-treated cells.	Arginine	84-85	UBX domain protein 7	Homo sapiens	9-18
18466879-7	2008	CONCLUSIONS: The ancestral allele (Arg) of the nonsynonymous common DAOA variant rs2391191 (Arg30Lys) was found to predispose to impaired performance.	Arginine	35-38	D-amino acid oxidase activator	Homo sapiens	68-72
34445292-3	2021	Our studies have determined that an isoform of ERAP2-arginine (N), expressed in trophoblast cells (TC), significantly activates immune cells, and ERAP2N-expressing TCs are preferentially killed by both cytotoxic T lymphocytes (CTLs) and Natural Killer cells (NKCs).	Arginine	53-61	endoplasmic reticulum aminopeptidase 2	Homo sapiens	47-52
34171297-0	2021	Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.	Arginine	0-8	protein arginine methyltransferase 7	Homo sapiens	28-33
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	protein arginine methyltransferase 7	Homo sapiens	0-36
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	protein arginine methyltransferase 7	Homo sapiens	38-43
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	DExD/H-box helicase 58	Homo sapiens	163-168
34171297-4	2021	Upon virus infection, aggregated PRMT7 is disabled in a timely manner due to automethylation at arginine residue 32 (R32), and SMURF1 is recruited to PRMT7 by MAVS to induce proteasomal degradation of PRMT7, resulting in the relief of PRMT7 suppression of MAVS activation.	Arginine	96-104	protein arginine methyltransferase 7	Homo sapiens	33-38
18515377-0	2008	Gating consequences of charge neutralization of arginine residues in the S4 segment of K(v)7.2, an epilepsy-linked K+ channel subunit.	Arginine	48-56	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	87-94
34171297-4	2021	Upon virus infection, aggregated PRMT7 is disabled in a timely manner due to automethylation at arginine residue 32 (R32), and SMURF1 is recruited to PRMT7 by MAVS to induce proteasomal degradation of PRMT7, resulting in the relief of PRMT7 suppression of MAVS activation.	Arginine	96-104	protein arginine methyltransferase 7	Homo sapiens	235-240
34171297-5	2021	Therefore, we not only reveal that arginine monomethylation by PRMT7 negatively regulates MAVS-mediated antiviral signaling in vitro and in vivo but also uncover a mechanism by which PRMT7 is tightly controlled to ensure the timely activation of antiviral defense.	Arginine	35-43	protein arginine methyltransferase 7	Homo sapiens	63-68
34171297-5	2021	Therefore, we not only reveal that arginine monomethylation by PRMT7 negatively regulates MAVS-mediated antiviral signaling in vitro and in vivo but also uncover a mechanism by which PRMT7 is tightly controlled to ensure the timely activation of antiviral defense.	Arginine	35-43	protein arginine methyltransferase 7	Homo sapiens	183-188
34344457-14	2021	However, upregulation of ARG2 in CAFs may divert Arg from TILs, allowing immune escape.	Arginine	49-52	arginase 2	Homo sapiens	25-29
18515377-3	2008	The benign familial neonatal seizure-causing mutations include those at arginine residues at positions 207 and 214 in the S(4) segment of K(v)7.2.	Arginine	72-80	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	138-145
18515377-5	2008	The results obtained suggest that each S(4) arginine residue plays a relevant role in the voltage-dependent gating of K(v)7.2 channels.	Arginine	44-52	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	118-125
18554750-3	2008	The mutant, called long bone abnormality (lbab), contains a single point mutation that converts an arginine to a glycine in a conserved coding region of the CNP gene, but how this mutation affects CNP activity has not been reported.	Arginine	99-107	natriuretic peptide type C	Mus musculus	157-160
34326297-8	2022	Furthermore, we found that PRMT7 mainly binds to residues 563-566 within the first intracellular loop of hNaV1.9 (hLoop1) and methylates hLoop1 at arginine residue 519.	Arginine	147-155	protein arginine methyltransferase 7	Homo sapiens	27-32
18660432-1	2008	CARM1/PRMT4 (for COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE1/PROTEIN ARGININE METHYLTRANSFERASE4) catalyzes asymmetric dimethylation on arginine (Arg), and its functions in gene regulation is understood only in animal systems.	Arginine	143-151	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
18660432-1	2008	CARM1/PRMT4 (for COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE1/PROTEIN ARGININE METHYLTRANSFERASE4) catalyzes asymmetric dimethylation on arginine (Arg), and its functions in gene regulation is understood only in animal systems.	Arginine	143-151	coactivator associated arginine methyltransferase 1	Homo sapiens	6-11
18660432-1	2008	CARM1/PRMT4 (for COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE1/PROTEIN ARGININE METHYLTRANSFERASE4) catalyzes asymmetric dimethylation on arginine (Arg), and its functions in gene regulation is understood only in animal systems.	Arginine	153-156	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
34336974-6	2021	These results are confirmed by a docking study showing the perfect positioning of juglone in the MPO enzyme active site and its interaction with one of the amino acids (Arg-239) of MPO apoprotein.	Arginine	169-172	myeloperoxidase	Equus caballus	97-100
34336974-6	2021	These results are confirmed by a docking study showing the perfect positioning of juglone in the MPO enzyme active site and its interaction with one of the amino acids (Arg-239) of MPO apoprotein.	Arginine	169-172	myeloperoxidase	Equus caballus	181-184
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Arginine	120-128	argininosuccinate lyase	Homo sapiens	203-206
34298755-2	2021	Yet, it is also considered as a non- or semi-essential amino acid, due to normal cells" intrinsic ability to synthesize arginine from citrulline and aspartate via ASS1 (argininosuccinate synthase 1) and ASL (argininosuccinate lyase).	Arginine	120-128	argininosuccinate lyase	Homo sapiens	208-231
34252134-7	2021	Similarly, we introduced lysine-to-arginine mutations in constitutively active Rac1 to inhibit site-specific ubiquitination and analyze this effect on Rac1 signaling output and ubiquitination.	Arginine	35-43	Rac family small GTPase 1	Homo sapiens	79-83
34244496-0	2021	Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1.	Arginine	0-8	Piwi domain-containing protein	Caenorhabditis elegans	120-125
34356607-5	2021	Molecular modelling and binding energy calculation indicated that residues flanking the key Arg in the collagen sequence also play an important role in defining the high-affinity HSP47 binding site of collagen.	Arginine	92-95	serpin family H member 1	Homo sapiens	179-184
34356607-6	2021	Based on this binding mode of HSP47 to collagen, virtual screening targeting both the Arg binding site and its neighboring area on the HSP47 surface, and a subsequent bioassay, we identified two novel compounds with blocking activity towards HSP47 binding of collagen.	Arginine	86-89	serpin family H member 1	Homo sapiens	30-35
34356607-6	2021	Based on this binding mode of HSP47 to collagen, virtual screening targeting both the Arg binding site and its neighboring area on the HSP47 surface, and a subsequent bioassay, we identified two novel compounds with blocking activity towards HSP47 binding of collagen.	Arginine	86-89	serpin family H member 1	Homo sapiens	135-140
34239351-9	2021	The structural characteristics of key pathway components and PYCR1-interacting proteins were evaluated by molecular docking, and hotspot analysis showed that better affinities between PYCR1 and its interacting molecules were associated with the presence of arginine in the binding site.	Arginine	257-265	pyrroline-5-carboxylate reductase 1	Homo sapiens	61-66
34239351-9	2021	The structural characteristics of key pathway components and PYCR1-interacting proteins were evaluated by molecular docking, and hotspot analysis showed that better affinities between PYCR1 and its interacting molecules were associated with the presence of arginine in the binding site.	Arginine	257-265	pyrroline-5-carboxylate reductase 1	Homo sapiens	184-189
34093497-6	2021	MxB preserves its anti-HIV-1 activity when its N-terminal sequence is replaced by the arginine-rich NLS.	Arginine	86-94	MX dynamin like GTPase 2	Homo sapiens	0-3
34093497-7	2021	Interestingly, the arginine-rich NLS allows MxB to inhibit HIV-1 CA mutants that are otherwise resistant to wild type MxB, which suggests sequence specific targeting of viral capsid.	Arginine	19-27	MX dynamin like GTPase 2	Homo sapiens	44-47
35501630-3	2022	Heterozygous patients with an arginine to cysteine mutation in MPZ (MPZR98C) develop a severe infantile form of CMT1B which is modelled by MpzR98C/ + mice that also show ER stress and an activated UPR.	Arginine	30-38	myelin protein zero	Homo sapiens	112-117
35583463-6	2022	Furthermore, l -arginine contributed to the expression of phase II detoxification genes (SULT2B1, GSTA1, GSTM3, and GPX4).	Arginine	13-24	glutathione S-transferase mu 3	Homo sapiens	105-110
35583463-7	2022	l-Arginine addition also increased the protein levels of LC3-II and Beclin 1, and downregulated p62/SQSTM1 levels, indicating its regulatory roles in autophagic flux activation upon ZEA exposure.	Arginine	0-10	beclin 1	Homo sapiens	68-76
35583463-7	2022	l-Arginine addition also increased the protein levels of LC3-II and Beclin 1, and downregulated p62/SQSTM1 levels, indicating its regulatory roles in autophagic flux activation upon ZEA exposure.	Arginine	0-10	sequestosome 1	Homo sapiens	96-99
35583463-7	2022	l-Arginine addition also increased the protein levels of LC3-II and Beclin 1, and downregulated p62/SQSTM1 levels, indicating its regulatory roles in autophagic flux activation upon ZEA exposure.	Arginine	0-10	sequestosome 1	Homo sapiens	100-106
35609127-5	2022	PILA promoted PRMT1-mediated arginine methylation of DExH-box helicase 9 (DHX9), leading to an increase in the transcription of the gene encoding transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of NF-kappaB signaling.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	14-19
35580065-7	2022	In HEK293T cells expressing human KCNQ1 and KCNE1, inhibiting PRMT1 via furamidine reduced IKs and concurrently decreased the arginine methylation of KCNQ1, a pore-forming alpha-subunit.	Arginine	126-134	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	44-49
35580065-7	2022	In HEK293T cells expressing human KCNQ1 and KCNE1, inhibiting PRMT1 via furamidine reduced IKs and concurrently decreased the arginine methylation of KCNQ1, a pore-forming alpha-subunit.	Arginine	126-134	protein arginine methyltransferase 1	Homo sapiens	62-67
35149504-7	2022	Mechanism investigation revealed that  O2- and 1O2 were the vital reactive species for ARB inactivation and ARG degradation.	Arginine	108-111	immunoglobulin kappa variable 1D-39	Homo sapiens	39-50
35567594-1	2022	PURPOSE: SRRM2 encodes the SRm300 protein, a splicing factor of the SR-related protein family characterized by its serine- and arginine-enriched domains.	Arginine	127-135	serine/arginine repetitive matrix 2	Homo sapiens	9-14
35567594-1	2022	PURPOSE: SRRM2 encodes the SRm300 protein, a splicing factor of the SR-related protein family characterized by its serine- and arginine-enriched domains.	Arginine	127-135	serine/arginine repetitive matrix 2	Homo sapiens	27-33
35543513-11	2022	In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK) encoded by the ARG5,6 gene catalyzes the second step in ornithine and arginine biosynthesis, and its activity is subjected to feedback inhibition by arginine.	Arginine	142-150	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	87-93
35543513-11	2022	In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK) encoded by the ARG5,6 gene catalyzes the second step in ornithine and arginine biosynthesis, and its activity is subjected to feedback inhibition by arginine.	Arginine	221-229	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	87-93
35442666-3	2022	The cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1) is a crucial upstream regulator of the mechanistic target of rapamycin complex 1 (mTORC1) signaling, which has close connections with apoptosis.	Arginine	14-22	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	52-59
35393860-4	2022	The positron emission tomography (PET) imaging tracer, 68Ga-labeled antagonist peptide Trp-Arg-Trp-Trp-Trp-Trp (WRWWWW, WRW4), targets formyl peptide receptor 2 (FPR2), which is in turn widely distributed in a variety of tissues and is associated with many inflammatory diseases.	Arginine	91-94	formyl peptide receptor 2	Mus musculus	135-160
35611768-4	2022	In vitro experiments showed increased circ-RBMS1 and decreased miR-2355-3p in H/R-induced HCMs.	Arginine	80-81	RNA binding motif single stranded interacting protein 1	Homo sapiens	43-48
35490408-2	2022	Mammalian cells expressing CaMKKalpha and CaMKKbeta lacking Arg/Pro-rich insert domain (RP-domain) sequences showed impaired phosphorylation of AMPKalpha, CaMKIalpha, and CaMKIV, whereas the autophosphorylation activities of CaMKK mutants remained intact and were similar to those of wild type CaMKKs.	Arginine	60-63	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	27-37
35490408-2	2022	Mammalian cells expressing CaMKKalpha and CaMKKbeta lacking Arg/Pro-rich insert domain (RP-domain) sequences showed impaired phosphorylation of AMPKalpha, CaMKIalpha, and CaMKIV, whereas the autophosphorylation activities of CaMKK mutants remained intact and were similar to those of wild type CaMKKs.	Arginine	60-63	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	42-51
35490408-2	2022	Mammalian cells expressing CaMKKalpha and CaMKKbeta lacking Arg/Pro-rich insert domain (RP-domain) sequences showed impaired phosphorylation of AMPKalpha, CaMKIalpha, and CaMKIV, whereas the autophosphorylation activities of CaMKK mutants remained intact and were similar to those of wild type CaMKKs.	Arginine	60-63	calcium/calmodulin dependent protein kinase I	Homo sapiens	155-165
35414328-14	2022	Finally, based on the correlation between each ARG and its prognostic signature, three modules of AR-lncRNA-miRNA-mRNA regulatory networks were constructed based on 6 AR-lncRNAs, 17 miRNAs, and 12 ARGs.	Arginine	47-50	serpin family A member 2 (gene/pseudogene)	Homo sapiens	197-201
35245741-2	2022	Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that catalyzes dimethylation of histone H3 (H3R17) at arginine 17.	Arginine	147-155	coactivator associated arginine methyltransferase 1	Homo sapiens	0-51
35245741-2	2022	Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that catalyzes dimethylation of histone H3 (H3R17) at arginine 17.	Arginine	147-155	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
35462078-8	2022	Interestingly, we found two Arginine fingers R68 and R149 that directly interact with the beta-phosphate of the GTP bound in KRas, in a manner similar to what is observed in a crystal structure of GAP-HRas complex, which can facilitate the GPT hydrolysis via the Arginine finger of GTPase-activating protein (GAP).	Arginine	28-36	KRAS proto-oncogene, GTPase	Homo sapiens	125-129
35403872-7	2022	Mutation of this residue to arginine (K744R), which is also associated with several human disorders, including dyschromatosis symmetrica hereditaria (DSH) and some types of cancer, abolished SMURF2-mediated protection of ADAR1p110 from both proteasomal and lysosomal degradation and inactivated ADAR1p110-mediated RNA editing.	Arginine	28-36	SMAD specific E3 ubiquitin protein ligase 2	Homo sapiens	191-197
35220691-2	2022	Coactivator-associated arginine methyltransferase (Carm1, also known as Prmt4) participates in various cellular events, such as cell survival, proliferation, and differentiation through its protein arginine methylation activities.	Arginine	198-206	coactivator associated arginine methyltransferase 1	Homo sapiens	72-77
34998113-2	2022	The objective of this study was to investigate age-dependent changes in the daily regulation of Arg-Phe amide-related peptide-3 (RFRP-3), a hypothalamic peptide involved in reproduction, in female C57BL/6 J mice of different age groups (4, 13, and 19 months old) sampled at their diestrus stage.	Arginine	96-99	renin binding protein	Mus musculus	47-50
35409175-0	2022	Effect of Betaine and Arginine on Interaction of alphaB-Crystallin with Glycogen Phosphorylase b.	Arginine	22-30	glycogen phosphorylase B	Homo sapiens	72-96
35391841-13	2022	These findings highlight a new mechanism of Rg2-induced cardioprotection: reducing the formation of RIP1/RIP3 necrosome by regulating TAK1 phosphorylation to block necroptosis induced by MI/R.	Arginine	190-191	receptor-interacting serine-threonine kinase 3	Mus musculus	105-109
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	BCL2 antagonist/killer 1	Homo sapiens	93-97
35195559-8	2022	Furthermore, an ARG signature was established based on overall survival-related ARGs (CASP4, BAK1, PIK3R4, CASP8, BIRC5, RPTOR, and CAPN1) using least absolute shrinkage and selection operator (LASSO) regression.	Arginine	16-19	baculoviral IAP repeat containing 5	Homo sapiens	114-119
35199385-7	2022	Protein-protein interaction and transcription factor analyses suggested that Trp53 and Nr4a2 genes may play key roles during arginine stimulation.	Arginine	125-133	nuclear receptor subfamily 4, group A, member 2	Mus musculus	87-92
35120671-7	2022	The ProP 1.0 Server, a neural network prediction tool, predicted the presence of a cleavage site at the substituted arginine residue (p.Q44R) of NPPC.	Arginine	116-124	natriuretic peptide C	Homo sapiens	145-149
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	kelch-like ECH-associated protein 1	Mus musculus	107-112
35342347-6	2022	Subsequently, molecular docking and dynamics simulation study revealed a binding mode between UA and Nrf-2/Keap1 including the hydrogen-bonding network among oxygen atoms in UA with the Nrf-2/Keap1 residues Arg 415, Ser 508 and Ser 602, which in turn trigger Nrf2 nuclear translocation, subsequently leading to activation of Nrf-2 target genes (HO-1, NQO1).	Arginine	207-210	kelch-like ECH-associated protein 1	Mus musculus	192-197
35269695-2	2022	Structurally, CHERP carries the nuclear localization signal and arginine/serine-dipeptide repeats, like domain, and interacts with the spliceosome.	Arginine	64-72	calcium homeostasis endoplasmic reticulum protein	Homo sapiens	14-19
35174171-6	2021	Our docking results also revealed that ARG-120, TRP-126, and HIS-187 were critical sites responsible for interaction of SIRT7 with small molecules.	Arginine	39-42	sirtuin 7	Homo sapiens	120-125
35085371-5	2022	We also reported SG assembly dynamics is dependent on the arginine-methylation status of G3BP1.	Arginine	58-66	G3BP stress granule assembly factor 1	Homo sapiens	89-94
18660432-1	2008	CARM1/PRMT4 (for COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE1/PROTEIN ARGININE METHYLTRANSFERASE4) catalyzes asymmetric dimethylation on arginine (Arg), and its functions in gene regulation is understood only in animal systems.	Arginine	153-156	coactivator associated arginine methyltransferase 1	Homo sapiens	6-11
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	81-84	protein arginine methyltransferase 4B	Arabidopsis thaliana	25-33
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	88-91	protein arginine methyltransferase 4B	Arabidopsis thaliana	25-33
18660432-3	2008	Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in vitro.	Arginine	88-91	protein arginine methyltransferase 4B	Arabidopsis thaliana	25-33
18660432-8	2008	Finally, we found that asymmetric methylation at Arg-17 of histone H3 was greatly reduced in atprmt4a atprmt4b double mutants.	Arginine	49-52	protein arginine methyltransferase 4B	Arabidopsis thaliana	102-110
35064085-0	2022	TRITHORAX-dependent arginine methylation of HSP68 mediates circadian repression by PERIOD in the monarch butterfly.	Arginine	20-28	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	0-9
35064085-7	2022	Our results show that TRX catalytic activity is essential for CLK-PER interaction and PER repression via the methylation of a single arginine methylation site (R45) on heat shock protein 68 (HSP68).	Arginine	133-141	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	22-25
18541532-10	2008	Mutation of an arginine that aligned with an arginine presumed to be catalytic in ASAP1 abrogated activity.	Arginine	15-23	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	82-87
18541532-10	2008	Mutation of an arginine that aligned with an arginine presumed to be catalytic in ASAP1 abrogated activity.	Arginine	45-53	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	82-87
18816294-11	2008	Notably, cotreatment with L-arginine reversed most of these changes except for SSAT expression,which was further up-regulated.	Arginine	26-36	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	79-83
34610138-19	2022	Meanwhile, the changes in muscle arginine concentration following acute EWP, ALB, and CAS administration paralleled those of muscle growth.	Arginine	33-41	albumin	Rattus norvegicus	77-80
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	Arginine	62-63	intercellular adhesion molecule 1	Homo sapiens	104-109
18028947-11	2008	CONCLUSIONS: HO-1 overexpression significantly attenuates endotoxin-induced increases in NO production and l-arginine transport.	Arginine	107-117	heme oxygenase 1	Rattus norvegicus	13-17
18485777-3	2008	Sequencing of the PNPO gene revealed a novel homozygous c.284G>A transition in exon 3, resulting in arginine to histidine substitution and reduced activity of the PNPO mutant to 18% relative to the wild type.	Arginine	100-108	pyridoxamine 5'-phosphate oxidase	Homo sapiens	18-22
18590276-1	2008	Prothrombinase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	65-68	coagulation factor X	Homo sapiens	0-14
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	243-246	insulin like growth factor 1 receptor	Homo sapiens	195-209
18502759-4	2008	So far IGF-I residues structurally corresponding to the residues of the insulin site 1 together with residues in the C-domain of IGF-I have been found to be important for binding of IGF-I to the IGF-I receptor (e.g. Phe(23), Tyr(24), Tyr(31), Arg(36), Arg(37), Val(44), Tyr(60), and Ala(62)).	Arginine	252-255	insulin like growth factor 1 receptor	Homo sapiens	195-209
18480452-3	2008	Histone acetyltransferases, including p300 and hGCN5, not only acetylate histones but also acetylate Tat at lysine positions 50 and 51 in the arginine-rich motif.	Arginine	142-150	lysine acetyltransferase 2A	Homo sapiens	47-52
18705864-11	2008	Site-directed mutagenesis confirmed that a threonine residue is absolutely required for RPP13 recognition and that recognition can be modulated by the presence of either an arginine or glutamic acid at other sites.	Arginine	173-181	NB-ARC domain-containing disease resistance protein	Arabidopsis thaliana	88-93
18426798-4	2008	Our data suggest that a salt bridge between Arg-60 in the N terminus close to the cytoplasmic end of transmembrane segment (TM) 1 and Asp-436 at the cytoplasmic end of TM8 is stabilized by a cation-pi interaction between Arg-60 and Tyr-335 at the cytoplasmic end of TM6.	Arginine	44-47	tetraspanin 16	Homo sapiens	168-171
18426798-4	2008	Our data suggest that a salt bridge between Arg-60 in the N terminus close to the cytoplasmic end of transmembrane segment (TM) 1 and Asp-436 at the cytoplasmic end of TM8 is stabilized by a cation-pi interaction between Arg-60 and Tyr-335 at the cytoplasmic end of TM6.	Arginine	221-224	tetraspanin 16	Homo sapiens	168-171
18359766-5	2008	Using structure-based mutagenesis of a Robo IG1-5 construct we identified key Slit binding residues (Thr-74, Phe-114, Arg-117) forming a conserved patch on the surface of IG1; mutation of similarly conserved residues in IG2 had no effect on Slit binding.	Arginine	118-121	roundabout 1	Drosophila melanogaster	39-43
18627343-6	2008	KLK4, 5, and 6 exhibit trypsin-like specificity, with a strong preference for Arg at the P1 position of substrates.	Arginine	78-81	kallikrein related peptidase 4	Homo sapiens	0-4
18714823-5	2008	beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg--&gt;Gly) and 27 (beta2-AR-27: Gln--&gt;Glu) were identified by PCR-RFLP.	Arginine	83-86	adrenoceptor beta 2	Homo sapiens	0-8
18499102-5	2008	To this direction, we have evolved an integrated PCR-based molecular protocol, which through the utilization of novel "exonic" primers allows, among others, the structural analysis of the 13th exon of the human beta-myosin heavy chain gene locus (MYH7) mainly characterized by the critical for HCM Arginine residue 403 (R(403)).	Arginine	298-306	myosin heavy chain 7	Homo sapiens	247-251
18266916-8	2008	The ibo1-1 mutation, in which a conserved Glu residue in the activation loop is substituted by Arg, completely abolishes its kinase activity.	Arginine	95-98	serine/threonine-protein kinase NEK5	Arabidopsis thaliana	4-8
18283102-1	2008	Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor.	Arginine	104-112	H4 clustered histone 4	Homo sapiens	181-186
18283102-1	2008	Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor.	Arginine	114-117	H4 clustered histone 4	Homo sapiens	181-186
18283102-2	2008	During Arg hydroxylation, H(4)B acts as a one-electron donor and is then presumed to redox cycle (i.e. be reduced back to H(4)B) within NOS before further catalysis can proceed.	Arginine	7-10	H4 clustered histone 4	Homo sapiens	26-31
18283102-2	2008	During Arg hydroxylation, H(4)B acts as a one-electron donor and is then presumed to redox cycle (i.e. be reduced back to H(4)B) within NOS before further catalysis can proceed.	Arginine	7-10	H4 clustered histone 4	Homo sapiens	122-127
18250167-3	2008	Here, we report a novel K(ATP) channel gating defect caused by CHI-associated Kir6.2 mutations at arginine 301 (to cysteine, glycine, histidine, or proline).	Arginine	98-106	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	78-84
18250167-5	2008	Based on the crystal structures of Kir3.1 and KirBac1.1, Arg-301 interacts with several residues in the neighboring Kir6.2 subunit.	Arginine	57-60	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	116-122
18201801-6	2008	In contrast, discharge activity of GD-responsive neurons with motilin was enhanced by pretreatment of NO precursor l-arginine.	Arginine	115-125	motilin	Rattus norvegicus	62-69
18359858-6	2008	KLK6 displayed trypsin-like activity, with the P1 position occupied only by Arg and a strong preference for Ser in P1".	Arginine	76-79	kallikrein related peptidase 6	Homo sapiens	0-4
18080148-8	2008	Homozygosity for the Arg allele of Col9A2 seems to be more frequent in the patient group with early recurrence although the differences in the allele frequencies were statistically not significant.	Arginine	21-24	collagen type IX alpha 2 chain	Homo sapiens	35-41
18319565-4	2008	Mutations that changed Asn616 of the NR1a subunit, a critical residue for Mg(2+) blocking of NMDA receptors, to Arg (N616R) or Gln (N616Q) almost eliminated the inhibitory effects of timolol and betaxolol, as well as the blocking effect of Mg(2+).	Arginine	112-115	nodal homolog 1 L homeolog	Xenopus laevis	37-41
18179643-2	2008	Two allelic dimorphisms of these receptors, valine/phenylalanine-158 of CD16A and histidine/arginine-131 of CD32A, modulate their affinity for certain human IgG subclasses.	Arginine	92-100	Fc gamma receptor IIIa	Homo sapiens	72-77
18709962-0	2008	[Transthyretin Arg-83 mutation in vitreous amyloidosis].	Arginine	15-18	transthyretin	Homo sapiens	1-14
18709962-7	2008	Bi-directional sequencing of exon 3 showed a single base-pair substitution, which results in an amino acid substitution at position83, glycine to arginine (TTR Arg-83).	Arginine	146-154	transthyretin	Homo sapiens	156-159
17904828-2	2008	For this purpose chitosan membranes were prepared and then photochemically modified with the cell adhesive peptide RGDS (Arg-Gly-Asp-Ser).	Arginine	121-124	ral guanine nucleotide dissociation stimulator	Mus musculus	115-119
18065761-5	2008	In silico docking calculations partnered with our crystal structures support the importance of arginine residues in positions 29, 42, and 77 in binding sulfate groups of the dp8 and dp10 forms of heparin.	Arginine	95-103	dipeptidyl peptidase 8	Homo sapiens	174-177
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	145-148	spleen trypsin inhibitor I	Bos taurus	38-42
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	145-148	spleen trypsin inhibitor I	Bos taurus	157-161
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	145-148	spleen trypsin inhibitor I	Bos taurus	157-161
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	162-165	spleen trypsin inhibitor I	Bos taurus	38-42
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	162-165	spleen trypsin inhibitor I	Bos taurus	157-161
18077447-7	2008	Our results show that the mesotrypsin-BPTI interface favors catalysis through (a) electrostatic repulsion between the closely spaced mesotrypsin Arg-193 and BPTI Arg-17, and (b) elimination of two hydrogen bonds between the enzyme and the amine leaving group portion of BPTI.	Arginine	162-165	spleen trypsin inhibitor I	Bos taurus	157-161
18281463-7	2008	Strikingly, mutation of the two lysines at the NLS to arginines, or coexpression of a SUMO protease with wild-type PAP, caused PAP to be localized to the cytoplasm, demonstrating that sumoylation is required to facilitate PAP nuclear localization.	Arginine	54-63	poly(A) polymerase alpha	Homo sapiens	127-130
18281463-7	2008	Strikingly, mutation of the two lysines at the NLS to arginines, or coexpression of a SUMO protease with wild-type PAP, caused PAP to be localized to the cytoplasm, demonstrating that sumoylation is required to facilitate PAP nuclear localization.	Arginine	54-63	poly(A) polymerase alpha	Homo sapiens	127-130
18029351-7	2008	Incubation of cultured cells with the iNOS substrate L-arginine and NO donor significantly increased cPLA(2)alpha activity and AA release.	Arginine	53-63	phospholipase A2 group IVA	Homo sapiens	101-113
18083825-12	2008	Mutational analysis revealed that two arginine residues in the N-terminal region of Mnn9p are important for the chimeric protein to cycle between the endoplasmic reticulum and the Golgi apparatus.	Arginine	38-46	mannosyltransferase complex subunit MNN9	Saccharomyces cerevisiae S288C	84-89
17974564-3	2008	Here we have used mutagenesis, radioligand binding, voltage clamp electrophysiology, and homology modeling to probe the role of the F-loop residues Asp(192)-Arg(197) in the GABA(A) receptor gamma(2) subunit in diazepam potentiation of the GABA response.	Arginine	157-160	gamma-aminobutyric acid type A receptor subunit gamma2	Homo sapiens	173-198
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Arginine	24-32	solute carrier family 7 member 1	Homo sapiens	47-80
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Arginine	24-32	solute carrier family 7 member 1	Homo sapiens	82-86
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Arginine	106-114	solute carrier family 7 member 1	Homo sapiens	47-80
18574322-1	2008	We recently showed that arginine transport via cationic amino acid transporter 1 (CAT1), which transports arginine, lysine, ornithine, and histidine, is essential for erythropoiesis.	Arginine	106-114	solute carrier family 7 member 1	Homo sapiens	82-86
18756768-10	2008	MPTP inhibition is dependent on paradoxycally high activation by ecdusterone of oxidative degradation of L-arginine by mtcNOS in mitochondria, by downregulation of superoxide generation and L-arginine degradation by arginase II and NO generation by mtiNOS in de novo and by NADP-dependent mtNR (nitrate reductase) in salvage pathways.	Arginine	105-115	arginase 2	Rattus norvegicus	216-227
18156399-0	2008	Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis.	Arginine	0-8	annexin A6	Homo sapiens	30-33
18156399-2	2008	In this study, we hypothesized that during rotavirus infection, oral Arg, which stimulates p70(S6k) activation, will further stimulate intestinal protein synthesis and mucosal recovery, whereas the p70(S6k) inhibitor rapamycin (Rapa) will inhibit mucosal recovery.	Arginine	69-72	annexin A6	Homo sapiens	91-94
18156399-10	2008	However, in Arg-treated piglets, p70(S6k) activation occurred over the entire villus.	Arginine	12-15	annexin A6	Homo sapiens	33-36
18156399-12	2008	We conclude that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70(S6k)-independent mechanism.	Arginine	48-51	annexin A6	Homo sapiens	131-134
18214807-6	2008	Among exposed workers, subjects with the combination of MPO G/G and XRCC1 Arg/Gln or Gln/Gln showed a significantly higher CA frequency compared to those with the combination of MPO G/A or A/A and XRCC1 Arg/Arg genotypes.	Arginine	203-206	X-ray repair cross complementing 1	Homo sapiens	197-202
18214807-6	2008	Among exposed workers, subjects with the combination of MPO G/G and XRCC1 Arg/Gln or Gln/Gln showed a significantly higher CA frequency compared to those with the combination of MPO G/A or A/A and XRCC1 Arg/Arg genotypes.	Arginine	203-206	X-ray repair cross complementing 1	Homo sapiens	197-202
18681934-3	2008	* Here, a collection of T-DNA knockout mutants were screened for alterations in Arabidopsis root uptake rates of L-Arg and it was found that only the AAP5 mutant displayed clear phenotypic divergence on high concentrations of L-Arg.	Arginine	113-118	amino acid permease 5	Arabidopsis thaliana	150-154
18681934-3	2008	* Here, a collection of T-DNA knockout mutants were screened for alterations in Arabidopsis root uptake rates of L-Arg and it was found that only the AAP5 mutant displayed clear phenotypic divergence on high concentrations of L-Arg.	Arginine	226-231	amino acid permease 5	Arabidopsis thaliana	150-154
18681934-4	2008	A second screen using low concentrations of (15)N-labelled L-Arg in the growth media also identified AAP5 as being involved in L-Arg acquisition.	Arginine	59-64	amino acid permease 5	Arabidopsis thaliana	101-105
18681934-4	2008	A second screen using low concentrations of (15)N-labelled L-Arg in the growth media also identified AAP5 as being involved in L-Arg acquisition.	Arginine	127-132	amino acid permease 5	Arabidopsis thaliana	101-105
18042685-8	2008	Using a series of mutants on the HBPE, we identified the most important amino acids involved in zymogen/Ixolaris interaction-Arg-93 &gt;&gt;&gt; Arg-165 &gt; or = Lys-169 &gt; Lys-236 &gt; Arg-125-which was identical to that observed for FXa/Ixolaris interaction.	Arginine	125-128	coagulation factor X	Homo sapiens	238-241
17913711-2	2007	In cyanobacteria and plants, PII relieves the feedback inhibition of the rate-limiting step in arginine biosynthesis catalyzed by N-acetylglutamate kinase (NAGK).	Arginine	95-103	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	130-154
17913711-2	2007	In cyanobacteria and plants, PII relieves the feedback inhibition of the rate-limiting step in arginine biosynthesis catalyzed by N-acetylglutamate kinase (NAGK).	Arginine	95-103	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	156-160
18035963-3	2007	Polymorphisms of the beta2 adrenoceptor (ADRB2), notably the variant associated with an arginine moiety at position 16 of the ADRB2 protein result in changes in in vitro receptor function.	Arginine	88-96	adrenoceptor beta 2	Homo sapiens	21-39
18035963-3	2007	Polymorphisms of the beta2 adrenoceptor (ADRB2), notably the variant associated with an arginine moiety at position 16 of the ADRB2 protein result in changes in in vitro receptor function.	Arginine	88-96	adrenoceptor beta 2	Homo sapiens	41-46
18035963-3	2007	Polymorphisms of the beta2 adrenoceptor (ADRB2), notably the variant associated with an arginine moiety at position 16 of the ADRB2 protein result in changes in in vitro receptor function.	Arginine	88-96	adrenoceptor beta 2	Homo sapiens	126-131
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Arginine	113-121	immunoglobulin binding protein 1	Homo sapiens	62-67
17953656-7	2007	Other studies have shown that replacement of these histidines alpha(1) H101, alpha(2) H101, and alpha(3) H126 by arginine, as naturally present in alpha(4) and alpha(6) , leads to benzodiazepine insensitivity of these receptors.	Arginine	113-121	immunoglobulin binding protein 1	Homo sapiens	147-154
17855160-10	2007	The DNA-repair capacity was significantly lower in individuals with variant Gln/Gln genotype in XRCC1 Arg399Gln than in those with heterozygous Arg/Gln and wild-type Arg/Arg genotypes.	Arginine	102-105	X-ray repair cross complementing 1	Homo sapiens	96-101
17726015-2	2007	Previous investigations have established that solvent-exposed, charged residues of the FXa alpha-helix 163-170 (h163-170), Arg(165) and Lys(169), participate in its binding to FVa.	Arginine	123-126	coagulation factor X	Homo sapiens	87-90
17900474-0	2007	Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes.	Arginine	13-21	tribbles pseudokinase 3	Homo sapiens	82-87
17764653-0	2007	Arginine methylation of Sam68 and SLM proteins negatively regulates their poly(U) RNA binding activity.	Arginine	0-8	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	24-29
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	KH RNA binding domain containing, signal transduction associated 2	Homo sapiens	68-73
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	85-90
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	protein arginine methyltransferase 1	Homo sapiens	229-265
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	158-161	protein arginine methyltransferase 1	Homo sapiens	267-272
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	KH RNA binding domain containing, signal transduction associated 2	Homo sapiens	68-73
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	85-90
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	protein arginine methyltransferase 1	Homo sapiens	229-265
17764653-1	2007	Sam68 (Src substrate associated during mitosis) and its homologues, SLM-1 and SLM-2 (Sam68-like mammalian proteins), are RNA binding proteins and contain the arg-gly (RG) repeats, in which arginine residues are methylated by the protein arginine methyltransferase 1 (PRMT1).	Arginine	189-197	protein arginine methyltransferase 1	Homo sapiens	267-272
17764653-5	2007	Overexpression of PRMT1 increased arginine methylation of Sam68 and SLM proteins in cells, which resulted in a decrease of their poly(U) binding ability.	Arginine	34-42	protein arginine methyltransferase 1	Homo sapiens	18-23
17764653-5	2007	Overexpression of PRMT1 increased arginine methylation of Sam68 and SLM proteins in cells, which resulted in a decrease of their poly(U) binding ability.	Arginine	34-42	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	58-63
17764653-6	2007	The results suggest that the RG repeats conserved in Sam68 and SLM proteins may function as an auxiliary RNA binding domain and arginine methylation may eliminate or reduce an RNA binding ability of the proteins.	Arginine	128-136	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	53-58
17667862-5	2007	We found a novel (R384T) heterozygous mutation in PRKAG2, affecting an arginine residue in the N-terminal AMP-binding domain.	Arginine	71-79	protein kinase AMP-activated non-catalytic subunit gamma 2	Homo sapiens	50-56
20641247-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
20641579-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
17496029-1	2007	In the cytochrome c-551 family, the heme 17-propionate caboxylate group is always hydrogen bonded to an invariant Trp-56 and conserved residues (His and Arg mainly, Lys occasionally) at position 47.	Arginine	153-156	cytochrome c3 family protein	Pseudomonas stutzeri	7-19
17925066-4	2007	Results from these studies demonstrate that patients with the Arg/Arg phenotype at the 16th amino acid position of the beta2-adrenergic receptor may experience worsening asthma outcomes after regular beta2-agonist use.	Arginine	62-65	adrenoceptor beta 2	Homo sapiens	119-144
17925066-4	2007	Results from these studies demonstrate that patients with the Arg/Arg phenotype at the 16th amino acid position of the beta2-adrenergic receptor may experience worsening asthma outcomes after regular beta2-agonist use.	Arginine	66-69	adrenoceptor beta 2	Homo sapiens	119-144
17427197-0	2007	D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium.	Arginine	25-35	erythrocyte membrane protein band 4.2	Homo sapiens	134-137
17710231-4	2007	Mapping of H193R mutation onto the crystal structure of myrosinase, a plant homolog of KL, revealed that this histidine residue was at the base of the deep catalytic cleft and mutation of this histidine to arginine should destabilize the putative glycosidase domain (KL1) of KL, thereby attenuating production of membrane-bound and secreted KL.	Arginine	206-214	KIT ligand	Homo sapiens	267-270
20641670-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
20641243-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
17604274-10	2007	Additional enzyme studies demonstrated that FucT-VI has approximately 12-fold higher activity compared with FucT-V and that the Trp(124)/Arg(110) site in these enzymes is responsible primarily for this activity difference.	Arginine	137-140	fucosyltransferase 5	Homo sapiens	44-50
17585876-4	2007	Replacement of these lysines by arginine enhanced the transcriptional activity of E1AF, suggesting that sumoylation negatively regulates E1AF activity.	Arginine	32-40	ETS variant transcription factor 4	Homo sapiens	82-86
17585876-4	2007	Replacement of these lysines by arginine enhanced the transcriptional activity of E1AF, suggesting that sumoylation negatively regulates E1AF activity.	Arginine	32-40	ETS variant transcription factor 4	Homo sapiens	137-141
20641712-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
17655495-1	2007	Recently, a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, SRA1 (SR-A1), has been discovered and cloned by members of our group, the gene for which was found to be overexpessed in a series of human tumors.	Arginine	44-47	steroid receptor RNA activator 1	Homo sapiens	96-100
17655495-1	2007	Recently, a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, SRA1 (SR-A1), has been discovered and cloned by members of our group, the gene for which was found to be overexpessed in a series of human tumors.	Arginine	44-47	steroid receptor RNA activator 1	Homo sapiens	102-107
17671141-7	2007	By mutating residue 126 from an arginine to a tyrosine, we embedded a synthetic immunogenic analogue CD8(+) epitope (126-134) inside the longer peptide (122-140).	Arginine	32-40	CD8a molecule	Homo sapiens	101-104
17540775-5	2007	Residue Arg(346) was a critical recognition element on PAI-1 for interaction with FSAP.	Arginine	8-11	hyaluronan binding protein 2	Homo sapiens	82-86
17553804-6	2007	The fully formed prothrombinase complex containing this FVa mutant had fairly normal kinetic parameters (k(cat) and K(m)) for cleavage of prothrombin at Arg-320.	Arginine	153-156	coagulation factor X	Homo sapiens	17-31
17472963-2	2007	In this study, we hypothesized that the specific interaction site for C1P was localized to the cationic beta-groove (Arg(57), Lys(58), Arg(59)) of the C2 domain of cPLA(2)alpha.	Arginine	117-120	phospholipase A2 group IVA	Homo sapiens	164-176
17472963-2	2007	In this study, we hypothesized that the specific interaction site for C1P was localized to the cationic beta-groove (Arg(57), Lys(58), Arg(59)) of the C2 domain of cPLA(2)alpha.	Arginine	135-138	phospholipase A2 group IVA	Homo sapiens	164-176
17374727-7	2007	However, at the highest tertile of arsenic, the XRCC1 194Arg/Arg polymorphism conferred a 3-fold larger odds ratio for skin lesions compared with XRCC1 194Trp/Trp.	Arginine	57-60	X-ray repair cross complementing 1	Homo sapiens	48-53
17489985-4	2007	Both ADH2 Arg/Arg and ALDH2 Glu/Lys were found to be independently associated with increased risk, with odds ratios (OR) of 2.67 (95% confidence interval [CI] 1.51-4.57) and 1.66 (95% CI 1.20-2.31), respectively.	Arginine	10-13	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	5-9
17489985-4	2007	Both ADH2 Arg/Arg and ALDH2 Glu/Lys were found to be independently associated with increased risk, with odds ratios (OR) of 2.67 (95% confidence interval [CI] 1.51-4.57) and 1.66 (95% CI 1.20-2.31), respectively.	Arginine	14-17	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	5-9
17489985-5	2007	Further, compared with subjects having both ADH2 His/His and ALDH2 Glu/Glu, the adjusted OR and its 95% CI for those with both ADH2 Arg/Arg and ALDH2 Glu/Lys was 5.00 (2.32-10.71) in all subjects.	Arginine	132-135	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	127-131
17525731-5	2007	Alternatively, we found that arginine 314 (Arg314) in the CREB basic-leucine zipper (bZIP) domain contributed to CBP/p300 recruitment and KIX-independent CREB transactivation function.	Arginine	29-37	cAMP responsive element binding protein 1	Homo sapiens	58-62
17525731-5	2007	Alternatively, we found that arginine 314 (Arg314) in the CREB basic-leucine zipper (bZIP) domain contributed to CBP/p300 recruitment and KIX-independent CREB transactivation function.	Arginine	29-37	cAMP responsive element binding protein 1	Homo sapiens	154-158
17347382-2	2007	Previous research has suggested that subjects homozygous for arginine at amino acid 16 of the beta2AR (Arg16) may have attenuated receptor function relative to subjects homozygous for glycine at the same amino acid (Gly16).	Arginine	61-69	adrenoceptor beta 2	Homo sapiens	94-101
17347382-8	2007	These data suggest that subjects homozygous for Arg at amino acid 16 of the beta2AR have a greater susceptibility for lung fluid accumulation relative to subjects homozygous for Gly at this position.	Arginine	48-51	adrenoceptor beta 2	Homo sapiens	76-83
17508782-5	2007	In particular, the register of these amino acids holds Asn-25 that is critical for the virus binding with primary cell receptor CD4 as well as Arg-3 that is critical for utilization of CCR5 co-receptor and heparan sulfate proteoglycans.	Arginine	143-146	C-C motif chemokine receptor 5	Homo sapiens	185-189
17171640-5	2007	Here, we examined prosaposin as an ARG.	Arginine	35-38	prosaposin	Homo sapiens	18-28
17171640-8	2007	Our data for the first time identify prosaposin as an ARG.	Arginine	54-57	prosaposin	Homo sapiens	37-47
17513437-2	2007	Citrulline formed as a by-product of the NOS reaction can be recycled to arginine by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL).	Arginine	73-81	argininosuccinate lyase	Homo sapiens	123-146
17450127-7	2007	The ADP-ribosylation of GRP7 by HopU1 required two arginines within the RRM, indicating that this modification may interfere with GRP7"s ability to bind RNA.	Arginine	51-60	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	24-28
17450127-7	2007	The ADP-ribosylation of GRP7 by HopU1 required two arginines within the RRM, indicating that this modification may interfere with GRP7"s ability to bind RNA.	Arginine	51-60	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	130-134
17296339-8	2007	The present DDAH activity assay allows for the first time to simultaneously determine DDAH activity and endogenous formation of ADMA, SDMA, and L-arginine in tissue.	Arginine	144-154	dimethylarginine dimethylaminohydrolase 2	Mus musculus	12-16
17456547-4	2007	Here, we identify a surface-exposed conserved arginine residue at position 30 (R30), which is crucial for coronin 1B binding to F-actin both in vitro and in vivo.	Arginine	46-54	coronin 1B	Homo sapiens	106-116
17417874-6	2007	Activation of pro-KLK6 requires hydrolysis after a Lys residue; however, KLK6 exhibits 2 order of magnitude reduced affinity for hydrolysis after Lys versus Arg residues; therefore, the ability to autolytically activate has been called into question.	Arginine	157-160	kallikrein related peptidase 6	Homo sapiens	73-77
17417879-0	2007	Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D.	Arginine	17-20	surfactant protein D	Homo sapiens	102-122
17355263-6	2007	We found that individuals with the Arg/Gln and Arg/Gln + Gln/Gln genotypes at XRCC1 Arg399Gln(G &gt; A) had an approximately 2-fold increased risk of basal cell carcinoma compared to individuals with the Arg/Arg genotype (adjusted odds ratio [AOR] = 2.812, 95% confidence interval [CI] 1.32-5.98, and AOR = 2.324, 95% CI 1.11-4.86).	Arginine	35-38	X-ray repair cross complementing 1	Homo sapiens	78-83
17355263-6	2007	We found that individuals with the Arg/Gln and Arg/Gln + Gln/Gln genotypes at XRCC1 Arg399Gln(G &gt; A) had an approximately 2-fold increased risk of basal cell carcinoma compared to individuals with the Arg/Arg genotype (adjusted odds ratio [AOR] = 2.812, 95% confidence interval [CI] 1.32-5.98, and AOR = 2.324, 95% CI 1.11-4.86).	Arginine	47-50	X-ray repair cross complementing 1	Homo sapiens	78-83
17355263-6	2007	We found that individuals with the Arg/Gln and Arg/Gln + Gln/Gln genotypes at XRCC1 Arg399Gln(G &gt; A) had an approximately 2-fold increased risk of basal cell carcinoma compared to individuals with the Arg/Arg genotype (adjusted odds ratio [AOR] = 2.812, 95% confidence interval [CI] 1.32-5.98, and AOR = 2.324, 95% CI 1.11-4.86).	Arginine	47-50	X-ray repair cross complementing 1	Homo sapiens	78-83
17355263-6	2007	We found that individuals with the Arg/Gln and Arg/Gln + Gln/Gln genotypes at XRCC1 Arg399Gln(G &gt; A) had an approximately 2-fold increased risk of basal cell carcinoma compared to individuals with the Arg/Arg genotype (adjusted odds ratio [AOR] = 2.812, 95% confidence interval [CI] 1.32-5.98, and AOR = 2.324, 95% CI 1.11-4.86).	Arginine	47-50	X-ray repair cross complementing 1	Homo sapiens	78-83
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Arginine	40-48	regulating synaptic membrane exocytosis 1	Homo sapiens	115-120
18690027-4	2007	We demonstrate here that the mouse RIM1 arginine-to-histidine substitution (R655H), which corresponds to the human CORD7 mutation, modifies RIM1 function in regulating VDCC currents elicited by the P/Q-type Ca(v)2.1 and L-type Ca(v)1.4 channels.	Arginine	40-48	regulating synaptic membrane exocytosis 1	Homo sapiens	140-144
17310064-5	2007	Indeed, the loss of function resulting from the mutation of the conserved lysine residue into aspartate or glutamate in the TM3 of gamma-aminobutyric acid type B(2) can be partly rescued by mutating the conserved acidic residue of TM6 into either lysine or arginine.	Arginine	257-265	tropomyosin 3	Homo sapiens	124-127
17425781-1	2007	BACKGROUND: In microorganisms and plants, the first two reactions of arginine biosynthesis are catalyzed by N-acetylglutamate synthase (NAGS) and N-acetylglutamate kinase (NAGK).	Arginine	69-77	N-acetylglutamate synthase	Homo sapiens	108-134
17425781-1	2007	BACKGROUND: In microorganisms and plants, the first two reactions of arginine biosynthesis are catalyzed by N-acetylglutamate synthase (NAGS) and N-acetylglutamate kinase (NAGK).	Arginine	69-77	N-acetylglutamate synthase	Homo sapiens	136-140
17287211-10	2007	We propose that the anti/syn conversion can only induce a fast reorientation and distance change of the Schiff base but fails to build up the full set of dark ground state constraints, presumably involving the Glu(134)/Arg(135) cluster.	Arginine	219-222	synemin	Homo sapiens	25-28
17420372-1	2007	OBJECTIVES: To determine the role of systemic complement activation in the pathogenesis of age-related macular degeneration and to examine whether serum C3a des Arg reflects systemic complement activation, independent of individual complement component levels.	Arginine	161-164	complement C3	Homo sapiens	153-156
17420372-3	2007	RESULTS: The median (range) of plasma complement C3a des Arg levels in the age-related maculopathy and neovascular age-related macular degeneration groups were 52.6 (2.8-198.1) ng/mL and 60.9 (3.1-173.1) ng/mL, respectively.	Arginine	57-60	complement C3	Homo sapiens	49-52
17420372-4	2007	The levels were significantly raised compared with the control group (n = 38), which had a median (range) plasma complement C3a des Arg level of 40.3 (6.1-81.7) ng/mL (analysis of variance, P = .02).	Arginine	132-135	complement C3	Homo sapiens	124-127
17696747-6	2007	The XRCC1 genotype frequencies revealed 36% Arg/Arg, 47% Arg/Gln and 17% Gln/Gln with Gln allele frequency of 0.41.	Arginine	44-47	X-ray repair cross complementing 1	Homo sapiens	4-9
17696747-6	2007	The XRCC1 genotype frequencies revealed 36% Arg/Arg, 47% Arg/Gln and 17% Gln/Gln with Gln allele frequency of 0.41.	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	4-9
17696747-6	2007	The XRCC1 genotype frequencies revealed 36% Arg/Arg, 47% Arg/Gln and 17% Gln/Gln with Gln allele frequency of 0.41.	Arginine	48-51	X-ray repair cross complementing 1	Homo sapiens	4-9
17375198-3	2007	MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val(5) and Lys(79)-Arg(80).	Arginine	75-78	matrix metallopeptidase 8	Mus musculus	0-5
17375198-9	2007	MMP-8 cleaves CXCL8 at Arg(5)-Ser(6) and at Val(7)-Leu(8) in CXCL5 to activate respective chemokines.	Arginine	23-26	matrix metallopeptidase 8	Mus musculus	0-5
17112341-7	2007	Changing Trp-479, Iso-490, Arg-505, Leu-511 or Asp-512 was predicted, based on previous studies, to affect affinity for Arf1-GTP.	Arginine	27-30	ADP ribosylation factor 1	Homo sapiens	120-124
17385170-8	2007	Patients with creatine transporter deficiency are being treated with arginine, because a lack of response to creatine.	Arginine	69-77	solute carrier family 6 member 8	Homo sapiens	14-34
17353334-5	2007	Three patients with arginine:glycine amidinotransferase defect (AGAT-d) were treated with different Cr intakes.	Arginine	20-28	glycine amidinotransferase	Homo sapiens	64-68
17427647-10	2007	Genetic analysis identified a change from Arg (CGT) at codon 201 to Cys (TGT).	Arginine	42-45	UDP glycosyltransferase 8	Homo sapiens	47-50
17241698-6	2007	Strong tyrosinase-binding peptides always contain one or more arginine residues, often in combination with phenylalanine, while lysine residues can be found equally among nonbinding peptides as well as moderate tyrosinase-binding peptides.	Arginine	62-70	tyrosinase	Homo sapiens	7-17
17241698-8	2007	Therefore, good tyrosinase inhibitory peptides preferably contain arginine and/or phenylalanine in combination with valine, alanine and/or leucine.	Arginine	66-74	tyrosinase	Homo sapiens	16-26
17264152-0	2007	hCAF1, a new regulator of PRMT1-dependent arginine methylation.	Arginine	42-50	protein arginine methyltransferase 1	Homo sapiens	26-31
17158453-0	2007	A C-helix residue, Arg-123, has important roles in both the active and inactive forms of the cAMP receptor protein.	Arginine	19-22	catabolite gene activator protein	Escherichia coli	93-114
17158453-3	2007	Here we show that another C-helix residue, Arg-123, has a unique role in cAMP-dependent CRP activation in two different ways.	Arginine	43-46	catabolite gene activator protein	Escherichia coli	88-91
17158453-5	2007	Second, Arg-123 is optimal for stabilizing the inactive conformation of CRP when cAMP is absent, thereby allowing a maximal range of regulation by cAMP.	Arginine	8-11	catabolite gene activator protein	Escherichia coli	72-75
17098364-6	2007	These compounds inhibited the L-citrulline formation of nNOS from L-arginine, and the inhibitory effects were abrogated by raising the concentration of calmodulin.	Arginine	66-76	nitric oxide synthase 1	Rattus norvegicus	56-60
17203224-3	2007	We searched for genes related to ESCC, and identified a novel gene, FLJ11021, which was designated arginine/serine-rich coiled-coil 2 (RSRC2).	Arginine	99-107	arginine and serine rich coiled-coil 2	Homo sapiens	135-140
17222963-6	2007	We can attenuate the directional preferences for human 17betaHSD type 1 and rat AKR1C9 in intact cells by either diminishing the NADPH/NADP(+) gradient or by mutating the arginine residues that form salt bridges with the 2"-phosphate of NADP(H) (R38 and R276, respectively).	Arginine	171-179	aldo-keto reductase family 1, member C14	Rattus norvegicus	80-86
17031564-4	2007	The conversion of arginine to citrulline in brain is carried out by an enzyme peptidyl arginine deiminase (PAD) 2.	Arginine	18-26	peptidyl arginine deiminase 2	Homo sapiens	78-113
17166537-7	2007	Crystal structure of the extracellular segment of integrin alphavbeta3 in complexing with an Arg-Gly-Asp ligand.	Arginine	93-96	integrin subunit alpha V	Homo sapiens	50-70
17268153-4	2007	This review introduces our approaches that employ an Arg-Gly-Asp (RGD) fiber-mutant adenovirus vector encoding the chemokine or chemokine receptor gene in cancer immunotherapy.	Arginine	53-56	C-X-C motif chemokine receptor 4	Homo sapiens	128-146
17071614-8	2007	In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)).	Arginine	226-229	C-C motif chemokine receptor 6	Homo sapiens	43-47
17234578-3	2007	We show that NMDA receptor activation markedly reduces arginine transport by decreasing surface expression of the cationic amino acid transporters (CAT) 1 and 3.	Arginine	55-63	solute carrier family 7 member 1	Homo sapiens	148-160
17255300-7	2007	The increased arginase activity was limited to the CD11b(+)CD14(-) myeloid cells and resulted in significantly decreased serum levels of arginine and increased ornithine in patients.	Arginine	137-145	integrin subunit alpha M	Homo sapiens	51-56
17198398-4	2007	Ime2 protein kinase assays with Sum1 mutants and synthetic peptides define a consensus Arg-Pro-X-Ser/Thr motif that is required for efficient phosphorylation by Ime2.	Arginine	87-90	Sum1p	Saccharomyces cerevisiae S288C	32-36
16978906-0	2007	Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity.	Arginine	45-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	8-27
17101795-3	2007	Here, we found that myocardin"s activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation.	Arginine	187-195	myocardin	Homo sapiens	20-29
17101795-3	2007	Here, we found that myocardin"s activity was strongly enhanced by SUMO-1 via modification of a lysine residue primarily located at position 445 and that the conversion of this residue to arginine (K445R) impaired myocardin transactivation.	Arginine	187-195	myocardin	Homo sapiens	213-222
17374341-3	2007	In 597 patients treated by a beta-blocker and followed for 3 years after a myocardial infarction or an acute coronary syndrome, the death rate was 5.4 times higher in homozygous Arg 16 and Gln 27 B2AR genotypes than in heterozygous or homozygous Gly 16 and Glu 27 B2AR genotypes.	Arginine	178-181	adrenoceptor beta 2	Homo sapiens	264-268
16989961-5	2006	Our results show that the synonymous codon usage for Arg (through the AGG, AGA and CGT codons) is the most discriminating factor between (hyper)thermophilic and non-thermophilic species, thus confirming previous studies.	Arginine	53-56	UDP glycosyltransferase 8	Homo sapiens	83-86
17097055-4	2006	Substitution of the target lysine to arginine lost the sumoylation but little affected transcriptional potential or nuclear localization of Sox2.	Arginine	37-45	SRY (sex determining region Y)-box 2	Mus musculus	140-144
17068344-3	2006	C3a and C3a-des-Arg(77), also called acylation-stimulating protein, augment triglyceride synthesis and glucose uptake in adipocytes and skin fibroblasts.	Arginine	16-19	complement C3	Homo sapiens	8-11
17028019-2	2006	We demonstrated previously that two type II metacaspases of Arabidopsis thaliana, AtMC4 and AtMC9 are Arg/Lys-specific cysteine-dependent proteases.	Arginine	102-105	metacaspase 4	Arabidopsis thaliana	82-87
17078101-5	2006	We found that among GSTT1(+) individuals the DEB-induced SCE level was significantly lower when the EPHX 139 codon was His/Arg rather than His/His.	Arginine	123-126	glutathione S-transferase theta 1	Homo sapiens	20-25
16998217-6	2006	CONCLUSIONS: In rat mesangial cells, peroxynitrite augments arginine uptake via augmentation of CAT-2 while decreasing CAT-1 expression.	Arginine	60-68	solute carrier family 7 member 2	Rattus norvegicus	96-101
17097032-8	2006	With a C-G transversion in nucleotide 13,619 of the MYH7 gene, located at the essential light chain interacting region in S1, the replacement of arginine by glycine took place at amino acid residue 723.	Arginine	145-153	myosin heavy chain 7	Homo sapiens	52-56
16989765-9	2006	Bioinformatic analyses indicate that histidine 158 is an evolutionarily conserved residue in most vertebrate TIMP homologs and predict that substitution by arginine disrupts TIMP3 function.	Arginine	156-164	TIMP metallopeptidase inhibitor 3	Homo sapiens	174-179
17099033-4	2006	METHODS: We studied baseline PF according to genetic variations of the ADRB2 at amino acid 16 (ie, arginine [Arg] or glycine [Gly]) in 126 CHF patients (mean [+/- SEM] age, 56 +/- 1 years; left ventricular ejection fraction [LVEF], 29 +/- 1%; body mass index [BMI], 28 +/- 0.4 kg/m2) and in 100 healthy control subjects (mean age, 50 +/- 2 years; LVEF, 63 +/- 0.7%; BMI, 25 +/- 0.3 kg/m2).	Arginine	99-107	adrenoceptor beta 2	Homo sapiens	71-76
17099033-4	2006	METHODS: We studied baseline PF according to genetic variations of the ADRB2 at amino acid 16 (ie, arginine [Arg] or glycine [Gly]) in 126 CHF patients (mean [+/- SEM] age, 56 +/- 1 years; left ventricular ejection fraction [LVEF], 29 +/- 1%; body mass index [BMI], 28 +/- 0.4 kg/m2) and in 100 healthy control subjects (mean age, 50 +/- 2 years; LVEF, 63 +/- 0.7%; BMI, 25 +/- 0.3 kg/m2).	Arginine	109-112	adrenoceptor beta 2	Homo sapiens	71-76
17099033-8	2006	CONCLUSIONS: These data suggest that genetic variation of the ADRB2 is associated with differences in PF in CHF patients but not in healthy subjects, which may be related to an increased susceptibility of the homozygous Arg subjects to agonist-mediated desensitization of ADRB2s in the lungs, or related to an influence of this polymorphism on cardiac diastolic properties.	Arginine	220-223	adrenoceptor beta 2	Homo sapiens	62-67
17099033-8	2006	CONCLUSIONS: These data suggest that genetic variation of the ADRB2 is associated with differences in PF in CHF patients but not in healthy subjects, which may be related to an increased susceptibility of the homozygous Arg subjects to agonist-mediated desensitization of ADRB2s in the lungs, or related to an influence of this polymorphism on cardiac diastolic properties.	Arginine	220-223	adrenoceptor beta 2	Homo sapiens	272-277
16923966-4	2006	Methylation of SRC-3 was localized to an arginine in its CARM1 binding region and correlated with decreased estrogen receptor alpha-mediated transcription, as seen with both cell-based and in vitro transcription assays.	Arginine	41-49	coactivator associated arginine methyltransferase 1	Homo sapiens	57-62
16772309-1	2006	BACKGROUND: The homozygous presence of the arginine-16 variant of the beta(2) adrenoceptor gene ADRB2 reverses the benefits from the regular use of short acting beta(2) agonists in asthmatic adults compared with the homozygous glycine-16 genotype.	Arginine	43-51	adrenoceptor beta 2	Homo sapiens	70-90
16772309-1	2006	BACKGROUND: The homozygous presence of the arginine-16 variant of the beta(2) adrenoceptor gene ADRB2 reverses the benefits from the regular use of short acting beta(2) agonists in asthmatic adults compared with the homozygous glycine-16 genotype.	Arginine	43-51	adrenoceptor beta 2	Homo sapiens	96-101
16772309-7	2006	CONCLUSIONS: The arginine-16 genotype of ADRB2 predisposes to exacerbations in asthmatic children and young adults, particularly in those exposed to regular salmeterol.	Arginine	17-25	adrenoceptor beta 2	Homo sapiens	41-46
16899465-5	2006	We have demonstrated that Abl-dependent phosphorylation of WAVE2 is necessary for its activation in vivo, which is highlighted by the findings that RNA interference of WAVE2 expression in Abl/Arg-/- cells has no additive effect on the amount of membrane ruffling.	Arginine	192-195	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	26-29
16935856-2	2006	The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa).	Arginine	16-19	coagulation factor X	Homo sapiens	64-73
16935856-2	2006	The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa).	Arginine	16-19	coagulation factor X	Homo sapiens	75-78
17052457-5	2006	Second, PRMT1 is recruited to the HNF4 ligand-binding domain (LBD) through a mechanism that involves the p160 family of coactivators and methylates histone H4 at arginine 3.	Arginine	162-170	protein arginine methyltransferase 1	Homo sapiens	8-13
16951376-7	2006	We have identified three charged amino acids (arginine 480, lysine 481, and arginine 486) which are essential in the binding of alpha-actinins to the ICAM-1 cytoplasmic tail.	Arginine	46-54	intercellular adhesion molecule 1	Cricetulus griseus	150-156
16951376-7	2006	We have identified three charged amino acids (arginine 480, lysine 481, and arginine 486) which are essential in the binding of alpha-actinins to the ICAM-1 cytoplasmic tail.	Arginine	76-84	intercellular adhesion molecule 1	Cricetulus griseus	150-156
16616057-2	2006	Because CPN can cleave the C-terminal arginine of C3a, C4a and C5a it is often referred to as anaphylatoxin inactivator.	Arginine	38-46	complement C3	Homo sapiens	50-53
16616057-2	2006	Because CPN can cleave the C-terminal arginine of C3a, C4a and C5a it is often referred to as anaphylatoxin inactivator.	Arginine	38-46	carboxypeptidase N subunit 1	Homo sapiens	94-119
16740631-8	2006	In contrast, hK4, hK5, and less stringent hK6 displayed a trypsin-like specificity with strong preference for P1-Arg, whereas hK10 and hK11 showed an ambivalent specificity, accepting both basic and large aliphatic P1 residues.	Arginine	113-116	keratin 4	Homo sapiens	13-16
16740631-8	2006	In contrast, hK4, hK5, and less stringent hK6 displayed a trypsin-like specificity with strong preference for P1-Arg, whereas hK10 and hK11 showed an ambivalent specificity, accepting both basic and large aliphatic P1 residues.	Arginine	113-116	kallikrein related peptidase 6	Homo sapiens	42-45
17009846-1	2006	Integrin alphavbeta3 plays a significant role in tumor angiogenesis and is a receptor for the extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide sequence.	Arginine	141-149	integrin subunit alpha V	Homo sapiens	0-20
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Arginine	40-48	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	73-78
16760474-9	2006	Site-directed mutagenesis revealed that Arg-118, which corresponds to Lys-120 of variola virus complement regulator SPICE (a residue critical for its enhanced C3b cofactor activity), contributes significantly in enhancing this activity.	Arginine	40-43	complement C3	Homo sapiens	159-162
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	0-8	eukaryotic translation initiation factor 2A	Rattus norvegicus	290-299
16574987-6	2006	Arginine treatment induced rapid and severe pancreatitis, as indicated by increased serum amylase, pancreatic tissue edema, and acinar cell damage within 4 h. Arginine treatment also caused an early activation of ER stress, as indicated by phosphorylation of PERK and its downstream target eIF2alpha, ATF6 translocation into the nucleus (within 1 h), and upregulation of BiP (within 4 h).	Arginine	159-167	eukaryotic translation initiation factor 2A	Rattus norvegicus	290-299
16923137-4	2006	The case 1 and 2 patients and their fathers revealed a heterozygous nucleotide G to A transition at position 6109 and 6082 in 73 exon of COL7A1, which resulted in a glycine to arginine substitution (G2037R and G2028R), respectively.	Arginine	176-184	collagen type VII alpha 1 chain	Homo sapiens	137-143
16923367-12	2006	Low or high dose L-arginine treatment increased significantly the IGF-I levels from 0.789 +/- 0.062 ng/mg (Model group) to 0.937 +/- 0.067 ng/mg (low dose group) or 0.858 +/- 0.077 ng/mg (high dose group), the IGF-II levels from 0.270 +/- 0.020 ng/mg (Model group) to 0.318 +/- 0.018 ng/mg (low dose group) or 0.354 +/- 0.021 ng/mg (high dose group) and the IGF-I mRNA expression from (13.12 +/- 1.39) x 10(4) cps/mug RNA (Model group) to (19.24 +/- 2.48) x 10(4) cps/mug RNA (low dose group) or (17.35 +/- 2.30) x 10(4) cps/mug RNA (high dose group) (P &lt; 0.01).	Arginine	17-27	insulin-like growth factor 2	Rattus norvegicus	210-216
16923367-14	2006	CONCLUSIONS: L-arginine can increase the levels of IGF-I and IGF-II and the IGF-I mRNA expression, and decrease the IGFBP3 level in the brain of rats with IUGR induced by passive smoking, thereby offering protective effects against IUGR.	Arginine	13-23	insulin-like growth factor 2	Rattus norvegicus	61-67
16809279-2	2006	Alteration of arginine 332 in the TRIM5alpha(hu) B30.2 domain to proline, the residue found in rhesus monkey TRIM5alpha, has been shown to create a potent restricting factor for both HIV-1 and SIV(mac.)	Arginine	14-22	tripartite motif containing 5	Macaca mulatta	34-44
16809279-2	2006	Alteration of arginine 332 in the TRIM5alpha(hu) B30.2 domain to proline, the residue found in rhesus monkey TRIM5alpha, has been shown to create a potent restricting factor for both HIV-1 and SIV(mac.)	Arginine	14-22	tripartite motif containing 5	Macaca mulatta	109-119
16497732-1	2006	Coactivator-associated arginine methyltransferase-1 (CARM1) is known to enhance transcriptional activation by nuclear receptors through interactions with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17).	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
16845912-2	2006	L-arginine transport mediated by the isozymes of type-2 cationic amino acid transporter (including CAT-2 and CAT-2B) has been reported to play a crucial role in regulating iNOS activity.	Arginine	0-10	dominant cataract 2	Mus musculus	99-104
16723463-2	2006	Peptidyl arginine deiminase 2 (PAD2), an enzyme that converts protein arginine to citrulline, was found only in POAG optic nerve and was probed further for a mechanistic role in glaucoma.	Arginine	9-17	peptidyl arginine deiminase 2	Homo sapiens	31-35
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Arginine	166-169	Sld2p	Saccharomyces cerevisiae S288C	4-8
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Arginine	175-178	Sld2p	Saccharomyces cerevisiae S288C	4-8
16619031-3	2006	The Sld2 protein has a cluster of 11 cyclin-dependent kinase (CDK) phosphorylation motifs (Ser/Thr-Pro), six of which match the canonical sequences Ser/Thr-Pro-X-Lys/Arg, Lys/Arg-Ser/Thr-Pro and Ser/Thr-Pro-Lys/Arg.	Arginine	175-178	Sld2p	Saccharomyces cerevisiae S288C	4-8
16371438-0	2006	Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.	Arginine	59-69	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-48
16371438-0	2006	Granulocyte-macrophage colony-stimulating factor increases L-arginine transport through the induction of CAT2 in bone marrow-derived macrophages.	Arginine	59-69	dominant cataract 2	Mus musculus	105-109
16371438-4	2006	The granulocyte macrophage colony-stimulating factor (GM-CSF), in addition to inducing proliferation and differentiation of macrophages, activates arginase I, but its action on L-arginine transport is unknown.	Arginine	177-187	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	4-52
16371438-4	2006	The granulocyte macrophage colony-stimulating factor (GM-CSF), in addition to inducing proliferation and differentiation of macrophages, activates arginase I, but its action on L-arginine transport is unknown.	Arginine	177-187	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	54-60
16332725-8	2006	The impact of ALDH2 Lys+ with ADH2 Arg+ was more evident in low folate consumer (OR = 2.32, 1.19-4.55) than high folate consumer (OR 1.38, 0.80-2.38).	Arginine	35-38	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	30-34
16651431-4	2006	Here, we show that hTra2-beta1, a member of the extended family of serine/arginine-rich (SR) splicing factors, enhances the in vivo inclusion of CD44 exons v4 and v5.	Arginine	74-82	CD44 molecule (Indian blood group)	Homo sapiens	145-149
16484215-4	2006	The function of HSP47 relies on its specific interaction with correctly folded triple-helical regions comprised of Gly-Xaa-Yaa repeats, and Arg residues at Yaa positions have been shown to be important for this interaction.	Arginine	140-143	serpin family H member 1	Homo sapiens	16-21
16484215-5	2006	The amino acid at the Yaa position (Yaa(-3)) in the N-terminal-adjoining triplet containing the critical Arg (defined as Arg(0)) was also suggested to be directly recognized by HSP47 (Koide, T., Asada, S., Takahara, Y., Nishikawa, Y., Nagata, K., and Kitagawa, K. (2006) J. Biol.	Arginine	105-108	serpin family H member 1	Homo sapiens	177-182
16484215-5	2006	The amino acid at the Yaa position (Yaa(-3)) in the N-terminal-adjoining triplet containing the critical Arg (defined as Arg(0)) was also suggested to be directly recognized by HSP47 (Koide, T., Asada, S., Takahara, Y., Nishikawa, Y., Nagata, K., and Kitagawa, K. (2006) J. Biol.	Arginine	121-124	serpin family H member 1	Homo sapiens	177-182
16484215-12	2006	The results revealed that HSP47 recognizes the Yaa(-3) and Arg(0) residues only when they are on the same peptide strand.	Arginine	59-62	serpin family H member 1	Homo sapiens	26-31
16257923-0	2006	Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel.	Arginine	78-86	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	26-36
16257923-8	2006	On the other hand, PPAR-gamma was significantly increased by glutamine but decreased by arginine, whereas heat shock proteins were similarly increased in all experimental groups.	Arginine	88-96	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	19-29
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Arginine	126-129	X-ray repair cross complementing 1	Homo sapiens	110-115
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Arginine	130-133	X-ray repair cross complementing 1	Homo sapiens	110-115
16510609-6	2006	In the CBCS, positive associations were observed between breast cancer and smoking dose for participants with XRCC1 codon 194 Arg/Arg (P(trend) = 0.046), 399 Arg/Arg (P(trend) = 0.012), and 280 His/His or His/Arg (P(trend) = 0.047) genotypes.	Arginine	130-133	X-ray repair cross complementing 1	Homo sapiens	110-115
16567399-5	2006	On the other hand, a mutant chicken Src, in which the His-122 residue is replaced by Arg, showed decreased recognition by mAb327.	Arginine	85-88	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	36-39
16411020-1	2006	The oxygenase domain of the inducible nitric oxide synthase, Delta65 iNOSox is a dimer that binds heme, L-Arginine (L-Arg), and tetrahydrobiopterin (H(4)B) and is the site for NO synthesis.	Arginine	104-114	H4 clustered histone 4	Homo sapiens	149-154
16411020-1	2006	The oxygenase domain of the inducible nitric oxide synthase, Delta65 iNOSox is a dimer that binds heme, L-Arginine (L-Arg), and tetrahydrobiopterin (H(4)B) and is the site for NO synthesis.	Arginine	104-109	H4 clustered histone 4	Homo sapiens	149-154
16210335-0	2006	L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes.	Arginine	0-10	solute carrier family 7 member 1	Homo sapiens	54-58
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Arginine	122-132	solute carrier family 7 member 1	Homo sapiens	63-96
16210335-1	2006	In the present study, we examined the role in hematopoiesis of cationic amino acid transporter 1 (CAT1), which transports L-arginine, L-lysine, L-ornithine, and L-histidine.	Arginine	122-132	solute carrier family 7 member 1	Homo sapiens	98-102
16210335-7	2006	These findings indicate that hCAT1 is involved in erythroid hematopoiesis through its role in importing L-arginine, which appears to be essential for the differentiation of red blood cells.	Arginine	104-114	solute carrier family 7 member 1	Homo sapiens	29-34
16326708-3	2006	Recent advances in studies on the binding specificity of HSP47 have revealed that Arg residues at Yaa positions in collagenous Gly-Xaa-Yaa repeats are critical for its interactions (Koide, T., Takahara, Y., Asada, S., and Nagata, K. (2002) J. Biol.	Arginine	82-85	serpin family H member 1	Homo sapiens	57-62
16326708-11	2006	Second, a binding study using heterotrimeric model clients for HSP47 demonstrated a minimal requirement for the number of Arg residues in the triple helix.	Arginine	122-125	serpin family H member 1	Homo sapiens	63-68
16326711-3	2006	GTA and GTB differ in only four "critical" amino acid residues (Arg/Gly-176, Gly/Ser-235, Leu/Met-266, and Gly/Ala-268).	Arginine	64-67	integrin subunit alpha 2b	Homo sapiens	0-3
16455491-4	2006	The conformation of the proline, acting through an invariant arginine as relay, determines and stabilizes the opened and closed conformation of the substrate binding domain and thereby regulates the chaperone activity of Hsp70.	Arginine	61-69	heat shock protein family A (Hsp70) member 4	Homo sapiens	221-226
16415880-1	2006	Bacterial tRNA adenosine deaminases (TadAs) catalyze the hydrolytic deamination of adenosine to inosine at the wobble position of tRNA(Arg2), a process that enables this single tRNA to recognize three different arginine codons in mRNA.	Arginine	211-219	AT695_RS00230	Staphylococcus aureus	130-139
16413071-1	2006	Most classical phosphotyrosyl phosphatases (PTPs), including the Src homology phosphotyrosyl phosphatase 2 (SHP2) possess a Thr or a Ser residue immediately C-terminal to the invariant Arg in the active site consensus motif (H/V-C-X5-R-S/T), also known as the "signature motif".	Arginine	185-188	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	65-106
16413071-1	2006	Most classical phosphotyrosyl phosphatases (PTPs), including the Src homology phosphotyrosyl phosphatase 2 (SHP2) possess a Thr or a Ser residue immediately C-terminal to the invariant Arg in the active site consensus motif (H/V-C-X5-R-S/T), also known as the "signature motif".	Arginine	185-188	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	108-112
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Arginine	140-148	coagulation factor X	Homo sapiens	10-19
16454727-4	2006	Thrombin, factor Xa, tissue factor/factor VIIa and platelet GPIIb/IIIa receptors display a preference for molecules containing highly basic arginine and/or acidic aspartate moieties, which are, however, associated with poor bioavailability after oral application.	Arginine	140-148	integrin subunit alpha 2b	Homo sapiens	60-65
16344367-7	2006	VEGF-induced ROS production was even further increased by the addition of extra L-arginine.	Arginine	80-90	vascular endothelial growth factor A	Mus musculus	0-4
16352570-8	2006	A mutagenesis study showed that the arginine residue in the PPRY motif is responsible for the low activity of the NS3 late-domain motifs.	Arginine	36-44	KRAS proto-oncogene, GTPase	Homo sapiens	114-117
16444720-0	2006	Heme oxygenase 1 expression in postischemic reperfusion liver damage: effect of L-arginine.	Arginine	80-90	heme oxygenase 1	Rattus norvegicus	0-16
16444720-7	2006	Treatment with L-arginine increased the expression of HO-1.	Arginine	15-25	heme oxygenase 1	Rattus norvegicus	54-58
16337200-3	2005	hK8 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Arginine	59-62	keratin 8	Homo sapiens	0-3
16289022-3	2005	The proprotein convertases, furin, PACE4, and PC5/6 efficiently removed the prodomain through cleavage at Arg(212)/Phe(213), generating an active enzyme.	Arginine	106-109	proprotein convertase subtilisin/kexin type 6	Homo sapiens	35-40
16294045-0	2005	The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity.	Arginine	26-34	protein arginine methyltransferase 1	Homo sapiens	49-54
16294045-3	2005	Herein, we show that the GAR motif of 53BP1 is arginine methylated by protein arginine methyltransferase 1 (PRMT1), the same methyltransferase that methylates MRE11.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	70-106
16294045-3	2005	Herein, we show that the GAR motif of 53BP1 is arginine methylated by protein arginine methyltransferase 1 (PRMT1), the same methyltransferase that methylates MRE11.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	108-113
16294047-5	2005	We demonstrate that arginine residues within this region are important for asymmetric methylation by the PRMT1 methyltransferase.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	105-110
16198009-12	2005	The strong conservation of PRMT1 homologs between protozoa and humans highlights the importance of arginine methylation as a regulatory mechanism in eukaryotes.	Arginine	99-107	protein arginine methyltransferase 1	Homo sapiens	27-32
16095636-0	2005	Design, synthesis, and evaluation of the antipsychotic potential of orally bioavailable neurotensin (8-13) analogues containing non-natural arginine and lysine residues.	Arginine	140-148	neurotensin	Rattus norvegicus	88-99
16272429-4	2005	Isolated mitochondria from leaves of wild-type plants supported Arg-stimulated NO synthesis that could be inhibited by NOS inhibitors and quenched by a NO scavenger; this NOS activity is absent in mitochondria isolated from nos1 mutant plants.	Arginine	64-67	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	224-228
16055159-7	2005	Furthermore, in arginine deficient media, env-fs frameshifting increased over 100% (p&lt;0.005), consistent with the hypothesized hungry codon mechanism.	Arginine	16-24	endogenous retrovirus group K member 20	Homo sapiens	42-45
16159886-1	2005	Arginine methylation is a posttranslational protein modification catalyzed by a family of protein arginine methyltransferases (PRMT), the predominant member of which is PRMT1.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	169-174
16270151-6	2005	All isoforms of BmTRA-2 protein contain two arginine/serine-rich domains and one RNA recognition motif, showing striking organizational similarity to Drosophila TRA-2 proteins.	Arginine	44-52	transformer 2	Drosophila melanogaster	18-23
16304337-1	2005	STUDY OBJECTIVES: To evaluate the effects of L-arginine on acute pulmonary embolism (APE)-induced pulmonary hypertension and increases in lung matrix metalloproteinase (MMP)-2 and MMP-9 activities.	Arginine	45-55	matrix metallopeptidase 9	Rattus norvegicus	180-185
16304337-10	2005	While L-arginine at 0.5 mmol/L produced no effect on MMPs, L-arginine 3 at mmol/L and 10 mmol/L attenuated the increases in MMP-2 and MMP-9 activities after APE (both p &lt; 0.05).	Arginine	59-69	matrix metallopeptidase 9	Rattus norvegicus	134-139
16304337-11	2005	CONCLUSIONS: L-arginine attenuates APE-induced pulmonary hypertension through mechanisms involving increased NO synthesis and maybe attenuation of lung MMP-2 and MMP-9 activities.	Arginine	13-23	matrix metallopeptidase 9	Rattus norvegicus	162-167
16151465-1	2005	We have identified a gene polymorphism (K247R) within or close to the P-loop of BCR-ABL, which leads to the substitution of arginine for lysine.	Arginine	124-132	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-87
16210245-3	2005	Here, we show that endogenous, cytoplasmic splicing factor 2/alternative splicing factor (SF2/ASF) associated with the translation machinery is hypophosphorylated, suggesting that the phosphorylation state of the Arg-Ser-rich (RS) domain may influence the role of SF2/ASF in cytoplasmic RNA processing.	Arginine	213-216	serine and arginine rich splicing factor 1	Homo sapiens	90-93
16210245-3	2005	Here, we show that endogenous, cytoplasmic splicing factor 2/alternative splicing factor (SF2/ASF) associated with the translation machinery is hypophosphorylated, suggesting that the phosphorylation state of the Arg-Ser-rich (RS) domain may influence the role of SF2/ASF in cytoplasmic RNA processing.	Arginine	213-216	serine and arginine rich splicing factor 1	Homo sapiens	94-97
16210245-3	2005	Here, we show that endogenous, cytoplasmic splicing factor 2/alternative splicing factor (SF2/ASF) associated with the translation machinery is hypophosphorylated, suggesting that the phosphorylation state of the Arg-Ser-rich (RS) domain may influence the role of SF2/ASF in cytoplasmic RNA processing.	Arginine	213-216	serine and arginine rich splicing factor 1	Homo sapiens	264-267
16210245-3	2005	Here, we show that endogenous, cytoplasmic splicing factor 2/alternative splicing factor (SF2/ASF) associated with the translation machinery is hypophosphorylated, suggesting that the phosphorylation state of the Arg-Ser-rich (RS) domain may influence the role of SF2/ASF in cytoplasmic RNA processing.	Arginine	213-216	serine and arginine rich splicing factor 1	Homo sapiens	268-271
15960609-5	2005	Transmembrane prediction methods indicate that the slaty light mutation [G486R (Gly486--&gt;Arg)] may result in the sliding of the transmembrane domain towards the N-terminus, thus interfering with Dct function.	Arginine	92-95	dopachrome tautomerase	Mus musculus	198-201
16105738-1	2005	Extensive structure-activity relationship studies utilizing a beta-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His-D-Phe-Arg-Trp-Cys]-NH(2) (3), led to identification of a series of novel MC-4R selective disulfide-constrained hexapeptide analogs including Ac-[hCys-His-D-Phe-Arg-Trp-Cys]-NH(2) (12).	Arginine	106-109	melanocortin 4 receptor	Homo sapiens	196-201
16230382-5	2005	A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.	Arginine	19-27	Kruppel like factor 6	Homo sapiens	103-107
16135096-5	2005	Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3.	Arginine	91-94	dihydropyrimidinase like 3	Homo sapiens	16-22
16135096-5	2005	Analysis of the DPYSL3 protein sequence revealed a possible cleavage site for calpain (Val-Arg-Ser) on the C-terminus of DPYSL3.	Arginine	91-94	dihydropyrimidinase like 3	Homo sapiens	121-127
16030253-4	2005	Mutation of a single arginine residue within the importin-beta binding domain (IBB) disrupted the interaction with importin-beta, but preserved the ability of SPN to bind Xpo1 or TMG caps.	Arginine	21-29	snurportin 1	Homo sapiens	159-162
15935490-8	2005	In particular, [(pF)Phe(4), Aib(7), Aib(11), Arg(14), Lys(15)] N/OFQ-NH(2) was found to be a highly potent agonist with pK(i)=10.78 in binding studies and pEC(50)=9.37 in mouse vas deferens assay.	Arginine	45-48	prepronociceptin	Mus musculus	63-68
15935490-10	2005	[Nphe(1), (pF)Phe(4), Aib(7), Aib(11), Arg(14), Lys(15)] N/OFQ-NH(2) was the best antagonist with pA(2)=8.39 and showed high binding affinity with pK(i)=9.99.	Arginine	39-42	prepronociceptin	Mus musculus	57-62
15998636-0	2005	Arginine methylation of yeast mRNA-binding protein Npl3 directly affects its function, nuclear export, and intranuclear protein interactions.	Arginine	0-8	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	51-55
15998636-5	2005	Matrix-assisted laser desorption/ionization Fourier transform mass spectrometry was used to identify 17 methylated arginines in Npl3 purified from yeast: whereas 10 Arg-Gly-Gly (RGG) tripeptides were exclusively dimethylated, variable levels of methylation were found for 5 RGG and 2 RG motif arginines.	Arginine	115-124	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	128-132
15998636-6	2005	We constructed a set of Npl3 proteins in which subsets of the RGG arginines were mutated to lysine.	Arginine	66-75	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	24-28
15998636-9	2005	Npl3 with all 15 RGG arginines mutated to lysine exited the nucleus independent of Hmt1, indicating a direct effect of methylation on Npl3 transport.	Arginine	21-30	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	0-4
15998636-11	2005	These results support a model in which arginine methylation facilitates Npl3 export directly by weakening contacts with nuclear proteins.	Arginine	39-47	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	72-76
16141513-5	2005	This review introduces our novel "cell delivery system," which employs an Arg-Gly-Asp (RGD) fiber-mutant adenovirus vector encoding the chemokine or chemokine receptor gene in cancer immunotherapy.	Arginine	74-77	C-X-C motif chemokine receptor 4	Homo sapiens	149-167
15722127-1	2005	A non-peptide mimic of the Arg-Gly Asp (RGD) active sequence of adhesive proteins (such as vitronectin) has been equipped with two different spacer-arms for surface anchorage.	Arginine	27-30	vitronectin	Homo sapiens	91-102
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	108-111	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	108-111	insulin like growth factor 1 receptor	Homo sapiens	633-639
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	633-639
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	633-639
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	633-639
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	299-305
15928254-7	2005	RESULTS: We found the following results: 1) a heterozygous mutation (R709Q) changing the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Gln-Arg was identified in a 6-yr-old Japanese girl (case 1) and her mother who also had IUGR with short stature (case 2); 2) fibroblasts from case 2 contained more IGF-IR proreceptor protein (189 +/- 26% of normal) and less mature beta-subunit protein (63 +/- 12%); 3) [125I]IGF-I binding to fibroblasts from case 2 was reduced, compared with normal control (0.61 +/- 0.16 x 10(6) vs. 1.14 +/- 0.12 x 10(6) sites per cell; P &lt; 0.05); and 4) both IGF-I-stimulated [3H]thymidine incorporation and IGF-IR beta-subunit autophosphorylation were low in fibroblasts from case 2, compared with those of control (P &lt; 0.05).	Arginine	116-119	insulin like growth factor 1 receptor	Homo sapiens	633-639
16029433-5	2005	The analysis identified three novel exon 3 MASP2 variants introducing amino acid substitutions at positions 84 (Arg--&gt;Gln), 103 (Arg--&gt;Cys) and 111 (Pro--&gt;Leu) in the CUB1 domain.	Arginine	112-115	MBL associated serine protease 2	Homo sapiens	43-48
16029433-5	2005	The analysis identified three novel exon 3 MASP2 variants introducing amino acid substitutions at positions 84 (Arg--&gt;Gln), 103 (Arg--&gt;Cys) and 111 (Pro--&gt;Leu) in the CUB1 domain.	Arginine	132-135	MBL associated serine protease 2	Homo sapiens	43-48
15976236-2	2005	L-arginine transport mediated by cationic amino acid transporters (including CAT-1, CAT-2, CAT-2A, and CAT-2B) is crucial in regulating iNOS activity.	Arginine	0-10	dominant cataract 2	Mus musculus	84-89
16008515-4	2005	hRIP alpha is the longest isoform with 219 residues, containing a N-terminal arginine-rich basic region, followed by an acidic region and two C-terminal Zn finger-like structures.	Arginine	77-85	RPA interacting protein	Homo sapiens	0-4
16008515-8	2005	hRIP delta isoforms only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region.	Arginine	48-56	RPA interacting protein	Homo sapiens	0-4
15914278-3	2005	Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (&lt; or =60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR=1.46, 95% CI=1.06-2.99, P=0.02).	Arginine	181-184	X-ray repair cross complementing 1	Homo sapiens	172-177
15987940-5	2005	More severe dendrite loss is observed in abl-/-arg-/- neurons.	Arginine	47-50	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	41-44
15843372-7	2005	In vitronectin, GrB cleaves after an Arg-Lys-Asp (RGD) motif, which is part of the integrin-binding site found in matrix proteins.	Arginine	37-40	vitronectin	Homo sapiens	3-14
15845534-5	2005	Comparison of the actin-activated MgATPase activity and in vitro motility shows that mutation of residues Asn-97 and Arg-709 in HMM II-B and the homologous residue Arg-722 (Arg-730 in the alternatively spliced isoform) in HMM II-C decreases both parameters but affects in vitro motility more severely.	Arginine	117-120	myosin, heavy polypeptide 14	Mus musculus	226-230
15946904-3	2005	RESULTS: Three common polymorphisms were abundant in at least one allele in beta2AR resulting in a cysteine to arginine in the 5" promoter region (72% of patients), an arginine to glycine at amino acid-16 (Gly16; 86%), and a glutamine to glutamic acid at amino acid-27 (Glu27; 66%), a frequency that was no different to the normal Caucasian population.	Arginine	111-119	adrenoceptor beta 2	Homo sapiens	76-83
15946220-8	2005	Therefore, we constructed, expressed and characterized a TAFI mutant in which Ile182 and Ile183 were changed into the residues found in pancreas carboxypeptidase B at corresponding positions, Arg and Glu.	Arginine	192-195	carboxypeptidase B1	Homo sapiens	145-163
15688405-4	2005	Using both small interfering RNA- and plasmid based-RNA interference techniques, oncogenic NRAS was specifically suppressed in 2 human melanoma cell lines, 224 and BL, which harbor a codon 61 CAA (glutamine) to CGA (arginine) NRAS mutation.	Arginine	216-224	NRAS proto-oncogene, GTPase	Homo sapiens	91-95
15829507-3	2005	Unlike normal BLM, a double mutant BLM protein with lysine to arginine substitutions at residues 317 and 331 was not modified by SUMO, and it failed to localize efficiently to the PML nuclear bodies.	Arginine	62-70	BLM RecQ like helicase	Homo sapiens	35-38
15867160-4	2005	Screening of a large library of random mutants of the Escherichia coli endopeptidase OmpT led to the isolation of an enzyme variant, 1.3.19, that cleaved an Ala-Arg peptide bond instead of the Arg-Arg bond preferred by the WT enzyme.	Arginine	161-164	outer membrane protease	Escherichia coli	85-89
15867160-4	2005	Screening of a large library of random mutants of the Escherichia coli endopeptidase OmpT led to the isolation of an enzyme variant, 1.3.19, that cleaved an Ala-Arg peptide bond instead of the Arg-Arg bond preferred by the WT enzyme.	Arginine	193-196	outer membrane protease	Escherichia coli	85-89
15867160-4	2005	Screening of a large library of random mutants of the Escherichia coli endopeptidase OmpT led to the isolation of an enzyme variant, 1.3.19, that cleaved an Ala-Arg peptide bond instead of the Arg-Arg bond preferred by the WT enzyme.	Arginine	193-196	outer membrane protease	Escherichia coli	85-89
15867160-7	2005	These results can be explained by proposing that this mutation acts to "swap" the P(1) Arg side chain normally found in WT substrate peptides with the 223Arg side chain in the S(1) subsite of OmpT.	Arginine	87-90	outer membrane protease	Escherichia coli	192-196
15826653-5	2005	Here, we investigate the requirements for these two activities in L1 retrotransposition by examining the consequences of mutating two adjacent and highly conserved arginine residues in the ORF1p from mouse L1.	Arginine	164-172	L1 repeat, Tf subfamily, member 30	Mus musculus	189-194
15890005-7	2005	Similarily, GPx1 is activated by c-Abl- and Arg-mediated phosphorylation.	Arginine	44-47	glutathione peroxidase 1	Homo sapiens	12-16
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Arginine	215-218	coagulation factor X	Homo sapiens	33-36
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Arginine	215-218	coagulation factor X	Homo sapiens	33-36
15878741-8	2005	NAGS activity was detected in all three recombinant proteins but varied regarding activity levels and response to stimulation by l-arginine.	Arginine	129-139	N-acetylglutamate synthase	Homo sapiens	0-4
15644313-9	2005	Replacement of a single alanine residue in the pore of HCN1 (Ala-352) by an arginine residue present in HCN2 at equivalent position (Arg-405) induced HCN2-type chloride sensitivity in HCN1.	Arginine	133-136	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	55-59
15644313-9	2005	Replacement of a single alanine residue in the pore of HCN1 (Ala-352) by an arginine residue present in HCN2 at equivalent position (Arg-405) induced HCN2-type chloride sensitivity in HCN1.	Arginine	133-136	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	184-188
15695505-2	2005	Arginines B13 and B17 are each chelated by an aspartic acid/glutamic acid pair and by isoleucine B20, which, offset by a one-quarter helix turn from a straight line connecting the arginines, interacts with a cluster of hydrophobic amino acids.	Arginine	180-189	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	18-21
15777294-2	2005	Cellular uptake of L-arginine, modulated by the isozymes of type-2 cationic amino acid transporters (CAT), including CAT-2, CAT-2A and CAT-2B, has been reported to be a crucial factor in the regulation of iNOS activity.	Arginine	19-29	solute carrier family 7 member 2	Rattus norvegicus	117-122
15777294-2	2005	Cellular uptake of L-arginine, modulated by the isozymes of type-2 cationic amino acid transporters (CAT), including CAT-2, CAT-2A and CAT-2B, has been reported to be a crucial factor in the regulation of iNOS activity.	Arginine	19-29	solute carrier family 7 member 2	Rattus norvegicus	124-130
15777294-2	2005	Cellular uptake of L-arginine, modulated by the isozymes of type-2 cationic amino acid transporters (CAT), including CAT-2, CAT-2A and CAT-2B, has been reported to be a crucial factor in the regulation of iNOS activity.	Arginine	19-29	solute carrier family 7 member 2	Rattus norvegicus	135-141
18202875-9	2005	The second event was Leu--&gt;Arg change at position 43 in the GH receptor molecule that happened in the ancestor of Old world monkeys.	Arginine	30-33	growth hormone receptor	Homo sapiens	63-74
15751964-10	2005	Furthermore, point mutation of Arg(486) in the 3BP2-SH2 domain that couples ZAP-70 to LAT dramatically reduces NFAT activation.	Arginine	31-34	SH3-domain binding protein 2	Mus musculus	47-51
15751964-10	2005	Furthermore, point mutation of Arg(486) in the 3BP2-SH2 domain that couples ZAP-70 to LAT dramatically reduces NFAT activation.	Arginine	31-34	linker for activation of T cells	Mus musculus	86-89
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	agouti signaling protein	Homo sapiens	21-25
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	agouti related neuropeptide	Homo sapiens	203-207
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	melanocortin 4 receptor	Homo sapiens	208-213
15736952-6	2005	In the models of the ASIP fragment complexed with both receptors, the core ligand tripeptide, Arg-Phe-Phe, positioned between TMHs 3 and 6, is shifted toward TMHs 2 and 7 relative to its position in the AGRP-hMC4R model, while the N-terminal loop and two central disulfides of the antagonists interact with EL2 of the receptors.	Arginine	94-97	spectrin alpha, erythrocytic 1	Homo sapiens	307-310
15869001-2	2005	Trans-membrane L-arginine transportation mediated by type-2 cationic amino acid transporter (CAT-2) isozymes, including CAT-2, CAT-2A, and CAT-2B, is one of the crucial mechanisms that regulate NO biosynthesis by iNOS.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	93-98
15869001-2	2005	Trans-membrane L-arginine transportation mediated by type-2 cationic amino acid transporter (CAT-2) isozymes, including CAT-2, CAT-2A, and CAT-2B, is one of the crucial mechanisms that regulate NO biosynthesis by iNOS.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	120-125
15869001-2	2005	Trans-membrane L-arginine transportation mediated by type-2 cationic amino acid transporter (CAT-2) isozymes, including CAT-2, CAT-2A, and CAT-2B, is one of the crucial mechanisms that regulate NO biosynthesis by iNOS.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	127-133
15869001-2	2005	Trans-membrane L-arginine transportation mediated by type-2 cationic amino acid transporter (CAT-2) isozymes, including CAT-2, CAT-2A, and CAT-2B, is one of the crucial mechanisms that regulate NO biosynthesis by iNOS.	Arginine	15-25	solute carrier family 7 member 2	Rattus norvegicus	139-145
15767338-4	2005	Subjects with the XRCC1 Gln/Gln genotype were inversely associated with adenoma risk (odds ratio, 0.6; 95% confidence interval, 0.4-0.9; P = 0.01) when compared with subjects with Arg/Arg and Arg/Gln genotypes combined.	Arginine	184-187	X-ray repair cross complementing 1	Homo sapiens	18-23
15767338-4	2005	Subjects with the XRCC1 Gln/Gln genotype were inversely associated with adenoma risk (odds ratio, 0.6; 95% confidence interval, 0.4-0.9; P = 0.01) when compared with subjects with Arg/Arg and Arg/Gln genotypes combined.	Arginine	184-187	X-ray repair cross complementing 1	Homo sapiens	18-23
15767338-8	2005	High omega-6/omega-3 polyunsaturated fatty acid ratios were associated with adenoma risk among subjects with the XRCC1 codon 194 Arg/Arg and codon 399 Gln/Gln or the codon 194 Arg/Trp or Trp/Trp and codon 399 Arg/Arg or Arg/Gln combined genotypes (P for interaction = 0.026).	Arginine	129-132	X-ray repair cross complementing 1	Homo sapiens	113-118
15807279-9	2005	But in group LIR+L-Arg, the degree of pulmonary edema was alleviated, the MPO activity and MDA content were decreased, and the ratio of N/N increased; there was statistically significant difference between group LIR and group LIR+Arg in respect to the above indices (P&lt;0.01).	Arginine	17-22	myeloperoxidase	Oryctolagus cuniculus	74-77
15807279-9	2005	But in group LIR+L-Arg, the degree of pulmonary edema was alleviated, the MPO activity and MDA content were decreased, and the ratio of N/N increased; there was statistically significant difference between group LIR and group LIR+Arg in respect to the above indices (P&lt;0.01).	Arginine	19-22	myeloperoxidase	Oryctolagus cuniculus	74-77
15576449-3	2005	To investigate the molecular origin of the remaining slow component of charge immobilization we studied the human cardiac Na+ channel (hH1a) in which the outermost arginine in the S4-DIV, which contributes approximately 20% to total gating charge (Qmax), was mutated to a cysteine (R1C-DIV).	Arginine	164-172	H1.1 linker histone, cluster member	Homo sapiens	135-139
15841740-0	2005	Pulmonary vascular dilation induced by L-ARGININE: correlation with induction of endothelial nitric oxide synthase in a rabbit model.	Arginine	39-49	nitric oxide synthase, endothelial	Oryctolagus cuniculus	81-114
15841740-10	2005	Induction of eNOS was increased in the L-ARGININE-fed group.	Arginine	39-49	nitric oxide synthase, endothelial	Oryctolagus cuniculus	13-17
15841740-11	2005	CONCLUSION: The administration of L-ARGININE causes pulmonary vascular dilation, which is most likely mediated via nitric oxide through increased induction of eNOS in a rabbit model.	Arginine	34-44	nitric oxide synthase, endothelial	Oryctolagus cuniculus	159-163
15483229-9	2005	Furthermore, we provide evidence that extracellular L-arginine is a crucial requirement for normal PC Cl3 cell growth and that long-term L-arginine deprivation negatively influences CAT-2B expression, as it correlates to reduction of CAT-2B mRNA levels.	Arginine	137-147	solute carrier family 7 member 2	Rattus norvegicus	234-240
15750319-0	2005	Identification of an cysteine-to-arginine substitution caused by a single nucleotide polymorphism in the canine monoamine oxidase B gene.	Arginine	33-41	monoamine oxidase B	Canis lupus familiaris	112-131
15750319-2	2005	In this study, we first identified a single nucleotide polymorphism (T199C) located on the putative third exon of the canine monoamine oxidase B gene, which causes an amino acid substitution from cysteine to arginine.	Arginine	208-216	monoamine oxidase B	Canis lupus familiaris	125-144
15658852-2	2005	The utility of this methodology was demonstrated by the stereoselective synthesis of a set of diastereomeric EADIs of L-Arg-L/D-3-(2-naphthyl)alanine (Nal) that is contained in a small CXCR4 antagonist FC131 [cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)].	Arginine	118-123	C-X-C motif chemokine receptor 4	Homo sapiens	185-190
15615519-0	2004	Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist.	Arginine	74-77	agouti related neuropeptide	Homo sapiens	41-63
15615519-0	2004	Stereochemical studies of the monocyclic agouti-related protein (103-122) Arg-Phe-Phe residues: conversion of a melanocortin-4 receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist.	Arginine	74-77	melanocortin 4 receptor	Homo sapiens	112-135
18500948-3	2004	Athletes have taken arginine for three main reasons: 1) its role in the secretion of endogenous growth hormone; 2) its involvement in the synthesis of creatine; 3) its role in augmenting nitric oxide.	Arginine	20-28	growth hormone 2	Homo sapiens	96-113
15471871-0	2004	Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.	Arginine	64-72	coactivator associated arginine methyltransferase 1	Homo sapiens	102-107
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	coactivator associated arginine methyltransferase 1	Homo sapiens	46-51
15471871-8	2004	Therefore, histone methylation at Arg-17 by CARM1 is a downstream target of signaling through ligand-mediated activation of FXR.	Arginine	34-37	coactivator associated arginine methyltransferase 1	Homo sapiens	44-49
15491978-2	2004	The human cationic amino acid transporter hCAT-1 is almost ubiquitously expressed and probably the most important entity for supplying cells with extracellular arginine, lysine, and ornithine.	Arginine	160-168	solute carrier family 7 member 1	Homo sapiens	42-48
15491978-10	2004	Pretreatment with the PKC inhibitor bisindolylmaleimide I prevented the reduction by PMA of both hCAT-1.EGFP-induced arginine transport and the internalization of the transporter.	Arginine	117-125	solute carrier family 7 member 1	Homo sapiens	97-103
15494418-2	2004	Both bonds are accessible for cleavage, yet the sequential action of prothrombinase on Arg(320) followed by Arg(271) is implied by the intermediate observed during prothrombin activation.	Arginine	87-90	coagulation factor X	Homo sapiens	69-83
15494418-2	2004	Both bonds are accessible for cleavage, yet the sequential action of prothrombinase on Arg(320) followed by Arg(271) is implied by the intermediate observed during prothrombin activation.	Arginine	108-111	coagulation factor X	Homo sapiens	69-83
15494418-3	2004	We have studied the individual cleavage reactions catalyzed by prothrombinase by using a series of recombinant derivatives: wild type prothrombin (II(WT)) contained both cleavage sites; II(Q271) contained a single cleavable site at Arg(320); II(Q320) and II(A320) contained a single cleavable site at Arg(271); and II(QQ) was resistant to cleavage.	Arginine	232-235	coagulation factor X	Homo sapiens	63-77
15494418-3	2004	We have studied the individual cleavage reactions catalyzed by prothrombinase by using a series of recombinant derivatives: wild type prothrombin (II(WT)) contained both cleavage sites; II(Q271) contained a single cleavable site at Arg(320); II(Q320) and II(A320) contained a single cleavable site at Arg(271); and II(QQ) was resistant to cleavage.	Arginine	301-304	coagulation factor X	Homo sapiens	63-77
15585582-4	2004	One of these, KG-501 (2-naphthol-AS-E-phosphate), targeted a surface distal to the CREB binding groove that includes Arg-600, a residue that is required for the CREB:CBP interaction.	Arginine	117-120	cAMP responsive element binding protein 1	Homo sapiens	83-87
15585582-4	2004	One of these, KG-501 (2-naphthol-AS-E-phosphate), targeted a surface distal to the CREB binding groove that includes Arg-600, a residue that is required for the CREB:CBP interaction.	Arginine	117-120	cAMP responsive element binding protein 1	Homo sapiens	161-165
15548746-7	2004	p5cdh mutants were hypersensitive toward Pro and other molecules producing P5C, such as Arg and Orn.	Arginine	88-91	pyrroline-5-carboxylate reductase 1	Homo sapiens	75-78
15452864-6	2004	The NO donor, S-nitroso-N-acetylpenicillamine, decreased DAT activity and L-Arg protected the DAT from the effects of the sulfhydryl agent N-ethylmaleimide.	Arginine	74-79	solute carrier family 6 member 3	Homo sapiens	94-97
15541310-4	2004	Activation of CREB is also required for cAMP to upregulate Arg I, and the ability of constitutively active CREB to overcome inhibition is blocked by an inhibitor of polyamine synthesis.	Arginine	59-62	cAMP responsive element binding protein 1	Homo sapiens	14-18
15541310-4	2004	Activation of CREB is also required for cAMP to upregulate Arg I, and the ability of constitutively active CREB to overcome inhibition is blocked by an inhibitor of polyamine synthesis.	Arginine	59-62	cAMP responsive element binding protein 1	Homo sapiens	107-111
15531722-2	2004	In addition, the restriction of dietary arginine produced a marked decrease in body and renal weights as well as in the activity of renal ornithine decarboxylase, decreases that were gender dependent since they were observed exclusively in males.	Arginine	40-48	ornithine decarboxylase, structural 1	Mus musculus	138-161
15584934-6	2004	The effects of both NMDA and L-arginine were blocked by nitro-L-arginine methyl ester, suggesting that nNOS participates in responses to NMDA.	Arginine	29-39	nitric oxide synthase 1	Rattus norvegicus	103-107
15684686-5	2004	The current experiments analyze the interactions of isolated human neutrophils with PEG hydrogels modified with Arg-Gly-Asp-Ser (RGDS), a known ligand for some beta(1) and beta(3) integrins, and Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Thr-Ile-Gly-Gly (TMKIIPFNRLTIGG), a ligand for Mac-1, a beta(2) integrin.	Arginine	112-115	integrin subunit alpha M	Homo sapiens	282-287
15304513-5	2004	Immunodepletion studies indicated that the His to Arg point mutation solely rendered those GABAA receptors totally insensitive to diazepam binding that contain two mutated alpha subunits in the receptor complex, whereas receptors containing one mutated and one heterologous alpha subunit not carrying the mutation remained sensitive to diazepam binding.	Arginine	50-53	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	91-96
15452250-3	2004	The interacting region of HIV-2 Gag is located in the conserved matrix and capsid domains, while both the RS (arginine-serine-rich) domain and the KS (kinase) domain of PRP4 are able to bind to HIV-2 Gag.	Arginine	110-118	pre-mRNA processing factor 4B	Homo sapiens	169-173
15339660-5	2004	Deimination by PADI4 prevents arginine methylation by CARM1.	Arginine	30-38	coactivator associated arginine methyltransferase 1	Homo sapiens	54-59
15315617-3	2004	The isozymes of type-2 cationic amino acid transporters, including CAT-2, CAT-2A, and CAT-2B, constitute the most important pathways responsible for trans-membrane L-arginine transportation.	Arginine	164-174	solute carrier family 7 member 2	Rattus norvegicus	67-72
15315617-3	2004	The isozymes of type-2 cationic amino acid transporters, including CAT-2, CAT-2A, and CAT-2B, constitute the most important pathways responsible for trans-membrane L-arginine transportation.	Arginine	164-174	solute carrier family 7 member 2	Rattus norvegicus	74-80
15315617-3	2004	The isozymes of type-2 cationic amino acid transporters, including CAT-2, CAT-2A, and CAT-2B, constitute the most important pathways responsible for trans-membrane L-arginine transportation.	Arginine	164-174	solute carrier family 7 member 2	Rattus norvegicus	86-92
15327772-0	2004	Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes.	Arginine	0-8	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein	Mus musculus	24-29
15327772-5	2004	Arginine methylation of the amino terminus of NIP45 modulated its interaction with NFAT and resulted in augmented cytokine production, while T cells from mice lacking NIP45 had impaired expression of IFNgamma and IL-4.	Arginine	0-8	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein	Mus musculus	46-51
15327772-6	2004	Covalent modification of NIP45 by arginine methylation is an important mechanism of regulating the expression of NFAT-dependent cytokine genes.	Arginine	34-42	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein	Mus musculus	25-30
15289616-1	2004	Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for any amino acid.	Arginine	21-29	serum response factor	Homo sapiens	78-83
15289616-1	2004	Transcription of the arginine biosynthetic gene ARG1 is repressed by the ArgR/Mcm1p complex in arginine-replete cells and activated by Gcn4p, a transcription factor induced by starvation for any amino acid.	Arginine	95-103	serum response factor	Homo sapiens	78-83
14693504-8	2004	N(G)-nitro-l-arginine methyl ester enhanced and l-arginine inhibited basal and NT-induced TC uptake, consistent with the known inhibitory effect of nitric oxide (NO) on mast cell reactivity.	Arginine	11-21	neurotensin	Rattus norvegicus	79-81
15298559-7	2004	In asthmatic children, combinations of the IL-4 CT/TT genotype and the IL-4Ralpha Arg/Gln and Arg/Arg genotypes were associated with significantly increased risk for development of asthma (OR = 3.70, 95% CI = 1.07-12.78, P = 0.038).	Arginine	82-85	interleukin 4 receptor	Homo sapiens	71-81
15236321-5	2004	Both rat spetex-1 and the mouse homologue contained Ser-X (X = His, Arg, or Asn) repeats in the middle portion of the proteins.	Arginine	68-71	spermatogenesis associated 18	Rattus norvegicus	9-17
15068396-1	2004	The human splicing factor ASF/SF2 (alternative splicing factor/splicing factor 2) is modular in structure with two RNA-binding domains (RBD1 and RBD2) and a C-terminal domain rich in arginine-serine dipeptide repeats.	Arginine	183-191	serine and arginine rich splicing factor 1	Homo sapiens	26-33
15506055-9	2004	Conversely, in DS rats charged with 2% salt (in the food) during 7 weeks, L-arginine significantly inhibited NKCC2 in DS (35.6 +/- 6.8 vs 25.3 +/- 4.9 nmoles/mg protein/min; p&lt;0.05 non-paired Student"s t-test), but not in DR rats.	Arginine	74-84	solute carrier family 12 member 1	Rattus norvegicus	109-114
15064952-8	2004	Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression, via mechanisms involving membrane hyperpolarization, mitogen-activated protein kinases p42 and p44, phosphatidylinositol 3-kinase, NO and protein kinase C. We have characterized a cell signalling pathway by which hyperinsulinaemia could lead to vasodilatation in human subjects, and which could have implications in patients in whom plasma insulin levels are altered, such as in diabetes mellitus.	Arginine	36-46	solute carrier family 7 member 1	Homo sapiens	92-98
15066989-5	2004	In contrast, in the NO-bound ferric complexes, the addition of l-Arg alone does not affect the structural properties of the Fe-N-O moiety, but H4B binding forces it to adopt a bent structure, which is further enhanced by the subsequent addition of l-Arg.	Arginine	248-253	H4 clustered histone 4	Homo sapiens	143-146
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Rattus norvegicus	60-63
14992688-5	2004	Alanine substitutions at any one of these combined six arginine or glutamic acid residues inactivated Ftr1p in iron uptake, indicating that both motifs were essential to iron permeation.	Arginine	55-63	high-affinity iron permease FTR1	Saccharomyces cerevisiae S288C	102-107
15043949-9	2004	When the carboxy-terminal Arg was removed from all three C3a molecules, their ability to induce the respiratory burst was lost.	Arginine	26-29	complement C3	Homo sapiens	57-60
15354414-6	2004	Gene-gene interaction between the XRCC1 Arg/Arg and XRCC3 Met/Met homozygous variants slightly increased the risk (OR = 10.50; 95% CI 5.67-14.79).	Arginine	40-43	X-ray repair cross complementing 1	Homo sapiens	34-39
15354414-6	2004	Gene-gene interaction between the XRCC1 Arg/Arg and XRCC3 Met/Met homozygous variants slightly increased the risk (OR = 10.50; 95% CI 5.67-14.79).	Arginine	40-43	X-ray repair cross complementing 3	Homo sapiens	52-57
15354414-6	2004	Gene-gene interaction between the XRCC1 Arg/Arg and XRCC3 Met/Met homozygous variants slightly increased the risk (OR = 10.50; 95% CI 5.67-14.79).	Arginine	44-47	X-ray repair cross complementing 1	Homo sapiens	34-39
15354414-6	2004	Gene-gene interaction between the XRCC1 Arg/Arg and XRCC3 Met/Met homozygous variants slightly increased the risk (OR = 10.50; 95% CI 5.67-14.79).	Arginine	44-47	X-ray repair cross complementing 3	Homo sapiens	52-57
15134514-4	2004	The search for these compounds is based on the molecular design of structures mimicking some fragment of RGD (Arg-Gly-Asp) sequence, responsible for the binding of fibrinogen to GP IIb/IIIa.	Arginine	110-113	integrin subunit alpha 2b	Homo sapiens	178-184
15216398-10	2004	The frequency of arg/arg, arg/gln, and gln/gln in XRCC1 codon 399 in cases was 54% (54/100), 38% (38/100), and 8% (8/100) and in controls was 58% (114/196), 37% (73/196), and 5% (9/196), respectively, which was not significantly different.	Arginine	17-20	X-ray repair cross complementing 1	Homo sapiens	50-55
15216398-10	2004	The frequency of arg/arg, arg/gln, and gln/gln in XRCC1 codon 399 in cases was 54% (54/100), 38% (38/100), and 8% (8/100) and in controls was 58% (114/196), 37% (73/196), and 5% (9/196), respectively, which was not significantly different.	Arginine	21-24	X-ray repair cross complementing 1	Homo sapiens	50-55
15216398-10	2004	The frequency of arg/arg, arg/gln, and gln/gln in XRCC1 codon 399 in cases was 54% (54/100), 38% (38/100), and 8% (8/100) and in controls was 58% (114/196), 37% (73/196), and 5% (9/196), respectively, which was not significantly different.	Arginine	21-24	X-ray repair cross complementing 1	Homo sapiens	50-55
15039064-7	2004	The recombinant KE was refolded in arginine-containing dialysis solutions and the recovery of bioactive KE typically was approximately 70%.	Arginine	35-43	transforming growth factor beta induced	Homo sapiens	16-18
15096047-9	2004	Consistent with this notion, suv3 mutants containing alanine (A) or arginine (R) substitutions at the conserved lysine residue in the ATP binding site (K213) lost ATPase activity and also failed to unwind the substrates.	Arginine	68-76	Suv3 like RNA helicase	Homo sapiens	29-33
15066178-5	2004	Using heparin affinity chromatography, commonly employed in such studies, we define three clusters of arginines and lysines of CCP3, which are important for the interaction of PAPP-A with heparin.	Arginine	102-111	AGBL carboxypeptidase 3	Homo sapiens	127-131
14712329-1	2004	Important progress in arginine metabolism includes the discovery of widespread expression of two isoforms of arginase, arginase I and II, not only in hepatic cells but also in non-hepatic cells, and the formation of nitric oxide, a widely distributed signal-transducing molecule, from arginine by nitric oxide synthase.	Arginine	22-30	arginase 2	Rattus norvegicus	119-136
14712329-1	2004	Important progress in arginine metabolism includes the discovery of widespread expression of two isoforms of arginase, arginase I and II, not only in hepatic cells but also in non-hepatic cells, and the formation of nitric oxide, a widely distributed signal-transducing molecule, from arginine by nitric oxide synthase.	Arginine	285-293	arginase 2	Rattus norvegicus	119-136
14718525-3	2004	Here we show that S. pombe lacking tsc1+ or tsc2+ have similar phenotypes including decreased arginine uptake, decreased expression of three amino acid permeases, and low intracellular levels of four members of the arginine biosynthesis pathway.	Arginine	94-102	TSC complex subunit 2	Homo sapiens	44-48
14718525-3	2004	Here we show that S. pombe lacking tsc1+ or tsc2+ have similar phenotypes including decreased arginine uptake, decreased expression of three amino acid permeases, and low intracellular levels of four members of the arginine biosynthesis pathway.	Arginine	215-223	TSC complex subunit 2	Homo sapiens	44-48
14718525-5	2004	We show that the defect in arginine uptake in cells lacking tsc2+ is rescued by the expression of a dominant negative form of rhb1+, the Rheb homolog in S. pombe, but not by expressing wild-type rhb1+.	Arginine	27-35	TSC complex subunit 2	Homo sapiens	60-64
14718525-7	2004	Taken together, these findings support a model in which arginine uptake is regulated through tsc1+, tsc2+, and rhb1+ in S. pombe and also suggest a role for the Tsc1 and Tsc2 proteins in amino acid biosynthesis and sensing.	Arginine	56-64	TSC complex subunit 2	Homo sapiens	100-104
14718525-7	2004	Taken together, these findings support a model in which arginine uptake is regulated through tsc1+, tsc2+, and rhb1+ in S. pombe and also suggest a role for the Tsc1 and Tsc2 proteins in amino acid biosynthesis and sensing.	Arginine	56-64	TSC complex subunit 2	Homo sapiens	170-174
14764598-10	2004	In the MUC16 SEA domains, the conserved surface residues, Asn-10, Thr-12, Arg-63, Asp-75, Asp-112, Ser-115, and Phe-117, are clustered on the beta sheet surface, which may be functionally important.	Arginine	74-77	mucin 16	Mus musculus	7-12
15044002-9	2004	In human GDH isozymes, the 443 site is Arg in hGDH1 and Ser in hGDH2.	Arginine	39-42	glutamate dehydrogenase 2	Homo sapiens	63-68
15005625-3	2004	Previously, we identified Arg(150) on the autolysis loop of FXa as a candidate residue that may specifically interact with the heparin-activated AT.	Arginine	26-29	coagulation factor X	Homo sapiens	60-63
15016089-3	2004	The novel agonist [Arg(14),Lys(15)]N/OFQ also inhibited [(3)H]-5-HT overflow, but the concentration-response curve was biphasic and the efficacy higher ( approximately -45%).	Arginine	19-22	prepronociceptin	Mus musculus	35-40
15069780-1	2004	It has been suggested that the Arg 16/Gly 16 allele at codon 16 of beta 2-adrenoceptor polymorphism plays a role in down-regulating the stimulus of bronchodilatation caused by beta 2-agonists.	Arginine	31-34	adrenoceptor beta 2	Homo sapiens	67-86
14769921-0	2004	Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex.	Arginine	44-52	mRNA-binding protein	Saccharomyces cerevisiae S288C	86-90
14769921-2	2004	In this article, we show that the poly(A)(+) RNA-binding proteins Gbp2 and Hrb1, which resemble the serine-arginine-rich (SR) family of splicing factors found in higher eukaryotes, are specifically associated with the yeast TREX complex.	Arginine	107-115	mRNA-binding protein	Saccharomyces cerevisiae S288C	75-79
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Arginine	178-181	signal transducer and activator of transcription 1	Homo sapiens	125-130
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Arginine	178-181	signal transducer and activator of transcription 1	Homo sapiens	132-138
14623896-2	2004	To understand better the role of STAT1 in the interferon-gamma (IFN-gamma)-induced phenotype, we generated an active form of STAT1 (STAT1C) by substituting Cys residues for both Arg-656 and Asn-658 within the C-terminal loop of the STAT1 SH2 domain.	Arginine	178-181	signal transducer and activator of transcription 1	Homo sapiens	125-130
15125391-6	2004	MATERIALS AND METHODS: We compared the generation of C3a des Arg and C5b-9 and the changes in L and P counts in groups of patients on HD who used HP (3 patients), CD (3 patients) and AN69 membrane (3 patients).	Arginine	61-64	complement C3	Homo sapiens	53-56
15125391-10	2004	The mean plasma concentrations of C3a des Arg were 1246 +/- 832 ng/ml for HP, 1148 +/- 774 ng/ml for CD and 639 +/- 217 ng/ml for AN69 and significant difference was found comparing HP vs AN69, CD vs AN69 (p &lt; 0.05).	Arginine	42-45	complement C3	Homo sapiens	34-37
15125391-11	2004	The maximal values of C3a des Arg occurred at 15 min in HP and CD (p &lt; 0.005), whilst for AN69 the concentrations showed no statistically significant differences.	Arginine	30-33	complement C3	Homo sapiens	22-25
15225899-1	2004	To investigate the effect of X-ray repair cross complementing 1 (XRCC1) genetic polymorphisms on esophageal cancer risk, we determined XRCC1 polymorphisms at codon 194 (Arg --&gt; Trp) and codon 399 (Arg --&gt; Gln) in 135 patients with esophageal squamous cell carcinoma (ESCC) and 152 normal controls from hospitals.	Arginine	169-172	X-ray repair cross complementing 1	Homo sapiens	135-140
16201717-2	2004	Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ----&gt; [corrected] Gln, Arg 3500 ----&gt; [corrected] Trp and Arg 3531 ----&gt; [corrected] Cys).	Arginine	66-69	apolipoprotein B-100	Meleagris gallopavo	19-24
16201717-2	2004	Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ----&gt; [corrected] Gln, Arg 3500 ----&gt; [corrected] Trp and Arg 3531 ----&gt; [corrected] Cys).	Arginine	101-104	apolipoprotein B-100	Meleagris gallopavo	19-24
16201717-2	2004	Three mutations of Apo B-100 protein result in defective binding (Arg 3500 ----&gt; [corrected] Gln, Arg 3500 ----&gt; [corrected] Trp and Arg 3531 ----&gt; [corrected] Cys).	Arginine	101-104	apolipoprotein B-100	Meleagris gallopavo	19-24
16201717-3	2004	We estimated the frequency of Apo B point mutations (codon 3500) C9774T (Arg 3500 ----&gt; [corrected] Trp) and G9775A (Arg 3500 ----&gt; [corrected] Gln) in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey.	Arginine	73-76	apolipoprotein B-100	Meleagris gallopavo	30-35
15035777-1	2004	Constitutive and inducible isoforms of nitric oxide synthase (NOS) catalyze the synthesis of nitric oxide (NO) from L-arginine in various tissues and in different pathophysiologic states.	Arginine	116-126	nitric oxide synthase 3	Canis lupus familiaris	39-60
15165103-6	2004	ISH showed that the expression of HIF-1alpha mRNA in the intraacinar pulmonary arteriolae (IAPA) in normoxic control group (0.1076 +/- 0.0205) was markedly weaker than that in chronic hypoxic group (0.3317 +/- 0.0683, t=3.125, P&lt;0.05) and that in chronic hypoxic group was stronger than that in hypoxia plus L-arginine group (0.1928 +/- 0.0381, t=2.844, P&lt;0.05).	Arginine	311-321	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	34-44
15165103-7	2004	RT-PCR showed that the content of HIF-1alpha mRNA in chronic hypoxic group (2.5395 +/- 0.6449) was 2.16 times and 1.75 times higher than that in normoxic control group (1.1781 +/- 0.3628) and hypoxia plus L-arginine group (1.4511 +/- 0.3981), respectively.	Arginine	205-215	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	34-44
14583657-6	2004	The supplement of Arg significantly decreased the blood pressure in the low-sucrose LPD rats.	Arginine	18-21	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	84-87
14583657-7	2004	Urinary NOx, renal NO-generating capacity and the renal Arg content were significantly lower in the low-sucrose LPD rats than in the NPD rats.	Arginine	56-59	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	112-115
14583657-8	2004	Arg supplementation to the LPD rats returned these values to the level of the NPD rats.	Arginine	0-3	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	27-30
14583657-9	2004	CONCLUSION: The increase in blood pressure by LPD was associated with the higher amount of sucrose contained in LPD and the decrease in NO generation caused by the Arg depletion in rats with post-CsA nephropathy.	Arginine	164-167	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	46-49
14674748-11	2003	It is suggested that Ser phosphorylation allows protein-protein association by electrostatic stabilization: an obvious negative binding region of Vpu was recognizable by positive residues (Arg and Lys) of the WD domain of beta-TrCP.	Arginine	189-192	Vpu	Human immunodeficiency virus 1	146-149
14637132-4	2003	Rat MGST3 fails to convert leukotriene A(4) into leukotriene C(4), which in turn challenges the proposed catalytic role of a conserved Arg and Tyr residue for the leukotriene C(4) synthase reaction.	Arginine	135-138	microsomal glutathione S-transferase 3	Rattus norvegicus	4-9
14674686-8	2003	Full protection of ETF from arginine modification by 2,3-butanedione was achieved using substrate-protected DMGDH, MCAD and SDH respectively.	Arginine	28-36	dimethylglycine dehydrogenase	Homo sapiens	108-113
14674686-8	2003	Full protection of ETF from arginine modification by 2,3-butanedione was achieved using substrate-protected DMGDH, MCAD and SDH respectively.	Arginine	28-36	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	124-127
14674686-10	2003	These results lead us to conclude that this single arginine residue is essential in the binding of the ETF to MCAD, but only contributes partially to the binding of ETF to SDH and DMGDH and thus, the determinants of the dehydrogenase binding sites overlap but are not identical.	Arginine	51-59	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	172-175
14674686-10	2003	These results lead us to conclude that this single arginine residue is essential in the binding of the ETF to MCAD, but only contributes partially to the binding of ETF to SDH and DMGDH and thus, the determinants of the dehydrogenase binding sites overlap but are not identical.	Arginine	51-59	dimethylglycine dehydrogenase	Homo sapiens	180-185
14627736-7	2003	Sequence alignment and structural comparison suggest that these Arg-Asp interactions are highly conserved in SF2 DEx(D/H) proteins.	Arginine	64-67	serine and arginine rich splicing factor 1	Homo sapiens	109-112
14615587-5	2003	Our results show that eliminating an intra-subunit interaction between Asp-155 and Arg-395 results in conversion of the allosteric switch of GroEL from concerted to sequential, thus demonstrating that its allosteric behavior arises from coupled tertiary conformational changes.	Arginine	83-86	heat shock protein family D (Hsp60) member 1	Homo sapiens	141-146
14652281-4	2003	Carriers of at least one variant allele of XRCC1 Arg194Trp [Arg/Trp and Trp/Trp versus Arg/Arg, odds ratio (OR) = 1.60, 95% confidence interval (CI) = 0.89-2.87] or two variant alleles of XRCC3 241Met/Metmay have an increased risk of breast cancer (Met/Met versus Thr/Thr and Thr/Met, OR = 1.54, 95% CI = 0.94-2.52).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	43-48
14652281-4	2003	Carriers of at least one variant allele of XRCC1 Arg194Trp [Arg/Trp and Trp/Trp versus Arg/Arg, odds ratio (OR) = 1.60, 95% confidence interval (CI) = 0.89-2.87] or two variant alleles of XRCC3 241Met/Metmay have an increased risk of breast cancer (Met/Met versus Thr/Thr and Thr/Met, OR = 1.54, 95% CI = 0.94-2.52).	Arginine	49-52	X-ray repair cross complementing 3	Homo sapiens	188-193
14652281-4	2003	Carriers of at least one variant allele of XRCC1 Arg194Trp [Arg/Trp and Trp/Trp versus Arg/Arg, odds ratio (OR) = 1.60, 95% confidence interval (CI) = 0.89-2.87] or two variant alleles of XRCC3 241Met/Metmay have an increased risk of breast cancer (Met/Met versus Thr/Thr and Thr/Met, OR = 1.54, 95% CI = 0.94-2.52).	Arginine	60-63	X-ray repair cross complementing 1	Homo sapiens	43-48
14652281-4	2003	Carriers of at least one variant allele of XRCC1 Arg194Trp [Arg/Trp and Trp/Trp versus Arg/Arg, odds ratio (OR) = 1.60, 95% confidence interval (CI) = 0.89-2.87] or two variant alleles of XRCC3 241Met/Metmay have an increased risk of breast cancer (Met/Met versus Thr/Thr and Thr/Met, OR = 1.54, 95% CI = 0.94-2.52).	Arginine	60-63	X-ray repair cross complementing 1	Homo sapiens	43-48
14504257-0	2003	L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats.	Arginine	0-10	cytochrome b-245 beta chain	Rattus norvegicus	32-40
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Arginine	189-197	ciliary neurotrophic factor	Homo sapiens	18-45
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Arginine	189-197	ciliary neurotrophic factor	Homo sapiens	47-51
14631757-3	2003	Here we show that ciliary neurotrophic factor (CNTF) readily aggregates upon exposure to mechanical stress such as agitation and elevated temperature at 37 degrees C. Sucrose and lysine or arginine protect CNTF from heat stress, while detergents such as Tween20 and organic solvents such as propylene glycol (PG) are effective against agitation.	Arginine	189-197	ciliary neurotrophic factor	Homo sapiens	206-210
14567685-0	2003	Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase.	Arginine	28-36	sulfite oxidase	Homo sapiens	86-101
14567685-1	2003	Arginine 160 in human sulfite oxidase (SO) is conserved in all SO species sequenced to date.	Arginine	0-8	sulfite oxidase	Homo sapiens	22-37
14567685-1	2003	Arginine 160 in human sulfite oxidase (SO) is conserved in all SO species sequenced to date.	Arginine	0-8	sulfite oxidase	Homo sapiens	39-41
14567685-1	2003	Arginine 160 in human sulfite oxidase (SO) is conserved in all SO species sequenced to date.	Arginine	0-8	sulfite oxidase	Homo sapiens	63-65
14576432-4	2003	These findings provide a molecular basis for BRCT domain function in the DNA damage response and may help to explain why the BRCA1 BRCT domain mutation Met1775 --&gt; Arg, which fails to bind phosphopeptides, predisposes women to breast and ovarian cancer.	Arginine	167-170	BRCA1 DNA repair associated	Homo sapiens	125-130
12890667-4	2003	The gene products differ in three amino acid residues: Ile67 (Val), Ala92 (Thr), and Lys251 (Arg) in Etr2p (Etr1p).	Arginine	93-96	enoyl-[acyl-carrier-protein] reductase	Saccharomyces cerevisiae S288C	108-113
12944416-5	2003	Here we show that L-ORD is genetically heterogeneous and that a proposed founder mutation in the CTRP5 (C1QTNF5) gene, which encodes a novel short-chain collagen, changes a highly conserved serine to arginine (Ser163Arg) in 7/14 L-ORD families and 0/1000 control individuals.	Arginine	200-208	C1q and TNF related 5	Homo sapiens	97-102
12944416-5	2003	Here we show that L-ORD is genetically heterogeneous and that a proposed founder mutation in the CTRP5 (C1QTNF5) gene, which encodes a novel short-chain collagen, changes a highly conserved serine to arginine (Ser163Arg) in 7/14 L-ORD families and 0/1000 control individuals.	Arginine	200-208	C1q and TNF related 5	Homo sapiens	104-111
14526079-4	2003	Purified AtNOS1 protein used the substrates arginine and nicotinamide adenine dinucleotide phosphate and was activated by Ca2+ and calmodulin-like mammalian endothelial nitric oxide synthase and neuronal nitric oxide synthase, yet it is a distinct enzyme with no sequence similarities to any mammalian isoform.	Arginine	44-52	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	9-15
12816759-11	2003	Our results indicate that OXA inhibition of the MMC involves the OX1R and that activation of a L-arginine/NO pathway possibly originating from OX1R/nNOS-containing neurons in the myenteric plexus may mediate this effect.	Arginine	95-105	nitric oxide synthase 1	Rattus norvegicus	148-152
14578150-7	2003	For XRCC1 codon 280 genotypes of Arg/His and His/His compared with the Arg/Arg genotype, the OR was 0.64 (95% CI, 0.43-0.96).	Arginine	33-36	X-ray repair cross complementing 1	Homo sapiens	4-9
14557466-2	2003	The goal of the present study was to assess the association between the Gly(16)--&gt;Arg(16) and Gln(27)--&gt;Glu(27) polymorphisms of the beta(2)-adrenergic receptor and metabolic syndrome.	Arginine	85-88	adrenoceptor beta 2	Homo sapiens	139-166
12857728-0	2003	A region of the Epstein-Barr virus (EBV) mRNA export factor EB2 containing an arginine-rich motif mediates direct binding to RNA.	Arginine	78-86	microtubule associated protein RP/EB family member 2	Homo sapiens	60-63
12777400-8	2003	In addition, c-abl-/- arg-/- cells exhibited a marked increase in H2O2-induced apoptosis compared with that found in the absence of either kinase.	Arginine	22-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	13-18
12747801-4	2003	Modification of these sites to arginine dramatically reduces ubiquitination of XIAP, but has no measurable effect on the ability of ectopically expressed IAP to rescue cells from two independent apoptotic inducers.	Arginine	31-39	X-linked inhibitor of apoptosis	Homo sapiens	79-83
12689334-6	2003	Furthermore, SDS/PAGE and Western-blot experiments showed that the specific appearance of the 44 kDa A2 domain on cleavage of the FVIII Arg(372)-Ser(373) peptide bond was delayed significantly in the presence of either GpIbalpha 1-282 or GpIb 268-282 peptide.	Arginine	136-139	glycoprotein Ib platelet subunit alpha	Homo sapiens	219-228
12689334-9	2003	Taken together, these experiments suggest that the sulphated 268-282 region of GpIbalpha binds to thrombin HBS, and is responsible for the inhibition of the Arg(372)-Ser(373) bond cleavage and activation of FVIII.	Arginine	157-160	glycoprotein Ib platelet subunit alpha	Homo sapiens	79-88
12832612-3	2003	We began with a modified eglin c, Arg-42-Arg-45-eglin, in which the reactive site loop had been optimized for subtilisin-related processing proteases of the Kex2/furin family.	Arginine	34-37	kexin KEX2	Saccharomyces cerevisiae S288C	157-161
12662153-10	2003	Our data revealed further the critical role of the last two basic amino acid residues (e.g. Lys(82)-Arg(83) for the mouse PC1/3 sequence) of the prodomain in imparting a strong anti-convertase activity.	Arginine	100-103	proprotein convertase subtilisin/kexin type 1	Mus musculus	122-127
12820891-9	2003	The coplanar system between the electronegative tip and guanidine-amidine moiety extends the conjugation and facilitates negative charge (delta(-)) flow toward the tip, thereby enhancing interaction with the proposed cationic subsite such as lysine or arginine in the Drosophila nAChR.	Arginine	252-260	nicotinic Acetylcholine Receptor beta1	Drosophila melanogaster	279-284
12823310-4	2003	A heterozygous nucleotide G--&gt;A transition at position 6208 in exon 74 of COL7A1 was detected, which resulted in a glycine to arginine substitution (G2070R) in the triple-helical domain of type VII collagen.	Arginine	129-137	collagen type VII alpha 1 chain	Homo sapiens	77-83
12831960-7	2003	H(4)B in turn enhances NO generation and augments arginine transport into the cells.	Arginine	50-58	H4 clustered histone 4	Homo sapiens	0-5
12795599-5	2003	Arg 600 is a site for regulatory methylation by CARM1/PRMT4, which negates the CREB-binding function of the KIX domain.	Arginine	0-3	coactivator associated arginine methyltransferase 1	Homo sapiens	48-53
12795599-5	2003	Arg 600 is a site for regulatory methylation by CARM1/PRMT4, which negates the CREB-binding function of the KIX domain.	Arginine	0-3	coactivator associated arginine methyltransferase 1	Homo sapiens	54-59
12795599-5	2003	Arg 600 is a site for regulatory methylation by CARM1/PRMT4, which negates the CREB-binding function of the KIX domain.	Arginine	0-3	cAMP responsive element binding protein 1	Homo sapiens	79-83
12763038-4	2003	In the oocytes injected with rBAT cRNA alone, the activities of cystine and arginine transport were induced, indicating that the system b(0,+)-like transporter was expressed by associating the exogenous rBAT with an endogenous b(0,+)AT-like factor as reported previously.	Arginine	76-84	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	29-33
12763038-4	2003	In the oocytes injected with rBAT cRNA alone, the activities of cystine and arginine transport were induced, indicating that the system b(0,+)-like transporter was expressed by associating the exogenous rBAT with an endogenous b(0,+)AT-like factor as reported previously.	Arginine	76-84	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	203-207
12560211-1	2003	Nitric oxide (NO) is synthesized from l-arginine by the Ca(2+)/calmodulin-sensitive endothelial NO synthase (NOS) isoform (eNOS).	Arginine	38-48	nitric oxide synthase 3	Rattus norvegicus	123-127
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Arginine	125-135	solute carrier family 7 member 1	Homo sapiens	110-115
12562561-2	2003	An activator of classical and novel isoforms of PKC, phorbol 12-myristate-13-acetate (PMA; 100 nM), inhibited CAT-1-mediated l-arginine transport in PAEC after a 1-h treatment and activated l-arginine uptake after an 18-h treatment of cells.	Arginine	190-200	solute carrier family 7 member 1	Homo sapiens	110-115
12729605-2	2003	The enzyme substrate (biotin-RYRGLMVGGVVR-OH) is cleaved by CPB at the C terminus, causing release of the C-terminal Arg residue.	Arginine	117-120	carboxypeptidase B1	Homo sapiens	60-63
12787142-3	2003	We have found that the Glu-Leu-Arg-negative CXC chemokines interferon gamma inducible protein 10, monokine induced by interferon gamma, and platelet factor 4, limit fibroblast responsiveness to growth factors, but the functioning of these factors in wound healing remains uncertain.	Arginine	31-34	C-X-C motif chemokine ligand 10	Homo sapiens	59-96
12733060-4	2003	In this work, we demonstrated that the NFO3 gene is identical to OLE1 and that the nfo3-1 mutation (renamed ole1-101) alters arginine-346, in the vicinity of the conserved histidine-rich motif essential for the catalytic function of the Ole1 protein, to lysine.	Arginine	125-133	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	108-112
12733060-4	2003	In this work, we demonstrated that the NFO3 gene is identical to OLE1 and that the nfo3-1 mutation (renamed ole1-101) alters arginine-346, in the vicinity of the conserved histidine-rich motif essential for the catalytic function of the Ole1 protein, to lysine.	Arginine	125-133	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	237-241
12747782-6	2003	Their replacement, in the Pro3 analogue, with additional Arg residues led to analogues with improved kappa affinity (e.g., [Pro3,Arg8]Dyn A(1-11)-NH2 20: K(i)(kappa) = 0.44 nM).	Arginine	57-60	pyrroline-5-carboxylate reductase 1	Homo sapiens	26-30
12747782-6	2003	Their replacement, in the Pro3 analogue, with additional Arg residues led to analogues with improved kappa affinity (e.g., [Pro3,Arg8]Dyn A(1-11)-NH2 20: K(i)(kappa) = 0.44 nM).	Arginine	57-60	pyrroline-5-carboxylate reductase 1	Homo sapiens	124-128
12606556-2	2003	Factor Xa attacks two sites in A1, Arg(336), which precedes the highly acidic C-terminal region, and a recently identified site at Lys(36).	Arginine	35-38	coagulation factor X	Homo sapiens	0-9
12718547-0	2003	Identification of lysine 122 and arginine 196 as important functional residues of rat CTP:phosphocholine cytidylyltransferase alpha.	Arginine	33-41	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	86-131
12718547-2	2003	We have investigated the catalytic role of lysine 122 and arginine 196 of rat CCTalpha using site-directed mutagenesis and a baculovirus expression system.	Arginine	58-66	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	78-86
12718547-8	2003	These data suggest lysine 122 and arginine 196 of rat CTP:phosphocholine cytidylyltransferase are functionally important amino acids, perhaps at or near the active site involved in forming contacts with the substrates phosphocholine and CTP, respectively.	Arginine	34-42	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	54-93
12711671-5	2003	The recombinant ELAC2 was able to cleave human pre-tRNA(Arg) efficiently.	Arginine	56-59	elaC ribonuclease Z 2	Homo sapiens	16-21
12895647-7	2003	In addition, substitution of lysine for arginine residues in the CKS-17 sequence completely abrogates the ability of CKS-17 to phosphorylate PKD/PKCmu.	Arginine	40-48	protein kinase D1	Homo sapiens	141-144
12895647-7	2003	In addition, substitution of lysine for arginine residues in the CKS-17 sequence completely abrogates the ability of CKS-17 to phosphorylate PKD/PKCmu.	Arginine	40-48	protein kinase D1	Homo sapiens	145-150
12704081-3	2003	Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter.	Arginine	130-133	protein arginine methyltransferase 1	Homo sapiens	165-170
12692111-6	2003	Overall, the adjusted odds ratio (OR) of XRCC1 Arg399Gln polymorphism (Gln/Gln versus Arg/Arg) was 1.3 [95% confidence interval (CI), 1.0-1.8].	Arginine	47-50	X-ray repair cross complementing 1	Homo sapiens	41-46
12692111-6	2003	Overall, the adjusted odds ratio (OR) of XRCC1 Arg399Gln polymorphism (Gln/Gln versus Arg/Arg) was 1.3 [95% confidence interval (CI), 1.0-1.8].	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	41-46
12614872-1	2003	Four optically pure conformationally restricted L-arginine analogues syn- 1 and anti- 2 trans-3,4-cyclopropyl L-arginine, and syn- 3 and anti-trans-3,4-cyclopropyl N-(1-iminoethyl) L-ornithine 4 were synthesized.	Arginine	48-58	synapsin I	Homo sapiens	69-75
12562917-8	2003	The actions of vitronectin were sensitive to RGD (Arg-Gly-Asp)-sequence-containing peptide, indicating the involvement of integrins as vitronectin receptors.	Arginine	50-53	vitronectin	Mus musculus	15-26
12562917-8	2003	The actions of vitronectin were sensitive to RGD (Arg-Gly-Asp)-sequence-containing peptide, indicating the involvement of integrins as vitronectin receptors.	Arginine	50-53	vitronectin	Mus musculus	135-146
12581808-7	2003	Together with the novel mutation, R79L, four different nucleotide changes altering the R79 residue have been reported, implying that any alternation of this arginine residue can give the GFAP protein a dominant negative effect, leading to accumulation of GFAP as Rosenthal fibers.	Arginine	157-165	glial fibrillary acidic protein	Homo sapiens	187-191
12581808-7	2003	Together with the novel mutation, R79L, four different nucleotide changes altering the R79 residue have been reported, implying that any alternation of this arginine residue can give the GFAP protein a dominant negative effect, leading to accumulation of GFAP as Rosenthal fibers.	Arginine	157-165	glial fibrillary acidic protein	Homo sapiens	255-259
12562911-6	2003	Mutating the pore variant C-terminal to the GYG motif in HCN1, A352, to the analogous conserved Asp in K+ channels or Arg in HCN2 produced a significant hyperpolarizing activation shift (by 5-15 mV), slowed gating kinetics (up to 6-fold), and abolished or attenuated gating responses to external K+.	Arginine	118-121	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	57-61
12631327-4	2003	The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity).	Arginine	173-181	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	37-44
12631327-7	2003	AtmBAC1 appeared to be more stereospecific than the yeast and mammalian ornithine carriers, exhibiting greater preference for the l-forms of arginine, lysine and ornithine.	Arginine	141-149	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	0-7
12631327-9	2003	Expression of AtmBAC1 in seedlings is consistent with its involvement in Arg breakdown in early seedling development, i.e. delivery of Arg to mitochondrial arginase.	Arginine	73-76	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	14-21
12631327-9	2003	Expression of AtmBAC1 in seedlings is consistent with its involvement in Arg breakdown in early seedling development, i.e. delivery of Arg to mitochondrial arginase.	Arginine	135-138	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	14-21
12631327-10	2003	The Km (0.19 mm) for Arg uptake by AtmBAC1 was close to the value we previously determined for the saturable component of Arg uptake into intact mitochondria from soybean seedling cotyledons.	Arginine	21-24	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	35-42
12631327-10	2003	The Km (0.19 mm) for Arg uptake by AtmBAC1 was close to the value we previously determined for the saturable component of Arg uptake into intact mitochondria from soybean seedling cotyledons.	Arginine	122-125	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	35-42
12496269-1	2003	Prothrombinase cleaves prothrombin at Arg(271) and Arg(320) to produce thrombin.	Arginine	38-41	coagulation factor X	Homo sapiens	0-14
12496269-1	2003	Prothrombinase cleaves prothrombin at Arg(271) and Arg(320) to produce thrombin.	Arginine	51-54	coagulation factor X	Homo sapiens	0-14
12590608-4	2003	Using synthetic peptide substrates modeled on synapsin I, a substrate recognition motif for DCK1 of Hyd-Arg-Arg-X-X-Ser/Thr-Hyd was derived.	Arginine	104-107	synapsin I	Homo sapiens	46-56
12590608-4	2003	Using synthetic peptide substrates modeled on synapsin I, a substrate recognition motif for DCK1 of Hyd-Arg-Arg-X-X-Ser/Thr-Hyd was derived.	Arginine	108-111	synapsin I	Homo sapiens	46-56
12639550-1	2003	A series of pentapeptides, based on hMC4R pentapeptide agonist (Bu-His(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2)), was prepared in which either DPhe(7) or Trp(9) residue was systematically substituted.	Arginine	81-85	melanocortin 4 receptor	Homo sapiens	36-41
12561067-6	2003	39.5% (15/38) of point mutations were CGT (Arg) to CAT (His) mutation at codon-273 of exon-8.	Arginine	43-46	UDP glycosyltransferase 8	Homo sapiens	38-41
14631847-9	2003	As for CARM1, acetylation of multiple lysines within histone H3 facilitates arginine methylation of by CARM1.	Arginine	76-84	coactivator associated arginine methyltransferase 1	Homo sapiens	7-12
14631847-9	2003	As for CARM1, acetylation of multiple lysines within histone H3 facilitates arginine methylation of by CARM1.	Arginine	76-84	coactivator associated arginine methyltransferase 1	Homo sapiens	103-108
12559843-4	2003	Finally, AL is required for the endogenous production of arginine.	Arginine	57-65	argininosuccinate lyase	Mus musculus	9-11
12509629-5	2003	The arginine-glycine-rich domain in hnRNP A2 was found to be the reaction site, and the methylation of hnRNP A2 by PRMT1 (protein arginine methyltransferase 1) was increased by anti-DNA.	Arginine	4-12	protein arginine methyltransferase 1	Homo sapiens	115-120
12509629-5	2003	The arginine-glycine-rich domain in hnRNP A2 was found to be the reaction site, and the methylation of hnRNP A2 by PRMT1 (protein arginine methyltransferase 1) was increased by anti-DNA.	Arginine	4-12	protein arginine methyltransferase 1	Homo sapiens	122-158
12498683-3	2002	The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, but the existence of a crosstalk between lysine acetylation and arginine methylation on chromatin has not yet been established in vivo.	Arginine	188-196	coactivator associated arginine methyltransferase 1	Homo sapiens	31-36
12498683-8	2002	A mechanism for the observed cooperation between acetylation and arginine methylation comes from the finding that acetylation at K18 and K23, but not K14, tethers recombinant CARM1 to the H3 tail and allows it to act as a more efficient arginine methyltransferase.	Arginine	65-73	keratin 23	Homo sapiens	137-140
12498683-8	2002	A mechanism for the observed cooperation between acetylation and arginine methylation comes from the finding that acetylation at K18 and K23, but not K14, tethers recombinant CARM1 to the H3 tail and allows it to act as a more efficient arginine methyltransferase.	Arginine	65-73	coactivator associated arginine methyltransferase 1	Homo sapiens	175-180
12470634-7	2002	These results suggest that Arg plays a role in homologous recombinational (HR) DNA repair by phosphorylating Rad51.	Arginine	27-30	RAD51 recombinase	Homo sapiens	109-114
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Arginine	103-106	carboxypeptidase E	Mus musculus	12-15
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Arginine	103-106	carboxypeptidase D	Mus musculus	19-37
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Arginine	103-106	thyrotropin releasing hormone	Mus musculus	84-87
12270926-11	2002	Recombinant CPE or carboxypeptidase D can convert synthetic TRH-[Gly(4)-Lys(5)] and TRH-[Gly(4)-Lys(5)-Arg(6)] to TRH-[Gly(4)].	Arginine	103-106	thyrotropin releasing hormone	Mus musculus	84-87
12459178-6	2002	A cDNA sequence containing the "conserved domain" complements an NAGS-deficient Escherichia coli strain and the recombinant protein has arginine-responsive NAGS catalytic activity.	Arginine	136-144	N-acetylglutamate synthase	Homo sapiens	65-69
12402313-4	2002	Wild-type ST1A3*1 ((213)Arg) alleles were slightly overrepresented in nonsmoking urothelial cancer patients (82.6% vs. 69.7%) and in smoking cancer patients (76.7% and 74.3%) compared to a variant ST1A3*2 ((213)His) allele.	Arginine	24-27	sulfotransferase family 1A member 3	Homo sapiens	10-15
12402313-4	2002	Wild-type ST1A3*1 ((213)Arg) alleles were slightly overrepresented in nonsmoking urothelial cancer patients (82.6% vs. 69.7%) and in smoking cancer patients (76.7% and 74.3%) compared to a variant ST1A3*2 ((213)His) allele.	Arginine	24-27	sulfotransferase family 1A member 3	Homo sapiens	197-202
12464940-5	2002	Individuals homozygous for arginine at locus 16 of the beta(2)-adrenergic receptor gene have a decline in pulmonary function during beta(2)-agonist use, and they are at greater risk of asthma exacerbations during beta(2)-agonist therapy than patients with other genotypes.	Arginine	27-35	adrenoceptor beta 2	Homo sapiens	55-82
12466543-0	2002	Methylation of Xenopus CIRP2 regulates its arginine- and glycine-rich region-mediated nucleocytoplasmic distribution.	Arginine	43-51	cold inducible RNA binding protein S homeolog	Xenopus laevis	23-28
12466543-4	2002	We found that an arginine- and glycine-rich region of xCIRP2, termed the RG4 domain, was a target of xPRMT1 for methylation in vitro.	Arginine	17-25	cold inducible RNA binding protein S homeolog	Xenopus laevis	54-60
12466543-4	2002	We found that an arginine- and glycine-rich region of xCIRP2, termed the RG4 domain, was a target of xPRMT1 for methylation in vitro.	Arginine	17-25	protein arginine methyltransferase 1 S homeolog	Xenopus laevis	101-107
12427028-0	2002	A highly conserved arginine is critical for the functional folding of inhibitor of apoptosis (IAP) BIR domains.	Arginine	19-27	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	94-97
12427028-4	2002	The functional and structural role of the Arg was investigated in isolated BIR domains from the baculovirus Orgyia pseudotsugata Op-IAP and the Drosophila DIAP1 proteins.	Arginine	42-45	Death-associated inhibitor of apoptosis 1	Drosophila melanogaster	132-135
12427028-5	2002	Mutation of the Arg to either Ala or Lys abolished Hid and Smac binding to BIRs, despite the Hid/Smac binding site being located on the opposite side of the BIR domain from the Arg.	Arginine	16-19	diablo	Drosophila melanogaster	59-63
12429500-0	2002	Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.	Arginine	27-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	103-108
12429500-5	2002	To qualitatively assess the role arginine 80 plays in both selecting and stabilizing NADPH binding, it was replaced with each amino acid and the mutant enzymes subjected to enzymatic analysis.	Arginine	33-41	2,4-dienoyl-CoA reductase 1	Homo sapiens	85-90
12403624-4	2002	Reverting the Arg(19) substitution of [M]PTH(1-20) to the native Glu reduced cAMP signaling potency on P1R-delNt by 12-fold (EC(50) of [M]PTH(1-20)-Glu(19) = 27 +/- 4 nM), and it decreased the analog"s capacity to inhibit the binding of the J domain-selective radioligand, (125)I-[Aib(1,3),Nle(8),M,Tyr(21)]ratPTH(1-21), to the full-length P1R stably expressed in LLC-PK1 cells by 40-fold.	Arginine	14-17	parathyroid hormone	Sus scrofa	41-44
12196513-7	2002	Transfection of Rap1b mutants S17N (Ser --&gt; Asn) or T61R (Thr --&gt; Arg) in MCs inhibited the HG-induced increased FN synthesis.	Arginine	72-75	RAP1B, member of RAS oncogene family	Rattus norvegicus	16-21
12196519-1	2002	The cationic amino acid transporter, Cat-1, is a high affinity transporter of the essential amino acids, arginine and lysine.	Arginine	105-113	solute carrier family 7 member 1	Homo sapiens	37-42
12438438-0	2002	Arginine: an unusual dietary requirement of pre-B lymphocytes?	Arginine	0-8	prolactin regulatory element binding	Homo sapiens	44-49
12513909-7	2002	Three-dimensional models of IL-22 and IL-10 receptor complexes suggest two receptor residues (Gly-44 and Arg-96) are largely responsible for the marked differences in ligand affinity observed for sIL-10R1 and sIL-22R vs. sIL-10R2.	Arginine	105-108	interleukin 22	Homo sapiens	28-33
12513909-7	2002	Three-dimensional models of IL-22 and IL-10 receptor complexes suggest two receptor residues (Gly-44 and Arg-96) are largely responsible for the marked differences in ligand affinity observed for sIL-10R1 and sIL-22R vs. sIL-10R2.	Arginine	105-108	interleukin 10	Homo sapiens	38-43
12374746-7	2002	We also provide functional evidence that arginine residues methylated by CARM1 play a critical role in GRIP-1-dependent transcriptional activation and in hormone-induced gene activation.	Arginine	41-49	coactivator associated arginine methyltransferase 1	Homo sapiens	73-78
12356298-9	2002	We show that arginine substitutions in the DRY motifs of the alpha(1B) adrenergic receptor (alpha(1B)-AR) and angiotensin II type 1A receptor (AT(1A)R) result in receptors that are uncoupled from G proteins, associated with beta-arrestins, and found localized in endocytic vesicles rather than at the plasma membrane in the absence of agonists.	Arginine	13-21	adrenoceptor alpha 1B	Homo sapiens	61-90
12242346-4	2002	An Arg to Trp mutation in a gene of unknown function, EFEMP1, is responsible for ML, indicating EFEMP1 may be important in drusen formation.	Arginine	3-6	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	54-60
12242346-4	2002	An Arg to Trp mutation in a gene of unknown function, EFEMP1, is responsible for ML, indicating EFEMP1 may be important in drusen formation.	Arginine	3-6	EGF containing fibulin extracellular matrix protein 1	Homo sapiens	96-102
12171910-0	2002	Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.	Arginine	0-8	signal transducer and activator of transcription 1	Homo sapiens	24-29
12171910-2	2002	Here we show that arginine methylation of STAT1 controls the rate of STAT1 dephosphorylation by modulating its interaction with PIAS1 and the nuclear tyrosine phosphatase TcPTP.	Arginine	18-26	signal transducer and activator of transcription 1	Homo sapiens	42-47
12171910-2	2002	Here we show that arginine methylation of STAT1 controls the rate of STAT1 dephosphorylation by modulating its interaction with PIAS1 and the nuclear tyrosine phosphatase TcPTP.	Arginine	18-26	signal transducer and activator of transcription 1	Homo sapiens	69-74
12171910-3	2002	Inhibition of STAT1 arginine methylation, or mutation of STAT1 Arg-31, results in a prolonged half-life of STAT1 tyrosine phosphorylation.	Arginine	20-28	signal transducer and activator of transcription 1	Homo sapiens	14-19
12171910-3	2002	Inhibition of STAT1 arginine methylation, or mutation of STAT1 Arg-31, results in a prolonged half-life of STAT1 tyrosine phosphorylation.	Arginine	63-66	signal transducer and activator of transcription 1	Homo sapiens	57-62
12171910-3	2002	Inhibition of STAT1 arginine methylation, or mutation of STAT1 Arg-31, results in a prolonged half-life of STAT1 tyrosine phosphorylation.	Arginine	63-66	signal transducer and activator of transcription 1	Homo sapiens	57-62
12171910-5	2002	Furthermore, inhibitors of arginine methylation require the presence of PIAS1 to exert their negative regulatory effect on the dephosphorylation of STAT1.	Arginine	27-35	signal transducer and activator of transcription 1	Homo sapiens	148-153
12197713-4	2002	This analysis provided, for the first time, the hydrogen exchange rate constants for Lys and Arg side chains in a protein and pointed to an internal catalysis of the N-terminal amino protons in BPTI by a salt bridge.	Arginine	93-96	spleen trypsin inhibitor I	Bos taurus	194-198
12176067-7	2002	Methylated arginine (residue 108 equine) was found as both the mono- and the dimethylated derivative and represents the first MS/MS evidence for this modification in any MBP.	Arginine	11-19	myelin basic protein	Equus caballus	170-173
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Arginine	33-36	mucin 12, cell surface associated	Homo sapiens	206-211
12027806-6	2002	A similar cleavage sequence (Phe-Arg-Pro-Gly downward arrow Ser-Val-Val-Val, where downward arrow signifies the cleavage site) has been reported in human MUC1 and analogous sites are present in human MUC3, MUC12 and MUC17.	Arginine	33-36	mucin 17, cell surface associated	Homo sapiens	216-221
12045190-7	2002	Reporter gene analysis showed that single mutations of Arg(220) to Ala and Thr(232) to either Val or Ala increased the relative luciferase activities, which suggests that these specific amino acids, Arg(220) and Thr(232), in the i3 loop of MC4R play crucial roles in G-protein coupling and the subtype-specific signaling pathways.	Arginine	55-58	melanocortin 4 receptor	Homo sapiens	240-244
12186556-10	2002	Instead, the data are consistent with the formation of an enamine between the aldehyde group of the inhibitor and the guanidine group of Arg-221 in the PTP1B active site.	Arginine	137-140	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	152-157
12070169-4	2002	Site-directed mutagenesis revealed that the C-terminal region of arrestin-2 mediated beta(2)-adaptin and clathrin interaction with Phe-391 and Arg-395 having an essential role in beta(2)-adaptin binding and LIELD (residues 376-380) having an essential role in clathrin binding.	Arginine	143-146	adaptor related protein complex 2 subunit beta 1	Homo sapiens	179-194
12121764-2	2002	KatGs, CCP and APXs contain identical amino acid triads in the heme pocket (distal Arg/Trp/His and proximal His/Trp/Asp), but differ dramatically in their reactivities towards hydrogen peroxide and various one-electron donors.	Arginine	83-86	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	7-10
11983703-4	2002	Human kallikrein 6 has been proposed as the homologue to rat myelencephalon-specific protease, an arginine-specific degradative-type protease abundantly expressed in the central nervous system and implicated in demyelinating disease.	Arginine	98-106	kallikrein related peptidase 6	Homo sapiens	6-18
12093444-12	2002	The blood CD4(+):CD8(+) ratio was significantly higher in the Arg group than in the Gly group at 24 h after CLP.	Arginine	62-65	Cd4 molecule	Rattus norvegicus	10-13
12080468-6	2002	It is also shown that multiple signaling molecules, including PI3K, SHC, ras-GAP and CRK-L, are tyrosine phosphorylated in Ba/F3 cells that express ETV6/ARG.	Arginine	153-156	ets variant 6	Mus musculus	148-152
12080468-8	2002	Based upon these results it is concluded that ARG can be activated as an oncogene in human malignancy and that the ETV6/ARG oncoprotein triggers some of the same signaling pathways associated with activated ABL oncogenes.	Arginine	46-49	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	207-210
11896050-11	2002	The corresponding peptide was synthesized, and rMCP-4 was shown to cleave only the Phe-Arg bond in this peptide.	Arginine	87-90	mast cell protease 4	Rattus norvegicus	47-53
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	31-34	CD7 molecule	Homo sapiens	63-68
12009900-3	2002	In this study, analogues of Ac-Arg(6)-cyclo(S-S)(Cys(7)-Met(8)-Leu(9)-Gly(10)-Arg(11)-Val(12)-Tyr(13)-Arg(14)-Pro(15)-Cys(16))-NH(2), a high affinity but nonselective agonist at hMCH-1R and hMCH-2R, were prepared and tested in binding and functional assays on cells expressing these receptors.	Arginine	78-81	CD7 molecule	Homo sapiens	63-68
12054509-5	2002	A site-directed mutagenesis analysis of TIS11 NLS has revealed the critical importance of two arginine residues (Arg127 and Arg131 in the rat TIS11).	Arginine	94-102	zinc finger protein 36	Rattus norvegicus	40-45
12054509-5	2002	A site-directed mutagenesis analysis of TIS11 NLS has revealed the critical importance of two arginine residues (Arg127 and Arg131 in the rat TIS11).	Arginine	94-102	zinc finger protein 36	Rattus norvegicus	142-147
11884394-3	2002	Here, we report the genomic organization underlying the splice variants of DCLK and examine the expression profile of two splice variants affecting the kinase domain of DCLK and CPG16 (candidate plasticity gene 16), one containing an Arg-rich domain and the other affecting the C terminus of the protein.	Arginine	234-237	doublecortin like kinase 1	Homo sapiens	169-173
12108552-1	2002	We explored the unique substrate specificity of the primary S, subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from Phenylacetyl-Phe-Ser-Arg-EDDnp, a previously described inhibitor with analgesic and anti-inflammatory activities [Emim et al., Br.	Arginine	132-135	kallikrein related peptidase 4	Homo sapiens	88-98
12653475-3	2002	AGE-chromophores accumulate on long-lived skin proteins such as collagen and elastin as a consequence of glycation, the spontaneous amino-carbonyl reaction of protein-bound lysine and arginine residues with reactive carbonyl species.	Arginine	184-192	elastin	Homo sapiens	77-84
12133319-13	2002	(3) MMP-2 and TIMP-1 mRNA levels in the L-arginine group and the asthmatic group were significantly higher than that in the control group [L-arginine group (0.82 +/- 0.11), (0.51 +/- 0.12); asthmatic group (0.68 +/- 0.14), (0.56 +/- 0.10); control group (0.14 +/- 0.03), (0.11 +/- 0.05), respectively].	Arginine	40-50	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	14-20
12133319-16	2002	(4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P &lt; 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P &gt; 0.05).	Arginine	111-121	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	268-274
11867203-3	2002	A recent case-control study of SCCHN reported associations with two polymorphisms of the XRCC1 including the exon 6, 194Arg/Arg genotype and the exon 10, 399 Gln/Gln genotype.	Arginine	120-123	X-ray repair cross complementing 1	Homo sapiens	89-94
11973601-11	2002	(2) The number of nNOS positive neurons in VSMd and CPA were 2K1C+Arg &gt; 2K1C &gt;2K1C +NAME &gt; sham.	Arginine	66-69	nitric oxide synthase 1	Rattus norvegicus	18-22
11973601-12	2002	(3) L-Arg enhanced the expression of nNOS whereas L-NAME inhibited the expression of nNOS in caudal medulla.	Arginine	4-9	nitric oxide synthase 1	Rattus norvegicus	37-41
12062410-2	2002	The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment.	Arginine	208-216	von Willebrand factor A domain containing 1	Mus musculus	22-26
11960002-6	2002	Through positional and candidate gene cloning approaches we identified a nonsense mutation in the gata1 gene, 1015C --&gt; T (Arg-339 --&gt; Stop), in vlt(m651).	Arginine	126-129	GATA binding protein 1a	Danio rerio	98-103
12021143-3	2002	HLA genotyping identified several polymorphic residues of the DQalpha and DQbeta to be either positively or negatively associated with IDDM, including Arg 52 DQalpha and Asp 57 DQbeta.	Arginine	151-154	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	74-80
11922755-8	2002	The best recovery of refolded recombinant alpha-TTP fusion capable of binding alpha-tocopherol was provided by matrix-assisted refolding in the presence of 0.5 M arginine.	Arginine	162-170	alpha tocopherol transfer protein	Homo sapiens	42-51
11943176-2	2002	Here, we studied in vitro the kinetics of this cleavage by hSKI-1 using an intramolecularly quenched fluorogenic (IQF) peptide, Q-GPC(251-263) [Abz-(251)Asp-Ile-Tyr-Ile-Ser-Arg-Arg-Leu-Leu/Gly-Thr-Phe-Thr(263)-3-NitroTyr-Ala-CONH(2)], containing the identified site.	Arginine	173-176	membrane bound transcription factor peptidase, site 1	Homo sapiens	59-65
11751879-7	2002	The recognition of the Arg residue by HSP47 was specific to its side-chain structure because replacement of the Arg residue by other basic amino acids decreased the affinity to HSP47.	Arginine	23-26	serpin family H member 1	Homo sapiens	177-182
11751879-7	2002	The recognition of the Arg residue by HSP47 was specific to its side-chain structure because replacement of the Arg residue by other basic amino acids decreased the affinity to HSP47.	Arginine	112-115	serpin family H member 1	Homo sapiens	38-43
11751879-7	2002	The recognition of the Arg residue by HSP47 was specific to its side-chain structure because replacement of the Arg residue by other basic amino acids decreased the affinity to HSP47.	Arginine	112-115	serpin family H member 1	Homo sapiens	177-182
11751879-8	2002	The significance of Arg residues in HSP47 binding was further confirmed by using residue-specific chemical modification of types I and III collagen.	Arginine	20-23	serpin family H member 1	Homo sapiens	36-41
11751879-9	2002	Our results demonstrate that Xaa-Arg-Gly sequences in the triple-helical procollagen molecule are dominant binding sites for HSP47 and enable us to predict HSP47-binding sites in homotrimeric procollagen molecules.	Arginine	33-36	serpin family H member 1	Homo sapiens	125-130
11751879-9	2002	Our results demonstrate that Xaa-Arg-Gly sequences in the triple-helical procollagen molecule are dominant binding sites for HSP47 and enable us to predict HSP47-binding sites in homotrimeric procollagen molecules.	Arginine	33-36	serpin family H member 1	Homo sapiens	156-161
11823543-10	2002	One of the D3 epitopes (RGRGRGMGR) has significant sequence homology with a major antigenic region of Sm D1 (containing a carboxyl-terminal glycine-arginine repeat), and anti-D3 Abs cross-react with this epitope of Sm D1.	Arginine	148-156	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	102-107
11698398-2	2002	ASL is part of the urea and arginine-citrulline cycles and catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate.	Arginine	28-36	argininosuccinate lyase	Homo sapiens	0-3
11809802-7	2002	Mutations at an invariant arginine (Arg-131) within a second conserved structural motif known as the 5Y-CAP domain, as well as three other mutations (E235A, F260R, and D290A), caused marked changes in the DSB pattern at a recombination hotspot, suggesting that Spo11p contributes directly to the choice of DNA cleavage site.	Arginine	26-34	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	261-267
11809802-7	2002	Mutations at an invariant arginine (Arg-131) within a second conserved structural motif known as the 5Y-CAP domain, as well as three other mutations (E235A, F260R, and D290A), caused marked changes in the DSB pattern at a recombination hotspot, suggesting that Spo11p contributes directly to the choice of DNA cleavage site.	Arginine	36-39	DNA topoisomerase (ATP-hydrolyzing)	Saccharomyces cerevisiae S288C	261-267
11906459-2	2002	We have shown that exogenously administered L-arginine protects against water immersion restraint (WIR) stress-induced gastric mucosal lesions in rats through preservation of nitric oxide (NO) generation via constitutive nitric oxide synthase (cNOS), but not inducible nitric oxide synthase (iNOS), in the gastric mucosa.	Arginine	44-54	nitric oxide synthase 3	Rattus norvegicus	244-248
11906459-4	2002	Therefore, in the presesnt study, we examined whether exogenously administered L-arginine exerts a protective effect against WIR stress-induced gastric mucosal lesions in rats through preservation of gastric mucus synthesis and secretion by NO generated from the administered amino acid via cNOS in the gastric mucosa.	Arginine	79-89	nitric oxide synthase 3	Rattus norvegicus	291-295
11906459-11	2002	Pretreatment with L-arginine, but not D-arginine, attenuated decreases in hexosamine and adherent mucus concentrations and cNOS activity and increases in total NOS and iNOS activities and nitrite/nitrate concentration in the gastric mucosal tissue of rats subjected to WIR stress for 3 and 6 h in a dose-dependent manner.	Arginine	18-28	nitric oxide synthase 3	Rattus norvegicus	123-127
11787865-4	2002	DNA studies indicate that the mutation was G6PD Guadalajara 1159 C --&gt; T (387 Arg --&gt; Cys) that is situated at the NADP binding site.	Arginine	81-84	glucose-6-phosphate dehydrogenase	Homo sapiens	43-47
11749807-5	2001	Selective nNOS inhibitor 7-NI (5 nmol) icv could inhibit the induction of perforant path-dentate gyrus LTP elicited by Rg1 (P&lt;0.05), and L-arginine 250 g/L ip prevented the action of 7-nitroindazole (P&lt;0.05).	Arginine	140-150	nitric oxide synthase 1	Rattus norvegicus	10-14
11754414-7	2001	DNA sequencing analysis revealed a novel heterozygous missense mutation in the GPIb beta gene that converts Arg (CGC) to Cys (TGC) at residue 17.	Arginine	108-111	glycoprotein Ib platelet subunit alpha	Homo sapiens	79-88
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Arginine	58-61	CD47 molecule	Homo sapiens	175-202
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Arginine	58-61	CD47 molecule	Homo sapiens	204-207
11719373-1	2001	A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47.	Arginine	58-61	CD47 molecule	Homo sapiens	233-237
11713266-3	2001	SMN binds preferentially and directly to the symmetrical dimethylarginine (sDMA)-modified arginine- and glycine-rich (RG-rich) domains of SmD1 and SmD3.	Arginine	65-73	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	138-142
11708926-4	2001	Inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (SGF) relative to 1, allowing for the incorporation of lipophilic P1" side chains which had the effect of retaining potent TACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall selectivity against MMP1, MMP3, and MMP9.	Arginine	28-36	matrix metallopeptidase 3	Rattus norvegicus	363-367
11708926-4	2001	Inhibitors containing these arginine mimetics were found to have increased solubility in simulated gastric fluid (SGF) relative to 1, allowing for the incorporation of lipophilic P1" side chains which had the effect of retaining potent TACE inhibition, but reducing potency against matrix metalloproteases (MMPs) thus increasing overall selectivity against MMP1, MMP3, and MMP9.	Arginine	28-36	matrix metallopeptidase 9	Rattus norvegicus	373-377
11678642-6	2001	Intracellular L-arginine levels were higher in RMVEC vs RMAEC and well above the eNOS Km in both cell types.	Arginine	14-24	nitric oxide synthase 3	Rattus norvegicus	81-85
11746604-4	2001	L-[(14)C]citrulline uptake measurements confirmed that suppressor mutations in CAN1 conferred uptake of this amino acid, while none of the mutant permeases had lost the ability to transport L-[(14)C]arginine.	Arginine	199-207	arginine permease CAN1	Saccharomyces cerevisiae S288C	79-83
11557524-6	2001	These results suggest that the presence of the cationic charge at Arg-586 and Arg-1096 in rat MRP2 prevents the transport of TC, whereas the presence of neutral amino acids at the corresponding position of rat MRP3 is required for the transport of substrates.	Arginine	66-69	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98
11557524-6	2001	These results suggest that the presence of the cationic charge at Arg-586 and Arg-1096 in rat MRP2 prevents the transport of TC, whereas the presence of neutral amino acids at the corresponding position of rat MRP3 is required for the transport of substrates.	Arginine	78-81	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98
11679080-7	2001	The expression of several genes encoding enzymes in amino acid biosynthetic pathways, including the branched-chain, lysine and arginine, and the sulphur amino acid biosynthetic pathways, are modulated by Ssy1p.	Arginine	127-135	Ssy1p	Saccharomyces cerevisiae S288C	204-209
11496119-0	2001	Up-regulated eNOS protects blood-retinal barrier in the L-arginine treated ischemic rat retina.	Arginine	56-66	nitric oxide synthase 3	Rattus norvegicus	13-17
11496119-1	2001	Using immunoblot analysis and immunocytochemistry, we investigated expression and cellular localization of endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA) in the l-arginine treated ischemic rat retina.	Arginine	201-211	nitric oxide synthase 3	Rattus norvegicus	107-140
11496119-1	2001	Using immunoblot analysis and immunocytochemistry, we investigated expression and cellular localization of endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA) in the l-arginine treated ischemic rat retina.	Arginine	201-211	nitric oxide synthase 3	Rattus norvegicus	142-146
11496119-1	2001	Using immunoblot analysis and immunocytochemistry, we investigated expression and cellular localization of endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA) in the l-arginine treated ischemic rat retina.	Arginine	201-211	proliferating cell nuclear antigen	Rattus norvegicus	152-186
11496119-1	2001	Using immunoblot analysis and immunocytochemistry, we investigated expression and cellular localization of endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA) in the l-arginine treated ischemic rat retina.	Arginine	201-211	proliferating cell nuclear antigen	Rattus norvegicus	188-192
11496119-3	2001	In the l-arginine-treated ischemic retina, the magnitude of the increased eNOS was higher, and PCNA was expressed in endothelial cells as well as in neurons in the inner retina during the whole experimental period.	Arginine	7-17	nitric oxide synthase 3	Rattus norvegicus	74-78
11496119-3	2001	In the l-arginine-treated ischemic retina, the magnitude of the increased eNOS was higher, and PCNA was expressed in endothelial cells as well as in neurons in the inner retina during the whole experimental period.	Arginine	7-17	proliferating cell nuclear antigen	Rattus norvegicus	95-99
11387337-6	2001	Through site-directed mutagenesis, we defined the ERK/p38-binding site as a cluster of arginine residues in the NH(2)-terminal domain of MKP-2.	Arginine	87-95	dual specificity phosphatase 4	Homo sapiens	137-142
11387442-4	2001	PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo.	Arginine	30-38	protein arginine methyltransferase 1	Homo sapiens	0-5
11387442-4	2001	PRMT1 specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo.	Arginine	42-45	protein arginine methyltransferase 1	Homo sapiens	0-5
11387442-5	2001	Methylation of Arg 3 by PRMT1 facilitates subsequent acetylation of H4 tails by p300.	Arginine	15-18	protein arginine methyltransferase 1	Homo sapiens	24-29
11470919-1	2001	Arginase, which exists as the isoforms arginase I and II, catalyzes the hydrolysis of arginine to ornithine and urea.	Arginine	86-94	arginase 2	Rattus norvegicus	39-56
11400117-7	2001	After adjustment with other environmental confounders, the OR for the genotype of XRCC1399 Arg/Arg was 2.78 (95% CI =1.15-6.67) as compared with the XRCC1(399) Arg/Gln and XRCC1(399) Gln/Gln genotypes in the alcohol drinkers.	Arginine	91-94	X-ray repair cross complementing 1	Homo sapiens	82-87
11400117-7	2001	After adjustment with other environmental confounders, the OR for the genotype of XRCC1399 Arg/Arg was 2.78 (95% CI =1.15-6.67) as compared with the XRCC1(399) Arg/Gln and XRCC1(399) Gln/Gln genotypes in the alcohol drinkers.	Arginine	95-98	X-ray repair cross complementing 1	Homo sapiens	82-87
11400117-7	2001	After adjustment with other environmental confounders, the OR for the genotype of XRCC1399 Arg/Arg was 2.78 (95% CI =1.15-6.67) as compared with the XRCC1(399) Arg/Gln and XRCC1(399) Gln/Gln genotypes in the alcohol drinkers.	Arginine	95-98	X-ray repair cross complementing 1	Homo sapiens	82-87
11461075-0	2001	Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer.	Arginine	70-73	steroid receptor RNA activator 1	Homo sapiens	19-24
11457509-7	2001	Our work suggests that CAT2(B) may play a role in case of increased NO production as well as arginine or creatine deficiency in the brain.	Arginine	93-101	solute carrier family 7 member 2	Rattus norvegicus	23-30
11433300-2	2001	We also show that an Arg-to-Gln mutation in the PX domain of p47phox, which is found in patients with chronic granulomatous disease, eliminates phosphoinositide binding, as does the analogous mutation in the PX domain of p40phox.	Arginine	21-24	neutrophil cytosolic factor 1	Homo sapiens	61-68
11325964-1	2001	Neuronal nitric oxide synthase (nNOS) is composed of an oxygenase domain that binds heme, (6R)-tetrahydrobiopterin, and Arg, coupled to a reductase domain that binds FAD, FMN, and NADPH.	Arginine	120-123	nitric oxide synthase 1	Rattus norvegicus	0-30
11325964-1	2001	Neuronal nitric oxide synthase (nNOS) is composed of an oxygenase domain that binds heme, (6R)-tetrahydrobiopterin, and Arg, coupled to a reductase domain that binds FAD, FMN, and NADPH.	Arginine	120-123	nitric oxide synthase 1	Rattus norvegicus	32-36
11412100-3	2001	Substitution in Ira2p of the arginine following the arginine finger with alanine, the residue found in the corresponding position of p120-GAP, or by glycine as found in neurofibromin, evokes a low but significant stimulation of Ha-Ras GTPase.	Arginine	29-37	Ras GTPase activating protein IRA2	Saccharomyces cerevisiae S288C	16-21
11412100-4	2001	The stimulatory activity of Ira2p on Ha-Ras increased by substituting segments of the finger loop region with p120-GAP residues, especially with the six residues forming the tip of the arginine loop.	Arginine	185-193	Ras GTPase activating protein IRA2	Saccharomyces cerevisiae S288C	28-33
11412813-3	2001	The B2AR polymorphism of interest involves a single nucleotide change from A to G, resulting in an amino acid change from Arginine (Arg) to Glycine (Gly).	Arginine	122-130	adrenoceptor beta 2	Homo sapiens	4-8
11412813-3	2001	The B2AR polymorphism of interest involves a single nucleotide change from A to G, resulting in an amino acid change from Arginine (Arg) to Glycine (Gly).	Arginine	122-125	adrenoceptor beta 2	Homo sapiens	4-8
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Arginine	226-229	growth hormone receptor	Homo sapiens	12-35
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Arginine	226-229	growth hormone receptor	Homo sapiens	37-40
11371582-5	2001	Also, human growth hormone receptor (GHR) displays species specificity; i.e., it can interact only with human (or rhesus monkey) GH, not with nonprimate GHS: The species specificity of human GHR is largely due to the Leu--&gt;Arg change at position 43, and it has been hypothesized that this change must have been preceded by the His--&gt;Asp change at position 171 of GH.	Arginine	226-229	growth hormone receptor	Homo sapiens	191-194
11442002-3	2001	The mutated paternal allele has the substitution of His (CAC) in place of Arg (CGC) at codon 450 (R450H) of the TSH receptor.	Arginine	74-77	thyroid stimulating hormone receptor	Homo sapiens	112-124
11150296-0	2001	Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.	Arginine	0-8	signal transducer and activator of transcription 1	Homo sapiens	92-97
11150296-6	2001	In the three-dimensional structure of STAT1, we observed a structural arginine/lysine-rich element within the DNA-binding domain of the molecule.	Arginine	70-78	signal transducer and activator of transcription 1	Homo sapiens	38-43
11343794-2	2001	Bz-F-R-MCA was the best substrate for cathepsin B but also hydrolyzed Bz-R-R-MCA with lower efficiency, since the protease accepts Arg at S(2) due to the presence of Glu(245) at the bottom of this subsite.	Arginine	131-134	cathepsin B	Homo sapiens	38-49
11370664-1	2001	Human type II arginase, which is extrahepatic and mitochondrial in location, catalyzes the hydrolysis of arginine to form ornithine and urea.	Arginine	105-113	arginase 2	Homo sapiens	6-22
11370664-5	2001	The Km of arginine for type II arginase is approximately 4.8 mM at physiological pH.	Arginine	10-18	arginase 2	Homo sapiens	23-39
11410419-0	2001	Alpha128 Arg--&gt;Ser (CGT--&gt;AGT) spectrin mutation associated with severe neonatal elliptopoikilocytosis in Spain.	Arginine	9-12	UDP glycosyltransferase 8	Homo sapiens	23-26
11297694-3	2001	Here we show that the MHV-68 ORF74 is predicted to encode a GPCR since it has seven potential transmembrane helices and that it has other sequence motifs in common with GPCRS: Of interest is the observation that the sequence around a conserved arginine at the start of the second intracellular loop suggests that the ORF74 product may signal constitutively (agonist independent).	Arginine	244-252	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	60-64
11513478-6	2001	Furthermore, chemiluminescence was significantly increased and TRAP was significantly decreased in arginine-treated rats, whereas the simultaneous injection of L-NAME prevented these effects.	Arginine	99-107	acid phosphatase 5, tartrate resistant	Rattus norvegicus	63-67
11331301-1	2001	The P2Y(2) nucleotide receptor (P2Y(2)R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the possibility that this G protein-coupled receptor interacts directly with an integrin.	Arginine	78-86	purinergic receptor P2Y2	Homo sapiens	4-30
11331301-1	2001	The P2Y(2) nucleotide receptor (P2Y(2)R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the possibility that this G protein-coupled receptor interacts directly with an integrin.	Arginine	78-86	purinergic receptor P2Y2	Homo sapiens	32-39
11152678-6	2001	This protein is generated in the endoplasmic reticulum through N-terminal cleavage of pro-BDNF at the Arg-Gly-Leu-Thr(57)- downward arrow-Ser-Leu site.	Arginine	102-105	brain derived neurotrophic factor	Homo sapiens	90-94
11152687-6	2001	Unlike reported studies of other Fc Rgamma partners, these studies reveal that both the GPVI transmembrane arginine and intracellular C-tail are necessary for coupling to Fc Rgamma and for signal transduction.	Arginine	107-115	Fc epsilon receptor Ig	Rattus norvegicus	33-42
11152687-6	2001	Unlike reported studies of other Fc Rgamma partners, these studies reveal that both the GPVI transmembrane arginine and intracellular C-tail are necessary for coupling to Fc Rgamma and for signal transduction.	Arginine	107-115	Fc epsilon receptor Ig	Rattus norvegicus	171-180
11278590-9	2001	Most of the mutants showed impaired ability to reactivate PTL, with mutations in the Glu(64)/Arg(65) binding site causing the greatest effect.	Arginine	93-96	pancreatic lipase	Homo sapiens	58-61
11114306-2	2001	Amino acid starvation causes accumulation and increased translation of cat-1 mRNA, resulting in a 58-fold increase in protein levels and increased arginine uptake.	Arginine	147-155	solute carrier family 7 member 1	Homo sapiens	71-76
11247829-1	2001	Because L-arginine is degraded by hepatic arginase to ornithine and urea and is transported by the regulated 2A cationic amino acid y(+) transporter (CAT2A), hepatic transport may regulate plasma arginine concentration.	Arginine	8-18	solute carrier family 7 member 2	Rattus norvegicus	150-155
11247829-1	2001	Because L-arginine is degraded by hepatic arginase to ornithine and urea and is transported by the regulated 2A cationic amino acid y(+) transporter (CAT2A), hepatic transport may regulate plasma arginine concentration.	Arginine	10-18	solute carrier family 7 member 2	Rattus norvegicus	150-155
11247829-7	2001	This cannot be ascribed to changes in hepatic arginase expression but may be a consequence of increased hepatic arginine uptake via CAT2A.	Arginine	112-120	solute carrier family 7 member 2	Rattus norvegicus	132-137
11115503-3	2001	We previously showed that arginine, not simply a positive charge, at residue 3500 is essential for normal receptor binding and that the carboxyl terminus of apoB100 is necessary for mutations affecting arginine 3500 to disrupt LDL receptor binding.	Arginine	202-210	low density lipoprotein receptor	Mus musculus	227-239
11257227-0	2001	Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.	Arginine	0-8	signal transducer and activator of transcription 1	Homo sapiens	24-29
11257227-3	2001	Here we demonstrate arginine methylation of STAT1 by the protein arginine methyl-transferase PRMT1 as a novel requirement for IFNalpha/beta-induced transcription.	Arginine	20-28	signal transducer and activator of transcription 1	Homo sapiens	44-49
11257227-3	2001	Here we demonstrate arginine methylation of STAT1 by the protein arginine methyl-transferase PRMT1 as a novel requirement for IFNalpha/beta-induced transcription.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	93-98
11257227-6	2001	Thus, arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of arginine methylation might be responsible for the lack of interferon responsiveness observed in many malignancies.	Arginine	6-14	signal transducer and activator of transcription 1	Homo sapiens	30-35
11303590-2	2001	We examined the association of polymorphisms in XRCC1 (codon 194 Arg--&gt;Trp and codon 399 Arg--&gt;Gln) and breast cancer in the Carolina Breast Cancer Study, a population-based case-control study in North Carolina.	Arginine	65-68	X-ray repair cross complementing 1	Homo sapiens	48-53
11303590-4	2001	A positive association for XRCC1 codon 399 Arg/Gln or Gln/Gln genotypes compared with Arg/Arg was found among African Americans (253 cases, 266 controls; OR = 1.7, 95% confidence interval, 1.1-2.4) but not whites (386 cases, 381 controls; OR =1.0, 95% confidence interval, 0.8-1.4).	Arginine	43-46	X-ray repair cross complementing 1	Homo sapiens	27-32
11303590-4	2001	A positive association for XRCC1 codon 399 Arg/Gln or Gln/Gln genotypes compared with Arg/Arg was found among African Americans (253 cases, 266 controls; OR = 1.7, 95% confidence interval, 1.1-2.4) but not whites (386 cases, 381 controls; OR =1.0, 95% confidence interval, 0.8-1.4).	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	27-32
11303590-4	2001	A positive association for XRCC1 codon 399 Arg/Gln or Gln/Gln genotypes compared with Arg/Arg was found among African Americans (253 cases, 266 controls; OR = 1.7, 95% confidence interval, 1.1-2.4) but not whites (386 cases, 381 controls; OR =1.0, 95% confidence interval, 0.8-1.4).	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	27-32
11303590-5	2001	Among African-American women, ORs for the duration of smoking were elevated among women with XRCC1 codon 399 Arg/Arg genotype (trend test; P &lt; 0.001) but not Arg/Gln or Gln/Gln (P = 0.23).	Arginine	109-112	X-ray repair cross complementing 1	Homo sapiens	93-98
11303590-5	2001	Among African-American women, ORs for the duration of smoking were elevated among women with XRCC1 codon 399 Arg/Arg genotype (trend test; P &lt; 0.001) but not Arg/Gln or Gln/Gln (P = 0.23).	Arginine	113-116	X-ray repair cross complementing 1	Homo sapiens	93-98
11303590-5	2001	Among African-American women, ORs for the duration of smoking were elevated among women with XRCC1 codon 399 Arg/Arg genotype (trend test; P &lt; 0.001) but not Arg/Gln or Gln/Gln (P = 0.23).	Arginine	113-116	X-ray repair cross complementing 1	Homo sapiens	93-98
11303590-8	2001	High-dose radiation to the chest was more strongly associated with breast cancer among white women with XRCC1 codon 399 Arg/Arg genotype.	Arginine	120-123	X-ray repair cross complementing 1	Homo sapiens	104-109
11303590-8	2001	High-dose radiation to the chest was more strongly associated with breast cancer among white women with XRCC1 codon 399 Arg/Arg genotype.	Arginine	124-127	X-ray repair cross complementing 1	Homo sapiens	104-109
11327858-10	2001	The repeated motif contains Arg residues spaced by a hydrophobic segment that may be involved in Hdm2 recognition and binding.	Arginine	28-31	MDM2 proto-oncogene	Homo sapiens	97-101
11245460-7	2001	Animals transplanted with transgenic Arg-22 DHFR drug-resistant marrow maintained hematocrit levels that were about 4-fold higher at 3 weeks after transplant than those of untreated animals or animals that received normal marrow cells.	Arginine	37-40	dihydrofolate reductase	Mus musculus	44-48
11462974-0	2001	Design, synthesis, and modeling of novel cyclic thrombin receptor-derived peptide analogues of the Ser42-Phe-Leu-Leu-Arg46 motif sequence with fixed conformations of pharmacophoric groups: importance of a Phe/Arg/NH2 cluster for receptor activation and implications in the design of nonpeptide thrombin receptor mimetics.	Arginine	117-120	coagulation factor II (thrombin) receptor	Rattus norvegicus	48-65
11166181-7	2001	Secondly, eIF5 possesses a conserved arginine (Arg15) which, like the "arginine fingers" of classical GAPs, is flanked by hydrophobic residues.	Arginine	37-45	eukaryotic translation initiation factor 5	Homo sapiens	10-14
11166181-7	2001	Secondly, eIF5 possesses a conserved arginine (Arg15) which, like the "arginine fingers" of classical GAPs, is flanked by hydrophobic residues.	Arginine	71-79	eukaryotic translation initiation factor 5	Homo sapiens	10-14
11166181-9	2001	Mutation studies suggest that a second conserved arginine (Arg48) also contributes to the GTPase active site of the eIF2.eIF5 complex.	Arginine	49-57	eukaryotic translation initiation factor 5	Homo sapiens	121-125
11020389-6	2001	Practically all bound H(4)B was oxidized to a radical during the reaction and was associated with hydroxylation of 0.6 mol of Arg/mol of heme.	Arginine	126-129	H4 clustered histone 4	Homo sapiens	22-27
11020389-8	2001	These results establish kinetic and quantitative links among ferrous-dioxy disappearance, H(4)B oxidation, and Arg hydroxylation and suggest a mechanism whereby H(4)B transfers an electron to the ferrous-dioxy intermediate to enable the formation of a heme-based oxidant that rapidly hydroxylates Arg.	Arginine	111-114	H4 clustered histone 4	Homo sapiens	161-166
11020389-8	2001	These results establish kinetic and quantitative links among ferrous-dioxy disappearance, H(4)B oxidation, and Arg hydroxylation and suggest a mechanism whereby H(4)B transfers an electron to the ferrous-dioxy intermediate to enable the formation of a heme-based oxidant that rapidly hydroxylates Arg.	Arginine	297-300	H4 clustered histone 4	Homo sapiens	161-166
11104903-3	2001	A nucleotide substitution of guanine to adenine leading to a non-conservative amino acid change was identified in the XRCC1 gene at codon 399 (Arg/Gln).	Arginine	143-146	X-ray repair cross complementing 1	Homo sapiens	118-123
11104903-10	2001	Among controls, XRCC1 allele frequencies were 45.5% for Arg/Arg, 44.8% for Arg/Gln, and 9.8% for Gln/Gln.	Arginine	56-59	X-ray repair cross complementing 1	Homo sapiens	16-21
11104903-10	2001	Among controls, XRCC1 allele frequencies were 45.5% for Arg/Arg, 44.8% for Arg/Gln, and 9.8% for Gln/Gln.	Arginine	60-63	X-ray repair cross complementing 1	Homo sapiens	16-21
11104903-10	2001	Among controls, XRCC1 allele frequencies were 45.5% for Arg/Arg, 44.8% for Arg/Gln, and 9.8% for Gln/Gln.	Arginine	60-63	X-ray repair cross complementing 1	Homo sapiens	16-21
11842279-5	2001	In a Turkish proband, an arginine (CGT) to cysteine (TGT) substitution at amino acid position 116 was identified.	Arginine	25-33	UDP glycosyltransferase 8	Homo sapiens	35-38
11374781-3	2001	A mutation in the MSX1 gene, detected in a single family, resulting in an Arg--&gt;Pro substitution in the homeodomain of the protein product of this gene has previously been associated with the deficiency of second premolars and third molars.	Arginine	74-77	msh homeobox 1	Homo sapiens	18-22
11306963-4	2001	RESULTS: During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF).	Arginine	70-78	adrenoceptor beta 2	Homo sapiens	92-102
11306963-4	2001	RESULTS: During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF).	Arginine	80-83	adrenoceptor beta 2	Homo sapiens	92-102
11306963-4	2001	RESULTS: During the 16-week treatment period, patients homozygous for arginine (Arg/Arg) at beta(2)-AR-16 who used albuterol regularly had a small decline in morning peak expiratory flow (AM PEF).	Arginine	84-87	adrenoceptor beta 2	Homo sapiens	92-102
12230267-1	2001	We aimed to show whether the administration of exogenous L-Arg would alter the morphological, functional changes and interaction of nitric oxide and cell adhesion molecules such as tenascin and lectin after release of twenty-four hours complete ureteric obstruction in the solitary rat kidney tissue.	Arginine	57-62	tenascin C	Rattus norvegicus	181-189
12230267-15	2001	In L-Arg group, tenascin and lectin expression was moderate in tubulus membrane.	Arginine	3-8	tenascin C	Rattus norvegicus	16-24
11277076-7	2001	Pro--&gt;Arg substitutions equivalent the Pro253Arg/FGFR2 mutation occur in both FGFR1 and FGFR3, and are also associated with craniosynostosis.	Arginine	9-12	fibroblast growth factor receptor 3	Homo sapiens	91-96
11150170-10	2000	In general, the trend is that D-amino acid substitutions of the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10), but not Arg(7), result in an increase in MC3R selectivity over the MC4R and MC5R and only agonist activity is observed.	Arginine	120-123	melanocortin 4 receptor	Homo sapiens	196-200
11150170-10	2000	In general, the trend is that D-amino acid substitutions of the aromatic residues 1, 6, 8, and 11 and the basic residue Arg(10), but not Arg(7), result in an increase in MC3R selectivity over the MC4R and MC5R and only agonist activity is observed.	Arginine	120-123	melanocortin 5 receptor	Homo sapiens	205-209
11197692-1	2000	We recently reported the association of the allele coding for Arg at the position 196 (196R: nucleotide [nt] 587G) of tumor necrosis factor receptor 2 (TNFR2, TNF-R75) with systemic lupus erythematosus (SLE) in Japanese.	Arginine	62-65	TNF receptor superfamily member 1B	Homo sapiens	118-150
11197692-1	2000	We recently reported the association of the allele coding for Arg at the position 196 (196R: nucleotide [nt] 587G) of tumor necrosis factor receptor 2 (TNFR2, TNF-R75) with systemic lupus erythematosus (SLE) in Japanese.	Arginine	62-65	TNF receptor superfamily member 1B	Homo sapiens	152-157
11197692-1	2000	We recently reported the association of the allele coding for Arg at the position 196 (196R: nucleotide [nt] 587G) of tumor necrosis factor receptor 2 (TNFR2, TNF-R75) with systemic lupus erythematosus (SLE) in Japanese.	Arginine	62-65	TNF receptor superfamily member 1B	Homo sapiens	159-166
24383644-4	2000	We report a case of Behcet"s disease associated with complete C9 deficiency (C9D) carrying the homozygous nonsense mutation at Arg-95 of C9 (R95X).	Arginine	127-130	complement C9	Homo sapiens	62-64
11063591-8	2000	Residues Val-1, Arg-7, and Lys-9 of V1 peptide were found to be critical for receptor interaction, because single alanine replacement at these positions dramatically decreased peptide binding to CXCR4.	Arginine	16-19	C-X-C motif chemokine receptor 4	Homo sapiens	195-200
10926932-0	2000	Mutation of arginine 44 of GAT-1, a (Na(+) + Cl(-))-coupled gamma-aminobutyric acid transporter from rat brain, impairs net flux but not exchange.	Arginine	12-20	solute carrier family 6 member 12	Rattus norvegicus	27-32
10992236-1	2000	A novel chemo-enzymatic synthesis of arginine-based gemini cationic surfactants bis(Args) is reported.	Arginine	37-45	serpin family A member 2 (gene/pseudogene)	Homo sapiens	84-88
11113887-1	2000	Prenatal diagnosis was performed in a family where the father has osteogenesis imperfecta (OI) type I, with a novel mutation in the COL1A1 gene: a C to T change at position c3076 (c.3076C--&gt;T) leading to a change of arginine at codon 848 to a stop codon (R848X).	Arginine	219-227	collagen type I alpha 1 chain	Homo sapiens	132-138
11369259-3	2000	Moreover, certain basic residues of this site, particularly Arg(165) and Lys(169), play a key role in factor Va and/or prothrombin recognition by factor Xa in the prothrombinase complex.	Arginine	60-63	coagulation factor X	Homo sapiens	146-155
11024268-0	2000	Regulation of anaerobic arginine catabolism in Bacillus licheniformis by a protein of the Crp/Fnr family.	Arginine	24-32	catabolite gene activator protein	Escherichia coli	90-93
11024268-5	2000	Residues in the C-terminal domain of Crp that form the DNA binding motif, in particular residues Arg-180 and Glu-181 that make specific bonds with DNA, are conserved in ArcR, suggesting that the complexes formed with DNA by Crp and ArcR are similar.	Arginine	97-100	catabolite gene activator protein	Escherichia coli	37-40
11024268-5	2000	Residues in the C-terminal domain of Crp that form the DNA binding motif, in particular residues Arg-180 and Glu-181 that make specific bonds with DNA, are conserved in ArcR, suggesting that the complexes formed with DNA by Crp and ArcR are similar.	Arginine	97-100	catabolite gene activator protein	Escherichia coli	224-227
10900194-7	2000	The A and B beta-strands of the N-terminal domain of TIMP-3 contain two potential heparin-binding sequences rich in lysine and arginine; these strands should form a double track on the outer surface of TIMP-3.	Arginine	127-135	TIMP metallopeptidase inhibitor 3	Homo sapiens	53-59
10900194-7	2000	The A and B beta-strands of the N-terminal domain of TIMP-3 contain two potential heparin-binding sequences rich in lysine and arginine; these strands should form a double track on the outer surface of TIMP-3.	Arginine	127-135	TIMP metallopeptidase inhibitor 3	Homo sapiens	202-208
10913131-5	2000	One corresponds to a canonical Grb2-binding motif, whereas the second, located within the Gab1 Met-binding domain, requires the proline and arginine residues of an atypical PXXXR motif.	Arginine	140-148	GRB2 associated binding protein 1	Homo sapiens	90-94
11013213-6	2000	The conserved and catalytically crucial arginine residue, identified by mutational analysis, is in a comparable position to the arginine finger in the Ras- and Cdc42-GAPs, suggesting that Gyp1p utilizes an arginine finger in the GAP reaction, in analogy to Ras- and Cdc42-GAPs.	Arginine	40-48	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	266-271
10970698-0	2000	[Arg(6), D-Trp(7,9), N(me)Phe(8)]-substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.	Arginine	1-4	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80
10998050-1	2000	A single mutation, involving the replacement of an arginine residue with histidine to reconstruct a zinc-binding site, suffices to change a catalytically inactive murine carbonic anhydrase-related protein (CARP) to an active carbonic anhydrase with a CO2-hydration turnover number of 1.2 x 104 s-1.	Arginine	51-59	carbonic anhydrase 8	Mus musculus	170-204
11022192-6	2000	RESULTS: We identified a novel heterozygous TSHR gene mutation, Leu512--&gt;Arg (L512R; CTG--&gt;CCG), from the AFTN.	Arginine	76-79	thyroid stimulating hormone receptor	Homo sapiens	44-48
11000246-4	2000	UV cross-linking experiments indicate that the lysine residue in the AX(4)GKS motif is directly involved in ATP binding, whereas the NS3(GR1490DT) mutant in which the arginine-rich motif (1486-QRRGRTGR-1493) was changed to QRRDTTGR bound ATP as well as the wild type.	Arginine	167-175	KRAS proto-oncogene, GTPase	Homo sapiens	133-136
11000246-5	2000	The binding activity of HCV NS3 helicase to the viral RNA was drastically reduced with the mutation at Arg1488 (R1488A) and was also affected by the K1236E substitution in the AX(4)GKS motif and the R1490A and GR1490DT mutations in the arginine-rich motif.	Arginine	236-244	KRAS proto-oncogene, GTPase	Homo sapiens	28-31
10978164-4	2000	The results suggest that, in addition to stabilizing the reactive intermediate compound I, the distal arginine plays an important role as a gatekeeper in the active site of CCP, controlling the access to the ferryl oxygen and the distal histidine.	Arginine	102-110	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	173-176
10951198-4	2000	Cathepsin X was similar to cathepsin B and found to be a carboxypeptidase with preference for a positively charged Arg in P1 position.	Arginine	115-118	cathepsin Z	Homo sapiens	0-11
10951198-4	2000	Cathepsin X was similar to cathepsin B and found to be a carboxypeptidase with preference for a positively charged Arg in P1 position.	Arginine	115-118	cathepsin B	Homo sapiens	27-38
10951198-6	2000	However, the preference for Arg in the P1 position is so strong that cathepsin X cleaves substrates with Arg in antepenultimate position, acting also as a carboxydipeptidase.	Arginine	28-31	cathepsin Z	Homo sapiens	69-80
10951198-6	2000	However, the preference for Arg in the P1 position is so strong that cathepsin X cleaves substrates with Arg in antepenultimate position, acting also as a carboxydipeptidase.	Arginine	105-108	cathepsin Z	Homo sapiens	69-80
10859319-6	2000	NH(2)-terminal amino acid sequencing revealed that MMP-12 cleaved TFPI at Lys(20)-Leu(21)(close to Kunitz I domain and producing a 35-kDa band), Arg(83)-Ile(84) (between Kunitz I and II domains), and Ser(174)-Thr(175) (between Kunitz II and III domains).	Arginine	145-148	matrix metallopeptidase 12	Homo sapiens	51-57
11334229-8	2000	L-arg abolished the hypertensive effect of the peptide given at the smallest dose, did not change the effect of secretin administered at the medium dose (which did not raise the pressure) and preserved the action of the highest secretin dose.	Arginine	0-5	secretin	Rattus norvegicus	228-236
11334230-12	2000	L-arg did not change the effect of secretin, however it abolished non significant decrease in coronary outflow evoked by the highest dose of secretin.	Arginine	0-5	secretin	Rattus norvegicus	141-149
10956021-2	2000	We previously reported that Cys-containing, Arg-rich peptide-substrate analogues spontaneously form disulfide-linked complexes with PKC isozymes, resulting in isozyme inactivation.	Arginine	44-47	protein kinase C, gamma	Rattus norvegicus	132-135
10811659-0	2000	Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase.	Arginine	14-23	carboxyl ester lipase	Rattus norvegicus	128-149
10811659-1	2000	Previous studies using chemical modification approach have shown the importance of arginine residues in bile salt activation of carboxyl ester lipase (CEL) activity.	Arginine	83-91	carboxyl ester lipase	Rattus norvegicus	128-149
10811659-1	2000	Previous studies using chemical modification approach have shown the importance of arginine residues in bile salt activation of carboxyl ester lipase (CEL) activity.	Arginine	83-91	carboxyl ester lipase	Rattus norvegicus	151-154
10811659-3	2000	The current study used a site-specific mutagenesis approach to determine the role of arginine residues 63 and 423 in bile salt-dependent and bile salt-independent hydrolytic activities of rat CEL.	Arginine	85-93	carboxyl ester lipase	Rattus norvegicus	192-195
10871864-5	2000	In contrast, we now report that the full length Sam68 protein having the same mutation (Arginine429--&gt;Alanine) is completely localized in the nucleus while another Sam68 (Proline439--&gt;Arginine) mutant is found in the cytoplasm.	Arginine	88-96	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	48-53
10811994-2	2000	Tumor and neovascular endothelial cells in squamous cell carcinoma have been reported to express integrin heterodimers containing the alphav subunit, which binds to vitronectin and other extracellular matrix proteins that contain the amino acid recognition sequence Arg-Gly-Asp (RGD).	Arginine	266-269	vitronectin	Mus musculus	165-176
10815158-3	2000	METHODS: Commercial tPA in L-arginine solution was injected into the mid vitreous cavity of normal cat eyes in doses of 25, 50, 75, and 100 microg/0.1 mL and 200 microg/0.2 mL.	Arginine	27-37	chromosome 20 open reading frame 181	Homo sapiens	20-23
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	34-42	glutathione S-transferase theta 1	Homo sapiens	262-267
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	glutathione S-transferase theta 1	Homo sapiens	92-97
10813720-6	2000	The individuals carrying both the arginine/proline genotype of p53 and the null genotype of GSTT1 showed a 3.5-fold increase of cervical carcinoma risk (95% CI, 1.8-7.1) compared with those individuals carrying both the arginine/arginine genotype of p53 and the GSTT1 positive genotype.	Arginine	220-228	glutathione S-transferase theta 1	Homo sapiens	92-97
10813720-9	2000	CONCLUSIONS: The results of the current study suggested that the arginine/proline genotype of p53, independently or in conjunction with the GSTT1 null genotype, could affect the genetic susceptibility for cervical carcinoma, and HPV positive women carrying both null genotypes of GSTT1 and GSTM1 have an increased risk of cervical carcinoma developing before age 40 years.	Arginine	65-73	glutathione S-transferase theta 1	Homo sapiens	280-285
10753927-0	2000	The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.	Arginine	96-104	Ras homolog, mTORC1 binding	Rattus norvegicus	29-33
10753927-6	2000	This increased arginine uptake requires the arginine-specific permease Can1p.	Arginine	15-23	arginine permease CAN1	Saccharomyces cerevisiae S288C	71-76
10727427-6	2000	Furthermore, down-regulation of cytokine-induced RANTES mRNA in keratinocytes was dependent on endogenously produced NO, as inhibition of the co-induced iNOS by L-N(G)-monomethyl-L-arginine increased cytokine-triggered RANTES expression in the cells.	Arginine	178-189	C-C motif chemokine ligand 5	Homo sapiens	49-55
10739955-5	2000	Amino acid number 12 of K-Ras (wild type; Gly) was changed to Ser, Arg, Cys, Asp, Ala, or Val, and the mobility shift of the greenish fluorescent bands in the SDS/urea gel was analyzed.	Arginine	67-70	KRAS proto-oncogene, GTPase	Homo sapiens	24-29
10733681-0	2000	arg-cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome.	Arginine	0-3	myosin VA	Homo sapiens	48-57
10734118-6	2000	In addition discrepancies in results of previous studies using chimeric IgE receptors comprising FcepsilonRIalpha with either FcgammaRIIa or FcgammaRIIIA can be explained by the presence or absence of Arg(15) and its influence on the IgE-binding site.	Arginine	201-204	Fc gamma receptor IIIa	Homo sapiens	141-153
10700017-9	2000	Administration of L-arginine before KA attenuated neuronal loss in CA3 but not CA1.	Arginine	18-28	carbonic anhydrase 3	Rattus norvegicus	67-70
10700017-10	2000	A clear protective effect was observed, however, in CA1 and CA3, in rats receiving both L-arginine plus 7-nitroindazole before KA.	Arginine	88-98	carbonic anhydrase 3	Rattus norvegicus	60-63
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	ataxin 3	Homo sapiens	82-86
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	88-92
10712199-2	2000	The mutant proteins have shown an expanded polyglutamine tract in SCA1, SCA2, MJD/SCA3, SCA6, SCA7, and DRPLA; a glycine-to-arginine substitution was found in SCA6 as well.	Arginine	124-132	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	159-163
10752624-4	2000	The increase is modest (threefold) for substrates specific for tPA that carry Pro or Gly at P2, but reaches 80-fold for less specific substrates carrying Arg at P2.	Arginine	154-157	chromosome 20 open reading frame 181	Homo sapiens	63-66
10639384-2	2000	The amino acid sequence deduced from the corresponding bla gene showed two amino acid replacements with respect to the TEM-2 sequence: Glu-104 to Lys and His-153 to Arg.	Arginine	165-168	TEM beta-lactamase	Klebsiella pneumoniae	55-58
10748356-13	2000	Myocardial release of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin were significantly less (p&lt;0.05) in the L-ARG group at 15 minutes of reperfusion.	Arginine	135-140	intercellular adhesion molecule 1	Rattus norvegicus	69-75
10748356-13	2000	Myocardial release of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin were significantly less (p&lt;0.05) in the L-ARG group at 15 minutes of reperfusion.	Arginine	135-140	selectin E	Rattus norvegicus	81-91
10648631-0	2000	Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.	Arginine	44-52	adrenoceptor alpha 1B	Homo sapiens	93-122
10648631-0	2000	Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.	Arginine	72-75	adrenoceptor alpha 1B	Homo sapiens	93-122
10705178-8	2000	L-Arg application enhanced NO release, and recovered the increase of NO by CCK-8.	Arginine	0-5	cholecystokinin	Cavia porcellus	75-78
10865936-7	2000	Acetylcholine (Ach)-induced vasodilation was significantly reduced in the CuD group both before and after pretreatment with the eNOS substrate L-arginine.	Arginine	143-153	nitric oxide synthase 3	Rattus norvegicus	128-132
10634367-2	2000	The acute insulin response to arginine was impaired in LADA vs. type 2 diabetes at all glucose levels, with the greatest impairment in the maximally stimulated insulin concentrations (P&lt;0.04).	Arginine	30-38	ladinin 1	Homo sapiens	55-59
10631259-7	2000	This inhibitory sequence appears to overlap with a calmodulin-binding site in ACA2, previously mapped between aspartate-19 and arginine-36 (J.F.	Arginine	127-135	Cst6p	Saccharomyces cerevisiae S288C	78-82
10668803-1	2000	Rpb5-H147R is an AT-GC transition replacing CAC(His) by CGC(Arg) at a conserved and critical position of ABC27 (Rpb5p), one of the five common and essential subunits shared by all three eukaryotic RNA polymerases.	Arginine	60-63	ATP binding cassette subfamily F member 1	Homo sapiens	105-110
10668804-1	2000	The SRm160/300 splicing coactivator, which consists of the serine/arginine (SR)-related nuclear matrix protein of 160 kDa and a 300-kDa nuclear matrix antigen, functions in splicing by promoting critical interactions between splicing factors bound to pre-mRNA, including snRNPs and SR family proteins.	Arginine	66-74	serine and arginine repetitive matrix 1	Homo sapiens	4-10
10593949-0	1999	Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine.	Arginine	150-158	polyglutamine binding protein 1	Homo sapiens	37-42
10593949-5	1999	The binding analysis using an oligopeptide-immobilized membrane revealed that the WW domain of Npw38 preferentially recognizes a short proline-rich sequence, PPGPPP, surrounded by an arginine residue, so we named it a PGR motif.	Arginine	183-191	polyglutamine binding protein 1	Homo sapiens	95-100
10587455-1	1999	The apolipoprotein A-IMilano (apoA-IM) is a molecular variant of apoA-I characterized by the Arg(173)--&gt;Cys substitution, resulting in the formation of homodimers A-IM/A-IM.	Arginine	93-96	apolipoprotein A-I	Mus musculus	30-36
10602474-1	1999	Dlk (also termed ZIP kinase) is a novel serine/threonine kinase with a unique C-terminal domain that is rich in arginine and contains three putative NLS motifs and a functional lecuine zipper.	Arginine	112-120	death associated protein kinase 3	Homo sapiens	0-3
10602474-1	1999	Dlk (also termed ZIP kinase) is a novel serine/threonine kinase with a unique C-terminal domain that is rich in arginine and contains three putative NLS motifs and a functional lecuine zipper.	Arginine	112-120	death associated protein kinase 3	Homo sapiens	17-27
10594405-9	1999	L-Arg did not affect postprandial pH and plasma hormones, but reversed L-NMMA-induced alterations in intragastric pH and in plasma gastrin and somatostatin levels.	Arginine	0-5	somatostatin	Homo sapiens	143-155
10567393-0	1999	Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain.	Arginine	132-140	FA complementation group A	Homo sapiens	90-95
10567393-5	1999	Site-directed mutagenesis of FANCA residues 18-29 revealed a novel arginine-rich interaction domain (RRRAWAELLAG).	Arginine	67-75	FA complementation group A	Homo sapiens	29-34
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	95-98	serum/glucocorticoid regulated kinase 2	Rattus norvegicus	19-23
10548550-9	1999	Like PKB and SGK1, SGK2 and SGK3 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs.	Arginine	103-106	serum/glucocorticoid regulated kinase 2	Rattus norvegicus	19-23
10542224-4	1999	Alanine-scanning analysis identified Phe(184), Arg(186), Leu(187), and Ile(190) as important determinants of maximum binding of (125)I-labeled bovine PTH-(1-34) and (125)I-labeled bovine PTH-(3-34) and determinants of responsiveness to the NH(2)-terminal analog, PTH-(1-14) in cAMP stimulation assays.	Arginine	47-50	parathyroid hormone	Bos taurus	150-153
10502303-5	1999	The consensus sequence for substrate phosphorylation was determined to be RXXSXR, which was partially distinct from mammalian p70(S6K) in its requirement for an amino-terminal arginine.	Arginine	176-184	annexin A6	Homo sapiens	126-129
10547195-5	1999	By using an automated DNA sequencer, a K-ras mutation (codon 12, GGT to CGT, Gly to Arg) was detected in the pancreatic tumor tissue taken from the patient, whereas no p53 mutation was detected.	Arginine	84-87	KRAS proto-oncogene, GTPase	Homo sapiens	39-44
10521420-12	1999	Finally, y(+)-mediated transport of arginine in amino acid-fed and -starved cells paralleled Cat-1 protein levels.	Arginine	36-44	solute carrier family 7 member 1	Homo sapiens	93-98
10516295-2	1999	RNA editing of the codon that encodes the glutamine/arginine (Q/R) site in the second membrane domain (MD2) of glutamate receptor 5 (GluR5) and GluR6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single-channel conductances.	Arginine	52-60	glutamate receptor, ionotropic, kainate 2 (beta 2)	Mus musculus	144-149
10532447-1	1999	OBJECTIVE: To report the phenotype associated with the codon 172 RDS (gene for retinal degeneration slow) mutation in 11 separate families with an arginine-to-tryptophan substitution with common ancestry, and 1 family with an arginine-to-glutamine transition.	Arginine	147-155	peripherin 2	Homo sapiens	65-68
10532447-1	1999	OBJECTIVE: To report the phenotype associated with the codon 172 RDS (gene for retinal degeneration slow) mutation in 11 separate families with an arginine-to-tryptophan substitution with common ancestry, and 1 family with an arginine-to-glutamine transition.	Arginine	147-155	peripherin 2	Homo sapiens	79-104
10532447-1	1999	OBJECTIVE: To report the phenotype associated with the codon 172 RDS (gene for retinal degeneration slow) mutation in 11 separate families with an arginine-to-tryptophan substitution with common ancestry, and 1 family with an arginine-to-glutamine transition.	Arginine	226-234	peripherin 2	Homo sapiens	65-68
10532447-1	1999	OBJECTIVE: To report the phenotype associated with the codon 172 RDS (gene for retinal degeneration slow) mutation in 11 separate families with an arginine-to-tryptophan substitution with common ancestry, and 1 family with an arginine-to-glutamine transition.	Arginine	226-234	peripherin 2	Homo sapiens	79-104
10545044-2	1999	The patient was heterozygous for a G-to-A substitution at codon 524 (R524Q), changing an encoded arginine (CGA) to glutamine (CAA), while the GBE1 gene on the other allele was not expressed.	Arginine	97-105	teashirt zinc finger homeobox 1	Homo sapiens	126-129
10554552-2	1999	Mutation of arginin to glutamine in codon 555 (R 555 Q) in kerato-epithelin was recently reported in four blood-related patients with Reis-Bucklers corneal dystrophy.	Arginine	12-19	transforming growth factor beta induced	Homo sapiens	59-75
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	119-122	zona pellucida glycoprotein 3	Mus musculus	77-81
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 3	Mus musculus	77-81
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 3	Mus musculus	77-81
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 3	Mus musculus	77-81
10493795-4	1999	Here, several approaches were employed to determine whether nascent mZP2 and mZP3 are cleaved at the consensus sites, -Arg-Ser-Lys-Arg- and -Arg-Asn-Arg-Arg-, respectively, prior to secretion.	Arginine	131-134	zona pellucida glycoprotein 3	Mus musculus	77-81
10493795-8	1999	However, for both mZP2 and mZP3, Arg residues were released by carboxypeptidase B, consistent with processing at the consensus furin cleavage site.	Arginine	33-36	zona pellucida glycoprotein 3	Mus musculus	27-31
10485881-2	1999	They are recognized by members of the serine/arginine-rich (SR) family of proteins, such as splicing factor 2/alternative splicing factor (SF2/ASF), which recruit basal splicing factors to form the initial complexes during spliceosome assembly.	Arginine	45-53	serine and arginine rich splicing factor 1	Homo sapiens	139-142
10485881-2	1999	They are recognized by members of the serine/arginine-rich (SR) family of proteins, such as splicing factor 2/alternative splicing factor (SF2/ASF), which recruit basal splicing factors to form the initial complexes during spliceosome assembly.	Arginine	45-53	serine and arginine rich splicing factor 1	Homo sapiens	143-146
10508422-2	1999	As compared to wild-type stromelysin-3, the kinetic parameters K(M) and k(cat) for the degradation of the fluorogenic substrate Dns-Pro-Leu-Ala-Leu-Trp-Ala-Arg-NH(2) (Dns-Leu) by these mutants indicated that the Gln/Leu substitution led to a 4-fold decrease in catalytic efficiency, whereas the mutations Gln/Tyr and Gln/Arg increased this parameter by a factor 10.	Arginine	156-159	matrix metallopeptidase 11	Homo sapiens	25-38
10487521-0	1999	Induction of apoptosis by the p53-273L (Arg --&gt; Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax.	Arginine	40-43	DnaJ heat shock protein family (Hsp40) member B7	Homo sapiens	66-70
10432298-9	1999	This contrasts markedly with the structure-function studies of C3a where both binding competency and function were dependent on the C-terminal Arg.	Arginine	143-146	complement C3	Homo sapiens	63-66
10458597-1	1999	The enzyme argininosuccinate synthetase (ASS) initiates the metabolic pathway leading from L-citrulline to L-arginine, the only physiological substrate of all isoforms of nitric oxide synthases.	Arginine	107-117	argininosuccinate synthase 1	Rattus norvegicus	11-39
10458597-1	1999	The enzyme argininosuccinate synthetase (ASS) initiates the metabolic pathway leading from L-citrulline to L-arginine, the only physiological substrate of all isoforms of nitric oxide synthases.	Arginine	107-117	argininosuccinate synthase 1	Rattus norvegicus	41-44
10409731-7	1999	ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth.	Arginine	69-77	Ssy1p	Saccharomyces cerevisiae S288C	0-4
10409731-7	1999	ssy1 and ptr3 mutants have increased vacuolar pools of histidine and arginine and exhibit altered cell growth morphologies accompanied by exaggerated invasive growth.	Arginine	69-77	Ptr3p	Saccharomyces cerevisiae S288C	9-13
10400673-4	1999	Identification of the two amino acids was achieved by dynamics-based docking of CCK in a refined three-dimensional model of CCK-AR using, as constraints, previous results that demonstrated that Trp-39/Gln-40 and Met-195/Arg-197 interact with the N terminus and the sulfated tyrosine of CCK, respectively.	Arginine	220-223	cholecystokinin A receptor	Homo sapiens	124-130
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Arginine	187-190	cholecystokinin A receptor	Homo sapiens	162-168
10400673-6	1999	This study also allowed us to demonstrate that (i) the identified interactions are crucial for stabilizing the high affinity phospholipase C-coupled state of the CCK-AR.CCK complex, (ii) Arg-336 and Asn-333 are directly involved in interactions with nonpeptide antagonists SR-27,897 and L-364,718, and (iii) Arg-336 but not Asn-333 is directly involved in the binding of the peptide antagonist JMV 179 and the peptide partial agonist JMV 180.	Arginine	308-311	cholecystokinin A receptor	Homo sapiens	162-168
10445381-0	1999	The effect of arginine-428 mutation on modulation of activity of human liver flavin monooxygenase 3 (FMO3) by imipramine and chlorpromazine.	Arginine	14-22	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	77-99
10445381-0	1999	The effect of arginine-428 mutation on modulation of activity of human liver flavin monooxygenase 3 (FMO3) by imipramine and chlorpromazine.	Arginine	14-22	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	101-105
10559906-5	1999	A negatively charged GIRK4 residue, two positions away from the most strongly interacting arginine, mediates stimulation of channel activity by sodium by strengthening channel-PtdIns(4,5)P2 interactions.	Arginine	90-98	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	21-26
10358075-3	1999	The same three sites, which all lie in the canonical PKB consensus sequences (Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr)), became phosphorylated when FKHR was cotransfected with either PKB or PDK1 (an upstream activator of PKB).	Arginine	78-81	pyruvate dehydrogenase kinase 1	Homo sapiens	179-183
10362683-2	1999	Although arginine transport in VSMC is considered to be mediated via the y+ system, we show here that rat VSMC in culture express the cat-1 gene transcript as well as an alternatively spliced transcript of the cat-2 gene.	Arginine	9-17	solute carrier family 7 member 2	Rattus norvegicus	210-215
10346979-7	1999	Moreover, the accumulation of arginine was higher in IL-1beta-treated beta cells than in control cells.beta cells expressed mRNAs for the two y+CAT transporters CAT-2A and CAT-2B with no change in transporter expression after exposure to IL-1beta.	Arginine	30-38	solute carrier family 7 member 2	Rattus norvegicus	161-167
10336483-3	1999	In this study, we identify a CaM-KK from Caenorhabditis elegans, and comparison of its sequence with the mammalian CaM-KK alpha and beta shows a unique Arg-Pro (RP)-rich insert in their catalytic domains relative to other protein kinases.	Arginine	152-155	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	115-127
10350608-4	1999	The N-terminal sequence obtained for this fragment, VEAIG, indicates that the formation of p45 and p40 arises from the cleavage of p70 between arginine-319 and valine-320.	Arginine	143-151	caspase 1	Rattus norvegicus	91-94
10360838-10	1999	HMP1 cleaved a prodynorphin-derived peptide, leumorphin, N-terminal to Arg in the monobasic processing site, as evidenced by MALDI-TOF mass spectrometry.	Arginine	71-74	pitrilysin metallopeptidase 1	Homo sapiens	0-4
10235127-2	1999	This study was designed to determine whether exogenous L-arginine modulates stress-induced gastric mucosal lesions through NO production by either constitutive NO synthase (cNOS) or inducible NO synthase (iNOS) in gastric mucosal tissues.	Arginine	55-65	nitric oxide synthase 3	Rattus norvegicus	173-177
10424349-3	1999	As in relaxin B-chain, an Arg-X-X-X-Arg sequence exists within the Ley I-L B-chain although it is located four residues towards the C-terminus from the corresponding position within relaxin.	Arginine	26-29	insulin-like 3	Rattus norvegicus	67-74
10424349-3	1999	As in relaxin B-chain, an Arg-X-X-X-Arg sequence exists within the Ley I-L B-chain although it is located four residues towards the C-terminus from the corresponding position within relaxin.	Arginine	36-39	insulin-like 3	Rattus norvegicus	67-74
10424349-9	1999	In order to explore further a possible structural relationship between Ley I-L and relaxin, we prepared a synthetic analogue of ovine Ley I-L containing a single replacement of B-chain residue 12, His, with Arg.	Arginine	207-210	insulin-like 3	Rattus norvegicus	134-141
10424349-10	1999	This was found to possess significant relaxin-like chronotropic and inotropic activity demonstrating that the tertiary structure of Ley I-L is similar to that of relaxin and highlighting the key requirement for the five-residue sequence, Arg-X-X-X-Arg, to be present in position B12-16 for characteristic relaxin activity.	Arginine	238-241	insulin-like 3	Rattus norvegicus	132-139
10424349-10	1999	This was found to possess significant relaxin-like chronotropic and inotropic activity demonstrating that the tertiary structure of Ley I-L is similar to that of relaxin and highlighting the key requirement for the five-residue sequence, Arg-X-X-X-Arg, to be present in position B12-16 for characteristic relaxin activity.	Arginine	248-251	insulin-like 3	Rattus norvegicus	132-139
10232408-5	1999	This mutation detection strategy disclosed a G-->A transition at nucleotide position 6,235 which resulted in substitution of a glycine by arginine within the collagenous region of COL7A1.	Arginine	138-146	collagen type VII alpha 1 chain	Homo sapiens	180-186
10102421-9	1999	Molecular genetic analysis revealed a new missense mutation located in codon 142 of the Cx32 gene leading to the substitution of an arginine by a glutamine.	Arginine	132-140	gap junction protein beta 1	Homo sapiens	88-92
10052934-6	1999	RBP binds at a 2-fold axis of symmetry in the TTR tetramer, and consequently the recognition site itself has 2-fold symmetry: Four TTR amino acids (Arg-21, Val-20, Leu-82, and Ile-84) are contributed by two monomers.	Arginine	148-151	retinol binding protein 4	Homo sapiens	0-3
10064736-0	1999	Identification of a novel Arg--&gt;Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs.	Arginine	26-29	low density lipoprotein receptor	Sus scrofa	55-67
10064737-10	1999	We conclude that amino acid residues arginine 160 and proline 165 of apoA-I contribute to the formation of a domain that is very important for initial lipid binding and contributes to LCAT-activation and promotion of initial cholesterol efflux but not to the stabilization of preformed rLpA-I.	Arginine	37-45	apolipoprotein A-I	Mus musculus	69-75
9950658-2	1999	Small-molecule antagonists of GP IIb/IIIa based on the Arg-Gly-Asp (RGD) sequence show similar benefit, and some of these agents are orally active.	Arginine	55-58	integrin subunit alpha 2b	Homo sapiens	30-36
9989851-9	1999	Genetic analysis using polymerase chain reaction with mutant enrichment and allele specific oligonucleotide hybridization detected a single mutation at codon 12 of K-ras, which changed the wild-type glycine to arginine.	Arginine	210-218	KRAS proto-oncogene, GTPase	Homo sapiens	164-169
10050223-4	1999	L-arginine analog N omega-nitro-L-arginine methyl ester (L-NAME) 10 mg.kg-1 to inhibit NO synthase (NOS).	Arginine	0-10	nitric oxide synthase 3	Canis lupus familiaris	87-98
10208646-7	1999	The codon 143 polymorphism appears to be linked to another new polymorphic alteration at codon 178, which converts lysine (AAG) to arginine (AGG).	Arginine	131-139	N-methylpurine DNA glycosylase	Homo sapiens	123-126
9915787-4	1999	The arginine 186-mediated negative regulation seems to be absent from Cdc42, a Rho family member important for cell-division cycle regulation, of lower eukaryotes, yet appears to be a part of the turn-off machinery of Cdc42 from higher eukaryotes.	Arginine	4-12	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	70-75
9915787-4	1999	The arginine 186-mediated negative regulation seems to be absent from Cdc42, a Rho family member important for cell-division cycle regulation, of lower eukaryotes, yet appears to be a part of the turn-off machinery of Cdc42 from higher eukaryotes.	Arginine	4-12	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	218-223
9915787-5	1999	Introduction of the arginine 186 mutation into S. cerevisiae CDC42 led to phenotypes consistent with down-regulated CDC42 function.	Arginine	20-28	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	61-66
9915787-5	1999	Introduction of the arginine 186 mutation into S. cerevisiae CDC42 led to phenotypes consistent with down-regulated CDC42 function.	Arginine	20-28	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	116-121
9893994-10	1999	In the presence of aluminum fluoride, the R282A mutant RhoGAP binds almost as well as the wild type to Rho.GDP, demonstrating that the conserved arginine is not required for this interaction.	Arginine	145-153	Rho GTPase activating protein 1	Homo sapiens	55-61
10440846-8	1999	We propose that oviductin possessing the substrate specificity of GSR simultaneously digests gp43 at Arg residues in GSR61 and GSR373 to generate the N- and C-terminus of gp41, respectively.	Arginine	101-104	ovochymase 2 S homeolog	Xenopus laevis	16-25
9914499-3	1999	Arg-DHFRts, an engineered N-end rule substrate, bears N-terminal arginine (a destabilizing residue) and DHFRts [a temperature-sensitive mouse dihydrofolate reductase (DHFR) moiety].	Arginine	65-73	dihydrofolate reductase	Mus musculus	4-8
10319589-4	1999	Secondly, we found a point mutation, T2763G, resulting in a leucine-to-arginine conversion, which we predicted would cause a change in the secondary structure of the Menkes protein.	Arginine	71-79	ATPase copper transporting alpha	Homo sapiens	166-172
9989468-5	1999	Both 7-nitroindazole and aminoguanidine significantly antagonized the increases of cNOS and iNOS activities measured by conversion of 3H-L-arginine to 3H-L-citrulline in the ventral spinal cord, and blocked the Dyn-induced increases of ncNOS-immunoreactivity in the ventral horn cells 4 h after i.t.	Arginine	134-147	nitric oxide synthase 3	Rattus norvegicus	83-87
10622266-9	1999	Ten millimolar 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of GTPCH, strongly reduced L-Arg-induced relaxation, and decreased BH4 content to below the basal level in LPS-treated aorta, whereas 0.5 mM DAHP reduced the LPS-induced increase in BH4 content to the basal level but did not affect L-Arg-induced relaxation.	Arginine	95-100	GTP cyclohydrolase 1	Rattus norvegicus	71-76
10622266-9	1999	Ten millimolar 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of GTPCH, strongly reduced L-Arg-induced relaxation, and decreased BH4 content to below the basal level in LPS-treated aorta, whereas 0.5 mM DAHP reduced the LPS-induced increase in BH4 content to the basal level but did not affect L-Arg-induced relaxation.	Arginine	300-305	GTP cyclohydrolase 1	Rattus norvegicus	71-76
9837948-5	1998	In peptides interacting with the human protein, hydrophobic residues were found with high frequency especially at positions -2 and -5, whereas peptides interacting with S. cerevisiae Pex5p were more hydrophilic and frequently contained arginine at position -2.	Arginine	236-244	Pex5p	Saccharomyces cerevisiae S288C	183-188
9868533-4	1998	Especially, CCK-OP-stimulated increase of arginine to citrulline transformation, the amount of NOx and cGMP level were completely counteracted by the inhibitor of NOS, NG-monomethyl-L-arginine (MMA), by contrast, that of amylase release was partially reduced.	Arginine	42-50	cholecystokinin	Rattus norvegicus	12-15
9788833-0	1998	Enhanced monocyte tissue factor response after experimental balloon angioplasty in hypercholesterolemic rabbit: inhibition with dietary L-arginine.	Arginine	136-146	tissue factor	Oryctolagus cuniculus	18-31
9788833-3	1998	We investigated whether L-arginine (L-arg), the endogenous precursor of NO, might affect the ability of monocytes to produce TF.	Arginine	24-34	tissue factor	Oryctolagus cuniculus	125-127
9788833-3	1998	We investigated whether L-arginine (L-arg), the endogenous precursor of NO, might affect the ability of monocytes to produce TF.	Arginine	24-29	tissue factor	Oryctolagus cuniculus	125-127
9788833-10	1998	This increase was blunted by L-arg (43+/-16 mU of TF/1000 monocytes, P=0.01).	Arginine	29-34	tissue factor	Oryctolagus cuniculus	50-52
9788833-11	1998	CONCLUSIONS: This study demonstrates that angioplasty-induced plaque rupture is associated with a marked increase in monocyte TF response that is blunted by the oral administration of L-arg.	Arginine	184-189	tissue factor	Oryctolagus cuniculus	126-128
9809802-3	1998	Recombinant R44S-PSTI was obtained using by site-directed mutagenesis due to replacement of arginine by serine that led to longer half life of this peptide than its natural form.	Arginine	92-100	serine peptidase inhibitor, Kazal type 1-like	Rattus norvegicus	16-21
9826199-1	1998	The importance in catalysis of the conserved arginine (R207) and lysine residues (K144, K294, K356, and K425) of 6-phosphoglucose isomerase from Bacillus stearothermophilus was assessed by site-directed mutagenesis and kinetic analysis.	Arginine	45-53	glucose-6-phosphate isomerase	Sus scrofa	115-139
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Arginine	219-222	coagulation factor II, thrombin	Bos taurus	32-40
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Arginine	219-222	spleen trypsin inhibitor I	Bos taurus	47-51
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Arginine	219-222	spleen trypsin inhibitor I	Bos taurus	87-91
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Arginine	219-222	coagulation factor II, thrombin	Bos taurus	185-193
9748320-3	1998	In the crystal structure of the thrombin E192Q-BPTI complex, the reactive site loop of BPTI is stabilized in a canonical conformation by several productive interactions (e.g., Glu39 of thrombin is ion-paired to the P5" Arg, and Gln192 is hydrogen-bonded to the P2 and P4 backbone carbonyls of BPTI).	Arginine	219-222	spleen trypsin inhibitor I	Bos taurus	87-91
9724550-9	1998	These results indicate that Arg-42 and Thr-45 form critical noncovalent interactions with FAD that are required for the subsequent activation of MAO B by covalent coupling of FAD.	Arginine	28-31	monoamine oxidase B	Homo sapiens	145-150
9796820-5	1998	Molecular modelling studies indicate that this complex could be stabilized by electrostatic interactions involving the glutamate Glu287 and aspartates (Asp290, Asp294, Asp297 and Asp298) of L(281-301)TFIIA and lysine residues (Lys133, Lys138 and Lys145) and arginine residues (Arg137, Arg140) of H2(TBP) in agreement with mutagenesis experiments.	Arginine	258-266	TATA-box binding protein	Homo sapiens	299-302
9712892-8	1998	High concentrations of L-arginine decreased this O-2 formation, whereas its enantiomer D-arginine did not.	Arginine	23-33	immunoglobulin kappa variable 1D-39	Homo sapiens	49-52
9710445-6	1998	The NO synthase inhibitor Nomega-nitro- L-arginine (L-NNA) also blocked the response to GLP-1, whereas L-arginine restored the response.	Arginine	40-50	glucagon	Rattus norvegicus	88-93
9685421-0	1998	A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/SF2 binding.	Arginine	9-17	serine and arginine rich splicing factor 1	Homo sapiens	90-97
9685421-3	1998	ASF/SF2, SC35, and other members of the serine/arginine family, interact with the 70k protein of the U1 small nuclear ribonucleoprotein.	Arginine	47-55	serine and arginine rich splicing factor 1	Homo sapiens	0-7
9685421-5	1998	It has been clearly documented that the arginine/serine domain of ASF/SF2 is responsible for binding to the U1 70k protein.	Arginine	40-48	serine and arginine rich splicing factor 1	Homo sapiens	66-73
9685421-7	1998	A domain within this segment, which begins with Arg240 and ends with Asp270, was shown to bind specifically to the arginine/serine domain of ASF/SF2 using a yeast two-hybrid system and a far Western assay.	Arginine	115-123	serine and arginine rich splicing factor 1	Homo sapiens	141-148
9685421-8	1998	Mutational analysis of this segment suggested that several arginines are critical for the interaction with ASF/SF2 and for phosphorylation by SRPK1.	Arginine	59-68	serine and arginine rich splicing factor 1	Homo sapiens	107-114
9753390-2	1998	The importance of the residues located near the Arg-Lys dibasic site in the C-terminal region of the pro-hormone for the cleavage of the precursor into somatostatin-14 has been confirmed.	Arginine	48-51	somatostatin	Homo sapiens	152-167
9730240-3	1998	Structure-activity relationship (SAR) studies on T22 have disclosed the contributions of each region of T22 to activity or cytotoxicity, and have provided the following useful information to develop new CXCR4 antagonists: The number of Arg residues in the N-terminal and C-terminal regions of T22 is closely related to anti-HIV activity.	Arginine	236-239	C-X-C motif chemokine receptor 4	Homo sapiens	203-208
9632111-7	1998	Taken together, these data reveal that the region of hVDR between Arg-49 and Lys-55 contains a novel constitutive nuclear localization signal, RRSMKRK.	Arginine	66-69	vitamin D receptor	Homo sapiens	53-57
9710746-5	1998	For all subjects, circulating neutrophil counts increased 33% (P &lt; 0.0001) and lactoferrin increased 27% (P = 0.0006) after exercise, whereas plasma C3a des arg and creatine kinase did not increase.	Arginine	160-163	complement C3	Homo sapiens	152-155
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	23-26	coagulation factor X	Homo sapiens	146-155
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	32-35	coagulation factor X	Homo sapiens	146-155
9632668-3	1998	Thrombin cleaves FV at Arg-709, Arg-1018, and Arg-1545 that leads to the generation of a procoagulant FV species which functions as a cofactor to factor Xa (FXa) in the activation of prothrombin to thrombin.	Arginine	32-35	coagulation factor X	Homo sapiens	146-155
9576868-4	1998	Apparent Kd values for nNOS haem-domain-binding of arginine and Nomega-nitro-L-arginine (nitroarginine) were measured as 1.6 microM and 25 nM respectively.	Arginine	51-59	nitric oxide synthase 1	Rattus norvegicus	23-27
9576868-6	1998	These values are comparable to literature values obtained for full-length nNOS, suggesting that many characteristics of the arginine binding site of NOS are conserved in the haem-binding domain.	Arginine	124-132	nitric oxide synthase 1	Rattus norvegicus	74-78
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	213-216
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	218-223
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	225-229
9602069-9	1998	Our results suggest that L-ARG plays an important role in inhibiting KA-induced proENK or proDYN mRNA expression, and its inhibitory action may be mediated through reducing the proto-oncoprotein levels, such as c-Fos, Fra-2, FosB, c-Jun, JunD, and JunB.	Arginine	25-30	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	238-242
9635276-7	1998	In addition, these isoforms all contain the four residue PP1c-binding motif (Arg/Lys-Val/Ile-Xaa-Phe).	Arginine	77-80	protein phosphatase 1 catalytic subunit gamma	Homo sapiens	57-61
9657332-8	1998	Some of these are shared with human cathepsin B, including Glu 205 (papain numbering), known to permit cleavage of Arg-Arg peptide bonds.	Arginine	115-118	cathepsin B	Homo sapiens	36-47
9657332-8	1998	Some of these are shared with human cathepsin B, including Glu 205 (papain numbering), known to permit cleavage of Arg-Arg peptide bonds.	Arginine	119-122	cathepsin B	Homo sapiens	36-47
9578487-1	1998	Carbamate kinase (CK) catalyzes the reversible reaction NH2COO- + ATP &lt;--&gt; NHCOOPO3(2-) + ADP, serving to synthesize ATP from carbamoyl phosphate in those microorganisms that derive energy from anaerobic arginine degradation via the arginine dihydrolase pathway.	Arginine	210-218	carbamate kinase	Escherichia coli	0-16
9578487-1	1998	Carbamate kinase (CK) catalyzes the reversible reaction NH2COO- + ATP &lt;--&gt; NHCOOPO3(2-) + ADP, serving to synthesize ATP from carbamoyl phosphate in those microorganisms that derive energy from anaerobic arginine degradation via the arginine dihydrolase pathway.	Arginine	210-218	carbamate kinase	Escherichia coli	18-20
9588954-4	1998	On the other hand, the Lys-Arg bond (position 3-4) was found to be susceptible only to gamma-NGF.	Arginine	27-30	kallikrein 1-related peptidase b3	Mus musculus	87-96
9521691-5	1998	Acetoacetylation of 74% of lysine residues and cyclohexanedione modification of 54% of arginine residues completely abolished the interactions between LDL and MTP.	Arginine	87-95	microsomal triglyceride transfer protein	Homo sapiens	159-162
9521691-6	1998	Regeneration of lysine and arginine residues by hydroxylamine treatment completely restored the binding of modified LDL to MTP.	Arginine	27-35	microsomal triglyceride transfer protein	Homo sapiens	123-126
9521691-10	1998	These studies indicated that lysine and arginine, but not aspartic and glutamic acid, residues are critical for apoB-MTP interactions, whereas histidine residues are not as critical.	Arginine	40-48	microsomal triglyceride transfer protein	Homo sapiens	117-120
9510178-6	1998	Each cluster, transferred by site-directed mutagenesis from the permissive to the restrictive sequence, can independently confer on TAP a partial ability to transport peptides with arginine at the C terminus.	Arginine	181-189	SEC14-like lipid binding 2	Rattus norvegicus	132-135
9488672-3	1998	Unlike other proteins that interact with heparin via lysine or arginine residues, HPRG relies exclusively on histidine residues for this interaction.	Arginine	63-71	histidine rich glycoprotein	Homo sapiens	82-86
9485424-4	1998	In the SH2 domains of SHP-2, the highly conserved alphaA2 Arg is replaced by Gly.	Arginine	58-61	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	22-27
9615731-5	1998	Another was located on codon 174 and replaced AGG (Arg) with AAG (Lys).	Arginine	51-54	N-methylpurine DNA glycosylase	Homo sapiens	61-64
9568289-1	1998	A novel hexapeptide, H-Pro-Ser-Nva-Gly-Asp-Trp-OH 6, a specific antagonist of platelet fibrinogen receptor (GpIIb/IIIa), was discovered in a structure-activity relationship (SAR) study where the role of the N-terminal Pro moiety of an RGD-containing peptide, H-Pro-Ser-Arg-Gly-Asp-Trp-OH 1, which is a potent but not specific antagonist toward GpIIb/IIIa integrin, was investigated.	Arginine	269-272	integrin subunit alpha 2b	Homo sapiens	108-113
9527396-0	1998	L-arginine suppresses lipopolysaccharide-induced expression of RANTES in glomeruli.	Arginine	0-10	C-C motif chemokine ligand 5	Rattus norvegicus	63-69
10099200-6	1998	To examine whether l-arginine affects the activities of intracellular proteases such as KEX2 endoproteinase or extracellular proteases, the proteolysis experiments were performed by incubating the commercial intact hPTH in a yeast host culture supernatant.	Arginine	19-29	kexin KEX2	Saccharomyces cerevisiae S288C	88-92
9537673-8	1998	These results suggest that the binding mechanism of 125I-[Sar1-Ile8]Ang II to AT2 receptor is similar to that of AT1 receptor since an amino acid with positively charged side chain (Lys or Arg) located in the fifth transmembrane domain is required for this ligand to bind AT2 receptor.	Arginine	189-192	angiotensin II receptor type 2 L homeolog	Xenopus laevis	78-81
9537673-8	1998	These results suggest that the binding mechanism of 125I-[Sar1-Ile8]Ang II to AT2 receptor is similar to that of AT1 receptor since an amino acid with positively charged side chain (Lys or Arg) located in the fifth transmembrane domain is required for this ligand to bind AT2 receptor.	Arginine	189-192	angiotensin II receptor type 2 L homeolog	Xenopus laevis	272-275
10806843-0	1998	Effect of aluminum on long-term potentiation and its relation to L-arg-NO-pathway in hippocampal CA3 area of rats.	Arginine	65-70	carbonic anhydrase 3	Rattus norvegicus	97-100
10806843-7	1998	Preinjection of L-arginine (0.3 mol/L, 1 microliter) into CA3 could antagonize the inhibitory effect of Al on LTP.	Arginine	16-26	carbonic anhydrase 3	Rattus norvegicus	58-61
9428387-0	1998	Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors.	Arginine	39-47	RBPJ pseudogene 3	Homo sapiens	28-31
9428387-7	1998	RESULTS: hK2 was found to cleave peptide substrates exclusively at selected arginine residues.	Arginine	76-84	RBPJ pseudogene 3	Homo sapiens	9-12
9428387-11	1998	CONCLUSIONS: These results demonstrate that hK2 is an active protease with arginine-selective specificity, which forms covalent complexes with plasma protease inhibitors.	Arginine	75-83	RBPJ pseudogene 3	Homo sapiens	44-47
9395443-2	1997	When incubated with solubilized PAEC plasma membrane proteins, eNOS-specific antibody immunoprecipitates CAT1-mediated arginine transport.	Arginine	119-127	solute carrier family 7 member 1	Homo sapiens	105-109
9395443-3	1997	These results document the existence of a caveolar complex between CAT1 and eNOS in PAEC that provides a mechanism for the directed delivery of substrate arginine to eNOS.	Arginine	154-162	solute carrier family 7 member 1	Homo sapiens	67-71
9343420-6	1997	The replacement of three arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding and inhibition of MyoD by M-Twist, while the domain retained other M-Twist functions such as heterodimerization with an E protein and inhibition of MEF2 transactivation.	Arginine	25-33	twist basic helix-loop-helix transcription factor 1	Mus musculus	62-69
9343420-6	1997	The replacement of three arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding and inhibition of MyoD by M-Twist, while the domain retained other M-Twist functions such as heterodimerization with an E protein and inhibition of MEF2 transactivation.	Arginine	25-33	twist basic helix-loop-helix transcription factor 1	Mus musculus	152-159
9343420-6	1997	The replacement of three arginine residues by alanines in the M-Twist basic domain was sufficient to abolish both the binding and inhibition of MyoD by M-Twist, while the domain retained other M-Twist functions such as heterodimerization with an E protein and inhibition of MEF2 transactivation.	Arginine	25-33	twist basic helix-loop-helix transcription factor 1	Mus musculus	152-159
9549298-13	1997	The CD4/CD8 ratio raised from 1.05 +/- 0.29 to 1.51 +/- 0.46 (p &lt; 0.01) in the L-arginine group, from 1.12 +/- 0.16 to 1.27 +/- 0.24 in the placebo group.	Arginine	82-92	CD8a molecule	Homo sapiens	8-11
9341143-7	1997	Deletion analyses of recombinant derivatives of eIF3-p66 show that the RNA-binding domain lies within an N-terminal 71-amino acid region rich in lysine and arginine.	Arginine	156-164	eukaryotic translation initiation factor 3 subunit D	Homo sapiens	48-56
9361375-3	1997	This leads to a NO synthesis from L-Arginine (L-Arg), which in turn increases cyclic GMP and down-regulates platelet aggregation (2).	Arginine	34-44	5'-nucleotidase, cytosolic II	Homo sapiens	85-88
9361375-3	1997	This leads to a NO synthesis from L-Arginine (L-Arg), which in turn increases cyclic GMP and down-regulates platelet aggregation (2).	Arginine	34-39	5'-nucleotidase, cytosolic II	Homo sapiens	85-88
9361375-4	1997	In vitro administration of supraphysiological concentrations of L-Arg enhances platelet cyclic GMP levels by increasing NO production and reduces platelet aggregation.	Arginine	64-69	5'-nucleotidase, cytosolic II	Homo sapiens	95-98
9317167-3	1997	Both cleavage sites are immediately after an arginine residue at position 653 for IA-2 and position 679 for IA-2 beta.	Arginine	45-53	protein tyrosine phosphatase receptor type N	Homo sapiens	82-86
9348541-0	1997	The rat myosin myr 5 is a GTPase-activating protein for Rho in vivo: essential role of arginine 1695.	Arginine	87-95	myosin IXB	Homo sapiens	15-20
9348541-7	1997	Mutation of the corresponding arginine residue in the myr 5 GAP domain to a methionine (M1695) virtually abolished Rho-GAP activity.	Arginine	30-38	myosin IXB	Homo sapiens	54-59
9348541-7	1997	Mutation of the corresponding arginine residue in the myr 5 GAP domain to a methionine (M1695) virtually abolished Rho-GAP activity.	Arginine	30-38	Rho GTPase activating protein 1	Homo sapiens	115-122
9307032-0	1997	Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.	Arginine	167-170	coagulation factor II, thrombin	Bos taurus	74-82
9307032-1	1997	A peptide containing residues 1-50 of the Aalpha-chain of fibrinogen, expressed as a fusion peptide with beta-galactosidase, is rapidly cleaved by thrombin at Arg-16, similarly to whole fibrinogen.	Arginine	159-162	coagulation factor II, thrombin	Bos taurus	147-155
9275097-3	1997	In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue.	Arginine	53-56	cholecystokinin	Mus musculus	45-48
9275097-3	1997	In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue.	Arginine	53-56	carboxypeptidase E	Mus musculus	62-65
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	20-23
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	39-42
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	48-51
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9286980-0	1997	Cloning and characterization of argR, a gene that participates in regulation of arginine biosynthesis and catabolism in Pseudomonas aeruginosa PAO1.	Arginine	80-88	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	32-36
9286980-5	1997	Determination of the nucleotide sequence of the flanking regions showed that argR is the sixth and terminal gene of an operon for transport of arginine.	Arginine	143-151	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	77-81
9286980-7	1997	Inactivation of argR abolished arginine control of the biosynthetic enzymes encoded by the car and argF operons.	Arginine	31-39	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	16-20
9286980-8	1997	Furthermore, argR inactivation abolished the induction of several enzymes of the arginine succinyltransferase pathway, which is considered the major route for arginine catabolism under aerobic conditions.	Arginine	81-89	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	13-17
9286980-9	1997	Consistent with this finding and unlike the parent strain, the argR::Gm derivative was unable to utilize arginine or ornithine as the sole carbon source.	Arginine	105-113	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	63-67
9286980-10	1997	The combined data indicate a major role for ArgR in the control of arginine biosynthesis and aerobic catabolism.	Arginine	67-75	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	44-48
9301433-4	1997	The L-arginine-nitric oxide (NO)-cyclic GMP (cGMP) pathway plays an important role in counteracting vasospasm.	Arginine	4-14	5'-nucleotidase, cytosolic II	Homo sapiens	40-43
9211873-6	1997	Its formation was first order with respect to O2, monophasic, and gave rate constants for kon = 9 x 10(5) M-1 s-1 and koff = 108 s-1 for an L-arginine- and tetrahydrobiopterin (H4B)-saturated nNOSoxy.	Arginine	140-150	H4 clustered histone 4	Homo sapiens	177-180
9248702-7	1997	Addition of Arg residues at B31-32, on the backbone of either HI or AspB10 HI, increased affinity for the IGF-I receptor 10 and 28 fold, respectively, compared to HI, confirming the significance of enhanced positive charge at the C-terminal end of the insulin B-chain in increasing selectivity for the IGF-I receptor.	Arginine	12-15	insulin like growth factor 1 receptor	Homo sapiens	106-120
9182828-3	1997	The study revealed a G-to-A transition at nucleotide 6724 within exon 85 of COL7A1, converting a glycine to an arginine (G2242R) within the triple-helical domain of the type VII collagen in affected individuals.	Arginine	111-119	collagen type VII alpha 1 chain	Homo sapiens	76-82
9153260-8	1997	Thrombin specifically cleaved chicken OPN at two sites: between Arg-22 and Ser-23, which generated the 5-kDa N-terminal end fragment, and another between Lys-138 and Ala-139, which generated the 30- and 20-kDa fragments.	Arginine	64-67	coagulation factor II, thrombin	Gallus gallus	0-8
9176369-1	1997	Arginine decarboxylase is present in the kidney and metabolizes the amino acid, arginine, to agmatine.	Arginine	80-88	antizyme inhibitor 2	Rattus norvegicus	0-22
9242985-0	1997	Evidence for a specific interaction of vitronectin with arginine: effects of reducing agents on the expression of functional domains and immunoepitopes.	Arginine	56-64	vitronectin	Homo sapiens	39-50
9242985-2	1997	Here, we report that denatured Vn specifically binds to L-Arg, whereas the L-Arg binding site is cryptic in the native form of Vn.	Arginine	56-61	vitronectin	Homo sapiens	31-33
9242985-2	1997	Here, we report that denatured Vn specifically binds to L-Arg, whereas the L-Arg binding site is cryptic in the native form of Vn.	Arginine	75-80	vitronectin	Homo sapiens	127-129
9242985-3	1997	In addition, combined treatment of disulfide-linked Vn multimers with L-Arg, urea, and reducing agent results in the formation of disperse oligomers with reduced expression of denaturation-sensitive epitopes.	Arginine	70-75	vitronectin	Homo sapiens	52-54
9242985-4	1997	These results suggest that L-Arg modulates the partitioning between monomeric and multimeric Vn species and that L-Arg affinity chromatography can be employed to test for exposure of conformationally sensitive binding sites in Vn.	Arginine	27-32	vitronectin	Homo sapiens	93-95
9242985-4	1997	These results suggest that L-Arg modulates the partitioning between monomeric and multimeric Vn species and that L-Arg affinity chromatography can be employed to test for exposure of conformationally sensitive binding sites in Vn.	Arginine	113-118	vitronectin	Homo sapiens	227-229
9134226-19	1997	Pretreatment with L-NMMA caused a prompt drop in myeloperoxidase (MPO), activity, suggesting rapid adhesion of PMNL to the coronary wall; this effect was significantly blunted by L-arginine.	Arginine	179-189	myeloperoxidase	Oryctolagus cuniculus	49-64
9134226-19	1997	Pretreatment with L-NMMA caused a prompt drop in myeloperoxidase (MPO), activity, suggesting rapid adhesion of PMNL to the coronary wall; this effect was significantly blunted by L-arginine.	Arginine	179-189	myeloperoxidase	Oryctolagus cuniculus	66-69
9060883-8	1997	After oral L-arginine, monocyte/ endothelial cell adhesion was reduced in smokers (from 46.4 +/- 4.5% to 35.1 +/- 4.0%, p = 0.002), as was endothelial cell expression of ICAM-1 (from 0.31 +/- 0.02 to 0.27 +/- 0.01, p = 0.001).	Arginine	11-21	intercellular adhesion molecule 1	Homo sapiens	170-176
9041554-9	1997	These results suggest that L-[3H]NNA seems to bind the substrate-binding domain in the nNOS but the binding affinity of L-Arg was lower than the affinity of L-NNA.	Arginine	120-125	nitric oxide synthase 1	Rattus norvegicus	87-91
9044371-10	1997	In addition, the selective cholecystokinin-A receptor antagonist, L-364,718 (10 microM), but not the selective cholecystokinin-B receptor antagonist, L-365,260 (100 microM), blocked the effect of cholecystokinin on synaptic transmission.	Arginine	66-68	cholecystokinin	Rattus norvegicus	27-42
9048578-9	1997	Kex2 was demonstrated to be exquisitely selective for Arg at P1.	Arginine	54-57	kexin KEX2	Saccharomyces cerevisiae S288C	0-4
9043106-1	1997	The ARG5,6 gene from the dimorphic fungus Candida albicans was cloned by functional complementation of the arginine auxotrophy present in strain EL2 (Arg-) using a gene library constructed in the double autonomously replicating sequence vector pRM1.	Arginine	107-115	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	4-10
9043106-1	1997	The ARG5,6 gene from the dimorphic fungus Candida albicans was cloned by functional complementation of the arginine auxotrophy present in strain EL2 (Arg-) using a gene library constructed in the double autonomously replicating sequence vector pRM1.	Arginine	150-153	bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Saccharomyces cerevisiae S288C	4-10
9203626-1	1997	We characterized a new iodinated, high affinity, linear V1a vasopressin antagonist, phenylacetylD-Tyr(Et)Phe-Gln-Asn-Lys-Pro-Arg-Tyr-NH2.	Arginine	125-128	arginine vasopressin receptor 1A	Rattus norvegicus	56-59
9038979-7	1997	nNOS activity, assessed by the conversion of labeled arginine to citrulline, was inhibited by 70 +/- 7% after the administration of 7-NI.	Arginine	53-61	nitric oxide synthase 1	Rattus norvegicus	0-4
9039115-5	1997	The increase in plasma cyclic GMP in response to L-arginine was lower in hypertensive patients than in normotensive subjects.	Arginine	49-59	5'-nucleotidase, cytosolic II	Homo sapiens	30-33
9039115-7	1997	In all subjects, the peak cyclic GMP response to L-arginine was significantly correlated with the peak delta glucose/ delta insulin ratio response to L-arginine (r = .69, P &lt; .001).	Arginine	49-59	5'-nucleotidase, cytosolic II	Homo sapiens	33-36
9039115-7	1997	In all subjects, the peak cyclic GMP response to L-arginine was significantly correlated with the peak delta glucose/ delta insulin ratio response to L-arginine (r = .69, P &lt; .001).	Arginine	150-160	5'-nucleotidase, cytosolic II	Homo sapiens	33-36
9039115-9	1997	A link may be present between the abnormality of the L-arginine/nitric oxide/cyclic GMP pathway and insulin resistance in patients with essential hypertension.	Arginine	53-63	5'-nucleotidase, cytosolic II	Homo sapiens	84-87
9020386-5	1997	Recently a mutational thymidine (T)--&gt;guanosine (G) transversion in isoform 1 of the PMCA has been identified resulting in the substitution of a methionine (Met) by an arginine (Arg) at amino acid position 267 in a highly conserved domain of the pump molecule.	Arginine	171-179	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	88-92
9120775-9	1997	These studies suggest that the glycoprotein IIb/IIIa complex, present on activated-platelets, may interact with fibronectin and vitronectin substrates through the Arg-Gly-Asp-dependent mechanism.	Arginine	163-166	vitronectin	Homo sapiens	128-139
9016354-6	1997	The substitution of Arg2 or Arg4 in FRCRCFa with lysine or ornithine decreases the inhibitory potency by 5-12-fold, suggesting that both arginines are beneficial for inhibition.	Arginine	137-146	arginase 2	Homo sapiens	20-24
8977249-4	1996	From patient ITP-1 (known to have two distinct autoantibodies), we identified anti-GPIIb/IIIa antibody-specific phage encoding the peptide sequences Arg-Glu-Lys-Ala-Lys-Trp (REKAKW) and Pro-Val-Val-Trp-Lys-Asn (PVVWKN).	Arginine	149-152	integrin subunit alpha 2b	Homo sapiens	83-88
8982281-1	1996	Rabbit secretin, which differs from all other mammalian secretins in having a Leu residue in position 6 (instead of Phe) and a basic residue (Arg) in position 16, had a lower affinity than porcine secretion on recombinant rat secretin receptors but had a greater affinity than porcine secretin on recombinant rat VIP1 and PACAP I receptors.	Arginine	142-145	secretin	Homo sapiens	7-15
8982281-3	1996	Thus, an arginine residue in position 16 reduced 3-fold the affinity of secretin for secretin receptors but increased 30-fold its affinity for the VIP1 and PACAP I receptors.	Arginine	9-17	secretin	Homo sapiens	72-80
8982281-3	1996	Thus, an arginine residue in position 16 reduced 3-fold the affinity of secretin for secretin receptors but increased 30-fold its affinity for the VIP1 and PACAP I receptors.	Arginine	9-17	secretin	Homo sapiens	85-93
8982281-4	1996	The introduction of an arginine residue in position 16, instead of glutamine, in VIP and PACAP had a similar effect: [R16] VIP and [R16] PACAP had 3- to 10-fold higher affinities than VIP and PACAP for VIP1 and PACAP I receptors, and 3-fold lower affinities for the secretin receptors.	Arginine	23-31	secretin	Rattus norvegicus	266-274
8942987-2	1996	Using a monoclonal antibody, 1E4, we have shown that the yeast NPL3 gene product Np13p, an essential RNA binding protein with repeated RGG motifs, is arginine-methylated in vivo.	Arginine	150-158	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	63-67
8916913-3	1996	To probe the role of the C-terminal loops in determining substrate specificities in these enzymes, two arginine residues, Arg308 and Arg311, located in the C-terminal loop of aldehyde reductase, and not found in any other C-terminal loop, were replaced with alanine residues.	Arginine	103-111	aldo-keto reductase family 1 member A1	Homo sapiens	175-193
9007276-10	1996	This difference is discussed on basis of modeling, taking in view the difference at position 13, with Arg in pLT and His in hLT.	Arginine	102-105	Leucine transport, high	Homo sapiens	124-127
8918456-4	1996	The optimal sequence for interaction with mu 2 and with AP-2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3.	Arginine	99-107	transcription factor AP-2 alpha	Homo sapiens	56-60
8900157-4	1996	Point mutagenesis within AF-1a revealed that two adjacent hydrophobic residues were required for full AR trans-activation function, as arginine substitutions resulted in a 60% reduction in transcriptional activity.	Arginine	135-143	androgen receptor	Rattus norvegicus	102-104
9064323-7	1996	Comparative protein modeling and electrostatic calculations disclosed that mMCP-6 contains a prominent Lys/Arg-rich domain on its surface, distant from the active site.	Arginine	107-110	tryptase beta 2	Mus musculus	75-81
8819532-4	1996	In contrast, extended survival was observed for animals expressing an arginine-22 variant (Arg22) DHFR transgene, with the last three of eight animals in this group succumbing at a final MTX dose of 14 mg/kg i.p.	Arginine	70-78	dihydrofolate reductase	Mus musculus	98-102
8799112-3	1996	In this paper we show that all of the phosphorylated, mAb 104 detectable, Ser/Arg-rich essential splicing factors (SR proteins) in the nucleoplasm are integral components of the InRNP particles, whereas only part of the essential splicing factor U2AF65 (U2 snRNP auxiliary factor) and the polypyrimidine tract binding protein (PTB) are associated with these particles.	Arginine	78-81	polypyrimidine tract binding protein 1	Homo sapiens	289-325
8799112-3	1996	In this paper we show that all of the phosphorylated, mAb 104 detectable, Ser/Arg-rich essential splicing factors (SR proteins) in the nucleoplasm are integral components of the InRNP particles, whereas only part of the essential splicing factor U2AF65 (U2 snRNP auxiliary factor) and the polypyrimidine tract binding protein (PTB) are associated with these particles.	Arginine	78-81	polypyrimidine tract binding protein 1	Homo sapiens	327-330
8869791-9	1996	C3a des Arg and the C5b-C9 fraction were detected by commercially available immunoassays.	Arginine	8-11	complement C3	Homo sapiens	0-3
8812829-0	1996	Overexpression, purification, and refolding of link module from human TSG-6 in Escherichia coli: effect of temperature, media, and mutagenesis on lysine misincorporation at arginine AGA codons.	Arginine	173-181	TNF alpha induced protein 6	Homo sapiens	70-75
8663387-4	1996	beta3 is a polymorphic variant at ADH2 that differs from beta1 by a single amino acid substitution of Arg-369 --&gt; Cys.	Arginine	102-105	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	57-62
8800516-4	1996	Acute exposure to arginine (10 mM) and theophylline (10 mM), but not glucose (20 mM), calcium chloride (10 mM), and sodium butyrate (10 mM), caused acute secretion of insulin.	Arginine	18-26	LOC105613195	Ovis aries	167-174
8675186-7	1996	In Kupffer cells, the presence of an arginine analog, NG-methyl-L-arginine, attenuated nitrite formation induced by PAF and LPS alone or in combination.	Arginine	37-45	PCNA clamp associated factor	Rattus norvegicus	116-119
8814458-5	1996	More than 95% of Z-Arg-Arg-MCA hydrolytic activity in each GCF sample was inhibited by CA-074, specific inhibitor of cathepsin B.	Arginine	19-22	cathepsin B	Homo sapiens	117-128
8811415-5	1996	Cerebral arterial dilatation caused by nerve stimulation is abolished by NO synthase inhibition and is restored by L-arginine, a substrate of NO synthase; vasodilator nerve stimulation increases the production of cyclic GMP in the tissue and liberates NOx (nitroxy compounds) from the arterial strip into superfusate.	Arginine	115-125	5'-nucleotidase, cytosolic II	Homo sapiens	220-223
8662674-1	1996	Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B.	Arginine	14-24	solute carrier family 7 member 2	Rattus norvegicus	63-69
8662674-1	1996	Regulation of L-arginine transport and no production by CAT-1, CAT-2A, and CAT-2B.	Arginine	14-24	solute carrier family 7 member 2	Rattus norvegicus	75-81
8626679-8	1996	Northern analysis revealed that the cytokine-stimulated increase in L-arginine transport coincided with increased levels of cat-2 mRNA.	Arginine	68-78	solute carrier family 7 member 2	Rattus norvegicus	124-129
8738659-3	1996	Determination of the cDNA sequence of his alpha-GAL A gene revealed substitution of a G to A in codon 301, resulting in a glutamine rather than an arginine residue.	Arginine	147-155	galactosidase alpha	Homo sapiens	42-53
8609432-3	1996	Cloning and sequencing of Fc gamma RIIIa-encoding cDNA derived from an apparently heterozygous donor showed one single nucleotide substitution at position 230 (T-->G), which was responsible for a leucine (L)-->arginine (R) substitution at position 48 in the first extracellular Ig-like domain (EC1) of Fc-gamma RIIIa and caused a higher electrophoretic mobility of Fc gamma RIIIa.	Arginine	210-218	Fc gamma receptor IIIa	Homo sapiens	26-40
8601326-3	1996	The other two subjects were homozygous for different missense mutations: CGT(Arg) to TGT(Cys) at codon 515 (R515C) and G365R, respectively.	Arginine	77-80	UDP glycosyltransferase 8	Homo sapiens	73-76
8743573-3	1996	The protease hydrolyzed the native storage globulins of soybean seeds, such as the alpha subunit of beta-conglycinin, at a pair of arginine residues, Arg126-Arg127.	Arginine	131-139	alpha subunit of beta conglycinin	Glycine max	83-116
8636380-5	1996	Direct sequencing of the proinsulin gene exon 3 showed a heterozygous point mutation (CGT--&gt;CAT) resulting in the substitution of Arg--&gt;His in position 65 (corresponding to the AC cleavage site) in the index case, his mother, and his maternal grandmother.	Arginine	133-136	UDP glycosyltransferase 8	Homo sapiens	86-89
8729973-5	1996	Two of 17 carcinomas showed Ki-ras mutations, both in codon 12 (gly --&gt; lys and gly --&gt; arg).	Arginine	94-97	KRAS proto-oncogene, GTPase	Homo sapiens	28-34
8615793-4	1996	Only one of these arginine residues, arginine-122, is conserved in liver FABP, whereas the other arginine, at position 102, is replaced by a threonine.	Arginine	18-26	fatty acid binding protein 2	Rattus norvegicus	73-77
8615793-4	1996	Only one of these arginine residues, arginine-122, is conserved in liver FABP, whereas the other arginine, at position 102, is replaced by a threonine.	Arginine	37-45	fatty acid binding protein 2	Rattus norvegicus	73-77
8615793-4	1996	Only one of these arginine residues, arginine-122, is conserved in liver FABP, whereas the other arginine, at position 102, is replaced by a threonine.	Arginine	37-45	fatty acid binding protein 2	Rattus norvegicus	73-77
8621424-5	1996	Here we show that the binding site of NT-3 to its non-preferred receptors TrkA and TrkB is dominated by two positively charged residues, Arg-31 and His-33, previously shown to constitute a main determinant of binding to p75LNGFR.	Arginine	137-140	neurotrophin 3	Homo sapiens	38-42
8648190-7	1996	Adhesion to fibronectin and vitronectin was found to be divalent cation- and arginine-glycine-aspartic acid-dependent, and could be blocked by antibodies to beta 1 or alpha 5, and alpha v or alpha v beta 5, respectively.	Arginine	77-85	vitronectin	Homo sapiens	28-39
8724849-7	1996	Another novel repeat composed of alternating Arg and Glu was identified in KIAA0182.	Arginine	45-48	Gse1 coiled-coil protein	Homo sapiens	75-83
8626723-5	1996	Interestingly, this mutation completely abolished Shc phosphorylation by the IR in vivo whereas mutation of the arginine in the FLVRES motif of the Shc SH2 domain did not affect Shc phosphorylation by insulin.	Arginine	112-120	SHC adaptor protein 1	Homo sapiens	148-151
8626723-5	1996	Interestingly, this mutation completely abolished Shc phosphorylation by the IR in vivo whereas mutation of the arginine in the FLVRES motif of the Shc SH2 domain did not affect Shc phosphorylation by insulin.	Arginine	112-120	SHC adaptor protein 1	Homo sapiens	148-151
8632894-3	1996	The phosphate group of phosphotyrosine interacts directly with a conserved arginine residue in the FLVRES motif of the SH2 domain, R175 in v-Src.	Arginine	75-83	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	141-144
8576219-5	1996	The S100 beta- stimulated nitrite production was blocked by cycloheximide and by the NOS inhibitor N-nitro-L-arginine methylester, but not by the inactive D-isomer of the inhibitor.	Arginine	107-117	S100 calcium binding protein B	Rattus norvegicus	4-13
8769716-4	1996	The case showed CAT at codon 273 instead of wild-type CGT, substituting the encoded amino acid form histidine to arginine.	Arginine	113-121	UDP glycosyltransferase 8	Homo sapiens	54-57
8720601-8	1996	Intravenous glucose and arginine-stimulated insulin were reduced to 15% of preoperative values.	Arginine	24-32	insulin	Canis lupus familiaris	44-51
9080192-7	1996	CONCLUSIONS: The resulting model of the Rev34-50-RBE complex predicts that although no single arginine sidechain is responsible for complex formation, residues Arg2, Arg5 and Arg11 are more important for binding than the other arginine residues in the peptide.	Arginine	227-235	arginase 2	Homo sapiens	160-164
8903674-3	1996	Pretreatment with 30 mg/kg of NG-nitro-L-arginine methylester (L-NAME), an inhibitor of NO synthase, accelerated increases of the TBARS level and myeloperoxidase (MPO) activity in the injured tissue and caused deterioration of hind limb motor function after SCI, suggesting that NO formation by constitutive NO synthase (c-NOS) has a protective effect against cellular damage resulting from ischemia-reperfusion after SCI.	Arginine	41-49	nitric oxide synthase 3	Rattus norvegicus	321-326
8557257-2	1996	The two affected sisters are homozygous for a T to G transversion in codon 699 of the PDEB gene, leading to the substitution of a leucine by an arginine residue.	Arginine	144-152	phosphodiesterase 6B	Homo sapiens	86-90
8550313-13	1996	Cell adhesion to fibronectin and vitronectin was inhibited by peptides containing the Arg-Gly-Asp sequence.	Arginine	86-89	vitronectin	Homo sapiens	33-44
8530633-2	1995	Affected individuals have a single base substitution in exon 8 of CYP11B1 gene, codon 448, from CGC (arginine) to CAC (histidine) (R448H), a mutation that abolishes enzyme activity completely.	Arginine	101-109	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	66-73
8746786-6	1995	Third, all IFN-tau, as well as the related IFN-omega, possess a Gly at position 126 (rather than the equivalent Arg on MuIFN-beta and IFN-alpha) that will impair an extensive hydrogen bonding interaction between helix D and loop AB.	Arginine	112-115	interferon-tau-like	Bos taurus	11-18
8587245-9	1995	L-arginine reduced the number of PCNA positive nuclei in remnant glomeruli, and Western blot Analysis of glomerular proteins also showed that L-arginine reduced PCNA expression.	Arginine	0-10	proliferating cell nuclear antigen	Rattus norvegicus	33-37
8587245-9	1995	L-arginine reduced the number of PCNA positive nuclei in remnant glomeruli, and Western blot Analysis of glomerular proteins also showed that L-arginine reduced PCNA expression.	Arginine	142-152	proliferating cell nuclear antigen	Rattus norvegicus	33-37
8587245-9	1995	L-arginine reduced the number of PCNA positive nuclei in remnant glomeruli, and Western blot Analysis of glomerular proteins also showed that L-arginine reduced PCNA expression.	Arginine	142-152	proliferating cell nuclear antigen	Rattus norvegicus	161-165
7561101-7	1995	Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154.	Arginine	155-163	CD44 molecule (Indian blood group)	Homo sapiens	47-51
7561101-7	1995	Sequence analysis of wild-type CEM and CEM-NKR CD44 cDNA demonstrated a G to A point mutation at position 575 in the CD44 cDNA of CEM-NKR, resulting in an arginine to histidine mutation at aa position 154.	Arginine	155-163	CD44 molecule (Indian blood group)	Homo sapiens	117-121
7548057-8	1995	The best inhibitors of APC and factor Xa contained Arg at the P3 position in place of Thr352, with 2- and 5-fold increases in inhibition rates, respectively.	Arginine	51-54	coagulation factor X	Homo sapiens	31-40
7573407-4	1995	When endothelial cells were stimulated with bradykinin and ATP in the presence of 100 microM L-arginine, we observed a rapid and transient rise in intracellular Ca2+ concentration ([Ca2+]i) from 50 +/- 8 nM to 698 +/- 74 and 637 +/- 53 nM, respectively, and a rapid and transient rise in NO production from a basal level of 37 pmol.min-1.mg protein-1 to 256 and 275 pmol.min-1.mg protein-1, respectively.	Arginine	93-103	kininogen 1	Bos taurus	44-54
8571304-5	1995	We found in the second family a previously described nonsense mutation: 584 Arg to stop codon in exon 17 of the GPIIb gene.	Arginine	76-79	integrin subunit alpha 2b	Homo sapiens	112-117
7627960-11	1995	NAT2 alleles with nucleic acid substitutions C282T (silent), C481T (silent), and A803G (Lys268--&gt;Arg) expressed recombinant NAT2 allozymes that did not have significant reductions in the metabolic activations of N-hydroxyarylamines and N-hydroxyarylamides.	Arginine	100-103	N-acetyltransferase 2	Homo sapiens	0-4
7627960-11	1995	NAT2 alleles with nucleic acid substitutions C282T (silent), C481T (silent), and A803G (Lys268--&gt;Arg) expressed recombinant NAT2 allozymes that did not have significant reductions in the metabolic activations of N-hydroxyarylamines and N-hydroxyarylamides.	Arginine	100-103	N-acetyltransferase 2	Homo sapiens	127-131
7627974-3	1995	To study the role of N-ras-activating mutations in the regulation of myeloma tumor growth, we introduced a constitutively active N-ras cDNA containing a glutamine to arginine (CAA-CGA) amino acid substitution at codon 61 into the interleukin 6 (IL-6)-dependent myeloma cell line ANBL6.	Arginine	166-174	NRAS proto-oncogene, GTPase	Homo sapiens	129-134
7620566-3	1995	Internal Arg/Lys residues that become C-terminal upon proteolysis or zymogen activation, such as in the two-chain form of tissue plasminogen activator, may also be removed from the mature protein.	Arginine	9-12	chromosome 20 open reading frame 181	Homo sapiens	122-150
7789519-2	1995	By site-directed mutagenesis of the cloned human glucose-6-phosphate dehydrogenase cDNA, lysine 205 (the residue that after reacting with pyridoxal-5"-phosphate renders inactive enzyme) was mutated to threonine (K205T) to remove the amino group, or to arginine (K205R) to displace the position of the amino group, in order to analyze the role of its nucleophilic group in position epsilon.	Arginine	252-260	glucose-6-phosphate dehydrogenase	Homo sapiens	49-82
7890620-9	1995	The contribution of the Arg-8 side chain is minor, but significant for cystatin C interaction with cathepsin B.	Arginine	24-27	cathepsin B	Homo sapiens	99-110
7887887-0	1995	The cardiac myosin heavy chain Arg-403--&gt;Gln mutation that causes hypertrophic cardiomyopathy does not affect the actin- or ATP-binding capacities of two size-limited recombinant myosin heavy chain fragments.	Arginine	31-34	major histocompatibility complex, class I, C	Homo sapiens	12-30
7889175-0	1995	Missense mutation in CYP11B1 (CGA[Arg-384]--&gt;GGA[Gly]) causes steroid 11 beta-hydroxylase deficiency.	Arginine	34-37	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	21-28
7889175-4	1995	We detected an additional previously uncharacterized mutation: R384G mutation, a single C--&gt;G base substitution in the codon 384 of the exon 7 changing an arginine (CGA) to a glycine (GGA) by sequencing the CYP11B1 gene of Japanese siblings with 11 beta-OHD.	Arginine	158-166	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	210-217
7735837-2	1995	The presence of a lysine instead of an arginine in the peptides derived from C3G appears to be crucial for this specificity towards c-Crk.	Arginine	39-47	Rap guanine nucleotide exchange factor 1	Homo sapiens	77-80
7862673-0	1995	A single arginine residue determines species specificity of the human growth hormone receptor.	Arginine	9-17	growth hormone receptor	Homo sapiens	70-93
7836437-4	1995	We term the enzyme oligopeptidase M. Oligopeptidase M acts similarly to thimet oligopeptidase (EC 3.4.24.15) on bradykinin and several other peptides, but hydrolyzes neurotensin exclusively at the -Pro+Tyr- bond (the symbol + is used to indicate a scissile peptide bond) rather than the -Arg+Arg- bond.	Arginine	288-291	thimet oligopeptidase 1	Rattus norvegicus	72-93
7836437-4	1995	We term the enzyme oligopeptidase M. Oligopeptidase M acts similarly to thimet oligopeptidase (EC 3.4.24.15) on bradykinin and several other peptides, but hydrolyzes neurotensin exclusively at the -Pro+Tyr- bond (the symbol + is used to indicate a scissile peptide bond) rather than the -Arg+Arg- bond.	Arginine	292-295	thimet oligopeptidase 1	Rattus norvegicus	72-93
7537680-5	1995	The inhibition of nitric oxide (NO) synthase by NG-nitro-L-arginine methyl ester attenuated the gastroprotection and gastric hyperemia induced by CCK while the concurrent treatment with L-arginine, but not D-arginine restored the protective activity of CCK and the accompanying increase in gastric blood flow.	Arginine	57-67	cholecystokinin	Rattus norvegicus	146-149
7605205-2	1995	Ts 412 has a single base substitution (G100--&gt;A) leading to an amino acid replacement (Arg 25--&gt;Lys) in the NS1 protein.	Arginine	90-93	influenza virus NS1A binding protein	Homo sapiens	114-117
8608088-1	1995	The tetrapeptide, Arg-Gly-Asp-Ser (RGDS), which corresponds to a core sequence of cell adhesion proteins, was coimmobilized with insulin on to surface-hydrolyzed poly(methyl methacrylate) film.	Arginine	18-21	ral guanine nucleotide dissociation stimulator	Mus musculus	35-39
7738104-12	1995	NPL3 includes bipartite RNA recognition motifs (RRM) and a Gly-Arg repeat domain, as in several nucleolar proteins.	Arginine	63-66	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	0-4
7740449-2	1994	Previous studies indicated that an arginine residue located at position 34 of the inhibitor was cleaved by Factor Xa during the inhibition reaction.	Arginine	35-43	coagulation factor X	Homo sapiens	107-116
7740452-4	1994	alpha 1-antitrypsin Pittsburgh (Met358--&gt;Arg), a mutant of alpha 1-antitrypsin, is a potent inhibitor of plasma kallikrein and thrombin.	Arginine	44-47	kallikrein related peptidase 4	Homo sapiens	115-125
7961684-3	1994	Replacement of the native P14 Thr-333 residue by an Arg (Thr-333--&gt;Arg) resulted in complete loss of inhibitory activity toward tissue-type plasminogen activator and urokinase-type plasminogen activator.	Arginine	52-55	ribonuclease P/MRP subunit p14	Homo sapiens	26-29
7961684-3	1994	Replacement of the native P14 Thr-333 residue by an Arg (Thr-333--&gt;Arg) resulted in complete loss of inhibitory activity toward tissue-type plasminogen activator and urokinase-type plasminogen activator.	Arginine	70-73	ribonuclease P/MRP subunit p14	Homo sapiens	26-29
7947684-10	1994	In contrast, mutation of three nonconserved flanking His residues or a partially conserved Arg residue within the conserved motif to Ala allowed for complementation of the ole1 phenotype.	Arginine	91-94	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	172-176
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	240-248	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-60
7821177-5	1994	RESULTS: The frequency of DRB1*0301-DRB3*0201-DQA1*0501-DQB1*0201 haplotype was 43.9% in the IDDM patients and 7.1% in the control subjects (P &lt; 0.00001), reflecting the increased prevalence of DQA1*0501 susceptibility allele coding for arginine (Arg) in position 52 and DQB1*0201 susceptibility allele non-coding aspartic acid (Asp) at position 57.	Arginine	250-253	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	56-60
7803850-5	1994	Sequence analysis of the col-1 gene in the three temperature-sensitive mutants revealed that each allele of sqt-3 has a unique missense mutation causing arginine or glutamic acid to replace glycine in a Gly-X-Y triple helical domain.	Arginine	153-161	Cuticle collagen 1	Caenorhabditis elegans	108-113
7955906-12	1994	Urinary excretion of cyclic GMP increased by 65.4% after L-arginine and by 25.1 after placebo.	Arginine	57-67	5'-nucleotidase, cytosolic II	Homo sapiens	28-31
7955906-19	1994	Platelet intracellular cyclic GMP was increased by 43.0% after L-arginine, but not after placebo (P &lt; 0.05).	Arginine	63-73	5'-nucleotidase, cytosolic II	Homo sapiens	30-33
7988299-0	1994	Arginine-induced insulin release in glucokinase-deficient subjects.	Arginine	0-8	glucokinase	Homo sapiens	36-47
7988299-14	1994	CONCLUSIONS: beta-cell secretory increment in response to arginine was found to be in the normal range in GCK-deficient subjects.	Arginine	58-66	glucokinase	Homo sapiens	106-109
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	163-171	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	46-50
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	163-171	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	124-131
8052313-5	1994	This motif includes the essential active-site residues Cys 12 and Arg 18 and bears striking similarities to the active-site motif recently described in the structure of human PTP1B.	Arginine	66-69	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	175-180
7527422-3	1994	The proteolytic cleavage of GDA-J/F3 protein by trypsin, which also caused sperm decapitation, indicated the presence of peptide bonds involving the carboxyl groups of the basic amino acids, arginine and/or lysine.	Arginine	191-199	guanine deaminase	Homo sapiens	28-31
8045889-8	1994	In addition to the finding of specific regulation of gene expression by the end products of their respective pathways, it was found that the levels of anthranilate synthase and alpha-isopropylmalate synthase were reduced upon growth in the presence of amino acids of other families, such as L-alanine, L-proline, or L-arginine.	Arginine	316-326	anthranilate synthase component I	Methanothermobacter marburgensis str. Marburg	151-172
7913883-8	1994	Both mutations result in the substitution of an arginine residue for a glycine at position 380 of the mature protein, which is in the transmembrane domain of FGFR3.	Arginine	48-56	fibroblast growth factor receptor 3	Homo sapiens	158-163
8027078-8	1994	Mutational analysis of the amino acids located just before the site of cleavage, confirmed the importance of arginines at P-1 and P-4.	Arginine	109-118	crystallin gamma F, pseudogene	Homo sapiens	122-133
7948099-4	1994	Here we show that two lysine residues in the antibody-combining region of B3(Fv)-PE38 can be replaced with arginines, with only a small loss of cytotoxicity and no change in specificity.	Arginine	107-116	immunoglobulin kappa variable 4-1	Homo sapiens	74-85
7525477-4	1994	PMA induced a time-, dose-, and L-arginine-dependent increase in cyclic GMP, which could be inhibited by dexamethasone or actinomycin D.	Arginine	32-42	5'-nucleotidase, cytosolic II	Homo sapiens	72-75
8207810-6	1994	This arginine- and proline-rich sequence is probably important in anchoring the first transmembrane domain in the plasma membrane, since these mutated LMP1s had altered stability and cell membrane localization.	Arginine	5-13	PDZ and LIM domain 7	Homo sapiens	151-155
7725728-8	1994	All mutations detected were adenine to guanine transitions at the second position of N-ras codon 61, resulting in a conversion from glutamine to arginine.	Arginine	145-153	NRAS proto-oncogene, GTPase	Homo sapiens	85-90
8013641-4	1994	These analyses suggest two basic residues in the arginine cluster region of P-450, which are present in P-450s 2B1 and 2E1 but are absent in P-450 1A1, as potential binding sites for cytochrome b5.	Arginine	49-57	cytochrome b5 type A	Rattus norvegicus	183-196
7515279-3	1994	We have recently compared six different genetic variants of apo A-I and found that the apo A-I (Pro 165--&gt;Arg) mutant is defective in promoting cellular cholesterol efflux from murine adipocytes and peritoneal macrophages and we have proposed that this region of apo A-I may be involved in their interaction with cells.	Arginine	109-112	apolipoprotein A-I	Mus musculus	60-67
7515279-3	1994	We have recently compared six different genetic variants of apo A-I and found that the apo A-I (Pro 165--&gt;Arg) mutant is defective in promoting cellular cholesterol efflux from murine adipocytes and peritoneal macrophages and we have proposed that this region of apo A-I may be involved in their interaction with cells.	Arginine	109-112	apolipoprotein A-I	Mus musculus	87-94
7515279-3	1994	We have recently compared six different genetic variants of apo A-I and found that the apo A-I (Pro 165--&gt;Arg) mutant is defective in promoting cellular cholesterol efflux from murine adipocytes and peritoneal macrophages and we have proposed that this region of apo A-I may be involved in their interaction with cells.	Arginine	109-112	apolipoprotein A-I	Mus musculus	87-94
7920641-6	1994	Two mutations were identified in MTHFR-deficient patients: a missense mutation (Arg to Gln), in a residue conserved in bacterial enzymes, and a nonsense mutation (Arg to Ter).	Arginine	80-83	methylenetetrahydrofolate reductase	Homo sapiens	33-38
7920641-6	1994	Two mutations were identified in MTHFR-deficient patients: a missense mutation (Arg to Gln), in a residue conserved in bacterial enzymes, and a nonsense mutation (Arg to Ter).	Arginine	163-166	methylenetetrahydrofolate reductase	Homo sapiens	33-38
7513741-6	1994	Removal of the C-terminal arginine from C3a and C5a abolished their activity on skin mast cells.	Arginine	26-34	complement C3	Homo sapiens	40-43
8182541-7	1994	However, co-administration of delta-1 or delta-2 opioid receptor antagonists with the mu opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 resulted in a dramatic reduction in analgesic responses to SNF9007.	Arginine	136-139	opioid receptor, delta 1	Mus musculus	30-64
7513610-6	1994	In cell adhesion assays, the 69-6-5 mAb was able to inhibit strongly in a dose-dependent manner arginine-glycine-aspartic acid-mediated adhesion of HT29-D4 cells to vitronectin, fibronectin, or ProNectin F but not to laminin or collagen.	Arginine	96-104	vitronectin	Homo sapiens	165-176
8142399-14	1994	The P1 Arg and Lys mutants also significantly inhibited thrombin, factor XIa, activated protein C, plasmin, factor XIIa, kallikrein, and bovine trypsin and chymotrypsin but did not inhibit tissue factor.factor VIIa, t-PA, or HLE.	Arginine	7-10	coagulation factor II, thrombin	Bos taurus	56-119
8118045-8	1994	This results suggests that arginine 198 in human G6PD, possibly located within the putative G6P binding domain, may play an important role in binding the substrate G6P.	Arginine	27-35	glucose-6-phosphate dehydrogenase	Homo sapiens	49-53
7905794-0	1994	Inhibition of CD4+ T lymphocyte binding to fibronectin and immune-cell accumulation in inflammatory sites by non-peptidic mimetics of Arg-Gly-Asp.	Arginine	134-137	CD4 antigen	Mus musculus	14-17
8294457-0	1994	Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues.	Arginine	129-137	thimet oligopeptidase 1	Rattus norvegicus	54-74
8294457-1	1994	A metalloendopeptidase that selectively cleaves doublets of basic amino acids on the amino-terminal side of arginine residues was purified to homogeneity from rat testes and analyzed further.	Arginine	108-116	thimet oligopeptidase 1	Rattus norvegicus	2-22
8294457-8	1994	The enzyme produced such a cleavage at the Arg-Lys doublet of somatostatin 28 (Km = 43 microM), at the Arg-Arg doublet of dynorphin A (Km = 6.45 microM) and atrial natriuretic factor (Km = 6.25 microM), and at the Lys-Arg doublet of preproneurotensin-(154-170) (Km = 17.3 microM).	Arginine	43-46	natriuretic peptide A	Rattus norvegicus	157-182
8276107-1	1994	We made a mutated progastrin cDNA construct that contains a cleavage site (-Arg(-4)-Arg(-3)-Lys(-2)-Arg-1) specific for the Kex2-like endoprotease furin, located ahead of the bioactive gastrin.	Arginine	76-79	gastrin	Cricetulus griseus	21-28
8276107-1	1994	We made a mutated progastrin cDNA construct that contains a cleavage site (-Arg(-4)-Arg(-3)-Lys(-2)-Arg-1) specific for the Kex2-like endoprotease furin, located ahead of the bioactive gastrin.	Arginine	84-87	gastrin	Cricetulus griseus	21-28
8276115-6	1994	Additionally, PC1 cleaves proDyn at a single arginine residue to yield an 8 kDa product and the C-peptide.	Arginine	45-53	proprotein convertase subtilisin/kexin type 1	Mus musculus	14-17
8000074-3	1994	This partial sequence, homologous to human CPE, CPM, and CPN, contained the conserved arginine and zinc binding domains.	Arginine	86-94	carboxypeptidase N subunit 1	Homo sapiens	57-60
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Arginine	74-77	UDP glycosyltransferase 8	Homo sapiens	79-82
7866410-0	1994	Marked zinc activation of ester hydrolysis by a mutation, 67-His (CAT) to Arg (CGT), in the active site of human carbonic anhydrase I.	Arginine	74-77	carbonic anhydrase 1	Homo sapiens	113-133
8267592-1	1993	Arginine-specific mono(ADP-ribosyl)transferase purified from rabbit skeletal muscle catalyzes stoichiometric ADP-ribosylation of the intermediate filament protein, desmin.	Arginine	0-8	desmin	Oryctolagus cuniculus	164-170
7504656-4	1993	The Arg-Gly-Asp (RGD)-containing peptide, a major adhesive ligand of ECM, is present in various plasma and matrix glycoproteins, such as FN and VN.	Arginine	4-7	vitronectin	Mus musculus	144-146
8218226-6	1993	Like PACE, PACE4 was able to process pro-vWF to its mature form, and efficient cleavage required both the P4 arginine and the P2 lysine.	Arginine	109-117	proprotein convertase subtilisin/kexin type 6	Homo sapiens	11-16
8025347-10	1993	The "ligand-binding pocket" of GP IIb-IIIa contains at least three sequences essential for ligand binding; fibrinogen also binds to the activated complex through identified domains, one of which, the Arg-Gly-Asp (RGD) sequence, is also found in vWF and the other adhesive proteins able to support platelet aggregation.	Arginine	200-203	integrin subunit alpha 2b	Homo sapiens	31-37
8392085-5	1993	This shows that Arg 271 directly affects the affinity of the VDR for its ligand and its conversion to leucine decreases its affinity for 1,25(OH)2D3 by a factor of 1,000.	Arginine	16-19	vitamin D receptor	Homo sapiens	61-64
8392085-6	1993	Arg 271 is located immediately 3-prime to a 30 amino acid segment (VDR amino acids 241-270) that is conserved among members of the steroid/thyroid/retinoid hormone receptor superfamily.	Arginine	0-3	vitamin D receptor	Homo sapiens	67-70
8515424-5	1993	The binding site is found in the C-terminal region of bv-PLA2, forming part of the proposed interfacial surface for binding to aggregated substrates, and comprises two distinct regions: (i) a hydrophobic cavity delimited by the C-terminal beta-sheet and the antiparallel beta-sheet, which interacts with the apolar zone of MLD, and (ii) a cationic site made up of residues Arg-58 and Lys-94, which interacts with the polar zone.	Arginine	373-376	phospholipase A2 group IIA	Homo sapiens	57-61
8318017-5	1993	mPC1 and hPC1 displayed identical cleavage selectivity towards a number of fluorogenic substrates, and those incorporating an Arg at the P4 site were most favoured.	Arginine	126-129	proprotein convertase subtilisin/kexin type 1	Mus musculus	0-4
8509361-4	1993	Although the severity of both NARP and SNE disease were correlated with the quantity of the ATPase 6leu156--&gt;arg mutation in each patient, the mutation could not be shown to alter F1F0-ATP synthase activity.	Arginine	112-115	neuronal pentraxin 2	Homo sapiens	30-34
8100215-7	1993	Analysis of the coding sequence within exon 1, the most 5" exon within the lysyl oxidase gene, revealed that the PstI RFLP was due to a G--&gt;A transition resulting in a nonconservative arginine to glutamine substitution proximal to a propeptide cleavage domain encoded by exon 1 of the lysyl oxidase gene.	Arginine	187-195	lysyl oxidase	Homo sapiens	75-88
8100215-7	1993	Analysis of the coding sequence within exon 1, the most 5" exon within the lysyl oxidase gene, revealed that the PstI RFLP was due to a G--&gt;A transition resulting in a nonconservative arginine to glutamine substitution proximal to a propeptide cleavage domain encoded by exon 1 of the lysyl oxidase gene.	Arginine	187-195	lysyl oxidase	Homo sapiens	288-301
7684041-3	1993	Sheep trichohyalin has a molecular weight of 201,172 and is characterized by the presence of a high proportion of glutamate, arginine, glutamine, and leucine residues, together totaling more than 75% of the amino acids.	Arginine	125-133	trichohyalin	Ovis aries	6-18
8491783-6	1993	The synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, that contains the Arg-Gly-Asp (RGD) integrin recognition site, reversibly inhibited entactin-mediated blastocyst outgrowth in a dose-dependent manner, but had no effect on laminin-mediated outgrowth.	Arginine	27-30	nidogen 1	Mus musculus	132-140
8491783-6	1993	The synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro, that contains the Arg-Gly-Asp (RGD) integrin recognition site, reversibly inhibited entactin-mediated blastocyst outgrowth in a dose-dependent manner, but had no effect on laminin-mediated outgrowth.	Arginine	66-69	nidogen 1	Mus musculus	132-140
7683462-0	1993	The cell attachment and spreading activity of vitronectin is dependent on the Arg-Gly-Asp sequence.	Arginine	78-81	vitronectin	Homo sapiens	46-57
7683462-2	1993	The cell attachment activity of vitronectin has been ascribed to an Arg-Gly-Asp (RGD) sequence near the amino terminus.	Arginine	68-71	vitronectin	Homo sapiens	32-43
8471773-4	1993	From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg).	Arginine	135-138	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
8471773-4	1993	From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg).	Arginine	174-177	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
8471773-4	1993	From these 43 samples, we have identified five different types of nucleotide substitutions in the G6PD gene: at cDNA 1388 from G to A (Arg to His); at cDNA 1376 from G to T (Arg to Leu); at cDNA 1024 from C to T (Leu to Phe); at cDNA 392 from G to T (Gly to Val); at cDNA 95 from A to G (His to Arg).	Arginine	174-177	glucose-6-phosphate dehydrogenase	Homo sapiens	98-102
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	32-35	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8462689-1	1993	We have recently shown that the Arg/Lys-X-Lys/Arg-Arg or Arg/Lys-X-X-X-Lys/Arg-Arg sequence serves as a signal for cleavage of precursor proteins within the constitutive secretory pathway, and this cleavage is catalyzed by furin, a mammalian homolog of the yeast Kex2 protease.	Arginine	46-49	kexin KEX2	Saccharomyces cerevisiae S288C	263-267
8471039-3	1993	NN precedes NT and is separated from it by a Lys-Arg sequence.	Arginine	49-52	neurotensin	Rattus norvegicus	0-2
8471039-11	1993	Because two of the antigenic sequences, i.e. NN and the NN-like sequence, start with a lysine residue that is essential for recognition by their respective antisera, a micromethod by which trypsin specifically cleaves at arginine residues was developed.	Arginine	221-229	neurotensin	Rattus norvegicus	45-47
8496014-1	1993	Bombesin (Bn, pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2) is one of the most potent peptides, possessing a variety of physiological and pharmacological functions.	Arginine	23-26	gastrin releasing peptide	Homo sapiens	0-8
8481357-5	1993	Affected individuals have a single base substitution in exon 8 of CYP11B1, codon 448, from CGC (arginine) to CAC (histidine).	Arginine	96-104	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	66-73
8383676-6	1993	The 4 Lys residues (Lys273, Lys277, Lys293, and Lys294) in this region of CDC34 were substituted by arginine either singly or in combination to produce a set of Cdc34 mutants.	Arginine	100-108	SCF E2 ubiquitin-protein ligase catalytic subunit CDC34	Saccharomyces cerevisiae S288C	161-166
8485050-4	1993	Two primers for polymerase chain reaction (PCR) were then designed, and a 394 bp PCR product was generated and sequenced, indicating that a stop codon (TGA) was substituted for an Arg codon (CGA) at amino acid position 584 of GPIIb, and resulted in a premature termination of translation and production of a shortened protein.	Arginine	180-183	integrin subunit alpha 2b	Homo sapiens	226-231
8436127-0	1993	Unidirectional arginine transport in reconstituted plasma-membrane vesicles from yeast overexpressing CAN1.	Arginine	15-23	arginine permease CAN1	Saccharomyces cerevisiae S288C	102-106
7688808-5	1993	When the cerebellum supernatant was incubated with both exogenous L-arginine (nitric oxide (NO) donor) and NADPH, and irradiated by an RF burst-type EM field, the production of cyclic GMP was increased significantly from a level of 21-22 nmol min-1 (g tissue)-1 to 25-26 nmol min-1 (g tissue)-1.	Arginine	66-76	5'-nucleotidase, cytosolic II	Homo sapiens	184-187
8480530-1	1993	Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines.	Arginine	81-91	colony stimulating factor 2	Rattus norvegicus	219-267
8369751-1	1993	A high-performance liquid chromatographic method to determine (Me)Arg-Lys-Pro-Trp-tert-Leu-Leu (NT-2) with neurotensin (NT) activity in rat plasma was developed and a pharmacokinetic study was performed in rats.	Arginine	66-69	neurotensin	Rattus norvegicus	107-118
8495370-6	1993	The CBV increases after NPY reappeared following a 15-min administration of 0.25 mg/kg/min of L-arginine, which is a precursor of nitric oxide.	Arginine	94-104	neuropeptide Y	Felis catus	24-27
7679657-1	1993	When islets were cultured with interleukin-1 beta (1 or 100 pmol/l) for 12 h in arginine-containing medium, cyclic GMP levels were increased 1.6- and 4.5-fold respectively.	Arginine	80-88	5'-nucleotidase, cytosolic II	Homo sapiens	115-118
7679657-2	1993	The arginine analogue, N-omega-nitro-L-arginine methyl ester, which blocks nitric oxide formation and partially reverses inhibition of insulin secretion by 100 pmol/l interleukin-1 beta, largely, but not completely, blocked generation of cyclic GMP.	Arginine	4-12	5'-nucleotidase, cytosolic II	Homo sapiens	245-248
7685968-5	1993	This inhibition was not observed with a mutant form of the kinase (Lys--&gt;Arg at position 296) and it was reversed by antisense expression of the p68 gene.	Arginine	76-79	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	148-151
1464666-4	1992	Then, by screening Japanese diabetic patients using polymerase chain reaction--single strand conformation polymorphism (PCR-SSCP) and direct-sequencing strategies, we identified a missense mutation substituting arginine (AGG) for glycine (GGG) at position 261 in exon 7 of the glucokinase gene in a patient with early-onset non-insulin-dependent diabetes (NIDDM).	Arginine	211-219	glucokinase	Homo sapiens	277-288
1362222-0	1992	A new mutant transthyretin (Arg 10) associated with familial amyloid polyneuropathy.	Arginine	28-31	transthyretin	Homo sapiens	13-26
1448098-8	1992	The gene, named EGD1 (enhancer of GAL4 DNA binding), encodes a highly basic protein (21% lysine and arginine) with a predicted molecular mass of 16.5 kDa.	Arginine	100-108	Egd1p	Saccharomyces cerevisiae S288C	16-20
1454802-1	1992	The human pre-mRNA splicing factors SF2 and SC35 have similar electrophoretic mobilities, and both of them contain an N-terminal ribonucleoprotein (RNP)-type RNA-recognition motif and a C-terminal arginine/serine-rich domain.	Arginine	197-205	serine and arginine rich splicing factor 1	Homo sapiens	36-39
1332764-3	1992	Measurement of transferred NOEs and molecular modeling indicate that the side chain of the Asp(P3) residue may form a hydrogen bond with thrombin and, by doing so, it is brought near a positively-charged thrombin residue Arg(221A), thereby partially neutralizing the negative charge of an Asp residue at this site of protein substrates.	Arginine	221-224	coagulation factor II, thrombin	Bos taurus	204-212
1331047-6	1992	The two peptides, particularly IIFMGRVANP, directly enhanced the amidolytic activity of thrombin and Factor Xa on the synthetic substrate Boc-Ala-Gly-Arg-MCA (where Boc is t-butoxycarbonyl and MCA is 4-methylcoumarin), which corresponds to residues P3-P1 of the reactive site of antithrombin III, and also on other substrates due to increased Vmax.	Arginine	150-153	coagulation factor X	Homo sapiens	101-110
1284063-2	1992	Several integrins recognize as ligands proteins containing the Arg-Gly-Asp (RGD) sequence, such as fibronectin, vitronectin, and laminin.	Arginine	63-67	vitronectin	Homo sapiens	112-123
1429834-1	1992	The four nucleolar proteins NOP1, SSB1, GAR1, and NSR1 of Saccharomyces cerevisiae share a repetitive domain composed of repeat units rich in glycine and arginine (GAR domain).	Arginine	154-162	Hsp70 family ATPase SSB1	Saccharomyces cerevisiae S288C	34-38
1429834-1	1992	The four nucleolar proteins NOP1, SSB1, GAR1, and NSR1 of Saccharomyces cerevisiae share a repetitive domain composed of repeat units rich in glycine and arginine (GAR domain).	Arginine	154-162	Nsr1p	Saccharomyces cerevisiae S288C	50-54
1383690-8	1992	The ABL and ARG SH2 domains differ by only 10 of 91 amino acids, and the substitution of ABL-specific amino acids into either the amino- or carboxy-terminal half of the ARG SH2 domain was found to increase its affinity for BCR.	Arginine	12-15	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	89-92
1383690-8	1992	The ABL and ARG SH2 domains differ by only 10 of 91 amino acids, and the substitution of ABL-specific amino acids into either the amino- or carboxy-terminal half of the ARG SH2 domain was found to increase its affinity for BCR.	Arginine	169-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-7
1383690-8	1992	The ABL and ARG SH2 domains differ by only 10 of 91 amino acids, and the substitution of ABL-specific amino acids into either the amino- or carboxy-terminal half of the ARG SH2 domain was found to increase its affinity for BCR.	Arginine	169-172	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	89-92
1417490-8	1992	C3a(des)-Arg, C3, C4, and the C3a(des)-Arg-C3 ratio were correlated with Sepsis Severity Scores.	Arginine	9-12	complement C3	Homo sapiens	0-3
1326547-7	1992	Arg-7 and Arg-59 of the yeast phosphoglycerate mutase have been postulated to be substrate-binding residues based on the x-ray crystal structure.	Arginine	0-3	phosphoglycerate mutase	Saccharomyces cerevisiae S288C	30-53
1326547-7	1992	Arg-7 and Arg-59 of the yeast phosphoglycerate mutase have been postulated to be substrate-binding residues based on the x-ray crystal structure.	Arginine	10-13	phosphoglycerate mutase	Saccharomyces cerevisiae S288C	30-53
1326944-4	1992	Tetrapeptide RGDS (Arg-Gly-Asp-Ser), which blocks the interaction of ligands such as fibrinogen with platelet integrin alpha IIb beta 3 (GPIIb-IIIa), inhibited only the late-phase PtdIns(3,4)P2 accumulation that was associated with added Ca2+.	Arginine	19-22	integrin subunit alpha 2b	Homo sapiens	137-142
1445373-2	1992	DNA analysis of the variant allele revealed a nucleotide substitution (transition) of C to T at codon 314 (CGT-TGT), and this mutation resulted in the replacement of an arginine by a cysteine (R314C).	Arginine	169-177	UDP glycosyltransferase 8	Homo sapiens	107-110
1330642-4	1992	The cyclic GMP responses to bradykinin were suppressed with the same potency by L-arginine analogues in control and in forskolin-treated cells (IC50 of NG-monomethyl-L-arginine 2 microM, of nitro-L-arginine 0.7 microM).	Arginine	80-90	5'-nucleotidase, cytosolic II	Homo sapiens	11-14
1481381-7	1992	Attention is also drawn to the possible function of NO in the pituitary, in particular with regard to the arginine test which stimulates STH secretion.	Arginine	106-114	saitohin	Homo sapiens	137-140
1324289-6	1992	Removing L-arginine from the medium did not inhibit cytotoxicity or PGE2 secretion, but the listeriacidal activity specific to interferon-gamma plus lipopolysaccharide (LPS)-activated GM-CSF-derived macrophages was blocked by removal of L-arginine.	Arginine	237-247	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	184-190
1319855-6	1992	In contrast, myocardial ischemia plus reperfusion cats treated with L-arginine exhibited a reduced area of cardiac necrosis (16 +/- 2% versus 41 +/- 5% of area at risk, p less than 0.01), lower myeloperoxidase activity in the ischemic region (0.3 +/- 0.08 versus 0.8 +/- 0.10 units/100 mg tissue, p less than 0.05), and significant preservation of acetylcholine- (p less than 0.01) and A-23187- (p less than 0.01) induced endothelial-dependent relaxation.	Arginine	68-78	myeloperoxidase	Felis catus	194-209
1499287-7	1992	Cathepsin H had a pH and temperature optimum of 6.5 and 45 degrees C using Arg-MCA as a substrate, respectively, and was activated by sulfhydryl compounds and inhibited by cysteine protease inhibitors and metal compounds having high reactivities at cysteine residue.	Arginine	75-78	cathepsin H	Rattus norvegicus	0-11
1303241-3	1992	We have sequenced the tyrosinase-related protein-1 cDNA encoded at this locus from Light mice and found that it contains a single base alteration from wild-type, causing an Arg to Cys change in the protein.	Arginine	173-176	tyrosinase-related protein 1	Mus musculus	22-50
1569080-1	1992	We have recently demonstrated that the Arg-X-Lys/Arg-Arg sequence is a signal for precursor cleavage catalyzed by furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, within the constitutive secretory pathway.	Arginine	39-42	kexin KEX2	Saccharomyces cerevisiae S288C	190-194
1569080-1	1992	We have recently demonstrated that the Arg-X-Lys/Arg-Arg sequence is a signal for precursor cleavage catalyzed by furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, within the constitutive secretory pathway.	Arginine	49-52	kexin KEX2	Saccharomyces cerevisiae S288C	190-194
1569080-1	1992	We have recently demonstrated that the Arg-X-Lys/Arg-Arg sequence is a signal for precursor cleavage catalyzed by furin, a mammalian homologue of the yeast precursor-processing endoprotease Kex2, within the constitutive secretory pathway.	Arginine	49-52	kexin KEX2	Saccharomyces cerevisiae S288C	190-194
1517314-6	1992	Added arginine was removed by carboxypeptidase B, but very slowly.	Arginine	6-14	carboxypeptidase B1	Homo sapiens	30-48
1349863-0	1992	Dynorphin-degrading cysteine protease is highly specific for paired arginine residues.	Arginine	68-76	cathepsin B	Homo sapiens	20-37
1349863-2	1992	The cysteine protease of neuroblastoma cells cleaved only the bond between Arg-Arg residues.	Arginine	75-78	cathepsin B	Homo sapiens	4-21
1349863-2	1992	The cysteine protease of neuroblastoma cells cleaved only the bond between Arg-Arg residues.	Arginine	79-82	cathepsin B	Homo sapiens	4-21
1347429-7	1992	Three consecutive highly charged amino acid residues, Arg-Arg-Glu, present in both HRES-1 pep117-127 and HTLV-I gag p24 are likely to be the core of cross-reactive epitopes.	Arginine	54-57	HTLV-1 related endogenous sequence	Homo sapiens	83-89
1347429-7	1992	Three consecutive highly charged amino acid residues, Arg-Arg-Glu, present in both HRES-1 pep117-127 and HTLV-I gag p24 are likely to be the core of cross-reactive epitopes.	Arginine	58-61	HTLV-1 related endogenous sequence	Homo sapiens	83-89
1466286-1	1992	Kininase I-type carboxypeptidases remove a single C-terminal Arg residue from kinins.	Arginine	61-64	carboxypeptidase N subunit 1	Homo sapiens	0-10
1350267-7	1992	Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis.	Arginine	134-137	major histocompatibility complex, class II, DR beta 4	Homo sapiens	116-119
1350267-7	1992	Taken together, these results imply that the basic amino acids at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), are most important for determining the predisposition to autoimmune hepatitis.	Arginine	134-137	major histocompatibility complex, class II, DR beta 4	Homo sapiens	156-159
1531511-5	1992	Cathepsin B/L-like activity was determined with Bz-Val-Lys-Lys-Arg-AFC, elastase-like activity with MeOSuc-Ala-Ala-Pro-Val-AFC, tryptase-like activity with Z-Ala-Ala-Lys-AFC, trypsin-like activity with Z-Gly-Gly-Arg-AFC and dipeptidyl peptidase (DPP) IV-like activity with Ala-Pro-AFC.	Arginine	63-66	cathepsin B	Homo sapiens	0-11
1661670-0	1991	Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.	Arginine	27-35	platelet derived growth factor subunit B	Homo sapiens	4-16
1661670-3	1991	Two such PDGF-B chain residues, arginine 27 and isoleucine 30, have been identified by a site-directed mutagenesis programme.	Arginine	32-40	platelet derived growth factor subunit B	Homo sapiens	9-21
1839957-8	1991	Moreover, the attachment of IFN-gamma-treated Pam-T cells as well as non-treated cells to FN was blocked by the synthetic peptide Arg-Gly-Asp-Ser (RGDS), but not by the control peptide Arg-Gly-Glu-Ser.	Arginine	130-133	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	46-49
1954227-7	1991	Some enzymes of subclass I and in particular aspartate aminotransferase from Sulfolobus solfataricus, lack a positively charged residue, corresponding to Arg-292, which in pig cytosolic aspartate aminotransferase interacts with the distal carboxylate of the substrates (and determines the specificity towards dicarboxylic acids).	Arginine	154-157	histidinol-phosphate aminotransferase family protein	Saccharolobus solfataricus	45-71
1954227-7	1991	Some enzymes of subclass I and in particular aspartate aminotransferase from Sulfolobus solfataricus, lack a positively charged residue, corresponding to Arg-292, which in pig cytosolic aspartate aminotransferase interacts with the distal carboxylate of the substrates (and determines the specificity towards dicarboxylic acids).	Arginine	154-157	histidinol-phosphate aminotransferase family protein	Saccharolobus solfataricus	186-212
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	11-14	vitronectin	Homo sapiens	242-253
1720019-0	1991	A modified Arg-Asp-Val (RDV) peptide derived during the synthesis of Arg-Glu-Asp-Val (REDV), a tetrapeptide derived from an alternatively spliced site in fibronectin, inhibits the binding of fibrinogen, fibronectin, von Willebrand factor and vitronectin to activated platelets.	Arginine	69-72	vitronectin	Homo sapiens	242-253
1656975-0	1991	New mutant gene (transthyretin Arg 58) in cases with hereditary polyneuropathy detected by non-isotope method of single-strand conformation polymorphism analysis.	Arginine	31-34	transthyretin	Homo sapiens	17-30
1656975-6	1991	TTR Arg 58 is the first mutant TTR gene that has been detected by SSCP analysis.	Arginine	4-7	transthyretin	Homo sapiens	0-3
1656975-6	1991	TTR Arg 58 is the first mutant TTR gene that has been detected by SSCP analysis.	Arginine	4-7	transthyretin	Homo sapiens	31-34
1778986-1	1991	Three DNA constructs, pETB-40, 41, and 42, encoding human big endothelin-1 (ET-1) preceded by the specific recognition sequence (Ile-Glu-Gly-Arg) for the activated blood coagulation factor Xa (FXa), fused in frame to the N-terminal portion of beta Gal, were expressed in Escherichia coli.	Arginine	141-144	coagulation factor X	Homo sapiens	182-191
1923513-1	1991	Arg encodes a protein highly related to the c-abl gene product with regard to overall structural architecture as well as the amino acid sequences of their tyrosine kinase, and src-homologous 2 and 3 domains.	Arginine	0-3	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	44-49
1923513-8	1991	Analysis of arg expression in murine tissues revealed that arg, like c-abl, is widely expressed, further extending the similarities between the two genes, and suggesting that arg probably functions in signaling pathways fundamental to many cell types.	Arginine	59-62	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	69-74
1923513-8	1991	Analysis of arg expression in murine tissues revealed that arg, like c-abl, is widely expressed, further extending the similarities between the two genes, and suggesting that arg probably functions in signaling pathways fundamental to many cell types.	Arginine	59-62	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	69-74
1892810-4	1991	The ratio of kcat/KM obtained by using CBZ-Phe-Arg-MCA as substrate over that obtained with CBZ-Arg-Arg-MCA is 8.0 for the Val133Ala/Ser205Glu variant, while the equivalent values for wild-type papain and cathepsin B are 904 and 3.6, respectively.	Arginine	47-50	cathepsin B	Homo sapiens	205-216
1892810-8	1991	In particular, the activity toward CBZ-Arg-Arg-MCA is modulated by a group with a pKa of 5.51, a behavior that is also encountered in the case of cathepsin B but is absent with papain.	Arginine	39-42	cathepsin B	Homo sapiens	146-157
1872862-8	1991	Also, bovine protein Z cleaved by thrombin at Arg-365 bound DIP-thrombin with a 10-fold weaker affinity than did native bovine protein Z.	Arginine	46-49	coagulation factor II, thrombin	Bos taurus	34-42
1872862-8	1991	Also, bovine protein Z cleaved by thrombin at Arg-365 bound DIP-thrombin with a 10-fold weaker affinity than did native bovine protein Z.	Arginine	46-49	coagulation factor II, thrombin	Bos taurus	64-72
1713687-3	1991	Although no internal hydrophobic region, and thus no transmembrane domain, is apparent within the 120 amino acids of mature FKBP-13, a potential endoplasmic reticulum retention sequence (Arg-Thr-Glu-Leu) is found at its C terminus.	Arginine	187-190	FKBP prolyl isomerase 2	Homo sapiens	124-131
1892395-5	1991	These results clearly showed that the leader peptide with the Lys-Arg linker was recognized and specifically cleaved by the yeast KEX2 protease.	Arginine	66-69	kexin KEX2	Saccharomyces cerevisiae S288C	130-134
1710985-14	1991	Proteolytic cleavage at the putative mitochondrial processing protease-recognition site Arg(-2)-Ala(-1)-Glu(+1) would lead to the formation of a protein of 91391 Da, which is in good agreement with the estimated 90 kDa of mature Me2GlyDH [Wittwer, A.J.	Arginine	88-91	dimethylglycine dehydrogenase	Rattus norvegicus	229-237
1708943-0	1991	Novel effect of cyclicization of the Arg-Gly-Asp-containing peptide on vitronectin binding to platelets.	Arginine	37-40	vitronectin	Homo sapiens	71-82
2043465-8	1991	Following polymerase chain reaction (PCR) amplification, cloning and sequencing of exon 2 of spectrin alpha-gene in the father, we found the G----A substitution at position 2 of codon 22 (CGT----CAT; Arg----His).	Arginine	200-203	UDP glycosyltransferase 8	Homo sapiens	188-191
2017180-3	1991	A study of deletions and point mutations created in the 5" noncoding region of ARG3, ARG5,6, CAR1, and CAR2 genes shows that at least two regions, called BoxA and BoxB, are required for proper regulation of these genes by arginine and ARGR proteins.	Arginine	222-230	nuclear receptor subfamily 1 group I member 3	Homo sapiens	93-97
1882085-3	1991	In rabbit neuromedin U, the Arg16-Arg17 dibasic residue processing site that is found in pig and dog neuromedin U-25 is replaced by Arg-Gly, but this potential monobasic processing site is not utilized by cleavage enzyme(s) in the intestine.	Arginine	28-31	neuromedin-U-25	Oryctolagus cuniculus	10-22
1882085-3	1991	In rabbit neuromedin U, the Arg16-Arg17 dibasic residue processing site that is found in pig and dog neuromedin U-25 is replaced by Arg-Gly, but this potential monobasic processing site is not utilized by cleavage enzyme(s) in the intestine.	Arginine	28-31	neuromedin-U-25	Oryctolagus cuniculus	101-116
1367506-6	1991	After purification, the natural hGH was obtained by treating the precursors with the protease Factor Xa which cleaves after the arginine residue of the tetrapeptide IEGR.	Arginine	128-136	coagulation factor X	Homo sapiens	94-103
2025246-2	1991	Analysis of species specificity and of the epitope, determined using synthetic phosphopeptides, indicated that this antibody recognized the local phosphorylation-site sequence Thr-phosphoSer-Ala-Ala-Arg-Arg (residues 7-12 of GFAP).	Arginine	199-202	glial fibrillary acidic protein	Homo sapiens	225-229
2025246-2	1991	Analysis of species specificity and of the epitope, determined using synthetic phosphopeptides, indicated that this antibody recognized the local phosphorylation-site sequence Thr-phosphoSer-Ala-Ala-Arg-Arg (residues 7-12 of GFAP).	Arginine	203-206	glial fibrillary acidic protein	Homo sapiens	225-229
2005112-2	1991	E2 and E3 are synthesized as a precursor, p62, which is cleaved post-translationally after an Arg-His-Arg-Arg sequence.	Arginine	94-97	nucleoporin 62	Homo sapiens	42-45
2005112-2	1991	E2 and E3 are synthesized as a precursor, p62, which is cleaved post-translationally after an Arg-His-Arg-Arg sequence.	Arginine	102-105	nucleoporin 62	Homo sapiens	42-45
2005112-2	1991	E2 and E3 are synthesized as a precursor, p62, which is cleaved post-translationally after an Arg-His-Arg-Arg sequence.	Arginine	102-105	nucleoporin 62	Homo sapiens	42-45
2005112-4	1991	Cleavage of p62 was completely blocked by mutation of the proximal Arg residue to Phe, without affecting transport or surface expression of the spike protein.	Arginine	67-70	nucleoporin 62	Homo sapiens	12-15
1999399-7	1991	Substitution of the histidine in position 435 with glutamine, arginine, alanine, serine, or aspartic acid abolished the ability of cholesterol esterase to hydrolyze p-nitrophenyl butyrate and cholesterol [14C]oleate.	Arginine	62-70	carboxyl ester lipase	Rattus norvegicus	131-151
1706595-0	1991	Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which "buries" Ser-378, its site of phosphorylation by protein kinase A. Activation of blood platelets by thrombin was previously shown to specifically release protein kinase A, which in human plasma singles out and phosphorylates one protein, identified as vitronectin.	Arginine	27-30	vitronectin	Homo sapiens	51-62
1706595-0	1991	Endogenous cleavage of the Arg-379-Ala-380 bond in vitronectin results in a distinct conformational change which "buries" Ser-378, its site of phosphorylation by protein kinase A. Activation of blood platelets by thrombin was previously shown to specifically release protein kinase A, which in human plasma singles out and phosphorylates one protein, identified as vitronectin.	Arginine	27-30	vitronectin	Homo sapiens	365-376
1706595-5	1991	Cleavage of the Arg-379-Ala-380 bond results therefore in a conformationally distinct form of vitronectin in which Ser-378 is "buried".	Arginine	16-19	vitronectin	Homo sapiens	94-105
1899841-2	1991	Fragments of the HIV-1 Tat protein that contain the arginine-rich region of Tat bind specifically to a 3-nucleotide bulge in TAR RNA.	Arginine	52-60	Tat	Human immunodeficiency virus 1	23-26
1899843-0	1991	An arginine to lysine substitution in the bZIP domain of an opaque-2 mutant in maize abolishes specific DNA binding.	Arginine	3-11	regulatory protein opaque-2	Zea mays	60-68
1899843-4	1991	We have found that the o2-676 mutant protein does not show specific recognition of zein promoter fragments because of the substitution of a lysine residue for an arginine residue within the bZIP domain of o2-676.	Arginine	162-170	regulatory protein opaque-2	Zea mays	23-25
1899843-4	1991	We have found that the o2-676 mutant protein does not show specific recognition of zein promoter fragments because of the substitution of a lysine residue for an arginine residue within the bZIP domain of o2-676.	Arginine	162-170	regulatory protein opaque-2	Zea mays	205-207
1725346-5	1991	These data strongly suggest that, in LLC-PK1 cells, ET-1 stimulates formation of an endothelium-derived relaxing factor-like substance from L-arginine in a Ca(2+)-dependent fashion, which in turn activates soluble guanylate cyclase to elevate cellular cyclic GMP levels.	Arginine	140-150	endothelin-1	Sus scrofa	52-56
1719528-4	1991	It is found that Arg-17 is likely to be of importance in order to understand the way BPTI binds on trypsin.	Arginine	17-20	spleen trypsin inhibitor I	Bos taurus	85-89
2260635-10	1990	The results of these experiments show that attachment and spreading of bovine aortic endothelial and smooth muscle cells depend primarily on the presence of the Arg-Gly-Asp-Ser (RGDS) sequence in the recombinant fibronectin proteins.	Arginine	161-164	ral guanine nucleotide dissociation stimulator	Mus musculus	178-182
2238469-6	1990	Unlike any other HAs of influenza viruses, the H14 HAs contained lysine at the cleavage site between HA1 and HA2 instead of arginine.	Arginine	124-132	H1.4 linker histone, cluster member	Homo sapiens	47-50
2393028-9	1990	A sixth sample, resembling G6PD Mediterranean kinetically but with a slightly rapid electrophoretic mobility, was designated G6PD Andalus and was found to have a different mutation, a G----A transition at nucleotide 1361, producing an arginine-to-histidine substitution.	Arginine	235-243	glucose-6-phosphate dehydrogenase	Homo sapiens	27-31
2393028-9	1990	A sixth sample, resembling G6PD Mediterranean kinetically but with a slightly rapid electrophoretic mobility, was designated G6PD Andalus and was found to have a different mutation, a G----A transition at nucleotide 1361, producing an arginine-to-histidine substitution.	Arginine	235-243	glucose-6-phosphate dehydrogenase	Homo sapiens	125-129
2176554-1	1990	Arginine (0.5 and 1 mu mol) decreased by 14-17% rates of superoxide anion formation in two systems: HADH-phenazine methosulfate and hydroxylamine autooxidation with nitrotetrazolium blue.	Arginine	0-8	hydroxyacyl-CoA dehydrogenase	Rattus norvegicus	100-104
2168484-6	1990	Adding a lysine or arginine onto the spermine moiety increased the compound"s potency on the nACh-R with little effect on the NMDA-R. Because spermine is a component of PhTX, the effects of five polyamines were also studied.	Arginine	19-27	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	93-99
2198571-1	1990	We have previously described partial genomic sequences of arg, a human gene related to c-abl, and shown that it is expressed as a 12-kilobase transcript and is located at chromosome position 1q24-25.	Arginine	58-61	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-92
2198571-3	1990	Analysis of the predicted amino acid sequence of arg revealed that it is indeed closely related to that of c-abl.	Arginine	49-52	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	107-112
2198571-5	1990	In addition, arg, like c-abl, is expressed as two transcripts that result from a process of alternative splicing and encode alternative protein forms that differ only in their amino termini.	Arginine	13-16	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	23-28
16667583-1	1990	Arginase (EC 3.5.3.1) was purified to homogeneity from cytosol of soybean, Glycine max, axes by chromatographic separations on Sephadex G-200, DEAE-sephacel, hydroxyapatite, and arginine-affinity columns.	Arginine	178-186	arginase	Glycine max	0-8
2119388-6	1990	A gel containing D-Phe-D-Phe-Argal (an aldehyde derivative of arginine) was very effective in purifying tPA derived from cell culture media at small scale (milligrams) and at large (multi-grams).	Arginine	62-70	chromosome 20 open reading frame 181	Homo sapiens	104-107
1693616-0	1990	The presence of methionine or threonine at position 381 in vitronectin is correlated with proteolytic cleavage at arginine 379.	Arginine	114-122	vitronectin	Homo sapiens	59-70
2113511-3	1990	This base change (G to A) is thought to result in an amino acid change (Arg to Gln) in tyrosinase of the patient.	Arginine	72-75	tyrosinase	Homo sapiens	87-97
2190366-9	1990	The reactions were more likely related to the activation of complement, as indicated by the generation of C3a des Arg by the columns and an increase in C3a des Arg levels systemically.	Arginine	114-117	complement C3	Homo sapiens	106-109
2190366-9	1990	The reactions were more likely related to the activation of complement, as indicated by the generation of C3a des Arg by the columns and an increase in C3a des Arg levels systemically.	Arginine	160-163	complement C3	Homo sapiens	152-155
2320569-3	1990	Each of the protein in this family, which range from 47 to 83 residues, contains an Arg-Gly-Asp amino acid sequence found in protein ligands that binds to GPIIb-IIIa, a high (17 +/- 1%) cysteine content conserved in the primary sequence, and a homologous N-terminal region absent only in the echistatin isoforms.	Arginine	84-87	integrin subunit alpha 2b	Homo sapiens	155-160
2180962-8	1990	The anchorage-independent phenotype of c-sis-overexpressing cells was blocked by the cell adhesion sequence of fibronectin, Arg-Gly-Asp-Ser.	Arginine	124-127	platelet derived growth factor subunit B	Homo sapiens	39-44
2315322-2	1990	The unusually high number of serine, leucine, and arginine residues in secretin has precluded the use of oligonucleotides to screen cDNA libraries to isolate a secretin cDNA.	Arginine	50-58	secretin	Rattus norvegicus	71-79
2139352-5	1990	When we substituted a glycine for arginine into the ring portion of iso-rANP at position 36, so that there were only three amino acids different from the ring of rANP, biological activity of iso-rANP(23-39) was retained.	Arginine	34-42	natriuretic peptide A	Rattus norvegicus	72-76
2340183-3	1990	Cleavage of the chicken TGF-beta 2 precursor at a pentabasic Arg-Arg-Lys-Lys-Arg site would produce a 112-amino acid processed peptide differing by only one amino acid from the human TGF-beta 2 peptide.	Arginine	65-68	transforming growth factor beta 2	Homo sapiens	183-193
2122147-0	1990	Arginine and lysine product inhibition of bovine adrenomedullary carboxypeptidase H, a prohormone processing enzyme.	Arginine	0-8	carboxypeptidase E	Bos taurus	65-83
2122147-2	1990	In this study, CPH activity in the soluble and membrane fractions of enkephalin-containing bovine chromaffin granules was competitively inhibited by its products arginine and lysine.	Arginine	162-170	carboxypeptidase E	Bos taurus	15-18
2145621-3	1990	In contrast, the first, but not the second phase of arginine (10 mmol/l)-stimulated insulin release was significantly enhanced by ANF (1000 pmol/l; controls: 100%; 1000 pmol/l: 235%, P less than 0.05).	Arginine	52-60	natriuretic peptide A	Rattus norvegicus	130-133
2293362-0	1990	Coronary trapping of a complement activation product (C3a des-Arg) during myocardial reperfusion in open-heart surgery.	Arginine	62-65	complement C3	Homo sapiens	54-57
2293362-5	1990	From a preoperative value of 92 +/- 13 ng/ml, C3a des-Arg rose during CPB to a maximum of 1816 +/- 393 at the end of CPB.	Arginine	53-57	complement C3	Homo sapiens	46-49
2293362-5	1990	From a preoperative value of 92 +/- 13 ng/ml, C3a des-Arg rose during CPB to a maximum of 1816 +/- 393 at the end of CPB.	Arginine	53-57	carboxypeptidase B1	Homo sapiens	70-73
3096340-1	1986	A decapeptide corresponding to residues 35-44(-Thr-Ile-Glu-Asp-Ser-Tyr-Arg-Lys-Gln-Val-) of p21ras was synthesized.	Arginine	71-74	Harvey rat sarcoma virus oncogene	Mus musculus	92-98
33971157-1	2021	Peptidylarginine deiminase type III (PAD3) is an isozyme belonging to the PAD enzyme family that converts arginine to citrulline residue(s) within proteins.	Arginine	8-16	peptidyl arginine deiminase 3	Homo sapiens	37-41
33232463-7	2021	Mean +- SEM l-arginine concentration was 263 +- 9.76 mumol/L in supplement users homozygous for the minor allele of ARG1 rs2246012 (P = 0.004); it was 70.4 +- 25.6 mumol/L in unsupplemented participants homozygous for the minor allele of ARG2 rs3759757 (P = 0.03).	Arginine	12-22	arginase 2	Homo sapiens	238-242
33232463-8	2021	The ARG1 haplotype was significantly associated with blood l-arginine concentrations in supplement users (P = 0.046), whereas the combined ARG1/ARG2 haplotype was significantly associated with blood l-arginine concentrations in the cohort as a whole (P = 0.012).	Arginine	199-209	arginase 2	Homo sapiens	144-148
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	85-95	arginase 2	Homo sapiens	49-53
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	85-95	arginase 2	Homo sapiens	218-222
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 2	Homo sapiens	49-53
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 2	Homo sapiens	49-53
33232463-9	2021	CONCLUSIONS: Genetic variability in the ARG1 and ARG2 genes is associated with blood l-arginine concentrations in humans: ARG1 is associated with blood l-arginine concentrations in l-arginine supplement users, whereas ARG2 is associated with blood l-arginine concentrations in unsupplemented participants.	Arginine	152-162	arginase 2	Homo sapiens	49-53
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	103-113	arginase 2	Homo sapiens	83-87
33232463-10	2021	Our study is the first to describe a possible functional relation between ARG1 and ARG2 SNPs and blood l-arginine concentrations; genetic variability in ARG1 may explain variation in blood l-arginine concentrations during supplement use and discrepant study results.	Arginine	189-199	arginase 2	Homo sapiens	83-87
33782401-4	2021	We find that PRMT7 predominantly methylates a glycine and arginine motif; multiple PRMT7-regulated arginine methylation sites are close to phosphorylations sites; methylation sites and proximal sequences are vulnerable to cancer mutations; and methylation is enriched in proteins associated with spliceosome and RNA-related pathways.	Arginine	58-66	protein arginine methyltransferase 7	Homo sapiens	13-18
33782401-4	2021	We find that PRMT7 predominantly methylates a glycine and arginine motif; multiple PRMT7-regulated arginine methylation sites are close to phosphorylations sites; methylation sites and proximal sequences are vulnerable to cancer mutations; and methylation is enriched in proteins associated with spliceosome and RNA-related pathways.	Arginine	99-107	protein arginine methyltransferase 7	Homo sapiens	83-88
33782401-5	2021	We show that PRMT4/5/7-mediated arginine methylation regulates hnRNPA1 binding to RNA and several alternative splicing events.	Arginine	32-40	coactivator associated arginine methyltransferase 1	Homo sapiens	13-22
33782401-6	2021	In breast, colorectal and prostate cancer cells, PRMT4/5/7 are upregulated and associated with high levels of hnRNPA1 arginine methylation and aberrant alternative splicing.	Arginine	118-126	coactivator associated arginine methyltransferase 1	Homo sapiens	49-58
32795323-12	2020	Finally, the mRNA expression of IRAK1/TRAF6 in microglia and GPx1/bcl-xL in neurons was reversed by the ALX/FPR2-specific antagonist Trp-Arg-Trp-Trp-Trp-Trp-NH2 (WRW4), indicating that ALX/FPR2 could mediate the neuroprotective effects of RvD1.	Arginine	137-140	glutathione peroxidase 1	Homo sapiens	61-65
34740654-5	2022	The abundance of ARGs ranged from 1.05 x 10-1 to 2.93 x 10-1 copy of ARG per copy of 16S rRNA gene in all the sediment samples and the profiles of ARGs presented similar patterns in two estuaries.	Arginine	69-72	serpin family A member 2 (gene/pseudogene)	Homo sapiens	17-21
34686989-11	2022	Furthermore, our findings proposed that elevated vulnerability of Vitiligo patients due to DRB4*01:01 and DRB1*07:01 alleles maybe is correlated with the presence of amino acid Arginine at position 71 at pocket 4 on the antigen-binding site of the HLA-DRB1 receptor.	Arginine	177-185	major histocompatibility complex, class II, DR beta 4	Homo sapiens	91-95
34971693-4	2022	By using positron emission tomography (PET) imaging, we measured the intrapulmonary pharmacokinetics of the model P-gp substrates (R)-(11C)verapamil ((11C)VPM) and (11C)-N-desmethyl-loperamide ((11C)dLOP) administered by intratracheal aerosolization in three rat groups: wild-type, Abcb1a/b(-/-) and wild-type treated with the P-gp inhibitor tariquidar.	Arginine	130-134	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	114-118
34992539-9	2021	We also show that the naturally occurring arginine in NaV1.3 (NaV1.3-R1560), which corresponds to NaV1.7-W1538R, is not sufficient to explain the resistance of NaV1.3 to clinically-relevant concentrations of lacosamide.	Arginine	42-50	sodium voltage-gated channel alpha subunit 9	Homo sapiens	98-104
34893540-4	2021	Proteins bearing the R-CO2 N-degron are targeted via Lys48 (K48)-linked ubiquitylation by UBR1/UBR2 N-recognins for proteasomal degradation.	Arginine	21-22	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	90-94
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Arginine	26-29	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	58-62
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Arginine	26-29	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	107-111
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Arginine	26-29	3-ketoacyl-CoA synthase 9	Arabidopsis thaliana	144-148
34894237-5	2021	4) Asp (308 aa) and three Arg (309 to 311 aa) residues of KCS9 were essential for the homo-interactions of KCS9 and hetero-interactions between KCS9 and PAS2 or ECR.	Arginine	26-29	Protein-tyrosine phosphatase-like, PTPLA	Arabidopsis thaliana	153-157
34888656-7	2022	Using a combination of in vitro methylation and cell-based experiments we identified PRMT4 (CARM1) and PRMT6 as major enzymes methylating HTT at specific arginines.	Arginine	154-163	coactivator associated arginine methyltransferase 1	Homo sapiens	85-90
34888656-7	2022	Using a combination of in vitro methylation and cell-based experiments we identified PRMT4 (CARM1) and PRMT6 as major enzymes methylating HTT at specific arginines.	Arginine	154-163	coactivator associated arginine methyltransferase 1	Homo sapiens	92-97
34943060-0	2021	l-Arginine Alleviates LPS-Induced Oxidative Stress and Apoptosis via Activating SIRT1-AKT-Nrf2 and SIRT1-FOXO3a Signaling Pathways in C2C12 Myotube Cells.	Arginine	0-10	forkhead box O3	Mus musculus	105-111
34943060-6	2021	Furthermore, l-Arg improved antioxidant-related enzymes" activities; increased antioxidant ability via Akt-Nrf2 signaling pathway; maintained the mitochondrial membrane potential (MMP); and enhanced FOXO3a expression, leading to a decrease in the mitochondrial-associated apoptotic proteins.	Arginine	13-18	forkhead box O3	Mus musculus	199-205
34637963-0	2021	Role of active site arginine residues in substrate recognition by PPM1A.	Arginine	20-28	protein phosphatase, Mg2+/Mn2+ dependent 1A	Homo sapiens	66-71
34865122-3	2021	Arginine-methylation of BAF155 by coactivator-associated arginine methyltransferase 1 (CARM1) promotes triple-negative breast cancer (TNBC) metastasis.	Arginine	0-8	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	24-30
34865122-3	2021	Arginine-methylation of BAF155 by coactivator-associated arginine methyltransferase 1 (CARM1) promotes triple-negative breast cancer (TNBC) metastasis.	Arginine	0-8	coactivator associated arginine methyltransferase 1	Homo sapiens	34-85
34865122-3	2021	Arginine-methylation of BAF155 by coactivator-associated arginine methyltransferase 1 (CARM1) promotes triple-negative breast cancer (TNBC) metastasis.	Arginine	0-8	coactivator associated arginine methyltransferase 1	Homo sapiens	87-92
34865122-8	2021	These findings illustrate a unique mechanism of arginine methylation of a SWI/SNF subunit that drives epigenetic dysregulation, and establishes me-BAF155 as a therapeutic target to enhance immunotherapy efficacy.	Arginine	48-56	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	Homo sapiens	147-153
34767799-9	2021	A specific arginine-to-lysine change in the highest affinity cyclic peptide reduced TAR binding by 10-fold, suggesting that TBP-derived cyclic peptides use an arginine-fork motif to recognize the TAR major-groove while differentiating the mode of binding from other TAR-targeting molecules.	Arginine	11-19	TATA-box binding protein	Homo sapiens	124-127
34767799-9	2021	A specific arginine-to-lysine change in the highest affinity cyclic peptide reduced TAR binding by 10-fold, suggesting that TBP-derived cyclic peptides use an arginine-fork motif to recognize the TAR major-groove while differentiating the mode of binding from other TAR-targeting molecules.	Arginine	159-167	TATA-box binding protein	Homo sapiens	124-127
34901821-0	2021	HIF-1alpha overexpression in mesenchymal stem cell-derived exosome-encapsulated arginine-glycine-aspartate (RGD) hydrogels boost therapeutic efficacy of cardiac repair after myocardial infarction.	Arginine	80-88	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	0-10
34805153-4	2021	Among them, a single mutation on the retinol saturase gene (RETSAT) containing amino acid switch from glutamine (Q) to arginine (R) at the position 247 was identified.	Arginine	119-127	retinol saturase (all trans retinol 13,14 reductase)	Mus musculus	37-58
34757813-1	2021	It is hypothesized that L-arginine (ARG) can improve etoposide (VP-16) water solubility while preserving its anticancer activity.	Arginine	24-34	host cell factor C1	Homo sapiens	64-69
34757813-1	2021	It is hypothesized that L-arginine (ARG) can improve etoposide (VP-16) water solubility while preserving its anticancer activity.	Arginine	36-39	host cell factor C1	Homo sapiens	64-69
34757813-7	2021	The interaction between VP-16 and ARG transforms the drug from crystalline to amorphous solid state.	Arginine	34-37	host cell factor C1	Homo sapiens	24-29
34757813-9	2021	However, at higher drug concentrations (500 muM) the complex"s higher anticancer activity is ascribed to the synergistic effect between ARG and VP-16.	Arginine	136-139	host cell factor C1	Homo sapiens	144-149
34476645-2	2021	Reparixin (R), an investigational oral inhibitor of CXCR1, was safely administered to metastatic breast cancer patients in combination with paclitaxel (P) and appeared to reduce CSC in a window-of-opportunity trial in operable breast cancer.	Arginine	11-12	C-X-C motif chemokine receptor 1	Homo sapiens	52-57
34688657-3	2021	Some forms of inherited intellectual disability (ID) have been associated with a serine-to-leucine substitution in the SRM (S132L mutation) and a glycine-to-arginine substitution outside the SRM (G243R mutation) in CERT; however, it is unclear if mutations outside the SRM disrupt the control of CERT functionality.	Arginine	157-165	ceramide transporter 1	Homo sapiens	215-219
34583098-10	2021	Arginine methylation of TLR4 on R812 or PRMT2 enhanced interferon-beta (IFN-beta) production.	Arginine	0-8	protein arginine methyltransferase 2	Homo sapiens	40-45
34900242-6	2021	The best interacting sites of galactomannan included ASN-437, SER 373, TRP-436, ASN-343, and ALA 344 with a mean binding energy of -7.4 kcal/mol; and the best interacting sites of betulinic acid were ASN-437, SER 373, TRP-436, PHE 342, ARG 509, and ALA 344 that strongly interacted with the S-protein (DeltaG = -8.1 kcal/mol).	Arginine	236-239	vitronectin	Homo sapiens	291-300
34524407-3	2021	We previously demonstrated that JP2 is cleaved by calpain-1 (CAPN1) between Arginine 565 (R565) and Threonine 566 (T566).	Arginine	76-84	junctophilin 2	Homo sapiens	32-35
34492270-5	2021	We sought to address this key biological question by examining how different macromolecular contexts where the core histones reside may regulate arginine methylation catalyzed by individual PRMT members (i.e., PRMT1, -3, -4, -5, -6, -7, and -8).	Arginine	145-153	protein arginine methyltransferase 1	Homo sapiens	210-243
34685533-0	2021	Arginine Regulates TOR Signaling Pathway through SLC38A9 in Abalone Haliotis discus hannai.	Arginine	0-8	solute carrier family 38 member 9	Homo sapiens	49-56
34416110-4	2021	Cathepsin B displayed preferences for cleaving peptides with Arg in the P2 position at pH 7.2 and Glu in the P2 position at pH 4.6, represented by its primary dipeptidyl carboxypeptidase and modest endopeptidase activity.	Arginine	61-64	cathepsin B	Homo sapiens	0-11
34497269-7	2021	Thus, our results reveal a novel epigenetic mechanism through which PRMT7-mediated histone arginine monomethylation activates Foxm1 transcriptional expression to regulate AMYFs proliferation and differentiation during lung alveologenesis and may represent a potential target for intervention in pulmonary diseases.	Arginine	91-99	forkhead box M1	Mus musculus	126-131
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Arginine	73-76	C-X-C motif chemokine receptor 4	Homo sapiens	25-30
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Arginine	73-76	C-X-C motif chemokine receptor 4	Homo sapiens	159-164
34424706-9	2021	Molecular docking of the CXCR4/NOTA-CP01 complex suggested that the Lys, Arg, and NOTA of this ligand have a strong polar interaction with the key residues of CXCR4, which explains the tight affinity of (64Cu)NOTA-CP01 for CXCR4.	Arginine	73-76	C-X-C motif chemokine receptor 4	Homo sapiens	223-228
34197778-0	2021	Targeting HMGB1/TLR4/NF-kappaB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats.	Arginine	89-99	high mobility group box 1	Rattus norvegicus	10-15
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	high mobility group box 1	Rattus norvegicus	81-114
34197778-8	2021	Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression.	Arginine	38-48	high mobility group box 1	Rattus norvegicus	116-121
34466676-4	2021	Specifically, arginine can regulate energy homeostasis via modulating the adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) pathway, and also regulate protein synthesis via activating the target of rapamycin (TOR) signaling pathway.	Arginine	14-22	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	133-137
34187836-1	2021	Transmembrane 4 L six family member 5 (TM4SF5) functions as a sensor for lysosomal arginine levels and activates the mammalian target of rapamycin complex 1 (mTORC1).	Arginine	83-91	transmembrane 4 L six family member 5	Homo sapiens	0-37
34187836-1	2021	Transmembrane 4 L six family member 5 (TM4SF5) functions as a sensor for lysosomal arginine levels and activates the mammalian target of rapamycin complex 1 (mTORC1).	Arginine	83-91	transmembrane 4 L six family member 5	Homo sapiens	39-45
34309156-7	2021	ARGs were observed for every class of antibiotic except for carbapenems in APM, suggesting high ARG prevalence in APM, and APM functions in transmission of antimicrobial resistance.	Arginine	96-99	serpin family A member 2 (gene/pseudogene)	Homo sapiens	0-4
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	Xbp1p	Saccharomyces cerevisiae S288C	191-195
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	GTPase-activating protein BUD2	Saccharomyces cerevisiae S288C	217-221
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	Spc42p	Saccharomyces cerevisiae S288C	253-258
34502421-6	2021	Here we report a discovery of a G1 cyclin-specific (Cln1,2) lysine-arginine-rich helical docking motif (the K/R motif) in G1-CDK targets involved in the mating pathway (Ste7), transcription (Xbp1), bud morphogenesis (Bud2) and spindle pole body (Spc29, Spc42, Spc110, Sli15) function of S. cerevisiae.	Arginine	67-75	Sli15p	Saccharomyces cerevisiae S288C	268-273
34453010-0	2021	Picking the arginine lock on PQLC2 cycling.	Arginine	12-20	solute carrier family 66 member 1	Homo sapiens	29-34
34443627-6	2021	Next, the double substitution of OYE3 led to the unique variant S296F/W116G, which exhibited strict (R)-enantioselectivity in the reduction of (E)-citral and (E/Z)-citral, but was not active on (Z)-citral.	Arginine	101-102	NADPH dehydrogenase	Saccharomyces cerevisiae S288C	33-37
34344826-0	2021	Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism.	Arginine	0-8	solute carrier family 66 member 1	Homo sapiens	59-64
34344826-8	2021	Surprisingly, the specific presence of arginine, but not other substrates (lysine, histidine), in the discharge ("trans") compartment impaired PQLC2 transport.	Arginine	39-47	solute carrier family 66 member 1	Homo sapiens	143-148
34344826-10	2021	Arginine binding may thus tune PQLC2 gating to control its conformation, suggesting a potential mechanism for nutrient signaling by PQLC2 to its interaction partners.	Arginine	0-8	solute carrier family 66 member 1	Homo sapiens	31-36
34344826-10	2021	Arginine binding may thus tune PQLC2 gating to control its conformation, suggesting a potential mechanism for nutrient signaling by PQLC2 to its interaction partners.	Arginine	0-8	solute carrier family 66 member 1	Homo sapiens	132-137
34080028-5	2021	In addition, ANRIL overexpression reduced lactate dehydrogenase release and apoptosis of H9c2 cardiomyocytes exposed to H/R, indicating that ANRIL prevented H/R-induced cardiomyocyte injury.	Arginine	122-123	CDKN2B antisense RNA 1	Homo sapiens	13-18
34080028-5	2021	In addition, ANRIL overexpression reduced lactate dehydrogenase release and apoptosis of H9c2 cardiomyocytes exposed to H/R, indicating that ANRIL prevented H/R-induced cardiomyocyte injury.	Arginine	122-123	CDKN2B antisense RNA 1	Homo sapiens	141-146
34080028-5	2021	In addition, ANRIL overexpression reduced lactate dehydrogenase release and apoptosis of H9c2 cardiomyocytes exposed to H/R, indicating that ANRIL prevented H/R-induced cardiomyocyte injury.	Arginine	159-160	CDKN2B antisense RNA 1	Homo sapiens	141-146
34440512-3	2021	PRMT7 is a unique, evolutionarily conserved PRMT family member that catalyzes the mono-methylation of arginine.	Arginine	102-110	protein arginine methyltransferase 7	Homo sapiens	0-5
34440512-9	2021	Thus, PRMT7 is an important cellular regulator of arginine methylation in health and disease.	Arginine	50-58	protein arginine methyltransferase 7	Homo sapiens	6-11
34120493-9	2022	The +FD animals expressed significantly reduced levels of eNOS(pS1177) than sham-operated controls (P = 0.0335), while both the +FD and +FD/+Arg groups had reduced levels of eNOS(pT495) relative to sham-operated controls (P = 0.0331 and P = 0.0311, respectively).	Arginine	141-144	nitric oxide synthase, endothelial	Oryctolagus cuniculus	174-178
34095122-7	2021	Arginine transporter CAT-1 and Human member 14 of the solute carrier family 6 (SLC6A14) are overexpressed in colorectal cancer cells and contributes to intracellular arginine levels.	Arginine	166-174	solute carrier family 7 member 1	Homo sapiens	21-26
34095122-7	2021	Arginine transporter CAT-1 and Human member 14 of the solute carrier family 6 (SLC6A14) are overexpressed in colorectal cancer cells and contributes to intracellular arginine levels.	Arginine	166-174	solute carrier family 6 member 14	Homo sapiens	79-86
34095122-8	2021	Human member 9 of the solute carrier family 38 (SLC38A9) serves as a component of the lysosomal arginine-sensing machinery.	Arginine	96-104	solute carrier family 38 member 9	Homo sapiens	48-55
34123401-5	2021	In a posthoc analysis of a randomized, placebo-controlled human clinical trial of L-arginine supplementation in people with asthma and predominantly with obesity, the results showed that 12 weeks of continuous L-arginine supplementation significantly decreased the level of IL-21 (p = 0.02) and increased the level of insulin (p = 0.02).	Arginine	82-92	interleukin 21	Homo sapiens	274-279
34123401-5	2021	In a posthoc analysis of a randomized, placebo-controlled human clinical trial of L-arginine supplementation in people with asthma and predominantly with obesity, the results showed that 12 weeks of continuous L-arginine supplementation significantly decreased the level of IL-21 (p = 0.02) and increased the level of insulin (p = 0.02).	Arginine	210-220	interleukin 21	Homo sapiens	274-279
34251635-5	2021	Cells have intracellular amino acid sensors, for example, Sestrin2 for leucine and CASTOR2 for arginine, that respond to sufficiency or deficiency in amino acids, thereby inhibiting or activating downstream signals for gene expression, respectively.	Arginine	95-103	cytosolic arginine sensor for mTORC1 subunit 2	Homo sapiens	83-90
34151836-9	2021	CONCLUSION: Patients with HNSCC not only have an increased level of 8-oxoguanine and the Arg399Gln and Arg/Trp of XRCC1 modulate risk of cancer, but there is also a relationship between these two phenomena, and it can be explained using intragenic combinations revealing that a high level of 8-oxoG could be a potential mechanism behind the modulation of HNSCC risk by the polymorphisms studied.	Arginine	103-106	X-ray repair cross complementing 1	Homo sapiens	114-119
35598662-5	2022	Using feeds with different ARGs abundances revealed that higher ARG abundance in the feed resulted in higher ARG abundance in the filtrate.	Arginine	64-67	serpin family A member 2 (gene/pseudogene)	Homo sapiens	27-31
35598662-5	2022	Using feeds with different ARGs abundances revealed that higher ARG abundance in the feed resulted in higher ARG abundance in the filtrate.	Arginine	109-112	serpin family A member 2 (gene/pseudogene)	Homo sapiens	27-31
35452957-5	2022	The region of p62 where NEDD4 binds is located at the proline- and arginine (PR)-rich region (amino acids: 102-119), C-terminal extension of the Phox and Bem1 (PB1) domain.	Arginine	67-75	sequestosome 1	Homo sapiens	14-17
35616638-8	2022	Sequential ligation of l-arginine and l-valine was afforded by two GCN5-related N-acetyltransferases in a tRNA-dependent manner.	Arginine	23-33	lysine acetyltransferase 2A	Homo sapiens	67-71
35608718-8	2022	Moreover, overexpressed PLCbeta1 was mainly enriched in the transforming growth factor-beta signaling pathway, while the knockdown of miR-1297 was focused on the arginine biosynthesis pathway.	Arginine	162-170	microRNA 1297	Homo sapiens	134-142
35613513-8	2022	At the molecular level, less interaction of proinsulin with UGGT1 was observed in both human UGGT1R1526C and mouse UGGT1L1518C with/without arginine.	Arginine	140-148	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	115-120
35613513-9	2022	However, UGGT1R1526C and UGGT1WT interact with arginine similarly.	Arginine	47-55	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	9-14
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	27-35	interleukin 6	Gallus gallus	187-191
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	73-81	interleukin 6	Gallus gallus	187-191
35590365-8	2022	After treatment with 1.92% arginine level diet to broilers or 300 mug/mL arginine culture medium to LMH cell line with FAdV-4 infection at the same time, we found that the mRNA levels of IL-6, IL-1beta, IFN-alpha and the protein levels of p-JAK2, p-STAT3 were down-regulated, compared with FAdV-4 infection group.	Arginine	73-81	interferon	Gallus gallus	203-212
35579101-5	2022	After instillation, the presence of integrin-beta1 endows coated nanoparticles with steady adhesion via specific binding to Arg-Gly-Asp sequence on the fibronectin of ocular epithelium, achieving durable retention on ocular surface.	Arginine	124-127	integrin subunit beta 1	Homo sapiens	36-50
35210358-5	2022	We show that the PB1 domain and adjacent linker region of p62 (aa 1-122) are necessary and sufficient for specific vault RNA1-1 binding, and identify lysine 7 and arginine 21 as key hinges for p62 riboregulation.	Arginine	163-171	nucleoporin 62	Homo sapiens	58-61
35210358-5	2022	We show that the PB1 domain and adjacent linker region of p62 (aa 1-122) are necessary and sufficient for specific vault RNA1-1 binding, and identify lysine 7 and arginine 21 as key hinges for p62 riboregulation.	Arginine	163-171	nucleoporin 62	Homo sapiens	193-196
35565298-3	2022	The genetic deletion of PRMT7 by CRISPR-Cas9 reduced the colony formation of T-ALL cells and changed arginine monomethylation patterns in protein complexes associated with the RNA and DNA processing and the T-ALL pathogenesis.	Arginine	101-109	protein arginine methyltransferase 7	Homo sapiens	24-29
35563766-9	2022	Cumulatively, our results demonstrate that YTHDC1 binding to SRSF3 is regulated by not only hypo-phosphorylated residues of arginine/serine-rich (RS) domain of SRSF3 but also other parts of SRSF3 via YTHDC1 N- or C-terminal residues.	Arginine	124-132	serine and arginine rich splicing factor 3	Homo sapiens	61-66
35563766-9	2022	Cumulatively, our results demonstrate that YTHDC1 binding to SRSF3 is regulated by not only hypo-phosphorylated residues of arginine/serine-rich (RS) domain of SRSF3 but also other parts of SRSF3 via YTHDC1 N- or C-terminal residues.	Arginine	124-132	serine and arginine rich splicing factor 3	Homo sapiens	160-165
35566069-6	2022	The longer distance between the anomeric C1" carbon of the ribose ring in OAADPr and Arg274 of SIRT1 (a conserved residue among sirtuins) than that between the anomeric C1" carbon in OAADPr and the Arg of SIRT2, SIRT3, SIRT5, and SIRT6, should be responsible for the high selectivity of CWR for SIRT1.	Arginine	198-201	sirtuin 1	Homo sapiens	95-100
35377022-0	2022	Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives.	Arginine	85-95	solute carrier family 7 member 1	Homo sapiens	58-62
35377022-0	2022	Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives.	Arginine	100-108	solute carrier family 7 member 1	Homo sapiens	58-62
35377022-1	2022	The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of L-arginine and some of its derivatives.	Arginine	105-115	solute carrier family 7 member 1	Homo sapiens	39-43
35377022-1	2022	The cationic amino acid transporter 1 (CAT1/SLC7A1) plays a key role in the cellular uptake or export of L-arginine and some of its derivatives.	Arginine	105-115	solute carrier family 7 member 1	Homo sapiens	44-50
35377022-2	2022	This study investigated the effect of 113 chemically diverse and commonly used drugs (at 20 and 200 microM) on the CAT1-mediated cellular uptake of L-arginine, L-homoarginine, and asymmetric dimethylarginine (ADMA).	Arginine	148-158	solute carrier family 7 member 1	Homo sapiens	115-119
35286077-1	2022	In an effort to develop precursors for the production of lanthanide silicate (LnSiOx) materials, the reactions of (Ln(NR2)3) (R = SiMe3) with three equivalents of tris(trimethylsilyl)silanol (H-OSi(SiMe3)3) or H-SST) in tetrahydrofuran (THF) were undertaken.	Arginine	126-127	somatostatin	Homo sapiens	212-215
35236296-1	2022	Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins.	Arginine	72-80	peptidyl arginine deiminase 2	Homo sapiens	0-35
35236296-1	2022	Peptididylarginine deiminase type 2 (PADI2) catalyzes the conversion of arginine residues to citrulline residues on proteins.	Arginine	72-80	peptidyl arginine deiminase 2	Homo sapiens	37-42
35143176-5	2022	Biochemical analyses reveal that these molecules are the first inhibitors to target the PHD finger of UHRF1, specifically disrupting histone H3 arginine 2 interactions with the PHD finger.	Arginine	144-152	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	102-107
35137449-3	2022	UBA6-AS1 was preferentially induced in triple-negative BC (TNBC) cells deprived of arginine or glutamine, two critical amino acids required for cancer cell growth, or treated with ER stress inducers.	Arginine	83-91	ubiquitin like modifier activating enzyme 6	Homo sapiens	0-4
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	247-252
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	heat shock protein family A (Hsp70) member 8	Homo sapiens	254-259
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	heat shock protein family A (Hsp70) member 8	Homo sapiens	260-265
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	sequestosome 1	Homo sapiens	372-378
35164882-5	2022	While interactomes of arginine rich poly-GR and poly-PR aggregates overlapped and were enriched for nucleolar and ribosomal proteins, poly-GA aggregates demonstrated a distinct association with proteasomal components, molecular chaperones (HSPA1A/HSP70, HSPA8/HSC70, VCP/p97), co-chaperones (BAG3, DNAJA1A) and other factors that regulate protein folding and degradation (SQSTM1/p62, CALR, CHIP/STUB1).	Arginine	22-30	sequestosome 1	Homo sapiens	379-382
34296278-5	2022	Four members of this family, PpAAP1, PpAAP2, PpAAP3, and PpAAP4 were phylogenetically related to AtAAP5, involved in arginine transport in Arabidopsis thaliana.	Arginine	117-125	amino acid permease 5	Arabidopsis thaliana	97-103
34296278-8	2022	Furthermore, PpAAP1 was able to restore the severely affected root uptake of arginine displayed by AtAAP5 T-DNA mutants.	Arginine	77-85	amino acid permease 5	Arabidopsis thaliana	99-105
34296278-9	2022	Uptake rates of 15N-labeled arginine were significantly higher in PpAAP1-overexpressing plants when compared to wild-type and AtAAP5 mutant plants.	Arginine	28-36	amino acid permease 5	Arabidopsis thaliana	126-132
34100419-4	2022	Consistent with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4 (SRRM4) protein, the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons, RSTS iNeurons show downregulated genes for proteins impacting this network.	Arginine	75-83	E1A binding protein p300	Mus musculus	209-214
9531034-0	1998	Importance of the FcgammaRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis.	Arginine	30-33	Fc gamma receptor IIa	Homo sapiens	18-29
9531034-8	1998	When control platelet FcgammaRIIa-131 was of Arg/Arg form, only 47% of the HIT plasmas were positive by SRA, compared to 81% and 74% for His/His or His/Arg forms, respectively.	Arginine	45-48	Fc gamma receptor IIa	Homo sapiens	22-33
9531034-8	1998	When control platelet FcgammaRIIa-131 was of Arg/Arg form, only 47% of the HIT plasmas were positive by SRA, compared to 81% and 74% for His/His or His/Arg forms, respectively.	Arginine	49-52	Fc gamma receptor IIa	Homo sapiens	22-33
9531034-8	1998	When control platelet FcgammaRIIa-131 was of Arg/Arg form, only 47% of the HIT plasmas were positive by SRA, compared to 81% and 74% for His/His or His/Arg forms, respectively.	Arginine	49-52	Fc gamma receptor IIa	Homo sapiens	22-33
9531034-10	1998	The mean anti PF4/heparin antibodies level in HIT plasma was significantly lower in negative SRA than in positive tests when using control platelets from FcgammaRIIa-Arg/Arg 131 and heterozygous donors.	Arginine	166-169	platelet factor 4	Homo sapiens	14-17
9531034-10	1998	The mean anti PF4/heparin antibodies level in HIT plasma was significantly lower in negative SRA than in positive tests when using control platelets from FcgammaRIIa-Arg/Arg 131 and heterozygous donors.	Arginine	170-173	platelet factor 4	Homo sapiens	14-17
18726267-7	1998	In R22L TCS, two water molecules occupy the space left by Arg changed to Leu.	Arginine	58-61	treacle ribosome biogenesis factor 1	Homo sapiens	8-11
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	parathyroid hormone 2	Homo sapiens	94-98
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	parathyroid hormone 2	Homo sapiens	137-141
9458885-1	1998	In macrophages and many other cell types, L-arginine is used as a substrate by both nitric oxide synthase (NOS) and arginase to produce nitric oxide (NO) and urea, respectively.	Arginine	42-52	nitric oxide synthase 1, neuronal	Mus musculus	84-105
9891757-9	1998	We conclude the following: (i) under normal physiologic conditions, expression of the Cat-1 gene in the quiescent liver is negligible, probably to prevent unnecessary transport and metabolism of arginine by the hepatic arginase in the hepatocytes.	Arginine	195-203	solute carrier family 7 member 1	Rattus norvegicus	86-91
9475737-4	1998	A dominant-negative brm mutation was generated by replacing a conserved lysine in the ATP-binding site of the BRM protein with an arginine.	Arginine	130-138	brahma	Drosophila melanogaster	20-23
9475737-4	1998	A dominant-negative brm mutation was generated by replacing a conserved lysine in the ATP-binding site of the BRM protein with an arginine.	Arginine	130-138	brahma	Drosophila melanogaster	110-113
9686345-14	1998	Thus, arginase I appears to have an important role in downregulating NO synthesis in murine macrophages by decreasing the availability of arginine.	Arginine	138-146	arginase, liver	Mus musculus	6-16
9398336-1	1997	In AAC2 from Saccharomyces cerevisiae, nine additional charged residues (six positive, three negative) were neutralized by mutagenesis following the previous mutation of six arginines.	Arginine	174-183	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	3-7
9405152-8	1997	By contrast, similar tests showed that Rev binds directly via its arginine-rich NLS to the human nuclear import receptor, importin-beta.	Arginine	66-74	Rev	Human immunodeficiency virus 1	39-42
9405152-12	1997	Our findings suggest that Rev and importin-alpha bind (via an arginine-rich sequence) to a similar region on importin-beta.	Arginine	62-70	Rev	Human immunodeficiency virus 1	26-29
9398256-2	1997	CaM binding to nNOS facilitates the transfer of NADPH-derived electrons from the reductase domain to the oxygenase domain, resulting in the conversion of L-arginine to L-citrulline with the concomitant formation of a guanylate cyclase activating factor, putatively nitric oxide.	Arginine	154-164	nitric oxide synthase 1	Homo sapiens	15-19
9398256-4	1997	Since peroxynitrite is formed by the diffusion-limited reaction between the two radical species, nitric oxide and O2.-, we employed the adrenochrome assay to examine whether nNOS was capable of producing O2.- during catalytic turnover in the presence of L-arginine.	Arginine	254-264	nitric oxide synthase 1	Homo sapiens	174-178
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Arginine	25-28	thyrotropin releasing hormone	Homo sapiens	75-82
9371719-7	1997	C-Domain ACE cleaved Lys/Arg-Arg from the C-terminus of dynorphin-(1-7), a pro-TRH peptide KRQHPGKR, and two insect peptides FSPRLGKR and FSPRLGRR.	Arginine	29-32	thyrotropin releasing hormone	Homo sapiens	75-82
9371365-4	1997	Substitutions for Arg-244 have been reported in three TEM-1 mutants: IRT-1 (which corresponds to TEM-31) (Cys), IRT-2/TEM-30 (Ser), and TEM-41 (Thr).	Arginine	18-21	hypothetical protein	Escherichia coli	54-59
9360557-9	1997	This point mutation determined the substitution of a stop codon (TGA) for arginine (CGA) at amino acid position 30 at the first zinc finger of the DNA-binding domain of the VDR.	Arginine	74-82	T-box transcription factor 1	Homo sapiens	65-68
9390441-3	1997	This transporter (LHT1, lysine histidine transporter) has little affinity for arginine when measured directly in uptake experiments or indirectly with substrate competition.	Arginine	78-86	lysine histidine transporter 1	Arabidopsis thaliana	18-22
9376373-3	1997	In the presence of L-arginine, the physiological substrate, the frequencies of the Fe-Co stretching mode and the C-O stretching mode in nNOS, the brain enzyme, are detected at 503 and 1929 cm-1, respectively; whereas in iNOS, the inducible enzyme from macrophage, the modes are detected at 512 and 1906 cm-1, respectively.	Arginine	19-29	nitric oxide synthase 1	Homo sapiens	136-140
9376373-7	1997	This may be accounted for either by an arginine-CO distance that is as much as 1 A greater in nNOS than in iNOS and eNOS or by a substantial shielding of the charge on the arginine in nNOS as compared to the other isozymes.	Arginine	39-47	nitric oxide synthase 1	Homo sapiens	94-98
9376373-7	1997	This may be accounted for either by an arginine-CO distance that is as much as 1 A greater in nNOS than in iNOS and eNOS or by a substantial shielding of the charge on the arginine in nNOS as compared to the other isozymes.	Arginine	39-47	nitric oxide synthase 1	Homo sapiens	184-188
9376373-7	1997	This may be accounted for either by an arginine-CO distance that is as much as 1 A greater in nNOS than in iNOS and eNOS or by a substantial shielding of the charge on the arginine in nNOS as compared to the other isozymes.	Arginine	172-180	nitric oxide synthase 1	Homo sapiens	184-188
9307294-8	1997	The protective action of AAC-11 was abolished by mutation of leucines to arginines within the leucine zipper domain.	Arginine	73-82	apoptosis inhibitor 5	Mus musculus	25-31
21528233-7	1997	One ovarian and one gastric cancer, and six ATL samples showed two types of polymorphisms of hMSH2 (CTT to TTT resulting in Leu changing to Phe at codon 390 in exon 7 and CAG to AAG resulting in Gin to Arg at codon 419 in exon 7).	Arginine	202-205	mutS homolog 2	Homo sapiens	93-98
9358000-1	1997	Nitric oxide (NO) is synthesized from L-arginine by a family of enzymes known as the nitric oxide synthases (NOS).	Arginine	38-48	nitric oxide synthase 1	Homo sapiens	85-107
9262406-7	1997	Arg 85 of rhoGAP interacts with the P-loop of Cdc42Hs, but from biochemical data and by analogy with the G-protein subunit G(i alpha1), we propose that it adopts a different conformation during the catalytic cycle which enables it to stabilize the transition state of the GTP-hydrolysis reaction.	Arginine	0-3	cell division cycle 42	Homo sapiens	46-53
9313865-3	1997	These values are 12 and 32 times lower than the K(m) for L-arginine with nNOS and iNOS, respectively; however, 7 does not exhibit time-dependent inhibition with either.	Arginine	57-67	nitric oxide synthase 1	Homo sapiens	73-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	thrombomodulin	Oryctolagus cuniculus	250-264
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	thrombomodulin	Oryctolagus cuniculus	266-268
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	thrombomodulin	Oryctolagus cuniculus	294-296
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	thrombomodulin	Oryctolagus cuniculus	294-296
9220985-4	1997	In contrast, Arg 97 was the major residue required for TM-dependent acceleration of reactivity with antithrombin and for CS-dependent enhancement of TM affinity.	Arginine	13-16	thrombomodulin	Oryctolagus cuniculus	55-57
9220985-4	1997	In contrast, Arg 97 was the major residue required for TM-dependent acceleration of reactivity with antithrombin and for CS-dependent enhancement of TM affinity.	Arginine	13-16	thrombomodulin	Oryctolagus cuniculus	149-151
9220985-5	1997	Arg 101 and 93 were critical for TM-dependent, high-affinity protein C interaction at low Ca2+ concentrations, while Arg 97, which was critical for the other TM-dependent effects, played no detectable role in this metal dependence.	Arginine	0-3	thrombomodulin	Oryctolagus cuniculus	33-35
9214507-4	1997	This inhibitory function is increased in tumour-derived forms of Smad2 and 4 that carry a missense mutation in a conserved N domain arginine residue.	Arginine	132-140	SMAD family member 2	Homo sapiens	65-76
9214507-6	1997	Whereas mutations in the C domain disrupt the effector function of the Smad proteins, N-domain arginine mutations inhibit SMAD signalling through a gain of autoinhibitory function.	Arginine	95-103	SMAD family member 4	Homo sapiens	122-126
9237811-8	1997	Mutein Asp Arg lose affinity for IL-2R and bioactivity simultaneously.	Arginine	11-14	interleukin 2 receptor subunit alpha	Homo sapiens	33-38
9202057-5	1997	A series of peptides surrounding a plasmin cleavage site (arginine 361) near the carboxy-terminal end of vitronectin were synthesized.	Arginine	58-66	plasminogen	Homo sapiens	35-42
9200463-7	1997	Internal deletion of the GFFKR motif, or point mutations of the Gly (G), the two Phe (F), or the Arg (R) in the GFFKR motif to Ala (A) rendered LFA-1 constitutively active.	Arginine	97-100	integrin subunit alpha L	Homo sapiens	144-149
9202292-2	1997	In one case, the editing changes a gene-encoded glutamine (Q) to an arginine (R) codon located in the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR-B and also the kainate receptor subunits GluR5 and GluR6.	Arginine	68-76	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	209-215
9202292-3	1997	Another case of RNA editing alters an arginine (R) to a glycine (G) codon at a position termed the "R/G" site of AMPA subunits GluR-B, C, and D. Double-stranded RNA-specific adenosine deaminases (DRADA) have been implicated as agents involved in the editing.	Arginine	38-46	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	127-133
9253802-0	1997	Effect of L-arginine on in vitro plasmin-generation and fibrinogenolysis.	Arginine	10-20	plasminogen	Homo sapiens	33-40
9253802-3	1997	The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis.	Arginine	61-71	plasminogen	Homo sapiens	84-91
9253802-3	1997	The aim of the present paper is to investigate the action of L-arginine on in vitro plasmin generation and fibrino(geno)lysis by chromogenic, kinetic plasmin generation assay and electrophoretic analysis.	Arginine	61-71	plasminogen	Homo sapiens	150-157
9253802-4	1997	The acceleration of tPA-induced plasmin generation in the presence of low concentration of L-arginine, along with augmentation of in vitro fibrinogenolysis have been documented.	Arginine	91-101	plasminogen	Homo sapiens	32-39
9184143-0	1997	Phosphatidylinositol-specific phospholipase C: kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol.	Arginine	110-118	phospholipase C beta 1	Homo sapiens	0-45
9357156-4	1997	The advent of molecular biology techniques has enabled isolation of cDNA for the inhibitors PAI-1, PAI-2 and PAI-3 and data indicate that these belong to the serine protease inhibitor (Serpine) family with arginine as its active site but immunologically distinct from each other.	Arginine	206-214	serpin family A member 5	Homo sapiens	109-114
9176311-7	1997	Suffusion of L-Arg (1.0 mM) partially restored impaired ACh- and CGRP-induced responses in myocardial-infarcted animals toward that observed in controls.	Arginine	13-18	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
9173872-1	1997	Nitric oxide synthase (EC 1.14.13.39) catalyses the conversion of arginine, NADPH and oxygen to nitric oxide and citrulline, using haem, (6R)-5,6,7,8-tetrahydro-l-biopterin (tetrahydrobiopterin), calmodulin, FAD and FMN as cofactors.	Arginine	66-74	calmodulin 1	Rattus norvegicus	196-206
9173879-2	1997	Further characterization of this reaction with cells expressing an arginine-specific, glycosylphosphatidylinositol-anchored, mono-ADP-ribosyltransferase demonstrated that FGF-2 is ADP-ribosylated on arginine.	Arginine	67-75	ADP-ribosyltransferase 3 (inactive)	Homo sapiens	125-152
9173879-2	1997	Further characterization of this reaction with cells expressing an arginine-specific, glycosylphosphatidylinositol-anchored, mono-ADP-ribosyltransferase demonstrated that FGF-2 is ADP-ribosylated on arginine.	Arginine	199-207	ADP-ribosyltransferase 3 (inactive)	Homo sapiens	125-152
9112018-1	1997	We report a homozygous missense mutation at position 1092 (substitution of glutamine for arginine) in the tyrosine kinase domain of the insulin receptor in a patient with leprechaunism associated with severe insulin resistance and intrauterine growth retardation.	Arginine	89-97	insulin receptor	Homo sapiens	136-152
9098069-4	1997	Downstream from the arg cluster, two open reading frames (ORF7 and ORF8) having unknown functions were found.	Arginine	20-23	hypothetical protein	Lactobacillus plantarum	58-62
9163534-1	1997	The phosphorylation site(s) involved in the activation of CaM-kinase IV by CaM-kinase kinase alpha was studied using a mutant CaM-kinase IV (K71R) in which Lys71 (ATP-binding site) was replaced with Arg, because the autophosphorylation of CaM-kinase IV occurring at multiple sites made it difficult to study phosphorylation of the enzyme by CaM-kinase kinase.	Arginine	199-202	calcium/calmodulin dependent protein kinase IV	Homo sapiens	58-71
9108251-8	1997	Among the purine PRT in our possession, only schistosomal HGPRT, the only other enzyme that contains an arginine residue at the corresponding location (Arg187), was susceptible to phenylglyoxal and butane-2,3-dione.	Arginine	104-112	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	58-63
9075646-8	1997	Substitutions of arginine 12 and arginine 14 with alanine or glutamine dramatically decrease the potency of XIP, suggesting that these residues play a key role in possible charge-charge interactions.	Arginine	17-25	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	108-111
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Arginine	160-168	interferon alpha 2	Homo sapiens	141-151
9085937-2	1997	Thus, the mature IFN-alpha2a protein product is characterized by a lysine residue at position 23 (AAA) and a histidine at position 34 (CAA), IFN-alpha2b has an arginine at position 23 (AGA) and histidine at position 34 (CAT), and IFN-alpha2c has arginine residues at both positions 23 (AGA) and 34 (CGT).	Arginine	246-254	interferon alpha 2	Homo sapiens	17-27
9078247-0	1997	Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3 alpha-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis.	Arginine	47-50	aldo-keto reductase family 1 member C3	Homo sapiens	71-107
9062960-2	1997	In almost all cases APC resistance is due to a single point mutation in the factor V gene, (a G to A substitution at nucleotide position 1691), which predicts the synthesis of a factor V molecule (FVQ506 or FV Leiden) in which the Arg 506 in one of the APC cleavage sites is replaced by Gln (7), rendering factor Va resistant to inactivation by APC.	Arginine	231-234	APC regulator of WNT signaling pathway	Homo sapiens	20-23
8999826-3	1997	However, the roles of two conserved arginine residues (Arg-111 and Arg-131 in CRABP-I; Arg-111 and Arg-132 in CRABP-II) that interact with the carboxyl group of retinoic acid have not been evaluated.	Arginine	36-44	cellular retinoic acid binding protein 1	Homo sapiens	78-85
9193651-3	1997	While mouse Rt6 proteins were found to be strong arginine-specific transferases, but comparatively weak NADases, the opposite held true for rat RT6, for which transferase activity could only be detected in the form of arginine-specific auto-ADP-ribosylation, displayed by RT6.2 but not by RT6.1.	Arginine	49-57	ADP-ribosyltransferase 2a	Mus musculus	12-15
9061929-8	1997	The cleavage site of prophenoloxidase A1 was shown to be between Arg and Phe at positions 52 and 53.	Arginine	65-68	Prophenoloxidase 1	Drosophila melanogaster	21-40
8987761-3	1997	In addition, the firing rate in 60% of the neurons inhibited by SNP decreased in response to superfusion with the natural substrate of the NO synthase (NOS) L-arginine whereas 70% increased their frequency after application of the NOS blocker NG-monomethyl-L-arginine (L-NMMA; n = 10).	Arginine	157-167	nitric oxide synthase 1	Homo sapiens	139-150
8954982-4	1996	Partial digestion with trypsin at a low concentration for less than one hour preferentially hydrolyzes Lys-Arg-Arg in position 141-143 of the SSAT suggesting that the Ser-phosphorylated residues are located in the C-terminus of the protein, probably Ser 146 and 149.	Arginine	107-110	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	142-146
8955157-12	1996	The results indicate that Arg-98 in the ATPase consensus sequence of CBATP and the corresponding residue of CEA are essential for the aggregating properties of these molecules.	Arginine	26-29	carcinoembryonic antigen gene family 4	Rattus norvegicus	108-111
8955157-13	1996	Moreover Arg-98 is essential for CBATP to interact with itself, CEA to interact with itself, and CBATP to interact with CEA.	Arginine	9-12	carcinoembryonic antigen gene family 4	Rattus norvegicus	64-67
8955157-13	1996	Moreover Arg-98 is essential for CBATP to interact with itself, CEA to interact with itself, and CBATP to interact with CEA.	Arginine	9-12	carcinoembryonic antigen gene family 4	Rattus norvegicus	120-123
8954935-7	1996	On the basis of these observations, we conclude that hCG activates expression of iNOS mRNA in mouse peritoneal macrophages accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium.	Arginine	179-189	chorionic gonadotropin subunit beta 5	Homo sapiens	53-56
8997496-3	1996	Amino acid sequence analysis of the truncated cystatin S polypeptide revealed that cystatin S was cleaved after Arg-8.	Arginine	112-115	cystatin S	Homo sapiens	83-93
8960098-1	1996	A polymorphism of the gene for Fc gamma RIIA, arginine (R) or histidine (H) at position 131, alters the ability of the receptor to bind certain IgG subclasses.	Arginine	46-54	Fc gamma receptor IIa	Homo sapiens	31-44
8936471-0	1996	Hb Nunobiki or alpha 2 141 (HC3)Arg-->Cys beta 2 in a Belgian female results from a CGT-->TGT mutation in the alpha 2-globin gene.	Arginine	32-35	hemoglobin subunit alpha 2	Homo sapiens	110-124
9007588-5	1996	All of the six patients developed one or more of the HIV-1 pol mutations known to confer resistance to ZDV in vitro (Met41--&gt;Leu, Asp67--&gt;Asn, Lys70--&gt;Arg, Thr215--&gt;Phe/Tyr, Lys219--&gt;Gln/Glu).	Arginine	160-163	endogenous retrovirus group W member 4	Homo sapiens	59-62
8923846-6	1996	The prestimulation insulin secretion rate and maximal insulin secretion rate in response to hyperglycemia and arginine were significantly lower in SPx than in WPx, Kx, or Ns (P &lt; 0.05).	Arginine	110-118	spexin hormone	Homo sapiens	147-150
8923846-7	1996	The incremental amount of insulin secreted in response to arginine was reduced by 40-70% in SPx depending on glycemia compared to that in all other groups (P &lt; 0.05), among which there were no statistical differences.	Arginine	58-66	spexin hormone	Homo sapiens	92-95
8810344-3	1996	Analysis of hemophilia A patient DNA samples have identified missense mutations within this carboxyl terminus of the FVIII light chain at amino acid 2307 in which arginine is replaced with either glutamine or leucine.	Arginine	163-171	coagulation factor VIII	Homo sapiens	117-122
8798720-0	1996	SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.	Arginine	83-91	SRSF protein kinase 1	Homo sapiens	0-5
8798720-0	1996	SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.	Arginine	83-91	CDC like kinase 1	Homo sapiens	10-17
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Arginine	48-51	CDC like kinase 1	Homo sapiens	14-17
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Arginine	126-129	CDC like kinase 1	Homo sapiens	14-17
8798720-6	1996	In vitro, the Clk/Sty kinase phosphorylated Ser-Arg, Ser-Lys, or Ser-Pro sites, whereas SRPK1 had a strong preference for Ser-Arg sites.	Arginine	126-129	SRSF protein kinase 1	Homo sapiens	88-93
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Arginine	196-204	isocitrate lyase 1	Saccharomyces cerevisiae S288C	36-40
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Arginine	196-204	isocitrate lyase 1	Saccharomyces cerevisiae S288C	173-177
8784223-7	1996	Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [15O] H2O PET technique (p &lt; 0.001 for all subjects; overall regression equation, y = 15.14 + 0.54x) and those measured by the [123I]IMP-microsphere method (p &lt; 0.001 for all subjects: y = 2.0 + 0.80x).	Arginine	5-8	CCAAT/enhancer binding protein zeta	Rattus norvegicus	34-38
8784223-12	1996	Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings.	Arginine	48-51	CCAAT/enhancer binding protein zeta	Rattus norvegicus	101-105
8902879-6	1996	These results demonstrate that TNF-alpha stimulates L-arginine transport in endothelial cells by selectively inducing the expression of CAT-2 mRNA.	Arginine	52-62	solute carrier family 7 member 2	Bos taurus	136-141
8902879-7	1996	The capacity of TNF-alpha to stimulate the expression of CAT-2 protein may provide an important mechanism by which increases in substrate are provided to endothelial cells during periods of elevated L-arginine metabolism.	Arginine	199-209	solute carrier family 7 member 2	Bos taurus	57-62
8840009-8	1996	The competitive NOS inhibitor, N-L-arginine-methyl ester, decreased basal C/C-DP of cortical mPSDp by 50% and blocked the increase elicited by L-arginine.	Arginine	33-43	cut-like homeobox 1	Rattus norvegicus	76-80
8679640-2	1996	The ethylation interference analyses of Spl(R565S) and Spl(K595S) mutants demonstrate that arginine at 565 position and lysine at 595 position interact with the phosphate between G(3) and G(4) and with the phosphate between G(9) and G(10) in GC-box DNA, respectively.	Arginine	91-99	sphingosine-1-phosphate lyase 1	Homo sapiens	40-43
8679640-2	1996	The ethylation interference analyses of Spl(R565S) and Spl(K595S) mutants demonstrate that arginine at 565 position and lysine at 595 position interact with the phosphate between G(3) and G(4) and with the phosphate between G(9) and G(10) in GC-box DNA, respectively.	Arginine	91-99	sphingosine-1-phosphate lyase 1	Homo sapiens	55-58
8764351-3	1996	Pretreatment of tissues with L-arginine (3 mM), but not D-arginine (10 mM), blocked the NPY-mediated changes in Isc.	Arginine	29-39	neuropeptide Y	Mus musculus	88-91
8764351-4	1996	This L-arginine effect on NPY activity was reversed by L-NMA (3 mM), and not by NG-methyl-D-arginine (10 mM).	Arginine	5-15	neuropeptide Y	Mus musculus	26-29
8764351-5	1996	The L-arginine effect on NPY activity was concentration-related with an A50 (95% CL) value of 1.6 (0.9-2.3) mM.	Arginine	4-14	neuropeptide Y	Mus musculus	25-28
8764351-10	1996	Pretreatment of tissues with L-arginine also blocked the reduction of Isc by [D-Pen2, D-Pen5]enkephalin (10-30 nM), H2N-Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 (10-30 nM) and somatostatin (0.3-1.0 microM), but had no effect on norepinephrine (0.1-0.3 microM)-induced decrease in mouse ileal Isc.	Arginine	29-39	presenilin enhancer gamma secretase subunit	Mus musculus	80-84
8764351-11	1996	These results show that [fgc]l-arginine and SNAP block NPY-mediated changes in ion transport, suggesting that nitric oxide may play a role in the regulation of NPY-mediated ion transport in the mouse ileum.	Arginine	29-39	neuropeptide Y	Mus musculus	55-58
8764351-11	1996	These results show that [fgc]l-arginine and SNAP block NPY-mediated changes in ion transport, suggesting that nitric oxide may play a role in the regulation of NPY-mediated ion transport in the mouse ileum.	Arginine	29-39	neuropeptide Y	Mus musculus	160-163
8672465-10	1996	We provide evidence for another interaction between Arg 306 of TM-7 and the terminal carboxamide of TRH.	Arginine	52-55	thyrotropin releasing hormone	Homo sapiens	100-103
8672473-6	1996	The second carboxylate group of glutathione, which is part of its Gly residue, interacts with two Arg side chains in GST A1-1.	Arginine	98-101	glutathione S-transferase alpha 1	Homo sapiens	117-125
8635238-3	1996	Treatment of BASMCs with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta) resulted in a significant increase in L-arginine transport (approximately 20%) and in the induction of NO release.	Arginine	137-147	interleukin 1 beta	Bos taurus	68-86
8635238-3	1996	Treatment of BASMCs with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta) resulted in a significant increase in L-arginine transport (approximately 20%) and in the induction of NO release.	Arginine	137-147	interleukin 1 beta	Bos taurus	88-97
8983941-9	1996	On comparison of the amino acid compositions of the isoforms with that of the identical 9 kDa gamma D-crystallin fragment, the isoforms showed relatively lower amino contents of Asp, Arg, Leu and Tyr residues suggesting modifications of these residues in the isoforms.	Arginine	183-186	crystallin gamma D	Homo sapiens	94-112
8616812-3	1996	This study demonstrates that argininosuccinate synthetase and GTP-cyclohydrolase-I, which catalyze rate-limiting steps in the synthesis of iNOS substrate (arginine) and cofactor (tetrahydrobiopterin), respectively, are coinduced with iNOS expression in two human tumor cell lines.	Arginine	155-163	GTP cyclohydrolase 1	Homo sapiens	62-82
8739149-6	1996	This increase was also associated with increased activity of peptidylarginine deiminase, the enzyme which converts arginine to citrulline in proteins, thereby providing a mechanism for generating less cationic forms of MBP.	Arginine	69-77	myelin basic protein	Mus musculus	219-222
8610462-5	1996	Substitution of the second arginine in its nuclear localization signal (P648RRRV) with aspartic acid rendered nsP2 totally cytoplasmic.	Arginine	27-35	reticulon 2	Homo sapiens	110-114
8621763-3	1996	Sequence analysis of the proband band 3 cDNA and genomic DNA showed a C --&gt; T substitution resulting in a nonsense mutation (CGA --&gt; TGA; Arg --&gt; Stop) at the position corresponding to codon 646 in human red cell band 3 cDNA.	Arginine	144-147	T-box transcription factor 1	Homo sapiens	139-142
8610170-3	1996	Several essential splicing factors from animals, such as SF2/ASF and SC-35, belong to a family of highly conserved proteins consisting of one or two RNA binding domain(s) (RRM) and a C-terminal Ser/Arg-rich (SR or RS) domain.	Arginine	198-201	serine and arginine rich splicing factor 2	Homo sapiens	69-74
9132167-1	1996	It has been shown that human growth hormone (hGH) is attacked and digested at Arg(134)-Thr(135) by thrombin and plasmin, facilitating its further degradation in the plasma and tissues.	Arginine	78-81	plasminogen	Homo sapiens	112-119
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Arginine	176-184	major histocompatibility complex, class II, DP beta 1	Homo sapiens	37-45
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Arginine	176-184	major histocompatibility complex, class II, DP beta 1	Homo sapiens	41-45
9157088-5	1996	On another hand, the analysis of the HLA-DPB1 locus showed that the DPB1 *0401 allele frequency was significantly increased in the RA patient group (n = 47) who expressed only arginine at the position 71 of the beta 1 chain (82% vs 56% in controls, p &lt; 0.008), with role of HLA-DR--DR and -DR-DP interactions in the genetic susceptibility to RA.	Arginine	176-184	major histocompatibility complex, class II, DP beta 1	Homo sapiens	37-40
8830053-1	1996	Nitric oxide (NO) is synthesized from L-arginine by three isoforms of NO synthase (NOS).	Arginine	38-48	nitric oxide synthase, brain	Oryctolagus cuniculus	70-81
8605626-4	1996	The functional epitope that primarily determines binding affinity consists of residues Gln 66, Lys 84 and Arg 89 in Raf.	Arginine	106-109	zinc fingers and homeoboxes 2	Homo sapiens	116-119
8552101-5	1996	Furthermore, a mutation in the AMT1 Cu-activated DNA binding domain which converts a single arginine, found in a conserved minor groove binding domain, to lysine markedly reduces AMT1 DNA binding affinity in vitro and results in a severe defect in the ability of C. glabrata cells to mount a protective response against Cu toxicity.	Arginine	92-100	ammonium permease MEP1	Saccharomyces cerevisiae S288C	31-35
8552101-5	1996	Furthermore, a mutation in the AMT1 Cu-activated DNA binding domain which converts a single arginine, found in a conserved minor groove binding domain, to lysine markedly reduces AMT1 DNA binding affinity in vitro and results in a severe defect in the ability of C. glabrata cells to mount a protective response against Cu toxicity.	Arginine	92-100	ammonium permease MEP1	Saccharomyces cerevisiae S288C	179-183
9005439-1	1996	A pathological variant of human phosphoglycerate kinase, phosphoglycerate kinase-Uppsala, associated with chronic nonspherocytic hemolytic anemia has been found to differ from the normal enzyme by substitution of an arginine at position 206 (corresponding to position 203 in yeast) by a proline.	Arginine	216-224	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	32-55
9005439-1	1996	A pathological variant of human phosphoglycerate kinase, phosphoglycerate kinase-Uppsala, associated with chronic nonspherocytic hemolytic anemia has been found to differ from the normal enzyme by substitution of an arginine at position 206 (corresponding to position 203 in yeast) by a proline.	Arginine	216-224	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	57-80
8565073-4	1996	In a C-terminal truncated form of Ste2p that is rapidly ubiquitinated and endocytosed in response to ligand binding, a single lysine to arginine substitution in its cytoplasmic tail eliminates both ubiquitination and internalization.	Arginine	136-144	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	34-39
8570639-6	1996	Modeling of an Ang-d(ApTpApA) complex suggested that Arg-5 forms part of the P2 site and that a 2"-phosphate might bind more tightly than a 3"-phosphate.	Arginine	53-56	angiogenin	Homo sapiens	15-18
8624397-1	1996	This in vitro study was an investigation of osteoblast functions on glass substrates modified with the bioactive peptide Arg-Gly-Asp-Ser (RGDS) in the absence and presence of recombinant human Osteogenic Protein-1 (OP-1); control substrates were plain glass, glass modified with amine groups, and glass modified with the non-adhesive peptide Arg-Asp-Gly-Ser.	Arginine	121-124	ral guanine nucleotide dissociation stimulator	Homo sapiens	138-142
8717347-3	1996	Genomic sequence analysis of the exons encoding the TM2 reveals the presence of an arginine codon at the Q/R site, suggesting that the RNA editing mechanism acting in the mammalian GluR2 does not operate at the homologous site in these two fish genes.	Arginine	83-91	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	181-186
8844764-1	1996	The peptide, Phe-Gly Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH, recently isolated from rat brain, has been suggested to be an endogenous agonist for an orphan, opioid-like receptor (ORL1).	Arginine	37-40	opioid related nociceptin receptor 1	Rattus norvegicus	199-203
8899819-2	1996	Ac-Ser.Tyr-Ser-Nle4-Glu- His-DPhe7-Arg-Trp-Gly-Lys-Pro-Val-NH2(NDP-MSH), led to the discovery of tripeptide agonists possessing prolonged bioactivity in the frog skin assay.	Arginine	35-38	norrin cystine knot growth factor NDP	Homo sapiens	63-66
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Arginine	91-99	estrogen receptor 2	Homo sapiens	193-196
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Arginine	121-129	estrogen receptor 2	Homo sapiens	193-196
8530440-5	1995	GK-deficient islets isolated from homozygotes showed defective insulin secretion in response to glucose, while they responded to other secretagogues: almost normally to arginine and to some extent to sulfonylureas.	Arginine	169-177	glucokinase	Mus musculus	0-2
8530370-7	1995	We next tested the hypothesis that a positively charged arginine residue (Arg209) within the transmembrane domain of Fc alpha R promotes association with FcR gamma chain.	Arginine	56-64	Fc epsilon receptor Ig	Homo sapiens	154-163
7493936-8	1995	The observed inhibition was additive with the arginine antagonists NG-monomethyl-L-arginine and 7-nitroindazole, indicating a distinct and independent mechanism of nNOS inhibition.	Arginine	46-54	nitric oxide synthase 1	Homo sapiens	164-168
7502080-1	1995	The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to calcium.	Arginine	4-12	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	44-50
8772237-2	1995	A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes.	Arginine	34-42	Fc gamma receptor IIa	Homo sapiens	72-85
8772237-2	1995	A polymorphism at amino acid 131 [arginine (Arg) or histidine (His)] of Fc gamma RIIa was first shown to be determinant for MoAb-IgG1 binding on monocytes.	Arginine	44-47	Fc gamma receptor IIa	Homo sapiens	72-85
8772237-3	1995	To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism.	Arginine	305-308	Fc gamma receptor IIa	Homo sapiens	100-113
8772237-3	1995	To clarify the role of this polymorphism in platelet activation by MoAb-IgG1 we (i) established the Fc gamma RIIa polymorphism at the gene level by adapting the denaturating gradient gel electrophoresis method, (ii) analyzed the binding affinity of the MoAbs to Fc gamma RIIa on platelets from homozygous Arg, homozygous His, and heterozygous Arg/His donors, and (iii) characterized the different reactivities of platelets according to the Fc gamma RIIA polymorphism.	Arginine	343-346	Fc gamma receptor IIa	Homo sapiens	100-113
8772237-6	1995	These 3 MoAbs-IgG1 bind to Fc gamma RIIa with a stronger affinity for the Arg-form of Fc gamma RIIa, a result which was confirmed with the use of diverse MoAbs directed against various antigens.	Arginine	74-77	Fc gamma receptor IIa	Homo sapiens	27-40
8772237-6	1995	These 3 MoAbs-IgG1 bind to Fc gamma RIIa with a stronger affinity for the Arg-form of Fc gamma RIIa, a result which was confirmed with the use of diverse MoAbs directed against various antigens.	Arginine	74-77	Fc gamma receptor IIa	Homo sapiens	86-99
7499343-1	1995	Furin is a membrane-associated endoprotease that catalyzes cleavage of precursor proteins at Arg-X-Lys/Arg-Arg sites.	Arginine	103-106	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
7499343-1	1995	Furin is a membrane-associated endoprotease that catalyzes cleavage of precursor proteins at Arg-X-Lys/Arg-Arg sites.	Arginine	103-106	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8524650-1	1995	Arginyl-tRNA synthetase (ArgRS) catalyses AMP- and PPi-independent deacylation of Arg-tRNAArg in the presence of cysteine.	Arginine	0-3	arginyl-tRNA synthetase 1	Homo sapiens	25-30
8616634-1	1995	Animal studies and cell culture experiments demonstrated that posttranscriptional editing of the transcript of the GluR-2 gene, resulting in substitution of an arginine for glutamine in the second transmembrane region (TM II) of the expressed protein, is associated with a reduction in Ca2+ permeability of the receptor channel.	Arginine	160-168	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	115-121
8616634-7	1995	In the normal human prefrontal cortex and striatum, the large majority of GluR-2 RNA molecules contains a CGG codon for arginine in the TMII coding region; this implies that the corresponding AMPA receptors have a low Ca2+ permeability, as previously demonstrated for the rat brain.	Arginine	120-128	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	74-80
7578224-6	1995	Sequence analysis of the peptide demonstrated that it corresponded precisely to amino-acid residues 235 to 246 in the human E1 beta sequence, with arginine residues at positions 239 and 242.	Arginine	147-155	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	124-131
7578224-7	1995	Since Arg-239 is conserved in the beta-subunit of all presently known sequences of the pyruvate dehydrogenase complex and branched-chain alpha-keto acid dehydrogenase complex, it is strongly suggested that Arg-239 in the human E1 beta sequence is at or near the active site of bovine E1.	Arginine	6-9	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	227-234
7578224-7	1995	Since Arg-239 is conserved in the beta-subunit of all presently known sequences of the pyruvate dehydrogenase complex and branched-chain alpha-keto acid dehydrogenase complex, it is strongly suggested that Arg-239 in the human E1 beta sequence is at or near the active site of bovine E1.	Arginine	206-209	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	227-234
7568075-2	1995	NO is synthesized from L-arginine by NO synthase (NOS).	Arginine	23-33	Nitric oxide synthase	Drosophila melanogaster	37-48
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Arginine	0-9	cerebellar degeneration related antigen 1	Mus musculus	107-111
7673735-7	1995	Arginines at the junction of V kappa 1 or V kappa 8 regions and J kappa 1, and arginines or asparagines in CDR1 or CDR2 enhanced DNA binding.	Arginine	0-9	cerebellar degeneration-related 2	Mus musculus	115-119
7543000-6	1995	The production of nitrogen oxides (NOx), assessed by chemiluminescence, and nitric oxide synthase activity, assessed by arginine/citrulline conversion were increased in TGF beta 1-treated cells.	Arginine	120-128	transforming growth factor beta 1	Bos taurus	169-179
7544282-1	1995	The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein.	Arginine	30-33	myelin basic protein	Homo sapiens	141-161
7544282-1	1995	The peptide AcAla-Ser-Gln-Lys-Arg-Pro-Ser-Gln-Arg-His-Gly-Ser-Lys-Tyr, which comprises the first 14 residues of the acetylated N-terminus of myelin basic protein, is an epitopic site for two monoclonal antibodies to the human protein.	Arginine	46-49	myelin basic protein	Homo sapiens	141-161
22911578-5	1995	The exchange broadening, due to N(epsilon)-C(zeta) bond flips, typically results in weak or missing signals for the eta-NH(2) protons of arginine residues in HMQC or INEPT experiments recorded at room temperature, unless the motion is restricted in some way.	Arginine	137-145	endothelin receptor type A	Homo sapiens	46-49
22911578-6	1995	In a related series of experiments, the pH dependence of the hydrogen exchange rates of the epsilon-NH and eta-NH(2) protons of arginine was measured using saturation transfer (1)H NMR spectroscopy and compared with the equivalent NH(2) protons of the guanidinium ion.	Arginine	128-136	endothelin receptor type A	Homo sapiens	107-110
7794933-12	1995	It is concluded that Arg 276 is critical for activity and Mg2+ cooperativity with FBPase and it determines the enzyme"s kinetic mechanism.	Arginine	21-24	mucin 7, secreted	Homo sapiens	58-61
7539113-2	1995	It is generated from L-arginine by the enzyme NO synthase (NOS).	Arginine	21-31	nitric oxide synthase 1, neuronal	Mus musculus	46-57
7744838-5	1995	Substitution of Arg-83 with amino acids of diverse structures including Lys, a conservative change, yielded mutant G6Pase with no enzymatic activity.	Arginine	16-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	115-121
7744838-9	1995	It is possible that Arg-83 is involved in stabilizing the enzyme (His)-phosphate intermediate formed during G6Pase catalysis.	Arginine	20-23	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	108-114
7537730-3	1995	AQP-CD contains a consensus sequence for cAMP-dependent protein kinase, residues at positions 253-256 (Arg-Arg-Gln-Ser).	Arginine	103-106	aquaporin 2 L homeolog	Xenopus laevis	0-6
7537730-3	1995	AQP-CD contains a consensus sequence for cAMP-dependent protein kinase, residues at positions 253-256 (Arg-Arg-Gln-Ser).	Arginine	107-110	aquaporin 2 L homeolog	Xenopus laevis	0-6
7771573-1	1995	L-Arginine analogues, e.g., NG-nitro-L-arginine methyl ester (L-NAME), increase arterial pressure and suppress renin release in the rat.	Arginine	0-10	renin	Rattus norvegicus	111-116
7771573-10	1995	Overall these results suggest that L-arginine analogues attenuate aldosterone secretion by inhibiting the adrenal steroidogenic effects of endogenous or exogenous angiotensin II and/or by reducing plasma levels of renin/angiotensin.	Arginine	35-45	renin	Rattus norvegicus	214-219
7641023-16	1995	Furthermore, EGF and TGF alpha preferentially stimulate L-arginine uptake via the Na(+)-dependent transporter, ostensibly to accommodate for the mitogenic stimulus.	Arginine	56-66	transforming growth factor alpha	Homo sapiens	21-30
8589271-8	1995	Additionally, the engagement of CD23 led to the activation of the L-arginine-dependent pathway of nitric oxide (NO) production, as detected by the increase in intracytoplasmic cGMP concentration.	Arginine	66-76	Fc epsilon receptor II	Homo sapiens	32-36
7733888-11	1995	These results suggest that Arg-309 of EP3 receptor may be essential in ligand binding through ionic interaction.	Arginine	27-30	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	38-41
7744054-5	1995	Kex2 preferentially cleaved PTHrP(1-141) carboxy to the triplet arginine site Arg-Arg-Arg21 with a Km of 3.3 +/- 1.7 microM and a kcat of 6 +/- 1.2 s-1.	Arginine	64-72	parathyroid hormone like hormone	Homo sapiens	28-33
7744054-5	1995	Kex2 preferentially cleaved PTHrP(1-141) carboxy to the triplet arginine site Arg-Arg-Arg21 with a Km of 3.3 +/- 1.7 microM and a kcat of 6 +/- 1.2 s-1.	Arginine	82-85	parathyroid hormone like hormone	Homo sapiens	28-33
7744054-11	1995	These studies indicate that the preferred Kex2 cleavage site in PTHrP(1-141) is carboxy to Arg-Arg-Arg21, which effectively destroys its parathyroid-hormone-like biological activity.	Arginine	91-94	parathyroid hormone like hormone	Homo sapiens	64-69
7744054-11	1995	These studies indicate that the preferred Kex2 cleavage site in PTHrP(1-141) is carboxy to Arg-Arg-Arg21, which effectively destroys its parathyroid-hormone-like biological activity.	Arginine	95-98	parathyroid hormone like hormone	Homo sapiens	64-69
7890620-4	1995	Human cystatin C variants with Gly substitutions for residues Arg-8, Leu-9, and/or Val-10 of the N-terminal binding region, and/or the evolutionarily conserved Trp-106 in the wedge-shaped binding region, were produced by site-directed mutagenesis and Escherichia coli expression.	Arginine	62-65	cystatin C	Homo sapiens	6-16
7890620-7	1995	In contrast, for cathepsin S inhibition these interactions are of lesser significance, as reflected by a Ki value of 10(-8) M for the cystatin C variant devoid of Arg-8, Leu-9, Val-10, and Trp-106 side chains.	Arginine	163-166	cystatin C	Homo sapiens	134-144
7766072-1	1995	The enzyme has the ability to release arginine and lysine from the carboxy terminus of peptides, and showed high specific activity against arginine (140 units mg-1 protein).	Arginine	38-46	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	159-163
7766072-1	1995	The enzyme has the ability to release arginine and lysine from the carboxy terminus of peptides, and showed high specific activity against arginine (140 units mg-1 protein).	Arginine	139-147	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	159-163
7531495-1	1995	The ability of murine macrophage nitric oxide synthase (NOS) to utilize peroxides in place of O2 and NADPH was investigated using hydrogen peroxide (H2O2), tert-butylhydroperoxide, and cumene hydroperoxide with both L-arginine and NG-hydroxy-L-arginine (L-NHA) as substrates.	Arginine	216-226	nitric oxide synthase 1, neuronal	Mus musculus	33-54
7761629-7	1995	The amino acid sequence of sturgeon GnRH is pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.	Arginine	73-76	gonadotropin releasing hormone 1	Homo sapiens	36-40
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	51-56
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Arginine	173-176	furin, paired basic amino acid cleaving enzyme	Homo sapiens	139-144
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Arginine	183-186	furin, paired basic amino acid cleaving enzyme	Homo sapiens	51-56
7852339-3	1995	Analysis of autocatalytic cleavage site mutants of furin revealed that efficient propeptide cleavage requires the presence of the complete furin cleavage consensus sequence Arg-X-Lys-Arg.	Arginine	183-186	furin, paired basic amino acid cleaving enzyme	Homo sapiens	139-144
7847389-4	1995	A genomic polymorphism of LMP7 was found strongly associated with IDDM, and the Arg/His-60 polymorphism in LMP2 was found associated with IDDM only in subjects containing an HLA DR4-DQB1*0302 haplotype.	Arginine	80-83	proteasome 20S subunit beta 9	Homo sapiens	107-111
7797268-7	1995	Nevertheless, all TCC showed an arginine residue in the N-terminal region of their TCRBV CDR3 loops.	Arginine	32-40	CDR3	Homo sapiens	89-93
7581493-4	1995	The Ahr protein has two different structures, ascribed to one amino acid replacement at codon 554 of Arg by Lys.	Arginine	101-104	aryl hydrocarbon receptor	Homo sapiens	4-7
21043620-4	1995	Thrombin-stimulated platelets but not non-stimulated platelets adhered to the SCSb-9coated surface, and platelet adherence was inhibited in a dose-dependent manner by the tetrapeptide RGDS (Arg-Gly-Asp-Ser).	Arginine	190-193	ral guanine nucleotide dissociation stimulator	Homo sapiens	184-188
7798229-2	1994	Methylglyoxal binds and irreversibly modifies arginine and lysine residues in bovine serum albumin (BSA) under physiological conditions, producing a protein with an increased net negative charge at physiological pH.	Arginine	46-54	albumin	Mus musculus	85-98
7989360-4	1994	The T104D mutant TfR lacks the O-linked carbohydrate at position 104, and is more susceptible to proteolytic cleavage at Arg-100 than the wildtype human TfR in these cells.	Arginine	121-124	transferrin receptor	Homo sapiens	17-20
7897251-8	1994	The presence of Arg and not Lys at amino acid position 23 and His at amino acid position 34 argues that IFN-alpha 2b is the major component in the Sendai virus-induced leukocyte IFN-alpha 2 and that IFN-alpha 2a is not present.	Arginine	16-19	interferon alpha 2	Homo sapiens	104-113
7878073-2	1994	The effect of chronic dietary administration of the alpha-adrenergic antagonist, prazosin, and the amino acid, L-arginine, on both the elevation of blood pressure during exposure to cold and on TH activity and expression of TH mRNA in the adrenal glands of rats was studied.	Arginine	111-121	tyrosine hydroxylase	Rattus norvegicus	194-196
7878073-2	1994	The effect of chronic dietary administration of the alpha-adrenergic antagonist, prazosin, and the amino acid, L-arginine, on both the elevation of blood pressure during exposure to cold and on TH activity and expression of TH mRNA in the adrenal glands of rats was studied.	Arginine	111-121	tyrosine hydroxylase	Rattus norvegicus	224-226
7878073-7	1994	The 3 cold-treated groups (control, L-arginine and prazosin) had increases in plasma T3 and decreases in plasma T4 and plasma renin activity.	Arginine	36-46	renin	Rattus norvegicus	126-131
8556514-2	1994	We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor.	Arginine	24-27	Fc gamma receptor IIa	Homo sapiens	71-92
7523410-3	1994	S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of L-arginine and the L-arginine-independent oxidation of NADPH by nNOS from human brain.	Arginine	98-108	nitric oxide synthase 1	Homo sapiens	162-166
7523410-3	1994	S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of L-arginine and the L-arginine-independent oxidation of NADPH by nNOS from human brain.	Arginine	117-127	nitric oxide synthase 1	Homo sapiens	162-166
7523410-8	1994	The Km of nNOS for L-arginine was 1.6 microM.	Arginine	19-29	nitric oxide synthase 1	Homo sapiens	10-14
7937939-1	1994	The Ca2+ permeability and the rectifying properties of the glutamate receptors assembled from the subunits GluR1-GluR4 depend upon a critical Arg in the GluR2 subunit located in a domain that has been proposed to span the membrane.	Arginine	142-145	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	153-158
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Arginine	283-293	interleukin 4 induced 1	Homo sapiens	75-120
7929349-2	1994	The structural basis of the multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (LAO) was investigated by determining and analyzing the structures of the protein unliganded and liganded with each of the three high-affinity ligands (L-lysine, L-arginine, and L-ornithine) and with one low-affinity ligand (L-histidine).	Arginine	283-293	interleukin 4 induced 1	Homo sapiens	122-125
7918455-7	1994	Association was substantially decreased if Cys-4057 on r-apo(a) was replaced by Arg by site-directed mutagenesis or if Cys-4057 was chemically modified.	Arginine	80-83	lipoprotein(a)	Homo sapiens	57-63
7712121-1	1994	Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.	Arginine	152-155	cerebellar degeneration related protein 2	Homo sapiens	64-68
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	173-176	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	142-146
7988304-5	1994	Individuals with two DQB1 (non-Asp) alleles and two DQA1(Arg) alleles had the highest relative risk for disease: they constituted approximately 40% of IDDM patients compared with 0% of control subjects.	Arginine	57-60	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	52-56
8067423-1	1994	The reduction in focal infarct volume after L-arginine has been attributed to an increase in regional cerebral blood flow (rCBF) within ischemic tissue.	Arginine	44-54	CCAAT/enhancer binding protein zeta	Rattus norvegicus	123-127
8067423-2	1994	We tested the hypothesis that L-arginine-induced rCBF increases precede the recovery of spontaneous electrical activity [electrocorticogram (ECoG)] in spontaneously hypertensive rats subjected to middle cerebral artery (MCA) occlusion.	Arginine	30-40	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-53
8067423-9	1994	These data demonstrate that increasing rCBF can promote functional recovery in the ischemic brain and suggest that early administration of L-arginine or other vasodilators may enhance tissue survival by increasing rCBF.	Arginine	139-149	CCAAT/enhancer binding protein zeta	Rattus norvegicus	39-43
8067423-9	1994	These data demonstrate that increasing rCBF can promote functional recovery in the ischemic brain and suggest that early administration of L-arginine or other vasodilators may enhance tissue survival by increasing rCBF.	Arginine	139-149	CCAAT/enhancer binding protein zeta	Rattus norvegicus	214-218
7749373-2	1994	The first documented mutation responsible for total human kininogen deficiency has been characterized as a single base change from CGA to TGA in exon 5, resulting in an Arg--&gt;Stop mutation inherited as an autosomal recessive trait.	Arginine	169-172	T-box transcription factor 1	Homo sapiens	138-141
8046255-2	1994	The method, requiring PCR amplification of genomic DNA and Southern analysis with allele specific oligonucleotide probes, detects a single nucleotide difference (G or A) at base 494 which results in an arginine (R) or histidine (H) at amino acid 131 of the Fc gamma RIIA protein.	Arginine	202-210	Fc gamma receptor IIa	Homo sapiens	257-270
8034638-7	1994	Prostasin has trypsin-like activity with a pH optimum of 9.0, hydrolyzing peptidyl fluorogenic substrates: D-Pro-Phe-Arg-MCA, D-Phe-Phe-Arg-MCA, D-Val-Leu-Arg-MCA, and Z-Gly-Pro-Arg-AFC.	Arginine	117-120	serine protease 8	Homo sapiens	0-9
8034645-5	1994	On the other hand, a dansyl-Glu-Gly-Arg chloromethyl ketone-treated Gla-domainless VIIa (Ki = 0.7 x 10(-7) M) showed a high affinity for TF, whereas the corresponding Gla-domainless VII similarly treated showed no binding potential, thereby indicating that binding site(s) other than in the Gla-EGF1 region are present in VIIa but not in VII.	Arginine	36-39	LOC101909187	Bos taurus	137-139
8031770-5	1994	A positively charged ring of lysine and arginine side chains encircles the PF4 tetramer sphere, presenting multiple potential sites and orientations for heparin binding.	Arginine	40-48	platelet factor 4	Homo sapiens	75-78
7947461-6	1994	Cytokine production following CD23 ligation depended on nitric oxide transduction pathway, as it was inhibited by NG-monomethyl-L-arginine, a competitive inhibitor of the conversion of L-arginine to L-citroline by nitric oxide synthase.	Arginine	128-138	Fc epsilon receptor II	Homo sapiens	30-34
7947461-9	1994	This work linked CD23 to the L-arginine-dependent transduction pathway and shows their involvement in IgE-mediated stimulation of human monocytes.	Arginine	29-39	Fc epsilon receptor II	Homo sapiens	17-21
7516596-4	1994	Using this assay, we demonstrate that an intact Rev arginine-rich domain, while critical to specific RNA binding, is dispensable for multimerization on the RRE.	Arginine	52-60	Rev	Human immunodeficiency virus 1	48-51
8024550-0	1994	Interaction between cytochrome P450 2B1 and cytochrome bs: inhibition by synthetic peptides indicates a role for P450 residues Lys-122 and Arg-125.	Arginine	139-142	cytochrome P450 2B1	Rattus norvegicus	20-39
7948575-1	1994	A cell adhesive peptide, Arg-Gly-Asp-Ser (RGDS), enhances leucocyte response to stimuli when insolubilized or conjugated with proteins.	Arginine	25-28	ral guanine nucleotide dissociation stimulator	Homo sapiens	42-46
7664048-2	1994	Molecular modelling of granzyme B indicated that the side chain of Arg 208 partially fills the specificity pocket, thus predicting the preference of this enzyme for substrates containing acidic side chains, a feature unique among eukaryotic serine proteinases.	Arginine	67-70	granzyme B	Mus musculus	23-33
7974349-3	1994	The epitopes of MAbs 418 and 522, which inhibit the binding of vWF to Factor VIII (FVIII), were localized between Leu 2 and Arg 53 and between Glu 35 and Ile 81 of the vWF subunit respectively, within the N-terminal trypsin fragment called SpIII-T4 [amino acids (aa) 1-272] which contains a binding domain for FVIII.	Arginine	124-127	coagulation factor VIII	Homo sapiens	83-88
8183282-2	1994	IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid residue in position 57 of DQ beta chain and DQA1 alleles with an arginine residue in position 52 of DQ alpha chain.	Arginine	144-152	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	123-127
8028175-6	1994	I also describe our new protein engineering technique for creation of artificial cell adhesive proteins by grafting the Arg-Gly-Asp Ser (RGDS) cell recognition signal, which was identified first in fibronectin and later in various plasma and extracellular matrix proteins.	Arginine	120-123	ral guanine nucleotide dissociation stimulator	Homo sapiens	137-141
8132607-1	1994	Integrin alpha IIb-beta 3 binds fibrinogen via the recognition sequence Arg-Gly-Asp-Ser (RGDS).	Arginine	72-75	ral guanine nucleotide dissociation stimulator	Homo sapiens	89-93
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	159-162	complement C8 beta chain	Homo sapiens	65-68
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	159-162	complement C8 beta chain	Homo sapiens	247-254
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	159-162	complement C8 beta chain	Homo sapiens	266-269
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	159-162	complement C8 beta chain	Homo sapiens	266-269
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	159-162	complement C8 beta chain	Homo sapiens	370-377
8131848-3	1994	In the present report we describe a sequence polymorphism of the C8B gene (codon 63: AGA--&gt;GGA) and demonstrate that the resulting amino acid substitution (Arg--&gt;Gly) consistently differentiates between the two common charge variants of the C8 beta chain; the C8B B allotype is characterized by an Arg and the C8B A allotype by a Gly residue in position 63 of the C8 beta polypeptide chain.	Arginine	304-307	complement C8 beta chain	Homo sapiens	65-68
7907864-5	1994	The profile of activities for intact Jurkat cells was Leu &gt; Ala &gt; Lys &gt; Arg, changing in the cytosolic fraction to Lys &gt; or = Arg &gt; Leu = Ala; the profiles for intact HL60 cells and AP-N were identical, namely Ala &gt; Leu &gt; Arg &gt; Lys.	Arginine	81-84	alanyl aminopeptidase, membrane	Homo sapiens	197-201
8070305-4	1994	The absence of aspartic acid (Asp) at position 57 of the DRB1 chain and the presence of arginine (Arg) at position 52 of the DQA1 chain correlated positively with both types of IDDM.	Arginine	88-96	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	125-129
8070305-4	1994	The absence of aspartic acid (Asp) at position 57 of the DRB1 chain and the presence of arginine (Arg) at position 52 of the DQA1 chain correlated positively with both types of IDDM.	Arginine	98-101	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	125-129
8070305-6	1994	These results suggest that the absence of Asp at position 57 of the DRB1 chain and the presence of Arg at position 52 of the DQA1 chain are significant Japanese IDDM patients and that DRB1*0802, in which the amino acid at position 57 is aspartic acid, may play a role in the pathogenesis of IDDM.	Arginine	99-102	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	125-129
7513384-5	1994	Addition of L-arginine (3 mM) 5 min before L-NNA completely prevented the L-NNA-inhibition of CGRP-induced relaxations.	Arginine	12-22	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
7513384-7	1994	The data suggest that de novo synthesis of nitric oxide from its precursor L-arginine is required for rCGRP to induce vasodilations and elevations of both cyclic AMP and cyclic GMP levels in rat aorta.	Arginine	75-85	calcitonin-related polypeptide alpha	Rattus norvegicus	102-107
7905001-2	1994	Glutamate 203 of the C alpha isoform (C alpha E203) has been implicated in the binding of the arginine 15 residue of the skeletal isoform of PKI (PKI alpha R15) (Knighton, D. R., Zheng, J., Ten Eyck, L. F., Xuong, N., Taylor, S.S., and Sowadski, J. M. (1991) Science 253, 414-420).	Arginine	94-102	protein kinase inhibitor, alpha	Mus musculus	141-144
7905001-2	1994	Glutamate 203 of the C alpha isoform (C alpha E203) has been implicated in the binding of the arginine 15 residue of the skeletal isoform of PKI (PKI alpha R15) (Knighton, D. R., Zheng, J., Ten Eyck, L. F., Xuong, N., Taylor, S.S., and Sowadski, J. M. (1991) Science 253, 414-420).	Arginine	94-102	protein kinase inhibitor, alpha	Mus musculus	146-155
7865286-4	1994	These results together with the data from cotransfection experiments show that SIV can be attenuated up to 95% by introducing changes into the arginine-rich domain, RBR, of Rev.	Arginine	143-151	Rev	Human immunodeficiency virus 1	173-176
7581746-2	1994	Both purified enzymes hydrolyse HHL in a radiochemical assay with the same optimal pH, a characteristic divalent metal requirement, a close similar behavior against inhibitors of other metallopeptidases, such as enkephalinase and kininase I, and the involvement of arginine and lysine residues in their active site.	Arginine	265-273	hes family bHLH transcription factor 1	Homo sapiens	32-35
7511743-6	1994	dose of N omega-nitro-L-arginine methyl ester (L-NAME, 20 mg/kg) almost suppressed (-90%) the cardiovascular effects of bFGF, an effect that was restored by a single dose of L-arginine (100 mg/kg i.v.).	Arginine	22-32	fibroblast growth factor 2	Rattus norvegicus	120-124
8262934-0	1993	Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.	Arginine	63-71	farnesyl diphosphate synthase	Rattus norvegicus	86-115
8262934-6	1993	In order to determine the importance of these domains in catalysis, the conserved aspartates or arginines in domains I and II of rat farnesyl diphosphate synthase were individually mutated to glutamate or lysine, respectively.	Arginine	96-105	farnesyl diphosphate synthase	Rattus norvegicus	133-162
8280139-7	1993	These three mutations result in changes of glycine to arginine and of tyrosine to aspartic acid at amino acid positions 71 and 486 of the UGT1A protein, and of leucine to proline and of tyrosine to aspartic acid at amino acid positions 132 and 487 of the UGT1D protein, respectively.	Arginine	54-62	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	138-143
8307321-3	1993	Three mutations in sqt-1 and one in rol-6 that cause dominant right-handed helical twisting (RRol) of animals are arginine to cysteine replacements.	Arginine	114-122	Cuticle collagen rol-6	Caenorhabditis elegans	36-41
8307321-5	1993	A recessive RRol mutation of rol-6 is a replacement of one of the same conserved arginines by histidine.	Arginine	81-90	Cuticle collagen rol-6	Caenorhabditis elegans	29-34
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Arginine	66-69	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	112-117
8227051-1	1993	Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-.	Arginine	142-145	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8227051-1	1993	Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-.	Arginine	152-155	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8227051-1	1993	Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-.	Arginine	152-155	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8227054-3	1993	Specifically, TrfA proteins with deletions or substitutions of the terminal cysteine, lysine, and arginine (codons 380-382, respectively) were constructed and characterized for their ability to initiate replication from an RK2 origin in vivo in E. coli, Azotobacter vinelandii, Pseudomonas putida, and Agrobacterium tumefaciens and for binding activity to the iterons at the replication origin.	Arginine	98-106	TrfA-like protein	Escherichia coli	14-18
8227054-4	1993	Substitutions of the cysteine at position 380 with a glycine or an arginine resulted in a TrfA protein defective in binding to the RK2 origin and, therefore, defective in replication initiation activity in all four Gram-negative bacteria.	Arginine	67-75	TrfA-like protein	Escherichia coli	90-94
8227054-8	1993	Substitution of this terminal arginine with alanine, serine, or glutamic acid also produced replication-defective TrfA protein in all four bacterial hosts while not affecting iteron binding activity.	Arginine	30-38	TrfA-like protein	Escherichia coli	114-118
8227054-10	1993	These observations suggest that the terminal arginine plays an essential role in the activity of the TrfA protein, possibly interaction with host proteins, which can be separated from its iteron binding activity.	Arginine	45-53	TrfA-like protein	Escherichia coli	101-105
8143901-8	1993	Five residues (Leu-86, Cys-88, Cys-90, Arg-94, and Arg-95) were critical for maximal inhibition of hCG binding by CG beta 81-95.	Arginine	39-42	chorionic gonadotropin subunit beta 5	Homo sapiens	99-102
8143901-8	1993	Five residues (Leu-86, Cys-88, Cys-90, Arg-94, and Arg-95) were critical for maximal inhibition of hCG binding by CG beta 81-95.	Arginine	51-54	chorionic gonadotropin subunit beta 5	Homo sapiens	99-102
8216224-5	1993	values for the other serpins tested (protease nexin I, protein C inhibitor, and mutants of alpha 1-antichymotrypsin and alpha 1-antitrypsin with P1 arginine residues) were at least 1000-fold higher, with P1-Arg-alpha 1-antitrypsin (kass.	Arginine	148-156	serpin family A member 5	Homo sapiens	55-74
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	Arginine	138-148	nitric oxide synthase 1, neuronal	Mus musculus	101-112
8230321-2	1993	Both EGF and NGF result in the induction of the primary response gene egr-1/TIS8 and increased methylation of a variety of membrane-associated proteins as early as 5 min after EGF or NGF treatment using a methylation assay that detects methyl esters as well as methylated arginine residues.	Arginine	272-280	epidermal growth factor like 1	Rattus norvegicus	5-8
8344522-4	1993	The predicted DnaK sequence has a high Lys:Arg ratio which is not typical of streptomycete proteins.	Arginine	43-46	dnaK	Streptomyces coelicolor A3(2)	14-18
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Arginine	75-83	endothelin receptor type A	Homo sapiens	60-63
8409983-7	1993	The interaction appears to involve a hydrogen bond with the eta-protons of arginine"s guanido group acting as donor and tyrosine"s phenolic eta-oxygen as acceptor.	Arginine	75-83	endothelin receptor type A	Homo sapiens	140-143
8339246-1	1993	The Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from the laminin B1 chain has been shown to decrease tumor growth and metastasis.	Arginine	20-23	laminin B1	Mus musculus	57-73
8344203-2	1993	Furin cleaves the concensus processing site -Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1-.	Arginine	45-48	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-5
8321192-8	1993	Within the NFKB1 portion of this fusion protein, a single amino acid change of His to Arg altered the DNA-binding specificity to favor interaction with the RelA-selective DNA motif.	Arginine	86-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	156-160
7686743-1	1993	Nitric oxide (NO), generated from L-arginine by an enzymatic reaction of a NO synthase (NOS; EC 1.14.23), is a recently identified biological mediator suggested to be involved in a wide variety of biological processes.	Arginine	34-44	nitric oxide synthase 1, neuronal	Mus musculus	75-86
7685744-6	1993	Computer modeling of the MUC-1 immunoreactive glycopeptide containing the H type-3 trisaccharide alpha Fuc 1-2 beta Gal 1-3 alpha GalNAc- bound to the threonine of the PDTRP-pentapeptide shows that the peptide epitope might be masked when the fucose is positioned over the arginine.	Arginine	273-281	mucin 1, cell surface associated	Homo sapiens	25-30
8392392-4	1993	Proteinases recognize a specific peptide, termed the reactive site, near the carboxyl-terminus of serpins (for antithrombin and protein C inhibitor this is Arg-Ser and for heparin cofactor II this is Leu-Ser).	Arginine	156-159	serpin family A member 5	Homo sapiens	128-147
8494891-2	1993	In contrast, chemical modification decreases activity toward S-(hydroxymethyl)glutathione (FDH activity) and 12-hydroxydodecanoic acid by increasing Km, pointing to a role for arginine in binding anionic substrates.	Arginine	176-184	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	91-94
8487299-5	1993	Single mutations of all four charged amino acids in the transmembrane segments of AAC2 (K38A, R96D, R96H, R96L, R96P, R204L, R294A) resulted in loss of function, as did mutations in the matrix arginine cluster (R252I, R253I, R254I).	Arginine	193-201	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	82-86
8463322-0	1993	Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin.	Arginine	55-58	vinculin	Homo sapiens	172-180
8471031-1	1993	Human cystatin C variants in which the evolutionarily conserved Gly-11 residue has been replaced by residues with positively charged (Arg), negatively charged (Glu), bulky hydrophobic (Trp), or small (Ser or Ala) side-chains have been produced by site-directed mutagenesis and expression in Escherichia coli.	Arginine	134-137	cystatin C	Homo sapiens	6-16
8471031-9	1993	The Ki values for the interactions with papain of these three N-terminal-decapeptide-lacking cystatin C variants were 20-50 nM, just one order of magnitude higher than the value for N-terminally truncated wild-type cystatin C, which in turn was similar to the corresponding values for the full-length Glu-11, Arg-11 and Trp-11 variants.	Arginine	309-312	cystatin C	Homo sapiens	93-103
8445721-2	1993	The mutant env had a point mutation which resulted in a Cys-to-Arg substitution at the 361st amino acid in the FMLV envelope protein (Env).	Arginine	63-66	envelope protein	Friend murine leukemia virus	11-14
8445721-2	1993	The mutant env had a point mutation which resulted in a Cys-to-Arg substitution at the 361st amino acid in the FMLV envelope protein (Env).	Arginine	63-66	envelope protein	Friend murine leukemia virus	116-132
8445721-2	1993	The mutant env had a point mutation which resulted in a Cys-to-Arg substitution at the 361st amino acid in the FMLV envelope protein (Env).	Arginine	63-66	envelope protein	Friend murine leukemia virus	134-137
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	47-55	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	107-111
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	159-167	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	107-111
8294080-2	1993	Regardless of its origin, endogenous NO is produced through the conversion of L-arginine to L-citrulline by NO-synthase (NOS) from which several isoforms have recently been isolated, purified and cloned.	Arginine	78-88	nitric oxide synthase 1	Homo sapiens	108-119
8373751-1	1993	A tetrapeptide RGDS (Arg-Gly-Asp-Ser), which is one of the active sites of cell adhesive proteins, was synthesized according to the solution method and covalently coupled onto monodisperse microspheres.	Arginine	21-24	ral guanine nucleotide dissociation stimulator	Homo sapiens	15-19
1281426-0	1992	Identification of functional arginines in human angiogenin by site-directed mutagenesis.	Arginine	29-38	angiogenin	Homo sapiens	48-58
1281426-1	1992	Chemical modifications of human angiogenin had suggested that arginines are essential for its ribonucleolytic activity [Shapiro, R., Weremowicz, S., Riordan, J. F., &amp; Vallee, B. L. (1987) Proc.	Arginine	62-71	angiogenin	Homo sapiens	32-42
1281426-8	1992	R5A-angiogenin, while nearly fully active toward dinucleotides, is one-fourth as active as angiogenin toward tRNA, suggesting that Arg-5 may participate in the binding of peripheral components of the substrate.	Arginine	131-134	angiogenin	Homo sapiens	4-14
1281426-8	1992	R5A-angiogenin, while nearly fully active toward dinucleotides, is one-fourth as active as angiogenin toward tRNA, suggesting that Arg-5 may participate in the binding of peripheral components of the substrate.	Arginine	131-134	angiogenin	Homo sapiens	91-101
1281426-10	1992	These results, together with its position in the calculated three-dimensional structure of angiogenin, imply an indirect role for Arg-33 in catalysis.	Arginine	130-133	angiogenin	Homo sapiens	91-101
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Arginine	27-30	nidogen 1	Homo sapiens	55-63
1469085-6	1992	A synthetic peptide of the Arg-Gly-Asp (RGD) domain in entactin, SIGFRGDGQTC (S-RGD), mediated PMN adhesion and chemotaxis, and preexposure of PMN to S-RGD blocked PMN adhesion and chemotaxis induced by entactin without diminishing the adhesive and chemotactic activities of fMLP.	Arginine	27-30	nidogen 1	Homo sapiens	203-211
1360148-2	1992	Fusion activity requires proteolytic cleavage of the gp160 protein into gp120 and gp41 at a site containing several arginine and lysine residues.	Arginine	116-124	glutamyl aminopeptidase	Homo sapiens	53-58
1360148-5	1992	Furin, a subtilisin-like eukaryotic endoprotease, has a substrate specificity for the consensus amino-acid sequence Arg-X-Lys/Arg-Arg at the cleavage site.	Arginine	116-119	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-48
1360148-5	1992	Furin, a subtilisin-like eukaryotic endoprotease, has a substrate specificity for the consensus amino-acid sequence Arg-X-Lys/Arg-Arg at the cleavage site.	Arginine	126-129	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-48
1360148-5	1992	Furin, a subtilisin-like eukaryotic endoprotease, has a substrate specificity for the consensus amino-acid sequence Arg-X-Lys/Arg-Arg at the cleavage site.	Arginine	126-129	furin, paired basic amino acid cleaving enzyme	Homo sapiens	0-48
1360174-4	1992	Another mutation in the second family was a change from C to T in the codon of CGA for Arg 197 also forming a stop codon of TGA, which was confirmed by PCR-HaeIII digestion.	Arginine	87-90	T-box transcription factor 1	Homo sapiens	124-127
1301916-9	1992	A CpG mutational hot spot was identified at the position for Arg-51 in the HPRT protein.	Arginine	61-64	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	75-79
1644824-1	1992	Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells.	Arginine	180-183	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
1644824-1	1992	Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells.	Arginine	189-192	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
1644824-1	1992	Previous work demonstrated that human furin is a predominantly Golgi membrane-localized endoprotease that can efficiently process precursor proteins at paired basic residues (-Lys-Arg- or -Arg-Arg-) in transfected cells.	Arginine	189-192	furin, paired basic amino acid cleaving enzyme	Homo sapiens	38-43
1644824-5	1992	Evidence that furin may require a P4 Arg in fluorogenic peptide substrates suggested that this enzyme might cleave the protective antigen (PA) component of anthrax toxin at the sequence -Arg-Lys-Lys-Arg-.	Arginine	37-40	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
1644824-5	1992	Evidence that furin may require a P4 Arg in fluorogenic peptide substrates suggested that this enzyme might cleave the protective antigen (PA) component of anthrax toxin at the sequence -Arg-Lys-Lys-Arg-.	Arginine	187-190	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
1644824-5	1992	Evidence that furin may require a P4 Arg in fluorogenic peptide substrates suggested that this enzyme might cleave the protective antigen (PA) component of anthrax toxin at the sequence -Arg-Lys-Lys-Arg-.	Arginine	187-190	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
1644824-6	1992	Indeed, PA was cleaved by purified furin at the proposed consensus site (-Arg-X-Lys/Arg-Arg decreases-) at a rate (8 mumol/min/mg total protein) 400-fold higher than that observed with synthetic peptides.	Arginine	74-77	furin, paired basic amino acid cleaving enzyme	Homo sapiens	35-40
1644824-6	1992	Indeed, PA was cleaved by purified furin at the proposed consensus site (-Arg-X-Lys/Arg-Arg decreases-) at a rate (8 mumol/min/mg total protein) 400-fold higher than that observed with synthetic peptides.	Arginine	84-87	furin, paired basic amino acid cleaving enzyme	Homo sapiens	35-40
1644824-7	1992	In addition, the processing of mutant PA molecules with altered cleavage sites suggests that furin-catalyzed endoproteolysis minimally requires an -Arg-X-X-Arg- recognition sequence for efficient cleavage.	Arginine	148-151	furin, paired basic amino acid cleaving enzyme	Homo sapiens	93-98
1644824-7	1992	In addition, the processing of mutant PA molecules with altered cleavage sites suggests that furin-catalyzed endoproteolysis minimally requires an -Arg-X-X-Arg- recognition sequence for efficient cleavage.	Arginine	156-159	furin, paired basic amino acid cleaving enzyme	Homo sapiens	93-98
1379468-1	1992	Nitric oxide synthase (NOS) (EC 1.14.23) catalyzes the oxidation of L-arginine to citrulline and nitric oxide.	Arginine	68-78	nitric oxide synthase 1, neuronal	Mus musculus	0-21
1420981-6	1992	We have synthesized an anionic melittin analogue of MLT (E-MLT; net charge -4) in which all five lysine and arginine residues are replaced with glutamate, and acetyl and succinyl derivatives of E-MLT (net charges -5 and -6).	Arginine	108-116	MALT1 paracaspase	Homo sapiens	52-55
1639060-4	1992	In the present study we have performed binding studies between protein 4.1 and AE1 using peptides and corresponding idiotypic and anti-idiotypic antibodies to show that arginine-rich clusters of the cytoplasmic domain of AE1 (IRRRY/LRRRY) serve as a major binding site for a motif with opposite charge and identical hydrophobicity present on the membrane-binding domain of protein 4.1 (LEEDY).	Arginine	169-177	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	79-82
1639060-4	1992	In the present study we have performed binding studies between protein 4.1 and AE1 using peptides and corresponding idiotypic and anti-idiotypic antibodies to show that arginine-rich clusters of the cytoplasmic domain of AE1 (IRRRY/LRRRY) serve as a major binding site for a motif with opposite charge and identical hydrophobicity present on the membrane-binding domain of protein 4.1 (LEEDY).	Arginine	169-177	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	221-224
1386484-6	1992	When the three arginines were substituted with aspartic acids, the mutant nsP2 was localized in the cytoplasm.	Arginine	15-24	reticulon 2	Homo sapiens	74-78
1640457-0	1992	Binding of the arginine repressor of Escherichia coli K12 to its operator sites.	Arginine	15-23	repressor	Escherichia coli	24-33
1640457-3	1992	The hexameric arginine repressor, the product of argR, binds to the two ARG boxes in an operator in the presence of L-arginine.	Arginine	14-22	repressor	Escherichia coli	23-32
1640457-3	1992	The hexameric arginine repressor, the product of argR, binds to the two ARG boxes in an operator in the presence of L-arginine.	Arginine	72-75	repressor	Escherichia coli	23-32
1640457-3	1992	The hexameric arginine repressor, the product of argR, binds to the two ARG boxes in an operator in the presence of L-arginine.	Arginine	116-126	repressor	Escherichia coli	23-32
1640457-4	1992	From the results of various kinds of in vitro footprinting experiments with the ARG boxes of argF and argR (DNase I protection, hydroxyl radical, ethylation and methylation interference, methylation protection) it can be concluded that: (1) the repressor binds simultaneously to two adjacent ARG boxes; (2) that it binds on one face of the double helix; and (3) that it forms contacts with the major and minor grooves of each ARG box, but not with the central three base-pairs.	Arginine	80-83	repressor	Escherichia coli	245-254
1640457-5	1992	The repressor can bind also to a single ARG box, but its affinity is about 100-fold lower than for two ARG boxes.	Arginine	40-43	repressor	Escherichia coli	4-13
1640457-5	1992	The repressor can bind also to a single ARG box, but its affinity is about 100-fold lower than for two ARG boxes.	Arginine	103-106	repressor	Escherichia coli	4-13
1640457-9	1992	The main features that distinguish the arginine repressor from other repressors studied in E. coli are its hexameric nature and the simultaneous binding of one hexameric molecule to two palindromic ARG boxes that are close to each other.	Arginine	39-47	repressor	Escherichia coli	48-57
1640457-9	1992	The main features that distinguish the arginine repressor from other repressors studied in E. coli are its hexameric nature and the simultaneous binding of one hexameric molecule to two palindromic ARG boxes that are close to each other.	Arginine	198-201	repressor	Escherichia coli	48-57
1629222-1	1992	Human furin is a calcium-dependent serine endoprotease that can efficiently cleave many precursor proteins on the carboxyl side of the consensus cleavage sequence, -Arg-X-Lys/Arg-Arg-, both in vivo and in vitro.	Arginine	165-168	furin, paired basic amino acid cleaving enzyme	Homo sapiens	6-11
1629222-1	1992	Human furin is a calcium-dependent serine endoprotease that can efficiently cleave many precursor proteins on the carboxyl side of the consensus cleavage sequence, -Arg-X-Lys/Arg-Arg-, both in vivo and in vitro.	Arginine	175-178	furin, paired basic amino acid cleaving enzyme	Homo sapiens	6-11
1629222-1	1992	Human furin is a calcium-dependent serine endoprotease that can efficiently cleave many precursor proteins on the carboxyl side of the consensus cleavage sequence, -Arg-X-Lys/Arg-Arg-, both in vivo and in vitro.	Arginine	175-178	furin, paired basic amino acid cleaving enzyme	Homo sapiens	6-11
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Arginine	283-286	furin, paired basic amino acid cleaving enzyme	Homo sapiens	44-49
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Arginine	283-286	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Arginine	283-286	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
1629222-4	1992	Here we report identification of the 90-kDa furin NH2 terminus and, based on the reported sequence of the furin cDNA, demonstrate that this furin protein is derived from a larger precursor by an endoproteolytic cleavage on the COOH-terminal side of a consensus furin cleavage site, -Arg-Thr-Lys-Arg107-.	Arginine	283-286	furin, paired basic amino acid cleaving enzyme	Homo sapiens	106-111
1637938-8	1992	On the basis of putative cleavage sites on the SP-10 sequence, endoproteases that act at five different peptide bonds are predicted to cleave SP-10: these hydrolyze following arginine (a trypsin-like protease, possibly acrosin), and following serine, proline, glycine, and glutamic acid (previously undescribed intra-acrosomal protease specificities).	Arginine	175-183	acrosomal vesicle protein 1	Homo sapiens	47-52
1637938-8	1992	On the basis of putative cleavage sites on the SP-10 sequence, endoproteases that act at five different peptide bonds are predicted to cleave SP-10: these hydrolyze following arginine (a trypsin-like protease, possibly acrosin), and following serine, proline, glycine, and glutamic acid (previously undescribed intra-acrosomal protease specificities).	Arginine	175-183	acrosomal vesicle protein 1	Homo sapiens	142-147
1350560-4	1992	Further studies with a series of back-mutants of the ftz-msh chimera have revealed that a set of class-specific DNA backbone-contacting residues in the HTH, particularly Arg-28 and Arg-43, are required for efficient target site recognition and, hence, full ftz activity both in vitro and in vivo.	Arginine	170-173	fushi tarazu	Drosophila melanogaster	53-56
1350560-4	1992	Further studies with a series of back-mutants of the ftz-msh chimera have revealed that a set of class-specific DNA backbone-contacting residues in the HTH, particularly Arg-28 and Arg-43, are required for efficient target site recognition and, hence, full ftz activity both in vitro and in vivo.	Arginine	170-173	fushi tarazu	Drosophila melanogaster	257-260
1350560-4	1992	Further studies with a series of back-mutants of the ftz-msh chimera have revealed that a set of class-specific DNA backbone-contacting residues in the HTH, particularly Arg-28 and Arg-43, are required for efficient target site recognition and, hence, full ftz activity both in vitro and in vivo.	Arginine	181-184	fushi tarazu	Drosophila melanogaster	53-56
1350560-4	1992	Further studies with a series of back-mutants of the ftz-msh chimera have revealed that a set of class-specific DNA backbone-contacting residues in the HTH, particularly Arg-28 and Arg-43, are required for efficient target site recognition and, hence, full ftz activity both in vitro and in vivo.	Arginine	181-184	fushi tarazu	Drosophila melanogaster	257-260
1618489-1	1992	A nonsense mutation at the CpG-site in the codon for Arg(169) in the gene for hypoxanthine phosphoribosyltransferase (hprt) was identified by genomic polymerase chain reaction (PCR) and DNA sequencing in cultured fibroblasts from two brothers with Lesch Nyhan"s syndrome.	Arginine	53-56	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	78-116
1618489-1	1992	A nonsense mutation at the CpG-site in the codon for Arg(169) in the gene for hypoxanthine phosphoribosyltransferase (hprt) was identified by genomic polymerase chain reaction (PCR) and DNA sequencing in cultured fibroblasts from two brothers with Lesch Nyhan"s syndrome.	Arginine	53-56	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	118-122
1500420-8	1992	Comparison of the data with the known primary structure of histone H2A revealed their amino acid sequence as 1Ser-Gly-Arg.	Arginine	118-121	histone cluster 1 H2A family member F	Rattus norvegicus	59-70
1382726-7	1992	Peptides from plasmin digestion of fibronectin containing cell attachment site with sequence Arg-Gly-Asp-Ser and also synthetic peptide reproducing this amino-acid sequence at the concentration of 1000 micrograms/ml released about 50% of collagenase and 55% of elastase from PMN-leukocytes.	Arginine	93-96	plasminogen	Homo sapiens	14-21
1597855-3	1992	Incorporation of the tripeptide sequence Arg-Gly-Asp (RGD), a common structural element of many integrin ligands, into cyclic peptides produced a series of peptides of the general structure BrAc-(AA1)-RGD-Cys-OH, which were prepared by solid-phase peptide synthesis.	Arginine	41-44	AA1	Homo sapiens	196-199
1571548-11	1992	These data indicate that both the P4 arginine and the P2 lysine play an important role in substrate recognition by PACE.	Arginine	37-45	furin, paired basic amino acid cleaving enzyme	Homo sapiens	115-119
1570352-3	1992	The special characteristic of all four GHRH analogs is that arginine was replaced by agmatine (Agm) in Position 29.	Arginine	60-68	growth hormone releasing hormone	Bos taurus	39-43
1550128-5	1992	The mutation present in the ATP 6 gene results in the substitution of an arginine residue for a leucine.	Arginine	73-81	mitochondrially encoded ATP synthase 6	Homo sapiens	28-33
1378874-0	1992	Characterization of monoclonal antibody 436 recognizing the Arg-Pro-Ala-Pro sequence of the polymorphic epithelial mucin (PEM) protein core in breast carcinoma cells.	Arginine	60-63	mucin 1, cell surface associated	Homo sapiens	92-120
1378874-0	1992	Characterization of monoclonal antibody 436 recognizing the Arg-Pro-Ala-Pro sequence of the polymorphic epithelial mucin (PEM) protein core in breast carcinoma cells.	Arginine	60-63	mucin 1, cell surface associated	Homo sapiens	122-125
1624955-1	1992	Many adhesive proteins present in extracellular matrices and in blood contain the tetrapeptide sequence -Arg-Gly-Asp-Ser- (or RGDS) at their cell recognition site.	Arginine	105-108	ral guanine nucleotide dissociation stimulator	Homo sapiens	126-130
1547220-3	1992	Activated protein C inactivates thrombin-activated FVIII through cleavage adjacent to position Arg 336 in the cofactor.	Arginine	95-98	coagulation factor VIII	Homo sapiens	51-56
1547220-6	1992	Incubation of these two proteins at equimolar or close to equimolar concentrations resulted in the inactivation of FVIII, coincident with cleavage of the FVIII heavy chain adjacent to Arg 336 and the light chain adjacent to Arg 1719.	Arginine	184-187	coagulation factor VIII	Homo sapiens	115-120
1547220-6	1992	Incubation of these two proteins at equimolar or close to equimolar concentrations resulted in the inactivation of FVIII, coincident with cleavage of the FVIII heavy chain adjacent to Arg 336 and the light chain adjacent to Arg 1719.	Arginine	184-187	coagulation factor VIII	Homo sapiens	154-159
1547220-6	1992	Incubation of these two proteins at equimolar or close to equimolar concentrations resulted in the inactivation of FVIII, coincident with cleavage of the FVIII heavy chain adjacent to Arg 336 and the light chain adjacent to Arg 1719.	Arginine	224-227	coagulation factor VIII	Homo sapiens	115-120
1376275-3	1992	of mice with L-arginine but not D-arginine potentiated beta-endorphin-induced (i.c.v.	Arginine	13-23	pro-opiomelanocortin-alpha	Mus musculus	55-69
1376275-6	1992	This observation suggests that increased production of nitric oxide from L-arginine mediates the potentiation of beta-endorphin-induced antinociception.	Arginine	73-83	pro-opiomelanocortin-alpha	Mus musculus	113-127
1581215-4	1992	Direct sequencing of the amplified fragment, which encodes for the FVIII-binding domain, showed a single nucleotide change in exon 20 at codon 854, resulting in the substitution of CAG glutamine (Gln) for CGG arginine (Arg).	Arginine	219-222	coagulation factor VIII	Homo sapiens	67-72
1531588-6	1992	During digestion of fibrinogen at low plasmin concentration, up to 65% of the FpA was cleaved just subsequent to the progressive release of B beta-(1-42)-peptide, and the Arg-16-Gly-17 bond of the A alpha-chain became relatively stable towards plasmin action when present in fragment E (and possibly fragment Y).	Arginine	171-174	plasminogen	Homo sapiens	38-45
1730390-1	1992	Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the protein.	Arginine	176-179	fibronectin 1 S homeolog	Xenopus laevis	42-53
1730390-1	1992	Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the protein.	Arginine	176-179	fibronectin 1 S homeolog	Xenopus laevis	55-57
1567180-6	1992	Although the function of this protein in tumor cells is not known, OPN contains a conserved GRGDS (glycine-arginine-glycine-aspartic acid-serine) amino acid sequence, which may function as a cell attachment site for this protein.	Arginine	107-115	secreted phosphoprotein 1	Mus musculus	67-70
1752440-6	1991	In contrast, the arginine-rich region of Tat, which is required for binding to TAR RNA, is dispensable for the function of DNA-bound Tat.	Arginine	17-25	tyrosine aminotransferase	Homo sapiens	41-44
1658005-12	1991	The partially purified enzyme phosphorylated myelin basic protein, a characteristic substrate of microtubule-associated protein-2 kinase (MAP-2 kinase) and the peptide Arg-Arg-Arg-(Tyr-Ser-Pro-Thr-Ser-Pro-Ser)4 from RNA polymerase II.	Arginine	168-171	myelin basic protein	Mus musculus	45-65
1658005-12	1991	The partially purified enzyme phosphorylated myelin basic protein, a characteristic substrate of microtubule-associated protein-2 kinase (MAP-2 kinase) and the peptide Arg-Arg-Arg-(Tyr-Ser-Pro-Thr-Ser-Pro-Ser)4 from RNA polymerase II.	Arginine	172-175	myelin basic protein	Mus musculus	45-65
1939150-10	1991	These results confirm the importance of the P1 arginine residue of APP-KD in determining inhibitory specificity, and are also the first time that a single amino acid replacement has been shown to generate a specific potent human neutrophil elastase inhibitor from a human KD sequence.	Arginine	47-55	elastase, neutrophil expressed	Homo sapiens	229-248
1939157-4	1991	A plausible sequence of proteolytic cleavages that could generate the 79-residue form of MGP would be a trypsin-like cleavage at Arg80-Arg81 or Arg81-Gly82 followed by carboxypeptidase B-like cleavage to remove COOH-terminal arginine(s).	Arginine	225-233	matrix Gla protein	Homo sapiens	89-92
1718750-2	1991	One peptide, His-Gly-Arg-Val-Gly-Ile-Tyr-Phe-Gly-Met-Lys (peptide 11; Ile, isoleucine) is antigenic and binds with a high affinity to a monoclonal antibody that recognizes the native beta 2 subunit.	Arginine	21-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	183-189
1797805-1	1991	Materials to enhance cell adhesion were synthesized by surface integration of peptide, Arg-Gly-Asp-Ser(RGDS), which is an active-site sequence of cell-adhesive proteins.	Arginine	87-90	ral guanine nucleotide dissociation stimulator	Homo sapiens	103-107
1787825-1	1991	Amylin is a proteinaceous hormone secreted form insulin-producing pancreatic beta-cells following stimulation by food molecules such as glucose and arginine.	Arginine	148-156	islet amyloid polypeptide	Homo sapiens	0-6
1680393-1	1991	Histidine-containing protein, HPr, of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system has an active site that involves His-15, which is phosphorylated to form a N delta 1-P-histidine, Arg-17, and the carboxy-terminal residue Glu-85.	Arginine	209-212	haptoglobin-related protein	Homo sapiens	30-33
1892828-4	1991	Peptides RP70 and RP142 showed evidence for the presence of a significant population of conformations containing a beta-turn in the conserved sequence Gly-Pro-Gly-Arg.	Arginine	163-166	pre-mRNA processing factor 4	Homo sapiens	9-13
1896467-2	1991	Contained within p54 is an arginine/serine-rich region similar to segments of several proteins that participate in pre-mRNA splicing including the 70-kDa component of U1 small nuclear and "suppressor-of-white-apricot" proteins.	Arginine	27-35	interferon induced protein with tetratricopeptide repeats 2	Homo sapiens	17-20
1889406-3	1991	Protamine HP4 contains high amounts of arginine, cysteine and histidine.	Arginine	39-47	defensin alpha 4	Homo sapiens	10-13
1715886-2	1991	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine.	Arginine	143-151	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	0-38
1715886-2	1991	Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine.	Arginine	143-151	myelin basic protein	Homo sapiens	40-43
1679326-3	1991	We measured amylin secretion from HIT T15 beta-cells exposed to glucose, arginine, glucagon, somatostatin, tolbutamide, glyburide, or metformin.	Arginine	73-81	islet amyloid polypeptide	Mesocricetus auratus	12-18
1830244-5	1991	SF2 has a C-terminal region rich in arginine-serine dipeptides, similar to the RS domains of the U1 snRNP 70K polypeptide and the Drosophila alternative splicing regulators transformer, transformer-2, and suppressor-of-white-apricot.	Arginine	36-44	Splicing factor 2	Drosophila melanogaster	0-3
1905715-0	1991	Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.	Arginine	0-3	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
1905715-0	1991	Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.	Arginine	10-13	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
1905715-0	1991	Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway.	Arginine	10-13	furin, paired basic amino acid cleaving enzyme	Homo sapiens	72-77
1710829-5	1991	The properties of heteromeric wild-type and mutant GluRs revealed that the dominance of GluR-B is due to the arginine residue in the TM2 region.	Arginine	109-117	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	88-94
1857778-3	1991	The first phase of L-arginine-stimulated insulin release was also potentiated by pancreastatin (6.9 +/- 0.5 ng/5 min in controls, 8.4 +/- 0.6 ng/5 min in pancreastatin group), but not by CGA.	Arginine	19-29	chromogranin A	Rattus norvegicus	187-190
1709522-6	1991	Model building suggests that the arginine eta nitrogens and the epsilon nitrogen can form specific networks of hydrogen bonds with adjacent pairs of phosphates and that these arrangements are likely to occur near RNA loops and bulges and not within double-stranded A-form RNA.	Arginine	33-41	endothelin receptor type A	Homo sapiens	42-45
1649382-1	1991	In reconstituted rabbit skeletal muscle (Ca2+ + Mg2+)-ATPase proteoliposomes, Ca(2+)-uptake is decreased by more than 90% with T2 cleavage (Arg-198).	Arginine	140-143	plasma membrane calcium-transporting ATPase 1	Oryctolagus cuniculus	41-60
2017168-2	1991	The Ste2 and beta la components were linked by a processing fragment (P) from the yeast killer preprotoxin containing a C-terminal lysine-arginine site for cleavage by the Golgi-associated Kex2 protease.	Arginine	138-146	alpha-factor pheromone receptor STE2	Saccharomyces cerevisiae S288C	4-8
1654780-0	1991	NMR evidence for perturbation of the copper coordination sphere upon chemical modification of arginine 141 in bovine Cu,Zn superoxide dismutase.	Arginine	94-102	superoxide dismutase [Cu-Zn]	Bos taurus	117-143
1654780-1	1991	The reaction of the Cu,Co derivative of bovine Cu,Zn superoxide dismutase with phenylglyoxal or butanedione, which are known to inactivate the enzyme by selectively binding to Arg 141, has been studied by 1H NMR.	Arginine	176-179	superoxide dismutase [Cu-Zn]	Bos taurus	47-73
2149585-4	1990	The Ca2+ - Ca2+ intersite distance is estimated to be 8-9 A and the average distance from the Ca2+ sites to CrATP is about 18 A. Digestion of the (Ca2+ + Mg2+)-ATPase at the T2 site (Arg 198) causes uncoupling of Ca2(+)-transport from ATPase activity while calcium occlusion due to E1-P formation remains unchanged.	Arginine	183-186	dynein axonemal heavy chain 8	Homo sapiens	160-166
1979502-6	1990	Further novel C----T transitions were identified in the remaining arginine codons screened (-5, 427, 583, 795, and 1696), resulting in the creation of TGA termination codons.	Arginine	66-74	T-box transcription factor 1	Homo sapiens	151-154
1963807-7	1990	Similarly, pretreatment of the cells with the L-arginine analogues, L-canavanine (IC50 60 microM) or NG-monomethyl-L-arginine (IC50 2.5 microM), inhibited the cyclic GMP response to endothelin-1.	Arginine	46-56	5'-nucleotidase, cytosolic II	Mus musculus	166-169
1963807-10	1990	The Ca2+ ionophore ionomycin induced a transient rise in cyclic GMP levels, which was also suppressed by preincubation in the presence of either haemoglobin or the L-arginine analogues L-canavanine or NG-monomethyl-L-arginine.	Arginine	164-174	5'-nucleotidase, cytosolic II	Mus musculus	64-67
2217212-0	1990	Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.	Arginine	120-128	Rev	Human immunodeficiency virus 1	67-70
2217212-2	1990	A short arginine-rich sequence in Rev contains the signals required to direct this protein into nuclei, where it associates preferentially with nucleoli.	Arginine	8-16	Rev	Human immunodeficiency virus 1	34-37
2232482-6	1990	The pH optimum for cathepsin B (substrate: Z-Arg-Arg-HNMec) and L (substrate: Z-Phe-Arg-HNMec in the presence of Z-Phe-Phe-CHN2) was approximately pH 6.0 for both glomeruli and renal cortex; while that for cathepsin H (substrate: Arg-HNMec) was approximately 6.5.	Arginine	45-48	chimerin 2	Rattus norvegicus	123-127
1695589-5	1990	Infusion of rat galanin reduced unstimulated insulin release (approximately 60%, P less than 0.01) and the insulin responses to arginine (approximately 30%, P less than 0.025), glucose (100%, P less than 0.01), and VIP (approximately 80%, P less than 0.025).	Arginine	128-136	insulin	Sus scrofa	107-114
1695589-8	1990	Pig galanin inhibited the insulin output elicited by arginine (approximately 45%, P less than 0.05) but did not affect the somatostatin and glucagon responses to the aminogenic stimulus.	Arginine	53-61	insulin	Sus scrofa	26-33
1975096-0	1990	Prenatal detection of an Arg----Ter mutation at codon 111 of the PAH gene using DNA amplification.	Arginine	25-28	phenylalanine hydroxylase	Homo sapiens	65-68
1975096-6	1990	The results indicated that the fetal DNA carried a PAH 111 Arg----Ter mutant gene inherited from his father.	Arginine	59-62	phenylalanine hydroxylase	Homo sapiens	51-54
1969838-6	1990	The frequent occurrence of mutations at arginine codons that contain the sequence CGN can be explained by the dramatic elevation of transitions at CpG.	Arginine	40-48	cingulin	Homo sapiens	82-85
2318983-5	1990	This report, based on extensive oligonucleotide dot blot hybridization of PCR-amplified DQA1 and DQB1 genes, reinforces the importance of the Asp57-negative DQ beta chain, but also introduces the possibility that a DQ alpha chain bearing an arginine in position 52 (Arg52) confers susceptibility to IDDM.	Arginine	241-249	major histocompatibility complex, class II, DQ alpha 1	Homo sapiens	88-92
2103832-1	1990	Methyl esters of aromatic a-amino acids, peptides with N-terminal tyrosine and C-terminal arginine, and amides of peptides with N-terminal aromatic amino acids all inhibit monoamine oxidases A and B from rat liver mitochondria with an IC50 of 0.2-3 mM.	Arginine	90-98	monoamine oxidase A	Rattus norvegicus	172-198
2406030-6	1990	We propose that the HIV-1 Rev trans-activator belongs to a new class of sequence-specific RNA binding proteins characterized by the presence of an arginine-rich binding motif.	Arginine	147-155	Rev	Human immunodeficiency virus 1	26-29
2303410-5	1990	Altered cDNAs encoding pro-NPY with -Arg-Arg-, -Arg-Lys-, or Lys-Lys- at the cleavage site were used to generate stable cell lines.	Arginine	37-40	neuropeptide Y	Mus musculus	23-30
2303410-5	1990	Altered cDNAs encoding pro-NPY with -Arg-Arg-, -Arg-Lys-, or Lys-Lys- at the cleavage site were used to generate stable cell lines.	Arginine	41-44	neuropeptide Y	Mus musculus	23-30
2303410-5	1990	Altered cDNAs encoding pro-NPY with -Arg-Arg-, -Arg-Lys-, or Lys-Lys- at the cleavage site were used to generate stable cell lines.	Arginine	41-44	neuropeptide Y	Mus musculus	23-30
2303410-9	1990	Pro-NPY(-Arg-Arg-) was cleaved at a rate similar to that observed for the wild-type pro-NPY(-Lys-Arg-).	Arginine	9-12	neuropeptide Y	Mus musculus	0-7
2303410-9	1990	Pro-NPY(-Arg-Arg-) was cleaved at a rate similar to that observed for the wild-type pro-NPY(-Lys-Arg-).	Arginine	13-16	neuropeptide Y	Mus musculus	0-7
2303410-9	1990	Pro-NPY(-Arg-Arg-) was cleaved at a rate similar to that observed for the wild-type pro-NPY(-Lys-Arg-).	Arginine	13-16	neuropeptide Y	Mus musculus	0-7
2303410-10	1990	In contrast, pro-NPY(-Arg-Lys-) was cleaved at a much lower rate, and pro-NPY (-Lys-Lys-) was cleaved very poorly.	Arginine	22-25	neuropeptide Y	Mus musculus	13-20
2352355-2	1990	GAA is formed from arginine and glycine by glycine-amidinotransferase (GAT) mainly in the kidney.	Arginine	19-27	glycine amidinotransferase	Rattus norvegicus	71-74
1965949-1	1990	The platelet adhesion on adhesive protein-coated surfaces was significantly reduced by the addition of the synthetic tetrapeptide, RGDS (Arg-Gly-Asp-Ser), which was identified as the common amino acid sequence of adhesive site of adhesive proteins.	Arginine	137-140	ral guanine nucleotide dissociation stimulator	Homo sapiens	131-135
2077397-3	1990	An IFN-alpha analogue in which arginine and lysine residues 121 and 122 were replaced by 2 leucines was generated by site-directed in vitro mutagenesis of the IFN-alpha 4 gene; at equivalent concentrations of antiviral activity, this analogue was 10-fold less effective in NK stimulation.	Arginine	31-39	interferon alpha 2	Homo sapiens	3-12
33972717-3	2021	In this study, we found that PRMT5 interacts with KLF5 and catalyzes the di-methylation of KLF5 at Arginine 57 (R57) in a methyltransferase activity-dependent manner in BLBC cells.	Arginine	99-107	Kruppel like factor 5	Homo sapiens	50-54
33972717-3	2021	In this study, we found that PRMT5 interacts with KLF5 and catalyzes the di-methylation of KLF5 at Arginine 57 (R57) in a methyltransferase activity-dependent manner in BLBC cells.	Arginine	99-107	Kruppel like factor 5	Homo sapiens	91-95
33787218-3	2021	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	furin, paired basic amino acid cleaving enzyme	Homo sapiens	4-9
33787218-3	2021	The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1 which accommodates a polybasic stretch ending in a C-terminal arginine.	Arginine	208-216	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	41-46
33232463-0	2021	Single Nucleotide Polymorphisms in the Arginase 1 and 2 Genes Are Differentially Associated with Circulating l-Arginine Concentration in Unsupplemented and l-Arginine-Supplemented Adults.	Arginine	109-119	arginase 1	Homo sapiens	39-55
33232463-0	2021	Single Nucleotide Polymorphisms in the Arginase 1 and 2 Genes Are Differentially Associated with Circulating l-Arginine Concentration in Unsupplemented and l-Arginine-Supplemented Adults.	Arginine	156-166	arginase 1	Homo sapiens	39-55
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	156-166	arginase 1	Homo sapiens	84-94
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	156-166	arginase 1	Homo sapiens	96-100
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	204-214	arginase 1	Homo sapiens	84-94
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	204-214	arginase 1	Homo sapiens	96-100
25963836-11	2015	Multiple simulations of the MUC1-G peptide indicate consistent binding with the thymine loop of the aptamer, initiated by the arginine residue of the peptide.	Arginine	126-134	mucin 1, cell surface associated	Homo sapiens	28-32
20108004-4	2010	The mutation in this patient was identified in exon 12 of CFB and changes a lysine at amino acid position 533 to an arginine (c.1598A&gt;G p.Lys533Arg).	Arginine	116-124	complement factor B	Homo sapiens	58-61
19584108-6	2009	Piwi proteins were found in complex with PRMT5/WDR77, an enzyme that dimethylates arginine residues.	Arginine	82-90	protein arginine N-methyltransferase 5	Mus musculus	41-46
15610009-3	2004	The high-resolution structures of HIV Rev Arg-rich motif (ARM) in complexes with the wild-type RNA and the RNA aptamer reveal that, despite the significantly different RNA sequences, the two complexes share similar structural features and the protein-RNA interactions are mediated mostly by the Arg side chains in Rev ARM.	Arginine	42-45	Rev	Human immunodeficiency virus 1	38-41
15610009-3	2004	The high-resolution structures of HIV Rev Arg-rich motif (ARM) in complexes with the wild-type RNA and the RNA aptamer reveal that, despite the significantly different RNA sequences, the two complexes share similar structural features and the protein-RNA interactions are mediated mostly by the Arg side chains in Rev ARM.	Arginine	42-45	Rev	Human immunodeficiency virus 1	314-317
15610009-3	2004	The high-resolution structures of HIV Rev Arg-rich motif (ARM) in complexes with the wild-type RNA and the RNA aptamer reveal that, despite the significantly different RNA sequences, the two complexes share similar structural features and the protein-RNA interactions are mediated mostly by the Arg side chains in Rev ARM.	Arginine	295-298	Rev	Human immunodeficiency virus 1	38-41
34915016-7	2022	Two ARG types (sulfonamide resistance genes (sul1) and aminoglycoside resistance genes (aadA1, aadA13, and aadA2)) were prevalent in all the processes.	Arginine	4-7	dihydropteroate synthase	Escherichia coli	45-49
34599829-2	2022	Protein arginine methyltransferase 2 (PRMT2) is responsible for methylation of arginine residues on histones and targets transcription factors critically involved in many cellular processes, including gene transcription, mRNA splicing, cell proliferation and differentiation.	Arginine	79-87	protein arginine N-methyltransferase 2	Mus musculus	0-36
34599829-2	2022	Protein arginine methyltransferase 2 (PRMT2) is responsible for methylation of arginine residues on histones and targets transcription factors critically involved in many cellular processes, including gene transcription, mRNA splicing, cell proliferation and differentiation.	Arginine	79-87	protein arginine N-methyltransferase 2	Mus musculus	38-43
34737197-1	2022	Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell cycle regulation, mRNA splicing, cell differentiation, cell signaling, and apoptosis.	Arginine	106-114	protein arginine N-methyltransferase 5	Mus musculus	0-36
34737197-1	2022	Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell cycle regulation, mRNA splicing, cell differentiation, cell signaling, and apoptosis.	Arginine	106-114	protein arginine N-methyltransferase 5	Mus musculus	38-43
34967840-4	2021	We searched online databases using relevant keywords up to April 2021 to identify RCTs using oral L-arginine on systolic (SBP) and diastolic BP (DBP) in adults.	Arginine	98-108	selenium binding protein 1	Homo sapiens	122-125
34967840-9	2021	The pooled analysis demonstrated significant decreases in SBP (WMD = -6.40 mmHg; 95%CI: -8.74, -4.05; P<0.001) and DBP (WMD = -2.64 mmHg; 95%CI: -3.94, -1.40; P<0.001) after L-arginine supplementation.	Arginine	174-184	selenium binding protein 1	Homo sapiens	58-61
34967840-14	2021	In the nonlinear dose-response analysis, the effective dosage of L-arginine supplementation was detected to be >=4 g/day for SBP (P = 0.034) independent of trial duration.	Arginine	65-75	selenium binding protein 1	Homo sapiens	125-128
34944061-0	2021	Differences of Transport Activity of Arginine and Regulation on Neuronal Nitric Oxide Synthase and Oxidative Stress in Amyotrophic Lateral Sclerosis Model Cell Lines.	Arginine	37-45	nitric oxide synthase 1, neuronal	Mus musculus	64-94
34944061-9	2021	Pretreatment with arginine elevated nNOS mRNA levels in MT.	Arginine	18-26	nitric oxide synthase 1, neuronal	Mus musculus	36-40
34913532-7	2022	Further, the arginine mutation causes enhanced DNA bending, enabling the IRF4K59R to interact more robustly with known DNA targets, as evidenced by increased binding affinity of the protein-DNA complex.	Arginine	13-21	interferon regulatory factor 4	Homo sapiens	73-81
34536673-1	2021	Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid-leucine-arginine sequence-contained chemokines CXCs (ELR+ CXCs).	Arginine	70-78	C-X-C motif chemokine receptor 2	Homo sapiens	22-27
34943588-1	2021	Arginase-1 catalyzes the conversion of arginine to ornithine and urea.	Arginine	39-47	arginase 1	Homo sapiens	0-10
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	15-25
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	27-30
34888656-0	2022	Interaction of huntingtin (HTT) with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity.	Arginine	62-70	huntingtin	Homo sapiens	91-94
34888656-3	2022	Arginine methylation/dimethylation is an important modification with an emerging role in neurodegeneration, however arginine methylation of HTT remains largely unexplored.	Arginine	116-124	huntingtin	Homo sapiens	140-143
34888656-4	2022	Here we report nearly two dozen novel arginine methylation/dimethylation sites on the endogenous HTT from human and mouse brain and human cells suggested by mass spectrometry with data-dependent acquisition (DDA).	Arginine	38-46	huntingtin	Homo sapiens	97-100
34866476-2	2021	In our study, a significant relationship was found between the ages of patients, and fear of death, avoidance of death, accepting approach, non-acceptance, and the DAP-R scale total score.	Arginine	168-169	death associated protein	Homo sapiens	164-167
34717959-5	2021	Arginine insertion into membrane proteins can generate water-filled pores in the plasma membrane, and our molecular dynamic (MD) simulations of the principle states of Na+,K+-ATPase transport demonstrated massive water inflow into mutant alpha1, and destabilization of the ion binding sites.	Arginine	0-8	ATPase H+ transporting V0 subunit a1	Homo sapiens	238-244
34717959-6	2021	MD simulations also indicated that a water pathway was created between the mutant arginine residue and the cytoplasm, and analysis of oocytes expressing mutant alpha1 detected a non-specific cation current.	Arginine	82-90	ATPase H+ transporting V0 subunit a1	Homo sapiens	160-166
34536489-1	2021	BACKGROUND: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2, changing the coded amino acid from a glutamine to arginine at the so-called Q/R site, which is critical for regulating calcium permeability.	Arginine	178-186	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	16-21
34536489-1	2021	BACKGROUND: The GluA2 subunit of AMPA receptors (AMPARs) undergoes RNA editing at a specific base mediated by the enzyme ADAR2, changing the coded amino acid from a glutamine to arginine at the so-called Q/R site, which is critical for regulating calcium permeability.	Arginine	178-186	adenosine deaminase RNA specific B1	Homo sapiens	121-126
34753510-8	2021	CONCLUSION: It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.	Arginine	126-127	forkhead box O1	Rattus norvegicus	156-161
34753510-8	2021	CONCLUSION: It is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia.	Arginine	126-127	forkhead box O3	Rattus norvegicus	166-172
34592262-2	2021	One of the most well-studied protein PTMs is methylation, wherein an enzyme catalyzes the transfer of a methyl group from a cofactor to a lysine or arginine side chain.	Arginine	148-156	parathymosin	Homo sapiens	37-41
34518197-1	2021	Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells.	Arginine	18-28	arginase, liver	Mus musculus	49-59
34518197-1	2021	Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells.	Arginine	18-28	arginase, liver	Mus musculus	61-65
34673031-3	2021	Previously, we showed that dephosphorylation of the splicing factor SRSF2 regulated increased interactions with similar arginine-rich RBPs U1-70K and LUC7L3.	Arginine	120-128	serine and arginine rich splicing factor 2	Homo sapiens	68-73
34499080-0	2021	Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine.	Arginine	87-95	C9orf72-SMCR8 complex subunit	Homo sapiens	33-40
34499080-1	2021	Arg (R)-rich dipeptide repeat proteins (DPRs; poly(PR): Pro-Arg and poly(GR): Gly-Arg), encoded by a hexanucleotide expansion in the C9ORF72 gene, induce neurodegeneration in amyotrophic lateral sclerosis (ALS).	Arginine	0-3	C9orf72-SMCR8 complex subunit	Homo sapiens	133-140
34583098-0	2021	Arginine methylation by PRMT2 promotes IFN-beta production through TLR4/IRF3 signaling pathway.	Arginine	0-8	interferon regulatory factor 3	Homo sapiens	72-76
34583098-6	2021	Furthermore, PRMT1, 2 and 3 was recruited to methylate interferon regulatory factor 3 (IRF3) after LPS stimulation respectively, but the effect of PRMT2 on arginine methylation of IRF3 is the most significant among the above three PRMTs.	Arginine	156-164	interferon regulatory factor 3	Homo sapiens	55-85
34583098-6	2021	Furthermore, PRMT1, 2 and 3 was recruited to methylate interferon regulatory factor 3 (IRF3) after LPS stimulation respectively, but the effect of PRMT2 on arginine methylation of IRF3 is the most significant among the above three PRMTs.	Arginine	156-164	interferon regulatory factor 3	Homo sapiens	87-91
34583098-6	2021	Furthermore, PRMT1, 2 and 3 was recruited to methylate interferon regulatory factor 3 (IRF3) after LPS stimulation respectively, but the effect of PRMT2 on arginine methylation of IRF3 is the most significant among the above three PRMTs.	Arginine	156-164	interferon regulatory factor 3	Homo sapiens	180-184
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	0-8	interferon regulatory factor 3	Homo sapiens	119-123
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	40-48	interferon regulatory factor 3	Homo sapiens	64-68
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	40-48	interferon regulatory factor 3	Homo sapiens	119-123
34583098-8	2021	Arginine methylation of IRF3 on R285 induced by LPS led to its dimerization and promoted its translocation from the cytoplasm to the nucleus.	Arginine	0-8	interferon regulatory factor 3	Homo sapiens	24-28
34583098-9	2021	In addition, the enhancement of arginine methylation of TLR4 induced by PRMT1 or 2 increased IRF3 transcription activity with or without LPS treatment, while PRMT2 with histidine 112 glutamine (H112Q) or methionine 115 isoleucine (M115I) mutation and TLR4 with arginine 812 lysine (R812K) mutation decreased it.	Arginine	32-40	interferon regulatory factor 3	Homo sapiens	93-97
34315816-2	2021	Like several of its SR siblings, the SRSF10 protein is composed of an RNA binding domain (RRM) and of arginine and serine-rich auxiliary domains (RS) that guide interactions with other proteins.	Arginine	102-110	serine and arginine rich splicing factor 10	Homo sapiens	37-43
34607466-5	2021	In our malarial mice, liver damage, which releases hepatic arginase-1 (Arg1) into circulation, correlated with plasma arginine depletion.	Arginine	118-126	arginase, liver	Mus musculus	59-69
34607466-13	2021	Specifically, we showed that liver damage in P. chabaudi-infected mice releases hepatic arginase-1 into circulation, where it may deplete plasma arginine, a candidate malaria therapeutic that mitigates vascular stress.	Arginine	145-153	arginase, liver	Mus musculus	88-98
34768908-0	2021	Heparin and Arginine Based Plasmin Nanoformulation for Ischemic Stroke Therapy.	Arginine	12-20	plasminogen	Homo sapiens	27-34
34768908-5	2021	Here in this paper, we report a novel heparin and arginine-based plasmin nanoformulation that exhibits increased plasmin stability and efficacy.	Arginine	50-58	plasminogen	Homo sapiens	65-72
34768908-5	2021	Here in this paper, we report a novel heparin and arginine-based plasmin nanoformulation that exhibits increased plasmin stability and efficacy.	Arginine	50-58	plasminogen	Homo sapiens	113-120
34738012-8	2021	Furthermore, we uncovered that arginine methylation of the CIRBP RG/RGG region regulates in vitro phosphorylation by SRPK1.	Arginine	31-39	SRSF protein kinase 1	Homo sapiens	117-122
34667218-10	2021	We conclude that inflammatory cells in blood and heart consume arginine and probably homoarginine via arginase 1 and inducible NO synthase and release ornithine and citrulline.	Arginine	63-71	arginase 1	Rattus norvegicus	102-112
34105240-2	2021	MATERIALS AND METHODS: In the current study we have exchanged selected amino acids at position 3 and 8 of AVP, namely phenylalanine and arginine, with those of oxytocin to generate novel analogues with altered receptor selectivity.	Arginine	136-144	arginine vasopressin	Mus musculus	106-109
34648414-5	2021	Pooled analysis revealed that the XRCC2 Arg188His polymorphism was associated with increased CRC risk (His versus Arg: OR 1.14, 95% CI 1.01, 1.29).	Arginine	114-117	X-ray repair cross complementing 2	Homo sapiens	34-39
34551290-0	2021	The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation.	Arginine	89-97	TANK-binding kinase 1	Mus musculus	54-58
34551290-7	2021	Our findings reveal insights into the molecular regulation of TBK1 activation and demonstrate the essential function of protein arginine methylation in innate antiviral immunity.	Arginine	128-136	TANK-binding kinase 1	Mus musculus	62-66
34575922-0	2021	Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	24-30
34575922-0	2021	Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells.	Arginine	0-8	DEAD-box helicase 3 X-linked	Homo sapiens	44-48
34575922-0	2021	Arginine Methylation of hnRNPK Inhibits the DDX3-hnRNPK Interaction to Play an Anti-Apoptosis Role in Osteosarcoma Cells.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	49-55
34575922-3	2021	We previously showed that arginine methylation of hnRNPK attenuated the apoptosis of U2OS osteosarcoma cells under DNA damage conditions, whereas the replacement of endogenous hnRNPK with a methylation-defective mutant inversely enhanced apoptosis.	Arginine	26-34	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	50-56
34575922-7	2021	Overall, we have shown that the arginine methylation of hnRNPK suppresses the apoptosis of U2OS cells via interfering with DDX3-hnRNPK interaction.	Arginine	32-40	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	56-62
34575922-7	2021	Overall, we have shown that the arginine methylation of hnRNPK suppresses the apoptosis of U2OS cells via interfering with DDX3-hnRNPK interaction.	Arginine	32-40	DEAD-box helicase 3 X-linked	Homo sapiens	123-127
34575922-7	2021	Overall, we have shown that the arginine methylation of hnRNPK suppresses the apoptosis of U2OS cells via interfering with DDX3-hnRNPK interaction.	Arginine	32-40	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	128-134
34161779-4	2021	Here, we performed biochemical and biophysical analysis on CHD7 chromatin remodeler and uncover that N-terminal to the Chromodomain (N-CRD) interacts with nucleosome and contains a high conserved arginine stretch, which is reminiscent of arginine anchor.	Arginine	196-204	chromodomain helicase DNA binding protein 7	Homo sapiens	59-63
34161779-4	2021	Here, we performed biochemical and biophysical analysis on CHD7 chromatin remodeler and uncover that N-terminal to the Chromodomain (N-CRD) interacts with nucleosome and contains a high conserved arginine stretch, which is reminiscent of arginine anchor.	Arginine	238-246	chromodomain helicase DNA binding protein 7	Homo sapiens	59-63
34448450-1	2021	Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine.	Arginine	116-124	protein arginine N-methyltransferase 5	Mus musculus	0-36
34448450-1	2021	Protein arginine methyltransferase 5 (Prmt5) is the major type II enzyme responsible for symmetric dimethylation of arginine.	Arginine	116-124	protein arginine N-methyltransferase 5	Mus musculus	38-43
34504490-1	2021	Mouse T cells express the ecto-ADP-ribosyltransferase ARTC2.2, which can transfer the ADP-ribose group of extracellular nicotinamide adenine dinucleotide (NAD+) to arginine residues of various cell surface proteins thereby influencing their function.	Arginine	164-172	ADP-ribosyltransferase 2a	Mus musculus	54-59
34400610-5	2021	In SerRS knock-in mice bearing acetylation-defective lysine to arginine mutation, we observed increased body weight and adipose tissue mass.	Arginine	63-71	seryl-aminoacyl-tRNA synthetase 2	Mus musculus	3-8
34132576-6	2021	Mutational and sequence analysis revealed conserved lysine/arginine residues at positions 49/50 and 91 of betaC1 proteins to be essential for their ATPase activity.	Arginine	59-67	dynein axonemal heavy chain 8	Homo sapiens	148-154
34132576-16	2021	The lysine/arginine residues conserved at positions 49 and 91 of betaC1 were found to be crucial for its ATPase function.	Arginine	11-19	dynein axonemal heavy chain 8	Homo sapiens	105-111
34184805-7	2021	Collectively, these findings suggest that TGF-beta and Snail promote arginine synthesis via inhibiting LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly and this complex can serve as potential target for the development of new therapeutic approaches to treat CRC.	Arginine	69-77	transforming growth factor alpha	Homo sapiens	42-50
34284575-0	2021	Comprehensive O-Glycosylation Analysis of the SARS-CoV-2 Spike Protein with Biomimetic Trp-Arg Materials.	Arginine	91-94	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
34381436-7	2021	Hoxa1 mutation decreased the expression of bacterial genes involved in ABC transporters, purine metabolism, and aminoacyl-tRNA biosynthesis and increased the expression of bacterial genes involved in two-component system, starch and sucrose metabolism, and arginine and proline metabolism.	Arginine	257-265	homeobox A1	Sus scrofa	0-5
34292156-0	2021	Retraction: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	12-20	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	36-42
34292156-0	2021	Retraction: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	12-20	protein tyrosine kinase 2	Homo sapiens	121-124
34359992-1	2021	Arginase 1 (ARG1) is a cytosolic enzyme that cleaves L-arginine, the substrate of inducible nitric oxide synthase (iNOS), and thereby impairs the control of various intracellular pathogens.	Arginine	53-63	arginase, liver	Mus musculus	12-16
34359242-4	2021	Without Ce stimulation, increased Met, Arg, or Met + Arg resulted in lower p-mTOR.	Arginine	39-42	mechanistic target of rapamycin kinase	Bos taurus	77-81
34359242-4	2021	Without Ce stimulation, increased Met, Arg, or Met + Arg resulted in lower p-mTOR.	Arginine	53-56	mechanistic target of rapamycin kinase	Bos taurus	77-81
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	mechanistic target of rapamycin kinase	Bos taurus	113-117
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	mechanistic target of rapamycin kinase	Bos taurus	121-125
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	mechanistic target of rapamycin kinase	Bos taurus	132-136
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	AKT serine/threonine kinase 1	Bos taurus	142-145
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	AKT serine/threonine kinase 1	Bos taurus	149-152
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	61-64	AKT serine/threonine kinase 1	Bos taurus	159-162
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	mechanistic target of rapamycin kinase	Bos taurus	113-117
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	mechanistic target of rapamycin kinase	Bos taurus	121-125
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	mechanistic target of rapamycin kinase	Bos taurus	132-136
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	AKT serine/threonine kinase 1	Bos taurus	142-145
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	AKT serine/threonine kinase 1	Bos taurus	149-152
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	75-78	AKT serine/threonine kinase 1	Bos taurus	159-162
34359242-5	2021	Compared with control SAT stimulated with Ce, increased Met, Arg, or Met + Arg resulted in greater activation of mTOR (p-mTOR/total mTOR) and AKT (p-AKT/total AKT), with a more pronounced response due to Arg.	Arginine	204-207	mechanistic target of rapamycin kinase	Bos taurus	121-125
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	H2A.X variant histone	Homo sapiens	81-86
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	MAX dimerization protein 1	Homo sapiens	88-92
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	phospholipase C gamma 2	Homo sapiens	94-99
34118613-9	2021	When using growth rate or FCR as an indicator in broilers, a ratio in the range of 0.77 to 1.3:1 (w:w arginine:GAA) was seen, with one study noting a ratio of 2:1 when using FCR as an indicator.	Arginine	102-110	FCR	Gallus gallus	26-29
34306321-9	2021	Furthermore, inhibiting miR-205 alleviated MI/R-induced apoptosis, reduced infarct size, prevented oxidative stress increase and mitochondrial fragmentation, and improved mitochondrial functional capacity and cardiac function.	Arginine	46-47	microRNA 205	Mus musculus	24-31
34198993-2	2021	Amino acids, especially leucine and arginine, are known to be important activators of mTORC1 and to promote lysosomal translocation of mTORC1, where mTORC1 is thought to make contact with its activator Rheb GTPase.	Arginine	36-44	CREB regulated transcription coactivator 1	Mus musculus	86-92
34198993-2	2021	Amino acids, especially leucine and arginine, are known to be important activators of mTORC1 and to promote lysosomal translocation of mTORC1, where mTORC1 is thought to make contact with its activator Rheb GTPase.	Arginine	36-44	CREB regulated transcription coactivator 1	Mus musculus	135-141
34198993-2	2021	Amino acids, especially leucine and arginine, are known to be important activators of mTORC1 and to promote lysosomal translocation of mTORC1, where mTORC1 is thought to make contact with its activator Rheb GTPase.	Arginine	36-44	CREB regulated transcription coactivator 1	Mus musculus	149-155
34365446-8	2021	The maximum effect on the morphological state of the liver was observed in using a combination of L-arginine and aminoguanidine.	Arginine	98-108	secreted acidic cysteine rich glycoprotein	Mus musculus	19-21
34124017-2	2021	Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes symmetric and asymmetric methylation on arginine residues of histone and non-histone proteins, is overexpressed in many cancers.	Arginine	111-119	protein arginine N-methyltransferase 5	Mus musculus	0-36
34124017-2	2021	Protein arginine methyltransferase 5 (PRMT5), an enzyme that catalyzes symmetric and asymmetric methylation on arginine residues of histone and non-histone proteins, is overexpressed in many cancers.	Arginine	111-119	protein arginine N-methyltransferase 5	Mus musculus	38-43
34268368-1	2021	Background: Protein arginine methyltransferase 5 (PRMT5) catalyzes the methylation of arginine residues in multiple proteins.	Arginine	86-94	protein arginine N-methyltransferase 5	Mus musculus	12-48
34268368-1	2021	Background: Protein arginine methyltransferase 5 (PRMT5) catalyzes the methylation of arginine residues in multiple proteins.	Arginine	86-94	protein arginine N-methyltransferase 5	Mus musculus	50-55
34302694-4	2021	Endogenous NO is produced from L-arginine under catalysis of three isoforms of NOS (eNOS, iNOS, and nNOS).	Arginine	31-41	nitric oxide synthase 1	Homo sapiens	100-104
35504076-6	2022	The umami structures in the six core umami peptides with the lowest binding energy were easy to connect with Ser, Glu, His, Gln, Arg and Lys residues in T1R3 through hydrogen bond and salt bridge.	Arginine	129-132	taste 1 receptor member 3	Homo sapiens	153-157
35183959-3	2022	Amino acid analysis revealed that glutamic acid, aspartic acid, arginine, and leucine were the dominant amino acids lupin protein.	Arginine	64-72	5'-nucleotidase, cytosolic IIIA	Homo sapiens	116-121
35477090-0	2022	FXR/ASS1 axis attenuates the TAA-induced liver injury through arginine metabolism.	Arginine	62-70	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-3
35477090-6	2022	Subsequent studies demonstrated that activation of FXR by its agonist obeticholic acid (OCA) directly promoted ASS1 transcription and enhanced arginine synthesis, leading to the alleviation of TAA-mediated liver injury.	Arginine	143-151	nuclear receptor subfamily 1 group H member 4	Homo sapiens	51-54
35477090-8	2022	Taken together, our study illustrated a protective role of the FXR/ASS1 axis in TAA-induced liver injury by targeting arginine metabolism, which might shed light on the development of novel therapeutic approaches for acute liver injury.	Arginine	118-126	nuclear receptor subfamily 1 group H member 4	Homo sapiens	63-66
35231489-3	2022	NO is produced from L-arginine through the action of the enzyme NO synthase (NOS).	Arginine	20-30	nitric oxide synthase 1 (neuronal)	Danio rerio	64-75
35577075-0	2022	Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1.	Arginine	25-33	CREB regulated transcription coactivator 1	Mus musculus	88-94
35577075-2	2022	mTORC1 activity is regulated by growth factors and amino acids which signal through distinct but integrated molecular pathways: growth factors largely signal through the PI3K/Akt-dependent pathway, whereas the availabilities of amino acids leucine and arginine are communicated to mTORC1 by the Rag-GTPase pathway.	Arginine	252-260	CREB regulated transcription coactivator 1	Mus musculus	0-6
35577075-2	2022	mTORC1 activity is regulated by growth factors and amino acids which signal through distinct but integrated molecular pathways: growth factors largely signal through the PI3K/Akt-dependent pathway, whereas the availabilities of amino acids leucine and arginine are communicated to mTORC1 by the Rag-GTPase pathway.	Arginine	252-260	CREB regulated transcription coactivator 1	Mus musculus	281-287
35577075-3	2022	While it is relatively well described how acute changes in leucine and arginine levels affect mTORC1 signaling, the effects of prolonged amino acid deprivation remain less well understood.	Arginine	71-79	CREB regulated transcription coactivator 1	Mus musculus	94-100
35577075-4	2022	Here, we demonstrate that prolonged deprivation of arginine and/or leucine leads to reactivation of mTORC1 activity, which reaches activation levels similar to those observed in nutrient-rich conditions.	Arginine	51-59	CREB regulated transcription coactivator 1	Mus musculus	100-106
35549865-9	2022	Of interest, restoration of NO by L-arginine may attenuate SARS-CoV-2 infection through different mechanisms, including reduction binding of SARS-CoV-2 to ACE2, inhibition of transmembrane protease serine type 2 (TMPRSS2) a critical for activation of SARS-CoV-2 spike protein and cellular entry, inhibition proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy.	Arginine	34-44	angiotensin converting enzyme 2	Homo sapiens	155-159
35549865-9	2022	Of interest, restoration of NO by L-arginine may attenuate SARS-CoV-2 infection through different mechanisms, including reduction binding of SARS-CoV-2 to ACE2, inhibition of transmembrane protease serine type 2 (TMPRSS2) a critical for activation of SARS-CoV-2 spike protein and cellular entry, inhibition proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy.	Arginine	34-44	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	262-267
35316752-2	2022	Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and played crucial roles in the regulation of tumor growth and metastasis through various mechanisms such as regulating L-arginine metabolism, influencing tumor immune microenvironment, etc.	Arginine	313-323	arginase 1	Homo sapiens	76-105
35316752-2	2022	Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and played crucial roles in the regulation of tumor growth and metastasis through various mechanisms such as regulating L-arginine metabolism, influencing tumor immune microenvironment, etc.	Arginine	313-323	arginase 1	Homo sapiens	107-111
35477757-5	2022	SMARCA4 recognizes the H2A-H2B acidic pocket of the nucleosome through three arginine anchors of the Snf2 ATP coupling (SnAc) domain.	Arginine	77-85	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	0-7
35477757-5	2022	SMARCA4 recognizes the H2A-H2B acidic pocket of the nucleosome through three arginine anchors of the Snf2 ATP coupling (SnAc) domain.	Arginine	77-85	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	101-105
35437830-5	2022	Dobutamine plasma concentration and exposure time respective HR (adjusted to gestational age) is dependent on beta1-AR Arg389Gly polymorphism so that in G/G (Gly) homozygotes and G/C heterozygotes dobutamine increases HR more than in C/C (Arg) homozygotes, with parameter estimate (95% CI) of 38.3 (15.8 - 60.7) bpm per AUC of 100 mug L-1 h, p=0.0008.	Arginine	239-242	adrenoceptor beta 1	Homo sapiens	110-118
35291874-1	2022	Guanidinoacetic acid (GAA) is a natural amino acid derivative involved in several metabolic pathways across the human body, including creatine biosynthesis, arginine utilization, and neuromodulation.	Arginine	157-165	alpha glucosidase	Homo sapiens	22-25
35291874-2	2022	Apart from GAA synthesized internally from glycine and arginine, a total daily exposure to GAA also involves exogenous dietary sources.	Arginine	55-63	alpha glucosidase	Homo sapiens	11-14
35291874-2	2022	Apart from GAA synthesized internally from glycine and arginine, a total daily exposure to GAA also involves exogenous dietary sources.	Arginine	55-63	alpha glucosidase	Homo sapiens	91-94
35409362-0	2022	Protein Kinase C (Pkc)-delta Mediates Arginine-Induced Glucagon Secretion in Pancreatic alpha-Cells.	Arginine	38-46	glucagon	Mus musculus	55-63
35409362-10	2022	Moreover, arginine-induced glucagon secretions were decreased in alphaPkcdeltaKO mice and islets from alphaPkcdeltaKO mice.	Arginine	10-18	glucagon	Mus musculus	27-35
35409362-11	2022	Pkcdelta is essential for arginine-induced glucagon secretion in pancreatic alpha-cells.	Arginine	26-34	glucagon	Mus musculus	43-51
35124444-1	2022	Guanidinoacetic acid (GAA) is the direct precursor of creatine and can spare arginine (Arg) for creatine synthesis in low crude protein (CP) broiler diets.	Arginine	77-85	alpha glucosidase	Homo sapiens	22-25
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Arginine	85-93	C9orf72-SMCR8 complex subunit	Homo sapiens	69-76
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Arginine	165-173	C9orf72-SMCR8 complex subunit	Homo sapiens	69-76
35448460-0	2022	L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact.	Arginine	0-10	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	97-101
35448460-0	2022	L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact.	Arginine	0-10	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	102-106
35448460-0	2022	L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact.	Arginine	28-36	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	97-101
35448460-0	2022	L-Arginine and Cardioactive Arginine Derivatives as Substrates and Inhibitors of Human and Mouse NaCT/Nact.	Arginine	28-36	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	102-106
35448460-6	2022	Arginine and the derivatives ADMA and L-homoarginine were identified as substrates of human and mouse NaCT.	Arginine	0-8	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	102-106
35448460-7	2022	Transport of arginine and derivatives mediated by human and mouse NaCT were dose-dependently inhibited by SDMA.	Arginine	13-21	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	66-70
35448460-8	2022	Whereas BI01383298 inhibited only human NaCT-mediated citrate uptake, it inhibits the uptake of arginine and derivatives mediated by both human NaCT and mouse Nact.	Arginine	96-104	solute carrier family 13 (sodium-dependent citrate transporter), member 5	Mus musculus	159-163
35384117-7	2022	However, two distinct neuronal populations of the medio-basal hypothalamus, which express the (Arg)(Phe)-amide peptides kisspeptin and RFamide-related peptide-3, appear to be well-positioned to relay this seasonal T3 message towards GnRH neurons.	Arginine	95-98	gonadotropin releasing hormone 1	Homo sapiens	233-237
35100360-8	2022	We further identify a physical interaction between ZNF507 and PRMT5, suggesting ZNF507 may target arginine methylation activity to LINE-1 sequences.	Arginine	98-106	zinc finger protein 507	Homo sapiens	51-57
35100360-8	2022	We further identify a physical interaction between ZNF507 and PRMT5, suggesting ZNF507 may target arginine methylation activity to LINE-1 sequences.	Arginine	98-106	zinc finger protein 507	Homo sapiens	80-86
35300428-7	2022	A five ARG-based signature, including A2M, CHEK2, ELN, FOS, and PLAU, was constructed in the TCGA dataset, and stratified patients into low- and high-risk groups with significantly different overall survival (OS) rates.	Arginine	7-10	checkpoint kinase 2	Homo sapiens	43-48
35295316-12	2022	HS increases the expression of the cytosolic arginine sensor for mTORC1 subunits 1 and 2, phosphorylation of mammalian target of rapamycin and decreases the phosphorylation of Janus kinase-2 (a signal transducer and activator of transcription factor-5).	Arginine	45-53	Janus kinase 2	Homo sapiens	176-190
35154362-5	2022	Defensins are antimicrobial peptides that can hypothetically inhibit furin because of their arginine-rich structure.	Arginine	92-100	furin, paired basic amino acid cleaving enzyme	Homo sapiens	69-74
35185887-3	2022	Unlike other KIR receptors, KIR2DL4 contains both an arginine-tyrosine activation motif in its transmembrane region and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail, suggesting that KIR2DL4 may function as an activating or inhibitory receptor.	Arginine	53-61	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	28-35
34313252-9	2022	After the inhibition of SDC-1 shedding by GM6001, SDC-1 and Na+/k+-ATPase-alpha1 expression was restored, while H/R-induced apoptosis was decreased.	Arginine	114-115	syndecan 1	Homo sapiens	24-29
35050625-4	2022	The effect of Arg in the LLPS is subtle, and that of Ubi is concentration dependent.	Arginine	14-17	ubiquitin	Bos taurus	53-56
35061678-9	2022	Combined SNP analysis revealed that the individuals with RAD51-C/C, XRCC2-Arg/Arg, and XRCC3-Thr/Thr genotype combination have three-fold increased BC risk.	Arginine	74-77	X-ray repair cross complementing 2	Homo sapiens	68-73
35061678-9	2022	Combined SNP analysis revealed that the individuals with RAD51-C/C, XRCC2-Arg/Arg, and XRCC3-Thr/Thr genotype combination have three-fold increased BC risk.	Arginine	78-81	X-ray repair cross complementing 2	Homo sapiens	68-73
35203413-4	2022	METHODS: To accomplish systemic L-arginine depletion, repetitive injections of recombinant arginase-1 (rArg-I) were performed.	Arginine	32-42	arginase 1	Homo sapiens	91-101
35162963-5	2022	In the WT mice, the proliferative activity in the HA binding peptide-OPN mimic peptide fusion coated group was significantly higher than that in the control group from day 3 to week 1, and the rates of OPN deposition and direct osteogenesis around the implant surface significantly increased in the recombinant-mouse-OPN (rOPN) group compared to the Gly-Arg-Gly-Asp-Ser peptide group in week 2.	Arginine	354-357	secreted phosphoprotein 1	Mus musculus	69-72
35432786-6	2022	Additionally, semi-stable docking of bisartans at the arginine-rich furin-cleavage site of the SARS-CoV-2 spike protein (residues 681-686) required for virus entry into host cells, suggest bisartans may inhibit furin action thereby retarding viral entry into host cells.	Arginine	54-62	furin, paired basic amino acid cleaving enzyme	Homo sapiens	68-73
35432786-6	2022	Additionally, semi-stable docking of bisartans at the arginine-rich furin-cleavage site of the SARS-CoV-2 spike protein (residues 681-686) required for virus entry into host cells, suggest bisartans may inhibit furin action thereby retarding viral entry into host cells.	Arginine	54-62	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	106-111
2509460-9	1989	Cotransfection with the eIF-4D arginine variant caused no effect on dihydrofolate reductase synthesis, in agreement with the in vitro experiments.	Arginine	31-39	eukaryotic translation initiation factor 5A	Homo sapiens	24-30
2633825-1	1989	It has been found out that tripeptide Arg-Gly-Asp being under natural conditions a fibronectin fragment, responsible for adhesion, is capable in vitro to stimulate ingestion ability of the rat blood polymorphonuclear leucocytes and monocytes.	Arginine	38-41	fibronectin 1	Rattus norvegicus	83-94
2806726-3	1989	In contrast, monoclonal antibodies directed against the collagen- and integrin-binding domains of fibronectin, or oligopeptides containing the fibronectin integrin-recognition sequence arg-gly-asp-ser, had no significant effect on condensation number.	Arginine	185-188	fibronectin 1	Gallus gallus	143-154
2677400-9	1989	An arginine to threonine mutation at gp120 amino acid 518, the terminal residue of gp120, abolishes both gp160 cleavage and syncytium formation.	Arginine	3-11	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	37-42
2677400-9	1989	An arginine to threonine mutation at gp120 amino acid 518, the terminal residue of gp120, abolishes both gp160 cleavage and syncytium formation.	Arginine	3-11	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	83-88
2689869-0	1989	Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae.	Arginine	0-8	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	113-117
2689869-0	1989	Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae.	Arginine	0-8	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2	Saccharomyces cerevisiae S288C	123-127
2689869-5	1989	Arginine deprivation imposed by PALO also caused increased expression of CPA1 and CPA2, coding respectively for the small and large subunits of arginine-specific carbamyl-phosphate synthetase.	Arginine	0-8	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	73-77
2689869-5	1989	Arginine deprivation imposed by PALO also caused increased expression of CPA1 and CPA2, coding respectively for the small and large subunits of arginine-specific carbamyl-phosphate synthetase.	Arginine	0-8	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2	Saccharomyces cerevisiae S288C	82-86
2689869-6	1989	The observed increase was GCN4 dependent and was genetically separable from arginine-specific repression of CPA1 mRNA translation.	Arginine	76-84	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	108-112
2689869-10	1989	The addition of arginine to strains containing the CPA1-lacZ fusion further reduced beta-galactosidase activity of the gcn4 mutant, indicating independent regulation of the CPA1 gene by the general amino acid control and by arginine-specific repression.	Arginine	16-24	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	51-55
2490997-2	1989	EDRF is identical with nitric oxide (NO), and, under physiological conditions is synthesized in the body from l-arginine.	Arginine	110-120	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
2694588-5	1989	Slower migration of p27rex, corresponding to a 27-kD protein, in NaDodSO4-PAGE when compared with the calculated molecular weight from the amino acid sequence (Mr = 20,367) is suggested to be caused not by post-translational modification, but by the intrinsic nature of the protein, which is rich in proline and arginine.	Arginine	312-320	interferon alpha inducible protein 27	Homo sapiens	20-23
2512184-0	1989	[Immunoreactive 7B2 concentrations in plasma and cerebrospinal fluid in pathophysiological conditions and the responses to oral glucose load, intravenous LH-RH, TRH and arginine infusion].	Arginine	169-177	secretogranin V	Homo sapiens	16-19
2477372-11	1989	The homologous sequence in the chicken EGF receptor, which binds mouse EGF with a 100-fold lower affinity than the human EGF receptor, contains four amino acid differences including two in the Arg-Gly-Asp-Ser tetramer.	Arginine	193-196	epidermal growth factor	Mus musculus	39-42
2692595-4	1989	Limited proteolysis with thrombin resulted in the cleavage of only a single peptide bond between arginine-132 and alanine-133 in bovine somatotropin dimer.	Arginine	97-105	somatotropin	Bos taurus	136-148
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Arginine	114-122	carboxypeptidase E	Homo sapiens	31-49
2526198-1	1989	A hypothesis was examined that carboxypeptidase H (CpAse H), which is known to catalyse the release of lysine and arginine from the C-terminus of peptides, can also release histidine, tyrosine, and phenylalanine.	Arginine	114-122	carboxypeptidase E	Homo sapiens	51-58
2741942-3	1989	This mutation generates a stop codon, in place of Arg, at amino acid 109 of the mature OTC protein.	Arginine	50-53	ornithine transcarbamylase	Homo sapiens	87-90
2502202-7	1989	A model of the antibody combining site suggests that arginine 24 and arginine 30 in the light chain (CDR1) interact with a surface defined by phosphate or sulfate groups of the antigen.	Arginine	53-61	cerebellar degeneration related protein 1	Homo sapiens	101-105
2813554-9	1989	Both L-arginine and L-proline, the two amino acids component of kentsin, decreased the specific activity of rat liver mitochondrial aldehyde dehydrogenase in vitro at 10(-3) mol concentration.	Arginine	5-15	aldehyde dehydrogenase 2 family member	Rattus norvegicus	118-154
2712576-15	1989	High concentrations of phosphate with magnesium were found to protect enzyme activity when PEPC, previously shown to contain an essential arginine at the active site, was incubated with the specific arginyl reagent 2,3-butanedione, consistent with the binding of phosphate at the active site.	Arginine	138-146	phosphoenolpyruvate carboxykinase 1	Homo sapiens	91-95
2703483-2	1989	This arginine reacts rapidly with [14C]phenylglyoxal, and its reaction is selectively blocked by the presence of either the substrate Met5-enkephalin, the competitive inhibitor phenylalanylalanine, or the transition state analog phosphoramidon.	Arginine	5-13	proenkephalin	Rattus norvegicus	139-149
2471068-1	1989	We have generated deletion mutants of the H-ras p21 protein which lack residues 58 to 63 or 64 to 68 and contain either the normal glycine or an activating mutation, arginine, at position 12.	Arginine	166-174	HRas proto-oncogene, GTPase	Homo sapiens	42-47
2471068-1	1989	We have generated deletion mutants of the H-ras p21 protein which lack residues 58 to 63 or 64 to 68 and contain either the normal glycine or an activating mutation, arginine, at position 12.	Arginine	166-174	H3 histone pseudogene 16	Homo sapiens	48-51
2538756-4	1989	The longer C-terminal extension protein (CEP80) is 30% lysine and arginine and, when denatured, behaves like a small cationic protein.	Arginine	66-74	ribosomal protein S27a	Homo sapiens	41-46
2784439-9	1989	These data suggest that the expression of integrin alpha subunits can be regulated differentially and independently of the beta subunit and that the VLA-1 heterodimer has an important function in mediating Arg-Gly-Asp-dependent cell adhesion or other phenotypic properties in human neuroblastoma cells.	Arginine	206-209	integrin subunit alpha 1	Homo sapiens	149-154
2521835-6	1989	These cells are able to adhere to fibronectin-coated dishes by a mechanism that is inhibitable by a synthetic hexapeptide containing the arg-gly-asp cell recognition sequence of fibronectin.	Arginine	137-140	fibronectin 1	Rattus norvegicus	34-45
2521835-6	1989	These cells are able to adhere to fibronectin-coated dishes by a mechanism that is inhibitable by a synthetic hexapeptide containing the arg-gly-asp cell recognition sequence of fibronectin.	Arginine	137-140	fibronectin 1	Rattus norvegicus	178-189
2912694-10	1989	Competition experiments with various histones (H1, H2A, H2B, H3, and H4) indicated that ASTP bound to the arginine-rich histones H3 and H4, with preference for H4.	Arginine	106-114	glycerol kinase	Rattus norvegicus	88-92
2463329-5	1989	Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide.	Arginine	65-68	vimentin	Homo sapiens	32-40
2463329-5	1989	Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide.	Arginine	73-76	vimentin	Homo sapiens	32-40
2492273-0	1989	A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV.	Arginine	125-133	adrenoceptor alpha 1D	Homo sapiens	70-113
2699145-8	1989	Investigations of the two teams suggested that decapeptide containing arginine on place 8 was the physiological Gn-RH of mammals.	Arginine	70-78	Progonadoliberin-1	Ovis aries	112-117
2698313-4	1989	The cDNA sequence indicated the presence of a Gly-Arg-Gly-Asp-Ser- (GRGDS) amino acid sequence identical to a cell binding sequence in fibronectin, and suggested that osteopontin might function as a cell attachment factor.	Arginine	50-53	secreted phosphoprotein 1	Homo sapiens	167-178
2461903-4	1989	Two amino acid residues of HLA-A29.1, gln-144 and arg-151, were found in all 24 HLA-B and HLA-C alleles examined but were present in only one of 15 HLA-A alleles for which sequence data are available.	Arginine	50-53	major histocompatibility complex, class I, B	Homo sapiens	80-85
2461903-8	1989	These observations are consistent with the notion that gln-144 and arg-151 define a determinant common to HLA-B, HLA-C, and the HLA-Aw19 cross-reactive group and the binding site of the monoclonal antibody 4E.	Arginine	67-70	major histocompatibility complex, class I, B	Homo sapiens	106-111
2788339-5	1989	Increased levels of C4a des Arg have been revealed in 50% of the examinees.	Arginine	28-31	complement C4A (Rodgers blood group)	Homo sapiens	20-23
2788339-7	1989	C4a des Arg has been related to the severity of the skin inflammation and did not depend on the serum IgE content.	Arginine	8-11	complement C4A (Rodgers blood group)	Homo sapiens	0-3
3242846-7	1988	The CPA of GNCP preparation was not blocked by the antiserum and scarcely inhibited in the presence of the synthetic cell attachment-promoting peptide Gly-Arg-Gly-Asp-Ser-Pro, a competitive inhibitor of fibronectin.	Arginine	155-158	fibronectin 1	Mus musculus	203-214
2972888-3	1988	In protein-depleted A/J mice (n = 340) bearing either an immunogenic (C1300) or poorly immunogenic (TBJ) neuroblastoma, arginine supplementation [1%] significantly augmented T lymphocyte responses (mitogenesis, interleukin-2 production) compared with both a glycine-supplemented and nonsupplemented group.	Arginine	120-128	interleukin 2	Mus musculus	211-224
2851659-6	1988	The mutated phenotype that commutes the expression of the two isocytochrome structural genes (superactivation of CYP3 and inhibition of CYC1) results from a transversion in an AGT codon (serine) in the wild-type to an AGG codon (arginine) in the mutant.	Arginine	229-237	cytochrome c isoform 1	Saccharomyces cerevisiae S288C	136-140
3068267-2	1988	Responses of plasma somatotropin and insulin to arginine were measured at 6 and 15 wk postpartum.	Arginine	48-56	insulin	Bos taurus	37-44
3241126-8	1988	Human apoB arginine-3,359 corresponds to a critical arginine (position 142) residue in the apoE LDL receptor binding domain.	Arginine	11-19	low density lipoprotein receptor	Homo sapiens	96-108
2971652-1	1988	Nuclear magnetic resonance studies have revealed the importance of arginine residues in the actin-myosin interface (Moir, A. J. G., and Levine, B.	Arginine	67-75	myosin heavy chain 14	Homo sapiens	98-104
2971652-12	1988	In accordance with the amino acid sequence of each protein this also implies that the actin-myosin interaction involves arginine residues located either after residue 28 of the N-terminal part of actin, since this actin region is devoid of arginine residues, or in the N-terminal portion of the 50-kDa domain, i.e. between residues 239 and 455.	Arginine	120-128	myosin heavy chain 14	Homo sapiens	92-98
2971652-12	1988	In accordance with the amino acid sequence of each protein this also implies that the actin-myosin interaction involves arginine residues located either after residue 28 of the N-terminal part of actin, since this actin region is devoid of arginine residues, or in the N-terminal portion of the 50-kDa domain, i.e. between residues 239 and 455.	Arginine	240-248	myosin heavy chain 14	Homo sapiens	92-98
2972538-8	1988	Furthermore, deletion of the second amino acid, an arginine, resulted in a stable E1A protein.	Arginine	51-59	macrophage stimulating 1 S homeolog	Xenopus laevis	82-85
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Arginine	156-166	interferon gamma	Rattus norvegicus	30-40
3142779-4	1988	rIFN-gamma plus MDP induced the L-arginine-dependent effector mechanism in murine macrophages.	Arginine	32-42	interferon gamma	Rattus norvegicus	0-10
3142779-6	1988	This result indicates that endogenously produced TNF is involved in the induction of the L-arginine-dependent effector mechanism when MDP is the co-stimulant with rIFN-gamma.	Arginine	89-99	interferon gamma	Rattus norvegicus	163-173
3066243-6	1988	A synthetic peptide Gly-Arg-Gly-Asp-Ser, representing the host cell attachment site of fibronectin, partially inhibited the binding of fibronectin and of its 210 kD fragment to S dysgalactiae, but not to S equi.	Arginine	24-27	fibronectin 1	Bos taurus	87-98
3191114-7	1988	Proline-407 is located 14 amino acids C-terminal to the reactive site arginine of ATIII in a core region of the molecule that has been highly conserved during evolution of the serine protease inhibitor (serpin) gene family.	Arginine	70-78	serpin family C member 1	Homo sapiens	82-87
3138980-1	1988	Role of disulphide groups and arginine residues in the concanavalin A-diamine oxidase interaction.	Arginine	30-38	amine oxidase copper containing 1	Sus scrofa	70-85
3292407-9	1988	Optimal chemotactic concentrations of partially purified MNC-derived NCF were of comparable potency to FMLP and LTB4 and had about 60% of the activity of optimal concentrations of C5a, C5a-des-Arg and platelet-activating factor (PAF).	Arginine	193-196	neutrophil cytosolic factor 4	Homo sapiens	69-72
3259239-11	1988	Both intact 125I-EGF, and 125I-EGF lacking the carboxyl terminal arginine were released from chloroquine-treated cells in a ratio equal to that present in the intact cells.	Arginine	65-73	epidermal growth factor	Homo sapiens	31-34
3286698-1	1988	Holstein cows just past peak lactation were used in a 3 x 3 Latin square design to determine the effects of arginine infusion on concentrations of somatotropin and insulin in plasma, milk production, and milk composition.	Arginine	108-116	somatotropin	Bos taurus	147-159
3286698-1	1988	Holstein cows just past peak lactation were used in a 3 x 3 Latin square design to determine the effects of arginine infusion on concentrations of somatotropin and insulin in plasma, milk production, and milk composition.	Arginine	108-116	insulin	Bos taurus	164-171
3286698-6	1988	Injection of arginine into the jugular vein increased concentrations of somatotropin and insulin in plasma, but the increase did not persist for more than 30 min.	Arginine	13-21	somatotropin	Bos taurus	72-84
3286698-6	1988	Injection of arginine into the jugular vein increased concentrations of somatotropin and insulin in plasma, but the increase did not persist for more than 30 min.	Arginine	13-21	insulin	Bos taurus	89-96
3343338-1	1988	The experimental metastasis of B16-F10 murine melanoma cells is blocked by the anti-cell adhesive pentapeptide Gly-Arg-Gly-Asp-Ser (GRGDS) derived from the central cell-binding domain of fibronectin.	Arginine	115-118	fibronectin 1	Mus musculus	187-198
2897249-0	1988	Arginine repression of the Saccharomyces cerevisiae ARG1 gene.	Arginine	0-8	argininosuccinate synthase	Saccharomyces cerevisiae S288C	52-56
2897249-4	1988	Northern blot hybridizations showed that whereas arginine-specific repression reduced the enzyme activity fivefold, it did not reduce the steady state level of the corresponding messenger in proportion; by analogy with the coregulated ARG3 gene, this result suggests a post-transcriptional regulatory mechanism.	Arginine	49-57	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	235-239
2450765-1	1988	The contractile response to substance P (SP), neurokinin A (NKA) and arginin-neurokinin B (Arg-NKB) (a water soluble analogue of NKB) was investigated in detrusor muscle strips from the dome of the urinary bladder obtained from patients undergoing total cystectomy for carcinoma of the bladder base.	Arginine	91-94	tachykinin precursor 3	Homo sapiens	95-98
2450765-3	1988	All neurokinins induced a concentration-related contraction with sensitivity at nM concentrations and the following rank order of potency: NKA (90) greater than Arg-NKB (22) greater than SP (1).	Arginine	161-164	tachykinin precursor 3	Homo sapiens	165-168
3687941-4	1987	In contrast, the Db and PIF proteins are proteolytically cut at Arg 106 and show a double-banded phenotype.	Arginine	64-67	PIF1 5'-to-3' DNA helicase	Homo sapiens	24-27
3688881-4	1987	Kapp, the second-order rate constant of enzyme inactivation by Z-Phe-Phe-CHN2 with LE as substrate was 31,530 M-1 s-1 or 10(3) higher than its effect on cathepsin B-mediated hydrolysis of ME-Arg-Phe at the Met-Arg site.	Arginine	191-194	cathepsin B	Rattus norvegicus	153-164
3688881-5	1987	Gly-Gly cleavage by cathepsin L was blocked by D-Ala2, did not require the presence of free end groups, and was the only site recognized within opioid peptides having a C-terminal Arg-COOH.	Arginine	180-183	cathepsin L	Rattus norvegicus	20-31
2887428-0	1987	Phenylglyoxal modification of arginines in mammalian D-amino-acid oxidase.	Arginine	30-39	D-amino acid oxidase	Homo sapiens	53-73
2887428-1	1987	The presence of arginine in the active center of D-amino-acid oxidase is well documented although its role has been differently interpreted as being part of the substrate-binding site or the positively charged residue near the N1-C2 = O locus of the flavin coenzyme.	Arginine	16-24	D-amino acid oxidase	Homo sapiens	49-69
3305015-9	1987	259, 939-941], the heparin-binding site of antithrombin III has been suggested to be in the region of Pro-41, Arg-47 and Trp-49.	Arginine	110-113	serpin family C member 1	Homo sapiens	43-59
3494079-3	1987	The results from these studies indicate that leu-pro-pro-ser-arg (residues 351 to 355) retained the B cell differentiation-inducing properties of p23; however, expression of activity by this sequence was markedly influenced by N-flanking sequences.	Arginine	61-64	prostaglandin E synthase 3	Mus musculus	146-149
3494079-7	1987	These data indicate that although the leu-pro-pro-ser-arg sequence is able to provide both required signals for p23-induced Ig secretion in spleen cell cultures, there may be subtle differences in how the cell types involved in this response interact with and/or are activated by this sequence.	Arginine	54-57	prostaglandin E synthase 3	Mus musculus	112-115
3109687-6	1987	The Met-enkephalin-Arg-Gly-Leu levels are affected by VPA administration in a more complex pattern.	Arginine	19-22	proenkephalin	Rattus norvegicus	8-18
2442578-0	1987	[A case of association of Hb C Ziguinchor (alpha A2 beta 6-2 (A3) Glu replaced by Val beta 58 (E2) Pro replaced by Arg) with a hereditary persistence of fetal hemoglobin (HPFH).	Arginine	115-118	HBFQTL2	Homo sapiens	171-175
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Arginine	297-300	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	109-114
2950119-0	1987	The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading.	Arginine	41-44	fibronectin 1	Mus musculus	4-15
3590176-4	1987	On the other hand, plasma and CSF concentrations of arginine were not so well controlled.	Arginine	52-60	colony stimulating factor 2	Homo sapiens	30-33
3805128-4	1987	For fibronectin, Gly-Arg-Gly-Asp-Ser was considerably more active than Arg-Gly-Asp-Ser, whereas these two peptides displayed little difference in activity in inhibiting cell adhesion to spreading factor.	Arginine	21-24	fibronectin 1	Gallus gallus	4-15
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	Arginine	96-99	interleukin 1 alpha	Homo sapiens	0-13
3532812-2	1986	Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin.	Arginine	96-99	interleukin 1 alpha	Homo sapiens	15-19
2942550-8	1986	Finally, the tetrapeptide Arg-Gly-Asp-Ser, which corresponds to the fibronectin sequence recognized by fibroblastic cells, specifically and competitively inhibited attachment of hemopoietic cells to this molecule.	Arginine	26-29	fibronectin 1	Mus musculus	68-79
3729426-1	1986	1H-NMR spectra for the angiotensin agonist sarcosine-(Sar)Arg-Val-Tyr-Ile-His-Sar-Phe [( Sar1,Sar7]Ang II) and the antagonist Sar-Arg-Val-Tyr-Ile-His-Sar-Ile in dimethylsulfoxide-d6 were examined at 400 MHz.	Arginine	58-61	secretion associated Ras related GTPase 1A	Homo sapiens	89-105
2423274-2	1986	Arginine (0.5 g/kg body weight infused over 30 min) resulted in transient highly significant increases in urinary albumin (p less than 0.001), beta 2-microglobulin (p less than 0.001) and N-acetyl-beta-D-glucosaminidase [NAG] (p less than 0.001).	Arginine	0-8	beta-2-microglobulin	Homo sapiens	143-163
3082364-0	1986	Chemical modification of lysine and arginine residues in the myosin regulatory light chain inhibits phosphorylation.	Arginine	36-44	myosin heavy chain 14	Homo sapiens	61-67
3516014-4	1986	A comparison of two consecutive sections, each of which was processed for the immunostaining with anti-NPY and anti-Met-Enk-Arg-Gly-Leu antisera, respectively, indicated that NPY and preproenkephalin A and its derivatives coexist in approximately one-fifth of the total NPY-immunoreactive cells.	Arginine	124-127	proenkephalin	Rattus norvegicus	120-123
3080419-6	1986	This substitution is close to an Arg (residue 47) and a Trp (residue 49) which have previously been shown to be critical for heparin binding by antithrombin III.	Arginine	33-36	serpin family C member 1	Homo sapiens	144-160
3863104-4	1985	Arginine-modified heparin cofactor II showed a comparable percentage loss of both antichymotrypsin and antithrombin activities.	Arginine	0-8	serpin family C member 1	Homo sapiens	103-115
2863142-7	1985	The results suggested essential tryptophan, lysine and histidine residues at a common catalytic site for pseudocholinesterase and aryl acylamidase and an arginine residue (or residues) exclusively for pseudocholinesterase.	Arginine	154-162	butyrylcholinesterase	Homo sapiens	201-221
3899686-4	1985	Hepatocytes in arginine-deficient or arginine-containing medium synthesized fibronectin (Fn) over several days at a constant rate of 3 micrograms +/- 1 microgram/mg cell protein per day, with fibronectin representing approximately 3% of the total secreted hepatocyte proteins during any culture period after the first 24 h. Pulse-chase experiments indicated that Fn synthesis and secretion was relatively rapid (t1/2 = 45 min) and represented approximately 95% of the intracellularly labelled Fn.	Arginine	15-23	fibronectin 1	Gallus gallus	76-87
4044659-6	1985	None of these four peptides contains the tetrapeptide sequence Arg-Gly-Asp-Ser, which has been associated with fibronectin-mediated cell adhesion.	Arginine	63-66	fibronectin 1	Rattus norvegicus	111-122
4052027-3	1985	The ability to inhibit ODC appeared to correlate with the arginine-residue content of basic polypeptides.	Arginine	58-66	ornithine decarboxylase 1	Rattus norvegicus	23-26
4030949-9	1985	Comparison of the peptide maps between a single-chain and a degraded form of ceruloplasmin facilitated the identification of two tryptic peptides, derived from the carboxyl-terminal regions of 67 kDa and 50 kDa fragments of the degraded form, which lack the carboxyl-terminal arginine and lysine residues, respectively.	Arginine	276-284	ceruloplasmin	Homo sapiens	77-90
3897912-6	1985	The Met-Enk-Arg-Gly-Leu-like immunoreactivity demonstrated in this study suggests the occurrence of preproenkephalin A and related opioid peptides.	Arginine	12-15	proenkephalin	Rattus norvegicus	8-11
3973902-4	1985	X-ray crystallographic studies of E. coli DHFR in binary complexes with TMP and two members of this acid-containing series of compounds defined the binding of these inhibitors and showed the carboxyl group of the latter two inhibitors to be ionically bound to Arg-57.	Arginine	260-263	Dihydrofolate reductase	Escherichia coli	42-46
2985098-5	1985	Determination of the partial amino-acid sequence by automated Edman degradation of the labelled prepro- and proforms of apo AII led to the segmentation of the N-terminus of the primary translation product, consisting of 23 amino acid residues, into the pre-sequence (18 residues) and the pro-sequence (5 residues) with terminal Arg-Arg-residues at the cleavage site to apo AII.	Arginine	328-331	apolipoprotein A2	Homo sapiens	120-127
2985098-5	1985	Determination of the partial amino-acid sequence by automated Edman degradation of the labelled prepro- and proforms of apo AII led to the segmentation of the N-terminus of the primary translation product, consisting of 23 amino acid residues, into the pre-sequence (18 residues) and the pro-sequence (5 residues) with terminal Arg-Arg-residues at the cleavage site to apo AII.	Arginine	332-335	apolipoprotein A2	Homo sapiens	120-127
3913581-5	1985	Similar experiments were attempted with high molecular weight epidermal growth factor (HMW-EGF), an analogous growth factor complex that can experience a single modification, the release of arginine by carboxypeptidase B from the carboxy terminus of its biological subunit, low molecular weight EGF (LMW-EGF).	Arginine	190-198	epidermal growth factor	Homo sapiens	62-85
6096143-2	1984	The results show that the replacement of the distal histidine of the hemoglobin beta chains by an arginine greatly enhances the susceptibility of the heme-iron to oxidative challenge.	Arginine	98-106	hemoglobin subunit beta	Homo sapiens	69-84
6593732-4	1984	[Leu]Enk concentrations exceed those of [Met]Enk-Arg-Gly-Leu in certain brain areas such as the substantia nigra, dentate gyrus, globus pallidus, and median eminence (areas rich in dynorphin-related peptides).	Arginine	49-52	proenkephalin	Rattus norvegicus	45-48
6395044-1	1984	The distribution of Met5-enkephalin-Arg6-Phe7 (Met-Enk-Arg-Phe)-like immunoreactivity in the rat gastrointestinal tract was studied by immunohistochemical techniques.	Arginine	36-39	proenkephalin	Rattus norvegicus	25-35
6395044-1	1984	The distribution of Met5-enkephalin-Arg6-Phe7 (Met-Enk-Arg-Phe)-like immunoreactivity in the rat gastrointestinal tract was studied by immunohistochemical techniques.	Arginine	36-39	proenkephalin	Rattus norvegicus	51-54
6395044-2	1984	Antiserum against a Met-Enk-Arg-Phe-thyroglobulin conjugate was raised in rabbits and was found to be specific for synthetic Met-Enk-Arg-Phe.	Arginine	28-31	proenkephalin	Rattus norvegicus	24-27
6395044-2	1984	Antiserum against a Met-Enk-Arg-Phe-thyroglobulin conjugate was raised in rabbits and was found to be specific for synthetic Met-Enk-Arg-Phe.	Arginine	28-31	proenkephalin	Rattus norvegicus	129-132
6395044-3	1984	Met-Enk-Arg-Phe-like immunoreactivity was found in neuronal structures in all parts of the rat gastrointestinal tract.	Arginine	8-11	proenkephalin	Rattus norvegicus	4-7
6434360-4	1984	p-Bromophenacyl bromide, a phospholipase A2 inhibitor, diminished PGE2 release and significantly inhibited both the early and late phases of insulin and glucagon release in response to arginine.	Arginine	185-193	phospholipase A2 group IB	Rattus norvegicus	27-43
6230401-11	1984	The organism apparently responsible for SCF induction from CBA spleen cells was typed and found to be Mycoplasma orale, a nonfermentative, arginine-dependent, common tissue culture contaminant.	Arginine	139-147	kit ligand	Mus musculus	40-43
6704414-9	1984	Labelled apolipoprotein uptake by the heart was reduced by 90% when lipoprotein lipase was first released by heparin or when VLDL was treated with 1,2-cyclohexanedione to modify arginine residues of apolipoproteins.	Arginine	178-186	lipoprotein lipase	Homo sapiens	68-86
6323443-5	1984	Automated Edman degradation of a tryptic peptide containing radioactive carboxamidomethylcysteine showed the sequence of residues Gly-111-Arg-140 of pig kidney fructose 1,6-bisphosphatase.	Arginine	138-141	fructose-bisphosphatase 1	Sus scrofa	160-187
6371080-8	1984	Present evidence with arginine and other intermediates of the urea cycle suggest that these substances influence glucose metabolism and insulin action.	Arginine	22-30	insulin	Bos taurus	136-143
6432224-2	1984	These monoclonals, of IgG2a subclass, blocked in vitro insulin secretion induced by arginine in Mouse pancreatic cells.	Arginine	84-92	immunoglobulin heavy variable V1-9	Mus musculus	22-27
6325477-0	1984	Differential effect of arginine modification with 1,2-cyclohexanedione on the capacity of vimentin and desmin to assemble into intermediate filaments and to bind to nucleic acids.	Arginine	23-31	desmin	Mus musculus	103-109
6325477-1	1984	When the intermediate filament proteins vimentin and desmin were reacted for a short period of time with the arginine-specific reagent 1,2-cyclohexanedione, the modification had a severe, inhibitory effect on the assembly of intermediate filaments and on the susceptibility of the basic, amino-terminal polypeptide of both proteins to degradation by the intermediate filament-specific, Ca2+-activated proteinase.	Arginine	109-117	desmin	Mus musculus	53-59
6318729-2	1983	The arginine residues at positions 38 and 91 of horse cytochrome c are absolutely conserved throughout eukaryotic evolution.	Arginine	4-12	cytochrome c, somatic	Equus caballus	54-66
6318729-3	1983	For studies of the functional roles of these residues, we have prepared, by semisynthetic techniques, analogues of cytochrome c in which one or the other of the arginine residues has been modified.	Arginine	161-169	cytochrome c, somatic	Equus caballus	115-127
6318729-5	1983	In biological tests, the arginine-91-modified cytochrome c showed little difference in behaviour from native horse cytochrome c.	Arginine	25-33	cytochrome c, somatic	Equus caballus	46-58
6639061-11	1983	It is reported that in rabbit tissues thymosin beta 10 is also replaced by a variant, designated thymosin beta arg10, that contains an additional amino acid, arginine, inserted following lysine-38.	Arginine	158-166	thymosin beta-10	Oryctolagus cuniculus	38-54
6136504-1	1983	Evidence for the role of an active site arginine in D-amino acid oxidase.	Arginine	40-48	D-amino acid oxidase	Homo sapiens	52-72
6136504-2	1983	This work presents strong evidence that the role of the active site arginine in D-amino acid oxidase is to act as a positively charged group interacting with the flavin N(1)-C(2) = 0 locus.	Arginine	68-76	D-amino acid oxidase	Homo sapiens	80-100
6136504-3	1983	Modification with cyclohexanedione, which has been shown previously to modify specifically an active site arginine in D-amino acid oxidase (Ferti, C., Curti, B., Simonetta, M. P., Ronchi, S., Galliano, M., and Minchiotti, L. (1981) Eur.	Arginine	106-114	D-amino acid oxidase	Homo sapiens	118-138
6189821-0	1983	Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.	Arginine	0-8	beta-2-microglobulin	Homo sapiens	66-86
6189821-9	1983	Modification of arginines in native beta 2-M and of the single arginine, corresponding to position 45, in the peptide SWH.5 resulted in up to 95% loss of BBM.1 inhibitory activity.	Arginine	16-25	beta-2-microglobulin	Homo sapiens	36-44
6189821-9	1983	Modification of arginines in native beta 2-M and of the single arginine, corresponding to position 45, in the peptide SWH.5 resulted in up to 95% loss of BBM.1 inhibitory activity.	Arginine	16-24	beta-2-microglobulin	Homo sapiens	36-44
6404277-1	1983	Biproduct analogs of lysine and arginine are potent inhibitors of enkephalin convertase, a carboxypeptidase B-like enzyme which appears to be physiologically associated with enkephalin biosynthesis.	Arginine	32-40	carboxypeptidase E	Homo sapiens	66-87
6404277-3	1983	These dicarboxylic acid analogs of arginine are several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase B or N. Kinetic analysis indicates the pure competitive nature of the inhibition.	Arginine	35-43	carboxypeptidase E	Homo sapiens	89-110
6311615-2	1983	A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes.	Arginine	18-21	H3 histone pseudogene 16	Homo sapiens	101-104
6311615-2	1983	A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes.	Arginine	18-21	epidermal growth factor	Homo sapiens	174-177
6311615-2	1983	A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes.	Arginine	22-25	H3 histone pseudogene 16	Homo sapiens	101-104
6311615-2	1983	A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes.	Arginine	22-25	epidermal growth factor	Homo sapiens	174-177
6845437-2	1983	Moderately lysine-rich histones H2A and H2B were found to be more susceptible to acetylation than arginine-rich H3 and H4.	Arginine	98-106	H2B clustered histone 21	Homo sapiens	40-43
10872316-3	1983	The second mechanism, the specific control of arginine biosynthesis, only affects the expression of CPA1.	Arginine	46-54	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	100-104
10872316-6	1983	In contrast, little correlation was found between the levels of CPA1 mRNA and the corresponding protein for conditions affecting repression by arginine: the total amplitude of variation was 6-fold higher for the CPA1 protein than for the CPA1 messenger transcript.	Arginine	143-151	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	64-68
10872316-6	1983	In contrast, little correlation was found between the levels of CPA1 mRNA and the corresponding protein for conditions affecting repression by arginine: the total amplitude of variation was 6-fold higher for the CPA1 protein than for the CPA1 messenger transcript.	Arginine	143-151	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	212-216
10872316-6	1983	In contrast, little correlation was found between the levels of CPA1 mRNA and the corresponding protein for conditions affecting repression by arginine: the total amplitude of variation was 6-fold higher for the CPA1 protein than for the CPA1 messenger transcript.	Arginine	143-151	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	212-216
11894927-6	1983	These results suggest a determining role for the 5" end portion of the arg3 messenger in the specific arginine-mediated control mechanism.	Arginine	102-110	ornithine carbamoyltransferase	Saccharomyces cerevisiae S288C	71-75
7053363-6	1982	T-protein is a basic protein having a pI value of 9.8 and relatively rich in arginine rather than lysine.	Arginine	77-85	aminomethyltransferase	Gallus gallus	0-9
7299136-8	1981	These results suggest that the positively charged residues His-285, Lys-288, Lys-290, and Arg-292, which are located on the outer surface of the C gamma 2 domain, may be involved in the C1q-binding site of human IgG.	Arginine	90-93	complement C1q A chain	Homo sapiens	186-189
6167833-3	1981	The activities of the pyrimidine enzymes, aspartate transcarbamylase (ATC) and dihydroorotate dehydrogenase (DHODH) were significantly increased in rats fed an arginine deficient diet.	Arginine	160-168	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	109-114
6167833-4	1981	ATC and DHODH activities in rats fed the arginine deficient diet returned to control activities after 3 wk of feeding.	Arginine	41-49	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	8-13
6790279-1	1981	Previous studies have shown that a modified form of antithrombin, cleaved at a single Arg-Ser bond near the carboxy-terminal end of the chain, is formed during the reaction with thrombin concurrent with the formation of the inactive enzyme-inhibitor complex.	Arginine	86-89	serpin family C member 1	Homo sapiens	52-64
6161885-5	1981	Pure preparations of polymorphonuclear neutrophils liberate PAF passively, when challenged with C5a, neutrophil cationic proteins (CP), their carboxypeptidase B derived products (C5a des Arg, CP des Arg) or under phagocytic stimuli.	Arginine	187-190	PCNA clamp associated factor	Homo sapiens	60-63
6161885-5	1981	Pure preparations of polymorphonuclear neutrophils liberate PAF passively, when challenged with C5a, neutrophil cationic proteins (CP), their carboxypeptidase B derived products (C5a des Arg, CP des Arg) or under phagocytic stimuli.	Arginine	199-202	PCNA clamp associated factor	Homo sapiens	60-63
7216818-0	1981	Hemoglobin Handsworth (gamma 18 (A16) Gly leads to Arg) in a Chinese.	Arginine	51-54	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	33-36
7329823-7	1981	The Arg and Pro substitutions in the amino terminal region can explain poor crossreactivity of rat gastrin with antibodies specific for the amino-terminal portion of porcine or human gastrin and its more basic chromatography pattern on ion exchange resins.	Arginine	4-7	gastrin	Homo sapiens	183-190
6254959-0	1980	The arginines of cytochrome c.	Arginine	4-13	cytochrome c, somatic	Equus caballus	17-29
7388812-0	1980	Effect of malignant transformation and arginine limitation on fibronectin and other cell surface macromolecules of liver epithelial cultures.	Arginine	39-47	fibronectin 1	Rattus norvegicus	62-73
7388812-4	1980	Arginine limitation was found to produce growth arrest in both normal and malignant liver epithelial cells, concurrent with a marked decrease in the labeling of the surface-associated fibronectin and different surface macromolecular alterations in normal and transformed cells.	Arginine	0-8	fibronectin 1	Rattus norvegicus	184-195
7228251-3	1980	The yields of NPYR formed from pyrrolidine, putrescine, agmatine, spermidine, spermine, proline, ornithine and arginine with nitrite in the pH range 6.6 to 4.0 were determined.	Arginine	111-119	neuropeptide Y receptor Y1	Homo sapiens	14-18
230519-8	1979	The remarkable enhancement of the potency of [Leu]enkephalin by the COOH-terminal extension -Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides.	Arginine	93-96	proenkephalin	Rattus norvegicus	50-60
230519-8	1979	The remarkable enhancement of the potency of [Leu]enkephalin by the COOH-terminal extension -Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH suggests new interpretations concerning the structure of opiate receptors and the function of the enkephalin pentapeptides.	Arginine	93-96	proenkephalin	Rattus norvegicus	226-236
378940-4	1979	Mutants defective in the pro1 and pro2 genes can be satisfied by arginine or ornithine as well as proline.	Arginine	65-73	glutamate 5-kinase	Saccharomyces cerevisiae S288C	25-29
215219-1	1978	Adenylate kinase (ATP:AMP phosphotransferase, EC 2.7.4.3) isolated from porcine skeletal and heart muscle and from rabbit muscle are inactivated when a single arginine residue is modified.	Arginine	159-167	adenylate kinase isoenzyme 1	Oryctolagus cuniculus	18-44
743486-5	1978	Since the cytotoxic activity of LPS-activated macrophages was associated with the release of arginase and was abrogated by excess L-arginine, it is suggested that the biological basis for the selective effects of such macrophages may reside in the L-arginine dependence of the target cells.	Arginine	130-140	interferon regulatory factor 6	Homo sapiens	32-35
743486-5	1978	Since the cytotoxic activity of LPS-activated macrophages was associated with the release of arginase and was abrogated by excess L-arginine, it is suggested that the biological basis for the selective effects of such macrophages may reside in the L-arginine dependence of the target cells.	Arginine	248-258	interferon regulatory factor 6	Homo sapiens	32-35
216665-2	1978	Addition of 2.6 mM arginine, crude repressor and partially purified repressor to the in vitro system demonstrated that lambdadargF-DNA-directed OTCase-FFF synthesis is more sensitive to the repressor than lambdapargI-DNA-directed OTCase-III synthesis.	Arginine	19-27	ornithine transcarbamylase	Homo sapiens	144-150
373354-1	1978	Cathepsin B, purified from isolated islets of Langerhans, when incubated with proinsulin under in vitro conditions could convert proinsulin to insulin and C-peptide, releasing free arginine and lysine.	Arginine	181-189	cathepsin B	Rattus norvegicus	0-11
641033-4	1978	The sequence of D-II indicated high homology with other legume inhibitors, but it was unique because of the occurrence of identical residues (arginine) at both of the reactive sites.	Arginine	142-150	Bowman-Birk type proteinase inhibitor D-II	Glycine max	16-20
623084-2	1978	The intravenous infection of arginine caused an increase of plasma gastrin in hypothyroid patients but was significantly lower than those in normal subjects.	Arginine	29-37	gastrin	Homo sapiens	67-74
904620-0	1977	Essential arginine residues in beef kidney D-aspartate oxidase (a preliminary report).	Arginine	10-18	D-aspartate oxidase	Homo sapiens	43-62
904620-1	1977	Partially purified D-aspartate oxidase from beef kidney has been tested in the presence of butanedione or phenylglyoxal, which specifically modify the arginine molecule.	Arginine	151-159	D-aspartate oxidase	Homo sapiens	19-38
326758-1	1977	Arginase, the enzyme responsible for arginine degradation in Saccharomyces cerevisiae, is an inducible protein whose inhibition of ornithine carbamoyl-transferase has been studied extensively.	Arginine	37-45	arginase	Saccharomyces cerevisiae S288C	0-8
16659859-9	1977	Arginine enhanced the recovery of nitrate reductase in root tips but inhibited it in mature root sections.	Arginine	0-8	nitrate reductase [NADH] 1	Zea mays	34-51
892988-3	1977	A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5-17 and 1-17 amino acid sequences of rat pancreatic ribonuclease.	Arginine	113-116	ribonuclease A family member 1, pancreatic	Rattus norvegicus	281-304
187601-10	1976	The COOH-terminal amino acid of P-450LM2 is arginine, as shown by carboxypeptidase treatment, whereas that of P-450LM4 is lysine.	Arginine	44-52	cytochrome P450 2B4	Oryctolagus cuniculus	32-40
989772-2	1976	The intravenous injection of arginine caused an increase of plasma gastrin in hyperthyroid patients as in normal subjects.	Arginine	29-37	gastrin	Homo sapiens	67-74
129327-17	1976	The homologues with either lysine or arginine in the P1 position are equally good inhibitors of trypsin, plasmin and kallikrein.	Arginine	37-45	plasminogen	Bos taurus	105-112
51849-0	1975	The contribution of phosphorylation and loss of COOH-terminal arginine to the microheterogeneity of myelin basic protein.	Arginine	62-70	myelin basic protein	Cavia porcellus	100-120
1175610-13	1975	This may be similar to that in des-A21, des-B30-insulin, as both lack the Arg-B22--Asn-A21 carboxylate ion pair.	Arginine	74-77	insulin	Bos taurus	48-55
1150641-3	1975	Of the six peaks obtained, two (peaks 1 and 2) contained arginine-rich histones.	Arginine	57-65	pseudopodium enriched atypical kinase 1	Bos taurus	32-45
1118789-1	1975	Previous studies have shown that arginine-stimulated gastrin release disappears after pyloric antrectomy in the human, while conflicting evidence indicates that gastrin is released by the human duodenum.	Arginine	33-41	gastrin	Homo sapiens	53-60
1124345-1	1975	Arginine, administered intravenously, was a more potent stimulus to gastrin release than oral Oxo-feeding, while oral arginine failed to elicit a response in normal subjects.	Arginine	0-8	gastrin	Homo sapiens	68-75
1124345-2	1975	Intravenous arginine stimulated a rise in serum gastrin only in normal subjects but not in antrectomized or vagotomized patients.	Arginine	12-20	gastrin	Homo sapiens	48-55
4596076-0	1974	Plasma gastrin responses to arginine in chronic pancreatitis.	Arginine	28-36	gastrin	Homo sapiens	7-14
4362772-2	1974	l-Arginine, at a concentration of 0.1 mM in the growth medium, led to a reduction of the EBV capsid antigen content of the EB1 and EB3 cells lines as determined by indirect immunofluorescence, and M. arginini infection enhanced this reduction.	Arginine	0-10	microtubule associated protein RP/EB family member 3	Homo sapiens	131-134
4362772-5	1974	The addition of arginine to a final concentration of 0.6 mM in the growth medium caused a dual effect: the EB1 and EB3 cell lines maintained the original level of EBV capsid antigens, even when infected with M. arginini; immune product synthesis was greatly reduced or completely inhibited by the addition of arginine, and M. arginini infection caused no further reduction of immune product synthesis.	Arginine	16-24	microtubule associated protein RP/EB family member 3	Homo sapiens	115-118
34029587-3	2021	We confirmed arginine methylation of N protein by immunoblotting viral proteins extracted from SARS-CoV-2 virions isolated from cell culture.	Arginine	13-21	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	37-38
34008450-6	2021	RESULTS: The data showed that prolonged NMDA-R antagonism, induced by subchronic PCP treatment, impairs long-term potentiation (LTP) and the facilitatory effect of BDNF upon LTP in the medial prefrontal cortex (PFC) of adult mice.	Arginine	0-1	brain derived neurotrophic factor	Mus musculus	164-168
34015761-3	2021	Transcriptomic analysis revealed that the amino acid biosynthesis pathways such as serine, arginine and cysteine were impaired, and associated critical enzymes were downregulated in Pkd2-knockout mouse kidneys.	Arginine	91-99	polycystin 2, transient receptor potential cation channel	Mus musculus	182-186
34010774-3	2021	Here, inspired by the biological function and self-assembling ability of arginine (R), we synthesized arginine-rich peptide-Pt nanoparticle cluster (ARP-PtNC) nanozymes that mimic two typical enzymatic cascade systems of uricase/catalase and superoxide dismutase/catalase in natural peroxisome.	Arginine	73-81	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	149-152
34010774-3	2021	Here, inspired by the biological function and self-assembling ability of arginine (R), we synthesized arginine-rich peptide-Pt nanoparticle cluster (ARP-PtNC) nanozymes that mimic two typical enzymatic cascade systems of uricase/catalase and superoxide dismutase/catalase in natural peroxisome.	Arginine	83-84	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	149-152
33887226-8	2021	A newly identified RBD motif of RILPL2, termed the X-cap, has been shown to recognize the phosphate via direct interactions between an arginine residue (R132) and pT72 of Rab8a.	Arginine	135-143	RAB8A, member RAS oncogene family	Homo sapiens	171-176
33887226-9	2021	Here we show that a second "distal" arginine (R130) is also essential for phospho-Rab binding by RILPL2.	Arginine	36-44	RAB8A, member RAS oncogene family	Homo sapiens	82-85
33974913-6	2021	We implicate Ubr1, an E3 of the Arg/N-degron pathway, in targeting mitochondrial proteins processed by the mitochondrial inner membrane protease.	Arginine	32-35	E3 ubiquitin-protein ligase UBR1	Saccharomyces cerevisiae S288C	13-17
33844918-3	2021	Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (R/S-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via pi-pi stacking interaction between chiral N,N"-dimethyl-binaphthyldiamine enantiomers (R/S-NMe2) and the achiral pyrene derivative (Py-2).	Arginine	90-91	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	94-98
33844918-3	2021	Herein, we synthesized three achiral pyrene derivatives, but only the chiral co-assembly (R/S-NMe2-Py-2) can exhibit the regular and orderly helical nanofiber via pi-pi stacking interaction between chiral N,N"-dimethyl-binaphthyldiamine enantiomers (R/S-NMe2) and the achiral pyrene derivative (Py-2).	Arginine	90-91	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	254-258
34017581-7	2021	RESULTS: The expression of lncRNA RMST was significantly increased with H/R or H2O2 treatment.	Arginine	0-1	rhabdomyosarcoma 2 associated transcript (non-coding RNA)	Mus musculus	34-38
33920834-7	2021	The interactions between D77-R280 and T243-TM7 could be related to the functional conformation of CXCR6; alternatively, the interaction between Q195-Q244 and N248 could be related to an inactive state due to the loss of this interaction, and an arginine cage broken in the presence of CXCL16s allows the meta-active state of CXCR6.	Arginine	245-253	C-X-C motif chemokine receptor 6	Homo sapiens	98-103
33920834-7	2021	The interactions between D77-R280 and T243-TM7 could be related to the functional conformation of CXCR6; alternatively, the interaction between Q195-Q244 and N248 could be related to an inactive state due to the loss of this interaction, and an arginine cage broken in the presence of CXCL16s allows the meta-active state of CXCR6.	Arginine	245-253	C-X-C motif chemokine receptor 6	Homo sapiens	325-330
33838671-9	2021	ASS1 overexpression effectively inhibited tumor growth and enhanced the efficacy of in vitro and in vivo anti-HCC combination chemotherapy via activation of the PERK/eIF2alpha/ATF4/CHOP axis, but was not dependent on the status of p53 and arginine metabolism.	Arginine	239-247	argininosuccinate synthase 1	Homo sapiens	0-4
33421141-0	2021	Dual roles of the Serine/Arginine-rich splicing factor SR45a in promoting and interacting with nuclear cap-binding complex to modulate the salt stress response in Arabidopsis.	Arginine	25-33	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	55-60
33790413-8	2022	RESULTS: In this study, a novel homozygous BRAT1 variant c.233G > C with amino acid change of R with P at residue 78 (R78P) was identified.	Arginine	0-1	BRCA1 associated ATM activator 1	Homo sapiens	43-48
33691113-5	2021	Moreover, intracellular E. piscicida recruits the host arginine importer (mCAT-1) and putrescine exporter (Oct-2) to bacterium-containing vacuoles, accompanied by reduced arginine and accumulated cytosolic spermine.	Arginine	55-63	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	74-80
33691113-5	2021	Moreover, intracellular E. piscicida recruits the host arginine importer (mCAT-1) and putrescine exporter (Oct-2) to bacterium-containing vacuoles, accompanied by reduced arginine and accumulated cytosolic spermine.	Arginine	171-179	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	74-80
33682127-6	2021	The gels containing 15/20 mM Lys/Arg exhibited a significant increase in the proportion of immobilized water (P21 ).	Arginine	33-36	H3 histone pseudogene 16	Homo sapiens	110-113
33682127-7	2021	CONCLUSION: The enhancement of WHC, gel strength, and P21 was closely associated with the increased solubility and the dense microstructure induced by Lys and Arg with high concentrations of 15 mM and 20 mM.	Arginine	159-162	H3 histone pseudogene 16	Homo sapiens	54-57
32702113-8	2021	Besides, blockage of M2 polarization by Arg-1 inhibitor abrogated the effect of recombinant SLAMF7 in disease progression.	Arginine	40-43	SLAM family member 7	Mus musculus	92-98
33667543-0	2021	Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.	Arginine	0-8	SMAD family member 6	Homo sapiens	31-36
33667543-5	2021	Here, using biochemical approach and cell differentiation systems, we report a cytosolic mechanism of action for Smad6 that requires arginine methylation at R81 and functions through association with Smad1 and interference with the formation of Smad1/Smad4 complexes.	Arginine	133-141	SMAD family member 6	Homo sapiens	113-118
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 6	Homo sapiens	175-180
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 6	Homo sapiens	242-247
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	SMAD family member 6	Homo sapiens	242-247
33147120-0	2021	The conserved arginine required for AvrRps4 processing is also required for recognition of its N-terminal fragment in lettuce.	Arginine	14-22	ribosomal protein S4	Arabidopsis thaliana	36-43
33147120-7	2021	Surprisingly, the conserved arginine at position 112 (R112) that is required for full-length AvrRps4 processing is also required for the recognition of AvrRps4-N by lettuce.	Arginine	28-36	ribosomal protein S4	Arabidopsis thaliana	93-100
33147120-7	2021	Surprisingly, the conserved arginine at position 112 (R112) that is required for full-length AvrRps4 processing is also required for the recognition of AvrRps4-N by lettuce.	Arginine	28-36	ribosomal protein S4	Arabidopsis thaliana	152-159
34026434-7	2021	Mechanistically, PRMT5 binds to and methylates Smad7 on Arg-57, enhances Smad7 binding to IL-6 co-receptor gp130, and consequently ensures robust STAT3 activation.	Arginine	56-59	interleukin 6 cytokine family signal transducer	Homo sapiens	107-112
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	beclin 1, autophagy related	Mus musculus	151-159
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	interleukin 1 alpha	Mus musculus	244-253
33453267-4	2021	Here, we show that charged arginine (R) residues in even short glycine (G) capped model peptides (GRRG and GRRRG) significantly affect the conformational propensities of each other when compared to the intrinsic propensities of a mostly unperturbed arginine in the tripeptide GRG.	Arginine	27-35	TLE family member 5, transcriptional modulator	Homo sapiens	276-279
33574402-0	2021	Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase.	Arginine	113-123	N-acetylglutamate synthase	Mus musculus	138-164
33189720-3	2021	Isolated vacuolar membrane vesicles from S. cerevisiae cells overexpressing stm1+ exhibited stm1+-dependent arginine and lysine uptake activity.	Arginine	108-116	Stm1p	Saccharomyces cerevisiae S288C	76-80
33189720-3	2021	Isolated vacuolar membrane vesicles from S. cerevisiae cells overexpressing stm1+ exhibited stm1+-dependent arginine and lysine uptake activity.	Arginine	108-116	Stm1p	Saccharomyces cerevisiae S288C	92-96
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Arginine	21-29	Stm1p	Saccharomyces cerevisiae S288C	138-142
33189720-4	2021	Exchange activity of arginine and histidine/arginine, as observed for Ypq2 of S. cerevisiae, was also detected in the vesicles expressing stm1+.	Arginine	44-52	Stm1p	Saccharomyces cerevisiae S288C	138-142
33189720-5	2021	The expression levels of stm1+ in S. pombe cells significantly affected the vacuolar contents of lysine, histidine, and arginine.	Arginine	120-128	Stm1p	Saccharomyces cerevisiae S288C	25-29
33290345-6	2021	The antidepressant-like effect of carbamazepine (40 mg/kg, intraperitoneal) was prevented by pretreatment with L-arginine [substrate for NO synthase (NOS), 750 mg/kg, intraperitoneal], sildenafil (a PDE-5 inhibitor, 5 mg/kg, intraperitoneal) and diazoxide (K channels opener, 10 mg/kg).	Arginine	111-121	phosphodiesterase 5A, cGMP-specific	Mus musculus	199-204
32525264-5	2021	Compared to galectin-1, -3 and -8, Gal-14 has two key amino acids (a histidine and an arginine) in the normally conserved, canonical sugar binding site are substituted by glutamine (Gln53) and histidine (His57), thus likely explaining why lactose binding to this lectin is very weak.	Arginine	86-94	galectin 14	Homo sapiens	35-41
32605511-8	2021	Silencing of BCL2L11 and caspase-2 both, respectively, counteracted the H9c2 cell injury caused by H/R treatment.	Arginine	101-102	Bcl2-like 11	Rattus norvegicus	13-20
33495423-5	2021	Furthermore, recombinant murine IL-22 (rIL-22) was administrated to L-arginine-induced SAP mice by intraperitoneal injection.	Arginine	68-78	interleukin 22	Mus musculus	32-37
33664852-1	2021	Arginine synthesis deficiency due to the suppressed expression of ASS1 (argininosuccinate synthetase 1) represents one of the most frequently occurring metabolic defects of tumor cells.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	66-70
33664852-1	2021	Arginine synthesis deficiency due to the suppressed expression of ASS1 (argininosuccinate synthetase 1) represents one of the most frequently occurring metabolic defects of tumor cells.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	72-102
33465109-3	2021	We identified by whole exome sequencing an extremely rare Arg to Gln variant (Arg89Gln) in the Microtubule Associated Serine/Threonine Kinase 2 (MAST2) gene that segregates with VTE in the family.	Arginine	58-61	microtubule associated serine/threonine kinase 2	Homo sapiens	95-143
33465109-3	2021	We identified by whole exome sequencing an extremely rare Arg to Gln variant (Arg89Gln) in the Microtubule Associated Serine/Threonine Kinase 2 (MAST2) gene that segregates with VTE in the family.	Arginine	58-61	microtubule associated serine/threonine kinase 2	Homo sapiens	145-150
33423701-3	2021	L-arginine is a non-essential amino acid synthesized from L-citrulline by the Arginosuccinate synthetase (ASS1) enzyme.	Arginine	0-10	argininosuccinate synthase 1	Homo sapiens	106-110
33419170-5	2021	Several genes associated with oxidative stress response and neuronal excitotoxic cell death, including Nr4a1, Arc, and Cyr61, remarkably increased in response to psychosocial stress; however, their expression was significantly suppressed in mice that ingested Arg even under stress conditions.	Arginine	260-263	nuclear receptor subfamily 4, group A, member 1	Mus musculus	103-108
33225718-0	2021	Arginine site 264 in murine estrogen receptor alpha is dispensable for the regulation of the skeleton.	Arginine	0-8	estrogen receptor 1 (alpha)	Mus musculus	28-51
33202281-8	2021	RESULTS: l-arginine group displayed AP as manifested by a significant increase in serum lipase and amylase, MDA, NOx, IL-6, TNF-alpha, caspase-3 with iNOS immuno-expression.	Arginine	9-19	lipase G, endothelial type	Rattus norvegicus	88-94
33758649-5	2021	Specifically, the Arginine 69 residue in the SARS-CoV-2 E-SLiM is the key residue able to both enhance the specific polar interaction with negatively charged pockets of the PALS1 PDZ domain and reduce significantly the mobility of the viral peptide.	Arginine	18-26	protein associated with LIN7 1, MAGUK p55 family member	Homo sapiens	173-178
33391421-1	2021	Introduction: Previous studies have shown that peptides containing the asparagine-glycine-arginine (NGR) sequence can specifically bind to CD13 (aminopeptidase N) receptor, a tumor neovascular biomarker that is over-expressed on the surface of angiogenic blood vessels and various tumor cells, and it plays an important role in angiogenesis and tumor progression.	Arginine	90-98	alanyl (membrane) aminopeptidase	Mus musculus	139-143
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	nucleotide-binding oligomerization domain containing 1	Mus musculus	38-42
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	138-144
33189269-8	2021	The increased Arg alone downregulated NOD1 after iE-DAP stimulation, coupled with a downregulation in the AA transporters mRNA abundance (SLC7A1, SLC7A5, SLC3A2, and SLC38A9), and upregulation in GSS and KEAP1 mRNA abundance.	Arginine	14-17	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	154-160
33181440-7	2021	Human Hsp90alpha was found to significantly increase superoxide generation from nNOSmu and nNOSalpha proteins under l-Arg-depleted conditions and Hsp90alpha influenced superoxide production by nNOSmu and nNOSalpha at varying degrees.	Arginine	116-121	heat shock protein 90 alpha family class A member 1	Homo sapiens	6-16
33025106-6	2021	Moreover, immunosuppressive cells suppress the function of effector immune cells by catabolizing L-arginine and tryptophan through the activation of arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO), respectively.	Arginine	97-107	indoleamine 2,3-dioxygenase 1	Homo sapiens	171-198
33025106-6	2021	Moreover, immunosuppressive cells suppress the function of effector immune cells by catabolizing L-arginine and tryptophan through the activation of arginase 1 (ARG1) and indoleamine 2,3-dioxygenase (IDO), respectively.	Arginine	97-107	indoleamine 2,3-dioxygenase 1	Homo sapiens	200-203
33249828-9	2020	Heterologous expression of the PAD gene in a des-citrulassin producer resulted in the production of the deiminated analog, confirming PAD involvement in Arg deimination.	Arginine	153-156	peptidyl arginine deiminase 4	Homo sapiens	31-34
33249828-9	2020	Heterologous expression of the PAD gene in a des-citrulassin producer resulted in the production of the deiminated analog, confirming PAD involvement in Arg deimination.	Arginine	153-156	peptidyl arginine deiminase 4	Homo sapiens	134-137
33303990-6	2021	Similar results were observed in L-arg-pretreated cultured endothelial cells, showing markedly decreased ROS accumulation and AKT/eNOS/NO signaling impairment induced by aflibercept.	Arginine	33-38	nitric oxide synthase 3, endothelial cell	Mus musculus	130-134
33296647-8	2020	Taken together, our study uncovers a non-canonical function of nuclear-localized cGAS in innate immunity via regulating histone arginine modification.	Arginine	128-136	cyclic GMP-AMP synthase	Homo sapiens	81-85
33260152-3	2020	Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that catalyzes mono- and di-methylation on arginine residues within histone and non-histone proteins to modulate a variety of life processes, such as apoptosis.	Arginine	8-16	protein arginine N-methyltransferase 6	Mus musculus	38-43
33160404-6	2020	We carried out a multivariate Cox regression analysis and developed six ARG-related prognostic signature for the survival prediction of patients with squamous cell cervical cancer (Risk score = - 0.63*ATG3-0.42*BCL2 + 0.85*CD46-0.38*IFNG+ 0.23*NAMPT+ 0.82*TM9SF1).	Arginine	72-75	transmembrane 9 superfamily member 1	Homo sapiens	256-262
33395072-5	2020	Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy.	Arginine	87-95	argininosuccinate synthase 1	Homo sapiens	19-49
33395072-5	2020	Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy.	Arginine	87-95	argininosuccinate synthase 1	Homo sapiens	51-55
33395072-5	2020	Due to the loss of argininosuccinate synthetase 1 (ASS1) expression, the key enzyme in arginine biosynthesis, arginine deprivation is regarded as a potential strategy for PDAC therapy.	Arginine	110-118	argininosuccinate synthase 1	Homo sapiens	19-49
33093276-2	2020	We reported opposite regulations of TREK-2 by phosphatidylinositol 4,5-bisphosphate (PIP2) via the alkaline K330 and triple Arg residues (R355-357); inhibition and activation, respectively.	Arginine	124-127	potassium two pore domain channel subfamily K member 10	Homo sapiens	36-42
32938720-5	2020	The Arg144Cys variation in the *2 complex disrupts the hydrogen-bonding interactions that were observed between the side chain of arginine and neighboring residues in the losartan complex of CYP2C9 and the wild-type (WT) ligand-free structure.	Arginine	130-138	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	191-197
33122522-0	2020	Inhibition of CHRM3 Alleviates Necrosis Via the MAPK-p38/miR-31-5p/RIP3 Axis in L-Arginine-Induced Severe Acute Pancreatitis.	Arginine	80-90	microRNA 31	Mus musculus	57-63
33122522-8	2020	CONCLUSIONS: Necrosis in L-arginine-induced SAP is promoted by CHRM3 through the mitogen-activated protein kinase-p38/miR-31-5p/RIP3 axis.	Arginine	25-35	microRNA 31	Mus musculus	118-124
33097830-0	2020	Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b.	Arginine	10-20	wingless-type MMTV integration site family, member 2B	Mus musculus	114-119
33097830-6	2020	Mechanistically, we find that L-arginine stimulates Wnt2b secretion by CD90+ stromal cells through the mammalian target of rapamycin complex 1 (mTORC1) and that blocking Wnt2b production prevents L-arginine-induced ISC expansion.	Arginine	30-40	Thy-1 cell surface antigen	Homo sapiens	71-75
33081101-7	2020	Results: 3-chlorotyrosine, a HOCl-specific damage marker, decreased within the heart of animals in the AMI/R + 4-MetT group 24 h post-AMI, indicating the drug inhibited MPO activity; however, there was no evident difference in either infarct size or myocardial scar size between the groups.	Arginine	0-1	myeloperoxidase	Rattus norvegicus	169-172
33011746-8	2020	Importantly, a multiple alignment has demonstrated that both Serine-384 and Arg-378 residues are highly conservative across all members of caspase family, which allows us to suggest that this diade is indispensable for caspase processing and activity.	Arginine	76-79	caspase 2	Homo sapiens	139-146
33011746-8	2020	Importantly, a multiple alignment has demonstrated that both Serine-384 and Arg-378 residues are highly conservative across all members of caspase family, which allows us to suggest that this diade is indispensable for caspase processing and activity.	Arginine	76-79	caspase 2	Homo sapiens	219-226
32631905-8	2020	Metabolomics and complex lipid profiling of cells and tumors with reduced Aqp7 revealed significantly altered lipid metabolism, glutathione metabolism, and urea/arginine metabolism compared to controls.	Arginine	161-169	aquaporin 7	Mus musculus	74-78
32573723-0	2020	Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.	Arginine	34-42	CXADR pseudogene 1	Homo sapiens	69-72
32573723-2	2020	However, the resulting low arginine microenvironment also impairs chimeric antigen receptor T cells (CAR-T) cell proliferation, limiting their efficacy in clinical trials against haematological and solid malignancies.	Arginine	27-35	CXADR pseudogene 1	Homo sapiens	101-104
32573723-3	2020	T cells are susceptible to the low arginine microenvironment due to the low expression of the arginine re-synthesis enzymes argininosuccinate synthase (ASS) and ornithine transcarbamylase (OTC).	Arginine	35-43	argininosuccinate synthase 1	Homo sapiens	124-150
32573723-3	2020	T cells are susceptible to the low arginine microenvironment due to the low expression of the arginine re-synthesis enzymes argininosuccinate synthase (ASS) and ornithine transcarbamylase (OTC).	Arginine	35-43	ornithine transcarbamylase	Homo sapiens	161-187
32573723-3	2020	T cells are susceptible to the low arginine microenvironment due to the low expression of the arginine re-synthesis enzymes argininosuccinate synthase (ASS) and ornithine transcarbamylase (OTC).	Arginine	94-102	argininosuccinate synthase 1	Homo sapiens	124-150
32447347-0	2020	Arginine hypomethylation-mediated proteasomal degradation of histone H4-an early biomarker of cellular senescence.	Arginine	0-8	H4 clustered histone 6	Homo sapiens	61-71
32447347-5	2020	Noticeably, asymmetric demethylation of histone H4 at arginine 3 (H4R3me2as), catalyzed by PRMT1, was decreased prior to histone H4.	Arginine	54-62	H4 clustered histone 6	Homo sapiens	40-50
32814773-0	2020	Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming.	Arginine	27-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	55-58
32814773-6	2020	When integrated with metabolomic profiling, this multi-omic analysis reveals that cellular response to arginine starvation is mediated by adaptive ERK signaling and activation of the Myc-Max transcriptional network.	Arginine	103-111	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	183-186
32697566-4	2020	Once activated by GOx-catalyzed glucose oxidation, a large amount of oxygen radicals, toxic ONOO- and NO are rapidly produced over this well-designed L-Arg/GOx@CuBDC through a double-cascade reaction.	Arginine	150-155	hydroxyacid oxidase 1, liver	Mus musculus	18-21
32697566-4	2020	Once activated by GOx-catalyzed glucose oxidation, a large amount of oxygen radicals, toxic ONOO- and NO are rapidly produced over this well-designed L-Arg/GOx@CuBDC through a double-cascade reaction.	Arginine	150-155	hydroxyacid oxidase 1, liver	Mus musculus	156-159
32697566-6	2020	In addition, the in vivo experiment in mice demonstrated that the as-prepared L-Arg/GOx@CuBDC has good biocompatibility, indicating its good potential in practical applications.	Arginine	78-83	hydroxyacid oxidase 1, liver	Mus musculus	84-87
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	COPI coat complex subunit gamma 2	Homo sapiens	213-223
32627789-1	2020	Reactions of trans-[(dmpe)2MnH(C2H4)] (1) with BH3(NMe3), 9-BBN, and HBMes2 yielded the manganese(i) borohydride complexes [(dmpe)2Mn(mu-H)2BR2] (3: R = H, 4: R2 = C8H14, 5: R = Mes).	Arginine	0-1	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	51-55
32725957-5	2020	Moreover, enhanced the expression of Wnt3a in Paneth cells, which is a ligand of the Wnt/beta-catenin signaling pathway, mediates the effects of L-arginine on ISCs function.	Arginine	145-155	wingless-type MMTV integration site family, member 3A	Mus musculus	37-42
32725957-5	2020	Moreover, enhanced the expression of Wnt3a in Paneth cells, which is a ligand of the Wnt/beta-catenin signaling pathway, mediates the effects of L-arginine on ISCs function.	Arginine	145-155	wingless-type MMTV integration site family, member 3A	Mus musculus	37-40
32725957-7	2020	Our findings establish that the regulation of Wnt3a in the Paneth cell niche by exogenous L-arginine couples ISCs function and favours a model in which the ISCs niche couples the nutrient levels to ISCs function.	Arginine	90-100	wingless-type MMTV integration site family, member 3A	Mus musculus	46-51
32246827-4	2020	Using a panel of three BLVRB isoforms (human, lemur, and hyrax) and multiple human BLVRB mutants, our studies reveal a novel evolutionary mechanism where coenzyme "clamps" formed by arginine side chains at two co-evolving positions within the active site serve to slow coenzyme-release (position 14 and 78).	Arginine	182-190	biliverdin reductase B	Homo sapiens	23-28
32246827-4	2020	Using a panel of three BLVRB isoforms (human, lemur, and hyrax) and multiple human BLVRB mutants, our studies reveal a novel evolutionary mechanism where coenzyme "clamps" formed by arginine side chains at two co-evolving positions within the active site serve to slow coenzyme-release (position 14 and 78).	Arginine	182-190	biliverdin reductase B	Homo sapiens	83-88
32412630-7	2020	Arg supplementation decreased (P < 0.05) the protein abundance of apoptosis antigen 1 (FAS) (52.0% and 43.9%) but increased (P < 0.05) those of nuclear respiratory factor 1 (31.3% and 22.9%) and inducible NO synthase (35.2% and 41.8%) relative to the CON and CON + NAME groups, respectively.	Arginine	0-3	Fas cell surface death receptor	Homo sapiens	66-85
32696344-0	2020	Heterologous expression, purification, and refolding of SRY protein: role of L-arginine as analyzed by simulation and practical study.	Arginine	77-87	sex-determining region Y protein	Bos taurus	56-59
32696344-2	2020	The purpose of this study was to improve the solubility of recombinant bovine sex-determining region Y protein (rbSRY) by exploring the effect of temperature, inducer, and water-arginine mixed solvent.	Arginine	178-186	sex-determining region Y protein	Bos taurus	78-110
32696344-4	2020	A three-dimensional model of SRY was built and studied through molecular dynamics simulations in water and in the presence of L-arginine as co-solvent.	Arginine	126-136	sex-determining region Y protein	Bos taurus	29-32
32696344-7	2020	Based on molecular modeling results, the propensity of fragments in the N-terminal domain to form beta-sheet and the relative instability of alpha-helices in terminal domains are the probable reasons for the high aggregation potential of SRY, which are mitigated in the presence of L-arginine.	Arginine	282-292	sex-determining region Y protein	Bos taurus	238-241
33194339-11	2020	EIF4EBP1 may be a key ARG which had a higher expression level in patients with more malignant molecular subtypes and higher grade breast cancer.	Arginine	22-25	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	0-8
33194339-13	2020	EIF4EBP1 may be a key ARG associated with breast cancer survival.	Arginine	22-25	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	0-8
32457044-8	2020	Arg-161 in the active site of CblC suppressed the NO2Cbl-dependent thiol oxidase activity, whereas the disease-associated R161G variant stabilized cob(II)alamin and promoted futile cycling.	Arginine	0-3	Cbl proto-oncogene C	Homo sapiens	30-34
32532885-3	2020	Here we demonstrate that a likely mechanism underlying the orexigenic action of RLN3 is RXFP3-mediated inhibition of oxytocin- and arginine-vasopressin-synthesizing paraventricular nucleus (PVN) magnocellular neurosecretory cells.	Arginine	131-139	relaxin 3	Rattus norvegicus	80-84
32271476-4	2020	Whole-exome sequencing (WES) of the patient ascertained the heterozygous missense variant (c.274C>T) in the NR5A1 gene, resulting in a substitution of arginine with tryptophan.	Arginine	151-159	nuclear receptor subfamily 5 group A member 1	Homo sapiens	108-113
32271476-5	2020	The arginine 92 residue was located in a highly conserved region of steroidogenic factor 1 (SF1), which is crucial for its interaction with DNA.	Arginine	4-12	nuclear receptor subfamily 5 group A member 1	Homo sapiens	68-90
32271476-5	2020	The arginine 92 residue was located in a highly conserved region of steroidogenic factor 1 (SF1), which is crucial for its interaction with DNA.	Arginine	4-12	nuclear receptor subfamily 5 group A member 1	Homo sapiens	92-95
32545869-6	2020	Partial ablation of the Arg/N-degron pathway greatly increases IL-1beta secretion, indicating the importance of this ubiquitous pathway in the initiation and resolution of inflammation.	Arginine	24-27	interleukin 1 alpha	Homo sapiens	63-71
31448769-6	2020	Sequencing of IGSF1 gene revealed a novel genetic change c.3805C&gt;T in exon 19 that resulted in substitution of aminoacid Arginine 1269 with a &lt;&lt;stop&gt;&gt; codon and the production of an altered protein product.	Arginine	124-132	immunoglobulin superfamily member 1	Homo sapiens	14-19
32421439-2	2020	A naturally occurring single nucleotide polymorphism in the key extracellular antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), results in an arginine to glycine substitution (R213G) which promotes resolution of inflammation and protection against bleomycin-induced ALI.	Arginine	157-165	superoxide dismutase 3, extracellular	Mus musculus	98-132
32421439-2	2020	A naturally occurring single nucleotide polymorphism in the key extracellular antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), results in an arginine to glycine substitution (R213G) which promotes resolution of inflammation and protection against bleomycin-induced ALI.	Arginine	157-165	superoxide dismutase 3, extracellular	Mus musculus	134-140
32380753-11	2020	The in vivo study showed that arginine infusion promoted milk protein content, casein yield and the expression of CSN1S1 and CSN1S2.	Arginine	30-38	casein alpha s1	Bos taurus	114-120
32380753-12	2020	Furthermore, the expression of miR-743a, miR-543, miR-101a, miR-760-3p, miR-1954, and miR-712 was also greater in response to arginine injection compared with the control or alanine group.	Arginine	126-134	microRNA 543	Bos taurus	41-48
32380753-13	2020	Overall, results both in vivo and in vitro revealed that arginine might partly influence casein yield by altering the expression of 6 miRNAs (miR-743a, miR-543, miR-101a, miR-760-3p, miR-1954, and miR-712).	Arginine	57-65	microRNA 543	Bos taurus	152-159
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	63-71	carboxypeptidase D	Homo sapiens	16-34
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	63-71	carboxypeptidase D	Homo sapiens	36-39
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	73-76	carboxypeptidase D	Homo sapiens	16-34
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	73-76	carboxypeptidase D	Homo sapiens	36-39
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	113-116	carboxypeptidase D	Homo sapiens	16-34
32509382-1	2020	Plasma membrane carboxypeptidase-D (CPD) hydrolyzes C-terminal arginine (Arg) from extracellular substrates, and Arg is converted into nitric oxide (NO) in the cell.	Arginine	113-116	carboxypeptidase D	Homo sapiens	36-39
32113649-3	2020	In IWC-I, the mutations lead to replacement of glycine/serine-rich keratin 10 (K10) tail with arginine- or alanine-rich frameshift motifs, causing K10 mis-localization which might trigger loss of the mutant KRT10 allele via mitotic recombination, leading to genetic reversion.	Arginine	94-102	keratin 10	Homo sapiens	79-82
32113649-3	2020	In IWC-I, the mutations lead to replacement of glycine/serine-rich keratin 10 (K10) tail with arginine- or alanine-rich frameshift motifs, causing K10 mis-localization which might trigger loss of the mutant KRT10 allele via mitotic recombination, leading to genetic reversion.	Arginine	94-102	keratin 10	Homo sapiens	147-150
32113649-3	2020	In IWC-I, the mutations lead to replacement of glycine/serine-rich keratin 10 (K10) tail with arginine- or alanine-rich frameshift motifs, causing K10 mis-localization which might trigger loss of the mutant KRT10 allele via mitotic recombination, leading to genetic reversion.	Arginine	94-102	keratin 10	Homo sapiens	207-212
32113649-8	2020	Two of the mutations, c.1696_1699dupCACA and c.1676dupG, affected residues close to K10 carboxyl terminus and encoded only 3 and 6 arginine residues, which were far fewer than reported previously.	Arginine	131-139	keratin 10	Homo sapiens	84-87
32113649-10	2020	CONCLUSIONS: Our findings suggest that the number of arginine residues in the mutant tail may correlate with the level of K10 mis-localization in IWC-I keratinocytes.	Arginine	53-61	keratin 10	Homo sapiens	122-125
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	87-90	melanocortin 4 receptor	Mus musculus	64-68
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	154-157	melanocortin 4 receptor	Mus musculus	64-68
32155745-3	2020	In bacteria, plants, and fungi Put is synthesized also from agmatine, which is formed from L-arginine by arginine decarboxylase (ADC).	Arginine	91-101	antizyme inhibitor 2	Homo sapiens	105-127
32155745-3	2020	In bacteria, plants, and fungi Put is synthesized also from agmatine, which is formed from L-arginine by arginine decarboxylase (ADC).	Arginine	91-101	antizyme inhibitor 2	Homo sapiens	129-132
32064872-0	2020	L-arginine ameliorates lipopolysaccharide-induced intestinal inflammation through inhibiting the TLR4/NF-kappaB and MAPK pathways and stimulating beta-defensins expression in vivo and in vitro.	Arginine	0-10	toll like receptor 4	Homo sapiens	97-101
32064872-4	2020	In porcine intestinal epithelial cells (IPEC-J2), L-arginine obviously suppressed (p &lt; 0.05) the levels of IL-6 (220.63 +- 2.82), IL-8 (333.95 +- 3.75), IL-1beta (693.08 +- 2.38) and TNF-alpha (258.04 +- 4.14) induced by LPS.	Arginine	50-60	interleukin 1 alpha	Homo sapiens	156-164
32064872-5	2020	Furthermore, L-arginine diminished the LPS-induced expression of toll-like receptor 4 (TLR4) and inhibited activation of TLR4-mediated nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	Arginine	13-23	toll like receptor 4	Homo sapiens	65-85
32064872-5	2020	Furthermore, L-arginine diminished the LPS-induced expression of toll-like receptor 4 (TLR4) and inhibited activation of TLR4-mediated nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	Arginine	13-23	toll like receptor 4	Homo sapiens	87-91
32064872-5	2020	Furthermore, L-arginine diminished the LPS-induced expression of toll-like receptor 4 (TLR4) and inhibited activation of TLR4-mediated nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	Arginine	13-23	toll like receptor 4	Homo sapiens	121-125
32064872-8	2020	The present study indicated L-arginine enhanced disease resistance through inhibiting the TLR4/NF-kappaB and MAPK pathways and partially, possibly through increasing the intestinal beta-defensins expression.	Arginine	28-38	toll like receptor 4	Homo sapiens	90-94
32194638-10	2020	This novel mutation resulted in a substitution of arginine by tryptophan, leading to antithrombin resistance (ATR).	Arginine	50-58	serpin family C member 1	Homo sapiens	85-97
32122398-10	2020	Co-occurrence patterns revealed by network analysis showed that emrD, emrY, ANT(6)-Ia, and tetO, the hubs of ARG type network, are indicators of other co-occurring ARG types.	Arginine	109-112	solute carrier family 25 member 6	Homo sapiens	76-79
32122398-10	2020	Co-occurrence patterns revealed by network analysis showed that emrD, emrY, ANT(6)-Ia, and tetO, the hubs of ARG type network, are indicators of other co-occurring ARG types.	Arginine	164-167	solute carrier family 25 member 6	Homo sapiens	76-79
31622532-3	2020	Optimal solution conditions for arginine viral inactivation found in the literature are high arginine concentrations (0.7-1 M), a time of 60 min, and a synergistic factor of high temperature (>=40 C), low pH (<=pH 4), or Tris buffer (5 mM).	Arginine	32-40	prolyl 4-hydroxylase, transmembrane	Homo sapiens	211-215
32066366-9	2020	In the conserved clusters, the preferred residues are the hydrophobic (Leu, Ile, Met), aromatic (Tyr, Phe, Trp) and interestingly only one positively charged Arg residues.	Arginine	158-161	SAFB like transcription modulator	Homo sapiens	81-84
31732298-4	2020	Moreover, miR24-2 inhibits the di-/tri-methylation of histone H4 arginine 3 by reducing PRMT7 and then promotes the expression of Nanog via long noncoding RNA HULC.	Arginine	65-73	microRNA 24-2	Homo sapiens	10-17
31732298-4	2020	Moreover, miR24-2 inhibits the di-/tri-methylation of histone H4 arginine 3 by reducing PRMT7 and then promotes the expression of Nanog via long noncoding RNA HULC.	Arginine	65-73	H4 clustered histone 6	Homo sapiens	54-64
31624955-9	2020	Treadmill exercise and L-arginine supplementation significantly alleviated aging-induced apoptosis with enhancing HSP-70 expression, increasing anti-oxidant enzyme activity, and suppressing inflammatory markers in the cardiac myocytes.	Arginine	23-33	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	114-120
31822509-3	2020	We identified enrichment of histone 3 dimethylation at Arg-8 (H3(Me2)R8) in the promoter regions of miR33b, miR96, and miR503.	Arginine	55-58	microRNA 33b	Homo sapiens	100-106
31999692-6	2020	The variant identified, a T to C single nucleotide polymorphism (SNP) (NC_006585.3:g.88890674T>C), is predicted to cause a tryptophan to arginine substitution in a highly conserved region of the potassium voltage-gated channel interacting protein KCNIP4.	Arginine	137-145	potassium voltage-gated channel interacting protein 4	Canis lupus familiaris	247-253
31985312-0	2021	First Detection of Hb Cenxi [beta46(CD5)Gly Arg (GGG>CGG), HBB: c.139G>C] by Capillary Electrophoresis.	Arginine	44-47	CD5 molecule	Homo sapiens	36-39
32337959-9	2020	RESULTS: LPS induced M1 polarization in BV-2 cells with increasing of CD86, iNOS and miR-155, while IL-4 induced M2 polarization in BV-2 cells with increasing of CD206, Arg and decreasing of miR-155.	Arginine	169-172	interleukin 4	Mus musculus	100-104
32240815-8	2020	In complementary studies to characterize the mechanisms by which Arg mediates endothelial barrier function, Arg silencing was found to inhibit LPS-induced disruption of adherens junctions and phosphorylation of myosin light chains (MLC).	Arginine	65-68	myosin heavy chain 14	Homo sapiens	211-217
32240815-8	2020	In complementary studies to characterize the mechanisms by which Arg mediates endothelial barrier function, Arg silencing was found to inhibit LPS-induced disruption of adherens junctions and phosphorylation of myosin light chains (MLC).	Arginine	108-111	myosin heavy chain 14	Homo sapiens	211-217
31668641-3	2019	mTORC1 activation was induced by amino acids, especially arginine and leucine, accompanied by the dynamic lysosomal localization of the mTOR and Tsc complexes.	Arginine	57-65	mechanistic target of rapamycin kinase	Mus musculus	0-4
31666677-7	2019	Furthermore, deactivation of the methyltransferase Hmt1 constitutes a molecular switch that regulates Psp2 arginine methylation status as well as its mRNA binding activity in response to starvation.	Arginine	107-115	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	51-55
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Arginine	12-20	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	90-95
31495062-5	2019	Here, we report that Sbp1 is arginine-methylated in an Hmt1-dependent manner and that methylation is enhanced upon glucose deprivation.	Arginine	29-37	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	55-59
31493399-15	2019	SARAF knockout mice developed more severe pancreatitis than control mice after administration of caerulein or L-arginine, and pancreatic acinar cells from these mice had significant increases in Ca2+ influx.	Arginine	110-120	store-operated calcium entry-associated regulatory factor	Mus musculus	0-5
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	interleukin 17A	Rattus norvegicus	115-121
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	interferon gamma	Rattus norvegicus	133-142
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	interleukin 17A	Rattus norvegicus	311-317
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	interferon gamma	Rattus norvegicus	326-335
31795337-3	2019	In addition, several tumor types have been shown to downregulate ASS-1 expression, becoming auxotrophic for arginine.	Arginine	108-116	argininosuccinate synthase 1	Homo sapiens	65-70
31250660-10	2019	Moreover, irisin upregulated UCP2 expression in the pancreas, and administration of genipin, a specific UCP2 antagonist, abolished irisin"s beneficial effects in L-arginine-induced AP.	Arginine	162-172	fibronectin type III domain containing 5	Homo sapiens	131-137
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	33-34	lysine methyltransferase 2A	Homo sapiens	122-125
31395602-10	2019	These results indicate that abolishing FLT3 arginine methylation through PRMT1 inhibition represents a promising strategy to target MLL-r ALL cells.	Arginine	44-52	lysine methyltransferase 2A	Homo sapiens	132-135
31326582-1	2019	Protein arginine methylation is a prevalent posttranslational modification and protein arginine methyltransferases 6 (PRMT6) has been identified as a suppressor of TBK1/IRF3 in human and mammals.	Arginine	8-16	TANK binding kinase 1	Homo sapiens	164-168
31475956-12	2019	CONCLUSION: This study revealed that the CSE/H2S pathway mediates the trimetazidine-induced protection of H9c2 cardiomyocytes against H/R-induced damage by inhibiting apoptosis and oxidative stress.	Arginine	136-137	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	41-44
31142511-4	2019	Mechanistically, the N-terminal SRC homology 3 domains of CIN85 interacted with the proline-arginine-rich region within the N-terminus of PHD2, thereby inhibiting PHD2 activity and HIF degradation.	Arginine	92-100	egl-9 family hypoxia-inducible factor 1	Mus musculus	138-142
31217189-7	2019	Mechanistically, PRMT1 catalyzed FLT3-ITD protein methylation at arginine 972/973, and PRMT1 promoted leukemia cell growth in an FLT3 methylation-dependent manner.	Arginine	65-73	protein arginine N-methyltransferase 1	Mus musculus	17-22
31067316-6	2019	Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B.	Arginine	250-253	RB binding protein 4, chromatin remodeling factor	Homo sapiens	147-152
31158736-4	2019	Results revealed that l-arginine increased the testosterone levels declined by T-2 toxin and up-regulated the activities and mRNA expression of P450scc, 3beta-HSD-1 and StAR down-regulated by T-2 toxin in Leydig cells.	Arginine	22-32	steroidogenic acute regulatory protein	Mus musculus	169-173
31158736-5	2019	Therefore, we concluded that l-arginine ameliorated the testosterone levels decreased by T-2 Toxin via regulating the mRNA expression and activities of P450scc, 3beta-HSD-1 and StAR in mouse Leydig cells.	Arginine	29-39	steroidogenic acute regulatory protein	Mus musculus	177-181
31199148-1	2019	Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers.	Arginine	17-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	44-70
31199148-1	2019	Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently identified in various human cancers.	Arginine	17-25	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	72-76
31304625-5	2019	Moreover, RNF34 catalyzes the K27-/K29-linked ubiquitination of MAVS at Lys 297, 311, 348, and 362 Arg, which serves as a recognition signal for NDP52-dependent autophagic degradation.	Arginine	99-102	mitochondrial antiviral signaling protein	Homo sapiens	64-68
30849508-8	2019	We used an 11-amino acid sequence from the apoB protein (ApoB11) that, when coupled with a 9-amino acid arginine linker, can transport siRNAs across the BBB to neuronal and glial cells.	Arginine	104-112	apolipoprotein B	Mus musculus	43-47
31047996-13	2019	Interestingly, the inhibitory effect of L-NAME and the potentiating effect of l-arginine on nicotine response were associated with the decrease and increase of the PFC p-CREB/CREB ratio respectively.	Arginine	78-88	cAMP responsive element binding protein 1	Rattus norvegicus	170-174
31047996-13	2019	Interestingly, the inhibitory effect of L-NAME and the potentiating effect of l-arginine on nicotine response were associated with the decrease and increase of the PFC p-CREB/CREB ratio respectively.	Arginine	78-88	cAMP responsive element binding protein 1	Rattus norvegicus	175-179
31216483-4	2019	The action of Galphaq depends on binding to three arginine residues in the N terminus of TRPM8.	Arginine	50-58	G protein subunit alpha q	Homo sapiens	14-21
30653406-7	2019	In the absence of PRMT1, increased PRMT6 specifically methylates FOXO3 at arginine 188 and 249, leading to its activation.	Arginine	74-82	protein arginine N-methyltransferase 6	Mus musculus	35-40
30896373-2	2019	The results of FTIR, 1H NMR and 13C NMR showed that the reaction occurred between primary amino group of arginine in GH and epoxy of PSiQAEp.	Arginine	105-113	gamma-glutamyl hydrolase	Homo sapiens	117-119
31137608-2	2019	Here, a missense mutation (Cys &gt; Arg) was first detected to be located in exon 3 of KCNJ12 from three Chinese cattle breeds by DNA-pool sequencing.	Arginine	36-39	ATP-sensitive inward rectifier potassium channel 12	Bos taurus	87-93
30847640-1	2019	PURPOSE: Oral L-citrulline (Cit) increases plasma L-arginine (Arg) concentration and the production of nitric oxide (NO).	Arginine	50-60	citron rho-interacting serine/threonine kinase	Homo sapiens	14-26
30847640-1	2019	PURPOSE: Oral L-citrulline (Cit) increases plasma L-arginine (Arg) concentration and the production of nitric oxide (NO).	Arginine	62-65	citron rho-interacting serine/threonine kinase	Homo sapiens	14-26
31397596-2	2019	DNA sequencing demonstrated a mutation on the HBB gene [beta40(C6)Arg Thr; HBB: c.122G&gt;C (p.Arg41Thr)], predictive of a substitution of arginine to threonine at position 40 of the beta-globin protein.	Arginine	66-69	hemoglobin subunit beta	Homo sapiens	46-49
31397596-2	2019	DNA sequencing demonstrated a mutation on the HBB gene [beta40(C6)Arg Thr; HBB: c.122G&gt;C (p.Arg41Thr)], predictive of a substitution of arginine to threonine at position 40 of the beta-globin protein.	Arginine	66-69	hemoglobin subunit beta	Homo sapiens	75-78
31397596-3	2019	This amino acid substitution involves the alpha1beta2 contact and occurs at the same position as Hb Austin [beta40(C6)Arg Ser; HBB: c.[123G&gt;C or 123G&gt;T] (p.Arg41Ser)] and Hb Athens-GA [beta40(C6)Arg Lys; HBB: c.122G&gt;A (p.Arg41Lys)], both of which show increased oxygen affinity.	Arginine	118-121	hemoglobin subunit beta	Homo sapiens	127-130
30861432-12	2019	However, TM EGF-like domain 5 was required and TM chondroitin sulfate (CS) proteoglycan sites serine 490 and serine 492 assisted in PAR2 cleavage, while thrombin preferentially cleaved at arginine 36 on PAR2"s N-terminus.	Arginine	188-196	thrombomodulin	Homo sapiens	47-49
30842273-8	2019	holarctica live vaccine strain (Ft LVS), which is known as an activator of AIM2 inflammasome, induces death in significantly more C57BL/6 mice treated with the Abl inhibitor AMN107 or c-Abl/Arg small interfering RNA than in untreated mice.	Arginine	190-193	lacking vigorous sperm	Mus musculus	35-38
30886088-5	2019	Using phylogenetic analysis and molecular dynamics simulations, it was determined that arginine at residue 37 in TNNI1 may play a critical functional role, suggesting that the variant may be pathogenic.	Arginine	87-95	troponin I1, slow skeletal type	Homo sapiens	113-118
30886105-0	2019	PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing.	Arginine	5-13	phosphatase and tensin homolog	Homo sapiens	0-4
30886105-3	2019	Mass-spectrometry analysis reveals that PTEN is dimethylated at arginine 159 (R159).	Arginine	64-72	phosphatase and tensin homolog	Homo sapiens	40-44
30886105-7	2019	Our results demonstrate that PTEN is functionally regulated by arginine methylation.	Arginine	63-71	phosphatase and tensin homolog	Homo sapiens	29-33
30886105-8	2019	We propose that PTEN arginine methylation modulates pre-mRNA alternative splicing and influences diverse physiologic processes.	Arginine	21-29	phosphatase and tensin homolog	Homo sapiens	16-20
30794434-2	2019	Specifically, the ability to increase NO production in response to the l-arginine-NO precursor l-citrulline is dependent on SNAT1 expression.	Arginine	71-81	solute carrier family 38 member 1	Homo sapiens	124-129
30797943-4	2019	We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins.	Arginine	143-151	indoleamine 2,3-dioxygenase 1	Homo sapiens	38-67
30797943-4	2019	We examined here current knowledge of indoleamine 2,3-dioxygenase 1 (IDO1) and arginase 1 (ARG1), the main enzymes catabolizing tryptophan and arginine, respectively, in organ-specific and systemic autoimmune diseases as well as in the development of autoantibodies to therapeutic proteins.	Arginine	143-151	indoleamine 2,3-dioxygenase 1	Homo sapiens	69-73
30776541-8	2019	The 91st arginine residue, known as the mammalian TLR5 activation site, was conserved in the flagellin of E. coli and other bacteria but not in EtFliC.	Arginine	9-17	toll like receptor 5	Homo sapiens	50-54
30798662-0	2019	Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.	Arginine	32-40	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	59-93
30798662-2	2019	During pregnancy, L-arginine transport by CAT-1 (cationic amino acid transporter 1), the only transporter for eNOS (endothelial nitric oxide synthase) is inhibited.	Arginine	18-28	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	42-47
30798662-2	2019	During pregnancy, L-arginine transport by CAT-1 (cationic amino acid transporter 1), the only transporter for eNOS (endothelial nitric oxide synthase) is inhibited.	Arginine	18-28	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	49-82
32254804-4	2019	The gold nanostars were further designed to be multifunctional nanoagents by labeling Raman molecules and then conjugating arginine-glycine-aspartic acid (RGD), which can serve as cancer cell-targeted SERS-imaging tags and photothermal nanoagents in both the NIR-I and NIR-II windows.	Arginine	123-131	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	201-205
30923526-11	2019	Therefore, we provided evidence that, in the context of the full length C1q protein, a key contribution to the interaction with both PTX3 and IgM is given by the B chain Arg residues that line the side of the gC1q heterotrimer, with a minor participation of a Lys residue located at the apex of gC1q.	Arginine	170-173	complement C1q A chain	Homo sapiens	72-75
30696701-0	2019	Arginine to Glutamine Variant in Olfactomedin Like 3 (OLFML3) Is a Candidate for Severe Goniodysgenesis and Glaucoma in the Border Collie Dog Breed.	Arginine	0-8	olfactomedin like 3	Canis lupus familiaris	33-52
30696701-0	2019	Arginine to Glutamine Variant in Olfactomedin Like 3 (OLFML3) Is a Candidate for Severe Goniodysgenesis and Glaucoma in the Border Collie Dog Breed.	Arginine	0-8	olfactomedin like 3	Canis lupus familiaris	54-60
30610061-8	2019	Mechanistically, Arg-II appears to cause OA cartilage destruction at least partly by upregulating the expression of matrix-degrading enzymes (matrix metalloproteinase 3 [MMP3] and MMP13) in chondrocytes via the nuclear factor (NF)-kappaB pathway.	Arginine	17-20	matrix metallopeptidase 3	Mus musculus	142-168
30610061-8	2019	Mechanistically, Arg-II appears to cause OA cartilage destruction at least partly by upregulating the expression of matrix-degrading enzymes (matrix metalloproteinase 3 [MMP3] and MMP13) in chondrocytes via the nuclear factor (NF)-kappaB pathway.	Arginine	17-20	matrix metallopeptidase 3	Mus musculus	170-174
30182157-7	2019	The L-arginine/ADMA ratio was lower (160 +- 51 vs. 194 +- 38, p = 0.028) after CB2 than CFRF ablation.	Arginine	4-14	cannabinoid receptor 2	Homo sapiens	79-82
30808864-1	2019	Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC).	Arginine	13-21	argininosuccinate synthase 1	Homo sapiens	172-176
30808864-1	2019	Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC).	Arginine	13-21	ornithine transcarbamylase	Homo sapiens	182-208
30808864-1	2019	Depletion of arginine induced by PEGylated arginase 1 (ARG1) (BCT-100) has shown anticancer effects in arginine auxotrophic cancers that lack argininosuccinate synthetase (ASS1) and ornithine transcarbamylase (OTC).	Arginine	13-21	ornithine transcarbamylase	Homo sapiens	210-213
30742606-7	2019	Two consecutive arginine codons in the conserved domain of orf34 provide a third level of speF regulation.	Arginine	16-24	family with sequence similarity 120C	Homo sapiens	59-64
30742606-8	2019	Uninterrupted translation of orf34 under conditions of high arginine allows the formation of a speF mRNA structure that is degraded by RNase G, whereas ribosome pausing at the consecutive arginine codons in the absence of arginine enables the formation of an alternative structure that is resistant to RNase G. Thus, the rate of ribosome progression during translation of the upstream ORF influences the dynamics of speF mRNA folding and putrescine production.	Arginine	60-68	family with sequence similarity 120C	Homo sapiens	29-34
30742606-8	2019	Uninterrupted translation of orf34 under conditions of high arginine allows the formation of a speF mRNA structure that is degraded by RNase G, whereas ribosome pausing at the consecutive arginine codons in the absence of arginine enables the formation of an alternative structure that is resistant to RNase G. Thus, the rate of ribosome progression during translation of the upstream ORF influences the dynamics of speF mRNA folding and putrescine production.	Arginine	188-196	family with sequence similarity 120C	Homo sapiens	29-34
30742606-8	2019	Uninterrupted translation of orf34 under conditions of high arginine allows the formation of a speF mRNA structure that is degraded by RNase G, whereas ribosome pausing at the consecutive arginine codons in the absence of arginine enables the formation of an alternative structure that is resistant to RNase G. Thus, the rate of ribosome progression during translation of the upstream ORF influences the dynamics of speF mRNA folding and putrescine production.	Arginine	188-196	family with sequence similarity 120C	Homo sapiens	29-34
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	10-18	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	50-83
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	10-18	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	85-90
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	102-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	50-83
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	102-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	85-90
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	102-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	50-83
30545920-3	2019	Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival.	Arginine	102-110	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	85-90
30682707-0	2019	Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans.	Arginine	0-8	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	24-29
30682707-4	2019	Here, we found arginines 484 and 516 (R484/R516) of SKN-1 were asymmetrically dimethylated by PRMT-1.	Arginine	15-24	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	52-57
30682707-6	2019	Consequently, asymmetrical dimethylation of arginines on SKN-1 was elevated.	Arginine	44-53	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	57-62
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	0-8	Ras related GTP binding A	Homo sapiens	196-202
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	84-92	Ras related GTP binding A	Homo sapiens	196-202
30352320-5	2019	We found that ITGA5 is highly expressed in strongly migratory and invasive TNBC cells as well as their lung metastatic foci, which rationalizes active-targeted drug delivery to TNBC cells via ITGA5 ligands such as a commercialized ligand-RGD motif (Arg-Gly-Asp).	Arginine	249-252	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	14-19
30352320-5	2019	We found that ITGA5 is highly expressed in strongly migratory and invasive TNBC cells as well as their lung metastatic foci, which rationalizes active-targeted drug delivery to TNBC cells via ITGA5 ligands such as a commercialized ligand-RGD motif (Arg-Gly-Asp).	Arginine	249-252	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	192-197
30165510-1	2019	In this study the chiral selectivity of l-undecyl-leucine (und-leu) for binapthyl derivatives was examined with the use of arginine and sodium counterions at pH"s ranging from 7 to 11.	Arginine	123-131	collagen type XIV alpha 1 chain	Homo sapiens	42-45
30165510-3	2019	The data indicate that und-leu has significantly improved chiral selectivity toward 1,1"-binaphthyl-2,2"-diyl hydrogenphosphate (BNP) enantiomers in the presence of arginine counterions in comparison to sodium and that, at least in the case of this study, the enantiomeric form of the arginine did not appear to play a role in the chiral selectivity.	Arginine	165-173	collagen type XIV alpha 1 chain	Homo sapiens	23-26
30165510-3	2019	The data indicate that und-leu has significantly improved chiral selectivity toward 1,1"-binaphthyl-2,2"-diyl hydrogenphosphate (BNP) enantiomers in the presence of arginine counterions in comparison to sodium and that, at least in the case of this study, the enantiomeric form of the arginine did not appear to play a role in the chiral selectivity.	Arginine	285-293	collagen type XIV alpha 1 chain	Homo sapiens	23-26
30495919-3	2018	Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4).	Arginine	56-64	glutathione peroxidase 4	Homo sapiens	229-264
30495919-3	2018	Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4).	Arginine	56-64	glutathione peroxidase 4	Homo sapiens	266-270
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 1 receptor	Homo sapiens	135-139
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 1 receptor	Homo sapiens	172-176
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 1 receptor	Homo sapiens	172-176
30566530-4	2018	HBc s interactions with nucleic acids are mediated by an arginine-rich C terminal domain (CTD) with intrinsically strong non-specific RNA binding activity.	Arginine	57-65	keratin 88, pseudogene	Homo sapiens	0-3
30619275-11	2018	We found L-arginine supplementation enhanced Th1 immune response by increasing IFN-gamma production.	Arginine	9-19	interferon gamma	Rattus norvegicus	79-88
30619275-12	2018	Both the L-arginine and L-citrulline therapy can modulate regulatory T-cell (Treg) immune effects by increasing the IL-10 level.	Arginine	9-19	interleukin 10	Rattus norvegicus	116-121
30376629-4	2018	Transcellular transport studies showed that prazosin, [14C]l-lactate, [3H]l-arginine, and [3H]l-glutamate (substrates of BCRP, MCT1, CAT1, and GLAST, respectively) were transported asymmetrically across the hiPS-BMEC monolayer.	Arginine	74-84	BCR pseudogene 1	Homo sapiens	121-125
30191331-8	2018	The expression of Gls in the kidney was increased by the addition of 1.5% Arg to 3% Lys diet (P &lt; 0.05).	Arginine	74-77	glutaminase	Rattus norvegicus	18-21
29107336-4	2018	Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG.	Arginine	81-84	citron rho-interacting serine/threonine kinase	Homo sapiens	14-17
29107336-4	2018	Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG.	Arginine	81-84	citron rho-interacting serine/threonine kinase	Homo sapiens	120-123
29107336-4	2018	Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG.	Arginine	81-84	citron rho-interacting serine/threonine kinase	Homo sapiens	120-123
29107336-4	2018	Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG.	Arginine	201-204	citron rho-interacting serine/threonine kinase	Homo sapiens	14-17
30257829-5	2018	To reveal the mechanism of this interaction, we used computational simulation-based docking studies and identified that the carboxyl tail of 15d-PGJ2 could stabilize the binding of 15d-PGJ2 to eIF4A through arginine 295 of eIF4A, which is the first suggestion that the 15d-PGJ2 tail plays a physiological role.	Arginine	207-215	eukaryotic translation initiation factor 4A2	Homo sapiens	193-198
30257829-5	2018	To reveal the mechanism of this interaction, we used computational simulation-based docking studies and identified that the carboxyl tail of 15d-PGJ2 could stabilize the binding of 15d-PGJ2 to eIF4A through arginine 295 of eIF4A, which is the first suggestion that the 15d-PGJ2 tail plays a physiological role.	Arginine	207-215	eukaryotic translation initiation factor 4A2	Homo sapiens	223-228
30248409-11	2018	This finding strongly suggests that Arg97 in LbNTD and more generally the conserved arginine residue in parasite Hsp90s are not exploitable for the development of selective inhibitors.	Arginine	84-92	heat shock protein 90 alpha family class A member 1	Homo sapiens	113-118
30236872-0	2018	Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1/AMPK pathway.	Arginine	0-8	sirtuin 1	Mus musculus	96-101
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	sirtuin 1	Mus musculus	143-151
30236872-2	2018	Our data showed that dietary supplementation of arginine in mice significantly up-regulated the slow myosin heavy chain (MyHC), troponin I-SS, sirtuin1 (Sirt1) and peroxisome proliferator activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expressions, as well as significantly down-regulated the fast MyHC protein expression.	Arginine	48-56	sirtuin 1	Mus musculus	153-158
30236872-7	2018	Finally, we showed that inhibition of Sirt1 expression by EX527 attenuated arginine-induced increase in the protein levels of phospho-AMPK and slow MyHC, the mRNA level of nitric oxide synthase (NOS) and the contents of NOS and NO, as well as decrease in fast MyHC protein level.	Arginine	75-83	sirtuin 1	Mus musculus	38-43
30236872-8	2018	Together, our findings indicated that arginine promotes skeletal muscle fiber type switching from fast-twitch to slow-twitch via Sirt1/AMPK pathway.	Arginine	38-46	sirtuin 1	Mus musculus	129-134
30425418-7	2018	Application of the NO donor and Arg also enhanced the glyoxalase system and reduced the MG content by increasing the activities of the glyoxalase system enzymes (Gly I and Gly II), which restored the leaf RWC and further increased the Pro content under drought stress conditions.	Arginine	32-35	glyoxalase I	Homo sapiens	162-178
30411001-10	2018	In the active conformations, a pi-cation interaction between essential arginine and tryptophan residues, which was characterized by a fluorescence-measured red shift and modeled by molecular dynamics, was also shown to be a contributor to the stability of Galpha subunits.	Arginine	71-79	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	256-262
30375398-7	2018	Further investigation revealed that PANDAR-reduced cisplatin sensitivity was likely or partly due to the PANDAR-binding protein SFRS2 (arginine/serine-rich 2), a splicing factor with the ability to negative regulate p53 and its phosphorylation at Serine 15 (Ser15).	Arginine	135-143	promoter of CDKN1A antisense DNA damage activated RNA	Homo sapiens	36-42
30375398-7	2018	Further investigation revealed that PANDAR-reduced cisplatin sensitivity was likely or partly due to the PANDAR-binding protein SFRS2 (arginine/serine-rich 2), a splicing factor with the ability to negative regulate p53 and its phosphorylation at Serine 15 (Ser15).	Arginine	135-143	promoter of CDKN1A antisense DNA damage activated RNA	Homo sapiens	105-111
30393775-1	2018	Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.	Arginine	10-18	argininosuccinate synthase 1	Homo sapiens	54-82
30393775-1	2018	Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.	Arginine	10-18	argininosuccinate synthase 1	Homo sapiens	84-88
30393775-1	2018	Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.	Arginine	147-155	argininosuccinate synthase 1	Homo sapiens	54-82
30393775-1	2018	Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.	Arginine	147-155	argininosuccinate synthase 1	Homo sapiens	84-88
30206632-2	2018	Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation.	Arginine	153-163	interleukin 4	Mus musculus	30-43
30206632-2	2018	Arginase (Arg)-1 expressed in interleukin-4 (IL-4)-induced M2 microglia reduces nitric oxide (NO) production by competing with inducible NO synthase for l-arginine, which contributes to the attenuation of brain inflammation.	Arginine	153-163	interleukin 4	Mus musculus	45-49
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interleukin 1 alpha	Homo sapiens	18-27
30029328-9	2018	The abundance of several other known ARG or metal resistance genes (MRGs), including corA and arsB, also increased as the concentrations of TCS increased.	Arginine	37-40	arylsulfatase B	Homo sapiens	94-98
29718707-3	2018	Herein, we report that in mice that are deficient in Arg-II (Arg-II-/-), total and membrane-associated aquaporin-2 (AQP2) protein levels were significantly higher compared with wild-type (WT) controls.	Arginine	53-56	aquaporin 2	Mus musculus	103-114
29718707-3	2018	Herein, we report that in mice that are deficient in Arg-II (Arg-II-/-), total and membrane-associated aquaporin-2 (AQP2) protein levels were significantly higher compared with wild-type (WT) controls.	Arginine	53-56	aquaporin 2	Mus musculus	116-120
29718707-3	2018	Herein, we report that in mice that are deficient in Arg-II (Arg-II-/-), total and membrane-associated aquaporin-2 (AQP2) protein levels were significantly higher compared with wild-type (WT) controls.	Arginine	61-64	aquaporin 2	Mus musculus	103-114
29718707-3	2018	Herein, we report that in mice that are deficient in Arg-II (Arg-II-/-), total and membrane-associated aquaporin-2 (AQP2) protein levels were significantly higher compared with wild-type (WT) controls.	Arginine	61-64	aquaporin 2	Mus musculus	116-120
29718707-5	2018	Effects of water deprivation on AQP2 were stronger in Arg-II-/- mice than in WT mice.	Arginine	54-57	aquaporin 2	Mus musculus	32-36
29718707-8	2018	Although total AQP2 and phosphorylated AQP2-S256 levels (mediated by PKA) in kidneys under water deprivation conditions were significantly higher in Arg-II-/- mice compared with WT animals, there is no difference in the ratio of AQP2-S256:AQP2.	Arginine	149-152	aquaporin 2	Mus musculus	39-43
29718707-8	2018	Although total AQP2 and phosphorylated AQP2-S256 levels (mediated by PKA) in kidneys under water deprivation conditions were significantly higher in Arg-II-/- mice compared with WT animals, there is no difference in the ratio of AQP2-S256:AQP2.	Arginine	149-152	aquaporin 2	Mus musculus	39-43
29300374-0	2018	Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations.	Arginine	103-111	actin alpha 2, smooth muscle	Homo sapiens	97-102
29300374-1	2018	PURPOSE: Smooth muscle dysfunction syndrome (SMDS) due to heterozygous ACTA2 arginine 179 alterations is characterized by patent ductus arteriosus, vasculopathy (aneurysm and occlusive lesions), pulmonary arterial hypertension, and other complications in smooth muscle-dependent organs.	Arginine	77-85	actin alpha 2, smooth muscle	Homo sapiens	71-76
30091165-0	2018	l-arginine protects against oxidative damage induced by T-2 toxin in mouse Leydig cells.	Arginine	0-10	brachyury 2	Mus musculus	56-59
30091165-1	2018	To explore the protective mechanism of l-arginine against T-2 toxin-induced oxidative damage in mouse Leydig cells, Leydig cells were isolated and cultured with control, T-2 toxin (10 nM), l-arginine (0.25, 0.5, and 1.0 mM), and T-2 toxin (10 nM T-2 toxin) with l-arginine (0.25, 0.5, or 1.0 mM) for 24 hours.	Arginine	39-49	brachyury 2	Mus musculus	58-61
30091165-4	2018	However, l-arginine reduced T-2 toxin-induced oxidative damage and tended to maintain normal levels.	Arginine	9-19	brachyury 2	Mus musculus	28-31
30091165-6	2018	Collectively, l-arginine, due to its antioxidative ability, could ameliorate T-2 toxin-induced cytotoxicities in mouse Leydig cells by regulating oxidative stress.	Arginine	14-24	brachyury 2	Mus musculus	77-80
30128637-3	2018	Lys 75 and Arg 73 of Cotl1 play an important role in binding F-actin; when they are mutated to Glu, Cotl1 cannot bind F-actin, called as a non-actin-binding mutant (ABM).	Arginine	11-14	coactosin-like 1 (Dictyostelium)	Mus musculus	21-26
30456387-3	2018	Arginines within an array in the highly methylated RNA-binding protein synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) were experimentally shown to function in concert, providing a tunable protein interaction interface.	Arginine	0-9	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	71-128
30456387-3	2018	Arginines within an array in the highly methylated RNA-binding protein synaptotagmin binding cytoplasmic RNA interacting protein (SYNCRIP) were experimentally shown to function in concert, providing a tunable protein interaction interface.	Arginine	0-9	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	130-137
30456387-6	2018	This study highlights how highly repetitive modifiable amino acid arrays in low structural complexity regions can provide regulatory platforms, with SYNCRIP as an extreme example how arginine methylation leverages these disordered sequences to mediate cellular interactions.	Arginine	183-191	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	149-156
30151521-9	2018	In the in vitro experiment, 6-G reset the IL-4-induced arginase+ M2 cells toward iNOS+ M1 cells and exhibited reduced levels of arginase 1 and ROS and elevated levels of L-arginine and NO.	Arginine	170-180	interleukin 4	Mus musculus	42-46
30181260-7	2018	Upon arginine binding, SLC38A9 converts RagA from the GDP- to the GTP-loaded state, and therefore activates the Rag GTPase heterodimer.	Arginine	5-13	Ras related GTP binding A	Homo sapiens	40-44
30344909-1	2018	Protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine to citrulline within target proteins.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
29987187-1	2018	Peptidylarginine deiminase (PAD) enzymes convert histone arginine residues into citrulline to modulate chromatin organization and gene expression.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
30194083-3	2018	IDH1 and IDH2 mutations are restricted to specific arginine residues in the active site of the enzymes and are gain-of-function, i.e. they confer a neomorphic enzyme activity resulting in the accumulation of D-2-hydroxyglutarate (2-HG).	Arginine	51-59	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
30158868-1	2018	It is well known that arginase II leads to decreased synthesis of nitric oxide (NO) by competing with endothelial nitric oxide synthase (eNOS) for their same substrate L-arginine.	Arginine	168-178	nitric oxide synthase 3, endothelial cell	Mus musculus	102-135
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	141-149	argininosuccinate synthase 1	Homo sapiens	43-71
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	141-149	argininosuccinate synthase 1	Homo sapiens	73-77
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	141-149	ornithine transcarbamylase	Homo sapiens	83-109
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	141-149	ornithine transcarbamylase	Homo sapiens	111-114
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	176-184	argininosuccinate synthase 1	Homo sapiens	43-71
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	176-184	argininosuccinate synthase 1	Homo sapiens	73-77
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	176-184	ornithine transcarbamylase	Homo sapiens	83-109
30108309-1	2018	Tumors deficient in the urea cycle enzymes argininosuccinate synthase-1 (ASS1) and ornithine transcarbamylase (OTC) are unable to synthesize arginine and can be targeted using arginine-deprivation therapy.	Arginine	176-184	ornithine transcarbamylase	Homo sapiens	111-114
30108309-5	2018	Pegylated arginine deiminase (ADI-PEG20), which degrades arginine to citrulline and ammonia, affects growth of ASS1-negative cells, whereas recombinant human arginase-1 (rhArg1peg5000), which degrades arginine into urea and ornithine, is effective against a broad spectrum of OTC-negative CRC cell lines.	Arginine	10-18	argininosuccinate synthase 1	Homo sapiens	111-115
30108309-5	2018	Pegylated arginine deiminase (ADI-PEG20), which degrades arginine to citrulline and ammonia, affects growth of ASS1-negative cells, whereas recombinant human arginase-1 (rhArg1peg5000), which degrades arginine into urea and ornithine, is effective against a broad spectrum of OTC-negative CRC cell lines.	Arginine	10-18	ornithine transcarbamylase	Homo sapiens	276-279
30062355-0	2018	Experimental and theoretical investigations of infrared multiple photon dissociation spectra of arginine complexes with Zn2+ and Cd2.	Arginine	96-104	CD2 molecule	Homo sapiens	129-132
30062355-1	2018	Arginine (Arg) complexes with Zn2+ and Cd2+ were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light from a free electron laser.	Arginine	0-8	CD2 molecule	Homo sapiens	39-42
30062355-1	2018	Arginine (Arg) complexes with Zn2+ and Cd2+ were examined by infrared multiple photon dissociation (IRMPD) action spectroscopy using light from a free electron laser.	Arginine	0-3	CD2 molecule	Homo sapiens	39-42
30054507-4	2018	This study examined the role of HDAC8, which is the most distinct isoform of class I, in the hypoxia mimetic cobalt- and H/R-induced cytotoxicity of human proximal tubular HK-2 cells.	Arginine	123-124	histone deacetylase 8	Homo sapiens	32-37
30054507-9	2018	Collectively, this study shows that HDAC8 inhibits cytotoxicity induced by cobalt and H/R, in part, through suppressing DRP1 expression and mitochondrial fission.	Arginine	88-89	histone deacetylase 8	Homo sapiens	36-41
30054507-9	2018	Collectively, this study shows that HDAC8 inhibits cytotoxicity induced by cobalt and H/R, in part, through suppressing DRP1 expression and mitochondrial fission.	Arginine	88-89	dynamin 1 like	Homo sapiens	120-124
30036999-0	2018	The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.	Arginine	16-24	heat shock protein family B (small) member 1	Homo sapiens	110-115
30036999-4	2018	Substitution of this arginine with an alanine induced changes in thermal stability and/or intrinsic fluorescence of the related HspB1 and HspB8, but yielded only modest changes in the same biophysical properties of HspB4, HspB5, and HspB6 which together belong to another clade of vertebrate sHsps.	Arginine	21-29	heat shock protein family B (small) member 1	Homo sapiens	128-133
30036999-5	2018	Removal of the positively charged Arg side chain resulted in destabilization of the large oligomers of HspB1 and formation of smaller size oligomers of HspB5.	Arginine	34-37	heat shock protein family B (small) member 1	Homo sapiens	103-108
29775649-3	2018	B1R and B2R are induced by proinflammatory cytokines and their activation by bradykinin (BK: B2R agonist) or des-arg-kallidin (DAKD: B1R agonist), induces NO and PGI2 production which is key for reducing collagen I levels.	Arginine	112-116	bradykinin receptor B2	Homo sapiens	8-11
29902001-6	2018	The chemical modification of alpha-glucosidase verified the results of the computer simulation that the order of importance of the four amino acid residues in the binding process was His &gt; Tyr &gt; Lys &gt; Arg.	Arginine	210-213	sucrase-isomaltase	Homo sapiens	29-46
29996845-0	2018	The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag.	Arginine	14-22	Pr76 polyprotein precursor	Rous sarcoma virus	133-136
29996845-3	2018	In the case of Foamy viruses, genome encapsidation is mediated by Gag C-terminal domain (CTD), which harbors three clusters of glycine and arginine residues named GR boxes (GRI-III).	Arginine	139-147	Pr76 polyprotein precursor	Rous sarcoma virus	66-69
29996845-6	2018	In contrast, both the entire Gag CTD and the isolated GRII box, which contains the chromatin-binding motif, target the nucleolus exclusively upon mutation of the evolutionary conserved arginine residue at position 540 (R540), which is a key determinant of FV Gag chromatin tethering.	Arginine	185-193	Pr76 polyprotein precursor	Rous sarcoma virus	29-32
29996845-6	2018	In contrast, both the entire Gag CTD and the isolated GRII box, which contains the chromatin-binding motif, target the nucleolus exclusively upon mutation of the evolutionary conserved arginine residue at position 540 (R540), which is a key determinant of FV Gag chromatin tethering.	Arginine	185-193	Pr76 polyprotein precursor	Rous sarcoma virus	259-262
29760200-6	2018	We report here a third receptor that is regulated by arginine methylation, the Caenorhabditis elegans SER-2 tyramine receptor.	Arginine	53-61	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	102-107
29760200-7	2018	We show that arginines within a putative methylation motif in the third intracellular loop of SER-2 are methylated by PRMT5 in vitro Our data also suggest that this modification enhances SER-2 signaling in vivo to modulate animal behavior.	Arginine	13-22	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	94-99
29760200-7	2018	We show that arginines within a putative methylation motif in the third intracellular loop of SER-2 are methylated by PRMT5 in vitro Our data also suggest that this modification enhances SER-2 signaling in vivo to modulate animal behavior.	Arginine	13-22	G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2	Caenorhabditis elegans	187-192
29679289-5	2018	OBJECTIVE: To clarify the exact mechanisms involved, the activation of CA1 nitric oxide (NO) signaling pathway by L-arginine (a nitric oxide precursor) on the interaction between tramadol and MK-801 in memory retrieval was examined.	Arginine	114-124	carbonic anhydrase 1	Mus musculus	71-74
29852068-4	2018	Crystallography revealed that this inhibitor induces an unprecedented binding pocket by interactions of a nitrile substituent with arginine residues in JAK3.	Arginine	131-139	Janus kinase 3	Homo sapiens	152-156
32255154-3	2018	Herein, an arginine-functionalized polyhedral oligomeric silsesquioxane (POSS) framework, PP-x-Arg (x = 0, 1, 2, ... denotes the amount of salt in preparation), was developed by combining salt-templated thermal polymerization of POSS and pyromellitic dianhydride (PMDA) with post-modification using arginine.	Arginine	11-19	protein phosphatase 4 catalytic subunit	Homo sapiens	90-94
29322360-2	2018	Importance of the arginine is also demonstrated in studies where a single mutation (Arg   Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis".	Arginine	18-26	cathepsin K	Homo sapiens	114-125
29322360-2	2018	Importance of the arginine is also demonstrated in studies where a single mutation (Arg   Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis".	Arginine	18-26	cathepsin K	Homo sapiens	127-132
29322360-2	2018	Importance of the arginine is also demonstrated in studies where a single mutation (Arg   Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis".	Arginine	84-87	cathepsin K	Homo sapiens	114-125
29322360-2	2018	Importance of the arginine is also demonstrated in studies where a single mutation (Arg   Trp) in human lysosomal cathepsin K (hCTSK) is linked to a bone-related genetic disorder "Pycnodysostosis".	Arginine	84-87	cathepsin K	Homo sapiens	127-132
29322360-3	2018	In the present study, we have characterized in vitro Arg   Trp mutant of hCTSK and the same mutant of hCTSL.	Arginine	53-56	cathepsin K	Homo sapiens	73-78
29878271-1	2018	Background: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production.	Arginine	136-144	argininosuccinate synthetase 1	Mus musculus	43-71
29878271-1	2018	Background: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production.	Arginine	136-144	argininosuccinate synthetase 1	Mus musculus	73-77
29604058-4	2018	Alignment of the voltage sensor of Shaker K+ channels with the entire TRPM3 sequence revealed the highest degree of similarity in the putative S4 region of TRPM3, and suggested that only one single gating charge arginine (R2) in the putative S4 region is conserved.	Arginine	212-220	transient receptor potential cation channel subfamily M member 3	Homo sapiens	70-75
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	lysine methyltransferase 2A	Homo sapiens	113-117
29435722-8	2018	Addition of 50-500 mumol/L Arg to culture medium increased (P &lt; 0.05) the proliferation of PMECs and the synthesis of proteins (including beta-casein and alpha-lactalbumin), while reducing the rates of proteolysis, in a dose-dependent manner.	Arginine	27-30	casein beta	Homo sapiens	141-152
29577948-4	2018	After 14 days feeding, the mRNA levels and protein expressions of Keap1 and Cul3 were gradually reduced by increasing l-arginine intake, resulting that the nuclear factor Nrf2 was activated.	Arginine	118-128	cullin 3	Rattus norvegicus	76-80
29121483-0	2018	Effects of N-carbamylglutamate and L-arginine on gonadotrophin-releasing hormone (GnRH) gene expression and secretion in GT1-7 cells.	Arginine	35-45	gonadotropin releasing hormone 1	Mus musculus	49-80
29121483-0	2018	Effects of N-carbamylglutamate and L-arginine on gonadotrophin-releasing hormone (GnRH) gene expression and secretion in GT1-7 cells.	Arginine	35-45	gonadotropin releasing hormone 1	Mus musculus	82-86
29121483-2	2018	The objectives of the present study were to evaluate the effects of NCG and ARG on GT1-7 cell gonadotrophin-releasing hormone (GnRH) secretion, gene expression and cell proliferation.	Arginine	76-79	gonadotropin releasing hormone 1	Mus musculus	94-125
29121483-4	2018	For GnRH secretion and cell proliferation, GT1-7 cells were more sensitive to NCG than ARG.	Arginine	87-90	gonadotropin releasing hormone 1	Mus musculus	4-8
29121483-6	2018	ARG treatment decreased GnRH secretion after 24h (P&lt;0.05), whereas it had no effect after 12h.	Arginine	0-3	gonadotropin releasing hormone 1	Mus musculus	24-28
29121483-8	2018	High concentrations of NCG (1.0mM) and ARG (4.0mM) inhibited (P&lt;0.05) GnRH and nNOS mRNA abundance in GT1-7 cells.	Arginine	39-42	gonadotropin releasing hormone 1	Mus musculus	73-77
29121483-9	2018	ARG treatment decreased Kiss1 and increased ERalpha mRNA abundance.	Arginine	0-3	estrogen receptor 1 (alpha)	Mus musculus	44-51
29121483-10	2018	Thus, high concentrations of NCG (1.0mM) and ARG (4.0mM) may act both directly and indirectly to regulate GnRH neuron function by downregulating genes related to GnRH synthesis and secretion to slow GnRH production while stimulating GT1-7 cell proliferation.	Arginine	45-48	gonadotropin releasing hormone 1	Mus musculus	106-110
29854093-5	2018	L-NAME, an NOS inhibitor, decreased NO concentrations within cells and abolished the stimulatory effect of L-Arg on protein synthesis and the phosphorylation of mTOR and p70S6K.	Arginine	107-112	mechanistic target of rapamycin kinase	Mus musculus	161-165
29854093-7	2018	Blocking mTOR with rapamycin abolished the stimulatory effect of both L-Arg and SNP on protein synthesis and p70S6K phosphorylation.	Arginine	70-75	mechanistic target of rapamycin kinase	Mus musculus	9-13
29854093-8	2018	These results indicate that L-Arg stimulates protein synthesis via the activation of the mTOR (Thr 2446)/p70S6K signaling pathway in an NO-dependent manner.	Arginine	28-33	mechanistic target of rapamycin kinase	Mus musculus	89-93
29595256-8	2018	Furthermore, the protein abundance of ZO-1 and claudin-1 in the ileum was greater ( p &lt; 0.05) in the IUGR + 1% Arg or 0.1% NCG lambs.	Arginine	114-117	claudin-1	Ovis aries	47-56
29628309-4	2018	Unexpectedly, JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding.	Arginine	102-110	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	14-19
29628309-4	2018	Unexpectedly, JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding.	Arginine	102-110	mediator complex subunit 12	Homo sapiens	37-42
29628309-4	2018	Unexpectedly, JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding.	Arginine	102-110	mediator complex subunit 12	Homo sapiens	84-89
29641999-4	2018	We report that JMJD1B, previously identified as a lysine demethylase for H3K9me2, mediates arginine demethylation of H4R3me2s and its intermediate, H4R3me1.	Arginine	91-99	KDM3B lysine (K)-specific demethylase 3B	Mus musculus	15-21
29641999-8	2018	Altogether, our study demonstrates that demethylase-mediated active arginine demethylation process exists in eukaryotes and that JMJD1B demethylates both H4R3me2s and H3K9me2 for epigenetic programming during hematopoiesis.	Arginine	68-76	KDM3B lysine (K)-specific demethylase 3B	Mus musculus	129-135
29530492-4	2018	Similarly Intracerebroventricular injection of l-arginine (25-100 mug/rat), a biosynthetic precursor of agmatine and arcaine (50 mug -100 mug/rat), an agmatinase inhibitor, also increased the step through latency during retrieval test in nicotine withdrawn animals.	Arginine	47-57	agmatinase	Rattus norvegicus	151-161
29568320-3	2018	The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein.	Arginine	28-36	H3 histone pseudogene 16	Homo sapiens	246-249
29564399-12	2018	Instead, Dal81 represses arginine synthesis during growth under preferred nitrogen conditions.	Arginine	25-33	Dal81p	Saccharomyces cerevisiae S288C	9-14
29721066-1	2018	Rational: In a subset of cancers, arginine auxotrophy occurs due to the loss of expression of argininosuccinate synthetase 1 (ASS1).	Arginine	34-42	argininosuccinate synthase 1	Homo sapiens	94-124
29037682-0	2018	l-Lysine and l-arginine inhibit myosin aggregation and interact with acidic amino acid residues of myosin: The role in increasing myosin solubility.	Arginine	13-23	myosin heavy chain 14	Homo sapiens	32-38
29037682-0	2018	l-Lysine and l-arginine inhibit myosin aggregation and interact with acidic amino acid residues of myosin: The role in increasing myosin solubility.	Arginine	13-23	myosin heavy chain 14	Homo sapiens	99-105
29037682-1	2018	The objective of this paper is to investigate the potential affecting mechanisms of l-lysine (Lys)/l-arginine (Arg) on myosin solubility.	Arginine	99-109	myosin heavy chain 14	Homo sapiens	119-125
29037682-1	2018	The objective of this paper is to investigate the potential affecting mechanisms of l-lysine (Lys)/l-arginine (Arg) on myosin solubility.	Arginine	111-114	myosin heavy chain 14	Homo sapiens	119-125
29037682-2	2018	The results showed that both Lys and Arg increased the solubility of myosin at the examined pH values.	Arginine	37-40	myosin heavy chain 14	Homo sapiens	69-75
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Arginine	27-30	myosin heavy chain 14	Homo sapiens	66-72
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Arginine	27-30	myosin heavy chain 14	Homo sapiens	155-161
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Arginine	27-30	myosin heavy chain 14	Homo sapiens	155-161
29037682-3	2018	Additionally, both Lys and Arg decreased the hydrodynamic size of myosin but increased the hydration capacity (HC), the surface aromatic hydrophobicity of myosin, the surface tension of the myosin solution and the absolute transfer free energy (TFE) of the major amino acids that constitute myosin.	Arginine	27-30	myosin heavy chain 14	Homo sapiens	155-161
29037682-4	2018	The results indicate that the properties of Lys or Arg that result in an inhibition of myosin aggregation and an interaction with hydrophobic amino acid residues may play important roles in increasing the myosin solubility.	Arginine	51-54	myosin heavy chain 14	Homo sapiens	87-93
29080813-8	2018	RESULTS: Arg inhibited the TLR4 downstream pathway by binding to TLR4 and consequently activated Janus kinase 2/signal transducer and activator of transcription 5 signaling pathway.	Arginine	9-12	Janus kinase 2	Mus musculus	97-111
29382206-3	2018	Owing to a mutation in an important arginine residue in the catalytic pocket, mutant IDH1 catalyzes the production of 2-hydroxyglutarate (2-HG) instead of its wild type product alpha-ketoglutarate (alpha-KG), which is involved in multiple cellular pathways involving the hydroxylation of proteins, ribonucleic acid, and deoxyribose nucleic acid (DNA).	Arginine	36-44	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	85-89
29410783-3	2018	In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine.	Arginine	26-34	ornithine decarboxylase	Ovis aries	129-133
29410783-3	2018	In the classical pathway, arginine (Arg) is transformed into ornithine, which is then decarboxylated by ornithine decarboxylase (ODC1) to produce putrescine which is the substrate for the production of spermidine and spermine.	Arginine	36-39	ornithine decarboxylase	Ovis aries	129-133
29351814-10	2018	CONCLUSIONS: Our results demonstrate a novel and unexpected role for SETDB1 in protecting IAPs from TET2-dependent histone arginine demethylation.	Arginine	123-131	tet methylcytosine dioxygenase 2	Mus musculus	100-104
29196264-3	2018	The effects of APC on endothelial cells may be reproduced by TR47, a PAR1-based peptide that mimics the novel N-terminus of PAR1 generated upon cleavage at Arg-46 by APC.	Arginine	156-159	coagulation factor II (thrombin) receptor	Mus musculus	69-73
29196264-3	2018	The effects of APC on endothelial cells may be reproduced by TR47, a PAR1-based peptide that mimics the novel N-terminus of PAR1 generated upon cleavage at Arg-46 by APC.	Arginine	156-159	coagulation factor II (thrombin) receptor	Mus musculus	124-128
29307398-6	2018	TP53 codon 72 (arginine) exhibits higher rates of apoptosis and leukemia inhibitory factor expression, whereas the C allele (proline) reduces leukemia inhibitory factor expression.	Arginine	15-23	LIF interleukin 6 family cytokine	Homo sapiens	64-90
29115630-7	2018	TIPE2 overexpression accelerated IL-4 induced M2 polarization by dampening mTORC1 activation via the accelerated process of arginine to urea.	Arginine	124-132	interleukin 4	Mus musculus	33-37
29292255-5	2017	RESULTS: Among the 9 protein arginine methylation enzyme family genes that were tissue?specifically expressed in the DRG, Prmt2 and Prmt3 showed the highest and Prmt6 showed the lowest basal expression.	Arginine	29-37	protein arginine N-methyltransferase 6	Mus musculus	161-166
29233899-4	2017	The targeting of GBP1 to cytosolic bacteria, via a unique triple-arginine motif present in its C terminus, promotes the corecruitment of four additional GBP paralogs (GBP2, GBP3, GBP4, and GBP6).	Arginine	65-73	galectin 1	Homo sapiens	17-20
30263714-0	2017	Effects of l-arginine on growth hormone and insulin-like growth factor 1.	Arginine	11-21	insulin-like growth factor 1	Rattus norvegicus	44-72
30263714-2	2017	In this study, the effects of l-arginine on the expression of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), the two key growth factors, are investigated in cultured GH3 pituitary epithelium and HepG2 cells, respectively.	Arginine	30-40	insulin-like growth factor 1	Rattus norvegicus	86-114
30263714-2	2017	In this study, the effects of l-arginine on the expression of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), the two key growth factors, are investigated in cultured GH3 pituitary epithelium and HepG2 cells, respectively.	Arginine	30-40	insulin-like growth factor 1	Rattus norvegicus	116-121
30263714-3	2017	l-Arginine significantly induced the gene expression of GH and IGF-1 in GH3 pituitary epithelium and HepG2 hepatocytes respectively, and reduced IGF binding protein-1 gene expression in HepG2 cells assessed via quantitative polymerase chain reaction analysis.	Arginine	0-10	insulin like growth factor binding protein 1	Homo sapiens	145-166
28806398-7	2017	We demonstrate that mutation of K52 to arginine (R) renders the MYC protein more labile.	Arginine	39-47	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-67
28542722-5	2017	This variant is predicted to change the highly conserved strongly basic arginine at position 538 in the PAX7 binding domain of PAXBP1 to a neutral cysteine (p.Arg538Cys) residue.	Arginine	72-80	PAX3 and PAX7 binding protein 1	Homo sapiens	127-133
29415833-9	2017	RESULTS: IL-1ra levels exhibited a significant difference both immediately and 1 h after exercise when the l-arg and placebo groups were compared (P &lt; 0.05).	Arginine	107-112	interleukin 1 receptor antagonist	Homo sapiens	9-15
28432085-2	2017	Somatically acquired mutations in DNMT3A occur in haematological malignancies and are frequently present in acute myeloid leukaemia (AML) affecting in more than 50% the arginine residue at position 882 (R882).	Arginine	169-177	DNA methyltransferase 3 alpha	Homo sapiens	34-40
28386107-1	2017	ABL (ABL1) and ARG (ABL2) are highly homologous to each other in overall domain structure and amino-acid sequence, with the exception of their C termini.	Arginine	15-18	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	20-24
28868581-4	2017	Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons.	Arginine	79-89	ornithine transcarbamylase	Homo sapiens	42-45
28868581-4	2017	Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons.	Arginine	79-89	ornithine transcarbamylase	Homo sapiens	137-140
29107098-5	2017	Corticosterone exposure decreased levels of the dendrite stabilization factor Abl2/Arg nonreceptor tyrosine kinase and phosphorylation of its substrates p190RhoGAP and cortactin within 11days, suggesting that disruption of Arg-mediated signaling may trigger dendrite arbor atrophy and, potentially, behavioral abnormalities resulting from corticosterone exposure.	Arginine	83-86	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	78-82
28735657-0	2017	L-arginine Attenuates Hypobaric Hypoxia-Induced Increase in Ornithine Decarboxylase 1.	Arginine	0-10	ornithine decarboxylase 1	Rattus norvegicus	60-85
28735657-9	2017	CONCLUSIONS: L-arginine attenuates acute hypobaric hypoxia-induced increase in mean pulmonary artery pressure and ODC1 gene expression in lung tissues of rats.	Arginine	13-23	ornithine decarboxylase 1	Rattus norvegicus	114-118
29255742-3	2018	Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken up by neighboring cells.	Arginine	61-69	phosphatase and tensin homolog	Homo sapiens	13-17
29255742-3	2018	Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residues that allow PTEN-L to be secreted from cells and be taken up by neighboring cells.	Arginine	61-69	phosphatase and tensin homolog	Homo sapiens	13-17
29045126-6	2017	Phosphorylation of Aurora-A on Thr288 is also necessary for high-affinity binding, and here we identify arginine residues that communicate the phosphorylation of Thr288 to the TPX2 binding site.	Arginine	104-112	TPX2, microtubule-associated L homeolog	Xenopus laevis	176-180
29043790-5	2017	NtzAD+ also serves as a substrate for ribosyl transferases, including human adenosine ribosyl transferase 5 (ART5) and Cholera toxin subunit A (CTA), which hydrolyze the nicotinamide and transfer tzADP-ribose to an arginine analogue, respectively.	Arginine	215-223	ADP-ribosyltransferase 5	Homo sapiens	76-107
29043790-5	2017	NtzAD+ also serves as a substrate for ribosyl transferases, including human adenosine ribosyl transferase 5 (ART5) and Cholera toxin subunit A (CTA), which hydrolyze the nicotinamide and transfer tzADP-ribose to an arginine analogue, respectively.	Arginine	215-223	ADP-ribosyltransferase 5	Homo sapiens	109-113
28817220-7	2017	A key arginine residue in both HAI-1 and HAI-2 is responsible for their interaction with the S1 pocket in KLK14.	Arginine	6-14	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	41-46
28945271-5	2017	We further show that Me31B likely colocalizes with the germ plasm components Tudor (Tud), Vasa, and Aubergine in the nuage and germ plasm and provide evidence that Me31B may directly bind to Tud in a symmetrically dimethylated arginine-dependent manner.	Arginine	227-235	maternal expression at 31B	Drosophila melanogaster	21-26
28945271-5	2017	We further show that Me31B likely colocalizes with the germ plasm components Tudor (Tud), Vasa, and Aubergine in the nuage and germ plasm and provide evidence that Me31B may directly bind to Tud in a symmetrically dimethylated arginine-dependent manner.	Arginine	227-235	maternal expression at 31B	Drosophila melanogaster	164-169
28987235-11	2017	Association of AIT with Arg supplementation was able to improve hemodynamic responses (left ventricular systolic pressure (LVSP), systolic blood pressure (SBP), +dP/dtmax, and -dP/dtmax (p&lt;0.05), likewise, decrease muscular and renal lipid peroxidation and tumor necrosis factor (TNF)-alpha, and increase interleukin (IL)-10/TNF-alpha plasmatic levels (p&lt;0.01).	Arginine	24-27	interleukin 10	Rattus norvegicus	308-327
28855257-7	2017	The ADAMTSL5 autoantigen possessed a P7-Leu instead of the P7-Arg residue, but nevertheless was accommodated within the HLA-C*06:02 antigen-binding cleft.	Arginine	62-65	ADAMTS like 5	Homo sapiens	4-12
29693039-15	2018	Conclusions: We conclude that arginine methylation of STAT1 is suppressed by JMJD6.	Arginine	30-38	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	77-82
28991911-5	2017	In contrast to other IgG subclasses, IgG3 is highly polymorphic and usually contains an arginine at position 435, which reduces its binding affinity to FcRn in vitro.	Arginine	88-96	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	37-41
28865294-5	2017	Molecular modeling studies concluded that recognition with key amino acids Phe 31 and Arg 22 is essential for DHFR binding.	Arginine	86-89	dihydrofolate reductase	Homo sapiens	110-114
27989597-1	2017	Vertebrate ALDH18A1 genes encode a bifunctional mitochondrial enzyme, catalyzing a 2-step conversion of glutamate to glutamyl semialdehyde, subsequently converted into proline, ornithine and arginine.	Arginine	191-199	aldehyde dehydrogenase 18 family, member A1	Rattus norvegicus	11-19
28705740-5	2017	Especially, the glutamine metabolic process related molecules, GPX1, GPX3, SMS, GGCT, GSTK1, NFkappaB, GSTT2, SOD1 and GCLM, are involved in the switching process from oxidized glutathione (GSSG) conversion to the reduced glutathione (GSH) by glutathione, mercapturic acid and arginine metabolism process.	Arginine	277-285	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	103-108
28743672-4	2017	RESULTS: The protein sequence of CYP2U1 displayed two unique characteristics when compared to those of the human CYPs, the presence of a longer N-terminal region upstream of the putative trans-membrane helix (TMH) containing 8 proline residues, and of an insert of about 20 amino acids containing 5 arginine residues between helices A" and A.	Arginine	299-307	cytochrome P450 family 2 subfamily U member 1	Homo sapiens	33-39
28775207-4	2017	Elevated concentrations of G-CSF in PDAC promoted differentiation of Ly6G+ cells from progenitors, stimulated IL10 secretion from myeloid cells, and decreased T-cell proliferation via upregulation of Arg, iNOS, VEGF, IL6, and IL1b from CD11b+ cells.	Arginine	200-203	colony stimulating factor 3	Homo sapiens	27-32
28883820-8	2017	The results demonstrated T. gondii infection to downregulate LILRB4 on decidual macrophages, which strengthened M1 activation functions and weakened M2 tolerance functions by changing M1 and M2 membrane molecule expression, synthesis of arginine metabolic enzymes, and cytokine secretion profiles.	Arginine	237-245	leukocyte immunoglobulin-like receptor, subfamily B, member 4A	Mus musculus	61-67
28652407-0	2017	Arginine methylation regulates c-Myc-dependent transcription by altering promoter recruitment of the acetyltransferase p300.	Arginine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	31-36
28652407-4	2017	Here, we sought to determine whether c-Myc in myeloid cells is regulated by PRMT1-dependent arginine methylation.	Arginine	92-100	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	37-42
28640323-0	2017	Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.	Arginine	17-20	thrombomodulin	Homo sapiens	80-94
28791021-4	2017	Arginine can be recycled in certain mammalian tissues from citrulline via argininosuccinate (ASA) in a two-step enzymatic process involving the enzymes argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL).	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	152-178
28587924-6	2017	ASS1 catalyzes the rate-limiting step of arginine synthesis in urea cycle and citrulline-nitric oxide cycle.	Arginine	41-49	argininosuccinate synthase 1	Homo sapiens	0-4
28592428-7	2017	Although human MOG protein was degraded less in EBV-infected than in uninfected B cells, induction of cathepsin G activity by EBV led to total degradation of the immunodominant peptides MOG35-55 and MOG1-20 Inhibition of cathepsin G or citrullination of the arginine residue within an LC3-interacting region motif of immunodominant MOG peptides abrogated their degradation.	Arginine	258-266	cathepsin G	Homo sapiens	102-113
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Arginine	16-24	Cbl proto-oncogene	Homo sapiens	176-179
28969007-3	2017	Arginine is a semi-essential amino acid that is imported from the extracellular microenvironment or recycled from intracellular precursors through the combined expression of the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) enzymes.	Arginine	0-8	ornithine transcarbamylase	Homo sapiens	214-217
28969007-3	2017	Arginine is a semi-essential amino acid that is imported from the extracellular microenvironment or recycled from intracellular precursors through the combined expression of the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) enzymes.	Arginine	0-8	argininosuccinate synthase 1	Homo sapiens	220-246
28701913-8	2017	Intraportal administration of L-arginine increased the number of Venus positive or c-Fos positive cells in the insular cortex.	Arginine	30-40	FBJ osteosarcoma oncogene	Mus musculus	83-88
28701913-13	2017	Intraportal L-arginine reduced, while intraportal CCK increased, the number of c-Fos positive cells in the nucleus tractus solitarii in a CHBV-dependent manner.	Arginine	12-22	FBJ osteosarcoma oncogene	Mus musculus	79-84
28594296-1	2017	Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult.	Arginine	69-77	transformation related protein 53, pseudogene	Mus musculus	170-173
28594296-1	2017	Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult.	Arginine	69-77	transformation related protein 53, pseudogene	Mus musculus	187-190
28598437-5	2017	Disrupting the "arginine anchor" on CENP-C for the nucleosomal acidic patch disrupts the CENP-A nucleosome structural transition and removes CENP-A nucleosomes from centromeres.	Arginine	16-24	centromere protein C	Homo sapiens	36-42
28392442-0	2017	Protein arginine methylation of Npl3 promotes splicing of the SUS1 intron harboring non-consensus 5" splice site and branch site.	Arginine	8-16	Sus1p	Saccharomyces cerevisiae S288C	62-66
28392442-2	2017	Here we provide evidence that protein arginine methylation of the yeast SR-/hnRNP-like protein Npl3 plays a role in facilitating efficient splicing of the SUS1 intron that harbors a non-consensus 5" splice site and branch site.	Arginine	38-46	Sus1p	Saccharomyces cerevisiae S288C	155-159
28392442-8	2017	Based on these data, we propose a model in which Hmt1, via arginine methylation of Npl3, facilitates U1 snRNP engagement with the pre-mRNA to promote usage of non-consensus splice sites by the splicing machinery.	Arginine	59-67	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	49-53
28388291-1	2017	Purpose Pegylated arginine deiminase (ADI-PEG 20) depletes essential amino acid levels in argininosuccinate synthetase 1 (ASS1) -negative tumors by converting arginine to citrulline and ammonia.	Arginine	18-26	argininosuccinate synthase 1	Homo sapiens	90-120
28388291-1	2017	Purpose Pegylated arginine deiminase (ADI-PEG 20) depletes essential amino acid levels in argininosuccinate synthetase 1 (ASS1) -negative tumors by converting arginine to citrulline and ammonia.	Arginine	18-26	argininosuccinate synthase 1	Homo sapiens	122-126
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	Kar4p	Saccharomyces cerevisiae S288C	148-152
28490494-5	2017	Substitutions of the invariant arginine anchor residue in GAG result in global redistribution of PFV and macaque simian foamy virus (SFVmac) integration sites toward centromeres, dampening the resulting proviral expression without affecting the overall efficiency of integration.	Arginine	31-39	Gag	Macaque simian foamy virus	58-61
28545128-5	2017	The 3q25 signal resides within the arginine/serine-rich coiled-coil 1 (RSRC1) gene and upstream of the myeloid leukemia factor 1 (MLF1) gene.	Arginine	35-43	arginine and serine rich coiled-coil 1	Homo sapiens	71-76
28464862-3	2017	Exome sequencing showed a homozygous mutation in AP4M1, causing the replacement of an arginine by a stop codon at position 338 of the protein (p.Arg338X).	Arginine	86-94	adaptor related protein complex 4 subunit mu 1	Homo sapiens	49-54
28254885-2	2017	In this study, we demonstrate that PDGF-D binds directly to neuropilin 1 (NRP1), in a manner that requires the PDGF-D C-terminal Arg residue.	Arginine	129-132	platelet derived growth factor D	Homo sapiens	35-41
28254885-2	2017	In this study, we demonstrate that PDGF-D binds directly to neuropilin 1 (NRP1), in a manner that requires the PDGF-D C-terminal Arg residue.	Arginine	129-132	platelet derived growth factor D	Homo sapiens	111-117
27899633-2	2017	It has been shown that JMJD6 interacts with and hydroxylates multiple serine/arginine-rich (SR) proteins and SR related proteins, including U2AF65, all of which are known to function in alternative splicing regulation.	Arginine	77-85	jumonji domain containing 6	Mus musculus	23-28
28358054-1	2017	Argininosuccinate synthetase 1 (ASS1) is a rate-limiting enzyme in arginine biosynthesis.	Arginine	67-75	argininosuccinate synthase 1	Homo sapiens	0-30
28358054-1	2017	Argininosuccinate synthetase 1 (ASS1) is a rate-limiting enzyme in arginine biosynthesis.	Arginine	67-75	argininosuccinate synthase 1	Homo sapiens	32-36
28358054-4	2017	ASS1-knockout cells showed enhanced migration and invasion in response to arginine following arginine starvation.	Arginine	74-82	argininosuccinate synthase 1	Homo sapiens	0-4
28358054-4	2017	ASS1-knockout cells showed enhanced migration and invasion in response to arginine following arginine starvation.	Arginine	93-101	argininosuccinate synthase 1	Homo sapiens	0-4
28358054-5	2017	In ASS1-knockout cells, DEPTOR, an inhibitor of mTORC1 signal, was downregulated and mTORC1 signaling was more activated in response to arginine.	Arginine	136-144	argininosuccinate synthase 1	Homo sapiens	3-7
28358054-8	2017	Our findings suggest that ASS1 levels in each tumor cell are associated with invasion capability in response to arginine within the tumor microenvironment through mTORC1 signal regulation.	Arginine	112-120	argininosuccinate synthase 1	Homo sapiens	26-30
28186725-9	2017	Free energy calculations for the wild-type and mutant uPAR bound to uPA or 12 show that Arg-53 interacts with uPA or with 12 in a highly cooperative manner, thereby altering the contributions of hot spots to uPAR binding.	Arginine	88-91	plasminogen activator, urokinase receptor	Homo sapiens	54-58
28186725-9	2017	Free energy calculations for the wild-type and mutant uPAR bound to uPA or 12 show that Arg-53 interacts with uPA or with 12 in a highly cooperative manner, thereby altering the contributions of hot spots to uPAR binding.	Arginine	88-91	plasminogen activator, urokinase receptor	Homo sapiens	208-212
28130275-7	2017	Of particular interest, we found that the aberrant mTOR signaling can be reversed by arginine.	Arginine	85-93	mechanistic target of rapamycin kinase	Mus musculus	51-55
28367100-6	2017	The recruitment of PADI4 and histone H3 arginine modifications to p21 promoter was measured by chromatin immunoprecipitation.	Arginine	40-48	H3 histone pseudogene 16	Homo sapiens	66-69
28367100-9	2017	In RA-FLSs, global H3 citrullination (CitH3) and H3 arginine 17 methylation levels were dynamically changed by PADI4 and ADR treatment.	Arginine	52-60	peptidyl arginine deiminase 4	Homo sapiens	111-116
28367100-12	2017	PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region.	Arginine	63-71	peptidyl arginine deiminase 4	Homo sapiens	0-5
28367100-12	2017	PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region.	Arginine	63-71	H3 histone pseudogene 16	Homo sapiens	17-20
28367100-12	2017	PADI4 suppresses p21 transcription through altering histone H3 arginine modifications on p21 promoter region.	Arginine	63-71	H3 histone pseudogene 16	Homo sapiens	89-92
28003379-7	2017	The Arg/Ser substitution also influenced Ag recognition as determined by CD1d multimer staining and CD1d-restricted functional responses.	Arginine	4-7	CD1d molecule	Homo sapiens	73-77
28003379-7	2017	The Arg/Ser substitution also influenced Ag recognition as determined by CD1d multimer staining and CD1d-restricted functional responses.	Arginine	4-7	CD1d molecule	Homo sapiens	100-104
27838364-4	2017	Hsp47 recognizes collagenous (Gly-Xaa-Arg) repeats on triple-helical procollagen and can prevent local unfolding and/or aggregate formation of procollagen.	Arginine	38-41	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	0-5
28067368-5	2017	We also showed that activation of the Wnt/beta-catenin signal pathway by using lithium chloride (LiCl) significantly attenuated arginine-induced upregulation of PPARgamma and increased the phospho-beta-catenin level.	Arginine	128-136	peroxisome proliferator activated receptor gamma	Sus scrofa	161-170
27865840-6	2017	Furthermore, mutation at Arg-96 abrogated the cofilin-phosphatase activity of SSH1 in the presence of F-actin.	Arginine	25-28	slingshot protein phosphatase 1	Homo sapiens	78-82
28114332-3	2017	This introduces a tryptophan to arginine (W235R) mutation in the catalytic domain of human CPE protein.	Arginine	32-40	carboxypeptidase E	Homo sapiens	91-94
27903651-8	2017	Arginine deprivation-induced cell cycle arrest was mediated in part by Rictor/mTORC2, providing evidence that this nutrient recognition pathway is a central component of how T cells measure environmental arginine.	Arginine	0-8	RPTOR independent companion of MTOR complex 2	Homo sapiens	71-77
27903651-8	2017	Arginine deprivation-induced cell cycle arrest was mediated in part by Rictor/mTORC2, providing evidence that this nutrient recognition pathway is a central component of how T cells measure environmental arginine.	Arginine	204-212	RPTOR independent companion of MTOR complex 2	Homo sapiens	71-77
28849501-6	2017	Taurine and L-arginine promoted apoptosis of VSMCs via increasing the Bax protein expression and decreasing the Bcl-2 protein expression.	Arginine	12-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	70-73
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	64-72	argininosuccinate synthase 1	Homo sapiens	8-38
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	64-72	argininosuccinate synthase 1	Homo sapiens	40-44
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	148-156	argininosuccinate synthase 1	Homo sapiens	8-38
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	148-156	argininosuccinate synthase 1	Homo sapiens	40-44
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	148-156	argininosuccinate synthase 1	Homo sapiens	8-38
27979310-1	2017	Loss of argininosuccinate synthetase 1 (ASS1), a key enzyme for arginine synthesis, occurs in many cancers, making cells dependent on extracellular arginine and targetable by the arginine-degrading enzyme pegylated arginine deiminase (ADI-PEG 20).	Arginine	148-156	argininosuccinate synthase 1	Homo sapiens	40-44
26902604-1	2017	BACKGROUND: Due to the high level of argininosuccinate synthase (ASS), a key enzyme for the formation of arginine from citrulline, human breast cancers are often resistant to arginine deprivation therapy.	Arginine	105-113	argininosuccinate synthase 1	Homo sapiens	37-63
26902604-1	2017	BACKGROUND: Due to the high level of argininosuccinate synthase (ASS), a key enzyme for the formation of arginine from citrulline, human breast cancers are often resistant to arginine deprivation therapy.	Arginine	175-183	argininosuccinate synthase 1	Homo sapiens	37-63
28628911-6	2017	A diagnosis of CARASIL was made with the finding of a novel homozygous missense mutation c.616G&gt;A in HTRA1 gene, resulting in change from Glycine to Arginine in the Serine Protease HTRA1.	Arginine	152-160	HtrA serine peptidase 1	Homo sapiens	104-109
28628911-6	2017	A diagnosis of CARASIL was made with the finding of a novel homozygous missense mutation c.616G&gt;A in HTRA1 gene, resulting in change from Glycine to Arginine in the Serine Protease HTRA1.	Arginine	152-160	HtrA serine peptidase 1	Homo sapiens	184-189
27830885-11	2017	Also, L-arg-induced AP caused a significant elevation of the serum levels of AM, LP, IL-6.	Arginine	6-11	lipase G, endothelial type	Rattus norvegicus	81-83
27406240-1	2017	Arginine 132 (R132) mutations to histidine or cysteine frequently occur to cytosolic NADP+ -isocitrate dehydrogenase (IDH1) in secondary glioblastoma multiforme (GBM) patients, in which GBM develops from a lower grade astroctyoma.	Arginine	0-8	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	118-122
27406240-7	2017	As human IDH1 Arg132 mutation is cancer-associated, the present study provides new information for the in-depth investigation of the metabolic influence of EcIDH Arg mutation in vivo.	Arginine	14-17	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	9-13
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Arginine	248-251	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	76-81
28050723-6	2017	In analogy to CD4, the identified compounds make hydrogen bonds with Asp-368gp120 and multiple van der Waals contacts with the gp120 residues that bind to Phe-43CD4, resulting in destruction of the critical interactions of gp120 with Phe-43CD4 and Arg-59CD4.	Arginine	248-251	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	127-132
29358954-8	2017	Results: Npnt mediates hDPSC adhesion and spreading partially via the Arg-Gly-Asp (RGD) motif.	Arginine	70-73	nephronectin	Homo sapiens	9-13
28078001-8	2016	Following the L-ARG treatment, the expression of the pro-angiogenic factors (VEGF and FGF-2) was higher and the expression of anti-angiogenic factors (endostatin) was lower than the vehicle-treated animals.	Arginine	14-19	vascular endothelial growth factor A	Rattus norvegicus	77-81
27765932-0	2016	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.	Arginine	41-49	argininosuccinate synthase 1	Homo sapiens	103-107
27765932-0	2016	Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1alpha, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.	Arginine	41-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	146-151
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	40-48	argininosuccinate synthase 1	Homo sapiens	122-152
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	40-48	argininosuccinate synthase 1	Homo sapiens	154-158
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	50-53	argininosuccinate synthase 1	Homo sapiens	122-152
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	50-53	argininosuccinate synthase 1	Homo sapiens	154-158
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	117-120	argininosuccinate synthase 1	Homo sapiens	122-152
27765932-1	2016	Many human tumors require extracellular arginine (Arg) for growth because the key enzyme for de novo biosynthesis of Arg, argininosuccinate synthetase 1 (ASS1), is silenced.	Arginine	117-120	argininosuccinate synthase 1	Homo sapiens	154-158
27765932-9	2016	Using two proteasomal inhibitors bortezomib and carfilzomib which induce HIF-1alpha accumulation, we further demonstrated that HIF-1alpha is involved in ASS1 silencing for the maintenance of Arg auxotrophy for targeted Arg-starvation therapy.	Arginine	191-194	argininosuccinate synthase 1	Homo sapiens	153-157
27765932-9	2016	Using two proteasomal inhibitors bortezomib and carfilzomib which induce HIF-1alpha accumulation, we further demonstrated that HIF-1alpha is involved in ASS1 silencing for the maintenance of Arg auxotrophy for targeted Arg-starvation therapy.	Arginine	219-222	argininosuccinate synthase 1	Homo sapiens	153-157
27693049-0	2016	The antiangiogenic and antitumor activities of the N-terminal fragment of endostatin augmented by Ile/Arg substitution: The overall structure implicated the biological activity.	Arginine	102-105	collagen type XVIII alpha 1 chain	Homo sapiens	74-84
27797450-5	2016	SUMMARY: Background Using tissue factor pathway inhibitor (TFPI)-2 Kunitz domain1 (KD1), we obtained a bifunctional antifibrinolytic molecule (KD1L17R -KT ) with C-terminal lysine (kringle domain binding) and P2"-residue arginine (improved specificity towards plasmin).	Arginine	221-229	tissue factor pathway inhibitor 2	Mus musculus	26-66
27681598-9	2016	Furthermore, an l-ANT mutant with the P1 Ile mutated to Arg inhibits thrombin nearly 1500-fold faster than the wild type, which is further accelerated by high molecular weight heparin.	Arginine	56-59	solute carrier family 25 member 6	Homo sapiens	18-21
27840030-0	2016	Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.	Arginine	0-8	malate dehydrogenase 1	Homo sapiens	24-28
27840030-3	2016	Here, we report that methylation on arginine 248 (R248) negatively regulates MDH1.	Arginine	36-44	malate dehydrogenase 1	Homo sapiens	77-81
27840030-8	2016	Our study reveals that arginine methylation of MDH1 by CARM1 regulates cellular redox homeostasis and suppresses glutamine metabolism of pancreatic cancer.	Arginine	23-31	malate dehydrogenase 1	Homo sapiens	47-51
27683223-4	2016	We also show that Chtop interacts with exon 2 of Chtop mRNA via its arginine-glycine-rich (RG) domain, and with intron 2 via its N-terminal (N1) domain; both are required for retention of intron 2.	Arginine	68-76	chromatin target of PRMT1	Homo sapiens	18-23
27683223-4	2016	We also show that Chtop interacts with exon 2 of Chtop mRNA via its arginine-glycine-rich (RG) domain, and with intron 2 via its N-terminal (N1) domain; both are required for retention of intron 2.	Arginine	68-76	chromatin target of PRMT1	Homo sapiens	49-54
27689335-1	2016	The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-responders.	Arginine	34-42	argininosuccinate synthase 1	Homo sapiens	134-138
27689335-1	2016	The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-responders.	Arginine	34-42	argininosuccinate synthase 1	Homo sapiens	164-168
27689335-3	2016	However, the efficacy of the proposed combination in the presence of extracellular citrulline, the substrate for arginine synthesis by ASS1, remains to be elucidated, in particular for malignant cells with positive and/or inducible ASS1 as in colorectal cancer (CRC).	Arginine	113-121	argininosuccinate synthase 1	Homo sapiens	135-139
27560450-5	2016	Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta.	Arginine	36-39	microtubule associated protein tau	Homo sapiens	101-105
26979994-8	2016	The results showed that silymarin and L-Arg macroscopically and microscopically ameliorated TNBS-induced colitis; significantly decreased the serum levels of TNF-alpha; inhibited the colonic expression of iNOS, NF-kappaB, and cytochrome c; and increased expression of HSP70.	Arginine	38-43	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	268-273
27881739-4	2016	In human cells, arginine and tryptophan are co-encoded by the MDH1x UGA stop codon.	Arginine	16-24	malate dehydrogenase 1	Homo sapiens	62-66
27776129-3	2016	Mass spectrometric analysis revealed that several arginine residues within the Scd6 RGG motif, which is important for mRNA binding, were methylated in Hmt1 dependent manner.	Arginine	50-58	Scd6p	Saccharomyces cerevisiae S288C	79-83
27776129-3	2016	Mass spectrometric analysis revealed that several arginine residues within the Scd6 RGG motif, which is important for mRNA binding, were methylated in Hmt1 dependent manner.	Arginine	50-58	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	151-155
27776129-7	2016	Methylation-deficient mutation of Scd6 suppressed the phenotypic defects of scd6 dhh1 double mutant, whereas methylation-mimic mutation did not, suggesting that the arginine methylation might negatively regulate Scd6 function relating to Dhh1.	Arginine	165-173	Scd6p	Saccharomyces cerevisiae S288C	34-38
27776129-7	2016	Methylation-deficient mutation of Scd6 suppressed the phenotypic defects of scd6 dhh1 double mutant, whereas methylation-mimic mutation did not, suggesting that the arginine methylation might negatively regulate Scd6 function relating to Dhh1.	Arginine	165-173	Scd6p	Saccharomyces cerevisiae S288C	76-80
27776129-7	2016	Methylation-deficient mutation of Scd6 suppressed the phenotypic defects of scd6 dhh1 double mutant, whereas methylation-mimic mutation did not, suggesting that the arginine methylation might negatively regulate Scd6 function relating to Dhh1.	Arginine	165-173	Scd6p	Saccharomyces cerevisiae S288C	212-216
27776129-8	2016	Therefore, the present data suggest that Hmt1-based arginine methylation is required for Scd6 localization and function.	Arginine	52-60	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	41-45
27776129-8	2016	Therefore, the present data suggest that Hmt1-based arginine methylation is required for Scd6 localization and function.	Arginine	52-60	Scd6p	Saccharomyces cerevisiae S288C	89-93
27561318-1	2016	Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular endothelial cells through cleavage of the receptor at Arg-46 and Arg-41 protease recognition sites, respectively.	Arginine	228-231	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	64-73
27752365-1	2016	ATE1-mediated post-translational addition of arginine to a protein has been shown to regulate activity, interaction, and stability of the protein substrates.	Arginine	45-53	arginyltransferase 1	Homo sapiens	0-4
26659718-6	2016	RESULTS: Nine arginine residues within FBG were citrullinated by PAD2 and PAD4.	Arginine	14-22	peptidyl arginine deiminase 4	Homo sapiens	74-78
27476855-1	2016	Somatic mutation of the DNMT3A gene at the arginine R882 site is common in acute myeloid leukaemia (AML).	Arginine	43-51	DNA methyltransferase 3 alpha	Homo sapiens	24-30
27510653-3	2016	The results demonstrated that high doses of arginine increased IL-4, IL-10 and TNF-alpha secretion of T cells, while increasing concentrations of lysine increased IL-10 secretion and proliferative activity of the T cells.	Arginine	44-52	interleukin 10	Felis catus	69-74
27510653-3	2016	The results demonstrated that high doses of arginine increased IL-4, IL-10 and TNF-alpha secretion of T cells, while increasing concentrations of lysine increased IL-10 secretion and proliferative activity of the T cells.	Arginine	44-52	tumor necrosis factor	Felis catus	79-88
27556695-1	2016	PADI4 (peptidyl deiminase isoform 4) is overexpressed in many tumor tissues and converts arginine residues to citrulline residues.	Arginine	89-97	peptidyl arginine deiminase 4	Homo sapiens	0-5
27507053-0	2016	The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation.	Arginine	131-139	transformation related protein 53, pseudogene	Mus musculus	127-130
27507053-4	2016	Mechanistic studies reveal that FA deficiency in HSPCs impairs oncogenic stress-induced G1 cell-cycle checkpoint, resulting from a compromised K-rasG12D-induced arginine methylation of p53 mediated by the protein arginine methyltransferase 5 (PRMT5).	Arginine	161-169	transformation related protein 53, pseudogene	Mus musculus	185-188
27507053-6	2016	Our study defines an arginine methylation-dependent FA-p53 interplay that controls oncogenic stress response.	Arginine	21-29	transformation related protein 53, pseudogene	Mus musculus	55-58
27622275-7	2016	Additionally, mechanistic studies revealed that an arginine/lysine-rich element within the DNA-binding domain (SAND domain) is critical for Ipr1 binding to the importin protein receptor NPI-1, demonstrating that this element plays an essential role in mediating the nuclear localization of Ipr1 protein.	Arginine	51-59	karyopherin (importin) alpha 1	Mus musculus	186-191
27586270-0	2016	Novel Fluorescence Arginine Analogue as a Sensor for Direct Identification and Imaging of Nitric Oxide Synthase-like Enzymes in Plants.	Arginine	19-27	putative nitric oxide synthase	Nicotiana tabacum	90-111
27540260-1	2016	SITUATION: Patient I is a 15 year old female with ornithine transcarbamylase deficiency prescribed L-arginine 1.5 g three times daily and sodium benzoate 4.2 g three times daily.	Arginine	99-109	ornithine transcarbamylase	Homo sapiens	50-76
27365393-8	2016	Comparative molecular dynamics indicated that Ser(36) upon phosphorylation will pull the first luminal loop of LTC4S toward the neighboring subunit of the functional homotrimer, thereby forming hydrogen bonds with Arg(104) in the adjacent subunit.	Arginine	214-217	leukotriene C4 synthase	Homo sapiens	111-116
27188911-7	2016	Our simulations, nearing 2 mus in aggregate, indicate that phosphorylation of S2849 induces an "arginine claw" in desmoplakin"s C-terminal tail.	Arginine	96-104	desmoplakin	Homo sapiens	114-125
27247266-6	2016	Mutation of the symmetrically dimethylated arginines within the RGG domain impaired the ability of Lsm4 to promote PB accumulation.	Arginine	43-52	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	99-103
27461362-7	2016	Moreover, cerulein- and arginine-induced serum amylase and lipase were significantly higher in panc-PTP1B KO mice compared with controls.	Arginine	24-32	lipase, endothelial	Mus musculus	59-65
27393304-1	2016	Peptidylarginine deiminase (PAD; EC 3.5.3.15) is a post-translational modification enzyme that catalyzes the conversion of arginine in protein molecules to a citrulline residue in a Ca(2+)-dependent manner.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
27144914-6	2016	The previously reported HOXB1 mutations change arginine 207 to another residue in the homeodomain and alter binding capacity of HOXB1 for transcriptional co-regulators and DNA.	Arginine	47-55	homeobox B1	Homo sapiens	24-29
26518222-1	2016	RF-(Arg-Phe) related peptides (RFRP-1 and -3) are considered to play a role in the seasonal regulation of reproduction; however, the effect of the peptides depends on species and gender.	Arginine	4-7	pro-FMRFamide-related neuropeptide VF	Mesocricetus auratus	31-35
29937815-1	2016	Objective: To investigate the membrane localization function of the CX26 protein when its 86th amino acid is Thr, Ser or Arg, and its relations to deafness.	Arginine	121-124	gap junction protein, beta 2	Mus musculus	68-72
29937815-2	2016	Methods: CX26-GFP protein with either Thr, Ser or Arg as the 86th amino acid was expressed in mouse SGN cells via the GFP fusion type lenti-virus expression system.	Arginine	50-53	gap junction protein, beta 2	Mus musculus	9-13
26876219-9	2016	The deduced amino acid sequence for the protein product revealed an arginine to serine conversion at position 159, which may affect initiation of protein synthesis and disrupt normal TNF-alpha function that protects animals against mycobacterial infection.	Arginine	68-76	tumor necrosis factor	Bos taurus	183-192
26876596-3	2016	Here, we report on the cooperative effect of Tet2 inactivation and DNMT3A mutation affecting arginine 882 (DNMT3A(R882H)) using a murine bone marrow transplantation assay.	Arginine	93-101	tet methylcytosine dioxygenase 2	Mus musculus	45-49
27055482-3	2016	In this work, a short peptide Arg-Glu-Asp-Val (REDV) was linked to trimethyl chitosan (TMC) via a bifunctional poly(ethylene glycol) (PEG) linker for the targeted delivery of microRNA-126 (miRNA-126) to vascular endothelial cells (VECs).	Arginine	30-33	microRNA 126	Homo sapiens	175-187
27055482-3	2016	In this work, a short peptide Arg-Glu-Asp-Val (REDV) was linked to trimethyl chitosan (TMC) via a bifunctional poly(ethylene glycol) (PEG) linker for the targeted delivery of microRNA-126 (miRNA-126) to vascular endothelial cells (VECs).	Arginine	30-33	microRNA 126	Homo sapiens	189-198
27034136-1	2016	In 1994 in the Journal of Cell Science, Hennekes and Nigg reported that changing valine to arginine at the endoproteolytic cleavage site in chicken prelamin A abolishes its conversion to lamin A.	Arginine	91-99	lamin A/C	Gallus gallus	151-158
26581228-4	2016	We report here the first case of a patient with congenital reticular ichthyosiform erythroderma carrying a mutation in KRT10 that does not lead to an arginine-rich reading frame.	Arginine	150-158	keratin 10	Homo sapiens	119-124
27013529-5	2016	One of the variants caused an arginine (R) to cysteine (C) change at codon 35 of the ATPase, Ca(2+) transporting, plasma membrane 3 (Atp2b3) gene encoding PMCA3 that has high expression in the cerebellum.	Arginine	30-38	ATPase plasma membrane Ca2+ transporting 3	Rattus norvegicus	155-160
26819315-8	2016	As an example, methylation of quaking protein in Arg(242) and Arg(256) in SK-Hep1+ cells may play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27(kip1) The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP+- mice.	Arginine	49-52	interferon alpha inducible protein 27	Homo sapiens	203-206
26819315-8	2016	As an example, methylation of quaking protein in Arg(242) and Arg(256) in SK-Hep1+ cells may play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27(kip1) The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP+- mice.	Arginine	62-65	interferon alpha inducible protein 27	Homo sapiens	203-206
27035422-2	2016	Combination of 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomolar domain.	Arginine	40-45	crystallin, gamma B	Mus musculus	21-24
27035422-2	2016	Combination of 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomolar domain.	Arginine	42-45	crystallin, gamma B	Mus musculus	21-24
26912789-5	2016	Together the results demonstrate cross-talk between arginine methylation and serine phosphorylation in ASK1.	Arginine	52-60	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	103-107
26967252-12	2016	Within arginine and proline metabolism, levels of intermediate metabolites in creatine pathway were all significantly lower in IDH mutation positive than in negative patients, suggesting an increased activity of creatine pathway in IDH mutation positive tumors.	Arginine	7-15	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	127-130
26771234-3	2016	Here, we demonstrate that BRAFi-resistant (BR) melanomas are susceptible to arginine deprivation due to inability to initiate re-expression of argininosuccinate synthetase (ASS1, a key enzyme for arginine synthesis) as well as ineffective autophagy.	Arginine	196-204	argininosuccinate synthase 1	Homo sapiens	173-177
26771234-4	2016	Autophagy and ASS1 re-expression are known to protect melanoma cells from cell death upon arginine deprivation.	Arginine	90-98	argininosuccinate synthase 1	Homo sapiens	14-18
26771234-6	2016	Furthermore, our study uncovers that downregulation of deubiquitinase USP28 which results in more active c-Myc degradation via ubiquitin-proteasome machinery is the primary mechanism for inability to re-express ASS1 upon arginine deprivation in BR cells.	Arginine	221-229	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	105-110
26771234-6	2016	Furthermore, our study uncovers that downregulation of deubiquitinase USP28 which results in more active c-Myc degradation via ubiquitin-proteasome machinery is the primary mechanism for inability to re-express ASS1 upon arginine deprivation in BR cells.	Arginine	221-229	argininosuccinate synthase 1	Homo sapiens	211-215
26096933-0	2016	Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.	Arginine	26-34	growth arrest specific 6	Homo sapiens	0-4
26096933-0	2016	Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.	Arginine	26-34	AXL receptor tyrosine kinase	Homo sapiens	5-8
26096933-0	2016	Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.	Arginine	86-94	growth arrest specific 6	Homo sapiens	0-4
26096933-0	2016	Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents.	Arginine	86-94	AXL receptor tyrosine kinase	Homo sapiens	5-8
26096933-1	2016	Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced.	Arginine	53-61	argininosuccinate synthase 1	Homo sapiens	86-116
26096933-1	2016	Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced.	Arginine	53-61	argininosuccinate synthase 1	Homo sapiens	118-122
26096933-1	2016	Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced.	Arginine	63-66	argininosuccinate synthase 1	Homo sapiens	86-116
26096933-1	2016	Many human malignancies lack de novo biosynthesis of arginine (Arg) as the key enzyme argininosuccinate synthetase 1 (ASS1) is silenced.	Arginine	63-66	argininosuccinate synthase 1	Homo sapiens	118-122
26096933-4	2016	Here, we report that an immediate-early event of Arg-auxotrophic response involves reactive oxygen species-mediated secretion of Gas6, which interacts with its receptor Axl and activates the downstream Ras/PI3K/Akt growth signal leading to accumulation of c-Myc by protein stabilization.	Arginine	49-52	growth arrest specific 6	Homo sapiens	129-133
26096933-4	2016	Here, we report that an immediate-early event of Arg-auxotrophic response involves reactive oxygen species-mediated secretion of Gas6, which interacts with its receptor Axl and activates the downstream Ras/PI3K/Akt growth signal leading to accumulation of c-Myc by protein stabilization.	Arginine	49-52	AXL receptor tyrosine kinase	Homo sapiens	169-172
26096933-4	2016	Here, we report that an immediate-early event of Arg-auxotrophic response involves reactive oxygen species-mediated secretion of Gas6, which interacts with its receptor Axl and activates the downstream Ras/PI3K/Akt growth signal leading to accumulation of c-Myc by protein stabilization.	Arginine	49-52	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	256-261
26096933-5	2016	Arg-auxotrophic challenge also transcriptionally upregulates c-Myc expression, which provides a feedback mechanism to enhance Axl expression.	Arginine	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-66
26096933-5	2016	Arg-auxotrophic challenge also transcriptionally upregulates c-Myc expression, which provides a feedback mechanism to enhance Axl expression.	Arginine	0-3	AXL receptor tyrosine kinase	Homo sapiens	126-129
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	59-62	AXL receptor tyrosine kinase	Homo sapiens	99-102
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	59-62	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	59-62	argininosuccinate synthase 1	Homo sapiens	114-118
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	135-138	AXL receptor tyrosine kinase	Homo sapiens	99-102
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	135-138	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
26096933-7	2016	Our results revealed multiple inter-regulatory pathways in Arg-auxotrophic response, consisting of Axl, c-Myc and ASS1, which regulate Arg homeostasis and ADI-PEG20 sensitivity.	Arginine	135-138	argininosuccinate synthase 1	Homo sapiens	114-118
27007815-6	2016	Parenteral arginine significantly increased the B-leukocyte level, decreased the natural killer T (NKT)-leukocyte and splenocyte levels, alleviated the loss in body weight gain and total and cytotoxic T-splenocyte levels, and attenuated the increases in plasma nitrate/nitrite and interferon-gamma production by T-splenocytes.	Arginine	11-19	interferon gamma	Rattus norvegicus	281-297
26972697-4	2016	The latter lack argininosuccinate synthetase (ASS1) making them auxotrophic for arginine.	Arginine	80-88	argininosuccinate synthase 1	Homo sapiens	46-50
26936849-1	2016	Bac7 (1-35) is an Arg- and Pro-rich peptide antibiotic, produced in bovine cells to protect them from microbial infection.	Arginine	18-21	cathelicidin-3	Bos taurus	0-4
26759235-0	2016	Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth.	Arginine	0-8	sterol regulatory element binding transcription factor 1	Homo sapiens	24-31
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Arginine	65-73	HscB mitochondrial iron-sulfur cluster cochaperone	Homo sapiens	227-232
26863604-5	2016	We further found that PI(4)P directly binds Smo through an arginine motif, which then triggers Smo phosphorylation and activation.	Arginine	59-67	smoothened, frizzled class receptor	Mus musculus	44-47
26863604-5	2016	We further found that PI(4)P directly binds Smo through an arginine motif, which then triggers Smo phosphorylation and activation.	Arginine	59-67	smoothened, frizzled class receptor	Mus musculus	95-98
26584823-7	2016	CONCLUSIONS: These results suggested that tektin-t variants (Arg/Cys + Cys/Cys) were probably one of the high risk genetic factors for idiopathic asthenozoospermia among males in Sichuan, China, while the R207H polymorphism may be associated with idiopathic asthenozoospermia risk.	Arginine	61-64	tektin 2	Homo sapiens	42-50
26673819-4	2016	The expression of peptidylarginine deiminase 4 (PADI4), encoding PAD4, a protein that post-translationally converts arginine into citrulline, was restored during ATRA-induced differentiation.	Arginine	26-34	peptidyl arginine deiminase 4	Homo sapiens	48-53
26673819-4	2016	The expression of peptidylarginine deiminase 4 (PADI4), encoding PAD4, a protein that post-translationally converts arginine into citrulline, was restored during ATRA-induced differentiation.	Arginine	26-34	peptidyl arginine deiminase 4	Homo sapiens	65-69
26642391-2	2016	Many tumor cells have suppressed expression of a key enzyme, argininosuccinate synthetase 1 (ASS1), which converts citrulline to arginine.	Arginine	129-137	argininosuccinate synthase 1	Homo sapiens	61-91
26642391-2	2016	Many tumor cells have suppressed expression of a key enzyme, argininosuccinate synthetase 1 (ASS1), which converts citrulline to arginine.	Arginine	129-137	argininosuccinate synthase 1	Homo sapiens	93-97
26853621-9	2016	SRPK2 is a splicing kinase, known to phosphorylate serine/arginine (SR) rich domain proteins and regulate splicing process in eukaryotes.	Arginine	58-66	SRSF protein kinase 2	Homo sapiens	0-5
26583067-4	2015	METHODS: We investigated aggression in mice containing the ASD-associated R451C (arginine to cysteine residue 451 substitution) mutation in neuroligin-3 (NL3).	Arginine	81-89	neuroligin 3	Mus musculus	140-152
26460953-0	2015	PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.	Arginine	47-55	inner centromere protein	Homo sapiens	71-77
26460953-2	2015	We here demonstrate that a protein arginine methyltransferase PRMT1, which are overexpressed in various types of cancer including lung and bladder cancer, methylates arginine 887 in an Aurora Kinase B (AURKB)-binding region of INCENP both in vitro and in vivo.	Arginine	35-43	inner centromere protein	Homo sapiens	227-233
26429332-1	2015	Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as arginine-rich, mutated in early tumors; ARMET), is an ER stress-inducible protein, and widely expressed in mammalian tissues.	Arginine	73-81	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	0-51
26429332-1	2015	Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as arginine-rich, mutated in early tumors; ARMET), is an ER stress-inducible protein, and widely expressed in mammalian tissues.	Arginine	73-81	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	53-57
26429332-1	2015	Mesencephalic astrocyte-derived neurotrophic factor (MANF; also known as arginine-rich, mutated in early tumors; ARMET), is an ER stress-inducible protein, and widely expressed in mammalian tissues.	Arginine	73-81	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	113-118
26383232-5	2015	Melatonin treatment reduced macrophage expression of Cat-2b, Cat1, and ArgI, genes involved in arginine uptake and polyamine synthesis.	Arginine	95-103	GIT ArfGAP 1	Homo sapiens	61-65
26202060-1	2015	BACKGROUND: Carboxypeptidase-D (CPD) cleaves C-terminal arginine for conversion to nitric oxide (NO) by nitric oxide synthase (NOS).	Arginine	56-64	carboxypeptidase D	Homo sapiens	12-30
26202060-1	2015	BACKGROUND: Carboxypeptidase-D (CPD) cleaves C-terminal arginine for conversion to nitric oxide (NO) by nitric oxide synthase (NOS).	Arginine	56-64	carboxypeptidase D	Homo sapiens	32-35
26202060-12	2015	The strong correlation in expression of these proteins in benign and malignant prostate tissues, combined with abundant AR and PRLR, supports in vitro evidence that the CPD-Arg-NO pathway is involved in the regulation of PCa cell proliferation.	Arginine	173-176	carboxypeptidase D	Homo sapiens	169-172
26505901-4	2015	Here we report that the arginine 104 (R104) is critical for the normal function of GPR40.	Arginine	24-32	free fatty acid receptor 1	Homo sapiens	83-88
26299930-4	2015	The REMP DmsD strongly interacts with the twin-arginine motif of the DmsA signal sequence of dimethyl sulfoxide (DMSO) reductase.	Arginine	47-55	solute carrier family 16 member 8	Homo sapiens	4-8
26147657-1	2015	In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (alpha-KG) to R-2-hydroxyglutarate (2-HG).	Arginine	142-150	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	56-60
26147657-1	2015	In recent years, frequent isocitrate dehydrogenase 1/2 (IDH1/IDH2) gene mutations were found in a variety of tumors, which specifically alter arginine residues of catalytic active site in IDH1/IDH2 and confer new enzymatic function of directly catalyzing alpha-ketoglutarate (alpha-KG) to R-2-hydroxyglutarate (2-HG).	Arginine	142-150	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	188-192
26377474-14	2015	Additionally, genetic downregulation of PRMT1 in NAc also attenuated cocaine-caused CPP and locomotion activity, which was associated with decreased expression of histone H4 arginine 3 asymmetric demethylation (H4R3me2a) and hypoacetylation of histone H3 lysine 9 and 14 (acH3K9/K14).	Arginine	174-182	protein arginine N-methyltransferase 1	Mus musculus	40-45
26002808-8	2015	Human ORC1, ORC2, and SLC25A29 are likely to be involved in the biosynthesis and transport of arginine, which can be used as a precursor for the synthesis of NO, agmatine, polyamines, creatine, glutamine, glutamate, and proline, as well as in the degradation of basic amino acids.	Arginine	94-102	solute carrier family 25 member 29	Homo sapiens	22-30
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	247-255	H3 histone pseudogene 16	Homo sapiens	48-51
26405550-6	2015	Conversely, the interaction between the p53 and p21 polymorphisms significantly decreased the risk of prostate cancer, with the odds ratio (OR) being 0.49 [95% confidence interval (CI), 0.27-0.86; P&lt;0.05] for subjects carrying the p53 codon 72 arginine (Arg)/proline (Pro)+Pro/Pro and p21 C98A CA genotypes compared to the combined reference genotypes p53 codon 72 Arg/Arg and p21 C98A CC.	Arginine	257-260	H3 histone pseudogene 16	Homo sapiens	48-51
26010396-3	2015	Recent studies revealed that protein arginine methyltransferase 1 (PRMT1), which accounts for the majority of the type I PRMT activity in cells, methylates two arginine residues in RUNX1 (R206 and R210), and these modifications inhibit corepressor-binding to RUNX1 thereby enhancing its transcriptional activity.	Arginine	37-45	protein arginine N-methyltransferase 1	Mus musculus	67-72
26076332-8	2015	KEY RESULTS: Compound L6H21 inserted into the hydrophobic region of the MD-2 pocket, forming hydrogen bonds with Arg(90) and Tyr(102) in the MD-2 pocket.	Arginine	113-116	lymphocyte antigen 96	Mus musculus	72-76
26076332-8	2015	KEY RESULTS: Compound L6H21 inserted into the hydrophobic region of the MD-2 pocket, forming hydrogen bonds with Arg(90) and Tyr(102) in the MD-2 pocket.	Arginine	113-116	lymphocyte antigen 96	Mus musculus	141-145
26198745-9	2015	Deep parallel sequencing of the dedifferentiated component showed a nonsynonymous mutation at exon 4 of IDH1 gene at codon R132 leading to a substitution of arginine, with serine confirming glandular differentiation in dedifferentiated chondrosarcoma.	Arginine	157-165	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	104-108
26178996-6	2015	We mapped the PRMT6 interaction motif to the pUL69 N terminus and identified critical amino acids within the arginine-rich R1 box of pUL69 that were crucial for PRMT6 and/or UAP56 recruitment.	Arginine	109-117	DExD-box helicase 39B	Homo sapiens	174-179
26178996-8	2015	Thus, we were able to discriminate between arginines within the R1 box of pUL69 that were crucial for UAP56/PRMT6-interaction and/or mRNA export activity.	Arginine	43-52	DExD-box helicase 39B	Homo sapiens	102-107
26178996-13	2015	Furthermore, arginine residues with a crucial function for RNA export and for binding of the cellular RNA export factor UAP56 as well as PRMT6 were mapped within the arginine-rich R1 motif of pUL69.	Arginine	13-21	DExD-box helicase 39B	Homo sapiens	120-125
26178996-13	2015	Furthermore, arginine residues with a crucial function for RNA export and for binding of the cellular RNA export factor UAP56 as well as PRMT6 were mapped within the arginine-rich R1 motif of pUL69.	Arginine	166-174	DExD-box helicase 39B	Homo sapiens	120-125
26134565-4	2015	The ability of RME-8 to associate with PI(3)P and early endosomes is largely abolished when residues Lys(17), Trp(20), Tyr(24), or Arg(26) are mutated resulting in diffuse cytoplasmic localization of RME-8 while maintaining the ability to interact with Hsc70.	Arginine	131-134	DnaJ heat shock protein family (Hsp40) member C13	Homo sapiens	15-20
26425646-0	2015	Gas6/Axl in arginine-starvation therapy.	Arginine	12-20	growth arrest specific 6	Homo sapiens	0-4
26425646-0	2015	Gas6/Axl in arginine-starvation therapy.	Arginine	12-20	AXL receptor tyrosine kinase	Homo sapiens	5-8
26149688-5	2015	Moreover, loading of PAX3 on mitotic chromosomes requires arginine methylation, which is regulated by methyltransferase PRMT5 and demethylase JMJD6.	Arginine	58-66	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	142-147
26267306-3	2015	Herein, we show that Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an arginine methylation-dependent manner.	Arginine	115-123	lysine methyltransferase 2A	Homo sapiens	89-92
26322323-12	2015	We determined that all rHSA samples expressed in rice showed elevated levels of arginine and lysine hexose glycation compared to rHSA expressed in yeast, suggesting that the extensive glycation of the recombinant proteins is a by-product of either the expression system or purification process and not a random occurrence.	Arginine	80-88	CD24 molecule	Rattus norvegicus	23-27
25976429-2	2015	This results in a difference of one amino acid at residue 101 of the HLA-B heavy chain, from a neutral-polar Cys to a basic-polar Arg, thus impairing disulphide bridge formation in the alpha-2 domain.	Arginine	130-133	major histocompatibility complex, class I, B	Homo sapiens	69-74
26041373-3	2015	According to the IMGT unique numbering for G domain, CD1D*03 has one nucleotide transition c136 &gt; t in codon 46, with an arginine-to-cysteine amino acid change (R46 &gt; C) in the D-STRAND, whereas CD1D*04 has one transition c98 &gt; t in codon 33, with a threonine-to-methionine amino acid change (T33 &gt; M) in the C-STRAND.	Arginine	124-132	CD1d molecule	Homo sapiens	53-57
25683148-3	2015	Hepatocytes have galactokinase (GALK), which metabolizes galactose for gluconeogenesis, and ornithine transcarbamylase (OTC), which converts ornithine to arginine in the urea cycle.	Arginine	154-162	ornithine transcarbamylase	Homo sapiens	92-118
25683148-3	2015	Hepatocytes have galactokinase (GALK), which metabolizes galactose for gluconeogenesis, and ornithine transcarbamylase (OTC), which converts ornithine to arginine in the urea cycle.	Arginine	154-162	ornithine transcarbamylase	Homo sapiens	120-123
26022122-8	2015	The structure and structure-based mutational analyses suggest that either the last five residues at the extreme C-terminus of Cdc14p (residues 547-551; Gly-Ser-Ile-Lys-Lys) or adjacent residues with similar sequence (residues 540-544; Gly-Gly-Ile-Arg-Lys) can bind to the NLS-binding site of Kap121p, with two residues (Ile in the middle and Lys at the end of the five residues) of Cdc14p making key contributions to the binding specificity.	Arginine	247-250	phosphoprotein phosphatase CDC14	Saccharomyces cerevisiae S288C	126-132
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Arginine	64-67	5', 3'-nucleotidase, cytosolic	Homo sapiens	108-111
26213944-3	2015	A peptide receptor (His-Pro-Asn-Phe-Ser-Lys-Tyr-Ile-Leu-His-Gln-Arg) that has high binding affinity for 2,4-DNT was immobilized on the surface of the cantilever sensors to detect 2,4-DNT vapor for highly selective detection.	Arginine	64-67	5', 3'-nucleotidase, cytosolic	Homo sapiens	183-186
26186712-1	2015	Augmenting endothelial specific transport of the nitric oxide precursor L-arginine via cationic amino acid transporter-1 (CAT1) can prevent obesity related hypertension.	Arginine	72-82	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	87-120
26186712-1	2015	Augmenting endothelial specific transport of the nitric oxide precursor L-arginine via cationic amino acid transporter-1 (CAT1) can prevent obesity related hypertension.	Arginine	72-82	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	122-126
26034040-13	2015	Jmjd6, a demethylase downregulated with LRP6 deficiency, inhibits OPN and TNAP expression, USF1: histone H3 asymmetrically dimethylated on Arg-17 complex formation, and transactivation.	Arginine	139-142	jumonji domain containing 6	Mus musculus	0-5
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	208-211	H3 histone pseudogene 16	Homo sapiens	4-7
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	289-292	H3 histone pseudogene 16	Homo sapiens	4-7
25232917-9	2015	P53/p21 combination had a better median OS and disease-free survival (DFS) of 12.1 and 13.7 months for wild type cases (GG + Ser/ser) and 20.3 and 20.7 months for patients with either variant genes (GC + Ser/arg) compared with 1.1 and 1.9 months for patients with both variant genes (CC + arg/arg), (P = 0.037 and 0.004).	Arginine	289-292	H3 histone pseudogene 16	Homo sapiens	4-7
26081605-3	2015	The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.	Arginine	30-33	fibronectin 1	Mus musculus	123-134
25940089-6	2015	Of all these residues, tryptophan 79 (arginine 41 in H-RAS), in the interswitch region, modulates the effector selectivity of RAS proteins from H-RAS to E-RAS features.	Arginine	38-46	HRas proto-oncogene, GTPase	Homo sapiens	53-58
25940089-6	2015	Of all these residues, tryptophan 79 (arginine 41 in H-RAS), in the interswitch region, modulates the effector selectivity of RAS proteins from H-RAS to E-RAS features.	Arginine	38-46	HRas proto-oncogene, GTPase	Homo sapiens	144-149
25897024-8	2015	Mutagenesis of the RNA-binding triad of SmD3 (Ser-Asn-Arg) and SmB (His-Asn-Arg) provided insights to built-in redundancies of the Sm ring, whereby no individual side-chain was essential, but simultaneous mutations of Asn or Arg residues in SmD3 and SmB were lethal.	Arginine	54-57	mRNA splicing protein SMD3	Saccharomyces cerevisiae S288C	40-44
25851901-9	2015	We further show that PKCdelta/p38delta signaling suppresses MEP50 expression, leading to reduced H3/H4 arginine dimethylation at the p21(Cip1) promoter, and that this is associated with enhanced p21(Cip1) expression and reduced cell proliferation.	Arginine	103-111	WD repeat domain 77	Homo sapiens	60-65
26178506-8	2015	CONCLUSION: Arg/Gly and Gln/Glu polymorphisms of beta2-AR might have no relationship with the risk of MG associated with thymus abnormality.	Arginine	12-15	adenosine A2a receptor	Homo sapiens	49-57
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	transition protein 2	Homo sapiens	124-127
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	200-204
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	206-210
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	transition protein 2	Homo sapiens	223-226
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	transition protein 2	Homo sapiens	124-127
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	transition protein 2	Homo sapiens	124-127
25955978-8	2015	Hence, interacting acidic and basic residues form favorable AspH(0)-H2O(0)-Arg(+) interactions with hydronium but unfavorable Asp(-)-X(-)/X(+)-Arg(+) interactions with anions/cations.	Arginine	75-78	aspartate beta-hydroxylase	Homo sapiens	60-64
25955978-8	2015	Hence, interacting acidic and basic residues form favorable AspH(0)-H2O(0)-Arg(+) interactions with hydronium but unfavorable Asp(-)-X(-)/X(+)-Arg(+) interactions with anions/cations.	Arginine	143-146	aspartate beta-hydroxylase	Homo sapiens	60-64
25943379-11	2015	The PCR positive samples examined (n = 72) showed a high prevalence of dhfr triple (Asn-108 + Arg-59 + Ile-59) mutant (68%) and dhps double (Gly -437 + Glu-540) mutant (21%).	Arginine	94-97	dihydrofolate reductase	Homo sapiens	71-75
25858298-0	2015	Fortuitous description of haemoglobin A2" [delta16 (A13) Gly Arg (GGC CGC)] in a Tunisian family: study of the molecular defect and its origin.	Arginine	61-64	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	52-55
25858298-3	2015	HbA2" [delta16 (A13) Gly Arg (GGC CGC)] is a delta-chain variant that has been identified in several populations of African origin.	Arginine	25-28	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	16-19
25787993-2	2015	An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma.	Arginine	36-44	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	103-109
25809485-5	2015	We find that the R161Q and R161G CblC mutants display lower protein stability and decreased dealkylation but not decyanation activity, suggesting that cyanocobalamin might be therapeutically useful for patients carrying mutations at Arg-161.	Arginine	233-236	Cbl proto-oncogene C	Homo sapiens	33-37
25884909-6	2015	Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y(+)L-type amino acid transporter-1 (y(+)LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p &lt; 0.05).	Arginine	240-243	solute carrier family 5 member 1	Sus scrofa	33-61
25884909-6	2015	Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y(+)L-type amino acid transporter-1 (y(+)LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p &lt; 0.05).	Arginine	240-243	solute carrier family 5 member 1	Sus scrofa	63-69
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	24-32	WD repeat domain 77	Homo sapiens	49-54
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	24-32	WD repeat domain 77	Homo sapiens	89-94
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	34-37	WD repeat domain 77	Homo sapiens	49-54
25713080-9	2015	Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5.	Arginine	34-37	WD repeat domain 77	Homo sapiens	89-94
25713080-11	2015	We propose a model in which MEP50 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site.	Arginine	112-120	WD repeat domain 77	Homo sapiens	28-33
25710880-3	2015	We show that AML blasts constitutively express the arginine transporters CAT-1 and CAT-2B, and that the majority of newly diagnosed patients" blasts have deficiencies in the arginine-recycling pathway enzymes argininosuccinate synthase and ornithine transcarbamylase, making them arginine auxotrophic.	Arginine	51-59	GIT ArfGAP 1	Homo sapiens	73-78
25710880-3	2015	We show that AML blasts constitutively express the arginine transporters CAT-1 and CAT-2B, and that the majority of newly diagnosed patients" blasts have deficiencies in the arginine-recycling pathway enzymes argininosuccinate synthase and ornithine transcarbamylase, making them arginine auxotrophic.	Arginine	174-182	ornithine transcarbamylase	Homo sapiens	240-266
25753662-6	2015	MBD2IDR also recruits the histone deacetylase core components (RbAp48, HDAC2 and MTA2) of NuRD through a critical contact region requiring two contiguous amino acid residues, Arg(286) and Leu(287).	Arginine	175-178	methyl-CpG binding domain protein 2	Homo sapiens	0-4
25753662-6	2015	MBD2IDR also recruits the histone deacetylase core components (RbAp48, HDAC2 and MTA2) of NuRD through a critical contact region requiring two contiguous amino acid residues, Arg(286) and Leu(287).	Arginine	175-178	RB binding protein 4, chromatin remodeling factor	Homo sapiens	63-69
25867395-6	2015	The meta-analysis results showed that the Arg allele of the beta3-AR gene is positively associated with OAB susceptibility, while Arg allele carriers (Trp64Arg + Arg64Arg) showed positive associations with OAB.	Arginine	42-45	adrenoceptor beta 3	Homo sapiens	60-68
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	140-143	guanylate cyclase activator 1B	Homo sapiens	19-24
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	140-143	guanylate cyclase 2D, retinal	Homo sapiens	169-175
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	149-152	guanylate cyclase activator 1B	Homo sapiens	19-24
25616661-10	2015	Instead, GCAP1 and GCAP2 bind with the cyclase molecule in a mutually exclusive manner using a common or overlapping binding site(s) in the Arg(488)-Arg(851) portion of RetGC1, and mutations in that region causing Leber congenital amaurosis blindness disrupt activation of the cyclase by both GCAP1 and GCAP2.	Arginine	149-152	guanylate cyclase 2D, retinal	Homo sapiens	169-175
25520183-2	2015	Citrullinations are the conversion of arginine to citrulline by peptidylarginine deiminase (PAD) enzymes, which affect protein properties.	Arginine	38-46	peptidyl arginine deiminase 4	Homo sapiens	92-95
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Arginine	74-82	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	37-63
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Arginine	74-82	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	65-69
25853107-2	2015	In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients.	Arginine	74-82	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127
26109968-3	2015	The purpose of this study was to compare the topical versus systemic L-arginine treatment on total nitrite (NOx) and vascular endothelial growth factor (VEGF) concentrations in wound fluid and rate of wound healing in an acute incisional diabetic wound model.	Arginine	69-79	vascular endothelial growth factor A	Rattus norvegicus	117-151
26109968-3	2015	The purpose of this study was to compare the topical versus systemic L-arginine treatment on total nitrite (NOx) and vascular endothelial growth factor (VEGF) concentrations in wound fluid and rate of wound healing in an acute incisional diabetic wound model.	Arginine	69-79	vascular endothelial growth factor A	Rattus norvegicus	153-157
26109968-15	2015	VEGF content in L-arginine treated groups were significantly more than controls (P &lt; 0.05).	Arginine	16-26	vascular endothelial growth factor A	Rattus norvegicus	0-4
25142216-1	2015	Recent comparative genomic studies have identified a chicken gene that codes for a trichohyalin-like protein rich in arginine and glutamic acid termed scaffoldin.	Arginine	117-125	trichohyalin-like	Gallus gallus	151-161
25274782-4	2015	Asymmetric arginine methylation of FUS by the class 1 arginine methyltransferase, protein arginine methyltransferase 1 (PRMT1), regulates nucleocytoplasmic shuttling of FUS.	Arginine	11-19	protein arginine N-methyltransferase 1	Mus musculus	82-118
25274782-4	2015	Asymmetric arginine methylation of FUS by the class 1 arginine methyltransferase, protein arginine methyltransferase 1 (PRMT1), regulates nucleocytoplasmic shuttling of FUS.	Arginine	11-19	protein arginine N-methyltransferase 1	Mus musculus	120-125
25616743-1	2015	BACKGROUND: Argininosuccinate synthetase (ASS) participates in urea and nitric oxide production and is a rate-limiting enzyme in arginine biosynthesis.	Arginine	129-137	argininosuccinate synthetase 1	Mus musculus	12-40
25616743-1	2015	BACKGROUND: Argininosuccinate synthetase (ASS) participates in urea and nitric oxide production and is a rate-limiting enzyme in arginine biosynthesis.	Arginine	129-137	argininosuccinate synthetase 1	Mus musculus	42-45
25429968-5	2015	This PI(4,5)P2 site uses Arg-47 and Lys-13 as phosphate ligands, explaining why PTEN R47G and K13E can no longer be activated by that phosphoinositide.	Arginine	25-28	phosphatase and tensin homolog	Homo sapiens	80-84
25585209-3	2015	We demonstrated that PRMT5-mediated histone arginine methylation is required to elicit ZNF224 transcriptional repression.	Arginine	44-52	zinc finger protein 224	Homo sapiens	87-93
25585209-5	2015	Also, we present evidence that the methylation of KAP1 arginine residues regulate the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification could actively contribute to the regulation of ZNF224-mediated repression.	Arginine	55-63	zinc finger protein 224	Homo sapiens	91-97
25585209-5	2015	Also, we present evidence that the methylation of KAP1 arginine residues regulate the KAP1-ZNF224 interaction, thus suggesting that this KAP1 post-translational modification could actively contribute to the regulation of ZNF224-mediated repression.	Arginine	55-63	zinc finger protein 224	Homo sapiens	221-227
25569348-5	2015	AR transactivation requires PRMT6 catalytic activity and involves methylation of arginine residues at Akt consensus site motifs, which is mutually exclusive with serine phosphorylation by Akt.	Arginine	81-89	Akt1	Drosophila melanogaster	102-105
25461798-3	2015	Here, hydrogen/deuterium exchange mass spectrometry (HDX-MS) was used to study the effects of arginine on recombinant human granulocyte colony-stimulating factor (rhG-CSF) refolding at the scale of peptide mapping.	Arginine	94-102	colony stimulating factor 3	Homo sapiens	124-161
25218309-1	2015	The synthetic 15-mer arginine-glycine-aspartic acid (RGD) domain of osteopontin (OPN) is protective in vitro and in vivo against dopaminergic cell death and this protective effect may be mediated through interaction with integrin receptors to regulate neurotrophic factor levels.	Arginine	21-29	neurotrophin 3	Rattus norvegicus	252-271
26576438-2	2015	Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand beta1 and the beginning of strand beta2, respectively.	Arginine	51-60	hemoglobin, beta adult major chain	Mus musculus	141-146
26285889-1	2015	Arginylation is an enzymatic reaction in which arginyl-tRNA protein transferase 1 (ATE1, EC 2.3.2.8) conjugates a single arginyl moiety from aminoacylated tRNA(Arg) onto a target polypeptide.	Arginine	0-3	arginyltransferase 1	Homo sapiens	47-81
26285889-1	2015	Arginylation is an enzymatic reaction in which arginyl-tRNA protein transferase 1 (ATE1, EC 2.3.2.8) conjugates a single arginyl moiety from aminoacylated tRNA(Arg) onto a target polypeptide.	Arginine	0-3	arginyltransferase 1	Homo sapiens	83-87
25204795-6	2014	RESULTS: We identify two conserved arginine residues (R325 and R335) in Merlin which, in addition to the FERM domain, are required for interaction with Sip1.	Arginine	35-43	Merlin	Drosophila melanogaster	72-78
25204795-6	2014	RESULTS: We identify two conserved arginine residues (R325 and R335) in Merlin which, in addition to the FERM domain, are required for interaction with Sip1.	Arginine	35-43	septin interacting protein 1	Drosophila melanogaster	152-156
25204795-7	2014	Mutation of the arginine residues result in reduced Sip1 binding to Merlin and loss of Merlin growth suppressor function.	Arginine	16-24	septin interacting protein 1	Drosophila melanogaster	52-56
25204795-7	2014	Mutation of the arginine residues result in reduced Sip1 binding to Merlin and loss of Merlin growth suppressor function.	Arginine	16-24	Merlin	Drosophila melanogaster	68-74
25204795-7	2014	Mutation of the arginine residues result in reduced Sip1 binding to Merlin and loss of Merlin growth suppressor function.	Arginine	16-24	Merlin	Drosophila melanogaster	87-93
25130427-2	2014	Here, we demonstrate that deprivation of Slc7a3a leads to hepatic steatosis in fasted zebrafish as a result of defects in arginine-dependent nitric oxide (NO) synthesis.	Arginine	122-130	solute carrier family 7 member 3a	Danio rerio	41-48
25307422-10	2014	Results from LC-MS/MS experiments revealed that MGO covalently adducts the active site Arg 393 of ATIII through two distinct glyoxalation mechanisms.	Arginine	87-90	serpin family C member 1	Homo sapiens	98-103
25181320-10	2014	These results indicate that dietary Arg supplementation attenuates intestinal mucosal disruption in coccidiosis-challenged chickens probably through suppressing TLR4 and activating mTOR complex 1 pathways.	Arginine	36-39	toll like receptor 4	Gallus gallus	161-165
25335675-2	2014	The aim of our study was to investigate whether an L-arginine enteral supplementation (20 g per day) in head and neck cancer patients could modify insulin resistance, leptin and adiponectin levels after surgery.	Arginine	51-61	leptin	Homo sapiens	167-173
25346735-1	2014	BACKGROUND: Erythropoietin (Epo) improves post-traumatic cerebral blood flow (CBF), pressure autoregulation, and vascular reactivity to l-arginine.	Arginine	136-146	erythropoietin	Mus musculus	12-26
25346735-1	2014	BACKGROUND: Erythropoietin (Epo) improves post-traumatic cerebral blood flow (CBF), pressure autoregulation, and vascular reactivity to l-arginine.	Arginine	136-146	erythropoietin	Mus musculus	28-31
25100072-6	2014	We identified l-tryptophan, l-arginine, l-cysteine, and l-lysine as the most potent modulators with effective strength comparable to a supraphysiological dose of amylin.	Arginine	28-38	islet amyloid polypeptide	Rattus norvegicus	162-168
24992318-2	2014	Here, the effect of an equimolar mixture of l-Arg and l-Glu (Arg Glu) on colloidal and conformational stability of four monoclonal antibodies (mAb1-mAb4) at different pH is explored, with the temperatures of the on-set of aggregation (Tagg) and unfolding (Tm1) measured by static light scattering and intrinsic fluorescence, respectively.	Arginine	44-49	immunoglobulin kappa variable 4-62	Mus musculus	148-152
25127856-3	2014	A hallmark is the presence of anti-dsDNA, mutated IgG autoantibodies with a preponderance of arginines in CDR3 of the Ig variable H chain (IgVH).	Arginine	93-102	cerebellar degeneration-related 3	Mus musculus	106-110
25127856-8	2014	The B cells expressed mutated IgVH with multiple arginines in CDR3.	Arginine	49-58	cerebellar degeneration-related 3	Mus musculus	62-66
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	steroid sulfatase	Homo sapiens	174-178
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	183-186	steroid sulfatase	Homo sapiens	174-178
25111608-10	2014	However, we cannot discard that another pathway different from NOS also exists that links L-Arg to AQP2 expression.	Arginine	90-95	aquaporin 2	Rattus norvegicus	99-103
25038828-4	2014	Finally, alterations in serine/arginine-rich splicing factor-6 coincide with tau missplicing, and a role of tau in HD pathogenesis is evidenced by the attenuation of motor abnormalities of mutant HTT transgenic mice in tau knockout backgrounds.	Arginine	31-39	huntingtin	Mus musculus	196-199
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	fatty acid binding protein 4	Homo sapiens	321-349
25054323-5	2014	Furthermore, arginine demonstrated its antiadipogenicity by decreasing adipocyte formation and triglyceride (TG) content in MSCs and inhibiting the mRNA expression of the adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha), and fatty acid binding protein 4 (Fabp4).	Arginine	13-21	fatty acid binding protein 4	Homo sapiens	351-356
25025378-7	2014	RESULTS: Multivariate analysis showed that carriers of the ERCC1 8092 Ala/Ala genotype [hazard ratio (HR) 1.882; 95% confidence interval (CI) 1.031-3.438; P = 0.039] and heavy smokers (&gt;=20 pack-years) carrying the XRCC1 Arg/Arg genotype (HR 2.019; 95% CI 1.010-4.036; P = 0.047) had significantly lower PFS rates.	Arginine	224-227	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	59-64
25025378-7	2014	RESULTS: Multivariate analysis showed that carriers of the ERCC1 8092 Ala/Ala genotype [hazard ratio (HR) 1.882; 95% confidence interval (CI) 1.031-3.438; P = 0.039] and heavy smokers (&gt;=20 pack-years) carrying the XRCC1 Arg/Arg genotype (HR 2.019; 95% CI 1.010-4.036; P = 0.047) had significantly lower PFS rates.	Arginine	228-231	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	59-64
24807184-8	2014	The domestic cat SLAM had threonine at 76, whereas the lion SLAM had arginine, a positively charged residue like that of the dog SLAM.	Arginine	69-77	signaling lymphocytic activation molecule family member 1	Felis catus	60-64
24914048-0	2014	Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins.	Arginine	95-103	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-35
24914048-0	2014	Jumonji domain containing protein 6 (Jmjd6) modulates splicing and specifically interacts with arginine-serine-rich (RS) domains of SR- and SR-like proteins.	Arginine	95-103	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	37-42
24814345-4	2014	In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively.	Arginine	36-44	ribosomal oxygenase 2	Homo sapiens	100-127
24939988-3	2014	Analysis of histone sequences from 160 eukaryotes revealed that the H2A N-terminus has systematically acquired arginines as genomes expanded.	Arginine	111-120	H2A clustered histone 17	Homo sapiens	68-73
24898068-5	2014	The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate.	Arginine	45-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	4-7
24898068-5	2014	The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate.	Arginine	45-53	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	68-72
24898068-5	2014	The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate.	Arginine	77-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	4-7
24898068-5	2014	The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert alpha-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate.	Arginine	77-85	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	4-7
24972470-7	2014	A multiple logistic regression analysis was made in three grouping models: For ADRB3 in the codominant model Trp/Arg genotype, there was an OR of 1.53 (1.09-2.13, P &lt; 0.003) which was increased up to OR 2.99 (1.44-6.22, P &lt; 0.003) for the Arg/Arg genotype.	Arginine	113-116	adrenoceptor beta 3	Homo sapiens	79-84
24972470-7	2014	A multiple logistic regression analysis was made in three grouping models: For ADRB3 in the codominant model Trp/Arg genotype, there was an OR of 1.53 (1.09-2.13, P &lt; 0.003) which was increased up to OR 2.99 (1.44-6.22, P &lt; 0.003) for the Arg/Arg genotype.	Arginine	245-248	adrenoceptor beta 3	Homo sapiens	79-84
24972470-7	2014	A multiple logistic regression analysis was made in three grouping models: For ADRB3 in the codominant model Trp/Arg genotype, there was an OR of 1.53 (1.09-2.13, P &lt; 0.003) which was increased up to OR 2.99 (1.44-6.22, P &lt; 0.003) for the Arg/Arg genotype.	Arginine	245-248	adrenoceptor beta 3	Homo sapiens	79-84
24590270-3	2014	Mutations of IDH1 have been identified at codon 132, with arginine being replaced with histidine in most cases.	Arginine	58-66	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-17
24631830-5	2014	Adopting the reduced chemical diversity design and further restricting the interface diversity to tyrosines, serines, glycines, and arginines only, we have constructed a RNA-targeting Fab library.	Arginine	132-141	FA complementation group B	Homo sapiens	184-187
24631830-7	2014	Using a quantitative specificity assay, we found that these Fabs are highly specific, possibly due to the alternate codon design we used to avoid consecutive arginines in the Fab interface.	Arginine	158-167	FA complementation group B	Homo sapiens	60-63
24652292-4	2014	Its transport properties and kinetic parameters demonstrate that SLC25A29 transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine.	Arginine	85-93	solute carrier family 25 member 29	Homo sapiens	65-73
24615237-0	2014	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.	Arginine	152-160	relaxin 3	Homo sapiens	173-182
24615237-2	2014	Relaxin-3 has three highly conserved arginine residues, B12Arg, B16Arg and B26Arg.	Arginine	37-45	relaxin 3	Homo sapiens	0-9
24615237-8	2014	To identify the ligand residues interacting with the negatively charged EXXXD motif of RXFP3, we replaced the three conserved arginines of relaxin-3 with negatively charged glutamate or aspartate, respectively.	Arginine	126-135	relaxin 3	Homo sapiens	139-148
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Arginine	106-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-59
24626950-4	2014	The present study, showed that forced expression of an IDH1 mutant, of which the 132th amino acid residue arginine is substituted by histidine (IDH1R132H), promoted cell proliferation in cultured cells, while wild-type IDH1 overexpression had no effect on cell proliferation.	Arginine	106-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	144-148
24788778-8	2014	In contrast, except for Arg 0.25X the other experimental groups resulted in lower 4EBP1 expression than the control (P&lt;0.05).	Arginine	24-27	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	82-87
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	casein alpha s1	Bos taurus	32-38
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	Janus kinase 2	Bos taurus	60-64
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	eukaryotic translation initiation factor 4E binding protein 1	Bos taurus	153-158
24797807-8	2014	Tudor is a large protein, which contains multiple Tudor domains--small modules that interact with methylated arginines or lysines of target proteins.	Arginine	109-118	tudor	Drosophila melanogaster	0-5
24797807-8	2014	Tudor is a large protein, which contains multiple Tudor domains--small modules that interact with methylated arginines or lysines of target proteins.	Arginine	109-118	tudor	Drosophila melanogaster	50-55
24384472-8	2014	Through this study, we have provided the first evidence on the pivotal role of arginine 213 that determines the p53 mediated functions of p21 in human cancer cells.	Arginine	79-87	H3 histone pseudogene 16	Homo sapiens	138-141
24517390-6	2014	In human ACAT1, a single-nucleotide polymorphism exists for residue 526: the codon is either CAG for Gln, or CGG for Arg.	Arginine	117-120	acetyl-CoA acetyltransferase 1	Homo sapiens	9-14
24225560-9	2014	However, integrated area under the curve for GH was blunted in the ARG condition (L-arginine = 288.4 +- 368.7 vs. placebo = 487.9+- 482.0 min ng mL1, p &lt; .05).	Arginine	67-70	L1 cell adhesion molecule	Mus musculus	145-148
24600035-5	2014	A highly conserved residue Arg(97) in the CDR3alpha loop played a major role in recognition of peptide and MHC to form a stabilizing ball-and-socket interaction with the MHC and peptide, contributing to the selection of the public TCR clonotype.	Arginine	27-30	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	231-234
23586336-3	2014	As typical in lepidopteran mitogenome E. montanus mitogenome also contained a high A/T content in the whole genome (81.7%) and the CGA (arginine) as the start codon for the COI gene.	Arginine	136-144	COX1	Erynnis montanus	173-176
24529990-2	2014	It is believed that ATE1 links Arg solely to the N terminus of proteins, requiring prior proteolysis or action by Met-aminopeptidases to expose the arginylated site.	Arginine	31-34	arginyltransferase 1	Homo sapiens	20-24
24529990-4	2014	Such arginylation appears to be functionally regulated, and it can be directly mediated by ATE1, in addition to the more conventional ATE1-mediated linkage of Arg to the N-terminal alpha amino group.	Arginine	159-162	arginyltransferase 1	Homo sapiens	134-138
24643009-6	2014	The gating mechanism in the inward-facing state of EAAT3 is found to be different from that of GltPh, which is traced to the relocation of an arginine residue from the HP1 segment in GltPh to the TM8 segment in EAAT3.	Arginine	142-150	defensin alpha 1	Homo sapiens	168-171
24614120-2	2014	Sheep homozygous for alanine at codon 136 and arginine at codons 154 and 171 (ARR/ARR) of the Prnp gene are historically considered to be highly resistant to classical scrapie, although they form a significant fraction of cases of atypical scrapie.	Arginine	46-54	major prion protein	Ovis aries	94-98
24291655-6	2014	The extracellular chromatin incorporates histones in which arginines have been converted to citrullines by peptidylarginine deiminase IV (PAD4).	Arginine	59-68	peptidyl arginine deiminase 4	Homo sapiens	138-142
23459468-7	2014	The KMO Arg(452) allele was associated with psychotic features during manic episodes (P=0.003).	Arginine	8-11	kynurenine 3-monooxygenase	Homo sapiens	4-7
23459468-8	2014	KMO Arg(452) was studied for association to CSF KYNA levels in an independent sample of 55 Swedish patients, and to KMO expression in 717 lymphoblastoid cell lines and 138 hippocampal biopsies.	Arginine	4-7	kynurenine 3-monooxygenase	Homo sapiens	0-3
23459468-9	2014	KMO Arg(452) associated with increased levels of CSF KYNA (P=0.03) and reduced lymphoblastoid and hippocampal KMO expression (P&lt;=0.05).	Arginine	4-7	kynurenine 3-monooxygenase	Homo sapiens	0-3
23459468-9	2014	KMO Arg(452) associated with increased levels of CSF KYNA (P=0.03) and reduced lymphoblastoid and hippocampal KMO expression (P&lt;=0.05).	Arginine	4-7	kynurenine 3-monooxygenase	Homo sapiens	110-113
24433040-1	2014	Plasma membrane-bound carboxypeptidase-D (CPD) cleaves C-terminal arginine from extracellular substrates.	Arginine	66-74	carboxypeptidase D	Homo sapiens	22-40
24570487-4	2014	In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes.	Arginine	62-70	protein arginine N-methyltransferase 6	Mus musculus	10-15
24440480-2	2014	This modification, catalyzed by the protein arginine deiminases (PADs 1-4 and PAD6 in humans), converts the positively charged guanidinium group of an arginine residue into a neutral ureido-group.	Arginine	44-52	peptidyl arginine deiminase 1	Homo sapiens	65-73
24334254-8	2014	This is clearly illustrated by the differences in copy numbers not only in gene PUT1, the main player in the assimilation of proline as a nitrogen source, but also in CAR2, involved in arginine catabolism.	Arginine	185-193	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	167-171
24334254-10	2014	A strain isolated from sugarcane juice fermentations, in which arginine is a rare amino acid, contains less copies of CAR2 and showed low efficiency in arginine assimilation.	Arginine	63-71	ornithine-oxo-acid transaminase	Saccharomyces cerevisiae S288C	118-122
24498420-0	2014	JMJD6 regulates ERalpha methylation on arginine.	Arginine	39-47	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
24327170-6	2014	Compared with day 0, fatty acid synthase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase enzyme activities in s.c. adipose tissue increased by day 14 in steers infused with either alanine or arginine (all P &lt; 0.01).	Arginine	216-224	phosphogluconate dehydrogenase	Bos taurus	81-113
24327170-8	2014	By day 28, C/EBPbeta and SCD gene expression was higher, and CPT1beta gene expression was lower, in s.c. adipose tissue of steers infused with arginine than in steers infused with alanine (+-CLA) (P = 0.05).	Arginine	143-151	CCAAT/enhancer-binding protein beta	Bos taurus	11-20
24327170-8	2014	By day 28, C/EBPbeta and SCD gene expression was higher, and CPT1beta gene expression was lower, in s.c. adipose tissue of steers infused with arginine than in steers infused with alanine (+-CLA) (P = 0.05).	Arginine	143-151	carnitine palmitoyltransferase 1B	Bos taurus	61-69
23707465-1	2014	The single-nucleotide polymorphism rs35761398 in cannabinoid receptor 2 gene (CNR2), which encodes the CB2, substitutes glutamine (Q) 63 with arginine (R), and reduces the function of the gene product.	Arginine	142-150	cannabinoid receptor 2	Homo sapiens	49-71
23707465-1	2014	The single-nucleotide polymorphism rs35761398 in cannabinoid receptor 2 gene (CNR2), which encodes the CB2, substitutes glutamine (Q) 63 with arginine (R), and reduces the function of the gene product.	Arginine	142-150	cannabinoid receptor 2	Homo sapiens	78-82
23707465-1	2014	The single-nucleotide polymorphism rs35761398 in cannabinoid receptor 2 gene (CNR2), which encodes the CB2, substitutes glutamine (Q) 63 with arginine (R), and reduces the function of the gene product.	Arginine	142-150	cannabinoid receptor 2	Homo sapiens	103-106
24368306-5	2014	Pre-test injection of a NO precursor, L-arginine (1 and 2 mug/mouse, intra-CA1) improved memory retention, although the low dose of the drug (0.5 mug/mouse) did not affect memory retention.	Arginine	38-48	carbonic anhydrase 1	Mus musculus	75-78
24368306-7	2014	In other series of experiments, pre-test intra-CA1 injection of L-arginine (0.25 and 0.5 mug/mouse) 5 min before the administration of muscimol (0.1 mug/mouse, intra-CA1) dose dependently inhibited muscimol state-dependent memory.	Arginine	64-74	carbonic anhydrase 1	Mus musculus	47-50
24368306-7	2014	In other series of experiments, pre-test intra-CA1 injection of L-arginine (0.25 and 0.5 mug/mouse) 5 min before the administration of muscimol (0.1 mug/mouse, intra-CA1) dose dependently inhibited muscimol state-dependent memory.	Arginine	64-74	carbonic anhydrase 1	Mus musculus	166-169
23796770-11	2014	IMD treatment increased tissue level of constitutive NO synthase activity and tissue NO content in lungs, and enhanced l-arginine uptake into pulmonary vascular tissues.	Arginine	119-129	adrenomedullin 2	Rattus norvegicus	0-3
23796770-15	2014	Activations l-arginine-NO pathway and of ER stress-specific apoptosis pathway could be the mechanisms mediating the anti-proliferative and pro-apoptotic effects of IMD.	Arginine	12-22	adrenomedullin 2	Rattus norvegicus	164-167
24635366-9	2014	RESULTS: Thirteen potentially functional IL-11 gene variants, the G to A transversions at the position 3651 (G3651A) leading to the arginin to histidin exchange on the position 113 (R113H) were detected in the group of infertile women.	Arginine	132-139	interleukin 11	Homo sapiens	41-46
24452287-3	2014	Here we show that the two shuttling serine/arginine (SR)-proteins Gbp2 and Hrb1 are key surveillance factors for the selective export of spliced mRNAs in yeast.	Arginine	43-51	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	66-70
24225949-0	2013	In planta mutagenesis of Src homology 3 domain-like fold of NdhS, a ferredoxin-binding subunit of the chloroplast NADH dehydrogenase-like complex in Arabidopsis: a conserved Arg-193 plays a critical role in ferredoxin binding.	Arginine	174-177	NAD(P)H-quinone oxidoreductase subunit S	Arabidopsis thaliana	60-64
24225949-10	2013	From these results, we propose that the positive charge of arginine 193 in the SH3-like domain of NdhS is critical for electrostatic interaction with ferredoxin in vivo.	Arginine	59-67	NAD(P)H-quinone oxidoreductase subunit S	Arabidopsis thaliana	98-102
24453997-3	2013	Epigenetic silencing has been identified as a key mechanism for loss of the tumor suppressor role of ASS1 leading to tumoral dependence on exogenous arginine.	Arginine	149-157	argininosuccinate synthase 1	Homo sapiens	101-105
24192130-2	2013	The aim of the present study was to investigate the arginine level in blood, the expression of argininosuccinate synthetase (ASS), the rate-limiting enzyme in arginine synthesis pathway, and the methylation of ASS in patients with PKU.	Arginine	159-167	argininosuccinate synthase 1	Homo sapiens	125-128
24192130-9	2013	CONCLUSIONS: The silencing of ASS due to aberrant promoter CpG methylation may be an important mechanism for arginine biosynthesis disorders in PKU.	Arginine	109-117	argininosuccinate synthase 1	Homo sapiens	30-33
24263033-6	2013	Genetic analysis of this individual showed a heterozygous transversion resulting in amino acid change from arginine to glycine in the PRX gene, suggesting CMT4F.	Arginine	107-115	periaxin	Homo sapiens	134-137
24263033-6	2013	Genetic analysis of this individual showed a heterozygous transversion resulting in amino acid change from arginine to glycine in the PRX gene, suggesting CMT4F.	Arginine	107-115	periaxin	Homo sapiens	155-160
23979920-1	2013	Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis.	Arginine	70-78	argininosuccinate synthase 1	Homo sapiens	108-138
23979920-1	2013	Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis.	Arginine	70-78	argininosuccinate synthase 1	Homo sapiens	140-144
23979920-1	2013	Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis.	Arginine	176-184	argininosuccinate synthase 1	Homo sapiens	108-138
23979920-1	2013	Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis.	Arginine	176-184	argininosuccinate synthase 1	Homo sapiens	140-144
24313001-6	2013	The second SNP of interest, rs1800561 (4693C&gt;T), leads to the substitution of an arginine (R) at codon 140 by tryptophan (W;R140W) in CD38.	Arginine	84-92	CD38 molecule	Homo sapiens	137-141
24043749-6	2013	RESULTS: Patients who received a donor graft containing the functionally stronger KIR2DL1 allele with arginine at amino acid position 245 (KIR2DL1-R(245)) had better survival (P = .0004) and lower cumulative incidence of disease progression (P = .001) than those patients who received a donor graft that contained only the functionally weaker KIR2DL1 allele with cysteine at the same position (KIR2DL1-C(245)).	Arginine	102-110	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	82-89
24043749-6	2013	RESULTS: Patients who received a donor graft containing the functionally stronger KIR2DL1 allele with arginine at amino acid position 245 (KIR2DL1-R(245)) had better survival (P = .0004) and lower cumulative incidence of disease progression (P = .001) than those patients who received a donor graft that contained only the functionally weaker KIR2DL1 allele with cysteine at the same position (KIR2DL1-C(245)).	Arginine	102-110	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	139-146
24043749-6	2013	RESULTS: Patients who received a donor graft containing the functionally stronger KIR2DL1 allele with arginine at amino acid position 245 (KIR2DL1-R(245)) had better survival (P = .0004) and lower cumulative incidence of disease progression (P = .001) than those patients who received a donor graft that contained only the functionally weaker KIR2DL1 allele with cysteine at the same position (KIR2DL1-C(245)).	Arginine	102-110	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	139-146
24043749-6	2013	RESULTS: Patients who received a donor graft containing the functionally stronger KIR2DL1 allele with arginine at amino acid position 245 (KIR2DL1-R(245)) had better survival (P = .0004) and lower cumulative incidence of disease progression (P = .001) than those patients who received a donor graft that contained only the functionally weaker KIR2DL1 allele with cysteine at the same position (KIR2DL1-C(245)).	Arginine	102-110	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1	Homo sapiens	139-146
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 22 member 2	Homo sapiens	163-191
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 22 member 2	Homo sapiens	193-197
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 22 member 2	Homo sapiens	199-206
23864433-5	2013	Compared to vector control cells, uptake of ADMA and L-arginine was significantly higher (p &lt; 0.05) in cells expressing CAT2B and OCT2 at almost all investigated concentrations, while cells expressing CAT2A only showed a significant uptake at concentrations above 300 muM.	Arginine	53-63	solute carrier family 22 member 2	Homo sapiens	133-137
23864433-7	2013	Apparent V max values (nmol mg protein(-1) min(-1)) for cellular uptake of ADMA and L-arginine were  11.8 +- 1.2 and 19.5 +- 0.7 for CAT2A,  14.3 +- 1.0 and 15.3 +- 0.4 for CAT2B, and 6.3 +- 0.3 and &gt;50 for OCT2, respectively.	Arginine	84-94	solute carrier family 22 member 2	Homo sapiens	210-214
23864433-8	2013	Apparent K m values (mumol/l) for cellular uptake of ADMA and L-arginine were  3,033 +- 675 and 3,510 +- 419 for CAT2A,  4,021 +- 532 and 952 +- 92 for CAT2B, and 967 +- 143 and &gt;10,000 for OCT2, respectively.	Arginine	62-72	solute carrier family 22 member 2	Homo sapiens	193-197
23864433-9	2013	ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1.	Arginine	9-19	solute carrier family 22 member 2	Homo sapiens	58-62
23864433-10	2013	Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine.	Arginine	162-172	solute carrier family 22 member 2	Homo sapiens	40-44
23856045-2	2013	Although a variety of human tissues can produce a number of peptidylarginine deiminase (PAD), enzymes that convert peptide bound arginine residues to citrulline, P. gingivalis is one of the few prokaryotes known to express PAD.	Arginine	68-76	peptidyl arginine deiminase 4	Homo sapiens	88-91
23856045-2	2013	Although a variety of human tissues can produce a number of peptidylarginine deiminase (PAD), enzymes that convert peptide bound arginine residues to citrulline, P. gingivalis is one of the few prokaryotes known to express PAD.	Arginine	68-76	peptidyl arginine deiminase 4	Homo sapiens	223-226
23856045-5	2013	Accordingly, the prime purpose of this study was to further characterise PAD in P. gingivalis cells particular emphasis on substrate specificity, using arginine containing peptides and RA relevant proteins.	Arginine	152-160	peptidyl arginine deiminase 4	Homo sapiens	73-76
24025841-6	2013	This inhibition depended on the N-acetylglucosamine transferase activity of NleB1, which specifically modified Arg 117 in the death domain of FADD.	Arginine	111-114	Fas (TNFRSF6)-associated via death domain	Mus musculus	142-146
24049535-2	2013	INTRODUCTION: The aim of the present study was to investigate expression of HSP70 and p-53 proteins as mechanisms of protection of the renal tubular epithelial cells from l-arginine that induces cellular stress.	Arginine	171-181	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	76-81
24049535-2	2013	INTRODUCTION: The aim of the present study was to investigate expression of HSP70 and p-53 proteins as mechanisms of protection of the renal tubular epithelial cells from l-arginine that induces cellular stress.	Arginine	171-181	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	86-90
24049535-10	2013	CONCLUSIONS: The renal epithelial cells responded to L-arginine therapy, increasing expression of HSP70 and p-53 proteins.	Arginine	53-63	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-103
24049535-10	2013	CONCLUSIONS: The renal epithelial cells responded to L-arginine therapy, increasing expression of HSP70 and p-53 proteins.	Arginine	53-63	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	108-112
23991133-5	2013	The arginine-rich carboxy terminus of Spp24 is proteolytically processed to produce three other predictable truncation products (Spp18.1, Spp16.0, and Spp14.5).	Arginine	4-12	secreted phosphoprotein 2	Homo sapiens	38-43
23966993-7	2013	Upon activation, arginase competes with eNOS for the substrate l-arginine, as such impairing eNOS-dependent NO generation and promoting reactive oxygen species generation by the enzyme.	Arginine	63-73	nitric oxide synthase 3, endothelial cell	Mus musculus	40-44
23966993-7	2013	Upon activation, arginase competes with eNOS for the substrate l-arginine, as such impairing eNOS-dependent NO generation and promoting reactive oxygen species generation by the enzyme.	Arginine	63-73	nitric oxide synthase 3, endothelial cell	Mus musculus	93-97
23412876-3	2013	PABPN1 contains 13 dimethylated arginine residues in its C-terminal domain.	Arginine	32-40	poly(A) binding protein nuclear 1	Homo sapiens	0-6
23965885-1	2013	OBJECTIVE: To measure the expression of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) in liver tissue among low-birth-weight newborn rats treated with L-arginine (L-Arg) in early life, and to investigate the effect of L-Arg on insulin resistance.	Arginine	236-241	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	40-69
23935841-8	2013	In addition, L-lactate uptake was measured by hMCT4 arginine mutants.	Arginine	52-60	solute carrier family 16 member 3	Homo sapiens	46-51
23935841-10	2013	RESULTS: In hMCT4-expressing oocytes, treatment with phenylglyoxal (PGO), a compound specific for arginine residues, completely abolished the transport activity of hMCT4, although this abolishment was prevented by the presence of L-lactate.	Arginine	98-106	solute carrier family 16 member 3	Homo sapiens	164-169
23935841-14	2013	CONCLUSIONS: Our results suggest that Arg-278 in TMD8 is a critical residue involved in substrate, L-lactate recognition by hMCT4.	Arginine	38-41	solute carrier family 16 member 3	Homo sapiens	124-129
23632240-6	2013	The miR-34b/c CC-TP53 Arg/Arg combination significantly increased the risk of HCC (AOR: 13.644; 95% CI: 1.451-128.301).	Arginine	22-25	microRNA 34b	Homo sapiens	4-11
23632240-8	2013	CONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T&gt;C, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population.	Arginine	107-110	microRNA 34b	Homo sapiens	89-96
23632240-8	2013	CONCLUSIONS: Our findings suggest that loss of the T allele in miR-34b/c T&gt;C, and the miR-34b/c CC-TP53 Arg/Arg combination increases the risk of HCC in the Korean population.	Arginine	111-114	microRNA 34b	Homo sapiens	89-96
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	258-261	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	159-162
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	258-261	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	159-162
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	262-265	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	159-162
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	262-265	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	159-162
23747011-0	2013	Arginine Methylation Initiates BMP-Induced Smad Signaling.	Arginine	0-8	decapentaplegic	Drosophila melanogaster	31-34
23747011-4	2013	We now show that arginine methylation, which is known to regulate gene expression, yet also modifies some signaling mediators, initiates BMP-induced Smad signaling.	Arginine	17-25	decapentaplegic	Drosophila melanogaster	137-140
23670046-9	2013	The location of these Arg residues in the structure suggests that the Atg13 HORMA domain could act as a phosphorylation-dependent conformational switch.	Arginine	22-25	serine/threonine protein kinase regulatory subunit ATG13	Saccharomyces cerevisiae S288C	70-75
23745682-6	2013	An increased risk associated with the P53 Pro/Pro genotype (OR=2.22, 95% CI=1.30-3.79) compared with the Arg/Arg genotype was also observed.	Arginine	105-108	transformation related protein 53	Mus musculus	38-41
23745682-6	2013	An increased risk associated with the P53 Pro/Pro genotype (OR=2.22, 95% CI=1.30-3.79) compared with the Arg/Arg genotype was also observed.	Arginine	109-112	transformation related protein 53	Mus musculus	38-41
23032405-9	2013	BAT prevalence of older subjects tended to be lower in the UCP1 G/G group than the A allele group (A/A and A/G), and also in the beta3AR Arg allele group (Trp/Arg and Arg/Arg) than the Trp/Trp group.	Arginine	137-140	adrenoceptor beta 3	Homo sapiens	129-136
23032405-12	2013	CONCLUSION: UCP1 -3826 A/G and beta3AR 64 Trp/Arg substitutions accelerate age-related decrease in BAT activity, and thereby may associate with visceral fat accumulation with age.	Arginine	46-49	adrenoceptor beta 3	Homo sapiens	31-38
23549872-3	2013	The roles of ASS1 in tumorigenesis and the therapeutic relevance of the arginine-depriving agent pegylated arginine deiminase (ADI-PEG20) were elucidated in ASS1-deficient myxofibrosarcoma cell lines and xenografts with and without stable ASS1 reexpression.	Arginine	72-80	argininosuccinate synthase 1	Homo sapiens	157-161
23460752-0	2013	Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.	Arginine	0-8	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	105-111
23608644-10	2013	An additional PRR repeat into a proline-arginine-rich motif can dramatically changed the conformation of the intracellular domain of KISS1R and its probable interaction with partner proteins.	Arginine	40-48	KISS1 receptor	Homo sapiens	133-139
23624934-0	2013	Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.	Arginine	0-8	ring finger protein 187	Homo sapiens	46-52
23624934-4	2013	Moreover, RACO-1 is identified as a substrate of the arginine methyltransferase PRMT1, which methylates RACO-1 on two arginine residues.	Arginine	53-61	ring finger protein 187	Homo sapiens	10-16
23624934-4	2013	Moreover, RACO-1 is identified as a substrate of the arginine methyltransferase PRMT1, which methylates RACO-1 on two arginine residues.	Arginine	53-61	ring finger protein 187	Homo sapiens	104-110
23624934-5	2013	Arginine methylation of RACO-1 promotes a conformational change that stabilises RACO-1 by facilitating K63-linked ubiquitin chain formation, and enables RACO-1 dimerisation and c-Jun interaction.	Arginine	0-8	ring finger protein 187	Homo sapiens	24-30
23624934-5	2013	Arginine methylation of RACO-1 promotes a conformational change that stabilises RACO-1 by facilitating K63-linked ubiquitin chain formation, and enables RACO-1 dimerisation and c-Jun interaction.	Arginine	0-8	ring finger protein 187	Homo sapiens	80-86
23624934-5	2013	Arginine methylation of RACO-1 promotes a conformational change that stabilises RACO-1 by facilitating K63-linked ubiquitin chain formation, and enables RACO-1 dimerisation and c-Jun interaction.	Arginine	0-8	ring finger protein 187	Homo sapiens	80-86
23624934-7	2013	These results demonstrate that arginine methylation of RACO-1 is required for efficient transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as an important regulator of c-Jun/AP-1 function.	Arginine	31-39	ring finger protein 187	Homo sapiens	55-61
23640867-5	2013	We report a new, facile, fluorescence-based assay for the detection of PAD4 activity that exploits the substrate specificity of trypsin to monitor the citrullination reaction carried out by PAD4 based on the fact that, upon citrullination, the positively charged arginine side chain is converted to the neutral citrulline.	Arginine	263-271	peptidyl arginine deiminase 4	Homo sapiens	71-75
23640867-5	2013	We report a new, facile, fluorescence-based assay for the detection of PAD4 activity that exploits the substrate specificity of trypsin to monitor the citrullination reaction carried out by PAD4 based on the fact that, upon citrullination, the positively charged arginine side chain is converted to the neutral citrulline.	Arginine	263-271	peptidyl arginine deiminase 4	Homo sapiens	190-194
22777353-0	2013	Histone arginine methylation keeps RUNX1 target genes in an intermediate state.	Arginine	8-16	RUNX family transcription factor 1	Homo sapiens	35-40
23503772-2	2013	Three apoE isoforms (E4, E3, and E2) are the result of cysteine-arginine interchanges at two sites: there are zero interchanges in E4, one interchange in E3, and two interchanges in E2.	Arginine	64-72	ubiquitination factor E4A	Homo sapiens	20-35
23546015-0	2013	Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.	Arginine	95-103	potassium voltage-gated channel subfamily H member 2	Homo sapiens	56-61
23546015-5	2013	This study sought to determine the mechanism(s) by which LQT2 mutations at conserved arginine residues in S4 (R531Q, R531W or R534L) alter Kv11.1 function.	Arginine	85-93	potassium voltage-gated channel subfamily H member 2	Homo sapiens	57-61
23546015-5	2013	This study sought to determine the mechanism(s) by which LQT2 mutations at conserved arginine residues in S4 (R531Q, R531W or R534L) alter Kv11.1 function.	Arginine	85-93	potassium voltage-gated channel subfamily H member 2	Homo sapiens	139-145
23318952-4	2013	The highly conserved p53 Arg(R)-172 is substituted by lysine (K) in Spalax, identical with a tumor-associated mutation.	Arginine	25-28	transformation related protein 53, pseudogene	Mus musculus	21-24
22732180-0	2013	Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients.	Arginine	21-31	serpin family E member 1	Homo sapiens	53-91
22732180-4	2013	The aim of the study was to assess the effect of L-arginine supplementation on PAI 1 concentration and to evaluate the relation to changes in nitric oxide (NO) plasma level, insulin sensitivity (M value), and total antioxidant status (TAS) in obese patients.	Arginine	49-59	serpin family E member 1	Homo sapiens	79-84
22732180-9	2013	RESULTS: We found that 6-month L-arginine supplementation resulted in significant decrease of PAI 1.	Arginine	31-41	serpin family E member 1	Homo sapiens	94-99
22732180-11	2013	In a group of patients treated with L-arginine, negative correlation between a change of insulin sensitivity value and a change of PAI 1 concentration was found.	Arginine	36-46	serpin family E member 1	Homo sapiens	131-136
22732180-12	2013	CONCLUSIONS: The present findings demonstrate favorable influence of L-arginine supplementation on PAI 1 concentration in obese patients.	Arginine	69-79	serpin family E member 1	Homo sapiens	99-104
23362265-6	2013	We found that Arg(27) and Tyr(31) are essential for SLN function.	Arginine	14-17	sarcolipin	Homo sapiens	52-55
23386619-8	2013	Asp-394 on TM8 and Arg-276 on HP1 emerge as key residues that promote the reorientation and diffusion of substrate toward the cell interior.	Arginine	19-22	chromobox 5	Homo sapiens	30-33
23745018-9	2013	The data confirms previous findings on the importance for efficacious binding, of an arginine residue at the 2(nd) position of the gag SL9 epitope, and extends this principle to other epitopes which interacts with HLA B*27.	Arginine	85-93	major histocompatibility complex, class I, B	Homo sapiens	214-219
23341449-6	2013	Specifically, two basic OCAM Ig5 residues (Lys and Arg) found near asparagines equivalent to those carrying the polysialylated N-glycans in NCAM substantially decrease or eliminate polysialylation when used to replace the smaller and more neutral residues (Ser and Asn) in analogous positions in NCAM Ig5.	Arginine	51-54	neural cell adhesion molecule 1	Homo sapiens	140-144
23341449-6	2013	Specifically, two basic OCAM Ig5 residues (Lys and Arg) found near asparagines equivalent to those carrying the polysialylated N-glycans in NCAM substantially decrease or eliminate polysialylation when used to replace the smaller and more neutral residues (Ser and Asn) in analogous positions in NCAM Ig5.	Arginine	51-54	neural cell adhesion molecule 1	Homo sapiens	296-300
23031157-2	2013	Somatic mutations of DNMT3A gene, including recurrent mutations in its Arg-882, were recently reported in acute myelogenous leukemia (AML), strongly suggesting its role in development of AML.	Arginine	71-74	DNA methyltransferase 3 alpha	Homo sapiens	21-27
23031157-4	2013	We identified DNMT3A mutations, especially the Arg-882 mutations, in adulthood AML (9.4%).	Arginine	47-50	DNA methyltransferase 3 alpha	Homo sapiens	14-20
23339388-1	2013	BACKGROUND AND AIM: Arginine is a nonessential amino acid for humans and mice because it can be synthesized from citrulline by argininosuccinate synthetase (ASS) and argininosuccinate lyase.	Arginine	20-28	argininosuccinate synthetase 1	Mus musculus	127-155
23339388-1	2013	BACKGROUND AND AIM: Arginine is a nonessential amino acid for humans and mice because it can be synthesized from citrulline by argininosuccinate synthetase (ASS) and argininosuccinate lyase.	Arginine	20-28	argininosuccinate synthetase 1	Mus musculus	157-160
23984333-8	2013	The presence of the epitope Bw4 determines a conformational change which leads to a stronger interaction between nonpolymorphic arginine at position 79 of HLA-B and KIR3DL1*001 136-142 loop.	Arginine	128-136	major histocompatibility complex, class I, B	Homo sapiens	155-160
23177256-1	2013	A structure-activity relationship (SAR) study of the c-Myc (Myc) inhibitor 10074-G5 (N-([1,1"-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine, 1) - which targets a hydrophobic domain of the Myc oncoprotein that is flanked by arginine residues - was executed in order to determine its pharmacophore.	Arginine	233-241	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	53-58
23924452-2	2013	In the preliminary studies, we developed a mutant endostatin containing Arg-Gly-Asp-Arg-Gly-Asp (RGDRGD) sequences.	Arginine	72-75	collagen type XVIII alpha 1 chain	Homo sapiens	50-60
21737310-2	2013	Seventeen members of the family spanning 3 generations had neurologic syndromes compatible with CADASIL, of whom 5 were genetically confirmed carriers of the Notch3 gene R141C mutation in exon 4 (421(C T) and 141(Cys Arg)).	Arginine	217-220	notch receptor 3	Homo sapiens	158-164
22504132-0	2013	LPS-stimulated RAW264.7 macrophage CAT-2-mediated l-arginine uptake and nitric oxide biosynthesis is inhibited by omega fatty acid lipid emulsion.	Arginine	50-60	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	35-40
22504132-5	2013	In the present study, we hypothesized that omega-3 FA emulsion pretreatment would decrease the production of NO in LPS-stimulated macrophages and that this effect would occur through alterations in the cellular uptake of l-arginine and CAT-2 expression, in addition to iNOS expression.	Arginine	221-231	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	236-241
22889511-6	2013	RESULTS: Arg-treatment increased: 1) basal and insulin-stimulated glycogen synthesis; 2) glucose uptake; 3) palmitate oxidation; 4) p-Akt (Ser(473)), total and plasma membrane GLUT4 content, total and p-AMPK-alpha and p-ACC (Ser(79)), p-GSK-3alpha/beta (Ser(21/9)) and 5) nitrite and c-GMP levels.	Arginine	9-12	solute carrier family 2 member 4	Rattus norvegicus	176-181
23505570-6	2013	We further reveal a role for arginine residues within and near the destruction box sequence in the chromosome association of cyclin B1.	Arginine	29-37	cyclin B1	Homo sapiens	125-134
23308182-7	2013	Akt sites on Clk1 are in the serine/arginine-rich domain and not the kinase domain.	Arginine	36-44	CDC-like kinase 1	Mus musculus	13-17
22928666-8	2012	Interestingly, mice that are deficient in Arg-II gene (Arg-II(-/-) ) are not only protected from age-associated increase in Arg-II, VCAM1/ICAM1, aging markers, and eNOS-uncoupling in the aortas but also reveal a decrease in S6K1 activity.	Arginine	42-45	vascular cell adhesion molecule 1	Mus musculus	132-137
23399839-6	2012	L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK zeta chain and the NK-92 intracellular production of IFN-gamma.	Arginine	0-5	natural cytotoxicity triggering receptor 3	Homo sapiens	80-85
23047948-8	2012	Arginine 51 directly mediates the interaction of Mek1-FHA and phosphorylated Hop1-T318.	Arginine	0-8	Hop1p	Saccharomyces cerevisiae S288C	77-81
23045530-3	2012	Here we show that ATP induces a conformational change within the C-terminal region of Msh6 that protects the trypsin cleavage site after Msh6 residue Arg(1124).	Arginine	150-153	mutS homolog 6	Homo sapiens	86-90
23045530-3	2012	Here we show that ATP induces a conformational change within the C-terminal region of Msh6 that protects the trypsin cleavage site after Msh6 residue Arg(1124).	Arginine	150-153	mutS homolog 6	Homo sapiens	137-141
22871423-1	2012	We developed a paclitaxel-conjugated polymeric micelle, ABP-PEG3.5k-Paclitaxel (APP) consisting of poly (ethylene glycol) (PEG) and arginine-grafted poly (cystaminebisacrylamide-diaminohexane) (ABP) for the co-delivery of gene and drug.	Arginine	132-140	amine oxidase, copper-containing 1	Mus musculus	56-59
22490985-6	2012	Sequence analysis of the coding region of the SCN5A gene, identified a G to A heterozygous missense mutation at nucleotide site 2066 that resulted in a amino-acid substitution of arginine to histidine at amino-acid site 689 (R689H).	Arginine	179-187	sodium voltage-gated channel alpha subunit 5	Homo sapiens	46-51
22872859-0	2012	Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.	Arginine	55-63	chromatin target of PRMT1	Homo sapiens	91-96
22872859-4	2012	5FMC is a nuclear complex that can only be recruited by Chtop when the latter is arginine-methylated by Prmt1.	Arginine	81-89	chromatin target of PRMT1	Homo sapiens	56-61
22952234-5	2012	A highly conserved "double Arg finger" sequence (RPsi(D/E)(D/E)QR) is responsible for LGN GL to bind to GDP bound to Galpha(i).	Arginine	27-30	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	117-123
22902629-12	2012	These results explain an earlier finding that individual arginines and lysines inside human PCNA are essential for polymerase delta processivity (Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.	Arginine	57-66	proliferating cell nuclear antigen	Homo sapiens	92-96
22902629-12	2012	These results explain an earlier finding that individual arginines and lysines inside human PCNA are essential for polymerase delta processivity (Fukuda, K., Morioka, H., Imajou, S., Ikeda, S., Ohtsuka, E., and Tsurimoto, T. (1995) Structure-function relationship of the eukaryotic DNA replication factor, proliferating cell nuclear antigen.	Arginine	57-66	proliferating cell nuclear antigen	Homo sapiens	306-340
23060885-3	2012	We have reported that peptidylarginine deiminase 4 (PAD4), an enzyme that converts Arg or monomethyl-Arg to citrulline in histones, is essential for NET formation.	Arginine	83-86	peptidyl arginine deiminase 4	Homo sapiens	22-50
23060885-3	2012	We have reported that peptidylarginine deiminase 4 (PAD4), an enzyme that converts Arg or monomethyl-Arg to citrulline in histones, is essential for NET formation.	Arginine	83-86	peptidyl arginine deiminase 4	Homo sapiens	52-56
22705350-6	2012	Lysine to arginine mutations within repeats 5-7 identified K394 as the major Rad6B ubiquitination site in vitro and in vivo, and confirmed by Rad6B ubiquitination of a beta-catenin peptide encompassing K394.	Arginine	10-18	catenin beta 1	Homo sapiens	168-180
22532369-3	2012	Previously, it was demonstrated that protein arginine methyltransferase 1 (PRMT1)-dependent arginine modification of FoxO1 interferes with Akt-dependent phosphorylation, both in cancer cells and in the Caenorhabditis elegans model, suggesting that this additional modification of FoxO1 might be critical in its transcriptional activity.	Arginine	45-53	forkhead box O1	Mus musculus	280-285
22532369-4	2012	In this study, we attempted to directly test the effect of arginine methylation of FoxO1 on hepatic glucose metabolism.	Arginine	59-67	forkhead box O1	Mus musculus	83-88
22904064-9	2012	Our findings define a new regulator of p53 transcriptional regulation and define a role for PRMT6 and arginine methylation in cellular senescence.	Arginine	102-110	transformation related protein 53	Mus musculus	39-42
22673595-17	2012	CONCLUSION: These results suggest that in a condition of exogenous AGE administration, supplemental dietary Arg resulted in a more pronounced IL-23/IL-17 immune response, possibly by increasing NO secretion.	Arginine	108-111	interleukin 17A	Rattus norvegicus	148-153
22214652-9	2012	The S.C500 challenge significantly enhanced (P &lt; 0 05) serum C-reactive protein (CRP), interferon-gamma and IL-12 concentrations, but Arg supplementation attenuated (P &lt; 0 05) the increase in CRP level.	Arginine	137-140	C-reactive protein	Sus scrofa	198-201
22863532-5	2012	We defined the C-terminal MLL region as a reader domain for the recognition of arginine methylated proteins such as Pax7.	Arginine	79-87	lysine methyltransferase 2A	Homo sapiens	26-29
22759779-7	2012	CONCLUSIONS: Based on both in-vivo and in-vitro data, we have shown a potential causal association between Arg(972) IRS-1 and elevated plasma ET-1 level in hypertensives, which may account for the aggravated hypertension observed in hypertensives with heterozygous Arg(972) IRS-1.	Arginine	107-110	insulin receptor substrate 1	Homo sapiens	274-279
22759779-7	2012	CONCLUSIONS: Based on both in-vivo and in-vitro data, we have shown a potential causal association between Arg(972) IRS-1 and elevated plasma ET-1 level in hypertensives, which may account for the aggravated hypertension observed in hypertensives with heterozygous Arg(972) IRS-1.	Arginine	265-268	insulin receptor substrate 1	Homo sapiens	116-121
22759779-8	2012	This study for the first time provides insights into the role of Arg(972) IRS-1 in hypertension.	Arginine	65-68	insulin receptor substrate 1	Homo sapiens	74-79
22820534-7	2012	Intra-CA1 injection of the NOS substrate L-arg or the sGC activator YC-1 with an ineffective dose of morphine (0.2mg/kg, i.p.)	Arginine	41-46	carbonic anhydrase 1	Rattus norvegicus	6-9
22820534-9	2012	This response induced by L-arg or YC-1 was reversed by pre-microinjection of Rp-8-Br-PET-cGMPS in the CA1.	Arginine	25-30	carbonic anhydrase 1	Rattus norvegicus	102-105
22730318-2	2012	Argininosuccinate synthase (AS) is a ubiquitous enzyme in mammals and the key enzyme of the NO-citrulline cycle, because it provides the substrate L-arginine for subsequent NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS).	Arginine	147-157	argininosuccinate synthase 1	Homo sapiens	0-26
22730318-2	2012	Argininosuccinate synthase (AS) is a ubiquitous enzyme in mammals and the key enzyme of the NO-citrulline cycle, because it provides the substrate L-arginine for subsequent NO synthesis by inducible, endothelial, and neuronal NO synthase (NOS).	Arginine	147-157	argininosuccinate synthase 1	Homo sapiens	28-30
22847422-5	2012	Here we present crystal structures of Hsp47 in its free form and in complex with homotrimeric synthetic collagen model peptides, each comprising one Hsp47-binding site represented by an arginine at the Yaa-position of a Xaa-Yaa-Gly triplet.	Arginine	186-194	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	38-43
22829666-8	2012	The alkaline sensitivity of hASIC3 is an intrinsic property of the channel, which is supported by the extracellular loop and involves two arginines (R68 and R83) only present in the human clone.	Arginine	138-147	acid sensing ion channel subunit 3	Homo sapiens	28-34
22904127-5	2012	We detected 31 (41.9%) heterozygous IDH1 mutations resulting in arginine-to-histidine substitution (R132H;CGT-CAT).	Arginine	64-72	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-40
22474075-3	2012	Mutation of the solvent-exposed Asp86 and Asp90 of helix-2 to Arg does not affect the enzymatic activity of BPLF1 but abolishes cullin binding and prevents CRL inactivation.	Arginine	62-65	CDK2 associated cullin domain 1	Homo sapiens	128-134
22474075-3	2012	Mutation of the solvent-exposed Asp86 and Asp90 of helix-2 to Arg does not affect the enzymatic activity of BPLF1 but abolishes cullin binding and prevents CRL inactivation.	Arginine	62-65	interleukin 31 receptor A	Homo sapiens	156-159
22653663-3	2012	Previous structural and biochemical work identified a conserved arginine residue (R380 in yeast) in the Hsp90 middle domain (MD) that is required for wild type hydrolysis activity in yeast, and hence proposed to be a catalytic residue.	Arginine	64-72	heat shock protein 90 alpha family class A member 1	Homo sapiens	104-109
22653663-4	2012	As part of our investigations on the origins of species-specific differences in Hsp90 conformational dynamics we probed the role of this MD arginine in bacterial, yeast, and human Hsp90s using a combination of structural and functional approaches.	Arginine	140-148	Hsp90 family chaperone HSP82	Saccharomyces cerevisiae S288C	80-85
22653663-4	2012	As part of our investigations on the origins of species-specific differences in Hsp90 conformational dynamics we probed the role of this MD arginine in bacterial, yeast, and human Hsp90s using a combination of structural and functional approaches.	Arginine	140-148	heat shock protein 90 alpha family class A member 1	Homo sapiens	180-185
22810897-3	2012	Our data demonstrated that Abl and Arg were activated downstream of chemokine receptors and mediated the chemokine-induced tyrosine phosphorylation of human enhancer of filamentation 1 (HEF1), an adaptor protein that is required for the activity of the guanosine triphosphatase Rap1, which mediates cell adhesion and migration.	Arginine	35-38	RAP1A, member of RAS oncogene family	Homo sapiens	278-282
22764101-1	2012	Tumours lacking argininosuccinate synthetase-1 (ASS1) are auxotrophic for arginine and sensitive to amino-acid deprivation.	Arginine	74-82	argininosuccinate synthase 1	Homo sapiens	16-46
22764101-1	2012	Tumours lacking argininosuccinate synthetase-1 (ASS1) are auxotrophic for arginine and sensitive to amino-acid deprivation.	Arginine	74-82	argininosuccinate synthase 1	Homo sapiens	48-52
22773562-3	2012	Chloramines of proline, arginine, and glycine caused significant damage to PCNA in cells.	Arginine	24-32	proliferating cell nuclear antigen	Homo sapiens	75-79
22302399-8	2012	It was found that combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with the two possible genotypes of XPD-Asp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Arginine	37-40	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	133-136
22404651-3	2012	Here, we have demonstrated that a triple Arg (3R) motif in the third intracellular loop functions as a novel ER export signal for alpha(2B)-adrenergic receptor (alpha(2B)-AR).	Arginine	41-44	adrenoceptor alpha 2B	Homo sapiens	130-159
22404651-3	2012	Here, we have demonstrated that a triple Arg (3R) motif in the third intracellular loop functions as a novel ER export signal for alpha(2B)-adrenergic receptor (alpha(2B)-AR).	Arginine	41-44	adrenoceptor alpha 2B	Homo sapiens	161-173
22562154-5	2012	Kap114 containing a lysine-to-arginine point mutation at position 909 mislocalizes to the nucleus and is defective in promoting nuclear import.	Arginine	30-38	Kap114p	Saccharomyces cerevisiae S288C	0-6
22498736-6	2012	PRMT1 not only interacts with but also weakly methylates arginine 142 of AE9a.	Arginine	57-65	protein arginine N-methyltransferase 1	Mus musculus	0-5
22498736-8	2012	We also show that AE9a recruits PRMT1 to promoters of AE9a-activated genes, resulting in enrichment of H4 arginine 3 methylation, H3 Lys9/14 acetylation, and transcription activation.	Arginine	106-114	protein arginine N-methyltransferase 1	Mus musculus	32-37
22357953-0	2012	Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.	Arginine	56-64	G3BP stress granule assembly factor 2	Homo sapiens	80-85
22357953-6	2012	Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive "switch" regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling.	Arginine	0-8	G3BP stress granule assembly factor 2	Homo sapiens	24-29
22357953-6	2012	Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive "switch" regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling.	Arginine	0-8	catenin beta 1	Homo sapiens	121-133
21996744-2	2012	To date, mutations in three active site arginine residues, IDH1 R132, IDH2 R172 and IDH2 R140, have been shown to result in the neomorphic production of 2HG.	Arginine	40-48	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	59-63
22189873-5	2012	An in vitro enzymatic assay monitored by matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry indicates that Jmjd6 is unable to remove the methyl group from histone arginine residues but can hydroxylate the histone H4 tail at lysine residues in a 2-oxoglutarate (2-OG)- and Fe (II)-dependent manner.	Arginine	201-209	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	145-150
22442146-3	2012	IDH1 and IDH2 with cancer-associated mutations at the active site arginines were unable to carry out the reductive carboxylation of alphaKG.	Arginine	66-75	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
22430140-1	2012	Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3).	Arginine	77-87	argininosuccinate synthase 1	Homo sapiens	12-42
22430140-1	2012	Endothelial argininosuccinate synthetase 1 (ASS1) regulates the provision of l-arginine to nitric oxide synthase 3 (NOS3).	Arginine	77-87	argininosuccinate synthase 1	Homo sapiens	44-48
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Arginine	39-47	serpin family E member 1	Homo sapiens	217-222
22181833-4	2012	We found that not only lysine but also arginine and histidine bound well, and when present with an additional proximal positive charge, accounted for about half of the total binding energy of a protein ligand such as PAI-1 (plasminogen activator inhibitor-1).	Arginine	39-47	serpin family E member 1	Homo sapiens	224-257
22322595-2	2012	Here we report that endothelin-converting enzyme-1 (ECE-1) differentially degrades CRF and Ucn1; ECE-1 cleaves Ucn1, but not CRF, at critical residue Arginine-34/35", which is essential for ligand-receptor binding.	Arginine	150-158	endothelin converting enzyme 1	Homo sapiens	20-50
22322595-2	2012	Here we report that endothelin-converting enzyme-1 (ECE-1) differentially degrades CRF and Ucn1; ECE-1 cleaves Ucn1, but not CRF, at critical residue Arginine-34/35", which is essential for ligand-receptor binding.	Arginine	150-158	endothelin converting enzyme 1	Homo sapiens	52-57
22322595-2	2012	Here we report that endothelin-converting enzyme-1 (ECE-1) differentially degrades CRF and Ucn1; ECE-1 cleaves Ucn1, but not CRF, at critical residue Arginine-34/35", which is essential for ligand-receptor binding.	Arginine	150-158	endothelin converting enzyme 1	Homo sapiens	97-102
22431096-4	2012	The cross-referencing of these mutations in candidate genes for muscular dystrophy showed a homozygote mutation c.G674A in exon 4 of LMNA causing a protein change R225Q in an arginine conserved from human to Xenopus tropicalis and in lamin B1.	Arginine	175-183	lamin A/C	Homo sapiens	133-137
22193869-13	2012	In the presence of cirrhosis with superimposed sepsis, simultaneous lowering of ADMA levels and enhancement of L-arginine levels to restore plasma and renal AARs may be an optimal strategy for the treatment of kidney injury.	Arginine	111-121	alanyl-tRNA synthetase 1	Rattus norvegicus	157-161
22311979-7	2012	Importantly, EBS deletion or Arg-337 and Lys-338 mutations abrogated PSGL-1-induced ERK activation, whereas they did not prevent Syk phosphorylation or E-selectin-induced leukocyte slow rolling.	Arginine	29-32	selectin P ligand	Homo sapiens	69-75
22241471-4	2012	We analyzed the in vitro methylation products of a glutathione S-transferase (GST)-PRMT7 fusion protein with robust activity using a variety of arginine-containing synthetic peptides and protein substrates, including a GST fusion with the N-terminal domain of fibrillarin (GST-GAR), myelin basic protein, and recombinant human histones H2A, H2B, H3, and H4.	Arginine	144-152	glutathione S-transferase kappa 1	Homo sapiens	51-76
22241471-4	2012	We analyzed the in vitro methylation products of a glutathione S-transferase (GST)-PRMT7 fusion protein with robust activity using a variety of arginine-containing synthetic peptides and protein substrates, including a GST fusion with the N-terminal domain of fibrillarin (GST-GAR), myelin basic protein, and recombinant human histones H2A, H2B, H3, and H4.	Arginine	144-152	glutathione S-transferase kappa 1	Homo sapiens	78-81
21948185-5	2012	Simultaneous supplementation with L -arginine AND L-NAME resulted in a reversal of changes induced by L-arginine supplementation in the case of AspAT and free radicals in skeletal muscle.	Arginine	34-45	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	144-149
21948185-5	2012	Simultaneous supplementation with L -arginine AND L-NAME resulted in a reversal of changes induced by L-arginine supplementation in the case of AspAT and free radicals in skeletal muscle.	Arginine	102-112	glutamic-oxaloacetic transaminase 1	Rattus norvegicus	144-149
21698367-2	2012	An A to G transition mutation in codon 223, in exon 6 of the leptin receptor gene (LEPR) can result in glutamine to arginine substitution (Gln223Arg).	Arginine	116-124	leptin receptor	Homo sapiens	61-76
21698367-2	2012	An A to G transition mutation in codon 223, in exon 6 of the leptin receptor gene (LEPR) can result in glutamine to arginine substitution (Gln223Arg).	Arginine	116-124	leptin receptor	Homo sapiens	83-87
21688280-1	2012	BACKGROUND: Plasma-membrane carboxypeptidase-D (CPD) releases arginine from extracellular substrates.	Arginine	62-70	carboxypeptidase D	Homo sapiens	28-46
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Arginine	278-281	synaptosome associated protein 25	Homo sapiens	59-65
22170566-3	2012	Using the structure of a complex between the C-terminus of SNAP25 and BoNT/A-LC as a model to design SNAP25-derived pseudosubstrate inhibitors (SNAPIs) that prevent presentation of the scissile bond to the active site, we introduced multiple His residues to replace Ala-Asn-Gln-Arg (residues 195-198) at the substrate cleavage site, with the intent to identify possible side-chain interactions with the active site Zn.	Arginine	278-281	synaptosome associated protein 25	Homo sapiens	101-107
22357865-0	2012	Integrin beta1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.	Arginine	31-34	integrin beta 1 (fibronectin receptor beta)	Mus musculus	0-14
22357865-3	2012	Our biochemical and genetic experiments demonstrate that the intracellular tail of integrin beta1 binds directly to Arg kinase and that this interaction stimulates activity of the Arg substrate p190RhoGAP, an inactivator of the RhoA GTPase.	Arginine	116-119	integrin beta 1 (fibronectin receptor beta)	Mus musculus	83-97
22357865-4	2012	Moreover, genetic manipulations that reduce integrin beta1 signaling through Arg recapitulate the integrin beta1 knock-out phenotype in a gene dose-sensitive manner.	Arginine	77-80	integrin beta 1 (fibronectin receptor beta)	Mus musculus	44-58
22357865-4	2012	Moreover, genetic manipulations that reduce integrin beta1 signaling through Arg recapitulate the integrin beta1 knock-out phenotype in a gene dose-sensitive manner.	Arginine	77-80	integrin beta 1 (fibronectin receptor beta)	Mus musculus	98-112
21826105-2	2012	MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif.	Arginine	21-29	protein arginine N-methyltransferase 1	Mus musculus	44-49
21826105-2	2012	MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif.	Arginine	69-77	protein arginine N-methyltransferase 1	Mus musculus	44-49
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Arginine	158-161	interleukin 24	Homo sapiens	64-69
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Arginine	158-161	interleukin 24	Homo sapiens	92-97
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Arginine	158-161	interleukin 24	Homo sapiens	98-103
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Arginine	158-161	interleukin 24	Homo sapiens	233-238
22248086-3	2012	This rout was exploited to construct a tumor-targeting gene RGD-IL-24 which can express RGD-MDA-7/IL-24 protein that includes the cell adhesive sequence (164)Arg-(165)Gly-(166)Asp (A Glycine residue was inserted into the recombinant MDA-7/IL-24 between Arg164 and Asp165 to form a RGD motif).	Arginine	158-161	interleukin 24	Homo sapiens	98-103
22238332-2	2012	Arginine 132 (R132) mutations in the enzyme IDH1 result in excess production of the metabolite 2-hydroxyglutarate (2HG), which could be used as a biomarker for this subset of gliomas.	Arginine	0-8	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	44-48
23167335-10	2012	Although the MDM2 309G allele was itself without affect, it showed a synergistic effect with P21 ser/arg polymorphism (P value=0.003, OR= 6.807, 95% CI= 1.909-24.629).	Arginine	101-104	H3 histone pseudogene 16	Homo sapiens	93-96
23132568-1	2012	Here, we demonstrated the involvement of the domains in Arabidopsis high-light responsive serine/arginine-rich (SR) and SR-like proteins, atSR30 and atSR45a, respectively, in subcellular and subnuclear distribution using a series of structural domain-deleted mutants.	Arginine	97-105	RNA-binding (RRM/RBD/RNP motifs) family protein	Arabidopsis thaliana	149-156
23481570-5	2012	RESULTS: The allele type Arg/Arg in ECRG1 gene was found in 13 (54.2%) patients, Arg/Gln in 11 (45.8%) patients and Gln/Gln in no patient.	Arginine	25-28	transmembrane serine protease 11A	Homo sapiens	36-41
23481570-5	2012	RESULTS: The allele type Arg/Arg in ECRG1 gene was found in 13 (54.2%) patients, Arg/Gln in 11 (45.8%) patients and Gln/Gln in no patient.	Arginine	29-32	transmembrane serine protease 11A	Homo sapiens	36-41
23481570-5	2012	RESULTS: The allele type Arg/Arg in ECRG1 gene was found in 13 (54.2%) patients, Arg/Gln in 11 (45.8%) patients and Gln/Gln in no patient.	Arginine	29-32	transmembrane serine protease 11A	Homo sapiens	36-41
23086420-2	2012	Mammalian PI phosphatases are conserved through evolution and among this large family the dual-specificity phosphatase (PTP/DSP) are metal-independent enzymes displaying the amino acid signature Cys-X5-Arg-Thr/Ser (CX5RT/S) in their active site.	Arginine	202-205	desmoplakin	Homo sapiens	124-127
22850643-9	2012	Sequencing of the 21 exons of the Kit gene in the Kit(W-Ham) mutants revealed that a unique guanine-to-adenine (G-A) transition at nucleotide position 545 (c.545G&gt;A) of exon 3 changes arginine (R) to glutamine (Q) at position 182 in the extracellular domain of the KIT protein (p.R182Q).	Arginine	187-195	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	34-37
22850643-9	2012	Sequencing of the 21 exons of the Kit gene in the Kit(W-Ham) mutants revealed that a unique guanine-to-adenine (G-A) transition at nucleotide position 545 (c.545G&gt;A) of exon 3 changes arginine (R) to glutamine (Q) at position 182 in the extracellular domain of the KIT protein (p.R182Q).	Arginine	187-195	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	50-53
21965298-9	2012	We propose that arginine methylation by PRMT1 participates in the nuclear-cytoplasmic shuttling of FUS, particularly of ALS6-associated mutants, and thus contributes to the toxic gain of function conferred by these disease-causing mutations.	Arginine	16-24	protein arginine N-methyltransferase 1	Mus musculus	40-45
22553750-4	2012	RESULTS: Mutational analysis of mtDNA in these two Chinese pedigrees revealed one common LHON-associated mutation, G11778A (Arg His), in the MT-ND4 gene.	Arginine	124-127	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	141-147
22848214-0	2012	Inhibitory effects of arginine on the aggregation of bovine insulin.	Arginine	22-30	insulin	Bos taurus	60-67
22848214-1	2012	Static and dynamic light scattering were used to investigate the effects of L-arginine, commonly used to inhibit protein aggregation, on the initial aggregation kinetics of solutions of bovine insulin in 20% acetic acid and 0.1 M NaCl as a model system for amyloidosis.	Arginine	76-86	insulin	Bos taurus	193-200
21660517-6	2012	RESULTS AND CONCLUSION: In our patients, creatine supplementation alone or with its precursors L-glycine and L-arginine showed benefit only in the muscular symptoms of the disease and no improvement in the cognitive and psychiatric manifestations and did not modify brain creatine content on MRS of male and female CTP deficient patients.	Arginine	109-119	solute carrier family 25 member 1	Homo sapiens	315-318
23007062-5	2012	Compared with the control group, plasma adiponectin levels were significantly increased in the POR, POR Arg and POR K groups.	Arginine	104-107	adiponectin, C1Q and collagen domain containing	Mus musculus	40-51
22113295-2	2012	One of the histone modifications, histone citrullination, is catalyzed by an enzyme called peptidylarginine deiminase 4 (PAD4, also called PADI4), which converts both histone arginine (Arg) and mono-methyl arginine residues to citrulline.	Arginine	185-188	peptidyl arginine deiminase 4	Homo sapiens	139-144
22539873-11	2012	CONCLUSIONS: A novel mutation of FBN1 results in an arginine to cysteine residue (p.R974C) substitution, which is responsible for the patients with isolated EL in this Chinese family.	Arginine	52-60	fibrillin 1	Homo sapiens	33-37
23071787-7	2012	The median mRNA levels of p21 and BAX in the tumors of Pro-allele carriers were significantly reduced to 55.7% and 76.9% compared to Arg/Arg patients, whereas p53, MDM2 and PERP expression were hardly altered.	Arginine	137-140	H3 histone pseudogene 16	Homo sapiens	26-29
22479563-1	2012	Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins.	Arginine	55-63	carboxypeptidase M	Homo sapiens	0-18
22479563-1	2012	Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins.	Arginine	55-63	carboxypeptidase M	Homo sapiens	20-23
22319601-5	2012	On these bases the aim of this study is to investigate the mechanism(s) of U-II-induced relaxation in human corpus cavernosum and its relationship with L-arginine/Nitric oxide (NO) pathway.	Arginine	152-162	urotensin 2	Homo sapiens	75-79
22846336-5	2012	Sequence analysis showed that FcTra-2 included a RNA recognition motif and a linker region, which shared high sequence identities with Tra-2 from other species and 2 arginine/serine rich regions.	Arginine	166-174	transformer	Drosophila melanogaster	32-35
22185200-6	2011	The fact that the mutant peptide Vpr75-90 R80A binds more weakly to CypA than the wild-type peptide confirms that Arg-80 is a key residue in the C-terminal binding domain.	Arginine	114-117	peptidylprolyl isomerase A	Homo sapiens	68-72
22186895-3	2011	We reveal that this occurs because of a single amino acid difference at position 435, where IgG3 has an arginine instead of the histidine found in all other IgG subclasses.	Arginine	104-112	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	92-96
21682734-6	2011	The 672C&gt;A missense mutation converted serine into arginine at Position 224 in the Transmembrane Segment 7 of RhAG glycoprotein.	Arginine	54-62	Rh associated glycoprotein	Homo sapiens	113-117
21682734-7	2011	CONCLUSION: These findings provide evidence that the 672C&gt;A missense mutation in the RHAG gene could result in Rh(null)  of the regulator type, and the single-amino-acid change (Ser to Arg) might be critical for assembly of the Rh antigen complex within the membrane.	Arginine	188-191	Rh associated glycoprotein	Homo sapiens	88-92
22004540-3	2011	On the basis of the average percentages of labeling obtained for the lysine and arginine residues by peptide mapping analysis, the positive charges were more distributed on the surface in the Fab region than in the Fc region of rmAb1.	Arginine	80-88	FA complementation group B	Homo sapiens	192-195
21917920-8	2011	Mutations of the first five lysine residues (lysine 10, 11, 12, 19, and 21) to arginine within the HIF1alpha N terminus reduce protein acetylation but render the mutant HIF1alpha protein resistant to HDAC4 and HDACi-mediated inhibition.	Arginine	79-87	histone deacetylase 4	Homo sapiens	200-205
21976137-10	2011	The L5 peptide with 14 amino acids (Arg-Leu-Asn-Val-Gly-Gly-Thr-Tyr-Phe-Leu-Thr-Thr-Arg-Gln) showed selective binding to the GPC-3-expressing tumor cells, as did a shortened L5 peptide (L5-2) with seven amino acids (Tyr-Phe-Leu-Thr-Thr-Arg-Gln).	Arginine	36-39	glypican 3	Homo sapiens	125-130
21976137-10	2011	The L5 peptide with 14 amino acids (Arg-Leu-Asn-Val-Gly-Gly-Thr-Tyr-Phe-Leu-Thr-Thr-Arg-Gln) showed selective binding to the GPC-3-expressing tumor cells, as did a shortened L5 peptide (L5-2) with seven amino acids (Tyr-Phe-Leu-Thr-Thr-Arg-Gln).	Arginine	84-87	glypican 3	Homo sapiens	125-130
21976137-10	2011	The L5 peptide with 14 amino acids (Arg-Leu-Asn-Val-Gly-Gly-Thr-Tyr-Phe-Leu-Thr-Thr-Arg-Gln) showed selective binding to the GPC-3-expressing tumor cells, as did a shortened L5 peptide (L5-2) with seven amino acids (Tyr-Phe-Leu-Thr-Thr-Arg-Gln).	Arginine	84-87	glypican 3	Homo sapiens	125-130
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	37-42
21784066-3	2011	Among such modifications, an important role belongs to protein arginylation - posttranslational tRNA-mediated addition of arginine, to proteins by arginyltransferase, ATE1.	Arginine	122-130	arginyltransferase 1	Homo sapiens	167-171
24834182-3	2011	BACKGROUND: We have investigated whether glutamine to arginine substitution (Gln223Arg) in exon 6 of the leptin receptor gene, has implications for susceptibility to CRC.	Arginine	54-62	leptin receptor	Homo sapiens	105-120
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Arginine	131-134	serpin family C member 1	Homo sapiens	54-59
21875153-5	2011	An analysis of heparin bound conformational states of ATIII using PEARLS software showed that in heparin bound intermediate state, Arg 47 and Arg 13 residues make hydrogen bonds with heparin but in the activated conformation Lys 11 and Lys 114 have more hydrogen bond interactions.	Arginine	142-145	serpin family C member 1	Homo sapiens	54-59
21697349-4	2011	Activation of HPV-16 L1 mRNA splicing by SRp30c required an intact arginine/serine-repeat (RS) domain of SRp30c.	Arginine	67-75	serine and arginine rich splicing factor 9	Homo sapiens	41-47
21647154-3	2011	The identified IDH1 mutations occurred in codon 132 resulting in replacement of arginine with either cysteine (N=3) or histidine (N=1).	Arginine	80-88	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	15-19
21749319-3	2011	We analysed the phosphorylation consensus motif of PKNs using a peptide library approach and demonstrate that both PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3.	Arginine	193-201	protein kinase N3	Homo sapiens	124-128
21863019-2	2011	Recent studies linked the piRNA pathway to TUDOR biology as TUDOR domains of various proteins bind symmetrically methylated Arginine residues in PIWI proteins.	Arginine	124-132	tudor	Drosophila melanogaster	43-48
21863019-2	2011	Recent studies linked the piRNA pathway to TUDOR biology as TUDOR domains of various proteins bind symmetrically methylated Arginine residues in PIWI proteins.	Arginine	124-132	tudor	Drosophila melanogaster	60-65
21601889-8	2011	At high ionic strength (100mM) NfH becomes the main determinant with R(g) of 14.8+-0.2 nm if dephosphorylated and 15+-0.2 nm if phosphorylated.	Arginine	69-70	neurofilament heavy chain	Homo sapiens	31-34
21688838-0	2011	An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding.	Arginine	3-11	Yip1 domain family member 3	Homo sapiens	91-99
21688838-0	2011	An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding.	Arginine	3-11	early growth response 1	Homo sapiens	103-109
21688838-3	2011	However, the third zinc finger domain of native Zif268 contains an Arg residue instead of the conserved Leu.	Arginine	67-70	early growth response 1	Homo sapiens	48-54
21746851-6	2011	We mapped SUMO acceptor sites in alpha-synuclein and showed that simultaneous mutation of lysines 96 and 102 to arginine significantly impaired alpha-synuclein sumoylation in vitro and in cells.	Arginine	112-120	synuclein alpha	Homo sapiens	33-48
21746851-6	2011	We mapped SUMO acceptor sites in alpha-synuclein and showed that simultaneous mutation of lysines 96 and 102 to arginine significantly impaired alpha-synuclein sumoylation in vitro and in cells.	Arginine	112-120	synuclein alpha	Homo sapiens	144-159
21743441-5	2011	Furthermore, we find that Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.	Arginine	194-203	piwi-like RNA-mediated gene silencing 1	Danio rerio	68-72
21540182-5	2011	We also used isolated hepatocytes to examine the action of various oxypurines on ureagenesis and to assess the ameliorating affect of N-carbamylglutamate and/or l-arginine on NAGS inhibition.	Arginine	161-171	N-acetylglutamate synthase	Mus musculus	175-179
21563828-6	2011	The observation of the shedding profiles of ACE2 mutants expressing CHO-K1 and CHO-P cells indicates that the Arg(708)   Glu(708) mutation and the Arg(708)Arg(710)   Glu(708)Glu(710) double mutation produced increases in the amount of ACE2 shed when stimulated by phorbol ester PMA.	Arginine	110-113	angiotensin-converting enzyme 2	Cricetulus griseus	44-48
21606346-6	2011	Importantly, cells transfected with the IL23R glutamine variant show decreased IL-23-mediated signaling compared with the IL23R arginine allele.	Arginine	128-136	interleukin 23 receptor	Homo sapiens	40-45
21498506-2	2011	We show here that Amer1 directly interacts with the armadillo repeats of beta-catenin via a domain consisting of repeated arginine-glutamic acid-alanine (REA) motifs, and that Amer1 assembles the beta-catenin destruction complex at the plasma membrane by recruiting beta-catenin, adenomatous polyposis coli, and Axin/Conductin.	Arginine	122-130	APC membrane recruitment protein 1	Homo sapiens	18-23
21498506-2	2011	We show here that Amer1 directly interacts with the armadillo repeats of beta-catenin via a domain consisting of repeated arginine-glutamic acid-alanine (REA) motifs, and that Amer1 assembles the beta-catenin destruction complex at the plasma membrane by recruiting beta-catenin, adenomatous polyposis coli, and Axin/Conductin.	Arginine	122-130	catenin beta 1	Homo sapiens	73-85
21324097-2	2011	The substitution of arginine (R) for histidine (H) in the 131 position defines three allelic patterns, H/H, R/R, and H/R, resulting in FcgammaRIIA-H/H131 affinity for IgG2 and higher affinity for IgG3 subclasses.	Arginine	20-28	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	196-200
21493957-7	2011	Arginine at the position 709 is a highly evolutionarily conserved residue located in the PigN domain.	Arginine	0-8	phosphatidylinositol glycan anchor biosynthesis class N	Homo sapiens	89-93
21454547-6	2011	Furthermore, substitution of the first arginine led to hyperphosphorylation and accumulation of A-RAF and C-RAF in plasma membrane fraction, indicating that this residue interferes with the recycling process of A-RAF and C-RAF but not B-RAF.	Arginine	39-47	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	96-101
21454547-6	2011	Furthermore, substitution of the first arginine led to hyperphosphorylation and accumulation of A-RAF and C-RAF in plasma membrane fraction, indicating that this residue interferes with the recycling process of A-RAF and C-RAF but not B-RAF.	Arginine	39-47	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	211-216
21454538-0	2011	The catalytic architecture of leukotriene C4 synthase with two arginine residues.	Arginine	63-71	leukotriene C4 synthase	Homo sapiens	30-53
21624287-10	2011	One nonsense mutation in the OTC gene was found at the exon 9 (C. 958 C &gt; T) and his mother was the heterozygote, which caused an arginine to terminate the code at position 320 of the protein (R320X).	Arginine	133-141	ornithine transcarbamylase	Homo sapiens	29-32
21471456-2	2011	The importance of Arg in CDR3 for DNA binding has been shown in mice with transgenes coding for anti-DNA V(H) regions; there is also a close correlation between arginines in CDR3 of antibodies and DNA binding.	Arginine	18-21	cerebellar degeneration-related 3	Mus musculus	174-178
21471456-2	2011	The importance of Arg in CDR3 for DNA binding has been shown in mice with transgenes coding for anti-DNA V(H) regions; there is also a close correlation between arginines in CDR3 of antibodies and DNA binding.	Arginine	161-170	cerebellar degeneration-related 3	Mus musculus	25-29
21471456-2	2011	The importance of Arg in CDR3 for DNA binding has been shown in mice with transgenes coding for anti-DNA V(H) regions; there is also a close correlation between arginines in CDR3 of antibodies and DNA binding.	Arginine	161-170	cerebellar degeneration-related 3	Mus musculus	174-178
21471456-9	2011	These mice show that the endogenous preimmune repertoire does indeed include a high frequency of antibodies with Arg in their CDR3s (putative anti-DNAs) and they are associated mainly with the editor L chain lambdax.	Arginine	113-116	cerebellar degeneration-related 3	Mus musculus	126-130
21277313-1	2011	Prevention of cation permeation in wild-type aquaporin-1 (AQP1) is believed to be associated with the Asn-Pro-Ala (NPA) region and the aromatic/arginine selectivity filter (SF) domain.	Arginine	144-152	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	45-56
21277313-1	2011	Prevention of cation permeation in wild-type aquaporin-1 (AQP1) is believed to be associated with the Asn-Pro-Ala (NPA) region and the aromatic/arginine selectivity filter (SF) domain.	Arginine	144-152	aquaporin 1 (Colton blood group) L homeolog	Xenopus laevis	58-62
21183608-6	2011	RESULTS: Children with the EPHX1 Arg/His or Arg/Arg genotypes at codon 139 were significantly associated with increased risks of lifetime asthma (adjusted OR [aOR] = 1.3; 95% CI, 1.1-1.7; and aOR = 1.5; 95% CI, 1.1-2.1, respectively).	Arginine	33-36	epoxide hydrolase 1	Homo sapiens	27-32
21282198-4	2011	We observed that Sal B and Tan IIA have cardioprotective effects in an in vivo myocardial infarction model of C57 mice, have vasodilator action in a ex vivo micro-artery system through the endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway and are involved in the regulation of the L-arginine/eNOS/NO pathways in human umbilical vein endothelial cells (HUVECs).	Arginine	298-308	nitric oxide synthase 3, endothelial cell	Mus musculus	189-222
21352804-1	2011	Isocitrate dehydrogenase 1 (IDH1) mutations, which are early and frequent genetic alterations in gliomas, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1.	Arginine	181-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
21352804-1	2011	Isocitrate dehydrogenase 1 (IDH1) mutations, which are early and frequent genetic alterations in gliomas, are specific to a single codon in the conserved and functionally important Arginine 132 (R132) in IDH1.	Arginine	181-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	204-208
21219670-7	2011	Arginine supplementation increased (P&lt;0 05) protein levels for vascular endothelial growth factor(VEGF) in duodenal, jejunal and ileal mucosae by 14, 39 and 35 %, respectively.	Arginine	0-8	vascular endothelial growth factor A	Sus scrofa	101-105
21219670-9	2011	These results indicate that arginine supplementation enhances intestinal growth, development and expression of VEGF in early-weaned pigs fed a maize- and soyabean meal-based diet.	Arginine	28-36	vascular endothelial growth factor A	Sus scrofa	111-115
21144910-5	2011	Variants of the third domain (D3) of receptor-associated protein (RAP) were created carrying lysine to alanine or arginine replacements at the putative contact residues K253, K256 and K270.	Arginine	114-122	LDL receptor related protein associated protein 1	Homo sapiens	37-64
21144910-5	2011	Variants of the third domain (D3) of receptor-associated protein (RAP) were created carrying lysine to alanine or arginine replacements at the putative contact residues K253, K256 and K270.	Arginine	114-122	LDL receptor related protein associated protein 1	Homo sapiens	66-69
21245379-1	2011	A common polymorphism at codon 72 in the p53 tumor suppressor gene encodes either proline (P72) or arginine (R72).	Arginine	99-107	transformation related protein 53, pseudogene	Mus musculus	41-44
21282473-4	2011	Although these changes typically have negative effects on protein function, recent studies suggested that isoAsp formation at certain Asn-Gly-Arg (NGR) sites in ECM proteins have a gain-of-function effect, because the resulting isoAsp-Gly-Arg (isoDGR) sequence can mimic Arg-Gly-Asp (RGD), a well-known integrin-binding motif.	Arginine	142-145	multimerin 1	Homo sapiens	161-164
21245532-3	2011	PAD4 promotes the deimination of arginine residues in histones and may regulate transcription in the context of the chromatin.	Arginine	33-41	peptidyl arginine deiminase 4	Homo sapiens	0-4
20567862-0	2011	Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase.	Arginine	33-41	D-aspartate oxidase	Homo sapiens	105-124
20567862-0	2011	Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase.	Arginine	50-58	D-aspartate oxidase	Homo sapiens	105-124
20625780-0	2011	Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p.	Arginine	123-131	transcription factor MCM1	Saccharomyces cerevisiae S288C	0-5
20625780-0	2011	Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p.	Arginine	123-131	argininosuccinate synthase	Saccharomyces cerevisiae S288C	27-31
20625780-1	2011	In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation.	Arginine	75-83	transcription factor MCM1	Saccharomyces cerevisiae S288C	54-59
20625780-1	2011	In this study, we investigated the activating role of Mcm1p at ARG1 during arginine starvation.	Arginine	75-83	argininosuccinate synthase	Saccharomyces cerevisiae S288C	63-67
20625780-3	2011	Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to overcome arginine starvation in the absence of Gcn4p.	Arginine	123-131	transcription factor MCM1	Saccharomyces cerevisiae S288C	48-53
20625780-3	2011	Especially, we provide strong evidence that the Mcm1p binding sites play a positive role in ARG1 transcription to overcome arginine starvation in the absence of Gcn4p.	Arginine	123-131	argininosuccinate synthase	Saccharomyces cerevisiae S288C	92-96
20625780-4	2011	In addition, we found that the Mcm1p binding sites are not only regulated by the presence or absence of arginine but also in the presence or absence of other amino acids.	Arginine	104-112	transcription factor MCM1	Saccharomyces cerevisiae S288C	31-36
20717004-3	2011	In sensitive cancer cells arginine starvation led to the activation of caspase-9, caspase-3 and caspase-7, cleavage of reparation enzyme, polyADP ribosyl polymerase, and DNA fragmentation, which are the typical hallmarks of intrinsic apoptosis realized by the mitochondrial pathway.	Arginine	26-34	caspase 9	Homo sapiens	71-80
20717004-3	2011	In sensitive cancer cells arginine starvation led to the activation of caspase-9, caspase-3 and caspase-7, cleavage of reparation enzyme, polyADP ribosyl polymerase, and DNA fragmentation, which are the typical hallmarks of intrinsic apoptosis realized by the mitochondrial pathway.	Arginine	26-34	caspase 7	Homo sapiens	96-105
21111849-0	2011	Posttranslational arginine methylation of lamin A/C during myoblast fusion.	Arginine	18-26	lamin A/C	Rattus norvegicus	42-51
21106532-2	2011	Recent studies demonstrated that LSS also increases the expression of argininosuccinate synthetase 1 (ASS1) that regulates the provision of L-arginine, the substrate of NOS3.	Arginine	140-150	argininosuccinate synthase 1	Homo sapiens	70-100
21106532-2	2011	Recent studies demonstrated that LSS also increases the expression of argininosuccinate synthetase 1 (ASS1) that regulates the provision of L-arginine, the substrate of NOS3.	Arginine	140-150	argininosuccinate synthase 1	Homo sapiens	102-106
21081503-3	2011	The human PRMT5 complex consists of PRMT5, WD45/MEP50 (WD repeat domain 45/methylosome protein 50), and pICln and catalyzes the symmetrical arginine dimethylation of its substrate proteins.	Arginine	140-148	WD repeat domain 77	Homo sapiens	48-53
21628896-5	2011	In regards to the activity of U II, it is determined that the hydrophobic Phe-6 plays a more critical role than Gly-8 or Arg-10.	Arginine	121-124	urotensin 2	Homo sapiens	30-34
21691091-0	2011	Integrin signaling modulates AQP2 trafficking via Arg-Gly-Asp (RGD) motif.	Arginine	50-53	aquaporin 2	Homo sapiens	29-33
21196403-4	2011	Of particular interest, recent proteomics analysis has shown that treatment of coronary venular endothelial cells with a physiological level of L-arginine (e.g., 0.1 mM) increases expression of structural proteins (vimentin and tropomyosin) and cytochrome bc1 complex iii-chain A, while decreasing expression of stress-related proteins (PDZ domain containing-3), in these cells.	Arginine	144-154	vimentin	Homo sapiens	215-223
21297920-4	2011	Under these circumstances, the cells exhibited global protein arginine methylation: this event was also reproduced by the cell treatment with hemin, a heme oxygenase-1 inducer.	Arginine	62-70	heme oxygenase 1	Homo sapiens	151-167
21151117-2	2011	Seeking to exploit antibody fragments as RNA crystallization chaperones, we have used an arginine-enriched synthetic Fab library displayed on phage to obtain Fabs against the class I ligase ribozyme.	Arginine	89-97	FA complementation group B	Homo sapiens	117-120
22132110-4	2011	Neutralizing antibody to integrin alphavbeta3 and an integrin-binding Arg-Gly-Asp (RGD) peptide blocked thyroid hormone-induced PCNA expression.	Arginine	70-73	proliferating cell nuclear antigen	Homo sapiens	128-132
21731701-1	2011	Peptidylarginine deiminase 4 (PAD4) is a homodimeric enzyme that catalyzes Ca2+-dependent protein citrullination, which results in the conversion of arginine to citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
20937842-5	2010	In the present work, we show that matriptase-2 cleaves HJV at Arg(288), which produces one major soluble form of HJV.	Arginine	62-65	hemojuvelin BMP co-receptor	Homo sapiens	55-58
20937842-5	2010	In the present work, we show that matriptase-2 cleaves HJV at Arg(288), which produces one major soluble form of HJV.	Arginine	62-65	hemojuvelin BMP co-receptor	Homo sapiens	113-116
20841502-5	2010	Addition of arginine increased the activation of mTOR, p70 ribosomal protein S6 (p70 S6) kinase, and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) in a time- and dose-dependent manner.	Arginine	12-20	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	152-158
20977583-4	2010	Genotyping of the IRS-1 Arg(972) variant was performed in type 2 diabetes patients treated with either sulphonylurea drugs, glinides or insulin or with metformin, acarbose or glitazones using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.	Arginine	24-27	insulin receptor substrate 1	Homo sapiens	18-23
20977583-7	2010	CONCLUSIONS: Thus, we were able to replicate the earlier findings of an association between the IRS-1 Arg(972) variant and secondary failure to sulphonylurea drugs, and further observed a general association between HbA1c and this polymorphism in type 2 diabetes patients treated with insulinotropic hypoglycaemic drugs but not with metformin.	Arginine	102-105	insulin receptor substrate 1	Homo sapiens	96-101
20805789-4	2010	Arginosuccinate synthetase (ASS) and arginosuccinate lyase (ASL) convert L-citrulline to L-arginine; L-citrulline is regenerated during NO synthesis from L-arginine.	Arginine	89-99	argininosuccinate lyase	Rattus norvegicus	37-58
20805789-4	2010	Arginosuccinate synthetase (ASS) and arginosuccinate lyase (ASL) convert L-citrulline to L-arginine; L-citrulline is regenerated during NO synthesis from L-arginine.	Arginine	89-99	argininosuccinate lyase	Rattus norvegicus	60-63
20805789-4	2010	Arginosuccinate synthetase (ASS) and arginosuccinate lyase (ASL) convert L-citrulline to L-arginine; L-citrulline is regenerated during NO synthesis from L-arginine.	Arginine	154-164	argininosuccinate lyase	Rattus norvegicus	37-58
20805789-4	2010	Arginosuccinate synthetase (ASS) and arginosuccinate lyase (ASL) convert L-citrulline to L-arginine; L-citrulline is regenerated during NO synthesis from L-arginine.	Arginine	154-164	argininosuccinate lyase	Rattus norvegicus	60-63
21105926-6	2010	Taking advantage of the in vivo AGD5-ARF1 interaction at the TGN, we show that mutation of an arginine residue that is critical for ARF-GAP activity of AGD5 leads to longer residence of ARF1 on the membranes, as expected if GTP hydrolysis on ARF1 was impaired due to a defective GAP.	Arginine	94-102	auxin response factor 1	Arabidopsis thaliana	37-41
21105926-6	2010	Taking advantage of the in vivo AGD5-ARF1 interaction at the TGN, we show that mutation of an arginine residue that is critical for ARF-GAP activity of AGD5 leads to longer residence of ARF1 on the membranes, as expected if GTP hydrolysis on ARF1 was impaired due to a defective GAP.	Arginine	94-102	auxin response factor 1	Arabidopsis thaliana	186-190
21105926-6	2010	Taking advantage of the in vivo AGD5-ARF1 interaction at the TGN, we show that mutation of an arginine residue that is critical for ARF-GAP activity of AGD5 leads to longer residence of ARF1 on the membranes, as expected if GTP hydrolysis on ARF1 was impaired due to a defective GAP.	Arginine	94-102	auxin response factor 1	Arabidopsis thaliana	186-190
20858712-4	2010	SNP1 (rs35235055) results in a leucine-to-proline substitution (Leu(23)Pro), while SNP2 (rs35623192) results in an arginine-to-cysteine substitution (Arg(340)Cys).	Arginine	115-123	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	0-4
20805223-7	2010	Modest overexpression of OGT alters mitotic histone post-translational modifications at Lys-9, Ser-10, Arg-17, and Lys-27 of histone H3.	Arginine	103-106	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	25-28
20817944-6	2010	Plasma membrane NAPDH oxidase activity was reduced in neutrophils expressing p47(phox) with Arg(90) substitutions, with substantial effects on responses to either phorbol ester or formyl-Met-Leu-Phe and more modest effects to particulate stimuli.	Arginine	92-95	pleckstrin	Homo sapiens	77-80
20817944-7	2010	In contrast, p47(phox) Arg(90) mutants supported normal levels of intracellular NADPH oxidase activity during phagocytosis of a variety of particles and were recruited to phagosome membranes.	Arginine	23-26	pleckstrin	Homo sapiens	13-16
20962777-3	2010	Here we show that PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5), which transfers methyl groups to arginine residues present in histones and Sm spliceosomal proteins, links the circadian clock to the control of alternative splicing in plants.	Arginine	98-106	capsuleen	Drosophila melanogaster	18-55
20962777-3	2010	Here we show that PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5), which transfers methyl groups to arginine residues present in histones and Sm spliceosomal proteins, links the circadian clock to the control of alternative splicing in plants.	Arginine	98-106	capsuleen	Drosophila melanogaster	57-62
21268344-1	2010	The ability of novel cell-permeating peptide molecules derived from the peptide inhibitor of the myosin light chain kinase (MLCK) L-PIK (Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys) to inhibit this kinase in vitro and attenuate the thrombin-induced hyperpermeability of endothelial cell monolayer in culture has been studied.	Arginine	137-140	myosin light chain kinase	Homo sapiens	97-122
21268344-1	2010	The ability of novel cell-permeating peptide molecules derived from the peptide inhibitor of the myosin light chain kinase (MLCK) L-PIK (Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys) to inhibit this kinase in vitro and attenuate the thrombin-induced hyperpermeability of endothelial cell monolayer in culture has been studied.	Arginine	137-140	myosin light chain kinase	Homo sapiens	124-128
20889542-0	2010	L-arginine deprivation regulates cyclin D3 mRNA stability in human T cells by controlling HuR expression.	Arginine	0-10	ELAV like RNA binding protein 1	Homo sapiens	90-93
20889542-6	2010	RNA-binding protein HuR was found to be increased in T cells cultured in medium with L-Arg and bound to the 3"-untranslated region of cyclin D3 mRNA in vitro and endogenously in activated T cells.	Arginine	85-90	ELAV like RNA binding protein 1	Homo sapiens	20-23
20724949-3	2010	OBJECTIVE: To determine the effect of oral arginine intake on FENO in sickle cell patients with and without history of ACS, and in healthy controls.	Arginine	43-51	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	119-122
20724949-8	2010	ACS- and ACS+ groups were deficient in arginine, and had decreased FEV1, FVC, and SaO2 when compared with HC patients.	Arginine	39-47	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	0-12
20639906-3	2010	Recently, we identified the SR (Ser-Rich/Arg) protein SC35, a splicing factor, as a new transcriptional target of E2F1.	Arginine	41-44	E2F transcription factor 1	Homo sapiens	114-118
20818810-6	2010	RESULTS: alpha,beta-amyrin and methylprednisolone treatments significantly (P &lt; 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-alpha and IL-6, as compared to the vehicle control.	Arginine	104-114	lipase G, endothelial type	Rattus norvegicus	223-229
20506214-8	2010	Incubation of wild-type P gingivalis with fibrinogen or alpha-enolase caused degradation of the proteins and citrullination of the resulting peptides at carboxy-terminal arginine residues, which were identified by mass spectrometry.	Arginine	170-178	enolase 1	Homo sapiens	56-69
20421892-6	2010	Furthermore, PRMT5 methylates N-terminal arginines in GM130, and such arginine methylation appears critical for GA ribbon formation.	Arginine	41-50	golgin A2	Homo sapiens	54-59
20421892-6	2010	Furthermore, PRMT5 methylates N-terminal arginines in GM130, and such arginine methylation appears critical for GA ribbon formation.	Arginine	41-49	golgin A2	Homo sapiens	54-59
20421892-7	2010	Our findings reveal a molecular mechanism by which PRMT5-dependent arginine methylation of GM130 controls the maintenance of GA architecture.	Arginine	67-75	golgin A2	Homo sapiens	91-96
20827430-5	2010	In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity.	Arginine	112-115	glutathione S-transferase pi 1	Homo sapiens	329-334
20601429-9	2010	Three matriptase recognition sites were identified in ASIC1 (Arg-145, Lys-185, and Lys-384).	Arginine	61-64	acid sensing ion channel subunit 1	Homo sapiens	54-59
20529840-3	2010	We investigated its importance in neuronal NOS (nNOS) by mutating the two residues that primarily create the bridging interaction (Arg(752) in the FMN subdomain and Glu(47) in CaM).	Arginine	131-134	formin 1	Homo sapiens	147-150
20684070-3	2010	JMJD6 catalyses the iron- and 2-oxoglutarate-dependent hydroxylation of lysyl residues in arginine-serine-rich domains of RNA splicing-related proteins.	Arginine	90-98	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	Homo sapiens	0-5
20511413-9	2010	The serum arginine concentration was decreased (124.3 + or - 5.6 vs. 155.4 + or - 12.0 micromol/l in sham; P &lt; 0.05) at a time when cardiac arginase II expression was increased (0.06 + or - 0.01 vs. 0.02 + or - 0.01 arbitrary units in sham; P &lt; 0.05).	Arginine	10-18	arginase-2, mitochondrial	Oryctolagus cuniculus	143-154
20730725-6	2010	RESULTS: The genotype and allele distribution of Trp64Arg polymorphism in the beta3-AR gene were significantly different among each sporting discipline, showing the highest Arg allele frequency in volleyball and gymnastics (p &lt; 0.05).	Arginine	54-57	adrenoceptor beta 3	Homo sapiens	78-86
20582959-13	2010	CD3zeta chain expression increased after addition of L-Arg in both groups; differences were insignificant.	Arginine	53-58	CD247 molecule	Homo sapiens	0-13
20562214-0	2010	Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. Mammalian cleavage factor I (CF I(m)) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF I(m)25, CF I(m)59, CF I(m)68).	Arginine	0-8	cleavage and polyadenylation specific factor 6	Homo sapiens	211-220
20562214-6	2010	As sites of methylation in CF I(m)68 we could exclusively identify arginines in a GGRGRGRF or "GAR" motif that is conserved in vertebrates.	Arginine	67-76	cleavage and polyadenylation specific factor 6	Homo sapiens	27-36
20513808-5	2010	IDH1 and IDH2 mutations are remarkably specific to codons that encode conserved functionally important arginines in the active site of each enzyme.	Arginine	103-112	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
19684306-7	2010	Membrane binding of CCTalpha decreased gradually as the number of positively charged arginine residues increased in the VEEKS motif.	Arginine	85-93	phosphate cytidylyltransferase 1, choline, alpha isoform	Mus musculus	20-28
20368351-7	2010	Genetic substitution of arginine 138, which is part of a three-dimensional protein motif for binding to lipid A phosphates, decreased both the enzymatic activity of His(6)-Pla and the amount of Pla in Y. pestis cells, suggesting the importance of the Pla-lipid A phosphate interaction.	Arginine	24-32	plasminogen activator protease precursor	Yersinia pestis	172-175
20368351-7	2010	Genetic substitution of arginine 138, which is part of a three-dimensional protein motif for binding to lipid A phosphates, decreased both the enzymatic activity of His(6)-Pla and the amount of Pla in Y. pestis cells, suggesting the importance of the Pla-lipid A phosphate interaction.	Arginine	24-32	plasminogen activator protease precursor	Yersinia pestis	194-197
20368351-7	2010	Genetic substitution of arginine 138, which is part of a three-dimensional protein motif for binding to lipid A phosphates, decreased both the enzymatic activity of His(6)-Pla and the amount of Pla in Y. pestis cells, suggesting the importance of the Pla-lipid A phosphate interaction.	Arginine	24-32	plasminogen activator protease precursor	Yersinia pestis	194-197
20200118-4	2010	Recently, three arginine residues within the large intracellular loop of the 5-HT(3A) subunit were substituted by their equivalent residues (glutamine, aspartate, and alanine) of the 5-HT(3B) subunit to produce a 5-HT(3A)(QDA) subunit that forms functional homomeric channels exhibiting a measurable single-channel conductance.	Arginine	16-24	5-hydroxytryptamine receptor 3B	Homo sapiens	183-190
20392839-6	2010	Co-overexpression of ER/Golgi arginine soluble N-ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) specifically rescued transport, indicating that alpha-synuclein antagonizes SNARE function.	Arginine	30-38	synuclein alpha	Homo sapiens	169-184
20226781-4	2010	Crystal structure and biochemical analyses revealed that an R233H substitution mutation in zebrafish uxs1 alters an arginine buried in the dimer interface, thereby destabilizing and, as enzyme assays show, inactivating the enzyme.	Arginine	116-124	UDP-glucuronate decarboxylase 1	Danio rerio	101-105
20385800-6	2010	Using a model of the N-terminal domain of the alpha1 GlyR, we hypothesized that an arginine-119 residue was forming intersubunit electrostatic bonds with D97.	Arginine	83-91	glycine receptor alpha 1	Homo sapiens	46-57
20154084-1	2010	Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a novel conserved Phe-Arg-Arg-Gly motif and function in autophagy-related pathways.	Arginine	107-110	WD repeat domain, phosphoinositide interacting 1	Homo sapiens	0-5
20064924-6	2010	The model G-quadruplex RNA sc1 required arginines 533 and 538 for normal association with FMRP, whereas AATYK mRNA did not.	Arginine	40-49	spinal cord QTL 1	Mus musculus	27-30
20064924-7	2010	In vitro methylation of FMRP-bearing arginine substitutions inhibited sc1 binding but not AATYK binding.	Arginine	37-45	spinal cord QTL 1	Mus musculus	70-73
20144956-7	2010	MPO activity and TNF-alpha expression in lung were upregulated in the ANP rats and further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively.	Arginine	121-126	myeloperoxidase	Rattus norvegicus	0-3
20067571-3	2010	Wild type (wt) mouse Sho consists of an arginine-rich region, a hydrophobic central domain of five tandem A/LAAG amino acid repeats R1-R5 with similarity to the hydrophobic domain of PrP(C), and a C-terminal domain with one N-linked carbohydrate.	Arginine	40-48	shadow of prion protein	Mus musculus	21-24
20300016-7	2010	Because there was no between-group difference in the remaining hormone levels, it appears that the GH/IGF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation.	Arginine	214-217	insulin like growth factor binding protein 3	Homo sapiens	108-115
20237569-7	2010	Finally, the comparison of Ca(2+)-binding CUB domains and the low-density lipoprotein (LDL) receptor-type A modules suggests that the electrostatic pairing of a basic ligand arginine/lysine residue with Ca(2+)-coordinating acidic aspartates/glutamates is a common theme of Ca(2+)-dependent ligand-receptor interactions.	Arginine	174-182	low density lipoprotein receptor	Homo sapiens	62-100
20375004-2	2010	We report that stiff skin syndrome (SSS), an autosomal dominant congenital form of scleroderma, is caused by mutations in the sole Arg-Gly-Asp sequence-encoding domain of fibrillin-1 that mediates integrin binding.	Arginine	131-134	fibrillin 1	Homo sapiens	171-182
20071328-3	2010	Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties.	Arginine	93-96	secreted phosphoprotein 1	Homo sapiens	140-143
20071328-6	2010	Six cleavages cannot be ascribed to thrombin or matrix metalloproteinase activity, whereas the cleavage at Arg(152)-Ser(153) matches thrombin specificity for OPN.	Arginine	107-110	secreted phosphoprotein 1	Homo sapiens	158-161
20048145-8	2010	Unlike PKAc, which requires Arg-95 and -96 in the pseudosubstrate region of PKARIalpha for their interactions, RSK1/PKARIalpha association requires all four Arg residues (Arg-93-96) in the pseudosubstrate site of PKARIalpha.	Arginine	157-160	ribosomal protein S6 kinase A1	Homo sapiens	111-115
20048145-8	2010	Unlike PKAc, which requires Arg-95 and -96 in the pseudosubstrate region of PKARIalpha for their interactions, RSK1/PKARIalpha association requires all four Arg residues (Arg-93-96) in the pseudosubstrate site of PKARIalpha.	Arginine	157-160	ribosomal protein S6 kinase A1	Homo sapiens	111-115
20060040-4	2010	The predicted amino acid sequence has 380 amino acids including an arginine-serine-rich region, which is characteristic of insect orthologs of Tra.	Arginine	67-75	transformer	Drosophila melanogaster	143-146
19969318-3	2010	We have previously shown that EBNA2 contains symmetrically dimethylated Arginine (sDMA) residues.	Arginine	72-80	EBNA-2	Human gammaherpesvirus 4	30-35
20142433-2	2010	IDH1/2 mutations are heterozygous, and affect a single arginine residue.	Arginine	55-63	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-6
19828345-7	2010	In addition, a mutant LDLR, which has the three lysines in the intracellular domain substituted with arginines, was also degraded by D374Y-PCSK9.	Arginine	101-110	low density lipoprotein receptor	Homo sapiens	22-26
19828345-7	2010	In addition, a mutant LDLR, which has the three lysines in the intracellular domain substituted with arginines, was also degraded by D374Y-PCSK9.	Arginine	101-110	proprotein convertase subtilisin/kexin type 9	Homo sapiens	139-144
19852066-3	2010	The substitution of B13 leucine with arginine in the beta globin results in alteration of a critical heme contact point resulting in an extremely unstable variant hemoglobin and a clinical picture that is characterized by ineffective erythropoiesis and numerous intracytoplasmic inclusions within the erythrocyte precursors of the bone marrow.	Arginine	37-45	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	20-23
19852066-3	2010	The substitution of B13 leucine with arginine in the beta globin results in alteration of a critical heme contact point resulting in an extremely unstable variant hemoglobin and a clinical picture that is characterized by ineffective erythropoiesis and numerous intracytoplasmic inclusions within the erythrocyte precursors of the bone marrow.	Arginine	37-45	hemoglobin subunit beta	Homo sapiens	53-64
20220325-4	2010	A functional human leptin receptor gene (LEPR) polymorphism, a glutamine to an arginine substitution at codon 223 (Gln223Arg), has been associated with insulin resistance capacity and an altered leptin-binding activity.	Arginine	79-87	leptin receptor	Homo sapiens	19-34
20220325-4	2010	A functional human leptin receptor gene (LEPR) polymorphism, a glutamine to an arginine substitution at codon 223 (Gln223Arg), has been associated with insulin resistance capacity and an altered leptin-binding activity.	Arginine	79-87	leptin receptor	Homo sapiens	41-45
20220325-4	2010	A functional human leptin receptor gene (LEPR) polymorphism, a glutamine to an arginine substitution at codon 223 (Gln223Arg), has been associated with insulin resistance capacity and an altered leptin-binding activity.	Arginine	79-87	leptin	Homo sapiens	19-25
19283445-4	2010	Increased plasma gamma-glutamyltransferase and alkaline phosphatase activity and increased bile-acids and bilirubin levels in BDL rats were reduced by administration of L-arginine (P &lt; 0.001).	Arginine	169-179	gamma-glutamyltransferase 1	Rattus norvegicus	17-42
20186852-5	2010	We sequenced FHL1 and identified a new missense mutation within the third LIM domain that replaces a highly conserved cysteine by an arginine (c.625T&gt;C; p.C209R).	Arginine	133-141	four and a half LIM domains 1	Homo sapiens	13-17
21182780-7	2010	RESULTS: In total about two-thirds of the 81 arginines of human fibrinogen were found to be susceptible to citrullination by the human PAD2, the human PAD4 or the rabbit PAD2 enzymes.	Arginine	45-54	peptidyl arginine deiminase 4	Homo sapiens	151-155
19968269-2	2010	Polyacridine peptides of the general formula (Acr-X)(n)-Cys were prepared by solid-phase peptide synthesis, where Acr is Lys modified on its epsilon-amine with acridine, X is Arg, Leu, or Lys and n is 2, 3, or 4 repeats.	Arginine	175-178	acrosin	Homo sapiens	114-117
20606325-2	2010	CPR removes the C-terminal arginine from inflammatory peptides such as C3a and C5a, bradykinin, enkephalin, and the thrombin-cleaved N-terminal fragment osteopontin (cleaved N-OPN).	Arginine	27-35	carboxypeptidase B2 (plasma)	Mus musculus	0-3
21150109-3	2010	In this study, mature MMP-7 was expressed in Escherichia coli as inclusion bodies, solubilized, and refolded with 1 M L-arginine.	Arginine	118-128	matrix metallopeptidase 7	Homo sapiens	22-27
19249120-1	2010	High Mphi:T cell ratios suppress the immune response to the retroviral superantigen Mls by IFNgamma-triggered production of the arg- and trp-consuming enzymes iNOS and IDO.	Arginine	128-131	inositol-3-phosphate synthase 1	Homo sapiens	159-163
20635792-4	2010	Exon-specific amplification of genomic DNA by polymerase chain reaction followed by direct sequence analysis revealed a novel homozygous missense mutation at codon 48 in the C1q C gene causing a glycine-to-arginine substitution affecting the collagen-like region of C1q.	Arginine	206-214	complement C1q A chain	Homo sapiens	174-177
19666909-5	2010	In this respect, the activation of a cAMP-independent and cGMP-dependent pathway for AQP2 membrane insertion by different cyclic guanosine monophosphate (cGMP) pathway activators, such as atrial natriuretic peptide (ANP), l-arginine and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP), has been put forward.	Arginine	222-232	aquaporin 2	Mus musculus	85-89
19666909-10	2010	RESULTS: ANP, l-arginine and 8-Br-cGMP induced the translocation of AQP2 in the mpkCCD cells.	Arginine	14-24	aquaporin 2	Mus musculus	68-72
20044438-9	2009	In our structural homology/molecular dynamics modeling, Tyr-91 in ltp5-1, replacing Val-91 in LTP5, was predicted to interact with Arg-45 and Tyr-81, which are known to interact with a lipid ligand in maize (Zea mays) LTP.	Arginine	131-134	lipid transfer protein 5	Arabidopsis thaliana	66-72
20044438-9	2009	In our structural homology/molecular dynamics modeling, Tyr-91 in ltp5-1, replacing Val-91 in LTP5, was predicted to interact with Arg-45 and Tyr-81, which are known to interact with a lipid ligand in maize (Zea mays) LTP.	Arginine	131-134	lipid transfer protein 5	Arabidopsis thaliana	94-98
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Arginine	128-136	HNP1	Homo sapiens	74-79
19897717-6	2009	In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14.	Arginine	165-173	HNP1	Homo sapiens	74-79
19897717-10	2009	BALF from an IPF patient contained ADP-ribosyl-HNP-ornithine as well as mono- and di-ADP-ribosylated HNP-1, consistent with in vivo conversion of arginine to ornithine.	Arginine	146-154	HNP1	Homo sapiens	101-106
19843866-5	2009	The PADI4 gene encodes an enzyme catalyzing the citrullination of arginine residues in proteins, and ectopic expression of p53 or PADI4 induced protein citrullination.	Arginine	66-74	peptidyl arginine deiminase 4	Homo sapiens	4-9
19843866-5	2009	The PADI4 gene encodes an enzyme catalyzing the citrullination of arginine residues in proteins, and ectopic expression of p53 or PADI4 induced protein citrullination.	Arginine	66-74	peptidyl arginine deiminase 4	Homo sapiens	130-135
19843866-7	2009	We found that PADI4 citrullinated the histone chaperone protein, nucleophosmin (NPM1), at the arginine 197 residue in vivo under physiologic conditions.	Arginine	94-102	peptidyl arginine deiminase 4	Homo sapiens	14-19
19846785-2	2009	The arginine-to-tryptophan missense mutation in position 234 (R234W) in the human gene RLBP1 encoding CRALBP compromises visual pigment regeneration and is associated with Bothnia dystrophy.	Arginine	4-12	retinaldehyde binding protein 1	Homo sapiens	87-92
19846785-2	2009	The arginine-to-tryptophan missense mutation in position 234 (R234W) in the human gene RLBP1 encoding CRALBP compromises visual pigment regeneration and is associated with Bothnia dystrophy.	Arginine	4-12	retinaldehyde binding protein 1	Homo sapiens	102-108
19720802-5	2009	RESULTS: Both glucose- and arginine-stimulated insulin secretion in vivo were decreased by approximately 60% in GPR40 knockout fasted and fed mice, without changes in insulin sensitivity.	Arginine	27-35	free fatty acid receptor 1	Mus musculus	112-117
19720802-9	2009	CONCLUSIONS: These results indicate that deletion of GPR40 impairs insulin secretion in vivo not only in response to fatty acids but also to glucose and arginine, without altering intracellular fuel metabolism in islets, via a mechanism that may involve the generation of inositol phosphates downstream of GPR40 activation.	Arginine	153-161	free fatty acid receptor 1	Mus musculus	53-58
19582797-6	2009	Analysis of the optimal complex model reveals that the previously identified immunodominant residues Glu(44) and Arg(45) of beta2m have direct interactions with BBM.1, while Asp(38) exerts its function mainly via stabilization of Arg(45).	Arginine	113-116	beta-2-microglobulin	Homo sapiens	124-130
19582797-6	2009	Analysis of the optimal complex model reveals that the previously identified immunodominant residues Glu(44) and Arg(45) of beta2m have direct interactions with BBM.1, while Asp(38) exerts its function mainly via stabilization of Arg(45).	Arginine	230-233	beta-2-microglobulin	Homo sapiens	124-130
19582797-7	2009	In addition, Arg(81) of beta2m is a newly identified immunodominant residue to have direct interaction with BBM.1.	Arginine	13-16	beta-2-microglobulin	Homo sapiens	24-30
19810804-9	2009	A HopAA1-1 mutant in which the putative catalytic arginine in the GAP-like domain has been replaced with alanine retains its ability to kill yeast and promote the formation of speck lesions by the DeltahopAA1-1DeltaIX mutant, but a HopAA1-1 mutant carrying the FEN polymorphism loses both of these abilities.	Arginine	50-58	hypothetical protein	Pseudomonas syringae pv. tomato str. DC3000	2-10
19810804-9	2009	A HopAA1-1 mutant in which the putative catalytic arginine in the GAP-like domain has been replaced with alanine retains its ability to kill yeast and promote the formation of speck lesions by the DeltahopAA1-1DeltaIX mutant, but a HopAA1-1 mutant carrying the FEN polymorphism loses both of these abilities.	Arginine	50-58	hypothetical protein	Pseudomonas syringae pv. tomato str. DC3000	232-240
19760664-5	2009	We identified a cation-pi interaction between tryptophan and arginine residues in the Switch II of Galpha(i) family proteins that mediates the observed red shift in emission maxima.	Arginine	61-69	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	99-105
19523989-8	2009	Furthermore, the N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain can be excised by DPPIV and recombinant peptidase with DPPIV-like activities.	Arginine	28-31	lamin A/C	Homo sapiens	49-54
19523989-8	2009	Furthermore, the N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain can be excised by DPPIV and recombinant peptidase with DPPIV-like activities.	Arginine	28-31	dipeptidyl peptidase 4	Homo sapiens	101-106
19523989-8	2009	Furthermore, the N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain can be excised by DPPIV and recombinant peptidase with DPPIV-like activities.	Arginine	28-31	dipeptidyl peptidase 4	Homo sapiens	138-143
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	secreted phosphoprotein 1	Homo sapiens	141-146
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	secreted phosphoprotein 1	Homo sapiens	141-144
19701945-0	2009	Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus.	Arginine	38-47	aquaporin 2	Homo sapiens	79-83
19701945-6	2009	Alanine scanning and glutamic acid to arginine exchanges revealed increased function and plasma membrane expression for AQP2-E258K mutants with the following additional changes: Leu259Ala, Arg252Glu, Arg253Glu, or Arg252Ala-Arg254Ala, or for the AQP2 mutant p.Glu258Ala, indicating that the motif RRRxxxK(258)L confers AQP2-E258K retention.	Arginine	38-46	aquaporin 2	Homo sapiens	120-124
19701945-8	2009	In conclusion, our data reveal that the RRRxxxKL motif and repulsion between K258 and the arginine-triplet within this motif are the primary cause of missorting of AQP2-E258K in NDI.	Arginine	90-98	aquaporin 2	Homo sapiens	164-168
19752231-8	2009	A central pocket binds arginine 83, the only Bw4 motif residue essential for KIR3DL1 interaction, similar to the binding of lysine 80 in HLA-C by KIR2DL1.	Arginine	23-31	body weight QTL 4	Mus musculus	45-48
19752231-9	2009	Central to this interaction is a salt bridge between arginine 83 of Bw4 and glutamate 282 of 3DL1, which juxtaposes the functionally influential dimorphism at position 283.	Arginine	53-61	body weight QTL 4	Mus musculus	68-71
19589362-9	2009	The changes in ratios of CCK9 compared to CCK8 are consistent with dual roles of the cathepsin L protease pathway that includes aminopeptidase B to remove NH2-terminal Arg or Lys, and the PC1/3 protease pathway.	Arginine	168-171	cathepsin L	Mus musculus	85-96
19422058-5	2009	The molecular function and structural features of SPINK2 were also investigated by employing the recombinant active and mutant inactive SPINK2 proteins to determine its key P2-P2" (Pro(23)-Arg(24)-His(25)-Phe(26)) active site.	Arginine	189-192	serine peptidase inhibitor Kazal type 2	Homo sapiens	50-56
19422058-6	2009	The inhibition assay results demonstrated that Arg(24) at the P1 site is crucial for the specificity of SPINK2 on target enzyme.	Arginine	47-50	serine peptidase inhibitor Kazal type 2	Homo sapiens	104-110
19533750-2	2009	Down-regulation of expression of argininosuccinate synthetase (ASS1), the rate-limiting enzyme in the biosynthesis of arginine, has been associated with the development of platinum resistance in ovarian cancer treated with platinum-based chemotherapy.	Arginine	118-126	argininosuccinate synthase 1	Homo sapiens	63-67
19533750-4	2009	In addition, expression and epigenetic regulation of ASS1 were analysed in human ovarian cancer cell lines, and ASS1 expression correlated with the ability of the lines to grow in media containing cisplatin, carboplatin or taxol or in arginine-depleted media.	Arginine	235-243	argininosuccinate synthase 1	Homo sapiens	53-57
19533750-4	2009	In addition, expression and epigenetic regulation of ASS1 were analysed in human ovarian cancer cell lines, and ASS1 expression correlated with the ability of the lines to grow in media containing cisplatin, carboplatin or taxol or in arginine-depleted media.	Arginine	235-243	argininosuccinate synthase 1	Homo sapiens	112-116
19586904-9	2009	The results presented above led us to propose that NOS mediates UV-induced eIF2alpha phosphorylation by activation of both PERK and GCN2 via oxidative stress and l-arginine starvation signaling pathways.	Arginine	162-172	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	123-127
19751415-10	2009	In conclusion, there is an inverse relationship between MPO-mediated tyrosine nitration and arginine-ADMA pathway in liver after endotoxemia.	Arginine	92-100	myeloperoxidase	Cavia porcellus	56-59
19559017-6	2009	The substitution of Arg by Cys corresponding to R206C resulted in elimination of DNase Il3 activity.	Arginine	20-23	deoxyribonuclease 1 like 3	Homo sapiens	81-90
19619121-0	2009	Effects of pH and arginine on the solubility and stability of a therapeutic protein (Fibroblast Growth Factor 20): relationship between solubility and stability.	Arginine	18-26	fibroblast growth factor 20	Homo sapiens	85-112
19619121-2	2009	The solubility of FGF-20 strongly depends on pH, arginine concentration and anions present in a buffer system.	Arginine	49-57	fibroblast growth factor 20	Homo sapiens	18-24
19619121-14	2009	The effect of arginine on the solubility and stability of FGF-20 was dominated by the preferential binding interaction.	Arginine	14-22	fibroblast growth factor 20	Homo sapiens	58-64
19592054-7	2009	Finally, L-arginine increased insulin sensitivity index (P &lt; .05) and adiponectin (P &lt; .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels.	Arginine	9-19	C-C motif chemokine ligand 2	Homo sapiens	130-164
19847118-3	2009	The only oxidative pathway described so far comprises nitric oxide synthase (NOS)-like activity, where guanidino-N from L-arginine is oxidized to NO.	Arginine	120-130	putative nitric oxide synthase	Nicotiana tabacum	54-75
19562746-0	2009	Arg-85 and Thr-430 in murine 5-aminolevulinate synthase coordinate acyl-CoA-binding and contribute to substrate specificity.	Arginine	0-3	aminolevulinic acid synthase 1	Mus musculus	29-55
19562746-3	2009	The X-ray crystal structure of ALAS from Rhodobacter capsulatus reveals that the alkanoate component of succinyl-CoA is coordinated by a conserved arginine and a threonine.	Arginine	147-155	aminolevulinic acid synthase 1	Mus musculus	31-35
19502598-5	2009	Two arginine residues (Arg27 and Arg139) are crucial for the binding of endostatin to integrins and to heparin/heparan sulfate, suggesting that endostatin would not bind simultaneously to integrins and to heparan sulfate.	Arginine	4-12	collagen type XVIII alpha 1 chain	Homo sapiens	72-82
19502598-5	2009	Two arginine residues (Arg27 and Arg139) are crucial for the binding of endostatin to integrins and to heparin/heparan sulfate, suggesting that endostatin would not bind simultaneously to integrins and to heparan sulfate.	Arginine	4-12	collagen type XVIII alpha 1 chain	Homo sapiens	144-154
19172319-5	2009	However, detailed comparison of our modeled structure of ZPI/FXa with that of AT3/FXa points to differences in interaction specificity at the reactive center and in the stability of the inhibitory complex, due to the presence of a tyrosine residue at the P1 position in ZPI, instead of the P1 arginine residue in AT3.	Arginine	293-301	serpin family C member 1	Homo sapiens	78-81
19523975-9	2009	In particular, our results indicate that Pro/Pro genotype plays a pivotal role in determining PAI-1 levels in aged subjects, while in Arg carriers PAI-1 levels are associated to the known insulin related determinants.	Arginine	134-137	serpin family E member 1	Homo sapiens	147-152
19515423-7	2009	Altering the subcellular localization of SOCS1 by mutating clusters of arginine residues within the NLS did not affect the inhibition of interferon mediated STAT1 tyrosine-phosphorylation, but surprisingly led to impaired inhibitory activity of STAT mediated reporter gene induction and IFN-gamma induced CD54 regulation.	Arginine	71-79	suppressor of cytokine signaling 1	Homo sapiens	41-46
19497044-2	2009	The HLA-B typing is B*1801, 1832, and the DNA sequence is homozygous with the exception characterized by a nucleotide exchange "C" to "A" at position 505, which, in consequence, replaced arginine at codon 169 (CGC) by serine in the new allele B*1832.	Arginine	187-195	major histocompatibility complex, class I, B	Homo sapiens	4-9
19263424-5	2009	This work presents a method named MASA that combines the support vector machine with the sequence and structural characteristics of proteins to identify methylation sites on lysine, arginine, glutamate, and asparagine.	Arginine	182-190	enolase-phosphatase 1	Homo sapiens	34-38
19362092-8	2009	Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR.	Arginine	108-118	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	0-24
19362092-8	2009	Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR.	Arginine	108-118	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	26-29
19362092-12	2009	In conclusion, l-arginine supplementation corrects local cardiac noradrenergic hyperactivity in the SHR, probably via increased pre-synaptic substrate availability of NOS-sGC-cGMP pathway and reduced tyrosine hydroxylase levels.	Arginine	15-25	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	171-174
19506754-0	2009	Opening the Arg-Glu salt bridge in myosin: computational study.	Arginine	12-15	myosin heavy chain 14	Homo sapiens	35-41
19506754-1	2009	Opening the Arg-Glu salt bridge in myosin, which presumably succeeds the myosin-catalyzed hydrolysis of adenosine triphosphate, was modeled computationally on the basis of the structures corresponding to the enzyme-substrate and enzyme-product complexes found in the quantum mechanics-molecular mechanics simulations.	Arginine	12-15	myosin heavy chain 14	Homo sapiens	35-41
19506754-1	2009	Opening the Arg-Glu salt bridge in myosin, which presumably succeeds the myosin-catalyzed hydrolysis of adenosine triphosphate, was modeled computationally on the basis of the structures corresponding to the enzyme-substrate and enzyme-product complexes found in the quantum mechanics-molecular mechanics simulations.	Arginine	12-15	myosin heavy chain 14	Homo sapiens	73-79
19389712-9	2009	A hyperglycemic clamp revealed increased insulin sensitivity and decreased GSIS and arginine-induced insulin secretion in ATGL(-/-) mice.	Arginine	84-92	patatin-like phospholipase domain containing 2	Mus musculus	122-126
19336400-12	2009	In contrast, replacing Arg(82)/Arg(93) in ST8Sia IV with alanine substantially decreased NCAM-specific polysialylation while only partially impacting autopolysialylation, suggesting that these residues may be particularly important for NCAM polysialylation.	Arginine	31-34	neural cell adhesion molecule 1	Homo sapiens	89-93
19307236-4	2009	A significant increased level of DNA aromatic adducts was found related to the fast oxidation-hydrolysis phenotype defined by the polymorphism I462V in CYP1A1, the allele A in IVS1-154C&gt;A of CYP1A2 and the combination Tyrosine-Arginine for Y113H and H139R of EPHX1.	Arginine	230-238	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	194-200
19106217-7	2009	The present findings provide the molecular mechanisms by which insulin resistance and, by extension, reduced GLUT4 content in PM of muscles and WAT take place after chronic administration of Arg, and further suggest a putative role for GH in its genesis, considering its diabetogenic effect.	Arginine	191-194	solute carrier family 2 member 4	Rattus norvegicus	109-114
19377467-0	2009	Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.	Arginine	0-8	capsuleen	Drosophila melanogaster	51-57
19377467-5	2009	We report that the Drosophila homologue of protein methyltransferase 5 (dPRMT5, csul/dart5), which is also the product of a grandchildless gene, is required for arginine methylation of Drosophila Piwi, Ago3 and Aub proteins in vivo.	Arginine	161-169	capsuleen	Drosophila melanogaster	72-78
19377467-5	2009	We report that the Drosophila homologue of protein methyltransferase 5 (dPRMT5, csul/dart5), which is also the product of a grandchildless gene, is required for arginine methylation of Drosophila Piwi, Ago3 and Aub proteins in vivo.	Arginine	161-169	capsuleen	Drosophila melanogaster	85-90
19416167-3	2009	Studies with mutant RXFP1 receptors established that the final 10 amino acids of the C-terminus and Arg(752) in particular are obligatory for the second phase of cAMP signaling.	Arginine	100-103	relaxin family peptide receptor 1	Homo sapiens	20-25
19416171-6	2009	Further receptor mutagenesis showed that activation of the Galpha(i3)-Gbetagamma-PI3K-PKCzeta cAMP pathway by RXFP1 is dependent upon the C-terminal 10 amino acids of the receptor and absolutely requires Arg(752).	Arginine	204-207	relaxin family peptide receptor 1	Homo sapiens	110-115
18804950-3	2009	This diagnosis was confirmed by genetic testing, which revealed a novel point mutation in the COL3A1 gene, c.2545G--&gt;C, leading to a codon encoding for arginine instead of glycine (p.Gly849Arg).	Arginine	155-163	collagen type III alpha 1 chain	Homo sapiens	94-100
19135027-5	2009	Using site-directed mutagenesis: i) Arg(334), Arg(396) and Arg(638) were directly assigned to the ETF and ii) Arg(198) was assigned as the only tryptic site to the LTF.	Arginine	36-39	TEA domain transcription factor 2	Homo sapiens	98-101
19135027-5	2009	Using site-directed mutagenesis: i) Arg(334), Arg(396) and Arg(638) were directly assigned to the ETF and ii) Arg(198) was assigned as the only tryptic site to the LTF.	Arginine	46-49	TEA domain transcription factor 2	Homo sapiens	98-101
19135027-5	2009	Using site-directed mutagenesis: i) Arg(334), Arg(396) and Arg(638) were directly assigned to the ETF and ii) Arg(198) was assigned as the only tryptic site to the LTF.	Arginine	46-49	TEA domain transcription factor 2	Homo sapiens	98-101
19135027-5	2009	Using site-directed mutagenesis: i) Arg(334), Arg(396) and Arg(638) were directly assigned to the ETF and ii) Arg(198) was assigned as the only tryptic site to the LTF.	Arginine	46-49	TEA domain transcription factor 2	Homo sapiens	98-101
19135027-6	2009	Arg(671), Lys(712)/Lys(713) and Lys(728) were also found to modulate the ETF.	Arginine	0-3	TEA domain transcription factor 2	Homo sapiens	73-76
19290927-7	2009	Abl/Arg double null T cells exhibit impaired TCR-induced signaling, proliferation, and cytokine production.	Arginine	4-7	T cell receptor alpha variable 6-3	Mus musculus	45-48
19689280-3	2009	In fact, unfractionated heparin (UFH) binds to ATIII lysine site leading to a conformational change of the ATIII arginine reactive centre able to create a covalent binding to the active centre serine of thrombin in a ternary complex formation composed by heparin, ATIII and thrombin.	Arginine	113-121	serpin family C member 1	Homo sapiens	107-112
18354387-7	2009	With a non-synonymous G to A transition, rs2734849 produces an amino-acid change (arginine to histidine) in C-terminal ankyrin repeat domain of ANKK1.	Arginine	82-90	ankyrin repeat and kinase domain containing 1	Homo sapiens	144-149
19508226-1	2009	Peptidylarginine deiminase IV (PAD4) catalyzes the conversion of an Arg residue to a citrulline residue in various proteins.	Arginine	68-71	peptidyl arginine deiminase 4	Homo sapiens	31-35
19140837-2	2009	The HLA-B*4081 allele shows one nucleotide difference from B*400101 in exon 2 at nucleotide position 124 where G--&gt;C (codon 18 GGG--&gt;CGG) resulting in a coding change, 18Gly is changed to Arg, this is a unique nucleotide change among the HLA class I alleles, suggesting a point mutation mechanism.	Arginine	194-197	major histocompatibility complex, class I, B	Homo sapiens	4-9
18929572-9	2008	Finally, our structural studies have allowed us to model the conformation of a conserved loop (pore loop 2) that is predicted to form an arginine-rich pore at the center of one of the Vps4 hexameric rings.	Arginine	137-145	AAA family ATPase VPS4	Saccharomyces cerevisiae S288C	184-188
18929572-10	2008	Our mutational analyses demonstrate that pore loop 2 residues Arg241 and Arg251 are required for efficient HIV-1 budding, thereby supporting a role for this "arginine collar" in Vps4 function.	Arginine	158-166	AAA family ATPase VPS4	Saccharomyces cerevisiae S288C	178-182
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Arginine	114-122	N-acetylglucosamine kinase	Homo sapiens	206-230
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Arginine	114-122	N-acetylglucosamine kinase	Homo sapiens	232-236
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Arginine	164-172	N-acetylglucosamine kinase	Homo sapiens	206-230
19013524-1	2008	When nitrogen is abundant, prokaryotic and eukaryotic oxygen-producing photosynthetic organisms store nitrogen as arginine, by relieving feedback inhibition of the arginine biosynthesis controlling enzyme, N-acetylglutamate kinase (NAGK).	Arginine	164-172	N-acetylglucosamine kinase	Homo sapiens	232-236
19013524-6	2008	Each PII subunit contacts one NAGK subunit, triggering a symmetry-restricted narrowing of the NAGK ring, with concomitant adoption by the arginine sites of a low-affinity conformation.	Arginine	138-146	N-acetylglucosamine kinase	Homo sapiens	30-34
18761428-4	2008	The second is a heteroplasmic insertion of 1-6 adenine nucleotides in the A-tract of the tRNA arginine gene (tRNA-Arg; mt-Tr) at positions 9821-9826.	Arginine	114-117	tRNA arginine, mitochondrial	Mus musculus	119-124
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	adrenoceptor alpha 1D	Homo sapiens	65-71
18937499-5	2008	In particular, residue 120 (Arg in IFN-alpha2; Lys in IFN-alpha2/alpha1) appears to be a "hot-spot" residue: substitution by alanine significantly decreased biological activity, and the charge-reversal mutation of residue 120 to Glu caused drastic loss of antiviral and antiproliferative activity for both IFN-alpha2 and IFN-alpha2/alpha1.	Arginine	28-31	adrenoceptor alpha 1D	Homo sapiens	332-338
19017403-3	2008	An A to G transition mutation in codon 223 in exon 6 of the leptin receptor gene, resulting in glutamine to arginine substitution (Gln223Arg), lies within the first of two putative leptin-binding regions and may be associated with impaired signaling capacity of the leptin receptor.	Arginine	108-116	leptin receptor	Homo sapiens	60-75
19017403-3	2008	An A to G transition mutation in codon 223 in exon 6 of the leptin receptor gene, resulting in glutamine to arginine substitution (Gln223Arg), lies within the first of two putative leptin-binding regions and may be associated with impaired signaling capacity of the leptin receptor.	Arginine	108-116	leptin	Homo sapiens	60-66
19017403-3	2008	An A to G transition mutation in codon 223 in exon 6 of the leptin receptor gene, resulting in glutamine to arginine substitution (Gln223Arg), lies within the first of two putative leptin-binding regions and may be associated with impaired signaling capacity of the leptin receptor.	Arginine	108-116	leptin receptor	Homo sapiens	266-281
19093029-3	2008	Deimination, the conversion of protein-bound arginine to citrulline, is mediated by the peptidylarginine deiminase (PAD) family of enzymes, of which the PAD2 and PAD4 isoforms are present in myelin.	Arginine	45-53	MMTV LTR integration site 4	Mus musculus	162-166
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Arginine	50-58	interleukin 23 subunit alpha	Homo sapiens	11-14
18680750-6	2008	Binding of p19 to p40 is mediated primarily by an arginine residue on helix D of p19 that forms an extensive charge and hydrogen-bonding network with residues at the base of a pocket on p40.	Arginine	50-58	interleukin 23 subunit alpha	Homo sapiens	81-84
18680750-8	2008	Comparative analysis indicates that the IL-23 and IL-12 complexes "mimic" the network of interactions constituting the central arginine pocket despite p19 and p35 having limited sequence homology.	Arginine	127-135	interleukin 23 subunit alpha	Homo sapiens	40-45
18680750-8	2008	Comparative analysis indicates that the IL-23 and IL-12 complexes "mimic" the network of interactions constituting the central arginine pocket despite p19 and p35 having limited sequence homology.	Arginine	127-135	interleukin 23 subunit alpha	Homo sapiens	151-154
18656486-2	2008	The calcium permeability of AMPA-Rs is controlled by the identity of the amino-acid side chain contributed by each subunit at a key position in the conductance pathway, which can be either a glutamine (Q) or an arginine (R).	Arginine	211-219	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	28-35
18940611-0	2008	Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.	Arginine	94-102	programmed cell death 6 interacting protein	Homo sapiens	56-60
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	programmed cell death 6 interacting protein	Homo sapiens	98-102
18694739-1	2008	Cytokine-induced neutrophil chemoattractant-1 (CINC-1), a member of the ELR+CXC subfamily [ELR motif (glutamic acid-leucine-arginine) adjacent to the cysteine-X-cysteine (CXC) motif located at the N-terminus of the protein], is an acute-phase protein and its synthesis is induced by endogenous and exogenous pyrogens.	Arginine	124-132	C-X-C motif chemokine ligand 1	Rattus norvegicus	0-45
18694739-1	2008	Cytokine-induced neutrophil chemoattractant-1 (CINC-1), a member of the ELR+CXC subfamily [ELR motif (glutamic acid-leucine-arginine) adjacent to the cysteine-X-cysteine (CXC) motif located at the N-terminus of the protein], is an acute-phase protein and its synthesis is induced by endogenous and exogenous pyrogens.	Arginine	124-132	C-X-C motif chemokine ligand 1	Rattus norvegicus	47-53
18645041-3	2008	In this report, we identified a novel naturally occurring posttranslational modification of chemokines, that is, the deimination of arginine at position 5 into citrulline of CXC chemokine ligand 10 (CXCL10) by rabbit PAD and human PAD2.	Arginine	132-140	peptidyl arginine deiminase 4	Homo sapiens	217-220
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	73-81	carboxypeptidase D	Homo sapiens	0-18
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	73-81	carboxypeptidase D	Homo sapiens	20-23
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	73-81	carboxypeptidase M	Homo sapiens	29-47
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	73-81	carboxypeptidase M	Homo sapiens	49-52
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	83-86	carboxypeptidase D	Homo sapiens	0-18
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	83-86	carboxypeptidase D	Homo sapiens	20-23
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	83-86	carboxypeptidase M	Homo sapiens	29-47
18535109-1	2008	Carboxypeptidase-D (CPD) and carboxypeptidase-M (CPM) release C-terminal arginine (Arg) from polypeptides, and both are present in the plasma membrane.	Arginine	83-86	carboxypeptidase M	Homo sapiens	49-52
18535109-2	2008	Cell-surface CPD increases intracellular Arg, which is converted to nitric oxide (NO).	Arginine	41-44	carboxypeptidase D	Homo sapiens	13-16
18535109-10	2008	In Arg-free medium, annexin-V staining showed that apoptotic MCF-7 cells (approximately 60%) were rescued by Fa-Ala-Arg (25%) or diethylamine/NO (10%).	Arginine	3-6	annexin A5	Homo sapiens	20-29
18535109-15	2008	In summary, PRL/E2-induced cell-surface CPD released Arg from extracellular substrates, increased intracellular NO, promoted survival and inhibited apoptosis of MCF-7 cells.	Arginine	53-56	carboxypeptidase D	Homo sapiens	40-43
18667497-3	2008	Fusing the Tat activation domain to some splicing factors, particularly to the Arg-Ser (RS) domain of U2AF65, creates Tat inhibitors that localize to subnuclear speckles, sites where pre-mRNA processing factors are stored for assembly into transcription complexes.	Arginine	79-82	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	102-108
18614796-6	2008	We propose a model in which dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles, thus acting as a tER scaffold.	Arginine	57-65	uncharacterized protein	Drosophila melanogaster	139-144
18614796-6	2008	We propose a model in which dSec16 binds ER cups via its arginine-rich domain, interacts with Sar1-GTP that is generated on ER membrane by Sec12 and concentrates it in the ER cups where it initiates the formation of COPII vesicles, thus acting as a tER scaffold.	Arginine	57-65	Secretory 23	Drosophila melanogaster	216-221
18614798-6	2008	Arginine-197 in PBR-N was a key residue to regulate subcellular localization of Nox5 and its interaction with PtdIns(4,5)P(2).	Arginine	0-8	NADPH oxidase 5	Homo sapiens	80-84
18660501-3	2008	Knockdown of SLC3A2 in human cells, using short hairpin RNA, caused an increase in putrescine uptake and a decrease in arginine uptake activity.	Arginine	119-127	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	13-19
18275628-9	2008	The 0.5 % Arg increased PPARgamma mRNA abundance in all three intestinal segments (P &lt; 0.10), and 1.0 % Arg increased duodenal PPARgamma mRNA abundance (P = 0.094).	Arginine	10-13	peroxisome proliferator activated receptor gamma	Sus scrofa	24-33
18275628-9	2008	The 0.5 % Arg increased PPARgamma mRNA abundance in all three intestinal segments (P &lt; 0.10), and 1.0 % Arg increased duodenal PPARgamma mRNA abundance (P = 0.094).	Arginine	107-110	peroxisome proliferator activated receptor gamma	Sus scrofa	130-139
18275628-11	2008	Additionally, it is possible that the protective effects of Arg on the intestine are associated with decreasing the expression of intestinal pro-inflammatory cytokines through activating PPARgamma expression.	Arginine	60-63	peroxisome proliferator activated receptor gamma	Sus scrofa	187-196
18534978-4	2008	Mutations of three arginine residues on these loops cause decreased TREX2 activities by up to 60-fold.	Arginine	19-27	three prime repair exonuclease 2	Homo sapiens	68-73
18534978-5	2008	Steady-state kinetic assays of these arginine to alanine TREX2 variants result in increased K(m) values for DNA substrate with no effect on k(cat) values indicating contributions exclusively to DNA binding by all three of the loop arginines.	Arginine	37-45	three prime repair exonuclease 2	Homo sapiens	57-62
18534978-5	2008	Steady-state kinetic assays of these arginine to alanine TREX2 variants result in increased K(m) values for DNA substrate with no effect on k(cat) values indicating contributions exclusively to DNA binding by all three of the loop arginines.	Arginine	231-240	three prime repair exonuclease 2	Homo sapiens	57-62
18247344-11	2008	The chemical shift perturbation and the cross saturation experiments of the human ACC2 holo-biotinoyl upon the addition of the biotin ligase (BirA) showed the interaction surface near the MKM motif, the two glutamic acids (Glu 926, Glu 953), and the positively charged residues (several lysine and arginine residues).	Arginine	298-306	acetyl-CoA carboxylase beta	Homo sapiens	82-86
18492485-3	2008	Insulin enhanced arginine methylation of a 66-kDa protein (p66) concomitant with translocation of PRMT1 to the membrane fraction.	Arginine	17-25	DNA polymerase delta 3, accessory subunit	Homo sapiens	59-62
18628823-0	2008	PKCepsilon stimulated arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation.	Arginine	22-30	protein kinase C epsilon	Homo sapiens	0-10
18628823-3	2008	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we determined the activated PKCepsilon as the specific trigger for RIP140 arginine methylation and its subsequent export.	Arginine	121-129	protein kinase C epsilon	Homo sapiens	75-85
19587776-1	2008	Protein arginine deiminase 4 (PAD4) is an enzyme that hydrolyzes peptidyl arginine residues to form citrulline and ammonia.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
18567752-6	2008	Dietary supplementation with 0.7% L-arginine also increased (P &lt; 0.05) immunoreactive expression of CD34 in duodenal submucosa, ileal mucosa and submucosa, and expression of vascular endothelial growth factor (VEGF) in duodenal submucosa, jejunal mucosa and submucosa, and ileal mucosa compared with the control and 1.2% L-arginine supplementation.	Arginine	34-44	vascular endothelial growth factor A	Sus scrofa	177-211
18567752-6	2008	Dietary supplementation with 0.7% L-arginine also increased (P &lt; 0.05) immunoreactive expression of CD34 in duodenal submucosa, ileal mucosa and submucosa, and expression of vascular endothelial growth factor (VEGF) in duodenal submucosa, jejunal mucosa and submucosa, and ileal mucosa compared with the control and 1.2% L-arginine supplementation.	Arginine	34-44	vascular endothelial growth factor A	Sus scrofa	213-217
18567752-8	2008	Immunoexpression of VEGF in duodenal mucosa and plasma lysine concentrations on d 6 and 10 were lower (P &lt; 0.05) in pigs supplemented with 1.2% L-arginine than in unsupplemented pigs.	Arginine	147-157	vascular endothelial growth factor A	Sus scrofa	20-24
18424033-7	2008	The increased XO and MPO activities and MDA levels significantly decreased in exercised rats that were fed a diet supplemented with L-Arg.	Arginine	132-137	myeloperoxidase	Rattus norvegicus	21-24
18364727-1	2008	Osteopontin (OPN), a large secreted glycoprotein with an arginine, glycine, aspartate (RGD) motif, can bind and signal through cellular integrin receptors.	Arginine	57-65	secreted phosphoprotein 1	Homo sapiens	0-11
18364727-1	2008	Osteopontin (OPN), a large secreted glycoprotein with an arginine, glycine, aspartate (RGD) motif, can bind and signal through cellular integrin receptors.	Arginine	57-65	secreted phosphoprotein 1	Homo sapiens	13-16
18577015-8	2008	The nutritional properties of sample showed that enrichment of semolina with MPI had a pronounced effect on lysine, cysteine, arginine, and histidine contents.	Arginine	126-134	mannose phosphate isomerase	Homo sapiens	77-80
18444620-8	2008	B3LYP and MP2 calculations indicate that zwitterionic forms of arginine are lowest in free energy for M = Ca, Sr, and Ba.	Arginine	63-71	tryptase pseudogene 1	Homo sapiens	10-13
18482921-2	2008	Since the frequency of Arg alleles of the beta(3)-AR gene is generally low among many populations, studies on the Arg/Arg genotype in relation to lipid and lipoprotein metabolism are required in countries such as Japan which has a relatively high frequency of the Arg allele.	Arginine	23-26	adrenoceptor beta 3	Homo sapiens	42-52
18482921-2	2008	Since the frequency of Arg alleles of the beta(3)-AR gene is generally low among many populations, studies on the Arg/Arg genotype in relation to lipid and lipoprotein metabolism are required in countries such as Japan which has a relatively high frequency of the Arg allele.	Arginine	114-117	adrenoceptor beta 3	Homo sapiens	42-52
18482921-2	2008	Since the frequency of Arg alleles of the beta(3)-AR gene is generally low among many populations, studies on the Arg/Arg genotype in relation to lipid and lipoprotein metabolism are required in countries such as Japan which has a relatively high frequency of the Arg allele.	Arginine	114-117	adrenoceptor beta 3	Homo sapiens	42-52
18482921-2	2008	Since the frequency of Arg alleles of the beta(3)-AR gene is generally low among many populations, studies on the Arg/Arg genotype in relation to lipid and lipoprotein metabolism are required in countries such as Japan which has a relatively high frequency of the Arg allele.	Arginine	114-117	adrenoceptor beta 3	Homo sapiens	42-52
18482921-8	2008	Multiple regression analysis, using LDL-C concentration as a criterion variable and some factors including beta(3)-AR gene polymorphism as explanatory variables, revealed that the number of Arg alleles was a significant and independent factor for LDL-C concentrations, along with age and BMI.	Arginine	190-193	adrenoceptor beta 3	Homo sapiens	107-117
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	209-212	adrenoceptor beta 3	Homo sapiens	52-62
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	213-216	adrenoceptor beta 3	Homo sapiens	52-62
18482921-9	2008	CONCLUSIONS: These findings suggested a role of the beta(3)-AR gene polymorphism in regulating lipid and lipoprotein metabolism, showing small but significant effects on elevated LDL-C values in subjects with Arg/Arg, but not Trp/Arg and Trp/Trp genotypes.	Arginine	213-216	adrenoceptor beta 3	Homo sapiens	52-62
18419821-0	2008	Ornithine-delta-aminotransferase is essential for arginine catabolism but not for proline biosynthesis.	Arginine	50-58	ornithine-delta-aminotransferase	Arabidopsis thaliana	0-32
18419821-3	2008	RESULTS: We show here that ornithine-delta-aminotransferase (deltaOAT, At5g46180), the enzyme converting Orn to pyrroline-5-carboxylate (P5C), is localised in mitochondria and is essential for Arg catabolism.	Arginine	193-196	ornithine-delta-aminotransferase	Arabidopsis thaliana	27-59
18275142-3	2008	The reaction of [Ni(alpha-rac-L)](ClO4)2 with dl-Phe(-) gave a conglomerate of c-1; in which, the SS and RR enantiomers preferentially coordinate to l- and d-Phe(-) respectively to give a racemic mixture of Delta-1 and Lambda-1, and the spontaneous resolution occurs during the reaction, in which each crystal crystallizes to become enantiopure.	Arginine	47-49	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	79-82
18006876-0	2008	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	Arginine	0-3	fibrillin 1	Homo sapiens	34-53
18241826-4	2008	RESULTS: The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively.	Arginine	45-48	leptin receptor	Homo sapiens	34-38
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Arginine	105-113	Cbl proto-oncogene	Homo sapiens	199-204
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	formyl peptide receptor 2	Homo sapiens	4-9
18310453-9	2008	Intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in IA-2/IA-2beta KO than control islets.	Arginine	54-62	protein tyrosine phosphatase, receptor type, N	Mus musculus	122-126
18411439-3	2008	Arg (Abelson-related gene, Abl2) was the PTK with the highest prevalence (30% of all PTKs) and UVA led to a further induction of Arg expression reaching nine-fold mRNA baseline expression at 17 h after irradiation.	Arginine	0-3	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	27-31
18411439-3	2008	Arg (Abelson-related gene, Abl2) was the PTK with the highest prevalence (30% of all PTKs) and UVA led to a further induction of Arg expression reaching nine-fold mRNA baseline expression at 17 h after irradiation.	Arginine	0-3	protein tyrosine kinase 2 beta	Homo sapiens	41-44
18411439-3	2008	Arg (Abelson-related gene, Abl2) was the PTK with the highest prevalence (30% of all PTKs) and UVA led to a further induction of Arg expression reaching nine-fold mRNA baseline expression at 17 h after irradiation.	Arginine	129-132	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	27-31
18411439-3	2008	Arg (Abelson-related gene, Abl2) was the PTK with the highest prevalence (30% of all PTKs) and UVA led to a further induction of Arg expression reaching nine-fold mRNA baseline expression at 17 h after irradiation.	Arginine	129-132	protein tyrosine kinase 2 beta	Homo sapiens	41-44
17997171-6	2008	Carriers of the 148Arg variant (f(Arg)=0.12) of the gp130 receptor had decreased odds ratio for MI in univariate analysis (0.56, 95% CI 0.34-0.91, p=0.02).	Arginine	19-22	interleukin 6 cytokine family signal transducer	Homo sapiens	52-57
18209087-1	2008	Posttranslational modifications, such as the deimination of arginine to citrulline by peptidyl arginine deiminase (PAD4), change protein structure and function.	Arginine	60-68	peptidyl arginine deiminase 4	Homo sapiens	115-119
17420770-5	2008	We aimed to determine the effects of L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) on VEGF synthesis and free radicals in a rat model of spinal cord ischemia-reperfusion (IR) injury.	Arginine	37-47	vascular endothelial growth factor A	Rattus norvegicus	97-101
17420770-11	2008	RESULTS: L-Arginine treatment significantly increased MDA and NO, but decreased VEGF levels in spinal cord.	Arginine	9-19	vascular endothelial growth factor A	Rattus norvegicus	80-84
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	Arginine	342-350	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	24-28
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	Arginine	342-350	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	272-276
17984089-8	2008	Switch II mutations also affect binding to IQGAP1 although the effects differ between Rac1 and Cdc42; mutation of either Asp-63, Arg-68, or Leu-70 abrogate Rac1 binding, whereas no switch II mutations affect Cdc42 binding to IQGAP1.	Arginine	129-132	IQ motif containing GTPase activating protein 1	Homo sapiens	43-49
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Arginine	41-44	MLO-like protein 4	Zea mays	58-62
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Arginine	41-44	MLO-like protein 4	Zea mays	124-128
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Arginine	41-44	MLO-like protein 4	Zea mays	124-128
18408221-4	2008	Firstly, amino acid residues Lys-835 and Arg-894 of maize PEPC, which correspond to Lys-773 and Arg-832 of Escherichia coli PEPC, respectively, were replaced by Gly, since they had been shown to be involved in the binding of allosteric inhibitors, malate or aspartate, by our X-ray crystallographic analysis of E. coli PEPC.	Arginine	96-99	MLO-like protein 4	Zea mays	58-62
18569740-3	2008	We describe 1-year follow-up study of a child, aged 9.6 years, with CT1 defect, on oral supplementation with L-arginine, a precursor of creatine synthesis.	Arginine	109-119	cardiotrophin 1	Homo sapiens	68-71
18923650-2	2008	The peptidylarginine deiminases (PADs) catalyse the conversion of protein-bound arginine into citrulline (deimination), a critical reaction in the pathophysiology of multiple sclerosis, Alzheimer"s disease and rheumatoid arthritis, and in the metabolism of the major epidermal barrier protein filaggrin, a strong predisposing factor for atopic dermatitis.	Arginine	12-20	filaggrin	Homo sapiens	293-302
18082610-4	2007	We used computational and molecular approaches to predict that Trm9 enhances the translation of some transcripts overrepresented with specific arginine and glutamic acid codons.	Arginine	143-151	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase	Saccharomyces cerevisiae S288C	63-67
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase	Saccharomyces cerevisiae S288C	211-215
18032603-6	2007	The P1-P1" position for Egf1.0 has the sequence Arg-Phe, which suggested that its target proteinase is a prophenoloxidase-activating proteinase (PAP).	Arginine	48-51	G elongation factor mitochondrial 1	Homo sapiens	24-28
18025461-0	2007	The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.	Arginine	91-99	recombination activating 2	Homo sapiens	32-36
18025461-6	2007	Second, in contrast to other H3K4me3-binding PHD domains, RAG2-PHD substitutes a carboxylate that interacts with arginine 2 (R2) with a Tyr, resulting in binding to H3K4me3 that is enhanced rather than inhibited by dimethylation of R2.	Arginine	113-121	recombination activating 2	Homo sapiens	58-62
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Arginine	232-235	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Arginine	232-235	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
20641675-11	2004	A synthetic peptide (Arg-Glu-Asn-Leu-Arg-Ile-Ala-Leu-Arg-Tyr, B2702-p) corresponding to residues 75-84 of HLA-B2702 was shown to bind specifically to VCAM-1 (9).	Arginine	21-24	major histocompatibility complex, class I, B	Homo sapiens	106-111
17335829-4	2007	Here we describe a single nucleotide substitution in the coding region of exon 9 of LDLR that is an apparently silent polymorphism: CGG (Arg406) to AGG (Arg).	Arginine	137-140	low density lipoprotein receptor	Homo sapiens	84-88
17627905-7	2007	Finally, a conserved arginine residue in the "zincless finger" motif, previously identified in human NEIL1, is required for the DNA glycosylase activity of MvNei1.	Arginine	21-29	nei like DNA glycosylase 1	Homo sapiens	101-106
17717015-11	2007	Furthermore, L-arginine enhanced both nuclear factor-kB (NF-kB) and neuronal nitric oxide synthase (nNOS) immunopositivities.	Arginine	13-23	nuclear factor kappa B subunit 1	Rattus norvegicus	38-55
17717015-11	2007	Furthermore, L-arginine enhanced both nuclear factor-kB (NF-kB) and neuronal nitric oxide synthase (nNOS) immunopositivities.	Arginine	13-23	nuclear factor kappa B subunit 1	Rattus norvegicus	57-62
17614145-2	2007	It is showed that the substitution of glutamine by arginine but not by histidine at ovine PrP position 171 abolishes completely the recognition of either PrP(c) or PrP(d) by mAb 2A11, in such a way that the application of this antibody allows the unambiguous discrimination of R(171) homozygotes.	Arginine	51-59	major prion protein	Ovis aries	154-157
17614145-2	2007	It is showed that the substitution of glutamine by arginine but not by histidine at ovine PrP position 171 abolishes completely the recognition of either PrP(c) or PrP(d) by mAb 2A11, in such a way that the application of this antibody allows the unambiguous discrimination of R(171) homozygotes.	Arginine	51-59	major prion protein	Ovis aries	154-160
17869444-9	2007	Furthermore, the specific Kv channel blocker for Kv1.1 (dendrotoxin-K) or Kv1.2 (tityustoxin-Kalpha) abolished the effect of l-arginine on mIPSCs in all neurons tested.	Arginine	125-135	potassium voltage-gated channel subfamily A member 1	Homo sapiens	49-54
17928439-6	2007	Hippocampal CA1 pyramidal dendrites develop normally in arg-/- mice, reaching their mature size by postnatal day 21 (P21).	Arginine	56-59	carbonic anhydrase 1	Mus musculus	12-15
17504976-6	2007	Arginine and aminoguanidine, used as carbonyl scavengers, reversed the inhibitory effect and the formation of AGE adducts on PDGFRbeta.	Arginine	0-8	platelet derived growth factor receptor, beta polypeptide	Mus musculus	125-134
17611150-1	2007	Chlamydomonas reinhardtii arg7-8 (arg2) mutant strains carrying a hitherto undescribed mutation in their argininosuccinate lyase gene (ARG7) that leads to arginine auxotrophy have been used together with the corresponding wild-type gene as a very reliable transformation system since 1989.	Arginine	155-163	uncharacterized protein	Chlamydomonas reinhardtii	26-32
17611150-1	2007	Chlamydomonas reinhardtii arg7-8 (arg2) mutant strains carrying a hitherto undescribed mutation in their argininosuccinate lyase gene (ARG7) that leads to arginine auxotrophy have been used together with the corresponding wild-type gene as a very reliable transformation system since 1989.	Arginine	155-163	uncharacterized protein	Chlamydomonas reinhardtii	135-139
17613527-6	2007	Substitution of tyrosine 296 in A-RAF to arginine led to a constitutively active kinase.	Arginine	41-49	A-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	32-37
17566099-11	2007	Triple stimulation with ghrelin, CRH, and l-arginine potentiated the effect of combined ghrelin/CRH by 1.45-fold (P = 0.028).	Arginine	42-52	corticotropin releasing hormone	Homo sapiens	96-99
17566099-13	2007	CONCLUSIONS: The present outcomes indicate that the peptide ensemble comprising ghrelin, CRH, and SS (inferred by l-arginine infusion) can regulate ACTH and cortisol secretion in healthy adults.	Arginine	114-124	corticotropin releasing hormone	Homo sapiens	89-92
17878706-2	2007	The present in vivo study shows that the inhibitory effect of [Met(5)]enkephalin-Arg(6)-Phe(7) administered intra-third-ventricularly on the tail-flick response was increased more than 1000-fold by the intra-third-ventricular pretreatment with three peptidase inhibitors.	Arginine	81-84	proenkephalin	Rattus norvegicus	70-80
17592510-6	2007	Adhesion assays revealed that baicalein stimulated endothelial cell adhesion to fibronectin and vitronectin, effects blocked by the synthetic peptide Arg-Gly-Asp (RGD).	Arginine	150-153	fibronectin 1	Rattus norvegicus	80-91
17668007-5	2007	The linker connecting RRM1 and RRM2 contains arginine residues, which provide a binding site for the mRNA export factor TAP, and when TAP binds to this region it displaces RNA bound to RRM2.	Arginine	45-53	ribonucleotide reductase regulatory subunit M2	Homo sapiens	31-35
17544230-6	2007	Under the same experimental condition, lysine to arginine substitution of histone H3 at position 36 abolished the methyltransferase activity of Drosophila ASH1, suggesting that K36 is their specific target.	Arginine	49-57	absent, small, or homeotic discs 1	Drosophila melanogaster	155-159
17562347-9	2007	Our finding implicates functional importance of histidine in exchange of arginine at amino acid 481 of transferrin receptor 2 in iron homeostasis.	Arginine	73-81	transferrin receptor 2	Homo sapiens	103-125
17473056-7	2007	The key feature seems to be an arginine residue uniquely present at the 514-equivalent position in hERG2, where the other two isoforms possess a glycine.	Arginine	31-39	potassium voltage-gated channel subfamily H member 6	Homo sapiens	99-104
18217483-4	2007	hK14 had trypsin-like activity with a strong preference for Arg over Lys in the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Arginine	60-63	keratin 14	Homo sapiens	0-4
17606903-5	2007	The PAR4 fragment, traced entirely in the electron density maps except for five C-terminal residues, clamps Trp-60d, Tyr-60a, and the aryl-binding site of thrombin with Pro-56 and Pro-58 at the P2 and P4 positions and engages the primary specificity pocket with Arg-59.	Arginine	262-265	coagulation factor II (thrombin) receptor-like 3	Mus musculus	4-8
17550233-5	2007	PRMT1 and PRMT3 showed a preference for methylating arginine residues in the first AT-hook of HMGA1 proteins, whereas PRMT6 methylated mainly residues in the second AT-hook.	Arginine	52-60	high mobility group AT-hook 1	Homo sapiens	94-99
17513176-5	2007	Sequencing of the C1q genes revealed a novel missense mutation (Gly-Arg) in codon 217 of the B chain.	Arginine	68-71	complement C1q A chain	Homo sapiens	18-21
17114298-9	2007	PAR-2 activation also reversed the inhibition of secretion observed in both the caerulein and arginine models.	Arginine	94-102	coagulation factor II (thrombin) receptor-like 1	Mus musculus	0-5
17506542-1	2007	Following stimulation of NRK49F rat kidney fibroblast cells with epidermal growth factor, possible preemptive cross-talk between arginine methylation and serine and tyrosine phosphorylation was observed for Rho guanidine nucleotide dissociation inhibitor 1 (RhoGDI-1).	Arginine	129-137	Rho GDP dissociation inhibitor alpha	Rattus norvegicus	207-256
17506542-1	2007	Following stimulation of NRK49F rat kidney fibroblast cells with epidermal growth factor, possible preemptive cross-talk between arginine methylation and serine and tyrosine phosphorylation was observed for Rho guanidine nucleotide dissociation inhibitor 1 (RhoGDI-1).	Arginine	129-137	Rho GDP dissociation inhibitor alpha	Rattus norvegicus	258-266
17456793-2	2007	Recently, it was noted that the human peptidylarginine deiminase type IV gene (PADI4) regulates the expression of estrogen-responsive genes by modifying the methylated arginine sites in histones H3 and H4.	Arginine	46-54	peptidyl arginine deiminase 4	Homo sapiens	79-84
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Arginine	201-204	insulin like 3	Homo sapiens	63-68
17473281-10	2007	From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.	Arginine	201-204	relaxin family peptide receptor 2	Homo sapiens	69-73
17548691-5	2007	After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05).	Arginine	181-184	glutathione S-transferase pi 1	Homo sapiens	231-236
17400548-4	2007	We now report that alterations in the 0-layer Gln or Arg residues of Vam7p or Nyv1p, respectively, strongly inhibit fusion.	Arginine	53-56	Nyv1p	Saccharomyces cerevisiae S288C	78-83
17353191-4	2007	Here we mutated a conserved positively charged arginine residue (Arg(466)) in the 11(th) transmembrane helix of human OAT1.	Arginine	47-55	solute carrier family 22 member 6	Homo sapiens	118-122
17353191-4	2007	Here we mutated a conserved positively charged arginine residue (Arg(466)) in the 11(th) transmembrane helix of human OAT1.	Arginine	65-68	solute carrier family 22 member 6	Homo sapiens	118-122
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Arginine	215-218	plasminogen activator, urokinase receptor	Homo sapiens	191-195
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Arginine	331-334	plasminogen activator, urokinase receptor	Homo sapiens	191-195
17237151-3	2007	With the use of immunoblotting, flow immunocytometry, and ELISA analyses applied to a recombinant uPAR protein and to uPAR-expressing monocytic and human bronchial epithelial cells, it was shown that exposure of uPAR to soluble HAT in the range of 10-500 nM resulted in the proteolytic processing of the full-length (D1D2D3) into the truncated (D2D3) species, with cleavage occurring in the D1 to D2 linker sequence after arginine residues at position 83 and 89.	Arginine	422-430	plasminogen activator, urokinase receptor	Homo sapiens	98-102
17374638-0	2007	Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.	Arginine	51-54	fibrillin 1	Homo sapiens	17-28
17512708-2	2007	Argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL) are two ornithine cycle enzymes catalysing the last two steps in the arginine biosynthetic pathway.	Arginine	138-146	argininosuccinate synthase 1	Homo sapiens	30-33
17512708-13	2007	Both ass and asl genes were up-regulated within 3h after harvest showing that the induction mechanism is very sensitive to the harvest event and emphasizes the importance of the arginine biosynthetic pathway/ornithine cycle in post-harvest physiology.	Arginine	178-186	argininosuccinate synthase 1	Homo sapiens	5-8
17323935-7	2007	These results suggest that both Arg-200 and Lys-201 of TF interact with EGF-1 of fX to facilitate the optimal docking of the substrate into the catalytic groove of the protease in the activation complex.	Arginine	32-35	coagulation factor III, tissue factor	Homo sapiens	55-57
17323935-7	2007	These results suggest that both Arg-200 and Lys-201 of TF interact with EGF-1 of fX to facilitate the optimal docking of the substrate into the catalytic groove of the protease in the activation complex.	Arginine	32-35	G elongation factor mitochondrial 1	Homo sapiens	72-77
17250643-10	2007	Moreover, the effects of pretreatment with AM251 (2 ng/rat), L-arginine (0.01 microg/rat) and L-NAME (1 ng/rat) on the response induced by intra-CA1 administration of WIN55212-2 were also assessed.	Arginine	61-71	carbonic anhydrase 1	Rattus norvegicus	145-148
17327334-4	2007	From this test, the acute insulin response (AIR) to arginine during the three glucose levels (AIR1, AIR2, and AIR3) were estimated.	Arginine	52-60	zinc finger CCHC-type containing 7	Homo sapiens	94-98
17164794-6	2007	Isoform SAHH-3 is based on a new polymorphism in exon 3 (377 G&gt;A), leading to the conversion of glycine to arginine at amino-acid position 123.	Arginine	110-118	adenosylhomocysteinase	Homo sapiens	8-12
17096330-2	2007	The efficacy of its antitumor activity largely depends on the level of intracellular ASS, which enables tumor cells to recycle citrulline to arginine.	Arginine	141-149	argininosuccinate synthase 1	Homo sapiens	85-88
17096330-3	2007	Thus, we examined the expression levels of ASS in various cancer cells and found that it is low in renal cell carcinoma (RCC) cells, rendering the cells highly sensitive to arginine deprivation by ADI treatment.	Arginine	173-181	argininosuccinate synthase 1	Homo sapiens	43-46
16979358-5	2007	Although differences exist in AAP sequence, there were three absolutely conserved amino acid residues in the predicted peptide, including an aspartic acid crucial for arginine-dependent regulation of arg-2 and CPA1.	Arginine	167-175	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	210-214
17287563-4	2007	Arginine decarboxylase, arginase and nitric oxide synthase are the key enzymes in L-arginine catabolism, in which polyamines are formed through ADC or arginase-ODC pathway while nitric oxide is formed through the NOS pathway.	Arginine	82-92	antizyme inhibitor 2	Homo sapiens	0-22
17910280-6	2007	The A (Arg) allele frequency was 0.08 among the population and its presence was significantly associated with increase of leptin level (AA/TA, 30.5+/-24.8 ng/mL; TT, 22.6+/-20.9 ng/mL; P=0.014) but there was no significant association with increased BMI (AA/TA, 27+/-5.6 kg/m2; TT, 25.4+/-5.5 kg/m2; P=0.072).	Arginine	7-10	leptin	Homo sapiens	122-128
17166179-3	2007	CNBP is mainly conformed by seven retroviral Cys-Cys-His-Cys zinc-knuckles and a glycine/arginine rich region box.	Arginine	89-97	CCHC-type zinc finger, nucleic acid binding protein a	Danio rerio	0-4
17341467-3	2007	Here we describe a short amphipathic peptide, Pep-3, that combines a tryptophan/phenylalanine domain with a lysine/arginine-rich hydrophilic motif.	Arginine	115-123	VPS18 core subunit of CORVET and HOPS complexes	Homo sapiens	46-51
17189218-4	2006	The GGCX 8016G&gt;A change leads to the substitution of Gin for Arg at amino acid residue 325 (Arg 325 Gln).	Arginine	64-67	gamma-glutamyl carboxylase	Homo sapiens	4-8
17064349-7	2006	Moreover, deletion of the N-terminal 9 amino acids and substitution of both Arg-8 and Arg-9 of RGS8 with Ala resulted in reduced binding to M1i3.	Arginine	76-79	regulator of G protein signaling 8	Homo sapiens	95-99
17064349-7	2006	Moreover, deletion of the N-terminal 9 amino acids and substitution of both Arg-8 and Arg-9 of RGS8 with Ala resulted in reduced binding to M1i3.	Arginine	86-89	regulator of G protein signaling 8	Homo sapiens	95-99
17010310-2	2006	Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three RNA recognition motifs, and an Arg/Gly-rich region.	Arginine	182-185	apolipoprotein B mRNA editing enzyme catalytic subunit 1	Homo sapiens	0-7
17064696-5	2006	The efficacy of cleavage of SK1 at arginine 199, however, was not affected.	Arginine	35-43	sphingosine kinase 1	Homo sapiens	28-31
17028574-5	2006	Moreover, we show the functional importance of acetylation in live animals by using a mutant of MyoD in which lysines 99 and 102 were replaced by arginines (R).	Arginine	146-155	myogenic differentiation 1	Mus musculus	96-100
17046546-7	2006	The frequency of IRS-1 gene polymorphism was significantly higher in women with GDM than in women with a normal glucose tolerance (NGT) (P = .039), and there was a significant trend (P = .032) in the increasing frequency of mutant allele Arg from NGT &gt; gestational impaired glucose tolerance &gt; GDM.	Arginine	238-241	insulin receptor substrate 1	Homo sapiens	17-22
17046546-9	2006	The X-Arg genotype of IRS-1 was significantly associated with a positive family history of diabetes in NGT (P = .006) and neared significance in GDM (P = .057).	Arginine	6-9	insulin receptor substrate 1	Homo sapiens	22-27
17189908-5	2006	mK5 had trypsin-like activity for Arg at the P1 position, and its activity was inhibited by typical serine protease inhibitors.	Arginine	34-37	keratin 5	Mus musculus	0-3
17024186-3	2006	We identify an arginine/serine-rich region of U2AF 65 that mediates an interaction with an RS-like alternating charge domain of the 59 kDa subunit of the human cleavage factor I (CF I(m)), an essential 3" processing factor that functions at an early step in the recognition of the 3" end processing signal.	Arginine	15-23	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	46-53
16721783-10	2006	Our findings suggest that the codon 52 D MBL2 variant causing a cysteine &gt; arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk.	Arginine	78-86	mannose binding lectin 2	Homo sapiens	41-45
17015720-6	2006	Most KIR2DL2/3 alleles possess an arginine at position 41 (R41), and we predicted through molecular modeling and demonstrated by mutagenesis that R41 most likely interacts with the nearby residues Y77 and D47.	Arginine	34-42	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2	Homo sapiens	5-14
17002273-1	2006	Protein arginine deiminase 4 (PAD4) is a transcriptional coregulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	30-34
17023768-4	2006	Agmatine is a metabolite of arginine via arginine decarboxylase (ADC), highly expressed in the kidney, and unique in its capacity to suppress intracellular polyamine levels required for proliferation.	Arginine	28-36	antizyme inhibitor 2	Homo sapiens	41-63
17023768-4	2006	Agmatine is a metabolite of arginine via arginine decarboxylase (ADC), highly expressed in the kidney, and unique in its capacity to suppress intracellular polyamine levels required for proliferation.	Arginine	28-36	antizyme inhibitor 2	Homo sapiens	65-68
16906756-8	2006	Given the location of Arg(B108), Arg (B109), and Tyr(B175) in the gC1q crystal structure, it is likely that C1q interacts with IgM via the top of the gC1q domain.	Arginine	22-25	complement C1q A chain	Homo sapiens	67-70
17037282-12	2006	Because the standard input function in the ARG method was obtained using IMPA, the standard input function obtained for IMPB should be used when CBF is calculated by the ARG method with IMPB.	Arginine	43-46	inositol monophosphatase 1	Homo sapiens	73-77
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	43-53	insulin-like growth factor 1	Rattus norvegicus	75-109
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	43-53	insulin-like growth factor binding protein 3	Rattus norvegicus	119-140
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	43-53	insulin-like growth factor binding protein 3	Rattus norvegicus	141-147
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	43-53	insulin-like growth factor 1	Rattus norvegicus	111-116
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	217-227	insulin-like growth factor binding protein 3	Rattus norvegicus	141-147
16690613-11	2006	Our results suggest that proteolysis of the alpha subunit activates ENaC by disassociating an inhibitory domain (alphaAsp-206-Arg-231) from its effector site within the channel complex.	Arginine	126-129	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	68-72
16820065-1	2006	BACKGROUND: Recent studies have suggested that the Arg allele of beta3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral density (BMD) and fracture risk.	Arginine	51-54	adrenoceptor beta 3	Homo sapiens	65-90
16820065-1	2006	BACKGROUND: Recent studies have suggested that the Arg allele of beta3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral density (BMD) and fracture risk.	Arginine	51-54	adrenoceptor beta 3	Homo sapiens	92-97
16802253-1	2006	The purpose of the study was to determine the potential beneficial effect of six weeks oral L-arginine supplementation (LAS) on endurance exercise, an important determinant of daily-life activity in patients with chronic stable heart failure (CHF).	Arginine	92-102	lipoic acid synthetase	Homo sapiens	120-123
16515785-7	2006	Furthermore, deletion of a subdomain (KRKHPRRAQ) in the peptide or amino acid substitution of lysine and arginine residues in the subdomain resulted in the loss of Nop25 nucleolar localization.	Arginine	105-113	nucleolar protein 12	Homo sapiens	164-169
16515785-8	2006	These results suggest that the lysine and arginine residue-enriched peptide is the most prominent nucleolar targeting sequence of Nop25 and that the long stretch of basic residues might play an important role in the nucleolar localization of Nop25.	Arginine	42-50	nucleolar protein 12	Homo sapiens	130-135
16765689-7	2006	CONCLUSIONS: A recurrent mutation of FBN1 gene resulted in an arginine-to-cysteine residue (p.R62C), is responsible for the patients with isolated ectopia lentis in a Chinese family.	Arginine	62-70	fibrillin 1	Homo sapiens	37-41
16703566-1	2006	In murine macrophages, as a result of arginine catabolism during activation, citruline is produced under the effect of IFN-gamma and LPS, and ornithine and polyamines by IL-4 and IL-10.	Arginine	38-46	interleukin 4	Mus musculus	170-174
16703566-7	2006	The increase in arginine transport during activation, but not proliferation, was mediated by the SLC7A2/Cat2 gene.	Arginine	16-24	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	97-103
16738308-0	2006	Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function.	Arginine	8-16	Rous sarcoma oncogene	Mus musculus	0-3
16738308-0	2006	Src SH2 arginine 175 is required for cell motility: specific focal adhesion kinase targeting and focal adhesion assembly function.	Arginine	8-16	PTK2 protein tyrosine kinase 2	Mus musculus	61-82
16670331-3	2006	MD-2 directly interacts with LPS, and the region from Phe(119) to Lys(132) (Arg(132) in mice) has been shown to be important for interaction between LPS and TLR4/MD-2.	Arginine	76-79	lymphocyte antigen 96	Mus musculus	162-166
16574906-8	2006	This occurred via an Arg-Gly-Asp (RGD) peptide-independent pathway through activation of G(i/o) proteins, phosphatidylinositol 3-kinase, Akt, and eNOS.	Arginine	21-24	nitric oxide synthase 3, endothelial cell	Mus musculus	146-150
16371438-12	2006	Nonetheless, the increase in CAT1 activity only partially compensated the lack of CAT2 and L-arginine metabolism was hardly stimulated.	Arginine	91-101	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	29-33
16426232-10	2006	Although we detected Rmt1-dependent arginine methylation in vivo in purified yeast histones H2A, H2B, H3 and H4, we found no evidence for Hsl7-dependent methylation of endogenous yeast histones.	Arginine	36-44	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	21-25
16604067-2	2006	The abnormal behavior of unc-17(e245) mutants, which have a glycine-to-arginine substitution in a transmembrane domain, is markedly improved by a mutant synaptobrevin with an isoleucine-to-aspartate substitution in its transmembrane domain.	Arginine	71-79	Vesicular acetylcholine transporter unc-17	Caenorhabditis elegans	25-31
16567635-3	2006	However, it has recently been shown that human peptidylarginine deiminase 4 (PAD4), a Ca(2+)-dependent enzyme previously known to convert arginine residues to citrulline in histones, can also convert monomethylated arginine residues to citrulline both in vivo and in vitro.	Arginine	55-63	peptidyl arginine deiminase 4	Homo sapiens	77-81
16567635-3	2006	However, it has recently been shown that human peptidylarginine deiminase 4 (PAD4), a Ca(2+)-dependent enzyme previously known to convert arginine residues to citrulline in histones, can also convert monomethylated arginine residues to citrulline both in vivo and in vitro.	Arginine	138-146	peptidyl arginine deiminase 4	Homo sapiens	47-75
16567635-3	2006	However, it has recently been shown that human peptidylarginine deiminase 4 (PAD4), a Ca(2+)-dependent enzyme previously known to convert arginine residues to citrulline in histones, can also convert monomethylated arginine residues to citrulline both in vivo and in vitro.	Arginine	138-146	peptidyl arginine deiminase 4	Homo sapiens	77-81
16567635-5	2006	Here we present the crystal structures of a Ca(2+)-bound PAD4 mutant in complex with three histone N-terminal peptides, each consisting of 10 amino acid residues that include one target arginine residue for the enzyme (H3/Arg-8, H3/Arg-17, and H4/Arg-3).	Arginine	186-194	peptidyl arginine deiminase 4	Homo sapiens	57-61
16567635-5	2006	Here we present the crystal structures of a Ca(2+)-bound PAD4 mutant in complex with three histone N-terminal peptides, each consisting of 10 amino acid residues that include one target arginine residue for the enzyme (H3/Arg-8, H3/Arg-17, and H4/Arg-3).	Arginine	222-225	peptidyl arginine deiminase 4	Homo sapiens	57-61
16567635-5	2006	Here we present the crystal structures of a Ca(2+)-bound PAD4 mutant in complex with three histone N-terminal peptides, each consisting of 10 amino acid residues that include one target arginine residue for the enzyme (H3/Arg-8, H3/Arg-17, and H4/Arg-3).	Arginine	232-235	peptidyl arginine deiminase 4	Homo sapiens	57-61
16567635-5	2006	Here we present the crystal structures of a Ca(2+)-bound PAD4 mutant in complex with three histone N-terminal peptides, each consisting of 10 amino acid residues that include one target arginine residue for the enzyme (H3/Arg-8, H3/Arg-17, and H4/Arg-3).	Arginine	232-235	peptidyl arginine deiminase 4	Homo sapiens	57-61
16567635-10	2006	These observations provide structural insights into target protein recognition by histone modification enzymes and illustrate how PAD4 can target multiple arginine sites in the histone N-terminal tails.	Arginine	155-163	peptidyl arginine deiminase 4	Homo sapiens	130-134
16491103-3	2006	Agonists for GPRC6A are basic amino acids, particularly the analogues and derivatives of L-arginine and L-ornithine.	Arginine	89-99	G protein-coupled receptor class C group 6 member A	Homo sapiens	13-19
16384863-5	2006	In this study we found that AGRP is processed intracellularly after Arg(79)-Glu(80)-Pro(81)-Arg(82).	Arginine	68-71	agouti related neuropeptide	Rattus norvegicus	28-32
16384863-5	2006	In this study we found that AGRP is processed intracellularly after Arg(79)-Glu(80)-Pro(81)-Arg(82).	Arginine	92-95	agouti related neuropeptide	Rattus norvegicus	28-32
16581807-4	2006	In addition, two pseudouridine synthases, PUS3 and PUS4, are important for growth in strains carrying a mutation in tRNA(Arg)(CCG) and are essential when La is deleted in these strains.	Arginine	121-124	pseudouridine synthase DEG1	Saccharomyces cerevisiae S288C	42-46
16581807-4	2006	In addition, two pseudouridine synthases, PUS3 and PUS4, are important for growth in strains carrying a mutation in tRNA(Arg)(CCG) and are essential when La is deleted in these strains.	Arginine	121-124	pseudouridine synthase PUS4	Saccharomyces cerevisiae S288C	51-55
16581807-5	2006	Depletion of Pus3p results in accumulation of the aminoacylated mutant tRNA(Arg)(CCG) in nuclei, while depletion of Pus4p results in decreased stability of the mutant tRNA.	Arginine	76-79	pseudouridine synthase DEG1	Saccharomyces cerevisiae S288C	13-18
17177802-2	2006	We substituted the arginine 304 present in the wild-type H. verticillata phytoene desaturase (PDS) with all 19 other natural amino acids and tested PDS against fluridone.	Arginine	19-27	phytoene desaturase 3	Arabidopsis thaliana	94-97
16480258-3	2006	The high degree of selectivity was attributed to a difference in the amino acid sequence adjacent to a key arginine-ligand interaction allowing somewhat larger ligands to be tolerated by GPR109b.	Arginine	107-115	hydroxycarboxylic acid receptor 3	Homo sapiens	187-194
16293633-4	2006	Arginine methylation was recently demonstrated to occur on HMGA1a protein, and it correlates with the apoptotic process and neoplastic progression.	Arginine	0-8	high mobility group AT-hook 1	Homo sapiens	59-65
16470308-1	2006	Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH.	Arginine	163-171	carboxypeptidase M	Homo sapiens	0-18
16470308-1	2006	Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH.	Arginine	163-171	carboxypeptidase M	Homo sapiens	20-23
16445852-1	2006	After our initial report of a mammalian gene for arginine decarboxylase, an enzyme for the synthesis of agmatine from arginine, we have determined the regional expression of ADC in rat.	Arginine	49-57	antizyme inhibitor 2	Homo sapiens	174-177
16249370-9	2006	Amino acid substitutions in the apoE peptide sequence suggest that the arginines are critical for peptide blockade of the alpha7 nAChR.	Arginine	71-80	apolipoprotein E L homeolog	Xenopus laevis	32-36
16329147-14	2006	In the small intestine, Nos2 prevents the arginine-induced decrease in tumor number and size, which is associated with NOS3 expression and increased apoptosis.	Arginine	42-50	nitric oxide synthase 3, endothelial cell	Mus musculus	119-123
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Arginine	212-220	ADP-ribosylserine hydrolase	Homo sapiens	96-100
16482626-11	2006	RESULTS: L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio (pw/bw), the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values.	Arginine	9-14	myeloperoxidase	Rattus norvegicus	222-237
16356828-3	2006	MCF-7 and A549 cells have notable different sensitivity to recombinant ADI (rADI) and express diverse argininosuccinate synthase (AS) activity, which regenerates arginine.	Arginine	162-170	argininosuccinate synthase 1	Homo sapiens	102-128
16356828-3	2006	MCF-7 and A549 cells have notable different sensitivity to recombinant ADI (rADI) and express diverse argininosuccinate synthase (AS) activity, which regenerates arginine.	Arginine	162-170	argininosuccinate synthase 1	Homo sapiens	130-132
17135210-5	2006	Surprisingly, Tra, Tra2 and 9G8 are much stronger splicing activators than other SR protein family members and their activation potential is significantly higher than expected from their serine/arginine content.	Arginine	194-202	transformer	Drosophila melanogaster	14-17
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	27-30	pleckstrin	Homo sapiens	84-87
16216872-10	2005	Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP.	Arginine	40-43	pleckstrin	Homo sapiens	84-87
16437653-9	2005	The splenocyte IL-2 mRNA expression in the Arg-supplemented groups was significantly higher than that in group 1.	Arginine	43-46	interleukin 2	Rattus norvegicus	15-19
16715838-1	2005	The substitution of tryptophan (Trp) by arginine (Arg) at position 64 in the beta3-adrenoceptor (beta3-AR) gene has been associated with obesity, diabetes mellitus, and coronary artery disease (CAD).	Arginine	40-48	adrenoceptor beta 3	Homo sapiens	77-95
16715838-1	2005	The substitution of tryptophan (Trp) by arginine (Arg) at position 64 in the beta3-adrenoceptor (beta3-AR) gene has been associated with obesity, diabetes mellitus, and coronary artery disease (CAD).	Arginine	40-48	adrenoceptor beta 3	Homo sapiens	97-105
16715838-1	2005	The substitution of tryptophan (Trp) by arginine (Arg) at position 64 in the beta3-adrenoceptor (beta3-AR) gene has been associated with obesity, diabetes mellitus, and coronary artery disease (CAD).	Arginine	50-53	adrenoceptor beta 3	Homo sapiens	77-95
16715838-1	2005	The substitution of tryptophan (Trp) by arginine (Arg) at position 64 in the beta3-adrenoceptor (beta3-AR) gene has been associated with obesity, diabetes mellitus, and coronary artery disease (CAD).	Arginine	50-53	adrenoceptor beta 3	Homo sapiens	97-105
15979761-0	2005	Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide.	Arginine	129-132	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-41
15979761-0	2005	Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide.	Arginine	133-136	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-41
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	121-124	proprotein convertase subtilisin/kexin type 1	Homo sapiens	21-50
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	121-124	proprotein convertase subtilisin/kexin type 1	Homo sapiens	52-55
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	121-124	proprotein convertase subtilisin/kexin type 2	Homo sapiens	60-63
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	21-50
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	52-55
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 2	Homo sapiens	60-63
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	21-50
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	52-55
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 2	Homo sapiens	60-63
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	21-50
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	52-55
15979761-1	2005	Purified recombinant prohormone convertase 1 and 2 (PC1 and PC2) cleave a peptide containing cholecystokinin (CCK) 8 Gly Arg Arg and the carboxyl-terminal peptide liberating CCK 8 Gly Arg Arg.	Arginine	125-128	proprotein convertase subtilisin/kexin type 2	Homo sapiens	60-63
16285926-2	2005	Negative translational regulation of CPA1 occurs when the nascent AAP responds to arginine (Arg) by stalling ribosomes at the uORF termination codon.	Arginine	82-90	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	37-41
16285926-2	2005	Negative translational regulation of CPA1 occurs when the nascent AAP responds to arginine (Arg) by stalling ribosomes at the uORF termination codon.	Arginine	92-95	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	37-41
16285926-5	2005	Arg addition to media rapidly destabilized the CPA1 transcript in wild-type but not upf1delta cells.	Arginine	0-3	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	47-51
16278448-1	2005	The yeast Mcm1 protein is a member of the MADS box family of transcription factors that interacts with several cofactors to differentially regulate genes involved in cell-type determination, mating, cell cycle control and arginine metabolism.	Arginine	222-230	transcription factor MCM1	Saccharomyces cerevisiae S288C	10-14
16229464-1	2005	The enzymes dimethylargininase [dimethylarginine dimethylaminohydrolase (DDAH); EC 3.5.3.18] and peptidylarginine deiminase (PAD; EC 3.5.3.15) catalyze hydrolysis of substituted arginines.	Arginine	178-187	peptidyl arginine deiminase 4	Homo sapiens	97-123
16229464-1	2005	The enzymes dimethylargininase [dimethylarginine dimethylaminohydrolase (DDAH); EC 3.5.3.18] and peptidylarginine deiminase (PAD; EC 3.5.3.15) catalyze hydrolysis of substituted arginines.	Arginine	178-187	peptidyl arginine deiminase 4	Homo sapiens	125-128
16220201-7	2005	(4) SNP and L-Arg induced a down-regulation of Bcl-2 and an up-regulation of Bax proteins in normal AMs, but did not induce the same change pattern in BLM AMs.	Arginine	12-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	77-80
16220201-8	2005	(5) The Bax in BLM AMs was down-regulated by L-Arg.	Arginine	45-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	8-11
16211657-6	2005	EMC-Arg-Arg-Ser-Ser-Tyr-Tyr-Ser-Gly-DOXO showed no in vivo activity in the PSA-negative PC 3 model, but good activity in the CWR22 PSA-positive model that was comparable to Doxorubicin.	Arginine	4-7	kallikrein related peptidase 3	Homo sapiens	131-134
16186386-0	2005	BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.	Arginine	60-68	neuronal differentiation 1	Homo sapiens	0-12
16177304-6	2005	The basic residues in granulysin are arginine, while those in NK-lysin and chicken NK-lysin are a mixture of arginine and lysine.	Arginine	37-45	granulysin	Gallus gallus	22-32
16177304-6	2005	The basic residues in granulysin are arginine, while those in NK-lysin and chicken NK-lysin are a mixture of arginine and lysine.	Arginine	109-117	granulysin	Gallus gallus	62-70
16177304-6	2005	The basic residues in granulysin are arginine, while those in NK-lysin and chicken NK-lysin are a mixture of arginine and lysine.	Arginine	109-117	granulysin	Gallus gallus	83-91
16177304-9	2005	In granulysin, the arginines in the loop structure are not crucial for antimycobacterial activity but are important for cytotoxicity.	Arginine	19-28	granulysin	Gallus gallus	3-13
16205319-5	2005	WBH induced apoptosis, as indicated by DNA fragmentation, and increased levels of p53 and caspase-3 activity, which were significantly reduced by the administration of L-arg.	Arginine	168-173	transformation related protein 53, pseudogene	Mus musculus	82-85
16006651-4	2005	Our mass spectrometric data showed that of 24 lysines and 18 arginines readily susceptible to small chemical reagent modification in native RPA, the three residues Lys-343, Arg-335, and Arg-382, located in DNA binding domain B (DBD-B) of RPA70, were significantly shielded in the hyperphosphorylated protein.	Arginine	61-70	replication protein A1	Homo sapiens	238-243
16051612-7	2005	A glutathione S-transferase fusion protein of PRMT8 has type I PRMT activity, catalyzing the formation of omega-NG-monomethylated and asymmetrically omega-NG,NG-dimethylated arginine residues on a recombinant glycine- and arginine-rich substrate.	Arginine	174-182	protein arginine methyltransferase 8	Homo sapiens	46-51
16027151-10	2005	Arg substitution of three unique acidic amino acids on the surface of FN1 eliminated polysialylation not only of a minimal Ig5-FN1 substrate but also of full-length NCAM.	Arginine	0-3	neural cell adhesion molecule 1	Homo sapiens	165-169
15982908-4	2005	MFG-E8 has two domains: an Arg-Gly-Asp sequence that binds integrins alphavbeta3 and alphavbeta5 (expressed by human DCs and macrophages) and a phosphatidyl-serine (PS) binding sequence through which it associates to PS-containing membranes (among which exosomes).	Arginine	27-30	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
16140986-3	2005	Here, we performed a microarray analysis using Mef2c-null mouse embryos and identified a novel MEF2-regulated gene encoding a muscle-specific protein kinase, Srpk3, belonging to the serine arginine protein kinase (SRPK) family, which phosphorylates serine/arginine repeat-containing proteins.	Arginine	189-197	serine/arginine-rich protein specific kinase 3	Mus musculus	158-163
15937148-7	2005	Pre-exposure of SG neurons to the ORL1 receptor blocker, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101), significantly decreased the Noc-mediated Ca(2+) current inhibition.	Arginine	66-69	prepronociceptin	Rattus norvegicus	133-136
15890773-0	2005	Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1 activation.	Arginine	0-8	melanin-concentrating hormone receptor 1	Rattus norvegicus	83-123
15890773-4	2005	Here we reveal that an Arg residue in intracellular loop 2 of MCH1R plays a critical role in receptor function.	Arginine	23-26	melanin-concentrating hormone receptor 1	Rattus norvegicus	62-67
15890773-9	2005	In addition, substitution at positions corresponding to Arg155 in human MCH receptor 2 and rat somatostatin receptor 2 also markedly abolished their ligand-induced signaling capacities, indicating that this Arg is a recognition determinant in several G protein-coupled receptors.	Arginine	56-59	melanin concentrating hormone receptor 2	Homo sapiens	72-86
16041585-3	2005	The transmembrane regions of LILRC1 and LILRC2 contain an arginine residue, a common feature in receptors that associate with activating adaptor proteins.	Arginine	58-66	leukocyte immunoglobulin like receptor A5	Rattus norvegicus	29-35
16055705-2	2005	We show that a subset of serine/arginine (SR)-rich proteins activate a cryptic 3" splice site in a sense Alu repeat located in intron 4 of the human LST1 gene.	Arginine	32-40	leukocyte specific transcript 1	Homo sapiens	149-153
16055721-3	2005	HANP1/H1T2 contains an arginine-serine-rich domain and an ATP/GTP binding site, and it binds to DNA, ATP, and protamine.	Arginine	23-31	H1.7 linker histone	Mus musculus	0-5
16055721-3	2005	HANP1/H1T2 contains an arginine-serine-rich domain and an ATP/GTP binding site, and it binds to DNA, ATP, and protamine.	Arginine	23-31	H1.7 linker histone	Mus musculus	6-10
15979587-3	2005	The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gln) (LPXRFamide).	Arginine	134-137	neuropeptide VF precursor	Gallus gallus	4-8
15979587-3	2005	The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gln) (LPXRFamide).	Arginine	134-137	neuropeptide VF precursor	Gallus gallus	31-35
15979587-3	2005	The GnIH precursor encodes one GnIH and its related peptides (GnIH-RP-1 and -RP-2) that shared the same C-terminal motif, Leu-Pro-Xaa-Arg-Phe-NH2 (Xaa = Leu or Gln) (LPXRFamide).	Arginine	134-137	retinitis pigmentosa 2 (X-linked recessive)	Gallus gallus	62-81
15965529-5	2005	The performance of the system was demonstrated in the separation and determination of FITC-labeled arginine and phenylalanine with LIF detection, by continuously introducing a train of different samples.	Arginine	99-107	LIF interleukin 6 family cytokine	Homo sapiens	131-134
15976236-11	2005	Furthermore, this catecholamine-enhanced L-arginine transport might involve CAT-1 and CAT-2A but not CAT-2 or CAT-2B.	Arginine	41-51	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	76-81
16014854-8	2005	However, the presence of the triple mutant dhfr (Ile-51/Arg-59/Asn-108) with the dhps Gly-437 genotype in all recurring infections, suggests the importance of codon 59 and 437 alleles in susceptibility to TRM/SMX.	Arginine	56-59	dihydrofolate reductase	Homo sapiens	43-47
15970667-6	2005	We also demonstrate that PRMT1 is a component of PML nuclear bodies where it colocalizes with MRE11.Using cellular fractionation, we demonstrate that methylated MRE11 is predominantly associated with nuclear structures and that MRE11 methylated arginines were required for this association.	Arginine	245-254	PML nuclear body scaffold	Homo sapiens	49-52
16038412-3	2005	Here, we studied the effect of this Arg mutation on the structure and function of Hsp27.	Arginine	36-39	heat shock protein family B (small) member 1	Homo sapiens	82-87
15964796-5	2005	To investigate the physiological functional outcome of these C-terminal modifications in regulating p53 stability and activity, we introduced missense mutations (lysine to arginine) at the six lysine residues (K6R) into the endogenous p53 gene in mouse embryonic stem (ES) cells.	Arginine	172-180	transformation related protein 53, pseudogene	Mus musculus	235-238
15922518-2	2005	Changes in levels of Th2 cytokines such as interleukin-4 (IL-4) can play important roles in these conditions via effects on arginine metabolism.	Arginine	124-132	heart and neural crest derivatives expressed 2	Mus musculus	21-24
15922518-2	2005	Changes in levels of Th2 cytokines such as interleukin-4 (IL-4) can play important roles in these conditions via effects on arginine metabolism.	Arginine	124-132	interleukin 4	Mus musculus	43-56
15922518-2	2005	Changes in levels of Th2 cytokines such as interleukin-4 (IL-4) can play important roles in these conditions via effects on arginine metabolism.	Arginine	124-132	interleukin 4	Mus musculus	58-62
15922518-3	2005	IL-4 alters macrophage arginine metabolism by inducing arginase I expression and inhibiting nitric oxide production.	Arginine	23-31	interleukin 4	Mus musculus	0-4
15656789-1	2005	An important but unresolved question is whether mammalian mitochondria metabolize arginine to agmatine by the ADC (arginine decarboxylase) reaction.	Arginine	82-90	antizyme inhibitor 2	Homo sapiens	115-137
15656789-2	2005	15N-labelled arginine was used as a precursor to address this question and to determine the flux through the ADC reaction in isolated mitochondria obtained from rat liver.	Arginine	13-21	antizyme inhibitor 2	Homo sapiens	109-112
15886116-6	2005	Recent evidence suggests that Vav1 might also function in the nucleus, where it undergoes arginine methylation.	Arginine	90-98	vav 1 oncogene	Mus musculus	30-34
15907489-5	2005	Mutation of the lysine (K)-378 to arginine (R) (K378R) abolished the interaction with TbetaR-I, phosphorylation, transcriptional activation by an active TbetaR-I.	Arginine	34-42	transforming growth factor beta receptor 1	Homo sapiens	86-94
15907489-5	2005	Mutation of the lysine (K)-378 to arginine (R) (K378R) abolished the interaction with TbetaR-I, phosphorylation, transcriptional activation by an active TbetaR-I.	Arginine	34-42	transforming growth factor beta receptor 1	Homo sapiens	153-161
15661860-3	2005	E2 also significantly increased the L-arginine-evoked GnRH secretion.	Arginine	36-46	gonadotropin releasing hormone 1	Rattus norvegicus	54-58
15661860-6	2005	The use of glutamate receptor agonists and antagonists indicated that E2 effects on GnRH secretion evoked by both glutamate and L-arginine involved the 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid/kainate receptors.	Arginine	128-138	gonadotropin releasing hormone 1	Rattus norvegicus	84-88
15713679-5	2005	After producing and purifying recombinant hK5 in yeast, we determined the k(cat)/K(m) ratio of the fluorogenic substrates Gly-Pro-Arg-AMC and Gly-Pro-Lys-AMC, and showed that it has trypsin-like activity with strong preference for Arg over Lys in the P1 position.	Arginine	130-133	keratin 5	Homo sapiens	42-45
15591590-7	2005	Furthermore, we demonstrate that both HMGA1 isoforms are di-methylated on arginine and lysine residues.	Arginine	74-82	high mobility group AT-hook 1	Homo sapiens	38-43
15731352-4	2005	Here, we report that CARM1 also methylates Arg-2142 within the C-terminal GRIP1 binding domain (GBD) of p300.	Arginine	43-46	glutamate receptor interacting protein 1	Homo sapiens	74-79
15731352-5	2005	In the GBD, both Arg-2088 and Arg-2142 are important for binding GRIP1.	Arginine	17-20	glutamate receptor interacting protein 1	Homo sapiens	65-70
15731352-5	2005	In the GBD, both Arg-2088 and Arg-2142 are important for binding GRIP1.	Arginine	30-33	glutamate receptor interacting protein 1	Homo sapiens	65-70
15731352-6	2005	Methylation of Arg-2142 inhibits the bimolecular interaction of GRIP1 to p300 in vitro and in vivo.	Arginine	15-18	glutamate receptor interacting protein 1	Homo sapiens	64-69
15509659-9	2005	We conclude that the two arginine residues (R333R334) in the COOH terminus of the human P2Y(1) receptor are essential for G(q) coupling.	Arginine	25-33	purinergic receptor P2Y1	Homo sapiens	88-103
15714563-4	2005	Recently, a novel mechanism in which peptidylarginine deiminase (PAD4) converts histone H3 and H4 methyl arginine residues into citrulline was proposed to regulate estrogen-responsive gene transcription.1,2 These data, the first to provide a mechanistic basis for the dynamic changes observed in a subset of protein arginine methylated substrates,3 lead to a host of questions concerning the generality of this mechanism for non-histone targets of the protein arginine methyltransferases (PRMTs).	Arginine	45-53	peptidyl arginine deiminase 4	Homo sapiens	65-69
15714563-4	2005	Recently, a novel mechanism in which peptidylarginine deiminase (PAD4) converts histone H3 and H4 methyl arginine residues into citrulline was proposed to regulate estrogen-responsive gene transcription.1,2 These data, the first to provide a mechanistic basis for the dynamic changes observed in a subset of protein arginine methylated substrates,3 lead to a host of questions concerning the generality of this mechanism for non-histone targets of the protein arginine methyltransferases (PRMTs).	Arginine	105-113	peptidyl arginine deiminase 4	Homo sapiens	65-69
15843175-8	2005	We show that hK14 has dual activity, trypsin- and chymotrypsin-like, with a preference for cleavage after arginine residues.	Arginine	106-114	keratin 14	Homo sapiens	13-17
15709773-6	2005	Trypsin treatment of native C1q led to proteolysis of the B chain only, at a single cleavage site (Arg(109)) located in the globular region.	Arginine	99-102	complement C1q A chain	Homo sapiens	28-31
15684035-4	2005	Using recombinant proteins, we found uPAR directly binds alpha5beta1 and rather than blocking, renders fibronectin (Fn) binding by alpha5beta1 Arg-Gly-Asp (RGD) resistant.	Arginine	143-146	plasminogen activator, urokinase receptor	Homo sapiens	37-41
15546877-5	2005	Replacement of the conserved lysine residue within the Walker A motif with alanine, glutamate, or arginine results in the same DNA damage sensitivity and homologous recombination defect as the rad50 deletion mutation.	Arginine	98-106	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	193-198
15561099-8	2005	Both CAPON and utrophin protein levels increased in dystrophic quadriceps muscle after treatment with the steroid deflazacort plus L-arginine, known to reduce the dystrophic phenotype.	Arginine	131-141	nitric oxide synthase 1 adaptor protein	Homo sapiens	5-10
15561099-9	2005	The identification of CAPON transcripts and protein in mammalian muscle and responses to L-arginine suggest CAPON may have a functional role in stabilizing neuronal NOS in skeletal muscle in the cytoskeletal complex associated with dystrophin/utrophin, with possible applications to therapy for human muscular dystrophy.	Arginine	89-99	nitric oxide synthase 1 adaptor protein	Homo sapiens	108-113
15561099-9	2005	The identification of CAPON transcripts and protein in mammalian muscle and responses to L-arginine suggest CAPON may have a functional role in stabilizing neuronal NOS in skeletal muscle in the cytoskeletal complex associated with dystrophin/utrophin, with possible applications to therapy for human muscular dystrophy.	Arginine	89-99	dystrophin	Homo sapiens	232-242
15516695-8	2005	Computer modeling of the HO-1/CPR complex showed that the guanidino group of Arg(185) is located within the hydrogen bonding distance of 2"-phosphate of NADPH, suggesting that Arg(185) contributes to the binding to CPR through an electrostatic interaction with the phosphate group.	Arginine	176-179	heme oxygenase 1	Homo sapiens	25-29
15649129-6	2005	The kAE1 (Arg(901)--&gt;stop) mutant has been studied in more detail, since the mistargeting kAE1 (Arg(901)--&gt;stop) from the basolateral to the apical membrane is consistent with the removal of a basolateral localization signal.	Arginine	99-102	O-sialoglycoprotein endopeptidase	Homo sapiens	93-97
15668489-3	2005	Nonsynonymous variants of EPHX1 at Tyr(113)His (exon 3) and His(139)Arg (exon 4) are associated, respectively, with low ((113)His) and high ((139)Arg) predicted activity.	Arginine	68-71	epoxide hydrolase 1	Homo sapiens	26-31
15664727-4	2005	A meta-analysis indicates that individuals homozygous for the p53 codon 72 Pro allele instead of the more prevalent Arg allele have a modest increase in cancer incidence.	Arginine	116-119	transformation related protein 53, pseudogene	Mus musculus	62-65
15664727-5	2005	This difference in cancer suspectibility is consistent with molecular studies showing that the p53 Pro polymorphic variant is a less robust anti-proliferative molecule than its Arg counterpart.	Arginine	177-180	transformation related protein 53, pseudogene	Mus musculus	95-98
15926857-2	2005	Peptides with the Glu-Ile-Leu-Asp-Val (EILDV) and Arg-Gly-Asp (RGD) sequences inhibit cell migration on fibronectin by binding to the fibronectin-recognition site in several integrins.	Arginine	50-53	fibronectin 1	Bos taurus	104-115
15926857-2	2005	Peptides with the Glu-Ile-Leu-Asp-Val (EILDV) and Arg-Gly-Asp (RGD) sequences inhibit cell migration on fibronectin by binding to the fibronectin-recognition site in several integrins.	Arginine	50-53	fibronectin 1	Bos taurus	134-145
15604266-3	2004	The majority of the heparin binding is mediated by arginines 155/158/184/270 in endostatin, but there is also a minor site constituted by arginines 193/194.	Arginine	51-60	collagen type XVIII alpha 1 chain	Homo sapiens	80-90
15604266-6	2004	These arginines were also required for endostatin to inhibit fibroblast growth factor-2- and vascular endothelial growth factor-A-induced chemotaxis of primary endothelial cells.	Arginine	6-15	collagen type XVIII alpha 1 chain	Homo sapiens	39-49
15530866-0	2004	MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1).	Arginine	22-30	H3 histone pseudogene 16	Homo sapiens	156-159
15743038-10	2004	The prevalence of the Arg allele of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene may contribute to the susceptibility to endometrial cancer among obese/overweight individuals.	Arginine	22-25	adrenoceptor beta 3	Homo sapiens	69-94
15498669-6	2004	The p-OAc substituent on the C-1 phenyl ring is oriented in a hydrophobic pocket comprised of Met(522), Gly(526), Trp(387), Tyr(348), and Tyr(385), and the C-2 ethyl substituent is oriented towards the mouth of the COX-2 channel in the vicinity of amino acid residues Arg(120), Leu(531), and Val(349).	Arginine	268-271	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	29-32
15292263-3	2004	Rap1 neither possesses a Gln nor does its cognate Rap-GAP employ an Arg.	Arginine	68-71	RAP1A, member of RAS oncogene family	Homo sapiens	0-4
15292263-3	2004	Rap1 neither possesses a Gln nor does its cognate Rap-GAP employ an Arg.	Arginine	68-71	LDL receptor related protein associated protein 1	Homo sapiens	0-3
15292263-12	2004	Thus, the Rap.RapGAP catalytic machinery compensates for the absence of a cis-Gln by a trans-Asn and for the catalytic Arg by inducing a different GTP conformation that is more prone to be attacked by a water molecule.	Arginine	119-122	LDL receptor related protein associated protein 1	Homo sapiens	10-13
15242333-2	2004	Arginine methylation of Ad (adenovirus) E1B 55-kDa-associated protein E1B-AP5 was recently described by us [Kzhyshkowska, Schutt, Liss, Kremmer, Stauber, Wolf and Dobner (2001) Biochem.	Arginine	0-8	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	70-77
15242333-5	2004	In this first example of protein arginine methylation analysis in Ad-infected cells, we investigated methylation of the E1B-AP5 and the viral L4-100 kDa protein.	Arginine	33-41	heterogeneous nuclear ribonucleoprotein U like 1	Homo sapiens	120-127
15450432-4	2004	hOGG1-Ser326 and -Cys326 have Arg at codon 46, and hOGG1-Gln46 has Ser at codon 326.	Arginine	30-33	8-oxoguanine DNA glycosylase	Homo sapiens	0-5
15465778-3	2004	L-arginine is catabolized by arginases, nitric oxide synthases, arginine:glycine amidinotransferase, and possibly also by arginine decarboxylase, resulting ultimately in the production of urea, proline, glutamate, polyamines, nitric oxide, creatine, or agmatine.	Arginine	0-10	antizyme inhibitor 2	Homo sapiens	122-144
15465793-2	2004	Citrulline that is formed as a by-product of the NOS reaction can be recycled to arginine by successive actions of argininosuccinate synthetase (AS) and argininosuccinate lyase (AL), forming the citrulline-NO cycle.	Arginine	81-89	argininosuccinate lyase	Rattus norvegicus	153-176
15334374-2	2004	The objective of this study is to investigate whether the ADRB3 Arg variant confers susceptibility to GDM in a Taiwanese population.	Arginine	64-67	adrenoceptor beta 3	Homo sapiens	58-63
15123679-9	2004	These data identify a third loss-of-function polymorphism affecting the human P2X(7) receptor, and since the affected Arg(307) is homologous to those amino acids essential for ATP binding to P2X(1) and P2X(2), it is likely that this polymorphism abolishes the binding of ATP to the extracellular domain of P2X(7).	Arginine	118-121	purinergic receptor P2X 2	Homo sapiens	202-208
15247425-3	2004	Here we report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site, -Arg(P4)-Arg-Lys-Arg(P1) downsream-, in its reactive site loop (RSL).	Arginine	203-206	Serpin 88Ea	Drosophila melanogaster	118-124
15247425-3	2004	Here we report the identification of Spn4A, a previously uncharacterized secretory pathway serine protease inhibitor (serpin) from Drosophila melanogaster that contains a consensus furin cleavage site, -Arg(P4)-Arg-Lys-Arg(P1) downsream-, in its reactive site loop (RSL).	Arginine	211-214	Serpin 88Ea	Drosophila melanogaster	118-124
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	106-109	Furin 1	Drosophila melanogaster	17-22
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Furin 1	Drosophila melanogaster	17-22
15247425-6	2004	Mass analysis of furin-Spn4A reaction products identified the actual reactive site center of Spn4A to be -Arg(P4)-Arg-Lys-Arg(P1)-downstream-.	Arginine	114-117	Furin 1	Drosophila melanogaster	17-22
15150161-6	2004	We demonstrate that the point mutation at arginine 451 and a nonsense mutation at aspartate 396 of neuroligin-3 and -4 (NL3 and NL4), respectively, result in intracellular retention of the mutant proteins.	Arginine	42-50	neuroligin 3	Homo sapiens	99-118
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Arginine	67-70	toll like receptor 4	Homo sapiens	215-219
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Arginine	67-70	toll like receptor 4	Homo sapiens	301-305
15254349-15	2004	TP53INP1 mRNA induction in acinar cells was confirmed with in vitro experiments using an arginine-induced rat pancreatic acinar AR4-2J cell injury model.	Arginine	89-97	tumor protein p53 inducible nuclear protein 1	Rattus norvegicus	0-8
15208393-5	2004	In mammalian MAPK phosphatases, the corresponding region serves as a docking motif for MAPKs, and analogous Arg substitutions severely inhibit the kinase-phosphatase association.	Arginine	108-111	mitogen-activated protein kinase 1	Arabidopsis thaliana	13-17
15252778-4	2004	L-arginine administration also blunts the increase in interstitial volume, collagen IV, and alpha-smooth muscle actin.	Arginine	0-10	actin gamma 2, smooth muscle	Rattus norvegicus	92-117
15178428-4	2004	Particularly, the dibasic Arg-Lys sequence located at the carboxy-terminal end of KHD was shown to be crucial for the plasma membrane targeting of PIP5Kgamma, since the deletion or charge-reversal mutation of this dibasic sequence resulted in the mislocalization of the protein to the cytoplasm.	Arginine	26-29	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	Homo sapiens	147-157
15033987-7	2004	Furthermore, co-immunoprecipitation of RyR1 with 33 various mutants for the 9 positions produced by introducing different size, charge, and hydrophobicity revealed that an integration of the hydrogen bonds by the irreplaceable Gln-3 and the hydrophobic interactions by the residues Arg-18 and Met-49 could be a possible mechanism for the binding of FKBP12 to RyR1.	Arginine	282-285	ryanodine receptor 1	Oryctolagus cuniculus	39-43
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	87-90	keratin 1	Mus musculus	51-54
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Mus musculus	51-54
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Mus musculus	51-54
15145734-10	2004	In the VEGF group, total and regional flap perfusion did not change after pedicle ligation, but perfusion decreased significantly in zones B through D in the L-arginine treated rats.	Arginine	158-168	vascular endothelial growth factor A	Rattus norvegicus	7-11
15198878-8	2004	A C5498T heterozygous mutation in exon 3 of protein C gene, resulting in the substitution of Arg for Trp at the 15th amino acid, was identified in propositus 1 and 8 of his relatives.	Arginine	93-96	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	44-53
15161794-1	2004	OBJECTIVE: The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea.	Arginine	91-94	insulin receptor substrate 1	Homo sapiens	100-128
15161794-1	2004	OBJECTIVE: The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea.	Arginine	91-94	insulin receptor substrate 1	Homo sapiens	130-135
15161794-5	2004	RESULTS: Of the total patients, 53 (11.1%) were heterozygous for the Arg(972) IRS-1 variant, 1 (0.2%) was homozygous, and the remainder (88.7%) were homozygous for the wild-type allele.	Arginine	69-72	insulin receptor substrate 1	Homo sapiens	78-83
15161794-6	2004	The genotype frequency of the Arg(972) IRS-1 variant was 8.7% among diabetic patients well controlled with oral therapy and 16.7% among patients with secondary failure to sulfonylurea (odds ratio 2.1 [95% CI 1.18-3.70], P = 0.01).	Arginine	30-33	insulin receptor substrate 1	Homo sapiens	39-44
15161794-8	2004	CONCLUSIONS: These data demonstrate that the Arg(972) IRS-1 variant is associated with increased risk for secondary failure to sulfonylurea, thus representing a potential example of pharmacogenetics in type 2 diabetes.	Arginine	45-48	insulin receptor substrate 1	Homo sapiens	54-59
15192815-7	2004	A mutation of CCC--&gt;CGC was detected at codon 534 of the ABCD1 gene from patient 1, resulting in the arginine for proline substitution.	Arginine	104-112	ATP binding cassette subfamily D member 1	Homo sapiens	60-65
15192815-9	2004	A mutation of CGC--&gt;GGC was found at codon 617 in one ABCD1 allele of the third patient"s mother, leading to the glycine for arginine substitution.	Arginine	128-136	ATP binding cassette subfamily D member 1	Homo sapiens	57-62
15147300-8	2004	No modulation of Ca(v)2.3 channels by PKC was observed when an arginine rich region in the II-III loop of Ca(v)2.3 was eliminated.	Arginine	63-71	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	106-114
15099969-3	2004	An association between endometrial cancer and the polymorphism at codon 31 (AGC/serine to AGA/arginine [Ser(31)Arg]) of the p21 gene, which is known to be a downstream mediator of p53, has also been reported.	Arginine	94-102	H3 histone pseudogene 16	Homo sapiens	124-127
15099969-8	2004	Also, homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing endometrial cancer (OR 2.68, 95% CI 1.59-4.51) as compared to homozygous and heterozygous carriers of the Arg allele.	Arginine	206-209	H3 histone pseudogene 16	Homo sapiens	33-36
15105550-4	2004	Arginine-to-asparagine substitutions in this region decreased the level of the ORF3 protein accumulation in nuclei.	Arginine	0-8	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	79-83
15059894-3	2004	In this study, we demonstrated that its NH(2)-terminal portion [soluble GPC3 (sGPC3)] is cleaved between Arg(358) and Ser(359) of GPC3 and that sGPC3 can be specifically detected in the sera of patients with HCC.	Arginine	105-108	glypican 3	Homo sapiens	72-76
15059894-3	2004	In this study, we demonstrated that its NH(2)-terminal portion [soluble GPC3 (sGPC3)] is cleaved between Arg(358) and Ser(359) of GPC3 and that sGPC3 can be specifically detected in the sera of patients with HCC.	Arginine	105-108	glypican 3	Homo sapiens	79-83
15039296-0	2004	Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).	Arginine	14-22	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	84-103
15039296-0	2004	Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).	Arginine	14-22	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	105-111
14613933-11	2004	In vitro analysis of this mutant also revealed a 2-fold reduced affinity for VWF propeptide at low pH, showing that mutation of Arg-1205 results not only in an increased clearance rate but is also associated with an impaired pH-dependent interaction with VWF propeptide.	Arginine	128-131	Von Willebrand factor	Mus musculus	77-80
14613933-11	2004	In vitro analysis of this mutant also revealed a 2-fold reduced affinity for VWF propeptide at low pH, showing that mutation of Arg-1205 results not only in an increased clearance rate but is also associated with an impaired pH-dependent interaction with VWF propeptide.	Arginine	128-131	Von Willebrand factor	Mus musculus	255-258
15039704-6	2004	Structural analysis and mutagenesis show that binding of N-Aha1 promotes a conformational switch in the middle-segment catalytic loop (370-390) of Hsp90 that releases the catalytic Arg 380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone.	Arginine	181-184	heat shock protein 90 alpha family class A member 1	Homo sapiens	147-152
14684736-3	2004	The cyclin L2 protein contains an N-terminal "cyclin box" and C-terminal dipeptide repeats of alternating arginines and serines, a hallmark of the SR family of splicing factors.	Arginine	106-115	proliferating cell nuclear antigen	Homo sapiens	4-10
14990791-0	2004	Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.	Arginine	65-73	protein kinase cGMP-dependent 1	Homo sapiens	82-98
14990791-9	2004	Thus, the activation of the arginine/NO/cGMP pathway causes direct blockade of acute and persistent hypernociception by opening K(ATP)(+) via the stimulation of PKG.	Arginine	28-36	protein kinase cGMP-dependent 1	Homo sapiens	161-164
14699168-12	2004	These results suggest that residues Lys-68, Phe-185, Phe-291, Arg-292, and Lys-309 contribute to ligand binding at P2X(1) receptors, with Phe-185 and Phe-291 coordinating the binding of the adenine ring of ATP.	Arginine	62-65	purinergic receptor P2X 1	Homo sapiens	115-121
14970387-7	2004	These studies indicate that the Tat arginine-rich motif, in addition to its known binding site at the bulge, is in close contact with U31 in the TAR loop.	Arginine	36-44	small nucleolar RNA, C/D box 31	Homo sapiens	134-137
14570910-12	2004	We established cells that stably express mutant TLP lacking TFIIA binding ability and identified the amino acids of TLP required for TFIIA binding (Ala-32, Leu-33, Asn-37, Arg-52, Lys-53, Lys-78, and Arg-86).	Arginine	200-203	general transcription factor IIA subunit 2	Homo sapiens	133-138
14770441-1	2004	BACKGROUND: Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine.	Arginine	101-109	argininosuccinate synthase 1	Homo sapiens	12-40
14770441-1	2004	BACKGROUND: Argininosuccinate synthetase (ASS) was the first of two enzymes to convert citrulline to arginine.	Arginine	101-109	argininosuccinate synthase 1	Homo sapiens	42-45
14770441-11	2004	CONCLUSIONS: These data indicated that immunohistochemical detection of ASS may prove an effective means for determining ASS deficiency in malignant human tumors and for identifying patients most likely to respond to arginine deprivation therapy.	Arginine	217-225	argininosuccinate synthase 1	Homo sapiens	72-75
14676199-3	2004	The protein is similar to the other two serine/arginine (SR)-type proteins in yeast, Gbp2 and Npl3.	Arginine	47-55	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	85-89
14757744-7	2004	Most intriguingly, the CDR3 regions of the ANAs exhibited alternating arginine/lysine peaks at H96, H98, and H100, with neutral troughs at H95, H97, and H99.	Arginine	70-78	cerebellar degeneration-related 3	Mus musculus	23-27
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	RAS p21 protein activator 1	Mus musculus	159-165
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	Casitas B-lineage lymphoma	Mus musculus	167-170
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	signal transducer and activator of transcription 5A	Mus musculus	172-177
15002734-0	2004	Arginine administration decreases cerebral cortex acetylcholinesterase and serum butyrylcholinesterase probably by oxidative stress induction.	Arginine	0-8	acetylcholinesterase	Rattus norvegicus	50-70
15002734-1	2004	In the present study we investigated the action of vitamins E and C on the inhibition of acetylcholinesterase and butyrylcholinesterase activities provoked by arginine in cerebral cortex and serum of 60-day-old rats.	Arginine	159-167	acetylcholinesterase	Rattus norvegicus	89-109
15002734-4	2004	Results showed that acetylcholinesterase and butyrylcholinesterase activities were decreased in the arginine-treated rats.	Arginine	100-108	acetylcholinesterase	Rattus norvegicus	20-40
15002734-6	2004	The data indicate that the reduction of acetylcholinesterase and butyrylcholinesterase activities caused by arginine was probably mediated by oxidative stress.	Arginine	108-116	acetylcholinesterase	Rattus norvegicus	40-60
14585835-6	2004	Molecular modeling of the complex between endostatin and heparin oligosaccharides predicted that, compared with mutagenesis studies, two further arginine residues, Arg(47) and Arg(66), participated in the binding.	Arginine	145-153	collagen type XVIII alpha 1 chain	Homo sapiens	42-52
14585835-6	2004	Molecular modeling of the complex between endostatin and heparin oligosaccharides predicted that, compared with mutagenesis studies, two further arginine residues, Arg(47) and Arg(66), participated in the binding.	Arginine	164-167	collagen type XVIII alpha 1 chain	Homo sapiens	42-52
14585835-6	2004	Molecular modeling of the complex between endostatin and heparin oligosaccharides predicted that, compared with mutagenesis studies, two further arginine residues, Arg(47) and Arg(66), participated in the binding.	Arginine	176-179	collagen type XVIII alpha 1 chain	Homo sapiens	42-52
14698290-7	2004	We show here that the serine to arginine change in the Rad50 protein prevents ATP binding and disrupts the communication among the other ATP-binding loops.	Arginine	32-40	MRX complex DNA-binding subunit	Saccharomyces cerevisiae S288C	55-60
14734530-7	2004	During erythroid differentiation, increased arginine methylation coincided with BTG1 expression.	Arginine	44-52	BTG anti-proliferation factor 1	Mus musculus	80-84
15094825-1	2004	Interleukin-1 receptor antagonist (IL-1Ra) and vaccinia virus protein C10L share a VTXFYF motif, with X being Lys or Arg residue, respectively.	Arginine	117-120	interleukin 1 receptor antagonist	Homo sapiens	35-41
15844633-1	2004	The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC).	Arginine	4-12	serpin family B member 3	Homo sapiens	243-246
14694156-6	2004	Site-directed mutagenesis of a conserved arginine (R1496 in AnkG190), previously shown to be critical for the binding of Fas (R234 in Fas) to FADD, abolished the interaction of ankyrin"s death domain with Fas.	Arginine	41-49	Fas (TNFRSF6)-associated via death domain	Mus musculus	142-146
14978339-2	2004	Twenty-nine spontaneous mutants from the hybrid CCMV capable of systemic infection in cowpea appeared through biased codon changes that resulted in Lys or Arg at five specific positions in the MP gene.	Arginine	155-158	movement protein	Cowpea chlorotic mottle virus	193-195
14592468-1	2003	A short stretch of 13 amino acids in the central portion of human beta-casein contains four positively charged conserved residues, three Lys and one Arg.	Arginine	149-152	casein beta	Homo sapiens	66-77
14602908-7	2003	Truncation experiments with the RS domain of the human SR protein 9G8 identified a 29 amino acid segment, containing 26 arginine or serine residues, that is sufficient to activate splicing when fused to MS2.	Arginine	120-128	MS2	Homo sapiens	203-206
14579251-1	2003	Peptidylarginine deiminase (PAD, EC 3.5.3.15) enzymes catalyze the conversion of protein-bound arginine to citrulline.	Arginine	8-16	peptidyl arginine deiminase 4	Homo sapiens	28-31
14640960-2	2003	The problem of 11 arginine codons, rare in procaryotes, in the tobacco peroxidase gene was solved using E. coli BL21(DE3) Codon Plus strain.	Arginine	18-26	lignin-forming anionic peroxidase-like	Nicotiana tabacum	71-81
12860992-0	2003	A kinesin switch I arginine to lysine mutation rescues microtubule function.	Arginine	19-27	Kinesin light chain	Drosophila melanogaster	2-9
14514346-8	2003	Molecular genetic analysis revealed a 747 CGA (Arg)-TGA (End) mutation in exon 22 of the PHEX gene, confirming XLH.	Arginine	47-50	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	89-93
14572312-1	2003	BACKGROUND: Arginine metabolism in tumor cell lines can be influenced by various cytokines, including recombinant human interferon-gamma (rIFN-gamma), a cytokine that shows promising clinical activity in epithelial ovarian cancer (EOC).	Arginine	12-20	interferon gamma	Rattus norvegicus	138-148
14572312-12	2003	Since cells within the stroma of EOC tissues could also contribute to arginine metabolism following treatment with rIFN-gamma or rIFN-gamma-inducers, it would be helpful to examine these effects in vivo.	Arginine	70-78	interferon gamma	Rattus norvegicus	115-139
13129532-4	2003	Nitric oxide (NO) synthesised from L-arginine via endothelial NO-synthase (eNOS) is involved in the control of vascular tone and permeability.	Arginine	35-45	nitric oxide synthase 3, endothelial cell	Mus musculus	50-73
13129532-4	2003	Nitric oxide (NO) synthesised from L-arginine via endothelial NO-synthase (eNOS) is involved in the control of vascular tone and permeability.	Arginine	35-45	nitric oxide synthase 3, endothelial cell	Mus musculus	75-79
12807887-6	2003	Adhesion to microfibrils and to Arg-Gly-Asp containing fibrillin-1 protein fragments induced signaling events that led to cell spreading, altered cytoskeletal organization, and enhanced extracellular fibrillin-1 deposition.	Arginine	32-35	fibrillin 1	Homo sapiens	55-66
12807887-6	2003	Adhesion to microfibrils and to Arg-Gly-Asp containing fibrillin-1 protein fragments induced signaling events that led to cell spreading, altered cytoskeletal organization, and enhanced extracellular fibrillin-1 deposition.	Arginine	32-35	fibrillin 1	Homo sapiens	200-211
12807887-8	2003	An Arg-Gly-Asp-independent cell adhesion sequence was also identified within fibrillin-1.	Arginine	3-6	fibrillin 1	Homo sapiens	77-88
12807887-10	2003	A375-SM melanoma cells bound Arg-Gly-Asp-containing fibrillin-1 protein fragments mainly through alpha v beta 3, whereas HT1080 cells used mainly alpha 5 beta 1.	Arginine	29-32	fibrillin 1	Homo sapiens	52-63
12939144-10	2003	We suggest that the Phe77Leu mutation causes conformational changes around the top of the D-helix in antithrombin, in particular, to the arginine 132 and 133 residues that may mediate additional antithrombin/heparin interactions.	Arginine	137-145	serpin family C member 1	Homo sapiens	101-113
12939144-10	2003	We suggest that the Phe77Leu mutation causes conformational changes around the top of the D-helix in antithrombin, in particular, to the arginine 132 and 133 residues that may mediate additional antithrombin/heparin interactions.	Arginine	137-145	serpin family C member 1	Homo sapiens	195-207
12956948-4	2003	RESULTS: X-ray crystallographic analysis of the Cdc42-RhoGDI complex suggested that arginine 66 of Cdc42 is essential for its interaction with RhoGDI.	Arginine	84-92	Rho GDP dissociation inhibitor alpha	Homo sapiens	143-149
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	37-45	Rho GDP dissociation inhibitor alpha	Homo sapiens	146-152
12956948-5	2003	Here we show that mutation of either arginine 66 or arginine 68 within the Switch II domain of Cdc42 completely abolished the binding of Cdc42 to RhoGDI without affecting the binding of other known regulators or target/effectors of this GTP binding protein.	Arginine	52-60	Rho GDP dissociation inhibitor alpha	Homo sapiens	146-152
12888343-8	2003	Further analyses of the direct contacts in the interface between the helix-3 region of Ets-1 and the major groove of the core DNA sequence clearly show that the highly conserved arginine residues, Arg391 and Arg394, play a critical role in binding to the GGAA core sequence.	Arginine	178-186	ETS proto-oncogene 1, transcription factor	Homo sapiens	87-92
12885237-13	2003	The reduced efficiency of COX-1-mediated, AEA oxygenation can thus be explained by the absence of an arginine residue at position 513 in this isoform.	Arginine	101-109	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	26-31
12733990-11	2003	The substrates Abz-KPRGSKQ-EDDnp and Abz-KKPGSKQ-EDDnp were cleaved by cathepsin K at the Arg-Gly and Gly-Ser bonds respectively, and have been shown to be specific for cathepsin K when compared with other lysosomal cysteine proteases such as cathepsins L and B and with the aspartyl protease cathepsin D.	Arginine	90-93	cathepsin K	Homo sapiens	71-82
12733990-11	2003	The substrates Abz-KPRGSKQ-EDDnp and Abz-KKPGSKQ-EDDnp were cleaved by cathepsin K at the Arg-Gly and Gly-Ser bonds respectively, and have been shown to be specific for cathepsin K when compared with other lysosomal cysteine proteases such as cathepsins L and B and with the aspartyl protease cathepsin D.	Arginine	90-93	cathepsin K	Homo sapiens	169-180
12746441-3	2003	In this study, by systematic deletion and site-directed mutagenesis we identified Arg-214/215 in the alpha-helix 2 region of the coiled-coil domain of Stat3 as a novel sequence element essential for its nuclear translocation, stimulated by epidermal growth factor as well as by interleukin-6.	Arginine	82-85	epidermal growth factor	Homo sapiens	240-263
12746441-7	2003	The mutant of Arg-214/215 or Arg-414/417 was shown to be tyrosyl-phosphorylated normally but failed to enter the nucleus in response to epidermal growth factor or interleukin-6.	Arginine	14-17	epidermal growth factor	Homo sapiens	136-159
12874210-4	2003	Human T cells stimulated and cultured in the absence of L-arginine lose the expression of the TCR zeta-chain (CD3zeta) and have an impaired proliferation and a decreased cytokine production.	Arginine	56-66	CD247 molecule	Homo sapiens	94-108
12874210-4	2003	Human T cells stimulated and cultured in the absence of L-arginine lose the expression of the TCR zeta-chain (CD3zeta) and have an impaired proliferation and a decreased cytokine production.	Arginine	56-66	CD247 molecule	Homo sapiens	110-117
12874210-7	2003	Competitive inhibitors of ASE I or the addition of excess L-arginine lead to the re-expression of CD3zeta and recovery of T cell proliferation.	Arginine	58-68	CD247 molecule	Homo sapiens	98-105
12846563-4	2003	Mutagenesis of P6-P3" reactive loop residues of antithrombin further reveals that the reactivity of the unactivated inhibitor is principally determined by the P1 Arg residue, whereas exosites outside the loop which are present on the activated serpin and on heparin are responsible for heparin enhancement of this reactivity.	Arginine	162-165	serpin family C member 1	Homo sapiens	48-60
12828642-7	2003	Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p.	Arginine	35-43	inositol polyphosphate multikinase	Saccharomyces cerevisiae S288C	0-6
12828642-7	2003	Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p.	Arginine	35-43	Arg80p	Saccharomyces cerevisiae S288C	81-87
12828642-7	2003	Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p.	Arginine	35-43	transcription factor MCM1	Saccharomyces cerevisiae S288C	92-97
12828642-7	2003	Arg82p also controls expression of arginine-responsive genes by interacting with Arg80p and Mcm1p, and expression of Mcm1-dependent genes by interacting with Mcm1p.	Arginine	35-43	transcription factor MCM1	Saccharomyces cerevisiae S288C	92-96
12804532-7	2003	Sequence analysis of anti-dsDNA hybridomas derived from TdT(-) mice revealed a lack of N additions, short VH CDR3 segments, yet the presence of VH CDR3 arginines.	Arginine	152-161	cerebellar degeneration-related 3	Mus musculus	147-151
12873715-5	2003	Taken together our results indicate that dietary arginine plays a relevant role in the maintenance of the sexual dimorphism in arginine content and arginine metabolism in CD1 mice, and that this may have physiological significance because of the important effects that arginine-derived products exert on a variety of cellular processes.	Arginine	49-57	CD1 antigen complex	Mus musculus	171-174
12571234-8	2003	The N-terminal residue Arg-8, preceding the first cysteine, was critical for CXCR3 signaling.	Arginine	23-26	chemokine (C-X-C motif) receptor 3	Mus musculus	77-82
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Arginine	201-204	dihydrofolate reductase	Homo sapiens	276-280
15228255-8	2003	Moreover, the prevalence of infections with only 2 mutations (Asn-108 plus Ile-51) was significantly and inversely correlated to the prevalence of infections with 3 mutations (Asn-108 plus Ile-51 plus Arg-59) (r = 0.92, P = 0.004), suggesting the stepwise accumulation of the dhfr mutations is Asn-108 Ile-51 Arg-59 and further supporting the idea of using the dhfr codon 59 M/W ratio as a molecular index for the prediction of SP treatment failure.	Arginine	201-204	dihydrofolate reductase	Homo sapiens	361-365
12591924-0	2003	Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis.	Arginine	15-23	serpin family C member 1	Homo sapiens	35-47
12591924-0	2003	Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis.	Arginine	15-23	serpin family C member 1	Homo sapiens	57-69
12591924-2	2003	Sequencing of the antithrombin genes of the patient revealed that one of the two alleles was abnormal due to an in-frame deletion of the codon for the P1 arginine residue.	Arginine	154-162	serpin family C member 1	Homo sapiens	18-30
12551932-12	2003	The arginine-rich domain of Tat was essential for both the LTR transactivation and the neurotoxic properties of Tat.	Arginine	4-12	tyrosine aminotransferase	Rattus norvegicus	28-31
12551932-12	2003	The arginine-rich domain of Tat was essential for both the LTR transactivation and the neurotoxic properties of Tat.	Arginine	4-12	tyrosine aminotransferase	Rattus norvegicus	112-115
12639933-4	2003	Binding of glomerulosa cells to fibronectin, but not to collagen I or poly-L-lysine, involved the integrin-binding sequence Arg-Gly-Asp (RGD).	Arginine	124-127	fibronectin 1	Rattus norvegicus	32-43
12631354-8	2003	L-Arginine administration increased albuminuria, renal matrix accumulation, TGF-beta 1, fibronectin, PAI-1, blood L-arginine, L-citrulline, BUN and blood and urine NOx levels, while protein restriction reduced these parameters.	Arginine	0-10	fibronectin 1	Mus musculus	88-99
12631354-8	2003	L-Arginine administration increased albuminuria, renal matrix accumulation, TGF-beta 1, fibronectin, PAI-1, blood L-arginine, L-citrulline, BUN and blood and urine NOx levels, while protein restriction reduced these parameters.	Arginine	0-10	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	101-106
12633747-6	2003	We demonstrated that Arg specifically and dose-dependently induces pancreatitis, activates NF-kappaB (only the 3 g/kg dose) and proinflammatory cytokine synthesis, and increases the expressions of HSP60 and HSP72 in the pancreas of rats.	Arginine	21-24	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	197-202
12519764-10	2003	At high Ca(2+), HSP90 caused the V(max) of eNOS for l-arginine to increase by 2-fold, but the K(m) of eNOS was unchanged.	Arginine	52-62	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-21
12606535-1	2003	The Arg(972) insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic beta-cell stimulus-coupled insulin secretion and survival.	Arginine	4-7	insulin receptor substrate 1	Homo sapiens	43-48
12606535-2	2003	We analyzed the relations between type 1 diabetes and the Arg(972) IRS-1 variant.	Arginine	58-61	insulin receptor substrate 1	Homo sapiens	67-72
12606535-3	2003	The frequency of the IRS-1 Arg(972) variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes simplex families.	Arginine	27-30	insulin receptor substrate 1	Homo sapiens	21-26
12606535-4	2003	In the former group, frequency of the IRS-1 Arg(972) variant was significantly increased in the patients (P = 0.0008), conferring an OR of 2.5.	Arginine	44-47	insulin receptor substrate 1	Homo sapiens	38-43
12606535-5	2003	Transmission disequilibrium analysis of data obtained from the family set revealed that the Arg(972) IRS-1 variant was transmitted from heterozygous parents to affected probands at a frequency of 70.2% (P &lt; 0.02).	Arginine	92-95	insulin receptor substrate 1	Homo sapiens	101-106
12606535-7	2003	Arg(972) IRS-1 type 1 diabetic patients also had lower fasting plasma concentrations of C-peptide at the time of diagnosis with respect to patients carrying the wild-type IRS-1 (0.49 +/- 0.058, n = 34, and 0.76 +/- 0.066, n = 134, respectively [means +/- SE]; P = 0.051).	Arginine	0-3	insulin receptor substrate 1	Homo sapiens	9-14
12606535-7	2003	Arg(972) IRS-1 type 1 diabetic patients also had lower fasting plasma concentrations of C-peptide at the time of diagnosis with respect to patients carrying the wild-type IRS-1 (0.49 +/- 0.058, n = 34, and 0.76 +/- 0.066, n = 134, respectively [means +/- SE]; P = 0.051).	Arginine	0-3	insulin receptor substrate 1	Homo sapiens	171-176
12606535-8	2003	Our findings suggest a role for Arg(972) IRS-1 in conferring risk for the development of type 1 diabetes.	Arginine	32-35	insulin receptor substrate 1	Homo sapiens	41-46
12628849-7	2003	Among the TP53 amplified samples, the rate of Arg homozygosity in penile SCC was 61% compared with 68% in BL (non-significant (NS)).	Arginine	46-49	serpin family B member 3	Homo sapiens	73-76
12626632-3	2003	Using immunoelectron microscopy, we have localized Abl and Arg to the pre- and postsynaptic compartments of synapses in the mouse hippocampal area CA1.	Arginine	59-62	carbonic anhydrase 1	Mus musculus	147-150
12626632-4	2003	Paired-pulse facilitation (PPF) was significantly reduced at the Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal slices from abl-/- and arg-/- mice as compared with wild-type mice.	Arginine	156-159	carbonic anhydrase 1	Mus musculus	85-88
12626632-4	2003	Paired-pulse facilitation (PPF) was significantly reduced at the Schaffer collateral-CA1 (SC-CA1) excitatory synapses in hippocampal slices from abl-/- and arg-/- mice as compared with wild-type mice.	Arginine	156-159	carbonic anhydrase 1	Mus musculus	93-96
12594045-6	2003	SFRS14 also contains an N-terminal region that is rich in arginine/serine residues, suggesting SFRS14 is a novel member of the SR-related family of pre-mRNA processing factors.	Arginine	58-66	SURP and G-patch domain containing 2	Homo sapiens	0-6
12594045-6	2003	SFRS14 also contains an N-terminal region that is rich in arginine/serine residues, suggesting SFRS14 is a novel member of the SR-related family of pre-mRNA processing factors.	Arginine	58-66	SURP and G-patch domain containing 2	Homo sapiens	95-101
12446675-5	2003	Mutating the basic charged arginine residues in all four IQ motifs abrogated binding of IQGAP1 to apocalmodulin, but had no effect on its interaction with Ca(2+)/calmodulin.	Arginine	27-35	IQ motif containing GTPase activating protein 1	Homo sapiens	88-94
12546692-4	2003	There are now several lines of evidence supporting our interpretation that the RN(-) phenotype is caused by a missense mutation (Arg(200)--&gt;Gln) in PRKAG3.	Arginine	129-132	protein kinase AMP-activated non-catalytic subunit gamma 3	Sus scrofa	151-157
12538786-2	2003	Here we describe the activities and mRNA expression patterns of other key enzymes in the arginine biosynthetic pathway, specifically carbamoyl phosphate synthase I (CPS-I), ornithine carbamoyl transferase (OCT), and pyrroline-5-carboxylate reductase (P5CR), in the fetal porcine small intestine from 30 to 110 d of gestation.	Arginine	89-97	ornithine transcarbamylase	Sus scrofa	173-204
12538786-2	2003	Here we describe the activities and mRNA expression patterns of other key enzymes in the arginine biosynthetic pathway, specifically carbamoyl phosphate synthase I (CPS-I), ornithine carbamoyl transferase (OCT), and pyrroline-5-carboxylate reductase (P5CR), in the fetal porcine small intestine from 30 to 110 d of gestation.	Arginine	89-97	ornithine transcarbamylase	Sus scrofa	206-209
15199491-2	2003	In most cases, APC resistance is associated with a single missense mutation in the gene for coagulation factor V (FV (Leiden)), which predicts the replacement of Arg (506) with a Gln at one of the cleavage sites for APC in factor V. Factor V is a Janus-faced protein with dual functions, serving as an essential nonenzymatic cofactor in both pro- and anticoagulant pathways.	Arginine	162-165	coagulation factor V	Homo sapiens	92-112
12504905-2	2003	Consistent with the X-ray crystal structures of RARalpha and RARgamma, site-directed mutagenesis studies have demonstrated the importance of a conserved Arg residue (alphaArg(276), betaArg(269), and gammaArg(278)) for coordination with the carboxyl group of RA.	Arginine	153-156	retinoic acid receptor alpha	Homo sapiens	48-56
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	320-323	retinoic acid receptor alpha	Homo sapiens	139-147
12504905-7	2003	Finally, a homology-based computer model of the ligand binding domain (LBD) of RARbeta and the X-ray crystal structures of the LBD of both RARalpha and RARgamma are used to describe potential mechanisms responsible for the increased affinity of some mutants for Am580 and for the difference in the effect of mutation of Arg(269) in RARbeta compared to its homologous Arg in RARalpha and RARgamma.	Arginine	367-370	retinoic acid receptor alpha	Homo sapiens	139-147
12417589-4	2003	Our studies show first that the protease could cleave P22 at the C-terminal side of Arg(167) or Arg(154) and second, that the maturation process can be either done in one step or in two steps with the generation of a processing intermediate (P20).	Arginine	84-87	calcineurin like EF-hand protein 1	Homo sapiens	54-57
12467633-2	2003	Further SAR studies resulted in the discovery of Penta-5-BrAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and Penta-5-Me(2)NAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) which are potent hMC4R agonists and are inactive in hMC1R, hMC3R and hMC5R agonist assays.	Arginine	74-77	melanocortin 1 receptor	Homo sapiens	215-220
12818000-2	2003	The aspartyl-glycine (DG) site within CTX is synthesised in the L-aspartyl peptide (alphaL) form, but converts to the age-modified forms L-isoaspartyl peptide (betaL) and D-aspartyl peptide (alphaD) over time.	Arginine	64-66	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	38-41
12601557-4	2003	We characterized two novel and one already described single-nucleotide polymorphism in the coding region of the RECQL4 gene, which were shown by the exonic splicing enhancer (ESE) score matrix to fall into high-score motifs recognized by serine/arginine-rich proteins.	Arginine	245-253	RecQ like helicase 4	Homo sapiens	112-118
12971260-0	2003	L-arginine enhances heat-induced depression of neuronal activity in the rat hippocampal CA1 area.	Arginine	0-10	carbonic anhydrase 1	Rattus norvegicus	88-91
12971260-1	2003	Effects of L-arginine on the heat-induced depression of the neuronal activity in the hippocampal CA1 area were investigated using optical recording techniques.	Arginine	11-21	carbonic anhydrase 1	Rattus norvegicus	97-100
12501191-6	2002	The arginine of the RXL motif contacts a glutamate, Glu220, on the cyclin.	Arginine	4-12	proliferating cell nuclear antigen	Homo sapiens	67-73
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	145-148	leishmanolysin like peptidase	Homo sapiens	105-109
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	leishmanolysin like peptidase	Homo sapiens	105-109
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	leishmanolysin like peptidase	Homo sapiens	105-109
12487813-3	2002	Furin has been shown to be necessary for the processing of a number of viral envelope glycoproteins, and gp63 contains a consensus sequence (305)Arg-Arg-Arg-Arg, which is a furin substrate motif.	Arginine	149-152	leishmanolysin like peptidase	Homo sapiens	105-109
12421968-2	2002	A serine to arginine (S128R) polymorphism in E-selectin has been reported at increased frequency in patients with systemic lupus erythematosus and atherosclerosis.	Arginine	12-20	selectin E	Homo sapiens	45-55
12523648-1	2002	Fibrillarin is a conserved nucleolar SnoRNP with a diverse N-terminal glycine- and arginine-rich (GAR) domain in most eukaryotes.	Arginine	83-91	fibrillarin	Mus musculus	0-11
12165435-5	2002	Monoclonal antibody E11 appeared to bind to the arginine-rich N-terminus of hLF, which is the binding site for heparin, bacterial lipopolysaccharide, human lysozyme, DNA and receptors.	Arginine	48-56	HLF transcription factor, PAR bZIP family member	Homo sapiens	76-79
12105220-8	2002	Point mutations in Snl1p that disrupted the conserved residues Glu-112 and Arg-141, equivalent to Glu-212 and Arg-237 in Bag-1M, abolished the interaction with Hsp70 proteins.	Arginine	75-78	Snl1p	Saccharomyces cerevisiae S288C	19-24
12105220-8	2002	Point mutations in Snl1p that disrupted the conserved residues Glu-112 and Arg-141, equivalent to Glu-212 and Arg-237 in Bag-1M, abolished the interaction with Hsp70 proteins.	Arginine	110-113	Snl1p	Saccharomyces cerevisiae S288C	19-24
12385583-10	2002	In the present study, mutation of the p53 gene was detected in three DMBA-induced leukemias as follows: a single-base substitution (CAT to CGT) at codon 177 (exon 5), resulting in an amino-acid change from Arg to Leu, a CGG to CTG/CGG changed at codon 211 (exon 6) resulting in an amino-acid change from His to Arg/His, and a GGG to TGG at codon 242 (exon 6) resulting in an amino-acid change from Gly to Trp, respectively.	Arginine	311-314	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
12097318-7	2002	We also demonstrate that, like its mammalian homolog PRMT1, Rmt1 specifically dimethylates an arginine residue at position 3 of histone H4 N-terminal tail.	Arginine	94-102	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	60-64
12177166-6	2002	Finally, substitution of the unique tyrosine residue within the basic helix-loop-helix (bHLH) portion of nuclear SREBPs with arginine, the conserved residue found in all other bHLH proteins, abolishes the transactivity of all SREBPs for SRE, and conversely results in markedly increased activity of SREBP-1 but not activity of SREBP-2 for E-boxes.	Arginine	125-133	sterol regulatory element binding transcription factor 1	Homo sapiens	299-306
11986308-0	2002	Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.	Arginine	0-8	flap structure-specific endonuclease 1	Homo sapiens	37-56
11986308-5	2002	Using human FEN-1 in this study, we identified two positively charged amino acid residues, Arg-47 and Arg-70 in human FEN-1, as candidates responsible for substrate binding.	Arginine	91-94	flap structure-specific endonuclease 1	Homo sapiens	12-17
11986308-5	2002	Using human FEN-1 in this study, we identified two positively charged amino acid residues, Arg-47 and Arg-70 in human FEN-1, as candidates responsible for substrate binding.	Arginine	91-94	flap structure-specific endonuclease 1	Homo sapiens	118-123
11986308-5	2002	Using human FEN-1 in this study, we identified two positively charged amino acid residues, Arg-47 and Arg-70 in human FEN-1, as candidates responsible for substrate binding.	Arginine	102-105	flap structure-specific endonuclease 1	Homo sapiens	12-17
11986308-5	2002	Using human FEN-1 in this study, we identified two positively charged amino acid residues, Arg-47 and Arg-70 in human FEN-1, as candidates responsible for substrate binding.	Arginine	102-105	flap structure-specific endonuclease 1	Homo sapiens	118-123
12074941-0	2002	Involvement of the nitric oxide/L-arginine and sympathetic nervous systems on the vasodepressor action of human urotensin II in anesthetized rats.	Arginine	32-42	urotensin 2	Homo sapiens	112-124
12074941-7	2002	The results suggest that the depressor response to human urotensin II is partially mediated via the NO/L-arginine pathway, and is suppressed by activity of the sympathetic nervous system.	Arginine	103-113	urotensin 2	Homo sapiens	57-69
12197387-4	2002	Three of four modified Arg residues are supposed to be within the 178RRHRGGS184 cluster, which was localized in the superficial loop of the scu-PA globule and was shown to interact with the complementary series of negatively charged residues in the molecule of the main plasma inhibitor PAI-1.	Arginine	23-26	serpin family E member 1	Homo sapiens	287-292
12197387-5	2002	The neutralization of positively charged Arg residues in this cluster decreases the affinity of scu-PA and the double chain urokinase-type plasminogen activator for PAI-1, which results in an enhancement of the stability in plasma and the fibrinolytic efficiency of the activator.	Arginine	41-44	serpin family E member 1	Homo sapiens	165-170
12172963-1	2002	Gene CPA1, encoding one of the subunits of carbamoylphosphate synthetase (CPSase A) is subject to a translational control by arginine of which the essential element is a 25 amino acid peptide encoded by the CPA1 messenger.	Arginine	125-133	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	5-9
12172963-1	2002	Gene CPA1, encoding one of the subunits of carbamoylphosphate synthetase (CPSase A) is subject to a translational control by arginine of which the essential element is a 25 amino acid peptide encoded by the CPA1 messenger.	Arginine	125-133	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	207-211
12172963-3	2002	In the past, a series of mutations impairing the repression of gene CPA1 by arginine had been selected in vivo.	Arginine	76-84	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	68-72
12172963-6	2002	Deletion of UPF1, or deletion of UPF2 and UPF3, the other genes involved in the NMD pathway, enhances the synthesis of CPSase A, whether arginine is present or not in the growth medium.	Arginine	137-145	ATP-dependent RNA helicase NAM7	Saccharomyces cerevisiae S288C	12-16
12172963-8	2002	Our results indicate that the NMD destabilizes the 5" end of the CPA1 message and this decay is strongly enhanced when arginine is present in the growth medium.	Arginine	119-127	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	65-69
12065490-7	2002	and found that on the basis of the presence or absence of arginine-143 of YopP (K. Ruckdeschel, K. Richter, O. Mannel, and J. Heesemann, Infect.	Arginine	58-66	yopP	Yersinia enterocolitica	74-78
12069594-14	2002	We conclude that arginine residues 33 and 35, which are believed to be directly involved in forming contacts to acidic receptor residues at the membrane-water interface, are no longer fixed in a well-defined conformation close to the membrane surface in [Ala(31), Pro(32)]-NPY.	Arginine	17-25	neuropeptide Y	Homo sapiens	273-276
12080468-6	2002	It is also shown that multiple signaling molecules, including PI3K, SHC, ras-GAP and CRK-L, are tyrosine phosphorylated in Ba/F3 cells that express ETV6/ARG.	Arginine	153-156	RAS p21 protein activator 1	Mus musculus	73-80
11950832-0	2002	Regulation of T cell receptor CD3zeta chain expression by L-arginine.	Arginine	58-68	CD247 molecule	Homo sapiens	30-37
11950832-4	2002	The data presented here demonstrate that Jurkat T cells cultured in medium without L-Arg (L-Arg-free RPMI) have a rapid decrease in the expression of the T cell antigen receptor zeta chain (CD3zeta), the principal signal transduction element in this receptor, and a decrease in T cell proliferation.	Arginine	83-88	CD247 molecule	Homo sapiens	190-197
11950832-4	2002	The data presented here demonstrate that Jurkat T cells cultured in medium without L-Arg (L-Arg-free RPMI) have a rapid decrease in the expression of the T cell antigen receptor zeta chain (CD3zeta), the principal signal transduction element in this receptor, and a decrease in T cell proliferation.	Arginine	90-95	CD247 molecule	Homo sapiens	190-197
11950832-9	2002	Therefore, the regulation of L-Arg concentration in the microenvironment could represent an important mechanism to modulate the expression of CD3zeta and the T cell receptor and consequently of T cell function.	Arginine	29-34	CD247 molecule	Homo sapiens	142-149
12024015-3	2002	Repression occurs in the presence of arginine and requires the ArgR/Mcm1 complex that binds to two upstream arginine control (ARC) elements.	Arginine	37-45	transcription factor MCM1	Saccharomyces cerevisiae S288C	68-72
12024015-3	2002	Repression occurs in the presence of arginine and requires the ArgR/Mcm1 complex that binds to two upstream arginine control (ARC) elements.	Arginine	108-116	transcription factor MCM1	Saccharomyces cerevisiae S288C	68-72
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Arginine	180-188	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	72-76
12024017-2	2002	The transactivator Gcn4p is required for activation in minimal medium, while arginine repression requires the ArgR/Mcm1 regulatory complex, which binds to two upstream arginine control elements.	Arginine	77-85	transcription factor MCM1	Saccharomyces cerevisiae S288C	115-119
12024017-2	2002	The transactivator Gcn4p is required for activation in minimal medium, while arginine repression requires the ArgR/Mcm1 regulatory complex, which binds to two upstream arginine control elements.	Arginine	168-176	transcription factor MCM1	Saccharomyces cerevisiae S288C	115-119
11901152-5	2002	Among the 5 non-conserved residues within this segment, Arg-142 in human and Gln-142 in mouse ADA largely determined the capacity for stable binding to CD26 (Richard, E., Arredondo-Vega, F. X., Santisteban, I., Kelly, S. J., Patel, D. D., and Hershfield, M. S. (2000) J. Exp.	Arginine	56-59	dipeptidylpeptidase 4	Mus musculus	152-156
12009900-8	2002	Examination of various compounds with Ava in positions 9,10 and/or 14,15 revealed that the Leu(9)-Gly(10) and Arg(14)-Pro(15) segments of the disulfide ring are the principal structural elements determining hMCH-1R selectivity and ability to act as a hMCH-1R antagonist.	Arginine	110-113	melanin concentrating hormone receptor 1	Homo sapiens	207-214
11934690-6	2002	Other mutations at R589 also prevented the formation of the cell surface form of kAE1, indicating that this conserved arginine residue is important for proper trafficking.	Arginine	118-126	O-sialoglycoprotein endopeptidase	Homo sapiens	81-85
12007570-2	2002	C-terminally (Arg to Met) substituted analogs of the insect tachykinin-related peptide, Lom-TK I, displayed increased agonistic potencies in luminescent assays for human NK1 and NK2 receptors, whereas they showed reduced potencies in the STKR-assay.	Arginine	14-17	tachykinin receptor 1	Homo sapiens	170-173
11976690-5	2002	Key contacts are described between the GoLoco motif and Galpha protein, including the extension of GoLoco"s highly conserved Asp/Glu-Gln-Arg triad into the nucleotide-binding pocket of Galpha to make direct contact with the GDP alpha- and beta-phosphates.	Arginine	137-140	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	56-62
11976690-5	2002	Key contacts are described between the GoLoco motif and Galpha protein, including the extension of GoLoco"s highly conserved Asp/Glu-Gln-Arg triad into the nucleotide-binding pocket of Galpha to make direct contact with the GDP alpha- and beta-phosphates.	Arginine	137-140	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	185-191
11983426-11	2002	The enzyme also cleaved an N-terminal synthetic peptide of bovine annexin II (Gly(24)-Ser-Val-Lys-Ala-Tyr-Thr(30)-Asn-Phe-Asp-Ala-Glu(35)-Arg-Asp(37)) at a position between Asn(31) and Phe(32).	Arginine	138-141	annexin A2	Bos taurus	66-76
11904418-6	2002	We found that the Arg-719 --&gt; Trp (Arg719Trp) mutation, which is located in the converter domain of the myosin head fragment, causes an increase in force generation and fiber stiffness under isometric conditions by 48-59%.	Arginine	18-21	myosin heavy chain 14	Homo sapiens	107-113
11949887-1	2002	We have examined the functional significance of the naturally occurring mutation at position 64 of human beta3-adrenergic receptor (beta3AR), which changes the amino acid from tryptophan to arginine (W64R-beta3AR).	Arginine	190-198	adrenoceptor beta 3	Homo sapiens	105-130
11949887-1	2002	We have examined the functional significance of the naturally occurring mutation at position 64 of human beta3-adrenergic receptor (beta3AR), which changes the amino acid from tryptophan to arginine (W64R-beta3AR).	Arginine	190-198	adrenoceptor beta 3	Homo sapiens	132-139
11949887-1	2002	We have examined the functional significance of the naturally occurring mutation at position 64 of human beta3-adrenergic receptor (beta3AR), which changes the amino acid from tryptophan to arginine (W64R-beta3AR).	Arginine	190-198	adrenoceptor beta 3	Homo sapiens	205-212
12474524-11	2002	An individual possessing one allele of arginine form in p21 codon 31 has a higher risk of developing bladder cancer than the serine form.	Arginine	39-47	H3 histone pseudogene 16	Homo sapiens	56-59
11869205-0	2002	Epidermolysis bullosa simplex Dowling-Meara due to an arginine to cysteine substitution in exon 1 of keratin 14.	Arginine	54-62	keratin 14	Homo sapiens	101-111
11934254-9	2002	IGFBP-1 stimulation of EVT cell migration appears to occur by binding its Arg-Gly-Asp (RGD) domain to alpha5beta1 integrin, leading to phosphorylation of focal adhesion kinase (FAK) and MAPK (ERK-1 and ERK-2).	Arginine	74-77	insulin like growth factor binding protein 1	Homo sapiens	0-7
11939517-0	2002	Hb Siam [alpha15(A13)Gly--&gt;Arg (alpha1) (GGT--&gt;CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect.	Arginine	30-33	adrenoceptor alpha 1D	Homo sapiens	9-15
11773420-2	2002	An arginine-faced amphipathic alpha-helix in the E4orf6 protein is required for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa protein and to enhance replication of an E4 deletion virus.	Arginine	3-11	small nucleolar RNA, H/ACA box 73A	Homo sapiens	137-140
11773420-4	2002	Two of the six arginine residues within the alpha-helix, arginine-241 and arginine-243, were critical for directing nuclear localization of the E1B 55-kDa protein.	Arginine	15-23	small nucleolar RNA, H/ACA box 73A	Homo sapiens	144-147
11773420-4	2002	Two of the six arginine residues within the alpha-helix, arginine-241 and arginine-243, were critical for directing nuclear localization of the E1B 55-kDa protein.	Arginine	57-65	small nucleolar RNA, H/ACA box 73A	Homo sapiens	144-147
11773420-4	2002	Two of the six arginine residues within the alpha-helix, arginine-241 and arginine-243, were critical for directing nuclear localization of the E1B 55-kDa protein.	Arginine	57-65	small nucleolar RNA, H/ACA box 73A	Homo sapiens	144-147
11773420-5	2002	The four remaining arginine residues appear to provide a net positive charge for the E4orf6 protein to direct nuclear localization of the E1B 55-kDa protein.	Arginine	19-27	small nucleolar RNA, H/ACA box 73A	Homo sapiens	138-141
11773420-6	2002	The molecular determinants of the arginine-faced amphipathic alpha-helix that were required for the functional interaction between the E4orf6 and E1B 55-kDa proteins seen in the transfected cell differed from those required to support a productive infection.	Arginine	34-42	small nucleolar RNA, H/ACA box 73A	Homo sapiens	146-149
11839791-2	2002	We have used in vitro mutagenesis to obtain a temperature-sensitive SSO2 allele, sso2-1, in which a conserved arginine has been changed to a lysine.	Arginine	110-118	syntaxin	Saccharomyces cerevisiae S288C	68-72
11839791-2	2002	We have used in vitro mutagenesis to obtain a temperature-sensitive SSO2 allele, sso2-1, in which a conserved arginine has been changed to a lysine.	Arginine	110-118	syntaxin	Saccharomyces cerevisiae S288C	81-85
12017291-2	2002	MATERIALS AND METHODS: The aim of the present study was to evaluate the activity of CK II both in neoplastic and non-neoplastic human lung tissue by using a synthetic peptide with Arg-Arg-Arg-Asp-Asp-Asp-Ser-Asp-Asp-Asp (RRRDDDSDDD) sequence.	Arginine	180-183	casein kinase 2 alpha 1	Homo sapiens	84-89
12112002-5	2002	L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.	Arginine	0-10	heme oxygenase 1	Homo sapiens	109-113
12112002-5	2002	L-Arginine analogs N-nitro-L-arginine methyl ester (L-NAME) and N-nitro-L-arginine (NLA) significantly block HO-1 protein induced by LPS/IFN-gamma associated with a decrease in NO (not PGE(2)) production.	Arginine	0-10	interferon regulatory factor 6	Homo sapiens	133-136
11862322-7	2002	Interestingly, using the OGTT index, insulin sensitivity was significantly greater in X/Ala (PPARgamma2) + X/Arg (IRS-1) than in Pro/Pro (PPARgamma2) + X/Arg (IRS-1).	Arginine	109-112	insulin receptor substrate 1	Homo sapiens	114-119
11738935-3	2001	In the present study, sequence analysis of Xrcc4 cDNA in M10 cells disclosed a transversion of A (370) to T, which results in a change of arginine (124) to a termination codon.	Arginine	138-146	X-ray repair complementing defective repair in Chinese hamster cells 4	Mus musculus	43-48
11741585-0	2001	Domain IVa of laminin alpha5 chain is cell-adhesive and binds beta1 and alphaVbeta3 integrins through Arg-Gly-Asp.	Arginine	102-105	hemoglobin, beta adult major chain	Mus musculus	62-83
11791622-2	2001	The two amyloid proteins, ABri and ADan, are degradation products of the same precursor molecule BriPP bearing different genetic defects, namely a Stop-to-Arg mutation in FBD and a ten-nucleotide duplication-insertion immediately before the stop codon in FDD.	Arginine	155-158	integral membrane protein 2B	Homo sapiens	26-30
11789781-7	2001	RESULTS: Before heart excision, serum cardiac troponin I concentrations were higher in the L-arginine than in the control group (0.037 +/- 0.01 versus 0.02 +/- 0.05 microg x L(-1); p &lt; 0.05).	Arginine	91-101	troponin I3, cardiac type	Rattus norvegicus	38-56
11789781-8	2001	During reperfusion, cardiac troponin I release was lower in the L-arginine than in the control group (0.04 +/- 0.01 versus 0.19 +/- 0.03 ng x min(-1); p &lt; 0.05).	Arginine	64-74	troponin I3, cardiac type	Rattus norvegicus	20-38
11730482-2	2001	A pentapeptide, Gly-Arg-Arg-Arg-Arg, corresponding to a region of the N-terminal portion of human Lf rich in basic amino acids, was synthesized and its intracellular localization was investigated.	Arginine	20-23	HLF transcription factor, PAR bZIP family member	Homo sapiens	98-100
11730482-2	2001	A pentapeptide, Gly-Arg-Arg-Arg-Arg, corresponding to a region of the N-terminal portion of human Lf rich in basic amino acids, was synthesized and its intracellular localization was investigated.	Arginine	24-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	98-100
11730482-2	2001	A pentapeptide, Gly-Arg-Arg-Arg-Arg, corresponding to a region of the N-terminal portion of human Lf rich in basic amino acids, was synthesized and its intracellular localization was investigated.	Arginine	24-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	98-100
11730482-2	2001	A pentapeptide, Gly-Arg-Arg-Arg-Arg, corresponding to a region of the N-terminal portion of human Lf rich in basic amino acids, was synthesized and its intracellular localization was investigated.	Arginine	24-27	HLF transcription factor, PAR bZIP family member	Homo sapiens	98-100
11557758-4	2001	Patients with FBD have a single nucleotide substitution at codon 267 in the BRI2 gene, resulting in an arginine replacing the stop codon and a longer open reading frame of 277 amino acids instead of 266.	Arginine	103-111	integral membrane protein 2B	Homo sapiens	76-80
11720436-4	2001	MC1R Arg(160)/Arg(160) homozygotes were at increased risk (P = 0.027, odds ratio = 1.94) while TYR A2/A2 homozygotes were at reduced risk of prostate cancer (P = 0.033, odds ratio = 0.48).	Arginine	5-8	melanocortin 1 receptor	Homo sapiens	0-4
11707620-7	2001	The substrate specificity of SGK isoforms superficially resembles that of PKB in that serine and threonine residues lying in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr sequences (where Xaa is a variable amino acid) are phosphorylated.	Arginine	125-128	protein tyrosine kinase 2 beta	Homo sapiens	74-77
11707620-7	2001	The substrate specificity of SGK isoforms superficially resembles that of PKB in that serine and threonine residues lying in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr sequences (where Xaa is a variable amino acid) are phosphorylated.	Arginine	133-136	protein tyrosine kinase 2 beta	Homo sapiens	74-77
11668192-5	2001	Measurable levels of Met-enkephalin-Arg-Phe and nociceptin/orphanin FQ were found in tendon tissue using RIA, whereas dynorphin B could not be detected.	Arginine	36-39	proenkephalin	Rattus norvegicus	25-35
11602698-9	2001	An arginine residue at position 73 in VRA was found to be important for envelope binding to feline Pit2 but not feline Pit1.	Arginine	3-11	solute carrier family 20 member 2	Homo sapiens	99-103
11601995-4	2001	Seven site-specific point mutants of MDP-1 were produced by modifying the catalytic aspartate, serine, and lysine residues to asparagine or glutamate, alanine, and arginine, respectively.	Arginine	164-172	magnesium dependent phosphatase 1	Homo sapiens	37-42
11683584-6	2001	To identify the cytokine region defined by mAbs, hG-CSF was digested with different proteolytic enzymes: Arg-C, Glu-C, trypsin and alpha chymotrypsin.	Arginine	105-108	colony stimulating factor 3	Homo sapiens	49-55
11583577-1	2001	The side chain of residue Arg(238) in morphinone reductase (MR) is located close to the N-1/C-2 carbonyl region of the flavin isoalloxazine ring.	Arginine	26-29	complement C2	Homo sapiens	92-95
11564694-4	2001	Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands.	Arginine	83-91	solute carrier family 3 member 2	Homo sapiens	19-22
11564694-4	2001	Injection of human 4F2 heavy chain cRNA alone stimulated the uptake of leucine and arginine due to dimerization of human 4F2 heavy chain with an endogenous Xenopus light chain, but did not affect the uptake of other ligands.	Arginine	83-91	solute carrier family 3 member 2	Homo sapiens	121-124
11723742-4	2001	The cell-binding domain obtained from fibronectin included the Arg-Gly-Asp (RGD) sequence.	Arginine	63-66	fibronectin 1	Mus musculus	38-49
11684018-3	2001	A chronic granulomatous disease (CGD)-associated mutation in the p47(phox) PX domain that abrogates PtdIns(3)P binding maps to a conserved Arg that does not directly interact with the phosphoinositide but instead appears to stabilize a critical lipid binding loop.	Arginine	139-142	pleckstrin	Homo sapiens	65-74
11592045-7	2001	CONCLUSION: The children with beta3-AR Trp/Arg mutation may become obese because of the low energy metabolism; less active and exercise may increase the risk of obesity.	Arginine	43-46	adrenoceptor beta 3	Homo sapiens	30-38
11601910-5	2001	Umbraviral ORF3 proteins contain a conserved arginine-rich domain, and the possible roles of this motif in the functions of the proteins are discussed.	Arginine	45-53	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	11-15
11779025-6	2001	The GABA uptake inhibitor 4,5,6,7,-tetrahydroisoxazolo[4,5-c]-pyridin-3-ol hydrobromide (THPO) (300 microM) not only mimicked but also occluded the ability of L-arginine (3 mM) to potentiate currents evoked by isoguvacine.	Arginine	159-169	thrombopoietin like 1	Rattus norvegicus	89-93
11575928-6	2001	This alteration might allow MMP-12 to accept P1" Arg residues, making it unique among MMPs.	Arginine	49-52	matrix metallopeptidase 7	Homo sapiens	86-90
11445562-8	2001	SNARE complexes to which Ykt6p contributed a fourth glutamine residue in the 0 layer were nonfunctional, suggesting an essential function for arginine in the 0 layer of these complexes.	Arginine	142-150	palmitoyltransferase YKT6	Saccharomyces cerevisiae S288C	25-30
11517171-5	2001	Interestingly, a single mutation at the corresponding positions of Arg339 or Arg342 responded as the wild-type human secretin receptor in all functional assays, indicating that the presence of one Arg at either position within the RLAR motif is sufficient for a normal receptor function.	Arginine	67-70	secretin receptor	Homo sapiens	117-134
11502871-0	2001	Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability.	Arginine	13-23	natriuretic peptide type A	Mus musculus	50-76
11502871-4	2001	PURPOSE: To investigate whether ANP exerts an effect on LPS-induced L-arginine uptake.	Arginine	68-78	natriuretic peptide type A	Mus musculus	32-35
11749852-2	2001	METHODS: The influence of L-arg on the cell proliferation was determined by MTT assay, immunocytochemical detection of expression of proliferative cell nuclear antigen (PCNA), and flow cytometrical analysis of cell cycle.	Arginine	26-31	proliferating cell nuclear antigen	Homo sapiens	169-173
11749852-5	2001	Immunocytochemical study for PCNA showed the number of cells was decreased, though the percentage of PCNA positive cells was increased in L-arg-treated group.	Arginine	138-143	proliferating cell nuclear antigen	Homo sapiens	29-33
11749852-5	2001	Immunocytochemical study for PCNA showed the number of cells was decreased, though the percentage of PCNA positive cells was increased in L-arg-treated group.	Arginine	138-143	proliferating cell nuclear antigen	Homo sapiens	101-105
11435563-5	2001	Here we show that an arginine at position 73 within variable region A (VRA) of the FeLV-B envelope surface unit (SU) is necessary for viral entry into cells via the human Pit2 receptor.	Arginine	21-29	solute carrier family 20 member 2	Homo sapiens	171-175
11479422-4	2001	As the pivotal residues around the most predominant R24C activating CDK4 mutation are invariant between CDK2 and CDK4, we speculated that the pivotal arginine (position 22 in CDK2), or a nearby residue, may be mutated in some melanomas, resulting in the diminution of its binding and inhibition by p27KIP1 or p21CIP1.	Arginine	150-158	cyclin dependent kinase inhibitor 1B	Homo sapiens	298-305
11438644-2	2001	Alanine scanning mutagenesis of the Cy motif of the cdk inhibitor p21 revealed that the conserved arginine or leucine (constituting the conserved RXL sequence) was important for p21"s ability to inhibit cyclin E-cdk2 activity.	Arginine	98-106	proliferating cell nuclear antigen	Homo sapiens	203-209
11467954-3	2001	The regions responsible for this poor binding are known to be Arg(45) in hEGF and the L2 domain in the chicken EGFR.	Arginine	62-65	epidermal growth factor receptor	Gallus gallus	111-115
11313365-0	2001	Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.	Arginine	140-148	protein tyrosine kinase 2 beta	Homo sapiens	14-30
11306565-6	2001	We found that Arg(838) within the dimerization domain establishes the Ca(2+) sensitivity of RetGC-1 by determining the strength of the coiled-coil interaction.	Arginine	14-17	guanylate cyclase 2D, retinal	Homo sapiens	92-99
11306565-10	2001	Consistent with the characteristics of this disease, the Arg(838)-substituted RetGC-1 mutants exhibit a dominant biochemical phenotype.	Arginine	57-60	guanylate cyclase 2D, retinal	Homo sapiens	78-85
11313338-1	2001	The recent crystal structure of Pin1 protein bound to a doubly phosphorylated peptide from the C-terminal domain of RNA polymerase II revealed that binding interactions between Pin1 and its substrate take place through its Trp-Trp (WW) domain at the level of the loop Ser(11)-Arg(12) and the aromatic pair Tyr(18)-Trp(29), and showed a trans conformation for both pSer-Pro peptide bonds.	Arginine	276-279	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-36
11313338-1	2001	The recent crystal structure of Pin1 protein bound to a doubly phosphorylated peptide from the C-terminal domain of RNA polymerase II revealed that binding interactions between Pin1 and its substrate take place through its Trp-Trp (WW) domain at the level of the loop Ser(11)-Arg(12) and the aromatic pair Tyr(18)-Trp(29), and showed a trans conformation for both pSer-Pro peptide bonds.	Arginine	276-279	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	177-181
11494128-4	2001	Two-hybrid screens identified regions of Abl and Arg that bind to the EphB2 and EphA4 receptors, suggesting a novel signaling connection involving the two kinase families.	Arginine	49-52	EPH receptor B2	Homo sapiens	70-75
11494128-5	2001	The association of full-length Abl and Arg with EphB2 was confirmed by co-immunoprecipitation and found to involve several distinct protein interactions.	Arginine	39-42	EPH receptor B2	Homo sapiens	48-53
11494128-6	2001	The SH2 domains of Abl and Arg bind to tyrosine-phosphorylated motifs in the juxtamembrane region of EphB2.	Arginine	27-30	EPH receptor B2	Homo sapiens	101-106
11406294-7	2001	These results strongly suggest that both arginine transport by CAT-2 and citrulline-arginine recycling are important for high-output production of NO in activated microglial cells.	Arginine	41-49	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	63-68
11389017-4	2001	The antibody-bound prothrombin formed a stable stoichiometric complex with antithrombin III, consisting of intact prothrombin and an antithrombin III molecule cleaved at the (393)Arg-(394)Ser bond.	Arginine	179-182	serpin family C member 1	Homo sapiens	75-91
11389017-4	2001	The antibody-bound prothrombin formed a stable stoichiometric complex with antithrombin III, consisting of intact prothrombin and an antithrombin III molecule cleaved at the (393)Arg-(394)Ser bond.	Arginine	179-182	serpin family C member 1	Homo sapiens	133-149
11419962-6	2001	The l -arginine pretreatment attenuated the increases in iNOS and MPO activities and nitrite/nitrate concentration and the decrease in cNOS activity in the gastric mucosal tissue in a dose-dependent manner, while the d -arginine pretreatment did not.	Arginine	4-15	myeloperoxidase	Rattus norvegicus	66-69
11352754-12	2001	These data suggest a revised hypothesis for the mechanism of SHU9119 antagonism at the MC4R which may be attributed to the presence of a "bulky" naphthyl moiety at the 7 position (original hypothesis), and additionally that both the stereochemistry and naphthyl ring position (2" versus 1") are important for positioning of the ligand Arg(8) residue with the corresponding mMC4R amino acids.	Arginine	335-338	melanocortin 4 receptor	Mus musculus	87-91
11331016-0	2001	Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.	Arginine	0-8	solute carrier family 22 member 8	Rattus norvegicus	102-107
11331016-9	2001	These data indicate that arginine 454 and lysine 370 are essential for the anion specificity of rOAT3.	Arginine	25-33	solute carrier family 22 member 8	Rattus norvegicus	96-101
11316186-8	2001	A homozygous missense mutation (CGG-to-TGG) at RET codon 969 was identified in this patient, which resulted in an amino acid change from arginine to tryptophan.	Arginine	137-145	ret proto-oncogene	Homo sapiens	47-50
11277929-5	2001	The mature SPI 1 (6056.7 Da, 56 residues) is a typical thermostable Kunitz-type proteinase inhibitor with Arg in P1 position.	Arginine	106-109	Spi-1 proto-oncogene	Homo sapiens	11-16
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Arginine	22-25	protocadherin alpha subfamily C, 1	Mus musculus	0-5
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Arginine	22-25	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	74-77
11159022-4	2001	We hypothesized that L-Arg would attenuate the production of lung chemokines by stabilizing IkappaB-alpha and preventing NF-kappaB DNA binding.	Arginine	21-26	NFKB inhibitor alpha	Rattus norvegicus	92-105
11159022-8	2001	L-Arg attenuated the production of chemokine protein and mRNA, prevented the decrease in IkappaB-alpha levels, and inhibited NF-kappaB DNA binding.	Arginine	0-5	NFKB inhibitor alpha	Rattus norvegicus	89-102
11171599-0	2001	Selective amylin inhibition of the glucagon response to arginine is extrinsic to the pancreas.	Arginine	56-64	islet amyloid polypeptide	Rattus norvegicus	10-16
11171599-9	2001	Amylin inhibited arginine-induced, but not hypoglycemia-induced, glucagon secretion in the same animal.	Arginine	17-25	islet amyloid polypeptide	Rattus norvegicus	0-6
11300497-0	2001	L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells.	Arginine	0-10	CD247 molecule	Homo sapiens	43-69
11300497-0	2001	L-Arginine regulates the expression of the T-cell receptor zeta chain (CD3zeta) in Jurkat cells.	Arginine	0-10	CD247 molecule	Homo sapiens	71-78
11300497-6	2001	When the helper T-cell line Jurkat was cultured in arginine-free medium, there was a preferential decrease in the expression of the TCR zeta chain (CD3zeta).	Arginine	51-59	CD247 molecule	Homo sapiens	132-146
11300497-6	2001	When the helper T-cell line Jurkat was cultured in arginine-free medium, there was a preferential decrease in the expression of the TCR zeta chain (CD3zeta).	Arginine	51-59	CD247 molecule	Homo sapiens	148-155
11300497-7	2001	The reduced expression of CD3zeta was observed within 24 h of culture in L-arginine-free medium and was completely reversed with the replenishment of L-arginine.	Arginine	73-83	CD247 molecule	Homo sapiens	26-33
11300497-7	2001	The reduced expression of CD3zeta was observed within 24 h of culture in L-arginine-free medium and was completely reversed with the replenishment of L-arginine.	Arginine	150-160	CD247 molecule	Homo sapiens	26-33
11179314-9	2001	Together, hLF and peptides derived from its N terminus are highly effective against infections with antibiotic-resistant S. aureus and K. pneumoniae, and the first two arginines play an essential role in this activity.	Arginine	168-177	HLF transcription factor, PAR bZIP family member	Homo sapiens	10-13
11238478-6	2001	The patient had a homozygous duplication of six nucleotides at codon 143 in exon 3 of CYP11B2, leading to the insertion of two amino acid residues (Arg-Leu).	Arginine	148-151	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	86-93
11273651-3	2001	Using the native mGluR1 and CD2-mGluR1 chimeric molecules, as well as their C-terminal truncations and mutants, we identified an endoplasmic reticulum (ER) retention signal Arg-Arg-Lys-Lys within the C-terminal sequence of mGluR1b.	Arginine	173-176	CD2 molecule	Homo sapiens	28-31
11226234-2	2001	Experiments with a double mutant and structural homology with the P22 Arc repressor suggest that contacts made by Arg-28 and stabilized by Glu-33 are largely responsible for dimer-dimer cooperativity in Mnt.	Arginine	114-117	Mnt	Salmonella phage P22	203-206
11258432-8	2001	Myeloperoxidase increased by L-NAME and this effect was reverted by the addition of L-arginine, whereas no change was observed with spermine NONOate.	Arginine	84-94	myeloperoxidase	Rattus norvegicus	0-15
11354794-8	2001	It was found that L-arginine significantly inhibited the increase of MABP and LVW/BW, attenuated the activity of MAPK, increased protein expression of eNOS and MKP-1 and potentiated production of NO in cardiac tissue with the most effective dosage of 150 mg/kg, and these effects of L-arginine could be inhibited by L-NAME.	Arginine	18-28	dual specificity phosphatase 1	Rattus norvegicus	160-165
11354794-10	2001	The anti-hypertrophic effects of L-arginine may involve increase of eNOS protein expression and NO production, potentiation of MKP-1 protein expression, and inhibition of MAPK activity in the cardiac tissue of RHR.	Arginine	33-43	dual specificity phosphatase 1	Rattus norvegicus	127-132
11152972-7	2001	Mutations of K-ras, analyzed by single-strand conformation polymorphism and sequencing, were, in codon 12, wild type GGT (glycine), to GAT (aspartic acid); to GTT (valine); and to CGT (arginine); and in codon 61, wild-type CAA (glutamine), to CGA (arginine).	Arginine	185-193	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-18
11152972-7	2001	Mutations of K-ras, analyzed by single-strand conformation polymorphism and sequencing, were, in codon 12, wild type GGT (glycine), to GAT (aspartic acid); to GTT (valine); and to CGT (arginine); and in codon 61, wild-type CAA (glutamine), to CGA (arginine).	Arginine	248-256	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-18
11141496-7	2001	DNA sequence analysis of exons 2 to 9 of the neuroserpin gene in the proband showed the published normal neuroserpin sequence except for the presence of both adenine and cytosine at the first position of codon 52, that indicates heterozygosity for both the normal Ser(AGT) and variant Arg(CGT) at this position in the expressed protein.	Arginine	285-288	serpin family I member 1	Homo sapiens	45-56
11235919-5	2001	Results indicate that the two residues do not interact specifically with each other; however, residue 13 (Arg) is likely to be involved in interactions between cytochrome c and other electrostatically oriented physiological partners (intermolecular), whereas residue 90 (Asp) is involved in maintaining the intrinsic structure and stability of cytochrome c (intramolecular).	Arginine	106-109	cytochrome c, somatic	Equus caballus	160-172
11168027-3	2001	Other lipid and nonlipid risk factors including a Ser to Arg (S128R) substitution in the E-selectin gene were also assessed.	Arginine	57-60	selectin E	Homo sapiens	89-99
11436200-0	2001	p21 gene codon 31 arginine/serine polymorphism: non-association with endometriosis.	Arginine	18-26	H3 histone pseudogene 16	Homo sapiens	0-3
11436200-4	2001	The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg).	Arginine	122-130	H3 histone pseudogene 16	Homo sapiens	26-29
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Arginine	72-75	scavenger receptor class B member 2	Homo sapiens	0-6
10973972-4	2000	LIMPII and GLUT4 display negatively (Asp(470)/Glu(471)) and positively (Arg(484)/Arg(485)) charged residues, respectively, at positions -4 and -5 upstream from the critical Leu residue.	Arginine	81-84	scavenger receptor class B member 2	Homo sapiens	0-6
11188692-3	2000	Mutagenesis studies, however, have shown that the arginine can only partially account for the 10(5)-fold increase in the GAP-accelerated GTPase rate of p21.	Arginine	50-58	H3 histone pseudogene 16	Homo sapiens	152-155
11108845-3	2000	The cytoplasmic domain of plexins shows sequence similarity to GTPase activating proteins (GAPs) and mutation of two arginines that correspond to the catalytic residues of Ras GAPs inactivates plexin-A1.	Arginine	117-126	plexin A1	Homo sapiens	193-202
11099312-3	2000	All three TCR exhibited N-nucleotide-determined Arg-Asp motifs in their CDR3-ss sequences.	Arginine	48-51	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	10-13
11099312-8	2000	Hence, in these two TCR the Arg-Asp motif is clearly involved in contacting Ni-MHC complexes, and close cooperation between alpha and ss chain is required.	Arginine	28-31	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	20-23
11099312-9	2000	In contrast, the third TCR retained Ni reactivity upon mutation of alpha chain position 51 or of its ss chain Arg-Asp motif, which rather affected the pattern of DR cross-restriction.	Arginine	110-113	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	23-26
11095648-2	2000	Agmatine, decarboxylated arginine, has been shown in vitro to suppress both inducible nitric oxide synthase and the rate-limiting enzyme of polyamine biosynthesis, ornithine decarboxylase (ODC).	Arginine	25-33	ornithine decarboxylase 1	Rattus norvegicus	164-187
11095648-2	2000	Agmatine, decarboxylated arginine, has been shown in vitro to suppress both inducible nitric oxide synthase and the rate-limiting enzyme of polyamine biosynthesis, ornithine decarboxylase (ODC).	Arginine	25-33	ornithine decarboxylase 1	Rattus norvegicus	189-192
11150639-7	2000	Antagonists to the mammalian B(2) receptor generally contain a D-aromatic amino acid at position 7 of BK but the analog [Arg(0),Trp(5),D-Phe(7),Leu(8)]-BK was a weak agonist at the trout receptor.	Arginine	121-124	bradykinin receptor B2	Homo sapiens	29-42
11042131-1	2000	NRD convertase (N-arginine dibasic convertase, NRD-C) is a dibasic selective metalloprotease which cleaves on the N-terminal side of an arginine residue in a dibasic pair.	Arginine	18-26	nardilysin convertase	Rattus norvegicus	0-14
11042131-1	2000	NRD convertase (N-arginine dibasic convertase, NRD-C) is a dibasic selective metalloprotease which cleaves on the N-terminal side of an arginine residue in a dibasic pair.	Arginine	18-26	nardilysin convertase	Rattus norvegicus	47-52
10896665-0	2000	Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.	Arginine	81-89	TRAMP complex RNA-binding subunit	Saccharomyces cerevisiae S288C	28-33
10896665-0	2000	Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.	Arginine	81-89	TRAMP complex RNA-binding subunit	Saccharomyces cerevisiae S288C	38-43
10896665-0	2000	Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.	Arginine	81-89	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	59-64
10896665-10	2000	Thus, Air1p and Air2p may affect mRNA transport by regulating the arginine methylation state of heterogeneous nuclear ribonucleoproteins.	Arginine	66-74	TRAMP complex RNA-binding subunit	Saccharomyces cerevisiae S288C	6-11
10896665-10	2000	Thus, Air1p and Air2p may affect mRNA transport by regulating the arginine methylation state of heterogeneous nuclear ribonucleoproteins.	Arginine	66-74	TRAMP complex RNA-binding subunit	Saccharomyces cerevisiae S288C	16-21
11866936-8	2000	Some p53 variants such as 172 Arg--&gt;Leu can still retain the tumor suppression function of the wild-type.	Arginine	30-33	transformation related protein 53, pseudogene	Mus musculus	5-8
10993737-3	2000	A single nucleotide change, resulting in a Cys to Tyr substitution at position 599 of arginyl-tRNA synthetase, is responsible for the defective phenotype of the thermosensitive and arginine hyper-auxotroph Arg-1 cell line.	Arginine	181-189	argininosuccinate synthase	Saccharomyces cerevisiae S288C	206-211
10887182-6	2000	This protein, which we have termed IHABP4, was also found to be an intracellular and a specific hyaluronan-binding protein, containing several hyaluronan-binding motifs: (R/K)[X(7)](R/K) (where R/K denotes arginine or lysine and X denotes non-acidic amino acids).	Arginine	206-214	hyaluronic acid binding protein 4	Mus musculus	35-41
11008988-11	2000	MEASUREMENTS AND MAIN RESULTS: The increased concentrations of plasma glutathione S-transferase observed in vehicle-treated hemorrhage animals were normalized with L-arginine treatment at 5 hrs after resuscitation.	Arginine	164-174	hematopoietic prostaglandin D synthase	Rattus norvegicus	70-95
10972671-3	2000	We have shown activation of Jun N-terminal kinase/stress-activated protein kinase (SAPK) and p42/44 mitogen-activated protein kinase (MAPK) in stretched MCs and have also demonstrated that L-arginine decreases resident cell proliferation and protects against glomerulosclerosis in remnant kidney glomeruli, presumably by increasing nitric oxide (NO) production.	Arginine	189-199	cyclin dependent kinase 20	Homo sapiens	93-96
10964656-3	2000	We constructed stable clones of C6 cells transfected with two types of IkappaBalpha mutant genes (IkappaBalpha(SS --&gt; AA); Ser-32/36 to Ala-32/36, IkappaBalpha(KK --&gt; RR); Lys-21/22 to Arg-21/22).	Arginine	191-194	NFKB inhibitor alpha	Rattus norvegicus	71-83
10846180-6	2000	Accordingly, by site-directed mutagenesis of 22 amino acid positions spread out on all faces of the ICAM-4 molecule, we identified four exposed residues, Leu(80), Trp(93), and Arg(97) on the CFG face and Trp(77) on the E-F loop of domain D1 that may contact LFA-1 as part of the binding site.	Arginine	176-179	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	100-106
10851237-6	2000	Furthermore, the carboxyl-terminal arginine- and glycine-rich domain of Lsm4 directly interacts with SMN.	Arginine	35-43	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	72-76
10933889-6	2000	However, in RARalpha and RARgamma this Ser appears to play a small role in conjunction with Arg(276) and Arg(278), respectively, for these activities.	Arginine	92-95	retinoic acid receptor alpha	Homo sapiens	12-20
10933889-6	2000	However, in RARalpha and RARgamma this Ser appears to play a small role in conjunction with Arg(276) and Arg(278), respectively, for these activities.	Arginine	105-108	retinoic acid receptor alpha	Homo sapiens	12-20
10919983-11	2000	Inhibitors of NOS, sGC, and PKG can block the stimulant effect of L-Arg on CBF.	Arginine	66-71	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	19-22
10903143-9	2000	In addition to its unique ligand binding properties, HSA also possesses an esterase-like activity, and studies with p-nitrophenyl acetate as a substrate showed that, although Arg-410 is important, the enzymic activity of HSA is much more dependent on the presence of Tyr-411.	Arginine	175-178	CD24 molecule	Rattus norvegicus	53-56
11003134-3	2000	These analogues were designed looking for suppressors of EAE induced by guinea pig MBP(72-85) epitope (Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-Pro-Val) in Lewis rats.	Arginine	119-122	myelin basic protein	Cavia porcellus	83-86
10908322-1	2000	We have investigated the effect of single amino acid substitutions of conserved arginines on the catalytic activities of the human Ogg1 protein (alpha-hOgg1-Ser(326)) (wild-type alpha-hOgg1).	Arginine	80-89	8-oxoguanine DNA glycosylase	Homo sapiens	131-135
10908322-2	2000	Mutant forms of hOgg1 with mutations Arg(46)--&gt;Gln (alpha-hOgg1-Gln(46)) and Arg(154)--&gt;His (alpha-hOgg1-His(154)) have previously been identified in human tumors.	Arginine	37-40	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
10908322-2	2000	Mutant forms of hOgg1 with mutations Arg(46)--&gt;Gln (alpha-hOgg1-Gln(46)) and Arg(154)--&gt;His (alpha-hOgg1-His(154)) have previously been identified in human tumors.	Arginine	80-83	8-oxoguanine DNA glycosylase	Homo sapiens	16-21
10908322-14	2000	The substitution of Arg(154), in addition to diminishing the activity on 8-OH-Gua, relaxes the selectivity found in the wild-type alpha-hOgg1 for the base opposite 8-OH-Gua.	Arginine	20-23	8-oxoguanine DNA glycosylase	Homo sapiens	136-141
10777496-5	2000	During the exposure of activated T cells to NAD, the CD38 is modified by ecto-mono-ADP-ribosyltransferases (ecto-mono-ADPRTs) specific for cysteine and arginine residues.	Arginine	152-160	CD38 molecule	Homo sapiens	53-57
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Arginine	22-31	low density lipoprotein receptor	Homo sapiens	138-170
10884290-2	2000	Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR).	Arginine	22-31	low density lipoprotein receptor	Homo sapiens	172-176
10856234-3	2000	In this study, we report SH3 domain binding to a novel proline-independent motif in immune cell adaptor SKAP55, which is comprised of two N-terminal lysine and arginine residues followed by two tyrosines (i.e. RKxxYxxY).	Arginine	160-168	src kinase associated phosphoprotein 1	Homo sapiens	104-110
10844139-2	2000	In isolated smooth muscle cells, the maximal relaxant effect of VIP (10(-9) M) was inhibited by 94% by the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine (L-NA, 10(-4) M) and by 85% by the inducible NOS (iNOS)-selective inhibitor N-(3-(aminomethyl)-benzyl)acetamide (1400W; 10(-6) M).	Arginine	146-156	vasoactive intestinal peptide	Sus scrofa	64-67
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Arginine	4-12	serpin family B member 3	Homo sapiens	188-191
10850407-2	2000	The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon.	Arginine	222-230	serpin family B member 3	Homo sapiens	188-191
10799524-8	2000	From deletion studies, a region adjacent to the arginine patch ((288)EYV(290) on BNIP-2) and the Switch I and Rho family-specific "Insert" region on Cdc42 are involved in the binding.	Arginine	48-56	BCL2 interacting protein 2	Homo sapiens	81-87
10799524-9	2000	The results indicate that the BCH domain of BNIP-2 represents a novel GAP domain that employs an arginine patch motif similar to that of the Cdc42-homodimer.	Arginine	97-105	BCL2 interacting protein 2	Homo sapiens	44-50
10835495-7	2000	Similar mutation analysis of hBUBR1 in 47 lung cancer cell line cDNAs revealed a frequent polymorphism at codon 349 (CAA to CGA) leading to a substitution of Gln to Arg but no mutations.	Arginine	165-168	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	29-35
10772937-0	2000	Arginines 97 and 108 in CYP2C9 are important determinants of the catalytic function.	Arginine	0-9	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
10727611-4	2000	However, modification of the LH receptor by substitution of Lys583--&gt;Arg (LHR-K583R) results in a receptor that is non-functional and which has a significantly shorter rotational correlation time of 130+/-12 micros following binding of hCG.	Arginine	72-75	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	77-80
10715562-7	2000	The result indicates that chronic AAS treatment increased the activity in the dynorphin B- and Met-enkephalin-Arg(6)Phe(7)-ir in the hypothalamus, striatum and periaqueductal gray (PAG) compared to controls.	Arginine	110-113	proenkephalin	Rattus norvegicus	99-109
10699990-3	2000	The role of Ki-ras activation (a G--&gt;C transversion in codon 12, arginine for glycine) in the cell cycle and apoptosis was investigated using control and permanently transfected NIH3T3 mouse fibroblasts.	Arginine	68-76	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	12-18
10842928-8	2000	Moreover this study is to the best of our knowledge the first to report that the distal hinge region of the reactive site loop (Arg 356) may be involved in the substrate behaviour of PAI-1.	Arginine	128-131	serpin family E member 1	Homo sapiens	183-188
10772188-7	2000	The production of IFN-gamma by splenic lymphocytes treated with Con A was suppressed in the arginine group (p &lt; .05).	Arginine	92-100	interferon gamma	Rattus norvegicus	18-27
10660623-0	2000	Selective activation of MAPK(erk1/2) by laminin-1 peptide alpha1:Ser(2091)-Arg(2108) regulates macrophage degradative phenotype.	Arginine	75-78	adrenoceptor alpha 1D	Homo sapiens	58-64
10739384-4	2000	Bovine PCI has a putative reactive site peptide bond, Lys-Ser, that is different from the reactive site sequence (Arg-Ser) of other species" PCI.	Arginine	114-117	serpin family A member 5	Bos taurus	7-10
11094435-3	2000	The conversion of protein-contained arginine to citrulline is an enzymatic process that is carried out by peptidylarginine deiminase (PAD), an enzyme that appears to be hormonally controlled.	Arginine	36-44	peptidyl arginine deiminase 4	Homo sapiens	106-132
11094435-3	2000	The conversion of protein-contained arginine to citrulline is an enzymatic process that is carried out by peptidylarginine deiminase (PAD), an enzyme that appears to be hormonally controlled.	Arginine	36-44	peptidyl arginine deiminase 4	Homo sapiens	134-137
11211158-3	2000	The synthetic peptide Cys-Gly-(Arg-Gly-Asp)-Ser-Pro-Lys, containing the cell-adhesive region of fibronectin (RGD), has been grafted to the polymer substrate via the cysteine residue using a procedure recently developed in the authors laboratory.	Arginine	30-34	fibronectin 1	Rattus norvegicus	96-107
16232702-2	2000	This proteolytic cleavage was inhibited significantly by the addition of high concentrations of l-arginine and l-lysine, with a resultant marked improvement in the yield of intact hLC1.	Arginine	96-106	NADH:ubiquinone oxidoreductase subunit C2	Homo sapiens	180-184
11021404-0	2000	Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N. Carboxypeptidase R (EC 3.4.17.20) (CPR) and carboxypeptidase N (EC 3.4.17.3) (CPN) cleave carboxy-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.	Arginine	207-215	carboxypeptidase B2	Rattus norvegicus	100-118
10632874-1	2000	Regulation of arginine metabolism requires the integrity of four regulatory proteins, ArgRI, ArgRII, ArgRIII and Mcm1.	Arginine	14-22	transcription factor MCM1	Saccharomyces cerevisiae S288C	113-117
10632874-7	2000	We show that the impairment of arginine regulation in an argRIII deletant strain is a result of a lack of stability of ArgRI and Mcm1.	Arginine	31-39	transcription factor MCM1	Saccharomyces cerevisiae S288C	129-133
10574940-7	1999	Treatment of mitochondrial GPAT with arginine-modifying agents, phenylglyoxal and cyclohexanedione, inactivated the enzyme.	Arginine	37-45	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	27-31
10574940-12	1999	Moreover, R278K mitochondrial GPAT still showed sensitivity to arginine-modifying agents, as in the case of wild-type mitochondrial GPAT.	Arginine	63-71	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	30-34
10574940-13	1999	These results suggest that Arg-318 may be critical for mitochondrial GPAT activity, whereas Arg-278 can be replaced by a basic amino acid.	Arginine	27-30	glycerol-3-phosphate acyltransferase, mitochondrial	Mus musculus	69-73
10570058-1	1999	The inhibition of nitric oxide synthase by N-nitro-L-arginine methyl ester (0.03-3 mM) dose-dependently reduced nitric oxide (NO(*)) levels and enhanced the outward currents carried by human ether-a-gogo-related gene-1 (hERG1) K(+) channels expressed in Xenopus laevis oocytes, whereas the increase in NO(*) levels achieved by exposure to L-arginine (0.03-10 mM) inhibited these currents.	Arginine	51-61	potassium voltage-gated channel subfamily H member 2	Homo sapiens	220-225
10570058-6	1999	Both L-arginine (10 mM) and NOC-18 (0.3 mM) counteracted the stimulatory effect on hERG1 outward currents induced by the radical oxygen species-generating system FeSO(4) (25 microM)/ascorbic acid (50 microM; Fe/Asc).	Arginine	5-15	potassium voltage-gated channel subfamily H member 2	Homo sapiens	83-88
10535747-4	1999	In contrast, an alphavbeta3 integrin-expressing cell line, SK-MEL-24, was able to adhere to OPN in an arginine-glycine-aspartic acid dependent manner.	Arginine	102-110	secreted phosphoprotein 1	Homo sapiens	92-95
10548560-1	1999	The signalling mechanisms involved in the induction of nitric oxide synthase and l-arginine transport were investigated in bacterial lipopolysaccharide (LPS)- and interferon-gamma (IFN-gamma)-stimulated rat cultured aortic smooth muscle cells (RASMCs).	Arginine	81-91	interferon gamma	Rattus norvegicus	163-179
10548560-1	1999	The signalling mechanisms involved in the induction of nitric oxide synthase and l-arginine transport were investigated in bacterial lipopolysaccharide (LPS)- and interferon-gamma (IFN-gamma)-stimulated rat cultured aortic smooth muscle cells (RASMCs).	Arginine	81-91	interferon gamma	Rattus norvegicus	181-190
10449634-1	1999	The role of adhesion molecules like osteopontin and bone sialoprotein, both containing the Arg-Gly-Asp sequence have been shown to have a role in mineral formation, whereas fibronectin (FN), another adhesive protein, was never studied during the mineralization processes.	Arginine	91-94	secreted phosphoprotein 1	Homo sapiens	36-47
10497157-3	1999	By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding.	Arginine	110-113	ATP binding cassette subfamily C member 9	Rattus norvegicus	39-43
10488123-1	1999	Three types of peptidylarginine deiminase (PAD), which converts a protein arginine residue to a citrulline residue, are widely distributed in animal tissues.	Arginine	23-31	peptidyl arginine deiminase 4	Homo sapiens	43-46
10491308-2	1999	The guanine base can form two specific hydrogen bonds with the active site residues Ser(121) and Val(73) and the attached negatively charged phosphate groups can entertain stabilizing electrostatic interactions with two clusters of positively charged patches on the PAP surface formed by Lys(210) and Arg(179) from one side and Arg(122) and Arg(135) from the other side of the active site.	Arginine	301-304	regenerating family member 3 alpha	Homo sapiens	266-269
10491308-2	1999	The guanine base can form two specific hydrogen bonds with the active site residues Ser(121) and Val(73) and the attached negatively charged phosphate groups can entertain stabilizing electrostatic interactions with two clusters of positively charged patches on the PAP surface formed by Lys(210) and Arg(179) from one side and Arg(122) and Arg(135) from the other side of the active site.	Arginine	328-331	regenerating family member 3 alpha	Homo sapiens	266-269
10491308-2	1999	The guanine base can form two specific hydrogen bonds with the active site residues Ser(121) and Val(73) and the attached negatively charged phosphate groups can entertain stabilizing electrostatic interactions with two clusters of positively charged patches on the PAP surface formed by Lys(210) and Arg(179) from one side and Arg(122) and Arg(135) from the other side of the active site.	Arginine	328-331	regenerating family member 3 alpha	Homo sapiens	266-269
10493802-16	1999	A mechanism is proposed in which Arg-11 interacts with the 6-carboxylate of the substrate to facilitate both substrate binding and catalysis and Arg-39 interacts with the 1-carboxylate and the 2-keto group of the substrate to promote carbonyl polarization and catalysis, while Pro-1 transfers protons from C-3 to C-5.	Arginine	33-36	lamin A/C	Homo sapiens	277-282
10493802-16	1999	A mechanism is proposed in which Arg-11 interacts with the 6-carboxylate of the substrate to facilitate both substrate binding and catalysis and Arg-39 interacts with the 1-carboxylate and the 2-keto group of the substrate to promote carbonyl polarization and catalysis, while Pro-1 transfers protons from C-3 to C-5.	Arginine	145-148	lamin A/C	Homo sapiens	277-282
10493803-4	1999	The pK(a) values of Pro-1 and of the essential acid group were determined independently from pH-rate profiles of the kinetic parameters of 4-OT in arginine mutants of 4-OT and compared with those of wild type.	Arginine	147-155	lamin A/C	Homo sapiens	20-25
10493803-12	1999	Mutation of Arg-39, by altering the structure of the beta-hairpin which covers the active site, could result in an increase in the solvent exposure of Pro-1, raising its upper limit pK(a) value to 8.2.	Arginine	12-15	lamin A/C	Homo sapiens	151-156
10493803-15	1999	It is concluded that the unusually low pK(a) of Pro-1 shows little contribution from electrostatic effects of the nearby cationic Arg-11, Arg-39, and Arg-61 residues but results primarily from a site of low local dielectric constant.	Arginine	130-133	lamin A/C	Homo sapiens	48-53
10493803-15	1999	It is concluded that the unusually low pK(a) of Pro-1 shows little contribution from electrostatic effects of the nearby cationic Arg-11, Arg-39, and Arg-61 residues but results primarily from a site of low local dielectric constant.	Arginine	138-141	lamin A/C	Homo sapiens	48-53
10493803-15	1999	It is concluded that the unusually low pK(a) of Pro-1 shows little contribution from electrostatic effects of the nearby cationic Arg-11, Arg-39, and Arg-61 residues but results primarily from a site of low local dielectric constant.	Arginine	138-141	lamin A/C	Homo sapiens	48-53
10596454-0	1999	Mutation of highly conserved arginine residues disrupts the structure and function of annexin V.	Arginine	29-37	annexin A5	Homo sapiens	86-95
10596454-5	1999	METHODS: To evaluate the role of the conserved arginines in the molecular structure of annexin V, negatively charged amino acids were substituted for arginines at positions R43, R115, R199, and R274 using site-directed mutagenesis.	Arginine	47-56	annexin A5	Homo sapiens	87-96
10596454-12	1999	CONCLUSIONS: Our data suggest that mutation of these highly conserved arginine residues in each of the four canonical domains of annexin have differential effects on the phospholipid binding, tertiary structure, and proteolytic susceptibility of annexin V.	Arginine	70-78	annexin A5	Homo sapiens	246-255
10596454-15	1999	Our data suggest that highly conserved arginine residues are required to stabilize the tertiary structure of annexin V by establishing hydrogen bonds and ionic bridges.	Arginine	39-47	annexin A5	Homo sapiens	109-118
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	163-166	cytochrome b5 type A	Homo sapiens	248-263
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	173-176	cytochrome b5 type A	Homo sapiens	248-263
10455016-5	1999	That the defect could be essentially reversed by lysine mutagenesis has led to the conclusion that the cationic charges on all three residues (at the positions of Arg(347), Arg(358), Arg(449)) are vital for the functional interaction of CYP17 with cytochrome b(5) and that the loss of any one of these cationic charges is catastrophic.	Arginine	173-176	cytochrome b5 type A	Homo sapiens	248-263
10404387-9	1999	To our knowledge, 3E10 is the first well characterized mAb specific for a subclass of polyproline-arg motif recognizing Sm B/B" and CD2 proteins.	Arginine	98-101	CD2 molecule	Homo sapiens	132-135
10430617-0	1999	The Gly972--&gt;Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.	Arginine	16-19	insulin receptor substrate 1	Homo sapiens	47-52
10430617-2	1999	The most prevalent IRS-1 variant, a Gly--&gt;Arg change at the codon 972, has been reported to be increased in prevalence among patients with type 2 diabetes.	Arginine	45-48	insulin receptor substrate 1	Homo sapiens	19-24
10430617-3	1999	Carriers of the Arg(972) substitution are characterized by lower fasting insulin and C-peptide levels compared with non-carriers, suggesting that the Arg(972) IRS-1 variant may contribute to impairment of insulin secretion.	Arginine	16-19	insulin receptor substrate 1	Homo sapiens	159-164
10430617-3	1999	Carriers of the Arg(972) substitution are characterized by lower fasting insulin and C-peptide levels compared with non-carriers, suggesting that the Arg(972) IRS-1 variant may contribute to impairment of insulin secretion.	Arginine	150-153	insulin receptor substrate 1	Homo sapiens	159-164
10465111-5	1999	Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively.	Arginine	76-79	melanocortin 1 receptor	Homo sapiens	132-136
10465111-5	1999	Furthermore, three missense mutations (V92M) and two silent mutations (CGA (Arg) to CGG (Arg), codon 213, exon 6) were found in the MC1R and p53 genes, respectively.	Arginine	89-92	melanocortin 1 receptor	Homo sapiens	132-136
10413516-9	1999	Results with this construct argue that CD4-mimicking molecules with surrogate structural elements for the Phe 43/Arg 59 components of CD4 are sufficient to elicit a similar gp120 conformational isomerization as expressed by CD4 itself.	Arginine	113-116	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	173-178
10391914-5	1999	We report that an arginine/lysine-rich region in the p47(phox) C terminus binds the p47(phox) SH3 domains expressed in tandem (SH3AB) but does not bind the individual N-terminal SH3A and C-terminal SH3B domains.	Arginine	18-26	pleckstrin	Homo sapiens	57-61
10407171-3	1999	Arginine can also be recycled from the citrulline produced by NOS activity, through argininosuccinate synthetase (AS) and argininosuccinate lyase (AL) activities, and metabolized by arginase.	Arginine	0-8	argininosuccinate lyase	Rattus norvegicus	122-145
10352183-3	1999	The corresponding full-length protein, named topors, contains a consensus RING zinc finger domain and nuclear localization signals in addition to the arginine-serine-rich region.	Arginine	150-158	TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	Homo sapiens	45-51
10352188-7	1999	Furthermore, l-arginine markedly increased the urinary excretion of beta2-microglobulin.	Arginine	13-23	beta-2-microglobulin	Homo sapiens	68-87
10352188-13	1999	The intense and simultaneous increment in beta2-microglobulin excretion strongly suggests that the effect of l-arginine on UAE is, in a relevant part, mediated through a blockade in the tubular protein reabsorption pathways.	Arginine	109-119	beta-2-microglobulin	Homo sapiens	42-61
10352188-14	1999	However, the profound differences observed in the changes induced by l-arginine on UAE and beta2-microglobulin excretion and the differences in the correlation of UAE and beta2-microglobulin with respect to GFR suggest that substantial diversity exists in the mechanisms by which l-arginine affects the renal management of albumin and beta2-microglobulin.	Arginine	69-79	beta-2-microglobulin	Homo sapiens	91-110
10428379-3	1999	Therefore, it appears that arginine binds to all of the NOS isozymes in an extended (E-like) conformation.	Arginine	27-35	tubulin folding cofactor E like	Homo sapiens	85-91
10394366-7	1999	In contrast to RasGAP and RhoGAP, Arg-74 could be substituted by lysine and contributed significantly to the binding of Ran.	Arginine	34-37	RAN, member RAS oncogene family	Homo sapiens	120-123
10350608-4	1999	The N-terminal sequence obtained for this fragment, VEAIG, indicates that the formation of p45 and p40 arises from the cleavage of p70 between arginine-319 and valine-320.	Arginine	143-151	septin 3	Rattus norvegicus	99-102
10224081-0	1999	Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.	Arginine	17-25	poly(A) binding protein nuclear 1	Homo sapiens	41-67
10353334-2	1999	Arginine, the substrate of nitric oxide synthases, might be recycled from the citrulline produced with NO by argininosuccinate synthetase (AS) and argininosuccinate lyase (AL).	Arginine	0-8	argininosuccinate lyase	Rattus norvegicus	147-170
10226337-5	1999	L-arginine administration also blunted the increases in interstitial volume, collagen deposition, and expression of alpha-smooth muscle actin in the obstructed kidney.	Arginine	0-10	actin gamma 2, smooth muscle	Rattus norvegicus	116-141
10212223-1	1999	Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.	Arginine	15-23	protein tyrosine phosphatase receptor type Z1	Homo sapiens	70-77
10208847-2	1999	It was shown that His256, located in the sixth TMD of the AT1 receptor, is needed for the agonist activation by the Phe8 side chain of angiotensin II, although replacing this residue with arginine or glutamine did not significantly alter the affinity binding of the receptor.	Arginine	188-196	angiotensin II receptor type 1 L homeolog	Xenopus laevis	58-61
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Arginine	34-37	SCT	Canis lupus familiaris	17-25
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Arginine	34-37	SCT	Canis lupus familiaris	147-155
10198322-8	1999	Secretin-Gly and secretin-Gly-Lys-Arg had potencies of 81 +/- 9% (P &gt; 0.05) and 176 +/- 13% (P &lt; 0.01), respectively, compared with amidated secretin, and the response to secretin-Gly-Lys-Arg lasted significantly longer.	Arginine	34-37	SCT	Canis lupus familiaris	147-155
10207276-8	1999	Although 10 mM of L-Arg significantly stimulated GnRH and c-GMP, but not neuropeptide Y, levels in both the MPOA and ME-ARC, GnRH and c-GMP in the ME-ARC were already increased by 1.0 mM of L-Arg.	Arginine	18-23	gonadotropin releasing hormone 1	Rattus norvegicus	49-53
10207276-8	1999	Although 10 mM of L-Arg significantly stimulated GnRH and c-GMP, but not neuropeptide Y, levels in both the MPOA and ME-ARC, GnRH and c-GMP in the ME-ARC were already increased by 1.0 mM of L-Arg.	Arginine	18-23	gonadotropin releasing hormone 1	Rattus norvegicus	125-129
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	113-116	insulin like growth factor binding protein 3	Homo sapiens	6-50
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	113-116	kallikrein related peptidase 3	Homo sapiens	186-211
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	121-124	insulin like growth factor binding protein 3	Homo sapiens	6-50
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	121-124	kallikrein related peptidase 3	Homo sapiens	186-211
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	121-124	insulin like growth factor binding protein 3	Homo sapiens	6-50
10218588-5	1999	Human insulin-like growth factor binding protein-3 was previously reported to be cleaved at five sites including Arg-97, Arg-132, Tyr-159, Phe-173 and Arg-179 by another group, however, prostate specific antigen preparation is possibly contaminated by trypsin-like protease.	Arginine	121-124	kallikrein related peptidase 3	Homo sapiens	186-211
9916123-3	1999	The ability to bind Hib PS resided exclusively with those Fab fragments having A2 and containing an insertional arginine at the variable-joining junction.	Arginine	112-120	FA complementation group B	Homo sapiens	58-61
10098704-0	1999	Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis.	Arginine	0-8	keratin 10	Homo sapiens	54-64
10098704-9	1999	Our results are compatible with the above classification and suggest that the arginine in the beginning of the 1A rod domain is the hot spot for the mutation of the keratin 10 gene.	Arginine	78-86	keratin 10	Homo sapiens	165-175
10405830-8	1999	The complementarity-determining region 3 (CDR3) of MDT.1 is arginine rich, with five out of 12 residues being arginine and these residues are candidates for interaction with the negatively charged ganglioside.	Arginine	60-68	retinol dehydrogenase 11	Homo sapiens	51-56
10405830-8	1999	The complementarity-determining region 3 (CDR3) of MDT.1 is arginine rich, with five out of 12 residues being arginine and these residues are candidates for interaction with the negatively charged ganglioside.	Arginine	110-118	retinol dehydrogenase 11	Homo sapiens	51-56
10100484-5	1999	Contrin is highly basic and is rich in the amino acids arginine and proline.	Arginine	55-63	Y-box binding protein 2	Homo sapiens	0-7
17312667-14	1999	Arginine is gaining a prominent position as a part of the therapeutic arsenal in the management of LA-NO pathway-related disorders.	Arginine	0-8	leucine rich repeat containing 1	Homo sapiens	99-104
10447101-5	1999	The nuclear magnetic resonance analysis of MT-II suggested involvement of Phe and Arg residues in H-bonds stabilizing the bent conformations of the peptide backbone.	Arginine	82-85	metallothionein 2A	Homo sapiens	43-48
10645145-4	1999	A pharmacokinetic effects of beta 3-agonists and putative involvement of Trp/Arg mutation in beta 3-AR gene in obesity and another metabolic disorders have been discussed.	Arginine	77-80	adrenoceptor beta 3	Homo sapiens	93-102
9817840-6	1998	The overall N domain structure in the context of the NK1 fragment is similar to the structure of the isolated domain; two lysines and an arginine residue coordinate a bound sulfate ion.	Arginine	137-145	tachykinin receptor 1	Homo sapiens	53-56
9817840-11	1998	CONCLUSIONS: A cluster of exposed lysine and arginine residues in or near the hairpin-loop region of the N domain might form part of the NK1 heparin-binding site.	Arginine	45-53	tachykinin receptor 1	Homo sapiens	137-140
9804899-7	1998	Activated macrophages decreased CAT1 levels, but accumulated CAT2 and iNOS mRNA and protein with parallel kinetics suggesting that CAT2 mediated L-arginine transport might regulate the L-arginine:nitric oxide pathway.	Arginine	145-155	inositol-3-phosphate synthase 1	Homo sapiens	70-74
9804899-7	1998	Activated macrophages decreased CAT1 levels, but accumulated CAT2 and iNOS mRNA and protein with parallel kinetics suggesting that CAT2 mediated L-arginine transport might regulate the L-arginine:nitric oxide pathway.	Arginine	185-195	inositol-3-phosphate synthase 1	Homo sapiens	70-74
9858782-0	1998	Exposure of the cryptic Arg-Gly-Asp sequence in thrombospondin-1 by protein disulfide isomerase.	Arginine	24-27	thrombospondin 1	Bos taurus	48-64
9858782-3	1998	This interaction is mediated via a cryptic Arg-Gly-Asp sequence in the C-terminal Ca2+-binding region of thrombospondin-1.	Arginine	43-46	thrombospondin 1	Bos taurus	105-121
9858782-5	1998	Limited reduction of thrombospondin-1 by dithiothreitol exposes the Arg-Gly-Asp sequence which can bind to the alphav beta3 integrin receptor and support endothelial cell spreading (X.	Arginine	68-71	thrombospondin 1	Bos taurus	21-37
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Arginine	137-140	thrombospondin 1	Bos taurus	13-29
9858782-13	1998	Treatment of thrombospondin-1 with purified protein disulfide isomerase enhanced adhesion of endothelial cells to thrombospondin-1 in an Arg-Gly-Asp-dependent manner through the alphav beta3 integrin receptor and supported cell spreading.	Arginine	137-140	thrombospondin 1	Bos taurus	114-130
9858782-15	1998	These results suggest that endothelial cell derived protein disulfide isomerase may regulate Arg-Gly-Asp-dependent binding of thrombospondin-1.	Arginine	93-96	thrombospondin 1	Bos taurus	126-142
9833037-8	1998	The same arginine position has been mutated in the keratin 10 gene in epidermolytic hyperkeratosis, the keratin 14 gene in epidermolysis bullosa simplex, and the keratin 9 gene in hereditary EPPK in Western patients.	Arginine	9-17	keratin 10	Homo sapiens	51-61
9833037-8	1998	The same arginine position has been mutated in the keratin 10 gene in epidermolytic hyperkeratosis, the keratin 14 gene in epidermolysis bullosa simplex, and the keratin 9 gene in hereditary EPPK in Western patients.	Arginine	9-17	keratin 14	Homo sapiens	104-114
9814988-2	1998	Replacement of five arginines with N (5R/N) or T residues in the initial COOH-terminal domain (CT1) of Cx32 enhanced CO2 sensitivity.	Arginine	20-29	gap junction protein beta 1 L homeolog	Xenopus laevis	103-107
9786970-6	1998	At a holding potential of -100 mV, the inward current through Kir7.1 averaged -3.8 +/- 1.04 microA with 2 mM [K+]e and -4.82 +/- 1.87 microA with 96 mM [K+]e. Kir7.1 has a methionine at position 125 in the pore region where other Kir channels have an arginine.	Arginine	251-259	potassium inwardly-rectifying channel, subfamily J, member 13	Rattus norvegicus	62-68
9786970-7	1998	When this residue was replaced by the conserved arginine in mutant Kir7.1 channels, the pronounced dependence of K+ permeability on [K+]e, characteristic for other Kir channels, was restored and the Ba2+ sensitivity was increased by a factor of approximately 25 (Ki = 27 microM).	Arginine	48-56	potassium inwardly-rectifying channel, subfamily J, member 13	Rattus norvegicus	67-73
9746558-2	1998	The peptide repertoire of HLA-B27 complexes was analyzed by two different methods: (i) high-pressure liquid chromatography (HPLC) profiles of newly synthesized peptides eluted from B27 following metabolic labeling with arginine and (ii) reactivities with two B27 monoclonal antibodies, Ye-2 and B27.M2, sensitive to peptide-induced conformational changes.	Arginine	219-227	major histocompatibility complex, class I, B	Homo sapiens	26-33
9730985-7	1998	Arg-Gly-Asp peptides or fragments of fibronectin that contain the Arg-Gly-Asp cell binding site promoted clustering of the (&amp;agr ;)5beta1 integrin in focal adhesions, but did not enhance cell growth.	Arginine	0-3	fibronectin 1	Mus musculus	37-48
11263239-3	1998	It was found that the vasomotion was significantly enhanced after administration of L-arginine(which is donor of EDRF/NO), and L-arginine induces a sequence of changes in cochlear blood flow.	Arginine	84-94	alpha hemoglobin stabilizing protein	Homo sapiens	113-117
9753477-0	1998	The oligomycin sensitivity conferring protein of rat liver mitochondrial ATP synthase: arginine 94 is important for the binding of OSCP to F1.	Arginine	87-95	ATP synthase peripheral stalk subunit OSCP	Rattus norvegicus	131-135
9753477-9	1998	These results demonstrate that a single tight binding site exists on isolated rat liver F1 for OSCP, and implicate arginine 94 as playing a critical role in this site.	Arginine	115-123	ATP synthase peripheral stalk subunit OSCP	Rattus norvegicus	95-99
9802389-0	1998	NPY Y1 antagonists: structure-activity relationships of arginine derivatives and hybrid compounds with arpromidine-like partial structures.	Arginine	56-64	neuropeptide Y	Homo sapiens	0-3
9730889-6	1998	The NP1 product displaced approximately 90% of the 3H-Arg-labeled endogenous peptide fraction in B27(+)NP1(+) spleen cells.	Arginine	54-57	neuronal pentraxin 1	Rattus norvegicus	4-7
9730889-6	1998	The NP1 product displaced approximately 90% of the 3H-Arg-labeled endogenous peptide fraction in B27(+)NP1(+) spleen cells.	Arginine	54-57	neuronal pentraxin 1	Rattus norvegicus	103-106
9730896-6	1998	The transmembrane region contains the positively charged amino acid Arg, which is possibly involved in stabilizing the association with CD3zeta chain.	Arginine	68-71	CD247 molecule	Homo sapiens	136-149
9743205-0	1998	Comparison of the frequencies of arginines in heavy chain CDR3 of antibodies expressed in the primary B-cell repertoires of autoimmune-prone and normal mice.	Arginine	33-42	cerebellar degeneration-related 3	Mus musculus	58-62
9743205-2	1998	The VH structures of most autoimmune anti-DNA antibodies include at least one arginine in VH-CDR3; moreover, antibody specificity for dsDNA can be correlated to the relative position of arginines in VH-CDR3.	Arginine	78-86	cerebellar degeneration-related 3	Mus musculus	93-97
9743205-2	1998	The VH structures of most autoimmune anti-DNA antibodies include at least one arginine in VH-CDR3; moreover, antibody specificity for dsDNA can be correlated to the relative position of arginines in VH-CDR3.	Arginine	78-86	cerebellar degeneration-related 3	Mus musculus	202-206
9743205-2	1998	The VH structures of most autoimmune anti-DNA antibodies include at least one arginine in VH-CDR3; moreover, antibody specificity for dsDNA can be correlated to the relative position of arginines in VH-CDR3.	Arginine	186-195	cerebellar degeneration-related 3	Mus musculus	93-97
9743205-2	1998	The VH structures of most autoimmune anti-DNA antibodies include at least one arginine in VH-CDR3; moreover, antibody specificity for dsDNA can be correlated to the relative position of arginines in VH-CDR3.	Arginine	186-195	cerebellar degeneration-related 3	Mus musculus	202-206
9743205-3	1998	The coding sequences for most VH-CDR3 arginines among the anti-DNA MoAbs we have studied to date appeared to have been encoded by sequences generated during V-D-J recombination and would have been expressed in the primary B-cell repertoire.	Arginine	38-47	cerebellar degeneration-related 3	Mus musculus	33-37
9743205-7	1998	The high frequency of recurrence of VH-CDR3 arginines among autoimmune anti-DNA in (NZB x NZW)F1 mice would appear to derive from the selective oligoclonal expansion of selected B cells that express such structures.	Arginine	44-53	cerebellar degeneration-related 3	Mus musculus	39-43
9679769-0	1998	Laminin-alpha1-chain sequence Leu-Gln-Val-Gln-Leu-Ser-Ile-Arg (LQVQLSIR) enhances murine melanoma cell metastases.	Arginine	58-61	laminin, alpha 1	Mus musculus	0-14
9694882-5	1998	An Arg to Glu mutation within the FLVRQS motif in the SH2 domain of SH2-Bbeta inhibited GST-SH2-Bbeta binding to tyrosyl-phosphorylated PDGFR.	Arginine	3-6	hematopoietic prostaglandin D synthase	Mus musculus	88-91
9694882-5	1998	An Arg to Glu mutation within the FLVRQS motif in the SH2 domain of SH2-Bbeta inhibited GST-SH2-Bbeta binding to tyrosyl-phosphorylated PDGFR.	Arginine	3-6	platelet derived growth factor receptor, beta polypeptide	Mus musculus	136-141
9757574-1	1998	Human NP220 (hNP220) is a novel DNA-binding nuclear protein, which has an arginine/serine-rich motif and polypyrimidine tract-binding motif, and NP220s and matrin 3 are thought to form a novel family of nuclear proteins.	Arginine	74-82	zinc finger protein 638	Homo sapiens	6-11
9757574-1	1998	Human NP220 (hNP220) is a novel DNA-binding nuclear protein, which has an arginine/serine-rich motif and polypyrimidine tract-binding motif, and NP220s and matrin 3 are thought to form a novel family of nuclear proteins.	Arginine	74-82	zinc finger protein 638	Homo sapiens	13-19
9734870-9	1998	Peak values of insulin and glucagon following the arginine injection were significantly higher in the hot than in the TN environment.	Arginine	50-58	insulin	Bos taurus	15-22
9726818-9	1998	The most frequent Ki-ras mutation was an arginine (CGA)AT --&gt; GC transition at codon 61 in exon 2.	Arginine	41-49	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	18-24
9726818-11	1998	Ki-ras mutations at codon 61 (Arg) may therefore influence the growth or development of 1-NP-induced lung lesions in A/J mice.	Arginine	30-33	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-6
9677388-6	1998	Arg162 --&gt; His mutation increased Km 40-fold and reduced Vmax 5-fold, providing the first biochemical evidence for this conserved Arg residue (Arg178 in human beta-N-acetylhexosaminidase A (HexA) and Arg349 in SmChb) as a substrate-binding residue in a family 20 enzyme, a finding consistent with our three-dimensional model of SpHex.	Arginine	0-3	hexosaminidase subunit alpha	Homo sapiens	193-197
9703961-7	1998	This is the first demonstration that PC1 acting alone is able to cleave pro CCK liberating the amino terminal pro peptide and a glycine and arginine extended CCK 8 which is the immediate precursor of CCK 8 amide.	Arginine	140-148	proprotein convertase subtilisin/kexin type 1	Homo sapiens	37-40
9688851-0	1998	Ca2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy.	Arginine	56-59	troponin T1, slow skeletal type	Homo sapiens	66-76
9632785-4	1998	hU2AF65 contains an arginine-serine-rich (RS) domain and three RNA recognition motifs (RRMs).	Arginine	20-28	U2 small nuclear RNA auxiliary factor 2	Homo sapiens	0-7
9702068-2	1998	In human beta 3-adrenoceptor, a Trp to Arg replacement has recently been discovered.	Arginine	39-42	adrenoceptor beta 3	Homo sapiens	9-28
9662426-1	1998	Bacterial lipopolysaccharide (LPS) in the presence of interferon gamma (IFNgamma) stimulates the synthesis of the cationic amino acid transporter 2B (CAT-2B) and inducible nitric oxide synthetase (iNOS) in RAW264 macrophages, which are thought to underlie the increased rate of arginine uptake into these cells and its conversion to nitric oxide, respectively.	Arginine	278-286	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	114-148
9662426-1	1998	Bacterial lipopolysaccharide (LPS) in the presence of interferon gamma (IFNgamma) stimulates the synthesis of the cationic amino acid transporter 2B (CAT-2B) and inducible nitric oxide synthetase (iNOS) in RAW264 macrophages, which are thought to underlie the increased rate of arginine uptake into these cells and its conversion to nitric oxide, respectively.	Arginine	278-286	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	150-156
9633935-1	1998	To characterize the clinical features associated with the Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR), the effects of this mutation, in particular the homozygous state (Arg/Arg), on obesity, blood pressure, and plasma lipoproteins were investigated in 2 populations: subjects residing on a small isolated island (group 1; n=746) and patients residing in Tokyo who attend a clinic for metabolic diseases (group 2; n=371).	Arginine	63-66	adrenoceptor beta 3	Homo sapiens	83-108
9633935-1	1998	To characterize the clinical features associated with the Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR), the effects of this mutation, in particular the homozygous state (Arg/Arg), on obesity, blood pressure, and plasma lipoproteins were investigated in 2 populations: subjects residing on a small isolated island (group 1; n=746) and patients residing in Tokyo who attend a clinic for metabolic diseases (group 2; n=371).	Arginine	63-66	adrenoceptor beta 3	Homo sapiens	110-118
9601054-6	1998	It was found that the mutation of Lys83, Arg347 and Arg358 produced proteins that were deficient in their responsiveness to cytochrome b5, and the effect was most pronounced for the two arginine mutants (Arg347--&gt;His and Arg358--&gt;Gln) which have been found in male patients suffering from genital ambiguity.	Arginine	186-194	cytochrome b5 type A	Homo sapiens	124-137
9687021-6	1998	The order for k(cat)/Km values of AAP-S at the optimal pH (pH 7.5) was Lys-&gt;Met-&gt;Arg-&gt;Ala-&gt;Leu-&gt;Phe-&gt;Tyr-&gt;Lys-Ala-MCAs.	Arginine	87-90	alanyl aminopeptidase, membrane	Rattus norvegicus	34-39
9654140-1	1998	The stimulatory effects of several DNA-binding basic proteins (histone and protamine) and HIV-1 Rev with arginine (Arg)-rich clusters on the activity of casein kinase II (CK-II) were investigated in vitro.	Arginine	105-113	casein kinase 2 alpha 1	Homo sapiens	171-176
9654140-1	1998	The stimulatory effects of several DNA-binding basic proteins (histone and protamine) and HIV-1 Rev with arginine (Arg)-rich clusters on the activity of casein kinase II (CK-II) were investigated in vitro.	Arginine	115-118	casein kinase 2 alpha 1	Homo sapiens	171-176
9654140-2	1998	It was found that recombinant Rev (rRev) and the synthetic oligo-fragments corresponding to the amino acid sequences of its Arg-rich cluster stimulate CK-II activity in a dose-dependent manner.	Arginine	124-127	casein kinase 2 alpha 1	Homo sapiens	151-156
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Arginine	182-192	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	4-10
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Arginine	182-192	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	77-83
9565624-4	1998	In HuH-7.MCAT-1 cells, L-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased L-arginine uptake along with cellular DNA synthesis.	Arginine	23-33	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	Mus musculus	9-15
9538004-0	1998	Rhodopsin arginine-135 mutants are phosphorylated by rhodopsin kinase and bind arrestin in the absence of 11-cis-retinal.	Arginine	10-18	G protein-coupled receptor kinase 1	Homo sapiens	53-69
9544996-7	1998	The mRNAs of argininosuccinate synthetase and argininosuccinate lyase, the enzymes that metabolize citrulline to arginine, were detectable only in the upper part of the villi, whereas the other mRNAs were concentrated in the crypts.	Arginine	113-121	argininosuccinate lyase	Rattus norvegicus	46-69
9494113-1	1998	Agmatine is an amine derived from the decarboxylation of arginine by arginine decarboxylase (ADC) and metabolized to putrescine by agmatinase.	Arginine	57-65	antizyme inhibitor 2	Homo sapiens	69-91
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Arginine	115-118	guanylate cyclase 2E, pseudogene	Homo sapiens	283-286
9447963-5	1998	The predicted Sip1 sequence contains an arginine-serine-rich (RS) domain but does not have any known RNA-binding motifs, indicating that it is not a member of the SR family.	Arginine	40-48	septin interacting protein 1	Drosophila melanogaster	14-18
9507064-6	1998	We found that mK1, mK9 and mK13 preferentially cleaved the former two types of substrate, except Y-Arg-Arg-MCA.	Arginine	99-102	keratin 1	Mus musculus	14-17
9422738-7	1998	Only PC2, but not furin or PC1/PC3, could cleave the Arg-Pro bond to yield Dyn 1-8.	Arginine	53-56	proprotein convertase subtilisin/kexin type 2	Homo sapiens	5-8
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	phosphatase and tensin homolog	Homo sapiens	51-55
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	phosphatase and tensin homolog	Homo sapiens	56-61
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	phosphatase and tensin homolog	Homo sapiens	184-188
9467947-8	1998	However, because the putative initiation codon for PTEN/MMAC1 gene was changed to arginine in PTH2, the translational initiation site of PTH2 is very likely to differ from that of the PTEN/MMAC1.	Arginine	82-90	phosphatase and tensin homolog	Homo sapiens	189-194
10200053-7	1998	A single nucleotide substitution of guanine to adenine, in codon 1612, changed the coding sense of the SCN5A from arginine to glutamine (R1623Q) in the S4 segment of domain IV which is a highly conserved region of the SCN5A.	Arginine	114-122	sodium voltage-gated channel alpha subunit 5	Homo sapiens	103-108
10200053-7	1998	A single nucleotide substitution of guanine to adenine, in codon 1612, changed the coding sense of the SCN5A from arginine to glutamine (R1623Q) in the S4 segment of domain IV which is a highly conserved region of the SCN5A.	Arginine	114-122	sodium voltage-gated channel alpha subunit 5	Homo sapiens	218-223
9575420-8	1998	Antiproliferative and differentiation inducing effects of hCRF in W256 cells involve activation of nitric oxide synthase (NOS) and L-arginine-NO pathway.	Arginine	131-141	corticotropin releasing hormone	Homo sapiens	58-62
9686345-1	1998	Nitric oxide (NO) is synthesized from arginine by nitric-oxide synthase (NOS), and citrulline that is generated can be recycled to arginine by argininosuccinate synthase (AS) and argininosuccinate lyase (AL).	Arginine	131-139	argininosuccinate lyase	Rattus norvegicus	179-202
9371719-5	1997	gACE from human sperm cleaved Arg-Arg from the C-terminus of the CCK5-GRR (GWMDFGRR), a peptide corresponding to the C-terminus of a CCK-gastrin prohormone intermediate.	Arginine	30-33	gastrin	Homo sapiens	137-144
9371719-5	1997	gACE from human sperm cleaved Arg-Arg from the C-terminus of the CCK5-GRR (GWMDFGRR), a peptide corresponding to the C-terminus of a CCK-gastrin prohormone intermediate.	Arginine	34-37	gastrin	Homo sapiens	137-144
9426386-1	1997	OBJECTIVE: A polymorphism in the beta 3-adrenergic receptor (beta 3-AR) has been described and consists of an amino acid substitution at position 64 where tryptophan is replaced by arginine (Arg allele).	Arginine	191-194	adrenoceptor beta 3	Homo sapiens	33-59
9426386-1	1997	OBJECTIVE: A polymorphism in the beta 3-adrenergic receptor (beta 3-AR) has been described and consists of an amino acid substitution at position 64 where tryptophan is replaced by arginine (Arg allele).	Arginine	191-194	adrenoceptor beta 3	Homo sapiens	61-70
9398712-6	1997	In the other allele, a deletion of 3 nucleotides in codons 337-338 in exon 5 resulted in a substitution of arginine to histidine and a deletion of tyrosine residue (CGCTAT to CAT: R337H, delta Y338), which has been previously shown to abolish 11 beta HSD2 enzyme activity.	Arginine	107-115	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	251-255
9348274-15	1997	GH and EGF combination therapy significantly increased alanine and arginine transport in distal small bowel after 70 % enterectomy but not in the proximal small bowel.	Arginine	67-75	epidermal growth factor	Homo sapiens	7-10
9354792-4	1997	The lethal milk mutant has a nonsense mutation at arginine codon 297 in the Znt4 gene.	Arginine	50-58	solute carrier family 30 (zinc transporter), member 4	Mus musculus	76-80
9351809-6	1997	In addition, the structures show how an arginine residue (Arg77) of Nef interacts with Asp 100 of the so-called RT loop within the Fyn SH3 domain, and triggers a hydrogen-bond rearrangement which allows the loop to adapt to complement the Nef surface.	Arginine	40-48	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	131-134
9299442-4	1997	NO measurement by NO selective electrode revealed that NO production in the rat and human uterus treated with IL-1 alpha was promoted by the addition of 1 mM L-arginine to the culture medium.	Arginine	158-168	interleukin 1 alpha	Homo sapiens	110-120
9260860-1	1997	Nitric oxide (NO), a gaseous molecule synthesized in the arteriolar endothelium from the amino acid L-arginine (L-arg), has been identified as the previously described Endothelium-Derived Relaxing Factor (EDRF): nitroderivatives such as nitroglycerin are known to induce vasodilation via NO release.	Arginine	100-110	alpha hemoglobin stabilizing protein	Homo sapiens	168-203
9260860-1	1997	Nitric oxide (NO), a gaseous molecule synthesized in the arteriolar endothelium from the amino acid L-arginine (L-arg), has been identified as the previously described Endothelium-Derived Relaxing Factor (EDRF): nitroderivatives such as nitroglycerin are known to induce vasodilation via NO release.	Arginine	100-110	alpha hemoglobin stabilizing protein	Homo sapiens	205-209
9260860-1	1997	Nitric oxide (NO), a gaseous molecule synthesized in the arteriolar endothelium from the amino acid L-arginine (L-arg), has been identified as the previously described Endothelium-Derived Relaxing Factor (EDRF): nitroderivatives such as nitroglycerin are known to induce vasodilation via NO release.	Arginine	100-105	alpha hemoglobin stabilizing protein	Homo sapiens	168-203
9260860-1	1997	Nitric oxide (NO), a gaseous molecule synthesized in the arteriolar endothelium from the amino acid L-arginine (L-arg), has been identified as the previously described Endothelium-Derived Relaxing Factor (EDRF): nitroderivatives such as nitroglycerin are known to induce vasodilation via NO release.	Arginine	100-105	alpha hemoglobin stabilizing protein	Homo sapiens	205-209
9493221-1	1997	Nitric oxide (NO) has been identified as the mediator accounting for the biological effects of endothelium-derived relaxing factor (EDRF) and has been shown to be generated by the action of constitutive and inducible NO-synthases (NOSs) from L-arginine in a variety of cells, including macrophages, neurons and endothelial cells.	Arginine	242-252	alpha hemoglobin stabilizing protein	Homo sapiens	95-130
9493221-1	1997	Nitric oxide (NO) has been identified as the mediator accounting for the biological effects of endothelium-derived relaxing factor (EDRF) and has been shown to be generated by the action of constitutive and inducible NO-synthases (NOSs) from L-arginine in a variety of cells, including macrophages, neurons and endothelial cells.	Arginine	242-252	alpha hemoglobin stabilizing protein	Homo sapiens	132-136
9268348-5	1997	Amino acids essential for binding of antibodies weakly or moderately competing with sH attachment are situated in the membrane-distal tip of CCP-I, whereas residues involved in binding of strongly sH competing antibodies cluster in the center of CCP-I (Arg-25, Asp-27) or in CCP-II (Arg-69, Asp-70).	Arginine	253-256	granzyme B	Homo sapiens	246-251
9241232-11	1997	Mutations of K241 to Gln (K241Q) and Arg (K241R) have been obtained after site directed mutagenesis of OGG1.	Arginine	37-40	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	103-107
9242619-4	1997	Furthermore, the deimination of P1 Arg converts antithrombin to a form with 4-fold higher affinity for the heparin pentasaccharide, similar to the affinity found for the P1 His variant, due to a lowered dissociation rate constant for the antithrombin-pentasaccharide complex.	Arginine	35-38	serpin family C member 1	Homo sapiens	48-60
9242619-0	1997	Heparin-dependent modification of the reactive center arginine of antithrombin and consequent increase in heparin binding affinity.	Arginine	54-62	serpin family C member 1	Homo sapiens	66-78
9242619-3	1997	Here we show that the side chain of the P1 Arg of alpha-antithrombin is only accessible to modification by the enzyme peptidylarginine deiminase on addition of the heparin pentasaccharide, thereby inactivating the inhibitor, whereas the natural P1 His variant, antithrombin Glasgow, is unaffected, indicating that only the P1 Arg becomes accessible.	Arginine	43-46	serpin family C member 1	Homo sapiens	56-68
9242619-3	1997	Here we show that the side chain of the P1 Arg of alpha-antithrombin is only accessible to modification by the enzyme peptidylarginine deiminase on addition of the heparin pentasaccharide, thereby inactivating the inhibitor, whereas the natural P1 His variant, antithrombin Glasgow, is unaffected, indicating that only the P1 Arg becomes accessible.	Arginine	43-46	serpin family C member 1	Homo sapiens	261-273
9242619-3	1997	Here we show that the side chain of the P1 Arg of alpha-antithrombin is only accessible to modification by the enzyme peptidylarginine deiminase on addition of the heparin pentasaccharide, thereby inactivating the inhibitor, whereas the natural P1 His variant, antithrombin Glasgow, is unaffected, indicating that only the P1 Arg becomes accessible.	Arginine	326-329	serpin family C member 1	Homo sapiens	56-68
9242619-4	1997	Furthermore, the deimination of P1 Arg converts antithrombin to a form with 4-fold higher affinity for the heparin pentasaccharide, similar to the affinity found for the P1 His variant, due to a lowered dissociation rate constant for the antithrombin-pentasaccharide complex.	Arginine	35-38	serpin family C member 1	Homo sapiens	238-250
9242619-5	1997	The results support the proposal that antithrombin circulates in a constrained conformation, which when released, in this study by perturbation of the bonding of P1 Arg to the body of the molecule, allows the reactive site loop to take up the active inhibitory conformation with exposure of the P1 Arg.	Arginine	165-168	serpin family C member 1	Homo sapiens	38-50
9242619-5	1997	The results support the proposal that antithrombin circulates in a constrained conformation, which when released, in this study by perturbation of the bonding of P1 Arg to the body of the molecule, allows the reactive site loop to take up the active inhibitory conformation with exposure of the P1 Arg.	Arginine	298-301	serpin family C member 1	Homo sapiens	38-50
9235981-9	1997	Structure-activity correlation showed that fibrinogen-like acyl-GPRP and acyl-GHRP could inhibit D. E association at the millimolar range, but in a manner different from fibrin-related GPR peptides did, which required the NH2 as well as Arg presence.	Arginine	237-240	glutathione peroxidase 2	Homo sapiens	64-68
9223509-6	1997	Subsequent studies demonstrated that the SCR2 domain of baboon CD46 contained an Arg-to-Gln mutation at amino acid position 103 which accounted for reduced hemagglutination activity.	Arginine	81-84	membrane cofactor protein	Papio anubis	63-67
9230196-3	1997	We amplified and sequenced the multiple arginine coding area of the ARP gene in primary head and neck, non-small cell lung, and renal cell cancers.	Arginine	40-48	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	68-71
9296349-5	1997	cDNA-expressed CYP2C9 (Arg 144 and Cys 144) favored S-2- and S-3-hydroxyibuprofen formation, but CYP2C8 favored R-2-hydroxyibuprofen formation.	Arginine	23-26	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	15-21
9202292-2	1997	In one case, the editing changes a gene-encoded glutamine (Q) to an arginine (R) codon located in the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR-B and also the kainate receptor subunits GluR5 and GluR6.	Arginine	68-76	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	265-270
9202292-3	1997	Another case of RNA editing alters an arginine (R) to a glycine (G) codon at a position termed the "R/G" site of AMPA subunits GluR-B, C, and D. Double-stranded RNA-specific adenosine deaminases (DRADA) have been implicated as agents involved in the editing.	Arginine	38-46	adenosine deaminase RNA specific	Homo sapiens	145-194
9357156-4	1997	The advent of molecular biology techniques has enabled isolation of cDNA for the inhibitors PAI-1, PAI-2 and PAI-3 and data indicate that these belong to the serine protease inhibitor (Serpine) family with arginine as its active site but immunologically distinct from each other.	Arginine	206-214	serpin family E member 1	Homo sapiens	92-97
9467753-1	1997	Splenopentin (SP-5), is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin.	Arginine	87-90	Sp5 transcription factor	Homo sapiens	14-18
9139847-8	1997	Our findings suggest that tumor cytostasis of neutrophils activated by rIFN-gamma is mediated by L-arginine-derived nitrogen oxidation products, and that O(2)- produced by these neutrophils reduces NO-mediated tumor cytostasis at low NO concentrations.	Arginine	97-107	interferon gamma	Rattus norvegicus	71-81
9126751-8	1997	An adhesion assay with extracellular matrix proteins demonstrated that C1300 NB cells adhered preferentially to vitronectin and fibronectin, and the adherence was strongly inhibited by Arg-Gly-Asp (RGD)-containing peptides.	Arginine	185-188	fibronectin 1	Mus musculus	128-139
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Arginine	95-103	keratin 10	Homo sapiens	64-67
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Arginine	95-103	keratin 10	Homo sapiens	221-224
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Arginine	105-108	keratin 10	Homo sapiens	64-67
9184002-3	1997	The patient had a G to A transition at codon 156 of the keratin K10 gene, which resulted in an arginine (Arg)--&gt;histidine (His) substitution in the helix initiation peptide of the highly-conserved 1A domain in keratin K10.	Arginine	105-108	keratin 10	Homo sapiens	221-224
9065690-1	1997	Expression of the catabolic gene encoding arginase in Saccharomyces cerevisiae, CAR1, is controlled by multiple nitrogen signals, such as the presence of the inducer, arginine, and the nature and amount of the nitrogen source.	Arginine	167-175	arginase	Saccharomyces cerevisiae S288C	80-84
9078278-0	1997	Highly conserved residue arginine-15 is required for the Ca2+-dependent properties of the gamma-carboxyglutamic acid domain of human anticoagulation protein C and activated protein C. The function of the rigidly conserved amino acid residue R15 in the Ca2+/phospholipid-dependent properties of the gamma-carboxyglutamic acid (Gla)-containing domain (GD) of human Protein C (PC) were investigated through site-directed mutagenesis strategies.	Arginine	25-33	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	363-377
9020087-7	1997	We introduced site-directed mutations to change the Lys-129 of CD38 to Ala and to Arg.	Arginine	82-85	CD38 molecule	Homo sapiens	63-67
9032444-1	1997	Arg-136, Glu-137, Arg-138 and Arg-139 are conserved in all sequences of the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	Arginine	0-3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	95-147
9032444-1	1997	Arg-136, Glu-137, Arg-138 and Arg-139 are conserved in all sequences of the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	Arginine	18-21	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	95-147
9032444-1	1997	Arg-136, Glu-137, Arg-138 and Arg-139 are conserved in all sequences of the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	Arginine	18-21	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	95-147
9030829-1	1997	Prompted by the recent findings that a tryptophan to arginine (Trp64Arg) mutation in the beta3-adrenergic receptor gene was associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indians, with abdominal obesity and insulin resistance in Finns, and with an increased capacity to gain weight in French whites, we studied the prevalence of this mutation in 231 diabetic and 95 nondiabetic Japanese subjects and assessed its contribution to the development of obesity and NIDDM.	Arginine	53-61	adrenoceptor beta 3	Homo sapiens	89-114
9018112-4	1997	In this study, we have introduced a MEN 2A mutation (Cys634--&gt;Arg) and the unique MEN 2B mutation (Met918--&gt;Thr) in two RET isoforms of 1114 and 1072 amino acids which differ in the carboxy-terminus part.	Arginine	65-68	ret proto-oncogene	Homo sapiens	126-129
9003434-5	1997	Lysine-dependent plasminogen binding to r-alpha-enolase was demonstrated by a greater than 80% inhibition of binding by the lysine analogues epsilon-amino caproic acid and tranexamic acid, whilst only 14% inhibition occurred with the arginine analogue benzamidine.	Arginine	234-242	enolase 1	Homo sapiens	42-55
9685993-3	1997	It exhibits an in vitro selectivity for peptide bonds at the N-terminus of Arg (R) moieties in dibasic sites and was thus called NRD convertase (Nardilysin: EC 3.4.24.61).	Arginine	75-78	nardilysin convertase	Rattus norvegicus	129-143
9685993-3	1997	It exhibits an in vitro selectivity for peptide bonds at the N-terminus of Arg (R) moieties in dibasic sites and was thus called NRD convertase (Nardilysin: EC 3.4.24.61).	Arginine	75-78	nardilysin convertase	Rattus norvegicus	145-155
9685993-5	1997	The aminopeptidase B component is a 72 kDa metalloexopeptidase which is able to remove Lys and Arg residues from naphtylamide derivatives and from the N-terminus of various peptide substrates.	Arginine	95-98	arginyl aminopeptidase	Rattus norvegicus	4-20
8980461-0	1997	Role of resident mast cells and macrophages in the neutrophil migration induced by LTB4, fMLP and C5a des arg.	Arginine	106-109	complement C5	Rattus norvegicus	98-101
8980461-2	1997	The intraperitoneal injection of LTB4 (10 nmol), fMLP (10 nmol) and C5a des arg (zymosan-activated plasma, 1 ml) caused an intense neutrophil migration compared to the saline control (1,000, 1,500 and 2,000%, respectively).	Arginine	76-79	complement C5	Rattus norvegicus	68-71
8980461-6	1997	Pretreating the animals with dexamethasone strongly inhibited (70%) the neutrophil migration induced by the intraperitoneal injection of LTB4, fMLP and C5a des arg.	Arginine	160-163	complement C5	Rattus norvegicus	152-155
8980461-10	1997	In contrast, stimulating the cells with fMLP or C5a des arg did not result in the release of any promigratory activity into the incubating fluid.	Arginine	56-59	complement C5	Rattus norvegicus	48-51
8980461-11	1997	Our results suggest that LTB4 induces neutrophil migration via a mechanism dependent on resident mast cells and macrophages while that induced by C5a des arg and fMLP seems to be independent of such cellular involvement.	Arginine	154-157	complement C5	Rattus norvegicus	146-149
9005972-3	1997	We investigated whether amylin also inhibits alpha-cell secretion of glucagon in response to infused L-arginine.	Arginine	101-111	islet amyloid polypeptide	Rattus norvegicus	24-30
9005972-6	1997	Plasma glucagon measurements taken during and after the arginine challenge showed that compared with saline infusions, amylin administration dose-dependently suppressed the glucagon response to arginine by a maximum of 62% (incremental area under the curve [AUC] 0 to 60 minutes) with a plasma amylin EC50 of 18 pmol/L +/- 0.3 log units.	Arginine	56-64	islet amyloid polypeptide	Rattus norvegicus	119-125
9005972-6	1997	Plasma glucagon measurements taken during and after the arginine challenge showed that compared with saline infusions, amylin administration dose-dependently suppressed the glucagon response to arginine by a maximum of 62% (incremental area under the curve [AUC] 0 to 60 minutes) with a plasma amylin EC50 of 18 pmol/L +/- 0.3 log units.	Arginine	194-202	islet amyloid polypeptide	Rattus norvegicus	119-125
9005972-7	1997	These data indicate that amylin potently inhibits arginine-stimulated glucagon secretion.	Arginine	50-58	islet amyloid polypeptide	Rattus norvegicus	25-31
9297265-1	1997	The activity of NO-synthase and formation of NO (EDRF) were assessed by an increase in the activity of NO-dependent hyanilate cyclase in response to L-arginine in vitro in platelets of 61 pregnant females (39, 8 14 with essential hypertension, preeclampsia and healthy controls, respectively) and in 9 hypertensive nonpregnant females.	Arginine	149-159	alpha hemoglobin stabilizing protein	Homo sapiens	49-53
9000287-4	1996	However, following initial transient increases in PAP and PVR in the ARGININE group, subsequent pulmonary vasodilation gradually reduced PVR, and thus PAP, in spite of the ongoing elevation of BF through the left lung.	Arginine	69-77	PVR cell adhesion molecule	Homo sapiens	58-61
9027334-2	1996	To learn how residues 94-96 (Arg-Arg-Ser) influence LHR binding, we studied the effects of replacing them on the LH and FSH activities of a bifunctional hCG analog in which residues 101-109 were derived from FSH.	Arginine	29-32	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	52-55
9027334-2	1996	To learn how residues 94-96 (Arg-Arg-Ser) influence LHR binding, we studied the effects of replacing them on the LH and FSH activities of a bifunctional hCG analog in which residues 101-109 were derived from FSH.	Arginine	33-36	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	52-55
8909322-4	1996	RESULTS: One of these kindred"s carried both Hirschsprung"s disease and MEN 2A in conjunction with a cysteine-to-arginine substitution of codon 620 of the RET gene.	Arginine	113-121	ret proto-oncogene	Homo sapiens	155-158
9129159-4	1996	These were a medium hydrophobic residue (Leu or Met) for HLA-A*0201, a basic residue (Arg or Lys) for HLA-B*2705; a small hydrophobic residue (Val) for HLA-A*6801, an acidic residue (Glu) for HLA-B*4001 and a bulky residue (Tyr) for H-2K(d).	Arginine	86-89	major histocompatibility complex, class I, B	Homo sapiens	102-107
8923475-3	1996	We have studied the activity of the arginine biosynthetic enzymes argininosuccinate synthetase and argininosuccinate lyase in dexamethasone and/or dibutyryl cyclic AMP treated rat astrocyte cultures.	Arginine	36-44	argininosuccinate lyase	Rattus norvegicus	99-122
9772350-0	1996	Crystal structure of (L-Arg)-B0 bovine insulin at 0.21 nm resolution.	Arginine	21-27	insulin	Bos taurus	39-46
9772350-1	1996	The crystal structure of (L-Arg)-B0 bovine insulin has been determined, using data to 0.21 nm and atomic parameters of 2Zn porcine insulin as a starting model, by the difference.	Arginine	25-31	insulin	Bos taurus	43-50
9772350-1	1996	The crystal structure of (L-Arg)-B0 bovine insulin has been determined, using data to 0.21 nm and atomic parameters of 2Zn porcine insulin as a starting model, by the difference.	Arginine	25-31	insulin	Bos taurus	131-138
8798625-8	1996	In addition, dexamethasone also inhibited cytokine induction in CMEC of argininosuccinate synthase, the rate-limiting enzyme for the de novo synthesis of arginine from citrulline.	Arginine	154-162	argininosuccinate synthase 1	Homo sapiens	72-98
8816800-9	1996	The dU2AF38 protein is highly homologous to hU2AF35 containing a conserved central arginine- and serine-rich (RS) domain.	Arginine	83-91	U2 small nuclear riboprotein auxiliary factor 38	Drosophila melanogaster	4-11
8816800-9	1996	The dU2AF38 protein is highly homologous to hU2AF35 containing a conserved central arginine- and serine-rich (RS) domain.	Arginine	83-91	U2 small nuclear RNA auxiliary factor 1	Homo sapiens	44-51
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Arginine	98-101	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Arginine	102-105	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Arginine	102-105	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8877818-2	1996	The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).	Arginine	102-105	thyrotropin-releasing hormone L homeolog	Xenopus laevis	69-72
8902879-6	1996	These results demonstrate that TNF-alpha stimulates L-arginine transport in endothelial cells by selectively inducing the expression of CAT-2 mRNA.	Arginine	52-62	tumor necrosis factor	Bos taurus	31-40
8902879-7	1996	The capacity of TNF-alpha to stimulate the expression of CAT-2 protein may provide an important mechanism by which increases in substrate are provided to endothelial cells during periods of elevated L-arginine metabolism.	Arginine	199-209	tumor necrosis factor	Bos taurus	16-25
8765374-4	1996	Ten different types of mutations were identified in the MEN 2A/FMTC families (620 Cys--&gt;Arg, 618 Cys--&gt;Ser, Gly, 611 Cys--&gt;Tyr; 634 Cys--&gt;Arg, Tyr, Trp, Phe, Ser, Gly) and all 6 MEN 2B families had a 918 Met--&gt;Thr point mutation.	Arginine	91-94	ret proto-oncogene	Homo sapiens	56-62
8844845-0	1996	Crystal structures of the active site mutant (Arg-243--&gt;Ala) in the T and R allosteric states of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli.	Arginine	46-49	fructose-bisphosphatase 1	Sus scrofa	111-138
8844845-1	1996	The active site of pig kidney fructose-1,6-bisphosphatase (EC 3.1.3.11) is shared between subunits, Arg-243 of one chain interacting with fructose-1,6-bisphosphate or fructose-2,6-bisphosphate in the active site of an adjacent chain.	Arginine	100-103	fructose-bisphosphatase 1	Sus scrofa	30-57
8844845-6	1996	The differences in kinetic properties of the mutant enzyme indicate the key importance of Arg-243 in the function of fructose-1,6-bisphosphatase.	Arginine	90-93	fructose-bisphosphatase 1	Sus scrofa	117-144
8806499-3	1996	The possibility of direct interaction between dsRNA and the arginine and lysine-rich region of PKR (residues 54-74) was examined using synthetic peptides.	Arginine	60-68	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	95-98
8663387-10	1996	However, beta3 differs from beta1 by the loss of the electrostatic interaction between the NAD(H) pyrophosphate and the Arg-369 side chain.	Arginine	120-123	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	9-14
8663387-13	1996	Thus, the Arg-369 --&gt; Cys substitution of beta3 isoenzyme destabilizes the interaction between coenzyme and beta3 alcohol dehydrogenase.	Arginine	10-13	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	45-50
8663387-13	1996	Thus, the Arg-369 --&gt; Cys substitution of beta3 isoenzyme destabilizes the interaction between coenzyme and beta3 alcohol dehydrogenase.	Arginine	10-13	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	111-116
8695792-2	1996	An arginine to cysteine (R129C) mutation of the extracytoplasmic domain of the murine EpoR leads to Epo-independent growth in transduced cells (cEpoR).	Arginine	3-11	erythropoietin receptor	Mus musculus	86-90
8695792-2	1996	An arginine to cysteine (R129C) mutation of the extracytoplasmic domain of the murine EpoR leads to Epo-independent growth in transduced cells (cEpoR).	Arginine	3-11	erythropoietin	Mus musculus	86-89
8663088-7	1996	Interestingly, the cochaperone DnaJ attenuates the interaction of DnaK with hydrophobic amino acids while strengthening its interaction with arginine or lysine.	Arginine	141-149	DnaJ	Escherichia coli	31-35
8635238-3	1996	Treatment of BASMCs with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta) resulted in a significant increase in L-arginine transport (approximately 20%) and in the induction of NO release.	Arginine	137-147	tumor necrosis factor	Bos taurus	25-52
8635238-3	1996	Treatment of BASMCs with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1 beta (IL-1 beta) resulted in a significant increase in L-arginine transport (approximately 20%) and in the induction of NO release.	Arginine	137-147	tumor necrosis factor	Bos taurus	54-63
8635238-5	1996	In contrast, incubation of BAECs with TNF-alpha or LPS strikingly enhanced L-arginine uptake (2.5-fold), whereas IL-1 beta and IFN-gamma had no effect.	Arginine	75-85	tumor necrosis factor	Bos taurus	38-47
9373320-13	1996	However, when expressed together with the consensus motif His-Arg, as in HRWWXXXX or in HRXKWWXX, binding of these peptides to Fab 2925 increased as compared to peptides expressing the His-Arg motif only.	Arginine	62-65	FA complementation group B	Homo sapiens	127-130
9373320-13	1996	However, when expressed together with the consensus motif His-Arg, as in HRWWXXXX or in HRXKWWXX, binding of these peptides to Fab 2925 increased as compared to peptides expressing the His-Arg motif only.	Arginine	189-192	FA complementation group B	Homo sapiens	127-130
8767485-1	1996	Lactoferrin inhibits the hepatic uptake of lipoprotein remnants, and we showed earlier that arginine residues of lactoferrin are involved.	Arginine	92-100	lactotransferrin	Rattus norvegicus	113-124
8767485-2	1996	In this study, lactoferrin was treated with aminopeptidase-M (APM), which resulted in removal of 14 N-terminal amino acids, including 4 clustered arginines at positions 2-5 (APM-lactoferrin).	Arginine	146-155	lactotransferrin	Rattus norvegicus	15-26
8767485-2	1996	In this study, lactoferrin was treated with aminopeptidase-M (APM), which resulted in removal of 14 N-terminal amino acids, including 4 clustered arginines at positions 2-5 (APM-lactoferrin).	Arginine	146-155	alanyl aminopeptidase, membrane	Rattus norvegicus	44-60
8767485-10	1996	The Arg/Lys sequence at position 25-30, which resembles the binding site of apoE, may mediate the high affinity binding of lactoferrin and block the binding of beta-VLDL to the remnant receptor efficiently.	Arginine	4-7	lactotransferrin	Rattus norvegicus	123-134
8647869-2	1996	The RMT1 (protein-arginine methyltransferase), formerly ODP1, gene product encodes a 348-residue polypeptide of 39.8 kDa that catalyzes both the NG-mono- and NG, NG-asymmetric dimethylation of arginine residues in a variety of endogenous yeast polypeptides.	Arginine	18-26	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	4-8
8647869-2	1996	The RMT1 (protein-arginine methyltransferase), formerly ODP1, gene product encodes a 348-residue polypeptide of 39.8 kDa that catalyzes both the NG-mono- and NG, NG-asymmetric dimethylation of arginine residues in a variety of endogenous yeast polypeptides.	Arginine	18-26	protein-arginine omega-N methyltransferase HMT1	Saccharomyces cerevisiae S288C	56-60
8626701-4	1996	Mutations of Arg-124, Ser-126, Lys-128, and Gln-129 inhibited both phosphorylation and TCR down-regulation, whereas mutation of Asp-127 only inhibited down-regulation.	Arginine	13-16	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	87-90
8649853-7	1996	Analysis of the mechanism of association indicated that the ArgBP1 SH3 domain binds to a C-terminal Arg SH3-binding site, and that an N-terminal ArgBP1 proline-rich sequence binds to the Arg SH3 domain.	Arginine	100-103	abl interactor 2	Homo sapiens	60-66
8649853-9	1996	The similarity of the ArgBP1 expression pattern and subcellular localization to those of Arg and the potential for a highly specific and potentially strong association mediated by two pairs of SH3 domain/proline-rich motif interactions, suggest that ArgBP1 is likely to be a regulator and/or effector of Arg function.	Arginine	22-25	abl interactor 2	Homo sapiens	250-256
8649853-9	1996	The similarity of the ArgBP1 expression pattern and subcellular localization to those of Arg and the potential for a highly specific and potentially strong association mediated by two pairs of SH3 domain/proline-rich motif interactions, suggest that ArgBP1 is likely to be a regulator and/or effector of Arg function.	Arginine	89-92	abl interactor 2	Homo sapiens	250-256
8649854-7	1996	The point mutation (ATG50 to AGG) or deletion of codon 50 removes a methionine and increases the stretch of arginines encoded by the AGG repeats in the ARP gene.	Arginine	108-117	cysteine rich secretory protein 1	Homo sapiens	152-155
8722626-7	1996	The effect of fibronectin was inhibited by hexapeptides that contained the integrin-recognizing Arg-Gly-Asp sequence.	Arginine	96-99	fibronectin 1	Mus musculus	14-25
8860654-1	1996	The adult isoform of human cardiac troponin T (TnT) contains 288 amino acids, 14 of which (4.9%) are encoded by the rarely used arginine codons (12 AGG, 2 AGA) in Escherichia coli genes.	Arginine	128-136	troponin T1, slow skeletal type	Homo sapiens	47-50
8860654-6	1996	As suspected, a 10-fold increase in TnT expression was obtained when one pair of the rare arginine codons was replaced and a 40-fold increase was achieved when both pairs of the rare codons were replaced.	Arginine	90-98	troponin T1, slow skeletal type	Homo sapiens	36-39
8608946-8	1996	The arginine/serine-rich domain (RS domain) of HRH1, which is missing in Prp22, confers a nuclear localization signal, and appears to facilitate the interaction of HRH1 with the spliceosome.	Arginine	4-12	histamine receptor H1	Homo sapiens	47-51
8608946-8	1996	The arginine/serine-rich domain (RS domain) of HRH1, which is missing in Prp22, confers a nuclear localization signal, and appears to facilitate the interaction of HRH1 with the spliceosome.	Arginine	4-12	DEAH-box helicase 8	Homo sapiens	73-78
8608946-8	1996	The arginine/serine-rich domain (RS domain) of HRH1, which is missing in Prp22, confers a nuclear localization signal, and appears to facilitate the interaction of HRH1 with the spliceosome.	Arginine	4-12	histamine receptor H1	Homo sapiens	164-168
8635221-0	1996	Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M. Both human plasma carboxypeptidase N (CPN) and membrane-bound carboxypeptidase M (CPM) released the C-terminal arginine (alpha-Arg141) of the alpha chain of human adult hemoglobin.	Arginine	200-208	carboxypeptidase M	Homo sapiens	151-169
8639267-7	1996	The Surf-6 long open reading frame encodes a novel highly basic polypeptide of 355 amino acids (28% Arg and Lys).	Arginine	100-103	surfeit gene 6	Mus musculus	4-10
8615753-11	1996	In addition, rat kidney GST 1 has an arginine and a valine residue at positions 151 and 207 respectively.	Arginine	37-45	carbohydrate sulfotransferase 1	Rattus norvegicus	24-29
8615753-13	1996	Further analyses indicate that rat liver GST 1 also has a C-terminal phenylalanine deletion, and an arginine and a valine residue at positions 151 and 207 respectively.	Arginine	100-108	carbohydrate sulfotransferase 1	Rattus norvegicus	41-46
8617791-3	1996	Mutations of the cysteine or the arginine residues in the active site motif abolished the Cdc25 phosphatase activity.	Arginine	33-41	cell division cycle 25C	Homo sapiens	90-95
8549863-6	1996	Used alone or in combination, TNF and IFN significantly enhanced the activity of inducible nitric oxide synthase as determined by measuring the conversion of 14C-labeled arginine to 14C-labeled citrulline and nitric oxide.	Arginine	170-178	interferon gamma	Rattus norvegicus	38-41
8835508-4	1996	A characteristic of HLAB27 is the binding of peptides having arginine at position 2.	Arginine	61-69	major histocompatibility complex, class I, B	Homo sapiens	20-26
8835509-9	1996	All peptides found were nonameres with arginine (Arg) at position 2 which is in agreement with the previously described HLA-B27 peptide binding motif.	Arginine	39-47	major histocompatibility complex, class I, B	Homo sapiens	120-127
8835509-9	1996	All peptides found were nonameres with arginine (Arg) at position 2 which is in agreement with the previously described HLA-B27 peptide binding motif.	Arginine	49-52	major histocompatibility complex, class I, B	Homo sapiens	120-127
18475725-1	1996	The role of the L-arginine-nitric oxide metabolic pathway was explored for interleukin-2-induced proliferation in the cytotoxic T lymphocyte clone CTLL-2.	Arginine	16-26	interleukin 2	Mus musculus	75-88
18475725-4	1996	Furthermore, intermedial concentrations of Larginine and exogenous nitric oxide donors were found for achieving optimal IL2-induced proliferation of CTLL-2.	Arginine	43-52	interleukin 2	Mus musculus	120-123
8600990-1	1995	The review summarizes contemporary views on the biological role, levels and mechanisms of regulation of carboxypeptidase H--the exopeptidase of secretory vesicles removing arginine and lysine residues from C-termini of peptides.	Arginine	172-180	carboxypeptidase E	Homo sapiens	104-122
8602887-4	1995	The presence of an arginine residue within the N-terminal part of the mature human GM-CSF was shown to hinder the proper processing and translocation of the precursor through periplasmic membrane.	Arginine	19-27	colony stimulating factor 2	Homo sapiens	83-89
8719885-5	1995	Adding the RGD peptide, Gly-Arg-Gly-Glu-Ser-Pro to the medium of sparsely plated cells resulted in rapid reductions in cell spreading concomitant with dose-dependent decreases in ornithine decarboxylase activity and putrescine uptake.	Arginine	28-31	ornithine decarboxylase 1	Rattus norvegicus	179-202
7494262-10	1995	Since the transactivation response region element is known to interact specifically with arginine residues in the Tat protein, these results suggest that the XBE binds to the arginine-rich RNA-binding domain of Rex in a similar manner.	Arginine	89-97	p27	Human T-cell leukemia virus type I	211-214
7583591-5	1995	Furthermore, L-NAME-induced P-selectin expression was significantly attenuated by either L-arginine, 8-bromo-cGMP, or sodium nitroprusside (SNP).	Arginine	89-99	selectin P	Homo sapiens	28-38
7583591-7	1995	L-NAME, thrombin, and PMA also significantly increased polymorphonuclear leukocyte adherence to the coronary artery endothelium, an effect that was significantly attenuated by the anti-P-selectin monoclonal antibody PB1.3 or by UCN-01, L-arginine, 8-bromo-cGMP or SNP but not by D-arginine or he nonblocking anti-P-selectin monoclonal antibody NBP1.6.	Arginine	236-246	selectin P	Homo sapiens	185-195
8585320-1	1995	Repression or induction of the genes involved in arginine biosynthesis or catabolism, respectively, both require participation of the ArgRp/Mcm1p regulatory complex.	Arginine	49-57	transcription factor MCM1	Saccharomyces cerevisiae S288C	140-145
8585320-3	1995	To define more precisely the sequence and position requirements of the ARC element, we have now characterized by mutagenesis the promoter elements of the arginine-repressible ARG1 and ARG8 genes.	Arginine	154-162	argininosuccinate synthase	Saccharomyces cerevisiae S288C	175-179
8585320-3	1995	To define more precisely the sequence and position requirements of the ARC element, we have now characterized by mutagenesis the promoter elements of the arginine-repressible ARG1 and ARG8 genes.	Arginine	154-162	acetylornithine transaminase	Saccharomyces cerevisiae S288C	184-188
8585320-4	1995	We also identify a functional ARC in the CPA1 promoter, thereby confirming, in agreement with our previous mRNA pulse-labelling data, the participation of a transcriptional component in the arginine regulation of that gene otherwise submitted to a translational regulation.	Arginine	190-198	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Saccharomyces cerevisiae S288C	41-45
8585320-5	1995	From the 12 ARC elements now characterized, we have derived a consensus sequence and show that such a synthetic element is able to mediate ArgRp/Mcm1p-dependent arginine regulation.	Arginine	161-169	transcription factor MCM1	Saccharomyces cerevisiae S288C	145-150
7479068-5	1995	The epitope recognized by mAb U1 70K was previously shown to be a repeating arginine/aspartate (RD) dipeptide.	Arginine	76-84	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	30-36
8547593-7	1995	ADC and iNOS enzymes synthesizing distinct bioactive products from L-arginine, may be reciprocally regulated.	Arginine	67-77	antizyme inhibitor 2	Homo sapiens	0-3
8548301-2	1995	The 3,4-DAP-evoked [3H]overflow was enhanced by the NO synthase substrate L-arginine, but not by D-arginine; it was reduced by the NO synthase inhibitor NG-nitro-L-arginine, which also antagonized the effects of L-arginine.	Arginine	74-84	death-associated protein	Rattus norvegicus	8-11
8548301-2	1995	The 3,4-DAP-evoked [3H]overflow was enhanced by the NO synthase substrate L-arginine, but not by D-arginine; it was reduced by the NO synthase inhibitor NG-nitro-L-arginine, which also antagonized the effects of L-arginine.	Arginine	162-172	death-associated protein	Rattus norvegicus	8-11
7669582-6	1995	Sequencing of the subcloned mutant cDNA revealed a missense mutation from TGG to CGG at codon 133 of the nm23-H2 gene, resulting in a change from Trp to Arg.	Arginine	153-156	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	105-112
7642961-1	1995	The immunocytochemical application of a monoclonal antibody (MAb) against the Arg-Arg region at the junction of the C-peptide and the insulin beta-chain of the human proinsulin molecule on rat pancreatic tissue resulted in positive immunogold labeling over the insulin- as well as the glucagon-secreting cells.	Arginine	78-81	insulin	Bos taurus	169-176
7642961-1	1995	The immunocytochemical application of a monoclonal antibody (MAb) against the Arg-Arg region at the junction of the C-peptide and the insulin beta-chain of the human proinsulin molecule on rat pancreatic tissue resulted in positive immunogold labeling over the insulin- as well as the glucagon-secreting cells.	Arginine	82-85	insulin	Bos taurus	134-141
7565622-4	1995	The inactive NPY carboxyl-terminal pentapeptide (Thr-Arg-Gln-Arg-Tyr-NH2; IC50 &gt; 100 microM) was modified by replacing threonine with an aromatic amino acid and glutamine with leucine.	Arginine	53-56	neuropeptide Y	Homo sapiens	13-16
7565622-4	1995	The inactive NPY carboxyl-terminal pentapeptide (Thr-Arg-Gln-Arg-Tyr-NH2; IC50 &gt; 100 microM) was modified by replacing threonine with an aromatic amino acid and glutamine with leucine.	Arginine	61-64	neuropeptide Y	Homo sapiens	13-16
7565622-6	1995	The structure-affinity data suggest that these peptides may represent a noncontinuous epitope containing the amino-terminal tyrosine and the carboxyl-terminal residues Arg-35 and Tyr-36 of NPY.	Arginine	168-171	neuropeptide Y	Homo sapiens	189-192
8933822-2	1995	Enhancement of A-NKP 1, 2, and 3 proteolytic activities (cleaving after Arg, Phe and Pro) in response to interleukin-2.	Arginine	72-75	interleukin 2	Rattus norvegicus	105-118
7636245-6	1995	Different from these receptors, CD97 has an extended extracellular region of 433 amino acids that possesses three N-terminal epidermal growth factor-like domains, two of them with a calcium-binding site, and a single Arg-Gly-Asp (RGD) motif.	Arginine	217-220	adhesion G protein-coupled receptor E5	Homo sapiens	32-36
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Arginine	37-40	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	13-19
7642551-6	1995	Mutations at FKBP12 residues Asp-37, Arg-42, His-87, and Ile-90 decrease calcineurin affinity of the mutant FKBP12.FK506 complex by as much as 2600-fold in the case of I90K.	Arginine	37-40	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	108-114
7609750-4	1995	RESULTS: A missense mutation was identified in the gene for the beta 3-adrenergic receptor that results in the replacement of tryptophan by arginine (Trp64Arg) in the first intracellular loop of the receptor.	Arginine	140-148	adrenoceptor beta 3	Homo sapiens	64-90
7598936-7	1995	Cells expressing Arg at codon 16 (Arg16) traditionally referred to as wild-type, underwent 77.8 +/- 8.1% downregulations of beta 2AR following prolonged (24-h) exposure to the beta 2AR agonist isoproterenol (10 microM).	Arginine	17-20	adenosine A2a receptor	Homo sapiens	124-132
7598936-7	1995	Cells expressing Arg at codon 16 (Arg16) traditionally referred to as wild-type, underwent 77.8 +/- 8.1% downregulations of beta 2AR following prolonged (24-h) exposure to the beta 2AR agonist isoproterenol (10 microM).	Arginine	17-20	adenosine A2a receptor	Homo sapiens	176-184
7619045-11	1995	These results demonstrate that ADP-ribosylation of arginine residues just N-terminal to the site phosphorylated by PKA modulate PFK-2 activity by an electrostatic and/or steric mechanism which does not involved uncoupling of N- and C-terminal interactions as seen with cAMP-dependent phosphorylation.	Arginine	51-59	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	128-133
7768927-6	1995	Both SPC2 and SPC3 participate in the processing of prohormones at dibasic cleavage sites, typically Lys-Arg or Arg-Arg.	Arginine	105-108	proprotein convertase subtilisin/kexin type 2	Homo sapiens	5-9
7768927-6	1995	Both SPC2 and SPC3 participate in the processing of prohormones at dibasic cleavage sites, typically Lys-Arg or Arg-Arg.	Arginine	105-108	proprotein convertase subtilisin/kexin type 1	Homo sapiens	14-18
7768927-6	1995	Both SPC2 and SPC3 participate in the processing of prohormones at dibasic cleavage sites, typically Lys-Arg or Arg-Arg.	Arginine	112-115	proprotein convertase subtilisin/kexin type 2	Homo sapiens	5-9
7768927-6	1995	Both SPC2 and SPC3 participate in the processing of prohormones at dibasic cleavage sites, typically Lys-Arg or Arg-Arg.	Arginine	112-115	proprotein convertase subtilisin/kexin type 1	Homo sapiens	14-18
7550111-4	1995	Similar enhancement was observed when the macrophages were plated on a substrate pre-coated with Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) peptide, an adhesive sequence of FN involved in binding to the cells, but not with the control Gly-Arg-Gly-Glu-Ser-Pro (GRGESP) peptide.	Arginine	101-104	fibronectin 1	Mus musculus	163-165
7797079-3	1995	The carboxy-terminal portion of U1-70K-encompassing repeats of Arg/Ser, Arg/Glu, and Arg/Asp localizes to the nucleus independently of U1 RNA and was responsible for these inhibitory effects.	Arginine	63-66	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	32-38
7797079-3	1995	The carboxy-terminal portion of U1-70K-encompassing repeats of Arg/Ser, Arg/Glu, and Arg/Asp localizes to the nucleus independently of U1 RNA and was responsible for these inhibitory effects.	Arginine	72-75	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	32-38
7797079-3	1995	The carboxy-terminal portion of U1-70K-encompassing repeats of Arg/Ser, Arg/Glu, and Arg/Asp localizes to the nucleus independently of U1 RNA and was responsible for these inhibitory effects.	Arginine	72-75	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	32-38
7641023-16	1995	Furthermore, EGF and TGF alpha preferentially stimulate L-arginine uptake via the Na(+)-dependent transporter, ostensibly to accommodate for the mitogenic stimulus.	Arginine	56-66	epidermal growth factor	Homo sapiens	13-16
7622024-1	1995	The effect of the expression of the exogenous human mutant p53 (Arg--&gt;His in codon 273) on the amplification rate of the gene dhfr in permissive Rat-1 and LIM1215 cells was studied.	Arginine	64-67	dihydrofolate reductase	Homo sapiens	129-133
7590907-1	1995	The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized.	Arginine	40-43	interleukin 1 alpha	Homo sapiens	136-159
7748897-2	1995	In the mollusc myoglobin, in which His-E7 is replaced by Val, the guanidino group of Arg-E10 serves as an alternative hydrogen-bond donor to the bound ligand.	Arginine	85-88	myoglobin	Homo sapiens	15-24
7748897-8	1995	These results confirm that the presence of steric hindrance between these bulky ligands and the long and bulky side chain of Arg-E10 in the distal pocket of the mollusc myoglobin.	Arginine	125-128	myoglobin	Homo sapiens	169-178
7536925-3	1995	Src-SH3-specific binding uses a sequence of 7 aa of the consensus RPLPXXP, in which the N-terminal arginine is very important.	Arginine	99-107	Rous sarcoma oncogene	Mus musculus	0-3
7713922-3	1995	Arg-DHFR, a modified dihydrofolate reductase bearing an N-terminal arginine (destabilizing residue in the N-end rule), is short lived in ATP-supplemented reticulocyte extract.	Arginine	67-75	dihydrofolate reductase	Homo sapiens	4-8
7535743-3	1995	ITIH1*1 was characterized by GAG (Glu) at codon 551 and CAG (Gln) at codon 561, ITIH1*2, by GTG (Val) and CGG (Arg), and ITIH1*3, by GAG (Glu) and CGG (Arg).	Arginine	111-114	inter-alpha-trypsin inhibitor heavy chain 1	Homo sapiens	0-5
7535743-3	1995	ITIH1*1 was characterized by GAG (Glu) at codon 551 and CAG (Gln) at codon 561, ITIH1*2, by GTG (Val) and CGG (Arg), and ITIH1*3, by GAG (Glu) and CGG (Arg).	Arginine	152-155	inter-alpha-trypsin inhibitor heavy chain 1	Homo sapiens	0-5
7893664-2	1995	The serpins antithrombin, protease nexin 1, and alpha 1-antitrypsin with a reactive-center arginine (Arg-alpha 1-antitrypsin) were found to inhibit the sperm protease acrosin with varying efficiency.	Arginine	91-99	serpin family C member 1	Homo sapiens	12-24
7893664-2	1995	The serpins antithrombin, protease nexin 1, and alpha 1-antitrypsin with a reactive-center arginine (Arg-alpha 1-antitrypsin) were found to inhibit the sperm protease acrosin with varying efficiency.	Arginine	91-99	acrosin	Homo sapiens	167-174
7893664-5	1995	In particular, only 2.7% of protease nexin 1 molecules interacting with acrosin formed stable complexes with the enzyme at 37 degrees C and this value decreased to 0.03% at 12 degrees C. N-terminal sequence analysis indicated that acrosin had cleaved protease nexin 1 at its reactive-center Arg-Ser bond.	Arginine	291-294	acrosin	Homo sapiens	72-79
7893664-5	1995	In particular, only 2.7% of protease nexin 1 molecules interacting with acrosin formed stable complexes with the enzyme at 37 degrees C and this value decreased to 0.03% at 12 degrees C. N-terminal sequence analysis indicated that acrosin had cleaved protease nexin 1 at its reactive-center Arg-Ser bond.	Arginine	291-294	acrosin	Homo sapiens	231-238
7533186-8	1995	Importantly, we found a single nucleotide difference (C --> T) within the extracellular domain exon 1-encoding region of hFc gamma RIA in nonresponders, resulting in the change of codon 92 (encoding an arginine) into a termination codon.	Arginine	202-210	Fc gamma receptor Ia	Homo sapiens	121-134
7533537-9	1995	Within domain 18-24, arginine 21 is required for inhibition of t-PA and alpha 2M* binding as well as for the direct binding of amino-terminal constructs to LRP.	Arginine	21-29	alpha-2-macroglobulin	Homo sapiens	72-80
7868892-4	1995	Changes of arginine 264, the anchor amino acid for HLA-B27, to lysine or glycine resulted in infectious HIV-1 variants.	Arginine	11-19	major histocompatibility complex, class I, B	Homo sapiens	51-58
7696141-2	1995	A CYP17 arginine-rich domain, including Arg346, Arg361 and Arg363, that has previously been shown to be important to CYP17 catalytic activity, is conserved in this HSD structural element between two HSD domains known to be important to C19 steroid binding.	Arginine	8-16	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	2-7
7696141-2	1995	A CYP17 arginine-rich domain, including Arg346, Arg361 and Arg363, that has previously been shown to be important to CYP17 catalytic activity, is conserved in this HSD structural element between two HSD domains known to be important to C19 steroid binding.	Arginine	8-16	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	117-122
7857302-2	1995	The labeled site was identified as Arg-589 (this corresponds to amino acid residue 385 of hRAR alpha) or a residue in its vicinity.	Arginine	35-38	retinoic acid receptor alpha	Homo sapiens	90-100
7540635-6	1995	We now report that the Arg-Gly-Asp-mimetics specifically inhibited the binding of murine T cells to fibronectin, but did not affect the proliferative response of these cells in vitro.	Arginine	23-26	fibronectin 1	Mus musculus	100-111
7773301-4	1995	The T416--&gt;C mutation in exon 3 of CYP2C9 (Cys144--&gt;Arg) creates an Ava II site.	Arginine	58-61	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	38-44
7846628-4	1995	We hypothesize that lipopolysaccharide stimulation of plasma membrane L-arginine transport is mediated via an autocrine cytokine loop involving TNF and IL-1.	Arginine	70-80	interleukin 1 alpha	Homo sapiens	152-156
7846628-7	1995	RESULTS: Lipopolysaccharide, IL-1, and TNF all increased both Na+-dependent and Na+-independent carrier-mediated L-arginine transport in a fashion that was both time and dose dependent.	Arginine	113-123	interleukin 1 alpha	Homo sapiens	29-33
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	53-63	interleukin 1 alpha	Homo sapiens	115-119
7846628-11	1995	CONCLUSIONS: The marked increase in carrier-mediated L-arginine transport activity produced by lipopolysaccharide, IL-1, and TNF may represent an adaptive response by the pulmonary endothelium to support arginine-dependent biosynthetic pathways during sepsis.	Arginine	55-63	interleukin 1 alpha	Homo sapiens	115-119
7846628-12	1995	Furthermore, lipopolysaccharide stimulation of arginine transport is mediated in part through an autocrine mechanism involving IL-1 and TNF.	Arginine	47-55	interleukin 1 alpha	Homo sapiens	127-131
7825573-5	1995	The deficiency is assigned to the XP-D complementation group, and we have identified two causative mutations in the XPD gene: a gly-->arg change at amino acid 675 in the allele inherited from the patient"s mother and a -1 frameshift at amino acid 669 in the allele inherited from his father.	Arginine	134-137	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	34-38
7825573-5	1995	The deficiency is assigned to the XP-D complementation group, and we have identified two causative mutations in the XPD gene: a gly-->arg change at amino acid 675 in the allele inherited from the patient"s mother and a -1 frameshift at amino acid 669 in the allele inherited from his father.	Arginine	134-137	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	116-119
7529997-1	1995	In the conversion of bovine plasminogen to bovine plasmin not only the expected urokinase-catalysed cleavage of Arg-557-Val-558, and the following autocatalytic cleavage separating the N-terminal peptide 1-77 from the heavy chain of plasmin, but also a cleavage at Arg-342-Met-343 between kringles 3 and 4 is seen.	Arginine	112-115	plasminogen	Bos taurus	28-35
7529997-1	1995	In the conversion of bovine plasminogen to bovine plasmin not only the expected urokinase-catalysed cleavage of Arg-557-Val-558, and the following autocatalytic cleavage separating the N-terminal peptide 1-77 from the heavy chain of plasmin, but also a cleavage at Arg-342-Met-343 between kringles 3 and 4 is seen.	Arginine	112-115	plasminogen	Bos taurus	50-57
8745708-2	1995	The molecular abnormality responsible for the resistance to activated protein C is due to a mutation of an amino acid in the 506 position (Arg--&gt;Gln) at the level of the factor V, designated under the name of factor V Leiden.	Arginine	139-142	coagulation factor V	Homo sapiens	212-227
7715823-7	1994	The facilitatory effect of IFN-gamma was mediated, at least in part, by the activation of the L-arginine-nitric oxide pathway.	Arginine	94-104	interferon gamma	Rattus norvegicus	27-36
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	interleukin 1 alpha	Homo sapiens	193-212
7986159-2	1994	Bacterial lipopolysaccharide (endotoxin) (LPS) stimulates carrier-mediated L-arginine transport in porcine pulmonary artery endothelial cells (PAECs) through an autocrine pathway that involves interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF-alpha).	Arginine	75-85	interleukin 1 alpha	Homo sapiens	214-224
7881414-6	1994	In three families, both HSCR and MEN 2A were associated with a single Cys-->Arg mutation at either codon 618 or 620 of RET.	Arginine	76-79	ret proto-oncogene	Homo sapiens	33-39
7881414-6	1994	In three families, both HSCR and MEN 2A were associated with a single Cys-->Arg mutation at either codon 618 or 620 of RET.	Arginine	76-79	ret proto-oncogene	Homo sapiens	119-122
7537125-7	1994	External calcium ion and temperature dependence of adhesion together with the observation that RGD (Arg, Gly, Asp)--containing peptide blocked cell binding to FN suggests that FC epsilon RI crosslinking-induced adhesion potentiation involves an integrin type receptor on cell surface.	Arginine	100-103	fibronectin 1	Mus musculus	159-161
7971997-7	1994	Deletion analysis of p21 indicated that the sequences essential for inhibition of RSV LTR function include the previously identified ARg/Ser-rich region and zinc finger-like motif.	Arginine	133-136	H3 histone pseudogene 16	Homo sapiens	21-24
7525260-3	1994	Release of EGF into the milk requires the hydrolysis of the EGF precursor at Arg-X cleavage sites.	Arginine	77-80	epidermal growth factor	Mus musculus	60-63
7896732-1	1994	The gene for rat argininosuccinate lyase (AL), which catalyzes the last step of arginine biosynthesis, is expressed in many tissues, though its expression is much higher in the liver where the enzyme is involved in the ornithine cycle (urea cycle), and moderately higher in the kidney.	Arginine	80-88	argininosuccinate lyase	Rattus norvegicus	17-40
7671126-7	1994	NG-monomethyl-L-arginine monohydrate, an analogue of L-arginine, and arginase inhibited rIFN-gamma-plus-PMA-induced NO production in murine microglial cells.	Arginine	14-24	interferon gamma	Rattus norvegicus	88-98
7937939-1	1994	The Ca2+ permeability and the rectifying properties of the glutamate receptors assembled from the subunits GluR1-GluR4 depend upon a critical Arg in the GluR2 subunit located in a domain that has been proposed to span the membrane.	Arginine	142-145	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	107-112
7919387-8	1994	In addition, AA-induced release of myeloperoxidase, a marker of azurophilic granules, was found to be enhanced in L-arg- (10 mmol/L) pretreated PMNLs.	Arginine	114-119	myeloperoxidase	Rattus norvegicus	35-50
7925973-0	1994	Molecular cloning of Bac7, a proline- and arginine-rich antimicrobial peptide from bovine neutrophils.	Arginine	42-50	cathelicidin-3	Bos taurus	21-25
7925973-1	1994	Bac7 is a 7 kDa proline- and arginine-rich antimicrobial peptide which was purified from bovine neutrophils.	Arginine	29-37	cathelicidin-3	Bos taurus	0-4
8089099-7	1994	Based on these findings and evidence that two transmembrane arginines are important in binding, we developed a three-dimensional model of the TRH receptor binding pocket using molecular modeling and simulation programs.	Arginine	60-69	thyrotropin releasing hormone receptor	Homo sapiens	142-154
7943258-8	1994	Treatment with the NO synthase antagonists NG-monomethyl-L-arginine (1 mM) and N-nitroso-L-arginine (1 mM) induced an L-arginine (1 mM)-dependent decrease in NO2- in control but not in TNF-treated PAEM.	Arginine	57-67	tumor necrosis factor	Bos taurus	185-188
7518750-7	1994	We also report that cytotoxic activities of fresh or IL-2-activated NK cells appear to be dependent on arginine levels in medium.	Arginine	103-111	interleukin 2	Rattus norvegicus	53-57
8027551-5	1994	rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because NG-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM.	Arginine	215-225	interferon gamma	Rattus norvegicus	0-10
7987212-4	1994	Proteolytic removal of the C-terminal arginine of C5a (C5adesArg) reduced spasmogenic potency of rat C5a by only 4-fold compared to a 3,000-fold reduction for human C5adesArg.	Arginine	38-46	complement C5	Rattus norvegicus	50-53
7987212-4	1994	Proteolytic removal of the C-terminal arginine of C5a (C5adesArg) reduced spasmogenic potency of rat C5a by only 4-fold compared to a 3,000-fold reduction for human C5adesArg.	Arginine	38-46	complement C5	Rattus norvegicus	55-58
8043603-7	1994	Characterization of the chimeric enzymes revealed that residues between residues 54-110 and 229-317, namely, Val-55 and/or Ala-81, and Arg-242 and/or Cys-264 of PRS I also contribute to the strong GDP inhibition.	Arginine	135-138	phosphoribosyl pyrophosphate synthetase 1	Rattus norvegicus	161-166
7516470-5	1994	The C-terminal half of the U1-70K protein which was capable of nuclear entry contains two arginine-rich regions, which suggests the existence of a second NLS.	Arginine	90-98	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	27-33
7514170-10	1994	However, induction of IDO activity was observed in murine macrophages when the synthesis of reactive nitrogen species was inhibited, by using arginine-free medium and/or the nitric oxide synthesis inhibitor, NG-monomethyl-L-arginine.	Arginine	142-150	indoleamine 2,3-dioxygenase 1	Mus musculus	22-25
8202378-3	1994	Twelve of the fourteen single-point mutations that give rise to temperature-sensitive (ts) or null phenotypes are located in the portion of the PRP4 gene that corresponds to the beta-transducin-like region of the protein; the remaining two are located in the central portion of the gene, one of them in an arginine-lysine-rich region.	Arginine	306-314	U4/U6-U5 snRNP complex subunit PRP4	Saccharomyces cerevisiae S288C	144-148
8151751-9	1994	Further mutational analyses have demonstrated that a methionine at residue 500 of VP3 and an arginine at residue 502 were both required for CLP formation.	Arginine	93-101	calmodulin like 3	Homo sapiens	140-143
8185227-11	1994	The ratio of bioactivity to enzyme activity for the Arg 163--&gt;Glu mutant was approximately one third of the value obtained for each of the other fusion proteins, indicating that arginine at 163 is functionally important for EPO activity.	Arginine	52-55	erythropoietin	Mus musculus	227-230
8185227-11	1994	The ratio of bioactivity to enzyme activity for the Arg 163--&gt;Glu mutant was approximately one third of the value obtained for each of the other fusion proteins, indicating that arginine at 163 is functionally important for EPO activity.	Arginine	181-189	erythropoietin	Mus musculus	227-230
7926780-3	1994	In the United States 86.4% of scrapie cases occur in Suffolk sheep, and within this breed 49 +/- 6% (+/- S.D., n = 69) of healthy animals carry one or more PrP alleles encoding Arg (R)-171.	Arginine	177-180	major prion protein	Ovis aries	156-159
8063047-0	1994	Amylin tonally regulates arginine-stimulated insulin secretion in rats.	Arginine	25-33	islet amyloid polypeptide	Rattus norvegicus	0-6
7511093-4	1994	Treatment of GT1-1 cells with increasing concentrations of L-arginine, the direct precursor of NO, produced a marked reduction of norepinephrine-stimulated GnRH release despite a lack of effect on basal secretion.	Arginine	59-69	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	13-16
7511093-9	1994	In addition, treatment of GT1-1 cells with both L-arginine analogs produced a significant inhibition of the basal cGMP concentration.	Arginine	48-58	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	26-29
8132543-8	1994	Furthermore, the mutation of an arginine residue in the third zinc finger of NGFI-A, a position which is occupied by a leucine residue in most C2H2 zinc fingers, abolished nuclear localization, but had no effect on DNA binding.	Arginine	32-40	early growth response 1	Homo sapiens	77-83
8185714-2	1994	Stimulated by the present controversy on the identity of L-arginine-derived endothelium-derived relaxing factor (EDRF) experiments were designed to clarify whether or not EDRF is a nitrosyl-iron complex.	Arginine	57-67	alpha hemoglobin stabilizing protein	Homo sapiens	76-111
8185714-2	1994	Stimulated by the present controversy on the identity of L-arginine-derived endothelium-derived relaxing factor (EDRF) experiments were designed to clarify whether or not EDRF is a nitrosyl-iron complex.	Arginine	57-67	alpha hemoglobin stabilizing protein	Homo sapiens	113-117
8005751-3	1994	However, for arginine in protein structures, chi 3 and chi 4 appear to be flexible and can be tuned for optimal anion binding.	Arginine	13-21	chitinase 1	Homo sapiens	45-50
8293561-7	1994	In addition, the peptide GRGDSP blocked adhesion to osteopontin, suggesting that integrins mediate Arg-Gly-Asp-dependent adhesion.	Arginine	99-102	secreted phosphoprotein 1	Homo sapiens	52-63
8169523-6	1994	Mouse apoJ contains six potential N-glycosylation sites, a potential Arg-Ser cleavage site to generate alpha and beta subunits, a cluster of five cysteine residues in each subunit, three putative amphipathic helices, and four potential heparin-binding domains.	Arginine	69-72	clusterin	Mus musculus	6-10
7508126-2	1994	In vitro exposure of murine endothelial cells to various cytokines (interferon gamma, tumor necrosis factor alpha, and interleukin 1 alpha or 1 beta) resulted in their activation to kill schistosomula through an arginine-dependent mechanism involving production of nitric oxide (NO).	Arginine	212-220	interleukin 1 alpha	Mus musculus	119-148
8294404-7	1994	Thus, Arg-403 likely contributes to an important interaction at the actin interface of myosin.	Arginine	6-9	myosin heavy chain 14	Homo sapiens	87-93
8290568-8	1994	Biochemical analysis of one FHC mutant (Arg-249--&gt;Gln) demonstrates that the structures formed by the mutant are solubilized at a lower ionic strength than those formed by wild-type MHC.	Arginine	40-43	low density lipoprotein receptor	Homo sapiens	28-31
8280781-0	1994	Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin.	Arginine	0-3	serpin family C member 1	Homo sapiens	53-65
7903302-1	1993	Lactoferrin inhibits the hepatic uptake of lipoprotein remnants, and we showed earlier that arginine residues of lactoferrin are involved.	Arginine	92-100	lactotransferrin	Rattus norvegicus	113-124
7903302-2	1993	In this study, lactoferrin was treated with aminopeptidase M (APM), which resulted in removal of 14 N-terminal amino acids, including 4 clustered arginine residues at positions 2-5 (APM-lactoferrin).	Arginine	146-154	lactotransferrin	Rattus norvegicus	15-26
7903302-2	1993	In this study, lactoferrin was treated with aminopeptidase M (APM), which resulted in removal of 14 N-terminal amino acids, including 4 clustered arginine residues at positions 2-5 (APM-lactoferrin).	Arginine	146-154	alanyl aminopeptidase, membrane	Rattus norvegicus	44-60
7903302-9	1993	Selective modification of the arginines of APM-lactoferrin with 1,2-cyclohexanedione reduced the liver association by approximately 60% and abolished the capacity of APM-lactoferrin to inhibit the binding of 125I-labeled beta-VLDL in vitro.	Arginine	30-39	lactotransferrin	Rattus norvegicus	47-58
7903302-9	1993	Selective modification of the arginines of APM-lactoferrin with 1,2-cyclohexanedione reduced the liver association by approximately 60% and abolished the capacity of APM-lactoferrin to inhibit the binding of 125I-labeled beta-VLDL in vitro.	Arginine	30-39	lactotransferrin	Rattus norvegicus	170-181
8280139-7	1993	These three mutations result in changes of glycine to arginine and of tyrosine to aspartic acid at amino acid positions 71 and 486 of the UGT1A protein, and of leucine to proline and of tyrosine to aspartic acid at amino acid positions 132 and 487 of the UGT1D protein, respectively.	Arginine	54-62	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	255-260
8223474-2	1993	The DNA-binding domain of HAP2 is shown to be a 21 residue region containing three critical histidines and three critical arginines.	Arginine	122-131	transcription activator HAP2	Saccharomyces cerevisiae S288C	26-30
8307321-3	1993	Three mutations in sqt-1 and one in rol-6 that cause dominant right-handed helical twisting (RRol) of animals are arginine to cysteine replacements.	Arginine	114-122	Cuticle collagen sqt-1	Caenorhabditis elegans	19-24
8136028-7	1993	It is concluded that C1 assembly involves interactions between acidic amino acids of C1r and lysine (hydroxylysine) and arginine residues located within the collagen-like region of C1q.	Arginine	120-128	complement C1q A chain	Homo sapiens	181-184
8246952-7	1993	In contrast to the results obtained with p120GAP, the Pro-34--&gt;Arg p21 species is effectively coupled to the raf-1 product, as judged from electrophoretic mobility shifts of the Raf-1 phosphoprotein.	Arginine	66-69	H3 histone pseudogene 16	Homo sapiens	70-73
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Arginine	27-30	C-C motif chemokine ligand 14	Homo sapiens	102-106
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Arginine	35-38	C-C motif chemokine ligand 14	Homo sapiens	102-106
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Arginine	35-38	C-C motif chemokine ligand 14	Homo sapiens	102-106
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Arginine	35-38	C-C motif chemokine ligand 14	Homo sapiens	102-106
8227358-5	1993	A repeating octapeptide of Arg-Ser-Arg-Ser-Arg(Lys)-Glu(Asp)-Arg-Lys(Arg) was present in RS region of HCC1.	Arginine	35-38	C-C motif chemokine ligand 14	Homo sapiens	102-106
7508296-1	1993	Epitope-tagged Xenopus nucleolin was expressed in Escherichia coli cells and in Xenopus oocytes either as a full-length wild-type protein or as a truncation that lacked the distinctive carboxy glycine/arginine-rich (GAR) domain.	Arginine	201-209	nucleolin S homeolog	Xenopus laevis	23-32
7804366-4	1993	The data showed that a single amino acid substitution of tyrosine by phenylalanine and a number of amino acids including serine, asparagine, histidine and arginine at position 97 in the VH CDR3 region all resulted in approximate 18-fold lower binding affinity, whereas the substitution of tyrosine by phenylalanine at position 96 in the VH CDR3 region did not affect the binding affinity of the cB72.3m4 antibody.	Arginine	155-163	cerebellar degeneration-related 3	Mus musculus	340-344
8404868-6	1993	We show that the major ubiquitination site in Mos is a Lys34 residue and that replacement of this residue with a non-ubiquitinatable Arg residue markedly enhances the stability of Mos on egg activation.	Arginine	133-136	MOS proto-oncogene, serine/threonine kinase L homeolog	Xenopus laevis	180-183
8376387-11	1993	Recombinant SPC3 also cleaved human proalbumin following the Arg-Gly-Val-Phe-Arg-Arg prosequence.	Arginine	61-64	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8376387-11	1993	Recombinant SPC3 also cleaved human proalbumin following the Arg-Gly-Val-Phe-Arg-Arg prosequence.	Arginine	77-80	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8376387-13	1993	Recombinant SPC3 was also able to cleave after a single arginine residue in chicken proalbumin following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence.	Arginine	56-64	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8376387-13	1993	Recombinant SPC3 was also able to cleave after a single arginine residue in chicken proalbumin following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence.	Arginine	109-112	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8376387-13	1993	Recombinant SPC3 was also able to cleave after a single arginine residue in chicken proalbumin following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8376387-13	1993	Recombinant SPC3 was also able to cleave after a single arginine residue in chicken proalbumin following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence.	Arginine	125-128	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8105132-2	1993	On the other hand, it has been shown that nitric oxide (NO) is synthesized from L-arginine and released by the endothelium of blood vessels and accounts for the activity of endothelium-derived relaxing factor (EDRF).	Arginine	80-90	alpha hemoglobin stabilizing protein	Homo sapiens	173-208
8105132-2	1993	On the other hand, it has been shown that nitric oxide (NO) is synthesized from L-arginine and released by the endothelium of blood vessels and accounts for the activity of endothelium-derived relaxing factor (EDRF).	Arginine	80-90	alpha hemoglobin stabilizing protein	Homo sapiens	210-214
7688901-12	1993	TNF alpha inhibits SNS at the level of the neuron by a mechanism involving the L-arginine-nitric oxide pathway.	Arginine	79-89	tumor necrosis factor	Bos taurus	0-9
8367462-3	1993	The Arg-specific pocket of HLA-B*2705 differs markedly from those of HLA-A*0201 and HLA-A*6801, as a result of numerous differences in the side chains that form the pocket"s surface.	Arginine	4-7	major histocompatibility complex, class I, B	Homo sapiens	27-32
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Arginine	159-162	phosphoenolpyruvate carboxylase	Nicotiana tabacum	80-84
8344429-4	1993	These reciprocal phosphorylation experiments (i) indicate that Ser11 of tobacco PEPC is the likely target residue, situated in the plant-invariant Glu/Asp-Lys/Arg-X-X-Ser phosphorylation motif near the N-terminus, and (ii) lend support to the recent hypothesis that C3-leaf PEPC is subject to regulatory phosphorylation in vivo.	Arginine	159-162	phosphoenolpyruvate carboxylase	Nicotiana tabacum	274-278
8331659-9	1993	Docking of the pentasaccharide unit which represents the minimum fragment of heparin able to bind to ATIII indicates a possible role for arginine 14 in the interaction of heparin and the protein.	Arginine	137-145	serpin family C member 1	Homo sapiens	101-106
21573320-2	1993	Such sequencing artefacts were also observed with a p53 cDNA isolated from mouse T3T3 cells, encoding a mutant p53 with an Arg-Cys exchange at position 270, and could be resolved by sequencing of the opposite DNA strands.	Arginine	123-126	transformation related protein 53, pseudogene	Mus musculus	52-55
21573320-2	1993	Such sequencing artefacts were also observed with a p53 cDNA isolated from mouse T3T3 cells, encoding a mutant p53 with an Arg-Cys exchange at position 270, and could be resolved by sequencing of the opposite DNA strands.	Arginine	123-126	transformation related protein 53, pseudogene	Mus musculus	111-114
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	71-74	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	0-3
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	71-74	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	11-14
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	0-3
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	11-14
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	0-3
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	11-14
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	0-3
8413849-4	1993	PC1 and/or PC2 and/or furin may cleave at the dibasic amino acid pairs Arg-Arg at the C-terminal part of proCCK, and Arg-X-X-Arg at the N-terminal of the CCK-58 sequence in proCCK.	Arginine	75-78	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	11-14
8332490-0	1993	Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.	Arginine	74-82	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	21-26
8232264-6	1993	Modification in the presence of fatty acid revealed the protection of one of the two arginines of L-FABP.	Arginine	85-94	fatty acid binding protein 1	Bos taurus	98-104
8392392-4	1993	Proteinases recognize a specific peptide, termed the reactive site, near the carboxyl-terminus of serpins (for antithrombin and protein C inhibitor this is Arg-Ser and for heparin cofactor II this is Leu-Ser).	Arginine	156-159	serpin family C member 1	Homo sapiens	111-123
8500273-6	1993	In the same animals, anti-LFA-1 partially (35-50%) inhibited PMNL accumulation in acute dermal inflammation induced by zymosan-activated serum (ZAS, C5ades Arg), IL-1 or endotoxin (P &lt; 0.01) and suppressed T lymphocyte migration to dermal DTH, IFN-gamma, LPS, and poly-I:C-induced inflammation by 60-80%.	Arginine	156-159	integrin subunit alpha L	Rattus norvegicus	26-31
8508705-4	1993	The response of microvillous enzymes (lactase, sucrase, maltase, and aminopeptidase) to spermine was dose-dependent and -specific since oral administration of arginine (5 mumol) or ornithine (5 mumol) was without effect.	Arginine	159-167	lactase	Rattus norvegicus	38-45
8497072-5	1993	The change of an arginine to an isoleucine codon in V3 (I-308), in the presence of the Q-267 mutation, restores virus infectivity to near wild-type levels by increasing the amount of gp120 associated with virions as compared with the Q-267 mutant but does not compensate for the Q-267-induced processing defect.	Arginine	17-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	183-188
8337118-10	1993	HPA-4 (Pen, Yuk) as HPA1 is on GPIIIa but in a different location (Arg&lt;==&gt;Gln 143).	Arginine	67-70	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	7-10
8496156-1	1993	Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras.	Arginine	18-21	HRas proto-oncogene, GTPase	Homo sapiens	68-74
8486681-1	1993	The tyrosine at position 13 of epidermal growth factor (EGF) has been implicated as playing a role in receptor binding due to its close proximity to the critical arginine 41 residue as well as its high degree of conservation in EGF and EGF-like proteins that can bind to the EGF receptor.	Arginine	162-170	epidermal growth factor	Homo sapiens	31-54
8486681-1	1993	The tyrosine at position 13 of epidermal growth factor (EGF) has been implicated as playing a role in receptor binding due to its close proximity to the critical arginine 41 residue as well as its high degree of conservation in EGF and EGF-like proteins that can bind to the EGF receptor.	Arginine	162-170	epidermal growth factor	Homo sapiens	56-59
8486681-7	1993	Analysis of three hEGF mutants, Tyr13--&gt;Leu, Tyr13--&gt;Arg, and Tyr13--&gt;Gly, by circular dichroism showed that the major structural features of hEGF were not significantly altered.	Arginine	59-62	epidermal growth factor	Homo sapiens	18-22
8476047-5	1993	This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P &lt; 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media.	Arginine	133-141	interleukin 1 alpha	Homo sapiens	53-57
8476047-8	1993	When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P &lt; 0.05).	Arginine	133-141	interleukin 1 alpha	Homo sapiens	161-165
8499568-0	1993	A Gla domain mutation (Arg 15--&gt;Trp) in the protein C (PROC) gene causing type 2 protein C deficiency and recurrent venous thrombosis.	Arginine	23-26	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	47-56
8455631-0	1993	Genetic evidence for a role for MCM1 in the regulation of arginine metabolism in Saccharomyces cerevisiae.	Arginine	58-66	transcription factor MCM1	Saccharomyces cerevisiae S288C	32-36
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	47-55	transcription factor MCM1	Saccharomyces cerevisiae S288C	21-25
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	47-55	transcription factor MCM1	Saccharomyces cerevisiae S288C	102-106
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	159-167	transcription factor MCM1	Saccharomyces cerevisiae S288C	21-25
8455631-3	1993	The participation of MCM1 in the regulation of arginine metabolism is confirmed by the behavior of an mcm1-gcn4 mutant, which is affected in the repression of arginine anabolic genes.	Arginine	159-167	transcription factor MCM1	Saccharomyces cerevisiae S288C	102-106
8486606-6	1993	The evidence obtained suggests that (i) arginine-rich sperm proteins function as potent activators for CK-II in unfertilized eggs and (ii) specific phosphorylation of p98 by the activated kinase may play an important role in the transcriptional regulation in the eggs accompanying fertilization.	Arginine	40-48	casein kinase 2 alpha 1	Homo sapiens	103-108
7681676-1	1993	GluR6, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel-forming segment TM2.	Arginine	109-117	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	0-5
8432994-5	1993	Sm/DNA-specific hybridomas, but not Sm-only-specific hybridomas, have a higher than expected content of arginine residues in CDR3 of the H chain, similar to MRL/lpr hybridomas selected on the basis of DNA binding.	Arginine	104-112	cerebellar degeneration-related 3	Mus musculus	125-129
8426739-2	1993	We analysed the function of one of these mutations, an arg-to-trp substitution at amino acid 245 in the murine p53 gene.	Arginine	55-58	transformation related protein 53, pseudogene	Mus musculus	111-114
1360148-2	1992	Fusion activity requires proteolytic cleavage of the gp160 protein into gp120 and gp41 at a site containing several arginine and lysine residues.	Arginine	116-124	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	72-77
1280597-2	1992	In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta.	Arginine	49-59	interferon gamma	Rattus norvegicus	137-153
1331071-2	1992	Recent structure/function studies on human relaxin II have led to the conclusion that the arginines B13 and/or B17 are important for biological activity.	Arginine	90-99	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	100-103
1331071-6	1992	The inactivation is strictly due to side chain functions, in particular the replacement of either or both arginines in the positions B13 or B17.	Arginine	106-115	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	133-136
1331071-7	1992	Binding is mediated by a two-prong electrostatic and hydrogen-binding interaction via arginines B13 and B17.	Arginine	86-95	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	96-99
1385408-5	1992	In the disintegrin region, the Arg-Gly-Asp sequence is replaced by Glu-Cys-Asp, as found in non-Arg-Gly-Asp disintegrin regions of HR1B and a guinea pig sperm fusion protein PH-30 beta.	Arginine	31-34	disintegrin and metalloproteinase domain-containing protein 2	Cavia porcellus	174-184
1400233-1	1992	Arginase (CAR1) gene expression in Saccharomyces cerevisiae is induced by arginine.	Arginine	74-82	arginase	Saccharomyces cerevisiae S288C	10-14
1466657-2	1992	This creates a substitution of glutamine for arginine in the codon for amino acid 3500 and results in reduced affinity of low density lipoprotein (LDL) to the LDL receptor.	Arginine	45-53	low density lipoprotein receptor	Homo sapiens	159-171
1511989-0	1992	Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis.	Arginine	36-39	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	51-60
1511989-1	1992	Non-identical missense mutations were identified at Arg 178 in the protein C genes of two patients with heterozygous type 1 protein C deficiency and recurrent venous thrombosis.	Arginine	52-55	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	67-76
1619654-6	1992	In intramolecular interactions, the aspartate favours a "side on" geometry, forming hydrogen bonds with N epsilon and N eta 2; in the intermolecular case, however, "end on" contacts involving N eta 1 and N eta 2 of the arginine are preferred.	Arginine	219-227	secreted phosphoprotein 1	Homo sapiens	194-211
1637938-8	1992	On the basis of putative cleavage sites on the SP-10 sequence, endoproteases that act at five different peptide bonds are predicted to cleave SP-10: these hydrolyze following arginine (a trypsin-like protease, possibly acrosin), and following serine, proline, glycine, and glutamic acid (previously undescribed intra-acrosomal protease specificities).	Arginine	175-183	acrosin	Homo sapiens	219-226
1610817-3	1992	The guanidinium NH2 nitrogen of Arg 44 forms one hydrogen bond to the imide nitrogen and a second to the carbonyl oxygen of Pro 66 in wild-type DHFR.	Arginine	32-35	Dihydrofolate reductase	Escherichia coli	144-148
1534057-3	1992	The release of amylin from the perfused pancreases in response to glucose and arginine paralleled that of insulin in all three groups.	Arginine	78-86	islet amyloid polypeptide	Rattus norvegicus	15-21
1534057-6	1992	The increased amylin-insulin molar ratios of both n2STZ and n5STZ pancreases also occurred during infusions of 33.3 mM glucose and 10 mM arginine.	Arginine	137-145	islet amyloid polypeptide	Rattus norvegicus	14-20
1283100-6	1992	IGFBP-3 and -4 are glycosylated, whereas IGFBP-1 and -2 contain an Arg-Gly-Asp sequence near the carboxyl terminus.	Arginine	67-70	insulin like growth factor binding protein 1	Homo sapiens	41-55
1601131-2	1992	Recombinant vimentin expressed in E. coli JM 101 cells is cleaved after cell lysis between arginines 11 and 12.	Arginine	91-100	vimentin	Homo sapiens	12-20
1315505-4	1992	Similarly, IL-1-induced CSF-1 production was inhibited by cholera toxin and this inhibition was reversed by an arginine analog, p-methoxy-benzylaminodecamethylene guanidine sulfate.	Arginine	111-119	interleukin 1 alpha	Homo sapiens	11-15
1315505-4	1992	Similarly, IL-1-induced CSF-1 production was inhibited by cholera toxin and this inhibition was reversed by an arginine analog, p-methoxy-benzylaminodecamethylene guanidine sulfate.	Arginine	111-119	colony stimulating factor 1	Homo sapiens	24-29
1321724-1	1992	Cardiac troponin I contains two adjacent serines in sequence after three arginine residues thus making up a minimally duplicated recognition motif for cAMP-dependent protein kinase.	Arginine	73-81	troponin I3, cardiac type	Rattus norvegicus	0-18
1577739-4	1992	S6 kinase II phosphorylated at least four sites (serines 1-3 and 5) in the sequence Arg-Arg-Leu-Ser(1)-Ser(2)-Leu-Arg-Ala-Ser(3)-Thr-Ser(4)-Lys-Ser(5)-, which correspond to the residues known to be phosphorylated in the carboxyl-terminal region of mammalian S6.	Arginine	84-87	ribosomal protein S6 kinase A6 S homeolog	Xenopus laevis	0-12
1577739-4	1992	S6 kinase II phosphorylated at least four sites (serines 1-3 and 5) in the sequence Arg-Arg-Leu-Ser(1)-Ser(2)-Leu-Arg-Ala-Ser(3)-Thr-Ser(4)-Lys-Ser(5)-, which correspond to the residues known to be phosphorylated in the carboxyl-terminal region of mammalian S6.	Arginine	88-91	ribosomal protein S6 kinase A6 S homeolog	Xenopus laevis	0-12
1577739-4	1992	S6 kinase II phosphorylated at least four sites (serines 1-3 and 5) in the sequence Arg-Arg-Leu-Ser(1)-Ser(2)-Leu-Arg-Ala-Ser(3)-Thr-Ser(4)-Lys-Ser(5)-, which correspond to the residues known to be phosphorylated in the carboxyl-terminal region of mammalian S6.	Arginine	88-91	ribosomal protein S6 kinase A6 S homeolog	Xenopus laevis	0-12
1619908-4	1992	When 10 microM L-arginine RPMI-1640 was used to simulate the high arginase activity low L-arginine levels of the hepatic microenvironment, regenerating liver KC production of IL-1 was further increased (p less than 0.05).	Arginine	15-25	interleukin 1 alpha	Homo sapiens	175-179
1619908-4	1992	When 10 microM L-arginine RPMI-1640 was used to simulate the high arginase activity low L-arginine levels of the hepatic microenvironment, regenerating liver KC production of IL-1 was further increased (p less than 0.05).	Arginine	88-98	interleukin 1 alpha	Homo sapiens	175-179
1353910-4	1992	In this report we show that a G-to-A transition in the first position of codon 717 of the EF-2 gene results in substitution of arginine for glycine and prevents addition of the side chain of diphthamide to histidine 715 of EF-2.	Arginine	127-135	eukaryotic translation elongation factor 2	Homo sapiens	90-94
1353910-4	1992	In this report we show that a G-to-A transition in the first position of codon 717 of the EF-2 gene results in substitution of arginine for glycine and prevents addition of the side chain of diphthamide to histidine 715 of EF-2.	Arginine	127-135	eukaryotic translation elongation factor 2	Homo sapiens	223-227
1374249-6	1992	The effects of chemical and enzymatic treatments on rat CYP1A1 showed that the epitope contains a trypsin-sensitive site that includes arginine, but lacks lysine.	Arginine	135-143	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	56-62
1374249-10	1992	It is concluded that the epitope for this antibody is Phe-Arg-His-Ser-Ser-Phe, which lies at positions 380-385 in rat CYP1A1.	Arginine	58-61	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	118-124
1550123-7	1992	Proband 1 was homoallelic for a T-to-C transition in nucleotide (nt) 349, which predicted a cysteine-to-arginine substitution in the ASB polypeptide at residue 117 (C117R).	Arginine	104-112	arylsulfatase B	Homo sapiens	133-136
1566916-9	1992	The data support the hypothesis that L-arginine acts as a substrate for synthesis of "classical" EDRF in brain microvessels in vivo.	Arginine	37-47	alpha hemoglobin stabilizing protein	Homo sapiens	97-101
1566916-11	1992	Increasing the substrate by exposing the vessels to L-arginine for 10 min permitted ACh to release sufficient EDRF to elicit dilatation.	Arginine	52-62	alpha hemoglobin stabilizing protein	Homo sapiens	110-114
1544144-10	1992	Rats fed 1% orotic acid or arginine-deficient diets also showed more and larger foci positive for gamma-glutamyl transpeptidase and more liver tumors after administration of carcinogens and partial hepatectomy.	Arginine	27-35	gamma-glutamyltransferase 1	Rattus norvegicus	98-127
1546902-0	1992	Enhancement of interleukin-2 immunotherapy with L-arginine.	Arginine	48-58	interleukin 2	Mus musculus	15-28
1546902-3	1992	This experiment also assessed supplemental dietary L-arginine as a means to potentiate the host antitumor response to interleukin-2 (IL-2) in a murine neuroblastoma (NRB) model.	Arginine	51-61	interleukin 2	Mus musculus	118-131
1546902-3	1992	This experiment also assessed supplemental dietary L-arginine as a means to potentiate the host antitumor response to interleukin-2 (IL-2) in a murine neuroblastoma (NRB) model.	Arginine	51-61	interleukin 2	Mus musculus	133-137
1546902-8	1992	Interleukin-2 therapy in mice receiving dietary arginine compared with those receiving glycine resulted in significantly augmented natural killer cell cytotoxicity (day 4) and generation of specific tumoricidal mechanisms (day 10).	Arginine	48-56	interleukin 2	Mus musculus	0-13
1546902-9	1992	The addition of dietary arginine to low-dose IL-2 therapy significantly diminished C1300 NRB engraftment (p less than 0.05) and growth (p less than 0.001) and prolonged the duration of host survival (p less than 0.05) compared with the glycine treatment group.	Arginine	24-32	interleukin 2	Mus musculus	45-49
1546902-11	1992	Thus, supplemental dietary L-arginine enhances lymphocyte cytotoxic mechanisms and potentiates IL-2 immunotherapy.	Arginine	27-37	interleukin 2	Mus musculus	95-99
1309740-3	1992	Mutations that substitute cysteine for the corresponding arginine residues of alpha s and alpha i2 constitutively activate their respective effector pathways, creating the gsp and gip2 oncogenes.	Arginine	57-65	GSM1	Homo sapiens	172-175
1732513-4	1992	Of the charged amino acids in the C"" and D strands of the amino-terminal domain of CD4, alteration of only two, lysine 46 and arginine 59, dramatically disrupted ability to bind gp120.	Arginine	127-135	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	179-184
1623301-1	1992	Pseudopeptide analogues of the C-terminal hexapeptide of neurotensin (H-Arg-Arg-Pro-Tyr-Ile-Leu-OH) were obtained by replacing each peptide bond by the reduced peptide bond CH2NH.	Arginine	72-75	neurotensin/neuromedin N	Cavia porcellus	57-68
1370358-3	1992	For these RFs, His-435 is a critical residue for binding and replacing it with arginine, the residue present in IgG3, destroys or reduces RF binding.	Arginine	79-87	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	112-116
1807008-5	1991	When arginine was infused, GLP-1 (7-20), (7-36), (7-37), and glucagon enhanced insulin release.	Arginine	5-13	glucagon	Canis lupus familiaris	27-32
1961019-8	1991	Endoglin contains an arginine-glycine-aspartic acid sequence, a feature generally associated with extracellular matrix proteins which interact with integrins.	Arginine	21-29	endoglin	Homo sapiens	0-8
1723139-1	1991	Site-directed mutagenesis of the arginine-rich region within the putative active site of the rat testicular P45017 alpha (17 alpha-hydroxylase cytochrome P-450, the product of P450XVII gene) was performed to identify specific amino acids that contribute to either the hydroxylase or lyase activities catalyzed by this enzyme.	Arginine	33-41	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	108-120
1896454-2	1991	VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.	Arginine	183-186	fibronectin 1	Mus musculus	153-155
1896461-2	1991	Expression of an AMY1 cDNA in yeast thus leads to four secreted forms with distinct pI values between 4.7 and 5.1 and essentially identical Mr. AMY1-1 and AMY1-2 lacking the C-terminal Arg-Ser are generated by carboxypeptidase in vitro from AMY1-3 and AMY1-4, respectively.	Arginine	185-188	drug-responsive transcription factor PDR1	Saccharomyces cerevisiae S288C	17-21
1909576-3	1991	Various substitutions of Arg-41 resulted in substantial reduction in receptor affinity of EGF whereas change of Tyr-13 did not affect binding to the receptor.	Arginine	25-28	epidermal growth factor	Homo sapiens	90-93
1868238-11	1991	These data demonstrate that EDRF/NO formation from L-arginine by human EC plays an important role as an aspirin-insensitive fluid-phase inhibitor of human platelet reactivity.	Arginine	51-61	alpha hemoglobin stabilizing protein	Homo sapiens	28-32
1860552-0	1991	Release of amylin from perfused rat pancreas in response to glucose, arginine, beta-hydroxybutyrate, and gliclazide.	Arginine	69-77	islet amyloid polypeptide	Rattus norvegicus	11-17
1860552-2	1991	The isolated perfused normal rat pancreas was used to evaluate the effects of glucose and insulin secretagogues, such as arginine, beta-hydroxybutyrate, and gliclazide, on amylin secretion.	Arginine	121-129	islet amyloid polypeptide	Rattus norvegicus	172-178
1856214-7	1991	A CK II-specific peptide (Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu) and the C-22 peptide inhibited the phosphorylation of the P proteins by the endogenous kinase, providing further evidence for its CK II-like properties and for localization of the CK II phosphorylation site to the COOH termini of the P proteins.	Arginine	26-29	casein kinase 2 alpha 1	Homo sapiens	2-7
1856214-7	1991	A CK II-specific peptide (Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu) and the C-22 peptide inhibited the phosphorylation of the P proteins by the endogenous kinase, providing further evidence for its CK II-like properties and for localization of the CK II phosphorylation site to the COOH termini of the P proteins.	Arginine	30-33	casein kinase 2 alpha 1	Homo sapiens	2-7
1856214-7	1991	A CK II-specific peptide (Arg-Arg-Arg-Glu-Glu-Glu-Thr-Glu-Glu-Glu) and the C-22 peptide inhibited the phosphorylation of the P proteins by the endogenous kinase, providing further evidence for its CK II-like properties and for localization of the CK II phosphorylation site to the COOH termini of the P proteins.	Arginine	30-33	casein kinase 2 alpha 1	Homo sapiens	2-7
1772311-5	1991	Human acrosin showed a broad substrate specificity for arginine and lysine derivatives and it seemed to have a somewhat different specificity from trypsin.	Arginine	55-63	acrosin	Homo sapiens	6-13
1742357-5	1991	These results show that the structures of the two domains containing diphtamide 715 and the phosphorylatable threonines (between Ala 51 and Arg 60) are interdependent; modifications of these residues induce different conformational changes of EF-2 which alter the interactions of the factor with guanylic nucleotides as well with ribosomes.	Arginine	140-143	eukaryotic translation elongation factor 2	Homo sapiens	243-247
2059207-1	1991	In enterocytes isolated from pig jejunum, L-arginine is metabolized to L-citrulline either directly or indirectly through the sequence of reactions catalysed by arginase and ornithine transcarbamylase.	Arginine	42-52	ornithine transcarbamylase	Sus scrofa	174-200
1710829-5	1991	The properties of heteromeric wild-type and mutant GluRs revealed that the dominance of GluR-B is due to the arginine residue in the TM2 region.	Arginine	109-117	glutamyl-tRNA synthetase 2, mitochondrial	Homo sapiens	51-56
1857778-3	1991	The first phase of L-arginine-stimulated insulin release was also potentiated by pancreastatin (6.9 +/- 0.5 ng/5 min in controls, 8.4 +/- 0.6 ng/5 min in pancreastatin group), but not by CGA.	Arginine	19-29	insulin	Bos taurus	41-48
1681125-2	1991	A mitochondrial DNA (mtDNA) replacement mutation in LHON patient, G to A transition at nucleotide position (nt) 11778 converting the 340th arginine to histidine in the NADH dehydrogenase subunit 4, was detected as SfaNI site polymorphism (Wallace et al., Science, 242: 1427-1430, 1988).	Arginine	139-147	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	168-196
1709810-5	1991	FAB analysis revealed that the N terminus of the mature protein is arginine rather than threonine, with the threonine occupying the second position.	Arginine	67-75	FA complementation group B	Homo sapiens	0-3
1850997-2	1991	Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin.	Arginine	89-92	vimentin	Homo sapiens	238-246
1850997-2	1991	Sequential analysis of the purified phosphopeptides demonstrated that the sites are -Thr-Arg-Thr-Tyr-Ser(PO4)38-Leu-Gly-Ser-Ala- and -Val-Arg-Leu-Leu-Gln-Asp-Ser(PO4)82-Val-Asp-, which are located within the amino-terminal head domain of vimentin.	Arginine	138-141	vimentin	Homo sapiens	238-246
2005387-3	1991	Cytotoxicity of M phi activated by IFN-gamma plus LPS was detected in the presence of about 0.1 mM or more of L-arginine.	Arginine	110-120	interferon regulatory factor 6	Homo sapiens	50-53
2005387-10	1991	In addition, we found that M phi which had lost tumoricidal activity during culture in L-arginine deficient medium could be reactivated by LPS to attack tumor target cells.	Arginine	87-97	interferon regulatory factor 6	Homo sapiens	139-142
1672055-7	1991	L-Arginine dose dependently increased the relaxing activity of SRF, whereas NG-monomethyl-L-arginine (L-NMMA) decreased it, and this decrease was reversed by L-arginine.	Arginine	0-10	serum response factor	Rattus norvegicus	63-66
1672055-9	1991	These data suggest that SRF may represent a relaxing factor that is synthesized de novo from L-arginine.	Arginine	93-103	serum response factor	Rattus norvegicus	24-27
1986798-11	1991	It is unlikely that peptide F could be a substrate for kallikrein in vivo; however, tissue kallikrein could aid in processing proenkephalin precursors such as BAM-22P by cleaving Arg-Arg peptide bonds.	Arginine	179-182	kallikrein 1	Bos taurus	84-101
1986798-11	1991	It is unlikely that peptide F could be a substrate for kallikrein in vivo; however, tissue kallikrein could aid in processing proenkephalin precursors such as BAM-22P by cleaving Arg-Arg peptide bonds.	Arginine	183-186	kallikrein 1	Bos taurus	84-101
1953609-3	1991	Since endothelium-derived relaxing factor is now known to be nitric oxide derived from the metabolism of L-arginine, we hypothesized that the abnormal vascular response in hypercholesterolemia could be corrected by supplying the precursor to EDRF, L-arginine.	Arginine	105-115	alpha hemoglobin stabilizing protein	Homo sapiens	242-246
1953609-3	1991	Since endothelium-derived relaxing factor is now known to be nitric oxide derived from the metabolism of L-arginine, we hypothesized that the abnormal vascular response in hypercholesterolemia could be corrected by supplying the precursor to EDRF, L-arginine.	Arginine	248-258	alpha hemoglobin stabilizing protein	Homo sapiens	242-246
1650724-2	1991	A mutant of the iso-1-cytochrome c gene from Saccharomyces cerevisiae has been constructed which contains an Arg codon, replacing the normal trimethylated Lys at position 77.	Arginine	109-112	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	16-21
2123870-4	1990	We have previously demonstrated that mutation of arginine 304 of t-PA to a glutamic acid residue drastically reduces the rate of interaction between the enzyme and its suicide substrate, PAI-1, without affecting the reactivity of the enzyme toward its normal substrate, plasminogen (Madison, E. L., Goldsmith, E. J., Gerard, R.D., Gething, M.J., and Sambrook, J.F.	Arginine	49-57	serpin family E member 1	Homo sapiens	187-192
2229048-3	1990	Two bactenecins, with an approximate molecular weight of 7000 and 5000, called Bac7 and Bac5, are characterized by a high content of proline (greater than 45%) and arginine (greater than 23%) residues.	Arginine	164-172	cathelicidin-3	Bos taurus	79-83
2229048-3	1990	Two bactenecins, with an approximate molecular weight of 7000 and 5000, called Bac7 and Bac5, are characterized by a high content of proline (greater than 45%) and arginine (greater than 23%) residues.	Arginine	164-172	cathelicidin-2	Bos taurus	88-92
2229048-5	1990	Bac7 comprises 59 residues and includes three tandem repeats of a tetradecamer characterized by several Pro-Arg-Pro triplets spaced by single hydrophobic amino acids.	Arginine	108-111	cathelicidin-3	Bos taurus	0-4
2229048-7	1990	Bac5 comprises 42 amino acid residues with a repeated motif of Arg-Pro-Pro triplets also alternating with single apolar residues.	Arginine	63-66	cathelicidin-2	Bos taurus	0-4
2229057-0	1990	Important role of arginine 129 in heparin-binding site of antithrombin III.	Arginine	18-26	serpin family C member 1	Homo sapiens	58-74
2229057-4	1990	This amino acid is part of the ATIII region comprising residues 114-154, which contains the highest proportion of basic residues (Arg or Lys), and is known from chemical modification studies to be involved in heparin binding.	Arginine	130-133	serpin family C member 1	Homo sapiens	31-36
2229057-7	1990	Taken together, these results demonstrate an important role for Arg-129 in the binding and interaction of ATIII with heparin of high affinity.	Arginine	64-67	serpin family C member 1	Homo sapiens	106-111
2229057-8	1990	We propose that a cooperation between Lys-125, Arg-129, Lys-136, and Arg-47 exposed at the surface of the inhibitor allows the binding of the essential pentasaccharide domain of heparin which is specific for the ATIII interaction.	Arginine	47-50	serpin family C member 1	Homo sapiens	212-217
2229057-8	1990	We propose that a cooperation between Lys-125, Arg-129, Lys-136, and Arg-47 exposed at the surface of the inhibitor allows the binding of the essential pentasaccharide domain of heparin which is specific for the ATIII interaction.	Arginine	69-72	serpin family C member 1	Homo sapiens	212-217
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Arginine	114-117	pregnancy specific beta-1-glycoprotein 9	Homo sapiens	0-4
2271938-1	1990	Polyclonal rabbit antisera specific to argininosuccinate synthetase (ASS), argininosuccinate lyase and arginase revealed that these enzymes of L-arginine metabolism are generally localized in different cells of the rat brain.	Arginine	143-153	argininosuccinate lyase	Rattus norvegicus	75-98
2144548-3	1990	Addition of NG monomethyl-L-arginine (NMA), a competitive inhibitor of oxidative L-arginine metabolism, to rat splenocyte (SPL) MLC results in allospecific lymphocyte proliferation and CTL induction.	Arginine	26-36	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	128-131
2394749-10	1990	The predicted reactive site (P1-P1") of this J6 protein is Arg-Ser, which is the same as that of antithrombin III.	Arginine	59-62	serpin family C member 1	Homo sapiens	97-113
2124504-2	1990	Studies have suggested that in Lactobacillus casei dihydrofolate reductase Arg-43, the homologous residue at this position, plays an important role in the binding of NADPH and in the differentiation of Km values for NADPH and NADH.	Arginine	75-78	dihydrofolate reductase	Homo sapiens	51-74
2232482-6	1990	The pH optimum for cathepsin B (substrate: Z-Arg-Arg-HNMec) and L (substrate: Z-Phe-Arg-HNMec in the presence of Z-Phe-Phe-CHN2) was approximately pH 6.0 for both glomeruli and renal cortex; while that for cathepsin H (substrate: Arg-HNMec) was approximately 6.5.	Arginine	45-48	cathepsin B	Rattus norvegicus	19-30
2395872-4	1990	Sequence analysis of the isolated secretin precursor revealed a 71-amino acid residue polypeptide that contained the sequence of secretin N terminally, followed by a Gly-Lys-Arg sequence and a C-terminal extension of 41-amino acid residues.	Arginine	174-177	secretin	Sus scrofa	34-42
2198282-10	1990	We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40.	Arginine	86-89	interleukin 1 alpha	Homo sapiens	25-36
2289461-3	1990	The variant is likely to be a mutant of the most prominent forms of SAA (SAA1 and SAA2, or SAA1 and SAA1 des Arg).	Arginine	109-112	serum amyloid A2	Homo sapiens	68-71
2318314-0	1990	Identification of the Arg-Gly-Asp sequence in laminin A chain as a latent cell-binding site being exposed in fragment P1.	Arginine	22-25	laminin subunit alpha 1	Homo sapiens	46-61
2140277-7	1990	We proposed that three basic amino acids corresponding to arginine 73 and lysines 82 and 96 in Escherichia coli thioredoxin play an important role in the anchorage of the thioredoxin to the negatively charged surface of the CF1 and are involved in the dual effect of KCl.	Arginine	58-66	thioredoxin	Homo sapiens	112-123
2140277-7	1990	We proposed that three basic amino acids corresponding to arginine 73 and lysines 82 and 96 in Escherichia coli thioredoxin play an important role in the anchorage of the thioredoxin to the negatively charged surface of the CF1 and are involved in the dual effect of KCl.	Arginine	58-66	thioredoxin	Homo sapiens	171-182
2126195-7	1990	Using modified peptides we have shown that lysine or arginine is crucial for the interaction with HLA B27.	Arginine	53-61	major histocompatibility complex, class I, B	Homo sapiens	98-105
2181240-4	1990	A mutation leading to increased permeability of the outer membrane to hydrophobic agents, previously localized to the traT gene, was shown to change a glycine residue to arginine within one of these hydrophobic regions.	Arginine	170-178	TraT	Salmonella enterica subsp. enterica serovar Typhimurium	118-122
33942982-13	2021	In conclusion, we revealed circ_0023404 contributed to HK-2 cells injury stimulated by H/R via sponging miR-136 and activating IL-6R.	Arginine	89-90	microRNA 136	Homo sapiens	104-111
33940493-2	2021	The objective of this study was to investigate daily- and age-dependent changes in the regulation of Arg-Phe amide-related peptide-3 (RFRP-3), a hypothalamic peptide involved in reproduction, and correlate those changes to the luteinizing hormone (LH) secretion in female C57BL/6 J mice of different age groups (4-, 13-, and 19- months old).	Arginine	101-104	neuropeptide VF precursor	Mus musculus	134-138
33811140-3	2021	This releases U1-70K from subnuclear granules facilitating interaction with U1 snRNP and the serine-arginine (SR) protein SRSF1, critical steps in establishing the 5" splice site.	Arginine	100-108	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	14-20
33794079-14	2021	CONCLUSIONS: It was concluded that in Hist139Arg of EPHX gene, fast genotype (Arg-Arg) was associated with impaired ventilatory functions.	Arginine	45-48	epoxide hydrolase 1	Homo sapiens	52-56
33794079-14	2021	CONCLUSIONS: It was concluded that in Hist139Arg of EPHX gene, fast genotype (Arg-Arg) was associated with impaired ventilatory functions.	Arginine	78-81	epoxide hydrolase 1	Homo sapiens	52-56
33804322-11	2021	Molecular docking speculated that C3G could form hydrogen bonds with alpha-glucosidase by binding to the active sit (Leu 313, Ser 157, Tyr 158, Phe 314, Arg 315, and two Asp 307).	Arginine	153-156	sucrase-isomaltase	Homo sapiens	69-86
22814518-5	2012	Deimination is the conversion of certain arginine residues in proteins to citrullines by the enzyme peptidylarginine deiminase 4.	Arginine	41-49	peptidyl arginine deiminase 4	Homo sapiens	100-128
19584108-6	2009	Piwi proteins were found in complex with PRMT5/WDR77, an enzyme that dimethylates arginine residues.	Arginine	82-90	WD repeat domain 77	Mus musculus	47-52
34730397-3	2022	In this study, we identified a cluster of six arginine residues in the disordered domain of UL34 as a minimal region required for the interaction with ALIX as well as the recruitment of ALIX and an ESCRT-III protein CHMP4B to the INM in HSV-1-infected cells.	Arginine	46-54	programmed cell death 6 interacting protein	Homo sapiens	151-155
34730397-3	2022	In this study, we identified a cluster of six arginine residues in the disordered domain of UL34 as a minimal region required for the interaction with ALIX as well as the recruitment of ALIX and an ESCRT-III protein CHMP4B to the INM in HSV-1-infected cells.	Arginine	46-54	programmed cell death 6 interacting protein	Homo sapiens	186-190
34730397-5	2022	We also showed that the effect of the arginine cluster in UL34 on HSV-1 replication was dependent primarily on ALIX.	Arginine	38-46	programmed cell death 6 interacting protein	Homo sapiens	111-115
34730397-6	2022	These results indicated that the arginine cluster in the disordered domain of UL34 was required for the interaction with ALIX and the recruitment of ESCRT-III machinery to the INM to promote primary envelopment.	Arginine	33-41	programmed cell death 6 interacting protein	Homo sapiens	121-125
34730397-10	2022	In this study, we present data suggesting that the arginine cluster in the disordered domain of HSV-1 UL34 mediates the interaction with ALIX, thereby leading to the recruitment of ESCRT-III machinery to the INM for efficient primary envelopment.	Arginine	51-59	programmed cell death 6 interacting protein	Homo sapiens	137-141
34170347-4	2022	With labeled probes, we find evidence that toxic arginine-rich DPRs (poly-GR and poly-PR), but not the non-toxic poly-GP, target NPC hydrogel mimics and block selective entry of a key nuclear transport receptor, importin beta (Impbeta).	Arginine	49-57	inositol monophosphatase 1	Homo sapiens	227-234
34957901-3	2021	Here we report a mutation in exon 3 of the beta-globin gene, which results in an unstable globin (Hb Dieppe) (beta127(H5)Gln Arg; HBB: c.383A>G) with a dominant beta-thal phenotype in two generations of a Chinese family.	Arginine	125-128	hemoglobin subunit beta	Homo sapiens	130-133
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	3-11	ubiquitin-like with PHD and ring finger domains 1 S homeolog	Xenopus laevis	190-195
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	28-31	ubiquitin-like with PHD and ring finger domains 1 S homeolog	Xenopus laevis	190-195
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	145-148	ubiquitin-like with PHD and ring finger domains 1 S homeolog	Xenopus laevis	190-195
34423886-4	2021	Here, two mouse models were used to investigate the protective effects of limonin on AP, the caerulein-induced mild acute pancreatitis (MAP) model and L-arginine-induced severe AP (SAP) model.	Arginine	151-161	LIM homeobox protein 2	Mus musculus	177-179
34279997-9	2021	Besides, the nonsynonymous mutations existed in four ARGs in different strains, including CatB (Pro165Ser, Gly208Asp), VmeA (Ile313Thr), VmeC (Glu329Ala), and VmeD (Asn205Ser).	Arginine	53-57	multidrug efflux RND transporter periplasmic adaptor subunit VmeC	Vibrio parahaemolyticus	137-141
34383999-1	2021	HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine.	Arginine	97-105	major histocompatibility complex, class I, B	Homo sapiens	0-5
34383999-1	2021	HLA-B*46:64 has one nucleotide change from HLA-B*46:01:01:01 where Histidine (113) is changed to Arginine.	Arginine	97-105	major histocompatibility complex, class I, B	Homo sapiens	43-48
34627806-9	2021	In the competitive (3H)VAT ARG with human striatal sections, strong ARG signals in caudate and putamen were blocked significantly by either VAChT ligand TZ659 or (-)-vesamicol, but not by the sigma1 receptor ligand Yun-122.	Arginine	27-30	solute carrier family 18 member A3	Homo sapiens	140-145
34627806-9	2021	In the competitive (3H)VAT ARG with human striatal sections, strong ARG signals in caudate and putamen were blocked significantly by either VAChT ligand TZ659 or (-)-vesamicol, but not by the sigma1 receptor ligand Yun-122.	Arginine	68-71	solute carrier family 18 member A3	Homo sapiens	140-145
34752483-5	2021	Biochemical analysis revealed that the CpAM-resistant mutations in the context of precore protein (p25) did not affect the levels of p22 produced by signal peptidase removal of N-terminal 19 amino acid residues, but significantly reduced p17, which is produced by furin cleavage of C-terminal arginine-rich domain of p22 and secreted as HBeAg.	Arginine	293-301	calcineurin like EF-hand protein 1	Homo sapiens	317-320
34363436-1	2021	Peptidylarginine deiminases 4 (PAD4), a kind of enzyme capable of converting protein arginine or mono-methylarginine into citrulline, has been identified to display a key role in diverse diseases.	Arginine	85-93	peptidyl arginine deiminase 4	Homo sapiens	0-29
34363436-1	2021	Peptidylarginine deiminases 4 (PAD4), a kind of enzyme capable of converting protein arginine or mono-methylarginine into citrulline, has been identified to display a key role in diverse diseases.	Arginine	85-93	peptidyl arginine deiminase 4	Homo sapiens	31-35
34358365-3	2021	METHODS: Prognostic ARG candidates were identified by univariate and multivariate Cox regression analysis in the training dataset (TCGA-HNSC) and incorporated into a 3-ARGs (EGFR, FADD, PARK2) prognostic signature which was further verified in two independent validation cohorts (GSE41613 and GSE42743).	Arginine	20-23	Fas associated via death domain	Homo sapiens	180-184
34358365-3	2021	METHODS: Prognostic ARG candidates were identified by univariate and multivariate Cox regression analysis in the training dataset (TCGA-HNSC) and incorporated into a 3-ARGs (EGFR, FADD, PARK2) prognostic signature which was further verified in two independent validation cohorts (GSE41613 and GSE42743).	Arginine	20-23	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	186-191
34583098-0	2021	Arginine methylation by PRMT2 promotes IFN-beta production through TLR4/IRF3 signaling pathway.	Arginine	0-8	toll like receptor 4	Homo sapiens	67-71
34583098-3	2021	In this study, we found that protein arginine methyltransferase 1, 2 and 3 (PRMT1, 2 and 3) were recruited to methylate TLR4-CD (cytoplasmic domain) after lipopolysaccharide (LPS) stimulation respectively, but the effect of PRMT2 on arginine methylation of TLR4-CD is the most significant among above three PRMTs, which prompted us to focus on PRMT2.	Arginine	233-241	toll like receptor 4	Homo sapiens	120-124
34583098-3	2021	In this study, we found that protein arginine methyltransferase 1, 2 and 3 (PRMT1, 2 and 3) were recruited to methylate TLR4-CD (cytoplasmic domain) after lipopolysaccharide (LPS) stimulation respectively, but the effect of PRMT2 on arginine methylation of TLR4-CD is the most significant among above three PRMTs, which prompted us to focus on PRMT2.	Arginine	233-241	toll like receptor 4	Homo sapiens	257-261
34583098-4	2021	Reduction of PRMT2 expression down-regulated arginine (R) methylation level of TLR4 with or without LPS treatment.	Arginine	45-53	toll like receptor 4	Homo sapiens	79-83
34583098-5	2021	Methionine 115 (M115) mediated PRMT2 catalyzed-arginine methylation of TLR4 on R731 and R812.	Arginine	47-55	toll like receptor 4	Homo sapiens	71-75
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	0-8	toll like receptor 4	Homo sapiens	24-28
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	0-8	toll like receptor 4	Homo sapiens	110-114
34583098-7	2021	Arginine methylation of TLR4 on R812 or arginine methylation of IRF3 on R285 mediated the interaction between TLR4 and IRF3 respectively.	Arginine	40-48	toll like receptor 4	Homo sapiens	110-114
34583098-9	2021	In addition, the enhancement of arginine methylation of TLR4 induced by PRMT1 or 2 increased IRF3 transcription activity with or without LPS treatment, while PRMT2 with histidine 112 glutamine (H112Q) or methionine 115 isoleucine (M115I) mutation and TLR4 with arginine 812 lysine (R812K) mutation decreased it.	Arginine	32-40	toll like receptor 4	Homo sapiens	56-60
34583098-10	2021	Arginine methylation of TLR4 on R812 or PRMT2 enhanced interferon-beta (IFN-beta) production.	Arginine	0-8	toll like receptor 4	Homo sapiens	24-28
34833008-0	2021	Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons.	Arginine	43-51	protein arginine methyltransferase 8	Homo sapiens	29-34
34309734-7	2021	Hence, the administration of Arg depriving enzymes (ADE) such as arginase, arginine decarboxylase (ADC), and arginine deiminase (ADI) could be effective in cancer therapy.	Arginine	29-32	antizyme inhibitor 2	Homo sapiens	75-97
34658931-4	2021	In mammals, mainly two organs express OTC: the liver, where it is an integral part of the urea cycle, and the intestine, where it synthesizes citrulline for export and plays a major role in amino acid homeostasis, particularly of L-glutamine and L-arginine.	Arginine	246-256	ornithine transcarbamylase	Homo sapiens	38-41
34559973-7	2022	The results showed that miR-297 antagomir repressed the apoptosis and inflammation induced by H/R treatment in THLE-2 cells.	Arginine	96-97	microRNA 297	Homo sapiens	24-31
34551290-0	2021	The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation.	Arginine	89-97	protein arginine N-methyltransferase 1	Mus musculus	39-44
34399903-6	2021	The hydroxylamine moiety in this resin is combined with a peptide linker (GRG) containing an arginine residue to enhance the ionization efficiency.	Arginine	93-101	TLE family member 5, transcriptional modulator	Homo sapiens	74-77
34184805-0	2021	Snail enhances arginine synthesis by inhibiting ubiquitination-mediated degradation of ASS1.	Arginine	15-23	argininosuccinate synthase 1	Homo sapiens	87-91
34184805-7	2021	Collectively, these findings suggest that TGF-beta and Snail promote arginine synthesis via inhibiting LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly and this complex can serve as potential target for the development of new therapeutic approaches to treat CRC.	Arginine	69-77	argininosuccinate synthase 1	Homo sapiens	135-139
34373747-10	2021	Mechanically, WDR77 enhanced PRMT5-triggered symmetric dimethylation of arginine 3 on H4 (H4R3me2s) on the cccDNA minichromosome to control cccDNA transcription.	Arginine	72-80	WD repeat domain 77	Homo sapiens	14-19
34336668-2	2021	Serine and arginine rich splicing factor 9 (SFRS9) is frequently described as a proto-oncogene in cervical and bladder cancer.	Arginine	11-19	serine and arginine rich splicing factor 9	Homo sapiens	44-49
34224011-6	2021	The metal ionic radii were acting on calculated sorption capacity and that sorption efficiency related to ionic radii of metal was as follows: R(Ni2+) <= R(Cd2+) < R(Cu2+) < R(Pb2+).	Arginine	154-155	CD2 molecule	Homo sapiens	156-159
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	apolipoprotein C3	Homo sapiens	68-73
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	erythropoietin receptor	Homo sapiens	75-79
34281234-9	2021	Mutations in some of these genes of the splicing machinery, such as Serine and Arginine Rich Splicing Factor A3 and B3 (SF3A3, SF3B3), were significantly enriched in melanomas as compared to benign nevi.	Arginine	79-87	splicing factor 3a subunit 3	Homo sapiens	93-118
34281234-9	2021	Mutations in some of these genes of the splicing machinery, such as Serine and Arginine Rich Splicing Factor A3 and B3 (SF3A3, SF3B3), were significantly enriched in melanomas as compared to benign nevi.	Arginine	79-87	splicing factor 3a subunit 3	Homo sapiens	120-125
34281234-9	2021	Mutations in some of these genes of the splicing machinery, such as Serine and Arginine Rich Splicing Factor A3 and B3 (SF3A3, SF3B3), were significantly enriched in melanomas as compared to benign nevi.	Arginine	79-87	splicing factor 3b subunit 3	Homo sapiens	127-132
34616867-2	2021	PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.	Arginine	43-51	peptidyl arginine deiminase 1	Homo sapiens	0-5
34140951-6	2021	Citrullination is mediated by calcium-dependent peptidylarginine deiminase (PAD) enzymes, which catalyze deimination, the conversion of arginine into the non-classical amino acid citrulline.	Arginine	136-144	peptidyl arginine deiminase 4	Homo sapiens	76-79
34233561-1	2021	Hb Tacoma (beta30(B12)Arg Ser) is a missense variant that is caused by either an AGG>AGT or AGG>AGC substitution at codon 30 of the HBB gene.	Arginine	22-25	hemoglobin subunit beta	Homo sapiens	132-135
34251644-1	2021	As a functional amino acid (AA), L-arginine (Arg) serves not only as a building block of protein but also as an essential substrate for the synthesis of nitric oxide (NO), creatine, polyamines, homoarginine, and agmatine in mammals (including humans).	Arginine	33-43	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	45-48
34397320-9	2021	Molecular docking and MDS analyses revealed that among these molecules, the tripeptide Arg-His-Trp shows a favorable binding affinity with beta2AR (-9.8 Kcal/mol).	Arginine	87-90	adenosine A2a receptor	Homo sapiens	139-146
34397320-12	2021	This unique tripeptide Arg-His-Trp is suggested to be a potential agonist of beta2AR and it may have applications in the context of various human diseases like bronchial asthma and chronic obstructive pulmonary disease (COPD).	Arginine	23-26	adenosine A2a receptor	Homo sapiens	77-84
35598654-5	2022	In summary, we demonstrated that significant injury had already took place at 3 h of MI/R, which could be ameliorated by SevoPre via promoting affinity of adiponectin receptor 1 and ceveolin-3, and then attenuating endoplasmic reticulum stress of cardiomyocytes.	Arginine	88-89	adiponectin receptor 1	Mus musculus	155-177
35477090-0	2022	FXR/ASS1 axis attenuates the TAA-induced liver injury through arginine metabolism.	Arginine	62-70	argininosuccinate synthase 1	Homo sapiens	4-8
35477090-3	2022	In this study, we found that Argininosuccinate synthetase 1 (ASS1), a rate-limiting enzyme in arginine metabolism, was downregulated in the TAA-induced liver injury model.	Arginine	94-102	argininosuccinate synthase 1	Homo sapiens	29-59
35477090-3	2022	In this study, we found that Argininosuccinate synthetase 1 (ASS1), a rate-limiting enzyme in arginine metabolism, was downregulated in the TAA-induced liver injury model.	Arginine	94-102	argininosuccinate synthase 1	Homo sapiens	61-65
35477090-8	2022	Taken together, our study illustrated a protective role of the FXR/ASS1 axis in TAA-induced liver injury by targeting arginine metabolism, which might shed light on the development of novel therapeutic approaches for acute liver injury.	Arginine	118-126	argininosuccinate synthase 1	Homo sapiens	67-71
35354305-7	2022	eNOS (endothelial nitric oxide synthase) activity was accessed by heavy arginine/citrulline LC-MS/MS detection and phosphorylation of serine1177 in aortic rings.	Arginine	72-80	nitric oxide synthase 3, endothelial cell	Mus musculus	0-4
35354305-7	2022	eNOS (endothelial nitric oxide synthase) activity was accessed by heavy arginine/citrulline LC-MS/MS detection and phosphorylation of serine1177 in aortic rings.	Arginine	72-80	nitric oxide synthase 3, endothelial cell	Mus musculus	6-39
35380161-5	2022	ADP-ribosylation on arginine and serine is reversed by ARH1 and ARH3 respectively, whereas macrodomain-containing MACROD1, MACROD2 and TARG1 reverse modification of acidic residues.	Arginine	20-28	ADP-ribosylserine hydrolase	Homo sapiens	64-68
35549216-4	2022	Acylation occurred in two stages: (i) proton transfer from Ser441 to His296 concerted with the nucleophilic attack of Ser441 to the substrate"s P1-Arg and (ii) proton transfer from His296 to the P1"-Ser residue concerted with the cleavage of the ArgP1-SerP1" peptide bond, with a Gibbs activation energy of 17.1 and 15.8 kcal mol-1, relative to the reactant.	Arginine	147-150	diacylglycerol O-acyltransferase 1	Homo sapiens	246-251
35597930-5	2022	MFG-E8 is a secreted protein with NH2-terminal epidermal growth factor (EGF)-like domains, containing an Arg-Gly-Asp(RGD) sequence that binds alphavbeta3 and alphavbeta5 integrins, and COOH terminal domains C1 and C2, which can bind to lipid membrane with strong affinity.	Arginine	105-108	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-6
35590365-10	2022	CONCLUSIONS: These above results provide new insight that arginine protects hepatocytes against inflammation induced by FAdV-4 through JAK2/STAT3 signaling pathway.	Arginine	58-66	Janus kinase 2	Gallus gallus	135-139
35339936-5	2022	Arg supplementation linearly upregulated (P < 0.05) the gonadotropin-releasing hormone 1 (GnRH1), and gonadotropin inhibitory hormone in the hypothalamus.	Arginine	0-3	neuropeptide VF precursor	Gallus gallus	102-133
35339936-8	2022	Serum insulin-like growth factor 1 (IGF-1) and nitric oxide (NO) were increased (P < 0.05) at higher levels of Arg supplementation.	Arginine	111-114	insulin like growth factor 1	Gallus gallus	6-34
35339936-8	2022	Serum insulin-like growth factor 1 (IGF-1) and nitric oxide (NO) were increased (P < 0.05) at higher levels of Arg supplementation.	Arginine	111-114	insulin like growth factor 1	Gallus gallus	36-41
35409362-7	2022	The basic amino acid arginine enhances glucagon secretion via voltage-dependent calcium channels (VDCC).	Arginine	21-29	glucagon	Cricetulus griseus	39-47
35409362-9	2022	Interestingly, the knockdown of Pkcdelta in InR1G9 cells reduced arginine-induced glucagon secretion.	Arginine	65-73	glucagon	Cricetulus griseus	82-90
35124444-1	2022	Guanidinoacetic acid (GAA) is the direct precursor of creatine and can spare arginine (Arg) for creatine synthesis in low crude protein (CP) broiler diets.	Arginine	77-85	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	87-90
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Arginine	51-54	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	23-27
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Arginine	85-93	protein phosphatase 1 regulatory subunit 10	Homo sapiens	118-123
35325178-5	2022	When coupled with the amyotrophic lateral sclerosis (ALS)-associated C9ORF72 proline/arginine-rich dipeptide repeats, pNUTs allow us to photomanipulate poly-proline-arginine nucleolar localization, perturb nucleolar protein nucleophosmin 1 and suppress nascent protein synthesis.	Arginine	165-173	protein phosphatase 1 regulatory subunit 10	Homo sapiens	118-123
35199998-3	2022	Herein, a kind of nitric oxide (NO)-driven carrier-free nanomotor based on the reaction between trehalose (Tr, one of the mTOR-independent autophagy inducers), L-arginine (Arg), and phosphatidylserine (PS) is reported.	Arginine	160-170	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	172-175
35448460-8	2022	Whereas BI01383298 inhibited only human NaCT-mediated citrate uptake, it inhibits the uptake of arginine and derivatives mediated by both human NaCT and mouse Nact.	Arginine	96-104	solute carrier family 13 member 5	Homo sapiens	144-148
35448460-9	2022	In contrast, the prototypic substrate citrate inhibited the transport of arginine and derivatives mediated only by human NaCT.	Arginine	73-81	solute carrier family 13 member 5	Homo sapiens	121-125
35300428-7	2022	A five ARG-based signature, including A2M, CHEK2, ELN, FOS, and PLAU, was constructed in the TCGA dataset, and stratified patients into low- and high-risk groups with significantly different overall survival (OS) rates.	Arginine	7-10	alpha-2-macroglobulin	Homo sapiens	38-41
35177655-8	2022	Heterozygous pathogenic COL4A3 and COL4A4 variants that resulted in a Gly substitution with a highly destabilising residue (Arg, Val, Glu, Asp, Trp) were associated with an increased risk of haematuria (p = 0.018), and those adjacent to a non-collagenous region were associated with a reduced risk (p = 0.046).	Arginine	124-127	collagen type IV alpha 3 chain	Homo sapiens	24-30
35115608-3	2022	Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center on blocking the WIN site of WDR5, an arginine binding cavity that engages MLL/SET enzymes that deposit histone H3 lysine 4 methylation (H3K4me).	Arginine	130-138	lysine methyltransferase 2A	Homo sapiens	167-170
35046516-8	2022	The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity, leading to arginine methylation of SREBP1a.	Arginine	79-87	WD repeat domain 77	Homo sapiens	10-15
35046516-8	2022	The PRMT5-Mep50 octamer increases PRMT5 methyltransferase activity, leading to arginine methylation of SREBP1a.	Arginine	79-87	sterol regulatory element binding transcription factor 1	Homo sapiens	103-110
35203411-7	2022	SGLT2 inhibition increased the animal survival rate and reduced plasma glucose, accompanied by sustained human C-peptide levels and improved islet response to glucose/arginine.	Arginine	167-175	solute carrier family 5 member 2	Homo sapiens	0-5
35096831-8	2021	MFG-E8 knockout mice suffered more severe ER stress and greater inflammatory response after L-arginine administration.	Arginine	92-102	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	0-6
34984976-12	2022	Together, these data demonstrate that, through Sm and CHTOP arginine methylation, PRMTs regulate the post-transcriptional processing of nuclear, detained introns.	Arginine	60-68	chromatin target of PRMT1	Homo sapiens	54-59
2557345-3	1989	The arginine residue (Arg187) that is the presumed site of ADP-ribosylation of Gs alpha by cholera toxin has been changed to Ala, Glu, or Lys.	Arginine	4-12	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	79-87
2689869-0	1989	Arginine restriction induced by delta-N-(phosphonacetyl)-L-ornithine signals increased expression of HIS3, TRP5, CPA1, and CPA2 in Saccharomyces cerevisiae.	Arginine	0-8	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	101-105
2689869-2	1989	Arginine restriction caused increased expression of HIS3 and TRP5, measured by the beta-galactosidase activity in strains carrying chromosomally integrated fusions of the promoter regions of each gene with the lacZ gene of Escherichia coli.	Arginine	0-8	imidazoleglycerol-phosphate dehydratase HIS3	Saccharomyces cerevisiae S288C	52-56
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Arginine	94-97	tryptase	Canis lupus familiaris	48-56
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Arginine	238-241	tryptase	Canis lupus familiaris	48-56
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Arginine	238-241	tryptase	Canis lupus familiaris	209-217
2677049-6	1989	Asp217 in the substrate binding pocket of human tryptase is consistent with a specificity for Arg and Lys residues at the site of cleavage (P1), whereas Glu245 is consistent with the known preference of human tryptase for substrates with Arg or Lys also at P3, analogous residues also being present in dog tryptase.	Arginine	238-241	tryptase	Canis lupus familiaris	209-217
2692595-4	1989	Limited proteolysis with thrombin resulted in the cleavage of only a single peptide bond between arginine-132 and alanine-133 in bovine somatotropin dimer.	Arginine	97-105	coagulation factor II, thrombin	Bos taurus	25-33
2479017-6	1989	A single T----C transition results in the substitution of a charged amino acid residue, arginine, for tryptophan in one of the four extremely hydrophobic domains of the PLP protein.	Arginine	88-96	proteolipid protein 1	Homo sapiens	169-172
2552437-5	1989	In contrast, the KRAS protein, which carries an extremely basic domain (residues 172-182, Lys-Asp-Glu-Lys6-Ser-Arg), is phosphorylated by the receptor kinase without the addition of basic proteins.	Arginine	111-114	KRAS proto-oncogene, GTPase	Homo sapiens	17-21
2819035-15	1989	In horse alcohol dehydrogenase and beta 1 beta 1, the guanidino group of Arg-369 is thought to stabilize the NAD(H)-enzyme complex by bonding to one of the pyrophosphate oxygens.	Arginine	73-76	aldo-keto reductase family 1 member A1	Homo sapiens	9-30
2474786-0	1989	Characterization of monoclonal antibody R256, specific for activated ras p21 with arginine at 12, and analysis of breast carcinoma of v-Harvey-ras transgenic mouse.	Arginine	82-90	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	73-76
2478116-4	1989	A number of agents which inhibit monocyte C1-inh production (such as histamine, PGE2 C5a des arg and serum treated immune complexes) bind to membrane receptors, activate adenylate cyclase, elevate intracellular cAMP and activate cAMP-dependent protein kinase.	Arginine	93-96	serpin family G member 1	Homo sapiens	42-48
2775495-3	1989	The new beta-lactoglobulin C is a subtype of ovine beta-lactoglobulin A with a single exchange Arg-Gln at position 148.	Arginine	95-98	beta-lactoglobulin	Bos taurus	8-28
2775495-3	1989	The new beta-lactoglobulin C is a subtype of ovine beta-lactoglobulin A with a single exchange Arg-Gln at position 148.	Arginine	95-98	beta-lactoglobulin	Bos taurus	8-26
2567185-4	1989	Examination of the sites phosphorylated on acetyl-CoA carboxylase, hormone-sensitive lipase, glycogen synthase and phosphorylase kinase suggests a consensus recognition sequence in which the serine residue phosphorylated by the AMP-activated protein kinase has a hydrophobic residue on the N-terminal side (i.e., at -1) and at least one arginine residue at -2, -3 or -4.	Arginine	337-345	lipase E, hormone sensitive type	Homo sapiens	67-91
2656711-3	1989	Canavanine replacement for arginine causes a total loss of detectable antibacterial activity for diptericin B and diptericin C, whereas diptericin A and peak V protein are severely inhibited.	Arginine	27-35	Diptericin A	Drosophila melanogaster	97-107
2773809-8	1989	Clustering was also induced by the addition of the GPIIb-IIIa binding domains of fibrinogen--namely, the tetrapeptide Arg-Gly-Asp-Ser on the alpha-chain or the gamma-chain decapeptide gamma 402-411.	Arginine	118-121	integrin subunit alpha 2b	Homo sapiens	51-56
2496661-10	1989	This alignment was facilitated by identification of a helical collagen crossing site consisting of Hyl-Gly-His-Arg located at positions 87-90 in all collagen chains of this size thus far identified.	Arginine	111-114	megakaryocyte-associated tyrosine kinase	Homo sapiens	99-102
2504277-5	1989	The tryptase sequence includes the essential residues of the catalytic triad and an aspartic acid at the base of the putative substrate binding pocket that confers P1 Arg and Lys specificity on tryptic serine proteases.	Arginine	167-170	tryptase	Canis lupus familiaris	4-12
2497461-4	1989	As shown previously, pure PK-C phosphorylates a synthetic random polymer of arginine and serine in the absence of Ca2+ and lipids, a reaction markedly stimulated by an endogenous unidentified activator of PK-C.	Arginine	76-84	protein kinase C, gamma	Rattus norvegicus	26-30
2497461-4	1989	As shown previously, pure PK-C phosphorylates a synthetic random polymer of arginine and serine in the absence of Ca2+ and lipids, a reaction markedly stimulated by an endogenous unidentified activator of PK-C.	Arginine	76-84	protein kinase C, gamma	Rattus norvegicus	205-209
2703483-0	1989	Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.	Arginine	34-42	membrane metallo-endopeptidase	Rattus norvegicus	50-77
2703483-0	1989	Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.	Arginine	34-42	membrane metallo-endopeptidase	Rattus norvegicus	79-92
2703483-0	1989	Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.	Arginine	97-105	membrane metallo-endopeptidase	Rattus norvegicus	50-77
2703483-0	1989	Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.	Arginine	97-105	membrane metallo-endopeptidase	Rattus norvegicus	79-92
2703483-1	1989	Neutral endopeptidase 24.11 contains an active-site arginine residue involved in binding the free carboxylate of substrate peptides and inhibitors.	Arginine	52-60	membrane metallo-endopeptidase	Rattus norvegicus	0-27
2742826-2	1989	At pH 5.3 and 25 degrees C, the Arg(16)-Gly(17) peptide bonds of both peptides F10 and F13 were cleaved instantaneously in the presence of 0.6 mM thrombin, whereas the cleavage of the Arg(19)-Val(20) peptide bonds in peptides F12, F13, and F14 took over 1 h for completion.	Arginine	32-35	coagulation factor XII	Homo sapiens	226-229
2752493-7	1989	These results suggest that the rise in the urinary excretion of GAA on the 1st day was ascribable to an inhibitory effect of cephaloridine on renal reabsorption of GAA, and that the fall in its urinary excretion on the 3rd day was ascribable to the suppression in the renal GAA formation system including GAT, arginine and so on.	Arginine	310-318	alpha glucosidase	Rattus norvegicus	64-67
2464704-6	1989	The env precursor polyprotein gp160 is cleaved between arginine 526 and glycine 527 to give rise to the external glycoprotein and the transmembrane of SIVMAC.	Arginine	55-63	envelope protein	Simian immunodeficiency virus	4-7
2928301-0	1989	Brain protein kinase C phosphorylating poly(arginine,serine) or lamin B is stimulated by anions and by an activator purified from bovine serum albumin preparations.	Arginine	44-52	protein kinase C, gamma	Rattus norvegicus	6-22
2928301-3	1989	The phosphorylation ratio of histone to poly(arginine,serine) varies between different PK-C fractions from brains of rat, pig, or lamb.	Arginine	45-53	protein kinase C, gamma	Rattus norvegicus	87-91
2466334-3	1989	The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues.	Arginine	112-120	amphiregulin	Homo sapiens	27-39
2644270-10	1989	Hence, the carboxylate group of FA bound to I-FABP was solvent inaccessible and most likely involved in an ion-pair electrostatic interaction with the delta-guanidinium moiety of an Arg residue.	Arginine	182-185	fatty acid binding protein 2	Rattus norvegicus	44-50
2913947-5	1989	In addition, the COOH-terminal sequence of the rat tropoelastin is virtually identical to tropoelastins of other species in possessing a cysteine/arginine/lysine containing segment.	Arginine	146-154	elastin	Rattus norvegicus	51-63
2912975-8	1989	These results establish that COOH-terminal residues 116-128 are not essential for the electron transfer activity of bovine adrenodoxin, and the differential effects of truncation at Arg-115 on interactions with adrenodoxin reductase and cytochromes P-450 suggest that the residues involved in the interactions are not identical.	Arginine	182-185	ferredoxin reductase	Bos taurus	211-232
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Arginine	74-77	kallikrein related peptidase 4	Homo sapiens	39-49
2603816-5	1989	It has been shown from the sequence of kallikrein that Arg(-1)-Ile(1) and Arg(87)-Gln(88) bonds are hydrolyzed with trypsin on rapid activation of prokallikrein and the formation of disulfide-linked two chain kallikrein.	Arginine	74-77	kallikrein related peptidase 4	Homo sapiens	150-160
2535976-6	1989	In 8 out of the 12 patients tested, with CMV infection, a decreased hemolytic activity of the alternative pathway (AP50) was found, together with the elevated levels of C3d and C3a des arg.	Arginine	185-188	complement C3	Homo sapiens	177-180
2535976-10	1989	We conclude that our data are consistent with complement activation and the formation of biologically active peptides like C3a des arg in patients with an active CMV infection.	Arginine	131-134	complement C3	Homo sapiens	123-126
2461903-4	1989	Two amino acid residues of HLA-A29.1, gln-144 and arg-151, were found in all 24 HLA-B and HLA-C alleles examined but were present in only one of 15 HLA-A alleles for which sequence data are available.	Arginine	50-53	major histocompatibility complex, class I, C	Homo sapiens	90-95
2461903-8	1989	These observations are consistent with the notion that gln-144 and arg-151 define a determinant common to HLA-B, HLA-C, and the HLA-Aw19 cross-reactive group and the binding site of the monoclonal antibody 4E.	Arginine	67-70	major histocompatibility complex, class I, C	Homo sapiens	113-118
2851659-6	1988	The mutated phenotype that commutes the expression of the two isocytochrome structural genes (superactivation of CYP3 and inhibition of CYC1) results from a transversion in an AGT codon (serine) in the wild-type to an AGG codon (arginine) in the mutant.	Arginine	229-237	peptidylprolyl isomerase CPR3	Saccharomyces cerevisiae S288C	113-117
3053736-7	1988	Although different in activation pathways and recognition specificity, Mac-1 exhibits an oligospecific ligand versatility characteristic of other homologous Arg-Gly-Asp-directed adhesion receptors.	Arginine	157-160	integrin subunit alpha M	Homo sapiens	71-76
2485226-9	1988	Moreover, they provide evidence that the Arg-Gly-Asp sequence is the only, or essential, GP IIb-IIIa binding site in the vWF molecule.	Arginine	41-44	integrin alpha-IIb	Oryctolagus cuniculus	89-95
2846277-6	1988	The rad3 Arg-48 mutant is apparently defective in a step subsequent to incision at the damage site in DNA; it can incise UV damaged DNA, but does not remove pyrimidine dimers.	Arginine	9-12	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	4-8
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Arginine	156-166	NBL1, DAN family BMP antagonist	Mus musculus	135-138
3071743-7	1988	Moreover, GRP increased the plasma glucagon levels during infusion of both arginine and glucose.	Arginine	75-83	gastrin releasing peptide	Rattus norvegicus	10-13
3071743-8	1988	In summary, in the rat GRP 1) stimulates basal insulin and glucagon secretion, 2) potentiates glucose-stimulated insulin secretion, 3) inhibits arginine-stimulated insulin secretion, 4) potentiates arginine-stimulated glucagon secretion, 5) counteracts the glucose-induced suppression of glucagon secretion, and 6) induces hyperglycemia.	Arginine	144-152	gastrin releasing peptide	Rattus norvegicus	23-26
3071743-8	1988	In summary, in the rat GRP 1) stimulates basal insulin and glucagon secretion, 2) potentiates glucose-stimulated insulin secretion, 3) inhibits arginine-stimulated insulin secretion, 4) potentiates arginine-stimulated glucagon secretion, 5) counteracts the glucose-induced suppression of glucagon secretion, and 6) induces hyperglycemia.	Arginine	198-206	gastrin releasing peptide	Rattus norvegicus	23-26
3051138-5	1988	At a concentration of 1.0 nM, GLP-1-(7-36 amide) also enhanced insulin secretion induced by 5 mM L-arginine whereas at concentrations of up to 10.0 nM, GLP-1-(1-37) did not.	Arginine	97-107	glucagon	Rattus norvegicus	30-35
3196529-8	1988	C3a des Arg and C5a des Arg generation decreased 75% and 86%, respectively, as the polyvinylpyrolidone content of the casting solution was increased from 25 to 50%.	Arginine	8-11	complement C3	Homo sapiens	0-3
3196529-8	1988	C3a des Arg and C5a des Arg generation decreased 75% and 86%, respectively, as the polyvinylpyrolidone content of the casting solution was increased from 25 to 50%.	Arginine	24-27	complement C3	Homo sapiens	0-3
3392212-5	1988	Vitamin D-binding protein enhanced the chemotactic activity of native C5a des Arg, but had no effect on the chemotactic activity of either native C5a or FMLP.	Arginine	78-81	GC vitamin D binding protein	Homo sapiens	0-25
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	Arginine	114-117	GC vitamin D binding protein	Homo sapiens	42-67
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	Arginine	143-146	GC vitamin D binding protein	Homo sapiens	147-172
3392213-0	1988	Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.	Arginine	104-107	GC vitamin D binding protein	Homo sapiens	0-11
3392213-0	1988	Gc-globulin (vitamin D-binding protein) enhances the neutrophil chemotactic activity of C5a and C5a des Arg.	Arginine	104-107	GC vitamin D binding protein	Homo sapiens	13-38
3392213-4	1988	However, as little as 0.01 nM Gc-globulin greatly enhanced the neutrophil chemotactic activity of C5a and its derivative, C5a des Arg over a wide concentration range.	Arginine	130-133	GC vitamin D binding protein	Homo sapiens	30-41
3392213-10	1988	Finally, radioiodinated C5a or C5a des Arg formed a 1:1 complex with purified Gc-globulin when analyzed by gel filtration chromatography.	Arginine	39-42	GC vitamin D binding protein	Homo sapiens	78-89
3289992-9	1988	In contrast, insulin responses to arginine declined markedly after PX.	Arginine	34-42	insulin	Canis lupus familiaris	13-20
3282947-4	1988	Impairment of intravenous glucose tolerance, loss of the insulin response to glucose and arginine, fasting hyperglucagonemia, exaggerated glucagon responsiveness to arginine, and a significant reduction in sensitivity to insulin were characteristic of all diabetic dogs.	Arginine	89-97	insulin	Canis lupus familiaris	57-64
3382640-2	1988	In addition, an 18 amino acid peptide, aFGF(123-140), is generated, identifying one of the thrombin cleavage sites as the Arg-122/Thr-123 bond.	Arginine	122-125	coagulation factor II, thrombin	Bos taurus	91-99
2837286-0	1988	Involvement of arginine residues in the activation of calmodulin-dependent 3",5"-cyclic-nucleotide phosphodiesterase.	Arginine	15-23	phosphodiesterase 3B	Homo sapiens	81-116
3257998-7	1988	The assay detected both C3a and C3ades arg.	Arginine	39-42	complement C3	Homo sapiens	24-34
2968979-2	1988	The selective inhibition of trypsin, thrombin, factor Xa, and plasmin exhibited by arginine and lysine derivatives has been clearly explained based on the predicted structure and the homology in the amino acid sequences of these enzymes.	Arginine	83-91	coagulation factor X	Homo sapiens	47-56
2449435-2	1988	Liposomes containing platelet glycoproteins IIb-IIIa complex have been shown to bind vitronectin-coated surfaces through an Arg-Gly-Asp cell attachment mechanism.	Arginine	124-127	vitronectin	Homo sapiens	85-96
2449435-7	1988	A synthetic hexapeptide containing the Arg-Gly-Asp sequence inhibited vitronectin binding to platelets.	Arginine	39-42	vitronectin	Homo sapiens	70-81
2906499-4	1988	The acute insulin response (AIR) to an intravenous injection of arginine (2.5 g), which was 4293 +/- 1260 microM min-1 under control conditions, was reduced to 1054 +/- 396 microU min-1 by noradrenaline (P less than 0.01).	Arginine	64-72	insulin	Canis lupus familiaris	10-17
3422188-13	1988	These homologies further establish that GPIIb-IIIa from platelets, together with the vitronectin and the fibronectin receptors, are members of a supergene family of adhesion receptors with a recognition specificity for Arg-Gly-Asp amino acid sequences.	Arginine	219-222	integrin subunit alpha 2b	Homo sapiens	40-45
3422188-13	1988	These homologies further establish that GPIIb-IIIa from platelets, together with the vitronectin and the fibronectin receptors, are members of a supergene family of adhesion receptors with a recognition specificity for Arg-Gly-Asp amino acid sequences.	Arginine	219-222	vitronectin	Homo sapiens	85-96
3347046-0	1988	Interaction of glucocorticoid receptor from rat liver with protamine and arginine.	Arginine	73-81	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	15-38
3347046-2	1988	The nontransformed GR also bound to arginine-Sepharose, but the transformed GR did not bind to either resin.	Arginine	36-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-21
3347046-4	1988	The bindings of GR to protamine- and arginine-Sepharose were saturable.	Arginine	37-45	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	16-18
3347046-5	1988	The apparent dissociation constants of GR on protamine-Sepharose varied from 0.34 nM (-molybdate) to 0.68 nM (+ 10 mM molybdate) and those on arginine-Sepharose were 1.99 nM (-molybdate) and 0.65 nM (+ 10mM molybdate), respectively.	Arginine	142-150	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	39-41
3347046-8	1988	However, the effectiveness of several salts for the elution of GR was consistent in both resins as follows; MgCl2 = CaCl2 = Na2WO4 greater than (NH4)2SO4 = Na2MoO4 greater than arginine-HCl greater than lysine-HCl greater than KCI = NaCl.	Arginine	177-189	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	63-65
3347046-9	1988	These results suggest that GR interacts with arginine residues in protamine.	Arginine	45-53	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	27-29
3693352-1	1987	Peptides containing the tripeptide sequence Arg-Gly-Asp can duplicate or inhibit the cell attachment-promoting effects of fibronectin and vitronectin.	Arginine	44-47	vitronectin	Homo sapiens	138-149
3118957-9	1987	These findings suggest the presence of an essential arginine residue in the substrate-binding domain of aldehyde reductase and the coenzyme-binding site of carbonyl reductase.	Arginine	52-60	aldo-keto reductase family 1 member A1	Homo sapiens	104-122
3577586-2	1987	With this RIA, GLP-1 immunoreactivity (GLP-1 IR) was found to be secreted synchronously with glucagon immunoreactivity upon arginine stimulation from the perfused rat pancreas.	Arginine	124-132	glucagon	Rattus norvegicus	15-20
3577586-4	1987	Moreover HPLC analysis confirmed the presence of GLP-1 IR, which eluted at exactly the same position as synthetic GLP-1, in the perfusate from pancreas perfusion upon stimulation of arginine.	Arginine	182-190	glucagon	Rattus norvegicus	49-54
3577586-4	1987	Moreover HPLC analysis confirmed the presence of GLP-1 IR, which eluted at exactly the same position as synthetic GLP-1, in the perfusate from pancreas perfusion upon stimulation of arginine.	Arginine	182-190	glucagon	Rattus norvegicus	114-119
2436231-1	1987	A highly immunogenic epitope from a conserved COOH-terminal region of the human immunodeficiency virus (HIV) gp120 envelope protein has been identified with antisera from HIV-seropositive subjects and a synthetic peptide (SP-22) containing 15 amino acids from this region (Ala-Pro-Thr-Lys-Ala-Lys-Arg-Arg-Val-Val-Gln-Arg-Glu-Lys-Arg).	Arginine	297-300	peroxiredoxin 3	Homo sapiens	222-227
3546307-4	1987	Each substrate contained a P1 arginine residue, and the effect of various groups and amino acids in the P2, P3, P4, and P5 positions was determined using kcat/Km values to compare reactivities.	Arginine	30-38	protein disulfide isomerase family A member 6	Homo sapiens	104-122
3643926-2	1987	Sequencing of the NH2-terminal region of the light chain reported herein identified the third kallikrein cleavage site of high molecular weight kininogen as Arg-437.	Arginine	157-160	kallikrein related peptidase 4	Homo sapiens	94-104
3469204-2	1987	The peptide was designed to be triple helical and to contain the sequence Arg-Gly-Asp, which has been implicated as the cell attachment site of fibronectin, vitronectin, fibrinogen, and von Willebrand factor, and is also present in type I collagen.	Arginine	74-77	vitronectin	Homo sapiens	157-168
2956497-2	1987	The lack of reactivity of 2H2 with amino-terminal truncated ANF peptides implicates the two amino terminal arginine residues of ANF in the 2H2 epitope.	Arginine	107-115	natriuretic peptide A	Rattus norvegicus	128-131
3102434-3	1987	Nucleotide sequence analysis of the activated N-ras showed a single G----C point mutation at the first letter of codon 13, resulting in the coding of arginine instead of glycine.	Arginine	150-158	NRAS proto-oncogene, GTPase	Homo sapiens	46-51
2429832-1	1986	Intravenous infusion of galanin into conscious dogs during ingestion of oral glucose or a mixed meal or during iv infusion of arginine resulted in significant blunting of plasma insulin responses and significant increases in plasma glucose levels compared to those in control experiments.	Arginine	126-134	insulin	Canis lupus familiaris	178-185
2429832-5	1986	These results suggest that in the conscious dog, galanin administration produces a relatively selective, but readily reversible, inhibition of insulin secretion stimulated by oral nutrients or iv arginine.	Arginine	196-204	insulin	Canis lupus familiaris	143-150
3539143-2	1986	An approximately 6,000-fold increase in the second order association rate constant with human thrombin was observed (48 M-1 X s-1 for the normal protein to 3.1 X 10(5) M-1 X s-1 for the arginine mutant), confirming previously observed data using bovine thrombin (Owen, M.C., Brennan, S.O., Lewis, J.H.	Arginine	186-194	coagulation factor II, thrombin	Bos taurus	253-261
3009377-1	1986	Activated c-Ki-ras with a point mutation (GGT to CGT) at codon 12, resulting in the substitution of arginine for glycine, was found in DNA from metastatic pancreatic adenocarcinoma in a lymph node.	Arginine	100-108	KRAS proto-oncogene, GTPase	Homo sapiens	10-18
3009377-1	1986	Activated c-Ki-ras with a point mutation (GGT to CGT) at codon 12, resulting in the substitution of arginine for glycine, was found in DNA from metastatic pancreatic adenocarcinoma in a lymph node.	Arginine	100-108	UDP glycosyltransferase 8	Homo sapiens	49-52
2420006-3	1986	An affinity matrix made of an insolubilized heptapeptide containing the Arg-Gly-Asp sequence selectively binds the platelet membrane glycoprotein IIb/IIIa from detergent extracts of platelets.	Arginine	72-75	integrin subunit alpha 2b	Homo sapiens	115-149
2420006-5	1986	This platelet receptor is related to the previously identified fibronectin and vitronectin receptors in that it recognizes an Arg-Gly-Asp sequence but differs from the other receptors in its wider specificity toward various adhesive proteins.	Arginine	126-129	vitronectin	Homo sapiens	79-90
2421767-2	1986	Anti-fibrin antibody 59D8 which had been elicited by immunization with human beta(1-7) peptide, Gly-His-Arg-Pro-Leu-Asp-Lys, binds to human and canine fibrins but not to bovine, ovine, or porcine fibrins.	Arginine	104-107	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-85
3964100-0	1986	Determination of plasma C3a des Arg levels after blood contact with foreign surfaces.	Arginine	32-35	complement C3	Homo sapiens	24-27
3964100-3	1986	To the authors" knowledge the only presently available C3a des Arg RIA kit is provided by Upjohn Diagnostics (Kalamazoo, MI, U.S.A.), which covers an assay standard range of 20-500 ng/ml.	Arginine	63-66	complement C3	Homo sapiens	55-58
2418828-3	1986	The inhibitor peptides [Ala107]MBP(104-118) and [Ala113]MBP (104-118), containing alanine in place of the arginine recognition sites, apparently inhibited the enzyme noncompetitively with respect to substrates, with IC50 values ranging from 46-145 and 28-62 microM, respectively.	Arginine	106-114	myelin basic protein	Rattus norvegicus	31-34
2418828-3	1986	The inhibitor peptides [Ala107]MBP(104-118) and [Ala113]MBP (104-118), containing alanine in place of the arginine recognition sites, apparently inhibited the enzyme noncompetitively with respect to substrates, with IC50 values ranging from 46-145 and 28-62 microM, respectively.	Arginine	106-114	myelin basic protein	Rattus norvegicus	56-59
2868709-1	1985	N-Acetyl-L-glutamate synthetase (EC 2.3.1.1) catalyses the synthesis of N-acetyl-L-glutamate, an allosteric activator of carbamoyl-phosphate synthetase I in the liver of ureotelic animals, and the first enzyme is activated specifically by arginine.	Arginine	239-247	carbamoyl-phosphate synthase 1	Rattus norvegicus	121-153
2414098-9	1985	The Arg-Gly-Asp sequence appears to constitute the cell attachment site of vitronectin, since it is in the region where we have previously localized the cell attachment site, its presence correlate with cell attachment activity among the insert-coded polypeptides, and because previous results have shown that synthetic peptides containing the Arg-Gly-Asp sequence inhibit the cell attachment function of vitronectin.	Arginine	344-347	vitronectin	Homo sapiens	75-86
3161512-5	1985	These results suggest that the maturation of ANF may require a tryptic-like cleavage after a single Arg residue.	Arginine	100-103	natriuretic peptide A	Rattus norvegicus	45-48
3907014-5	1985	Intravenous administration of CCK-octa in a dose of 20 U/kg did not affect the plasma level of glucagon during saline infusion but exerted a significant rise of extrapancreatic glucagon during arginine infusion.	Arginine	193-201	cholecystokinin	Canis lupus familiaris	30-33
3907014-6	1985	It is concluded from the present experiment that the administration of tetragastrin, caerulein or CCK-octa enhances the release of extrapancreatic glucagon stimulated by arginine infusion while secretin infusion does not affect the secretion of extrapancreatic glucagon.	Arginine	170-178	cholecystokinin	Canis lupus familiaris	98-101
3890754-4	1985	Chymase was also purified from rat peritoneal cells by employing a one-step method involving hydrophobic chromatography on octyl-Sepharose 4B or arginine-Sepharose 4B.	Arginine	145-153	chymase 1	Rattus norvegicus	0-7
2579381-4	1985	These effects were abolished by cleavage of the COOH-terminal arginine by carboxypeptidase B.	Arginine	62-70	carboxypeptidase B1	Homo sapiens	74-92
2938688-0	1985	[Effects of arginine, administered orally, on the endogenous secretion of the STH-somatomedin complex in young human volunteers].	Arginine	12-20	saitohin	Homo sapiens	78-81
3913581-5	1985	Similar experiments were attempted with high molecular weight epidermal growth factor (HMW-EGF), an analogous growth factor complex that can experience a single modification, the release of arginine by carboxypeptidase B from the carboxy terminus of its biological subunit, low molecular weight EGF (LMW-EGF).	Arginine	190-198	carboxypeptidase B1	Homo sapiens	202-220
3885009-6	1985	The rad3-1 mutation changed a glutamic acid to lysine, and the rad3-2 mutation changed a glycine to arginine.	Arginine	100-108	TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3	Saccharomyces cerevisiae S288C	63-67
6525172-1	1984	Chemical modification of amino acid residues with phenylglyoxal, N-ethylmaleimide and diethyl pyrocarbonate indicated that at least one residue each of arginine, cysteine and histidine were essential for the activity of sheep liver serine hydroxymethyltransferase.	Arginine	152-160	serine hydroxymethyltransferase, cytosolic	Ovis aries	232-263
6142577-0	1984	Arginine hydrochloride stimulation of serum potassium and aldosterone is enhanced by somatostatin-28.	Arginine	0-22	somatostatin	Homo sapiens	85-100
6142577-6	1984	SS-28 completely inhibited the arginine-stimulated insulin increase while SS-14 only partially inhibited the insulin increase.	Arginine	31-39	somatostatin	Homo sapiens	0-5
6142577-7	1984	Since insulin opposes the increase in serum potassium by stimulating cellular uptake of this cation, the enhanced rise in serum potassium in response to arginine hydrochloride during the SS-28 infusion is likely due to the potent insulin suppressing effect of SS-28.	Arginine	153-175	somatostatin	Homo sapiens	187-192
6142577-7	1984	Since insulin opposes the increase in serum potassium by stimulating cellular uptake of this cation, the enhanced rise in serum potassium in response to arginine hydrochloride during the SS-28 infusion is likely due to the potent insulin suppressing effect of SS-28.	Arginine	153-175	somatostatin	Homo sapiens	260-265
6608957-4	1984	The C3a receptors on mast cells and basophils probably contain lipophilic groups that interact with the lipophilic side chains of Leu-73 and Leu-75 and charged groups that interact with the carboxylate and guanidinium groups of Arg-77.	Arginine	228-231	complement C3	Homo sapiens	4-7
6695174-2	1984	As a consequence, arginine instead of the normal glycine is incorporated into the K-ras-coded p21 proteins at amino acid position 12.	Arginine	18-26	KRAS proto-oncogene, GTPase	Homo sapiens	82-87
6320014-4	1984	It has also been found to cleave some Phe and Arg bonds in various substrates such as beta-lipotropin (beta-LPH), adrenocorticotropin (ACTH), pro-opiomelanocortin (POMC) and substance P. Here we describe the complete amino acid sequence of rat submaxillary gland, tonin.	Arginine	46-49	proopiomelanocortin	Rattus norvegicus	142-162
6320014-4	1984	It has also been found to cleave some Phe and Arg bonds in various substrates such as beta-lipotropin (beta-LPH), adrenocorticotropin (ACTH), pro-opiomelanocortin (POMC) and substance P. Here we describe the complete amino acid sequence of rat submaxillary gland, tonin.	Arginine	46-49	proopiomelanocortin	Rattus norvegicus	164-168
6320014-4	1984	It has also been found to cleave some Phe and Arg bonds in various substrates such as beta-lipotropin (beta-LPH), adrenocorticotropin (ACTH), pro-opiomelanocortin (POMC) and substance P. Here we describe the complete amino acid sequence of rat submaxillary gland, tonin.	Arginine	46-49	kallikrein 1-related peptidase C2	Rattus norvegicus	264-269
6423600-3	1984	Addition of arginine decreased (P less than .01) average daily feed intake (ADFI) and gain (ADG), but had no effect on feed efficiency (G/F).	Arginine	12-20	ADG	Sus scrofa	92-95
6714935-11	1984	Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine.	Arginine	146-154	arginyl aminopeptidase	Homo sapiens	48-64
6325477-0	1984	Differential effect of arginine modification with 1,2-cyclohexanedione on the capacity of vimentin and desmin to assemble into intermediate filaments and to bind to nucleic acids.	Arginine	23-31	vimentin	Mus musculus	90-98
6325477-1	1984	When the intermediate filament proteins vimentin and desmin were reacted for a short period of time with the arginine-specific reagent 1,2-cyclohexanedione, the modification had a severe, inhibitory effect on the assembly of intermediate filaments and on the susceptibility of the basic, amino-terminal polypeptide of both proteins to degradation by the intermediate filament-specific, Ca2+-activated proteinase.	Arginine	109-117	vimentin	Mus musculus	40-48
6556144-2	1983	Bradykinin is destroyed by two enzymes: a plasma carboxypeptidase (anaphylatoxin inactivator) removes the COOH-terminal arginine to yield an inactive octapeptide, and a dipeptidase (identical to the angiotensin-converting enzyme) removes the COOH-terminal Phe-Arg to yield a fragment of seven amino acids that is further fragmented to an end product of five amino acids.	Arginine	120-128	carboxypeptidase N subunit 1	Homo sapiens	67-92
6604123-4	1983	Removal of the C-terminus arginine from C3a abolished anaphylotoxin activity but did not affect the platelet-stimulating activity of the peptide.	Arginine	26-34	complement C3	Homo sapiens	40-43
6852239-1	1983	The amino acid sequence of a newly isolated pentapeptide, neo-kyotorphin from bovine brain was synthetically verified to be Thr-Ser-Lys-Tyr-Arg corresponding to the C-terminal portion of hemoglobin alpha-chain.	Arginine	140-143	hemoglobin subunit alpha	Bos taurus	187-209
6404277-1	1983	Biproduct analogs of lysine and arginine are potent inhibitors of enkephalin convertase, a carboxypeptidase B-like enzyme which appears to be physiologically associated with enkephalin biosynthesis.	Arginine	32-40	carboxypeptidase B1	Homo sapiens	91-109
6404277-3	1983	These dicarboxylic acid analogs of arginine are several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase B or N. Kinetic analysis indicates the pure competitive nature of the inhibition.	Arginine	35-43	carboxypeptidase B1	Homo sapiens	124-142
6687626-7	1983	As is the case for the bovine arginine-vasopressin-neurophysin II (AVP-NpII) precursor, the signal sequence of the OT-NpI precursor is immediately followed by the nonapeptide hormone which is connected to neurophysin I by a Gly-Lys-Arg sequence.	Arginine	232-235	arginine vasopressin	Bos taurus	67-75
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Arginine	388-391	neurotensin	Bos taurus	41-52
6822571-1	1983	A new biologically active peptide of the neurotensin (NT) family, shown previously to cross-react in a COOH-terminal-directed radioimmunoassay for bovine NT, has been isolated from extracts of chicken intestine and identified as H-Lys-Asn-Pro-Tyr-Ile-Leu-OH, which is identical with the biologically active COOH-terminal half of NT except for the amino acid substitutions Lys/Arg and Asn/Arg.	Arginine	388-391	neurotensin	Bos taurus	54-56
6838888-4	1983	The best substrates for thrombin were identified as those with arginine in the P1 position, proline or a proline homolog in the P2 position, and an apolar amino acid in the P3 position.	Arginine	63-71	coagulation factor II, thrombin	Bos taurus	24-32
6362333-6	1983	PYY at the dose of 100 pmol/kg X min was without effect on basal insulin and glucagon levels and on glucose-induced insulin release, but exerted an inhibitory effect on arginine-induced secretion of both insulin and glucagon.	Arginine	169-177	peptide YY	Rattus norvegicus	0-3
6838919-0	1983	[Modification of arginine residues of glyceraldehyde 3-phosphate dehydrogenase.	Arginine	17-25	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	38-78
6345757-2	1983	The effects of cold exposure on insulin secretion in response to intravenous injections of glucose, butyrate, arginine, glucagon and tolbutamide were examined in ten sheep exposed to a temperature of 0 degree C for 4-13 days.	Arginine	110-118	LOC105613195	Ovis aries	32-39
6345757-5	1983	Cold exposure brought about a significant but only slight decrease in the insulin response to arginine.	Arginine	94-102	LOC105613195	Ovis aries	74-81
6754353-8	1982	The glucagon response to arginine infusion (0.5 g/kg over 30 min, iv) was elevated by cold exposure, whereas the insulin response to arginine tended to be reduced.	Arginine	133-141	LOC105613195	Ovis aries	113-120
6817749-6	1982	Dissociation of the antithrombin-trypsin complex at pH 7.4 followed first-order kinetics with a half-life for the complex of about 80h at 25 degrees C. The complex was rapidly and quantitatively dissociated at pH 11, resulting in the liberation of a modified two-chain form of the inhibitor, cleaved at the same Arg-Ser bond as in modified antithrombin released from complexes with thrombin, Factor Xa and Factor IXa.	Arginine	312-315	coagulation factor II, thrombin	Bos taurus	24-32
6985269-7	1982	Release of carboxyl-terminal arginine residue by carboxypeptidase B, converting C3a into des-Arg77-C3a, did not alter the inhibitory effect displayed by this fragment.	Arginine	29-37	carboxypeptidase B1	Homo sapiens	49-67
6985269-7	1982	Release of carboxyl-terminal arginine residue by carboxypeptidase B, converting C3a into des-Arg77-C3a, did not alter the inhibitory effect displayed by this fragment.	Arginine	29-37	complement C3	Homo sapiens	80-83
6281785-1	1982	alpha-Melanocyte-stimulating hormone (alpha-melanotropin; alpha-MSH) is a linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that reversibly darkens amphibian skins by stimulating melanomsome (pigment granule) dispersion within melanophores.	Arginine	128-131	msh homeobox 1	Mus musculus	64-67
6977086-5	1981	A new series of mercapto derivatives of arginine analogs are introduced as potent and effective inhibitors of SCPN.	Arginine	40-48	carboxypeptidase N subunit 1	Homo sapiens	110-114
7304077-15	1981	Insulin-induced hypoglycaemia, arginine and ornithine administration resulted in inconsistent and sluggish GH increment.	Arginine	31-39	somatotropin	Canis lupus familiaris	107-109
7342602-1	1981	Peptidyl chloromethyl ketones, largely derived from arginine, inactivate cathepsin B (beef spleen) at rates that vary 300 fold according to sequence, but the residue in the P1 position is not responsible for this variation since homoarginine or nitroarginine in this position provide inhibitors as good or better than those containing arginine.	Arginine	52-60	cathepsin B	Homo sapiens	73-84
7329823-7	1981	The Arg and Pro substitutions in the amino terminal region can explain poor crossreactivity of rat gastrin with antibodies specific for the amino-terminal portion of porcine or human gastrin and its more basic chromatography pattern on ion exchange resins.	Arginine	4-7	gastrin	Rattus norvegicus	99-106
7447415-4	1980	Replacement of the L-arginine moiety of CAE by L-lysine did not decrease the HBsAg-inactivating effect of CAE, whereas replacement by some neutral amino acids and L-ornithine decreased it.	Arginine	19-29	gap junction protein alpha 8	Homo sapiens	40-43
7380846-7	1980	The amino acid composition of H1t differs significantly from that of somatic type H1 variants (for example, higher arginine and methionine content).	Arginine	115-123	H1.6 linker histone, cluster member	Rattus norvegicus	30-33
7225193-2	1980	Two arginine derivatives that were developed as thrombin inhibitors (TI-189 and TI-233) selectively inhibited the 5-hydroxytryptamine (5-HT)-induced contraction of rabbit aortic strips in a competitive manner.	Arginine	4-12	prothrombin	Oryctolagus cuniculus	48-56
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Arginine	124-127	cuticle collagen 13	Bos taurus	265-276
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Arginine	132-135	cuticle collagen 13	Bos taurus	265-276
39929-3	1979	Both enzymes catalyzed the transfer of phosphate from ATP to calf thymus histone H2B, as well as to two synthetic peptides, Arg-Lys-Arg-Ser32-Arg-Lys-Glu and Arg-Lys-Glu-Ser36-Tyr-Ser-Val, corresponding to the amino acid sequences around serine 32 and serine 36 in histone H2B.	Arginine	132-135	cuticle collagen 13	Bos taurus	265-276
219013-1	1979	The inhibition by somatostatin (SRIF) of basal and arginine-stimulated glucagon, insulin, and glucose levels was compared with that obtained when SRIF was preceded by alpha-adrenergic blockade with phentolamine.	Arginine	51-59	somatostatin	Homo sapiens	18-30
430251-8	1979	Tumor ornithine decarboxylase activities were significantly reduced by dietary arginine supplementation.	Arginine	79-87	ornithine decarboxylase, structural 1	Mus musculus	6-29
103513-4	1979	The results demonstrate that both transplant procedures result in functioning beta and alpha cells that rapidly secrete both insulin and glucagon in response to arginine stimulation.	Arginine	161-169	insulin	Canis lupus familiaris	125-132
759249-6	1979	Biphasic release of glucagon, somatostatin, and pancreatic polypeptide was evoked by 10 mM arginine, the responses first being apparent within less than 30 s. Exogenous insulin (50 mU/ml) infused for 10 min had no statistically significant effect on glucagon, somatostatin, or pancreatic polypeptide secretion.	Arginine	91-99	insulin	Canis lupus familiaris	169-176
422323-1	1979	An analog of sheep insulin which differs from the parent molecule in that the C-terminal amino acid residue of the A chain, asparagine, is replaced by arginine, has been synthesized and isolated in highly purified form.	Arginine	151-159	LOC105613195	Ovis aries	19-26
363491-2	1978	Three weeks after jejunal or ileal resection, when the dogs might still have been in a catabolic state, insulin and pancreatic glucagon release in response to intravenously infused glucose and arginine was reduced.	Arginine	193-201	insulin	Canis lupus familiaris	104-111
696875-6	1978	The guanidino carbon of arginine was incorporated by the kidney into urea, creatine GSA, GAA, and guanidinobutyric acid.	Arginine	24-32	alpha glucosidase	Rattus norvegicus	89-92
700282-0	1978	Somatotrophic diabetes: insulin release responses to arginine and glucagon in dogs.	Arginine	53-61	insulin	Canis lupus familiaris	24-31
656436-0	1978	An essential arginine residue in human prostatic acid phosphatase.	Arginine	13-21	acid phosphatase 3	Homo sapiens	39-65
656436-1	1978	Treatment of human prostatic acid phosphatase (orthophosphoric-monoester phosphohydrolase (acid optimum), EC 3.1.3.2) with either of the arginine-specific modifiers 2,3-butanedione or 1,2-cyclohexanedione in borate buffer at pH 8.1 leads to loss of activity.	Arginine	137-145	acid phosphatase 3	Homo sapiens	19-45
642927-1	1978	Complementation between arg-7 mutants defective in argininosuccinate lyase.	Arginine	24-27	argininosuccinate lyase	Homo sapiens	51-74
642927-2	1978	In Chlamydomonas reinhardi, the arg-7 cistron is the structural gene for the enzyme argininosuccinate lyase which catalyzes the last reaction in the biosynthesis of arginine.	Arginine	165-173	argininosuccinate lyase	Homo sapiens	84-107
619998-1	1978	A series of monocarboxylic and dicarboxylic acid sulfur-containing by-product analogues of lysine and arginine has been synthesized and tested as competitive inhibitors of bovine carboxypeptidase B.	Arginine	102-110	carboxypeptidase B1	Bos taurus	179-197
870515-7	1977	Somatostatin abolished IRI and GH responses to arginine in both groups studied (P less than 0.001).	Arginine	47-55	somatostatin	Homo sapiens	0-12
870353-4	1977	Somatostatin, at three different dosages, markedly influenced these patterns: HGH response to arginine was suppressed by the lowest somatostatin dose; IRG response was progressively inhibited by increasing doses of somatostatin but never reached zero; cortisol level was not decreased but slightly increased by somatostatin.	Arginine	94-102	somatostatin	Homo sapiens	0-12
870353-4	1977	Somatostatin, at three different dosages, markedly influenced these patterns: HGH response to arginine was suppressed by the lowest somatostatin dose; IRG response was progressively inhibited by increasing doses of somatostatin but never reached zero; cortisol level was not decreased but slightly increased by somatostatin.	Arginine	94-102	somatostatin	Homo sapiens	132-144
870353-5	1977	Substrate responses to arginine were also modified by somatostatin: alanine disappearance was impaired, this effect being dose-related; plasma FFA and 3-hydroxybutyrate concentrations showed a significant increase rather than decrease, consistent with somatostatin suppression of residual insulin secretion.	Arginine	23-31	somatostatin	Homo sapiens	54-66
870353-5	1977	Substrate responses to arginine were also modified by somatostatin: alanine disappearance was impaired, this effect being dose-related; plasma FFA and 3-hydroxybutyrate concentrations showed a significant increase rather than decrease, consistent with somatostatin suppression of residual insulin secretion.	Arginine	23-31	somatostatin	Homo sapiens	252-264
1002704-7	1976	Thus, specific removal with carboxypeptidase B of Arg-141 (alpha), which is close to Val-1 (alpha) in deoxyhemoglobin, abolishes the enhancement in carbamylation.	Arginine	50-53	carboxypeptidase B1	Homo sapiens	28-46
6489-8	1976	CFI preparations readily hydrolyzed the peptide Arg-Phe-Ala.	Arginine	48-51	complement factor I	Homo sapiens	0-3
944186-10	1976	Results of peptide maps, the amino acid composition of tryptic peptides, and the sequences of two small tryptic peptides suggest that porcine neurophysin III contains the entire molecule of porcine neurophysin I plus a tripeptide -Arg-Arg-Ala connected the COOH terminus.	Arginine	231-234	oxytocin/neurophysin I prepropeptide	Homo sapiens	142-155
944186-10	1976	Results of peptide maps, the amino acid composition of tryptic peptides, and the sequences of two small tryptic peptides suggest that porcine neurophysin III contains the entire molecule of porcine neurophysin I plus a tripeptide -Arg-Arg-Ala connected the COOH terminus.	Arginine	235-238	oxytocin/neurophysin I prepropeptide	Homo sapiens	142-155
1691-3	1975	Exposure of mixtures of beta1 and beta3NGF dimers to 8 M urea to produce monomers, followed by removal of urea to allow recombination, resulted in the formation of the hybrid beta2NGF, comprising one arginine-containing and one arginine-less chain, as well as the parent dimers.	Arginine	200-208	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	24-29
1691-3	1975	Exposure of mixtures of beta1 and beta3NGF dimers to 8 M urea to produce monomers, followed by removal of urea to allow recombination, resulted in the formation of the hybrid beta2NGF, comprising one arginine-containing and one arginine-less chain, as well as the parent dimers.	Arginine	228-236	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	24-29
1225574-0	1975	Hemoglobin Castilla beta 32 (B14) Leu leads to Arg; a new unstable variant producing severe hemolytic disease.	Arginine	47-50	NADH:ubiquinone oxidoreductase subunit A6	Homo sapiens	0-32
1158861-14	1975	When fluorescence titrations were used to monitor the ability of cytoplasmic malate dehydrogenase to form a binary complex with NADH and to form a ternary complex with NADH and hydroxymalonate, only the formation of ternary complex seemed to be effected by arginine modification.	Arginine	257-265	malic enzyme 1	Homo sapiens	77-97
4362772-1	1974	The effects of an arginine-utilizing mycoplasma, Mycoplasma arginini, and of varying levels of arginine in the growth media of the Epstein-Barr virus (EBV)-containing EB1 and EB3 cell lines, and the EBV-free RPMI 1788 cell line, were studied.	Arginine	18-26	microtubule associated protein RP/EB family member 1	Homo sapiens	167-170
4362772-1	1974	The effects of an arginine-utilizing mycoplasma, Mycoplasma arginini, and of varying levels of arginine in the growth media of the Epstein-Barr virus (EBV)-containing EB1 and EB3 cell lines, and the EBV-free RPMI 1788 cell line, were studied.	Arginine	95-103	microtubule associated protein RP/EB family member 1	Homo sapiens	167-170
4362772-2	1974	l-Arginine, at a concentration of 0.1 mM in the growth medium, led to a reduction of the EBV capsid antigen content of the EB1 and EB3 cells lines as determined by indirect immunofluorescence, and M. arginini infection enhanced this reduction.	Arginine	0-10	microtubule associated protein RP/EB family member 1	Homo sapiens	123-126
4362772-5	1974	The addition of arginine to a final concentration of 0.6 mM in the growth medium caused a dual effect: the EB1 and EB3 cell lines maintained the original level of EBV capsid antigens, even when infected with M. arginini; immune product synthesis was greatly reduced or completely inhibited by the addition of arginine, and M. arginini infection caused no further reduction of immune product synthesis.	Arginine	16-24	microtubule associated protein RP/EB family member 1	Homo sapiens	107-110
4362772-5	1974	The addition of arginine to a final concentration of 0.6 mM in the growth medium caused a dual effect: the EB1 and EB3 cell lines maintained the original level of EBV capsid antigens, even when infected with M. arginini; immune product synthesis was greatly reduced or completely inhibited by the addition of arginine, and M. arginini infection caused no further reduction of immune product synthesis.	Arginine	309-317	microtubule associated protein RP/EB family member 1	Homo sapiens	107-110
4808885-0	1974	Stimulation of insulin and glucagon release in the dog by a nonmetabolizable arginine analog.	Arginine	77-85	insulin	Canis lupus familiaris	15-22
24419545-5	1974	As well as lysine, the content of other amino acids, such as aspartic acid, arginine, glycine, threonine, valine and histidine are also, in general, increased by the presence of the o 2 gene in recessive homozygous condition.The results obtained have shown that a number of correlation coefficients between the protein quality traits and yield components related to kernel characteristics are negative and significant, especially in the presence of the o 2 gene in recessive homozygous condition.	Arginine	76-84	regulatory protein opaque-2	Zea mays	182-185
4748512-0	1973	Hemoglobin Okaloosa (beta 48 (CD7) leucine leads to arginine).	Arginine	52-60	CD7 molecule	Homo sapiens	30-33
4748512-5	1973	Amino acid analysis indicated that leucine at position beta48 (CD7) had been replaced by arginine.	Arginine	89-97	CD7 molecule	Homo sapiens	63-66
33977387-6	2021	Methionine, glutamic acid, and arginine showed significantly higher concentrations in GP-C, whereas proline and tryptophan showed higher concentrations in the GP-B group (p < 0.017).	Arginine	31-39	glycophorin C (Gerbich blood group)	Homo sapiens	86-90
33893743-4	2021	This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan.	Arginine	166-174	CD4 molecule	Macaca mulatta	114-117
33893743-4	2021	This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan.	Arginine	166-174	CD4 molecule	Macaca mulatta	196-199
33999432-5	2021	PRMT1 methylates several arginine residues in the C-terminal nuclear/nucleolar localization sequence (NLS/NoLS) of p14ARF .	Arginine	25-33	protein arginine methyltransferase 1	Homo sapiens	0-5
33999432-10	2021	Our data reveal that PRMT1-mediated arginine methylation is an important trigger for p14ARF "s stress-induced tumor-suppressive function.	Arginine	36-44	protein arginine methyltransferase 1	Homo sapiens	21-26
33465368-11	2021	miR103a-3p promoted demethylation of an arginine residue of GATA3 by down-regulating protein arginine methyltransferase 5 (PRMT5) mRNA.	Arginine	40-48	GATA binding protein 3	Homo sapiens	60-65
34034233-10	2021	Furthermore, this influx is necessary for PAD2 nuclear translocation and resulting citrullination of histone H3 arginine residues 2, 8, and 17.	Arginine	112-120	peptidyl arginine deiminase 2	Homo sapiens	42-46
33485722-1	2021	Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins.	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
33893278-8	2021	Given the strong correlation of TEAD4 expression and prostate carcinogenesis, targeting TEAD4 may be beneficially used to enhance arginine-deprivation therapy and prostate cancer therapy.	Arginine	130-138	TEA domain transcription factor 4	Homo sapiens	88-93
33857456-12	2021	CKD/diabetes comparison: ARG abundance patterns in cirrhosis are distinguishable on machine learning and include more gram-positive ARGs.	Arginine	25-28	serpin family A member 2 (gene/pseudogene)	Homo sapiens	132-136
33924051-4	2021	We found that a heterozygous tnnt2a mutation deleting Arginine at position 94 and Lysine at position 95 of TnT causes progressive cardiac structural changes resulting in heart failure.	Arginine	54-62	troponin T type 2a (cardiac)	Danio rerio	29-35
33513288-1	2021	Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates arginine residues of histone H3 and non-histone proteins.	Arginine	8-16	coactivator associated arginine methyltransferase 1	Homo sapiens	41-46
33918349-5	2021	Here, we identified a loss-of-function mutant of AtARP4 with a single nucleotide change from glycine to arginine, which had significantly smaller leaf size.	Arginine	104-112	actin-related protein 4	Arabidopsis thaliana	49-55
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	47-58
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	60-63
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	89-92
33795008-3	2021	Recently, a genetic knockin FTD-GRN mouse model was generated bearing this GrnR493X mutation, at the analogous arginine in murine Grn.	Arginine	111-119	granulin	Mus musculus	32-35
33795008-3	2021	Recently, a genetic knockin FTD-GRN mouse model was generated bearing this GrnR493X mutation, at the analogous arginine in murine Grn.	Arginine	111-119	granulin	Mus musculus	75-78
33743287-8	2021	l-arginine pretreatment reduces AGEs generation and accumulation by regulating STAB1 and RAGE gene expression levels.	Arginine	0-10	stabilin 1	Homo sapiens	79-84
33743287-8	2021	l-arginine pretreatment reduces AGEs generation and accumulation by regulating STAB1 and RAGE gene expression levels.	Arginine	0-10	advanced glycosylation end-product specific receptor	Homo sapiens	89-93
33743287-12	2021	CONCLUSIONS: An early l-arginine treatment is able to prevent oxidative stress and AGEs accumulation caused by overfeeding in human endothelial cell line by regulating STAB1/RAGE gene expression and by reducing excess arginase activity.	Arginine	22-32	stabilin 1	Homo sapiens	168-173
33743287-12	2021	CONCLUSIONS: An early l-arginine treatment is able to prevent oxidative stress and AGEs accumulation caused by overfeeding in human endothelial cell line by regulating STAB1/RAGE gene expression and by reducing excess arginase activity.	Arginine	22-32	advanced glycosylation end-product specific receptor	Homo sapiens	174-178
33841424-0	2021	Flagellin From Pseudomonas Aeruginosa Stimulates ATB0,+ Transporter for Arginine and Neutral Amino Acids in Human Airway Epithelial Cells.	Arginine	72-80	solute carrier family 1 member 5	Homo sapiens	49-53
33720684-5	2021	Then, the conjugated GOx can utilize O2 production to catalyze intracellular glucose to generate H2O2, which not only starves the tumor cells but also promotes oxidation of l-Arg to NO.	Arginine	173-178	hydroxyacid oxidase 1	Homo sapiens	21-24
33657325-7	2021	This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD).	Arginine	160-163	vitronectin	Homo sapiens	187-196
33667543-6	2021	By mutating the methylated arginine residue, R81, and by silencing expression of protein arginine methyltransferase 1 (PRMT1), we show that PRMT1 catalyzes R81 methylation of Smad6 upon BMP treatment; R81 methylation subsequently facilitates Smad6 interaction with the phosphorylated active Smad1; and R81 methylation facilitates Smad6-mediated interruption of Smad1/Smad4 complex formation and nuclear translocation.	Arginine	27-35	protein arginine methyltransferase 1	Homo sapiens	140-145
33529484-4	2021	Molecular docking and molecular dynamics simulations suggest that interactions with Glu 39, Glu 78, Arg 111, Pro 137, Asp 251 and His 252 are an important factor for inhibitors affinity toward the DNase I.	Arginine	100-103	deoxyribonuclease 1	Homo sapiens	197-204
33645546-3	2021	explored NO deficiency using human cell and mouse models that lacked argininosuccinate lyase (ASL), the enzyme involved in synthesizing arginine and NO production.	Arginine	136-144	argininosuccinate lyase	Mus musculus	69-92
33645546-3	2021	explored NO deficiency using human cell and mouse models that lacked argininosuccinate lyase (ASL), the enzyme involved in synthesizing arginine and NO production.	Arginine	136-144	argininosuccinate lyase	Mus musculus	94-97
33645546-6	2021	These experiments suggest that ASL regulates arginine synthesis in osteoblasts, which leads to enhanced NO production and increased glucose metabolism.	Arginine	45-53	argininosuccinate lyase	Mus musculus	31-34
33609317-9	2021	RESULTS: Dapagliflozin and/or L-arginine induced a significant increment of the survival rate, tissue total nitrate/nitrite, paraoxonase-1, caspase 3, beclin-1 and JNK activities, significant lowering of the tumor volume, tissue TGF-beta1, and IL-1alpha expression alongside an improvement of the histopathologic findings, versus the SEC group.	Arginine	30-40	mitogen-activated protein kinase 8	Mus musculus	164-167
33680983-5	2020	However, arginase is another enzyme, which if expressed concomitantly, may strongly compete for L-Arginine, and suppress NO production by iNOS.	Arginine	96-106	arginase	Leishmania donovani	9-17
33574402-3	2021	Enzymatic activity of mammalian NAGS doubles in the presence of L-arginine, but the physiological significance of NAGS activation by L-arginine has been unknown.	Arginine	64-74	N-acetylglutamate synthase	Homo sapiens	32-36
33574402-3	2021	Enzymatic activity of mammalian NAGS doubles in the presence of L-arginine, but the physiological significance of NAGS activation by L-arginine has been unknown.	Arginine	133-143	N-acetylglutamate synthase	Homo sapiens	32-36
33574402-3	2021	Enzymatic activity of mammalian NAGS doubles in the presence of L-arginine, but the physiological significance of NAGS activation by L-arginine has been unknown.	Arginine	133-143	N-acetylglutamate synthase	Homo sapiens	114-118
33574402-8	2021	The corresponding mutation in human NAGS (NP_694551.1:p.E360D) that abolishes binding and activation by L-arginine was identified in a patient with NAGS deficiency.	Arginine	104-114	N-acetylglutamate synthase	Homo sapiens	36-40
33574402-9	2021	Our results show that NAGS deficiency can be rescued by gene therapy, and suggest that L-arginine binding to the NAGS enzyme is essential for normal ureagenesis.	Arginine	87-97	N-acetylglutamate synthase	Homo sapiens	22-26
33289903-5	2021	Docking studies followed by protein-ligand interaction fingerprint (PLIF) analysis using the AOX enzyme and the mutated analogues revealed the importance of the residues Leu 122, Arg 118 and Thr 219 within the hydrophobic cavity.	Arginine	179-182	acyl-CoA oxidase 1	Homo sapiens	93-96
33445063-6	2021	Finally, hippocampal protein arginine methyltransferase 1 (PRMT1) and PRMT8 are enhanced in the presence of PAME to suggest a possible pathway of methylated fatty acids to modulate arginine-based enzymatic methylation.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	59-64
33468684-7	2021	In contrast, the leucine/pantothenate/arginine auxotroph H37Rv DeltaleuCD DeltapanCD DeltaargB was eliminated in both immunocompetent and immunodeficient Rag1-/- mice.	Arginine	38-46	recombination activating 1	Mus musculus	154-158
33419170-6	2021	In contrast, the genes that maintain mitochondrial functions and neuronal survival, including Hba-a2 and Hbb-b2, were significantly increased in mice that ingested Arg.	Arginine	164-167	hemoglobin, beta adult minor chain	Mus musculus	105-111
33551103-6	2021	Pesticide-exposed agricultural workers carrying variant XPF Gln/Gln (AA) genotype showed higher comet tail length (p < 0.01) than wild type Arg/Arg (GG) genotype.	Arginine	140-143	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	56-59
33551103-6	2021	Pesticide-exposed agricultural workers carrying variant XPF Gln/Gln (AA) genotype showed higher comet tail length (p < 0.01) than wild type Arg/Arg (GG) genotype.	Arginine	144-147	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	56-59
33210935-10	2020	Renal Nox4 mRNA activity was approximately 2.1 fold higher (P<0.05) in the L-arginine treated rats but was normalized by apocynin and apocynin plus catalase treatment.	Arginine	75-85	NADPH oxidase 4	Rattus norvegicus	6-10
33284012-10	2020	The ARG binding density of only 18F-GEH200449 was consistent with known MAO-B expression in the human brain.	Arginine	4-7	monoamine oxidase B	Homo sapiens	72-77
33325825-0	2020	Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.	Arginine	51-59	TSC complex subunit 2	Homo sapiens	23-27
33293536-0	2020	Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.	Arginine	7-15	coactivator associated arginine methyltransferase 1	Homo sapiens	31-36
33231598-4	2020	After the chemical modification of arginine, an increased inhibition by polyP, at a 1 : 1 molar ratio (polyP : RBP), is measured already at 0.1 mug mL-1.	Arginine	35-43	retinol binding protein 4	Homo sapiens	111-114
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	arginase type II	Mus musculus	168-172
32721946-7	2020	The pro-resolving effect of Arg1-deletion was reduced by an L-arginine-free diet, but rescued by simultaneous deletion of other L-arginine-metabolizing enzymes such as Arg2 or Nos2, demonstrating that protection from colitis requires L-arginine.	Arginine	128-138	arginase type II	Mus musculus	168-172
33122522-0	2020	Inhibition of CHRM3 Alleviates Necrosis Via the MAPK-p38/miR-31-5p/RIP3 Axis in L-Arginine-Induced Severe Acute Pancreatitis.	Arginine	80-90	receptor-interacting serine-threonine kinase 3	Mus musculus	67-71
33122522-8	2020	CONCLUSIONS: Necrosis in L-arginine-induced SAP is promoted by CHRM3 through the mitogen-activated protein kinase-p38/miR-31-5p/RIP3 axis.	Arginine	25-35	receptor-interacting serine-threonine kinase 3	Mus musculus	128-132
33028909-11	2020	Taken together, our data in this study demonstrated that L-arginine-eNOS-NO pathway is important for rat hind limb development during late embryonic stage.	Arginine	57-67	nitric oxide synthase 3	Rattus norvegicus	68-72
32815282-5	2020	Through exome sequencing of a child with developmental delay, hypotonia, and spasticity, we found a novel de novo insertion mutation of three nucleotides in the STXBP1 coding region, resulting in an additional arginine after position 39 (R39dup).	Arginine	210-218	syntaxin binding protein 1	Homo sapiens	161-167
32901087-0	2020	L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic beta-cells.	Arginine	0-10	glucokinase	Homo sapiens	56-67
32901087-2	2020	Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine.	Arginine	146-156	glucokinase	Homo sapiens	0-11
32901087-2	2020	Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine.	Arginine	146-156	glucokinase	Homo sapiens	13-16
32901087-2	2020	Glucokinase (GCK), the key regulator of GSIS and a disease-causing gene of maturity-onset diabetes of the young type 2 (MODY2), was found to bind L-arginine.	Arginine	146-156	glucokinase	Homo sapiens	120-125
32901087-4	2020	We analyzed glucokinase mutants and identified three glutamate residues that mediate binding to L-arginine.	Arginine	96-106	glucokinase	Homo sapiens	12-23
32901087-5	2020	One MODY2 patient with GCKE442* demonstrated lower C-peptide-to-glucose ratio after arginine administration.	Arginine	84-92	glucokinase	Homo sapiens	4-9
32901087-7	2020	In addition, we elucidated that the binding of arginine protects glucokinase from degradation by E3 ubiquitin ligase cereblon mediated ubiquitination.	Arginine	47-55	glucokinase	Homo sapiens	65-76
32901087-8	2020	We conclude that L-arginine induces insulin secretion by increasing G6P production by glucokinase through direct stimulation and by prevention of degradation.	Arginine	17-27	glucokinase	Homo sapiens	86-97
32447347-5	2020	Noticeably, asymmetric demethylation of histone H4 at arginine 3 (H4R3me2as), catalyzed by PRMT1, was decreased prior to histone H4.	Arginine	54-62	protein arginine methyltransferase 1	Homo sapiens	91-96
32451822-2	2020	In human ACTN3, a nonsense mutation at codon 577 that encodes arginine (R) produces the R577X polymorphism.	Arginine	62-70	actinin alpha 3	Homo sapiens	9-14
32506441-10	2020	Stat2-/- mice were protected from caerulein- and L-arginine-induced pancreatitis.	Arginine	49-59	signal transducer and activator of transcription 2	Mus musculus	0-5
32739205-3	2020	Arginase 2 (ARG2) competes with nitric oxide synthase for the same substrate, L-arginine, and is implicated in the regulation of reactive nitrogen species.	Arginine	78-88	arginase type II	Mus musculus	0-10
32739205-3	2020	Arginase 2 (ARG2) competes with nitric oxide synthase for the same substrate, L-arginine, and is implicated in the regulation of reactive nitrogen species.	Arginine	78-88	arginase type II	Mus musculus	12-16
32859041-0	2020	Fine-Tuning of GLI Activity through Arginine Methylation: Its Mechanisms and Function.	Arginine	36-44	GLI family zinc finger 1	Homo sapiens	15-18
32982727-2	2020	Based on the fact that Ang-(1-7) acts through release of nitric oxide (NO), a new peptide, A-1317 was engineered adding the amino acid L-Arginine, the NO precursor, to the N-terminal portion of the Ang-(1-7).	Arginine	135-145	angiogenin	Rattus norvegicus	23-31
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	protein arginine methyltransferase 1	Homo sapiens	84-120
32583741-4	2020	Here, we report that the gamma2-COP-binding site of SCYL1 is arginine-methylated by protein arginine methyltransferase 1 (PRMT1), and that SCYL1 arginine methylation is important for the interaction of SCYL1 with gamma2-COP.	Arginine	61-69	protein arginine methyltransferase 1	Homo sapiens	122-127
32583741-8	2020	Thus, PRMT1 regulates Golgi morphogenesis via SCYL1 arginine methylation.	Arginine	52-60	protein arginine methyltransferase 1	Homo sapiens	6-11
32583741-9	2020	We propose that SCYL1 arginine methylation by PRMT1 contributes to axon and dendrite morphogenesis in neurons.	Arginine	22-30	protein arginine methyltransferase 1	Homo sapiens	46-51
32783662-6	2020	CONCLUSIONS: L-arginine-induced acute pancreatitis modulates TNF-alpha-AMPK axis, IL-10 and other AP biomarkers, which is protected by vitamin E; thus, may offer therapeutic potential in humans.	Arginine	13-23	interleukin 10	Homo sapiens	82-87
32157382-13	2020	Previous work has unveiled that the Arg-N-end rule degradation pathway (Arg-N-degron pathway) mediates the degradation of PINK1, and thus fine-tune PINK1-dependent mitochondrial quality control pathway.	Arginine	36-39	PTEN induced kinase 1	Homo sapiens	122-127
32157382-13	2020	Previous work has unveiled that the Arg-N-end rule degradation pathway (Arg-N-degron pathway) mediates the degradation of PINK1, and thus fine-tune PINK1-dependent mitochondrial quality control pathway.	Arginine	36-39	PTEN induced kinase 1	Homo sapiens	148-153
32157382-13	2020	Previous work has unveiled that the Arg-N-end rule degradation pathway (Arg-N-degron pathway) mediates the degradation of PINK1, and thus fine-tune PINK1-dependent mitochondrial quality control pathway.	Arginine	72-75	PTEN induced kinase 1	Homo sapiens	122-127
32157382-13	2020	Previous work has unveiled that the Arg-N-end rule degradation pathway (Arg-N-degron pathway) mediates the degradation of PINK1, and thus fine-tune PINK1-dependent mitochondrial quality control pathway.	Arginine	72-75	PTEN induced kinase 1	Homo sapiens	148-153
32725957-5	2020	Moreover, enhanced the expression of Wnt3a in Paneth cells, which is a ligand of the Wnt/beta-catenin signaling pathway, mediates the effects of L-arginine on ISCs function.	Arginine	145-155	catenin (cadherin associated protein), beta 1	Mus musculus	89-101
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	35-43	arginine permease CAN1	Saccharomyces cerevisiae S288C	61-65
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	35-43	arginine permease ALP1	Saccharomyces cerevisiae S288C	67-71
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	arginine permease ALP1	Saccharomyces cerevisiae S288C	67-71
32169766-4	2020	We found that BLE had influence on arginine transport (GAP1, CAN1, ALP1, and VBA2 gene) in Saccharomyces cerevisiae (S. cerevisiae), which significantly up-regulated arginine uptake gene expression in vacuole (VBA2 gene) so that inhibited arginine metabolism.	Arginine	166-174	arginine permease ALP1	Saccharomyces cerevisiae S288C	67-71
32461319-10	2020	Computational models and an RNA immunoprecipitation assay revealed arginine-rich domains of NS3 to be crucial for pre-miRNA binding and degradation of host miRNAs.	Arginine	67-75	KRAS proto-oncogene, GTPase	Homo sapiens	92-95
32461319-18	2020	Second, arginine molecules on NS3 were the main miRNA-binding sites, because we demonstrated that miRNA degradation was abolished if arginines at R226 and R202 were mutated.	Arginine	8-16	KRAS proto-oncogene, GTPase	Homo sapiens	30-33
32461319-18	2020	Second, arginine molecules on NS3 were the main miRNA-binding sites, because we demonstrated that miRNA degradation was abolished if arginines at R226 and R202 were mutated.	Arginine	133-142	KRAS proto-oncogene, GTPase	Homo sapiens	30-33
32661950-9	2020	The growth hormone cDNA sequence of Assaf sheep has a unique three single nucleotide polymorphisms (SNPs) (A637A638G639) that encodes for arginine (Arg194); this insertion mutation (AAG) was not found in the growth hormone cDNA sequences of Boer goat in the present study and GenBank database breeds.	Arginine	138-146	somatotropin	Ovis aries	4-18
32661950-9	2020	The growth hormone cDNA sequence of Assaf sheep has a unique three single nucleotide polymorphisms (SNPs) (A637A638G639) that encodes for arginine (Arg194); this insertion mutation (AAG) was not found in the growth hormone cDNA sequences of Boer goat in the present study and GenBank database breeds.	Arginine	138-146	somatotropin	Ovis aries	208-222
32353589-4	2020	By virtual docking and site-directed mutagenesis analysis, we confirmed that serine 190 and arginine 235 of HNF4alpha are both essential for GA to exert its antagonistic action on HNF4alpha.	Arginine	92-100	hepatic nuclear factor 4, alpha	Mus musculus	108-117
32353589-4	2020	By virtual docking and site-directed mutagenesis analysis, we confirmed that serine 190 and arginine 235 of HNF4alpha are both essential for GA to exert its antagonistic action on HNF4alpha.	Arginine	92-100	hepatic nuclear factor 4, alpha	Mus musculus	180-189
32423812-0	2020	UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.	Arginine	60-68	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	0-5
32423812-0	2020	UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.	Arginine	60-68	insulin II	Mus musculus	14-24
32423812-2	2020	(1) Using affinity magnetic nanobeads technology, we identified that proinsulin is retained in the endoplasmic reticulum (ER) through UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) when arginine availability is limited.	Arginine	194-202	insulin II	Mus musculus	69-79
32423812-2	2020	(1) Using affinity magnetic nanobeads technology, we identified that proinsulin is retained in the endoplasmic reticulum (ER) through UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) when arginine availability is limited.	Arginine	194-202	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	182-187
32423812-4	2020	The ability of arginine to release proinsulin from UGGT1 closely correlates with arginine-induced insulin secretion in several models of beta cells indicating that UGGT1-proinsulin interaction regulates arginine-induced insulin secretion.	Arginine	15-23	insulin II	Mus musculus	35-45
32572095-4	2020	Here, we demonstrate that matriptase directly interacts with APLP1 and that APLP1 is cleaved in cellulo by matriptase in its E1 ectodomains at arginine 124.	Arginine	143-151	amyloid beta precursor like protein 1	Homo sapiens	76-81
32512924-8	2020	Interestingly, the L-Arg/ADMA ratio varied across MTHFR genotypes (p <= 0.0001) and was lower in subgroups carrying the most impaired enzyme with respect to patients carrying the conservative MTHFR (p <= 0.0001, p <= 0.05, respectively).	Arginine	19-24	methylenetetrahydrofolate reductase	Homo sapiens	50-55
32512924-8	2020	Interestingly, the L-Arg/ADMA ratio varied across MTHFR genotypes (p <= 0.0001) and was lower in subgroups carrying the most impaired enzyme with respect to patients carrying the conservative MTHFR (p <= 0.0001, p <= 0.05, respectively).	Arginine	19-24	methylenetetrahydrofolate reductase	Homo sapiens	192-197
32512924-10	2020	Conclusions: A low L-Arg/ADMA ratio correlates with impaired activity of MTHFR and with the jeopardized IAS phenotype along a severity spectrum encompassing OS, PFO with long/tight tunnel, PFO with short/large tunnel, and SI.	Arginine	19-24	methylenetetrahydrofolate reductase	Homo sapiens	73-78
32582237-7	2020	We further show that suppression of ARG by nitrate is mediated by the nitrate transporter/sensor NRT1.1.	Arginine	36-39	nitrate transporter 1.1	Arabidopsis thaliana	97-103
32923127-1	2020	One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2).	Arginine	93-101	arginase 2	Homo sapiens	119-129
32923127-1	2020	One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2).	Arginine	93-101	arginase 2	Homo sapiens	131-135
32457299-0	2020	Author Correction: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.	Arginine	61-69	protein arginine methyltransferase 7	Homo sapiens	49-54
32409666-0	2020	Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.	Arginine	42-50	protein arginine methyltransferase 7	Homo sapiens	30-35
32409666-4	2020	Inhibition or knockout of cellular PRMT7 results in drastically reduced levels of arginine monomethylated HSP70 family stress-associated proteins.	Arginine	82-90	protein arginine methyltransferase 7	Homo sapiens	35-40
32409666-4	2020	Inhibition or knockout of cellular PRMT7 results in drastically reduced levels of arginine monomethylated HSP70 family stress-associated proteins.	Arginine	82-90	heat shock protein family A (Hsp70) member 4	Homo sapiens	106-111
32380753-11	2020	The in vivo study showed that arginine infusion promoted milk protein content, casein yield and the expression of CSN1S1 and CSN1S2.	Arginine	30-38	alpha-S2-casein	Bos taurus	125-131
32334587-4	2020	RESULTS: In this study, several engineering approaches formerly used for the low-affinity glucose transporters in Saccharomyces cerevisiae, were successfully applied for earlier identified transporter Hxt1 in Ogataea polymorpha to improve xylose consumption (engineering involved asparagine substitution to alanine at position 358 and replacement of N-terminal lysine residues predicted to be the target of ubiquitination for arginine residues).	Arginine	426-434	hexose transporter HXT1	Saccharomyces cerevisiae S288C	201-205
32302572-3	2020	We show that, under non-stress conditions, G3BP adopts a compact auto-inhibited state stabilized by electrostatic intramolecular interactions between the intrinsically disordered acidic tracts and the positively charged arginine-rich region.	Arginine	220-228	G3BP stress granule assembly factor 1	Homo sapiens	43-47
32944613-0	2020	Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	13-18
32944613-1	2020	We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	52-90
32944613-1	2020	We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	92-97
32719266-9	2020	Conclusions: This study suggests that HNSCC patients with Gln substitution in place of Arg at position 399 (both homozygous and heterozygous) in XRCC1 protein have significantly inferior survival functions, higher recurrence rate, and events after radical treatment.	Arginine	87-90	X-ray repair cross complementing 1	Homo sapiens	145-150
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	87-90	melanocortin 3 receptor	Mus musculus	55-59
33062177-2	2020	The key binding and functional determinant of AGRP, an MC3R and MC4R antagonist, is an Arg-Phe-Phe tripeptide sequence located on an exposed hexapeptide (Arg-Phe-Phe-Asn-Ala-Phe) loop.	Arginine	154-157	melanocortin 3 receptor	Mus musculus	55-59
31884067-10	2020	CONCLUSIONS: Loss of arginine methylation leads to an increase in HNK-1 glycan in the developing cerebellum but not in the cerebral cortex via upregulation of the biosynthetic enzyme and carrier glycoproteins.	Arginine	21-29	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	66-71
32092898-2	2020	ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein.	Arginine	11-19	ADP-ribosylarginine hydrolase	Homo sapiens	33-37
32092898-2	2020	ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein.	Arginine	80-88	ADP-ribosylarginine hydrolase	Homo sapiens	0-31
32092898-2	2020	ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein.	Arginine	80-88	ADP-ribosylarginine hydrolase	Homo sapiens	33-37
32092898-8	2020	In the myocardium, in response to cellular injury, an arginine-specific mono-ADP-ribosylation cycle, involving ART1 and ARH1, regulated the level and cellular distribution of ADP-ribosylated tripartite motif-containing protein 72 (TRIM72).	Arginine	54-62	ADP-ribosylarginine hydrolase	Homo sapiens	120-124
32092898-8	2020	In the myocardium, in response to cellular injury, an arginine-specific mono-ADP-ribosylation cycle, involving ART1 and ARH1, regulated the level and cellular distribution of ADP-ribosylated tripartite motif-containing protein 72 (TRIM72).	Arginine	54-62	tripartite motif containing 72	Homo sapiens	231-237
32092898-9	2020	Confirmed substrates of ARH1 in vivo are Galphas and TRIM72, however, more than a thousand proteins, ADP-ribosylated on arginine, have been identified by proteomic analysis.	Arginine	120-128	ADP-ribosylarginine hydrolase	Homo sapiens	24-28
32079300-0	2020	Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.	Arginine	9-17	peptidyl arginine deiminase 2	Homo sapiens	31-36
31732298-4	2020	Moreover, miR24-2 inhibits the di-/tri-methylation of histone H4 arginine 3 by reducing PRMT7 and then promotes the expression of Nanog via long noncoding RNA HULC.	Arginine	65-73	protein arginine methyltransferase 7	Homo sapiens	88-93
30660686-2	2020	Human foetoplacental microvascular and macrovascular endothelium from GDM pregnancy show increased maximal l-arginine transport capacity via the human cationic amino acid transporter 1 (hCAT-1) isoform and nitric oxide (NO) synthesis by the endothelial NO synthase (eNOS).	Arginine	107-117	solute carrier family 7 member 1	Homo sapiens	186-192
31520395-1	2020	BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is the founding member of the PRMT family of proteins, whose members catalyze methylation of arginine residues in various proteins.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	50-55
31348608-3	2020	The lysine-arginine-ornithine binding protein (LAO) is a PBP of 238 residues that binds the basic amino acids l-arginine and l-histidine with nm and mum affinity, respectively.	Arginine	110-120	phosphatidylethanolamine binding protein 1	Homo sapiens	57-60
31870966-8	2020	The supplement of l-arginine to KO rats partly alleviated neurological damages accompanied with higher expression of HIF-1alpha.	Arginine	18-28	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	117-127
31991880-5	2020	mRNA expression of the creatine synthesizing enzymes arginine:glycine aminotransferase (GATM) and guanidinoacetate methyltransferase (GAMT), the creatine transporter (SLC6A8), and the creatine kinases (mitochondrial CKMT1A & cytosolic BBCK) was assessed.	Arginine	53-61	glycine amidinotransferase	Homo sapiens	88-92
32240815-3	2020	Recent preclinical studies suggest that the multi-tyrosine kinase inhibitor, imatinib, which targets the Abl kinases c-Abl and Arg, has the potential to restore endothelial dysfunction caused by inflammatory agonists.	Arginine	127-130	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-108
32240815-7	2020	In addition, direct activation of Abl family kinases with the small molecule activator DPH resulted in endothelial barrier disruption that was attenuated by Arg siRNA.	Arginine	157-160	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-37
31822692-7	2019	Moreover, we show that, despite only a few non-synonymous mutations specifically targeting arginine residues, SRGAP2C is unique compared to SRGAP2B in its ability to induce long-lasting changes in synaptic density throughout adulthood.	Arginine	91-99	SLIT-ROBO Rho GTPase activating protein 2C	Homo sapiens	110-117
31666677-7	2019	Furthermore, deactivation of the methyltransferase Hmt1 constitutes a molecular switch that regulates Psp2 arginine methylation status as well as its mRNA binding activity in response to starvation.	Arginine	107-115	regenerating family member 1 beta	Homo sapiens	102-106
31679457-0	2019	A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity.	Arginine	12-20	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	62-67
31679457-6	2019	Here, we describe an arginine/lysine-based motif ([R/K](S)[R/K][R/K]) in the proximal C-terminus regulating the endoplasmic reticulum (ER) export of KCNE1 and KCNE2 in HEK293 cells.	Arginine	21-29	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	149-154
31496325-9	2019	Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT.	Arginine	11-14	interleukin 17F	Rattus norvegicus	122-128
31496325-10	2019	In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet.	Arginine	50-53	interleukin 17F	Rattus norvegicus	318-324
31558604-8	2019	We propose that IGF-1 Glu-58 interacts with IGF-1R Arg-704 and belongs to IGF-1 site 1, a finding supported by the NMR structure of the less active Asp-58-IGF-1 variant.	Arginine	51-54	insulin like growth factor 1 receptor	Homo sapiens	44-50
31442759-10	2019	Moreover, the potential ARG hosts and the co-occurrence of ARGs and intI1 were revealed by network analysis.	Arginine	24-27	serpin family A member 2 (gene/pseudogene)	Homo sapiens	59-63
30723942-5	2019	Over the last decade, novel discoveries enabled by the generation of new transgenic argininosuccinate lyase (ASL)-deficient mouse models have been achieved, such as, a better understanding of ASL and its close interaction with nitric oxide metabolism, ASL physiological role outside the liver, and the pathophysiological role of oxidative/nitrosative stress or excessive arginine treatment.	Arginine	371-379	argininosuccinate lyase	Mus musculus	84-107
30723942-5	2019	Over the last decade, novel discoveries enabled by the generation of new transgenic argininosuccinate lyase (ASL)-deficient mouse models have been achieved, such as, a better understanding of ASL and its close interaction with nitric oxide metabolism, ASL physiological role outside the liver, and the pathophysiological role of oxidative/nitrosative stress or excessive arginine treatment.	Arginine	371-379	argininosuccinate lyase	Mus musculus	109-112
30723942-5	2019	Over the last decade, novel discoveries enabled by the generation of new transgenic argininosuccinate lyase (ASL)-deficient mouse models have been achieved, such as, a better understanding of ASL and its close interaction with nitric oxide metabolism, ASL physiological role outside the liver, and the pathophysiological role of oxidative/nitrosative stress or excessive arginine treatment.	Arginine	371-379	argininosuccinate lyase	Mus musculus	192-195
30723942-5	2019	Over the last decade, novel discoveries enabled by the generation of new transgenic argininosuccinate lyase (ASL)-deficient mouse models have been achieved, such as, a better understanding of ASL and its close interaction with nitric oxide metabolism, ASL physiological role outside the liver, and the pathophysiological role of oxidative/nitrosative stress or excessive arginine treatment.	Arginine	371-379	argininosuccinate lyase	Mus musculus	192-195
31531954-4	2019	In this study, an affibody molecule against HER3 is conjugated to a biomimetic peptide RALA (an amphipathic and cationic peptide enriched with arginine) and the ability of the fusion vector for targeting HER3 and afterward delivering specific genes in breast cancer cells is evaluated.	Arginine	143-151	RAS like proto-oncogene A	Homo sapiens	87-91
31395602-5	2019	Mechanistically, we reveal that PRMT1 methylates FLT3 at arginine (R) residues 972 and 973, and its oncogenic function in MLL-r ALL cells is FLT3 methylation-dependent.	Arginine	57-65	protein arginine methyltransferase 1	Homo sapiens	32-37
31395602-10	2019	These results indicate that abolishing FLT3 arginine methylation through PRMT1 inhibition represents a promising strategy to target MLL-r ALL cells.	Arginine	44-52	protein arginine methyltransferase 1	Homo sapiens	73-78
31306580-3	2019	Herein, we have identified a linear peptide RWrNK, containing an unnatural d-arginine (r), as the integrin alphavbeta3-specific ligand.	Arginine	2-3	integrin subunit alpha V	Homo sapiens	98-118
31406120-4	2019	Using a calcium-imaging assay and two-voltage clamp recording, we found that one of the honey bee"s gustatory receptors, AmGr10, functions as a broadly tuned amino acid receptor responding to glutamate, aspartate, asparagine, arginine, lysine, and glutamine, but not to other sweet or bitter compounds.	Arginine	226-234	gustatory receptor 10	Apis mellifera	121-127
31217189-0	2019	PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	0-5
31217189-7	2019	Mechanistically, PRMT1 catalyzed FLT3-ITD protein methylation at arginine 972/973, and PRMT1 promoted leukemia cell growth in an FLT3 methylation-dependent manner.	Arginine	65-73	FMS-like tyrosine kinase 3	Mus musculus	33-37
31217189-7	2019	Mechanistically, PRMT1 catalyzed FLT3-ITD protein methylation at arginine 972/973, and PRMT1 promoted leukemia cell growth in an FLT3 methylation-dependent manner.	Arginine	65-73	FMS-like tyrosine kinase 3	Mus musculus	129-133
31375551-5	2019	now show that Mmp10, an RS enzyme implicated in the methylation of Arg-285 in methyl coenzyme M reductase, binds a methylcobalamin cofactor required for methyl transfer from SAM to a peptide substrate.	Arginine	67-70	matrix metallopeptidase 10	Homo sapiens	14-19
31121497-5	2019	This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein.	Arginine	45-53	interleukin 12b	Mus musculus	144-153
31121497-5	2019	This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein.	Arginine	55-56	interleukin 12b	Mus musculus	144-153
31067316-6	2019	Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B.	Arginine	250-253	metastasis associated 1	Homo sapiens	153-157
31067316-6	2019	Equilibrium binding studies and molecular dynamics simulations show that the p.R3S substitution disrupts ionic coordination between BCL11B and the RBBP4-MTA1 complex, a subassembly of the NuRD complex, and increases the conformational flexibility of Arg-4, Lys-5 and Gln-6 of BCL11B.	Arginine	250-253	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	257-262
31369573-6	2019	Interestingly, the prevalence of FGFR3 mutation was higher in patients with the Arg allele, whereas that of the RAS mutation was higher in patients without the Arg allele.	Arginine	80-83	fibroblast growth factor receptor 3	Homo sapiens	33-38
31369573-8	2019	In NMIBC, FGFR1 expression was higher in patients without the Arg allele and FGFR3 expression was higher in patients with the Arg allele.	Arginine	126-129	fibroblast growth factor receptor 3	Homo sapiens	77-82
30916320-9	2019	Together, these findings demonstrate that there is a degree of redundancy between the PRMT5 and PRMT1 pathways, even though these two enzymes deposit different types of arginine methylation marks.	Arginine	169-177	protein arginine methyltransferase 1	Homo sapiens	96-101
31015257-2	2019	Recently, an arginine to proline substitution (R1673P) in the S4 voltage-sensing helix of the fourth membrane-bound repeat of CaV2.1 was linked to a severe neurological disorder characterized by generalized hypotonia, ataxia, cerebellar atrophy, and global developmental delay.	Arginine	13-21	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	126-132
30653406-7	2019	In the absence of PRMT1, increased PRMT6 specifically methylates FOXO3 at arginine 188 and 249, leading to its activation.	Arginine	74-82	forkhead box O3	Mus musculus	65-70
31015230-6	2019	C/EBPalpha associated with and was methylated by PRMT1 at three arginine residues (R35, R156, and R165).	Arginine	64-72	protein arginine methyltransferase 1	Homo sapiens	49-54
31160916-8	2019	Results: The distinct metabolites between PDR and NDR groups were significantly enriched in 9 KEGG pathways (P &lt; 0.05, impact &gt; 0.1), namely, alanine, aspartate and glutamate metabolism, caffeine metabolism, beta-alanine metabolism, purine metabolism, cysteine and methionine metabolism, sulfur metabolism, sphingosine metabolism, and arginine and proline metabolism.	Arginine	341-349	serine/threonine kinase 38	Homo sapiens	50-53
31043582-0	2019	PRMT1 regulates the tumour-initiating properties of esophageal squamous cell carcinoma through histone H4 arginine methylation coupled with transcriptional activation.	Arginine	106-114	protein arginine methyltransferase 1	Homo sapiens	0-5
31043582-10	2019	Together, our studies highlight that PRMT1 activates and maintains esophageal TICs by mediating transcription alteration through histone H4 arginine methylation.	Arginine	140-148	protein arginine methyltransferase 1	Homo sapiens	37-42
30772011-0	2019	The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.	Arginine	65-73	troponin I3, cardiac type	Homo sapiens	26-42
30772011-0	2019	The inhibitory subunit of cardiac troponin (cTnI) is modified by arginine methylation in the human heart.	Arginine	65-73	troponin I3, cardiac type	Homo sapiens	44-48
30772011-4	2019	METHODS AND RESULTS: Here we report, for the first time, that cTnI is modified by arginine methylation in human myocardium.	Arginine	82-90	troponin I3, cardiac type	Homo sapiens	62-66
30842273-4	2019	IRF3 is phosphorylated by c-Abl and c-Abl-related kinase, Arg, mainly at Y292.	Arginine	58-61	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	26-31
30842273-4	2019	IRF3 is phosphorylated by c-Abl and c-Abl-related kinase, Arg, mainly at Y292.	Arginine	58-61	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	36-41
30987202-5	2019	Here, we report the design and investigation of a new hTS variant, in which Gln62, located at the dimer interface, has been replaced by arginine in order to destabilize the enzyme quaternary assembly.	Arginine	136-144	APC down-regulated 1	Homo sapiens	54-57
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Arginine	206-209	relaxin family peptide/INSL5 receptor 4	Homo sapiens	174-179
30684458-7	2019	Based on binding complementation of mutant ligands towards mutant receptors, we deduced possible electrostatic interactions of the agonist and antagonist with both RXFP3 and RXFP4: their B-chain C-terminal Arg residue interacts with the deeply buried Glu residue in the WxxExxxD motif of both receptors, and one or two of their B-chain central Arg residues interact with the shallowly buried Asp residue in the WxxExxxD motif of both receptors.	Arginine	344-347	relaxin family peptide/INSL5 receptor 4	Homo sapiens	174-179
30798662-0	2019	Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.	Arginine	32-40	FMS-like tyrosine kinase 1	Mus musculus	113-118
30798662-0	2019	Profound Decrease in Glomerular Arginine Transport by CAT (Cationic Amino Acid Transporter)-1 Contributes to the FLT-1 (FMS-Like Tyrosine Kinase 1) Induced Preeclampsia in the Pregnant Mice.	Arginine	32-40	FMS-like tyrosine kinase 1	Mus musculus	120-146
30798662-5	2019	L-arginine prevented the increase in blood pressure and albuminuria in Flt-1 pregnant but not in Flt-1 virgin mice.	Arginine	0-10	FMS-like tyrosine kinase 1	Mus musculus	71-76
30798662-6	2019	Flt-1 augmented arginine transport in pregnant but not in virgin dames.	Arginine	16-24	FMS-like tyrosine kinase 1	Mus musculus	0-5
30798662-7	2019	Ex vivo inhibition of CAT-2 leaving exclusively CAT-1 activity, decreased arginine transport velocities in Flt-1 animals more prominently in pregnant dames.	Arginine	74-82	dominant cataract 2	Mus musculus	22-27
30798662-7	2019	Ex vivo inhibition of CAT-2 leaving exclusively CAT-1 activity, decreased arginine transport velocities in Flt-1 animals more prominently in pregnant dames.	Arginine	74-82	FMS-like tyrosine kinase 1	Mus musculus	107-112
30798662-10	2019	L-arginine augmented arginine transport in pregnant and Flt-pregnant mice and prevented the increase in pCAT-1 and CAT-2 expression.	Arginine	0-10	dominant cataract 2	Mus musculus	115-120
30798662-10	2019	L-arginine augmented arginine transport in pregnant and Flt-pregnant mice and prevented the increase in pCAT-1 and CAT-2 expression.	Arginine	2-10	dominant cataract 2	Mus musculus	115-120
30798662-12	2019	L-arginine abolished the decrease in cGMP levels only in Flt-1-pregnant mice.	Arginine	0-10	FMS-like tyrosine kinase 1	Mus musculus	57-62
30914922-7	2019	Here we report a novel missense mutation (chrX:62875607C&gt;T, p.R356Q) in ARHGEF9 that affects one of the two paired arginine residues in the PH domain that were predicted to be vital for binding phosphoinositides.	Arginine	118-126	Cdc42 guanine nucleotide exchange factor 9	Homo sapiens	75-82
30823936-10	2019	GroPIns4P directly binds to the Shp1-SH2 domain region (with the crucial residues being Ser 118, Arg 138 and Ser 140) and thereby promotes the association between Shp1 and Src, and the dephosphorylation of the Src-inhibitory phosphotyrosine in position 530, resulting in Src activation.	Arginine	97-100	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	32-36
30006058-1	2019	PRMT7 encodes for an arginine methyltransferase that methylates arginine residues on various protein substrates and has been shown to play a role in various developmental processes.	Arginine	21-29	protein arginine methyltransferase 7	Homo sapiens	0-5
30760564-5	2019	RBM48 is coselected with the U12 splicing factor, zinc finger CCCH-type, RNA binding motif, and Ser/Arg rich 2/Rough endosperm 3 (RGH3).	Arginine	100-103	RNA binding motif protein 48	Homo sapiens	0-5
30808864-14	2019	Silencing of ARG2 re-sensitized the H520 xenografts to PEGylated ARG1 treatment, partially mediated through arginine depletion via G1 arrest and apoptosis.	Arginine	108-116	arginase 2	Homo sapiens	13-17
31069134-6	2019	The modification of arginine to citrulline enhanced binding of the peptides to HLA-DP4 and induced high-frequency CD4 responses in HLA-DP4 transgenic mouse models.	Arginine	20-28	CD4 antigen	Mus musculus	114-117
30679275-2	2019	Our recent work uncovered a requirement for cytoplasmic arginine methylation during Wnt signaling through the activity of protein arginine methyltransferase 1 (PRMT1), which transfers one-carbon groups from SAM to many protein substrates.	Arginine	56-64	protein arginine methyltransferase 1	Homo sapiens	122-158
30679275-2	2019	Our recent work uncovered a requirement for cytoplasmic arginine methylation during Wnt signaling through the activity of protein arginine methyltransferase 1 (PRMT1), which transfers one-carbon groups from SAM to many protein substrates.	Arginine	56-64	protein arginine methyltransferase 1	Homo sapiens	160-165
30736843-4	2019	PRMT5 and PRMT1, which are important members of the PRMT family, catalyze the transfer of methyl groups to the arginine of substrate proteins.	Arginine	111-119	protein arginine methyltransferase 1	Homo sapiens	10-15
30736843-5	2019	PRMT5 can monomethylate or symmetrically dimethylate arginine residues, while PRMT1 can monomethylate or asymmetrically dimethylate arginine residues.	Arginine	132-140	protein arginine methyltransferase 1	Homo sapiens	78-83
30545920-2	2019	We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism.	Arginine	101-109	arginase 2	Homo sapiens	25-35
30545920-2	2019	We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism.	Arginine	101-109	arginase 2	Homo sapiens	37-41
30318155-4	2019	FOXP3 undergoes methylation on arginine residues at positions 48 and 51 by interacting with protein arginine methyltransferase 1 (PRMT1).	Arginine	31-39	protein arginine methyltransferase 1	Homo sapiens	92-128
30318155-4	2019	FOXP3 undergoes methylation on arginine residues at positions 48 and 51 by interacting with protein arginine methyltransferase 1 (PRMT1).	Arginine	31-39	protein arginine methyltransferase 1	Homo sapiens	130-135
30365037-4	2019	Among the amino acids tested, arginine concentration was significantly increased in wild-type mice compared to ERAP1-knockout mice.	Arginine	30-38	endoplasmic reticulum aminopeptidase 1	Mus musculus	111-116
30682707-4	2019	Here, we found arginines 484 and 516 (R484/R516) of SKN-1 were asymmetrically dimethylated by PRMT-1.	Arginine	15-24	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	94-100
30728809-4	2019	Using molecular dynamics simulations, we demonstrate that ABBA binds to the "central cavity" in the elbow of vWbp by interacting with Arg-70, His-71, Ala-72, Gly-73, Tyr-74, Glu-75, Tyr-83, and Gln-87 in vWbp, thus interfering with the binding of vWbp to prothrombin.	Arginine	134-137	MTSS I-BAR domain containing 2	Mus musculus	58-62
30503338-0	2019	Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states.	Arginine	22-30	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	38-45
30503338-0	2019	Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states.	Arginine	49-57	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	38-45
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	0-8	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	66-73
30503338-3	2019	Arginine can stimulate mTORC1 activity by releasing the inhibitor CASTOR1 (Cellular Arginine Sensor of mTORC1) from GATOR2, a positive regulator of mTORC1 which interacts with GATOR1, the GAP for RagA/B.	Arginine	84-92	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	66-73
30503338-4	2019	Three groups have resolved the structures of arginine-CASTOR1 complex, shedding a new light on molecular basis of the regulation of mTORC1 activity by arginine.	Arginine	45-53	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	54-61
30503338-4	2019	Three groups have resolved the structures of arginine-CASTOR1 complex, shedding a new light on molecular basis of the regulation of mTORC1 activity by arginine.	Arginine	151-159	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	54-61
30503338-6	2019	Here, we report crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states at 2.05 A and 2.8 A, respectively.	Arginine	38-46	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	54-61
30503338-6	2019	Here, we report crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states at 2.05 A and 2.8 A, respectively.	Arginine	65-73	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	54-61
30503338-9	2019	Therefore, we conclude a detailed structural interpretation of arginine sensing by CASTOR1 in mTORC1 pathway.	Arginine	63-71	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	83-90
30191588-7	2019	Furthermore, bioinformatics analysis revealed that arginine (Arg) to tryptophan (Trp) substitution at rs2278426 position causes structural instability of ANGPTL8 protein.	Arginine	51-59	angiopoietin like 8	Homo sapiens	154-161
29924583-3	2018	Herein, stereochemical modifications of the Arg-Phe-Phe sequence were examined in the octapeptide AGRP-derived macrocyclic scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was Asn or diaminopropionic acid (Dap).	Arginine	44-47	agouti related neuropeptide	Homo sapiens	98-102
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	agouti related neuropeptide	Homo sapiens	68-72
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 4 receptor	Homo sapiens	147-151
29924583-5	2018	While l-to-d inversions of the Arg-Phe-Phe sequence in a 20-residue AGRP-derived ligand previously resulted in agonist activity at the MC1R, MC3R, MC4R, and MC5R, only the MC1R was consistently stimulated by the macrocyclic ligands in the present study, with varying ligand potencies and efficacies observed at the MC1R.	Arginine	31-34	melanocortin 5 receptor	Homo sapiens	157-161
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Arginine	134-137	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	57-61
30129165-8	2018	The results indicated that the primary variances between SHP2-WT and SHP2-E76K were the different interactions between Glu/Lys 76 and Arg 265, Tyr 80 and Leu 77, Leu 77 and Tyr 81, Thr 73 and Glu 258, Ala 75 and Cys 259, Phe 71 and Tyr 81, Ala 75 and Glu 258, and Tyr 73 and Glu/Lys 76.	Arginine	134-137	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	69-73
30341185-6	2018	We find that this invariant Arg residue switches conformation to allow peptides to hang out of the groove of BF2*1201, suggesting that this phenomenon is common in chickens and other nonmammalian vertebrates, perhaps allowing the single dominantly expressed class I molecule to bind a larger repertoire of peptides.	Arginine	28-31	Major histocompatibility complex class I antigen BF2	Gallus gallus	109-112
30295033-0	2018	Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.	Arginine	38-41	angiotensin I converting enzyme 2	Rattus norvegicus	66-97
30295033-2	2018	Our previous studies indicated that egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) could upregulate ACE2 mRNA level in mesenteric artery of spontaneously hypertensive rats (SHRs), suggesting the potential of IRW as an in vivo ACE2 activator.	Arginine	88-91	angiotensin I converting enzyme 2	Rattus norvegicus	114-118
30295033-2	2018	Our previous studies indicated that egg white-derived antihypertensive peptide IRW (Ile-Arg-Trp) could upregulate ACE2 mRNA level in mesenteric artery of spontaneously hypertensive rats (SHRs), suggesting the potential of IRW as an in vivo ACE2 activator.	Arginine	88-91	angiotensin I converting enzyme 2	Rattus norvegicus	240-244
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	21-24	solute carrier family 30 member 4	Homo sapiens	163-167
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	21-24	solute carrier family 30 member 7	Homo sapiens	172-176
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	25-28	solute carrier family 30 member 4	Homo sapiens	163-167
30142362-5	2018	Moreover, PBMCs from Arg/Arg T2DM subjects showed increased intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7.	Arginine	25-28	solute carrier family 30 member 7	Homo sapiens	172-176
30142362-6	2018	Higher release of IL-1alpha, IL-1beta, IFN-gamma, IL-12p70 and TNF-alpha and a reduced IL-10 secretion after lipopolysaccharide (LPS) stimulation were observed in PBMCs from Arg/Arg T2DM carriers as compared to subjects with the Trp variant.	Arginine	174-177	interleukin 10	Homo sapiens	87-92
31039948-6	2018	Expression of Bax, Fas and p53 mRNA was increased (P&lt;0.05) in RES compared with CON ewes, but were reduced (P&gt;0.05) in both RES+ARG and RES+NCG ewes.	Arginine	134-137	apoptosis regulator BAX	Ovis aries	14-17
30456387-5	2018	Functional binding to the methyltransferase PRMT1 was promoted by continual arginine stretches, whereas interaction with the methyl-binding protein SMN1 was arginine content-dependent irrespective of linear position within the unstructured region.	Arginine	76-84	protein arginine methyltransferase 1	Homo sapiens	44-49
30181260-3	2018	The Ragulator complex tethers the Rag heterodimer to the lysosomal surface, and the SLC38A9 transmembrane protein is a lysosomal arginine sensor that upon activation stimulates mTORC1 activity through the Rag GTPases.	Arginine	129-137	solute carrier family 38 member 9	Homo sapiens	84-91
30181260-7	2018	Upon arginine binding, SLC38A9 converts RagA from the GDP- to the GTP-loaded state, and therefore activates the Rag GTPase heterodimer.	Arginine	5-13	solute carrier family 38 member 9	Homo sapiens	23-30
29787824-1	2018	The human SR-related CTD associated factor 1 (SCAF1) gene is a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, which has been discovered and cloned by members of our lab.	Arginine	95-98	SR-related CTD associated factor 1	Homo sapiens	10-44
29787824-1	2018	The human SR-related CTD associated factor 1 (SCAF1) gene is a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors, which has been discovered and cloned by members of our lab.	Arginine	95-98	SR-related CTD associated factor 1	Homo sapiens	46-51
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	glutathione peroxidase 1	Homo sapiens	127-151
30175262-9	2018	Moreover, compared with the DT group, the DT + Arg and DT + NCG groups enhanced mRNA expression of superoxide dismutase (SOD), glutathione peroxidase 1 (GPx1), glutathione reductase (GR), nuclear factor erythroid 2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1(Keap-1), and mammalian target of rapamycin (mTOR) (P &lt; 0.05).	Arginine	47-50	glutathione peroxidase 1	Homo sapiens	153-157
29947909-10	2018	L-NAME (arginine-based competitive eNOS inhibitor) enhanced the eNOS expression (not activity) whereas wortmannin reduced the brain eNOS levels in EGA- and STZ-ICV-treated rats.	Arginine	8-16	nitric oxide synthase 3	Rattus norvegicus	35-39
29947909-10	2018	L-NAME (arginine-based competitive eNOS inhibitor) enhanced the eNOS expression (not activity) whereas wortmannin reduced the brain eNOS levels in EGA- and STZ-ICV-treated rats.	Arginine	8-16	nitric oxide synthase 3	Rattus norvegicus	64-68
29947909-10	2018	L-NAME (arginine-based competitive eNOS inhibitor) enhanced the eNOS expression (not activity) whereas wortmannin reduced the brain eNOS levels in EGA- and STZ-ICV-treated rats.	Arginine	8-16	nitric oxide synthase 3	Rattus norvegicus	64-68
29983399-12	2018	In contrast, PVN nNOS inhibition blocked/attenuated these effects in addition to significantly increase in resting MAP and HR (with larger effects in T and l-arginine treated rats vs. respective controls,  P &lt; 0.05).	Arginine	156-166	nitric oxide synthase 1	Rattus norvegicus	17-21
29907569-0	2018	Arginine methylation of SMAD7 by PRMT1 in TGF-beta-induced epithelial-mesenchymal transition and epithelial stem-cell generation.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	33-38
29857001-2	2018	A nonsense mutation of the arginine (R) at the codon for amino acid 577 of the ACTN3 gene generates a premature termination codon (PTC) and produces the R577X polymorphism in humans (X specifies translational termination).	Arginine	27-35	actinin alpha 3	Homo sapiens	79-84
30036999-0	2018	The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8.	Arginine	16-24	crystallin alpha B	Homo sapiens	124-129
30036999-4	2018	Substitution of this arginine with an alanine induced changes in thermal stability and/or intrinsic fluorescence of the related HspB1 and HspB8, but yielded only modest changes in the same biophysical properties of HspB4, HspB5, and HspB6 which together belong to another clade of vertebrate sHsps.	Arginine	21-29	crystallin alpha B	Homo sapiens	222-227
30036999-5	2018	Removal of the positively charged Arg side chain resulted in destabilization of the large oligomers of HspB1 and formation of smaller size oligomers of HspB5.	Arginine	34-37	crystallin alpha B	Homo sapiens	152-157
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Arginine	136-139	integrin subunit beta 1	Homo sapiens	76-90
29356040-8	2018	This signal transduction was initiated by competitive binding of CD147 with integrin beta1 that interrupted the interaction between the Arg-Gly-Asp motif of fibronectin and integrin beta1.	Arginine	136-139	integrin subunit beta 1	Homo sapiens	173-187
29744943-0	2018	The floral homeotic protein SEPALLATA3 recognizes target DNA sequences by shape readout involving a conserved arginine residue in the MADS-domain.	Arginine	110-118	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	28-38
29744943-8	2018	Analysis of mutant SEPALLATA3 proteins further revealed that a highly conserved arginine residue, which is expected to contact the DNA minor groove, contributes significantly to the shape readout.	Arginine	80-88	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	19-29
29718323-4	2018	TDP1 arginine methylation also increases XRCC1 association with TDP1 in response to CPT, and the recruitment of XRCC1 to Top1cc DNA damage foci.	Arginine	5-13	X-ray repair cross complementing 1	Homo sapiens	41-46
29685976-5	2018	Crystal structures showed that compound 4 binds to the PRMT4 active site, displacing strongly the S-adenosyl-l-methionine cofactor, occupying its binding site, and interacting with the arginine substrate site through the cytosine moiety that probes the space filled by a substrate peptide methylation intermediate.	Arginine	185-193	coactivator associated arginine methyltransferase 1	Homo sapiens	55-60
29657074-6	2018	Similarly, G35A, A49G and A64G transitions were identified in the PRM2 gene which resulted in altered amino acid sequences from arginine (R) to glutamine (Q), from arginine (R) to glycine (G) and from arginine (R) to glycine (G), respectively.	Arginine	128-136	protamine 2	Bos taurus	66-70
29657074-6	2018	Similarly, G35A, A49G and A64G transitions were identified in the PRM2 gene which resulted in altered amino acid sequences from arginine (R) to glutamine (Q), from arginine (R) to glycine (G) and from arginine (R) to glycine (G), respectively.	Arginine	164-172	protamine 2	Bos taurus	66-70
29657074-6	2018	Similarly, G35A, A49G and A64G transitions were identified in the PRM2 gene which resulted in altered amino acid sequences from arginine (R) to glutamine (Q), from arginine (R) to glycine (G) and from arginine (R) to glycine (G), respectively.	Arginine	164-172	protamine 2	Bos taurus	66-70
29878271-1	2018	Background: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production.	Arginine	136-144	argininosuccinate lyase	Mus musculus	83-106
29626090-1	2018	In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt signaling that stimulates nuclear factor of activated T cells (viz NFATc4).	Arginine	89-97	low density lipoprotein receptor-related protein 6	Mus musculus	67-71
29626090-1	2018	In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt signaling that stimulates nuclear factor of activated T cells (viz NFATc4).	Arginine	99-102	low density lipoprotein receptor-related protein 6	Mus musculus	67-71
29626090-3	2018	LRP6-dependent Arg methylation was regulated on &gt;500 proteins; only 21 exhibited increased monomethylation (MMA) with concomitant reductions in dimethylation.	Arginine	15-18	low density lipoprotein receptor-related protein 6	Mus musculus	0-4
29768197-2	2018	Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by nitric oxide synthase (NOS) isoforms.	Arginine	65-73	argininosuccinate lyase	Mus musculus	0-23
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	coactivator associated arginine methyltransferase 1	Homo sapiens	32-37
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	paired box 7	Homo sapiens	56-60
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	ASH2 like, histone lysine methyltransferase complex subunit	Homo sapiens	107-112
29681515-2	2018	This activation is dependent on Carm1, which methylates Pax7 on multiple arginine residues, to recruit the ASH2L:MLL1/2:WDR5:RBBP5 histone methyltransferase complex to the proximal promoter of Myf5.	Arginine	73-81	myogenic factor 5	Homo sapiens	193-197
29577948-4	2018	After 14 days feeding, the mRNA levels and protein expressions of Keap1 and Cul3 were gradually reduced by increasing l-arginine intake, resulting that the nuclear factor Nrf2 was activated.	Arginine	118-128	Kelch-like ECH-associated protein 1	Rattus norvegicus	66-71
29577948-6	2018	The present study demonstrates that the supplementation of l-arginine stimulates GSH synthesis and activates Nrf2 pathway, leading to the up-regulation of ARE-driven antioxidant expressions via Nrf2-Keap1 pathway.	Arginine	59-69	Kelch-like ECH-associated protein 1	Rattus norvegicus	199-204
29361115-1	2018	Protein arginine methyltransferase 1 (PRMT1) catalyzes asymmetric arginine dimethylation of cellular proteins and thus modulates various biological processes, including gene regulation, RNA metabolism, cell signaling and DNA repair.	Arginine	8-16	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	38-43
29361115-2	2018	Since prmt-1 null mutant completely abolishes asymmetric dimethylarginine in C. elegans, PRMT-1 is thought to play a crucial role in determining levels of asymmetric arginine dimethylation.	Arginine	65-73	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	6-12
29361115-6	2018	Nevertheless, surprisingly arginine methylation levels are increased when elt-2 is silenced, implying that erythroid-like transcription factor (ELT)-2 may also have ability to inhibit methyltransferase activity of PRMT-1.	Arginine	27-35	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	214-220
29361115-8	2018	Furthermore, we find that ELT-2 interferes with PRMT-1-induced arginine methylation in a dose-dependent manner.	Arginine	63-71	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	48-54
29361115-9	2018	Collectively, our results illustrate the two modes of PRMT-1 regulation, which could determine the levels of asymmetric arginine dimethylation in C. elegans.	Arginine	120-128	Protein arginine N-methyltransferase 1	Caenorhabditis elegans	54-60
29742735-9	2018	A heterozygous mutation (c.844C&gt;T), located in exon 6 of TINF2 gene, that changed arginine to cysteine (Arg282Cys) was identified in this proband by whole exome sequencing.	Arginine	85-93	TERF1 interacting nuclear factor 2	Homo sapiens	60-65
29121483-9	2018	ARG treatment decreased Kiss1 and increased ERalpha mRNA abundance.	Arginine	0-3	KiSS-1 metastasis-suppressor	Mus musculus	24-29
29854093-5	2018	L-NAME, an NOS inhibitor, decreased NO concentrations within cells and abolished the stimulatory effect of L-Arg on protein synthesis and the phosphorylation of mTOR and p70S6K.	Arginine	107-112	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	170-176
29854093-7	2018	Blocking mTOR with rapamycin abolished the stimulatory effect of both L-Arg and SNP on protein synthesis and p70S6K phosphorylation.	Arginine	70-75	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	109-115
29854093-8	2018	These results indicate that L-Arg stimulates protein synthesis via the activation of the mTOR (Thr 2446)/p70S6K signaling pathway in an NO-dependent manner.	Arginine	28-33	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	105-111
29689199-0	2018	Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl.	Arginine	0-8	protein arginine methyltransferase 2	Homo sapiens	24-29
29628309-4	2018	Unexpectedly, JMJD6 is necessary for MED12 to interact with CARM1, which methylates MED12 at multiple arginine sites and regulates its chromatin binding.	Arginine	102-110	coactivator associated arginine methyltransferase 1	Homo sapiens	60-65
29719619-4	2018	TP-064 inhibited the methyltransferase activity of PRMT4 with high potency (half-maximal inhibitory concentration, IC50 &lt; 10 nM) and selectivity over other PRMT family proteins, and reduced arginine dimethylation of the PRMT4 substrates BRG1-associated factor 155 (BAF155; IC50= 340 +- 30 nM) and Mediator complex subunit 12 (MED12; IC50 = 43 +- 10 nM).	Arginine	193-201	coactivator associated arginine methyltransferase 1	Homo sapiens	51-56
29409673-11	2018	Our data not only illustrate the important roles of OGG1 in histone modification, but also reveal the mechanism by which OGG1 affects PRMT5 binding on H4R3 resulting in the symmetrical dimethylation of histone H4 arginine-3.	Arginine	213-221	8-oxoguanine DNA-glycosylase 1	Mus musculus	121-125
29409673-11	2018	Our data not only illustrate the important roles of OGG1 in histone modification, but also reveal the mechanism by which OGG1 affects PRMT5 binding on H4R3 resulting in the symmetrical dimethylation of histone H4 arginine-3.	Arginine	213-221	LOC102641229	Mus musculus	202-212
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	lysine demethylase 8	Homo sapiens	62-67
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	lysine demethylase 8	Homo sapiens	113-118
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	RCC1 domain containing 1	Homo sapiens	208-272
29563586-3	2018	Here we report how extensive screening with peptides based on JMJD5 interacting proteins led to the finding that JMJD5 catalyses stereoselective C-3 hydroxylation of arginine residues in sequences from human regulator of chromosome condensation domain-containing protein 1 (RCCD1) and ribosomal protein S6 (RPS6).	Arginine	166-174	RCC1 domain containing 1	Homo sapiens	274-279
29398442-0	2018	Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer"s agents: Structure-activity relationship study of Arg-mimetic region.	Arginine	122-125	glutaminyl-peptide cyclotransferase	Homo sapiens	13-31
29289698-10	2018	Our conclusion is further supported by a positive correlation across brain regions between TyrRS expression and arginine-accelerated KTP production.	Arginine	112-120	tyrosyl-tRNA synthetase 1	Rattus norvegicus	91-96
29463776-8	2018	As an indication of clinical relevance, the abundance of mRNAs encoding Abl/Arg, Sp1, Ets1, and cathepsins was positively correlated in primary melanomas, and Abl/Arg-driven invasion in culture and metastasis in vivo required cathepsin secretion.	Arginine	163-166	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	159-162
29402293-3	2018	The +371 C allele results in an Arg/Thr mutation that abolishes the cytotoxic activity of the ECP protein.	Arginine	32-35	ribonuclease A family member 3	Homo sapiens	94-97
28044061-5	2018	Furthermore, we measured miR-495 expression in response to acute cocaine in mice and found that it is downregulated rapidly and selectively in the NAc, along with concomitant increases in ARG expression.	Arginine	188-191	microRNA 495	Mus musculus	25-32
28610454-8	2018	ADH1B Arg/Arg and Arg carriers showed significantly higher total body and subcutaneous fats but association was abolished after controlling for ethnicity.	Arginine	6-9	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
28610454-8	2018	ADH1B Arg/Arg and Arg carriers showed significantly higher total body and subcutaneous fats but association was abolished after controlling for ethnicity.	Arginine	10-13	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
28610454-8	2018	ADH1B Arg/Arg and Arg carriers showed significantly higher total body and subcutaneous fats but association was abolished after controlling for ethnicity.	Arginine	10-13	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
29391504-6	2018	Furthermore, the hAOC3 inhibitors semicarbazide and imidazole reduce the binding of wild type and Arg/Ala mutated Siglec-9 peptides to hAOC3.	Arginine	98-101	sialic acid binding Ig like lectin 9	Homo sapiens	114-122
29410783-4	2018	In the non-classical pathway, Arg is converted to agmatine (Agm) by arginine decarboxylase (ADC), and Agm is converted to putrescine by agmatinase (AGMAT).	Arginine	30-33	antizyme inhibitor 2	Ovis aries	68-90
29410783-4	2018	In the non-classical pathway, Arg is converted to agmatine (Agm) by arginine decarboxylase (ADC), and Agm is converted to putrescine by agmatinase (AGMAT).	Arginine	30-33	antizyme inhibitor 2	Ovis aries	92-95
29111421-0	2018	Substitution impact of highly conserved arginine residue at position 75 in GJB1 gene in association with X-linked Charcot-Marie-tooth disease: A computational study.	Arginine	40-48	gap junction protein beta 1	Homo sapiens	75-79
29111421-4	2018	The aim of this study is to computationally predict the potential impact of different single amino acid substitutions at position 75 of Cx32, from arginine (R) to proline (P), glutamine (Q) and tryptophan (W).	Arginine	147-155	gap junction protein beta 1	Homo sapiens	136-140
29283194-6	2018	When Arg-Gly-Asp-AAP (AAP-RGD) peptides are attached to surface bound CB[8]/MV2+ complexes, cells adhere and can be released upon irradiation.	Arginine	5-8	serpin family F member 2	Homo sapiens	17-20
29283194-6	2018	When Arg-Gly-Asp-AAP (AAP-RGD) peptides are attached to surface bound CB[8]/MV2+ complexes, cells adhere and can be released upon irradiation.	Arginine	5-8	serpin family F member 2	Homo sapiens	22-25
29269254-4	2018	Complex size and cell uptake studies demonstrated that the nona-arginine/bombesin delivery system was more efficient at condensing and delivering pDNA into PC-3 prostate cancer cells compared to the hexa-arginine/bombesin delivery system.	Arginine	64-72	gastrin releasing peptide	Homo sapiens	73-81
28643125-3	2018	Recently, it has been reported that arginine 198/200 in EGFR extracellular domain is methylated by PRMT1 and that the methylation confers resistance to EGFR monoclonal antibody cetuximab in colorectal cancer cells.	Arginine	36-44	protein arginine methyltransferase 1	Homo sapiens	99-104
29607903-6	2018	The number and optical activity of the arginine residues and the degree of modification with oligoarginines in the polymer backbone were listed as a factor that would influence IgA induction.	Arginine	39-47	immunoglobulin heavy constant alpha	Mus musculus	177-180
30064337-2	2018	The mRNAs encoding the ubiquitously expressed actin-crosslinking proteins Filamin A and Filamin B undergo RNA editing leading to a highly conserved glutamine to arginine exchange at the identical position in either protein.	Arginine	161-169	filamin, beta	Mus musculus	88-97
29025897-3	2017	A single nucleotide polymorphism (SNP) variant in human TRIB3, which results in a glutamine (Q) to arginine (R) missense mutation in a conserved motif at position 84, confers stronger Akt binding, resulting in reduced Akt phosphorylation, and is associated with a predisposition to Type 2 diabetes, cardiovascular disease, diabetic nephropathy, chronic kidney disease and leukemogenesis.	Arginine	99-107	tribbles pseudokinase 3	Homo sapiens	56-61
29025897-6	2017	Consistent with the functional conservation of this arginine in modulating Akt activity, mouse Trib3 R84 misexpressed in the fly fat body blocked dAkt phosphorylation with a strength similar to wild-type Trbl.	Arginine	52-60	tribbles pseudokinase 3	Mus musculus	95-100
28542722-5	2017	This variant is predicted to change the highly conserved strongly basic arginine at position 538 in the PAX7 binding domain of PAXBP1 to a neutral cysteine (p.Arg538Cys) residue.	Arginine	72-80	paired box 7	Homo sapiens	104-108
29415833-12	2017	The IL-6/IL-10 ratio showed a statistically significant increase in the placebo group after exercise compared to the l-arg group (P &lt; 0.05).	Arginine	117-122	interleukin 10	Homo sapiens	9-14
28386107-2	2017	As with ABL, translocations that fuse ARG to ETV6/TEL have been identified in patients with leukemia.	Arginine	38-41	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	8-11
29184031-6	2017	Analysis of the constitutively open Orai1 mutant channels revealed two fundamental gates that enabled Ca2+ influx: Arginine side chains were displaced so they no longer blocked the pore, and a chain of water molecules formed in the hydrophobic pore region.	Arginine	115-123	ORAI calcium release-activated calcium modulator 1	Homo sapiens	36-41
28833276-11	2017	Otherwise, Arg/His genotype (rs1229984) in ADH1B gene showed a protective effect against HD (aOR = 0.36; 95% CI: 0.14 to 0.90) and BD (aOR = 0.49; 95% CI: 0.21 to 0.95).	Arginine	11-14	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	43-48
28855257-4	2017	We found that HLA-C*06:02 predominantly presents nonamer peptides with dominant arginine anchors at the P2 and P7 positions and a preference for small hydrophobic residues at the C terminus (POmega).	Arginine	80-88	major histocompatibility complex, class I, C	Homo sapiens	14-19
28855257-6	2017	These structures revealed that HLA-C*06:02 possesses a deep peptide-binding groove comprising two electronegative B- and E-pockets that coincide with the preference for P2 and P7 arginine anchors.	Arginine	179-187	major histocompatibility complex, class I, C	Homo sapiens	31-36
29693039-3	2018	This activation requires protein methyltransferase 1-regulated arginine methylation of STAT1.	Arginine	63-71	signal transducer and activator of transcription 1	Homo sapiens	87-92
29693039-15	2018	Conclusions: We conclude that arginine methylation of STAT1 is suppressed by JMJD6.	Arginine	30-38	signal transducer and activator of transcription 1	Homo sapiens	54-59
28927791-1	2017	Protein arginine methyltransferase 1 (PRMT1) catalyses the methylation of substrate arginine by transferring the methyl group from SAM (S-adenosyl-l-methionine), which leads to the formation of S-adenosyl homocysteine (SAH) and methylated arginine.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
28927791-1	2017	Protein arginine methyltransferase 1 (PRMT1) catalyses the methylation of substrate arginine by transferring the methyl group from SAM (S-adenosyl-l-methionine), which leads to the formation of S-adenosyl homocysteine (SAH) and methylated arginine.	Arginine	84-92	protein arginine methyltransferase 1	Homo sapiens	0-36
28927791-1	2017	Protein arginine methyltransferase 1 (PRMT1) catalyses the methylation of substrate arginine by transferring the methyl group from SAM (S-adenosyl-l-methionine), which leads to the formation of S-adenosyl homocysteine (SAH) and methylated arginine.	Arginine	84-92	protein arginine methyltransferase 1	Homo sapiens	38-43
28814503-5	2017	Can1 mutants altered in the arginine-binding site or a cytosolic tripeptide sequence permanently expose the alpha-arrestin-targeted region so that Art1 activation via TORC1 is sufficient to trigger their endocytosis.	Arginine	28-36	arginine permease CAN1	Saccharomyces cerevisiae S288C	0-4
29026071-0	2017	Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	34-39
29026071-7	2017	Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.	Arginine	87-95	protein arginine methyltransferase 1	Homo sapiens	24-29
28409218-8	2017	We find that the Sec61 translocon mediates less efficient membrane insertion of Arg-containing TM helices compared with our computational and experimental bilayer-insertion results.	Arginine	80-83	SEC61 translocon subunit alpha 1	Homo sapiens	17-22
28059652-3	2017	METHODS The authors performed immunohistochemical analysis to detect both the PRR and isocitrate dehydrogenase 1 with mutations involving arginine 132 ( IDH1R132H) in paraffin sections of 31 gliomas.	Arginine	138-146	ATPase H+ transporting accessory protein 2	Homo sapiens	78-81
28754372-5	2017	Inhibition of neuronal nitric oxide synthase (nNOS) or blocking the S-nitrosylation reaction with N-ethylmaleimide abolished the inhibitory effects of l-arginine on NMDA receptor currents recorded from spinal dorsal horn neurons in sham control and nerve-injured rats.	Arginine	151-161	nitric oxide synthase 1	Rattus norvegicus	14-44
28754372-5	2017	Inhibition of neuronal nitric oxide synthase (nNOS) or blocking the S-nitrosylation reaction with N-ethylmaleimide abolished the inhibitory effects of l-arginine on NMDA receptor currents recorded from spinal dorsal horn neurons in sham control and nerve-injured rats.	Arginine	151-161	nitric oxide synthase 1	Rattus norvegicus	46-50
28754372-8	2017	Furthermore, knockdown of nNOS with siRNA abolished the inhibitory effects of l-arginine, but not SNAP, on spinal NMDA receptor activity in both groups of rats.	Arginine	78-88	nitric oxide synthase 1	Rattus norvegicus	26-30
28754372-9	2017	Additionally, intrathecal injection of l-arginine significantly attenuated mechanical or thermal hyperalgesia induced by nerve injury, and the l-arginine effect was diminished in rats treated with a nNOS inhibitor or nNOS-specific siRNA.	Arginine	39-49	nitric oxide synthase 1	Rattus norvegicus	199-203
28754372-9	2017	Additionally, intrathecal injection of l-arginine significantly attenuated mechanical or thermal hyperalgesia induced by nerve injury, and the l-arginine effect was diminished in rats treated with a nNOS inhibitor or nNOS-specific siRNA.	Arginine	39-49	nitric oxide synthase 1	Rattus norvegicus	217-221
28754372-9	2017	Additionally, intrathecal injection of l-arginine significantly attenuated mechanical or thermal hyperalgesia induced by nerve injury, and the l-arginine effect was diminished in rats treated with a nNOS inhibitor or nNOS-specific siRNA.	Arginine	143-153	nitric oxide synthase 1	Rattus norvegicus	199-203
28754372-9	2017	Additionally, intrathecal injection of l-arginine significantly attenuated mechanical or thermal hyperalgesia induced by nerve injury, and the l-arginine effect was diminished in rats treated with a nNOS inhibitor or nNOS-specific siRNA.	Arginine	143-153	nitric oxide synthase 1	Rattus norvegicus	217-221
28874563-5	2017	We present evidence that PRMT7-mediated monomethylation of histone H4 Arg-17 regulates PRMT5 activity at Arg-3 in the same protein.	Arginine	70-73	protein arginine methyltransferase 7	Homo sapiens	25-30
28874563-5	2017	We present evidence that PRMT7-mediated monomethylation of histone H4 Arg-17 regulates PRMT5 activity at Arg-3 in the same protein.	Arginine	105-108	protein arginine methyltransferase 7	Homo sapiens	25-30
28943853-7	2017	In line with this observation, age-associated increases in S6K1 signaling and p66Shc levels in heart are significantly attenuated in the female Arg-II-/- mice.	Arginine	144-147	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	59-63
28943853-7	2017	In line with this observation, age-associated increases in S6K1 signaling and p66Shc levels in heart are significantly attenuated in the female Arg-II-/- mice.	Arginine	144-147	src homology 2 domain-containing transforming protein C1	Mus musculus	78-84
28943853-10	2017	Genetic disruption of Arg-II in mouse extends lifespan predominantly in females, which relates to inhibition of S6K1, p66Shc, and p16INK4a.	Arginine	22-25	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	112-116
28943853-10	2017	Genetic disruption of Arg-II in mouse extends lifespan predominantly in females, which relates to inhibition of S6K1, p66Shc, and p16INK4a.	Arginine	22-25	src homology 2 domain-containing transforming protein C1	Mus musculus	118-124
28497977-6	2017	Only virus with arginine substitution at position 11 seemed to be involved in CXCR4 coreceptor usage.	Arginine	16-24	C-X-C motif chemokine receptor 4	Homo sapiens	78-83
28870898-6	2017	Our studies indicated that ATA strongly inactivates and binds in the PTP1B and SHP2 active site, interacting with arginine residue essential for enzyme activity.	Arginine	114-122	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	79-83
28655788-3	2017	In particular, loss of Prmt1 led to a decrease in arginine methylation of the translation initiation complex, thereby disrupting its assembly and inhibiting translation.	Arginine	50-58	protein arginine methyltransferase 1	Homo sapiens	23-28
28757206-2	2017	In higher eukaryotes, PRMT5 catalyzes Arg symmetric dimethylation, including key components of the spliceosome.	Arginine	38-41	SHK1 binding protein 1	Arabidopsis thaliana	22-27
28757206-7	2017	Moreover, the salt-induced Arg symmetric dimethylation is abolished in PRMT5C125S/prmt5-1 plants, correlated to aberrant splicing of pre-mRNA derived from a stress-related gene.	Arginine	27-30	SHK1 binding protein 1	Arabidopsis thaliana	82-87
28810879-5	2017	RESULTS: Despite inherent limitations due to amino acid sequence constraints, all the PRISM-SRM assays developed using Arg-C digestion showed a linear dynamic range of at least two orders of magnitude, with limits of quantification ranged from 0.1 to 1 fmol/mug of total protein in the cell lysate.	Arginine	119-122	PR/SET domain 6	Homo sapiens	86-91
28808255-4	2017	We find that the mitochondrial form of arginase (ARG2), which hydrolyzes arginine into ornithine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses PDA.	Arginine	73-81	arginase 2	Homo sapiens	49-53
28808255-5	2017	In vivo infusion of 15N-glutamine in obese mouse models of PDA demonstrates enhanced nitrogen flux into the urea cycle and infusion of 15N-arginine shows that Arg2 loss causes significant ammonia accumulation that results from the shunting of arginine catabolism into alternative nitrogen repositories.	Arginine	139-147	arginase type II	Mus musculus	159-163
28652407-1	2017	Protein arginine methyltransferase 1 (PRMT1) is an essential enzyme controlling about 85% of the total cellular arginine methylation in proteins.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
28652407-4	2017	Here, we sought to determine whether c-Myc in myeloid cells is regulated by PRMT1-dependent arginine methylation.	Arginine	92-100	protein arginine methyltransferase 1	Homo sapiens	76-81
28797075-1	2017	AIMS: Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals.	Arginine	6-14	arginase 2	Homo sapiens	73-83
28797075-1	2017	AIMS: Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals.	Arginine	6-14	arginase 2	Homo sapiens	85-89
28656289-0	2017	PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.	Arginine	79-87	protein arginine methyltransferase 1	Homo sapiens	0-5
28656289-0	2017	PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.	Arginine	79-87	protein arginine methyltransferase 1	Homo sapiens	127-132
28695314-8	2017	Competence of SlCAT2 for Arg transport was demonstrated measuring uptake of [3H]Arg in proteoliposomes which was trans-stimulated by internal Arg or ornithine.	Arginine	25-28	catalase isozyme 2	Solanum lycopersicum	14-20
28695314-8	2017	Competence of SlCAT2 for Arg transport was demonstrated measuring uptake of [3H]Arg in proteoliposomes which was trans-stimulated by internal Arg or ornithine.	Arginine	80-83	catalase isozyme 2	Solanum lycopersicum	14-20
28791021-4	2017	Arginine can be recycled in certain mammalian tissues from citrulline via argininosuccinate (ASA) in a two-step enzymatic process involving the enzymes argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL).	Arginine	0-8	argininosuccinate lyase	Homo sapiens	189-212
28791021-5	2017	Here, we demonstrate that anti-CD3/anti-CD28-activated human primary CD4+ and CD8+ T cells upregulate ASS expression in response to low extracellular arginine concentrations, while ASL is expressed constitutively.	Arginine	150-158	CD8a molecule	Homo sapiens	78-81
28587924-1	2017	Protein arginine methyltransferase 7 (PRMT7) catalyzes the introduction of monomethylation marks at the arginine residues of substrate proteins.	Arginine	8-16	protein arginine methyltransferase 7	Homo sapiens	38-43
28903384-6	2017	Mechanistic studies further revealed that PRMT5 (Protein arginine methyltransferase 5), responsible for catalyzing arginine methylation on histones, is a novel cofactor of SHARPIN.	Arginine	57-65	SHANK associated RH domain interactor	Homo sapiens	172-179
28592444-4	2017	Combining individual-resolution cross-linking and immunoprecipitation (iCLIP) and mass spectrometry, we show that elevated arginine methylation of SRSF5 and lower phosphorylation levels of cobound SRSF2 enhance shuttling of SRSF5 in P19 cells by modulating protein-protein and protein-RNA interactions.	Arginine	123-131	serine and arginine rich splicing factor 5	Homo sapiens	147-152
28592444-4	2017	Combining individual-resolution cross-linking and immunoprecipitation (iCLIP) and mass spectrometry, we show that elevated arginine methylation of SRSF5 and lower phosphorylation levels of cobound SRSF2 enhance shuttling of SRSF5 in P19 cells by modulating protein-protein and protein-RNA interactions.	Arginine	123-131	serine and arginine rich splicing factor 5	Homo sapiens	224-229
28969007-3	2017	Arginine is a semi-essential amino acid that is imported from the extracellular microenvironment or recycled from intracellular precursors through the combined expression of the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) enzymes.	Arginine	0-8	argininosuccinate lyase	Homo sapiens	257-280
28969007-3	2017	Arginine is a semi-essential amino acid that is imported from the extracellular microenvironment or recycled from intracellular precursors through the combined expression of the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS) and argininosuccinate lyase (ASL) enzymes.	Arginine	0-8	argininosuccinate lyase	Homo sapiens	282-285
28334903-6	2017	The Arg-Gly-Gly repeats within the low-complexity region are required for binding to the RNA motif exposed by m6A methylation.	Arginine	4-7	glycoprotein M6A	Homo sapiens	110-113
28392442-0	2017	Protein arginine methylation of Npl3 promotes splicing of the SUS1 intron harboring non-consensus 5" splice site and branch site.	Arginine	8-16	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	32-36
28392442-2	2017	Here we provide evidence that protein arginine methylation of the yeast SR-/hnRNP-like protein Npl3 plays a role in facilitating efficient splicing of the SUS1 intron that harbors a non-consensus 5" splice site and branch site.	Arginine	38-46	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	95-99
28392442-4	2017	Using an Npl3 mutant that phenocopies wild-type Npl3 when expressed in Deltahmt1 cells, we showed that the arginine methylation of Npl3 is responsible for this.	Arginine	107-115	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	9-13
28392442-4	2017	Using an Npl3 mutant that phenocopies wild-type Npl3 when expressed in Deltahmt1 cells, we showed that the arginine methylation of Npl3 is responsible for this.	Arginine	107-115	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	48-52
28392442-4	2017	Using an Npl3 mutant that phenocopies wild-type Npl3 when expressed in Deltahmt1 cells, we showed that the arginine methylation of Npl3 is responsible for this.	Arginine	107-115	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	48-52
28392442-8	2017	Based on these data, we propose a model in which Hmt1, via arginine methylation of Npl3, facilitates U1 snRNP engagement with the pre-mRNA to promote usage of non-consensus splice sites by the splicing machinery.	Arginine	59-67	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	83-87
28566767-6	2017	The "His carrier" (His/His or His/Arg) of rs1229984 (His48Arg) of ADH1B significantly increased gout risk (P = 4.3 x 10-4, odds ratio = 1.76), as did the "non-Lys carrier (Glu/Glu)" of rs671 (Glu504Lys) of ALDH2.	Arginine	34-37	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	66-71
28279929-2	2017	When located on the plasma membrane, full-length 135kDa CDCP1 can undergo proteolysis mediated by serine proteases that cleave after two adjacent amino acids (arginine 368 and lysine 369).	Arginine	159-167	CUB domain containing protein 1	Homo sapiens	56-61
28515311-3	2017	Diverse proteins (in addition to Chk1) that are shown here to be targeted for degradation by the Arg/N-end rule pathway in naa10Delta cells include Kar4, Tup1, Gpd1, Ste11, and also, remarkably, the main Hsp90 chaperone (Hsc82) itself.	Arginine	97-100	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	160-164
28516893-11	2017	Since PEG is a synthetic polymer devoid of cell attachment sites, we could overcome this limitation by tethering Arg-Gly-Asp-Ser (RGDS) peptide to the PEG hydrogel microspheres; upon RGDS tethering, we observed uniform cell dispersion.	Arginine	113-116	ral guanine nucleotide dissociation stimulator	Mus musculus	130-134
28516893-11	2017	Since PEG is a synthetic polymer devoid of cell attachment sites, we could overcome this limitation by tethering Arg-Gly-Asp-Ser (RGDS) peptide to the PEG hydrogel microspheres; upon RGDS tethering, we observed uniform cell dispersion.	Arginine	113-116	ral guanine nucleotide dissociation stimulator	Mus musculus	183-187
28093506-3	2017	Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes.	Arginine	52-60	TYRO3 protein tyrosine kinase 3	Mus musculus	90-95
28093506-3	2017	Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes.	Arginine	52-60	TYRO3 protein tyrosine kinase 3	Mus musculus	104-121
28093506-3	2017	Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes.	Arginine	52-60	TYRO3 protein tyrosine kinase 3	Mus musculus	123-128
27211852-6	2017	Finally, a functional analysis indicated that the replacement of the 47th amino acid tryptophan (W47) with arginine (W47R) or glycine (W47G) led to reduced activity of alpha-galactosidase A in 293T cells.	Arginine	107-115	galactosidase alpha	Homo sapiens	168-189
28487700-0	2017	l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-beta, Production by Neonatal Regulatory T Lymphocytes.	Arginine	0-10	interleukin 10	Homo sapiens	46-60
28487700-5	2017	In this study, we have further investigated how exogenous l-arginine enhances neonatal regulatory T-cells (Tregs) function in relation to IL-10 production under epigenetic regulation.	Arginine	58-68	interleukin 10	Homo sapiens	138-143
28487700-7	2017	Addition of exogenous l-arginine had no effect on transforming growth factor-beta production by PBMCs or CBMCs, but enhanced IL-10 production by neonatal CD4+CD25+FoxP3+ Tregs.	Arginine	22-32	interleukin 10	Homo sapiens	125-130
28100476-7	2017	Glucose-, arginine-, and leucine-stimulated insulin secretion all were lower (P &lt; 0.05) in anemic fetuses.	Arginine	10-18	LOC105613195	Ovis aries	44-51
27882480-13	2017	Early initiation of lysine-restricted diet and/or arginine therapy likely improved neurodevelopmental outcome in young patients with PDE-ALDH7A1.	Arginine	50-58	aldehyde dehydrogenase 7 family member A1	Homo sapiens	133-144
28093224-1	2017	The Arg/Arg homozygosity at codon 16 of the beta-2-adrenoreceptor (ADRB2) gene has been thought to predispose asthma patients to a poorer therapeutic response to beta-2-mimetics, or to worse control of the disease.	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	44-65
28358054-0	2017	Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer.	Arginine	73-81	DEP domain containing MTOR interacting protein	Homo sapiens	100-106
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	38-43	solute carrier family 7 member 1	Homo sapiens	138-142
28334039-10	2017	CONCLUSION: The inhibitory effects of L-Arg on IL-1beta-mediated NF-kappaB-activation in Caco-2 cells involve L-Arg transport activity by CAT1, regulation of IL-1beta-mediated increases in NF-kappaB expression, changes in iNOS expression and NO production.	Arginine	110-115	solute carrier family 7 member 1	Homo sapiens	138-142
28611978-8	2017	Oral bacteria peptidylarginine deiminases might lead to the p53 and K-ras point mutations by degrading arginine.	Arginine	22-30	KRAS proto-oncogene, GTPase	Homo sapiens	68-73
28028182-0	2017	Domain Mapping of Heat Shock Protein 70 Reveals That Glutamic Acid 446 and Arginine 447 Are Critical for Regulating Superoxide Dismutase 2 Function.	Arginine	75-83	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-39
28649316-1	2017	Protein arginine methyltransferase 1 (PRMT1) is a key player for the dynamic regulation of arginine methylation.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	38-43
28035420-3	2017	Our laboratory has previously demonstrated that arginine metabolic enzyme argininosuccinate lyase (ASL) promoted HCC formation in part via maintenance of cyclin A2 protein expression and arginine production for channeling to nitric oxide synthase.	Arginine	48-56	argininosuccinate lyase	Homo sapiens	74-97
28035420-3	2017	Our laboratory has previously demonstrated that arginine metabolic enzyme argininosuccinate lyase (ASL) promoted HCC formation in part via maintenance of cyclin A2 protein expression and arginine production for channeling to nitric oxide synthase.	Arginine	48-56	argininosuccinate lyase	Homo sapiens	99-102
28035420-3	2017	Our laboratory has previously demonstrated that arginine metabolic enzyme argininosuccinate lyase (ASL) promoted HCC formation in part via maintenance of cyclin A2 protein expression and arginine production for channeling to nitric oxide synthase.	Arginine	187-195	argininosuccinate lyase	Homo sapiens	74-97
28035420-3	2017	Our laboratory has previously demonstrated that arginine metabolic enzyme argininosuccinate lyase (ASL) promoted HCC formation in part via maintenance of cyclin A2 protein expression and arginine production for channeling to nitric oxide synthase.	Arginine	187-195	argininosuccinate lyase	Homo sapiens	99-102
28035420-8	2017	Furthermore, overexpression of ASL conferred resistance to arginine deprivation therapy.	Arginine	59-67	argininosuccinate lyase	Homo sapiens	31-34
28035420-12	2017	Overexpression of ASL may be a contributing factor in drug resistance for arginine deprivation therapy.	Arginine	74-82	argininosuccinate lyase	Homo sapiens	18-21
27849571-0	2017	Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	24-29
27849571-10	2017	These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	52-57
27757983-6	2017	In mouse peritoneal macrophages and aortic endothelial cells (MAECs), PARP-1 knockout resulted in lowered Arg II expression.	Arginine	106-109	poly (ADP-ribose) polymerase family, member 1	Mus musculus	70-76
27757983-9	2017	Our findings indicate that PARP-1 inhibition may attenuate atherogenesis by restoring NO production in endothelial cells and thus by reducing Arg II expression and consequently arginase the activity.	Arginine	142-145	poly (ADP-ribose) polymerase family, member 1	Mus musculus	27-33
28222024-0	2017	Eff ects of hemin, a heme oxygenase-1 inducer in L-arginine-induced acute pancreatitis and associated lung injury in adult male albino rats.	Arginine	49-59	heme oxygenase 1	Rattus norvegicus	21-37
28222024-1	2017	OBJECTIVE: The aim of the current study was to assess the protective outcome of hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats.	Arginine	124-134	heme oxygenase 1	Rattus norvegicus	89-105
28222024-1	2017	OBJECTIVE: The aim of the current study was to assess the protective outcome of hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats.	Arginine	124-134	heme oxygenase 1	Rattus norvegicus	107-111
28222024-8	2017	CONCLUSIONS: The current study indicates that the induction of HO-1 by hemin pre-treatment significantly ameliorated the L-arginine-induced pancreatitis and associated pulmonary complications may be due to its anti-inflammatory and antioxidant properties.	Arginine	121-131	heme oxygenase 1	Rattus norvegicus	63-67
28478454-3	2017	Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown to modulate eNOS activity.	Arginine	12-20	solute carrier family 7 member 1	Homo sapiens	51-84
28478454-3	2017	Delivery of arginine to membrane bound eNOS by the cationic amino acid transporter-1 (CAT-1) has been shown to modulate eNOS activity.	Arginine	12-20	solute carrier family 7 member 1	Homo sapiens	86-91
28478454-4	2017	The current studies were designed to test the hypothesis that VEGF enhances eNOS activity via modulation of arginine transport by CAT-1.	Arginine	108-116	solute carrier family 7 member 1	Homo sapiens	130-135
28478454-14	2017	CONCLUSIONS: VEGF increases arginine transport via modulation of CAT-1 in endothelial cells.	Arginine	28-36	solute carrier family 7 member 1	Homo sapiens	65-70
27974050-8	2016	In supplemented females, arginine-stimulated insulin secretion was increased in preterm but reduced in term-born juveniles compared with controls (repeated-measures ANOVA P&lt;0 01).	Arginine	25-33	LOC105613195	Ovis aries	45-52
27614253-3	2016	This cycle indicates that argininosuccinate synthase (ASS) catalyzes l-citrulline (l-cit) conversion to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms l-arginine (l-arg), the substrate for NO synthesis.	Arginine	199-204	argininosuccinate lyase	Homo sapiens	163-186
27880901-6	2016	However, GCN2-deficient CD8+ T cells fail to proliferate in limiting tryptophan, arginine, leucine, lysine, or asparagine, the opposite of what previous studies concluded.	Arginine	81-89	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	9-13
27840030-0	2016	Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer.	Arginine	0-8	coactivator associated arginine methyltransferase 1	Homo sapiens	32-37
27840030-8	2016	Our study reveals that arginine methylation of MDH1 by CARM1 regulates cellular redox homeostasis and suppresses glutamine metabolism of pancreatic cancer.	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	55-60
27717730-7	2016	Our results showed that the augmented interaction of p47PHOX with gp91PHOX subunits of the enzyme in skeletal muscle tissue in the offspring of diabetic rats (DV) was abolished after l-Arg treatment in DA rats.	Arginine	183-188	cytochrome b-245 beta chain	Rattus norvegicus	66-74
27613419-11	2016	Our results establish that arginine methylation augments Scd6 repression activity by promoting eIF4G1-binding.	Arginine	27-35	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	95-101
27560450-5	2016	Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta.	Arginine	36-39	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	169-172
27560450-5	2016	Consistently, the inhibition of the Arg/N-end rule pathway with PCA significantly elevated levels of MAPT and huntingtin aggregates, accompanied by increased numbers of LC3 and SQSTM1 puncta.	Arginine	36-39	sequestosome 1	Homo sapiens	177-183
26540586-4	2016	All PCGs start with a methionine (M) amino acid except the COI gene which has an arginine (R).	Arginine	81-89	COX1	Heliothis subflexa	59-62
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Arginine	33-36	uroplakin 2	Homo sapiens	78-82
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Arginine	33-36	uroplakin 2	Homo sapiens	155-159
27822012-9	2016	Myocardial eNOS protein level was elevated in the l-arginine group and PlGF + l-arginine group (P&lt;0.01).	Arginine	50-60	nitric oxide synthase 3	Rattus norvegicus	11-15
27822012-9	2016	Myocardial eNOS protein level was elevated in the l-arginine group and PlGF + l-arginine group (P&lt;0.01).	Arginine	78-88	nitric oxide synthase 3	Rattus norvegicus	11-15
27822012-9	2016	Myocardial eNOS protein level was elevated in the l-arginine group and PlGF + l-arginine group (P&lt;0.01).	Arginine	78-88	placental growth factor	Rattus norvegicus	71-75
27822012-13	2016	l-arginine increases the expression of the eNOS protein.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	43-47
27822012-14	2016	PlGF and l-arginine have a more pronounced, synergistic protective effect on myocardial protection compared with that of exogenous PlGF therapy alone.	Arginine	9-19	placental growth factor	Rattus norvegicus	131-135
27565025-7	2016	Furthermore, neuronal expression of mutant PlexA robustly restored defasciculation defects in PlexA null mutants when the catalytic arginine fingers of the PlexA RasGAP domain critical for GAP activity were disrupted.	Arginine	132-140	Plexin A	Drosophila melanogaster	43-48
27565025-7	2016	Furthermore, neuronal expression of mutant PlexA robustly restored defasciculation defects in PlexA null mutants when the catalytic arginine fingers of the PlexA RasGAP domain critical for GAP activity were disrupted.	Arginine	132-140	Plexin A	Drosophila melanogaster	94-99
27565025-7	2016	Furthermore, neuronal expression of mutant PlexA robustly restored defasciculation defects in PlexA null mutants when the catalytic arginine fingers of the PlexA RasGAP domain critical for GAP activity were disrupted.	Arginine	132-140	Plexin A	Drosophila melanogaster	94-99
26659718-6	2016	RESULTS: Nine arginine residues within FBG were citrullinated by PAD2 and PAD4.	Arginine	14-22	peptidyl arginine deiminase 2	Homo sapiens	65-69
27514743-4	2016	The N-terminal Gly/Arg-rich domain (GAR domain) of TRF2 directly binds to the globular domain of core histones.	Arginine	19-22	telomeric repeat binding factor 2	Homo sapiens	51-55
27514743-5	2016	The conserved arginine residues in the GAR domain of TRF2 are required for this interaction.	Arginine	14-22	telomeric repeat binding factor 2	Homo sapiens	53-57
27514743-6	2016	A TRF2 mutant with these arginine residues substituted by alanine lost the ability to protect telomeres and induced rapid telomere shortening caused by the cleavage of a loop structure of the telomeric chromatin.	Arginine	25-33	telomeric repeat binding factor 2	Homo sapiens	2-6
27648300-0	2016	Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.	Arginine	28-36	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	60-67
27648300-2	2016	CASTOR1 is shown to be an arginine sensor, which plays an important role in the activation of the mTORC1 pathway.	Arginine	26-34	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	0-7
27648300-3	2016	In the deficiency of arginine, CASTOR1 interacts with GATOR2, which together with GATOR1 and Rag GTPases controls the relocalization of mTORC1 to lysosomes.	Arginine	21-29	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	31-38
27648300-4	2016	The binding of arginine to CASTOR1 disrupts its association with GATOR2 and hence activates the mTORC1 signaling.	Arginine	15-23	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	27-34
27648300-5	2016	Here, we report the crystal structure of CASTOR1 in complex with arginine at 2.5 A resolution.	Arginine	65-73	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	41-48
27648300-7	2016	ACT1 and ACT3 adopt the typical betaalphabetabetaalphabeta topology and function in dimerization via the conserved residues from helices alpha1 of ACT1 and alpha5 of ACT3; whereas ACT 2 and ACT4, both comprising of two non-sequential regions, assume the unusual betabetaalphabetabetaalpha topology and contribute an arginine-binding pocket at the interface.	Arginine	316-324	TRAF3 interacting protein 2	Homo sapiens	0-4
27648300-10	2016	Our structural and functional data together reveal the molecular basis for the arginine-binding specificity of CASTOR1 in the arginine-dependent activation of the mTORC1 signaling.	Arginine	79-87	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	111-118
27648300-10	2016	Our structural and functional data together reveal the molecular basis for the arginine-binding specificity of CASTOR1 in the arginine-dependent activation of the mTORC1 signaling.	Arginine	126-134	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	111-118
28042453-2	2016	CARM1 methylates histone 3 arginines 17 and 26, as well as numerous non-histone proteins including CBP/p300, SRC-3, NCOA2, PABP1, and SAP49, while also functioning as a coactivator for various proteins that have been linked to cancer such as p53, NF-kappabeta, beta-catenin, E2F1 and steroid hormone receptor ERalpha.	Arginine	27-36	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
27487210-0	2016	Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.	Arginine	13-21	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	33-40
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	0-8	solute carrier family 38 member 9	Homo sapiens	117-124
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	0-8	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	188-195
27487210-3	2016	Arginine activates mTORC1 upstream of the Rag family of GTPases, through either the lysosomal amino acid transporter SLC38A9 or the GATOR2-interacting Cellular Arginine Sensor for mTORC1 (CASTOR1).	Arginine	160-168	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	188-195
27487210-5	2016	Here, we present the 1.8 A crystal structure of arginine-bound CASTOR1.	Arginine	48-56	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	63-70
27487210-6	2016	Homodimeric CASTOR1 binds arginine at the interface of two Aspartate kinase, Chorismate mutase, TyrA (ACT) domains, enabling allosteric control of the adjacent GATOR2-binding site to trigger dissociation from GATOR2 and downstream activation of mTORC1.	Arginine	26-34	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	12-19
27487210-7	2016	Our data reveal that CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases, suggesting that the mTORC1 pathway exploited an ancient, amino-acid-dependent allosteric mechanism to acquire arginine sensitivity.	Arginine	254-262	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	21-28
27461362-7	2016	Moreover, cerulein- and arginine-induced serum amylase and lipase were significantly higher in panc-PTP1B KO mice compared with controls.	Arginine	24-32	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	100-105
27461362-9	2016	Furthermore, panc-PTP1B KO mice exhibited enhanced cerulein- and arginine-induced NF-kappaB inflammatory response accompanied with increased mitogen-activated protein kinases activation and elevated endoplasmic reticulum stress.	Arginine	65-73	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	18-23
27461362-11	2016	These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis.	Arginine	73-81	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	50-55
27293070-1	2016	The docking approach for the screening of designed small molecule ligands, led to the identification of a critical arginine residue in peptide deformylase for spiro cyclopropyl PDF inhibitor"s extra hydrophobic binding, providing us a useful tool for searching more efficient PDF inhibitors to fight for horrifying antibiotics resistance.	Arginine	115-123	peptide deformylase (mitochondrial)	Rattus norvegicus	276-279
27450204-9	2016	Furthermore, Arg/Arg genotype of ADH1B Arg47His variant combined with drinking, smoking and males appeared to show a high risk in patients with esophageal cancer.	Arginine	13-16	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	33-38
27450204-9	2016	Furthermore, Arg/Arg genotype of ADH1B Arg47His variant combined with drinking, smoking and males appeared to show a high risk in patients with esophageal cancer.	Arginine	17-20	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	33-38
27733338-6	2016	As a control group, mutation of a single arginine (R42A) within the destruction box inactivates the MD leading to constitutive expression of MD*-CTCF.	Arginine	41-49	CCCTC-binding factor	Homo sapiens	145-149
27287681-9	2016	SIGNIFICANCE: Exogenous l-arginine diminished metalloproteinase-2 and -9 activities and MMP-9/TIMP-1 ratio along with restoring the oxidative stress balance in patients with hypertension.	Arginine	24-34	matrix metallopeptidase 9	Homo sapiens	88-93
26919654-11	2016	ABBREVIATIONS: ACTN3 = alpha-actinin-3 BMI = body mass index CVD = cardiovascular disease HDL-C = high-density lipoprotein cholesterol LDL-C = low-density lipoprotein cholesterol R = arginine (R) at amino acid position 577 of the ACTN3 protein TC = total cholesterol TG = triglyceride X = truncation at amino acid position 577 of the ACTN3 protein.	Arginine	183-191	actinin alpha 3	Homo sapiens	15-20
26774659-1	2016	BACKGROUND: The Gly-to-Arg substitution at the 16 position (rs1042713) in the beta2-adrenoceptor gene (ADRB2) is associated with enhanced downregulation and uncoupling of beta2-receptors.	Arginine	23-26	adrenoceptor beta 2	Homo sapiens	78-96
26774659-1	2016	BACKGROUND: The Gly-to-Arg substitution at the 16 position (rs1042713) in the beta2-adrenoceptor gene (ADRB2) is associated with enhanced downregulation and uncoupling of beta2-receptors.	Arginine	23-26	adrenoceptor beta 2	Homo sapiens	103-108
27212567-0	2016	A Prospective Case Study of the Safety and Efficacy of Lysine-Restricted Diet and Arginine Supplementation Therapy in a Patient With Pyridoxine-Dependent Epilepsy Caused by Mutations in ALDH7A1.	Arginine	82-90	aldehyde dehydrogenase 7 family member A1	Homo sapiens	186-193
27212567-2	2016	PATIENT DESCRIPTION AND RESULTS: We present a three-year treatment outcome of a child with PDE-ALDH7A1 on pyridoxine (started at age three weeks of age), lysine-restricted diet (started at age seven months), and arginine supplementation therapy (started at age 26 months).	Arginine	212-220	aldehyde dehydrogenase 7 family member A1	Homo sapiens	91-102
27129265-7	2016	This stands in stark contrast to cationic trypsinogen where single mutations of either Leu-81 or Arg-122 resulted in almost complete resistance to CTRC-mediated degradation.	Arginine	97-100	chymotrypsin C	Homo sapiens	147-151
27282200-7	2016	According to all predictors, mutation in KCNH1 is damaging de novo mutation that results in substitution of Glycine by Arginine, i.e., p.(Gly348Arg).	Arginine	119-127	potassium voltage-gated channel subfamily H member 1	Homo sapiens	41-46
26940553-10	2016	Our results show that conserved arginine residues play critical roles in interaction with Geminin and Mcm that are crucial for proper conformation of the complexes and its licensing activity.	Arginine	32-40	mucin 2	Mus musculus	102-105
26937714-7	2016	Interestingly, AD-controls had lower glucose- and arginine-stimulated insulin concentrations than intact-controls, but AD-IUGR and AD-control insulin responses were not different.	Arginine	50-58	LOC105613195	Ovis aries	70-77
26819315-8	2016	As an example, methylation of quaking protein in Arg(242) and Arg(256) in SK-Hep1+ cells may play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27(kip1) The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP+- mice.	Arginine	49-52	methylthioadenosine phosphorylase	Homo sapiens	245-249
26819315-8	2016	As an example, methylation of quaking protein in Arg(242) and Arg(256) in SK-Hep1+ cells may play a pivotal role in the regulation of its activity as indicated by the up-regulation of its target protein p27(kip1) The phenotype associated with a MTAP deficiency was further verified in the liver of MTAP+- mice.	Arginine	62-65	methylthioadenosine phosphorylase	Homo sapiens	245-249
25952544-7	2016	As one of puerarin-upregulated proteins, mitochondrial arginase-2 hydrolyzes L-arginine to L-ornithine, thereby competing with neuronal NOS for substrate L-arginine in mitochondria.	Arginine	77-87	arginase 2	Rattus norvegicus	55-65
25952544-7	2016	As one of puerarin-upregulated proteins, mitochondrial arginase-2 hydrolyzes L-arginine to L-ornithine, thereby competing with neuronal NOS for substrate L-arginine in mitochondria.	Arginine	154-164	arginase 2	Rattus norvegicus	55-65
27118147-5	2016	For the most active compound 20, we confirmed that it is a specific MD2 inhibitor through a series of biochemical experiments and elucidated that it binds to the hydrophobic pocket of MD2 via hydrogen bonds with Arg(90) and Tyr(102) residues.	Arginine	212-215	lymphocyte antigen 96	Rattus norvegicus	68-71
27118147-5	2016	For the most active compound 20, we confirmed that it is a specific MD2 inhibitor through a series of biochemical experiments and elucidated that it binds to the hydrophobic pocket of MD2 via hydrogen bonds with Arg(90) and Tyr(102) residues.	Arginine	212-215	lymphocyte antigen 96	Rattus norvegicus	184-187
26818656-10	2016	The former had a preference for the arginine-rich, flexible C terminus of HUb.	Arginine	36-44	ELAV like RNA binding protein 2	Homo sapiens	74-77
26771234-6	2016	Furthermore, our study uncovers that downregulation of deubiquitinase USP28 which results in more active c-Myc degradation via ubiquitin-proteasome machinery is the primary mechanism for inability to re-express ASS1 upon arginine deprivation in BR cells.	Arginine	221-229	ubiquitin specific peptidase 28	Homo sapiens	70-75
26771234-7	2016	Overexpression of USP28 in BR cells enhances c-Myc expression and hence increases ASS1 transcription upon arginine deprivation, and consequently leads to cell survival.	Arginine	106-114	ubiquitin specific peptidase 28	Homo sapiens	18-23
26555760-7	2016	In contrast, upon withdrawal of extracellular L-arginine, intracellular levels decreased as fast in SLC7A3-expressing cells compared with SLC7A1, but the efflux was slower via SLC7A2B.	Arginine	46-56	solute carrier family 7 member 3	Homo sapiens	100-106
26555760-7	2016	In contrast, upon withdrawal of extracellular L-arginine, intracellular levels decreased as fast in SLC7A3-expressing cells compared with SLC7A1, but the efflux was slower via SLC7A2B.	Arginine	46-56	solute carrier family 7 member 1	Homo sapiens	138-144
26503212-6	2016	We found that FAM98A, whose physiological function is unknown, was arginine-methylated by PRMT1.	Arginine	67-75	family with sequence similarity 98 member A	Homo sapiens	14-20
26503212-6	2016	We found that FAM98A, whose physiological function is unknown, was arginine-methylated by PRMT1.	Arginine	67-75	protein arginine methyltransferase 1	Homo sapiens	90-95
26832332-6	2016	Meanwhile, we found that substitution of arginine to serine at the site 57 decreases Tat transactivation of the HIV-1 LTR promoter.	Arginine	41-49	Tat	Human immunodeficiency virus 1	85-88
27028365-3	2016	The structure of AtTIP2;1 reveals an extended selectivity filter with the conserved arginine of the filter adopting a unique unpredicted position.	Arginine	84-92	delta tonoplast integral protein	Arabidopsis thaliana	17-25
27015302-3	2016	identify CASTOR1 as a direct arginine sensor that acts through the GATOR2 complex to regulate mTORC1.	Arginine	29-37	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	9-16
26551522-4	2016	Here, the crystal structures of human CARM1 with the S-adenosylmethione (SAM) mimic sinefungin and three different peptide sequences from histone H3 and PABP1 are presented, with both nonmethylated and singly methylated arginine residues exemplified.	Arginine	220-228	coactivator associated arginine methyltransferase 1	Homo sapiens	38-43
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	serine and arginine rich splicing factor 1	Homo sapiens	215-220
26797131-3	2016	We have previously identified nuclear speckle-related protein 70 (NSrp70) as a novel serine/arginine (SR)-related protein that co-localizes with classical SR proteins such as serine/arginine-rich splicing factor 1 (SRSF1 or ASF/SF2) and SRSF2 (SC35).	Arginine	92-100	serine and arginine rich splicing factor 1	Homo sapiens	224-231
27031716-5	2016	RESULTS: Administration of L-Arg at high doses caused an inhibition of tumor growth by 48 +- 8.0%, increase of superoxide radical generation rate and NO levels to a value of 1.23 +- 0.14 and 2.26 +- 0.31 nm/g tissue   min, and decreased activity of MMP-2 and -9 (3.55 +- 0.8 and 4.8 +- 1.0 r.u., respectively).	Arginine	27-32	matrix metallopeptidase 2	Mus musculus	249-261
27031716-6	2016	Treatment with L-Arg at low doses stimulated tumor growth and increased the levels of MMP-2 and -9 activities (8.44 +- 2.7 and 9.8 +- 3.1 r.u., respectively).	Arginine	15-20	matrix metallopeptidase 2	Mus musculus	86-98
27031716-11	2016	Upon combined use of L-Arg and SoQ10, superoxide radicals and NO form the redox state that causes decrease of MMP-2, -9 activities with consequent inhibition of tumor invasion and metastasis.	Arginine	21-26	matrix metallopeptidase 2	Mus musculus	110-115
26896718-7	2016	Presence of lysine and arginine residues that have been previously reported to undergo nonenzymatic glycosylation in CBS1 and CBS2 suggests that cetirizine transport in patients with diabetes could be altered.	Arginine	23-31	methionine sulfoxide reductase B2	Homo sapiens	117-121
26927806-7	2016	Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association.	Arginine	72-75	acyl-CoA thioesterase 8	Homo sapiens	66-71
26909965-1	2016	We aimed to investigate the role of XRCC1 codon 194 (Arg&gt;Trp), 280 (Arg&gt;His), and 399 (Arg&gt;Gln) polymorphisms in response to chemotherapy and the overall survival of gastric cancer patients.	Arginine	53-56	X-ray repair cross complementing 1	Homo sapiens	36-41
26909965-4	2016	By logistic regression analysis, we found that the Trp/Trp genotype of XRCC1 194 (Arg&gt;Trp) showed a stronger association with complete or partial response to chemotherapy compared to the Arg/Arg genotype, and the adjusted odds ratio (95%CI) was 0.17 (0.05-0.58).	Arginine	82-85	X-ray repair cross complementing 1	Homo sapiens	71-76
26909965-4	2016	By logistic regression analysis, we found that the Trp/Trp genotype of XRCC1 194 (Arg&gt;Trp) showed a stronger association with complete or partial response to chemotherapy compared to the Arg/Arg genotype, and the adjusted odds ratio (95%CI) was 0.17 (0.05-0.58).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	71-76
26909965-4	2016	By logistic regression analysis, we found that the Trp/Trp genotype of XRCC1 194 (Arg&gt;Trp) showed a stronger association with complete or partial response to chemotherapy compared to the Arg/Arg genotype, and the adjusted odds ratio (95%CI) was 0.17 (0.05-0.58).	Arginine	190-193	X-ray repair cross complementing 1	Homo sapiens	71-76
26909965-6	2016	In conclusion, we found that the XRCC1 194 (Arg&gt;Trp) polymorphism was correlated with a better response to chemotherapy and a low risk of death in patients with gastric cancer.	Arginine	44-47	X-ray repair cross complementing 1	Homo sapiens	33-38
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Arginine	65-73	succinate dehydrogenase complex assembly factor 1	Homo sapiens	0-6
26749241-3	2016	SDHAF1 transiently binds to aromatic peptides of SDHB through an arginine-rich region in its C terminus and specifically engages a Fe-S donor complex, consisting of the scaffold, holo-ISCU, and the co-chaperone-chaperone pair, HSC20-HSPA9, through an LYR motif near its N-terminal domain.	Arginine	65-73	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	49-53
26721445-0	2016	HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases.	Arginine	60-68	histone deacetylase 9	Homo sapiens	0-4
26833727-6	2016	The consensus C:G base pairs H-bond with conserved His or Arg residues in ZnF8, ZnF9, and ZnF11, and the consensus T:A base pair H-bonds with an Asn that replaces His in ZnF10.	Arginine	58-61	zinc finger protein 33A	Homo sapiens	90-95
26773858-10	2016	Further study demonstrated that the increase in ornithine level may result from the increased expression of arginase 2 in HUVECs, which mediates the hydrolysis of arginine to form ornithine.	Arginine	163-171	arginase 2	Homo sapiens	108-118
26813495-7	2016	Mechanistically, PRMT1 impacted EMT process and cellular senescence by mediating the asymmetric dimethylation of arginine 3 of histone H4 (H4R3me2as) at the ZEB1 promoter to activate its transcription, indicating the essential roles of this epigenetic control both in EMT and in senescence.	Arginine	113-121	protein arginine methyltransferase 1	Homo sapiens	17-22
26813495-7	2016	Mechanistically, PRMT1 impacted EMT process and cellular senescence by mediating the asymmetric dimethylation of arginine 3 of histone H4 (H4R3me2as) at the ZEB1 promoter to activate its transcription, indicating the essential roles of this epigenetic control both in EMT and in senescence.	Arginine	113-121	zinc finger E-box binding homeobox 1	Homo sapiens	157-161
27551491-0	2016	Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-gamma-induced malignant transformation of primary bovine mammary epithelial cells.	Arginine	22-30	interferon gamma	Bos taurus	95-111
27551491-8	2016	Furthermore, we found that IFN-gamma promoted arginine depletion, activated the general control nonderepressible-2 kinase (GCN2) signalling pathway and resulted in an increase in autophagic flux and the amount of autophagy in BMECs.	Arginine	46-54	interferon gamma	Bos taurus	27-36
27551491-9	2016	Overall, our findings are the first to demonstrate that arginine depletion and kinase GCN2 expression mediate IFN-gamma-induced autophagy that may promote malignant progression and that immunometabolism, autophagy and cancer are strongly correlated.	Arginine	56-64	interferon gamma	Bos taurus	110-119
26774283-2	2016	We show here that a dimer of the shelterin subunit TRF2 wraps ~ 90 bp of DNA through several lysine and arginine residues localized around its homodimerization domain.	Arginine	104-112	telomeric repeat binding factor 2	Homo sapiens	51-55
26799485-0	2016	Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice.	Arginine	0-3	small nucleolar RNA, H/ACA box 73a	Mus musculus	31-34
26742086-0	2016	Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.	Arginine	39-47	TSC complex subunit 2	Homo sapiens	11-15
26742086-7	2016	Arginine cooperates with growth factor signaling which further promotes dissociation of TSC2 from lysosomes and activation of mTORC1.	Arginine	0-8	TSC complex subunit 2	Homo sapiens	88-92
27221895-12	2016	While the XRCC1 Arg/Arg homozygote appeared to be a risk factor for CRC death, the association was not significant.	Arginine	16-19	X-ray repair cross complementing 1	Homo sapiens	10-15
26900409-4	2016	METHODS: The GNPs-Pep-A conjugate was prepared by functionalization of GNPs with peptide-A (Pro-His-Cys-Lys-Arg-Met; Pep-A) using thioctic acid as a linker molecule.	Arginine	108-111	carnosine dipeptidase 2	Homo sapiens	18-23
26971935-5	2016	Real-time PCR analysis revealed in APPwt cells significant decreases of ARG1 and ARG2 which are responsible for lysing arginine into ornithine and urea; this reduction was followed by significantly lower enzyme activity.	Arginine	119-127	arginase 2	Homo sapiens	81-85
29762971-5	2016	An activation of neuronal NO-synthase (nNOS) in those rats by injections of L-arginine in the medullary nuclei was accompanied by weakening of the hemodynamic effects compared to those in control rats.	Arginine	76-86	nitric oxide synthase 1	Rattus norvegicus	17-37
29762971-5	2016	An activation of neuronal NO-synthase (nNOS) in those rats by injections of L-arginine in the medullary nuclei was accompanied by weakening of the hemodynamic effects compared to those in control rats.	Arginine	76-86	nitric oxide synthase 1	Rattus norvegicus	39-43
26722375-3	2016	Of the imaging techniques that target angiogenesis, radiolabeled Arg-Gly-Asp (RGD) peptides have been a major focus because of their high affinity and selectivity for integrin alphavbeta3--one of the most extensively examined target of angiogenesis.	Arginine	65-68	integrin subunit alpha V	Homo sapiens	167-187
26692154-10	2015	In addition, the XRCC1 Arg/Gln genotype was associated with increased risk of UL after adjusting for age.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	17-22
26460953-0	2015	PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	0-5
26460953-2	2015	We here demonstrate that a protein arginine methyltransferase PRMT1, which are overexpressed in various types of cancer including lung and bladder cancer, methylates arginine 887 in an Aurora Kinase B (AURKB)-binding region of INCENP both in vitro and in vivo.	Arginine	35-43	protein arginine methyltransferase 1	Homo sapiens	62-67
26460953-2	2015	We here demonstrate that a protein arginine methyltransferase PRMT1, which are overexpressed in various types of cancer including lung and bladder cancer, methylates arginine 887 in an Aurora Kinase B (AURKB)-binding region of INCENP both in vitro and in vivo.	Arginine	35-43	aurora kinase B	Homo sapiens	202-207
26543086-5	2015	EDN had a greater number of glutamine amino acid residues, whereas ECP had a predominance of arginine.	Arginine	93-101	ribonuclease A family member 3	Homo sapiens	67-70
26450910-6	2015	Unlike the previously characterized Muscleblind (Mbl) circular RNA, which requires the Mbl protein for its biogenesis, we found that Laccase2 circular RNA levels are not controlled by Mbl or the Laccase2 gene product but rather by multiple hnRNP (heterogeneous nuclear ribonucleoprotein) and SR (serine-arginine) proteins acting in a combinatorial manner.	Arginine	303-311	straw	Drosophila melanogaster	133-141
26352190-4	2015	Molecular modeling suggests that Phe297 contributes to the construction of the substrate pocket of APB, which is wide enough to hold a chloride anion and allow the interaction of Gln169 with the N-terminal Arg residue of the substrate through bridging with the chloride anion.	Arginine	206-209	arginyl aminopeptidase	Homo sapiens	99-102
26457527-10	2015	This study provides useful clues concerning how the transition state of arginine may bind to carboxypeptidase B and therefore provides an insight into the structural basis of carboxypeptidase B selectivity, which is useful for the rational design of a carboxypeptidase with improved selectivity for industrial recombinant pro-insulin processing.	Arginine	72-80	carboxypeptidase B1	Homo sapiens	93-111
26457527-10	2015	This study provides useful clues concerning how the transition state of arginine may bind to carboxypeptidase B and therefore provides an insight into the structural basis of carboxypeptidase B selectivity, which is useful for the rational design of a carboxypeptidase with improved selectivity for industrial recombinant pro-insulin processing.	Arginine	72-80	carboxypeptidase B1	Homo sapiens	175-193
25865156-10	2015	Combination of ISO and ARG led to a decrease in cav-1 expression, a further increase in MYH7 expression and a down-regulation of MYH6 that inversely correlated with gp91phox mRNA levels.	Arginine	23-26	myosin heavy chain 6	Rattus norvegicus	129-133
25865156-10	2015	Combination of ISO and ARG led to a decrease in cav-1 expression, a further increase in MYH7 expression and a down-regulation of MYH6 that inversely correlated with gp91phox mRNA levels.	Arginine	23-26	cytochrome b-245 beta chain	Rattus norvegicus	165-173
26722464-4	2015	NO is synthesized by nitric oxide synthase (nNOS) from L-arginine and oxygen.	Arginine	55-65	nitric oxide synthase 1	Rattus norvegicus	44-48
26283571-8	2015	These results suggest that CAT-1 is a novel CAM that directly regulates endothelial integrity and mediates the protective actions of L-Arg to endothelium via a NO-independent mechanism.	Arginine	133-138	solute carrier family 7 member 1	Homo sapiens	27-32
26436388-4	2015	In this study, we used the amplification refractory mutation system (ARMS) and identified a single nucleotide change c.1555C&gt;T in exon 13 of the CACNA1F gene, leading to the substitution of arginine by tryptophan (p.R519W) in a Chinese individual affected by RP.	Arginine	193-201	calcium voltage-gated channel subunit alpha1 F	Homo sapiens	148-155
26010396-0	2015	Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.	Arginine	19-27	runt related transcription factor 1	Mus musculus	8-13
26010396-0	2015	Loss of RUNX1/AML1 arginine-methylation impairs peripheral T cell homeostasis.	Arginine	19-27	runt related transcription factor 1	Mus musculus	14-18
26010396-3	2015	Recent studies revealed that protein arginine methyltransferase 1 (PRMT1), which accounts for the majority of the type I PRMT activity in cells, methylates two arginine residues in RUNX1 (R206 and R210), and these modifications inhibit corepressor-binding to RUNX1 thereby enhancing its transcriptional activity.	Arginine	37-45	runt related transcription factor 1	Mus musculus	181-186
26010396-3	2015	Recent studies revealed that protein arginine methyltransferase 1 (PRMT1), which accounts for the majority of the type I PRMT activity in cells, methylates two arginine residues in RUNX1 (R206 and R210), and these modifications inhibit corepressor-binding to RUNX1 thereby enhancing its transcriptional activity.	Arginine	37-45	runt related transcription factor 1	Mus musculus	259-264
26010396-7	2015	These findings suggest that arginine-methylation of RUNX1 in the RTAMR-motif is dispensable for the development of definitive haematopoiesis and for steady-state platelet production, however this modification affects the role of RUNX1 in the maintenance of the peripheral CD4(+) T-cell population.	Arginine	28-36	runt related transcription factor 1	Mus musculus	52-57
26010396-7	2015	These findings suggest that arginine-methylation of RUNX1 in the RTAMR-motif is dispensable for the development of definitive haematopoiesis and for steady-state platelet production, however this modification affects the role of RUNX1 in the maintenance of the peripheral CD4(+) T-cell population.	Arginine	28-36	CD4 antigen	Mus musculus	272-275
26249842-8	2015	In addition, combined use of simulations and phylogenetic analysis has helped in the discovery of a new subfamily of Fic proteins that harbor a conserved Lys/Arg in place of the inhibitory Glu of the regulatory helix.	Arginine	158-161	C-C motif chemokine ligand 7	Homo sapiens	117-120
26234632-9	2015	The N-terminal domain is less likely to be associated with UDP-sugar selectivity, although, a conserved residue, Arg-259 (UGT2B7 numbering) in the UGT 1 and 2 families may influence UDP-sugar selectivity.	Arginine	113-116	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	122-128
25900360-2	2015	The three CcP variants have Arg-48, Trp-51, and His-52 mutated to either all alanine, CcP(triAla), all valine, CcP(triVal), or all leucine residues, CcP(triLeu).	Arginine	28-31	cytochrome-c peroxidase	Saccharomyces cerevisiae S288C	10-13
26067360-7	2015	They also showed an exercise-induced compensatory regulation of genes involved in biosynthesis and metabolism of amino acids (PSPH, GATM, NOS1 and GLDC), which responded to differences in the amino acid profile (consistently lower plasma levels of glycine, cysteine and arginine).	Arginine	270-278	phosphoserine phosphatase	Homo sapiens	126-130
26289097-9	2015	The N-terminal domain is less likely to be associated with UDP-sugar selectivity, although, a conserved residue, Arg-259 (UGT2B7 numbering) in the UGT 1 and 2 families may influence UDP-sugar selectivity.	Arginine	113-116	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	122-128
25993999-8	2015	sEH pharmacological inhibition before and after induction of pancreatitis mitigated cerulein- and arginine-induced AP.	Arginine	98-106	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
25998125-10	2015	Another dibasic motif (residues Arg-47, Arg-50) in the repeat 1 front alpha-helix is crucial for KCNQ2/3 but not Nav1.2 binding.	Arginine	32-35	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	97-104
25998125-10	2015	Another dibasic motif (residues Arg-47, Arg-50) in the repeat 1 front alpha-helix is crucial for KCNQ2/3 but not Nav1.2 binding.	Arginine	40-43	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	97-104
26034040-12	2015	USF1 complexes containing the histone H3 asymmetrically dimethylated on Arg-17 signature of PRMT4 are increased with LRP6-VKO.	Arginine	72-75	low density lipoprotein receptor-related protein 6	Mus musculus	117-121
26034040-14	2015	CONCLUSIONS: LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1- and arginine methylation-dependent relays.	Arginine	159-167	low density lipoprotein receptor-related protein 6	Mus musculus	13-17
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Arginine	114-117	lymphocyte antigen 96	Homo sapiens	58-62
25923908-6	2015	Moreover, experimental results of curcumin binding to the MD-2(R90A/Y102A) mutant further confirmed that residues ARG-90 and TYR-102 contribute to the recognition process of curcumin binding to the MD-2 protein.	Arginine	114-117	lymphocyte antigen 96	Homo sapiens	198-202
25690678-2	2015	The PRMT1 gene generates at least seven distinct alternatively spliced isoforms (PRMT v1-v7), which together contribute a significant portion of the cellular arginine methylome.	Arginine	158-166	protein arginine methyltransferase 1	Homo sapiens	4-9
25940089-6	2015	Of all these residues, tryptophan 79 (arginine 41 in H-RAS), in the interswitch region, modulates the effector selectivity of RAS proteins from H-RAS to E-RAS features.	Arginine	38-46	ES cell expressed Ras	Homo sapiens	153-158
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Arginine	264-267	protein phosphatase, Mg2+/Mn2+ dependent 1F	Homo sapiens	30-35
25994484-11	2015	Through extensive analysis of CaMKP-catalyzed dephosphorylation of various chimeric and point mutants of CaMKIdelta and CaMKIalpha, we identified the amino acid residues responsible for the phosphatase resistance of CaMKIdelta (Pro-57, Lys-62, Ser-66, Ile-68, and Arg-76).	Arginine	264-267	calcium/calmodulin dependent protein kinase I	Homo sapiens	120-130
26240838-5	2015	Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres.	Arginine	72-75	ral guanine nucleotide dissociation stimulator	Mus musculus	89-93
26002053-8	2015	RESULTS: Exome sequencing identified a homozygous arginine to glutamine mutation in amino acid position 383 (R383Q) in exon 5 of the SV2A gene.	Arginine	50-58	synaptic vesicle glycoprotein 2A	Homo sapiens	133-137
25861992-0	2015	Methylation of Gata3 protein at Arg-261 regulates transactivation of the Il5 gene in T helper 2 cells.	Arginine	32-35	GATA binding protein 3	Homo sapiens	15-20
25861992-3	2015	We herein identified a mechanism whereby the methylation of Gata3 at Arg-261 regulates the transcriptional activation of the Il5 gene in Th2 cells.	Arginine	69-72	GATA binding protein 3	Homo sapiens	60-65
25861992-6	2015	Thus, arginine methylation appears to play a pivotal role in the organization of Gata3 complexes and the target gene specificity of Gata3.	Arginine	6-14	GATA binding protein 3	Homo sapiens	81-86
25861992-6	2015	Thus, arginine methylation appears to play a pivotal role in the organization of Gata3 complexes and the target gene specificity of Gata3.	Arginine	6-14	GATA binding protein 3	Homo sapiens	132-137
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	131-134	coactivator associated arginine methyltransferase 1	Homo sapiens	106-111
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	coactivator associated arginine methyltransferase 1	Homo sapiens	106-111
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	coactivator associated arginine methyltransferase 1	Homo sapiens	99-104
25818198-6	2015	By in vitro assays and mutational analysis, we demonstrate that protein arginine methyltransferase PRMT4 (CARM1) methylates TP2 at Arg(71), Arg(75), and Arg(92) residues, and lysine methyltransferase KMT7 (Set9) methylates TP2 at Lys(88) and Lys(91) residues.	Arginine	140-143	coactivator associated arginine methyltransferase 1	Homo sapiens	106-111
25938407-5	2015	The XRCC1 399 Gln/Gln genotype and the XRCC1 194 Arg/Arg genotype were positively correlated to UC (OR [95%CI] = 2.27 [1.20-4.27] and 1.59 [1.06-2.36], respectively).	Arginine	49-52	X-ray repair cross complementing 1	Homo sapiens	39-44
25938407-5	2015	The XRCC1 399 Gln/Gln genotype and the XRCC1 194 Arg/Arg genotype were positively correlated to UC (OR [95%CI] = 2.27 [1.20-4.27] and 1.59 [1.06-2.36], respectively).	Arginine	53-56	X-ray repair cross complementing 1	Homo sapiens	39-44
25938407-7	2015	Participants with the XRCC1 (Arg399Gln) Gln/Gln genotype or the G-C/A-C haplotype of XRCC1 and a high urinary 8-OHdG level had a significantly higher risk of UC than those with the Arg/Arg + Arg/Gln genotype or the G-T haplotype and a low urinary 8-OHdG level.	Arginine	29-32	X-ray repair cross complementing 1	Homo sapiens	22-27
25765074-7	2015	Embryos cultured in 1.69mM arginine had lower SLC7A1 levels and a higher abundance of messages involved with glycolysis (hexokinase 1, hexokinase 2 and glutamic pyruvate transaminase (alanine aminotransferase) 2) and decreased expression of genes involved with blocking the tricarboxylic acid cycle (pyruvate dehydrogenase kinase, isozyme 1) and the pentose phosphate pathway (transaldolase 1).	Arginine	27-35	solute carrier family 7 member 1	Homo sapiens	46-52
25765074-7	2015	Embryos cultured in 1.69mM arginine had lower SLC7A1 levels and a higher abundance of messages involved with glycolysis (hexokinase 1, hexokinase 2 and glutamic pyruvate transaminase (alanine aminotransferase) 2) and decreased expression of genes involved with blocking the tricarboxylic acid cycle (pyruvate dehydrogenase kinase, isozyme 1) and the pentose phosphate pathway (transaldolase 1).	Arginine	27-35	glutamic--pyruvic transaminase 2	Homo sapiens	184-211
25925198-6	2015	L-Arg treatment increased the population of CD4(+)T-bet(+)IFN-gamma(+) Th1 cells and the activated macrophages (F4/80(+)CD36(+)) in the spleen.	Arginine	0-5	negative elongation factor complex member C/D	Homo sapiens	71-74
25925198-10	2015	Taken together, these data suggest that L-Arg may enhance the Th1 immune response, which is essential for a protective response in uncomplicated malaria but could be lethal in CM patients.	Arginine	40-45	negative elongation factor complex member C/D	Homo sapiens	62-65
25878270-5	2015	Pharmacologic disruption of the arginine utilization pathway by an inhibitor of arginase and ornithine decarboxylase protected the mice from AD-like pathology and significantly decreased CD11c expression.	Arginine	32-40	ornithine decarboxylase, structural 1	Mus musculus	93-116
25783604-9	2015	The Arg 180 and Leu 402 are crucial for these effects of the OAT molecule in development.	Arginine	4-7	ornithine aminotransferase	Xenopus laevis	61-64
25793367-8	2015	The drastic reduction in the levels of mature plastid tRNA-Phe(GAA) and tRNA-Arg(ACG) suggests that these two tRNA species limit plastid gene expression in the PRORP1 mutants and, hence, are causally responsible for the mutant phenotype.	Arginine	77-80	protein only RNase P catalytic subunit	Homo sapiens	160-166
25785610-3	2015	In these algorithms an occupation of the V3 positions 11 and 25, by one of the amino acids lysine (K) or arginine (R), is an indicator for CXCR4 usage.	Arginine	105-113	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
25660619-7	2015	Finally, intrathecal L-arginine alone did not affect the basal pain threshold, but it significantly decreased the antinociceptive response of emulsified sevoflurane against formalin injection and the suppressive effects of sevoflurane on formalin-induced Fos protein expression (P&lt;0.05).	Arginine	21-31	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	255-258
25893041-1	2015	The protein arginine methyltransferases PRMT7 and PRMT5, respectively, monomethylate and symmetrically dimethylate arginine side-chains of proteins involved in diverse cellular mechanisms, including chromatin-mediated control of gene transcription, splicing, and the RAS to ERK transduction cascade.	Arginine	12-20	protein arginine methyltransferase 7	Homo sapiens	40-45
25653279-10	2015	Collectively, our results indicate that arginine is essential for oTr1 cell proliferation and IFNT production via the NO/polyamine-TSC2-MTOR signaling pathways, particularly the pathway involving polyamine biosynthesis.	Arginine	40-48	TSC complex subunit 2	Homo sapiens	131-135
25277391-3	2015	Endothelial cell-specific Irs2 knockout (ETIrs2KO) mice exhibited impaired glucose-induced, arginine-induced, and glucagon-induced insulin secretion and showed glucose intolerance.	Arginine	92-100	insulin receptor substrate 2	Cricetulus griseus	26-30
26045834-1	2015	We conducted a case-control study to examine the role of genetic polymorphisms in XRCC1 at codons 194 (Arg&gt;Trp), 280 (Arg&gt;His) and 399 (Arg&gt;Gln) and XRCC3 at codon 241 (Thr&gt;Met) in the risk of TC.	Arginine	103-106	X-ray repair cross complementing 1	Homo sapiens	82-87
26101477-1	2015	OBJECTIVE: We conducted a case-control study to examine the role of XRCC1 codons 194 (Arg&gt;Trp), 280 (Arg&gt;His) and 399 (Arg&gt;Gln) polymorphisms in the risk of prostate cancer.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	68-73
26101477-3	2015	The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect XRCC1 codons 194 (Arg&gt;Trp), 280 (Arg&gt;His) and 399 (Arg&gt;Gln) polymorphisms.	Arginine	124-127	X-ray repair cross complementing 1	Homo sapiens	106-111
26101477-7	2015	CONCLUSION: Our results show an increased risk for prostate cancer in individuals with XRCC1 194 (Arg&gt;Trp) polymorphism, and a significant interaction between XRCC1 194 (Arg&gt;Trp) polymorphism and tobacco smoking, alcohol drinking and family history of cancer.	Arginine	98-101	X-ray repair cross complementing 1	Homo sapiens	87-92
26101477-7	2015	CONCLUSION: Our results show an increased risk for prostate cancer in individuals with XRCC1 194 (Arg&gt;Trp) polymorphism, and a significant interaction between XRCC1 194 (Arg&gt;Trp) polymorphism and tobacco smoking, alcohol drinking and family history of cancer.	Arginine	173-176	X-ray repair cross complementing 1	Homo sapiens	162-167
25550342-1	2015	I. cooperative effects of arginine and secreted phosphoprotein 1 on proliferation of ovine trophectoderm cells via activation of the PDK1-Akt/PKB-TSC2-MTORC1 signaling cascade.	Arginine	26-34	pyruvate dehydrogenase kinase 1	Homo sapiens	133-137
25550342-1	2015	I. cooperative effects of arginine and secreted phosphoprotein 1 on proliferation of ovine trophectoderm cells via activation of the PDK1-Akt/PKB-TSC2-MTORC1 signaling cascade.	Arginine	26-34	TSC complex subunit 2	Homo sapiens	146-150
25607844-5	2015	We determined that replacement of these residues by arginine enhances polyQ AR activity as a hormone-dependent transcriptional regulator.	Arginine	52-60	androgen receptor	Mus musculus	76-78
25447237-3	2015	It has been shown in cell culture that the nuclear import of FUS is mediated by transportin, which binds the PY-NLS and the last arginine/glycine/glycine-rich (RGG) domain of FUS.	Arginine	129-137	Transportin	Drosophila melanogaster	80-91
25310768-4	2015	Patients having XRCC1-399 Arg/Gln genotype or XRCC1-399 Gln/Gln genotype had a significantly higher risk of ESRD than those with XRCC1-399 Arg/Arg [odds ratio (OR): 2.48; 95% confidence intervals (CI): 1.36-4.52; p = 0.004 and OR: 4.05; 95% CI: 1.19-13.73; p = 0.03, respectively].	Arginine	26-29	X-ray repair cross complementing 1	Homo sapiens	16-21
25310768-6	2015	Combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with Asp/Asn or Asn/Asn genotypes of XPDAsp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Arginine	19-22	X-ray repair cross complementing 1	Homo sapiens	51-56
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Arginine	12-15	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Arginine	123-126	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25323582-7	2015	The ADH1B*47Arg allele was found to be associated with increased risk of HNC in Asians, with the pooled odds ratios (ORs) (Arg/Arg vs. Arg/His + His/His: OR = 2.35, 95% CI = 1.56-3.55, P &lt; 0.0001) in all eight studies.	Arginine	123-126	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-9
25392304-1	2015	Coactivator-associated arginine methyltransferase (CARM1/PRMT4)-mediated transcriptional coactivation and arginine methylation is known to regulate various tissue-specific differentiation events.	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	51-56
25392304-1	2015	Coactivator-associated arginine methyltransferase (CARM1/PRMT4)-mediated transcriptional coactivation and arginine methylation is known to regulate various tissue-specific differentiation events.	Arginine	23-31	coactivator associated arginine methyltransferase 1	Homo sapiens	57-62
25462345-5	2015	Substitution of non-conserved residues with arginines maintained antiviral activity and HSP70 binding and dispensed with polyarginine tag for cellular entry.	Arginine	44-53	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
25961037-1	2015	We investigated the effect of the hypertrophic cardiomyopathy-linked R21C (arginine to cysteine) mutation in human cardiac troponin I (cTnI) on the contractile properties and myofilament protein phosphorylation in papillary muscle preparations from left (LV) and right (RV) ventricles of homozygous R21C(+/+) knock-in mice.	Arginine	75-83	troponin I3, cardiac type	Homo sapiens	115-133
25961037-1	2015	We investigated the effect of the hypertrophic cardiomyopathy-linked R21C (arginine to cysteine) mutation in human cardiac troponin I (cTnI) on the contractile properties and myofilament protein phosphorylation in papillary muscle preparations from left (LV) and right (RV) ventricles of homozygous R21C(+/+) knock-in mice.	Arginine	75-83	troponin I3, cardiac type	Homo sapiens	135-139
26406958-7	2015	RESULTS: RAD51 135C and XRCC1 Arg allele are associated with ovarian carcinoma [OR (95% CI): 2.54 (1.22-5.29) for C vs. G; 2.64 (1.53-4.55) for Arg vs. Gln].	Arginine	30-33	X-ray repair cross complementing 1	Homo sapiens	24-29
26260685-3	2015	Interestingly, in cell-based studies CREBBP activity is modulated by post-translational modifications such as methylation on arginine residues which is catalyzed by coactivator-associated arginine methyltransferase 1 (CARM1).	Arginine	125-133	crebbp	Danio rerio	37-43
25349251-5	2015	Mass spectrometric analysis revealed that both acyl and desacyl ghrelin were hydrolyzed at the peptide bond between Arg(15) and Lys(16), generating an N-terminal peptide consisting of the first 15 residues.	Arginine	116-119	ghrelin and obestatin prepropeptide	Bos taurus	64-71
26576438-2	2015	Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand beta1 and the beginning of strand beta2, respectively.	Arginine	51-60	arginase type II	Mus musculus	10-15
26576438-2	2015	Arg-1 and Arg-2 substitute four positively charged arginines for segments that in structural models of amylin fibrils form the end of strand beta1 and the beginning of strand beta2, respectively.	Arginine	51-60	hemoglobin, beta adult minor chain	Mus musculus	175-180
25810899-2	2014	We previously identified that TLS was associated with protein arginine methyltransferase 1 (PRMT1), and four arginine residues within TLS (R216, R218, R242 and R394) were consistently dimethylated.	Arginine	62-70	protein arginine methyltransferase 1	Homo sapiens	92-97
25810899-7	2014	2B12 was also validated GST tagged TLS with PRMT1 by in vitro arginine methylation assays.	Arginine	62-70	protein arginine methyltransferase 1	Homo sapiens	44-49
25348736-4	2014	Replacing two lysine residues, K639 and K673, within this region by arginine, increases the stability of the luciferase fusion protein as well as Ncoa3 protein.	Arginine	68-76	nuclear receptor coactivator 3	Mus musculus	146-151
25348736-5	2014	When these two lysine residues are mutated to arginine, the overall ubiquitination level of Ncoa3 decreases, indicating that lysine 639 and 673 are its ubiquitination sites.	Arginine	46-54	nuclear receptor coactivator 3	Mus musculus	92-97
25253739-9	2014	The arginine residue in the pre-helix loop of GDF9 homodimer may prevent the inhibition from its pro-domain or directly alter receptor binding, but this residue in GDF9 does not significantly affect the heterodimer activity, because of suggested conformational changes during heterodimer formation.	Arginine	4-12	growth differentiation factor 9	Homo sapiens	46-50
24940800-6	2014	A conversion of lysines to arginines at positions 1114 and 1224 of the intracellular tail of murine nephrin led to decreased stability of nephrin, decreased expression at the plasma membrane, and decreased PI3K/AKT signaling.	Arginine	27-36	nephrosis 1, nephrin	Mus musculus	100-107
24940800-6	2014	A conversion of lysines to arginines at positions 1114 and 1224 of the intracellular tail of murine nephrin led to decreased stability of nephrin, decreased expression at the plasma membrane, and decreased PI3K/AKT signaling.	Arginine	27-36	nephrosis 1, nephrin	Mus musculus	138-145
25127453-0	2014	Novel therapy for pyridoxine dependent epilepsy due to ALDH7A1 genetic defect: L-arginine supplementation alternative to lysine-restricted diet.	Arginine	79-89	aldehyde dehydrogenase 7 family member A1	Homo sapiens	55-62
25127453-4	2014	We hypothesized that L-arginine supplementation will decrease accumulation of alpha-AASA by competitive inhibition of lysine transport into the central nervous system and improve neurodevelopmental and neurocognitive functions in PDE-ALDH7A1.	Arginine	21-31	aldehyde dehydrogenase 7 family member A1	Homo sapiens	234-241
25127453-5	2014	METHODS: A 12-year-old male with PDE-ALDH7A1 was treated with l-arginine supplementation as an innovative therapy.	Arginine	62-72	aldehyde dehydrogenase 7 family member A1	Homo sapiens	37-44
25127453-11	2014	CONCLUSION: The short-term treatment outcome of this novel L-arginine supplementation therapy for PDE-ALDH7A1 was successful for biochemical and neurocognitive improvements.	Arginine	59-69	aldehyde dehydrogenase 7 family member A1	Homo sapiens	102-109
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	170-173	MDM2 proto-oncogene	Homo sapiens	64-68
25316267-4	2014	There were significant differences in the frequency of TP53 and MDM2 genotypes in EC patients-increased EC occurrence was observed with the presence of MDM2 G/G and TP53 Arg/Arg genotypes, while allele Pro of TP53 decreased cancer risk.	Arginine	174-177	MDM2 proto-oncogene	Homo sapiens	64-68
25116630-0	2014	Terminal sialic acids on CD44 N-glycans can block hyaluronan binding by forming competing intramolecular contacts with arginine sidechains.	Arginine	119-127	CD44 molecule (Indian blood group)	Homo sapiens	25-29
25386178-9	2014	Since both arginine metabolic pathways cross-inhibit each other on the level of the respective arginine break-down products and Th1 and Th2 lymphocytes can drive or amplify macrophage M1/M2 dichotomy via cytokine activation, this forms the basis of a self-sustaining M1/M2 polarization of the whole immune response.	Arginine	11-19	negative elongation factor complex member C/D	Homo sapiens	128-131
25193658-4	2014	Mutating several lysines of the gamma2IL into arginines makes the gamma2 subunit resistant to RNF34-induced degradation.	Arginine	46-55	ring finger protein 34	Rattus norvegicus	94-99
25181320-9	2014	The mRNA expression of mechanistic target of rapamycin (mTOR) complex 1 pathway genes (mTOR and RPS6KB1) and the anti-apoptosis gene Bcl-2 quadratically responded to increasing dietary Arg supplementation (P&lt; 0 05).	Arginine	185-188	ribosomal protein S6 kinase B1	Gallus gallus	96-103
25294169-8	2014	Considering RBPs are well-known mammalian PRMT substrates, our data suggest that arginine methylation via LmjPRMT7 may modulate RBP function during Leishmania spp.	Arginine	81-89	retinol binding protein 4	Homo sapiens	12-15
25274726-5	2014	Interestingly, several of the tumor-promoting functions of CtsZ were not dependent on its described catalytic activity but instead were mediated via the Arg-Gly-Asp (RGD) motif in the enzyme prodomain, which regulated interactions with integrins and the extracellular matrix.	Arginine	153-156	cathepsin Z	Homo sapiens	59-63
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	64-69
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	70-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	66-69
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	183-186	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	64-69
24096484-6	2014	Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.	Arginine	183-186	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	66-69
25184293-6	2014	Candidate gene sequencing identified a G&gt;C transversion at position 5731 of CACNA1C (rs374528680) predicting a glycine&gt;arginine substitution at residue 1911 (p.G1911R) of CaV1.2.	Arginine	125-133	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	79-86
25184293-6	2014	Candidate gene sequencing identified a G&gt;C transversion at position 5731 of CACNA1C (rs374528680) predicting a glycine&gt;arginine substitution at residue 1911 (p.G1911R) of CaV1.2.	Arginine	125-133	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	177-183
25007327-13	2014	Expression of a PEX3 mutant with substitution of all lysine and cysteine residues by arginine and alanine, respectively, also induces peroxisome ubiquitination and degradation, hence suggesting that ubiquitination of PEX3 is dispensable for pexophagy and an endogenous, unidentified peroxisomal protein is ubiquitinated on the peroxisomal membrane.	Arginine	85-93	peroxisomal biogenesis factor 3	Homo sapiens	16-20
25082513-1	2014	Structure-activity relationship studies of the cyclopentapeptide CXCR4 antagonists (cyclo(-l-/d-Arg(1)-Arg(2)-2-Nal(3)-Gly(4)-d-Tyr(5)-)) suggest that the l-/d-Arg(1)-Arg(2)-2-Nal(3) tripeptide sequence contained within these cyclopentapeptides serves as a recognition motif for peptidic CXCR4 antagonists.	Arginine	91-93	C-X-C motif chemokine receptor 4	Homo sapiens	65-70
25104024-6	2014	Mutation of an arginine in the RNA recognition motif abrogated in vivo binding and the effect on miRNA and pri-miRNA levels, indicating that AtGRP7 inhibits processing of these pri-miRNAs by direct binding.	Arginine	15-23	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	141-147
24929581-1	2014	PR-39 is a gene-encoded, proline-arginine-rich porcine antimicrobial peptide with multiple biological functions.	Arginine	33-41	antibacterial protein PR-39	Sus scrofa	0-5
25054323-0	2014	Arginine enhances osteoblastogenesis and inhibits adipogenesis through the regulation of Wnt and NFATc signaling in human mesenchymal stem cells.	Arginine	0-8	nuclear factor of activated T cells 1	Homo sapiens	97-102
25054323-6	2014	This effect was associated with increased expression of Wnt5a, and nuclear factor of activated T-cells (NFATc), and was abrogated by antagonists of Wnt and NFATc, which indicated a role of Wnt and NFATc signaling in the switch from adipogenesis to osteoblastogenesis induced by arginine.	Arginine	278-286	nuclear factor of activated T cells 1	Homo sapiens	104-109
25054323-6	2014	This effect was associated with increased expression of Wnt5a, and nuclear factor of activated T-cells (NFATc), and was abrogated by antagonists of Wnt and NFATc, which indicated a role of Wnt and NFATc signaling in the switch from adipogenesis to osteoblastogenesis induced by arginine.	Arginine	278-286	nuclear factor of activated T cells 1	Homo sapiens	156-161
25054323-6	2014	This effect was associated with increased expression of Wnt5a, and nuclear factor of activated T-cells (NFATc), and was abrogated by antagonists of Wnt and NFATc, which indicated a role of Wnt and NFATc signaling in the switch from adipogenesis to osteoblastogenesis induced by arginine.	Arginine	278-286	nuclear factor of activated T cells 1	Homo sapiens	156-161
25054323-7	2014	In conclusion, this is the first report of the dual action of arginine in promoting osteogenesis and inhibiting adipocyte formation through involving Wnt5a and NFATc signaling pathway.	Arginine	62-70	nuclear factor of activated T cells 1	Homo sapiens	160-165
25034608-8	2014	The Asp-Phe-Gly (DFG) and His-Arg-Asp (HRD) conserved kinase motif analysis showed the importance of these motifs in IRAK4 kinase activation.	Arginine	30-33	interleukin 1 receptor associated kinase 4	Homo sapiens	117-122
25024628-11	2014	The XRCC1 399 Arg/Gln genotype was associated with a decreased risk of CRC among smokers and drinkers (OR = 0.289, 95%CI: 0.152-0.548, P &lt; 0.001, and OR = 0.327, 95%CI: 0.158-0.673, P &lt; 0.05, respectively).	Arginine	14-17	X-ray repair cross complementing 1	Homo sapiens	4-9
24891505-1	2014	The closely related Abl family kinases, Arg and Abl, play important non-redundant roles in the regulation of cell morphogenesis and motility.	Arginine	40-43	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	20-23
24891505-4	2014	We report that the Arg Src homology (SH) 2 domain binds two specific phosphotyrosines on cortactin, a known Abl/Arg substrate, with over 10-fold higher affinity than the Abl SH2 domain.	Arginine	19-22	cortactin	Homo sapiens	89-98
24891505-4	2014	We report that the Arg Src homology (SH) 2 domain binds two specific phosphotyrosines on cortactin, a known Abl/Arg substrate, with over 10-fold higher affinity than the Abl SH2 domain.	Arginine	19-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	108-111
24891505-4	2014	We report that the Arg Src homology (SH) 2 domain binds two specific phosphotyrosines on cortactin, a known Abl/Arg substrate, with over 10-fold higher affinity than the Abl SH2 domain.	Arginine	112-115	cortactin	Homo sapiens	89-98
24891505-5	2014	We show that this significant affinity difference is due to the substitution of arginine 161 and serine 187 in Abl to leucine 207 and threonine 233 in Arg, respectively.	Arginine	80-88	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	111-114
24891505-6	2014	We constructed Abl SH2 domains with R161L and S187T mutations alone and in combination and find that these substitutions are sufficient to convert the low affinity Abl SH2 domain to a higher affinity "Arg-like" SH2 domain in binding to a phospho-cortactin peptide.	Arginine	201-204	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	15-18
24891505-6	2014	We constructed Abl SH2 domains with R161L and S187T mutations alone and in combination and find that these substitutions are sufficient to convert the low affinity Abl SH2 domain to a higher affinity "Arg-like" SH2 domain in binding to a phospho-cortactin peptide.	Arginine	201-204	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	164-167
24891505-6	2014	We constructed Abl SH2 domains with R161L and S187T mutations alone and in combination and find that these substitutions are sufficient to convert the low affinity Abl SH2 domain to a higher affinity "Arg-like" SH2 domain in binding to a phospho-cortactin peptide.	Arginine	201-204	cortactin	Homo sapiens	246-255
24891505-7	2014	We crystallized the Arg SH2 domain for structural comparison to existing crystal structures of the Abl SH2 domain.	Arginine	20-23	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	99-102
24891505-9	2014	Finally, we expressed Arg containing an "Abl-like" low affinity mutant Arg SH2 domain (L207R/T233S) and find that this mutant, although properly localized to the cell periphery, does not support wild type levels of cell edge protrusion.	Arginine	22-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	41-44
24891505-9	2014	Finally, we expressed Arg containing an "Abl-like" low affinity mutant Arg SH2 domain (L207R/T233S) and find that this mutant, although properly localized to the cell periphery, does not support wild type levels of cell edge protrusion.	Arginine	71-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	41-44
25108327-7	2014	The Arg-Gua pairs have the greatest stability and are also most frequently observed.	Arginine	4-7	DExD-box helicase 21	Homo sapiens	8-11
24627544-7	2014	Use of MAO-SLC7A1 knockdown in conceptuses decreased arginine transport (73%, P&lt;0.01), the abundance of ornithine decarboxylase, and nitric oxide synthase (NOS3) proteins, arginine-related amino acids [citrulline (76%, P&lt;0.05) and ornithine (40%, P&lt;0.05)], and polyamines, which likely accounts for their retarded development.	Arginine	53-61	solute carrier family 7 member 1	Homo sapiens	11-17
24627544-7	2014	Use of MAO-SLC7A1 knockdown in conceptuses decreased arginine transport (73%, P&lt;0.01), the abundance of ornithine decarboxylase, and nitric oxide synthase (NOS3) proteins, arginine-related amino acids [citrulline (76%, P&lt;0.05) and ornithine (40%, P&lt;0.05)], and polyamines, which likely accounts for their retarded development.	Arginine	175-183	solute carrier family 7 member 1	Homo sapiens	11-17
24627544-9	2014	Collectively, SLC7A1 is the key transporter of arginine by conceptus Tr, and arginine is essential for conceptus survival and development.-Wang, X., Frank, J. W., Little, D. R., Dunlap, K. A., Satterfield, M. C., Burghardt, R. C., Hansen, T. R., Wu, G., and Bazer, F. W. Functional role of arginine during the peri-implantation period of pregnancy.	Arginine	47-55	solute carrier family 7 member 1	Homo sapiens	14-20
24807905-6	2014	NME7 interacts with the gammaTuRC through both A and B domains, with Arg-322 in domain B being crucial to the binding.	Arginine	69-72	NME/NM23 family member 7	Homo sapiens	0-4
24901643-8	2014	The N-terminal amino acid sequence CDD which is conserved between Kv2 and KvS subunits appeared to be a key determinant since charge reversals with arginine substitutions abolished the interaction between the N-terminus of Kv2.1 and the C-terminus of both Kv2.1 and Kv6.4.	Arginine	148-156	potassium voltage-gated channel subfamily B member 1	Homo sapiens	223-228
24901643-8	2014	The N-terminal amino acid sequence CDD which is conserved between Kv2 and KvS subunits appeared to be a key determinant since charge reversals with arginine substitutions abolished the interaction between the N-terminus of Kv2.1 and the C-terminus of both Kv2.1 and Kv6.4.	Arginine	148-156	potassium voltage-gated channel subfamily B member 1	Homo sapiens	256-261
24412328-6	2014	Substantial retardation of enzyme activity was observed toward Arg-MCA and substitution with Glu caused complete loss of enzymatic activity of APB.	Arginine	63-66	arginyl aminopeptidase	Homo sapiens	143-146
24753255-6	2014	Furthermore, NF-kappaB p65, a critical driver of TNF-alpha-mediated CXCL10 induction, was determined to be methylated at arginine residues.	Arginine	121-129	C-X-C motif chemokine ligand 10	Homo sapiens	68-74
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Arginine	69-72	C-X-C motif chemokine ligand 10	Homo sapiens	124-130
24753255-9	2014	Expression of Arg-to-Lys point mutants of p65 demonstrated that both Arg-30 and Arg-35 must be dimethylated to achieve full CXCL10 expression.	Arginine	69-72	C-X-C motif chemokine ligand 10	Homo sapiens	124-130
24583231-9	2014	Here we confirm that mutating the putatively sumoylated lysine (K10) of the Rhesus macaque TRIM5alpha (TRIM5alphaRh) to an arginine has only a small effect on restriction.	Arginine	123-131	tripartite motif containing 5	Macaca mulatta	91-101
24735539-6	2014	We found that the positively charged arginine at position 136 was predicted to be important for binding to the negatively charged heparan-sulfate proteoglycan (HSPG).	Arginine	37-45	CD44 molecule (Indian blood group)	Homo sapiens	130-158
24735539-6	2014	We found that the positively charged arginine at position 136 was predicted to be important for binding to the negatively charged heparan-sulfate proteoglycan (HSPG).	Arginine	37-45	CD44 molecule (Indian blood group)	Homo sapiens	160-164
24816101-6	2014	However, a highly conserved lysine in O-sulfatases is replaced in SGSH by an arginine (Arg282) that is positioned to bind the N-linked sulfate substrate.	Arginine	77-85	N-sulfoglucosamine sulfohydrolase	Homo sapiens	66-70
24782176-6	2014	RESULTS: Among the 87 identified studies examining genetic associations with MTX efficacy and toxicity, the reduced folate carrier 1 gene (RFC1) variant 80G&gt;A (Arg(27) His, rs1051266) was selected for random-effects meta-analysis.	Arginine	163-166	replication factor C subunit 1	Homo sapiens	139-143
24553751-6	2014	tmm-6 mutation took a base transition from guanine to adenine in 463 of TMM and changed a glycine (Gly) to an arginine (Arg) in position 155 of the protein.	Arginine	110-118	Leucine-rich repeat (LRR) family protein	Arabidopsis thaliana	0-3
24553751-6	2014	tmm-6 mutation took a base transition from guanine to adenine in 463 of TMM and changed a glycine (Gly) to an arginine (Arg) in position 155 of the protein.	Arginine	120-123	Leucine-rich repeat (LRR) family protein	Arabidopsis thaliana	0-3
24788778-9	2014	Among groups, the expression of CSN1S1, CSN1S2, CSN2, CSN3, JAK2, STAT5, mTOR and S6K gene was highest with Arg 2X (P&lt;0.05); the reverse was true for 4EBP1 gene, with the lowest expression in this group (P&lt;0.05).	Arginine	108-111	alpha-S2-casein	Bos taurus	40-46
24721747-1	2014	Methylation of N-terminal arginines of the shelterin component TRF2 is important for cellular proliferation.	Arginine	26-35	telomeric repeat binding factor 2	Homo sapiens	63-67
24100601-6	2014	RESULTS: Long-term dietary L-arginine supplementation increases VIP and NOSs immunoexpression at room temperature while at cold increases the endothelial NOS, inducible NOS and VIP but decrease neuronal NOS in rat small intestine.	Arginine	27-37	nitric oxide synthase 3	Rattus norvegicus	142-157
24600035-5	2014	A highly conserved residue Arg(97) in the CDR3alpha loop played a major role in recognition of peptide and MHC to form a stabilizing ball-and-socket interaction with the MHC and peptide, contributing to the selection of the public TCR clonotype.	Arginine	27-30	major histocompatibility complex, class I, C	Homo sapiens	107-110
24600035-5	2014	A highly conserved residue Arg(97) in the CDR3alpha loop played a major role in recognition of peptide and MHC to form a stabilizing ball-and-socket interaction with the MHC and peptide, contributing to the selection of the public TCR clonotype.	Arginine	27-30	major histocompatibility complex, class I, C	Homo sapiens	170-173
24531000-3	2014	A Ser-to-Arg mutation at site 163 (S163R) in C1QTNF5 is known to cause late-onset retinal macular degeneration (L-ORMD).	Arginine	9-12	C1q and TNF related 5	Homo sapiens	45-52
24478314-2	2014	As the major arginine methylation enzyme, protein arginine methyltransferase 1 (PRMT1) strictly generates monomethylarginine and asymmetric dimethylarginine (ADMA), but not symmetric dimethylarginine (SDMA).	Arginine	13-21	protein arginine methyltransferase 1	Homo sapiens	42-78
24478314-2	2014	As the major arginine methylation enzyme, protein arginine methyltransferase 1 (PRMT1) strictly generates monomethylarginine and asymmetric dimethylarginine (ADMA), but not symmetric dimethylarginine (SDMA).	Arginine	13-21	protein arginine methyltransferase 1	Homo sapiens	80-85
24676404-5	2014	Two amino acid insertions between positions 13 and 14, as well as arginine substitution at position 11 or 16 (IG insertion and P16R mutation or MG insertion and S11R mutation), conferred the chimeric viruses CXCR4-tropic features, which were same as subtype C X4 viruses.	Arginine	66-74	C-X-C motif chemokine receptor 4	Homo sapiens	208-213
24643009-6	2014	The gating mechanism in the inward-facing state of EAAT3 is found to be different from that of GltPh, which is traced to the relocation of an arginine residue from the HP1 segment in GltPh to the TM8 segment in EAAT3.	Arginine	142-150	tetraspanin 16	Homo sapiens	196-199
24292556-1	2014	Serine/arginine-rich splicing factor 3 (SRSF3), a member of the serine/arginine (SR)-rich family of proteins, regulates both alternative splicing of pre-mRNA and export of mature mRNA from the nucleus.	Arginine	7-15	serine and arginine rich splicing factor 3	Homo sapiens	40-45
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	59-67	adrenoceptor beta 2	Homo sapiens	105-132
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	59-67	adrenoceptor beta 2	Homo sapiens	134-139
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	71-79	adrenoceptor beta 2	Homo sapiens	105-132
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	71-79	adrenoceptor beta 2	Homo sapiens	134-139
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	71-79	adrenoceptor beta 2	Homo sapiens	105-132
24201779-8	2014	Conversely, an increased risk was observed for the glycine/arginine or arginine/arginine genotype of the adrenoceptor beta2, surface (ADRB2) gene rs1042713 as compared with the glycine/glycine genotype (odds ratio, 1.52 [95% confidence interval, 1.01-2.31]).	Arginine	71-79	adrenoceptor beta 2	Homo sapiens	134-139
24449914-4	2014	A constellation of charged residues on and around the arginine-rich helix of Tnpo3 HEAT repeat 15 engage the phosphorylated RS domain and are critical for the recognition and nuclear import of ASF/SF2.	Arginine	54-62	serine and arginine rich splicing factor 1	Homo sapiens	193-200
24361899-9	2014	The results provide evidence that Ang-(1-7) most likely induces peripheral antinociceptive effects via the L-arginine/NO/cGMP pathway and KATP+ pathway activation.	Arginine	107-117	angiogenin	Rattus norvegicus	34-42
24327170-0	2014	Abomasal infusion of arginine stimulates SCD and C/EBPss gene expression, and decreases CPT1ss gene expression in bovine adipose tissue independent of conjugated linoleic acid.	Arginine	21-29	stearoyl-CoA desaturase	Bos taurus	41-44
24327170-1	2014	Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA).	Arginine	86-94	stearoyl-CoA desaturase	Bos taurus	140-163
24327170-1	2014	Based on previous research with bovine peadipocytes, we hypothesized that infusion of arginine into the abomasum of Angus steers stimulates stearoyl-CoA desaturase (SCD) gene expression in bovine subcutaneous (s.c.) adipose tissue, and that this would be attenuated by conjugated linoleic acid (CLA).	Arginine	86-94	stearoyl-CoA desaturase	Bos taurus	165-168
24327170-8	2014	By day 28, C/EBPbeta and SCD gene expression was higher, and CPT1beta gene expression was lower, in s.c. adipose tissue of steers infused with arginine than in steers infused with alanine (+-CLA) (P = 0.05).	Arginine	143-151	stearoyl-CoA desaturase	Bos taurus	25-28
24465614-5	2014	NAGS (EC 2.3.1.1) catalyzes the formation of N-acetylglutamate from glutamate and acetyl coenzyme A and in zebrafish is partially inhibited by L-arginine.	Arginine	143-153	isovaleryl-CoA dehydrogenase	Danio rerio	89-99
24465614-11	2014	In the presence of L-arginine the apparent Vmax of zfNAGS-M and zfNAGS-C decreased, their Km(app) for acetyl coenzyme A increased while the Km(app) for glutamate remained unchanged.	Arginine	19-29	isovaleryl-CoA dehydrogenase	Danio rerio	109-119
24361105-2	2014	Here, we show that Ubr1, the ubiquitin ligase of the Arg/N-end rule pathway, recognizes unacetylated N-terminal methionine if it is followed by a hydrophobic residue.	Arginine	53-56	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	19-23
24361105-3	2014	This capability of Ubr1 expands the range of substrates that can be targeted for degradation by the Arg/N-end rule pathway because virtually all nascent cellular proteins bear N-terminal methionine.	Arginine	100-103	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	19-23
24275664-7	2014	Mouse CD163 resisted endotoxin- and phorbol ester-induced shedding, and ex vivo analysis of knock-in of the Arg-Ser-Ser-Arg sequence in mouse CD163 revealed a receptor shedding comparable with that of human CD163.	Arginine	120-123	CD163 molecule	Homo sapiens	142-147
24366945-5	2014	In addition to E2 dimerization, we show that a highly conserved arginine residue in the donor Ube2g2 senses the presence of an aspartate in the acceptor ubiquitin to position only Lys48 of ubiquitin in proximity to the donor E2 active site.	Arginine	64-72	ubiquitin conjugating enzyme E2 G2	Homo sapiens	94-100
24140009-3	2014	As the signature pattern conserved among voltage-gated channels and voltage-sensing phosphatase, Hv1 has multiple arginines intervened by two hydrophobic residues on the fourth transmembrane segment, S4.	Arginine	114-123	hepatitis virus (MHV-2) susceptibility	Mus musculus	97-100
24140009-8	2014	Only the first arginine on S4 (R1: R201) was inaccessible by NEM and AMS in mHv1.	Arginine	15-23	hepatitis virus (MHV-2) susceptibility	Mus musculus	76-80
24987688-4	2014	In fact, a significant drop in viability of arginine-starved SKOV3 cells was observed when autophagy was inhibited by either coadministration of chloroquine or transcriptional silencing of the essential autophagy protein BECLIN 1.	Arginine	44-52	beclin 1	Homo sapiens	221-229
24971336-5	2014	RESULTS: The frequency of Arg/Gln genotype of the XRCC1 Arg399Gln polymorphism was significantly lower in SLE patients than controls.	Arginine	26-29	X-ray repair cross complementing 1	Homo sapiens	50-55
24971336-9	2014	CONCLUSION: These findings suggest that XRCC1 399 Arg/Gln heterozygous genotype plays a protective role in SLE susceptibility.	Arginine	50-53	X-ray repair cross complementing 1	Homo sapiens	40-45
23860860-4	2014	Toward this end, this study investigates the influence of charge and hydrophobicity on the activity of tryptophan and arginine rich decamer peptides engineered from a salt resistant human beta-defensin-28 variant.	Arginine	118-126	defensin beta 128	Homo sapiens	188-204
24452287-3	2014	Here we show that the two shuttling serine/arginine (SR)-proteins Gbp2 and Hrb1 are key surveillance factors for the selective export of spliced mRNAs in yeast.	Arginine	43-51	mRNA-binding protein	Saccharomyces cerevisiae S288C	75-79
24154564-3	2013	Indeed, it is well established that alphavbeta3 integrin plays a key role in tumor angiogenesis acting like a receptor for the extracellular matrix proteins like vitronectin, fibronectin through the arginine-glycine-aspartic acid (RGD) sequence.	Arginine	199-207	vitronectin	Homo sapiens	162-173
23990365-3	2013	Here, we initially performed mutagenesis analysis and identified a key residue (Arg(582)) required for activation of GYS2 by G6P.	Arginine	80-83	glycogen synthase 2	Mus musculus	117-121
24100041-5	2013	Double knockdown of the serine/arginine-rich (SR)-like proteins BCLAF1 and THRAP3 by siRNA resulted in a decrease in the nuclear speckle localization of WTAP, whereas the nuclear speckles were intact.	Arginine	31-39	BCL2 associated transcription factor 1	Homo sapiens	64-70
24223914-10	2013	Small inhibitory RNA (siRNA)-mediated inhibition of Arg II in MDA-MB-468 and HCC-1806 cells led to significant inhibition of both the mSHMT gene and protein expression.	Arginine	52-55	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	134-139
24223914-11	2013	As mSHMT is a key player in folate metabolism, our data provides a novel link between arginine and folate metabolism in human breast cancer, both of which are critical for tumor cell proliferation.	Arginine	86-94	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	3-8
24014022-6	2013	The BR competes with FXa for binding to FV(a), and limited proteolysis of the B-domain, specifically at Arg(1545), ablates BR binding to promote high affinity association between FVa and FXa.	Arginine	104-107	coagulation factor X	Homo sapiens	187-190
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 47 member 1	Homo sapiens	217-256
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 47 member 1	Homo sapiens	258-263
23864433-2	2013	Our aim was to investigate if ADMA and/or L-arginine are substrates of the human cationic amino acid transporters 2A (CAT2A, SLC7A2A) and 2B (CAT2B, SLC7A2B), the organic cation transporter 2 (OCT2, SLC22A2), and the multidrug and toxin extrusion protein 1 (MATE1, SLC47A1).	Arginine	42-52	solute carrier family 47 member 1	Homo sapiens	265-272
23864433-9	2013	ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1.	Arginine	9-19	solute carrier family 47 member 1	Homo sapiens	67-72
23796823-6	2013	In experiment 2, feeding the 4% ARG diet significantly increased the amplitude of pulsatile plasma GH levels and also significantly increased IGF-I mRNA in liver and muscle, (at 2h PP) and plasma IGF-I levels (at 6h PP).	Arginine	32-35	insulin-like growth factor I	Ictalurus punctatus	142-147
23796823-6	2013	In experiment 2, feeding the 4% ARG diet significantly increased the amplitude of pulsatile plasma GH levels and also significantly increased IGF-I mRNA in liver and muscle, (at 2h PP) and plasma IGF-I levels (at 6h PP).	Arginine	32-35	insulin-like growth factor I	Ictalurus punctatus	196-201
23796823-8	2013	Additionally, expressed and secreted IGF-I exhibited discernible patterns which closely correlate with ARG-induced growth effects in catfish.	Arginine	103-106	insulin-like growth factor I	Ictalurus punctatus	37-42
23146907-3	2013	Activation of Src, Erk1/2, Abl and Arg downstream of epidermal growth factor receptor (EGFR) modulates invadopodia activity through phosphorylation of the actin regulatory protein cortactin.	Arginine	35-38	cortactin	Homo sapiens	180-189
23146907-4	2013	In MDA-MB-231 breast cancer cells, Abl and Arg function downstream of Src to phosphorylate cortactin, promoting invadopodia ECM degradation activity and thus assigning a pro-invasive role for Ableson kinases.	Arginine	43-46	cortactin	Homo sapiens	91-100
24422407-8	2013	RESULT: Low, middle and high doses of TG and L-arg preventive administration could significantly reduce RVSP, RVHI, RVW/BW and ANF mRNA expressions (P &lt; 0.	Arginine	45-50	natriuretic peptide A	Rattus norvegicus	127-130
23980157-4	2013	Using mass spectrometry, we find that one of these core residues, arginine 42 of histone H3 (H3R42), is dimethylated in mammalian cells by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo, and we demonstrate that methylation of H3R42 stimulates transcription in vitro from chromatinized templates.	Arginine	66-74	coactivator associated arginine methyltransferase 1	Homo sapiens	204-209
23673479-6	2013	Female carrying XPC Gln/Gln, XPC Lys/Gln+Gln/Gln and XRCC1 Arg/Gln, XRCC1 Arg/Gln+Gln/Gln genotypes had significantly increased risk of lung cancer corresponding to OR = 2.06; p = 0.04, OR = 1.66; p = 0.04 and OR = 1.62; p = 0.04, OR = 1.69; p = 0.02 respectively.	Arginine	59-62	X-ray repair cross complementing 1	Homo sapiens	53-58
23673479-6	2013	Female carrying XPC Gln/Gln, XPC Lys/Gln+Gln/Gln and XRCC1 Arg/Gln, XRCC1 Arg/Gln+Gln/Gln genotypes had significantly increased risk of lung cancer corresponding to OR = 2.06; p = 0.04, OR = 1.66; p = 0.04 and OR = 1.62; p = 0.04, OR = 1.69; p = 0.02 respectively.	Arginine	59-62	X-ray repair cross complementing 1	Homo sapiens	68-73
23673479-6	2013	Female carrying XPC Gln/Gln, XPC Lys/Gln+Gln/Gln and XRCC1 Arg/Gln, XRCC1 Arg/Gln+Gln/Gln genotypes had significantly increased risk of lung cancer corresponding to OR = 2.06; p = 0.04, OR = 1.66; p = 0.04 and OR = 1.62; p = 0.04, OR = 1.69; p = 0.02 respectively.	Arginine	74-77	X-ray repair cross complementing 1	Homo sapiens	53-58
23673479-6	2013	Female carrying XPC Gln/Gln, XPC Lys/Gln+Gln/Gln and XRCC1 Arg/Gln, XRCC1 Arg/Gln+Gln/Gln genotypes had significantly increased risk of lung cancer corresponding to OR = 2.06; p = 0.04, OR = 1.66; p = 0.04 and OR = 1.62; p = 0.04, OR = 1.69; p = 0.02 respectively.	Arginine	74-77	X-ray repair cross complementing 1	Homo sapiens	68-73
23707382-2	2013	Prior studies have shown that cytoplasmic-nuclear translocalization of the SR protein SRSF1 is regulated by multisite phosphorylation of a long Arg-Ser repeat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation of a shorter Arg-Ser repeat along with several Ser-Pro dipeptides in the C-terminus of the RS domain.	Arginine	144-147	serine and arginine rich splicing factor 1	Homo sapiens	86-91
23707382-2	2013	Prior studies have shown that cytoplasmic-nuclear translocalization of the SR protein SRSF1 is regulated by multisite phosphorylation of a long Arg-Ser repeat in the N-terminus of the RS domain while subnuclear localization is controlled by phosphorylation of a shorter Arg-Ser repeat along with several Ser-Pro dipeptides in the C-terminus of the RS domain.	Arginine	270-273	serine and arginine rich splicing factor 1	Homo sapiens	86-91
23707382-3	2013	To better understand how these two kinases partition Arg-Ser versus Ser-Pro specificities, we monitored the phosphorylation of SRSF1 by CLK1 and SRPK1.	Arginine	53-56	serine and arginine rich splicing factor 1	Homo sapiens	127-132
23836892-7	2013	Another arginine residue in the PSST subunit is hydroxylated and probably lies near to the quinone.	Arginine	8-16	NADH:ubiquinone oxidoreductase core subunit S7	Homo sapiens	32-36
23850694-1	2013	Maricaulis maris N-acetylglutamate synthase/kinase (mmNAGS/K) catalyzes the first two steps in L-arginine biosynthesis and has a high degree of sequence and structural homology to human N-acetylglutamate synthase, a regulator of the urea cycle.	Arginine	95-105	N-acetylglutamate synthase	Homo sapiens	17-43
23850694-1	2013	Maricaulis maris N-acetylglutamate synthase/kinase (mmNAGS/K) catalyzes the first two steps in L-arginine biosynthesis and has a high degree of sequence and structural homology to human N-acetylglutamate synthase, a regulator of the urea cycle.	Arginine	95-105	N-acetylglutamate synthase	Homo sapiens	186-212
23850694-2	2013	The synthase activity of both mmNAGS/K and human NAGS are regulated by L-arginine, although L-arginine is an allosteric inhibitor of mmNAGS/K, but an activator of human NAGS.	Arginine	71-81	N-acetylglutamate synthase	Homo sapiens	32-36
23850694-2	2013	The synthase activity of both mmNAGS/K and human NAGS are regulated by L-arginine, although L-arginine is an allosteric inhibitor of mmNAGS/K, but an activator of human NAGS.	Arginine	71-81	N-acetylglutamate synthase	Homo sapiens	49-53
23850694-2	2013	The synthase activity of both mmNAGS/K and human NAGS are regulated by L-arginine, although L-arginine is an allosteric inhibitor of mmNAGS/K, but an activator of human NAGS.	Arginine	92-102	N-acetylglutamate synthase	Homo sapiens	32-36
23850694-2	2013	The synthase activity of both mmNAGS/K and human NAGS are regulated by L-arginine, although L-arginine is an allosteric inhibitor of mmNAGS/K, but an activator of human NAGS.	Arginine	92-102	N-acetylglutamate synthase	Homo sapiens	49-53
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	258-261	X-ray repair cross complementing 1	Homo sapiens	145-150
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	258-261	X-ray repair cross complementing 1	Homo sapiens	145-150
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	262-265	X-ray repair cross complementing 1	Homo sapiens	145-150
23894404-7	2013	In the combined analysis of the XRCC1 and XPD genes patients with stage II/III tumors, the poorest OS occurred in colon cancer patients with the XRCC1 Gln and XPD Gln allelic variants (HR  =2.60, 95% CI  =1.19-5.71) and rectal cancer patients with the XRCC1 Arg/Arg and XPD Gln allelic variants (HR  =2.77, 95% CI  =1.25-6.17).	Arginine	262-265	X-ray repair cross complementing 1	Homo sapiens	145-150
23841815-1	2013	BACKGROUND: The rs41318021 polymorphism in the SLC7A1 gene affects endothelial NO production through changes in L-arginine transport.	Arginine	112-122	solute carrier family 7 member 1	Homo sapiens	47-53
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Arginine	41-51	arginase 2	Homo sapiens	24-28
23847624-5	2013	The arginases (Arg1 and Arg2) metabolize l-arginine to generate l-ornithine and urea and increased expression of arginase has been proposed as a mechanism of reduced eNOS activity secondary to the depletion of l-arginine.	Arginine	210-220	arginase 2	Homo sapiens	24-28
23785733-5	2004	Extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) contain a tripeptide sequence consisting of Arg-Gly-Asp (RGD), which binds to a variety of integrins, including alphavbeta3.	Arginine	123-126	vitronectin	Mus musculus	31-42
23436070-2	2013	((R)-1-(2-chlorophenyl)-N-[(11)C]-methyl-N-(1-methylpropyl)-3-isoquinoline caboxamide ([(11)C]-(R)-PK11195) has been widely used for PET imaging of TSPO and, despite its low specific-to-nondisplaceable binding ratio, increased TSPO binding has been shown in AD patients.	Arginine	2-3	translocator protein	Homo sapiens	148-152
23436070-2	2013	((R)-1-(2-chlorophenyl)-N-[(11)C]-methyl-N-(1-methylpropyl)-3-isoquinoline caboxamide ([(11)C]-(R)-PK11195) has been widely used for PET imaging of TSPO and, despite its low specific-to-nondisplaceable binding ratio, increased TSPO binding has been shown in AD patients.	Arginine	2-3	translocator protein	Homo sapiens	227-231
22904165-6	2013	Arg (0.5%) supplementation increased the numbers of IgA-secreting cells, CD8(+) and CD4(+) T cells in the ileum (P &lt; 0.05).	Arginine	0-3	CD4 molecule	Sus scrofa	84-87
23460752-0	2013	Arginine transport is impaired in C57Bl/6 mouse macrophages as a result of a deletion in the promoter of Slc7a2 (CAT2), and susceptibility to Leishmania infection is reduced.	Arginine	0-8	dominant cataract 2	Mus musculus	113-117
23785305-3	2013	A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit.	Arginine	15-18	BMS1, ribosome biogenesis factor	Mus musculus	78-82
23785305-3	2013	A heterozygous Arg-to-His missense mutation (p.R930H) in the ribosomal GTPase BMS1 is identified in ACC that is associated with a delay in 18S rRNA maturation, consistent with a role of BMS1 in processing of pre-rRNAs of the small ribosomal subunit.	Arginine	15-18	BMS1, ribosome biogenesis factor	Mus musculus	186-190
23599266-5	2013	The crystal structure of the alpha-TTP-PIPs complex revealed that the disease-related arginine residues interacted with phosphate groups of the PIPs and that the PIPs binding caused the lid of the alpha-tocopherol-binding pocket to open.	Arginine	86-94	alpha tocopherol transfer protein	Homo sapiens	29-38
23741301-5	2013	We identified two novel missense mutations in the SLC30A2/ZnT2 gene in a Japanese mother with low milk zinc concentrations (&gt;90% reduction) whose infant developed severe zinc deficiency; a T to C transition (c.454T&gt;C) at exon 4, which substitutes a tryptophan residue with an arginine residue (W152R), and a C to T transition (c.887C&gt;T) at exon 7, which substitutes a serine residue with a leucine residue (S296L).	Arginine	282-290	solute carrier family 30 member 2	Homo sapiens	50-57
23741301-5	2013	We identified two novel missense mutations in the SLC30A2/ZnT2 gene in a Japanese mother with low milk zinc concentrations (&gt;90% reduction) whose infant developed severe zinc deficiency; a T to C transition (c.454T&gt;C) at exon 4, which substitutes a tryptophan residue with an arginine residue (W152R), and a C to T transition (c.887C&gt;T) at exon 7, which substitutes a serine residue with a leucine residue (S296L).	Arginine	282-290	solute carrier family 30 member 2	Homo sapiens	58-62
23624934-0	2013	Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.	Arginine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
23624934-0	2013	Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.	Arginine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-74
23624934-4	2013	Moreover, RACO-1 is identified as a substrate of the arginine methyltransferase PRMT1, which methylates RACO-1 on two arginine residues.	Arginine	53-61	protein arginine methyltransferase 1	Homo sapiens	80-85
23624934-5	2013	Arginine methylation of RACO-1 promotes a conformational change that stabilises RACO-1 by facilitating K63-linked ubiquitin chain formation, and enables RACO-1 dimerisation and c-Jun interaction.	Arginine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	177-182
23624934-7	2013	These results demonstrate that arginine methylation of RACO-1 is required for efficient transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as an important regulator of c-Jun/AP-1 function.	Arginine	31-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
23624934-7	2013	These results demonstrate that arginine methylation of RACO-1 is required for efficient transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as an important regulator of c-Jun/AP-1 function.	Arginine	31-39	protein arginine methyltransferase 1	Homo sapiens	147-152
23624934-7	2013	These results demonstrate that arginine methylation of RACO-1 is required for efficient transcriptional activation by c-Jun/AP-1 and thus identify PRMT1 as an important regulator of c-Jun/AP-1 function.	Arginine	31-39	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	107-110	adrenoceptor beta 2	Homo sapiens	75-95
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	107-110	adrenoceptor beta 2	Homo sapiens	97-102
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	111-114	adrenoceptor beta 2	Homo sapiens	75-95
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	111-114	adrenoceptor beta 2	Homo sapiens	97-102
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	111-114	adrenoceptor beta 2	Homo sapiens	75-95
23613100-11	2013	Pharmacogenomic studies have shown that patients with polymorphisms of the beta2-adrenoreceptor (ADRB2; 16 Arg/Arg and 16 Arg/Gly) are particularly responsive to treatment with tiotropium.	Arginine	111-114	adrenoceptor beta 2	Homo sapiens	97-102
23596642-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
22857794-4	2013	METHODS: We genotyped rs2476601 (g.1858C&gt;T), a single nucleotide polymorphism encoding substitution of arginine for tryptophan in PTPN22 (R620W), in 193 patients with PAD and 148 control subjects from an Australian cohort.	Arginine	106-114	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	133-139
23295407-2	2013	We hypothesized that protein kinase C-alpha (PKC-alpha) is involved in the increases of L-arginine in melatonin-treated BDL rats.	Arginine	88-98	protein kinase C, alpha	Rattus norvegicus	45-54
23295407-9	2013	Melatonin additionally increased L-arginine concentrations in BDL liver, which is correlated with decreased PKC-alpha translocation.	Arginine	33-43	protein kinase C, alpha	Rattus norvegicus	108-117
23295407-12	2013	CONCLUSION: Melatonin inhibits PKC-alpha to increase cationic amino acid transporter-1 (CAT-1)-mediated L-arginine uptake in BDL liver, whereas it inhibits PKC-beta to reduce NADPH-dependent superoxide production.	Arginine	104-114	protein kinase C, alpha	Rattus norvegicus	31-40
24280230-6	2013	Argininosuccinate was found to be produced from arginine and fumarate by the reverse activity of the urea cycle enzyme argininosuccinate lyase (ASL), making these cells auxotrophic for arginine.	Arginine	48-56	argininosuccinate lyase	Mus musculus	119-142
24280230-6	2013	Argininosuccinate was found to be produced from arginine and fumarate by the reverse activity of the urea cycle enzyme argininosuccinate lyase (ASL), making these cells auxotrophic for arginine.	Arginine	185-193	argininosuccinate lyase	Mus musculus	119-142
23485969-9	2013	An arginine target of PRMT1 methylation protrudes directly into this convergence zone and sustains its integrity.	Arginine	3-11	protein arginine methyltransferase 1	Homo sapiens	22-27
23335559-6	2013	Mutation of Lys-5-57 to arginines prevented binding of the VCP-UBXD1 complex and, importantly, strongly reduced recruitment of VCP-UBXD1 to endocytic compartments.	Arginine	24-33	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	12-17
23395486-4	2013	We show that the arginine residues (R56, R60 and R132) which form the 14-3-3e ligand binding site are responsible for the binding of 14-3-3e to phosphorylated Ubinuclein-1.	Arginine	17-25	ubinuclein 1	Homo sapiens	159-171
23355523-5	2013	Disease-causing mutations were identified in three of the probands: a novel single-nucleotide deletion in both KLK4 alleles (g.6930delG; c.245delG; p.Gly82Alafs*87) that shifted the reading frame, a novel missense transition mutation in both MMP20 alleles (g.15390A&gt;G; c.611A&gt;G; p.His204Arg) that substituted arginine for an invariant histidine known to coordinate a structural zinc ion, and a previously described nonsense transition mutation in a single allele of FAM83H (c.1379G&gt;A; g.5663G&gt;A; p.W460*).	Arginine	315-323	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Mus musculus	111-115
22748806-8	2013	Arginine stimulated SCD gene expression, whereas CLA depressed SCD gene expression in adipocytes and myoblasts (P=.002).	Arginine	0-8	stearoyl-CoA desaturase	Bos taurus	20-23
23339388-1	2013	BACKGROUND AND AIM: Arginine is a nonessential amino acid for humans and mice because it can be synthesized from citrulline by argininosuccinate synthetase (ASS) and argininosuccinate lyase.	Arginine	20-28	argininosuccinate lyase	Mus musculus	166-189
23184394-3	2013	The biological function of this anaphylatoxin is regulated by carboxypeptidase B, a plasma protease that cleaves off the C-terminal arginine yielding C3a desArg, an inactive form.	Arginine	132-140	carboxypeptidase B1	Homo sapiens	62-80
23184394-3	2013	The biological function of this anaphylatoxin is regulated by carboxypeptidase B, a plasma protease that cleaves off the C-terminal arginine yielding C3a desArg, an inactive form.	Arginine	132-140	complement C3	Homo sapiens	150-153
23390665-0	2004	(99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2 (99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2, abbreviated as (99m)Tc-BN-A, is an analog of the bombesin (BN) peptide, which was synthesized by Liolios et al.	Arginine	20-24	gastrin releasing peptide	Homo sapiens	27-35
23390665-0	2004	(99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2 (99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2, abbreviated as (99m)Tc-BN-A, is an analog of the bombesin (BN) peptide, which was synthesized by Liolios et al.	Arginine	20-24	gastrin releasing peptide	Homo sapiens	73-81
23390665-0	2004	(99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2 (99m)Tc-Gly-Gly-Cys-(Arg)3-bombesin(2-14)-NH2, abbreviated as (99m)Tc-BN-A, is an analog of the bombesin (BN) peptide, which was synthesized by Liolios et al.	Arginine	20-24	gastrin releasing peptide	Homo sapiens	73-81
24040626-7	2013	The XRCC1 399 Arg/gln polymorphism showed a substantial smaller difference in allele frequencies between exposed and control subjects.	Arginine	14-17	X-ray repair cross complementing 1	Homo sapiens	4-9
23796541-0	2013	Cyclosporine attenuates arginine transport, in human endothelial cells, through modulation of cationic amino acid transporter-1.	Arginine	24-32	solute carrier family 7 member 1	Homo sapiens	94-127
23796541-6	2013	We hypothesize that CsA inhibits eNOS activity through modulation of its selective arginine supplier CAT-1.	Arginine	83-91	solute carrier family 7 member 1	Homo sapiens	101-106
23796541-11	2013	CsA significantly decreased the abundance of CAT-1 protein, an effect that was attenuated by L-arginine.	Arginine	93-103	solute carrier family 7 member 1	Homo sapiens	45-50
24377605-5	2013	RESULTS: Genotype frequencies of XRCC1 Arg399Gln observed in controls were 34.2%, 42.5% and 23.3% for GG (Arg/Arg), GA (Arg/Gln), AA( Gln/Gln), respectively, and 28.3%, 66.7% and 5% in cases, with an odds ratio (OR)=5.7 and 95% confidence interval (CI) =2.3-14.1 (p=0.0001).	Arginine	39-42	X-ray repair cross complementing 1	Homo sapiens	33-38
24377605-5	2013	RESULTS: Genotype frequencies of XRCC1 Arg399Gln observed in controls were 34.2%, 42.5% and 23.3% for GG (Arg/Arg), GA (Arg/Gln), AA( Gln/Gln), respectively, and 28.3%, 66.7% and 5% in cases, with an odds ratio (OR)=5.7 and 95% confidence interval (CI) =2.3-14.1 (p=0.0001).	Arginine	106-109	X-ray repair cross complementing 1	Homo sapiens	33-38
24377605-5	2013	RESULTS: Genotype frequencies of XRCC1 Arg399Gln observed in controls were 34.2%, 42.5% and 23.3% for GG (Arg/Arg), GA (Arg/Gln), AA( Gln/Gln), respectively, and 28.3%, 66.7% and 5% in cases, with an odds ratio (OR)=5.7 and 95% confidence interval (CI) =2.3-14.1 (p=0.0001).	Arginine	106-109	X-ray repair cross complementing 1	Homo sapiens	33-38
23534753-4	2013	Our findings indicated XRCC1 399Gln/Gln genotype was associated with a significant difference in the median survival time compared with patients carrying Arg/Trp and Arg/Arg genotypes, and individuals with XPD 751 Gln/ Gln genotype had a significantly greater survival time than patients carrying Lys/Lys and Lys/Gln genotypes.	Arginine	154-157	X-ray repair cross complementing 1	Homo sapiens	23-28
23984333-8	2013	The presence of the epitope Bw4 determines a conformational change which leads to a stronger interaction between nonpolymorphic arginine at position 79 of HLA-B and KIR3DL1*001 136-142 loop.	Arginine	128-136	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	Homo sapiens	165-172
23484198-4	2013	Arg-Arg in position 16 in ADRB2 receptors determines the developmental risk of side effects, while Gly-Gly in the same codon determines tolerance to beta2-adrenoceptor agonists and is associated with more severe course of myasthenia and resistance to beta2-adrenoceptor agonists treatment with ADRB2 agonists.	Arginine	0-3	adrenoceptor beta 2	Homo sapiens	26-31
23484198-4	2013	Arg-Arg in position 16 in ADRB2 receptors determines the developmental risk of side effects, while Gly-Gly in the same codon determines tolerance to beta2-adrenoceptor agonists and is associated with more severe course of myasthenia and resistance to beta2-adrenoceptor agonists treatment with ADRB2 agonists.	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	26-31
23451136-3	2013	However, the mechanism by which PRMT5 utilizes MEP50 to discriminate substrates and to specifically methylate target arginines is unclear.	Arginine	117-126	protein arginine methyltransferase 5 L homeolog	Xenopus laevis	32-37
23925152-0	2013	Arginine insertion and loss of N-linked glycosylation site in HIV-1 envelope V3 region confer CXCR4-tropism.	Arginine	0-8	C-X-C motif chemokine receptor 4	Homo sapiens	94-99
23925152-4	2013	The insertion of arginine at position 11 and the loss of the N-linked glycosylation site were indispensable for acquiring pure CXCR4-tropism, which were confirmed by cell-cell fusion assay and phenotype analysis of recombinant HIV-1 variants.	Arginine	17-25	C-X-C motif chemokine receptor 4	Homo sapiens	127-132
23925152-6	2013	The combination of arginine insertion and loss of N-linked glycosylation site usually confers CXCR4-tropism.	Arginine	19-27	C-X-C motif chemokine receptor 4	Homo sapiens	94-99
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Arginine	138-146	solute carrier family 66 member 1	Homo sapiens	27-32
23169667-5	2012	Heterologous expression of PQLC2 at the yeast vacuole rescues the resistance phenotype of an ypq2 mutant to canavanine, a toxic analog of arginine efficiently transported by PQLC2.	Arginine	138-146	solute carrier family 66 member 1	Homo sapiens	174-179
22928666-7	2012	Furthermore, S6K1 overexpression exerts the same effects as Arg-II on endothelial senescence and inflammation responses, which are prevented by silencing Arg-II, demonstrating a role of Arg-II as the mediator of S6K1-induced endothelial aging.	Arginine	154-157	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	13-17
22928666-7	2012	Furthermore, S6K1 overexpression exerts the same effects as Arg-II on endothelial senescence and inflammation responses, which are prevented by silencing Arg-II, demonstrating a role of Arg-II as the mediator of S6K1-induced endothelial aging.	Arginine	154-157	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	13-17
22928666-8	2012	Interestingly, mice that are deficient in Arg-II gene (Arg-II(-/-) ) are not only protected from age-associated increase in Arg-II, VCAM1/ICAM1, aging markers, and eNOS-uncoupling in the aortas but also reveal a decrease in S6K1 activity.	Arginine	42-45	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	224-228
22928666-9	2012	Similarly, silencing Arg-II in senescent cells decreases S6K1 activity, demonstrating that Arg-II also stimulates S6K1 in aging.	Arginine	21-24	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	57-61
22928666-9	2012	Similarly, silencing Arg-II in senescent cells decreases S6K1 activity, demonstrating that Arg-II also stimulates S6K1 in aging.	Arginine	91-94	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	114-118
23100514-8	2012	Loss of Abl and Arg expression or treatment with Abl inhibitors reduced Syk phosphorylation in response to FcgammaR ligation.	Arginine	16-19	spleen tyrosine kinase	Mus musculus	72-75
23136435-4	2012	Using molecular dynamic simulations of membrane-embedded SybII, we show that Trp residues of the JMD influence the electrostatic surface potential by controlling the position of neighboring lysine and arginine residues at the membrane-water interface.	Arginine	201-209	vesicle-associated membrane protein 2	Mus musculus	57-62
22872859-4	2012	5FMC is a nuclear complex that can only be recruited by Chtop when the latter is arginine-methylated by Prmt1.	Arginine	81-89	protein arginine methyltransferase 1	Homo sapiens	104-109
22997150-1	2012	Protein arginine methylation is a PTM catalyzed by an evolutionarily conserved family of enzymes called protein arginine methyltransferases (PRMTs), with PRMT1 being the most conserved member of this enzyme family.	Arginine	8-16	protein arginine methyltransferase 1	Homo sapiens	154-159
23077255-4	2012	Furthermore, the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3, and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1.	Arginine	112-120	spindlin 1	Homo sapiens	221-230
22995619-5	2012	Among analogs with substitutions of arginine at position 53, N(omega)(-)methylarginine analog 8 showed 3-fold more potent agonistic activity compared with metastin(45-54).	Arginine	36-44	KiSS-1 metastasis suppressor	Homo sapiens	155-163
22705350-6	2012	Lysine to arginine mutations within repeats 5-7 identified K394 as the major Rad6B ubiquitination site in vitro and in vivo, and confirmed by Rad6B ubiquitination of a beta-catenin peptide encompassing K394.	Arginine	10-18	ubiquitin conjugating enzyme E2 B	Homo sapiens	77-82
22698803-0	2012	Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice.	Arginine	57-67	thrombopoietin	Mus musculus	15-29
22698803-4	2012	Serum TPO was assayed in necrotizing pancreatitis induced by L-arginine in mice.	Arginine	61-71	thrombopoietin	Mus musculus	6-9
22698803-13	2012	In conclusion, serum TPO is up-regulated in the necrotizing pancreatitis induced by L-arginine in mice and may be a risk factor for the pancreatic acinar necrosis in AP.	Arginine	84-94	thrombopoietin	Mus musculus	21-24
22767504-7	2012	Moreover, a peptide pADPr blot assay of G3BP revealed that pADPr binds to the glycine-arginine-rich domain of G3BP.	Arginine	86-94	G3BP stress granule assembly factor 1	Homo sapiens	40-44
22767504-7	2012	Moreover, a peptide pADPr blot assay of G3BP revealed that pADPr binds to the glycine-arginine-rich domain of G3BP.	Arginine	86-94	G3BP stress granule assembly factor 1	Homo sapiens	110-114
22796489-1	2012	Agmatine (l-amino-4-guanidino-butane), a metabolite of L-arginine through the action of arginine decarboxylase, is a novel neurotransmitter.	Arginine	55-65	antizyme inhibitor 2	Rattus norvegicus	88-110
22863532-2	2012	We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of Pax7.	Arginine	135-144	coactivator associated arginine methyltransferase 1	Homo sapiens	45-50
22863532-2	2012	We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of Pax7.	Arginine	135-144	paired box 7	Homo sapiens	56-60
22863532-2	2012	We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of Pax7.	Arginine	135-144	coactivator associated arginine methyltransferase 1	Homo sapiens	96-101
22863532-2	2012	We identified the arginine methyltransferase Carm1 as a Pax7 interacting protein and found that Carm1 specifically methylates multiple arginines in the N terminus of Pax7.	Arginine	135-144	paired box 7	Homo sapiens	166-170
22863532-5	2012	We defined the C-terminal MLL region as a reader domain for the recognition of arginine methylated proteins such as Pax7.	Arginine	79-87	paired box 7	Homo sapiens	116-120
22863532-6	2012	Thus, arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program.	Arginine	6-14	paired box 7	Homo sapiens	30-34
22863532-6	2012	Thus, arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program.	Arginine	6-14	coactivator associated arginine methyltransferase 1	Homo sapiens	38-43
22863532-6	2012	Thus, arginine methylation of Pax7 by Carm1 functions as a molecular switch controlling the epigenetic induction of Myf5 during satellite stem cell asymmetric division and entry into the myogenic program.	Arginine	6-14	myogenic factor 5	Homo sapiens	116-120
22943296-5	2012	Further, the residues Lys 18, Thr 20, Ala 21, Val 22, Phe 46, Glu 48, Lys 50, Lys 58, Thr 75, Gln 77, Arg 97 and Ile 98 form hot point motif, which on interaction enhances BDNF"s function.	Arginine	102-105	brain derived neurotrophic factor	Homo sapiens	172-176
21975054-1	2012	Arginase 1 and arginase 2 catalyze the hydrolysis of arginine to ornithine and urea.	Arginine	53-61	arginase 2	Rattus norvegicus	15-25
21805378-7	2012	The XRCC1 399Arg/Arg genotype carriers had a higher response rate than that of the Gln genotype carriers (OR = 4.81, 95%CI = 1.778-13.013, P = 0.002).	Arginine	13-16	X-ray repair cross complementing 1	Homo sapiens	4-9
22850414-9	2012	After transfection, cell-free media containing Arg-124 TGFBIp led to Abeta aggregation within 12 hours, whereas wild-type and Arg-555 mutant displayed aggregation after 24 hours.	Arginine	47-50	transforming growth factor beta induced	Homo sapiens	55-61
22552935-0	2012	Attenuated glomerular arginine transport prevents hyperfiltration and induces HIF-1alpha in the pregnant uremic rat.	Arginine	22-30	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	78-88
22552935-7	2012	alpha-Tocopherol (PKC inhibitor) significantly increased arginine transport in both pregnant and CRF pregnant rats, effects that were attenuated by ex vivo incubation of glomeruli with PMA (a PKC stimulant).	Arginine	57-65	protein kinase C, alpha	Rattus norvegicus	18-21
22552935-7	2012	alpha-Tocopherol (PKC inhibitor) significantly increased arginine transport in both pregnant and CRF pregnant rats, effects that were attenuated by ex vivo incubation of glomeruli with PMA (a PKC stimulant).	Arginine	57-65	protein kinase C, alpha	Rattus norvegicus	192-195
22552935-9	2012	Inulin and p-aminohippurate clearances failed to augment and renal cortical expression of hypoxia inducible factor-1alpha (HIF-1alpha) significantly increased in CRF pregnant rat, findings that were prevented by arginine.	Arginine	212-220	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	90-121
22552935-9	2012	Inulin and p-aminohippurate clearances failed to augment and renal cortical expression of hypoxia inducible factor-1alpha (HIF-1alpha) significantly increased in CRF pregnant rat, findings that were prevented by arginine.	Arginine	212-220	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	123-133
22552935-10	2012	These studies suggest that in CRF rats, pregnancy induces a profound decrease in glomerular arginine transport, through posttranslational regulation of CAT-1 by PKC-alpha, resulting in attenuated NO generation.	Arginine	92-100	protein kinase C, alpha	Rattus norvegicus	161-170
22696466-5	2012	Further experiments using immunofluorescence and Western blotting showed that the delivered CARM1 protein can effectively methylate the arginine 17 residue of histone H3 in both bone marrow (BM)- and adipose-derived (AD)-hMSCs, thus suggesting that the CARM1 protein delivered by the CPP system is biologically active in hMSCs.	Arginine	136-144	coactivator associated arginine methyltransferase 1	Homo sapiens	92-97
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	214-222	chromosome 20 open reading frame 181	Homo sapiens	83-86
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	214-222	chromosome 20 open reading frame 181	Homo sapiens	180-183
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	227-230	chromosome 20 open reading frame 181	Homo sapiens	83-86
22610100-6	2012	Peptide sequencing studies performed on the cleaved-off products obtained from the tPA treatment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated cleavage occurred at arginine 67 (Arg(67)).	Arginine	227-230	chromosome 20 open reading frame 181	Homo sapiens	180-183
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	93-96	chromosome 20 open reading frame 181	Homo sapiens	17-20
22610100-7	2012	This cleavage is tPA-specific, plasmin-independent, and removes a predicted ~4-kDa fragment (Arg(27)-Arg(67)) from the amino-terminal domain of the NR2B protein.	Arginine	101-104	chromosome 20 open reading frame 181	Homo sapiens	17-20
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	83-86	chromosome 20 open reading frame 181	Homo sapiens	57-60
22610100-9	2012	This analysis revealed that NR2B is a novel substrate of tPA and suggested that an Arg(27)-Arg(67)-truncated NR2B-containing NMDA receptor could be formed.	Arginine	91-94	chromosome 20 open reading frame 181	Homo sapiens	57-60
22822152-4	2012	Loss of laat-1 caused accumulation of lysine and arginine in enlarged, degradation-defective lysosomes.	Arginine	49-57	Lysosomal amino acid transporter 1	Caenorhabditis elegans	8-14
22822152-6	2012	LAAT-1 also maintained availability of cytosolic lysine/arginine during embryogenesis.	Arginine	56-64	Lysosomal amino acid transporter 1	Caenorhabditis elegans	0-6
22810897-2	2012	Here, we uncovered a previously uncharacterized role for the Abl family tyrosine kinases Abl and Arg in the regulation of T cell-dependent inflammatory responses and showed that the Abl family kinases were required for chemokine-induced T cell polarization and migration.	Arginine	97-100	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	61-64
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Arginine	41-49	orthodenticle homeobox 2	Mus musculus	85-89
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Arginine	41-49	orthodenticle homeobox 2	Mus musculus	177-181
21839495-0	2012	Expression of insulin-like growth factor binding protein-4 (IGFBP-4) in acute pancreatitis induced by L-arginine in mice.	Arginine	102-112	insulin-like growth factor binding protein 4	Mus musculus	14-58
21839495-0	2012	Expression of insulin-like growth factor binding protein-4 (IGFBP-4) in acute pancreatitis induced by L-arginine in mice.	Arginine	102-112	insulin-like growth factor binding protein 4	Mus musculus	60-67
21839495-3	2012	The aim of the study was to examine the expression of IGFBP-4 in mice with acute pancreatitis induced by two doses of L-arginine.	Arginine	118-128	insulin-like growth factor binding protein 4	Mus musculus	54-61
21839495-5	2012	Microarray test of pancreatic mRNA showed that IGFBP-4 mRNA increased significantly after L-arginine treatment and the increase was confirmed by real-time RT-PCR.	Arginine	90-100	insulin-like growth factor binding protein 4	Mus musculus	47-54
21839495-8	2012	In the pancreatic tissues of mice with pancreatitis induced by L-arginine, the immunolocalization of IGFBP-4 was detected in both acinar cells and pancreatic islets.	Arginine	63-73	insulin-like growth factor binding protein 4	Mus musculus	101-108
21839495-9	2012	In conclusion, our results suggest that IGFBP-4 may play a potential role in pancreatic injury and regeneration in a murine model of acute pancreatitis induced by L-arginine.	Arginine	163-173	insulin-like growth factor binding protein 4	Mus musculus	40-47
22443861-1	2012	BACKGROUND INFORMATION: The arginine-type soluble N-ethylmaleimide-sensitive factor attachment protein receptor (R-SNARE) ykt6 possesses several atypical properties including selective high expression in neurons, a lipidated C-terminus, localization to punctae that do not correspond with known endomembrane markers, a potent ability to protect the secretory pathway from alpha-synuclein over-expression and specific up-regulation in tumors.	Arginine	28-36	synuclein alpha	Rattus norvegicus	372-387
22425524-5	2012	In addition, mutation analysis of TPR peptide demonstrated that the highly conserved amino acids Lys and Arg were critical to the cytotoxic activity.	Arginine	105-108	translocated promoter region, nuclear basket protein	Homo sapiens	34-37
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Arginine	10-18	sirtuin 1	Homo sapiens	32-37
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Arginine	10-18	lysine acetyltransferase 5	Homo sapiens	67-72
22586264-6	2012	Lysine-to-arginine mutations in SIRT1-targeted lysines on hMOF and TIP60 repress DNA double-strand break repair and inhibit the ability of hMOF/TIP60 to induce apoptosis in response to DNA double-strand break.	Arginine	10-18	lysine acetyltransferase 5	Homo sapiens	144-149
22546681-1	2012	Arginine-grafted bio-reducible poly(disulfide amine) (ABP) was incorporated into the poly(amido amine) (PAMAM) dendrimer, creating a high molecular weight bio-reducible polymer, PAM-ABP, to overcome the limitations of the low molecular weight ABP.	Arginine	0-8	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	104-107
22535957-5	2012	The Na(+)/K(+) ATPase-dependent surface expression of PLM could be facilitated by either a phosphorylation-mimicking mutation at Thr-69 or a truncation of three terminal arginine residues.	Arginine	170-178	ATPase Na+/K+ transporting subunit beta 1 L homeolog	Xenopus laevis	4-21
22535957-5	2012	The Na(+)/K(+) ATPase-dependent surface expression of PLM could be facilitated by either a phosphorylation-mimicking mutation at Thr-69 or a truncation of three terminal arginine residues.	Arginine	170-178	FXYD domain containing ion transport regulator 1 L homeolog	Xenopus laevis	54-57
22481018-6	2012	A single CGT (Arg) to CAT (His) mutation at codon 119 that is shared by the human and great ape clade greatly reduces this stability and could cause the loss of uricase activity.	Arginine	14-17	urate oxidase (pseudogene)	Homo sapiens	161-168
22300440-6	2012	Also, CYP19A1 arginine allele in homozygosity or heterozygosity (TC/CC) was associated with a significant increased risk for breast cancer when associated to GSTM1 null genotype (OR=6.158; 95% CI=2.676-14.171; p&lt;0.001) and GSTT1 null genotype (OR=4.870; 95% CI=2.216-10.700; p&lt;0.001).	Arginine	14-22	glutathione S-transferase theta 1	Homo sapiens	226-231
22302399-8	2012	It was found that combination of the Arg/Gln or Gln/Gln genotypes of XRCC1 Arg399Gln polymorphism with the two possible genotypes of XPD-Asp312Asn or with the Lys/Gln or Gln/Gln genotypes of XPD Lys751Gln was significantly associated with the development of ESRD.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	69-74
22467876-8	2012	Molecular dynamics simulations and (31)P NMR spectroscopy indicate that phosphorylated serines participate in intramolecular interactions with and sequester arginine residues required for EB1 binding.	Arginine	157-165	microtubule associated protein RP/EB family member 1	Homo sapiens	188-191
22364218-3	2012	We previously identified a conserved surface-exposed arginine (Arg(30)) in the beta-propeller of Coronin 1B required for F-actin binding in vitro and in vivo.	Arginine	53-61	coronin 1B	Homo sapiens	97-107
22364218-3	2012	We previously identified a conserved surface-exposed arginine (Arg(30)) in the beta-propeller of Coronin 1B required for F-actin binding in vitro and in vivo.	Arginine	63-66	coronin 1B	Homo sapiens	97-107
22357953-0	2012	Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.	Arginine	56-64	LDL receptor related protein 6	Homo sapiens	17-21
22357953-3	2012	We report a novel role for arginine methylation in regulating Wnt3a-stimulated LRP6 phosphorylation.	Arginine	27-35	LDL receptor related protein 6	Homo sapiens	79-83
22357953-6	2012	Arginine methylation of G3BP2 appears to be a Wnt3a-sensitive "switch" regulating LRP6 phosphorylation and canonical Wnt-beta-catenin signaling.	Arginine	0-8	LDL receptor related protein 6	Homo sapiens	82-86
22411993-1	2012	Factor (F)VIII can be activated to FVIIIa by FXa following cleavages at Arg(372), Arg(740), and Arg(1689).	Arginine	72-75	coagulation factor X	Homo sapiens	45-48
22411993-1	2012	Factor (F)VIII can be activated to FVIIIa by FXa following cleavages at Arg(372), Arg(740), and Arg(1689).	Arginine	82-85	coagulation factor X	Homo sapiens	45-48
22411993-1	2012	Factor (F)VIII can be activated to FVIIIa by FXa following cleavages at Arg(372), Arg(740), and Arg(1689).	Arginine	82-85	coagulation factor X	Homo sapiens	45-48
22411993-2	2012	FXa also cleaves FVIII/FVIIIa at Arg(336) and Arg(562) resulting in inactivation of the cofactor.	Arginine	33-36	coagulation factor X	Homo sapiens	0-3
22411993-2	2012	FXa also cleaves FVIII/FVIIIa at Arg(336) and Arg(562) resulting in inactivation of the cofactor.	Arginine	46-49	coagulation factor X	Homo sapiens	0-3
22411993-5	2012	Replacing P4-P3" residues flanking Arg(336) with those from Arg(372) or Arg(740) resulted in ~4-6-fold increases in rates of FXa-catalyzed inactivation of FVIIIa, which paralleled the rates of proteolysis at Arg(336).	Arginine	35-38	coagulation factor X	Homo sapiens	125-128
22411993-5	2012	Replacing P4-P3" residues flanking Arg(336) with those from Arg(372) or Arg(740) resulted in ~4-6-fold increases in rates of FXa-catalyzed inactivation of FVIIIa, which paralleled the rates of proteolysis at Arg(336).	Arginine	60-63	coagulation factor X	Homo sapiens	125-128
22411993-5	2012	Replacing P4-P3" residues flanking Arg(336) with those from Arg(372) or Arg(740) resulted in ~4-6-fold increases in rates of FXa-catalyzed inactivation of FVIIIa, which paralleled the rates of proteolysis at Arg(336).	Arginine	60-63	coagulation factor X	Homo sapiens	125-128
22411993-5	2012	Replacing P4-P3" residues flanking Arg(336) with those from Arg(372) or Arg(740) resulted in ~4-6-fold increases in rates of FXa-catalyzed inactivation of FVIIIa, which paralleled the rates of proteolysis at Arg(336).	Arginine	60-63	coagulation factor X	Homo sapiens	125-128
22411993-8	2012	The capacity for FXa to activate FVIII variants where cleavage at Arg(336) was accelerated due to flanking sequence replacement showed marked reductions in peak activity, whereas reducing the cleavage rate at this site enhanced peak activity.	Arginine	66-69	coagulation factor X	Homo sapiens	17-20
22541557-1	2012	Argininosuccinate lyase (ASL) is required for the synthesis and channeling of L-arginine to nitric oxide synthase (NOS) for nitric oxide (NO) production.	Arginine	78-88	argininosuccinate lyase	Mus musculus	0-23
22541557-1	2012	Argininosuccinate lyase (ASL) is required for the synthesis and channeling of L-arginine to nitric oxide synthase (NOS) for nitric oxide (NO) production.	Arginine	78-88	argininosuccinate lyase	Mus musculus	25-28
22286370-5	2012	Glucose- and arginine-stimulated insulin secretion, insulin sensitivity and glucose effectiveness were measured in vivo before and during treatment (days 10-14), and beta-cell mass was measured at the end of treatment.	Arginine	13-21	LOC105613195	Ovis aries	33-40
22391343-3	2012	The mutation (CAT  CGT), which has occurred at codon 151, at nucleotide position 524, implies an amino acidic change from Histidine to Arginine.	Arginine	135-143	UDP glycosyltransferase 8	Homo sapiens	19-22
22334670-9	2012	We found that this amino acid (Arg) is conserved in the AtMYC1 homologs GL3/EGL3 and that it is essential for their interaction with MYB proteins and for their proper functions.	Arginine	31-34	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	72-75
22334670-9	2012	We found that this amino acid (Arg) is conserved in the AtMYC1 homologs GL3/EGL3 and that it is essential for their interaction with MYB proteins and for their proper functions.	Arginine	31-34	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	76-80
21892207-5	2012	Using siRNA and pharmacological approaches, we show that c-Abl/Arg activation is functionally relevant because it is requiredfor melanoma cell proliferation, survival and invasion.	Arginine	63-66	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	57-62
21892207-8	2012	Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis in a mouse model.	Arginine	28-31	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	158-163
21892207-8	2012	Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis in a mouse model.	Arginine	28-31	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	158-163
21892207-8	2012	Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis in a mouse model.	Arginine	164-167	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	18-23
21892207-8	2012	Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis in a mouse model.	Arginine	164-167	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	158-163
21892207-8	2012	Most importantly, c-Abl and Arg not only promote in vitro processes important for melanoma progression, but also promote metastasis in vivo, as inhibition of c-Abl/Arg kinase activity with the c-Abl/Arg inhibitor, nilotinib, dramatically inhibits metastasis in a mouse model.	Arginine	164-167	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	158-163
22327218-4	2012	We show here that E2F-1 is directly methylated by PRMT5 (protein arginine methyltransferase 5), and that arginine methylation is responsible for regulating its biochemical and functional properties, which impacts on E2F-1-dependent growth control.	Arginine	65-73	protein arginine methyltransferase 5 L homeolog	Xenopus laevis	50-55
21848502-5	2012	Results showed that 50 mug/mL of NAC, SDC, GSH, CS, Arg, Azone, SPC, SNP, and 10 mug/mL of SNP had a significant enhancing effect on promoting the transport of insulin across the TR146 cell model.	Arginine	52-55	X-linked Kx blood group	Homo sapiens	33-36
22431096-4	2012	The cross-referencing of these mutations in candidate genes for muscular dystrophy showed a homozygote mutation c.G674A in exon 4 of LMNA causing a protein change R225Q in an arginine conserved from human to Xenopus tropicalis and in lamin B1.	Arginine	175-183	lamin B1	Xenopus tropicalis	234-242
22457888-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	integrin subunit alpha V	Homo sapiens	12-32
22457888-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	vitronectin	Homo sapiens	81-92
22457890-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	integrin subunit alpha V	Homo sapiens	12-32
22457890-4	2004	Because the integrin alphavbeta3 binds with extracellular matrix proteins (e.g., vitronectin, fibronectin) through the exposed Arg-Gly-Asp tripeptide sequence, RGD-containing peptides have been intensively studied in the past decade as a vector for imaging alphavbeta3 expression (3, 4).	Arginine	127-130	vitronectin	Homo sapiens	81-92
22241471-0	2012	Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming omega-NG-monomethylated arginine residues.	Arginine	14-22	protein arginine methyltransferase 7	Homo sapiens	44-49
22241471-1	2012	Full-length human protein arginine methyltransferase 7 (PRMT7) expressed as a fusion protein in Escherichia coli was initially found to generate only omega-N(G)-monomethylated arginine residues in small peptides, suggesting that it is a type III enzyme.	Arginine	26-34	protein arginine methyltransferase 7	Homo sapiens	56-61
22241471-2	2012	A later study, however, characterized fusion proteins of PRMT7 expressed in bacterial and mammalian cells as a type II/type I enzyme, capable of producing symmetrically dimethylated arginine (type II activity) as well as small amounts of asymmetric dimethylarginine (type I activity).	Arginine	182-190	protein arginine methyltransferase 7	Homo sapiens	57-62
22241471-4	2012	We analyzed the in vitro methylation products of a glutathione S-transferase (GST)-PRMT7 fusion protein with robust activity using a variety of arginine-containing synthetic peptides and protein substrates, including a GST fusion with the N-terminal domain of fibrillarin (GST-GAR), myelin basic protein, and recombinant human histones H2A, H2B, H3, and H4.	Arginine	144-152	protein arginine methyltransferase 7	Homo sapiens	83-88
22234469-6	2012	Gly(391) forms part of the type I receptor binding site on hGDF9, and this residue is present in all species except mouse, rat, hamster, galago, and possum, in which it is substituted with an arginine.	Arginine	192-200	growth differentiation factor 9	Homo sapiens	59-64
22234469-9	2012	An arginine at position 391 increases the affinity of GDF9 for its signaling receptors, enabling it to be secreted in an active form.	Arginine	3-11	growth differentiation factor 9	Homo sapiens	54-58
22173094-3	2012	A conserved Arg residue (Arg375 in iNOS) forms hydrogen bonds with the H(4)B ring.	Arginine	12-15	H4 clustered histone 4	Homo sapiens	71-76
21878453-2	2012	Through its enzymatic activity PAD2 converts myelin basic protein (MBP) arginines into citrullines - an event that may favour autoimmunity - while peptidylarginine deiminase 4 (PAD4) is involved in chromatin remodelling.	Arginine	72-81	peptidyl arginine deiminase 2	Homo sapiens	31-35
22239978-12	2012	CONCLUSION: Ginsenoside Rb1 and Rg1 increased endothelial-dependent vessel dilatation through the activation of NO by modulating the PI3K/Akt/eNOS pathway and l-arginine transport in endothelial cells.	Arginine	159-169	RB transcriptional corepressor 1	Mus musculus	24-27
22359779-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
22359781-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
22319801-15	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	136-147
21963434-1	2012	Argininosuccinate lyase (ASL) catalyzes the conversion of argininosuccinate into arginine and fumarate, a key step in the biosynthesis of urea and arginine.	Arginine	81-89	argininosuccinate lyase	Homo sapiens	0-23
21963434-1	2012	Argininosuccinate lyase (ASL) catalyzes the conversion of argininosuccinate into arginine and fumarate, a key step in the biosynthesis of urea and arginine.	Arginine	147-155	argininosuccinate lyase	Homo sapiens	0-23
22231402-2	2012	We report the crystal structure of the chloroplast signal recognition particle (cpSRP) core from Arabidopsis thaliana, with the cpSRP54 tail comprising an arginine-rich motif bound to the second chromodomain of cpSRP43.	Arginine	155-163	chloroplast signal recognition particle 54 kDa subunit	Arabidopsis thaliana	128-135
22938418-6	2012	Our study showed a lower survival rate in XRCC1 399 Arg/Arg genotype than Gln/ Gln, with a significant increased risk of death (HR=1.69, 95%CI=1.07-2.78).	Arginine	52-55	X-ray repair cross complementing 1	Homo sapiens	42-47
22938418-6	2012	Our study showed a lower survival rate in XRCC1 399 Arg/Arg genotype than Gln/ Gln, with a significant increased risk of death (HR=1.69, 95%CI=1.07-2.78).	Arginine	56-59	X-ray repair cross complementing 1	Homo sapiens	42-47
23167335-10	2012	Although the MDM2 309G allele was itself without affect, it showed a synergistic effect with P21 ser/arg polymorphism (P value=0.003, OR= 6.807, 95% CI= 1.909-24.629).	Arginine	101-104	MDM2 proto-oncogene	Homo sapiens	13-17
23167352-6	2012	For XRCC1 Arg194Trp, the variant genotype Trp/Trp was significantly associated with a decreased risk of death from NSCLC when compared with the Arg/Arg.	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	4-9
23464469-6	2012	As for response to platinum- based chemotherapy, the variant XRCC1 399Gln allele (Gln vs. Arg, OR=0.345, 95% CI: 0.163, 0.729) was linked with a poor response; however, the Arg194Trp polymorphism (TrpArg vs. ArgArg, OR=6.421, 95% CI: 1.573, 26.205) predicted a good response.	Arginine	90-93	X-ray repair cross complementing 1	Homo sapiens	61-66
22272823-3	2012	Peptide RGD sequence Arg-Gly-Asp targeted and combined to integrin alphavbeta3 which has been overexpressed on tumor endothelial cells and many different tumor cellsis a robust site for tumor angiogenesis molecular imaging and targeted therapy.	Arginine	21-24	integrin subunit alpha V	Homo sapiens	58-78
21965298-0	2012	Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	24-29
22904671-6	2012	Each monomer of the Aqy1 tetramers forms a channel whose walls consist mostly of hydrophilic residues, transporting through the selectivity filter containing Arg-227, His-212, Phe-92, and Ala-221, and the two conserved Asn-Pro-Ala (NPA) motifs containing asparagines 224 and 112.	Arginine	158-161	Aqy1p	Saccharomyces cerevisiae S288C	20-24
22811266-7	2012	Furthermore, the ecmA CA-rich elements show sequence similarity to the core consensus Ndt80 binding site (the MSE) and point mutation of highly conserved arginine residues in MrfA, that in Ndt80 make critical contacts with the MSE, ablate binding of MrfA to its sites within the ecmA promoter.	Arginine	154-162	transcription factor NDT80	Saccharomyces cerevisiae S288C	189-194
22675626-2	2012	Abl and its paralog, Arg, are unique among the tyrosine kinase family in that they contain an unusual extended C-terminal half consisting of multiple functional domains.	Arginine	21-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-3
22686320-5	2012	In the whole study group (n=301) there was a trend for increasing adduct values for XRCC1 Arg(GG)399Gln(AA) during a shift, especially in nonsmokers (n=108.	Arginine	90-93	X-ray repair cross complementing 1	Homo sapiens	84-89
22686320-7	2012	In contrast, XRCC1 Arg(GG)280His(AA) showed a decrease of median Delta8-oxodGuo/10(6) dGuo values in workers with exposure to vapors and aerosols of bitumen (n=214), especially in smokers (n=145).	Arginine	19-22	X-ray repair cross complementing 1	Homo sapiens	13-18
23152885-0	2012	The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	14-19
23152885-4	2012	The modulation of arginine methylation levels by a general methyltransferase inhibitor or conditional over-expression of PRMT1 altered slightly the nucleus-cytoplasmic ratio of FUS/TLS in cell fractionation assays.	Arginine	18-26	protein arginine methyltransferase 1	Homo sapiens	121-126
23152885-8	2012	These findings indicate that PRMT1-mediated arginine methylation could be implicated in the nucleus-cytoplasmic shuttling of FUS/TLS and in the SGs formation and the detergent-insoluble inclusions of ALS-linked FUS/TLS mutants.	Arginine	44-52	protein arginine methyltransferase 1	Homo sapiens	29-34
22427951-2	2012	A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of rheumatoid arthritis among non-HLA genetic variations that are known to be associated with this disease.	Arginine	110-118	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	80-86
22253860-7	2012	The overall best model by MDR was tobacco habit/p53(Arg/Arg)/XRCC1(Arg399His)/mEH(Tyr113His) that had highest Cross Validation Consistency (8.3) and test accuracy (0.69).	Arginine	52-55	X-ray repair cross complementing 1	Homo sapiens	61-66
22253860-7	2012	The overall best model by MDR was tobacco habit/p53(Arg/Arg)/XRCC1(Arg399His)/mEH(Tyr113His) that had highest Cross Validation Consistency (8.3) and test accuracy (0.69).	Arginine	56-59	X-ray repair cross complementing 1	Homo sapiens	61-66
22623885-4	2012	Dietary L-arginine intake directed adenine nucleotide metabolism in liver, kidney, and testis tissue toward the activation of adenosine production, by increased 5"-NU activity and decreased ADA activity.	Arginine	8-18	adenosine deaminase	Rattus norvegicus	190-193
22013065-5	2011	HopU1 ADP-ribosylates the conserved arginine 49 of GRP7, and this reduces the ability of GRP7 to bind RNA in vitro.	Arginine	36-44	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	51-55
22013065-5	2011	HopU1 ADP-ribosylates the conserved arginine 49 of GRP7, and this reduces the ability of GRP7 to bind RNA in vitro.	Arginine	36-44	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	89-93
22009756-7	2011	We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally deposited protein, is a potent substrate for Prmt5-Mep50 and is monomethylated and symmetrically dimethylated at Arg-187.	Arginine	189-192	nucleophosmin (nucleolar phosphoprotein B23, numatrin) S homeolog	Xenopus laevis	20-33
22009756-7	2011	We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally deposited protein, is a potent substrate for Prmt5-Mep50 and is monomethylated and symmetrically dimethylated at Arg-187.	Arginine	189-192	nucleophosmin (nucleolar phosphoprotein B23, numatrin) S homeolog	Xenopus laevis	35-38
21923750-4	2011	L-arg is transported into cells via the cationic amino acid transporters (CAT), of which there are two isoforms in endothelial cells, CAT-1 and CAT-2.	Arginine	0-5	solute carrier family 7 member 1	Homo sapiens	134-139
21923750-10	2011	In hypoxic cells, overexpression of CAT-1 resulted in significantly greater L-arg transport and NO production (P &lt; 0.05).	Arginine	76-81	solute carrier family 7 member 1	Homo sapiens	36-41
22095898-2	2011	METHODS: We constructed a surface-modified adenoviral vector with RGD (Arg-Gly-Asp) sequences encoding human X-linked inhibitor of apoptosis and hepatocyte growth factor (RGD-Adv-hHGF-hXIAP).	Arginine	71-74	X-linked inhibitor of apoptosis	Homo sapiens	109-140
21962305-2	2011	It has been reported that arginase-2 expression, an alternative pathway for l-arginine metabolism, is increased in adult endothelial cells exposed to hypoxia as well as in pre-eclamptic placentae.	Arginine	76-86	arginase 2	Homo sapiens	26-36
22037576-2	2011	Recently we have demonstrated that a local force applied via Arg-Gly-Asp (RGD) peptides coated magnetic beads to mouse embryonic stem (ES) cells increases cell spreading and cell stiffness and decreases Oct3/4 (Pou5f1) gene expression.	Arginine	61-64	POU domain, class 5, transcription factor 1	Mus musculus	203-209
22037576-2	2011	Recently we have demonstrated that a local force applied via Arg-Gly-Asp (RGD) peptides coated magnetic beads to mouse embryonic stem (ES) cells increases cell spreading and cell stiffness and decreases Oct3/4 (Pou5f1) gene expression.	Arginine	61-64	POU domain, class 5, transcription factor 1	Mus musculus	211-217
21602891-5	2011	Using streptavidin-biotin pull downs and unbiased high-throughput Src Homology 2 (SH2) profiling approaches, we found that a pY251 phosphopeptide binds specifically to a subset of SH2 domains, including Abl and Arg SH2, and that binding of pY251 to Abl SH2 induces transactivation of Abl 1b.	Arginine	211-214	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	203-206
21602891-5	2011	Using streptavidin-biotin pull downs and unbiased high-throughput Src Homology 2 (SH2) profiling approaches, we found that a pY251 phosphopeptide binds specifically to a subset of SH2 domains, including Abl and Arg SH2, and that binding of pY251 to Abl SH2 induces transactivation of Abl 1b.	Arginine	211-214	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	249-252
21602891-5	2011	Using streptavidin-biotin pull downs and unbiased high-throughput Src Homology 2 (SH2) profiling approaches, we found that a pY251 phosphopeptide binds specifically to a subset of SH2 domains, including Abl and Arg SH2, and that binding of pY251 to Abl SH2 induces transactivation of Abl 1b.	Arginine	211-214	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	249-252
22081021-3	2011	Loss of Asl in both humans and mice leads to reduced NO synthesis, owing to both decreased endogenous arginine synthesis and an impaired ability to use extracellular arginine for NO production.	Arginine	102-110	argininosuccinate lyase	Homo sapiens	8-11
22081021-3	2011	Loss of Asl in both humans and mice leads to reduced NO synthesis, owing to both decreased endogenous arginine synthesis and an impaired ability to use extracellular arginine for NO production.	Arginine	166-174	argininosuccinate lyase	Homo sapiens	8-11
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	0-3	adrenoceptor beta 2	Homo sapiens	57-77
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	0-3	adrenoceptor beta 2	Homo sapiens	84-89
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	57-77
21436355-1	2011	Arg/Arg homozygotes for the Gly16Arg polymorphism in the beta2-adrenoreceptor gene (ADRB2) have a reduced response to short-acting beta2-agonists but no effect has been associated with long-acting beta2-agonists (LABAs).	Arginine	4-7	adrenoceptor beta 2	Homo sapiens	84-89
21302286-0	2011	Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation.	Arginine	19-29	solute carrier family 7 member 1	Homo sapiens	49-55
21838253-2	2011	PRMT1 is the founding member of the PRMT family, and this isozyme is responsible for methylating ~85% of the arginine residues in mammalian cells.	Arginine	109-117	protein arginine methyltransferase 1	Homo sapiens	0-5
21880731-6	2011	The binding specificity was determined primarily through the recognition of arginine 2 and lysine 4 of the unH3 by conserved aspartic acids of PHD1 and of threonine 6 of the unH3 by a conserved asparagine.	Arginine	76-84	Phd1p	Saccharomyces cerevisiae S288C	143-147
21807072-0	2011	Pre-aggregated Abeta(25-35) alters arginine metabolism in the rat hippocampus and prefrontal cortex.	Arginine	35-43	amyloid beta precursor protein	Rattus norvegicus	15-20
21807072-10	2011	These results demonstrate that Abeta(25-35) alters arginine metabolism, which further supports the prominent role of arginine and its metabolites in Alzheimer"s disease (AD) pathogenesis.	Arginine	51-59	amyloid beta precursor protein	Rattus norvegicus	31-36
21807072-10	2011	These results demonstrate that Abeta(25-35) alters arginine metabolism, which further supports the prominent role of arginine and its metabolites in Alzheimer"s disease (AD) pathogenesis.	Arginine	117-125	amyloid beta precursor protein	Rattus norvegicus	31-36
21987678-8	2011	Subsequently, we investigated our entire cohort of families with autosomal recessive retinitis pigmentosa and identified 4 additional families with linkage to chromosome 6p, all of them harboring a single base pair substitution in TULP1 that results in lysine to arginine substitution (p.K489R).	Arginine	263-271	TUB like protein 1	Homo sapiens	231-236
21653890-12	2011	In addition, several elements implicated in the control of Ddx4 expression in the mouse, including RGG (arginine-glycine-glycine) and dimethylation of arginine motifs and CpG islands within the Ddx4 promoter, are also highly conserved.	Arginine	104-112	DEAD box helicase 4	Mus musculus	59-63
21653890-12	2011	In addition, several elements implicated in the control of Ddx4 expression in the mouse, including RGG (arginine-glycine-glycine) and dimethylation of arginine motifs and CpG islands within the Ddx4 promoter, are also highly conserved.	Arginine	104-112	DEAD box helicase 4	Mus musculus	194-198
21855157-6	2011	Collectively, DDAH and ADMA are closely associated with the development of obesity and diabetes, and the arginine methylation levels of certain proteins were changed during diabetes development.	Arginine	105-113	dimethylarginine dimethylaminohydrolase 2	Mus musculus	14-18
21784147-7	2011	Therefore, in addition to modulating ( )NO bioavailability by stimulating O(2)( -) production in the endothelium, SAA modulated vascular l-Arg bioavailability.	Arginine	137-142	serum amyloid A1 cluster	Homo sapiens	114-117
21784147-10	2011	Thus, SAA may promote endothelial dysfunction by modulating ( )NO and l-Arg bioavailability, and HDL pretreatment may be protective.	Arginine	70-75	serum amyloid A1 cluster	Homo sapiens	6-9
21851090-2	2011	PRMT1 is responsible for most cellular arginine methylation activity and can work independently or in collaboration with other PRMTs.	Arginine	39-47	protein arginine methyltransferase 1	Homo sapiens	0-5
21808068-7	2011	Catalysis required Arg-803 of RUTBC1, and RUTBC1 could activate a catalytically inhibited Rab33B mutant (Q92A), in support of a dual finger mechanism for RUTBC1 action.	Arginine	19-22	RAB33B, member RAS oncogene family	Homo sapiens	90-96
21497796-2	2011	A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence.	Arginine	42-45	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	17-22
21749319-3	2011	We analysed the phosphorylation consensus motif of PKNs using a peptide library approach and demonstrate that both PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3.	Arginine	193-201	protein kinase N1	Homo sapiens	115-119
21771784-6	2011	The transport features of SLC6A14 include concentrative transport of leucine (an activator of mTOR), glutamine (an essential amino acid for nucleotide biosynthesis and substrate for glutaminolysis), and arginine (an essential amino acid for tumor cells), suggesting that ER-positive breast cancer cells up-regulate SLC6A14 to meet their increased demand for these amino acids.	Arginine	203-211	solute carrier family 6 member 14	Homo sapiens	26-33
21917546-3	2011	Stable isotope labeling experiments show that, after MeJA elicitation, Arg, Pro, and Glu are converted to Orn, which is acetylated by NATA1 to produce N(delta)-acetylornithine.	Arginine	71-74	Acyl-CoA N-acyltransferases (NAT) superfamily protein	Arabidopsis thaliana	134-139
21543238-1	2011	PURPOSE: The purpose of the study was to determine the frequency of occurrence of polymorphisms of genes MTHFR (C677T), MTR (A2756G), and MTHFD1 (G1958A), as well as to analyze the concentration of homocysteine (Hcy), methionine (Met), asymmetric dimethylarginine (ADMA), and arginine (Arg) in epileptics treatment with antiepileptic drugs (AEDs), and controls.	Arginine	255-263	methylenetetrahydrofolate reductase	Homo sapiens	105-110
21543238-1	2011	PURPOSE: The purpose of the study was to determine the frequency of occurrence of polymorphisms of genes MTHFR (C677T), MTR (A2756G), and MTHFD1 (G1958A), as well as to analyze the concentration of homocysteine (Hcy), methionine (Met), asymmetric dimethylarginine (ADMA), and arginine (Arg) in epileptics treatment with antiepileptic drugs (AEDs), and controls.	Arginine	286-289	methylenetetrahydrofolate reductase	Homo sapiens	105-110
21728354-2	2011	The protein kinase SRPK1 phosphorylates ~10 serines in the arginine--serine-rich domain (RS domain) of the SR protein SRSF1 in a C- to N-terminal direction, a modification that directs this essential splicing factor from the cytoplasm to the nucleus.	Arginine	59-67	serine and arginine rich splicing factor 1	Homo sapiens	118-123
21812966-4	2011	HB-19 and related multivalent Nucant pseudopeptides, that present pentavalently or hexavalently the tripeptide Lyspsi(CH2N)-Pro-Arg, were then used to show that targeting surface nucleolin results in distinct inhibitory mechanisms on breast, prostate, colon carcinoma and leukemia cells.	Arginine	128-131	nucleolin	Mus musculus	179-188
21600547-9	2011	CONCLUSION: Homozygous beta2AR genotype encoding for Arg/Arg16 was associated with slower progress in active labor.	Arginine	53-56	adrenoceptor beta 2	Homo sapiens	23-30
21529934-1	2011	Platelet adhesion to adsorbed plasma proteins, such as fibrinogen (Fg), has been conventionally thought to be mediated by the GPIIb/IIIa receptor binding to Arg-Gly-Asp (RGD)-like motifs in the adsorbed protein.	Arginine	157-160	integrin subunit alpha 2b	Homo sapiens	126-131
21860547-5	2011	The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]).	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	4-9
21860547-5	2011	The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]).	Arginine	20-23	X-ray repair cross complementing 1	Homo sapiens	4-9
21860547-5	2011	The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]).	Arginine	20-23	X-ray repair cross complementing 1	Homo sapiens	4-9
21860547-7	2011	Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.	Arginine	34-37	X-ray repair cross complementing 1	Homo sapiens	28-33
21306750-5	2011	At basal (2.8 mmol/L) and stimulatory (11.1 mmol/L) glucose concentrations, the insulin secretion rates induced by depolarizing agents such as KCl, L-arginine, and tolbutamide were significantly reduced in LDLR(-/-) when compared with control (WT) islets.	Arginine	148-158	low density lipoprotein receptor	Mus musculus	206-210
21909610-5	2011	The mutation was identified as the sixty four base pair in exon 2 of SDHB(c.136C&gt;T), resulting in a change from a arginine to a stop codon (p.Arg90X).	Arginine	117-125	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	69-73
21777816-5	2011	Importantly, we show that UHRF1"s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF1 function.	Arginine	275-283	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	26-31
21777816-5	2011	Importantly, we show that UHRF1"s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF1 function.	Arginine	275-283	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	107-112
21777816-5	2011	Importantly, we show that UHRF1"s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2, thereby demonstrating the functional importance of this recognition event and supporting the potential for crosstalk between histone arginine methylation and UHRF1 function.	Arginine	275-283	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	107-112
21743441-5	2011	Furthermore, we find that Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.	Arginine	194-203	tudor domain containing 1	Danio rerio	26-31
21743441-5	2011	Furthermore, we find that Tdrd1 binds both zebrafish Piwi proteins, Ziwi and Zili, and reveals sequence specificity in the interaction between Tdrd1 tudor domains and symmetrically dimethylated arginines (sDMAs) in Zili.	Arginine	194-203	piwi-like RNA-mediated gene silencing 2	Danio rerio	77-81
21453345-3	2011	LHT1 mutants displayed reduced uptake rates of L-Gln, L-Ala, L-Glu and L-Asp but not of L-Arg or L-Lys, while AAP5 mutants were affected in the uptake of L-Arg and L-Lys only.	Arginine	154-159	amino acid permease 5	Arabidopsis thaliana	110-114
21563828-3	2011	In this study, we demonstrate that purified recombinant human ADAM17 is able to cleave a 20-amino acid peptide mimetic corresponding to the extracellular juxtamembrane region of human ACE2 between Arg(708) and Ser(709).	Arginine	197-200	ADAM metallopeptidase domain 17	Homo sapiens	62-68
21563828-7	2011	In summary, we have demonstrated that ADAM17 is able to cleave ACE2 peptide sequence analogues between Arg(708) and Ser(709).	Arginine	103-106	ADAM metallopeptidase domain 17	Homo sapiens	38-44
21563828-8	2011	These findings also indicate that Arg(708) and Arg(710) play a role in site recognition in the regulation of ACE2 ectodomain shedding mediated by ADAM17.	Arginine	34-37	ADAM metallopeptidase domain 17	Homo sapiens	146-152
21504900-6	2011	Biochemical studies revealed that direct interaction between TRIP8b and the HCN1 CNBD was disrupted by cAMP and that TRIP8b binding to the CNBD required an arginine residue also necessary for cAMP binding.	Arginine	156-164	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	76-80
21504900-6	2011	Biochemical studies revealed that direct interaction between TRIP8b and the HCN1 CNBD was disrupted by cAMP and that TRIP8b binding to the CNBD required an arginine residue also necessary for cAMP binding.	Arginine	156-164	peroxisomal biogenesis factor 5 like	Homo sapiens	117-123
21194352-7	2011	More importantly, enzymatic generation of H(2)S from recombinant cystathionine-gamma-lyase protein also interacted with endogenous NO generated from l-arginine to stimulate heart contraction.	Arginine	149-159	cystathionine gamma-lyase	Homo sapiens	65-90
21410432-1	2011	CARM1 (co-activator-associated arginine methyltransferase 1) is a PRMT (protein arginine N-methyltransferase) family member that catalyses the transfer of methyl groups from SAM (S-adenosylmethionine) to the side chain of specific arginine residues of substrate proteins.	Arginine	31-39	coactivator associated arginine methyltransferase 1	Homo sapiens	0-5
21193457-9	2011	Results Reg4 mRNA and protein were markedly upregulated during arginine-induced pancreatitis.	Arginine	63-71	regenerating islet-derived family, member 4	Mus musculus	8-12
20422421-5	2011	ICAM-1 codon 241 polymorphism analysis was performed by two independent PCR reactions, based on the two set of oligoprimers specific for Arg (AGG) or Gly (GGG) coding sequence, respectively.	Arginine	137-140	intercellular adhesion molecule 1	Homo sapiens	0-6
21446907-3	2011	MMP-9 enzyme recognizes a peptide sequence Lys-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys and cleaves the peptide into two parts.	Arginine	55-58	matrix metallopeptidase 9	Homo sapiens	0-5
21447556-4	2011	Here, we report a novel nuage component, PAPI (Partner of PIWIs), that contains a TUDOR domain and interacts with all three PIWI proteins via symmetrically dimethylated arginine residues in their N-terminal domain.	Arginine	169-177	papi	Drosophila melanogaster	41-45
21447556-4	2011	Here, we report a novel nuage component, PAPI (Partner of PIWIs), that contains a TUDOR domain and interacts with all three PIWI proteins via symmetrically dimethylated arginine residues in their N-terminal domain.	Arginine	169-177	papi	Drosophila melanogaster	47-63
21376061-9	2011	The number of Fos (+) neurons decreased in acute and chronic L-NAME and decreased in acute L-arginine groups.	Arginine	91-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
21376061-10	2011	Following ENSC, Fos (+) neurons did not change in acute L-NAME but decreased in the chronic L-NAME groups, and decreased in both acute and chronic L-arginine groups.	Arginine	147-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-19
21491703-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
21491704-10	2004	A tumor cell targeting peptide, Gly-Ala-Cys-Leu-Arg-Ser-Gly-Arg-Gly-Cys-Gly (TCTP-1), was identified via phage display screening against MMP-9.	Arginine	48-51	matrix metallopeptidase 9	Homo sapiens	137-142
21491704-10	2004	A tumor cell targeting peptide, Gly-Ala-Cys-Leu-Arg-Ser-Gly-Arg-Gly-Cys-Gly (TCTP-1), was identified via phage display screening against MMP-9.	Arginine	60-63	matrix metallopeptidase 9	Homo sapiens	137-142
21308737-0	2011	CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines.	Arginine	15-23	solute carrier family 7 member 1	Homo sapiens	0-5
21159828-4	2011	CONCLUSION: The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.	Arginine	70-78	collagen type IX alpha 2 chain	Homo sapiens	40-46
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Arginine	166-174	ORAI calcium release-activated calcium modulator 1	Homo sapiens	108-113
21220423-4	2011	Employing a chimeric approach by sequential swapping of respective intra- and extracellular regions between Orai1 and Orai3, we show here that Orai1 specific proline/arginine-rich domains in the N terminus mediate reactivation, whereas the second, intracellular loop modulates fast and slow gating processes.	Arginine	166-174	ORAI calcium release-activated calcium modulator 1	Homo sapiens	143-148
21318388-11	2011	The data indicate that the enzyme with arginine at the position corresponding to 163 (hTS) evolved after the divergence of prosimians and simians and that substitution of lysine by arginine confers unique structural and functional properties to the enzyme expressed in simian primates.	Arginine	181-189	APC down-regulated 1	Homo sapiens	86-89
21312326-3	2011	Argininosuccinate lyase (ASL) is a cytosolic enzyme which catalyzes the fourth reaction in the cycle and the first degradative step, that is, the breakdown of argininosuccinic acid to arginine and fumarate.	Arginine	184-192	argininosuccinate lyase	Homo sapiens	0-23
21312326-3	2011	Argininosuccinate lyase (ASL) is a cytosolic enzyme which catalyzes the fourth reaction in the cycle and the first degradative step, that is, the breakdown of argininosuccinic acid to arginine and fumarate.	Arginine	184-192	argininosuccinate lyase	Homo sapiens	25-28
21312326-8	2011	Hence, while ASL is the only enzyme in the body able to generate arginine, at least four enzymes use arginine as substrate: arginine decarboxylase, arginase, nitric oxide synthetase (NOS) and arginine/glycine aminotransferase.	Arginine	65-73	argininosuccinate lyase	Homo sapiens	13-16
21282473-4	2011	Although these changes typically have negative effects on protein function, recent studies suggested that isoAsp formation at certain Asn-Gly-Arg (NGR) sites in ECM proteins have a gain-of-function effect, because the resulting isoAsp-Gly-Arg (isoDGR) sequence can mimic Arg-Gly-Asp (RGD), a well-known integrin-binding motif.	Arginine	142-145	reticulon 4 receptor	Homo sapiens	147-150
20567862-7	2011	The kinetic properties of these variants indicated that the Arg-216 residue is important for the catalytic activity and substrate specificity of mouse DDO.	Arginine	60-63	D-aspartate oxidase	Mus musculus	151-154
20567862-10	2011	Additional experiments using several DDO and DAO inhibitors also suggested the involvement of Arg-216 in the substrate specificity and catalytic activity of mouse DDO and that Arg-237 is possibly involved in substrate recognition by this enzyme.	Arginine	94-97	D-amino acid oxidase	Mus musculus	45-48
20567862-10	2011	Additional experiments using several DDO and DAO inhibitors also suggested the involvement of Arg-216 in the substrate specificity and catalytic activity of mouse DDO and that Arg-237 is possibly involved in substrate recognition by this enzyme.	Arginine	94-97	D-aspartate oxidase	Mus musculus	163-166
20567862-10	2011	Additional experiments using several DDO and DAO inhibitors also suggested the involvement of Arg-216 in the substrate specificity and catalytic activity of mouse DDO and that Arg-237 is possibly involved in substrate recognition by this enzyme.	Arginine	176-179	D-amino acid oxidase	Mus musculus	45-48
20567862-11	2011	Collectively, these results indicate that Arg-216 and Arg-237 play crucial and subsidiary role(s), respectively, in the substrate specificity of mouse DDO.	Arginine	42-45	D-aspartate oxidase	Mus musculus	151-154
20567862-11	2011	Collectively, these results indicate that Arg-216 and Arg-237 play crucial and subsidiary role(s), respectively, in the substrate specificity of mouse DDO.	Arginine	54-57	D-aspartate oxidase	Mus musculus	151-154
20964562-2	2011	The results showed that the 11.53, 11.70, 13.78, 13.90 and 14.07 k m/z peaks identified as native serum amyloid A (SAA), SAA with N-terminal Arg cleaved, native transthyretin (TTR) and its two variants significantly differentiated lung cancer sera from normal control sera (p &lt;0.01).	Arginine	141-144	serum amyloid A1 cluster	Homo sapiens	121-124
21205204-10	2011	These studies indicate that efficient regiospecific phosphorylation of SRSF1 is the result of a contoured binding cavity in SRPK1, a lengthy Arg-Ser repetitive segment in the RS domain, and a highly directional processing mechanism.	Arginine	141-144	serine and arginine rich splicing factor 1	Homo sapiens	71-76
21129424-0	2011	Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice.	Arginine	11-14	cholecystokinin	Mus musculus	146-149
21148395-5	2011	Here we demonstrate that rnr1 plants overaccumulate an antisense RNA, AS5, that is complementary to the 5S rRNA, its intergenic spacer, and the downstream trnR gene, which encodes tRNA(Arg), raising the possibility that AS5 destabilizes 5S rRNA or its precursor and/or blocks rRNA maturation.	Arginine	185-188	trnR	Arabidopsis thaliana	155-159
21183743-5	2011	Genetic analysis revealed a spontaneous, novel dominant CACNA1A mutation (c.4046G A, p.R1349Q) that removed a highly conserved arginine of the voltage sensing region of the P/Q-type Ca(v)2.1 channel.	Arginine	127-135	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	56-63
21234761-4	2011	XRCC1 codon 399 Arg/Gln genotype (odds ratio (OR) = 0.31, 95%CI = 0.12-0.81, p = 0.017) and 399 Gln carrier (GlnGln+Arg/Gln: OR = 0.30, 95%CI = 0.12-0.76, p = 0.01) were significantly associated with reduced susceptibility to CIHM of the CDH1 promoter.	Arginine	16-19	X-ray repair cross complementing 1	Homo sapiens	0-5
21234761-7	2011	XRCC1 codon 399 Gln/Gln genotype was significantly associated with lower mean number of CIHM when compared to the Arg/Arg genotype (1.53 +- 1.01 vs. 0.63 +- 1.06, p = 0.024).	Arginine	114-117	X-ray repair cross complementing 1	Homo sapiens	0-5
21234761-7	2011	XRCC1 codon 399 Gln/Gln genotype was significantly associated with lower mean number of CIHM when compared to the Arg/Arg genotype (1.53 +- 1.01 vs. 0.63 +- 1.06, p = 0.024).	Arginine	118-121	X-ray repair cross complementing 1	Homo sapiens	0-5
21110521-4	2011	With GIIIA, neutral replacement of the critical residue, Arg-13, allows a residual single-channel current (~30% of the unblocked, unitary amplitude) when the mutant toxin is bound to the channel and reduces the binding affinity of the toxin for Na(v)1.4 (~100-fold) [Becker, S., et al.	Arginine	57-60	immunoglobulin lambda variable 2-14	Homo sapiens	245-253
21691998-0	2011	Treatment of experimental cerebral vasospasm by protein transduction of heme oxygenase 1 (HO-1) conjugated to a residue of 11 arginines.	Arginine	126-135	heme oxygenase 1	Rattus norvegicus	72-88
21691998-0	2011	Treatment of experimental cerebral vasospasm by protein transduction of heme oxygenase 1 (HO-1) conjugated to a residue of 11 arginines.	Arginine	126-135	heme oxygenase 1	Rattus norvegicus	90-94
20093049-7	2011	RESULTS AND CONCLUSIONS: The XRCC1 homozygous wild-type genotype Arg/Arg for codon 399 was statistically less pronounced in the case subjects (21.4%) than in controls (38.5%); individuals with the variant XRCC1 genotype had a 2.3-fold increased risk for coronary atherosclerosis than individuals with the wild-type genotype (OR=2.3, 95% CI=1.13-4.69).	Arginine	65-68	X-ray repair cross complementing 1	Homo sapiens	29-34
20093049-7	2011	RESULTS AND CONCLUSIONS: The XRCC1 homozygous wild-type genotype Arg/Arg for codon 399 was statistically less pronounced in the case subjects (21.4%) than in controls (38.5%); individuals with the variant XRCC1 genotype had a 2.3-fold increased risk for coronary atherosclerosis than individuals with the wild-type genotype (OR=2.3, 95% CI=1.13-4.69).	Arginine	65-68	X-ray repair cross complementing 1	Homo sapiens	205-210
20093049-7	2011	RESULTS AND CONCLUSIONS: The XRCC1 homozygous wild-type genotype Arg/Arg for codon 399 was statistically less pronounced in the case subjects (21.4%) than in controls (38.5%); individuals with the variant XRCC1 genotype had a 2.3-fold increased risk for coronary atherosclerosis than individuals with the wild-type genotype (OR=2.3, 95% CI=1.13-4.69).	Arginine	69-72	X-ray repair cross complementing 1	Homo sapiens	29-34
20093049-7	2011	RESULTS AND CONCLUSIONS: The XRCC1 homozygous wild-type genotype Arg/Arg for codon 399 was statistically less pronounced in the case subjects (21.4%) than in controls (38.5%); individuals with the variant XRCC1 genotype had a 2.3-fold increased risk for coronary atherosclerosis than individuals with the wild-type genotype (OR=2.3, 95% CI=1.13-4.69).	Arginine	69-72	X-ray repair cross complementing 1	Homo sapiens	205-210
20364408-6	2011	We found that the combined genotype Arg/Gln-Cys/Cys of XRCC1/OGG1 (OR 3.83) as well as the Cys/Cys-Tyr/Tyr of OGG1/MUTYH (OR 6.75) increases the risk of ALL.	Arginine	36-39	X-ray repair cross complementing 1	Homo sapiens	55-60
22216286-3	2011	Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G&gt;C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP.	Arginine	157-165	ribonuclease A family member 3	Homo sapiens	66-69
22216286-3	2011	Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G&gt;C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP.	Arginine	157-165	ribonuclease A family member 3	Homo sapiens	85-91
22216286-3	2011	Single nucleotide polymorphisms (SNPs) have been described in the ECP encoding-gene (RNASE3) of which the c.371G&gt;C polymorphism (rs2073342) results in an arginine to threonine amino acid substitution p.R124T in the polypeptide and abolishes the cytotoxicity of ECP.	Arginine	157-165	ribonuclease A family member 3	Homo sapiens	264-267
22031831-9	2011	This together with an almost two-fold elevated plasma arginine level in Pept1(-/-) but not wildtype mice, suggests that a cross-talk of arginine with leptin signaling in brain, as described previously, could cause these striking effects on food intake.	Arginine	136-144	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	72-77
22073228-11	2011	CONCLUSIONS: The results of our study indicate that N-terminal arginines in positions 32, 33, 36 of KCNE1 are important for reconstitution of I(Ks).	Arginine	63-72	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	100-105
21818396-7	2011	Insulin secretion in response to pharmacological doses of GIP was preserved in GIPR(dn) transgenic mice, and serum insulin to pancreatic insulin content in response to GLP-1 and arginine was significantly higher in GIPR(dn) transgenic mice vs. controls.	Arginine	178-186	gastric inhibitory polypeptide receptor	Mus musculus	215-219
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Arginine	189-197	dynamin 1	Homo sapiens	35-44
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Arginine	189-197	dynamin 2	Homo sapiens	45-54
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Arginine	189-197	dynamin 1	Homo sapiens	59-68
21082776-4	2010	Analysis of dynamin hybrids and of dynamin 1-dynamin 2 and dynamin 1-dynamin 3 heteropolymers reveals that concentration-dependent GTPase activation is suppressed by the C-terminal proline/arginine-rich domain of dynamin 1.	Arginine	189-197	dynamin 1	Homo sapiens	59-68
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	32-40	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	42-45	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	47-50	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	47-50	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	47-50	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-5	2010	RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence interval (CI): 2.76-5.67].	Arginine	47-50	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
21157980-8	2010	ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33).	Arginine	6-9	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-5
21204315-13	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (e.g., vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	127-138
20693533-2	2010	The present work demonstrates that HOXC13, previously identified as a new member of human DNA replicative complexes, is a stable component of early replicating chromatin in living cells: it displays a slow nuclear dynamics due to its anchoring to the DNA minor groove via the arginine-5 residue of the homeodomain.	Arginine	276-284	homeobox C13	Homo sapiens	35-41
21105926-6	2010	Taking advantage of the in vivo AGD5-ARF1 interaction at the TGN, we show that mutation of an arginine residue that is critical for ARF-GAP activity of AGD5 leads to longer residence of ARF1 on the membranes, as expected if GTP hydrolysis on ARF1 was impaired due to a defective GAP.	Arginine	94-102	ARF-GAP domain 5	Arabidopsis thaliana	32-36
21105926-6	2010	Taking advantage of the in vivo AGD5-ARF1 interaction at the TGN, we show that mutation of an arginine residue that is critical for ARF-GAP activity of AGD5 leads to longer residence of ARF1 on the membranes, as expected if GTP hydrolysis on ARF1 was impaired due to a defective GAP.	Arginine	94-102	ARF-GAP domain 5	Arabidopsis thaliana	152-156
21081096-7	2010	Moreover, we suggest that residues Arg(448) and Gln(440) may be crucial for preventing insertion frameshift errors in pol mu.	Arginine	35-38	DNA polymerase mu	Homo sapiens	118-124
20815815-5	2010	In addition, we have used targeted in vitro mutagenesis to show that an Arg-Arg motif at residues 10-11 is required for proteolysis, an observation that was confirmed by functional analysis of the TS N-terminus from other mammalian species.	Arginine	72-75	APC down-regulated 1	Homo sapiens	197-199
20815815-5	2010	In addition, we have used targeted in vitro mutagenesis to show that an Arg-Arg motif at residues 10-11 is required for proteolysis, an observation that was confirmed by functional analysis of the TS N-terminus from other mammalian species.	Arginine	76-79	APC down-regulated 1	Homo sapiens	197-199
20736165-14	2010	Two functionally distinct phosphoinositide binding regions (Tyr(501)-Arg(512) and Arg(520)-Arg(552)) are present in the NHE3 F1 domain; both regions are important for serum stimulation, but they display differences in phosphoinositide binding, and the latter but not the former alters NHE3 surface expression.	Arginine	69-72	solute carrier family 9 member A3	Homo sapiens	120-124
20736165-14	2010	Two functionally distinct phosphoinositide binding regions (Tyr(501)-Arg(512) and Arg(520)-Arg(552)) are present in the NHE3 F1 domain; both regions are important for serum stimulation, but they display differences in phosphoinositide binding, and the latter but not the former alters NHE3 surface expression.	Arginine	82-85	solute carrier family 9 member A3	Homo sapiens	120-124
20956294-0	2010	Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.	Arginine	0-8	SHK1 binding protein 1	Arabidopsis thaliana	60-65
20600019-9	2010	Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect.	Arginine	52-57	dominant cataract 2	Mus musculus	37-41
21351625-7	2010	Workers with XRCC1 194 Arg/Trp genotype had more susceptibility for chromosome damage, FR = 1.13 (95% CI 1.07 - 1.27).	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	13-18
21351625-8	2010	Workers with XRCC1 280 Arg/His genotype had more susceptibility for chromosome damage, FR = 1.67 (95% CI 1.10 - 2.42).	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	13-18
21351625-9	2010	XRCC1 399 Arg/Gln and combined group of Arg/Gln and Gln/Gln genotype carrier had higher MN frequency, FR = 1.26 (95% CI 1.03 - 1.53) and 1.24 (95% CI 1.03 - 1.49) respectively.	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	0-5
21351625-9	2010	XRCC1 399 Arg/Gln and combined group of Arg/Gln and Gln/Gln genotype carrier had higher MN frequency, FR = 1.26 (95% CI 1.03 - 1.53) and 1.24 (95% CI 1.03 - 1.49) respectively.	Arginine	40-43	X-ray repair cross complementing 1	Homo sapiens	0-5
21061495-2	2004	Ligands such as vitronectin, fibronectin, etc., which interact with integrins, are known to bind these receptors through an Arg-Gly-Asp (RGD) epitope.	Arginine	124-127	vitronectin	Homo sapiens	16-27
20980600-1	2010	The Abl family nonreceptor tyrosine kinases, consisting of closely related Abl and Arg (Abl-related gene), play essential roles in mouse neurulation, but their functions in the subsequent development of CNS are poorly understood.	Arginine	83-86	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	4-7
20980600-2	2010	Here, we show that conditional deletion of Abl in precursors of neurons and glia on an Arg knock-out background leads to striking cerebellar malformations, including defects in anterior cerebellar morphogenesis, granule cell ectopia, and hypoplasia.	Arginine	87-90	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	43-46
20937909-0	2010	Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain.	Arginine	36-44	piwi like RNA-mediated gene silencing 1	Homo sapiens	56-60
20937909-1	2010	Arginine methylation modulates diverse cellular processes and represents a molecular signature of germ-line-specific Piwi family proteins.	Arginine	0-8	piwi like RNA-mediated gene silencing 1	Homo sapiens	117-121
20937909-4	2010	We find that human SND1 binds PIWIL1 in an arginine methylation-dependent manner with a preference for symmetrically dimethylated arginine.	Arginine	43-51	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	19-23
20937909-4	2010	We find that human SND1 binds PIWIL1 in an arginine methylation-dependent manner with a preference for symmetrically dimethylated arginine.	Arginine	43-51	piwi like RNA-mediated gene silencing 1	Homo sapiens	30-36
20937909-4	2010	We find that human SND1 binds PIWIL1 in an arginine methylation-dependent manner with a preference for symmetrically dimethylated arginine.	Arginine	130-138	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	19-23
20937909-4	2010	We find that human SND1 binds PIWIL1 in an arginine methylation-dependent manner with a preference for symmetrically dimethylated arginine.	Arginine	130-138	piwi like RNA-mediated gene silencing 1	Homo sapiens	30-36
20937909-6	2010	Crystal structures show that the intact SND1 extended Tudor domain forms a wide and negatively charged binding groove, which can accommodate distinct symmetrically dimethylated arginine peptides from PIWIL1 in different orientations.	Arginine	177-185	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	40-44
20937909-6	2010	Crystal structures show that the intact SND1 extended Tudor domain forms a wide and negatively charged binding groove, which can accommodate distinct symmetrically dimethylated arginine peptides from PIWIL1 in different orientations.	Arginine	177-185	piwi like RNA-mediated gene silencing 1	Homo sapiens	200-206
20606162-5	2010	To formally test this hypothesis, we generated a transgenic mouse model expressing an RPS19 mutation in which an arginine residue is replaced with a tryptophan residue at codon 62 (RPS19R62W).	Arginine	113-121	ribosomal protein S19	Mus musculus	86-91
20722419-9	2010	Gel electrophoresis analyses of plasma-derived and recombinant mutant prothrombin activation demonstrated delayed cleavage of prothrombin at both Arg(320) and Arg(271) by prothrombinase assembled with the mutant molecules, resulting in meizothrombin lingering throughout the activation process.	Arginine	146-149	coagulation factor X	Homo sapiens	171-185
20722419-9	2010	Gel electrophoresis analyses of plasma-derived and recombinant mutant prothrombin activation demonstrated delayed cleavage of prothrombin at both Arg(320) and Arg(271) by prothrombinase assembled with the mutant molecules, resulting in meizothrombin lingering throughout the activation process.	Arginine	159-162	coagulation factor X	Homo sapiens	171-185
20854963-1	2010	Evidence from multiple large prospective studies suggests that a common polymorphism that encodes an arginine (Arg)-to-tryptophan substitution at position 719 in the KIF6 gene is associated with coronary heart disease (CHD) and reduction in coronary events from statin therapy.	Arginine	101-109	kinesin family member 6	Homo sapiens	166-170
20854963-1	2010	Evidence from multiple large prospective studies suggests that a common polymorphism that encodes an arginine (Arg)-to-tryptophan substitution at position 719 in the KIF6 gene is associated with coronary heart disease (CHD) and reduction in coronary events from statin therapy.	Arginine	111-114	kinesin family member 6	Homo sapiens	166-170
20804738-3	2010	Upon T- or B-cell receptor engagement human (h) A20 is cleaved by MALT1 after arginine 439, yielding an N-terminal fragment (hA20p50) and a C-terminal one (hA20p37).	Arginine	78-86	immunoglobulin kappa variable 1-27	Homo sapiens	48-51
20737438-4	2010	Loss of Abl function reduces FA, F-actin, and phosphorylated myosin light chain (pMLC) staining at the cell periphery, shifting the distribution of these elements more to the center of the cell than in wild-type (WT) and arg(-/-) cells.	Arginine	221-224	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	8-11
20737438-6	2010	Abl/Arg-dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation.	Arginine	4-7	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-3
20835242-4	2010	Here we report the crystal structures of the UBR boxes of the human N-recognins UBR1 and UBR2, alone and in complex with an N-end rule peptide, Arg-Ile-Phe-Ser.	Arginine	144-147	ubiquitin protein ligase E3 component n-recognin 1	Homo sapiens	80-84
20857533-5	2010	RESULTS: In the acute pancreatitis model, among five time points at which plasmas were sampled, miR-216a concentrations were significantly elevated 24 h after arginine administration and remained significantly increased until 48 h after operation (compared with 0 h time point, P &lt; 0.01, Kruskal-Wallis Test).	Arginine	159-167	microRNA 216a	Rattus norvegicus	96-104
20592031-3	2010	We have solved the crystallographic structures of CT ArtJ and CPn ArtJ, which are found to display a type II transporter fold organized in two alpha-beta domains with the arginine-binding region at their interface.	Arginine	171-179	carboxypeptidase N subunit 1	Homo sapiens	62-65
20945564-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
20615869-7	2010	For the orientation of hypoxanthine with C-2 proximal to the molybdenum center, the disposition of substrate in the active site is such that Arg(880) and Glu(802), previous shown to be catalytically important for the conversion of xanthine to uric acid, play similar roles in hydroxylation at C-2 as at C-8.	Arginine	141-144	complement C2	Bos taurus	41-44
20615869-7	2010	For the orientation of hypoxanthine with C-2 proximal to the molybdenum center, the disposition of substrate in the active site is such that Arg(880) and Glu(802), previous shown to be catalytically important for the conversion of xanthine to uric acid, play similar roles in hydroxylation at C-2 as at C-8.	Arginine	141-144	complement C2	Bos taurus	293-296
20541591-8	2010	CONCLUSION: Protein arginine dimethylations of hnRNPR, CstF-64, and TPI were regulated during HeLa cell cycle by respective PRMTs.	Arginine	20-28	cleavage stimulation factor subunit 2	Homo sapiens	55-62
20541591-9	2010	GENERAL SIGNIFICANCE: These results suggest that regulation of arginine dimethylation of hnRNPR, CstF-64, and TPI at G0/G1 to G1 are most likely to modulate the cellular growth and proliferation in HeLa cell cycle.	Arginine	63-71	cleavage stimulation factor subunit 2	Homo sapiens	97-104
20664961-2	2010	It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor.	Arginine	75-83	Fc gamma receptor IIIa	Homo sapiens	115-127
20664961-2	2010	It has also been linked with the change of leucine (L) to histidine (H) or arginine (R) at amino acid position 48 (FcgammaRIIIa-48L/R/H) in the CD16a receptor.	Arginine	75-83	Fc gamma receptor IIIa	Homo sapiens	144-149
20573782-4	2010	Our results suggest that this network involves the cluster of residues Arg(188) in TM2, Gln(380) in TM7, and Asn(229) in TM3.	Arginine	71-74	tropomyosin 3	Homo sapiens	121-124
20666457-4	2010	Herein, we report a type of compound that blocks PRMT1-mediated arginine methylation at micromolar potency through a unique mechanism.	Arginine	64-72	protein arginine methyltransferase 1	Homo sapiens	49-54
20600126-2	2010	Peptide agonists of the MC4R are characterized by the conserved sequence His(6)-Phe(7)-Arg(8)-Trp(9), which is crucial for their interaction with the receptor.	Arginine	87-90	melanocortin 4 receptor	Homo sapiens	24-28
20652227-8	2010	The study on XRCC1 399 Arg/gln polymorphism in petrol pump workers demonstrated very less difference in allele frequency compared to controls.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	13-18
20797320-4	2010	Sequence analysis indicated that two residues, Gly156 in the AP2 domain and Phe62 at the N-terminal domain were mutated to arginine and serine, respectively.	Arginine	123-131	floral homeotic protein APETALA 2	Brassica napus	61-64
20150913-2	2010	This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3.	Arginine	50-53	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	22-27
20150913-2	2010	This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3.	Arginine	50-53	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	24-27
20150913-3	2010	The SH (Src homology)3 domains of c-Abl/Arg bind to a P(80)GPPSGP motif of Gal3, and Tyr79 and Tyr118 are the major tyrosine phosphorylation sites.	Arginine	40-43	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-39
20562214-0	2010	Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. Mammalian cleavage factor I (CF I(m)) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF I(m)25, CF I(m)59, CF I(m)68).	Arginine	0-8	nudix hydrolase 21	Homo sapiens	189-198
20562214-0	2010	Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. Mammalian cleavage factor I (CF I(m)) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF I(m)25, CF I(m)59, CF I(m)68).	Arginine	0-8	cleavage and polyadenylation specific factor 7	Homo sapiens	200-209
20435140-0	2010	Novel vitamin D receptor ligands having a carboxyl group as an anchor to arginine 274 in the ligand-binding domain.	Arginine	73-81	vitamin D receptor	Homo sapiens	6-24
20435140-3	2010	The X-ray crystal structure of human VDR in complex with 1alpha,25-dihydroxyvitamin D3 (1) shows that, together with Ser-237, the 1alpha-hydroxyl group of 1alpha,25-dihydroxyvitamin D3 (1) makes hydrogen bonds with Arg-274, single mutation of which results in impaired ligand recognition.	Arginine	215-218	vitamin D receptor	Homo sapiens	37-40
20435140-5	2010	We speculated that the carboxylic acid of lithocholic acid could be recognized by Arg-274 in the ligand-binding domain of VDR.	Arginine	82-85	vitamin D receptor	Homo sapiens	122-125
20395299-5	2010	Replacement of Val(362) with amino acid residues that disrupt the alpha-helical structure predicted by molecular modeling, such as arginine, glutamate, or phenylalanine, attenuated the stimulatory effects of Cx50 on lens differentiation, whereas replacement with threonine, isoleucine, leucine, or proline, which maintain the structure preserved the function of Cx50.	Arginine	131-139	gap junction protein alpha 8	Gallus gallus	208-212
20215577-0	2010	L-arginine restores endothelial nitric oxide synthase-coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	20-53
20215577-8	2010	L-arginine increased eNOS expression, phosphorylation of eNOS at Ser(1177), and association of eNOS and HSP90 without significantly altering HSP90 expression.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	21-25
20215577-8	2010	L-arginine increased eNOS expression, phosphorylation of eNOS at Ser(1177), and association of eNOS and HSP90 without significantly altering HSP90 expression.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	57-61
20215577-8	2010	L-arginine increased eNOS expression, phosphorylation of eNOS at Ser(1177), and association of eNOS and HSP90 without significantly altering HSP90 expression.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	57-61
20215577-9	2010	L-arginine may act through three pathways, providing a substrate for NO generation, preserving eNOS expression/phosphorylation, and maintaining the association of eNOS and HSP90, which allows restoration of eNOS activity and coupling activity, to maintain the balance between NO and O(2)(*-) and delay the development of PH.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	95-99
20215577-9	2010	L-arginine may act through three pathways, providing a substrate for NO generation, preserving eNOS expression/phosphorylation, and maintaining the association of eNOS and HSP90, which allows restoration of eNOS activity and coupling activity, to maintain the balance between NO and O(2)(*-) and delay the development of PH.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	163-167
20215577-9	2010	L-arginine may act through three pathways, providing a substrate for NO generation, preserving eNOS expression/phosphorylation, and maintaining the association of eNOS and HSP90, which allows restoration of eNOS activity and coupling activity, to maintain the balance between NO and O(2)(*-) and delay the development of PH.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	163-167
19913547-4	2010	Mutant subunits with this arginine substitution generated no or barely detectable currents in a homotetrameric condition, but did generate I(Ks)-like currents in association with hKCNE1.	Arginine	26-34	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	179-185
20129943-0	2010	Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.	Arginine	0-8	nuclear RNA export factor 1	Homo sapiens	71-74
20129943-0	2010	Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.	Arginine	0-8	nuclear RNA export factor 1	Homo sapiens	75-79
20129943-1	2010	The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain.	Arginine	54-62	Aly/REF export factor	Homo sapiens	8-11
20129943-1	2010	The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain.	Arginine	54-62	nuclear RNA export factor 1	Homo sapiens	38-41
20129943-1	2010	The REF/ALY mRNA export adaptor binds TAP/NXF1 via an arginine-rich region, which overlaps with its RNA-binding domain.	Arginine	54-62	nuclear RNA export factor 1	Homo sapiens	42-46
20129943-4	2010	We have mapped the arginine methylation sites of REF using mass spectrometry and find that several arginines within the TAP and RNA binding domains are methylated in vivo.	Arginine	19-27	nuclear RNA export factor 1	Homo sapiens	120-123
20129943-4	2010	We have mapped the arginine methylation sites of REF using mass spectrometry and find that several arginines within the TAP and RNA binding domains are methylated in vivo.	Arginine	99-108	nuclear RNA export factor 1	Homo sapiens	120-123
20571112-5	2010	In addition, HopF2 Arg-71 and Asp-175 residues that are required for the interaction with MKK5 are also necessary for blocking MAP kinase activation, PAMP-triggered defenses, and virulence function in plants.	Arginine	19-22	MAP kinase kinase 5	Arabidopsis thaliana	90-94
20571112-7	2010	Arg-313 of MKK5 is required for ADP-ribosylation by HopF2 and MKK5 function in the plant cell.	Arginine	0-3	MAP kinase kinase 5	Arabidopsis thaliana	11-15
20571112-7	2010	Arg-313 of MKK5 is required for ADP-ribosylation by HopF2 and MKK5 function in the plant cell.	Arginine	0-3	MAP kinase kinase 5	Arabidopsis thaliana	62-66
20184876-3	2010	Agmatine, the metabolite of arginine by arginine decarboxylase, is suggested to be a neuroprotective agent.	Arginine	28-36	antizyme inhibitor 2	Rattus norvegicus	40-62
20394361-0	2010	Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.	Arginine	11-19	complement factor H	Homo sapiens	150-158
20334431-9	2010	The dTDP moiety is anchored to the protein via the side chains of Glu 113, Gln 254, and Arg 330.	Arginine	88-91	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	4-8
20019240-4	2010	The largest difference between p53-arginine and p53-proline was found with the PERP gene involved in cell-cell adhesion and apoptosis.	Arginine	35-43	p53 apoptosis effector related to PMP22	Homo sapiens	79-83
20064924-0	2010	Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA.	Arginine	0-9	fragile X messenger ribonucleoprotein 1	Mus musculus	34-38
20064924-2	2010	FMRP is an RNA-binding protein that is highly expressed in neurons and undergoes multiple post-translational modifications including methylation on arginine.	Arginine	148-156	fragile X messenger ribonucleoprotein 1	Mus musculus	0-4
20064924-4	2010	To identify the arginines important for FMRP function, we examined their role in polyribosome and mRNA association.	Arginine	16-25	fragile X messenger ribonucleoprotein 1	Mus musculus	40-44
20064924-5	2010	We found that arginines 533 and 538 were required for normal FMRP polyribosome association whereas all four arginines played a role in RNA binding, depending on the identity of the RNA.	Arginine	14-23	fragile X messenger ribonucleoprotein 1	Mus musculus	61-65
20064924-6	2010	The model G-quadruplex RNA sc1 required arginines 533 and 538 for normal association with FMRP, whereas AATYK mRNA did not.	Arginine	40-49	fragile X messenger ribonucleoprotein 1	Mus musculus	90-94
20064924-7	2010	In vitro methylation of FMRP-bearing arginine substitutions inhibited sc1 binding but not AATYK binding.	Arginine	37-45	fragile X messenger ribonucleoprotein 1	Mus musculus	24-28
20053728-5	2010	Importantly, the defects in Npl3p and Tho2p recruitment, antitermination and elongation in hmt1Delta cells all were mitigated by substitutions in Npl3p RGG repeats that functionally mimic arginine methylation by Hmt1p.	Arginine	188-196	Tho2p	Saccharomyces cerevisiae S288C	38-43
20053728-5	2010	Importantly, the defects in Npl3p and Tho2p recruitment, antitermination and elongation in hmt1Delta cells all were mitigated by substitutions in Npl3p RGG repeats that functionally mimic arginine methylation by Hmt1p.	Arginine	188-196	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	146-151
20111005-3	2010	The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta.	Arginine	12-20	coactivator associated arginine methyltransferase 1	Homo sapiens	41-46
20111005-3	2010	The protein arginine methyltransferase 4 PRMT4/CARM1 interacts with C/EBPbeta and dimethylates a conserved arginine residue (R3) in the C/EBPbeta N-terminal transactivation domain, as identified by mass spectrometry of cell-derived C/EBPbeta.	Arginine	12-20	coactivator associated arginine methyltransferase 1	Homo sapiens	47-52
20184307-2	2010	Radiolabeled RGD (Arg-Gly-Asp) peptides that specifically target integrin alphavbeta3 have great potential for tumor early detection and noninvasively monitoring the status of tumor angiogenesis.	Arginine	18-21	integrin subunit alpha V	Homo sapiens	65-85
19935701-8	2010	In addition, lysine 96 residue is essential for ING3 ubiquitination as its mutation to arginine dramatically abrogated ING3 degradation.	Arginine	87-95	inhibitor of growth family member 3	Homo sapiens	48-52
19937853-0	2010	Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3.	Arginine	17-25	caspase 3	Mus musculus	113-122
20018880-5	2010	CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis.	Arginine	23-31	choline phosphotransferase 1	Homo sapiens	0-4
20018880-5	2010	CPT1 mutants harboring arginine substitutions at multiple carboxyl-terminal lysines exhibited proteolytic resistance to effects of LPCAT1 overexpression in cells and restored de novo PtdCho synthesis.	Arginine	23-31	lysophosphatidylcholine acyltransferase 1	Homo sapiens	131-137
21182780-7	2010	RESULTS: In total about two-thirds of the 81 arginines of human fibrinogen were found to be susceptible to citrullination by the human PAD2, the human PAD4 or the rabbit PAD2 enzymes.	Arginine	45-54	peptidyl arginine deiminase 2	Homo sapiens	135-139
21182780-7	2010	RESULTS: In total about two-thirds of the 81 arginines of human fibrinogen were found to be susceptible to citrullination by the human PAD2, the human PAD4 or the rabbit PAD2 enzymes.	Arginine	45-54	peptidyl arginine deiminase 2	Homo sapiens	170-174
19486361-7	2010	RESULTS: The frequencies of ADH2 Arg/His genotype and of ADH2 His allele were significantly lower in patients with migraine when compared with those of controls, and were unrelated with the age of onset of migraine attacks, family history of migraine or presence of aura.	Arginine	33-36	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	28-32
19486361-9	2010	CONCLUSION: The results of the present study suggest that ADH2 Arg/His genotype should be associated with a decreased risk for migraine, while the ADH2 His allelic variant should be related with the risk for triggering migraine attacks after alcohol consumption in our population of migraine patients.	Arginine	63-66	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	58-62
19858193-1	2010	Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	64-67	coagulation factor X	Homo sapiens	0-14
19858193-1	2010	Prothrombinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271).	Arginine	97-100	coagulation factor X	Homo sapiens	0-14
19858193-2	2010	Exosite-dependent binding of prothrombin to prothrombinase facilitates active site docking by Arg(320) and initial cleavage at this site.	Arginine	94-97	coagulation factor X	Homo sapiens	44-58
19858193-4	2010	However, mutation of Arg(320) to Gln reveals that prothrombinase can cleave prothrombin following Arg side chains shifted by as many as two residues N-terminal to the 320 position at near normal rates.	Arginine	21-24	coagulation factor X	Homo sapiens	50-64
20853600-1	2010	Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) is the key enzyme in urea synthesis, hydrolyzing L-arginine into L-ornithine and urea.	Arginine	10-20	arginase 2	Homo sapiens	0-8
20853600-2	2010	Arginase modulates levels of nitric oxide, creatine, and creatinine, likely by regulating intracellular L-arginine availability.	Arginine	104-114	arginase 2	Homo sapiens	0-8
20062922-6	2010	An A2 epitope, not overlapping the common A2 epitope, was identified and the antibody was shown to enhance thrombin (and FXa)-catalysed activation of FVIII by modestly accelerating cleavage at Arg(372).	Arginine	193-196	coagulation factor X	Homo sapiens	121-124
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	153-156	coactivator associated arginine methyltransferase 1	Homo sapiens	0-51
19843527-1	2009	Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg(17) and Arg(26) of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein-binding protein.	Arginine	153-156	coactivator associated arginine methyltransferase 1	Homo sapiens	53-58
19949292-0	2009	Arginine methylation as a molecular signature of the Piwi small RNA pathway.	Arginine	0-8	piwi like RNA-mediated gene silencing 1	Homo sapiens	53-57
20641262-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
20641458-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
20641743-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Mus musculus	121-132
20641917-5	2004	The peptide sequence Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	21-24	vitronectin	Homo sapiens	121-132
19800676-4	2009	METHODS: Arg/Gly status at position 16 of ADRB2 was assessed in 1182 young asthmatic patients (age, 3-22 years) from Scotland.	Arginine	9-12	adrenoceptor beta 2	Homo sapiens	42-47
19793817-4	2009	Here we show that this NES contains several small arginine-rich domains that cooperate to allow efficient interaction with TAP/NXF1.	Arginine	50-58	nuclear RNA export factor 1	Homo sapiens	123-126
19793817-4	2009	Here we show that this NES contains several small arginine-rich domains that cooperate to allow efficient interaction with TAP/NXF1.	Arginine	50-58	nuclear RNA export factor 1	Homo sapiens	127-131
19887642-4	2009	Substitution of Arg for these residues confers Vif resistance and restores A3G"s antiviral activity in the presence of Vif.	Arginine	16-19	Vif	Human immunodeficiency virus 1	47-50
19887642-4	2009	Substitution of Arg for these residues confers Vif resistance and restores A3G"s antiviral activity in the presence of Vif.	Arginine	16-19	Vif	Human immunodeficiency virus 1	119-122
19783390-5	2009	Among the three, one de novo SCN2A mutation (c.3935G&gt;C: R1312T) identified in a patient was thought to affect an arginine residue in a voltage sensor of the channel and hence, to be pathogenic.	Arginine	116-124	sodium voltage-gated channel alpha subunit 2	Homo sapiens	29-34
19723515-7	2009	DNA sequence analysis revealed the subject to be a homozygote for a novel ABCA1 mutation c.4121C&gt;T, which changes arginine 1270 to a stop codon (R1270X).	Arginine	117-125	ATP binding cassette subfamily A member 1	Homo sapiens	74-79
19819978-5	2009	Substitution of these lysines by arginines in TRalpha decreased ligand binding affinity and precluded ligand-dependent release of corepressors and recruitment of coactivators.	Arginine	33-42	T cell receptor alpha locus	Homo sapiens	46-53
19874399-6	2009	Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P= 0.0212).	Arginine	49-52	MDM2 proto-oncogene	Homo sapiens	112-116
19874399-6	2009	Interestingly, the combination of the homozygous Arg/Arg genotype of p53 codon 72 and homozygous GG genotype of MDM2 SNP309 polymorphisms was significantly associated with the risk of endometrial cancer (odds ratio = 3.28, 95% confidence interval = 1.13 to 9.53, P= 0.0212).	Arginine	53-56	MDM2 proto-oncogene	Homo sapiens	112-116
19847369-7	2009	Taken together, our results suggest that apelin has a prophylactic effect against hypoxic pulmonary hypertension in rats, and that the mechanism of this effect is possibly associated with activation of the L-Arg/NOS /NO pathway.	Arginine	206-211	apelin	Rattus norvegicus	41-47
19523989-8	2009	Furthermore, the N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain can be excised by DPPIV and recombinant peptidase with DPPIV-like activities.	Arginine	28-31	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-40
19523989-8	2009	Furthermore, the N-terminal Arg-4, Pro-3, Lys-2, Pro-1extension at insulin B-chain can be excised by DPPIV and recombinant peptidase with DPPIV-like activities.	Arginine	28-31	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	Homo sapiens	42-47
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	carboxypeptidase B1	Homo sapiens	21-39
19790060-3	2009	Thrombin-activatable carboxypeptidase B (CPB), also called thrombin-activatable fibrinolysis inhibitor, removes the C-terminal arginine from OPN-R, generating OPN-L and abrogating its enhanced cell binding.	Arginine	127-135	carboxypeptidase B1	Homo sapiens	41-44
19805281-3	2009	By site-directed mutagenesis in human Polmu, we have identified a specific DNA ligand residue (Arg(387)) that is responsible for its limited terminal transferase activity compared to that of human TdT, its closest homologue (42% amino acid identity).	Arginine	95-98	DNA polymerase mu	Homo sapiens	38-43
19805281-3	2009	By site-directed mutagenesis in human Polmu, we have identified a specific DNA ligand residue (Arg(387)) that is responsible for its limited terminal transferase activity compared to that of human TdT, its closest homologue (42% amino acid identity).	Arginine	95-98	DNA nucleotidylexotransferase	Homo sapiens	141-161
19805281-3	2009	By site-directed mutagenesis in human Polmu, we have identified a specific DNA ligand residue (Arg(387)) that is responsible for its limited terminal transferase activity compared to that of human TdT, its closest homologue (42% amino acid identity).	Arginine	95-98	DNA nucleotidylexotransferase	Homo sapiens	197-200
19596859-6	2009	A single point mutation in the catalytic domain of GDE3 (GDE3R231A) leads to loss of GroPIns enzymatic hydrolysis, identifying an arginine residue crucial for GDE3 activity.	Arginine	130-138	glycerophosphodiester phosphodiesterase domain containing 2	Homo sapiens	51-55
19596859-6	2009	A single point mutation in the catalytic domain of GDE3 (GDE3R231A) leads to loss of GroPIns enzymatic hydrolysis, identifying an arginine residue crucial for GDE3 activity.	Arginine	130-138	glycerophosphodiester phosphodiesterase domain containing 2	Homo sapiens	57-66
19596859-6	2009	A single point mutation in the catalytic domain of GDE3 (GDE3R231A) leads to loss of GroPIns enzymatic hydrolysis, identifying an arginine residue crucial for GDE3 activity.	Arginine	130-138	glycerophosphodiester phosphodiesterase domain containing 2	Homo sapiens	57-61
19586904-9	2009	The results presented above led us to propose that NOS mediates UV-induced eIF2alpha phosphorylation by activation of both PERK and GCN2 via oxidative stress and l-arginine starvation signaling pathways.	Arginine	162-172	eukaryotic translation initiation factor 2 alpha kinase 4	Homo sapiens	132-136
19725955-6	2009	Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.	Arginine	0-3	catenin (cadherin associated protein), beta 1	Mus musculus	67-79
19725955-6	2009	Arg-methylation of Sox9 by CARM1 disrupts interaction of Sox9 with beta-catenin, regulating Cyclin D1 expression and cell cycle progression of chondrocytes.	Arginine	0-3	cyclin D1	Mus musculus	92-101
19694644-0	2009	Plasma C3a-des-Arg levels in women with and without endometriosis.	Arginine	15-18	complement C3	Homo sapiens	7-10
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	108-112
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19558213-7	2009	The combined genotype of heterozygous arginine (Arg)/proline (Pro), Pro/Pro, and slow acetylator alleles of NAT2*5 and NAT2*6 showed higher, although not significant, risk of lung cancer compared with Arg/Arg and rapid acetylator alleles of NAT2*5 and NAT2*6.	Arginine	201-204	N-acetyltransferase 2	Homo sapiens	119-123
19449376-6	2009	Among heavy drinkers, the ADH1B Arg/Arg (55 years) and ALDH2 Glu/Lys genotypes (54 years) were found to confer a 15 and 16 years earlier carcinoma diagnosed age than His/His and Glu/Glu nondrinkers (both 70 years), respectively.	Arginine	32-35	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
19449376-6	2009	Among heavy drinkers, the ADH1B Arg/Arg (55 years) and ALDH2 Glu/Lys genotypes (54 years) were found to confer a 15 and 16 years earlier carcinoma diagnosed age than His/His and Glu/Glu nondrinkers (both 70 years), respectively.	Arginine	36-39	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	26-31
19449376-7	2009	For drinkers, 1-year age advancement was, separately, associated with a 0.977 and 0.953-fold stepwise reduced likelihood of being ADH1B Arg homozygote and ALDH2 Lys variant.	Arginine	136-139	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	130-135
19449376-9	2009	In smokers, appreciably higher cumulative cancer onset risks were correspondingly recognized from the age of 45 and 49 upward among any + Lys allele and Arg/Arg + Glu/Glu combined-ADH1B/ALDH2-genotype drinkers than nondrinkers.	Arginine	153-156	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	180-185
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	93-96	coagulation factor X	Homo sapiens	0-9
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	105-108	coagulation factor X	Homo sapiens	0-9
19581306-7	2009	Factor Xa and thrombin directly cleaved the propeptide on the carboxyl terminal sides of the Arg(98) and Arg(101) residues, whereas plasmin only cleaved the propeptide downstream of Arg(101).	Arginine	105-108	coagulation factor X	Homo sapiens	0-9
19654310-5	2009	Here, we show that the Arg-to-Gln substitution profoundly impairs the ability of LOX-PP to inhibit the invasive phenotype and tumor formation of NF639 cells in a xenograft model.	Arginine	23-26	lysyl oxidase	Homo sapiens	81-84
19172319-5	2009	However, detailed comparison of our modeled structure of ZPI/FXa with that of AT3/FXa points to differences in interaction specificity at the reactive center and in the stability of the inhibitory complex, due to the presence of a tyrosine residue at the P1 position in ZPI, instead of the P1 arginine residue in AT3.	Arginine	293-301	coagulation factor X	Homo sapiens	61-64
19172319-5	2009	However, detailed comparison of our modeled structure of ZPI/FXa with that of AT3/FXa points to differences in interaction specificity at the reactive center and in the stability of the inhibitory complex, due to the presence of a tyrosine residue at the P1 position in ZPI, instead of the P1 arginine residue in AT3.	Arginine	293-301	coagulation factor X	Homo sapiens	82-85
19497050-5	2009	Various biochemical assays showed that the N-terminus of Calnuc interacts with an arginine-rich region in the cytosolic tail of LRP9.	Arginine	82-90	sortilin related receptor 1	Homo sapiens	128-132
19477182-2	2009	The prototypical SR protein ASF/SF2 (human alternative splicing factor) contains two N-terminal RNA recognition motifs (RRMs) (RRM1 and RRM2) and a 50-residue C-terminal RS (arginine-serine-rich) domain that can be phosphorylated at numerous serines by the protein kinase SR-specific protein kinase (SRPK) 1.	Arginine	174-182	serine and arginine rich splicing factor 1	Homo sapiens	28-35
19602623-4	2009	We have identified the Arabidopsis thaliana gene that codes for tRNA adenosine deaminase arginine (TADA), a chloroplast tRNA editing protein specifically required for deamination of chloroplast (cp)-tRNAArg(ACG) to cp-tRNAArg(ICG).	Arginine	89-97	tRNA arginine adenosine deaminase	Arabidopsis thaliana	99-103
19250953-5	2009	Among the 16 peptide drugs possessing different isoelectric points, it was observed that only gastrin, insulin and glucagon-like peptide-1 (GLP-1) bound to D-R8 (D-form arginine octamer, a typical CPP), and subsequently their intestinal absorption increased by coadministration of D-R8.	Arginine	169-177	gastrin	Rattus norvegicus	94-101
19250953-5	2009	Among the 16 peptide drugs possessing different isoelectric points, it was observed that only gastrin, insulin and glucagon-like peptide-1 (GLP-1) bound to D-R8 (D-form arginine octamer, a typical CPP), and subsequently their intestinal absorption increased by coadministration of D-R8.	Arginine	169-177	glucagon	Rattus norvegicus	115-138
19250953-5	2009	Among the 16 peptide drugs possessing different isoelectric points, it was observed that only gastrin, insulin and glucagon-like peptide-1 (GLP-1) bound to D-R8 (D-form arginine octamer, a typical CPP), and subsequently their intestinal absorption increased by coadministration of D-R8.	Arginine	169-177	glucagon	Rattus norvegicus	140-145
19409905-1	2009	N-Acetyl-L-glutamate kinase (NAGK) catalyzes the first committed step in arginine biosynthesis in organisms that perform the cyclic pathway of ornithine synthesis.	Arginine	73-81	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	29-33
19409905-6	2009	The non-conserved C-terminus of S. elongatus NAGK was identified as an element, which strongly enhances arginine inhibition and is responsible for most of the differences between S. elongatus and A. thaliana NAGK with respect to arginine sensitivity.	Arginine	104-112	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	45-49
19409905-6	2009	The non-conserved C-terminus of S. elongatus NAGK was identified as an element, which strongly enhances arginine inhibition and is responsible for most of the differences between S. elongatus and A. thaliana NAGK with respect to arginine sensitivity.	Arginine	229-237	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	45-49
19409905-6	2009	The non-conserved C-terminus of S. elongatus NAGK was identified as an element, which strongly enhances arginine inhibition and is responsible for most of the differences between S. elongatus and A. thaliana NAGK with respect to arginine sensitivity.	Arginine	229-237	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	208-212
19430315-4	2009	RESULTS: UGT1A7 codon 208 Arg carriers exhibited significantly higher CBMN frequencies than did the Trp/Trp (P &lt; 0.05).	Arginine	26-29	UDP glucuronosyltransferase family 1 member A7	Homo sapiens	9-15
20540537-1	2009	Radiolabeled RGD (Arg-Gly-Asp) and bombesin (BBN) radiotracers that specifically target integrin alpha(v)beta(3) and gastrin releasing peptide receptor (GRPR) are both promising radiopharmaceuticals for tumor imaging.	Arginine	18-21	integrin subunit alpha V	Homo sapiens	88-112
19407395-1	2009	Human ADP-ribosylhydrolase 1 (hARH1, ADPRH) cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein.	Arginine	101-104	ADP-ribosylarginine hydrolase	Homo sapiens	30-35
18946634-6	2009	Allelic frequencies in wild type of XRCC1 C26304T were 91.1% C(Arg); G27466A 62.9% G(Arg); G23591A 60.3% G(Arg); APE1 T2197G 75.1% T(Asp) and XPD A35931C 71.8% A(Lys).	Arginine	63-66	X-ray repair cross complementing 1	Homo sapiens	36-41
19377467-0	2009	Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.	Arginine	0-8	Argonaute 3	Drosophila melanogaster	74-78
19377467-5	2009	We report that the Drosophila homologue of protein methyltransferase 5 (dPRMT5, csul/dart5), which is also the product of a grandchildless gene, is required for arginine methylation of Drosophila Piwi, Ago3 and Aub proteins in vivo.	Arginine	161-169	Argonaute 3	Drosophila melanogaster	202-206
19416632-8	2009	Treating healthy rats with NO2-Arg-Trim resulted in a dose-dependent attenuation of CRD-induced nociception and in an inhibition of CRD-induced overexpression of spinal cFOS mRNA.	Arginine	31-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	169-173
19365714-9	2009	The immunoblotting results of immunoprecipitated hnRNP I and NonO protein are consistent with arginine methylation in both proteins.	Arginine	94-102	polypyrimidine tract binding protein 1	Homo sapiens	49-56
19280628-8	2009	XRCC1 Arg/Arg and XRCC3 Thr/Met genotypes combined were associated with an OR of 2.38 (95% CI, 1.24-4.55).	Arginine	6-9	X-ray repair cross complementing 1	Homo sapiens	0-5
19280628-8	2009	XRCC1 Arg/Arg and XRCC3 Thr/Met genotypes combined were associated with an OR of 2.38 (95% CI, 1.24-4.55).	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	0-5
19280628-9	2009	The XRCC1 Arg/Gln and XRCC3 Thr/Thr, Thr/Met, and Met/Met genotypes had ORs of 1.88 (95% CI, 1.02-4.10), 1.97 (95% CI, 1.05-3.73), and 4.13 (95% CI, 1.50-11.33), respectively.	Arginine	10-13	X-ray repair cross complementing 1	Homo sapiens	4-9
19280628-11	2009	Similarly, XRCC1 Arg/Gln together with XPC Lys/Lys was found to significantly increase the risk of HD (OR, 2.14; 95% CI, 1.09-4.23).	Arginine	17-20	X-ray repair cross complementing 1	Homo sapiens	11-16
19461900-7	2009	Some subgroups of asthmatics also seem to respond to anticholinergic drugs: among them, those with the Arg/Arg genotype for the beta2-adrenergic receptor and those with a high percentage of neutrophils in sputum.	Arginine	103-106	adrenoceptor beta 2	Homo sapiens	128-153
19461900-7	2009	Some subgroups of asthmatics also seem to respond to anticholinergic drugs: among them, those with the Arg/Arg genotype for the beta2-adrenergic receptor and those with a high percentage of neutrophils in sputum.	Arginine	107-110	adrenoceptor beta 2	Homo sapiens	128-153
19188358-8	2009	Arginine activated an Efg1p-dependent yeast-to-hypha switch, enabling wild-type C. albicans and KWN8 to escape from macrophages within 6 h, whereas KWN6 was defective in this regard.	Arginine	0-8	Efg1p	Saccharomyces cerevisiae S288C	22-27
19290927-7	2009	Abl/Arg double null T cells exhibit impaired TCR-induced signaling, proliferation, and cytokine production.	Arginine	4-7	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	0-3
19225614-1	2009	A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.	Arginine	269-277	integrin subunit alpha V	Homo sapiens	237-261
19447371-1	2009	The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)(2) and PP(Arg)(2).	Arginine	187-190	translocator protein	Homo sapiens	65-99
19447371-1	2009	The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)(2) and PP(Arg)(2).	Arginine	187-190	translocator protein	Homo sapiens	101-104
19447371-1	2009	The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)(2) and PP(Arg)(2).	Arginine	202-205	translocator protein	Homo sapiens	65-99
19447371-1	2009	The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)(2) and PP(Arg)(2).	Arginine	202-205	translocator protein	Homo sapiens	101-104
19447371-5	2009	The highest affinity toward PBR showed PPIX and Hp, Hp(Arg)(2), PP(Arg)(2) lower, respectively.	Arginine	55-58	translocator protein	Homo sapiens	28-31
19447371-5	2009	The highest affinity toward PBR showed PPIX and Hp, Hp(Arg)(2), PP(Arg)(2) lower, respectively.	Arginine	67-70	translocator protein	Homo sapiens	28-31
20104979-3	2009	METHODS: From March 1, 2005 to December 31, 2008, the polymerase chain reaction-restriction fragment length polymorphism method was applied to evaluate genetic polymorphisms of the XRCC1 codon399 (Arg/Gln) and XPD codon751 (Lys/Gln) DNA repair genes in 108 patients with stage IIIB and IV NSCLCs treated with platinum-based chemotherapy in the Department of Chemotherapy of Jiangsu Cancer Hospital and Research Institute.	Arginine	197-200	X-ray repair cross complementing 1	Homo sapiens	181-186
19462932-1	2009	OBJECTIVE: To determine the Km, Vmax, and Ki of BOC-Leu-Ser-Thr-Arg-pNA (B3644) in the determination of kallikrein, and then to establish the procedure for plasma prekallikrein/kallikrein determination.	Arginine	64-67	kallikrein related peptidase 4	Homo sapiens	104-114
19462932-1	2009	OBJECTIVE: To determine the Km, Vmax, and Ki of BOC-Leu-Ser-Thr-Arg-pNA (B3644) in the determination of kallikrein, and then to establish the procedure for plasma prekallikrein/kallikrein determination.	Arginine	64-67	kallikrein related peptidase 4	Homo sapiens	166-176
19480914-9	2009	We speculate that charge repulsion between arginines 23 and 43 destabilizes the chemokine fold and promotes conversion to the novel lymphotactin dimer, whereas binding of chloride or another anion stabilizes the chemokine fold by neutralizing the repulsive effect.	Arginine	43-52	X-C motif chemokine ligand 1	Homo sapiens	132-144
19008859-6	2008	These RPEL(MAL):G-actin structures explain the sequence conservation defining the RPEL motif, including the invariant arginine.	Arginine	118-126	phosphatase and actin regulator 1	Homo sapiens	6-10
19008859-6	2008	These RPEL(MAL):G-actin structures explain the sequence conservation defining the RPEL motif, including the invariant arginine.	Arginine	118-126	phosphatase and actin regulator 1	Homo sapiens	82-86
19084810-3	2008	OBJECTIVE: The purpose of this study was to investigate the function and distribution of an ARVC-relevant PKP2 mutant where arginine at position 79 was replaced by a stop codon (R79x).	Arginine	124-132	plakophilin 2	Rattus norvegicus	106-110
18930675-2	2008	A homozygous missense HEXB mutation (p. D459A) was discovered in six patients with a rare juvenile variant: we show that this disrupts a salt bridge between aspartate D459 and arginine 505 at the subunit interface; R505 mutations are reported in late-onset Sandhoff disease.	Arginine	176-184	hexosaminidase subunit beta	Homo sapiens	22-26
18832001-1	2008	Agmatine, an endogenous amine derived from decarboxylation of L-arginine catalyzed by arginine decarboxylase, has been proposed as a neurotransmitter or neuromodulator in the brain.	Arginine	62-72	antizyme inhibitor 2	Rattus norvegicus	86-108
18784085-1	2008	To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i).	Arginine	147-150	coagulation factor X	Homo sapiens	28-37
18784085-1	2008	To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i).	Arginine	147-150	coagulation factor X	Homo sapiens	39-42
18784085-1	2008	To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i).	Arginine	147-150	coagulation factor X	Homo sapiens	70-73
18784085-1	2008	To test the hypothesis that factor Xa (fXa) interacts with protein S, fXa was labeled active-site specifically with a dansyl (D) dye via a Glu-Gly-Arg (EGR) tether to yield DEGR-fXa(i).	Arginine	147-150	coagulation factor X	Homo sapiens	70-73
18841999-3	2008	To explore the roles of the two post-translational modifications, we mutated the three C-terminal lysines to arginines in the human beta 2-adrenergic receptor (beta 2AR) (K348/372/375R).	Arginine	109-118	adrenoceptor beta 2	Homo sapiens	132-158
18841999-3	2008	To explore the roles of the two post-translational modifications, we mutated the three C-terminal lysines to arginines in the human beta 2-adrenergic receptor (beta 2AR) (K348/372/375R).	Arginine	109-118	adrenoceptor beta 2	Homo sapiens	160-168
18784072-10	2008	N-terminal sequencing identified the cleavage site at beta3 Arg(245), in a sequence context (SQLR(245) LQGSCFC) conserved among species and in remarkable agreement with reported consensus target sequences for hepsin activity.	Arginine	60-63	hepsin	Homo sapiens	209-215
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Arginine	287-299	pyrroline-5-carboxylate reductase 1	Homo sapiens	53-56
18637793-8	2008	In contrast, mutation of Arg(124) rendered AtPIP2;1 largely insensitive to Ca(2+) while remaining fully sensitive to H(+).	Arginine	25-28	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	43-51
18852303-10	2008	Replacement of arginine by alanine or glutamine (alpha,beta,gammaR138A/Q) completely abolished both the Na(+) current (I(Na)) and a 75-kD gamma-ENaC fragment at the cell surface stimulated by CAP2.	Arginine	15-23	sodium channel epithelial 1 subunit gamma	Homo sapiens	138-148
18852303-10	2008	Replacement of arginine by alanine or glutamine (alpha,beta,gammaR138A/Q) completely abolished both the Na(+) current (I(Na)) and a 75-kD gamma-ENaC fragment at the cell surface stimulated by CAP2.	Arginine	15-23	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	192-196
18799570-6	2008	A positively charged patch is apparent on the surface of sigmaA on the inside of this helix and mutation of either of two key arginine residues (Arg155 and Arg273) within this patch abolishes double-stranded RNA binding.	Arginine	126-134	sigma-A protein	Avian orthoreovirus	57-63
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	28-33
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	50-53
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	133-138
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	162-165
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	133-138
18827006-4	2008	Consistent with these data, SHP-2 is required for Abl-dependent PDGF-mediated proliferation since expression of an activated form of SHP-2 rescues the ability of Abl-Arg null fibroblasts to transit from G1 to S phase, whereas inhibition of SHP-2 signaling reduces the ability of Abl kinases to rescue the proliferation defect.	Arginine	166-169	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	162-165
18940611-0	2008	Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.	Arginine	94-102	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	50-55
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	88-93
18940611-4	2008	Based on these results, together with the results of in vitro binding assay with mutant ALG-2 and Alix proteins, we propose a Ca(2+)/EF3-driven arginine switch mechanism for ALG-2 binding to Alix.	Arginine	144-152	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	174-179
18645041-3	2008	In this report, we identified a novel naturally occurring posttranslational modification of chemokines, that is, the deimination of arginine at position 5 into citrulline of CXC chemokine ligand 10 (CXCL10) by rabbit PAD and human PAD2.	Arginine	132-140	peptidyl arginine deiminase 2	Homo sapiens	231-235
18612080-0	2008	Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4).	Arginine	19-27	ATP binding cassette subfamily C member 4	Homo sapiens	92-96
18612080-0	2008	Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4).	Arginine	19-27	ATP binding cassette subfamily C member 4	Homo sapiens	97-102
18614798-6	2008	Arginine-197 in PBR-N was a key residue to regulate subcellular localization of Nox5 and its interaction with PtdIns(4,5)P(2).	Arginine	0-8	translocator protein	Homo sapiens	16-19
18710948-10	2008	A ubiquitination-deficient mutant of IRF7 with these sites mutated to arginines completely loses transactivational ability in response not only to LMP1 but also to the IRF7 kinase IkappaB kinase epsilon.	Arginine	70-79	PDZ and LIM domain 7	Homo sapiens	147-151
18987609-7	2008	The highest frequency of total chromosomal aberrations was recorded in individuals with homozygous variant Gln/Gln cariers (2.14%) in XRCC1* Arg-399Gln and the lowest in those with the wild-type Arg/Arg cariers (1.33%).	Arginine	141-144	X-ray repair cross complementing 1	Homo sapiens	134-139
18987609-7	2008	The highest frequency of total chromosomal aberrations was recorded in individuals with homozygous variant Gln/Gln cariers (2.14%) in XRCC1* Arg-399Gln and the lowest in those with the wild-type Arg/Arg cariers (1.33%).	Arginine	195-198	X-ray repair cross complementing 1	Homo sapiens	134-139
18782275-7	2008	Despite the absence of FH in the plasma, this protein was detected in the patient"s fibroblasts, suggesting that Arg(127) may be important for FH secretion.	Arginine	113-116	complement factor H	Homo sapiens	143-145
18801197-7	2008	Substitutions of these four residues were engineered in mouse NAGS and into the vertebrate-like N-acetylglutamate synthase-kinase (NAGS-K) of Xanthomonas campestris, which is inhibited by arginine.	Arginine	188-196	N-acetylglutamate synthase	Homo sapiens	96-122
18801197-7	2008	Substitutions of these four residues were engineered in mouse NAGS and into the vertebrate-like N-acetylglutamate synthase-kinase (NAGS-K) of Xanthomonas campestris, which is inhibited by arginine.	Arginine	188-196	N-acetylglutamate synthase	Homo sapiens	131-135
18801197-9	2008	Fish NAGS were partially inhibited by arginine and frog NAGS were activated by arginine.	Arginine	38-46	N-acetylglutamate synthase	Homo sapiens	5-9
18801197-9	2008	Fish NAGS were partially inhibited by arginine and frog NAGS were activated by arginine.	Arginine	79-87	N-acetylglutamate synthase	Homo sapiens	5-9
18801197-9	2008	Fish NAGS were partially inhibited by arginine and frog NAGS were activated by arginine.	Arginine	79-87	N-acetylglutamate synthase	Homo sapiens	56-60
18801197-10	2008	CONCLUSION: Difference in arginine effect on bacterial and mammalian NAGS most likely stems from the difference in the type of conformational change triggered by arginine binding to these proteins.	Arginine	26-34	N-acetylglutamate synthase	Homo sapiens	69-73
18801197-10	2008	CONCLUSION: Difference in arginine effect on bacterial and mammalian NAGS most likely stems from the difference in the type of conformational change triggered by arginine binding to these proteins.	Arginine	162-170	N-acetylglutamate synthase	Homo sapiens	69-73
18801197-11	2008	The change from arginine inhibition of NAGS to activation was gradual, from complete inhibition of bacterial NAGS, to partial inhibition of fish NAGS, to activation of frog and mammalian NAGS.	Arginine	16-24	N-acetylglutamate synthase	Homo sapiens	39-43
18801197-11	2008	The change from arginine inhibition of NAGS to activation was gradual, from complete inhibition of bacterial NAGS, to partial inhibition of fish NAGS, to activation of frog and mammalian NAGS.	Arginine	16-24	N-acetylglutamate synthase	Homo sapiens	109-113
18801197-11	2008	The change from arginine inhibition of NAGS to activation was gradual, from complete inhibition of bacterial NAGS, to partial inhibition of fish NAGS, to activation of frog and mammalian NAGS.	Arginine	16-24	N-acetylglutamate synthase	Homo sapiens	109-113
18801197-11	2008	The change from arginine inhibition of NAGS to activation was gradual, from complete inhibition of bacterial NAGS, to partial inhibition of fish NAGS, to activation of frog and mammalian NAGS.	Arginine	16-24	N-acetylglutamate synthase	Homo sapiens	109-113
18651799-7	2008	We also develop a different, faster, ARG sampling method that still samples from a well-defined subspace of ARGs, and that is practical for larger sized datasets.	Arginine	37-40	serpin family A member 2 (gene/pseudogene)	Homo sapiens	108-112
20424661-2	2008	PURPOSE: To test for a possible association between two single-nucleotide polymorphisms (SNPs), XRCC1 399 G&gt;A Arg/Gln and XRCC3 241 C&gt;T Thr/Met and late reactions to radiotherapy.	Arginine	113-116	X-ray repair cross complementing 1	Homo sapiens	96-101
18481277-8	2008	Our data for the first time demonstrate that not only saposin C or PSAP regulates AR expression/activity, but also function as an ARG in PrSt.	Arginine	130-133	prosaposin	Homo sapiens	67-71
18028947-1	2008	BACKGROUND: l-arginine transport mediated by type-2 cationic amino acid transporter (CAT-2) isozymes is one crucial mechanism that regulates nitric oxide (NO) production via inducible nitric oxide synthase (iNOS).	Arginine	12-22	solute carrier family 7 member 2	Rattus norvegicus	85-90
18492485-1	2008	Insulin signaling in skeletal L6 myotubes is known to be affected by arginine methylation catalyzed by protein N-arginine methyltransferase 1 (PRMT1), however, the mechanism by which this occurs has not yet been defined.	Arginine	69-77	protein arginine methyltransferase 1	Homo sapiens	143-148
18657504-0	2008	Regulation of estrogen rapid signaling through arginine methylation by PRMT1.	Arginine	47-55	protein arginine methyltransferase 1	Homo sapiens	71-76
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	56-64	protein arginine methyltransferase 1	Homo sapiens	80-85
18657504-2	2008	Here we report a paradigm of ERalpha regulation through arginine methylation by PRMT1, which transiently methylates arginine 260 within the ERalpha DNA-binding domain.	Arginine	116-124	protein arginine methyltransferase 1	Homo sapiens	80-85
20641486-12	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
18468516-4	2008	Drosophila arginine methyltransferase 1 (DART1), the mammalian PRMT1 homologue, methylates the arginine residue of histone H4 (H4R3me2).	Arginine	11-19	protein arginine methyltransferase 1	Homo sapiens	63-68
18567752-7	2008	Dietary supplementation with 1.2% L-arginine increased (P &lt; 0.05) the concentration of jejunal endothelin-1 compared with the control pigs.	Arginine	34-44	endothelin-1	Sus scrofa	98-110
18243372-4	2008	Results showed that supplementation with L-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P&lt;0.001) and VEGF serum levels (P&lt;0.001).	Arginine	41-51	vascular endothelial growth factor A	Mus musculus	156-160
18243372-5	2008	Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.	Arginine	47-57	vascular endothelial growth factor A	Mus musculus	94-98
18540049-6	2008	An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1.	Arginine	3-11	fibroblast growth factor 1	Rattus norvegicus	64-67
18540049-6	2008	An arginine at position 116 is a consensus residue in mammalian FGF molecules; however, it is a serine in rat FGF1.	Arginine	3-11	fibroblast growth factor 1	Rattus norvegicus	110-114
18430791-4	2008	Because of her asthma history, self-reported adherence, and race, she was tested for beta(2)-adrenoreceptor genotype, which revealed Arg/Arg.	Arginine	133-136	adrenoceptor beta 2	Homo sapiens	85-107
18430791-4	2008	Because of her asthma history, self-reported adherence, and race, she was tested for beta(2)-adrenoreceptor genotype, which revealed Arg/Arg.	Arginine	137-140	adrenoceptor beta 2	Homo sapiens	85-107
18004563-9	2008	An arginine(R)-to-cysteine(C) exchange at position 442 generated an immunogenic T cell epitope equivalent to a minor histocompatibility antigen (mHag).	Arginine	3-11	myosin IG	Homo sapiens	111-150
18004563-9	2008	An arginine(R)-to-cysteine(C) exchange at position 442 generated an immunogenic T cell epitope equivalent to a minor histocompatibility antigen (mHag).	Arginine	12-13	myosin IG	Homo sapiens	111-150
18326694-1	2008	PURPOSE: To elucidate the basis of the autosomal dominant congenital nuclear cataracts caused by the connexin50 mutant, CX50R23T, by determining its cellular distribution and functional behavior and the consequences of substituting other amino acids for arginine-23.	Arginine	254-262	gap junction protein alpha 8	Homo sapiens	101-111
18215125-10	2008	The protease domain of neurobin, produced in Escherichia coli and refolded from inclusion bodies, cleaved chromogenic peptides with an arginine residue in position P(1).	Arginine	135-143	transmembrane protease, serine 11c	Mus musculus	23-31
18215125-13	2008	Recombinant neurobin processed 17-kDa FGF-2 (fibroblast growth factor-2) at several P(1) lysine and arginine positions to distinct fragments, in a heparin-inhibitable manner, but did not cleave FGF-7, laminin or fibronectin.	Arginine	100-108	transmembrane protease, serine 11c	Mus musculus	12-20
17997414-9	2008	RESULTS: A combination of arginine and aminoguanidine recovered the plasma level of arginine at 6 h post-CLP, decreased expression of HO-1 in liver and lung at 24 h post-CLP, decreased urinary excretion of epinephrine, norepinephrine, dopamine, and 17-hydroxycorticosteroid in the first 24 h post-CLP, and increased 7-d survival.	Arginine	26-34	heme oxygenase 1	Rattus norvegicus	134-138
18285453-5	2008	We demonstrate that PRMT1 interacts with MRE11 but not with the MRN complex, suggesting that MRE11 arginine methylation occurs prior to the binding of NBS1 and RAD50.	Arginine	99-107	protein arginine methyltransferase 1	Homo sapiens	20-25
18285453-7	2008	The inhibition of arginine methylation leads to a reduction in MRE11 and RAD51 focus formation on a unique double-strand break in vivo.	Arginine	18-26	RAD51 recombinase	Homo sapiens	73-78
18252709-6	2008	Furthermore, substitution of tryptophan 469 of GlyT2 by an arginine generated a transporter deficient in dimerization that was retained intracellulary.	Arginine	59-67	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	47-52
18230622-7	2008	Its inhibitory action was dependent on the association of TRPC4alpha with actin cytoskeleton as it was prevented by cytochalasin D treatment or by the deletion of the C-terminal PDZ-binding motif (Thr-Thr-Arg-Leu) that links TRPC4 to F-actin through the sodium-hydrogen exchanger regulatory factor and ezrin.	Arginine	205-208	transient receptor potential cation channel subfamily C member 4	Homo sapiens	58-63
18228201-11	2008	The increased eNOS expression accompanied by an increased nitrotyrosine immunoreaction observed in both L-arginine-treated groups compared to corresponding controls strengthens this hypothesis.	Arginine	104-114	nitric oxide synthase 3	Rattus norvegicus	14-18
18212250-3	2008	A hKOR mutant (hKOR-10 KR) in which all 10 intracellular Lys residues were changed to Arg showed greatly reduced basal and agonist-promoted receptor ubiquitination and substantially decreased Dyn A-induced receptor down-regulation, without changing ligand binding affinity, receptor-G protein coupling, or receptor internalization or desensitization.	Arginine	86-89	opioid receptor kappa 1	Homo sapiens	2-6
18212250-3	2008	A hKOR mutant (hKOR-10 KR) in which all 10 intracellular Lys residues were changed to Arg showed greatly reduced basal and agonist-promoted receptor ubiquitination and substantially decreased Dyn A-induced receptor down-regulation, without changing ligand binding affinity, receptor-G protein coupling, or receptor internalization or desensitization.	Arginine	86-89	opioid receptor kappa 1	Homo sapiens	15-19
18208508-7	2008	Replacement of the eight cytoplasmic lysines by arginines results in a marked accumulation of CD1e in trans Golgi network 46+ compartments, its expression on the plasma membrane and a moderate slowing of its transport to Ls.	Arginine	48-57	CD1e molecule	Homo sapiens	94-98
18307317-5	2008	The coassembly of rotor (Vma3p TM4) and stator (Vph1p TM7) peptides, which respectively contain the glutamate and arginine residues essential to proton transport by the rotary ATPase mechanism, is demonstrated from changes in the lipid interaction stoichiometry and helix orientation.	Arginine	114-122	H(+)-transporting V0 sector ATPase subunit c	Saccharomyces cerevisiae S288C	25-30
18307317-5	2008	The coassembly of rotor (Vma3p TM4) and stator (Vph1p TM7) peptides, which respectively contain the glutamate and arginine residues essential to proton transport by the rotary ATPase mechanism, is demonstrated from changes in the lipid interaction stoichiometry and helix orientation.	Arginine	114-122	H(+)-transporting V0 sector ATPase subunit a	Saccharomyces cerevisiae S288C	48-53
20641534-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Mus musculus	136-147
17651798-6	2008	The FPRL1 antagonist, Trp-Arg-Trp-Trp-Trp (WRW4), decreased PACAP-evoked Ca2+ signal, Akt, ERK phosphorylation, ROS and CD11b upregulation without affecting p38 phosphorylation.	Arginine	26-29	integrin subunit alpha M	Homo sapiens	120-125
18364017-1	2008	Agmatine is an endogenous amine derived from decarboxylation of arginine catalysed by arginine decarboxylase.	Arginine	64-72	antizyme inhibitor 2	Rattus norvegicus	86-108
18310453-9	2008	Intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in IA-2/IA-2beta KO than control islets.	Arginine	54-62	protein tyrosine phosphatase, receptor type, N polypeptide 2	Mus musculus	127-135
18223652-6	2008	MALT1 cleaved human A20 after arginine 439 and impaired its NF-kappaB-inhibitory function.	Arginine	30-38	immunoglobulin kappa variable 1-27	Homo sapiens	20-23
18327399-1	2008	Incorporation of factor (F) Va into prothrombinase directs prothrombin activation by FXa through the meizothrombin pathway, characterized by initial cleavage at Arg(320).	Arginine	161-164	coagulation factor X	Homo sapiens	85-88
17700528-2	2008	We recently demonstrated that endogenous Abl kinases (c-Abl, Arg) are activated by deregulated ErbB receptors and Src kinases, and drive invasion of aggressive breast cancer cells.	Arginine	61-64	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	41-44
17700528-2	2008	We recently demonstrated that endogenous Abl kinases (c-Abl, Arg) are activated by deregulated ErbB receptors and Src kinases, and drive invasion of aggressive breast cancer cells.	Arginine	61-64	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	54-59
18057120-6	2008	L-arginine (L-arg; 500 micromol/l) increased DAF-2 DA fluorescence by 51% compared with control (n = 8; P &lt; 0.05).	Arginine	0-10	insulin receptor	Oryctolagus cuniculus	45-50
18057120-6	2008	L-arginine (L-arg; 500 micromol/l) increased DAF-2 DA fluorescence by 51% compared with control (n = 8; P &lt; 0.05).	Arginine	0-5	insulin receptor	Oryctolagus cuniculus	45-50
18361930-1	2008	Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant rejection, and diabetes.	Arginine	138-146	intercellular adhesion molecule 1	Homo sapiens	63-103
17624554-2	2008	Single nucleotide polymorphism (SNP) of arginine (Arg, CGA) or glutamine (Gln, CAA) at codon 302 is known on RAD18; however, the association between the SNP and the risk of any human cancers including non-small-cell lung cancer (NSCLC) has not been reported.	Arginine	40-48	RAD18 E3 ubiquitin protein ligase	Homo sapiens	109-114
17624554-2	2008	Single nucleotide polymorphism (SNP) of arginine (Arg, CGA) or glutamine (Gln, CAA) at codon 302 is known on RAD18; however, the association between the SNP and the risk of any human cancers including non-small-cell lung cancer (NSCLC) has not been reported.	Arginine	50-53	RAD18 E3 ubiquitin protein ligase	Homo sapiens	109-114
17961713-3	2008	An exon 10 variant at codon 399 of XRCC1 leads to an Arg to Gln amino acid change.	Arginine	53-56	X-ray repair cross complementing 1	Homo sapiens	35-40
18574322-6	2008	The ratio of differentiation of CAT1-knockdown K562 cells was well correlated with the uptake activity for arginine by the cells (R(2)=0.59).	Arginine	107-115	solute carrier family 7 member 1	Homo sapiens	32-36
18574322-7	2008	These findings indicate that CAT1 is directly involved in erythropoiesis through supplying arginine to the blood cells.	Arginine	91-99	solute carrier family 7 member 1	Homo sapiens	29-33
18173750-6	2008	Mutational analyses of the HsRad51-Lys313 residue revealed that positively charged residues (Lys and Arg), but not negatively charged, polar and hydrophobic residues (Glu, Gln and Met, respectively), at position 313 reduced the strand-exchange and DNA unwinding abilities of the HsRad51 protein.	Arginine	101-104	RAD51 recombinase	Homo sapiens	27-34
19088492-7	2008	In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f.	Arginine	26-29	adrenoceptor beta 2	Homo sapiens	20-25
19088492-7	2008	In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f.	Arginine	30-33	adrenoceptor beta 2	Homo sapiens	20-25
18079449-6	2008	On the other hand, the percentage of CD8+ cells was highest in birds fed the HARG-VE80 feed compared with all the other Arg and VE combinations.	Arginine	120-123	CD8a molecule	Gallus gallus	37-40
18000034-4	2008	Within the QUA2 domain, a transposition of adjacent arginine and lysine residues is primarily responsible for the switch in RNA binding between BBP and SF1.	Arginine	52-60	splicing factor 1	Homo sapiens	152-155
18442016-0	2007	Polymorphism of XRCC1 codon arg 399 Gln is associated with higher susceptibility to endometriosis.	Arginine	28-31	X-ray repair cross complementing 1	Homo sapiens	16-21
18156033-1	2007	BACKGROUND: New evidence has suggested that people with asthma who are homozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from longacting beta2-agonist therapy.	Arginine	86-94	adrenoceptor beta 2	Homo sapiens	118-143
18156033-1	2007	BACKGROUND: New evidence has suggested that people with asthma who are homozygous for arginine at aminoacid 16 of the beta2-adrenergic receptor (ADRB2) might not benefit from longacting beta2-agonist therapy.	Arginine	86-94	adrenoceptor beta 2	Homo sapiens	145-150
20641798-19	2004	(1) showed that the kidney uptake of a rhenium cyclized DOTA-alpha-MSH analog [DOTA-Re(Arg(11))CCMSH] could be considerably reduced and tumor uptake could be enhanced significantly by substitution the Lys(11) residue with Arg(11) in order to delocalize the charge of the Lys(11) residue.	Arginine	87-90	msh homeobox 1	Mus musculus	67-70
20641798-19	2004	(1) showed that the kidney uptake of a rhenium cyclized DOTA-alpha-MSH analog [DOTA-Re(Arg(11))CCMSH] could be considerably reduced and tumor uptake could be enhanced significantly by substitution the Lys(11) residue with Arg(11) in order to delocalize the charge of the Lys(11) residue.	Arginine	222-225	msh homeobox 1	Mus musculus	67-70
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	87-91
18082610-5	2007	We found that translation elongation factor 3 (YEF3) and the ribonucleotide reductase (RNR1 and RNR3) large subunits are overrepresented with specific arginine and glutamic acid codons, and we demonstrated that Trm9 significantly enhances Yef3, Rnr1, and Rnr3 protein levels.	Arginine	151-159	ribonucleotide-diphosphate reductase subunit RNR1	Saccharomyces cerevisiae S288C	245-249
17906292-5	2007	Of all the various acidic, basic, and aromatic residues studied, mutation of positionally conserved arginines in the class I or class II repeat modules significantly attenuated Pur beta repressor activity in transfected vascular smooth muscle cells and fibroblasts.	Arginine	100-109	purine rich element binding protein B	Mus musculus	177-185
17906292-9	2007	These findings point to a previously unrecognized structural role for certain core arginine residues in forming a conformationally stable Pur beta protein capable of physical interactions necessary for smooth muscle alpha-actin gene repression.	Arginine	83-91	purine rich element binding protein B	Mus musculus	138-146
17913711-3	2007	To understand the molecular structural basis of enzyme regulation by PII, we have determined a 2.5-A resolution crystal structure of a complex formed between two homotrimers of PII and a single hexamer of NAGK from Arabidopsis thaliana bound to the metabolites N-acetylglutamate, ADP, ATP, and arginine.	Arginine	294-302	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	205-209
17913711-6	2007	Interactions between PII and NAGK appear to limit the degree of opening and closing of the active-site cleft in opposition to a domain-separating inhibitory effect exerted by arginine, thus explaining the stimulatory effect of PII on the kinetics of arginine-inhibited NAGK.	Arginine	175-183	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	29-33
17913711-6	2007	Interactions between PII and NAGK appear to limit the degree of opening and closing of the active-site cleft in opposition to a domain-separating inhibitory effect exerted by arginine, thus explaining the stimulatory effect of PII on the kinetics of arginine-inhibited NAGK.	Arginine	250-258	N-acetyl-l-glutamate kinase	Arabidopsis thaliana	29-33
17924945-2	2007	Here we show that site-specific mutation of one conserved arginine to glutamine within the RNA recognition motif impairs binding of recombinant AtGRP7 to its pre-mRNA in vitro.	Arginine	58-66	cold, circadian rhythm, and rna binding 2	Arabidopsis thaliana	144-150
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Arginine	60-68	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	54-59
18042456-5	2007	The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition.	Arginine	60-68	cyclin-dependent serine/threonine-protein kinase PHO85	Saccharomyces cerevisiae S288C	125-130
18006764-7	2007	Of these three XRCC1 polymorphisms, the codon 399 Arg/Gln + Gln/Gn genotypes were significantly associated with higher risk of PSA recurrence after radical prostatectomy compared with the Arg/Arg genotype (34.0% versus 15.1%, P = 0.013) and poorer PSA-free survival (log-rank test, P = 0.0056).	Arginine	188-191	X-ray repair cross complementing 1	Homo sapiens	15-20
18006764-7	2007	Of these three XRCC1 polymorphisms, the codon 399 Arg/Gln + Gln/Gn genotypes were significantly associated with higher risk of PSA recurrence after radical prostatectomy compared with the Arg/Arg genotype (34.0% versus 15.1%, P = 0.013) and poorer PSA-free survival (log-rank test, P = 0.0056).	Arginine	188-191	X-ray repair cross complementing 1	Homo sapiens	15-20
18006764-8	2007	After considering for other covariates in a Cox proportional hazard model, the XRCC1 Arg/Gln and Gln/Gln genotypes (hazard ratio, 4.73; 95% confidence interval, 1.61-13.92; P = 0.005) and high Gleason score (Gleason score, 8-10; hazard ratio, 5.58; 95% confidence interval, 1.58-19.71; P = 0.008) were still independent predictors of poor PSA-free survival after radical prostatectomy.	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	79-84
17848548-1	2007	The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin.	Arginine	96-99	coagulation factor X	Homo sapiens	52-66
17848548-1	2007	The preferred pathway for prothrombin activation by prothrombinase involves initial cleavage at Arg(320) to produce meizothrombin, which is then cleaved at Arg(271) to liberate thrombin.	Arginine	156-159	coagulation factor X	Homo sapiens	52-66
17848548-8	2007	We further show that prior cleavage at the 320 site or the stabilization of the uncleaved zymogen in a proteinase-like state facilitates efficient docking of Arg(271) at the active site of prothrombinase.	Arginine	158-161	coagulation factor X	Homo sapiens	189-203
17717015-11	2007	Furthermore, L-arginine enhanced both nuclear factor-kB (NF-kB) and neuronal nitric oxide synthase (nNOS) immunopositivities.	Arginine	13-23	nitric oxide synthase 1	Rattus norvegicus	68-98
17717015-11	2007	Furthermore, L-arginine enhanced both nuclear factor-kB (NF-kB) and neuronal nitric oxide synthase (nNOS) immunopositivities.	Arginine	13-23	nitric oxide synthase 1	Rattus norvegicus	100-104
17761772-4	2007	We have therefore investigated the effects of restricted placental growth and function on plasma glucose, alpha-amino nitrogen and insulin concentrations and glucose- and arginine-stimulated insulin secretion in the fetal sheep at 120 and 140 days gestational age, and on insulin sensitivity, measured by hyperinsulinaemic euglycaemic clamp, at 130 days gestational age.	Arginine	171-179	LOC105613195	Ovis aries	191-198
17761772-6	2007	Reduced fetal and placental weights and indices of poor placental function, in particular fetal hypoxia and hypoglycaemia, were associated with impaired glucose- and arginine-stimulated insulin secretion, but not with changes in insulin sensitivity in the fetal sheep.	Arginine	166-174	LOC105613195	Ovis aries	186-193
17914568-2	2007	In the human RAD18 gene, one coding single nucleotide polymorphism (SNP) at codon 302, encoding either arginine (Arg, CGA) or glutamine (Gln, CAA), was reported.	Arginine	103-111	RAD18 E3 ubiquitin protein ligase	Homo sapiens	13-18
17914568-2	2007	In the human RAD18 gene, one coding single nucleotide polymorphism (SNP) at codon 302, encoding either arginine (Arg, CGA) or glutamine (Gln, CAA), was reported.	Arginine	113-116	RAD18 E3 ubiquitin protein ligase	Homo sapiens	13-18
17882261-3	2007	The crystal structures of the CARM1 catalytic core in the apo and holo states reveal cofactor-dependent formation of a substrate-binding groove providing a specific access channel for arginine to the active site.	Arginine	184-192	coactivator associated arginine methyltransferase 1	Homo sapiens	30-35
17892306-3	2007	This technique required the engineering of Abl/Arg to utilize an unnatural ATP analogue as a phospho-donor.	Arginine	47-50	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	43-46
17892306-4	2007	Mutation of T334A and T361A in Abl and Arg, respectively, altered their nucleotide specificity and allowed them to utilize N6-benzyl-ATP as a phospho-donor.	Arginine	39-42	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	31-34
17726370-2	2007	Therefore, the aims of the present study were to refine the feedback regulation of protein arginine methylation using one of the heavily methylated proteins, an RNA-binding protein Sam68, as a prototype, to elucidate the relations between Sam68 methylation and tyrosine phosphorylation and the role of methylation in RNA binding and subcellular distribution, as well as the cellular consequences of reduced protein methylation.	Arginine	91-99	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	181-186
17726370-4	2007	Advanced glycation-modified collagen I, which accumulates in diabetes and induces formation of peroxynitrite and premature endothelial cell senescence, also inhibited arginine methylation of Sam68.	Arginine	167-175	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	191-196
17726370-5	2007	When the level of arginine methylation of Sam68 was pharmacologically reduced, this did not affect its RNA binding or degree of tyrosine phosphorylation, but resulted in the predominantly nuclear hypomethylation pattern.	Arginine	18-26	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	42-47
17634203-10	2007	An in vivo experiment revealed that H(2)S downregulated the vascular l-Arg/eNOS/NO pathway after intraperitoneal injection of NaHS (14 micromol/kg) in rats.	Arginine	69-74	nitric oxide synthase 3	Rattus norvegicus	75-79
17178122-13	2007	In conclusion, aortic arginine uptake is attenuated in hypercholesterolemia, through post-translational modulation of CAT-1 protein, possibly via upregulation of PKC alpha.	Arginine	22-30	protein kinase C, alpha	Rattus norvegicus	162-171
17686996-5	2007	Expression of Abl but not AbkKD in Abl/Arg-deficient cells again inhibits spreading.	Arginine	39-42	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	14-17
17719140-0	2007	Apelin activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas.	Arginine	17-27	apelin	Rattus norvegicus	0-6
17719140-2	2007	To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) pathway in the incubated, isolated rat aorta.	Arginine	110-120	apelin	Rattus norvegicus	96-102
17719140-2	2007	To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) pathway in the incubated, isolated rat aorta.	Arginine	122-127	apelin	Rattus norvegicus	96-102
17719140-6	2007	Apelin incubation (10(-9), 10(-8), and 10(-7)mol/L) increased L-Arg uptake by 130%, 180%, and 240% (all p&lt;0.01), respectively.	Arginine	62-67	apelin	Rattus norvegicus	0-6
17719140-9	2007	Collectively, these results demonstrate that apelin directly activated the vascular L-Arg/NOS/NO pathway, which could be one of the important mechanisms of apelin-regulated vascular function.	Arginine	84-89	apelin	Rattus norvegicus	45-51
17719140-9	2007	Collectively, these results demonstrate that apelin directly activated the vascular L-Arg/NOS/NO pathway, which could be one of the important mechanisms of apelin-regulated vascular function.	Arginine	84-89	apelin	Rattus norvegicus	156-162
17711414-7	2007	The analysis of a T-DNA mutant line lacking AtPRMT11 mRNA revealed reduced levels of proteins with asymmetrically dimethylated arginines, suggesting that AtPRMT11, which is highly similar to mammalian PRMT1, is indeed a type I arginine methyltransferase.	Arginine	127-136	protein arginine methyltransferase 1	Homo sapiens	46-51
17555508-8	2007	RESULTS: Sequence analysis revealed a novel de novo heterozygous mutation at codon 551 (AGG--&gt;AAG), predicting a change of arginine to lysine (R551K) and a known heterozygous polymorphism (A986S) on the same allele, which was inherited from the father.	Arginine	126-134	N-methylpurine DNA glycosylase	Homo sapiens	97-100
17666372-9	2007	In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	17-22
17666372-9	2007	In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	17-22
17666372-9	2007	In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	17-22
17666372-9	2007	In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	17-22
17666372-9	2007	In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.	Arginine	86-89	X-ray repair cross complementing 1	Homo sapiens	17-22
17625935-2	2007	The l-arginine metabolite asymmetric dimethylarginine (ADMA) is a potent, noncompetitive inhibitor of nNOS, while its congener N(G)-monomethyl-l-arginine (l-NMMA) is a less potent, competitive inhibitor.	Arginine	4-14	nitric oxide synthase 1	Rattus norvegicus	102-106
20641803-5	2004	A tripeptide sequence consisting of Arg-Gly-Asp (RGD) has been identified as a recognition motif used by extracellular matrix proteins (vitronectin, fibrinogen, laminin, and collagen) to bind to a variety of integrins, including alphavbeta3.	Arginine	36-39	vitronectin	Homo sapiens	136-147
17442735-0	2007	MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.	Arginine	15-23	dual specificity phosphatase 1	Mus musculus	0-5
17442735-4	2007	We hypothesized that MKP-1, by attenuating iNOS expression, acts as a switch changing L-arg metabolism from NO production to L-orn production after endotoxin administration.	Arginine	86-91	dual specificity phosphatase 1	Mus musculus	21-26
17666851-0	2007	Identification of arginine analogues as antagonists and agonists for the melanocortin-4 receptor.	Arginine	18-26	melanocortin 4 receptor	Homo sapiens	73-96
17544230-6	2007	Under the same experimental condition, lysine to arginine substitution of histone H3 at position 36 abolished the methyltransferase activity of Drosophila ASH1, suggesting that K36 is their specific target.	Arginine	49-57	keratin 36	Homo sapiens	177-180
17877151-5	2007	Cell adhesion was partially inhibited by Arg-Gly-Asp (RGD) peptide, anti-beta1 integrin suggesting that integrin beta1 receptors have roles to play in the process.	Arginine	41-44	integrin subunit beta 1	Homo sapiens	104-118
17608478-1	2007	The molybdenum site of the Arginine 160 --&gt; Glutamine clinical mutant of the physiologically vital enzyme sulfite oxidase has been investigated by a combination of X-ray absorption spectroscopy and density functional theory calculations.	Arginine	27-35	sulfite oxidase	Homo sapiens	109-124
17573539-5	2007	Western blot using symmetric dimethyl histone H4 Arg 3-specific antibody and thin-layer chromatography analysis demonstrated that AtPRMT5 is a type II enzyme.	Arginine	49-52	SHK1 binding protein 1	Arabidopsis thaliana	130-137
17550233-5	2007	PRMT1 and PRMT3 showed a preference for methylating arginine residues in the first AT-hook of HMGA1 proteins, whereas PRMT6 methylated mainly residues in the second AT-hook.	Arginine	52-60	protein arginine methyltransferase 1	Homo sapiens	0-5
17489985-5	2007	Further, compared with subjects having both ADH2 His/His and ALDH2 Glu/Glu, the adjusted OR and its 95% CI for those with both ADH2 Arg/Arg and ALDH2 Glu/Lys was 5.00 (2.32-10.71) in all subjects.	Arginine	136-139	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	127-131
17489985-9	2007	In conclusion, this case-control study showed a significantly increased risk of SCCHN in subjects with the ADH2 Arg/Arg and ALDH2 Glu/Lys polymorphisms in a Japanese population.	Arginine	112-115	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	107-111
17489985-9	2007	In conclusion, this case-control study showed a significantly increased risk of SCCHN in subjects with the ADH2 Arg/Arg and ALDH2 Glu/Lys polymorphisms in a Japanese population.	Arginine	116-119	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	107-111
17475770-4	2007	We show that the previously reported decreased levels of L-arginine in btn1-Delta limit the synthesis of nitric oxide (.NO) in both physiological and oxidative stress conditions.	Arginine	57-67	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	71-75
17317851-3	2007	The Met-alpha(2)AP gene codes for either Arg or Trp as the sixth amino acid, with both polymorphic forms found in human plasma samples.	Arginine	41-44	serpin family F member 2	Homo sapiens	8-18
17489562-1	2007	The human ecto-ATPase (NTPDase 2) contains conserved motifs including five apyrase conserved regions (ACRs) and four conserved regions (CRs) as well as conserved lysine and arginine residues that are also present in other cell surface E-NTPDases.	Arginine	173-181	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	23-32
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	134-137	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	134-137	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	173-176	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	173-176	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	173-176	aldo-keto reductase family 1 member A1	Homo sapiens	23-44
17515815-11	2007	In the polymorphism of alcohol dehydrogenase (ADH2), prevalence of osteophyte formation without disc height narrowing was less in His/Arg (odds ratio = 0.57, P = 0.041) and Arg/Arg (odds ratio = 0.41, P = 0.18) than His/His.	Arginine	173-176	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	46-50
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Arginine	215-218	vitronectin	Homo sapiens	63-74
17355965-5	2007	Interestingly, the five residues identified as "hot spots" for vitronectin binding form a contiguous epitope consisting of two exposed loops connecting the central fourstranded beta-sheet in uPAR domain I (Trp(32), Arg(58), and Ile(63)) as well as a proximal region of the flexible linker peptide connecting uPAR domains I and II (Arg(91) and Tyr(92)).	Arginine	331-334	vitronectin	Homo sapiens	63-74
17303641-10	2007	These features suggest that the activity of the low-affinity, high-capacity CAT-2A member of the y(2+) family of transporters is responsible for L-Arg currents in acutely isolated cardiomyocytes.	Arginine	145-150	solute carrier family 7 member 2	Rattus norvegicus	76-82
17376561-1	2007	Alpha-melanotropin, Ac-Ser(1)-Tyr-Ser-Met-Glu-His(6)-Phe(7)-Arg(8)-Trp(9)-Gly-Lys-Pro-Val(13)-NH(2)(1), is a non-selective endogenous agonist for the melanocortin receptor 5; the receptor present in various peripheral tissues and in the brain, cortex and cerebellum.	Arginine	60-63	melanocortin 5 receptor	Homo sapiens	150-173
17438221-4	2007	Although the patient met criteria for multiple sclerosis (MS), the proteolipid protein-1 gene (PLP1) contained a mutation in exon 3B (c.409C>T), predicting a tryptophan-for-arginine substitution.	Arginine	173-181	proteolipid protein 1	Homo sapiens	67-88
17438221-4	2007	Although the patient met criteria for multiple sclerosis (MS), the proteolipid protein-1 gene (PLP1) contained a mutation in exon 3B (c.409C>T), predicting a tryptophan-for-arginine substitution.	Arginine	173-181	proteolipid protein 1	Homo sapiens	95-99
17320110-6	2007	A 50 amino acid residue transferable arginine-rich nucleolar localization signal (NoLS) identified in RASSF5 is capable of interacting with importin-beta and transporting the cargo into the nucleolus.	Arginine	37-45	Ras association domain family member 5	Homo sapiens	102-108
17425781-3	2007	Unlike the other urea cycle enzymes, whose bacterial counterparts could be readily identified by their sequence conservation with arginine biosynthetic enzymes, mammalian NAGS gene was very divergent, making it the last urea cycle gene to be discovered.	Arginine	130-138	N-acetylglutamate synthase	Homo sapiens	171-175
17425781-9	2007	Mammalian NAGS and its bacterial homolog have similar affinities for substrates acetyl coenzyme A and glutamate as well as for their allosteric regulator arginine.	Arginine	154-162	N-acetylglutamate synthase	Homo sapiens	10-14
17170029-8	2007	We found that injection of L-arginine was followed by significant increases in plasma amylase and pancreatic myeloperoxidase accompanied by marked histopathological changes.	Arginine	27-37	myeloperoxidase	Mus musculus	109-124
17391064-7	2007	Through screening of a panel of fluorogenic and chromogenic peptide substrates, we establish that active KLK12 possesses trypsin-like activity, cleaving peptide bonds after both arginine and lysine.	Arginine	178-186	kallikrein related peptidase 12	Homo sapiens	105-110
17237498-4	2007	Analysis of arginines in extracellular loop 2 revealed that mutating arginine 156 but not arginine 171 or 178 to alanine resulted in complete loss of LTB(4) binding to BLT1.	Arginine	69-77	leukotriene B4 receptor	Homo sapiens	168-172
17306540-5	2007	Even though cortactin can be tyrosine phosphorylated by Src-family kinases in vitro [8], we show that Abl and Arg are more adept at binding and phosphorylating cortactin.	Arginine	110-113	cortactin	Homo sapiens	12-21
17306540-5	2007	Even though cortactin can be tyrosine phosphorylated by Src-family kinases in vitro [8], we show that Abl and Arg are more adept at binding and phosphorylating cortactin.	Arginine	110-113	cortactin	Homo sapiens	160-169
17306540-6	2007	Importantly, we demonstrate that platelet-derived growth-factor (PDGF)-induced cortactin phosphorylation on three tyrosine residues requires Abl or Arg.	Arginine	148-151	cortactin	Homo sapiens	79-88
17306540-8	2007	We provide evidence that Abl/Arg-mediated phosphorylation of cortactin is required for this PDGF-induced dorsal-wave response.	Arginine	29-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	25-28
17306540-8	2007	We provide evidence that Abl/Arg-mediated phosphorylation of cortactin is required for this PDGF-induced dorsal-wave response.	Arginine	29-32	cortactin	Homo sapiens	61-70
20483281-0	2007	Structure and function of sheep hemoglobin Chios: A novel allele at the HBBB locus with two Lys--&gt;Arg substitutions at positions beta66(E10) and beta144(HC1).	Arginine	101-104	hemoglobin subunit beta	Ovis aries	72-76
20483281-4	2007	Sequencing of the beta-globin gene confirmed the variant gene as being an allele of the HBBB locus having the AAG--&gt;AGG and the AAA--&gt;AGA mutations at codons 66 and 144, respectively, both corresponding to the Lys--&gt;Arg substitution.	Arginine	225-228	hemoglobin subunit beta	Ovis aries	88-92
17417947-9	2007	When assessed in nonsmokers, only the Arg/Trp genotype of XRCC1 codon 194 was positively associated with lung cancer (OR--2.3, 95% CI--0.77-7.20).	Arginine	38-41	X-ray repair cross complementing 1	Homo sapiens	58-63
17417947-10	2007	Smoking also seemed to significantly interact with the combined genotypes of XRCC1 codon 399 Arg/Gln/Gln/Gln.	Arginine	93-96	X-ray repair cross complementing 1	Homo sapiens	77-82
17336757-0	2007	Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure.	Arginine	0-8	adrenoceptor beta 2	Homo sapiens	20-38
17336757-2	2007	In healthy human beings, those who are homozygous for arginine (Arg) at amino acid 16 of the ADRB2 have reduced receptor function when compared with individuals homozygous for glycine (Gly) at this position.	Arginine	54-62	adrenoceptor beta 2	Homo sapiens	93-98
17336757-2	2007	In healthy human beings, those who are homozygous for arginine (Arg) at amino acid 16 of the ADRB2 have reduced receptor function when compared with individuals homozygous for glycine (Gly) at this position.	Arginine	64-67	adrenoceptor beta 2	Homo sapiens	93-98
17166902-0	2007	RNA binding by the herpes simplex virus type 1 nucleocytoplasmic shuttling protein UL47 is mediated by an N-terminal arginine-rich domain that also functions as its nuclear localization signal.	Arginine	117-125	tegument protein VP13/14	Human alphaherpesvirus 1	83-87
17555083-6	2007	The frequencies of occurrence of the Arg and Trp alleles of XRCC1 194 were 85% and 15%.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	60-65
17555083-7	2007	The frequencies of occurrence of the Arg and His alleles of XRCC1 280 were 85% and 15%, too.	Arginine	37-40	X-ray repair cross complementing 1	Homo sapiens	60-65
17555083-9	2007	The risk of chromosomal damage induced by VCM for individuals carrying XRCC1 c. 194 Arg/Arg genotype was 0.6898 (95% CI 0.4997 - 0.9333, P = 0.0195) of those carrying Arg/Trp, Trp/Trp genotypes.	Arginine	84-87	X-ray repair cross complementing 1	Homo sapiens	71-76
17555083-9	2007	The risk of chromosomal damage induced by VCM for individuals carrying XRCC1 c. 194 Arg/Arg genotype was 0.6898 (95% CI 0.4997 - 0.9333, P = 0.0195) of those carrying Arg/Trp, Trp/Trp genotypes.	Arginine	88-91	X-ray repair cross complementing 1	Homo sapiens	71-76
17555083-9	2007	The risk of chromosomal damage induced by VCM for individuals carrying XRCC1 c. 194 Arg/Arg genotype was 0.6898 (95% CI 0.4997 - 0.9333, P = 0.0195) of those carrying Arg/Trp, Trp/Trp genotypes.	Arginine	88-91	X-ray repair cross complementing 1	Homo sapiens	71-76
17555083-13	2007	CONCLUSION: It was suggested that female workers and subjects carrying XRCC1 194 Arg/Arg genotypes could be higher risk of chromosomal damage when they exposed to VCM.	Arginine	81-84	X-ray repair cross complementing 1	Homo sapiens	71-76
17555083-13	2007	CONCLUSION: It was suggested that female workers and subjects carrying XRCC1 194 Arg/Arg genotypes could be higher risk of chromosomal damage when they exposed to VCM.	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	71-76
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Arginine	24-27	carboxypeptidase N subunit 1	Homo sapiens	129-133
17157876-6	2007	Modeling of the Pro-Phe-Arg C-terminal end of the natural substrate bradykinin into the active site shows that the S1" pocket of CPN1 might better accommodate P1"-Lys than Arg residues, in agreement with CPN"s preference for cleaving off C-terminal Lys residues.	Arginine	24-27	carboxypeptidase N subunit 1	Homo sapiens	129-132
17256796-1	2007	In classical achondroplasia (Ach), a glycine residue is replaced by an arginine at codon 380 in exon 10 of the fibroblast growth factor receptor 3 gene (FGFR3).	Arginine	71-79	fibroblast growth factor receptor 3	Homo sapiens	111-146
17256796-1	2007	In classical achondroplasia (Ach), a glycine residue is replaced by an arginine at codon 380 in exon 10 of the fibroblast growth factor receptor 3 gene (FGFR3).	Arginine	71-79	fibroblast growth factor receptor 3	Homo sapiens	153-158
17065601-4	2007	Our data suggest that l-arginine is taken up by Sertoli cells and peritubular cells, principally via system y(+)L (SLC3A2/SLC7A6) and system y(+) (SLC7A1 and SLC7A2), with system B(0+) making a minor contribution.	Arginine	22-32	solute carrier family 7 member 2	Rattus norvegicus	158-164
16973217-5	2007	The precision of the technique was checked by injections of the biological dye Pontamine Sky Blue (PSB) or C14-labeled arginine.	Arginine	119-127	anti-Mullerian hormone receptor type 2	Rattus norvegicus	107-110
17105729-2	2007	Lipin harboring the fld(2j) (Gly(84) --&gt; Arg) mutation exhibited relatively little PAP activity.	Arginine	44-47	lipin 1	Mus musculus	20-23
17945002-0	2007	Implication of BRCA2 -26G&gt;A 5" untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg&gt;Pro polymorphism.	Arginine	146-149	BRCA2 DNA repair associated	Homo sapiens	15-20
17116746-4	2007	Arginine 137 was identified in pol beta as an important target for methylation by PRMT1.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	82-87
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Arginine	28-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Arginine	28-36	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-187
16978906-9	2007	In summary, we propose that arginine-glycine-aspartic acid-serine activates Integrin linked kinase via the Phosphoinositol-3 kinase pathway and this leads to activation of c-jun and c-fos and increased Activator protein-1 binding and Transforming growth factor-beta1 promoter activity.	Arginine	28-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-221
17101798-1	2007	The activation of sex-specific alternative splice sites in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on the serine-arginine-rich (SR) splicing factors Tra, Tra2, and Rbp1.	Arginine	169-177	transformer 2	Drosophila melanogaster	210-214
17101798-1	2007	The activation of sex-specific alternative splice sites in the Drosophila melanogaster doublesex and fruitless pre-mRNAs has been well studied and depends on the serine-arginine-rich (SR) splicing factors Tra, Tra2, and Rbp1.	Arginine	169-177	RNA-binding protein 1	Drosophila melanogaster	220-224
18025833-7	2007	RESULTS: Genomic analysis revealed a novel G-to-A transition at the first nucleotide of the 333rd codon of CLCN5, causing a substitution of glycine with arginine.	Arginine	153-161	chloride voltage-gated channel 5	Homo sapiens	107-112
17150099-11	2006	In individuals that were UCP3 T-carriers and ADRB2-16 Arg-carriers the OR increased from 1 in the youngest to 10.84 (95% CI 4.54-25.85) in the oldest.	Arginine	54-57	adrenoceptor beta 2	Homo sapiens	45-50
16981206-3	2006	Three L-arginine-metal coordination interactions are found in metalloenzyme structures deposited in the Protein Data Bank: biotin synthase from E. coli, His-67 --&gt; Arg human carbonic anhydrase I, and inactivated B. caldovelox arginase complexed with L-arginine.	Arginine	6-16	carbonic anhydrase 1	Homo sapiens	177-197
16981206-3	2006	Three L-arginine-metal coordination interactions are found in metalloenzyme structures deposited in the Protein Data Bank: biotin synthase from E. coli, His-67 --&gt; Arg human carbonic anhydrase I, and inactivated B. caldovelox arginase complexed with L-arginine.	Arginine	167-170	carbonic anhydrase 1	Homo sapiens	177-197
16981206-4	2006	In these proteins, L-arginine-metal coordination adopts syn/out-of-plane and anti/in-plane coordination stereochemistry.	Arginine	19-29	synemin	Homo sapiens	56-59
17015411-3	2006	Mesenteric superfusion with exogenous gastrin increased these processes in a concentration- and time-dependent manner, effects prevented by the cholecystokinin (CCK)-2 receptor antagonists (proglumide, L-365,260) but not by the CCK-1 receptor antagonist devazepide.	Arginine	202-204	gastrin	Rattus norvegicus	38-45
17168311-4	2006	Three low-usage ARG codons (CGG or CGA) of gene fragment coding the mature peptide of hBMP7 have been successfully converted into P. pastoris-preferred ARG codons (AGA) by overlap extension PCR-based multiple-site-directed mutagenesis for a high level expression of hBMP7 mature peptide.	Arginine	16-19	bone morphogenetic protein 7	Homo sapiens	86-91
17168311-4	2006	Three low-usage ARG codons (CGG or CGA) of gene fragment coding the mature peptide of hBMP7 have been successfully converted into P. pastoris-preferred ARG codons (AGA) by overlap extension PCR-based multiple-site-directed mutagenesis for a high level expression of hBMP7 mature peptide.	Arginine	16-19	bone morphogenetic protein 7	Homo sapiens	266-271
17168311-4	2006	Three low-usage ARG codons (CGG or CGA) of gene fragment coding the mature peptide of hBMP7 have been successfully converted into P. pastoris-preferred ARG codons (AGA) by overlap extension PCR-based multiple-site-directed mutagenesis for a high level expression of hBMP7 mature peptide.	Arginine	152-155	bone morphogenetic protein 7	Homo sapiens	86-91
17168311-4	2006	Three low-usage ARG codons (CGG or CGA) of gene fragment coding the mature peptide of hBMP7 have been successfully converted into P. pastoris-preferred ARG codons (AGA) by overlap extension PCR-based multiple-site-directed mutagenesis for a high level expression of hBMP7 mature peptide.	Arginine	152-155	bone morphogenetic protein 7	Homo sapiens	266-271
17085964-6	2006	Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the C-terminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP.	Arginine	119-122	lysosomal-associated protein transmembrane 4A	Mus musculus	90-93
17085964-6	2006	Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the C-terminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP.	Arginine	119-122	lysosomal-associated protein transmembrane 4A	Mus musculus	204-208
17024186-3	2006	We identify an arginine/serine-rich region of U2AF 65 that mediates an interaction with an RS-like alternating charge domain of the 59 kDa subunit of the human cleavage factor I (CF I(m)), an essential 3" processing factor that functions at an early step in the recognition of the 3" end processing signal.	Arginine	15-23	complement factor I	Homo sapiens	179-183
16873402-4	2006	beta(2)AR stimulation increased l-arginine transport, as did cyclic AMP elevation with either forskolin or dibutyryl cyclic AMP, and this increase was inhibitable by N-ethylmaleimide.	Arginine	32-42	adrenoceptor beta 2	Homo sapiens	0-9
16873402-6	2006	beta(2)AR stimulation also caused a membrane hyperpolarization inhibitable by l-NAME, suggesting that the increase in l-arginine uptake occurred in response to NO-mediated hyperpolarization.	Arginine	118-128	adrenoceptor beta 2	Homo sapiens	0-9
16873402-8	2006	These findings suggest that beta(2)AR-mediated NOS-3 activation in HUVEC is mediated through phosphorylation of NOS-3 on serine-1177 through both the PKA and the PI3K/Akt systems, and is sustained by an increase in l-arginine uptake resulting from NO-mediated membrane hyperpolarization.	Arginine	215-225	adrenoceptor beta 2	Homo sapiens	28-37
16912044-4	2006	Prevention of SUMO modification by Lys-to-Arg mutation led to an increase not only in the transcriptional activity of RXRalpha but also in the activity of its heterodimeric complex with retinoic acid receptor-alpha or peroxisome proliferator-activated receptor-gamma (PPARgamma).	Arginine	42-45	retinoid X receptor alpha	Homo sapiens	118-126
16793192-2	2006	In the present study, a novel PLA(2) named promutoxin with Arg at the site 49 has been purified from the venom of Protobothrops mucrosquamatus by chromatography.	Arginine	59-62	phospholipase A2 group IIA	Homo sapiens	30-36
16919264-2	2006	In NO-producing cells, L-citrulline can be recycled to L-arginine in a two-step reaction involving argininosuccinate synthase (ASS) and -lyase (ASL).	Arginine	55-65	argininosuccinate lyase	Cavia porcellus	144-147
16861234-2	2006	Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation.	Arginine	35-38	protein arginine methyltransferase 1	Homo sapiens	57-93
16861234-2	2006	Occurrence of histone H4 arginine (Arg) 3 methylation by protein arginine methyltransferase 1 (PRMT1) represents an early promoter event in ER (estrogen receptor)-regulated gene activation.	Arginine	35-38	protein arginine methyltransferase 1	Homo sapiens	95-100
16310306-3	2006	In 293T cells, both TEL/ARG forms co-localized with the cellular beta-actin and were associated with a morphologic change of the cells, consisting in cell rounding and detachment from the tissue culture plastic.	Arginine	24-27	POTE ankyrin domain family member F	Homo sapiens	65-75
16879811-8	2006	Molecular dynamics simulations reveal that the single residue change of L207A impacts the association of TM3 and TM6 in the receptor by altering hydrophobic interactions involving L207, the salt bridge involving the Arg of the DRY motif, and the helical structure of TM6, consistent with events leading to activation.	Arginine	216-219	tropomyosin 3	Homo sapiens	105-108
16879614-5	2006	We found that Ki-1/57 and its putative paralog CGI-55 have two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1.	Arginine	169-177	protein arginine methyltransferase 1	Homo sapiens	193-198
16928472-10	2006	RESULTS: In study 1, significant differences were observed in plasma arginine levels in subjects taking non-timed-release and timed-release AAKG.	Arginine	69-77	protein kinase AMP-activated non-catalytic subunit gamma 2	Homo sapiens	140-144
16928472-11	2006	In study 2, significant differences were observed in the AAKG group (P &lt; 0.05) for 1RM bench press, Wingate peak power, blood glucose, and plasma arginine.	Arginine	149-157	protein kinase AMP-activated non-catalytic subunit gamma 2	Homo sapiens	57-61
16705743-2	2006	Coactivator-associated arginine methyltransferase (CARM1) catalyzes methylation of histone H3 at Arg-17.	Arginine	97-100	coactivator associated arginine methyltransferase 1	Homo sapiens	51-56
17086695-4	2006	RESULTS: There was a small, non-significant decrease in risk for pancreatic cancer in those carrying Gln/Gln genotype at XRCC1 Arg399Gln site (OR 0.64, 95% CI 0.21 - 1.66, P = 0.30) compared with those having Arg/Arg genotypes.	Arginine	127-130	X-ray repair cross complementing 1	Homo sapiens	121-126
17086695-4	2006	RESULTS: There was a small, non-significant decrease in risk for pancreatic cancer in those carrying Gln/Gln genotype at XRCC1 Arg399Gln site (OR 0.64, 95% CI 0.21 - 1.66, P = 0.30) compared with those having Arg/Arg genotypes.	Arginine	209-212	X-ray repair cross complementing 1	Homo sapiens	121-126
16923829-4	2006	We find that lysine to arginine mutations that eliminate the sumoylation of Ndc10 cause chromosome instability, mislocalization of Ndc10 from the mitotic spindle, abnormal anaphase spindles, and a loss of Bir1 sumoylation.	Arginine	23-31	survivin	Saccharomyces cerevisiae S288C	205-209
16671893-1	2006	Human peptidylarginine deiminase type III gene (PADI3) encodes a crucial post-translational modification enzyme that converts protein-bound arginine residues into citrulline residues.	Arginine	14-22	peptidyl arginine deiminase 3	Homo sapiens	48-53
16838115-2	2006	NO is generated from L-arginine by NO synthase (NOS), classified into three isozymes: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS).	Arginine	21-31	nitric oxide synthase 3	Rattus norvegicus	125-140
16923367-4	2006	This study aimed to explore the effects of L-arginine on the expression of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3(IGFBP3)and IGF-I mRNA in brains of IUGR rats and the possible mechanisms of L-arginine.	Arginine	43-53	insulin-like growth factor 2	Rattus norvegicus	111-117
16702225-4	2006	These studies reveal that binding of a pY peptide to the N-SH2 domain of SHP-2 is greatly enhanced by a large hydrophobic residue (Trp, Tyr, Met, or Phe) at the pY+4 and/or pY+5 positions, whereas binding to SHP-1 N-SH2 domain is enhanced by either hydrophobic or positively charged residues (Arg, Lys, or His) at these positions.	Arginine	293-296	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	73-78
16683255-6	2006	There are two mutation hotspots corresponding to arginine residues at positions 124 and 555 of the transforming growth factor beta induced protein (TGFBIp) and they are the most frequent sites of mutation in various populations.	Arginine	49-57	transforming growth factor beta induced	Homo sapiens	148-154
16838788-0	2006	The arginine-rich motif of Bamboo mosaic virus satellite RNA-encoded P20 mediates self-interaction, intracellular targeting, and cell-to-cell movement.	Arginine	4-12	tubulin polymerization promoting protein family member 3	Homo sapiens	69-72
16838788-4	2006	Domain mapping, using the bacterial two-hybrid system, indicated that the self-interacting domain overlaps the RNA-binding domain in the N-terminal arginine-rich motif (ARM) of P20.	Arginine	148-156	tubulin polymerization promoting protein family member 3	Homo sapiens	177-180
16796765-4	2006	We hypothesized that two common single nucleotide polymorphisms of XRCC1 (codons 194 Arg--&gt;Trp and 399 Arg--&gt;Gln) are related to the risk of NPC and interact with tobacco smoking.	Arginine	85-88	X-ray repair cross complementing 1	Homo sapiens	67-72
16796765-4	2006	We hypothesized that two common single nucleotide polymorphisms of XRCC1 (codons 194 Arg--&gt;Trp and 399 Arg--&gt;Gln) are related to the risk of NPC and interact with tobacco smoking.	Arginine	106-109	X-ray repair cross complementing 1	Homo sapiens	67-72
16800733-6	2006	All synthetic substrates tested containing either arginine or lysine at P1 position were cleaved by hK8.	Arginine	50-58	keratin 8	Homo sapiens	100-103
16858129-4	2006	A SNP (30,398 C&gt;T) in the FMO3 gene causing a stop codon at Arg(500) in exon 9 was also discovered.	Arginine	63-66	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	29-33
16703566-7	2006	The increase in arginine transport during activation, but not proliferation, was mediated by the SLC7A2/Cat2 gene.	Arginine	16-24	dominant cataract 2	Mus musculus	104-108
16699006-6	2006	Multiple arginines in the 325-376 region were methylated in vitro by PRMT1 and PRMT5, as was an N-terminal Gly-Arg-rich region between amino acids 41 and 50.	Arginine	9-18	protein arginine methyltransferase 1	Homo sapiens	69-74
16522630-8	2006	To determine whether syntaxin with arginine instead of glutamine in its zero layer can support SNARE function in vivo, we introduced it as a transgene into a Caenorhabditis elegans syntaxin-null strain.	Arginine	35-43	t-SNARE coiled-coil homology domain-containing protein	Caenorhabditis elegans	21-29
16522630-9	2006	Mutant syntaxin rescued viability and locomotory defects similarly to wild-type syntaxin, demonstrating that SNARE complexes with two glutamines and two arginines in the zero layer can support neurotransmission.	Arginine	153-162	t-SNARE coiled-coil homology domain-containing protein	Caenorhabditis elegans	7-15
16634636-1	2006	The Gly380 --&gt; Arg mutation in the TM domain of fibroblast growth factor receptor 3 (FGFR3) of the RTK family is linked to achondroplasia, the most common form of human dwarfism.	Arginine	18-21	fibroblast growth factor receptor 3	Homo sapiens	51-86
16634636-1	2006	The Gly380 --&gt; Arg mutation in the TM domain of fibroblast growth factor receptor 3 (FGFR3) of the RTK family is linked to achondroplasia, the most common form of human dwarfism.	Arginine	18-21	fibroblast growth factor receptor 3	Homo sapiens	88-93
16371438-8	2006	In response to GM-CSF treatment, transport activity increased mostly through system y(+) (&gt;10-fold), accounting for about 40% of the total L-arginine transport.	Arginine	142-152	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	15-21
16371438-10	2006	Furthermore, GM-CSF induced an increase in arginase activity and in the conversion of L-arginine to ornithine, citrulline, glutamate, proline, and polyamines.	Arginine	86-96	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	13-19
16371438-13	2006	We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell.	Arginine	84-94	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	76-82
16371438-13	2006	We conclude that BMM present mainly y(+)L activity and that, in response to GM-CSF, l-arginine transport augments through CAT2, thereby increasing the availability of this amino acid to the cell.	Arginine	84-94	dominant cataract 2	Mus musculus	122-126
16332725-4	2006	The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively.	Arginine	9-12	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-8
16332725-4	2006	The ADH2 Arg allele was found to be associated with increased risk, the odds ratios (ORs) being 1.35 (95% confidence interval: 1.00-1.84) and 1.93 (1.06-3.53) for the His/Arg and Arg/Arg genotypes, respectively.	Arginine	171-174	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	4-8
16702384-5	2006	ADH2 His/Arg and Arg/Arg genotypes showed higher risk for habitual drinking.	Arginine	9-12	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	0-4
16702384-8	2006	The combination genotypes of two polymorphisms revealed the clear effect of the ADH2 Arg allele among those with ALDH2 Glu/Lys in both sexes (P(trend) = 0.007 for men and 0.024 for women).	Arginine	85-88	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	80-84
16702384-10	2006	Heavy drinker status was also strongly associated with ADH2 Arg alleles.	Arginine	60-63	alcohol dehydrogenase 1B (class I), beta polypeptide	Homo sapiens	55-59
16596194-3	2006	Two alternatively spliced IGF1R mRNA transcripts have been described to differ by only three nucleotides (CAG) in the coding sequence, resulting in an amino-acid change from the originally described Thr-Gly to an Arg in the extracellular portion of the receptor beta subunit.	Arginine	213-216	insulin like growth factor 1 receptor	Homo sapiens	26-31
16618121-3	2006	In support of this, the substitution of Arg-150 of fXa with Ala (R150A) impaired the reactivity of the mutant with AT by 1 order of magnitude specifically in the presence H5.	Arginine	40-43	coagulation factor X	Homo sapiens	51-54
16492668-0	2006	Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src.	Arginine	11-19	protein arginine methyltransferase 1	Homo sapiens	82-118
16492668-7	2006	Methylation of arginine residues by protein-arginine methyltransferase 1 did not influence the RNA-binding activity, the translation inhibitory function, or the cellular localization of hnRNP K but reduced the interaction of hnRNP K with the tyrosine kinase c-Src.	Arginine	15-23	protein arginine methyltransferase 1	Homo sapiens	36-72
16584176-5	2006	A high K(m) value of R458Q for ADX concentration and a decrease of rate constant of the first electron transfer seem reasonable considering that the conversion from Arg to noncharged Gln abolishes salt-bridge formation with the acidic residue of ADX.	Arginine	165-168	ferredoxin 1	Homo sapiens	31-34
16584176-5	2006	A high K(m) value of R458Q for ADX concentration and a decrease of rate constant of the first electron transfer seem reasonable considering that the conversion from Arg to noncharged Gln abolishes salt-bridge formation with the acidic residue of ADX.	Arginine	165-168	ferredoxin 1	Homo sapiens	246-249
16511838-5	2006	One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects.	Arginine	129-137	UDP glycosyltransferase 8	Homo sapiens	91-94
16511838-5	2006	One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT --> CAT:485G > A) resulting in an arginine-to-histidine (Arg --> His) change, was detected in these subjects.	Arginine	152-155	UDP glycosyltransferase 8	Homo sapiens	91-94
16332251-6	2006	In Xenopus laevis oocytes and human U373MG glioblastoma cells, hCAT-3-mediated L-arginine transport was significantly reduced upon treatment with compounds that activate classical PKC.	Arginine	79-89	solute carrier family 7 member 3	Homo sapiens	63-69
16440001-3	2006	Ku70 is cut after Arg(301), disrupting Ku complex binding to DNA.	Arginine	18-21	X-ray repair cross complementing 6	Homo sapiens	0-4
16357042-0	2006	Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells.	Arginine	0-8	aldo-keto reductase family 1, member C14	Rattus norvegicus	52-58
16357042-0	2006	Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells.	Arginine	0-8	aldo-keto reductase family 1, member C14	Rattus norvegicus	70-105
16256245-4	2006	Modification of cysteine by introducing either a methyl or t-butyl group in the free sulfhydryl group and replacing the guanidine group with a urea linkage in the side chain of arginine in the cysteine-rich and arginine-rich Tat peptide sequences completely blocked the ability of these peptides to induce HIV replication, chemokine receptor CCR-5 expression, and NF-kappaB activity in monocytes.	Arginine	177-185	C-C motif chemokine receptor 5	Homo sapiens	342-347
16421101-1	2006	The oxygenase domain of inducible nitric-oxide synthase exists as a functional tight homodimer in the presence of the substrate L-arginine and the cofactor tetrahydrobiopterin (H4B).	Arginine	128-138	H4 clustered histone 4	Homo sapiens	177-180
16442499-4	2006	Other superfamily I helicases such as, UvrD/Rep/PcrA also possess these residues but in addition they interact with adenine via a conserved arginine, which is replaced by a serine in helicase IV.	Arginine	140-148	replication protein	Escherichia coli	44-47
16339204-3	2006	Similar deficits were observed with arginine-stimulated insulin secretion.	Arginine	36-44	LOC105613195	Ovis aries	56-63
16321554-3	2006	The enzymatic activity of NAGS increases in the presence of arginine.	Arginine	60-68	N-acetylglutamate synthase	Homo sapiens	26-30
16321554-4	2006	Since the level of NAGS activity depends on the concentrations of two amino acids, glutamate and arginine, and it supplies the essential cofactor for CPSI, NAGS may play an important role in the regulation of ureagenesis.	Arginine	97-105	N-acetylglutamate synthase	Homo sapiens	19-23
16321554-4	2006	Since the level of NAGS activity depends on the concentrations of two amino acids, glutamate and arginine, and it supplies the essential cofactor for CPSI, NAGS may play an important role in the regulation of ureagenesis.	Arginine	97-105	N-acetylglutamate synthase	Homo sapiens	156-160
16339181-1	2006	In humans, subjects homozygous for arginine (ArgArg) at codon 16 of the beta2-adrenergic receptor (beta2AR) have been shown to have greater agonist-mediated desensitization than subjects homozygous for glycine (GlyGly).	Arginine	35-43	adrenoceptor beta 2	Homo sapiens	72-97
16339181-1	2006	In humans, subjects homozygous for arginine (ArgArg) at codon 16 of the beta2-adrenergic receptor (beta2AR) have been shown to have greater agonist-mediated desensitization than subjects homozygous for glycine (GlyGly).	Arginine	35-43	adrenoceptor beta 2	Homo sapiens	99-106
16339181-8	2006	These data suggest that subjects homozygous for Arg at codon 16 of the beta2AR have reduced and MAP at rest that persist during exercise with no evidence for differential changes over the course of exercise despite large changes in catecholamines.	Arginine	48-51	adrenoceptor beta 2	Homo sapiens	71-78
16155089-9	2006	Thus, in these iNOS-transfected bPAEC, the transfected iNOS and native arginase compete for a common intracellular pool of L-Arg.	Arginine	123-128	nitric oxide synthase 2	Bos taurus	15-19
16155089-9	2006	Thus, in these iNOS-transfected bPAEC, the transfected iNOS and native arginase compete for a common intracellular pool of L-Arg.	Arginine	123-128	nitric oxide synthase 2	Bos taurus	55-59
16470315-6	2006	The magnitude of 300 nM CCK-8S-induced relaxation was reduced by 100 microM L-NOARG from 73 +/- 5.1 to 19 +/- 3.5% in an L-arginine but not D-arginine preventable manner.	Arginine	121-131	cholecystokinin	Rattus norvegicus	24-27
16230338-10	2006	The current crystal structure of SC-(1-325).bovine thrombin reveals that SC would dock similarly to the bovine proenzyme, whereas the bovine (pro)thrombin-characteristic residues Arg(144) and Arg(145) would likely interfere with insertion of the SC N terminus, thus explaining the greatly reduced activation of bovine ProT.	Arginine	179-182	coagulation factor II, thrombin	Bos taurus	146-154
16230338-10	2006	The current crystal structure of SC-(1-325).bovine thrombin reveals that SC would dock similarly to the bovine proenzyme, whereas the bovine (pro)thrombin-characteristic residues Arg(144) and Arg(145) would likely interfere with insertion of the SC N terminus, thus explaining the greatly reduced activation of bovine ProT.	Arginine	192-195	coagulation factor II, thrombin	Bos taurus	51-59
16278211-5	2006	We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds.	Arginine	212-220	ADP-ribosylarginine hydrolase	Homo sapiens	40-44
16388607-4	2006	We found that a major binding region of pre-VII with both DNA and the acidic carboxyl-terminal region of TAF-I lies in the arginine-rich region of pre-VII.	Arginine	123-131	SET nuclear proto-oncogene	Homo sapiens	105-110
16388607-6	2006	A TAF-I mutant protein lacking the acidic carboxyl-terminal region bound preferentially to the carboxyl-terminal region of pre-VII containing the arginine-rich region rather than the amino-terminal region of pre-VII.	Arginine	146-154	SET nuclear proto-oncogene	Homo sapiens	2-7
16809898-3	2006	L-arg is converted to urea by arginase I in the liver and arginase II in the kidney.	Arginine	0-5	arginase 2	Rattus norvegicus	58-69
16717448-6	2006	For ANXA9 one SNP was located in exon 5 (A--&gt;G 951) resulting in an amino acid change from histidine to arginine.	Arginine	107-115	annexin A9	Bos taurus	4-9
16205964-2	2006	The TK inhibitor imatinib mesylate selectively targets PDGFR-alpha, -beta, c-kit, c-abl and arg and has proven successful in the treatment of chronic myeloid leukaemia.	Arginine	48-51	TXK tyrosine kinase	Homo sapiens	4-6
16205964-2	2006	The TK inhibitor imatinib mesylate selectively targets PDGFR-alpha, -beta, c-kit, c-abl and arg and has proven successful in the treatment of chronic myeloid leukaemia.	Arginine	48-51	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	82-87
16205964-10	2006	We show here for the first time in a large series of glioblastomas that PDGFR-alpha, -beta, c-kit, c-abl and arg expression is immunohistochemically detectable in a fraction of cases.	Arginine	38-41	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	99-104
16541190-2	2006	Recently, it has been demonstrated that arginase and arginine decarboxylase (ADC), two enzymes that also employ arginine as a substrate, may regulate NOS activity.	Arginine	53-61	antizyme inhibitor 2	Rattus norvegicus	77-80
16189298-7	2006	The JuPBR gene showed two single-nucleotide polymorphisms resulting in the two substitutions, Ala147 --&gt; threonine and His162 --&gt; arginine, of PBR amino acidic sequence.	Arginine	136-144	translocator protein	Homo sapiens	6-9
17135210-5	2006	Surprisingly, Tra, Tra2 and 9G8 are much stronger splicing activators than other SR protein family members and their activation potential is significantly higher than expected from their serine/arginine content.	Arginine	194-202	transformer 2	Drosophila melanogaster	19-23
16338791-3	2005	In acute experiments, epiregulin was able to potentiate insulin release in the presence of glucose or arginine, in the two cell lines.	Arginine	102-110	epiregulin	Rattus norvegicus	22-32
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	0-8	KRAS proto-oncogene, GTPase	Homo sapiens	39-42
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	99-135
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	137-142
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	44-52	KRAS proto-oncogene, GTPase	Homo sapiens	39-42
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	44-52	protein arginine methyltransferase 1	Homo sapiens	99-135
16306605-5	2005	Arginine 467 in the helicase domain of NS3 (arginine 1493 in the polyprotein) can be methylated by protein arginine methyltransferase 1 (PRMT1).	Arginine	44-52	protein arginine methyltransferase 1	Homo sapiens	137-142
16135369-0	2005	delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway.	Arginine	129-139	5'-nucleotidase, cytosolic II	Homo sapiens	160-163
15993513-2	2005	A series of tetrapeptides, based on Tic-DPhe-Arg-Trp-NH2-a mimic of the putative message sequence "His-Phe-Arg-Trp" and modified at the DPhe position, were prepared and pharmacologically characterized for potency and selectivity.	Arginine	45-48	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	36-39
16205319-5	2005	WBH induced apoptosis, as indicated by DNA fragmentation, and increased levels of p53 and caspase-3 activity, which were significantly reduced by the administration of L-arg.	Arginine	168-173	caspase 3	Mus musculus	90-99
16279843-4	2005	Recently, a single-nucleotide polymorphism (SNP), encoding a functional arginine to tryptophan residue change at PTPN22 codon 620 in Caucasians has been shown to be associated with GD and other autoimmune diseases.	Arginine	72-80	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	113-119
16159817-0	2005	Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction.	Arginine	11-21	fibroblast growth factor 2	Sus scrofa	25-51
15992770-1	2005	We have recently cloned a new member of the human Ser/Arg-rich superfamily (SR) of pre-mRNA splicing factors, SR-A1.	Arginine	54-57	steroid receptor RNA activator 1	Homo sapiens	110-115
15839837-3	2005	Hepsin exhibited strong preference at the P1 position for arginine over lysine, and favoured threonine, leucine or asparagine at the P2, glutamine or lysine at the P3, and proline or lysine at the P4 position.	Arginine	58-66	hepsin	Homo sapiens	0-6
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Arginine	87-90	coagulation factor X	Homo sapiens	58-61
16042383-2	2005	There are 11 charged residues in the 82-116 loop of human fXa (Glu-84, Glu-86, Lys-90, Arg-93, Lys-96, Glu-97, Asp-100, Asp-102, Arg-107, Lys-109, and Arg-115).	Arginine	129-132	coagulation factor X	Homo sapiens	58-61
15976236-11	2005	Furthermore, this catecholamine-enhanced L-arginine transport might involve CAT-1 and CAT-2A but not CAT-2 or CAT-2B.	Arginine	41-51	dominant cataract 2	Mus musculus	86-91
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	38-46	protein arginine methyltransferase 1	Homo sapiens	112-148
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	38-46	protein arginine methyltransferase 1	Homo sapiens	150-155
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	82-90	protein arginine methyltransferase 1	Homo sapiens	112-148
15970667-3	2005	Recently, we have shown that MRE11 is arginine methylated in a C-terminal glycine-arginine rich (GAR) domain by protein arginine methyltransferase 1 (PRMT1).	Arginine	82-90	protein arginine methyltransferase 1	Homo sapiens	150-155
15970667-6	2005	We also demonstrate that PRMT1 is a component of PML nuclear bodies where it colocalizes with MRE11.Using cellular fractionation, we demonstrate that methylated MRE11 is predominantly associated with nuclear structures and that MRE11 methylated arginines were required for this association.	Arginine	245-254	protein arginine methyltransferase 1	Homo sapiens	25-30
15805225-9	2005	Because arginine-based intracellular retention signals of the type RXR, where X represents any amino acid, are used to regulate assembly and surface transport of several multimeric complexes, such a mechanism may apply to other proteins as well.	Arginine	8-16	retinoid X receptor alpha	Homo sapiens	67-70
15964996-2	2005	We report here that PGC-1alpha coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator.	Arginine	70-78	protein arginine methyltransferase 1	Homo sapiens	94-130
15964996-2	2005	We report here that PGC-1alpha coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator.	Arginine	70-78	protein arginine methyltransferase 1	Homo sapiens	132-137
15964996-3	2005	Mutation of three substrate arginines in the C-terminal region of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compromised the ability of PGC-1alpha to induce endogenous target genes.	Arginine	28-37	protein arginine methyltransferase 1	Homo sapiens	142-147
15826948-5	2005	Here we provide several independent lines of evidence indicating that the issue of arginine methylation of STATs has to be reassessed.	Arginine	83-91	signal transducer and activator of transcription 1	Homo sapiens	107-112
15826948-8	2005	Third, we show that mutation of Arg(31) to Lys led to destabilization of STAT1 and STAT3, implicating an important structural role of Arg(31).	Arginine	32-35	signal transducer and activator of transcription 1	Homo sapiens	73-78
15656789-8	2005	Experiments with an increasing concentration (0- 40 mM) of [guanidino-15N2]arginine showed a Michaelis constant Km for arginine of 46 mM and a Vmax of 3.7 nmol x min(-1) x (mg of protein)(-1) for flux through the ADC reaction.	Arginine	75-83	antizyme inhibitor 2	Rattus norvegicus	213-216
16101009-8	2005	At the P2" position, TACE can accommodate basic amino acids, such as arginine and lysine, as well as certain non-basic amino acids such as citrulline, methionine sulfoxide and threonine.	Arginine	69-77	ADAM metallopeptidase domain 17	Homo sapiens	21-25
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Arginine	26-34	Rab escort protein	Arabidopsis thaliana	80-83
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Arginine	26-34	Rab escort protein	Arabidopsis thaliana	192-198
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Arginine	26-34	Rab escort protein	Arabidopsis thaliana	161-164
15854662-7	2005	We found that a conserved arginine residue, R195, known to be crucial for yeast REP function, is substituted by an asparagine or threonine residue in angiosperm REPs. A point mutant allele of AthREP with arginine at this position complemented the yeast REP mutation, while wild-type AthREP did not.	Arginine	204-212	Rab escort protein	Arabidopsis thaliana	192-198
15809046-2	2005	Belgrade rats have a glycine-to-arginine (G185R) mutation in DMT1, which affects its function.	Arginine	32-40	RoBo-1	Rattus norvegicus	61-65
15617517-4	2005	By using a series of recombinant FXa mutants in which the HBE is mutated, we have identified the importance of amino acids involved in the enzyme-inhibitor interaction as being in the following order: Arg-93&gt;&gt;Arg-165&gt; or =Lys-169&gt;Lys-236&gt;Lys-96&gt;Arg-240&gt;Arg-125.	Arginine	215-218	coagulation factor X	Homo sapiens	33-36
15849449-11	2005	L-arginine also downregulated the expressions of tissue inhibitor of metalloproteinase-1 mRNA and metalloproteinase-1 mRNA, as well as the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 (p&lt;0.05).	Arginine	0-10	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	49-88
15849449-11	2005	L-arginine also downregulated the expressions of tissue inhibitor of metalloproteinase-1 mRNA and metalloproteinase-1 mRNA, as well as the ratio of tissue inhibitor of metalloproteinase-1/metalloproteinase-1 (p&lt;0.05).	Arginine	0-10	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	148-187
15864128-7	2005	Genetic analysis of ABCC2 identified a heterozygous mutation replacing a highly conserved arginine by glycine in the cytoplasmic part of the second membrane-spanning domain (position 412 of MRP2), a region associated with substrate affinity.	Arginine	90-98	ATP binding cassette subfamily C member 2	Homo sapiens	20-25
15864128-7	2005	Genetic analysis of ABCC2 identified a heterozygous mutation replacing a highly conserved arginine by glycine in the cytoplasmic part of the second membrane-spanning domain (position 412 of MRP2), a region associated with substrate affinity.	Arginine	90-98	ATP binding cassette subfamily C member 2	Homo sapiens	190-194
15780765-11	2005	In summary, arginase-1 overexpression leads to upregulated CAT-1 expression in psoriatic skin, which is due to lowered intracellular l-arginine levels and limits NO synthesis at physiological l-arginine concentrations.	Arginine	133-143	solute carrier family 7 member 1	Homo sapiens	59-64
15780765-11	2005	In summary, arginase-1 overexpression leads to upregulated CAT-1 expression in psoriatic skin, which is due to lowered intracellular l-arginine levels and limits NO synthesis at physiological l-arginine concentrations.	Arginine	192-202	solute carrier family 7 member 1	Homo sapiens	59-64
15735735-6	2005	The results further demonstrate that c-Abl-mediated phosphorylation of Arg on Y-261 similarly confers Arg stabilization.	Arginine	71-74	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-42
15735735-6	2005	The results further demonstrate that c-Abl-mediated phosphorylation of Arg on Y-261 similarly confers Arg stabilization.	Arginine	102-105	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-42
15771721-1	2005	A single nucleotide polymorphism (SNP) in the corticotrophin-releasing hormone gene (CRH C22G) alters the fourth amino acid in the signal sequence from proline to arginine.	Arginine	163-171	corticotropin releasing hormone	Bos taurus	85-88
15527420-7	2005	Recombinant C1r-LP exhibits esterolytic activity against peptide thioesters with arginine at the P1 position, but its catalytic efficiency (kcat/K(m)) is lower than that of C1r and C1s.	Arginine	81-89	complement C1r subcomponent like	Homo sapiens	12-18
15729383-9	2005	When expressed in CHO cells, wild-type TEL/ARG induced the formation of fillopodia, in a fashion dependent on the C-terminal portion and intact kinase activity.	Arginine	43-46	ets variant 6	Mus musculus	39-42
15729383-10	2005	Thus, these results suggest several critical domains within TEL/ARG necessary for function, and indicate that the signaling pathways necessary for viability, growth factor hyper-responsiveness and cytoskeletal reorganization are likely to be separate.	Arginine	64-67	ets variant 6	Mus musculus	60-63
15741314-0	2005	Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.	Arginine	0-8	protein arginine methyltransferase 1	Homo sapiens	33-38
15741314-2	2005	Herein we show that the MRE11 checkpoint protein is arginine methylated by PRMT1.	Arginine	52-60	protein arginine methyltransferase 1	Homo sapiens	75-80
15731352-4	2005	Here, we report that CARM1 also methylates Arg-2142 within the C-terminal GRIP1 binding domain (GBD) of p300.	Arginine	43-46	coactivator associated arginine methyltransferase 1	Homo sapiens	21-26
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Arginine	82-85	prepronociceptin	Mus musculus	47-52
15509719-1	2005	A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency.	Arginine	82-85	prepronociceptin	Mus musculus	98-103
15761336-7	2005	Arginine and glutamine had no differential effect on NF-kappaB, whereas AP-1 expression (c-jun but not c-fos) was markedly enhanced by arginine and significantly lessened by glutamine.	Arginine	135-143	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-76
15761336-7	2005	Arginine and glutamine had no differential effect on NF-kappaB, whereas AP-1 expression (c-jun but not c-fos) was markedly enhanced by arginine and significantly lessened by glutamine.	Arginine	135-143	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-94
15761336-8	2005	CONCLUSION: Arginine enhanced expression of the early proinflammatory transcription factor AP-1 but not NF-kappaB.	Arginine	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
15572357-0	2005	The Met-196 -&gt; Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.	Arginine	18-21	TNF receptor superfamily member 1B	Homo sapiens	41-73
15572357-0	2005	The Met-196 -&gt; Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.	Arginine	18-21	TNF receptor superfamily member 1B	Homo sapiens	75-80
15572357-2	2005	A polymorphism in the TNF receptor 2 (TNFR2) gene resulting in a juxtamembrane inversion from methionine (TNFR2(196MET)) to arginine (TNFR2(196ARG)) has been genetically associated with an increased risk for systemic lupus erythematosus and familial rheumatoid arthritis.	Arginine	124-132	TNF receptor superfamily member 1B	Homo sapiens	22-36
15572357-2	2005	A polymorphism in the TNF receptor 2 (TNFR2) gene resulting in a juxtamembrane inversion from methionine (TNFR2(196MET)) to arginine (TNFR2(196ARG)) has been genetically associated with an increased risk for systemic lupus erythematosus and familial rheumatoid arthritis.	Arginine	124-132	TNF receptor superfamily member 1B	Homo sapiens	38-43
15483229-9	2005	Furthermore, we provide evidence that extracellular L-arginine is a crucial requirement for normal PC Cl3 cell growth and that long-term L-arginine deprivation negatively influences CAT-2B expression, as it correlates to reduction of CAT-2B mRNA levels.	Arginine	137-147	solute carrier family 7 member 2	Rattus norvegicus	182-188
15734955-3	2005	Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg--&gt;Trp and 399 Arg--&gt;Gln) influence breast cancer susceptibility and interact with polycyclic aromatic hydrocarbon (PAH)-DNA adducts, cigarette smoking, and intake of fruits and vegetables and antioxidants.	Arginine	186-189	X-ray repair cross complementing 1	Homo sapiens	169-174
15734955-3	2005	Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg--&gt;Trp and 399 Arg--&gt;Gln) influence breast cancer susceptibility and interact with polycyclic aromatic hydrocarbon (PAH)-DNA adducts, cigarette smoking, and intake of fruits and vegetables and antioxidants.	Arginine	207-210	X-ray repair cross complementing 1	Homo sapiens	169-174
15561099-8	2005	Both CAPON and utrophin protein levels increased in dystrophic quadriceps muscle after treatment with the steroid deflazacort plus L-arginine, known to reduce the dystrophic phenotype.	Arginine	131-141	utrophin	Homo sapiens	15-23
15561099-9	2005	The identification of CAPON transcripts and protein in mammalian muscle and responses to L-arginine suggest CAPON may have a functional role in stabilizing neuronal NOS in skeletal muscle in the cytoskeletal complex associated with dystrophin/utrophin, with possible applications to therapy for human muscular dystrophy.	Arginine	89-99	utrophin	Homo sapiens	243-251
15504745-8	2005	A chimeric Rac1 protein in which the Rac1 C-terminal polybasic domain, which contains six lysines or arginines, was replaced with that of the human Rac2 polybasic domain containing only three basic residues, also reconstituted superoxide production and chemotaxis, whereas expression of a Rac2 derivative in which the polybasic domain was replaced with that of Rac1 did not and resulted in disoriented cell motility.	Arginine	101-110	Rac family small GTPase 1	Homo sapiens	11-15
15504745-8	2005	A chimeric Rac1 protein in which the Rac1 C-terminal polybasic domain, which contains six lysines or arginines, was replaced with that of the human Rac2 polybasic domain containing only three basic residues, also reconstituted superoxide production and chemotaxis, whereas expression of a Rac2 derivative in which the polybasic domain was replaced with that of Rac1 did not and resulted in disoriented cell motility.	Arginine	101-110	Rac family small GTPase 1	Homo sapiens	37-41
15504745-8	2005	A chimeric Rac1 protein in which the Rac1 C-terminal polybasic domain, which contains six lysines or arginines, was replaced with that of the human Rac2 polybasic domain containing only three basic residues, also reconstituted superoxide production and chemotaxis, whereas expression of a Rac2 derivative in which the polybasic domain was replaced with that of Rac1 did not and resulted in disoriented cell motility.	Arginine	101-110	Rac family small GTPase 1	Homo sapiens	37-41
15567420-11	2005	We speculated that this difference was due to the substitution of three acidic residues by alanine, serine, and arginine in the LTBP-4 sequence.	Arginine	112-120	latent transforming growth factor beta binding protein 4	Homo sapiens	128-134
15620686-6	2005	The N-terminal arginine on RPPGF binds to the P2 position or proline46 on PAR4 to block thrombin cleavage.	Arginine	15-23	F2R like thrombin or trypsin receptor 3	Homo sapiens	74-78
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	106-114	argininosuccinate synthase 1	Rattus norvegicus	44-70
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	116-121	argininosuccinate synthase 1	Rattus norvegicus	44-70
15588718-1	2005	This study investigates our hypothesis that argininosuccinate synthase (AS), the rate-limiting enzyme for arginine (L-arg) regeneration from citrulline (L-cit), plays a pivotal role in supplying L-arg to endothelial (eNOS), but not inducible (iNOS) nitric oxide synthase, for nitric oxide (NO) production.	Arginine	195-200	argininosuccinate synthase 1	Rattus norvegicus	44-70
15598509-5	2005	The CO-related modes in the CO-bound ferrous enzyme are sensitive to the presence of substrate, either L-arginine or N-hydroxy-L-arginine, in the distal pocket, but insensitive to the presence of the tetrahydrobiopterin (H4B) cofactor.	Arginine	103-113	H4 clustered histone 4	Homo sapiens	221-224
15953819-6	2005	P2Y2 receptors, via an RGD (Arg-Gly-Asp) motif in their first extracellular loop, bind to alphavbeta3/beta5 integrins, whereupon P2Y2 receptor activation stimulates integrin signaling pathways that regulate cytoskeletal reorganization and cell motility.	Arginine	28-31	purinergic receptor P2Y2	Homo sapiens	0-4
15953819-6	2005	P2Y2 receptors, via an RGD (Arg-Gly-Asp) motif in their first extracellular loop, bind to alphavbeta3/beta5 integrins, whereupon P2Y2 receptor activation stimulates integrin signaling pathways that regulate cytoskeletal reorganization and cell motility.	Arginine	28-31	purinergic receptor P2Y2	Homo sapiens	129-133
15542855-4	2004	While the bulk of Hrp1p, Nab2p, or Mex67p is not associated with polysome containing mRNAs, significant amounts of the serine/arginine (SR)-type shuttling mRNA binding proteins Npl3p, Gbp2p, and Hrb1p remain associated with the mRNA-protein complex during translation.	Arginine	126-134	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	177-182
15588347-5	2004	The critical role of the Arg residue in this motif was determined using viruses pseudotyped with the envelope of primary isolate CA1 containing the GPGR motif or with a mutated envelope with a Gln (Q) replacing the Arg (R) at the tip of the loop.	Arginine	25-28	carbonic anhydrase 1	Homo sapiens	129-132
15326173-0	2004	Type II metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana cleave substrates after arginine and lysine.	Arginine	85-93	metacaspase 4	Arabidopsis thaliana	21-26
15215243-9	2004	The mTP requires neither arginine residues nor predictable alpha-helices for efficient mitochondrial targeting.	Arginine	25-33	lysosomal-associated protein transmembrane 4A	Mus musculus	4-7
15292262-9	2004	Mutation of the conserved Arg in the ligand binding site of Siglec-7 (Arg124) or Siglec-9 (Arg120) resulted in reduced inhibitory function in the NFAT/luciferase transcription assay, suggesting that ligand binding is required for optimal inhibition of TCR signaling.	Arginine	26-29	sialic acid binding Ig like lectin 9	Homo sapiens	81-89
15623213-7	2004	In these SNPs, one mutation in exon 5 (A2355G) led to the change of amino acid from glutamine to arginine (Gln 113 Arg): as a result a different ghrelin precursor instead of a mature peptide was produced.	Arginine	97-105	ghrelin/obestatin prepropeptide	Gallus gallus	145-152
15465786-3	2004	The renal enzymes of arginine synthesis, argininosuccinate synthetase and argininosuccinate lyase, occur in the cells of the proximal tubule.	Arginine	21-29	argininosuccinate lyase	Homo sapiens	74-97
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	signal transducer and activator of transcription 1	Homo sapiens	190-195
15543946-7	2004	Furthermore, mutation of arginine 1113 prevented the following angiotensin II-dependent processes from occurring: (1) Jak2 tyrosine phosphorylation, (2) Jak2/AT1receptor co-association, (3) STAT1 recruitment to the Jak2/AT1receptor complex, (4) STAT1 tyrosine phosphorylation, and (5) STAT-mediated gene expression.	Arginine	25-33	signal transducer and activator of transcription 1	Homo sapiens	245-250
15368334-6	2004	Individuals having the genotype of the arginine/glutamine polymorphism at codon 399 in the XRCC1 gene (R399) showed a nonsignificant increased risk of breast carcinoma compared with those without (OR, 1.4; 95% CI, 0.7-2.7), and a nonsignificant decreased risk against a subsequent thyroid carcinoma (OR, 0.6; 95% CI, 0.2-1.6).	Arginine	39-47	X-ray repair cross complementing 1	Homo sapiens	91-96
15334382-1	2004	We examined the effects of combined genotypes of the beta(2)-adrenergic receptor (AR) Arg(16)-Gly and beta(3)-AR Trp(64)-Arg polymorphisms on longitudinal serum total (T-C) and low-density lipoprotein cholesterol (LDL-C) profiles in 1,198 subjects examined multiple times (6,488 observations) from 1973 to 1996 in the Bogalusa Heart Study, at ages from 4.5 to 38 years.	Arginine	86-89	adrenoceptor beta 2	Homo sapiens	82-84
15334382-2	2004	Within 5-year age groups, T-C was significantly (P &lt;.05) higher in beta(2)-AR Arg(16)/Arg(16) homozygotes than in Gly(16) carriers among those 4 to 8 (171.4 +/- 30.0 v 161.5 +/- 27.7 mg/dL), 9 to 13 (167.7 +/- 28.6 v 162.4 +/- 27.4 mg/dL), and 14 to 18 (158.8 +/- 29.6 v 154.7 +/- 27.5 mg/dL) years of age, but not in those 19 to 23, 24 to 28, 29 to 33, or 34 to 38 years of age.	Arginine	81-84	adrenoceptor beta 2	Homo sapiens	70-80
15159396-2	2004	Although both enzymes prefer Arg at P(1) and basic residues at P(2), the two differ in recognition of P(4) and P(6) residues.	Arginine	29-32	crystallin gamma F, pseudogene	Homo sapiens	36-40
15289616-4	2004	Mcm1p and Arg80p were found in a soluble complex lacking Arg81p and Arg82p, and both Mcm1p and Arg80p were efficiently recruited to ARG1 in wild-type cells in the presence or absence of exogenous arginine, and also in arg81Delta cells.	Arginine	196-204	serum response factor	Homo sapiens	0-5
15289616-4	2004	Mcm1p and Arg80p were found in a soluble complex lacking Arg81p and Arg82p, and both Mcm1p and Arg80p were efficiently recruited to ARG1 in wild-type cells in the presence or absence of exogenous arginine, and also in arg81Delta cells.	Arginine	196-204	serum response factor	Homo sapiens	85-90
15555397-4	2004	RESULTS: The frequencies of Arg/Arg, Arg/Trp and Trp/Trp genotypes at XRCC1 Arg194Trp site were 47.6%, 49.5% and 2.9% among cases compared to 45.7%, 48.6% and 5.7% among controls.	Arginine	28-31	X-ray repair cross complementing 1	Homo sapiens	70-75
15555397-4	2004	RESULTS: The frequencies of Arg/Arg, Arg/Trp and Trp/Trp genotypes at XRCC1 Arg194Trp site were 47.6%, 49.5% and 2.9% among cases compared to 45.7%, 48.6% and 5.7% among controls.	Arginine	32-35	X-ray repair cross complementing 1	Homo sapiens	70-75
15555397-4	2004	RESULTS: The frequencies of Arg/Arg, Arg/Trp and Trp/Trp genotypes at XRCC1 Arg194Trp site were 47.6%, 49.5% and 2.9% among cases compared to 45.7%, 48.6% and 5.7% among controls.	Arginine	32-35	X-ray repair cross complementing 1	Homo sapiens	70-75
15555397-6	2004	The frequencies of Arg/Arg, Arg/Gln and Gln/Gln genotypes at XRCC1 Arg399Gln site were 46.7%, 41.9% and 11.4% among cases, while 54.2%, 42.9% and 2.9% among controls respectively.	Arginine	19-22	X-ray repair cross complementing 1	Homo sapiens	61-66
15555397-6	2004	The frequencies of Arg/Arg, Arg/Gln and Gln/Gln genotypes at XRCC1 Arg399Gln site were 46.7%, 41.9% and 11.4% among cases, while 54.2%, 42.9% and 2.9% among controls respectively.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	61-66
15555397-6	2004	The frequencies of Arg/Arg, Arg/Gln and Gln/Gln genotypes at XRCC1 Arg399Gln site were 46.7%, 41.9% and 11.4% among cases, while 54.2%, 42.9% and 2.9% among controls respectively.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	61-66
15247412-5	2004	Isolated Ncb5or-/- islets have markedly impaired glucose- or arginine-stimulated insulin secretion.	Arginine	61-69	cytochrome b5 reductase 4	Mus musculus	9-15
15196988-7	2004	In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --&gt; Val and His(372) --&gt; Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein).	Arginine	93-96	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	45-52
15196988-7	2004	In contrast, the catalytic efficiency of the CYP2A13 Ala(117) --&gt; Val and His(372) --&gt; Arg mutants was greatly increased (2.65 and 2.60 versus 0.31 for wild-type CYP2A13 protein).	Arginine	93-96	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	168-175
15111623-6	2004	Mutation of each of two clusters encompassing the residues Lys(89)-Arg(90)-Lys(91) and Lys(125)-Lys(125) significantly decreased the signal transduction of the respective MD-2 mutants either upon co-expression with TLR4 or upon addition as soluble protein into the supernatant of cells overexpressing TLR4.	Arginine	67-70	lymphocyte antigen 96	Homo sapiens	171-175
15111623-8	2004	In contrast, mutation of another basic cluster composed of Arg(69)-Lys(72), which according to the model lies further apart from the hydrophobic pocket only weakly decreased MD-2 activity.	Arginine	59-62	lymphocyte antigen 96	Homo sapiens	174-178
15180924-7	2004	Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport.	Arginine	162-170	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	48-52
15180924-7	2004	Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport.	Arginine	162-170	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	87-91
15291406-10	2004	CONCLUSIONS: One percent ARG supplementation of TPN does not improve GALT cell number or mucosal IgA level but benefits to increase CD4+ cell percentages in GALT.	Arginine	25-28	CD4 antigen	Mus musculus	132-135
15210948-7	2004	In addition, a haplotype coding for substitutions of two highly conserved arginine residues (Arg200Trp and Arg324Gly) in FRZB was a strong risk factor for primary hip OA, with an odds ratio of 4.1 (P = 0.004).	Arginine	74-82	frizzled related protein	Homo sapiens	121-125
15210950-0	2004	Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer.	Arginine	33-41	ATPase	Escherichia coli	55-61
15210950-0	2004	Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer.	Arginine	33-41	ATPase	Escherichia coli	101-107
15210950-3	2004	Studies on the oligomeric AAA(+) class ATPases suggest that a conserved arginine residue is located in close proximity to the ATPase site of the adjacent subunit and plays an essential role during ATP hydrolysis.	Arginine	72-80	ATPase	Escherichia coli	39-45
15210950-4	2004	This study presents direct evidence that Arg-174 of RuvB allosterically stimulates the ATPase of the adjacent subunit in a RuvB hexamer.	Arginine	41-44	ATPase	Escherichia coli	87-93
15210956-1	2004	In metazoans, multiple RNA-binding proteins, including the shuttling serine/arginine-rich (SR)-splicing factors, function as adapters for mRNA nuclear export by interacting with the export receptor TAP/nuclear export factor 1 (NXF1).	Arginine	76-84	nuclear RNA export factor 1	Homo sapiens	198-225
15210956-1	2004	In metazoans, multiple RNA-binding proteins, including the shuttling serine/arginine-rich (SR)-splicing factors, function as adapters for mRNA nuclear export by interacting with the export receptor TAP/nuclear export factor 1 (NXF1).	Arginine	76-84	nuclear RNA export factor 1	Homo sapiens	227-231
15033987-8	2004	Therefore, these results suggest that the N-terminal regions of FKBP12 (Gln-3 and Arg-18) and Met-49 are essential and unique for binding of FKBP12 to RyR1 in skeletal muscle.	Arginine	82-85	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	64-70
15033987-8	2004	Therefore, these results suggest that the N-terminal regions of FKBP12 (Gln-3 and Arg-18) and Met-49 are essential and unique for binding of FKBP12 to RyR1 in skeletal muscle.	Arginine	82-85	peptidyl-prolyl cis-trans isomerase FKBP1A	Oryctolagus cuniculus	141-147
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	87-90	keratin 1	Rattus norvegicus	60-63
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Rattus norvegicus	60-63
15040788-2	2004	Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds.	Arginine	91-94	keratin 1	Rattus norvegicus	60-63
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Arginine	79-82	prepronociceptin	Mus musculus	34-39
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Arginine	79-82	proprotein convertase subtilisin/kexin type 1	Mus musculus	190-213
15158481-6	2004	Insertion of a portion of the NST-N/OFQ precursor (Glu-Gln-Lys-Gln-Leu-Gln-Lys-Arg-Phe-Gly-Gly-Phe-Tyr-Gly) in Vluc-EYFP makes the fusion protein cleavable at Lys-Arg in NG108-15 cells, and proprotein convertase 1 enhances this digestion.	Arginine	163-166	prepronociceptin	Mus musculus	34-39
15170345-11	2004	Our results demonstrate that residues within and proximal to the C terminus of the Arg-14 loop are important modulators of ApB affinity for Na(V) channels, indicating that the loop and channel site 3 are likely in close contact.	Arginine	83-86	arginyl aminopeptidase	Homo sapiens	123-126
15175298-1	2004	The arginine regulatory protein of Pseudomonas aeruginosa, ArgR, is essential for induction of operons that encode enzymes of the arginine succinyltransferase (AST) pathway, which is the primary route for arginine utilization by this organism under aerobic conditions.	Arginine	4-12	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	59-63
15175298-4	2004	Exogenous arginine repressed the specific activities of glutamate synthase (GltBD) and anabolic NADP-dependent GDH (GdhA) in cell extracts of strain PAO1, and this repression was abolished in an argR mutant.	Arginine	10-18	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	195-199
15175298-6	2004	Measurements of beta-galactosidase expression from gltB::lacZ and gdhA::lacZ translational fusions confirmed the role of ArgR in mediating arginine repression.	Arginine	139-147	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	121-125
15175299-2	2004	We performed transcriptome analyses to identify genes controlled by the arginine regulatory protein ArgR and to better understand arginine metabolic pathways of P. aeruginosa.	Arginine	72-80	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	100-104
15175299-3	2004	We compared gene expression in wild-type strain PAO1 with that in argR mutant strain PAO501 grown in glutamate minimal medium in the presence and absence of arginine.	Arginine	157-165	transcriptional regulator ArgR	Pseudomonas aeruginosa PAO1	66-70
15140540-4	2004	In the present study, we established a convenient and reliable genotyping method for the MGMT codon 178 polymorphism, a Lys (AAG) to Arg (AGG) substitution, using restriction fragment length polymorphism (RFLP), and studied differences in the distribution of this polymorphism in 92 Caucasian lung cancer patients and 85 controls.	Arginine	133-136	O-6-methylguanine-DNA methyltransferase	Homo sapiens	89-93
15140540-4	2004	In the present study, we established a convenient and reliable genotyping method for the MGMT codon 178 polymorphism, a Lys (AAG) to Arg (AGG) substitution, using restriction fragment length polymorphism (RFLP), and studied differences in the distribution of this polymorphism in 92 Caucasian lung cancer patients and 85 controls.	Arginine	133-136	N-methylpurine DNA glycosylase	Homo sapiens	125-128
15194051-11	2004	We conclude that the arginine 22 amino acid residue of IP-10 is essential for both CXCR3 binding and angiostasis.	Arginine	21-29	C-X-C motif chemokine ligand 10	Homo sapiens	55-60
15192815-9	2004	A mutation of CGC--&gt;GGC was found at codon 617 in one ABCD1 allele of the third patient"s mother, leading to the glycine for arginine substitution.	Arginine	128-136	gamma-glutamylcyclotransferase	Homo sapiens	23-26
15149729-8	2004	In conclusion, our results provide for the first time evidence that functional abnormalities of type 2 experimental diabetes, such as the insulin hyper-responsiveness to arginine, could be due to an impairment of nNOS expression and/or activity in beta-cells.	Arginine	170-178	nitric oxide synthase 1	Rattus norvegicus	213-217
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Arginine	31-34	agouti related neuropeptide	Homo sapiens	71-76
15084118-13	2004	Furthermore, when the His-DPhe-Arg-Trp sequence is used to replace the hAGRP Arg-Phe-Phe residues in the "mini"-AGRP (hAGRP87-120, C105A) template, a potent nanomolar agonist resulted at the mMC1R and MC3-5Rs.	Arginine	77-80	agouti related neuropeptide	Homo sapiens	71-76
14705965-7	2004	Amino acid analysis of the methylated arginine residues confirmed that both DART1 and DART4 catalyse the formation of asymmetrical dimethylated arginine residues and they are type I arginine methyltransferases.	Arginine	38-46	Arginine methyltransferase 4	Drosophila melanogaster	86-91
14705965-7	2004	Amino acid analysis of the methylated arginine residues confirmed that both DART1 and DART4 catalyse the formation of asymmetrical dimethylated arginine residues and they are type I arginine methyltransferases.	Arginine	144-152	Arginine methyltransferase 4	Drosophila melanogaster	86-91
15016745-6	2004	Arginine and an NO donor activated focal adhesion kinase (a tyrosine kinase which localises to cell matrix contacts and mediates beta1 integrin signalling) after wounding.	Arginine	0-8	integrin subunit beta 1	Homo sapiens	129-143
15010853-4	2004	l-Arginine and l-Leucine induced activation of p70 S6 kinase and phosphorylation of 4E-BP1 in a rapamycin-sensitive manner, which suggested the involvement of mTOR signaling pathway in these effects.	Arginine	0-10	mechanistic target of rapamycin kinase	Rattus norvegicus	159-163
15010853-7	2004	In conclusion, l-Arginine regulates p70 S6 kinase activity and phosphorylation of 4E-BP1 through mTOR signaling pathway, which involves system y(+), cationic amino acid transporters.	Arginine	15-25	mechanistic target of rapamycin kinase	Rattus norvegicus	97-101
14707146-4	2004	Substitutions in and around this binding site and surface plasmon resonance analysis of heparin binding affinity identified two arginine residues of lymphotactin as critical for glycosaminoglycan binding.	Arginine	128-136	X-C motif chemokine ligand 1	Homo sapiens	149-161
14707146-5	2004	Both arginine mutant proteins and the combined double mutant had dramatically diminished in vivo activity in a leukocyte recruitment assay, suggesting that the lymphotactin-glycosaminoglycan interactions detected in vitro are important for the function of this chemokine.	Arginine	5-13	X-C motif chemokine ligand 1	Homo sapiens	160-172
14718525-0	2004	Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.	Arginine	25-33	TSC complex subunit 2	Homo sapiens	10-14
14982563-2	2004	Type-2 cationic amino acid transporter (CAT-2) mediation of trans-membrane L-arginine (L-Arg) transportation has been identified as one of the crucial regulatory mechanisms involved in the formation of NO by iNOS.	Arginine	75-85	solute carrier family 7 member 2	Rattus norvegicus	40-45
14993789-3	2004	As expected, hC3a containing high levels of Arg- and Lys-residues stimulated approx.	Arginine	44-47	complement C3	Homo sapiens	13-17
14993293-2	2004	Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl.	Arginine	38-41	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	254-259
14993293-7	2004	Reintroduction of c-Abl into Arg-Abl double-null fibroblasts rescues the ability of PLC-gamma1 to increase PDGF-mediated chemotaxis, while reexpression of Arg fails to rescue the chemotaxis defect.	Arginine	29-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	18-23
14676199-3	2004	The protein is similar to the other two serine/arginine (SR)-type proteins in yeast, Gbp2 and Npl3.	Arginine	47-55	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	94-98
14561219-4	2004	In the present study, we have functionally characterized the cystinuria-specific R365W (Arg(365)--&gt;Trp) mutation of human rBAT, which in addition to a trafficking defect, alters functional properties of the b(0,+) transporter.	Arginine	88-91	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	125-129
14561219-5	2004	In oocytes, where human rBAT interacts with the endogenous b(0,+)AT subunit to form an active transporter, the rBAT(R365W) mutation caused a defect of arginine efflux without altering arginine influx or apparent affinities for intracellular or extracellular arginine.	Arginine	151-159	solute carrier family 7 member 9	Homo sapiens	59-67
14561219-5	2004	In oocytes, where human rBAT interacts with the endogenous b(0,+)AT subunit to form an active transporter, the rBAT(R365W) mutation caused a defect of arginine efflux without altering arginine influx or apparent affinities for intracellular or extracellular arginine.	Arginine	151-159	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	111-115
14561219-7	2004	In HeLa cells, functional expression of rBAT(R365W)/b(0,+)AT was observed only at the permissive temperature of 33 degrees C. Under these conditions, the mutated transporter showed 50% reduction of arginine influx and a similar decreased accumulation of dibasic amino acids.	Arginine	198-206	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	40-44
14561219-7	2004	In HeLa cells, functional expression of rBAT(R365W)/b(0,+)AT was observed only at the permissive temperature of 33 degrees C. Under these conditions, the mutated transporter showed 50% reduction of arginine influx and a similar decreased accumulation of dibasic amino acids.	Arginine	198-206	solute carrier family 7 member 9	Homo sapiens	52-60
14561219-8	2004	Efflux of arginine through the rBAT(R365W)/b(0,+)AT holotransporter was completely abolished.	Arginine	10-18	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	31-35
14561219-8	2004	Efflux of arginine through the rBAT(R365W)/b(0,+)AT holotransporter was completely abolished.	Arginine	10-18	solute carrier family 7 member 9	Homo sapiens	43-51
14561219-9	2004	This supports a two-translocation-pathway model for antiporter b(0,+), in which the efflux pathway in the rBAT(R365W)/b(0,+)AT holotransporter is defective for arginine translocation or dissociation.	Arginine	160-168	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	106-110
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	ets variant 6	Mus musculus	0-3
15005341-4	2004	TEL/ARG was heavily phosphorylated on tyrosine residues and was also found to rapidly induce tyrosine phosphorylation of multiple cellular proteins, including rasGAP, CBL, STAT5, PI3K, SHP2, Dok, and SHC.	Arginine	4-7	src homology 2 domain-containing transforming protein C1	Mus musculus	200-203
15005341-7	2004	At least in Ba/F3 cells, although the growth rate was much lower compared to that with IL-3, TEL/ARG appeared to induce some cell proliferation as an immediate consequence.	Arginine	97-100	ets variant 6	Mus musculus	93-96
14962794-8	2004	Arginine/glycine (RG)-rich domains in components of the SMN complex interact with Sm, like-Sm (LSm), fibrillarin, RNA helicase A (Gu), and coilin proteins, all of which are antigen targets in a variety of diseases.	Arginine	0-8	fibrillarin	Homo sapiens	101-112
14687935-2	2004	CPN cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM).	Arginine	29-38	carboxypeptidase N subunit 1	Homo sapiens	0-3
14687935-4	2004	CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine.	Arginine	83-91	carboxypeptidase N subunit 1	Homo sapiens	0-3
15311993-3	2004	The relation between two arginine metabolic pathways governed by arginine decarboxylase and nitric oxide synthase was investigated.	Arginine	25-33	antizyme inhibitor 2	Rattus norvegicus	65-87
14688526-1	2003	BACKGROUND: A single nucleotide polymorphism in the tumor necrosis factor type II receptor (TNFRII) gene, codon 196, results in the substitution of arginine (R allele) for methionine (M allele).	Arginine	148-156	TNF receptor superfamily member 1B	Homo sapiens	52-90
14688526-1	2003	BACKGROUND: A single nucleotide polymorphism in the tumor necrosis factor type II receptor (TNFRII) gene, codon 196, results in the substitution of arginine (R allele) for methionine (M allele).	Arginine	148-156	TNF receptor superfamily member 1B	Homo sapiens	92-98
14660799-0	2003	A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.	Arginine	19-27	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	68-72
14660799-4	2003	We report that this altered vacuolar pH in btn1-delta strains underlies a lack of arginine transport into the vacuole, which results in a depletion of endogenous vacuolar arginine levels.	Arginine	82-90	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	43-47
14660799-4	2003	We report that this altered vacuolar pH in btn1-delta strains underlies a lack of arginine transport into the vacuole, which results in a depletion of endogenous vacuolar arginine levels.	Arginine	171-179	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	43-47
14660799-5	2003	This arginine transport defect in btn1-delta is complemented by expression of either BTN1 or the human CLN3 gene and strongly suggests a function for transport of, or regulation of the transport of, basic amino acids into the vacuole or lysosome for yeast Btn1p, and human CLN3 protein, respectively.	Arginine	5-13	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	85-89
14660799-5	2003	This arginine transport defect in btn1-delta is complemented by expression of either BTN1 or the human CLN3 gene and strongly suggests a function for transport of, or regulation of the transport of, basic amino acids into the vacuole or lysosome for yeast Btn1p, and human CLN3 protein, respectively.	Arginine	5-13	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	103-107
14660799-5	2003	This arginine transport defect in btn1-delta is complemented by expression of either BTN1 or the human CLN3 gene and strongly suggests a function for transport of, or regulation of the transport of, basic amino acids into the vacuole or lysosome for yeast Btn1p, and human CLN3 protein, respectively.	Arginine	5-13	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	273-277
14693738-2	2003	A common polymorphism (Arg--&gt;Gln) at codon 399 of the XRCC1 gene has been previously linked to functional changes of the gene product and risk of cancers.	Arginine	23-26	X-ray repair cross complementing 1	Homo sapiens	57-62
14709845-7	2003	By PCR direct sequencing, homozygous Trp (8) Arg and Ile (15) Thr mutations in exon 2 of LH beta were detected.	Arginine	45-48	luteinizing hormone subunit beta	Homo sapiens	89-96
14578391-7	2003	RESULTS: Pnn colocalized and copurified with serine-arginine (SR) proteins.	Arginine	52-60	pinin, desmosome associated protein	Homo sapiens	9-12
12896978-9	2003	The increased DNA affinity of CAR is mediated by the positively charged arginines 90 and 91 located in the carboxyl-terminal extension of the DNA-binding domain of the receptor.	Arginine	72-81	nuclear receptor subfamily 1 group I member 3	Homo sapiens	30-33
12853460-2	2003	We have previously shown that trichohyalin is sequentially subjected to post-synthetic modifications by peptidylarginine deaminases, which convert many of its arginines to citrullines, and by transglutaminases, which introduce intra- and interprotein chain cross-links.	Arginine	159-168	trichohyalin	Mus musculus	30-42
12893824-2	2003	The present studies demonstrate that c-Abl and Arg associate with glutathione peroxidase 1 (GPx1) and that this interaction is regulated by intracellular oxidant levels.	Arginine	47-50	glutathione peroxidase 1	Homo sapiens	66-90
12893824-2	2003	The present studies demonstrate that c-Abl and Arg associate with glutathione peroxidase 1 (GPx1) and that this interaction is regulated by intracellular oxidant levels.	Arginine	47-50	glutathione peroxidase 1	Homo sapiens	92-96
12893824-3	2003	The c-Abl and Arg SH3 domains bind directly to a proline-rich site in GPx1 at amino acids 132-145.	Arginine	14-17	glutathione peroxidase 1	Homo sapiens	70-74
12893824-4	2003	GPx1 also functions as a substrate for c-Abl- and Arg-mediated phosphorylation on Tyr-96.	Arginine	50-53	glutathione peroxidase 1	Homo sapiens	0-4
13680034-1	2003	OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function.	Arginine	34-42	adrenoceptor beta 2	Homo sapiens	201-227
13680034-1	2003	OBJECTIVE: It has been shown that arginine to glycine (Arg16Gly), glutamine to glutamic acid (Gln27Glu) and threonine to isoleucine (Thr164Ile) exchanges in codons 16, 27 and 164, respectively, of the beta 2-adrenergic receptor (B2AR) gene significantly alter receptor function.	Arginine	34-42	adrenoceptor beta 2	Homo sapiens	229-233
14557466-11	2003	In conclusion, these data suggest that the Arg(16) and Gln(27) variants of the beta(2)-adrenergic receptor gene contribute to metabolic syndrome susceptibility in men.	Arginine	43-46	adrenoceptor beta 2	Homo sapiens	79-106
14519756-2	2003	An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated with DNA damage.	Arginine	3-11	X-ray repair cross complementing 1	Homo sapiens	70-75
14519756-2	2003	An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated with DNA damage.	Arginine	13-16	X-ray repair cross complementing 1	Homo sapiens	70-75
14519756-7	2003	Various combinations of GSTM1 and GSTT1 genotypes differentially modified the association of XRCC1 with HCC (P(interaction) =.005); e.g., for individuals with the GSTT1-null/GSTM1-present genotype, the risk of HCC was greater for those with the Gln/Gln genotype (odds ratio = 8.07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype.	Arginine	347-350	X-ray repair cross complementing 1	Homo sapiens	93-98
14519756-7	2003	Various combinations of GSTM1 and GSTT1 genotypes differentially modified the association of XRCC1 with HCC (P(interaction) =.005); e.g., for individuals with the GSTT1-null/GSTM1-present genotype, the risk of HCC was greater for those with the Gln/Gln genotype (odds ratio = 8.07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype.	Arginine	351-354	X-ray repair cross complementing 1	Homo sapiens	93-98
12869544-4	2003	Moreover, the structural data suggested that arginine 130 (Arg130) of Arabidopsis Toc33 may function as a GTPase-activating "arginine-finger" at the other monomer in the Toc33 dimer.	Arginine	45-53	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	82-87
12869544-4	2003	Moreover, the structural data suggested that arginine 130 (Arg130) of Arabidopsis Toc33 may function as a GTPase-activating "arginine-finger" at the other monomer in the Toc33 dimer.	Arginine	45-53	translocon at the outer envelope membrane of chloroplasts 33	Arabidopsis thaliana	170-175
12777400-1	2003	The Abl family of mammalian non-receptor tyrosine kinases includes c-Abl and Arg.	Arginine	77-80	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-7
12876328-8	2003	They also point to additional structural requirements for Hsp47 binding besides the known preference for third-position Arg residues and the triple-helical conformation.	Arginine	120-123	serpin family H member 1	Homo sapiens	58-63
12932899-5	2003	The addition of the amino acid residue Arg to the N-terminal enhances the opioid receptor affinity of Noc(1-13)NH(2) while retaining ORL1 receptor affinity at a moderate level.	Arginine	39-42	opioid receptor-like 1	Mus musculus	133-137
12775773-6	2003	Among the tyrosine kinases, c-Abl and its relative Arg are unique in binding directly to F-actin.	Arginine	51-54	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	28-33
14517588-5	2003	The mutation is expected to result in an arginine to tryptophan substitution (R162W) in the beginning region of the alpha-helical 1A domain of K9.	Arginine	41-49	keratin 9	Homo sapiens	143-145
12809490-3	2003	ALY has a conserved RNA binding domain (RBD) flanked by Gly-Arg rich N-terminal and C-terminal sequences.	Arginine	60-63	Aly/REF export factor	Homo sapiens	0-3
12746844-6	2003	RESULTS: A higher frequency of this variant genotype (LH-betaV: Arg(8)/Thr(15)) was observed in familial prostate cancer patients (18.6%) than in controls (13.7%), and after taking into account the correlation of the familial cases and adjusting for age and body mass index (BMI), there was a weak positive association between the variant LH-beta genotype, and risk of familial prostate cancer (OR = 1.29; 95% CI 0.96-1.75).	Arginine	64-67	luteinizing hormone subunit beta	Homo sapiens	54-61
12783933-9	2003	RESULTS: Activating mutations in NRAS codon 61, all of which were either CAA(Gln)-AAA(Lys) or CAA(Gln)-CGA(Arg) mutations, were found in 95% (20/21) of primary hereditary melanomas but in only 10% (1/10) of sporadic melanomas (P&lt;.001).	Arginine	107-110	NRAS proto-oncogene, GTPase	Homo sapiens	33-37
12623793-1	2003	Kininase I-type carboxypeptidases convert native kinin agonists for B(2) receptors into B(1) receptor agonists by specifically removing the COOH-terminal Arg residue.	Arginine	154-157	carboxypeptidase N subunit 1	Homo sapiens	0-10
12787142-4	2003	We hypothesized that the keratinocyte-derived member of this Glu-Leu-Arg-negative CXC family, interferon gamma inducible protein 9 (IP-9) CXCL11 (also known as I-TAC, beta-R1, and H-174) signals to the dermal compartment to synchronize the re-epithelialization process.	Arginine	69-72	C-X-C motif chemokine ligand 11	Homo sapiens	94-130
12787142-4	2003	We hypothesized that the keratinocyte-derived member of this Glu-Leu-Arg-negative CXC family, interferon gamma inducible protein 9 (IP-9) CXCL11 (also known as I-TAC, beta-R1, and H-174) signals to the dermal compartment to synchronize the re-epithelialization process.	Arginine	69-72	C-X-C motif chemokine ligand 11	Homo sapiens	132-136
12787142-4	2003	We hypothesized that the keratinocyte-derived member of this Glu-Leu-Arg-negative CXC family, interferon gamma inducible protein 9 (IP-9) CXCL11 (also known as I-TAC, beta-R1, and H-174) signals to the dermal compartment to synchronize the re-epithelialization process.	Arginine	69-72	C-X-C motif chemokine ligand 11	Homo sapiens	138-144
12787142-4	2003	We hypothesized that the keratinocyte-derived member of this Glu-Leu-Arg-negative CXC family, interferon gamma inducible protein 9 (IP-9) CXCL11 (also known as I-TAC, beta-R1, and H-174) signals to the dermal compartment to synchronize the re-epithelialization process.	Arginine	69-72	C-X-C motif chemokine ligand 11	Homo sapiens	160-165
12820970-5	2003	Mutating the conserved arginine in helix 2 reduced LRH-1 receptor activity and coregulator recruitment, consistent with the partial loss-of-function phenotype exhibited by an analogous SF-1 human mutant.	Arginine	23-31	splicing factor 1	Homo sapiens	185-189
12748290-4	2003	We show here that these two pathways mediate phosphorylation at distinct sites in Abl and Arg and have additive effects on Abl and Arg kinase activation.	Arginine	90-93	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	123-126
12713848-1	2003	A peptidomimetic template, consisting of a hydrophobic scaffold, a dansyl fluorophore, and an Arg-His recognition strand, was tested as a simple mimic of zinc finger 2 of the Zif268 protein.	Arginine	94-97	Yip1 domain family member 2	Homo sapiens	159-167
12737940-0	2003	Molecular characterization of G6PD Insuli--a novel 989 CGC --&gt; CAC (330 Arg --&gt; His) mutation in the Indian population.	Arginine	75-78	glucose-6-phosphate dehydrogenase	Homo sapiens	30-34
12699619-4	2003	RESULTS: By employing a tetrameric affinity construct of the C terminus of the K(ATP) channel alpha subunit, Kir6.2, we found that 14-3-3 isoforms epsilon and zeta specifically recognize the arginine-based ER localization signal present in this cytosolic tail.	Arginine	191-199	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	79-115
12699619-7	2003	Comparison of monomeric CD4, dimeric CD8, and artificially tetramerized CD4 fusions correlates the copy number of the tail containing the arginine-based signal with 14-3-3 binding, resulting in the surface expression of the membrane protein.	Arginine	138-146	CD8a molecule	Homo sapiens	37-40
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	0-3	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	0-3	ATP binding cassette subfamily C member 2	Homo sapiens	122-126
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	44-47	ATP binding cassette subfamily C member 2	Homo sapiens	19-23
12721111-10	2003	Arg(1210) in human MRP2 that corresponds to Arg(1202) in human MRP1 has an important role in the transporting activity of MRP2.	Arginine	44-47	ATP binding cassette subfamily C member 2	Homo sapiens	122-126
12672064-7	2003	Bovine KIR2DS1 and KIR3DS1 lack ITIM but have an arginine-containing motif in their transmembrane domain, similar to primate KIR2DL4.	Arginine	49-57	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	Bos taurus	7-14
12672064-7	2003	Bovine KIR2DS1 and KIR3DS1 lack ITIM but have an arginine-containing motif in their transmembrane domain, similar to primate KIR2DL4.	Arginine	49-57	killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1	Bos taurus	19-26
12551939-6	2003	Both the N-terminal region, with the LXXLL motif, and the C-terminal region, with a serine/arginine-rich domain (RS domain), in PGC-1 alpha were required for full activation of CAR.	Arginine	91-99	nuclear receptor subfamily 1 group I member 3	Homo sapiens	177-180
12590926-2	2003	In this study we have employed mutagenesis to investigate how residues Y357 and R365 which interact primarily with the substrate Arg and (6R)-5,6,7,8-tetrahydro-L-biopterin (H(4)B) modulate these two steps of the NOS reaction.	Arginine	129-132	H4 clustered histone 4	Homo sapiens	174-179
12590926-7	2003	When Arg was removed from buffer, R365L instantly became a low-spin state (Soret peak at 418 nm) with the resultant loss of H(4)B and instability of the heme-CO complex.	Arginine	5-8	H4 clustered histone 4	Homo sapiens	124-129
12579527-5	2003	The results indicate that arginine, citrulline and ornithine supplementation increased the flux of substrate through the reaction catalysed by glutamine synthetase, leading to increased glutamine production after an exhaustive bout of exercise, and of the mechanism involved in ammonia buffering.	Arginine	26-34	glutamate-ammonia ligase	Rattus norvegicus	143-163
12623979-1	2003	L-Arginine inhibits thick ascending limb (THAL) NaCl absorption by activating endothelial NO synthase (eNOS) and increasing NO production.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	103-107
12623979-3	2003	We hypothesized that a high-salt diet enhances the inhibitory action of L-arginine on NaCl absorption by THALs because of increased eNOS expression and NO production.	Arginine	72-82	nitric oxide synthase 3	Rattus norvegicus	132-136
12623979-12	2003	L-Arginine-stimulated NO production was not enhanced by a HS diet, despite increased eNOS protein.	Arginine	0-10	nitric oxide synthase 3	Rattus norvegicus	85-89
12626632-2	2003	The vertebrate Abl family kinases, Abl and Arg, are expressed in the adult mouse brain, where they may regulate actin cytoskeletal dynamics in mature neurons.	Arginine	43-46	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	15-18
12667464-2	2003	We demonstrate that at least three shuttling SR (serine/arginine-rich) proteins interact with the same domain of TAP/NXF1 that binds REFs.	Arginine	56-64	nuclear RNA export factor 1	Homo sapiens	113-116
12667464-2	2003	We demonstrate that at least three shuttling SR (serine/arginine-rich) proteins interact with the same domain of TAP/NXF1 that binds REFs.	Arginine	56-64	nuclear RNA export factor 1	Homo sapiens	117-121
12590583-1	2003	How 6R-tetrahydrobiopterin (H(4)B) participates in Arg hydroxylation as catalyzed by the nitric oxide synthases (NOSs) is a topic of current interest.	Arginine	51-54	H4 clustered histone 4	Homo sapiens	28-33
12590583-2	2003	Previous work with the oxygenase domain of inducible NOS (iNOSoxy) demonstrated that H(4)B radical formation is kinetically coupled to disappearance of an initial heme-dioxy intermediate and to Arg hydroxylation in a single turnover reaction run at 10 degrees C [Wei, C.-C., Wang, Z.-Q., Wang, Q., Meade, A. L., Hemann, C., Hille, R., and Stuehr, D. J.	Arginine	194-197	H4 clustered histone 4	Homo sapiens	85-90
12590583-7	2003	In the presence of Arg, the heme-dioxy intermediate in 5-methyl-H(4)B-bound iNOSoxy reacted at a rate of 35 s(-)(1), which is 3-fold faster than with H(4)B.	Arginine	19-22	H4 clustered histone 4	Homo sapiens	64-69
12590583-7	2003	In the presence of Arg, the heme-dioxy intermediate in 5-methyl-H(4)B-bound iNOSoxy reacted at a rate of 35 s(-)(1), which is 3-fold faster than with H(4)B.	Arginine	19-22	H4 clustered histone 4	Homo sapiens	150-155
12480933-7	2003	Study of the Mcm3/7p ATPase shows that an essential arginine in Mcm3p is required for hydrolysis of the ATP bound to Mcm7p.	Arginine	52-60	ATPase	Escherichia coli	21-27
12525645-5	2003	Activation of cells lacking ASF/SF2 through anti-immunoglobulin M-B-cell receptor cross-linking rescued viral RNA expression and splicing at the proximal 3" splice site and enhanced Akt phosphorylation and expression of the phosphorylated serine/arginine-rich (SR) proteins SRp30s (especially SC35) and SRp40.	Arginine	246-254	serine and arginine rich splicing factor 1	Homo sapiens	28-35
12535064-6	2003	In additional work, we found that lactoferrin cleaves IgA1 protease at an arginine-rich region defined by amino acids 1379-1386 (RRSRRSVR) and digests Hap at an arginine-rich sequence between amino acids 1016 and 1023 (VRSRRAAR).	Arginine	74-82	immunoglobulin heavy constant alpha 1	Homo sapiens	54-58
12535064-6	2003	In additional work, we found that lactoferrin cleaves IgA1 protease at an arginine-rich region defined by amino acids 1379-1386 (RRSRRSVR) and digests Hap at an arginine-rich sequence between amino acids 1016 and 1023 (VRSRRAAR).	Arginine	161-169	immunoglobulin heavy constant alpha 1	Homo sapiens	54-58
12527768-8	2003	Of particular interest, ECP/RNase 3"s cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine.	Arginine	84-92	ribonuclease A family member 3	Homo sapiens	24-27
12527768-8	2003	Of particular interest, ECP/RNase 3"s cationicity is based on an (over)abundance of arginine residues, whereas RNase 7 includes an excess of lysine.	Arginine	84-92	ribonuclease A family member 3	Homo sapiens	28-35
12417581-4	2003	Expression of b(0,+)AT-rBAT alone led to a net reabsorption of l-Arg (given together with l-Leu).	Arginine	63-68	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	23-27
12467633-2	2003	Further SAR studies resulted in the discovery of Penta-5-BrAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and Penta-5-Me(2)NAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) which are potent hMC4R agonists and are inactive in hMC1R, hMC3R and hMC5R agonist assays.	Arginine	74-77	melanocortin 4 receptor	Homo sapiens	180-185
12467633-2	2003	Further SAR studies resulted in the discovery of Penta-5-BrAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) and Penta-5-Me(2)NAtc(6)-DPhe(7)-Arg(8)-Trp(9)-Gly(10)-NH(2) which are potent hMC4R agonists and are inactive in hMC1R, hMC3R and hMC5R agonist assays.	Arginine	74-77	melanocortin 5 receptor	Homo sapiens	232-237
12474143-6	2003	Mutation analysis of COX15 in the patient identified a missense mutation (C700T) on one allele, changing a conserved arginine to tryptophan (R217W), and a splice-site mutation in intron 3 on the other allele (C447-3G), resulting in a deletion of exon 4.	Arginine	117-125	cytochrome c oxidase assembly homolog COX15	Homo sapiens	21-26
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	14-22	solute carrier family 7 member 1	Homo sapiens	107-140
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	14-22	solute carrier family 7 member 1	Homo sapiens	142-146
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	189-197	solute carrier family 7 member 1	Homo sapiens	107-140
12507771-4	2003	The increased arginine uptake in APOE4 Tg microglia is associated with an increased expression of mRNA for cationic amino acid transporter-1 (Cat1), a constuitively expressed member of the arginine selective transport system (the y+ transport system) found in most cells.	Arginine	189-197	solute carrier family 7 member 1	Homo sapiens	142-146
12732238-4	2003	The soluble RGD-containing peptide glycine-arginine-glycine-aspartate-serine-proline (GRGDSP) increased neurotrophin mRNA levels in transcript- and subfield-specific fashions.	Arginine	43-51	brain derived neurotrophic factor	Homo sapiens	104-116
12506130-5	2003	The recent colocalization of the cationic amino acid transporter CAT-1 (system y(+)), nitric oxide synthase (eNOS), and caveolin-1 in endothelial plasmalemmal caveolae provides a novel mechanism for the regulation of NO production by L-arginine delivery and circulating hormones such insulin and 17beta-estradiol.	Arginine	234-244	solute carrier family 7 member 1	Homo sapiens	65-70
14526489-8	2003	The homozygous glycine-16 (Arg--&gt;Gly) variant of the beta 2-adrenoceptor is known to predispose to agonist-induced down-regulation and desensitization, and may play a role in the pathogenesis of asthma severity.	Arginine	27-30	adrenoceptor beta 2	Homo sapiens	56-75
12388547-10	2002	These findings show that the endocannabinoid system, through the modulation of the l-arginine/NO pathway, reduces HIV-1 Tat-induced cytotoxicity, and is itself regulated by HIV-1 Tat.	Arginine	83-93	Tat	Human immunodeficiency virus 1	120-123
12388547-10	2002	These findings show that the endocannabinoid system, through the modulation of the l-arginine/NO pathway, reduces HIV-1 Tat-induced cytotoxicity, and is itself regulated by HIV-1 Tat.	Arginine	83-93	Tat	Human immunodeficiency virus 1	179-182
12565793-0	2002	Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis.	Arginine	76-86	fibroblast growth factor 7	Rattus norvegicus	29-61
12565793-5	2002	In the present study, we attempted to immunohistochemically determine the localization of FGF-7 and FGF-10 in pancreatic tissues of an L-arginine-induced rat pancreatitis model.	Arginine	135-145	fibroblast growth factor 7	Rattus norvegicus	90-95
12565793-9	2002	In the pancreatic tissues of rats with L-arginine-induced pancreatitis, FGF-7 was localized in alpha cells, whereas FGF-10 was expressed in vascular smooth muscle cells (VSMCs).	Arginine	39-49	fibroblast growth factor 7	Rattus norvegicus	72-77
12442007-8	2002	RESULTS: The frequency of the Arg/Arg genotype of the ADRB2 gene and the TT genotype of the IL-4 gene were significantly higher in patients with interstitial cystitis than in controls.	Arginine	30-33	adrenoceptor beta 2	Homo sapiens	54-59
12442007-8	2002	RESULTS: The frequency of the Arg/Arg genotype of the ADRB2 gene and the TT genotype of the IL-4 gene were significantly higher in patients with interstitial cystitis than in controls.	Arginine	34-37	adrenoceptor beta 2	Homo sapiens	54-59
12446172-4	2002	Using macrophages from Cat2-deficient mice, we previously determined that arginine uptake via CAT2 is absolutely required for sustained NO production.	Arginine	74-82	dominant cataract 2	Mus musculus	23-27
12446172-4	2002	Using macrophages from Cat2-deficient mice, we previously determined that arginine uptake via CAT2 is absolutely required for sustained NO production.	Arginine	74-82	dominant cataract 2	Mus musculus	94-98
12446172-7	2002	As expected, activated Cat2(-/-) fibroblasts had reduced system y(+)-mediated arginine uptake.	Arginine	78-86	dominant cataract 2	Mus musculus	23-27
12446172-11	2002	The data demonstrate that fibroblasts and macrophages have differential dependence on CAT2-mediated L-arginine transport for NO synthesis.	Arginine	100-110	dominant cataract 2	Mus musculus	86-90
12461395-6	2002	METHODS: Blood samples from 135 middle-aged men who had undergone magnetic resonance imaging (MRI) of the lumbar spine were analyzed for the presence of an arginine to tryptophan change in the COL9A3 gene (Trp3 allele).	Arginine	156-164	collagen type IX alpha 3 chain	Homo sapiens	193-199
12169693-1	2002	We identified a novel serine/arginine (SR)-rich-related protein as a binding partner of Clk4 mutant lacking kinase activity (Clk4 K189R) in the two-hybrid screen and designated it Clasp (Clk4-associating SR-related protein).	Arginine	29-37	CLK4-associating serine/arginine rich protein	Mus musculus	187-222
12507235-8	2002	RESULTS: Adherent cells on Ti plates, with and without GDP, were significantly reduced in serum-free conditions and the presence of RGDS (Arg-Gly-Asp-Ser) peptides.	Arginine	138-141	ral guanine nucleotide dissociation stimulator	Mus musculus	132-136
12414858-3	2002	We have previously shown that FGF-23 is cleaved between Arg(179) and Ser(180), and this processing abolished biological activity of FGF-23 to induce hypophosphatemia.	Arginine	56-59	fibroblast growth factor 23	Homo sapiens	30-36
12414858-3	2002	We have previously shown that FGF-23 is cleaved between Arg(179) and Ser(180), and this processing abolished biological activity of FGF-23 to induce hypophosphatemia.	Arginine	56-59	fibroblast growth factor 23	Homo sapiens	132-138
12388722-10	2002	The binding of ORF 73 to p32 is mediated by an amino-terminal arginine-rich domain, which contains two functionally distinct nuclear localization signals.	Arginine	62-70	CD8a molecule	Homo sapiens	25-28
12371970-3	2002	l-Arginine (l-Arg), the only precursor for NO, is transported into cells by cationic amino acid transporters, CAT-1 and CAT-2.	Arginine	0-10	solute carrier family 7 member 2	Rattus norvegicus	120-125
12371970-3	2002	l-Arginine (l-Arg), the only precursor for NO, is transported into cells by cationic amino acid transporters, CAT-1 and CAT-2.	Arginine	0-5	solute carrier family 7 member 2	Rattus norvegicus	120-125
12371970-14	2002	CONCLUSIONS: Ischemic ARF is associated with augmented tubular CAT-2 mRNA expression, which leads to enhanced l-Arg transport and increased NO production.	Arginine	110-115	solute carrier family 7 member 2	Rattus norvegicus	63-68
12163491-6	2002	The Arg(709) and Arg(1018) cleavages occurred at low thrombin concentrations and decreased the K(d) for FXa binding 5- and 3-fold, respectively.	Arginine	4-7	coagulation factor X	Homo sapiens	104-107
12163491-6	2002	The Arg(709) and Arg(1018) cleavages occurred at low thrombin concentrations and decreased the K(d) for FXa binding 5- and 3-fold, respectively.	Arginine	17-20	coagulation factor X	Homo sapiens	104-107
12163491-7	2002	The Arg(1545) cleavage, being less sensitive to thrombin, decreased the K(d) for FXa binding approximately 20-fold.	Arginine	4-7	coagulation factor X	Homo sapiens	81-84
12359751-6	2002	Arginine is synthesized from citrulline in two steps by argininosuccinate synthetase and argininosuccinate lyase.	Arginine	0-8	argininosuccinate lyase	Homo sapiens	89-112
12523648-0	2002	Arginine methylation of recombinant murine fibrillarin by protein arginine methyltransferase.	Arginine	0-8	fibrillarin	Homo sapiens	43-54
12362232-3	2002	It converts prothrombin to thrombin by cleaving both the peptide bonds Arg(274)-Thr(275) and Arg(323)-Ile(324), similar to mammalian factor Xa.	Arginine	71-74	coagulation factor X	Homo sapiens	133-142
12362232-3	2002	It converts prothrombin to thrombin by cleaving both the peptide bonds Arg(274)-Thr(275) and Arg(323)-Ile(324), similar to mammalian factor Xa.	Arginine	93-96	coagulation factor X	Homo sapiens	133-142
12234930-9	2002	Expressing the cystinuria-specific mutant A354T of b(o,+)AT in HeLa cells together with rBAT resulted in defective arginine uptake in whole cells, which was paralleled by the reconstituted b(o,+)AT activity.	Arginine	115-123	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	88-92
12105220-8	2002	Point mutations in Snl1p that disrupted the conserved residues Glu-112 and Arg-141, equivalent to Glu-212 and Arg-237 in Bag-1M, abolished the interaction with Hsp70 proteins.	Arginine	75-78	heat shock protein family A (Hsp70) member 4	Homo sapiens	160-165
12105220-8	2002	Point mutations in Snl1p that disrupted the conserved residues Glu-112 and Arg-141, equivalent to Glu-212 and Arg-237 in Bag-1M, abolished the interaction with Hsp70 proteins.	Arginine	110-113	heat shock protein family A (Hsp70) member 4	Homo sapiens	160-165
12000310-5	2002	Kallistatin (Arg(300)-Pro(319))-derived peptide (HC2) and one derived from antithrombin III helix D [(AT3D), corresponding to Ser(112)-Lys(139)], which are the heparin-binding sites in these serpins, showed significant affinity for 4500 Da heparin, for which K(d) values were 17 nM and 100 nM respectively.	Arginine	13-16	serpin family A member 4	Homo sapiens	0-11
12211444-2	2002	Sequence analysis of the total vitamin D receptor (VDR) cDNA from skin fibroblasts revealed a substitution of the unique tryptophan of the VDR by arginine at amino acid 286 (W286R).	Arginine	146-154	vitamin D receptor	Homo sapiens	31-49
12211444-2	2002	Sequence analysis of the total vitamin D receptor (VDR) cDNA from skin fibroblasts revealed a substitution of the unique tryptophan of the VDR by arginine at amino acid 286 (W286R).	Arginine	146-154	vitamin D receptor	Homo sapiens	51-54
12211444-2	2002	Sequence analysis of the total vitamin D receptor (VDR) cDNA from skin fibroblasts revealed a substitution of the unique tryptophan of the VDR by arginine at amino acid 286 (W286R).	Arginine	146-154	vitamin D receptor	Homo sapiens	139-142
12213855-8	2002	However, a missense point mutation was detected in the SDHB gene: c.725G--&gt;A in exon 7, which alters a conserved arginine at amino acid position 242 to a histidine (R242H).	Arginine	116-124	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	55-59
12065586-7	2002	The amino acid sequence of Gemin7 does not contain any recognizable motifs with the exception of several arginine and glycine repeats that are necessary for its interaction with SMN.	Arginine	105-113	gem nuclear organelle associated protein 7	Homo sapiens	27-33
12048205-2	2002	It involves the interaction between two oxygenase domains (NOSoxy) that each bind heme and (6R)-tetrahydrobiopterin (H4B) and catalyze NO synthesis from L-Arg.	Arginine	153-158	H4 clustered histone 4	Homo sapiens	117-120
12097318-7	2002	We also demonstrate that, like its mammalian homolog PRMT1, Rmt1 specifically dimethylates an arginine residue at position 3 of histone H4 N-terminal tail.	Arginine	94-102	protein arginine methyltransferase 1	Homo sapiens	53-58
12137915-1	2002	Agmatine is an endogenous amine derived from the decarboxylation of arginine by arginine decarboxylase (ADC), and metabolized to putrescine by agmatinase.	Arginine	68-76	antizyme inhibitor 2	Rattus norvegicus	80-102
12183419-2	2002	One genetic polymorphism (G--&gt;A, Arg--&gt;Gln at codon 399) occurs within a poly(ADP-ribose) polymerase binding region and within the central breast cancer susceptibility gene 1 product COOH terminus domain of XRCC1.	Arginine	36-39	X-ray repair cross complementing 1	Homo sapiens	213-218
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Arginine	82-85	X-ray repair cross complementing 1	Homo sapiens	64-69
12183419-11	2002	Analyses of combined genotypes suggested an interaction between XRCC1 (Gln/Gln or Arg/Gln) and GSTT1/GSTM1-null/null among women but not among men.	Arginine	82-85	glutathione S-transferase theta 1	Homo sapiens	95-100
12124811-5	2002	We found that individuals with Trp/Trp genotype at XRCC1 Arg194Trp site had a 2-fold increased risk of this disease compared to Arg/Arg genotype (adjusted OR = 1.98; 95% CI 1.26-3.12).	Arginine	57-60	X-ray repair cross complementing 1	Homo sapiens	51-56
12176364-0	2002	A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.	Arginine	16-19	lymphocyte cytosolic protein 2	Homo sapiens	103-109
12456008-9	2002	Collectively, these results indicate that altered levels of Btn2p can modulate arginine uptake through localization of the Can1p-arginine permease regulatory protein, Rsglp.	Arginine	79-87	arginine permease CAN1	Saccharomyces cerevisiae S288C	123-128
12134018-2	2002	We detected two kinases of 95 and 115 kDa in HuH-7 total cell lysates which interacted specifically with the HBV core protein and phosphorylated its arginine-rich C-terminal domain.	Arginine	149-157	MIR7-3 host gene	Homo sapiens	45-50
12072215-4	2002	At the optimum pH of 5.5, hydrolysis of Z-Phe-Arg-NHMec was three-fold greater than that of Z-Arg-Arg-NHMec suggesting that the proteolytic specificities of the ESP are more like those of papain or cathepsin L, rather than cathepsin B.	Arginine	46-49	cathepsin B	Homo sapiens	223-234
12102635-8	2002	However, the cDNA of platelet CKIIalpha has a different amino acid at position 236 (Arg --&gt; His), which is not found in the intronless gene.	Arginine	84-87	casein kinase 2 alpha 2	Homo sapiens	30-39
12123805-2	2002	To determine whether the RGD (Arg-Gly-Asp) motif of IGFBP-2 mediates cell surface binding in vivo, we mutated the RGD motif of IGFBP-2 into an RGE (Arg-Gly-Glu) sequence and produced transgenic mice (E mice) which express elevated amounts of mutated IGFBP-2.	Arginine	30-33	insulin-like growth factor binding protein 2	Mus musculus	52-59
12123805-2	2002	To determine whether the RGD (Arg-Gly-Asp) motif of IGFBP-2 mediates cell surface binding in vivo, we mutated the RGD motif of IGFBP-2 into an RGE (Arg-Gly-Glu) sequence and produced transgenic mice (E mice) which express elevated amounts of mutated IGFBP-2.	Arginine	148-151	insulin-like growth factor binding protein 2	Mus musculus	52-59
12105387-7	2002	Furthermore, FGF-23 was proteolytically processed between Arg(179) and Ser(180), and all mutations found in ADHR existed in this proteolytic consensus site.	Arginine	58-61	fibroblast growth factor 23	Mus musculus	13-19
12080468-6	2002	It is also shown that multiple signaling molecules, including PI3K, SHC, ras-GAP and CRK-L, are tyrosine phosphorylated in Ba/F3 cells that express ETV6/ARG.	Arginine	153-156	src homology 2 domain-containing transforming protein C1	Mus musculus	68-71
12056914-7	2002	Most of nNOS (65-80%) showed competition between Arg and imidazole.	Arginine	49-52	nitric oxide synthase 1	Rattus norvegicus	8-12
12056914-13	2002	We propose that this heterogeneous response of nNOS toward Arg and imidazole is underlying the apparently conflicting results reported in the literature.	Arginine	59-62	nitric oxide synthase 1	Rattus norvegicus	47-51
12116253-5	2002	This C to T transition is predicted to cause an arginine to cysteine amino acid change in a highly conserved region of the recognition helix of the homeodomain, which may reduce the stability of the interaction between the SHOX protein and its target DNA.	Arginine	48-56	short stature homeobox	Homo sapiens	223-227
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Arginine	81-84	coagulation factor X	Homo sapiens	0-9
11925440-1	2002	Factor Xa (FXa) hydrolyzes two peptide bonds in prothrombin having (Glu/Asp)-Gly-Arg-(Thr/Ile) for P(3)-P(2)-P(1)-P(1)" residues, but the exact preferences of its catalytic groove remain largely unknown.	Arginine	81-84	coagulation factor X	Homo sapiens	11-14
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Arginine	180-188	histone H2B	Saccharomyces cerevisiae S288C	17-28
12024015-9	2002	In one of these, histone H2B is the likely target for ubiquitination by Rad6, since a strain expressing histone H2B with the principal ubiquitination site converted from lysine to arginine shows a fivefold relief of repression.	Arginine	180-188	histone H2B	Saccharomyces cerevisiae S288C	104-115
12138697-9	2002	However, a heterozygous single base-pair transition (leucine to arginine) was detected in codon 527 of the TGFBI gene in 4 out of these 6 patients.	Arginine	64-72	transforming growth factor beta induced	Homo sapiens	107-112
12071709-3	2002	The PDE was found to be expressed in the form of inclusion bodies which could be refolded to an active enzyme in buffer containing high concentrations of arginine hydrochloride, ethylene glycol, and magnesium chloride at pH 8.5.	Arginine	154-176	aldehyde dehydrogenase 7 family member A1	Homo sapiens	4-7
11901152-5	2002	Among the 5 non-conserved residues within this segment, Arg-142 in human and Gln-142 in mouse ADA largely determined the capacity for stable binding to CD26 (Richard, E., Arredondo-Vega, F. X., Santisteban, I., Kelly, S. J., Patel, D. D., and Hershfield, M. S. (2000) J. Exp.	Arginine	56-59	adenosine deaminase	Homo sapiens	94-97
11901152-9	2002	In addition to Arg-142, we found that Glu-139 and Asp-143 of human ADA are also important for CD26 binding.	Arginine	15-18	adenosine deaminase	Homo sapiens	67-70
12007570-2	2002	C-terminally (Arg to Met) substituted analogs of the insect tachykinin-related peptide, Lom-TK I, displayed increased agonistic potencies in luminescent assays for human NK1 and NK2 receptors, whereas they showed reduced potencies in the STKR-assay.	Arginine	14-17	tachykinin receptor 2	Homo sapiens	178-181
12009947-1	2002	Three amino acids residues, Arg-Gly-Asp (RGD), in vitronectin and fibronectin show affinity for alpha(V)beta(3) integrins expressed in vascular endothelial cells.	Arginine	28-31	vitronectin	Homo sapiens	50-61
12010780-4	2002	Here we describe the in vitro and in vivo pharmacological profile of a novel NOP receptor ligand, [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101).	Arginine	107-110	prepronociceptin	Mus musculus	123-128
11961120-2	2002	Our results support the hypothesis that a salt bridge between the highly conserved arginine (R143(3.50)) of the E/DRY motif of helix 3 and a conserved glutamate (E289(6.30)) on helix 6 constrains the alpha1b-AR in the inactive state.	Arginine	83-91	adrenoceptor alpha 1B	Homo sapiens	200-210
11934586-1	2002	Anisylazoformylarginine (CH(3)OC(6)H(4)-N=N-CO-Arg-OH) is rapidly hydrolyzed at the acyl-arginine linkage by the zinc-enzyme porcine carboxypeptidase B.	Arginine	15-23	carboxypeptidase B1	Homo sapiens	133-151
11781318-1	2002	The cationic amino acid transporter, Cat-1, is a high affinity transporter of the essential amino acids, arginine and lysine.	Arginine	105-113	solute carrier family 7 member 1	Homo sapiens	37-42
11781318-3	2002	It is shown here that cat-1 gene expression is also induced by Glc limitation, which causes a 7-fold increase in cat-1 mRNA, a 30-fold induction of Cat-1 protein levels, and a 4-fold stimulation of arginine uptake.	Arginine	198-206	solute carrier family 7 member 1	Homo sapiens	22-27
11884718-3	2002	Here we report the crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence.	Arginine	138-141	integrin subunit alpha V	Homo sapiens	69-89
11911858-1	2002	Agmatine, decarboxylated from arginine by arginine decarboxylase, is particularly prominent in the hypothalamus.	Arginine	30-38	antizyme inhibitor 2	Rattus norvegicus	42-64
11985581-2	2002	The orf6 gene of the clavulanic acid biosynthetic gene cluster in S. clavuligerus encodes a protein that shows sequence homology to ornithine acetyltransferase (OAT), the fifth enzyme of the arginine biosynthetic pathway.	Arginine	191-199	hypothetical protein	Escherichia coli	4-8
12165288-7	2002	Furthermore, since those mRNA inductions by BK were enhanced by nitro-L-arginine-methyl ester (L-NAME) and attenuated by L-arginine (L-Arg), NO was speculated to negatively contribute to the expressions of TF and PAI-1.	Arginine	133-138	coagulation factor III, tissue factor	Rattus norvegicus	206-208
11829470-6	2002	Our model is consistent with previous experimental data and provides the first plausible structural basis of the effects of a common genetic polymorphism (Arg(64)--&gt;Gln) on NAT2 activity.	Arginine	155-158	N-acetyltransferase 2	Homo sapiens	176-180
11713257-2	2002	SRCs have been demonstrated to recruit CARM1 (coactivator-associated arginine methyltransferase-1), a member of the S-adenosyl-l-methionine-dependent PRMT1-5 (protein-arginine N-methyltransferase-1-5) family, which catalyzes the methylation of arginine residues.	Arginine	69-77	coactivator associated arginine methyltransferase 1	Homo sapiens	39-44
11713257-2	2002	SRCs have been demonstrated to recruit CARM1 (coactivator-associated arginine methyltransferase-1), a member of the S-adenosyl-l-methionine-dependent PRMT1-5 (protein-arginine N-methyltransferase-1-5) family, which catalyzes the methylation of arginine residues.	Arginine	69-77	protein arginine methyltransferase 1	Homo sapiens	150-157
11713257-2	2002	SRCs have been demonstrated to recruit CARM1 (coactivator-associated arginine methyltransferase-1), a member of the S-adenosyl-l-methionine-dependent PRMT1-5 (protein-arginine N-methyltransferase-1-5) family, which catalyzes the methylation of arginine residues.	Arginine	69-77	protein arginine methyltransferase 1	Homo sapiens	159-199
11713257-10	2002	This work clearly demonstrates that the arginine methyltransferase CARM1 potentiates myogenesis and supports the positive role of arginine methylation in mammalian differentiation.	Arginine	40-48	coactivator associated arginine methyltransferase 1	Homo sapiens	67-72
11846796-6	2002	It was shown that the binding of LBR fragments to chromatin was stimulated by phosphorylation in the arginine-serine repeat-containing region by a protein kinase(s) in a synthetic phase egg cytosol.	Arginine	101-109	lamin B receptor S homeolog	Xenopus laevis	33-36
11846796-8	2002	These results suggested that the cell cycle-dependent binding of LBR to chromatin is regulated by phosphorylation in the arginine-serine repeat-containing region by multiple kinases.	Arginine	121-129	lamin B receptor S homeolog	Xenopus laevis	65-68
11917148-1	2002	A crucial role of the P4 arginine in PACE4 inhibition.	Arginine	25-33	proprotein convertase subtilisin/kexin type 6	Homo sapiens	37-42
11795875-9	2002	Previously, an arginine located three residues N-terminal to the site of phosphorylation was thought to be critical for the specificity of MAPKAP-K2.	Arginine	15-23	MAPK activated protein kinase 2	Rattus norvegicus	139-148
11784811-3	2002	Here we show that KCNQ2/KCNQ3 channels carrying a novel BFNC-causing mutation leading to an arginine to tryptophan substitution in the voltage-sensing S4 domain of KCNQ2 subunits (R214W) displayed slower opening and faster closing kinetics and a decreased voltage sensitivity with no concomitant changes in maximal current or plasma membrane expression.	Arginine	92-100	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	18-23
11784811-3	2002	Here we show that KCNQ2/KCNQ3 channels carrying a novel BFNC-causing mutation leading to an arginine to tryptophan substitution in the voltage-sensing S4 domain of KCNQ2 subunits (R214W) displayed slower opening and faster closing kinetics and a decreased voltage sensitivity with no concomitant changes in maximal current or plasma membrane expression.	Arginine	92-100	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	164-169
12144546-3	2002	We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL-4RA.	Arginine	87-90	interleukin 4 receptor	Homo sapiens	123-129
11751582-1	2002	The nuclear hormone receptor co-activator CARM1 has the potential to methylate histone H3 at arginine residues in vitro.	Arginine	93-101	coactivator associated arginine methyltransferase 1	Homo sapiens	42-47
11751582-4	2002	We have raised an antibody that specifically recognizes methylated arginine 17 (R17) of histone H3, the major site of methylation by CARM1.	Arginine	67-75	coactivator associated arginine methyltransferase 1	Homo sapiens	133-138
11747432-1	2001	Argininosuccinate lyase (ASL) catalyzes the reversible breakdown of argininosuccinate to arginine and fumarate, a reaction involved in the biosynthesis of arginine in all species and in the production of urea in ureotelic species.	Arginine	89-97	argininosuccinate lyase	Homo sapiens	0-23
11701890-2	2001	The CBP/p300 methylation site is localized to an arginine residue that is essential for stabilizing the structure of the KIX domain, which mediates CREB recruitment.	Arginine	49-57	cAMP responsive element binding protein 1	Homo sapiens	148-152
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Arginine	208-211	Rac family small GTPase 1	Homo sapiens	24-28
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Arginine	208-211	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Arginine	208-211	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11595749-5	2001	The results reveal that Rac1 residues of both the switch I and switch II regions are involved in GEF docking and GEF-mediated nucleotide disruption, because mutation of Asp(38), Asn(39), Gln(61), Tyr(64), or Arg(66)/Leu(67) into Ala results in the loss of GEF binding, whereas mutation at Tyr(32), Asp(65), or Leu(70)/Ser(71) leads to the loss of GEF catalysis while retaining the binding capability.	Arginine	208-211	Rho/Rac guanine nucleotide exchange factor 2	Homo sapiens	113-116
11747826-0	2001	Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.	Arginine	35-43	coactivator associated arginine methyltransferase 1	Homo sapiens	19-24
11775126-0	2001	The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.	Arginine	32-40	adrenoceptor beta 2	Homo sapiens	61-86
11767101-5	2001	The active site Lys residue in BPTI is replaced by an Arg residue in SETI.	Arginine	54-57	spleen trypsin inhibitor I	Bos taurus	31-35
11748591-6	2001	Results from protein transduction experiments using the synthetic peptides representing residues 109-131 and 123-154 of Pur(alpha) in fusion with the arginine rich domain of HIV-1 Tat revealed cellular internalization and nuclear appearance of the Tat-Pur(alpha) fusion peptide after 2 h and its detection in nuclei up to 24 h after treatment.	Arginine	150-158	purine rich element binding protein A	Homo sapiens	120-130
11748591-6	2001	Results from protein transduction experiments using the synthetic peptides representing residues 109-131 and 123-154 of Pur(alpha) in fusion with the arginine rich domain of HIV-1 Tat revealed cellular internalization and nuclear appearance of the Tat-Pur(alpha) fusion peptide after 2 h and its detection in nuclei up to 24 h after treatment.	Arginine	150-158	purine rich element binding protein A	Homo sapiens	252-262
11713288-6	2001	The extreme C terminus of p53 harbors several lysine residues whose ubiquitination by MDM2 appears to be the initial event in p53 nuclear export, as evidenced by the impaired nucleocytoplasmic shuttling of p53 mutants bearing simultaneous substitutions of lysines 370, 372, 373, 381, 382, and 386 to arginines (6KR) or alanines (6KA).	Arginine	300-309	MDM2 proto-oncogene	Homo sapiens	86-90
11707620-7	2001	The substrate specificity of SGK isoforms superficially resembles that of PKB in that serine and threonine residues lying in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr sequences (where Xaa is a variable amino acid) are phosphorylated.	Arginine	125-128	serum/glucocorticoid regulated kinase 1	Homo sapiens	29-32
11707620-7	2001	The substrate specificity of SGK isoforms superficially resembles that of PKB in that serine and threonine residues lying in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr sequences (where Xaa is a variable amino acid) are phosphorylated.	Arginine	133-136	serum/glucocorticoid regulated kinase 1	Homo sapiens	29-32
11731080-2	2001	We previously developed a fiber-mutant Ad vector containing the Arg-Gly-Asp (RGD)-containing peptide motif on the HI loop of the fiber knob, and showed that the mutant vector had enhanced gene transfer activity to human glioma cells, which showed little CAR expression, compared to the vector containing wild type fiber.	Arginine	64-67	CXADR Ig-like cell adhesion molecule	Homo sapiens	254-257
11676501-1	2001	Arg-Gly-Asp (RGD)-containing peptide is a ligand for integrin alpha(V)beta3 and acts as an angiogenic inhibitor.	Arginine	0-3	integrin subunit alpha V	Homo sapiens	53-75
11779085-2	2001	Integrin alpha(v)beta3 interacts with RGD (Arg-Gly-Asp) sequence-containing proteins in the extracellular matrix.	Arginine	43-46	integrin subunit alpha V	Homo sapiens	0-22
11481325-5	2001	Cleavage of tropoelastin with kallikrein, which cleaves after Arg(515) in the central region of the molecule, disrupted the interaction, suggesting that the separated N- and C-terminal fragments were insufficient to determine MAGP-1 binding to intact tropoelastin.	Arginine	62-65	kallikrein related peptidase 4	Homo sapiens	30-40
11509571-6	2001	We show that the glycine/arginine-rich domain of fibrillarin is necessary and sufficient for SMN binding and that the region of SMN encoded by exon 3, including the Tudor domain, mediates the binding of fibrillarin.	Arginine	25-33	fibrillarin	Homo sapiens	49-60
11603727-9	2001	Blocking of the beta1-integrin with cyclic-peptides containing the Arg-Gly-Asp sequences and antibodies reduced chondrocyte attachment to Type II collagen by 93%.	Arginine	67-70	integrin subunit beta 1	Homo sapiens	16-30
11588148-3	2001	Mutations of specific G(s)alpha residues (Arg(201) or Gln(227)) that are critical for the GTPase reaction lead to constitutive activation of G(s)-coupled signaling pathways, and such somatic mutations are found in endocrine tumors, fibrous dysplasia of bone, and the McCune-Albright syndrome.	Arginine	42-45	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	22-31
11562779-7	2001	The HLA DQB1*0501 peptide ligand sequence showed that proline gives an outstanding signal at position 2, Asn/Arg at P1, aliphatic/aromatic amino acids in the central portion, a hydrophobic cluster at P5 with a small contribution by small polar residues and another cluster of aromatic residues towards the C-terminus.	Arginine	109-112	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
11562779-8	2001	The HLA DQB1*0301 sequence also showed that proline gives an outstanding signal at position 2, Thr/Arg at P1, aliphatic/aromatic amino acids in the central portion and an aliphatic cluster with a small contribution by small polar residues at P5.	Arginine	99-102	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	4-12
11588525-0	2001	Increased contribution of L-arginine-nitric oxide pathway in aorta of mice lacking the gene for vimentin.	Arginine	26-36	vimentin	Mus musculus	96-104
11575928-6	2001	This alteration might allow MMP-12 to accept P1" Arg residues, making it unique among MMPs.	Arginine	49-52	matrix metallopeptidase 12	Homo sapiens	28-34
11544342-6	2001	CDR3 regions of both IgH and TCR from peripheral lymphocytes of MRL-Fas(lpr) mice are shorter in the absence of TdT, and there is a paucity of arginines in the IgH CDR3 regions of the MRL-Fas(lpr) TdT(-/-) mice.	Arginine	143-152	immunoglobulin heavy chain complex	Mus musculus	21-24
11483748-0	2001	The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.	Arginine	4-12	KRAS proto-oncogene, GTPase	Homo sapiens	77-80
11483748-0	2001	The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.	Arginine	4-12	KRAS proto-oncogene, GTPase	Homo sapiens	114-117
11483748-3	2001	Amino acid sequence analysis revealed that the NS3 protein contains seven RG motifs, including two potential RG motifs in the 1486-QRRGRTGRG-1494 motif IV of the RNA helicase domain, in which arginines are potentially methylated by PRMTs.	Arginine	192-201	KRAS proto-oncogene, GTPase	Homo sapiens	47-50
11483748-4	2001	Indeed, we found that the full-length NS3 protein is arginine methylated in vivo.	Arginine	53-61	KRAS proto-oncogene, GTPase	Homo sapiens	38-41
11483748-8	2001	Mutational analyses indicate that the Arg(1493) in the QRR(1488)GRTGR(1493)G region of the NS3 RNA helicase is essential for NS3 protein methylation and that Arg(1488) is likely methylated.	Arginine	38-41	KRAS proto-oncogene, GTPase	Homo sapiens	91-94
11483748-8	2001	Mutational analyses indicate that the Arg(1493) in the QRR(1488)GRTGR(1493)G region of the NS3 RNA helicase is essential for NS3 protein methylation and that Arg(1488) is likely methylated.	Arginine	38-41	KRAS proto-oncogene, GTPase	Homo sapiens	125-128
11483748-8	2001	Mutational analyses indicate that the Arg(1493) in the QRR(1488)GRTGR(1493)G region of the NS3 RNA helicase is essential for NS3 protein methylation and that Arg(1488) is likely methylated.	Arginine	158-161	KRAS proto-oncogene, GTPase	Homo sapiens	91-94
11483748-9	2001	NS3 protein methylation by the PRMT1 was decreased in the presence of homoribopolymers, suggesting that the arginine-rich motif IV is involved in RNA binding.	Arginine	108-116	KRAS proto-oncogene, GTPase	Homo sapiens	0-3
11483748-9	2001	NS3 protein methylation by the PRMT1 was decreased in the presence of homoribopolymers, suggesting that the arginine-rich motif IV is involved in RNA binding.	Arginine	108-116	protein arginine methyltransferase 1	Homo sapiens	31-36
11483748-10	2001	The results suggest that an arginine residue(s) in QRXGRXGR motif IV conserved in the virus-encoded RNA helicases can be posttranslationally methylated by the PRMT1.	Arginine	28-36	protein arginine methyltransferase 1	Homo sapiens	159-164
11513582-8	2001	The active site of thrombin is filled with eight consecutive amino acids of ecotin and demonstrates thrombin"s preference for specific features that are compatible with the thrombin cleavage site: negatively charged-Pro-Val-X-Pro-Arg-hydrophobic-positively charged (P1 Arg is in bold letters).	Arginine	230-233	coagulation factor II, thrombin	Bos taurus	19-27
11513582-8	2001	The active site of thrombin is filled with eight consecutive amino acids of ecotin and demonstrates thrombin"s preference for specific features that are compatible with the thrombin cleavage site: negatively charged-Pro-Val-X-Pro-Arg-hydrophobic-positively charged (P1 Arg is in bold letters).	Arginine	230-233	coagulation factor II, thrombin	Bos taurus	100-108
11513582-8	2001	The active site of thrombin is filled with eight consecutive amino acids of ecotin and demonstrates thrombin"s preference for specific features that are compatible with the thrombin cleavage site: negatively charged-Pro-Val-X-Pro-Arg-hydrophobic-positively charged (P1 Arg is in bold letters).	Arginine	230-233	coagulation factor II, thrombin	Bos taurus	100-108
11511108-6	2001	Another potent and selective compound was cyclo(NH-CH(2)-CH(2)-CO-His-d-Phe-Arg-Trp-Glu)-NH(2): EC(50) about 1 nM at hMC-4R, with 90-fold selectivity over hMC-3R and greater than 2000-fold selectivity over hMC-5R.	Arginine	76-79	melanocortin 4 receptor	Homo sapiens	117-123
11511108-6	2001	Another potent and selective compound was cyclo(NH-CH(2)-CH(2)-CO-His-d-Phe-Arg-Trp-Glu)-NH(2): EC(50) about 1 nM at hMC-4R, with 90-fold selectivity over hMC-3R and greater than 2000-fold selectivity over hMC-5R.	Arginine	76-79	melanocortin 5 receptor	Homo sapiens	206-212
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	65-68	sulfotransferase family 1A member 3	Homo sapiens	28-31
11485566-4	2001	The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE.	Arginine	110-113	sulfotransferase family 1A member 3	Homo sapiens	28-31
11454467-2	2001	The incorporated octapeptide, Gly-Pro-Gln-Arg-Ile-Ala-Gly-Gln, in A-DP2 is not cleaved by activated MMP2 and MMP9 in contrast to Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln incorporated in A-DP1 that is cleaved efficiently by activated MMP2 and MMP9 liberating a doxorubicin tetrapeptide.	Arginine	42-45	matrix metallopeptidase 2	Mus musculus	224-228
11435565-3	2001	We have found that mutation of an absolutely conserved arginine (Arg) residue at position 50 to alanine (R50A) of the simian foamy virus SFV cpz(hu) inhibits proper capsid assembly and abolishes viral budding even in the presence of the envelope (Env) glycoproteins.	Arginine	55-63	endogenous retrovirus group K member 20	Homo sapiens	247-250
11435565-3	2001	We have found that mutation of an absolutely conserved arginine (Arg) residue at position 50 to alanine (R50A) of the simian foamy virus SFV cpz(hu) inhibits proper capsid assembly and abolishes viral budding even in the presence of the envelope (Env) glycoproteins.	Arginine	65-68	endogenous retrovirus group K member 20	Homo sapiens	247-250
11513091-0	2001	Purification of non-toxic, biodegradable arginine-based gemini surfactants, bis(Args), by ion exchange chromatography.	Arginine	41-49	serpin family A member 2 (gene/pseudogene)	Homo sapiens	80-84
11509230-6	2001	SMN interaction requires the arginine- and glycine-rich domains of both fibrillarin and GAR1 and is defective in SMN mutants found in some SMA patients.	Arginine	29-37	fibrillarin	Homo sapiens	72-83
11509230-6	2001	SMN interaction requires the arginine- and glycine-rich domains of both fibrillarin and GAR1 and is defective in SMN mutants found in some SMA patients.	Arginine	29-37	GAR1 ribonucleoprotein	Homo sapiens	88-92
11439102-0	2001	Involvement of the chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase sequence His444-Arg-Glu-Arg in modulation of the bisphosphatase activity by its kinase domain.	Arginine	102-105	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Gallus gallus	33-85
11352902-9	2001	These results suggest that Arg(49) and Asp(50) may be targeted for the design of potent and selective inhibitors of TCPTP and PTP1B.	Arginine	27-30	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	126-131
11494128-4	2001	Two-hybrid screens identified regions of Abl and Arg that bind to the EphB2 and EphA4 receptors, suggesting a novel signaling connection involving the two kinase families.	Arginine	49-52	EPH receptor A4	Homo sapiens	80-85
11463775-6	2001	Purified ACE degraded D-Arg-[Hyp(3)]-BK and [Hyp,(3) Tyr(Me)(8)]-BK at 81% and 71% of BK degradation activity, respectively, whereas other peptides were highly ([DeltaPhe(5)]-BK) or completely ([D-NMF(7)]-BK, [Phe(8)psi(CH(2)-NH)Arg(9)]-BK) resistant.	Arginine	24-27	angiotensin-converting enzyme	Oryctolagus cuniculus	9-12
11413387-6	2001	The PB1 epitope is only the fourth D(k)-presented peptide to be reported and the sequence of this epitope confirms a D(k)-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.	Arginine	162-170	polybromo 1	Homo sapiens	4-7
11413387-6	2001	The PB1 epitope is only the fourth D(k)-presented peptide to be reported and the sequence of this epitope confirms a D(k)-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.	Arginine	188-196	polybromo 1	Homo sapiens	4-7
11448779-0	2001	Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1.	Arginine	29-37	H4 clustered histone 9	Homo sapiens	15-25
11448779-0	2001	Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1.	Arginine	29-37	protein arginine methyltransferase 1	Homo sapiens	107-112
11448779-5	2001	Here we show by using mass spectrometry that histone H4, isolated from asynchronously growing human 293T cells, is methylated at arginine 3 (Arg-3) in vivo.	Arginine	129-137	H4 clustered histone 9	Homo sapiens	45-55
11448779-5	2001	Here we show by using mass spectrometry that histone H4, isolated from asynchronously growing human 293T cells, is methylated at arginine 3 (Arg-3) in vivo.	Arginine	141-144	H4 clustered histone 9	Homo sapiens	45-55
11448779-6	2001	In support, a novel antibody directed against histone H4 methylated at Arg-3 independently demonstrates the in vivo occurrence of this modification and reveals that H4 Arg-3 methylation is highly conserved throughout eukaryotes.	Arginine	71-74	H4 clustered histone 9	Homo sapiens	46-56
11448779-6	2001	In support, a novel antibody directed against histone H4 methylated at Arg-3 independently demonstrates the in vivo occurrence of this modification and reveals that H4 Arg-3 methylation is highly conserved throughout eukaryotes.	Arginine	168-171	H4 clustered histone 9	Homo sapiens	46-56
11278650-6	2001	Two residues were identified in the FKN-CD, namely Lys-7 and Arg-47, that are important determinants in mediating an FKN-CX3CR1 interaction.	Arginine	61-64	C-X3-C motif chemokine receptor 1	Homo sapiens	121-127
11279053-5	2001	Arginine 118 on MAG is known to make a key contact with sialic acid.	Arginine	0-8	myelin associated glycoprotein	Homo sapiens	16-19
11278454-8	2001	The cellular protein, ASF/SF2, a member of the serine- and arginine-rich family of splicing factors (SR proteins) bound to repeated sequences within the 55-nucleotide RRE region.	Arginine	59-67	serine and arginine rich splicing factor 1	Homo sapiens	22-29
11419962-6	2001	The l -arginine pretreatment attenuated the increases in iNOS and MPO activities and nitrite/nitrate concentration and the decrease in cNOS activity in the gastric mucosal tissue in a dose-dependent manner, while the d -arginine pretreatment did not.	Arginine	4-15	nitric oxide synthase 3	Rattus norvegicus	135-139
11279090-5	2001	Arg-166 is conserved in all cytochromes c(1) and lies on the surface of Cyt1p in close proximity to the heme group but does not seem to interact directly with any of the physiological partners of the cytochrome bc(1) complex.	Arginine	0-3	ubiquinol--cytochrome-c reductase catalytic subunit CYT1	Saccharomyces cerevisiae S288C	72-77
11278397-3	2001	We have demonstrated also that LAT1 response to arginine availability is lost in transformed and tumorigenic cells such that expression is constitutively high.	Arginine	48-56	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	31-35
11278397-7	2001	Overexpression of LAT1 alone in mouse hepatocytes, but not fibroblasts, was sufficient to increase system l transport, and these cells displayed a growth advantage in conditions of limited arginine.	Arginine	189-197	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	18-22
11379758-6	2001	PHBP cleaved the C-terminal side of Arg in the peptide effectively and that of Lys weakly.	Arginine	36-39	hyaluronan binding protein 2	Homo sapiens	0-4
11389857-2	2001	SMN binds the arginine- and glycine-rich (RG) domains of the snRNP proteins SmD1 and SmD3.	Arginine	14-22	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	76-80
11322789-6	2001	Additional mutation analyses demonstrated that Arg(390) is the most critical moiety within this region that mediated GKLF function and its nucleus localization.	Arginine	47-50	Kruppel like factor 4	Homo sapiens	117-121
11322789-7	2001	Cotransfection of Arg(390) mutant (RR/RS) completely inhibited wild-type GKLF function, and GFP-RR/RS GKLF fusion proteins failed to translocate to the nucleus.	Arginine	18-21	Kruppel like factor 4	Homo sapiens	73-77
11322789-8	2001	The results from this study demonstrate that Arg(390) confers the NLS of GKLF and that the nucleus-localization-deficient mutant serves as dominant-negative inhibitor of GKLF function.	Arginine	45-48	Kruppel like factor 4	Homo sapiens	73-77
11309624-3	2001	The resulting 33K carboxy-terminal fragment of SCC1 bears an amino-terminal arginine-a destabilizing residue in the N-end rule.	Arginine	76-84	kleisin alpha	Saccharomyces cerevisiae S288C	47-51
11290609-3	2001	ARG is a widely expressed tyrosine kinase that shares substantial sequence identity with c-ABL in the kinase domain and cooperates with ABL to regulate neurulation in the developing mouse embryo.	Arginine	0-3	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	89-94
11290609-3	2001	ARG is a widely expressed tyrosine kinase that shares substantial sequence identity with c-ABL in the kinase domain and cooperates with ABL to regulate neurulation in the developing mouse embryo.	Arginine	0-3	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	91-94
11290609-4	2001	As described here, ARG has recently been implicated in the pathogenesis of leukemia as a fusion partner of TEL.	Arginine	19-22	ets variant 6	Mus musculus	107-110
11294634-2	2001	Cationic interfacial binding residues of A. p. piscivorus PLA(2) (Lys-10) and human group IIa PLA(2) (Arg-7, Lys-10, and Lys-16), which mediate electrostatic interactions with anionic membranes, primarily accelerate the membrane association.	Arginine	102-105	phospholipase A2 group IIA	Homo sapiens	58-64
11294634-2	2001	Cationic interfacial binding residues of A. p. piscivorus PLA(2) (Lys-10) and human group IIa PLA(2) (Arg-7, Lys-10, and Lys-16), which mediate electrostatic interactions with anionic membranes, primarily accelerate the membrane association.	Arginine	102-105	phospholipase A2 group IIA	Homo sapiens	94-100
11278261-4	2001	The present studies demonstrate that ARG associates with the proapoptotic Siva-1 protein.	Arginine	37-40	SIVA1 apoptosis inducing factor	Homo sapiens	74-80
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	35-38	SIVA1 apoptosis inducing factor	Homo sapiens	39-45
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	35-38	SIVA1 apoptosis inducing factor	Homo sapiens	192-198
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	91-94	SIVA1 apoptosis inducing factor	Homo sapiens	39-45
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	91-94	SIVA1 apoptosis inducing factor	Homo sapiens	192-198
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	91-94	SIVA1 apoptosis inducing factor	Homo sapiens	39-45
11278261-5	2001	The functional significance of the ARG-Siva-1 interaction is supported by the finding that ARG is activated by oxidative stress and that this response involves ARG-mediated phosphorylation of Siva-1 on Tyr(48).	Arginine	91-94	SIVA1 apoptosis inducing factor	Homo sapiens	192-198
11278261-6	2001	The proapoptotic effects of Siva-1 are accentuated in cells stably expressing ARG and are inhibited in ARG-deficient cells.	Arginine	78-81	SIVA1 apoptosis inducing factor	Homo sapiens	28-34
11278261-6	2001	The proapoptotic effects of Siva-1 are accentuated in cells stably expressing ARG and are inhibited in ARG-deficient cells.	Arginine	103-106	SIVA1 apoptosis inducing factor	Homo sapiens	28-34
11278261-9	2001	These findings support a model in which the activation of ARG by oxidative stress induces apoptosis by a Siva-1-dependent mechanism.	Arginine	58-61	SIVA1 apoptosis inducing factor	Homo sapiens	105-111
11308397-7	2001	RESULTS: Mutation analysis of all 3 collagen IX genes resulted in identification of an Arg103-->Trp (arginine-->tryptophan) substitution in the alpha3 chain (Trp3 allele).	Arginine	101-109	paired box 5	Homo sapiens	30-35
11308397-7	2001	RESULTS: Mutation analysis of all 3 collagen IX genes resulted in identification of an Arg103-->Trp (arginine-->tryptophan) substitution in the alpha3 chain (Trp3 allele).	Arginine	101-109	collagen type IX alpha 3 chain	Homo sapiens	158-162
11179776-0	2001	The inhibitory mechanism of GLP-1, but not glucagon, on fasted gut motility is dependent on the L-arginine/nitric oxide pathway.	Arginine	96-106	glucagon	Rattus norvegicus	28-33
11179776-6	2001	Similarly, L-arginine at 300 mg x kg(-1) prevented L-NNA-induced disinhibition of the GLP-1 response (P&lt;0.05).	Arginine	11-21	glucagon	Rattus norvegicus	86-91
11401448-4	2001	CNRc1 and c2 lack the Arg-Gly-Asp (RGD) sequence that is conserved in the EC1 of CNR1-8, which is necessary for binding to Reelin.	Arginine	22-25	reelin	Homo sapiens	123-129
11159030-3	2001	After treatment, the state of the actin cytoskeleton, L-arginine uptake mediated by the cationic amino acid transporter-1 (CAT-1), Ca(2+)/calmodulin-dependent (endothelial) NO synthase (eNOS) activity and content, and NO production were examined.	Arginine	54-64	solute carrier family 7 member 1	Homo sapiens	88-121
11250869-4	2001	When expressed in Xenopus laevis oocytes, hCAT-1-mediated L-arginine transport was reduced to 44+/-3% after a 30 min treatment of the oocytes with 100 nM phorbol-12-myristate-13-acetate (PMA).	Arginine	58-68	solute carrier family 7 member 1	Homo sapiens	42-48
11250869-7	2001	In EA.hy926 endothelial cells, maximal inhibition of hCAT-1-mediated L-arginine transport (to 3 -- 11% of control) was observed after treatment of the cells with 100 nM PMA for 4 h. A 20 -- 30 h exposure of the cells to 100 nM PMA led to the recovery of the L-arginine uptake rate that was now resistant to a second application of PMA.	Arginine	69-79	solute carrier family 7 member 1	Homo sapiens	53-59
11250869-7	2001	In EA.hy926 endothelial cells, maximal inhibition of hCAT-1-mediated L-arginine transport (to 3 -- 11% of control) was observed after treatment of the cells with 100 nM PMA for 4 h. A 20 -- 30 h exposure of the cells to 100 nM PMA led to the recovery of the L-arginine uptake rate that was now resistant to a second application of PMA.	Arginine	258-268	solute carrier family 7 member 1	Homo sapiens	53-59
11305031-7	2001	L-arginine increased cyclic GMP production in elderly controls, but not in hypercholesterolemic patients (p &lt; 0.02).	Arginine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	28-31
11249066-7	2001	In the in vitro study, clusterin mRNA and protein were strongly induced in AR4-2J cells treated either with arginine, menadione, tumor necrosis factor-alpha or transforming growth factor-beta1.	Arginine	108-116	clusterin	Rattus norvegicus	23-32
11249066-8	2001	In the time course study with arginine or menadione, clusterin mRNA was expressed after 4 hours and peaked at 8 and 24 hours, whereas DNA fragmentation peaked at 72 hours.	Arginine	30-38	clusterin	Rattus norvegicus	53-62
11257260-7	2001	The sequence of ATP-binding cassette transporter 1 (ABC1-1) cDNA obtained by reverse transcription-PCR (RT-PCR) of total RNA isolated from cultured fibroblasts showed that the proband was homozygous for a C&gt;T transition in exon 13, which caused a tryptophane for arginine substitution (R527W).	Arginine	266-274	ATP binding cassette subfamily A member 1	Homo sapiens	52-58
11354794-8	2001	It was found that L-arginine significantly inhibited the increase of MABP and LVW/BW, attenuated the activity of MAPK, increased protein expression of eNOS and MKP-1 and potentiated production of NO in cardiac tissue with the most effective dosage of 150 mg/kg, and these effects of L-arginine could be inhibited by L-NAME.	Arginine	18-28	nitric oxide synthase 3	Rattus norvegicus	151-155
11354794-10	2001	The anti-hypertrophic effects of L-arginine may involve increase of eNOS protein expression and NO production, potentiation of MKP-1 protein expression, and inhibition of MAPK activity in the cardiac tissue of RHR.	Arginine	33-43	nitric oxide synthase 3	Rattus norvegicus	68-72
11920243-9	2001	Our results also demonstrate that Arg 1715 is not essential in the function but it is necessary for maintaining the conformation recognized by MoAb 9 specific for the GPIIb/IIIa-binding domain of VWF.	Arginine	34-37	integrin subunit alpha 2b	Homo sapiens	167-172
11163232-1	2001	The rat MHC class Ia molecule RT1-Aa has the unusual capacity to bind long peptides ending in arginine, such as MTF-E, a thirteen-residue, maternally transmitted minor histocompatibility antigen.	Arginine	94-102	RT1 class I, locus A	Rattus norvegicus	30-36
11160363-0	2001	Three arginine residues in apolipoprotein A-I are critical for activation of lecithin:cholesterol acyltransferase.	Arginine	6-14	lecithin-cholesterol acyltransferase	Homo sapiens	77-113
11160363-12	2001	Three arginine residues in apolipoportein A-I are critical for activation of lecithin:cholesterol acyltransferase J.	Arginine	6-14	lecithin-cholesterol acyltransferase	Homo sapiens	77-113
11190986-9	2001	In contrast, Cytotoxic T cells (CD8+) showed a dose dependent proliferation in response to L-arginine (p = .01).	Arginine	91-101	CD8a molecule	Homo sapiens	32-35
11190986-10	2001	Of the CD8+ cells, an increase in the CD45RA negative CD8 positive (memory) T cell subpopulation was observed with the addition of L-arginine.	Arginine	131-141	CD8a molecule	Homo sapiens	7-10
11190986-10	2001	Of the CD8+ cells, an increase in the CD45RA negative CD8 positive (memory) T cell subpopulation was observed with the addition of L-arginine.	Arginine	131-141	CD8a molecule	Homo sapiens	54-57
11190986-11	2001	In addition, the number of cell surface CD8 receptors (CD8R) and CD3 receptors (CD3R) increased in the presence of L-arginine (p = .01, p = .04).	Arginine	115-125	CD8a molecule	Homo sapiens	40-43
11369811-6	2001	Aortic constitutive nitric oxide synthase (cNOS) activity was determined by measuring the conversion of L-arginine to L-citrulline.	Arginine	104-114	nitric oxide synthase 3	Rattus norvegicus	43-47
11138972-0	2001	Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro.	Arginine	86-94	glucagon	Rattus norvegicus	24-47
11138972-5	2001	However, GLP-1 promptly inhibited the arginine-induced glucagon release (p &lt; 0.02).	Arginine	38-46	glucagon	Rattus norvegicus	9-14
11138972-6	2001	In contrast, CCK enhanced insulin release in response to arginine both in the perfused rat pancreas and in vivo in mice (p &lt; 0.001).	Arginine	57-65	cholecystokinin	Rattus norvegicus	13-16
11138972-9	2001	Furthermore, GLP-1 directly inhibited arginine-induced glucagon release as no concurrent increase in insulin or somatostatin release was noted.	Arginine	38-46	glucagon	Rattus norvegicus	13-18
12120187-8	2001	The herbal medicines and two components suppressed PAP mRNA expression and enhanced Mn-SOD and iNOS mRNA expression in arginine-treated AR4-2J cells.	Arginine	119-127	superoxide dismutase 2	Rattus norvegicus	84-90
10984491-1	2000	The prothrombinase complex, composed of the proteinase, factor Xa, bound to factor Va on membranes, catalyzes thrombin formation by the specific and ordered proteolysis of prothrombin at Arg(323)-Ile(324), followed by cleavage at Arg(274)-Thr(275).	Arginine	187-190	coagulation factor II, thrombin	Bos taurus	7-15
10984491-1	2000	The prothrombinase complex, composed of the proteinase, factor Xa, bound to factor Va on membranes, catalyzes thrombin formation by the specific and ordered proteolysis of prothrombin at Arg(323)-Ile(324), followed by cleavage at Arg(274)-Thr(275).	Arginine	230-233	coagulation factor II, thrombin	Bos taurus	7-15
11099312-8	2000	Hence, in these two TCR the Arg-Asp motif is clearly involved in contacting Ni-MHC complexes, and close cooperation between alpha and ss chain is required.	Arginine	28-31	major histocompatibility complex, class I, C	Homo sapiens	79-82
11118068-0	2000	Interaction between HIV type 1 glycoprotein 120 and CXCR4 coreceptor involves a highly conserved arginine residue in hypervariable region 3.	Arginine	97-105	C-X-C motif chemokine receptor 4	Homo sapiens	52-57
11118068-5	2000	Previously, we reported that a highly conserved arginine residue of V3 played an important role in CCR5 utilization.	Arginine	48-56	C-C motif chemokine receptor 5	Homo sapiens	99-103
11118068-6	2000	In this study, the possible involvement of the same arginine residue in CXCR4 utilization was investigated.	Arginine	52-60	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
11118068-7	2000	Amino acid substitutions introduced to this arginine on R5X4 viruses were found to have a significant effect on their utilization of CXCR4.	Arginine	44-52	C-X-C motif chemokine receptor 4	Homo sapiens	133-138
11036023-7	2000	Likewise, certain characteristic structural features of CTX-M enzymes, such as Phe-160, Ser-237, and Arg-276, were observed for BES-1, which, in addition, harbored different residues (Ala-104, Ser-171, Arg-220, Gly-240) and six additional residues at the end of the sequence.	Arginine	101-104	BES-1	Serratia marcescens	128-133
11036023-7	2000	Likewise, certain characteristic structural features of CTX-M enzymes, such as Phe-160, Ser-237, and Arg-276, were observed for BES-1, which, in addition, harbored different residues (Ala-104, Ser-171, Arg-220, Gly-240) and six additional residues at the end of the sequence.	Arginine	202-205	BES-1	Serratia marcescens	128-133
11054123-9	2000	The distinct Arg/Lys-rich and Met-rich region at positions 10-36 of the PLA2 homolog presumably are involved in its heparin-binding and the cell membrane-interference leading to edema and myotoxicity.	Arginine	13-16	phospholipase A2 group IIA	Homo sapiens	72-76
11144293-2	2000	A single-nucleotide polymorphism in TNFR2, which is involved in an amino acid substitution [methionine(M)/arginine(R)] at position 196, was investigated in 149 Japanese narcoleptic patients and 204 healthy individuals as controls.	Arginine	106-114	TNF receptor superfamily member 1B	Homo sapiens	36-41
10945985-3	2000	H4B-free nNOS catalyzed Arg oxidation to N(omega)-hydroxy-l-Arg (NOHA) and citrulline in both NADPH- and H(2)O(2)-driven reactions.	Arginine	24-27	H4 clustered histone 4	Homo sapiens	0-3
10896665-0	2000	Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.	Arginine	81-89	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	105-110
10859313-10	2000	Substitution of a single arginine residue (Arg-728) of Rab3-GAP disrupted its catalytic activity but not its interaction with Rab3A.	Arginine	25-33	RAB3 GTPase activating protein catalytic subunit 1	Homo sapiens	55-63
10859313-10	2000	Substitution of a single arginine residue (Arg-728) of Rab3-GAP disrupted its catalytic activity but not its interaction with Rab3A.	Arginine	43-46	RAB3 GTPase activating protein catalytic subunit 1	Homo sapiens	55-63
10859313-11	2000	We propose that Rab3-GAP, like Ras- and Rho-GAPs, stabilizes the transition state of Rab3 and provides a critical arginine residue to accelerate the GTPase reaction.	Arginine	114-122	RAB3 GTPase activating protein catalytic subunit 1	Homo sapiens	16-24
10978617-6	2000	The K(in), K(cat) and K(cat)/K(m) values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 6.21x10(4) s(-1)M(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 3.62x10(4) s(-1)M(-1) for Ala-Arg-MCA, respectively.	Arginine	133-136	dipeptidylpeptidase 3	Rattus norvegicus	44-51
10978617-6	2000	The K(in), K(cat) and K(cat)/K(m) values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 6.21x10(4) s(-1)M(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 3.62x10(4) s(-1)M(-1) for Ala-Arg-MCA, respectively.	Arginine	137-140	dipeptidylpeptidase 3	Rattus norvegicus	44-51
10978617-6	2000	The K(in), K(cat) and K(cat)/K(m) values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 6.21x10(4) s(-1)M(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 3.62x10(4) s(-1)M(-1) for Ala-Arg-MCA, respectively.	Arginine	137-140	dipeptidylpeptidase 3	Rattus norvegicus	44-51
10998238-1	2000	Integrin alpha(V)beta(3) plays a crucial role in angiogenesis, apoptosis, and bone remodeling, mainly by interacting with matrix proteins through recognition of an Arg-Gly-Asp (RGD) motif.	Arginine	164-167	integrin subunit alpha V	Homo sapiens	0-24
10846172-5	2000	Thus, it appears that Trp(676), Trp(678), and Phe(691) are important to retain the appropriate active site conformation for H4B/l-Arg binding and/or electron transfer to the heme from NADPH.	Arginine	130-133	H4 clustered histone 4	Homo sapiens	124-127
10846172-9	2000	Thus, hydrogen bond networks consisting of the heme carboxylate, Tyr(706), and Arg(414) are crucial in stabilizing the appropriate conformation(s) of the heme active site for H4B/l-Arg binding and/or efficient electron transfer to occur.	Arginine	79-82	H4 clustered histone 4	Homo sapiens	175-178
10846172-9	2000	Thus, hydrogen bond networks consisting of the heme carboxylate, Tyr(706), and Arg(414) are crucial in stabilizing the appropriate conformation(s) of the heme active site for H4B/l-Arg binding and/or efficient electron transfer to occur.	Arginine	181-184	H4 clustered histone 4	Homo sapiens	175-178
10851237-4	2000	We show that unique carboxyl-terminal arginine- and glycine-rich domains comprising the last 29 amino acids of SmD1 and the last 32 amino acids of SmD3 are necessary and sufficient for SMN binding.	Arginine	38-46	small nuclear ribonucleoprotein D1 polypeptide	Homo sapiens	111-115
10952997-6	2000	Remarkably, arginine methylation interferes with Sky1p-mediated phosphorylation, thereby indirectly influencing the Npl3p-Mtr10p interaction in vivo and negatively regulating nuclear import of Npl3p.	Arginine	12-20	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	116-121
10952997-6	2000	Remarkably, arginine methylation interferes with Sky1p-mediated phosphorylation, thereby indirectly influencing the Npl3p-Mtr10p interaction in vivo and negatively regulating nuclear import of Npl3p.	Arginine	12-20	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	193-198
10963786-6	2000	Blocking of GPIIb-IIIa by Arg-Gly-Asp-Ser peptide prevented platelet adhesion to the polystyrene while an extensive adhesion of single platelets to extracellular matrix was observed.	Arginine	26-29	integrin subunit alpha 2b	Homo sapiens	12-17
10938011-9	2000	In vitro studies of the function of NOV protein showed that it promoted VSMC adhesion via a mechanism that was divalent cation and Arg-Gly-Asp independent but that it did not modulate VSMC proliferation or phenotype.	Arginine	131-134	cellular communication network factor 3	Rattus norvegicus	36-39
10959581-2	2000	Absolute requirement of the arginine residue at position 7 of dog neuromedin U-8 for contractile activity.	Arginine	28-36	neuromedin-U-25	Canis lupus familiaris	66-78
10906155-3	2000	Components of the L-arginine metabolic pathway, especially inducible nitric oxide (NO) synthase (iNOS), ornithine aminotransferase (OAT), and ornithine decarboxylase (ODC), have been associated with glomerular scarring.	Arginine	18-28	ornithine decarboxylase, structural 1	Mus musculus	142-165
10889340-2	2000	Myelin basic protein is methylated on one arginine group.	Arginine	42-50	myelin basic protein	Rattus norvegicus	0-20
10899108-5	2000	A central arginine residue from p35 projects into a deep pocket on p40, which may be an ideal target for a small molecule antagonist of IL-12 formation.	Arginine	10-18	interleukin 12A	Homo sapiens	32-35
10860637-9	2000	These results suggest that the mechanisms, involved in the relaxation induced by A II in the isolated mouse tracheal rings precontracted by carbachol, were firstly l -arginine NO and cyclo-oxygenase products of arachidonic acid, secondly K(+)channels.	Arginine	164-175	arginase type II	Mus musculus	81-85
10928480-6	2000	DNA sequencing analysis revealed a novel missense mutation in the GPIbbeta gene that converts Pro (CCG) to Arg (CGG) at residue 74.	Arginine	107-110	glycoprotein Ib platelet subunit alpha	Homo sapiens	66-74
10839988-5	2000	Product analysis of the methylated [methyl-(14)C]SRB-peptide by HPLC indicated the formation of N(G)-monomethylarginine and N(G),N(G)-dimethyl(asymmetric)arginine.	Arginine	153-162	chaperonin containing TCP1 subunit 4	Homo sapiens	49-52
10800966-3	2000	ADC decarboxylates both arginine (Km = 0.75 mM) and ornithine (Km = 0.25 mM), a reaction not inhibited by the specific ODC inhibitor, difluoromethylomithine.	Arginine	24-32	antizyme inhibitor 2	Rattus norvegicus	0-3
10775626-7	2000	Analysis of the envelope V3 loop sequence linked a threonine or arginine at position 319 (numbering based on the HXB2 genome) with AOP-RANTES resistance.	Arginine	64-72	C-C motif chemokine ligand 5	Homo sapiens	135-141
10777584-7	2000	RAZ1 is a novel cDNA that encodes a SCAN-related domain and arginine-rich region but no zinc finger motifs.	Arginine	60-68	SCAN domain containing 1	Homo sapiens	0-4
10753964-0	2000	Amyloid and non-amyloid forms of 5q31-linked corneal dystrophy resulting from kerato-epithelin mutations at Arg-124 are associated with abnormal turnover of the protein.	Arginine	108-111	transforming growth factor beta induced	Homo sapiens	78-94
10753964-3	2000	Herein, we studied the corneas with mutations at kerato-epithelin residue Arg-124 resulting in amyloid (R124C), non-amyloid (R124L), and a mixed pattern of deposition (R124H).	Arginine	74-77	transforming growth factor beta induced	Homo sapiens	49-65
10753964-10	2000	It appears that substitutions at the same residue (Arg-124) result in cornea-specific deposition of kerato-epithelin via distinct aggregation pathways each involving altered turnover of the protein in corneal tissue.	Arginine	51-54	transforming growth factor beta induced	Homo sapiens	100-116
10763825-3	2000	In this study, the kinase specificities of the Bcr-Abl and Tel-Abl proteins were compared to the physiological Abl family kinases c-Abl and Arg (abl related gene).	Arginine	140-143	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	145-148
10763825-9	2000	The results indicate that the leukaemic Abl-fusion proteins have catalytic specificities different from the normal kinases c-Abl and Arg and that Tel-Abl is capable to activate at least some pathways which are also upregulated by Bcr-Abl.	Arginine	133-136	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-43
10706884-7	2000	Although the ABL is known to be involved in various human malignancies, ARG has not been involved in human malignancies despite its high homology to ABL.	Arginine	72-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	149-152
10691982-3	2000	In an attempt to decipher the role of H230 (H231 of the human enzyme) in the catalytic mechanism and/or maintenance of oligomeric structure of sheep liver serine hydroxymethyltransferase, the residue was mutated to arginine, phenylalanine, alanine, asparagine or tyrosine.	Arginine	215-223	serine hydroxymethyltransferase, cytosolic	Ovis aries	155-186
10699171-9	2000	Mutation of a conserved arginine residue in the rhoGAP domain prevents the loss of stress fibers but has little effect on process outgrowth.	Arginine	24-32	Rho GTPase activating protein 1	Homo sapiens	48-54
10672029-1	2000	Wounding of tomato leaves results in the accumulation of an exoprotease called leucine aminopeptidase (LAP-A) that preferentially hydrolyzes amino acid-p-nitroanilide and -beta-naphthylamide substrates with N-terminal Leu, Met and Arg residues.	Arginine	231-234	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	79-101
10672029-1	2000	Wounding of tomato leaves results in the accumulation of an exoprotease called leucine aminopeptidase (LAP-A) that preferentially hydrolyzes amino acid-p-nitroanilide and -beta-naphthylamide substrates with N-terminal Leu, Met and Arg residues.	Arginine	231-234	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	103-108
10722119-0	2000	Hb Siam [alpha15(A13)Gly-->Arg] is a GGT-->CGT mutation in the alpha1-globin gene.	Arginine	27-30	UDP glycosyltransferase 8	Homo sapiens	43-46
11778498-3	2000	RESULTS: (1) The distribution frequency of genotype beta 2-AR 16 loci: Arg/Arg genotype accounts for 13%, Arg/Gly 76% and Gly/Gly 11%.	Arginine	71-74	adrenoceptor beta 2	Homo sapiens	52-61
11778498-3	2000	RESULTS: (1) The distribution frequency of genotype beta 2-AR 16 loci: Arg/Arg genotype accounts for 13%, Arg/Gly 76% and Gly/Gly 11%.	Arginine	75-78	adrenoceptor beta 2	Homo sapiens	52-61
11778498-3	2000	RESULTS: (1) The distribution frequency of genotype beta 2-AR 16 loci: Arg/Arg genotype accounts for 13%, Arg/Gly 76% and Gly/Gly 11%.	Arginine	75-78	adrenoceptor beta 2	Homo sapiens	52-61
11778498-6	2000	(2) The frequency of genotype beta 2-AR 16 loci in asthmatics: Arg/Arg genotype accounts for 24%, Arg/Gly 45% and Gly/Gly 31%.	Arginine	63-66	adrenoceptor beta 2	Homo sapiens	30-39
11778498-6	2000	(2) The frequency of genotype beta 2-AR 16 loci in asthmatics: Arg/Arg genotype accounts for 24%, Arg/Gly 45% and Gly/Gly 31%.	Arginine	67-70	adrenoceptor beta 2	Homo sapiens	30-39
11778498-6	2000	(2) The frequency of genotype beta 2-AR 16 loci in asthmatics: Arg/Arg genotype accounts for 24%, Arg/Gly 45% and Gly/Gly 31%.	Arginine	67-70	adrenoceptor beta 2	Homo sapiens	30-39
10620706-2	2000	To rationalize the significant role of the N-terminal sequence Arg(37)-Arg(38) of human TH type 1 (hTH1) in determining the efficiency of feedback inhibition, we produced mutants of which the positively charged Arg(37)-Arg(38) site was replaced by electrically neutral Gly and/or negatively charged Glu and analyzed the degree of inhibition of these mutant enzymes by dopamine.	Arginine	63-66	negative elongation factor complex member C/D	Homo sapiens	99-103
10620706-2	2000	To rationalize the significant role of the N-terminal sequence Arg(37)-Arg(38) of human TH type 1 (hTH1) in determining the efficiency of feedback inhibition, we produced mutants of which the positively charged Arg(37)-Arg(38) site was replaced by electrically neutral Gly and/or negatively charged Glu and analyzed the degree of inhibition of these mutant enzymes by dopamine.	Arginine	71-74	negative elongation factor complex member C/D	Homo sapiens	99-103
10620706-2	2000	To rationalize the significant role of the N-terminal sequence Arg(37)-Arg(38) of human TH type 1 (hTH1) in determining the efficiency of feedback inhibition, we produced mutants of which the positively charged Arg(37)-Arg(38) site was replaced by electrically neutral Gly and/or negatively charged Glu and analyzed the degree of inhibition of these mutant enzymes by dopamine.	Arginine	71-74	negative elongation factor complex member C/D	Homo sapiens	99-103
10620706-2	2000	To rationalize the significant role of the N-terminal sequence Arg(37)-Arg(38) of human TH type 1 (hTH1) in determining the efficiency of feedback inhibition, we produced mutants of which the positively charged Arg(37)-Arg(38) site was replaced by electrically neutral Gly and/or negatively charged Glu and analyzed the degree of inhibition of these mutant enzymes by dopamine.	Arginine	71-74	negative elongation factor complex member C/D	Homo sapiens	99-103
11030087-8	2000	Best activity was shown against hCA I and bCA IV, for which some of the new compounds (such as the Lys, Arg, His or the dipeptide derivatives) showed affinities in the 2-12 nm range (h = human; b = bovine isozymes).	Arginine	104-107	carbonic anhydrase 1	Homo sapiens	32-37
10761688-0	2000	The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: inflammatory mediators and endogenous cholecystokinin.	Arginine	20-30	cholecystokinin	Rattus norvegicus	109-124
10761688-1	2000	This study was aimed at an assessment of the role of oxygen-derived free radicals, cytokines and endogenous cholecystokinin (CCK) in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat.	Arginine	153-163	cholecystokinin	Rattus norvegicus	108-123
10761688-1	2000	This study was aimed at an assessment of the role of oxygen-derived free radicals, cytokines and endogenous cholecystokinin (CCK) in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat.	Arginine	153-163	cholecystokinin	Rattus norvegicus	125-128
10761688-1	2000	This study was aimed at an assessment of the role of oxygen-derived free radicals, cytokines and endogenous cholecystokinin (CCK) in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat.	Arginine	165-168	cholecystokinin	Rattus norvegicus	108-123
10761688-1	2000	This study was aimed at an assessment of the role of oxygen-derived free radicals, cytokines and endogenous cholecystokinin (CCK) in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat.	Arginine	165-168	cholecystokinin	Rattus norvegicus	125-128
10761688-8	2000	The catalase and Mn-SOD activities were significantly decreased throughout the study, while the GPx activity was significantly reduced at 6 and 12 h, and the Cu, Zn-SOD activity was significantly lower at 12 h after the Arg injection as compared with the controls.	Arginine	220-223	superoxide dismutase 2	Rattus norvegicus	17-23
11021404-0	2000	Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N. Carboxypeptidase R (EC 3.4.17.20) (CPR) and carboxypeptidase N (EC 3.4.17.3) (CPN) cleave carboxy-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities.	Arginine	207-215	cytochrome p450 oxidoreductase	Rattus norvegicus	135-138
10617680-3	2000	Apparent K(M) values for transport of L-arginine in both cell types was consistent with the expression of the system y(+) carriers CAT-1 (and CAT-2B in macrophages).	Arginine	38-48	solute carrier family 7 member 1	Homo sapiens	131-136
10630385-0	2000	Arginine induces apoptosis and gene expression of pancreatitis-associated protein (PAP) in rat pancreatic acinar AR4-2J cells.	Arginine	0-8	regenerating family member 3 beta	Rattus norvegicus	50-81
10630385-0	2000	Arginine induces apoptosis and gene expression of pancreatitis-associated protein (PAP) in rat pancreatic acinar AR4-2J cells.	Arginine	0-8	regenerating family member 3 beta	Rattus norvegicus	83-86
10630385-5	2000	PAP messenger RNA (mRNA) was expressed at doses of 2.5 and 5.0 mg/ml of arginine, and a time-course study showed that the expression started 2 h after arginine addition and peaked at 6 h. Apoptosis was rarely seen when PAP mRNA was highly expressed, but occurred when PAP mRNA expression was decreased.	Arginine	72-80	regenerating family member 3 beta	Rattus norvegicus	0-3
10630385-5	2000	PAP messenger RNA (mRNA) was expressed at doses of 2.5 and 5.0 mg/ml of arginine, and a time-course study showed that the expression started 2 h after arginine addition and peaked at 6 h. Apoptosis was rarely seen when PAP mRNA was highly expressed, but occurred when PAP mRNA expression was decreased.	Arginine	151-159	regenerating family member 3 beta	Rattus norvegicus	0-3
10630385-6	2000	These results suggest that arginine induces apoptosis and PAP gene expression in pancreatic acinar cells and that PAP might inhibit the induction of apoptosis.	Arginine	27-35	regenerating family member 3 beta	Rattus norvegicus	58-61
10630412-1	1999	Trypsin digestion of steroid-free, but not steroid-bound, rat glucocorticoid receptor (GR) has recently been reported to occur at arginine-651 (R651).	Arginine	130-138	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	62-85
10630412-1	1999	Trypsin digestion of steroid-free, but not steroid-bound, rat glucocorticoid receptor (GR) has recently been reported to occur at arginine-651 (R651).	Arginine	130-138	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	87-89
10600125-0	1999	Kinetic studies on the successive reaction of neuronal nitric oxide synthase from L-arginine to nitric oxide and L-citrulline.	Arginine	82-92	nitric oxide synthase 1	Rattus norvegicus	46-76
10600125-2	1999	The conversion of L-arginine to N(omega)-hydroxy-L-arginine and further to L-citrulline in one cycle of the reaction of the purified nNOS was measured with the reaction rapid quenching method using (3)H-L-arginine as the substrate.	Arginine	18-28	nitric oxide synthase 1	Rattus norvegicus	133-137
10600125-6	1999	The rate constant for the dissociation of the product L-citrulline from nNOS was calculated from the combination of results of the rapid quenching experiments and the metabolism of L-arginine in the presence of an excess amount of substrate, which was the smallest among all the rate constants in one cycle of the nNOS reaction.	Arginine	181-191	nitric oxide synthase 1	Rattus norvegicus	72-76
10600125-6	1999	The rate constant for the dissociation of the product L-citrulline from nNOS was calculated from the combination of results of the rapid quenching experiments and the metabolism of L-arginine in the presence of an excess amount of substrate, which was the smallest among all the rate constants in one cycle of the nNOS reaction.	Arginine	181-191	nitric oxide synthase 1	Rattus norvegicus	314-318
10661869-5	1999	The Km, k(cat) and k(cat)/Km values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 62.1 s(-1) x nM(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 36.2 s(-1) x nM(-1) for Ala-Arg-MCA, respectively.	Arginine	126-129	dipeptidylpeptidase 3	Rattus norvegicus	39-46
10661869-5	1999	The Km, k(cat) and k(cat)/Km values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 62.1 s(-1) x nM(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 36.2 s(-1) x nM(-1) for Ala-Arg-MCA, respectively.	Arginine	130-133	dipeptidylpeptidase 3	Rattus norvegicus	39-46
10661869-5	1999	The Km, k(cat) and k(cat)/Km values of DPP III at optimal pH (pH 8.5) were 290 microM, 18.0 s(-1) and 62.1 s(-1) x nM(-1) for Arg-Arg-MCA and 125 microM, 4.53 s(-1) and 36.2 s(-1) x nM(-1) for Ala-Arg-MCA, respectively.	Arginine	130-133	dipeptidylpeptidase 3	Rattus norvegicus	39-46
10542253-2	1999	Here, we demonstrate that a previously defined arginine-rich nuclear localization signal (NLS) present in Tap acts exclusively via the transportin import factor.	Arginine	47-55	nuclear RNA export factor 1	Homo sapiens	106-109
10570560-2	1999	We report a case of spontaneous mutation, a C to T transition at codon 162, resulting in an arginine to tryptophan substitution in the 1 A region of the alpha helical rod domain of keratin 9.	Arginine	92-100	keratin 9	Homo sapiens	181-190
10566637-5	1999	In one allele, an undescribed G to C transversion in codon 217, which occurred at the last base of exon 5 and thus altered the splice donor site sequence, apparently resulted in a substitution of Arg to Thr (AGG to ACG: R217T), and in the other allele, a C to T transition in codon 218 caused a substitution of Ala to Val (GCG to GTG: A218V), which has been previously shown to abolish StAR activity.	Arginine	196-199	gamma-glutamyltransferase 1	Homo sapiens	330-333
10521461-3	1999	The data presented here indicate that the arginine-rich domain, when embedded in recombinant fragments of NS3, interacts with the catalytic site of protein kinase C (PKC) and inhibits the phosphorylation mediated by this enzyme in vitro and in vivo.	Arginine	42-50	KRAS proto-oncogene, GTPase	Homo sapiens	106-109
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Arginine	104-112	lipoprotein lipase	Mus musculus	136-139
10510299-8	1999	Competition experiments with positively charged poly(amino acids) furthermore suggested that histidine, arginine and lysine residues in LPL are important for the interaction between LDL and LPL.	Arginine	104-112	lipoprotein lipase	Mus musculus	190-193
10502786-4	1999	Genomic DNA was extracted and denaturinggradient gel electrophoresis of exon 7 of the androgen receptor gene followed by sequence analysis revealed a new mutation, a C A transversion, altering codon 840 from arginine (CGT) to serine (AGT).	Arginine	208-216	UDP glycosyltransferase 8	Homo sapiens	218-221
10497249-13	1999	In contrast, the mutation site of mutant H45A seems to be involved directly in the epimerization process, and the amino acids Asp-413 and Arg-420 of UDP-GlcNAc 2-epimerase/N-acetylmannosamine kinase are essential for the phosphorylation process.	Arginine	138-141	renin binding protein	Rattus norvegicus	153-171
10518318-0	1999	Arginine methylation of a glycine and arginine rich peptide derived from sequences of human FMRP and fibrillarin.	Arginine	0-8	fibrillarin	Homo sapiens	101-112
10467253-1	1999	Nociceptive c-fos expressions in the dorsal horn following intraplantar injection of two kinds of algogenic agents combined with different doses of nitric oxide (NO) synthase inhibitor (N(omega)-nitro-L-arginine methyl ester (L-NAME)) or of NO donor (L-arginine) were used to explore if NO was involved in the activation of peripheral nociceptors.	Arginine	201-211	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	12-17
10471498-7	1999	Co-transfection of bo,+AT and rBAT brings the latter to the plasma membrane, and results in the uptake of L-arginine in COS cells.	Arginine	106-116	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	30-34
10698343-3	1999	Gc-globulin, the transport protein for 25-(OH)-D3, serves selectively as a cochemotactic factor for C5a/Ca(des)Arg.	Arginine	111-114	GC vitamin D binding protein	Homo sapiens	0-11
10455140-4	1999	The structural and functional roles of the arginine residues within these motifs in Glut1 were investigated by expression of site-directed mutant transporters in Xenopus oocytes followed by analyses of intrinsic transport activity and the membrane topology of mutant glycosylation-scanning reporter Glut1 molecules.	Arginine	43-51	solute carrier family 2 (facilitated glucose transporter), member 1 L homeolog	Xenopus laevis	84-89
10469136-10	1999	The tomato LAP-A preferentially hydrolyzed substrates with N-terminal Leu, Met and Arg residues.	Arginine	83-86	leucine aminopeptidase 1, chloroplastic	Solanum lycopersicum	11-16
10465111-4	1999	Activating point mutations in the N-ras gene (nine CAA (Gln) to AAA (Lys) transversions and one CAA (Gln) to CGA (Arg) transition at codon 61) were detected at high frequency (56%).	Arginine	114-117	NRAS proto-oncogene, GTPase	Homo sapiens	34-39
10400673-0	1999	Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.	Arginine	0-8	cholecystokinin A receptor	Homo sapiens	45-71
10400673-3	1999	Here we report on the identification of Arg-336 and Asn-333 of CCK-AR, which interact with the Asp-8 carboxylate and the C-terminal amide of CCK-9, respectively.	Arginine	40-43	cholecystokinin A receptor	Homo sapiens	63-69
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Arginine	111-119	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10381379-0	1999	A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability.	Arginine	77-80	deoxyribonuclease 1	Homo sapiens	14-20
10381379-0	1999	A new allele, DNASE1*6, of human deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability.	Arginine	77-80	deoxyribonuclease 1	Homo sapiens	33-52
10387026-0	1999	The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase.	Arginine	4-12	aldo-keto reductase family 1, member C14	Rattus norvegicus	80-116
10362683-11	1999	These findings suggest that together CAT-1 and CAT-2B play an important role in providing substrate for high-output NO synthesis in vitro as well as in vivo and implicate a coordinated regulation of intracellular iNOS enzyme activity with membrane arginine transport.	Arginine	248-256	solute carrier family 7 member 2	Rattus norvegicus	47-53
10330107-1	1999	Amino acid residues 140-164 of integrin beta1 comprise an Arg-Gly-Asp (RGD) cross-linking region.	Arginine	58-61	integrin subunit beta 1	Homo sapiens	31-45
10325428-1	1999	The Drosophila repressor splicing factor 1 (RSF1) comprises an N-terminal RNA-binding region and a C-terminal domain rich in glycine, arginine and serine residues, termed the GRS domain.	Arginine	134-142	Repressor splicing factor 1	Drosophila melanogaster	15-42
10325428-1	1999	The Drosophila repressor splicing factor 1 (RSF1) comprises an N-terminal RNA-binding region and a C-terminal domain rich in glycine, arginine and serine residues, termed the GRS domain.	Arginine	134-142	Repressor splicing factor 1	Drosophila melanogaster	44-48
10325428-2	1999	Recently, RSF1 has been shown to antagonize splicing factors of the serine/arginine-rich (SR) family and it is, therefore, expected to play a role in processing of a subset of Drosophila pre-mRNAs through specific interactions with RNA.	Arginine	75-83	Repressor splicing factor 1	Drosophila melanogaster	10-14
10411323-6	1999	It is caused by two point mutations in the LH beta-subunit gene, resulting in amino acid alterations: Trp8 --&gt; Arg and Ile15 --&gt; Thr.	Arginine	114-117	luteinizing hormone subunit beta	Homo sapiens	43-50
10329642-6	1999	Although prolonged incubation of the C331A mutant of nNOS with high concentrations of L-arginine results in a catalytically active enzyme, zinc binding is not restored.	Arginine	86-96	nitric oxide synthase 1	Rattus norvegicus	53-57
10229665-7	1999	Alteration of Gly234 to Glu, which is found at the corresponding site in mammalian cathepsin B, increased recombinant LmajcatB (rLmajcatB) activity toward Z-Arg-Arg-AMC 8-fold over the wild-type recombinant enzyme (kcat/Km=3740+/-413 M-1.s-1 versus 472+/-72.4 M-1.s-1).	Arginine	157-160	cathepsin B	Homo sapiens	83-94
10224081-0	1999	Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3.	Arginine	17-25	protein arginine methyltransferase 1	Homo sapiens	132-137
10224081-7	1999	Both PRMT1 and PRMT3 specifically methylated arginines in the C-terminal domain corresponding to the naturally modified sites.	Arginine	45-54	protein arginine methyltransferase 1	Homo sapiens	5-10
10323412-10	1999	The exchange at -47 may alter the expression level of the beta2-adrenergic receptor gene, because the nucleotide substitution at -47 results in a Cys-->Arg exchange at the C terminal of the leader peptide.	Arginine	152-155	adrenoceptor beta 2	Homo sapiens	58-83
10235127-7	1999	These results indicate that preadministered L-arginine protects against water immersion restraint stress-induced gastric mucosal lesions, possibly through restricted NO production by cNOS in gastric mucosal tissues, whereas postadministered L-arginine aggravates the stress-induced gastric mucosal lesions, possibly through excessive NO production by iNOS increasing in gastric mucosal tissues.	Arginine	44-54	nitric oxide synthase 3	Rattus norvegicus	183-187
10191262-9	1999	Like PKB, SGK preferentially phosphorylates serine and threonine residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs, and SGK and PKB inactivate glycogen synthase kinase-3 similarly in vitro and in co-transfection experiments.	Arginine	86-89	serum/glucocorticoid regulated kinase 1	Homo sapiens	10-13
10092643-6	1999	Herein, we investigated this relationship, observing O-2 generation even at saturating levels of L-arginine.	Arginine	97-107	immunoglobulin kappa variable 1D-39	Homo sapiens	53-56
10092643-7	1999	Of interest was the finding that the frequently used NOS inhibitor NG-monomethyl L-arginine enhanced O-2 production in the presence of L-arginine because this antagonist attenuated NO.	Arginine	81-91	immunoglobulin kappa variable 1D-39	Homo sapiens	101-104
10419003-3	1999	In contrast, there is a common polymorphism in the Luteinizing Hormone (LH) beta-subunit gene, where two point mutations cause two alterations in the amino acid sequence (Trp8 --&gt; Arg and Ile15 --&gt; Thr) and introduce an extra glycosylation signal to Asn13.	Arginine	183-186	luteinizing hormone subunit beta	Homo sapiens	51-88
10080937-2	1999	To further characterize the enzymatic properties of CPZ, the enzyme was purified using Arg- and heparin-affinity columns.	Arginine	87-90	carboxypeptidase Z	Homo sapiens	52-55
10080937-5	1999	CPZ cleaves substrates with C-terminal Arg residues, preferring peptides with an Ala in the penultimate position.	Arginine	39-42	carboxypeptidase Z	Homo sapiens	0-3
10085297-1	1999	We recently isolated a novel actin filament (F-actin)-binding protein, afadin, that has two isoforms, l- and s-afadins.	Arginine	102-104	afadin, adherens junction formation factor	Homo sapiens	71-77
10092085-5	1999	We show here that the arginine/serine-rich domain of SWAP and the RNA recognition motifs of SF2 are required for skipping of CD45 exon 4.	Arginine	22-30	serine and arginine rich splicing factor 1	Homo sapiens	92-95
10092085-5	1999	We show here that the arginine/serine-rich domain of SWAP and the RNA recognition motifs of SF2 are required for skipping of CD45 exon 4.	Arginine	22-30	protein tyrosine phosphatase receptor type C	Homo sapiens	125-129
10050048-1	1999	Arginase, which catalyzes the conversion of arginine to urea and ornithine, and consists of a liver-type (arginase I) and a non-hepatic type (arginase II).	Arginine	44-52	arginase 2	Rattus norvegicus	124-153
9873034-2	1999	The N-terminal oxygenase domain (amino acids 1-498; iNOSox) in each subunit binds heme, L-Arg, and tetrahydrobiopterin (H4B), is the site of NO synthesis, and is responsible for the dimeric interaction, which must occur to synthesize NO.	Arginine	88-93	H4 clustered histone 4	Homo sapiens	120-123
9886930-3	1999	In this regard, administration of L-arginine has been shown to restore depressed intestinal and hepatic blood flow after trauma-hemorrhage, probably due to provision of substrate for constitutive nitric oxide synthase (cNOS).	Arginine	34-44	nitric oxide synthase 3	Rattus norvegicus	219-223
9876119-7	1999	Positively charged surface regions of aldolase (residues Lys 13, 27, 288, 293, and 341 and Arg 257) are attracted to the negatively charged amino terminus (Asp 1 and Glu 2 and 4) and other patches (Asp 24, 25, and 363 and Glu 361, 364, 99, and 100) of actin subunits.	Arginine	91-94	beta-secretase 2	Homo sapiens	156-161
10071480-0	1999	L-arginine stimulates NO-dependent vasodilation in healthy humans--effect of somatostatin pretreatment.	Arginine	0-10	somatostatin	Homo sapiens	77-89
9930939-3	1999	A similar posttransplant reduction to approximately 25% of the insulin secretory capacity as assessed by intravenous arginine stimulation during 35 mM glucose clamps, mirrored the reduction of the islet mass.	Arginine	117-125	insulin	Canis lupus familiaris	63-70
9878114-1	1998	CD44 contains two clustered basic residues of three arginines and three lysines in the membrane-proximal region of its cytoplasmic domain.	Arginine	52-61	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9878114-11	1998	These results provide evidence that both the arginine and the lysine motifs are important in the binding of CD44 to high levels of HA when stimulated with PMA.	Arginine	45-53	CD44 molecule (Indian blood group)	Homo sapiens	108-112
9836577-6	1998	One such difference implies that NT-3"s binding affinity and specificity depend on a novel hydrogen bond between Gln 83, a residue important for binding specificity with TrkC, and Arg 103, a residue crucial for binding affinity with TrkC.	Arginine	180-183	neurotrophin 3	Homo sapiens	33-37
9836577-6	1998	One such difference implies that NT-3"s binding affinity and specificity depend on a novel hydrogen bond between Gln 83, a residue important for binding specificity with TrkC, and Arg 103, a residue crucial for binding affinity with TrkC.	Arginine	180-183	neurotrophic receptor tyrosine kinase 3	Homo sapiens	233-237
10221600-5	1998	These results demonstrate that CPE is required for the correct processing of arginine- and glycine-extended CCK in all major regions of the mouse brain.	Arginine	77-85	carboxypeptidase E	Mus musculus	31-34
10221600-5	1998	These results demonstrate that CPE is required for the correct processing of arginine- and glycine-extended CCK in all major regions of the mouse brain.	Arginine	77-85	cholecystokinin	Mus musculus	108-111
9835617-8	1998	In human airway smooth muscle cells that natively express beta2AR, receptor expression was approximately twofold higher in those bearing the Cys versus the Arg polymorphism, confirming the phenotype in a relevant cell type.	Arginine	156-159	adrenoceptor beta 2	Homo sapiens	58-65
9828110-3	1998	The C-terminal domains of Arg and c-abl, poorly similar to each other, may account for their different functions.	Arginine	26-29	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	34-39
9806906-8	1998	Mutation of Glu, Asp or Arg at positions -4, -1 or +1 respectively relative to Tyr1003 in a 9-mer peptide (residues 999-1007) abolished the ability of the peptide to decrease the PTP activity associated with Met.	Arginine	24-27	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	179-182
9804899-2	1998	The majority of L-arginine flux is mediated by transport system y+ that is encoded by at least three genes, Cat1, Cat2 and Cat3.	Arginine	16-26	solute carrier family 7 member 1	Homo sapiens	108-112
9804899-2	1998	The majority of L-arginine flux is mediated by transport system y+ that is encoded by at least three genes, Cat1, Cat2 and Cat3.	Arginine	16-26	solute carrier family 7 member 3	Homo sapiens	123-127
9833037-8	1998	The same arginine position has been mutated in the keratin 10 gene in epidermolytic hyperkeratosis, the keratin 14 gene in epidermolysis bullosa simplex, and the keratin 9 gene in hereditary EPPK in Western patients.	Arginine	9-17	keratin 9	Homo sapiens	162-171
9833603-11	1998	L-arginine (30 g) also significantly increased urinary nitrate and cyclic GMP excretion rates by 97+/-28 and 66+/-20%, respectively.	Arginine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	74-77
9833603-12	1998	After infusion of 6 g L-arginine, urinary nitrate excretion also significantly increased, (nitrate by 47+/-12% [P&lt;0.05], cyclic GMP by 67+/-47% [P= ns]), although to a lesser and more variable extent than after 30 g of L-arginine.	Arginine	22-32	5'-nucleotidase, cytosolic II	Homo sapiens	131-134
9924333-7	1998	Each proband had a homozygous G--&gt;A transition at codon 124, replacing Arg--&gt;His, of the keratoepithelin gene.	Arginine	74-77	transforming growth factor beta induced	Homo sapiens	95-110
11189233-7	1998	The point mutation from CGT (Arg) to TGT (Cys) at codon 201 was detected in 21 pituitary tumors, but the point mutation from CAG (Gln) to CTG (Leu) at codon 227 of the Gs alpha gene was found in only 1 tumor.	Arginine	29-32	UDP glycosyltransferase 8	Homo sapiens	24-27
9874001-0	1998	Immunohistochemical localization of arginase II and other enzymes of arginine metabolism in rat kidney and liver.	Arginine	69-77	arginase 2	Rattus norvegicus	36-47
9798984-4	1998	Mod alpha2AP was prepared by treating native alpha2AP with an Arg-specific reagent, phenylglyoxal.	Arginine	62-65	serpin family F member 2	Homo sapiens	4-12
9798984-5	1998	An average of four of the total nineteen Arg residues in alpha2AP reacted with phenylglyoxal and resulted in complete loss of plasmin inhibitory activity; however, mod alpha2AP competed effectively with native alpha2AP for becoming crosslinked to fibrin by FXIIIa catalysis.	Arginine	41-44	serpin family F member 2	Homo sapiens	57-65
9729461-4	1998	Here we report the effect on the reduction of two ketone and two aldehyde substrates by pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase in which tyrosine-194 has been mutated to phenylalanine and cysteine, and lysine-198 has been mutated to isoleucine and arginine.	Arginine	260-268	carbonyl reductase [NADPH] 1	Sus scrofa	92-139
9737862-1	1998	Alignment of xenobiotic-metabolizing P450 protein sequences highlights an invariant proline residue in the meander region two amino acids N-terminal to the distal arginine of the putative ERR triad thought to be important for heme binding.	Arginine	163-171	solute carrier family 7 member 1	Homo sapiens	188-191
9724550-0	1998	Arginine-42 and threonine-45 are required for FAD incorporation and catalytic activity in human monoamine oxidase B.	Arginine	0-8	monoamine oxidase B	Homo sapiens	96-115
9724716-7	1998	To disrupt the RI-RNase A interaction, three RNase A residues (Asp-38, Gly-88, and Ala-109) that form multiple contacts with RI were replaced with arginine.	Arginine	147-155	ribonuclease/angiogenin inhibitor 1	Bos taurus	15-17
9708487-6	1998	In rats with LVH L-arginine treatment led to a 35% increase in cNOS protein levels (p = 0.09 vs untreated animals with LVH) and a 1.7-fold increase in LV cyclic GMP levels (p &lt; 0.05 vs untreated animals with LVH).	Arginine	17-27	nitric oxide synthase 3	Rattus norvegicus	63-67
9706164-2	1998	Because endothelial cell dysfunction is characterized by the reduced release of nitric oxide (NO) by endothelial constitutive NO synthase (cNOS), we tested the hypothesis that administration of L-arginine (ie, the substrate for cNOS) after trauma and hemorrhage should have beneficial effects on depressed cardiac output and organ blood flow under those conditions.	Arginine	194-204	nitric oxide synthase 3	Rattus norvegicus	139-143
9706164-2	1998	Because endothelial cell dysfunction is characterized by the reduced release of nitric oxide (NO) by endothelial constitutive NO synthase (cNOS), we tested the hypothesis that administration of L-arginine (ie, the substrate for cNOS) after trauma and hemorrhage should have beneficial effects on depressed cardiac output and organ blood flow under those conditions.	Arginine	194-204	nitric oxide synthase 3	Rattus norvegicus	228-232
9657977-1	1998	It has been shown that one arginine per monomer at an unknown position is essential for enzyme activity of the homodimeric transketolase (TK) [Kremer, Egan and Sable (1980) J. Biol.	Arginine	27-35	transketolase	Rattus norvegicus	123-136
9657977-4	1998	To identify the critical arginine, four highly conserved arginine residues of rat TK (Arg102, Arg350, Arg433 and Arg506) were replaced with alanine by site-directed mutagenesis.	Arginine	25-33	transketolase	Rattus norvegicus	82-84
9657977-4	1998	To identify the critical arginine, four highly conserved arginine residues of rat TK (Arg102, Arg350, Arg433 and Arg506) were replaced with alanine by site-directed mutagenesis.	Arginine	57-65	transketolase	Rattus norvegicus	82-84
9712231-7	1998	CONCLUSIONS: Parenteral LPS, similarly to the chemical NO donor, SNAP, protects the gastric mucosa against ethanol-induced damage via an increase in GBF mediated by NO due to the activation of arginine-NO system and possibly also enhanced generation of PGE2.	Arginine	193-201	Kruppel like factor 6	Homo sapiens	149-152
9632678-5	1998	In addition, we have replaced the conserved arginine (Arg305), which was suggested by structural studies to be a key catalytic residue, with an alanine and found that the R305A Cdc42-GAP mutant has a greatly diminished catalytic capacity but is still able to bind Cdc42 with high affinity.	Arginine	44-52	Rho GTPase activating protein 1	Homo sapiens	177-186
9632690-3	1998	Consistently, mutations on the charged surface of the groove (Lys-49, Arg-56, and Arg-60) decrease the binding of 14-3-3zeta to the ligands tested (Zhang, L., Wang, H., Liu, D., Liddington, R., and Fu, H. (1997) J. Biol.	Arginine	70-73	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	114-124
9632690-3	1998	Consistently, mutations on the charged surface of the groove (Lys-49, Arg-56, and Arg-60) decrease the binding of 14-3-3zeta to the ligands tested (Zhang, L., Wang, H., Liu, D., Liddington, R., and Fu, H. (1997) J. Biol.	Arginine	82-85	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	114-124
9625728-2	1998	The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased at a more positive one-electron reduction potential, suggesting that quinone appears to act as an electron acceptor for nNOS.	Arginine	44-54	nitric oxide synthase 1	Rattus norvegicus	286-290
9565624-3	1998	The MCAT-1 receptor is also a cationic amino acid transporter, and the HuH-7.MCAT-1.7 cells showed increased Vmax of uptake and steady-state accumulation of the cationic amino acids L-arginine and L-lysine.	Arginine	182-192	MIR7-3 host gene	Homo sapiens	71-76
9565624-4	1998	In HuH-7.MCAT-1 cells, L-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased L-arginine uptake along with cellular DNA synthesis.	Arginine	23-33	MIR7-3 host gene	Homo sapiens	3-8
9565624-4	1998	In HuH-7.MCAT-1 cells, L-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased L-arginine uptake along with cellular DNA synthesis.	Arginine	153-163	MIR7-3 host gene	Homo sapiens	3-8
9593136-7	1998	After cloning of the gene, analysis of the complete nucleotide sequence (1,146 bp) showed that this ampC gene is close to blaCMY-2, from which it differs by three point mutations leading to amino acid substitutions Glu --&gt; Gly at position 22, Trp --&gt; Arg at position 201, and Ser --&gt; Asn at position 343.	Arginine	257-260	AmpC	Proteus mirabilis	122-130
9709410-0	1998	The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.	Arginine	4-14	chromosome 20 open reading frame 181	Homo sapiens	72-100
9709410-7	1998	CONCLUSIONS: The L-arginine/nitric oxide pathway contributes to substance P-induced t-PA release in vivo in man.	Arginine	17-27	chromosome 20 open reading frame 181	Homo sapiens	84-88
9521697-1	1998	The oxygenase domain (amino acids 1-498) of inducible nitric oxide synthase (iNOSox) is a hemeprotein that binds L-arginine (L-Arg) and tetrahydrobiopterin (H4B).	Arginine	113-123	H4 clustered histone 4	Homo sapiens	157-160
9521697-1	1998	The oxygenase domain (amino acids 1-498) of inducible nitric oxide synthase (iNOSox) is a hemeprotein that binds L-arginine (L-Arg) and tetrahydrobiopterin (H4B).	Arginine	125-130	H4 clustered histone 4	Homo sapiens	157-160
9494104-10	1998	Both the Yap3 and Mkc7 proteases preferred to cleave at a single Glu-Lys downward arrow-Glu-Arg site.	Arginine	92-95	aspartyl protease	Saccharomyces cerevisiae S288C	18-22
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Arginine	115-118	transforming growth factor beta induced	Homo sapiens	223-233
9502416-8	1998	Amino-terminal sequence analysis of the protein revealed a Gly-Pro-Ala-Lys-Ser-Pro-Tyr-Gln-Leu-Val-Leu-Gln-His-Ser-Arg sequence indistinguishable from an amino-terminal protein sequence deduced from a cDNA clone designated beta ig-h3, and it as well as the abnormal accumulations in GCD cross-reacted with beta ig-h3 antiserum.	Arginine	115-118	transforming growth factor beta induced	Homo sapiens	306-316
9499091-3	1998	Translation of RNAs in reticulocyte lysates showed that cleavage at the nsP3/nsP4 site occurred efficiently for all mutants except for Glu-nsP4, which was cleaved inefficiently, and Pro-nsP4, which was not detectably cleaved, and that Tyr, Cys, Leu, Arg, and Phe destabilized nsP4 but Ala, Met, Thr, Asn, Gln, and Glu stabilized nsP4 to various extents.	Arginine	250-253	SH2 domain containing 3C	Homo sapiens	72-76
9468476-4	1998	Substitutions Thr178 --&gt; Ser, Ile181 --&gt; Phe, and Lys205 --&gt; Arg of Gtalpha did not alter its interaction with hRGSr.	Arginine	70-73	integrin subunit alpha 2b	Homo sapiens	77-84
9527396-9	1998	Supplementation of L-arginine intake increased the release of glomerular nitrite and reduced glomerular RANTES expression after the injection of LPS.	Arginine	19-29	C-C motif chemokine ligand 5	Rattus norvegicus	104-110
9527396-10	1998	Inhibition of the L-arginine/NO pathway by the unspecific NO synthase inhibitor N(G)-nitro-L-arginine methylester significantly increased glomerular RANTES mRNA expression and the number of infiltrating glomerular macrophages.	Arginine	18-28	C-C motif chemokine ligand 5	Rattus norvegicus	149-155
9527396-10	1998	Inhibition of the L-arginine/NO pathway by the unspecific NO synthase inhibitor N(G)-nitro-L-arginine methylester significantly increased glomerular RANTES mRNA expression and the number of infiltrating glomerular macrophages.	Arginine	20-28	C-C motif chemokine ligand 5	Rattus norvegicus	149-155
9527396-11	1998	These data demonstrate that L-arginine suppresses glomerular RANTES formation and suggest that the chemokine-mediated recruitment of glomerular macrophages in LPS-induced endotoxemia can be modulated by the L-arginine/NO pathway.	Arginine	28-38	C-C motif chemokine ligand 5	Rattus norvegicus	61-67
9454596-2	1998	The minimal inhibitory sequence is a tripeptide, L-tyrosinyl-L-isoleucyl-L-arginyl, which competitively inhibits the hydrolysis of small chromogenic substrates by factor Xa but binds in an orientation which prevents a productive nucleophilic attack by serine 195 of the catalytic triad on the carbonyl carbon of the carboxyterminal arginine.	Arginine	332-340	coagulation factor X	Homo sapiens	163-172
9425086-15	1998	In addition, 14-3-3 zeta bound with lower affinity to a peptide based on the central region of the GP Ibalpha cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibbeta (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 zeta with comparable affinity to the GHSL-containing peptide.	Arginine	130-133	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	13-24
9425086-15	1998	In addition, 14-3-3 zeta bound with lower affinity to a peptide based on the central region of the GP Ibalpha cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibbeta (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 zeta with comparable affinity to the GHSL-containing peptide.	Arginine	130-133	glycoprotein Ib platelet subunit alpha	Homo sapiens	99-109
9425086-15	1998	In addition, 14-3-3 zeta bound with lower affinity to a peptide based on the central region of the GP Ibalpha cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibbeta (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 zeta with comparable affinity to the GHSL-containing peptide.	Arginine	219-222	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	13-24
9425086-15	1998	In addition, 14-3-3 zeta bound with lower affinity to a peptide based on the central region of the GP Ibalpha cytoplasmic domain (Arg-557-Gly-575), whereas peptide sequences within the cytoplasmic domains of GP Ibbeta (Arg-160-Arg-175) and GP V (Lys-529-Gly-544) bound 14-3-3 zeta with comparable affinity to the GHSL-containing peptide.	Arginine	219-222	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	13-24
9872509-16	1998	Addition to L-NAME of L-arginine, but not D-arginine, restored the protective and hyperemic effects of CCK-8 and duodenal oleate against gastric lesions induced by ethanol or acidified ASA.	Arginine	22-32	cholecystokinin	Rattus norvegicus	103-106
9686345-1	1998	Nitric oxide (NO) is synthesized from arginine by nitric-oxide synthase (NOS), and citrulline that is generated can be recycled to arginine by argininosuccinate synthase (AS) and argininosuccinate lyase (AL).	Arginine	131-139	argininosuccinate synthase 1	Rattus norvegicus	143-169
9972053-6	1998	CCK administered with L-Arg evoked hypotension (opposite to the hypertensive effect evoked by CCK).	Arginine	22-27	cholecystokinin	Rattus norvegicus	0-3
9972053-15	1998	L-Arg abolished and when we used with CCK in the highest dose reversed the positive inotropic effect of the peptide and tendent to abolish a lowered coronary outflow evoked by CCK.	Arginine	0-5	cholecystokinin	Rattus norvegicus	176-179
9395513-2	1997	Cleavage within cells is mediated by furin, occurs between arginine 279 and glycine 280, and requires an arginine at both P1 and P4 residues.	Arginine	105-113	crystallin gamma F, pseudogene	Homo sapiens	122-131
9428669-1	1997	We have cloned by functional complementation and characterized the yeast ARG7 gene encoding mitochondrial ornithine acetyltransferase, the enzyme catalyzing the fifth step in arginine biosynthesis.	Arginine	175-183	glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	73-77
9428669-3	1997	Interestingly, total deletion of the genomic ARG7 ORF resulted in an arginine-leaky phenotype, indicating that yeast cells possess an alternative route for generating ornithine from acetylornithine.	Arginine	69-77	glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	45-49
9428669-13	1997	As with several bacterial ornithine acetyltransferases, the activity of Arg7p was practically insensitive to arginine but strongly inhibited by ornithine, which behaved as a competitive inhibitor.	Arginine	109-117	glutamate N-acetyltransferase	Saccharomyces cerevisiae S288C	72-77
9412818-6	1997	Sequence analysis revealed a G-to-A transition at nucleotide 6127 in the triple-helical domain of COL7A1, which converted a glycine residue at amino acid position 2043 to an arginine.	Arginine	174-182	collagen type VII alpha 1 chain	Homo sapiens	98-104
9401045-8	1997	Definition of this oruR locus and its effects upon OAcT activity provide evidence that control of ornithine levels in P. aeruginosa may have a significant impact upon how the cell is able to monitor and regulate the use of arginine and glutamate as sources of either carbon or nitrogen.	Arginine	223-231	ornithine utilization transcriptional regulator OruR	Pseudomonas aeruginosa PAO1	19-23
9375674-1	1997	Agmatine (decarboxylated arginine), an endogenous ligand for imidazoline receptors, has been identified in brain where it is synthesized from arginine by arginine decarboxylase.	Arginine	25-33	antizyme inhibitor 2	Rattus norvegicus	154-176
9375674-1	1997	Agmatine (decarboxylated arginine), an endogenous ligand for imidazoline receptors, has been identified in brain where it is synthesized from arginine by arginine decarboxylase.	Arginine	142-150	antizyme inhibitor 2	Rattus norvegicus	154-176
9371600-10	1997	There are four Arg residues in the QRRGRTGR motif of the HCV NS3 protein, and the second, Arg1488, was important for RNA binding and enzyme activity, even though it is less well conserved than other Arg residues.	Arginine	15-18	KRAS proto-oncogene, GTPase	Homo sapiens	61-64
9371600-10	1997	There are four Arg residues in the QRRGRTGR motif of the HCV NS3 protein, and the second, Arg1488, was important for RNA binding and enzyme activity, even though it is less well conserved than other Arg residues.	Arginine	90-93	KRAS proto-oncogene, GTPase	Homo sapiens	61-64
9428662-4	1997	Factor Xa was found to cleave APP after arginines 102, 268, 510, 573 and 601 (APP695 numeration); most of these sites appear to be common for different coagulation factors.	Arginine	40-49	coagulation factor X	Homo sapiens	0-9
9464869-9	1997	Plasma C3a des Arg levels arose to 2037 +/- 120 ng/ml, 1216 + 434 ng/ml and 46 +/- 55 ng/ml with acetate-, benzyl-cellulose and polysulfone, respectively.	Arginine	15-18	complement C3	Homo sapiens	7-10
9360557-9	1997	This point mutation determined the substitution of a stop codon (TGA) for arginine (CGA) at amino acid position 30 at the first zinc finger of the DNA-binding domain of the VDR.	Arginine	74-82	vitamin D receptor	Homo sapiens	173-176
9312154-2	1997	Nop4p is unusual in that it contains four RNA recognition motifs (RRMs) including one noncanonical RRM, as well as several auxiliary motifs, two acidic regions between the RRMs, and a carboxyl-terminal domain rich in lysines and arginines.	Arginine	229-238	mRNA-binding ribosome biosynthesis protein NOP4	Saccharomyces cerevisiae S288C	0-5
9341936-6	1997	High numbers of ArG were observed in the anterior part of the CA1 subfield in all cases.	Arginine	16-19	carbonic anhydrase 1	Homo sapiens	62-65
9307219-9	1997	The mean time-averaged concentrations of C3a(des Arg) over 150 min were 1168 ng ml(-1) (SMC), 1030 ng ml(-1) (cellulose acetate), 1297 ng ml(-1) (Cuprophan) and 790 ng ml(-1) (low-flux polysulphone).	Arginine	49-52	complement C3	Homo sapiens	41-44
9298990-7	1997	Consistent with this model, mutation of arginine 118 (R118) in MAG to either alanine or aspartate abolishes its sialic acid-dependent binding.	Arginine	40-48	myelin associated glycoprotein	Homo sapiens	63-66
9275097-3	1997	In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue.	Arginine	57-60	cholecystokinin	Mus musculus	45-48
9275097-3	1997	In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue.	Arginine	57-60	carboxypeptidase E	Mus musculus	62-65
9275097-3	1997	In contrast, using an antiserum specific for CCK Gly Arg Arg, Cpe(fat)/Cpe(fat) mice brain had about 13-fold higher levels of this peptide relative to controls, while levels were identical in mutant and control duodenal tissue.	Arginine	57-60	carboxypeptidase E	Mus musculus	71-74
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	20-23
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	carboxypeptidase E	Mus musculus	39-42
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	carboxypeptidase E	Mus musculus	48-51
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	28-31	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	20-23
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	39-42
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	48-51
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	20-23
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	39-42
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	48-51
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	20-23
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	39-42
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	carboxypeptidase E	Mus musculus	48-51
9275097-5	1997	The accumulation of CCK Gly Arg Arg in Cpe(fat)/Cpe(fat) brains provides definitive proof that the dibasic cleavage of the carboxyl terminus of pro CCK occurs on the carboxyl terminal of the dibasic, between the Arg and Ser as well as confirming that amidated CCK 8 in brain originates from CCK 8 Gly Arg Arg rather than from larger amidated peptides like CCK 22 or CCK 33.	Arginine	32-35	cholecystokinin	Mus musculus	148-151
9262406-7	1997	Arg 85 of rhoGAP interacts with the P-loop of Cdc42Hs, but from biochemical data and by analogy with the G-protein subunit G(i alpha1), we propose that it adopts a different conformation during the catalytic cycle which enables it to stabilize the transition state of the GTP-hydrolysis reaction.	Arginine	0-3	Rho GTPase activating protein 1	Homo sapiens	10-16
9264504-14	1997	Northern analysis using full-length MCP-1 cDNA demonstrated increased expression in Chol and LNA aortas; this expression was decreased in aortas from Arg animals.	Arginine	150-153	C-C motif chemokine 2	Oryctolagus cuniculus	36-41
9228069-8	1997	The SH2 and kinase domain of Arg are 95% identical to that of c-Abl.	Arginine	29-32	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	62-67
9220985-0	1997	Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity.	Arginine	13-22	prothrombin	Oryctolagus cuniculus	42-50
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	prothrombin	Oryctolagus cuniculus	59-67
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Arginine	18-21	prothrombin	Oryctolagus cuniculus	69-77
9240466-2	1997	Here we show that the glutamine at position 235 and arginine at the position 272 in the hMC5R are contributing to the low affinity of this receptor.	Arginine	52-60	melanocortin 5 receptor	Homo sapiens	88-93
9211900-0	1997	ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks.	Arginine	0-3	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	103-108
9211900-4	1997	ArgBP2 associates with and is a substrate of Arg and v-Abl, and is phosphorylated on tyrosine in v-Abl-transformed cells.	Arginine	0-3	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	53-58
9211900-4	1997	ArgBP2 associates with and is a substrate of Arg and v-Abl, and is phosphorylated on tyrosine in v-Abl-transformed cells.	Arginine	0-3	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	97-102
9233561-7	1997	The 467(Pro-->Arg) substitution responsible for G6PD Neapolis is discussed in the light of the current 3D model of human G6PD and in comparison with other natural mutations which occur in the proximity of residue 467.	Arginine	14-17	glucose-6-phosphate dehydrogenase	Homo sapiens	48-52
9233561-7	1997	The 467(Pro-->Arg) substitution responsible for G6PD Neapolis is discussed in the light of the current 3D model of human G6PD and in comparison with other natural mutations which occur in the proximity of residue 467.	Arginine	14-17	glucose-6-phosphate dehydrogenase	Homo sapiens	121-125
9202057-5	1997	A series of peptides surrounding a plasmin cleavage site (arginine 361) near the carboxy-terminal end of vitronectin were synthesized.	Arginine	58-66	vitronectin	Homo sapiens	105-116
9195976-2	1997	With constitutively expressed argininosuccinate lyase (AL), AS confers cells with an Arg/Cit cycle that can sustain NO production via continuous regeneration of the NOS substrate, L-arginine (Arg), from the NOS coproduct, L-citrulline (Cit).	Arginine	85-88	argininosuccinate lyase	Homo sapiens	30-53
9195976-2	1997	With constitutively expressed argininosuccinate lyase (AL), AS confers cells with an Arg/Cit cycle that can sustain NO production via continuous regeneration of the NOS substrate, L-arginine (Arg), from the NOS coproduct, L-citrulline (Cit).	Arginine	180-190	argininosuccinate lyase	Homo sapiens	30-53
9195976-2	1997	With constitutively expressed argininosuccinate lyase (AL), AS confers cells with an Arg/Cit cycle that can sustain NO production via continuous regeneration of the NOS substrate, L-arginine (Arg), from the NOS coproduct, L-citrulline (Cit).	Arginine	192-195	argininosuccinate lyase	Homo sapiens	30-53
9208936-2	1997	We have previously reported the affinity purification of hK2 heterologously expressed in a hamster cell line and demonstrated an arginine-restricted substrate specificity.	Arginine	129-137	RBPJ pseudogene 3	Homo sapiens	57-60
9187667-7	1997	Six out of nine nucleotide substitutions in the Cx32 gene involved two codons encoding arginine at positions 164 and 183, suggesting that these two codons may constitute two Cx32 regions prone to mutate in the Spanish population.	Arginine	87-95	gap junction protein beta 1	Homo sapiens	48-52
9187667-7	1997	Six out of nine nucleotide substitutions in the Cx32 gene involved two codons encoding arginine at positions 164 and 183, suggesting that these two codons may constitute two Cx32 regions prone to mutate in the Spanish population.	Arginine	87-95	gap junction protein beta 1	Homo sapiens	174-178
9210463-4	1997	Moreover, the RNA-binding, anti-terminator N proteins of lambda, phi21 and P22 phages show sequence similarities with HIV Nef at the Arg-rich motif.	Arginine	133-136	Nef	Human immunodeficiency virus 1	122-125
9210463-6	1997	The N-terminal 35 amino acids of HIV-1 Nef that comprise the Arg-rich motif are sufficient for RNA binding.	Arginine	61-64	Nef	Human immunodeficiency virus 1	39-42
9210463-7	1997	Point mutations engineered at the Arg-rich motif of HIV-1 Nef revealed that basic amino acid residues are essential for RNA-binding activity.	Arginine	34-37	Nef	Human immunodeficiency virus 1	58-61
9144164-10	1997	Mutation of a conserved arginine within the basic regions of Fos and transversion of the central C:G base pair in the AP-1 site to G:C had complementary effects on the orientation of heterodimer binding and DNA bending.	Arginine	24-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
9144190-3	1997	Truncation of the terminal carboxyl-tail to eight amino acids or mutation of the highly conserved aspartate-arginine-tyrosine, or DRY, sequence in the second cytoplasmic loop of CCR5 effectively blocked chemokine-dependent activation of classic second messengers, intracellular calcium fluxes, and the cellular response of chemotaxis.	Arginine	108-116	C-C motif chemokine receptor 5	Homo sapiens	178-182
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Arginine	188-196	CCT	Homo sapiens	179-182
9141561-3	1997	DNA was extracted, the insulin gene amplified by the PCR, and by direct sequencing, a novel point mutation, G1552C, was identified, which resulted in the substitution of proline (CCT) for arginine (CGT) at position 65.	Arginine	188-196	UDP glycosyltransferase 8	Homo sapiens	198-201
9092503-9	1997	This suggests that mammalian Kex2-like serine proteases may process pro-CCK at single arginine residues.	Arginine	86-94	kexin KEX2	Saccharomyces cerevisiae S288C	29-33
9112013-0	1997	Mechanisms of arginine-induced increase in cytosolic calcium concentration in the beta-cell line NIT-1.	Arginine	14-22	nitrilase 1	Mus musculus	97-102
9112013-8	1997	It can be concluded that the arginine-induced increase in cytosolic calcium concentration in NIT-1 cells is attributable to an electrogenic effect following the transport of arginine leading to depolarisation of the plasma membrane potential, although metabolism of the amino acid itself may also partially contribute to the response.	Arginine	29-37	nitrilase 1	Mus musculus	93-98
9112013-8	1997	It can be concluded that the arginine-induced increase in cytosolic calcium concentration in NIT-1 cells is attributable to an electrogenic effect following the transport of arginine leading to depolarisation of the plasma membrane potential, although metabolism of the amino acid itself may also partially contribute to the response.	Arginine	174-182	nitrilase 1	Mus musculus	93-98
9098069-4	1997	Downstream from the arg cluster, two open reading frames (ORF7 and ORF8) having unknown functions were found.	Arginine	20-23	hypothetical protein	Lactobacillus plantarum	67-71
9163534-1	1997	The phosphorylation site(s) involved in the activation of CaM-kinase IV by CaM-kinase kinase alpha was studied using a mutant CaM-kinase IV (K71R) in which Lys71 (ATP-binding site) was replaced with Arg, because the autophosphorylation of CaM-kinase IV occurring at multiple sites made it difficult to study phosphorylation of the enzyme by CaM-kinase kinase.	Arginine	199-202	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	75-98
9126751-8	1997	An adhesion assay with extracellular matrix proteins demonstrated that C1300 NB cells adhered preferentially to vitronectin and fibronectin, and the adherence was strongly inhibited by Arg-Gly-Asp (RGD)-containing peptides.	Arginine	185-188	vitronectin	Mus musculus	112-123
9126601-5	1997	Also, our preparation demonstrated expected biological properties of OPN including adhesion of both endothelial and vascular smooth muscle cells to OPN in a dose- and Arg-Gly-Asp-dependent manner.	Arginine	167-170	secreted phosphoprotein 1	Bos taurus	69-72
9126601-5	1997	Also, our preparation demonstrated expected biological properties of OPN including adhesion of both endothelial and vascular smooth muscle cells to OPN in a dose- and Arg-Gly-Asp-dependent manner.	Arginine	167-170	secreted phosphoprotein 1	Bos taurus	148-151
9079642-9	1997	Using site-directed mutagenesis we demonstrate that an arginine at position 304 of the hE2 protein is responsible for the recognition of specific base pairs at this position.	Arginine	55-63	cystatin 12, pseudogene	Homo sapiens	87-90
9136983-3	1997	A remarkably conserved mutation (Gly 380--&gt;Arg) in the transmembrane region of FGFR-3 has been shown to be responsible for achondroplasia (ACH) but it was not clear whether such mutations result in loss of receptor function or constitutive activation.	Arginine	46-49	fibroblast growth factor receptor 3	Homo sapiens	82-88
9124567-7	1997	Compared with control, cortisol administration increased 1) the activities of ASL and arginase and the production of CO(2), ornithine, and proline from arginine, and 2) P5C synthase activity and the formation of glutamate, alanine, aspartate, ornithine, citrulline, proline, and CO(2) from glutamine in enterocytes.	Arginine	152-160	argininosuccinate lyase	Sus scrofa	78-81
9054935-6	1997	All detected mutations occurred at the CpG dinucleotide of two arginine codons: R555W in one CDGG1, R555Q in one CDRB, R124C in two CDL1 and R124H in two ACD families.	Arginine	63-71	transforming growth factor beta induced	Homo sapiens	93-98
9030577-6	1997	These results were complemented by labeling vitronectin with an arginine-specific coumarin probe which compromises heparin binding but does not interfere with PAI-1 binding to the protein.	Arginine	64-72	vitronectin	Homo sapiens	44-55
9024155-7	1997	Expression of ICAM-1 was reduced with both concentrations of L-arginine compared with control in both the basal (43 +/- 12%, P &lt; .01), and stimulated (46 +/- 15%, P &lt; .01) states, which correlated with decreased levels of mRNA.	Arginine	61-71	intercellular adhesion molecule 1	Homo sapiens	14-20
9008461-0	1997	L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice.	Arginine	0-10	low density lipoprotein receptor	Mus musculus	73-85
9008461-12	1997	CONCLUSIONS: The data indicate that L-arginine prevents xanthoma formation and reduces atherosclerosis in LDL receptor knockout mice fed a high-cholesterol diet.	Arginine	36-46	low density lipoprotein receptor	Mus musculus	106-118
8999826-5	1997	Arg-111 and Arg-132 of CRABP-II were replaced with methionine by site-directed mutagenesis.	Arginine	12-15	cellular retinoic acid binding protein 2	Homo sapiens	23-31
9010216-5	1997	PACT contains a serine/arginine (SR) rich region and a C" terminal lysine rich domain.	Arginine	23-31	RB binding protein 6, ubiquitin ligase	Homo sapiens	0-4
8990170-3	1997	RBP1 belongs to the Ser-Arg-rich (SR) protein family of splicing factors, which have in common a N-terminal RNA recognition motif-type RNA binding domain, a Gly-rich region, and a C-terminal SR domain.	Arginine	24-27	RNA-binding protein 1	Drosophila melanogaster	0-4
9020386-5	1997	Recently a mutational thymidine (T)--&gt;guanosine (G) transversion in isoform 1 of the PMCA has been identified resulting in the substitution of a methionine (Met) by an arginine (Arg) at amino acid position 267 in a highly conserved domain of the pump molecule.	Arginine	181-184	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	88-92
8978749-3	1997	The potentiation effect of arginine on carbachol-induced calcium mobilization was mimicked by either 8-bromo cyclic GMP or sodium nitroprusside.	Arginine	27-35	5'-nucleotidase, cytosolic II	Homo sapiens	116-119
8978749-4	1997	In addition, it was found that arginine induced NO production and an increase in cyclic GMP.	Arginine	31-39	5'-nucleotidase, cytosolic II	Homo sapiens	88-91
8978749-5	1997	Moreover, arginine-induced potentiation, NO production, and cyclic GMP increases were all suppressed after the preincubation of cells with N-methyl-L-arginine or N-nitro-L-arginine, nitric oxide synthase inhibitor.	Arginine	10-18	5'-nucleotidase, cytosolic II	Homo sapiens	67-70
8978749-6	1997	It is suggested that the NO production and subsequent cyclic GMP elevation induced by arginine are responsible for the potentiation of carbachol-induced Ca2+ increase.	Arginine	86-94	5'-nucleotidase, cytosolic II	Homo sapiens	61-64
8955162-9	1996	When compared with wild type Nmt1p, Cys217 --&gt; Arg produces 3- and 6-fold increases in Ki for SC-58272 at 24 and 37 degrees C but no change in Ki for S-(2-oxo)pentadecyl-CoA, indicating that the substitution selectively affects Nmt1p"s peptide binding site.	Arginine	50-53	glycylpeptide N-tetradecanoyltransferase NMT1	Saccharomyces cerevisiae S288C	29-34
8955162-9	1996	When compared with wild type Nmt1p, Cys217 --&gt; Arg produces 3- and 6-fold increases in Ki for SC-58272 at 24 and 37 degrees C but no change in Ki for S-(2-oxo)pentadecyl-CoA, indicating that the substitution selectively affects Nmt1p"s peptide binding site.	Arginine	50-53	glycylpeptide N-tetradecanoyltransferase NMT1	Saccharomyces cerevisiae S288C	231-236
9010868-10	1996	The underlying genetic defect is a mutation in codon 172 of the RDS/peripherin gene, a gene expressed in both rods and cones, which results in the substitution of tryptophan for an arginine residue at that position.	Arginine	181-189	peripherin 2	Homo sapiens	64-78
9394497-4	1996	We found that the enzyme is dependent on the presence of calcium, calmodulin and NADPH and is inhibited by the arginine analog L-NG-nitroarginine.	Arginine	111-119	calmodulin 2	Gallus gallus	66-76
8948483-4	1996	The model predicts that substrate binding and specificity differs between AcCP-1 and cathepsin B, and demonstrates that AcCP-1 would preferentially cleave Phe-Arg over Arg-Arg.	Arginine	159-162	cathepsin B	Homo sapiens	85-96
8948483-4	1996	The model predicts that substrate binding and specificity differs between AcCP-1 and cathepsin B, and demonstrates that AcCP-1 would preferentially cleave Phe-Arg over Arg-Arg.	Arginine	168-171	cathepsin B	Homo sapiens	85-96
8910468-12	1996	Four SSeCKS domains containing Lys/Arg-rich motifs similar to the PKC phosphorylation site in MARCKS were phosphorylated in vitro by PKC.	Arginine	35-38	protein kinase C, alpha	Rattus norvegicus	66-69
8910468-12	1996	Four SSeCKS domains containing Lys/Arg-rich motifs similar to the PKC phosphorylation site in MARCKS were phosphorylated in vitro by PKC.	Arginine	35-38	protein kinase C, alpha	Rattus norvegicus	133-136
8944673-3	1996	After an arginine bolus, insulin concentration was greater in the PHG group at two of four sampling times over 30 min compared with the control group and at all times compared with the HG and LG groups.	Arginine	9-17	LOC105613195	Ovis aries	25-32
8900174-9	1996	Three photo-labeled residues, His-244 (alpha3 helix), Met-308, and Arg-310 (alpha4/beta6 interface), were specifically identified as photoinsertion sites.	Arginine	67-70	immunoglobulin binding protein 1	Homo sapiens	76-88
8895660-1	1996	Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins.	Arginine	157-165	serine and arginine rich splicing factor 1	Homo sapiens	47-54
8855938-3	1996	The three independently determined thrombin/G17 psi complexes in the crystal asymmetric unit reveal novel interactions for the P2" and P3" residues-Pro-18f and Arg-19f, respectively-on the carboxyl-terminal side of the scissile bond and confirm previously observed interactions of the P1 (Arg-16f) through P10 (Asp-7f) positions on the amino-terminal side.	Arginine	160-163	coagulation factor II, thrombin	Bos taurus	35-43
8855938-3	1996	The three independently determined thrombin/G17 psi complexes in the crystal asymmetric unit reveal novel interactions for the P2" and P3" residues-Pro-18f and Arg-19f, respectively-on the carboxyl-terminal side of the scissile bond and confirm previously observed interactions of the P1 (Arg-16f) through P10 (Asp-7f) positions on the amino-terminal side.	Arginine	289-292	coagulation factor II, thrombin	Bos taurus	35-43
8798720-5	1996	Tryptic peptide mapping of ASF/SF2 revealed that three of the phosphopeptides from full-length ASF/SF2 phosphorylated in vitro contain consecutive phosphoserine-arginine residues or phosphoserine-proline residues.	Arginine	161-169	serine and arginine rich splicing factor 1	Homo sapiens	27-34
8798720-5	1996	Tryptic peptide mapping of ASF/SF2 revealed that three of the phosphopeptides from full-length ASF/SF2 phosphorylated in vitro contain consecutive phosphoserine-arginine residues or phosphoserine-proline residues.	Arginine	161-169	serine and arginine rich splicing factor 1	Homo sapiens	95-102
8927709-3	1996	The cell line IGR39D was transfected with the MYC oncogene, the proto-oncogene NRAS, NRAS activated by a point mutation (61-arginine) or a combination of mutated NRAS and MYC.	Arginine	124-132	NRAS proto-oncogene, GTPase	Homo sapiens	85-89
8923733-6	1996	The deduced amino acid sequences of Icl1 and Icl2 differ in a conserved motif used to identify isocitrate lyases, the hexapeptide KKCGHM, where the second lysine residue of Icl1 is replaced by an arginine in Icl2.	Arginine	196-204	methylisocitrate lyase ICL2	Saccharomyces cerevisiae S288C	45-49
8798625-7	1996	Dexamethasone also prevented a cytokine-mediated increase in L-arginine uptake into CMEC by suppressing the induction of the high affinity cationic amino acid transporters CAT-1 and CAT-2B and the low affinity CAT-2A transporter.	Arginine	61-71	solute carrier family 7 member 1	Homo sapiens	172-177
8798637-0	1996	Induced nitric oxide synthesis is dependent on induced alternatively spliced CAT-2 encoding L-arginine transport in brain astrocytes.	Arginine	92-102	solute carrier family 7 member 2	Rattus norvegicus	77-82
8702602-12	1996	Arg-200, Ser-228, and Asp-549 are conserved in cPLA2 from six species and also in four nonmammalian phospholipase B enzymes.	Arginine	0-3	phospholipase A2 group IVA	Homo sapiens	47-52
8702429-2	1996	TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment.	Arginine	115-125	5'-nucleotidase, cytosolic II	Homo sapiens	77-80
8700541-1	1996	The PDGF beta-receptor in which the active-site lysine in the kinase domain has been mutated to arginine (K634R) tacks intrinsic kinase activity.	Arginine	96-104	platelet derived growth factor subunit B	Homo sapiens	4-13
8700546-8	1996	In addition, Arg, like c-Abl, is expressed as myristoylated and nonmyristoylated isoforms, suggesting that it may have dual cytoplasmic subcellular localizations, and possibly participate in diverse signaling pathways.	Arginine	13-16	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	23-28
8793795-7	1996	The neutropenia was slight and independent of membrane brand, as were the changes in C3a des arg and SC5b-9 complement components.	Arginine	93-96	complement C3	Homo sapiens	85-88
8752681-4	1996	These results disclosed a G-to-A transition within exon 73 of COL7A1, which results in a glycine-to-arginine substitution within the triple-helical domain of type VII collagen in affected individuals.	Arginine	100-108	collagen type VII alpha 1 chain	Homo sapiens	62-68
8621588-8	1996	These residues are predicted to form a contiguous binding site centered around an arginine residue in the F strand that is conserved in all members of the sialoadhesin family.	Arginine	82-90	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	155-167
8621077-1	1996	The Arg-encoding triplet (AGG) in the recognition sequence Ile-Glu-Gly-Arg for factor Xa can be used to generate a StuI restriction site (AGGCCT) which greatly facilitates the construction of DNA fragments encoding fusion proteins.	Arginine	4-7	coagulation factor X	Homo sapiens	79-88
8621077-1	1996	The Arg-encoding triplet (AGG) in the recognition sequence Ile-Glu-Gly-Arg for factor Xa can be used to generate a StuI restriction site (AGGCCT) which greatly facilitates the construction of DNA fragments encoding fusion proteins.	Arginine	71-74	coagulation factor X	Homo sapiens	79-88
8610170-3	1996	Several essential splicing factors from animals, such as SF2/ASF and SC-35, belong to a family of highly conserved proteins consisting of one or two RNA binding domain(s) (RRM) and a C-terminal Ser/Arg-rich (SR or RS) domain.	Arginine	198-201	serine and arginine rich splicing factor 1	Homo sapiens	57-60
8610170-3	1996	Several essential splicing factors from animals, such as SF2/ASF and SC-35, belong to a family of highly conserved proteins consisting of one or two RNA binding domain(s) (RRM) and a C-terminal Ser/Arg-rich (SR or RS) domain.	Arginine	198-201	serine and arginine rich splicing factor 1	Homo sapiens	61-64
8644730-5	1996	Analysis of the maternal COL7A1 allele revealed a glycine-to-arginine substitution in exon 91 (G2351R).	Arginine	61-69	collagen type VII alpha 1 chain	Homo sapiens	25-31
8733382-5	1996	This substitution converts a glycine residue (GGT) within the Gly-X-Y region of the type VII collagen triple helix into an arginine residue (CGT), and leads to the creation of a new MnlI restriction site.	Arginine	123-131	UDP glycosyltransferase 8	Homo sapiens	141-144
8639500-3	1996	Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity.	Arginine	113-116	arginyl aminopeptidase	Homo sapiens	161-164
8639500-3	1996	Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity.	Arginine	121-124	arginyl aminopeptidase	Homo sapiens	161-164
8665924-8	1996	Substitution of His382 of MAO-B with an Arg greatly reduced the enzymic activity, suggesting that this residue may represent a nucleophile relevant for the MAO-B catalytic mechanism.	Arginine	40-43	monoamine oxidase B	Homo sapiens	26-31
8665924-8	1996	Substitution of His382 of MAO-B with an Arg greatly reduced the enzymic activity, suggesting that this residue may represent a nucleophile relevant for the MAO-B catalytic mechanism.	Arginine	40-43	monoamine oxidase B	Homo sapiens	156-161
8621437-2	1996	Replacement of lysine 72 in RecA protein with arginine produces a mutant protein that binds but does not hydrolyze ATP.	Arginine	46-54	RAD51 recombinase	Homo sapiens	28-32
8577769-9	1996	An analysis of residues in the Shc PTB domain required for binding to Tyr(P) sites identified a specific and evolutionarily conserved Arg (Arg-175) that is uniquely important for ligand binding and is potentially involved in Tyr(P) recognition.	Arginine	134-137	polypyrimidine tract binding protein 1	Homo sapiens	35-38
8577769-9	1996	An analysis of residues in the Shc PTB domain required for binding to Tyr(P) sites identified a specific and evolutionarily conserved Arg (Arg-175) that is uniquely important for ligand binding and is potentially involved in Tyr(P) recognition.	Arginine	139-142	polypyrimidine tract binding protein 1	Homo sapiens	35-38
8636223-1	1996	Integrin alpha v beta 3 is distinct in its capacity to recognize the sequence Arg-Gly-Asp (RGD) in many extra-cellular matrix (ECM) components.	Arginine	78-81	integrin subunit alpha V	Homo sapiens	0-23
8567962-2	1996	Until recently, conversion of arginine to agmatine by arginine decarboxylase (ADC) was considered important only in plants and bacteria.	Arginine	30-38	antizyme inhibitor 2	Rattus norvegicus	54-76
8698744-4	1996	Sequencing of the corresponding region has confirmed preliminary data indicating that the single-base changes CGT (Arg) to TGT (Cys) or CGT to CAT (His) occurred.	Arginine	115-118	UDP glycosyltransferase 8	Homo sapiens	110-113
8836008-7	1996	In view of these findings with the alpha-hydroxyacyl-prolyl-arginals, it is very likely that the less favorable biologic properties of Boc-D-Phe-Pro-Arg-H are due to the hydrophobicity and bulkiness of the terminal Boc-NH rather than its neutrality.	Arginine	149-152	BOC cell adhesion associated, oncogene regulated	Homo sapiens	135-138
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Arginine	91-99	purinergic receptor P2Y2	Homo sapiens	34-38
8537336-5	1995	A close comparison with the human P2Y2 sequence reveals the conservation of histidine 262, arginine 265, lysine 289, and arginine 292, which were reported to be involved in nucleotide binding (Erb, L., Garrad, R., Wang, Y., Quinn, T., Turner, J. T., and Weisman, G. A.	Arginine	121-129	purinergic receptor P2Y2	Homo sapiens	34-38
8532535-2	1995	Sequence-specific recognition requires arginine residues found within three perfectly repeated pentads (G-R-K-P-G) of the Dat1p DNA binding domain [Reardon, B. J., Winters, R. S., Gordon, D., and Winter, E. (1993) Proc.	Arginine	39-47	Dat1p	Saccharomyces cerevisiae S288C	122-127
8787788-1	1995	We have investigated the inhibitory effect of the N-terminal modified Arg-Gly-Asp-Ser (RGDS) analogues, AcDRGDS and AcDRLDS, on tumor cell adhesion to the components of extracellular matrix and basement membrane, and also tested the antimetastatic effect of their conjugates with trimesic acid, Ar(DRGDS)3 and Ar(DRLDS)3.	Arginine	70-73	ral guanine nucleotide dissociation stimulator	Mus musculus	87-91
7565304-7	1995	In addition, one of 15 PNETs retained heterozygosity but demonstrated a somatic CGT to TGT transition (arg to cys) at codon 273.	Arginine	103-106	UDP glycosyltransferase 8	Homo sapiens	80-83
7488288-8	1995	Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar Arg/Lys residues, represent cross-reactive epitopes between the two proteins.	Arginine	177-180	HTLV-1 related endogenous sequence	Homo sapiens	22-28
7488288-8	1995	Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar Arg/Lys residues, represent cross-reactive epitopes between the two proteins.	Arginine	181-184	HTLV-1 related endogenous sequence	Homo sapiens	22-28
7488288-8	1995	Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar Arg/Lys residues, represent cross-reactive epitopes between the two proteins.	Arginine	181-184	HTLV-1 related endogenous sequence	Homo sapiens	22-28
7488288-8	1995	Antigenic epitopes of HRES-1 and the retroviral gag-related region of the 70-kd protein component of U1 small nuclear RNP, which share 3 consecutive highly charged amino acids (Arg-Arg-Glu), an additional Arg, and functionally similar Arg/Lys residues, represent cross-reactive epitopes between the two proteins.	Arginine	181-184	HTLV-1 related endogenous sequence	Homo sapiens	22-28
7559478-19	1995	Conversely, substitution of Leu-961 (+1) with either Ala or Arg reduced SHC interaction by 70 and 90%, respectively, yet had no effect upon interaction with IRS-1.	Arginine	60-63	SHC adaptor protein 1	Homo sapiens	72-75
7665587-5	1995	Thus, endopeptidase 24-15 exhibits a marked preference for inhibitors containing a basic residue (Arg or Lys) in the P2" position, while 24-16 prefers a proline in this position.	Arginine	98-101	thimet oligopeptidase 1	Rattus norvegicus	6-25
7594769-1	1995	Previous studies showed that nitric oxide (NO), synthesized from L-arginine (L-arg) by NO synthase (NOS) in vascular epithelium and nerve terminals, affects exocrine pancreatic secretion, but its role in control of endocrine pancreas has not been studied.	Arginine	65-75	nitric oxide synthase 3	Canis lupus familiaris	87-98
7594769-1	1995	Previous studies showed that nitric oxide (NO), synthesized from L-arginine (L-arg) by NO synthase (NOS) in vascular epithelium and nerve terminals, affects exocrine pancreatic secretion, but its role in control of endocrine pancreas has not been studied.	Arginine	65-70	nitric oxide synthase 3	Canis lupus familiaris	87-98
7619799-5	1995	Kinetic analysis of the wild-type and mutant enzymes revealed that the amino acid differences occurring at positions 10 (Val/Ser), 11 (Arg/Pro), and 104 (Val/Gly) are responsible for the reduced enzymatic activity of Gst p-2.	Arginine	135-138	glutathione S-transferase, pi 2	Mus musculus	217-224
7624374-1	1995	PR-39 is a porcine 39-aa peptide antibiotic composed of 49% proline and 24% arginine, with an activity against Gram-negative bacteria comparable to that of tetracycline.	Arginine	76-84	antibacterial protein PR-39	Sus scrofa	0-5
7607641-4	1995	DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His.	Arginine	204-207	lecithin-cholesterol acyltransferase	Homo sapiens	82-86
7607641-4	1995	DNA sequence analysis of polymerase chain reaction (PCR)-amplified DNA of all six LCAT exons revealed a new point mutation in exon IV of the LCAT gene, i.e., a G to A substitution in codon 140 converting Arg to His.	Arginine	204-207	lecithin-cholesterol acyltransferase	Homo sapiens	141-145
7592091-10	1995	Plasma glucagon responses to feeding (P &lt; .05) and plasma insulin responses to arginine injection (P &lt; .01) were reduced by cold exposure.	Arginine	82-90	LOC105613195	Ovis aries	61-68
8537247-3	1995	Competition experiments showed that the androgen receptor had an approximately 100-fold more affinity for the PSA ARE than for the arginine sequence at -172 to -148.	Arginine	131-139	androgen receptor	Canis lupus familiaris	40-57
7616106-0	1995	Binding of Gc globulin (vitamin D binding protein) to C5a or C5a des Arg is not necessary for co-chemotactic activity.	Arginine	69-72	GC vitamin D binding protein	Homo sapiens	11-22
7616106-0	1995	Binding of Gc globulin (vitamin D binding protein) to C5a or C5a des Arg is not necessary for co-chemotactic activity.	Arginine	69-72	GC vitamin D binding protein	Homo sapiens	24-49
7616106-1	1995	Gc globulin (vitamin D binding protein) has been shown to augment significantly the leukocyte chemotactic activity of the activated complement peptides C5a and C5a des Arg.	Arginine	168-171	GC vitamin D binding protein	Homo sapiens	0-11
7616106-1	1995	Gc globulin (vitamin D binding protein) has been shown to augment significantly the leukocyte chemotactic activity of the activated complement peptides C5a and C5a des Arg.	Arginine	168-171	GC vitamin D binding protein	Homo sapiens	13-38
7616106-8	1995	These results indicate that the binding of C5a/C5a des Arg to Gc globulin is not necessary for their chemotactic activity to be augmented.	Arginine	55-58	GC vitamin D binding protein	Homo sapiens	62-73
7797592-3	1995	Both were highly homologous to human ICE (52% identical) and CED-3 (25% identical) and both contained the absolutely conserved pentapeptide sequence Gln-Ala-Cys-Arg-Asp containing the catalytic cysteine residue.	Arginine	161-164	intraflagellar transport 43	Homo sapiens	61-66
7596817-1	1995	Several nucleolar proteins, such as nucleolin, NOP1/fibrillarin, SSB1, NSR1 and GAR1 share a common glycine and arginine rich structural motif called the GAR domain.	Arginine	112-120	Nsr1p	Saccharomyces cerevisiae S288C	71-75
7758132-13	1995	Thus, AP and MLR were preserved in LPD groups which may be related to a loss of prostaglandin- and L-arginine-mediated suppressor mechanisms.	Arginine	99-109	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Mus musculus	35-38
7788012-5	1995	In conclusion, the neuroregulation of GH release seems to be similar qualitatively in normal-weight and obese youngsters; the different behavior observed after arginine, which is supposed to act through somatostatin inhibition, might be due to a chronic increase in somatostatinergic tone responsible for the lower stimulated GH levels in obesity.	Arginine	160-168	somatostatin	Homo sapiens	203-215
7673361-3	1995	The p62 is endoproteolytically cleaved at a tetrabasic Arg-His-Arg-Arg recognition sequence.	Arginine	55-58	nucleoporin 62	Homo sapiens	4-7
7673361-3	1995	The p62 is endoproteolytically cleaved at a tetrabasic Arg-His-Arg-Arg recognition sequence.	Arginine	63-66	nucleoporin 62	Homo sapiens	4-7
7791347-1	1995	BACKGROUND/AIMS: Nitric oxide (NO) is generated in vascular endothelium and enteric neural plexuses from L-arginine by the action of nitric oxide synthase (NOS).	Arginine	105-115	nitric oxide synthase 3	Canis lupus familiaris	133-154
7589156-7	1995	The inhibition of nitric oxide (NO) synthase, by NG-nitro-L-arginine methyl ester almost completely eliminated both the protective and hyperemic effects of gastrin-17 and the addition of L-arginine (but not D-arginine) to NG-nitro-L-arginine-methyl ester restored, in part, these effects of gastrin-17.	Arginine	58-68	gastrin	Rattus norvegicus	156-163
7589156-9	1995	We conclude that both exogenous and endogenous gastrin exert its protective activity against ethanol damage of gastric mucosa and this effect is mediated through the interaction with specific CCKB receptors and arginine-NO pathway, but does not involve sensory nerves.	Arginine	211-219	gastrin	Rattus norvegicus	47-54
7538661-8	1995	This region includes the arginine-rich motif VI, the most carboxy terminal conserved domain of RNA helicases of the superfamily SF2.	Arginine	25-33	serine and arginine rich splicing factor 1	Homo sapiens	128-131
7733664-1	1995	The functional role of arginine residues in glycogen phosphorylase b was probed by enzymatic modification by using peptidylarginine deiminase, which converts arginine residues to citrulline.	Arginine	23-31	glycogen phosphorylase B	Homo sapiens	44-68
7733664-1	1995	The functional role of arginine residues in glycogen phosphorylase b was probed by enzymatic modification by using peptidylarginine deiminase, which converts arginine residues to citrulline.	Arginine	123-131	glycogen phosphorylase B	Homo sapiens	44-68
7890750-7	1995	The single basic amino acid close to Thr-431 (Arg-429) is essential for recognition of the peptide as a substrate by PKC delta and for the selectivity of this recognition.	Arginine	46-49	protein kinase C, delta	Mus musculus	117-126
7758256-1	1995	The clinical characteristics of subjects with a missense glucokinase mutation, gly299--&gt;arg, were studied in a large pedigree, BX, initially characterized by some members having Maturity Onset Diabetes of the Young (MODY).	Arginine	91-94	glucokinase	Homo sapiens	57-68
7758256-4	1995	Subjects with glucokinase gly299--&gt;arg were the same age, height, and obesity as the subjects without the mutation.	Arginine	38-41	glucokinase	Homo sapiens	14-25
7861014-3	1995	Examination of the polymerase chain reaction corresponding to exon 73 revealed a heteroduplex resulting from a G-to-A transition at nucleotide 6127 in the triple-helical domain of COL7A1, which converted a glycine residue to an arginine (G2043R).	Arginine	228-236	collagen type VII alpha 1 chain	Homo sapiens	180-186
7847389-4	1995	A genomic polymorphism of LMP7 was found strongly associated with IDDM, and the Arg/His-60 polymorphism in LMP2 was found associated with IDDM only in subjects containing an HLA DR4-DQB1*0302 haplotype.	Arginine	80-83	major histocompatibility complex, class II, DR beta 4	Homo sapiens	178-181
7795148-0	1995	Hybrid peptide containing RGDF (Arg-Gly-Asp-Phe) coupled with the carboxy terminal part of alpha 2-antiplasmin capable of inhibiting platelet aggregation and promoting fibrinolysis.	Arginine	32-35	serpin family F member 2	Homo sapiens	91-110
7542422-5	1995	Double immunohistochemical staining using anti-tau with either anti-microtubule-associated protein 2 or anti-neurofilament 200K revealed that ArG were intimately associated with dendrites rather than with axons.	Arginine	142-145	microtubule associated protein 2	Homo sapiens	68-100
7762978-9	1995	A comparison of the entire translated sequences of the DNase I gene from two pairs of individuals with common DNase I phenotypes 1 and 2 revealed only one nucleotide residue difference in exon VIII, A for phenotype 1 and G for phenotype 2, thus producing Gln and Arg amino acid substitutions respectively at position 222 from the NH2-terminus of the mature enzyme.	Arginine	263-266	deoxyribonuclease 1	Homo sapiens	55-62
8821790-11	1995	Since Tyr401 is known to be in the channel pore, these results suggest that either or both of the Arg residues at positions 13 and 19 of mu-CTX interact(s) with residue Tyr401 of rSkM1 and, therefore, indicate that mu-CTX extends into the pore region of the channel.	Arginine	98-101	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	179-184
7830718-7	1994	Having shown a role for the VirB4 protein in DNA transfer, lysine-439, found within the conserved mononucleotide binding domain of VirB4, was changed to a glutamic acid, methionine, or arginine by oligonucleotide-directed mutagenesis.	Arginine	185-193	type IV secretion system protein VirB4	Agrobacterium tumefaciens	28-33
7529002-5	1994	Infusion of 1 microgram.kg-1.min-1 in ASC (n = 6) did not change BP or GFR but significantly enhanced UV and UNaV after the 1st h. These effects were prevented by pretreatment with L-arginine (0.1 mg.kg-1.min-1) in another group of ASC infused with 1 microgram.kg-1.min-1 of L-NAME.	Arginine	181-191	PYD and CARD domain containing	Rattus norvegicus	38-41
7529002-5	1994	Infusion of 1 microgram.kg-1.min-1 in ASC (n = 6) did not change BP or GFR but significantly enhanced UV and UNaV after the 1st h. These effects were prevented by pretreatment with L-arginine (0.1 mg.kg-1.min-1) in another group of ASC infused with 1 microgram.kg-1.min-1 of L-NAME.	Arginine	181-191	PYD and CARD domain containing	Rattus norvegicus	232-235
7949143-5	1994	Molecular analysis of the genes encoding cytochrome b558 subunits shows, in case 1, a C-->T substitution at nucleotide 688 of the gene encoding the gp91-phox subunit of cytochrome b558, resulting in a termination signal in place of Arginine-226.	Arginine	232-240	cytochrome b-245 beta chain	Homo sapiens	148-157
7958490-0	1994	Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.	Arginine	24-32	glucokinase	Homo sapiens	90-101
8556514-2	1994	We investigated the His-Arg (CAT/CGT) polymorphism at codon 131 of the Fc gamma receptor IIA gene, which influences ligand binding by the receptor.	Arginine	24-27	UDP glycosyltransferase 8	Homo sapiens	33-36
7929459-2	1994	AR contains an EGF-like domain (residues 44-84) and a Lys/Arg-rich NH2-terminal extension (residues 1-43).	Arginine	58-61	amphiregulin	Homo sapiens	0-2
7926838-4	1994	When the N-terminal, lysine- and arginine-rich domain of Nsr1 was removed, the truncated protein behaved similarly to hnRNP A1; furthermore, the two RRM (RNA recognition motif) domains of Nsr1 behaved in the same manner as the two RRM domains of hnRNP A1.	Arginine	33-41	Nsr1p	Saccharomyces cerevisiae S288C	57-61
7926458-11	1994	CONCLUSIONS: CCK is involved in the occurrence of transient lower esophageal sphincter relaxations through peripheral CCK-A receptors and an L-arginine nitric oxide pathway.	Arginine	141-151	cholecystokinin	Canis lupus familiaris	13-16
7875931-1	1994	The Ser(P)-containing peptide corresponding to phospholamban 11-19, Ac-Ala-Ile-Arg-Arg-Ala-Ser(P)-Thr-Ile-Glu-NH2, was prepared by the use of Boc-Ser(PO3Ph2)-OH in Boc/solid-phase peptide synthesis followed by HF cleavage of the peptide from the polystyrene resin and subsequent platinum-mediated hydrogenolytic cleavage of the phenyl phosphate groups.	Arginine	79-82	BOC cell adhesion associated, oncogene regulated	Homo sapiens	142-145
7875931-1	1994	The Ser(P)-containing peptide corresponding to phospholamban 11-19, Ac-Ala-Ile-Arg-Arg-Ala-Ser(P)-Thr-Ile-Glu-NH2, was prepared by the use of Boc-Ser(PO3Ph2)-OH in Boc/solid-phase peptide synthesis followed by HF cleavage of the peptide from the polystyrene resin and subsequent platinum-mediated hydrogenolytic cleavage of the phenyl phosphate groups.	Arginine	79-82	BOC cell adhesion associated, oncogene regulated	Homo sapiens	164-167
8091650-9	1994	Replacement of serine in the P1" position with other polar amino acids, with amino acids having aliphatic side chains, or with arginine resulted in NS3-mediated cleavage.	Arginine	127-135	KRAS proto-oncogene, GTPase	Homo sapiens	148-151
8062279-2	1994	Five of these clones and the parental cell line showed a mutation at codon 61 of N-RAS that resulted in Gln--&gt;Arg substitution (N-RAS/61+), while in the remaining 14, only the wild-type allele for N-RAS was present (N-RAS/61-).	Arginine	113-116	NRAS proto-oncogene, GTPase	Homo sapiens	81-86
7988304-4	1994	RESULTS: IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQ beta-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQ alpha-chain.	Arginine	173-176	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	46-50
8060313-0	1994	A cell-binding Arg-Gly-Asp sequence is present in close proximity to the major linear antigenic region of HCV NS3.	Arginine	15-18	KRAS proto-oncogene, GTPase	Homo sapiens	110-113
8060313-1	1994	By sequence analysis of the HCV NS3 protein we identified an Arg-Gly-Asp (RGD) motif, which is a known sequence for integrin-mediated cell adhesion, within a region of high hydrophilicity and surface probability.	Arginine	61-65	KRAS proto-oncogene, GTPase	Homo sapiens	32-35
8049275-3	1994	Mosquito rpL31 had a mass of 15,137 Da, a pI of 12.39 and contained 14.5% Arg and 14.5% Lys.	Arginine	74-77	ribosomal protein L31	Rattus norvegicus	9-14
8036014-2	1994	It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991).	Arginine	29-32	vitronectin	Homo sapiens	218-229
8036014-2	1994	It contains a functional gly-arg-gly-asp-ser (GRGDS) integrin binding domain (Oldberg et al., 1986), promotes the adhesion of a variety of cell types (Somerman et al., 1989; Brown et al., 1992) and is a ligand for the vitronectin binding integrin alpha v beta 3 (Miyauchi et al., 1991).	Arginine	29-32	integrin subunit alpha V	Homo sapiens	238-261
7522930-1	1994	Available studies indicate that the adrenergic stimulation of pineal cyclic GMP production involves stimulation of guanylyl cyclase activity by nitric oxide (NO) derived from arginine.	Arginine	175-183	5'-nucleotidase, cytosolic II	Homo sapiens	76-79
7517876-2	1994	C5a is very rapidly degraded by serum carboxypeptidase N which cleaves the functionally important carboxy-terminal arginine, generating C5desarg, a chemotactic agonist with little mast cell-activating ability.	Arginine	115-123	carboxypeptidase N subunit 1	Homo sapiens	32-56
7524891-0	1994	Bioactive Arg-Gly-Asp conformations in anti-integrin GPIIb-IIIa antibodies.	Arginine	10-13	integrin subunit alpha 2b	Homo sapiens	53-58
8024578-1	1994	An amino acid sequence (Arg-Gly-Asp-Val) specifically associating with cell adhesion between cells and extracellular matrices was found on the human Zn-alpha 2-glycoprotein (Zn alpha 2gp) molecule.	Arginine	24-27	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	149-172
8024578-1	1994	An amino acid sequence (Arg-Gly-Asp-Val) specifically associating with cell adhesion between cells and extracellular matrices was found on the human Zn-alpha 2-glycoprotein (Zn alpha 2gp) molecule.	Arginine	24-27	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	174-186
8016118-1	1994	N-Arg dibasic convertase is a metalloendopeptidase from rat brain cortex and testis that cleaves peptide substrates on the N terminus of Arg residues in dibasic stretches.	Arginine	2-5	thimet oligopeptidase 1	Rattus norvegicus	30-50
8002978-5	1994	The murine Fic cDNA, which encodes a Marc-mutant protein with an arginine substitution for alanine, was not identified in the other sequenced homologous isolates.	Arginine	65-73	chemokine (C-C motif) ligand 7	Mus musculus	11-14
8002978-5	1994	The murine Fic cDNA, which encodes a Marc-mutant protein with an arginine substitution for alanine, was not identified in the other sequenced homologous isolates.	Arginine	65-73	chemokine (C-C motif) ligand 7	Mus musculus	37-41
8010958-0	1994	The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.	Arginine	80-83	citrate synthase	Sus scrofa	148-164
8010958-2	1994	Active-site residues Arg-314, Asp-312 and His-264 in Escherichia coli citrate synthase, which are involved in oxaloacetate binding, were converted by site-directed mutagenesis to Gln-314, Asn-312 and Asn-264 respectively.	Arginine	21-24	citrate synthase	Sus scrofa	70-86
8195186-10	1994	Although the amino acid sequences of the isoforms differ in only 21 of 43 residues with the majority of substitutions being conservative, the apparent affinity of CAT2 beta for arginine uptake was 70-fold higher than the CAT2 alpha isoform (Km 38 microM versus 2.7 mM).	Arginine	177-185	dominant cataract 2	Mus musculus	163-167
8023953-0	1994	Inhibition of C5a des Arg-induced neutrophil alveolitis in transgenic mice expressing C-reactive protein.	Arginine	22-25	C-reactive protein, pentraxin-related	Mus musculus	86-104
8023953-4	1994	After direct instillation of a known inflammatory agent (C5a des Arg) into the airways, transgenic mice with high plasma levels of CRP showed significantly diminished infiltration of neutrophils into bronchoalveolar lavage fluid (BALF) and a significant reduction of BALF total protein levels compared with normal mice.	Arginine	65-68	C-reactive protein, pentraxin-related	Mus musculus	131-134
7525451-3	1994	Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469.	Arginine	64-67	intercellular adhesion molecule 1	Homo sapiens	49-55
7834769-5	1994	L-arginine (0.5 g/kg) reversed the effect of L-NAME (5 mg/kg) on mPAP and PVR at hypoxic ventilation within one hour.	Arginine	0-10	PVR cell adhesion molecule	Canis lupus familiaris	74-77
8070905-0	1994	Gc globulin (vitamin D-binding protein) increases binding of low concentrations of C5a des Arg to human polymorphonuclear leukocytes: an explanation for its cochemotaxin activity.	Arginine	91-94	GC vitamin D binding protein	Homo sapiens	0-11
8070905-1	1994	The chemotactic activity of native human C5a des Arg is enhanced significantly by the normal serum and plasma protein Gc globulin (vitamin D-binding protein).	Arginine	49-52	GC vitamin D binding protein	Homo sapiens	118-129
8070905-2	1994	Gc globulin attaches to sialic acid residues within the oligosaccharide chain of C5a des Arg to form a complex with potent chemotactic activity for human PMN.	Arginine	89-92	GC vitamin D binding protein	Homo sapiens	0-11
8070905-3	1994	We investigated the mechanism whereby this phenomenon may occur and found that Gc globulin enhanced the binding of low concentrations of [125I]C5a des Arg to PMN, but had no effect on C5a-induced displacement of bound [125]C5a des Arg.	Arginine	151-154	GC vitamin D binding protein	Homo sapiens	79-90
8070905-4	1994	Gc globulin bound to PMN, and probably acted as a C5a des Arg chaperon.	Arginine	58-61	GC vitamin D binding protein	Homo sapiens	0-11
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	60-63	GC vitamin D binding protein	Homo sapiens	22-33
8070905-5	1994	Thus, it appears that Gc globulin, by complexing to C5a des Arg, increases the number of C5a des Arg molecules per unit of PMN membrane without affecting its affinity of binding.	Arginine	97-100	GC vitamin D binding protein	Homo sapiens	22-33
8070905-6	1994	This phenomenon provides a plausible explanation for the enhancing effect of Gc globulin on the chemotactic activity of low concentrations of native human C5a des Arg.	Arginine	163-166	GC vitamin D binding protein	Homo sapiens	77-88
8125961-6	1994	Additional experiments have been carried out on the nonreceptor tyrosine kinase v-Abl using a peptide library based on the v-Src autophosphorylation site (Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly).	Arginine	155-158	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	80-85
8120452-5	1994	However, Gc-globulin, at concentrations as low as 10 pM, increased monocyte chemotaxis over 10-fold in a concentration-dependent fashion when added to non-chemotactic doses of C5a (0.1 nM) and C5a des Arg (0.5 nM).	Arginine	201-204	GC vitamin D binding protein	Homo sapiens	9-20
8290568-8	1994	Biochemical analysis of one FHC mutant (Arg-249--&gt;Gln) demonstrates that the structures formed by the mutant are solubilized at a lower ionic strength than those formed by wild-type MHC.	Arginine	40-43	major histocompatibility complex, class I, C	Homo sapiens	185-188
8276829-2	1994	We report properties of five active site mutants of Escherichia coli citrate synthase, in which histidine 264, aspartate 362, and phenylalanine 383 were replaced by alanines, and arginines 387 and 407 by leucines.	Arginine	179-188	citrate synthase	Sus scrofa	69-85
8280781-0	1994	Arg-129 plays a specific role in the conformation of antithrombin and in the enhancement of factor Xa inhibition by the pentasaccharide sequence of heparin.	Arginine	0-3	coagulation factor X	Homo sapiens	92-101
8290340-3	1993	Here, we examined the potential dual roles of the flanking lysine and arginine residues in influencing the redox reactivity of the cysteine and the DNA-binding activity of Fos and Jun.	Arginine	70-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-175
8290340-11	1993	This suggests that the lysine and arginine residues in the KCR region of Fos are not equivalent to those in Jun and that they interact with DNA differently.	Arginine	34-42	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-76
8267567-6	1993	In the affected males of kindred B, a G to C substitution was found at nucleotide 428, altering codon 143 from arginine (CGT) to proline (CCT) in the second cytoplasmic domain.	Arginine	111-119	UDP glycosyltransferase 8	Homo sapiens	121-124
8267567-6	1993	In the affected males of kindred B, a G to C substitution was found at nucleotide 428, altering codon 143 from arginine (CGT) to proline (CCT) in the second cytoplasmic domain.	Arginine	111-119	CCT	Homo sapiens	138-141
8280084-5	1993	The specificity of calmodulin-dependent protein kinase-II resembled that of MAPKAP kinase-2, except that it could tolerate replacement of the arginine by a lysine and the phosphorylation-site serine by a threonine residue.	Arginine	142-150	MAPK activated protein kinase 2	Homo sapiens	76-91
8223480-2	1993	We introduced selected mutations in the N-terminal RNA recognition motif (RRM) and the C-terminal Arg/Ser (RS) domain of SF2/ASF, and assayed the resulting recombinant proteins for constitutive and alternative splicing in vitro and for binding to pre-mRNA and mRNA.	Arginine	98-101	serine and arginine rich splicing factor 1	Homo sapiens	121-124
8223480-2	1993	We introduced selected mutations in the N-terminal RNA recognition motif (RRM) and the C-terminal Arg/Ser (RS) domain of SF2/ASF, and assayed the resulting recombinant proteins for constitutive and alternative splicing in vitro and for binding to pre-mRNA and mRNA.	Arginine	98-101	serine and arginine rich splicing factor 1	Homo sapiens	125-128
7504478-5	1993	This enzyme was recognised by antibodies to the native nNOS and showed a similar degree of inhibition by arginine analogs as the native nNOS.	Arginine	105-113	nitric oxide synthase 1	Rattus norvegicus	55-59
7504478-5	1993	This enzyme was recognised by antibodies to the native nNOS and showed a similar degree of inhibition by arginine analogs as the native nNOS.	Arginine	105-113	nitric oxide synthase 1	Rattus norvegicus	136-140
8136274-6	1993	The lesion responsible was determined by PCR/direct sequencing to be a heterozygous CGT/TGT transition in exon 3 of the protein C gene resulting in the substitution of Arg by Cys at residue--1 in the pro-peptide leader sequence.	Arginine	168-171	UDP glycosyltransferase 8	Homo sapiens	84-87
8136274-6	1993	The lesion responsible was determined by PCR/direct sequencing to be a heterozygous CGT/TGT transition in exon 3 of the protein C gene resulting in the substitution of Arg by Cys at residue--1 in the pro-peptide leader sequence.	Arginine	168-171	proline rich protein HaeIII subfamily 1	Homo sapiens	120-129
8221663-2	1993	Mutations of the p53 gene were found in six of seven ES cell lines: a missense mutation of TGC (Cys)--&gt;TAC (Try) at codon 141 in one, a missense mutation of CGT (Arg)--&gt;TGT (Cys) at codon 273 in one, a missense mutation of TGC (Cys)--&gt;TTC (Phe) at codon 176 in three, and one base deletion of CGC--&gt;CG at codon 283 in one.	Arginine	165-168	UDP glycosyltransferase 8	Homo sapiens	160-163
8143901-8	1993	Five residues (Leu-86, Cys-88, Cys-90, Arg-94, and Arg-95) were critical for maximal inhibition of hCG binding by CG beta 81-95.	Arginine	39-42	chorionic gonadotropin subunit beta 3	Homo sapiens	114-121
8143901-8	1993	Five residues (Leu-86, Cys-88, Cys-90, Arg-94, and Arg-95) were critical for maximal inhibition of hCG binding by CG beta 81-95.	Arginine	51-54	chorionic gonadotropin subunit beta 3	Homo sapiens	114-121
8344203-2	1993	Furin cleaves the concensus processing site -Arg-4-X-3-Lys/Arg-2-Arg-1 decreases X+1-.	Arginine	45-48	arginase 2	Homo sapiens	59-70
7903430-3	1993	These cells lines are known to process POMC differently at Lys-Arg residues, though less is known about their Lys-Lys cleavage.	Arginine	63-66	proopiomelanocortin	Rattus norvegicus	39-43
8388499-8	1993	The N termini are Glu-268 for E0 (gp44/48), Leu-495 for E1 (gp33) and Arg-690 for E2 (gp55).	Arginine	70-73	neuroplastin	Homo sapiens	86-90
7683657-0	1993	Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion.	Arginine	33-41	vitronectin	Homo sapiens	67-78
7683657-3	1993	Many cell adhesion ligands, including vitronectin, contain an Arg-Gly-Asp (RGD) sequence mediating, in part, the ligand-receptor interaction.	Arginine	62-65	vitronectin	Homo sapiens	38-49
8320368-7	1993	The 60 kDa protein was found to be bovine osteopontin, a very highly phosphorylated protein with an Arg-Gly-Asp sequence which mediates cell attachment.	Arginine	100-103	secreted phosphoprotein 1	Bos taurus	42-53
8388097-4	1993	This study confirms a role for both glutamate 72 and arginine 82 in cAMP binding and activation of CRP.	Arginine	53-61	catabolite gene activator protein	Escherichia coli	99-102
8098260-3	1993	The major endothelium-derived relaxing factor is nitric oxide formed from L-arginine, which activates guanylate cyclase in the smooth muscle, leading to accumulation of cyclic-GMP.	Arginine	74-84	5'-nucleotidase, cytosolic II	Homo sapiens	176-179
8486232-7	1993	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese.	Arginine	120-123	major histocompatibility complex, class II, DR beta 4	Homo sapiens	102-105
8486232-7	1993	These findings suggest that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), may contribute to the susceptibility to autoimmune hepatitis of Japanese.	Arginine	120-123	major histocompatibility complex, class II, DR beta 4	Homo sapiens	142-145
8445019-4	1993	A point mutation was discovered that changed codon 65 from arginine (CGT) to histidine (CAT) in one allele.	Arginine	59-67	UDP glycosyltransferase 8	Homo sapiens	69-72
8095045-0	1993	Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase.	Arginine	16-19	inactive glutathione hydrolase 2	Homo sapiens	72-101
8428004-4	1993	However, this difference with pro-UK was nullified by carboxypeptidase B (CpB) treatment of thromb-UK to remove the C-terminal arginine on the A-chain.	Arginine	127-135	carboxypeptidase B1	Homo sapiens	54-72
8428004-4	1993	However, this difference with pro-UK was nullified by carboxypeptidase B (CpB) treatment of thromb-UK to remove the C-terminal arginine on the A-chain.	Arginine	127-135	carboxypeptidase B1	Homo sapiens	74-77
8428004-10	1993	The effect of CpB indicates that the C-terminal Arg of thromb-UK slightly enhances its affinity for plasminogen.	Arginine	48-51	carboxypeptidase B1	Homo sapiens	14-17
8428938-12	1993	Incubation of mouse peritoneal macrophages with apoA-I(Pro165--&gt;Arg).DMPC complexes did also result in a 30% decreased efflux of radiolabeled cholesterol if compared to rHDL with the normal allele product from the same donor.	Arginine	67-70	apolipoprotein A-I	Mus musculus	48-54
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Arginine	159-162	major histocompatibility complex, class II, DR beta 4	Homo sapiens	141-144
8096552-7	1993	Comparison of the amino acid residues of DRB1 chain suggested that the basic amino acid at position 13, which is present only on the DR2 and DR4 B1 molecules (Arg on DR2 and His on DR4), contributes to the susceptibility to autoimmune hepatitis among Japanese.	Arginine	159-162	major histocompatibility complex, class II, DR beta 4	Homo sapiens	181-184
8434604-3	1993	Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position alpha 1-9 in exon 7 to a premature termination signal for translation.	Arginine	156-164	immunoglobulin kappa variable 2-28	Homo sapiens	188-197
21043846-5	1993	Like some other adhesive proteins such as fibrinogen, fibronectin, and von Willebrand factor, vitronectin contains the amino-acid sequence Arg-Gly-Asp (RGD) which enables binding to the platelet membrane glycoprotein complex IIb/IIIa (GPIIb/IIIa).	Arginine	139-142	vitronectin	Homo sapiens	94-105
21043846-5	1993	Like some other adhesive proteins such as fibrinogen, fibronectin, and von Willebrand factor, vitronectin contains the amino-acid sequence Arg-Gly-Asp (RGD) which enables binding to the platelet membrane glycoprotein complex IIb/IIIa (GPIIb/IIIa).	Arginine	139-142	integrin subunit alpha 2b	Homo sapiens	235-240
1493919-7	1992	IL-1Ra was selective for IL-1 in rabbit skin, as responses induced by C5ades Arg and formyl-methionyl-leucyl-phenylalanine (FMLP) were not inhibited.	Arginine	77-80	interleukin-1 receptor antagonist protein	Oryctolagus cuniculus	0-6
1487709-8	1992	Endo-oligopeptidase A cleaved the bonds Phe-Ser of bradykinin, Met-Arg of BAM-12P and Arg-Arg of neurotensin as described for rabbit brain and heart and bovine brain enzymes.	Arginine	67-70	nudE neurodevelopment protein 1 like 1	Homo sapiens	0-21
1487709-8	1992	Endo-oligopeptidase A cleaved the bonds Phe-Ser of bradykinin, Met-Arg of BAM-12P and Arg-Arg of neurotensin as described for rabbit brain and heart and bovine brain enzymes.	Arginine	86-89	nudE neurodevelopment protein 1 like 1	Homo sapiens	0-21
1331071-6	1992	The inactivation is strictly due to side chain functions, in particular the replacement of either or both arginines in the positions B13 or B17.	Arginine	106-115	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	140-143
1331071-7	1992	Binding is mediated by a two-prong electrostatic and hydrogen-binding interaction via arginines B13 and B17.	Arginine	86-95	NADH:ubiquinone oxidoreductase subunit B6	Homo sapiens	104-107
1447740-2	1992	Replacement of the N-terminal arginine by p-amidinophenylalanine or the Gly moiety by m-aminobenzoic acid led to compounds which are superior to the lead peptide with regard to activity and selectivity for GP IIb-IIIa vs the closely related vitronectin receptor alpha v beta 3.	Arginine	30-38	integrin subunit alpha 2b	Homo sapiens	206-212
1334529-2	1992	IS 1 mutants with a 1 bp insertion, which encode mutant transposases with an amino acid substitution within the polypeptide segment at residues 84-87, did not efficiently mediate cointegration, except for an IS 1 mutant which encodes a mutant transposase with a Leu-Arg-Lys-Leu segment instead of Leu-Lys-Lys-Leu.	Arginine	266-269	IS1	Homo sapiens	0-4
1383690-6	1992	Binding of tyrosine-phosphorylated c-ABL 1b by the relatively high-affinity ABL and ARG SH2 domains was quantitatively analyzed, and equilibrium dissociation constants for both interactions were estimated to be in the range of 5 x 10(-7) M. The ABL SH2 domain exhibited relatively high affinity for phosphotyrosine-free BCR as well; however, this interaction appears to be about two orders of magnitude weaker than binding of tyrosine-phosphorylated c-ABL 1b.	Arginine	84-87	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	35-40
1383690-6	1992	Binding of tyrosine-phosphorylated c-ABL 1b by the relatively high-affinity ABL and ARG SH2 domains was quantitatively analyzed, and equilibrium dissociation constants for both interactions were estimated to be in the range of 5 x 10(-7) M. The ABL SH2 domain exhibited relatively high affinity for phosphotyrosine-free BCR as well; however, this interaction appears to be about two orders of magnitude weaker than binding of tyrosine-phosphorylated c-ABL 1b.	Arginine	84-87	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-40
1401911-1	1992	Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands.	Arginine	158-161	CD47 molecule	Homo sapiens	0-27
1401911-1	1992	Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands.	Arginine	158-161	CD47 molecule	Homo sapiens	29-32
1335038-6	1992	A genetic mutation, causing a Ser50--&gt;Arg substitution of the TTR molecule, was identified in another family member.	Arginine	41-44	transthyretin	Homo sapiens	65-68
1303265-1	1992	We describe a codon 299 mutation in the glucokinase gene in a British pedigree with maturity-onset diabetes of the young (MODY) resulting in a substitution of glycine to arginine.	Arginine	170-178	glucokinase	Homo sapiens	40-51
1358382-13	1992	These results suggest that PAF stimulates production of nitric oxide from L-arginine by acting on the PAF receptors in the endothelium, which in turn stimulates soluble guanylate cyclase in the smooth muscle cells, and so increases production of cyclic GMP, thus relaxing the arteries.	Arginine	74-84	PCNA clamp associated factor	Rattus norvegicus	27-30
1358382-13	1992	These results suggest that PAF stimulates production of nitric oxide from L-arginine by acting on the PAF receptors in the endothelium, which in turn stimulates soluble guanylate cyclase in the smooth muscle cells, and so increases production of cyclic GMP, thus relaxing the arteries.	Arginine	74-84	PCNA clamp associated factor	Rattus norvegicus	102-105
1388724-6	1992	DNA sequence analysis of beta ig-h3 indicated that it encoded a novel protein, beta IG-H3, of 683 amino acids, which contained an amino-terminal secretory sequence and a carboxy-terminal Arg-Gly-Asp (RGD) sequence that can serve as a ligand recognition site for several integrins.	Arginine	187-190	transforming growth factor beta induced	Homo sapiens	25-35
1388724-6	1992	DNA sequence analysis of beta ig-h3 indicated that it encoded a novel protein, beta IG-H3, of 683 amino acids, which contained an amino-terminal secretory sequence and a carboxy-terminal Arg-Gly-Asp (RGD) sequence that can serve as a ligand recognition site for several integrins.	Arginine	187-190	transforming growth factor beta induced	Homo sapiens	79-89
1499868-3	1992	To determine the effect of a reduced islet mass on these factors, we measured the acute insulin response to arginine (AIRa) and glucose (AIRg), the slope of glycemic potentiation of AIRa (SP), insulin sensitivity (Sl), and glucose effectiveness (SG) in control (CN), diabetic (DM), and pancreatectomized dogs rendered normoglycemic with transplanted autografts of islets of Langerhans (TX).	Arginine	108-116	insulin	Canis lupus familiaris	88-95
1518046-0	1992	Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA.	Arginine	99-107	coagulation factor II, thrombin	Bos taurus	48-56
1518046-0	1992	Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA.	Arginine	99-107	coagulation factor II, thrombin	Bos taurus	114-122
1644835-6	1992	Compared with the wild type (WT) apoA-I, the relative activation of LCAT achieved by the point mutations Gln-1, Gln-2----Arg,Arg, Pro99----His, and Pro121----His were 106 +/- 7, 92 +/- 6, and 77 +/- 9%, respectively.	Arginine	121-124	lecithin-cholesterol acyltransferase	Homo sapiens	68-72
1417895-6	1992	However the mutant protein is cleaved by OmpT between arginine 279 and alanine 280, which is a novel sequence specificity for this protease.	Arginine	54-62	outer membrane protease	Escherichia coli	41-45
1639060-4	1992	In the present study we have performed binding studies between protein 4.1 and AE1 using peptides and corresponding idiotypic and anti-idiotypic antibodies to show that arginine-rich clusters of the cytoplasmic domain of AE1 (IRRRY/LRRRY) serve as a major binding site for a motif with opposite charge and identical hydrophobicity present on the membrane-binding domain of protein 4.1 (LEEDY).	Arginine	169-177	erythrocyte membrane protein band 4.1	Homo sapiens	63-74
1639060-4	1992	In the present study we have performed binding studies between protein 4.1 and AE1 using peptides and corresponding idiotypic and anti-idiotypic antibodies to show that arginine-rich clusters of the cytoplasmic domain of AE1 (IRRRY/LRRRY) serve as a major binding site for a motif with opposite charge and identical hydrophobicity present on the membrane-binding domain of protein 4.1 (LEEDY).	Arginine	169-177	erythrocyte membrane protein band 4.1	Homo sapiens	373-384
1325029-9	1992	We conclude that the intrinsic biological activity of the thrombin receptor-derived peptide resides in the pentapeptide TRP42-46 and that the phenylalanine and arginine residues at positions 43 and 46 play key roles in the activity of this pentapeptide in smooth muscle systems.	Arginine	160-168	coagulation factor II (thrombin) receptor	Rattus norvegicus	58-75
1488751-8	1992	It is concluded from the present study that the N-terminal peptides of glucagon stimulate insulin release especially during the arginine infusion.	Arginine	128-136	insulin	Canis lupus familiaris	90-97
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Arginine	130-133	kallikrein related peptidase 4	Homo sapiens	4-14
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Arginine	148-151	kallikrein related peptidase 4	Homo sapiens	4-14
1535355-5	1992	The kallikrein cleavage points that provided 112 kd and 102 kd two-chain high molecular weight kininogen were after residues 437 (Arg-Lys) and 389 (Arg-Ser), whereas those for plasmin were after 438 (Lys-His) and 389 (Arg-Ser).	Arginine	148-151	kallikrein related peptidase 4	Homo sapiens	4-14
1599477-1	1992	This study demonstrates the presence of boc-Gln-Arg-Arg-MCA cleaving activity in bovine chromaffin granule membranes that resembles yeast Kex2 proteolytic activity.	Arginine	48-51	kexin KEX2	Saccharomyces cerevisiae S288C	138-142
1599477-1	1992	This study demonstrates the presence of boc-Gln-Arg-Arg-MCA cleaving activity in bovine chromaffin granule membranes that resembles yeast Kex2 proteolytic activity.	Arginine	52-55	kexin KEX2	Saccharomyces cerevisiae S288C	138-142
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Arginine	31-34	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Arginine	35-38	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Arginine	35-38	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Arginine	35-38	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1599477-2	1992	The chromaffin granule boc-Gln-Arg-Arg-MCA cleaving activity, like Kex2 proteolytic activity, shows calcium dependence, optimum activity at pH 7.5-8.2, inhibition by serine protease inhibitors, and preference for cleavage at the COOH-terminal side of Arg-Arg and Lys-Arg, over Lys-Lys, paired basic residues.	Arginine	35-38	kexin KEX2	Saccharomyces cerevisiae S288C	67-71
1378964-6	1992	(2) In S2, arginine and glycine were better substrates for GAA synthesis than canavanine and glycine.	Arginine	11-19	alpha glucosidase	Rattus norvegicus	59-62
1566827-2	1992	PRL approximately doubles the rate of uptake of alpha-aminoisobutyrate (AIB), arginine, and hydroxyproline but has no effect on the intracellular accumulation of unincorporated leucine.	Arginine	78-86	prolactin	Mus musculus	0-3
1593773-4	1992	Although tissue kallikrein was not demonstrable in the tunicae muscularis and serosa, inactive tissue kallikrein in the tunicae mucosa and submucosa reached 79.6% with s-ELISA and 99.1% with H-Pro-Phe-Arg-MCA.	Arginine	201-204	kallikrein 1-related peptidase C12	Rattus norvegicus	95-112
1372103-6	1992	The fourth mutation was a nucleotide transversion altering the His-244 codon (CAT) to an Arg codon (CGT) in XP8LO, an intermediate subgroup.	Arginine	89-92	UDP glycosyltransferase 8	Homo sapiens	100-103
1630593-2	1992	The responses of single dorsal horn neurones to electrically-evoked A beta fibre and C fibre inputs were reduced by topical application (directly onto the spinal cord) of both the nitric oxide inhibitor, nitro-L-arginine methyl ester (L-NAME; 500-1500 micrograms) and the precursor of nitric oxide, L-arginine (4500 micrograms).	Arginine	210-220	amyloid beta precursor protein	Rattus norvegicus	68-74
1537334-5	1992	We show that the TRP-2 of slaty mice has a single amino acid difference from wild-type TRP-2; a substitution of glutamine for arginine in the first copper binding site.	Arginine	126-134	dopachrome tautomerase	Mus musculus	17-22
1537334-5	1992	We show that the TRP-2 of slaty mice has a single amino acid difference from wild-type TRP-2; a substitution of glutamine for arginine in the first copper binding site.	Arginine	126-134	dopachrome tautomerase	Mus musculus	26-31
1729374-0	1992	IFN-gamma-induced L-arginine-dependent toxoplasmastatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-alpha.	Arginine	18-28	SAM domain and HD domain, 1	Mus musculus	0-17
1355075-14	1992	The percentage of all GFAP(+) cells that were positive for uptake of ARG varied from 50% to 90% and also showed differences in grain density both intra- and inter-regionally.	Arginine	69-72	glial fibrillary acidic protein	Rattus norvegicus	22-26
1487420-3	1992	The second variant was identical to Hb Sherwood Forest or alpha 2 beta 2(104)(G6)Arg-->Thr; it is believed that this may be the second observation of this abnormal hemoglobin.	Arginine	81-84	hemoglobin subunit gamma 2	Homo sapiens	155-174
1371576-3	1992	We studied the effect of GAL (80 pmol/kg/min infused over 60 minutes) on the arginine- (ARG, 30 g infused over 30 minutes) stimulated GH, PRL, insulin, and C-peptide secretion in eight healthy volunteers (age, 20 to 30 years).	Arginine	77-85	galanin and GMAP prepropeptide	Homo sapiens	25-28
1371576-5	1992	GAL enhanced the ARG-induced stimulation of both GH (1,634.1 +/- 293.1 v 566.9 +/- 144.0 micrograms/L/h, P less than .02) and PRL secretion (1,541.9 +/- 248.8 v 1,023.8 +/- 158.7 micrograms/L/h, P less than .02).	Arginine	17-20	galanin and GMAP prepropeptide	Homo sapiens	0-3
1371576-6	1992	On the contrary, GAL blunted the ARG-stimulated insulin (816.3 +/- 87.7 v 1,322.7 +/- 240.9 mU/L/h, P less than .05), as well as C-peptide secretion (105.1 +/- 9.8 v 132.8 +/- 17.3 micrograms/L/h, P less than .02).	Arginine	33-36	galanin and GMAP prepropeptide	Homo sapiens	17-20
1371576-9	1992	In conclusion, these results show that in man GAL potentiates the GH response to ARG, suggesting that these drugs act at the hypothalamic level, at least in part, via different mechanisms.	Arginine	81-84	galanin and GMAP prepropeptide	Homo sapiens	46-49
1513807-4	1992	In the presence of 5.5 mM glucose, PYY (10(-9) M) did not modify basal insulin release but reduced the biphasic insulin response to arginine (10 mM).	Arginine	132-140	peptide YY	Rattus norvegicus	35-38
1765098-8	1991	The peptide was named PR-39 (proline-arginine-rich with a size of 39 residues).	Arginine	37-45	antibacterial protein PR-39	Sus scrofa	22-27
1662272-3	1991	L-Arginine derivatives, NG-methyl-L-arginine and NG-nitro-L-arginine also inhibited cyclic GMP responses to 10(-8) M ET-1 with IC50 values of 1.2 x 10(-6) M and 7.6 x 10(-8) M, respectively, and the inhibition was prevented with L-arginine.	Arginine	0-10	endothelin-1	Sus scrofa	117-121
1662272-3	1991	L-Arginine derivatives, NG-methyl-L-arginine and NG-nitro-L-arginine also inhibited cyclic GMP responses to 10(-8) M ET-1 with IC50 values of 1.2 x 10(-6) M and 7.6 x 10(-8) M, respectively, and the inhibition was prevented with L-arginine.	Arginine	34-44	endothelin-1	Sus scrofa	117-121
1662272-4	1991	These data strongly suggest that ET-1 stimulates formation of an endothelium-derived relaxing factor-like substance from L-arginine or a related endogenous material(s) in a Ca(++)-dependent fashion, which in turn activates soluble guanylate cyclase to elevate cellular cyclic GMP levels.	Arginine	121-131	endothelin-1	Sus scrofa	33-37
1939157-4	1991	A plausible sequence of proteolytic cleavages that could generate the 79-residue form of MGP would be a trypsin-like cleavage at Arg80-Arg81 or Arg81-Gly82 followed by carboxypeptidase B-like cleavage to remove COOH-terminal arginine(s).	Arginine	225-233	carboxypeptidase B1	Homo sapiens	168-186
1951709-5	1991	Arg-depleted kidneys had a lower absolute sodium (TNa, 75.7 +/- 8.8 vs. 107.9 +/- 6.0 mumol.min-1.g kidney wt-1) and glucose reabsorption (T glucose, 3.7 +/- 0.6 vs. 5.6 +/- 0.5 mumol.min-1.g kidney wt-1), corresponding to a lower sodium and glucose filtration.	Arginine	0-3	C-type lectin domain family 3, member B	Rattus norvegicus	50-53
1807008-5	1991	When arginine was infused, GLP-1 (7-20), (7-36), (7-37), and glucagon enhanced insulin release.	Arginine	5-13	insulin	Canis lupus familiaris	79-86
1681909-0	1991	Characterization of a basic transthyretin variant--TTR Arg 102--in the German population.	Arginine	55-58	transthyretin	Homo sapiens	28-41
1681909-0	1991	Characterization of a basic transthyretin variant--TTR Arg 102--in the German population.	Arginine	55-58	transthyretin	Homo sapiens	51-54
1930940-5	1991	The search for specific structural changes of the DQA and DQB genes has shown that susceptibility correlates with the absence of aspartic acid at position 57 on the DQ beta chain (DQ beta 57 Asp--) and/or the presence of arginine at position 52 on the DQ alpha chain (DQ alpha 52 Arg+).	Arginine	221-229	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	58-61
1930940-5	1991	The search for specific structural changes of the DQA and DQB genes has shown that susceptibility correlates with the absence of aspartic acid at position 57 on the DQ beta chain (DQ beta 57 Asp--) and/or the presence of arginine at position 52 on the DQ alpha chain (DQ alpha 52 Arg+).	Arginine	280-283	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	58-61
1663820-5	1991	The lead compound (Arg6,Cha8 ANF 6-15 Phe-Arg-Cys-NH2) is a tridecapeptide that integrates the C-terminal amino acids inside the disulfide ring.	Arginine	19-22	natriuretic peptide A	Rattus norvegicus	29-32
1799407-2	1991	Induction with nalidixic acid produces high yields of a fusion protein, NS1-FX-beta-globin, where NS1 represents 81 residues of a flu virus protein and FX represents a blood-clotting Factor Xa recognition sequence, Ile-Glu-Gly-Arg.	Arginine	227-230	influenza virus NS1A binding protein	Homo sapiens	72-75
1661902-5	1991	ARG revealed that specific ANP binding was distributed mainly over the renal cortex with the inner medulla next in frequency.	Arginine	0-3	natriuretic peptide A	Rattus norvegicus	27-30
2068071-9	1991	The variant COOH terminus ends with the dibasic sequence Arg-Lys that is apparently removed through stepwise cleavage by serum carboxypeptidase B to yield several forms of circulating albumin.	Arginine	57-60	carboxypeptidase B1	Homo sapiens	127-145
1943708-1	1991	Oligonucleotide-directed mutagenesis of ctxB was used to produce mutants of cholera toxin B subunit (CT-B) altered at residues Cys-9, Gly-33, Lys-34, Arg-35, Cys-86 and Trp-88.	Arginine	150-153	phosphate cytidylyltransferase 1B, choline	Homo sapiens	76-99
1645337-5	1991	A systematic analysis revealed that replacement of Asn-115, Arg-154, and Ile-158 of the PDGF B-chain with the corresponding A-chain amino acids led to a dramatic decrease in the affinity for the beta-receptor.	Arginine	60-63	platelet derived growth factor subunit B	Homo sapiens	88-94
1645337-7	1991	These data thus indicate that Asn-115, Arg-154, and Ile-158 are likely to be part of the active site of the PDGF B-chain.	Arginine	39-42	platelet derived growth factor subunit B	Homo sapiens	108-114
2018974-1	1991	Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) binds fibrinogen via recognition sequences such as Arg-Gly-Asp (RGD).	Arginine	99-102	integrin subunit alpha 2b	Homo sapiens	36-41
2009266-4	1991	However, the site of thrombin-catalyzed cleavage, which in other species consists of an Arg-Gly peptide bond, is instead an Arg-Ala bond in the chicken beta chain.	Arginine	88-91	coagulation factor II, thrombin	Gallus gallus	21-29
2009266-4	1991	However, the site of thrombin-catalyzed cleavage, which in other species consists of an Arg-Gly peptide bond, is instead an Arg-Ala bond in the chicken beta chain.	Arginine	124-127	coagulation factor II, thrombin	Gallus gallus	21-29
1903761-0	1991	A serine-to-arginine (AGT-to-CGT) mutation in codon 549 of the CFTR gene in an Italian patient with severe cystic fibrosis.	Arginine	12-20	UDP glycosyltransferase 8	Homo sapiens	29-32
1706724-6	1991	Interestingly, the NSR1 protein has two RNA recognition motifs, as well as an acidic NH2 terminus containing a series of serine clusters, and a basic COOH terminus containing arg-gly repeats.	Arginine	175-178	Nsr1p	Saccharomyces cerevisiae S288C	19-23
2005390-4	1991	In initial experiments, C57BL/6 mice were immunized with a synthetic peptide corresponding to residues 5 through 16 of p21 containing the transforming substitution of arginine for normal glycine at residue 12.	Arginine	167-175	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	119-122
1910280-6	1991	Addition of 0.1 M arginine to the equilibration buffer led to elution of two-peaks, corresponding to the 65- and 63-kDa variants of one-chain tPA.	Arginine	18-26	chromosome 20 open reading frame 181	Homo sapiens	142-145
1910280-7	1991	Two-chain tPA remained bound to the column, but could be eluted with sodium acetate buffer, pH 4.0, containing 0.1 M arginine.	Arginine	117-125	chromosome 20 open reading frame 181	Homo sapiens	10-13
1846292-9	1991	Both IGF I receptor dimers and tetramers exhibit similar kinase activities using the synthetic substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, indicating that the failure to detect autophosphorylation of the IGF I receptor dimers does not result from inactivation of the kinase by DTT treatment.	Arginine	105-108	insulin like growth factor 1 receptor	Homo sapiens	5-19
1846292-9	1991	Both IGF I receptor dimers and tetramers exhibit similar kinase activities using the synthetic substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, indicating that the failure to detect autophosphorylation of the IGF I receptor dimers does not result from inactivation of the kinase by DTT treatment.	Arginine	105-108	insulin like growth factor 1 receptor	Homo sapiens	223-237
1846292-9	1991	Both IGF I receptor dimers and tetramers exhibit similar kinase activities using the synthetic substrate Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly, indicating that the failure to detect autophosphorylation of the IGF I receptor dimers does not result from inactivation of the kinase by DTT treatment.	Arginine	109-112	insulin like growth factor 1 receptor	Homo sapiens	5-19
1986788-1	1991	N-trifluoromethylcoumarinylamide derivatives of benzyloxycarbonyl-Arg-Arg, benzyloxycarbonyl-Phe-Arg and Arg are convenient chromogenic and fluorogenic substrates of cathepsin B, L and H, respectively.	Arginine	66-69	cathepsin B	Homo sapiens	166-177
1725346-0	1991	Endothelin-1 stimulates cyclic GMP formation in porcine kidney epithelial cells via activation of the L-arginine-dependent soluble guanylate cyclase pathway.	Arginine	102-112	endothelin-1	Sus scrofa	0-12
2277087-14	1990	We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands.	Arginine	92-95	CD47 molecule	Homo sapiens	20-23
2247846-6	1990	These mutations would result in amino acid substitutions of lysine, leucine, or arginine for the normal glutamine at position 61 in the N-ras protein.	Arginine	80-88	NRAS proto-oncogene, GTPase	Homo sapiens	136-141
2261483-3	1990	Direct examination of the formation and breakdown of the ES complex shows its formation occurs within milliseconds at 25 degrees C. The best heptapeptide substrate, Dns-Pro-Lys-Arg-Ala-Pro-Trp-Val, is cleaved only between the Arg-Ala (P1-P1") bond with kinetic parameters kcat = 380 s-1 and Km = 3.7 x 10(-4) M. The presence of Lys or Arg in the P1 and P2 positions yields high-turnover substrates.	Arginine	177-180	crystallin gamma F, pseudogene	Homo sapiens	346-355
2271648-3	1990	PSG9 and PSG10 are representatives of two distinct classes of PSG protein that have N-termini with or without the Arg-Gly-Asp motif implicated in adhesion.	Arginine	114-117	pregnancy specific beta-1-glycoprotein 10, pseudogene	Homo sapiens	9-14
2221580-8	1990	Consistent with these observations, smoke-treated CFI exhibited a decreased capacity to bind to GcG and a decreased capacity to inhibit the binding of C5a des Arg to GcG.	Arginine	159-162	complement factor I	Homo sapiens	50-53
2096887-5	1990	The added arginine tail could be specifically removed by carboxypeptidase B.	Arginine	10-18	carboxypeptidase B1	Homo sapiens	57-75
2121673-8	1990	These results indicate that CS1 peptide of fibronectin, lacking the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models.	Arginine	68-71	chorionic somatomammotropin hormone 1	Homo sapiens	28-31
2223838-0	1990	Functional modification of an arginine residue on salicylate hydroxylase.	Arginine	30-38	salicylate hydroxylase	Pseudomonas putida	50-72
1697312-11	1990	Although human C3ades Arg is inactive on guinea pig ileal and lung tissue, it binds to and induces degranulation of rat mast cells, as well as enhances vascular permeability in rat skin, at concentrations nearly identical to that of intact C3a.	Arginine	22-25	complement C3	Homo sapiens	15-18
2401659-5	1990	Studies indicated that for cathepsin B with Z-Arg-Arg-NMec as substrate, Km and Vmax values were .416 mM and 4,405 pmol.min-1.mg protein-1, respectively.	Arginine	46-49	cathepsin B	Homo sapiens	27-38
2116982-3	1990	Sequencing of the amino terminus of an A-like form of enzyme secreted by a kex2 mutant indicated the presence of 4 amino acids, with a pair of basic residues (Lys-Arg) at their carboxyl side, preceding the amino terminus of the wild-type external exoglucanase.	Arginine	163-166	kexin KEX2	Saccharomyces cerevisiae S288C	75-79
2358462-5	1990	However, M-ASGP-BP was characteristic in having a shorter cytoplasmic tail, and an inserted segment of 24 amino acids containing an Arg-Gly-Asp sequence between the membrane-spanning region and carbohydrate recognition domain.	Arginine	132-135	C-type lectin domain containing 10A	Rattus norvegicus	9-18
1693626-1	1990	Association of a novel beta 1-related subunit with alpha v. We report the isolation from two human neuroblastoma cell lines of an Arg-Gly-Asp-dependent integrin complex capable of binding to vitronectin, fibronectin, and type I collagen.	Arginine	130-133	vitronectin	Homo sapiens	191-202
2318854-3	1990	A point mutant (PKC alpha K----R) of PKC alpha, where Lys368 at the putative ATP-binding site is replaced with Arg, confers enhanced phorbol ester binding activity to both transiently and stably expressed COS and 3Y1 cells, respectively.	Arginine	111-114	protein kinase C, alpha	Rattus norvegicus	16-25
2318854-3	1990	A point mutant (PKC alpha K----R) of PKC alpha, where Lys368 at the putative ATP-binding site is replaced with Arg, confers enhanced phorbol ester binding activity to both transiently and stably expressed COS and 3Y1 cells, respectively.	Arginine	111-114	protein kinase C, alpha	Rattus norvegicus	37-46
2318983-5	1990	This report, based on extensive oligonucleotide dot blot hybridization of PCR-amplified DQA1 and DQB1 genes, reinforces the importance of the Asp57-negative DQ beta chain, but also introduces the possibility that a DQ alpha chain bearing an arginine in position 52 (Arg52) confers susceptibility to IDDM.	Arginine	241-249	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	97-101
1689763-2	1990	With truncated recombinant fusion proteins and synthetic peptides, a subset of anti-p68 autoantibodies was found to recognize the amino acid sequence motif Glu-Arg-Lys-Arg-Arg (ERKRR).	Arginine	160-163	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	84-87
1689763-2	1990	With truncated recombinant fusion proteins and synthetic peptides, a subset of anti-p68 autoantibodies was found to recognize the amino acid sequence motif Glu-Arg-Lys-Arg-Arg (ERKRR).	Arginine	168-171	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	84-87
1689763-2	1990	With truncated recombinant fusion proteins and synthetic peptides, a subset of anti-p68 autoantibodies was found to recognize the amino acid sequence motif Glu-Arg-Lys-Arg-Arg (ERKRR).	Arginine	168-171	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	84-87
2302223-3	1990	The potential heparin-binding site of IGF II is probably situated in the arginine-rich C-peptide region.	Arginine	73-81	insulin like growth factor 2	Bos taurus	38-44
2321910-6	1990	G6PD Montalbano is a new variant, with nearly normal properties, due to a G----A transition which causes an Arg----His amino acid replacement at position 285.	Arginine	108-111	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
2241479-0	1990	[The effect of intravenous administration of arginine and glycine on the blood plasma content of glucose, insulin, free fatty acids and total alpha-amino-N-compounds in lambs of different ages].	Arginine	45-53	LOC105613195	Ovis aries	106-113
2241479-8	1990	of glycin proved less effective than that of arginine with regard to higher levels of insulin and total alpha-amino-N.	Arginine	45-53	LOC105613195	Ovis aries	86-93
2136554-7	1990	On the basis of data from the literature regarding the tertiary structure of the trypsin-BPTI complex, we concluded that the secondary binding site of trypsin is plausibly identified as the same site in trypsin that binds the Arg-17 residue of BPTI, i.e., Tyr-39 and Tyr-151 in bovine trypsin.	Arginine	226-229	spleen trypsin inhibitor I	Bos taurus	89-93
2136554-7	1990	On the basis of data from the literature regarding the tertiary structure of the trypsin-BPTI complex, we concluded that the secondary binding site of trypsin is plausibly identified as the same site in trypsin that binds the Arg-17 residue of BPTI, i.e., Tyr-39 and Tyr-151 in bovine trypsin.	Arginine	226-229	spleen trypsin inhibitor I	Bos taurus	244-248
2105927-15	1990	Compared with CON, ARG and ORN increased (P less than .05) mean somatotropin (STH) concentration (13.8 vs 16.9 and 18.4 ng/ml) and amplitude of STH pulses (9.8 vs 15.1 and 17.8 ng/ml), whereas CON and UREA were similar.	Arginine	19-22	somatotropin	Ovis aries	64-76
2314485-4	1990	The PAF- and acetylcholine (ACh)-induced relaxations of mesenteric artery were dependent on the presence of endothelium and were inhibited by either hydroquinone and methylene blue, which inhibit the action of endothelium-derived relaxing factor (EDRF), or L-canavanine, which inhibits the formation of nitric oxide from L-arginine.	Arginine	321-331	PCNA clamp associated factor	Rattus norvegicus	4-7
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	156-166	arginase 2	Homo sapiens	106-116
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	156-166	arginase 2	Homo sapiens	118-122
33232463-2	2021	OBJECTIVES: We aimed to study whether single nucleotide polymorphisms (SNPs) in the arginase 1 (ARG1) and arginase 2 (ARG2) genes are associated with blood l-arginine concentrations in unsupplemented and l-arginine-supplemented individuals.	Arginine	204-214	arginase 2	Homo sapiens	118-122
33811140-3	2021	This releases U1-70K from subnuclear granules facilitating interaction with U1 snRNP and the serine-arginine (SR) protein SRSF1, critical steps in establishing the 5" splice site.	Arginine	100-108	serine and arginine rich splicing factor 1	Homo sapiens	122-127
33766222-0	2021	Ptpn22 Arg>Trp Polymorphism Improves Macrophage-Mediated Adipocyte Homeostasis.	Arginine	7-10	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	0-6
30354839-4	2018	PRMT1 catalyzes the arginine methylation of Fused in Sarcoma (FUS), an RNA-binding protein that interacts with RALY.	Arginine	20-28	protein arginine methyltransferase 1	Homo sapiens	0-5
28902392-1	2018	Protein arginine methyltransferase 7 (PRMT7) is a member of a family of enzymes that catalyze the transfer of methyl groups from S-adenosyl-l-methionine to nitrogen atoms on arginine residues.	Arginine	8-16	protein arginine methyltransferase 7	Homo sapiens	38-43
29261001-3	2018	In this study, we show that SQSTM1 is an N-recognin whose ZZ domain binds N-terminal arginine (Nt-Arg) and other N-degrons (Nt-Lys, Nt-His, Nt-Trp, Nt-Phe, and Nt-Tyr) of the N-end rule pathway.	Arginine	85-93	sequestosome 1	Homo sapiens	28-34
29261001-5	2018	Upon N-end rule interaction with the Nt-Arg of arginylated HSPA5 (R-HSPA5), SQSTM1 undergoes self-polymerization via disulfide bonds of Cys residues including Cys113, facilitating cargo collection.	Arginine	40-43	sequestosome 1	Homo sapiens	76-82
24992184-11	2014	CONCLUSIONS: This meta-analysis implied that the beta2-adrenoceptor Arg/Gly16 polymorphism was likely to contribute to asthma risk in Asian population.	Arginine	68-71	adrenoceptor beta 2	Homo sapiens	49-67
1695013-5	1990	The anti-aggregatory action of L-arginine is potentiated by prostacyclin and by M&amp;B22948, a selective inhibitor of the cyclic GMP phosphodiesterase, but not by HL725, a selective inhibitor of the cyclic AMP phosphodiesterase.	Arginine	31-41	5'-nucleotidase, cytosolic II	Homo sapiens	130-133
1695013-7	1990	L-Arginine stimulates the soluble guanylate cyclase and increases cyclic GMP in platelet cytosol.	Arginine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	73-76
34661851-11	2022	Knockdown of VDAC1 potentiated the protective effects of miR-7a-5p against H/R-induced cell injury.	Arginine	77-78	voltage-dependent anion channel 1	Rattus norvegicus	13-18
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	3-11	ligase I, DNA, ATP-dependent L homeolog	Xenopus laevis	76-80
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	28-31	ligase I, DNA, ATP-dependent L homeolog	Xenopus laevis	76-80
34801826-7	2021	An arginine binding cavity (Arg-binding cavity) of the TTD is essential for LIG1 interaction, thus the development of inhibitors that target the Arg-binding cavity could potentially repress UHRF1 function in cancer cells.	Arginine	145-148	ligase I, DNA, ATP-dependent L homeolog	Xenopus laevis	76-80
34854557-2	2022	Here we describe two families with an ultrarare ACVR1 gain-of-function pathogenic variant (codon 375, Arginine > Proline; ACVR1R375P ) responsible for a mild nonclassic fibrodysplasia ossificans progressiva (FOP) phenotype.	Arginine	102-110	activin A receptor type 1	Homo sapiens	48-53
34848745-10	2021	Key arginine residues at positions 57, 58 and 68 of GRIM-19 are mainly involved in the hydrogen-bonded interactions.	Arginine	4-12	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	52-59
34848745-11	2021	An intriguing feature of these arginine residues is that these display a consistent interaction pattern across unphosphorylated and phosphorylated monomers as well as unphosphorylated dimers in STAT3alpha-GRIM-19 complexes.	Arginine	31-39	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	205-212
34848745-13	2021	Analysing the binding affinity and stability through free energy changes upon mutation, we found GRIM-19 mutations Y33P and Q61L and among GRIM-19 arginines, R68P and R57M, to be one of the top-most major and minor disruptors of binding, respectively.	Arginine	147-156	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	139-146
34739238-1	2021	We report an observation of spin-orbit excited dipole-bound states (DBSs) in arginine-iodide complexes (Arg I-) by using temperature-dependent, wavelength-resolved "iodide-tagging" negative ion photoelectron spectroscopy.	Arginine	104-107	spindlin 1	Homo sapiens	28-32
34739238-2	2021	The observed DBSs are bound to the spin-orbit excited I(2P1/2) level of the neutral Arg I complex in zwitterionic conformations and identified based on the resonant enhancement due to spin-orbit electronic autodetachment from the I(2P1/2) DBS to the I(2P3/2) neutral ground state.	Arginine	84-87	spindlin 1	Homo sapiens	35-39
34739238-2	2021	The observed DBSs are bound to the spin-orbit excited I(2P1/2) level of the neutral Arg I complex in zwitterionic conformations and identified based on the resonant enhancement due to spin-orbit electronic autodetachment from the I(2P1/2) DBS to the I(2P3/2) neutral ground state.	Arginine	84-87	spindlin 1	Homo sapiens	184-188
34752483-5	2021	Biochemical analysis revealed that the CpAM-resistant mutations in the context of precore protein (p25) did not affect the levels of p22 produced by signal peptidase removal of N-terminal 19 amino acid residues, but significantly reduced p17, which is produced by furin cleavage of C-terminal arginine-rich domain of p22 and secreted as HBeAg.	Arginine	293-301	tubulin polymerization promoting protein	Homo sapiens	99-102
34673031-3	2021	Previously, we showed that dephosphorylation of the splicing factor SRSF2 regulated increased interactions with similar arginine-rich RBPs U1-70K and LUC7L3.	Arginine	120-128	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	150-156
34673031-12	2021	Collectively, these findings demonstrate that phosphorylation may be a critical modification that prevents arginine-rich RBP insolubility and oligomerization.	Arginine	107-115	retinol binding protein 4	Homo sapiens	121-124
34583098-0	2021	Arginine methylation by PRMT2 promotes IFN-beta production through TLR4/IRF3 signaling pathway.	Arginine	0-8	protein arginine methyltransferase 2	Homo sapiens	24-29
34583098-3	2021	In this study, we found that protein arginine methyltransferase 1, 2 and 3 (PRMT1, 2 and 3) were recruited to methylate TLR4-CD (cytoplasmic domain) after lipopolysaccharide (LPS) stimulation respectively, but the effect of PRMT2 on arginine methylation of TLR4-CD is the most significant among above three PRMTs, which prompted us to focus on PRMT2.	Arginine	233-241	protein arginine methyltransferase 1	Homo sapiens	29-74
34583098-3	2021	In this study, we found that protein arginine methyltransferase 1, 2 and 3 (PRMT1, 2 and 3) were recruited to methylate TLR4-CD (cytoplasmic domain) after lipopolysaccharide (LPS) stimulation respectively, but the effect of PRMT2 on arginine methylation of TLR4-CD is the most significant among above three PRMTs, which prompted us to focus on PRMT2.	Arginine	233-241	protein arginine methyltransferase 1	Homo sapiens	76-90
34583098-3	2021	In this study, we found that protein arginine methyltransferase 1, 2 and 3 (PRMT1, 2 and 3) were recruited to methylate TLR4-CD (cytoplasmic domain) after lipopolysaccharide (LPS) stimulation respectively, but the effect of PRMT2 on arginine methylation of TLR4-CD is the most significant among above three PRMTs, which prompted us to focus on PRMT2.	Arginine	233-241	protein arginine methyltransferase 2	Homo sapiens	224-229
34583098-4	2021	Reduction of PRMT2 expression down-regulated arginine (R) methylation level of TLR4 with or without LPS treatment.	Arginine	45-53	protein arginine methyltransferase 2	Homo sapiens	13-18
34583098-5	2021	Methionine 115 (M115) mediated PRMT2 catalyzed-arginine methylation of TLR4 on R731 and R812.	Arginine	47-55	protein arginine methyltransferase 2	Homo sapiens	31-36
34583098-6	2021	Furthermore, PRMT1, 2 and 3 was recruited to methylate interferon regulatory factor 3 (IRF3) after LPS stimulation respectively, but the effect of PRMT2 on arginine methylation of IRF3 is the most significant among the above three PRMTs.	Arginine	156-164	protein arginine methyltransferase 1	Homo sapiens	13-27
34583098-6	2021	Furthermore, PRMT1, 2 and 3 was recruited to methylate interferon regulatory factor 3 (IRF3) after LPS stimulation respectively, but the effect of PRMT2 on arginine methylation of IRF3 is the most significant among the above three PRMTs.	Arginine	156-164	protein arginine methyltransferase 2	Homo sapiens	147-152
34583098-9	2021	In addition, the enhancement of arginine methylation of TLR4 induced by PRMT1 or 2 increased IRF3 transcription activity with or without LPS treatment, while PRMT2 with histidine 112 glutamine (H112Q) or methionine 115 isoleucine (M115I) mutation and TLR4 with arginine 812 lysine (R812K) mutation decreased it.	Arginine	32-40	protein arginine methyltransferase 1	Homo sapiens	72-77
34583098-9	2021	In addition, the enhancement of arginine methylation of TLR4 induced by PRMT1 or 2 increased IRF3 transcription activity with or without LPS treatment, while PRMT2 with histidine 112 glutamine (H112Q) or methionine 115 isoleucine (M115I) mutation and TLR4 with arginine 812 lysine (R812K) mutation decreased it.	Arginine	32-40	protein arginine methyltransferase 2	Homo sapiens	158-163
34833023-1	2021	PRMT1, the major protein arginine methyltransferase in mammals, catalyzes monomethylation and asymmetric dimethylation of arginine side chains in proteins.	Arginine	25-33	protein arginine methyltransferase 1	Homo sapiens	0-5
34833023-1	2021	PRMT1, the major protein arginine methyltransferase in mammals, catalyzes monomethylation and asymmetric dimethylation of arginine side chains in proteins.	Arginine	122-130	protein arginine methyltransferase 1	Homo sapiens	0-5
34957512-7	2021	Serine and Arginine Rich Splicing Factor 2 was implicated in 37.2% of potentially pathogenic events, including Exon5 exclusion in HLA-DMB.	Arginine	11-19	serine and arginine rich splicing factor 1	Homo sapiens	25-42
34346710-3	2021	Previous studies using Clostridium botulinum strain ATCC 3502 revealed that high levels of arginine (20 g/liter) repressed BoNT production approximately 1,000-fold.	Arginine	91-99	botulinum neurotoxin type B	Clostridium botulinum	123-127
34184805-5	2021	Mechanistically, LOC113230 acts as a scaffold to facilitate recruiting LRPPRC and the TRAF2 E3 ubiquitin ligase to ASS1, resulting in enhanced ubiquitination and degradation of ASS1 and decreased arginine synthesis.	Arginine	196-204	leucine rich pentatricopeptide repeat containing	Homo sapiens	71-77
34184805-5	2021	Mechanistically, LOC113230 acts as a scaffold to facilitate recruiting LRPPRC and the TRAF2 E3 ubiquitin ligase to ASS1, resulting in enhanced ubiquitination and degradation of ASS1 and decreased arginine synthesis.	Arginine	196-204	TNF receptor associated factor 2	Homo sapiens	86-91
34184805-7	2021	Collectively, these findings suggest that TGF-beta and Snail promote arginine synthesis via inhibiting LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly and this complex can serve as potential target for the development of new therapeutic approaches to treat CRC.	Arginine	69-77	leucine rich pentatricopeptide repeat containing	Homo sapiens	122-128
34184805-7	2021	Collectively, these findings suggest that TGF-beta and Snail promote arginine synthesis via inhibiting LOC113230-mediated LRPPRC/TRAF2/ASS1 complex assembly and this complex can serve as potential target for the development of new therapeutic approaches to treat CRC.	Arginine	69-77	TNF receptor associated factor 2	Homo sapiens	129-134
34180478-3	2021	In this paper, we report an siRNA delivery strategy targeting the oncogene KRAS based on arginine-modified poly(disulfide amine)/siRNA nanocomplexes.	Arginine	89-97	KRAS proto-oncogene, GTPase	Homo sapiens	75-79
34308797-1	2021	Human PRMT4, also known as CARM1, is a type I arginine methyltransferase protein that catalyse the formation of asymmetrical dimethyl arginine product.	Arginine	134-142	coactivator associated arginine methyltransferase 1	Homo sapiens	6-11
34308797-1	2021	Human PRMT4, also known as CARM1, is a type I arginine methyltransferase protein that catalyse the formation of asymmetrical dimethyl arginine product.	Arginine	134-142	coactivator associated arginine methyltransferase 1	Homo sapiens	27-32
34292156-0	2021	Retraction: Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.	Arginine	12-20	protein arginine methyltransferase 7	Homo sapiens	46-51
34359242-8	2021	However, compared with controls, increased Met or Arg supply attenuated the downregulation of BCKDK induced by Ce.	Arginine	50-53	branched chain keto acid dehydrogenase kinase	Bos taurus	94-99
34356607-2	2021	Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites of HSP47 on native collagens are not fully defined.	Arginine	67-70	serpin family H member 1	Homo sapiens	33-38
34356607-2	2021	Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites of HSP47 on native collagens are not fully defined.	Arginine	67-70	serpin family H member 1	Homo sapiens	175-180
34277626-5	2021	After LASSO and Cox regression analyses, a six ARG-based signature (APOC3, EPOR, H2AFX, MXD1, PLCG2, and YWHAZ) was constructed using TCGA dataset that significantly stratified cases into high- and low-risk groups in terms of overall survival (OS).	Arginine	47-50	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	105-110
34145242-4	2021	We find by mass spectrometry that METTL14 arginine 255 (R255) is methylated (R255me).	Arginine	42-50	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	34-41
34204776-2	2021	The amino acid substitution of Arg for Pro residue in the 90th position (R90P) in gamma-tropomyosin (Tpm3.12) is associated with congenital fiber type disproportion and muscle weakness.	Arginine	31-34	tropomyosin 3	Homo sapiens	101-105
34616867-2	2021	PADI1 and PADI3 catalyze citrullination of arginine 106 in the glycolytic enzyme pyruvate kinase M2 modulating its allosteric regulation, glycolysis and cancer cell proliferation.	Arginine	43-51	peptidyl arginine deiminase 3	Homo sapiens	10-15
34064498-5	2021	Docking and molecular dynamics simulations explain this specificity at the level of the NADPH site of NOX and NOS, where conserved arginine residues distinguished between the 2"-phosphate over the 3"-phosphate group, in favor of the 2"-phosphate.	Arginine	131-139	2,4-dienoyl-CoA reductase 1	Homo sapiens	88-93
34251640-1	2021	Arginine is a key amino acid in pregnant females as it is the precursor for nitric oxide (NO) via nitric oxide synthase and for polyamines (putrescine, spermidine, and spermine) by either arginase II and ornithine decarboxylase to putrescine or via arginine decarboxylase to agmatine and agmatine to putrescine via agmatinase.	Arginine	0-8	ornithine decarboxylase, structural 1	Mus musculus	204-227
34278875-10	2021	CONCLUSION: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians.	Arginine	91-94	X-ray repair cross complementing 1	Homo sapiens	65-70
34278875-10	2021	CONCLUSION: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians.	Arginine	103-106	X-ray repair cross complementing 1	Homo sapiens	65-70
34278875-10	2021	CONCLUSION: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians.	Arginine	107-110	X-ray repair cross complementing 1	Homo sapiens	65-70
34278875-10	2021	CONCLUSION: The results from this meta-analysis suggest that the XRCC1 Arg399Gln variants (Arg/Gln and Arg/Arg+Arg/Gln) may contribute to high HNC risk among Caucasians.	Arginine	111-114	X-ray repair cross complementing 1	Homo sapiens	65-70
34725288-5	2021	RESULTS: Results: Pregnant women with preeclampsia showed the imbalance between pro- and anti-inflammatory cytokines in favour of TNF-alpha and INF-gamma under the decrease in IL-10 that results in an imbalance in the activity of enzymes regulating L-arginine metabolism, with increased iNOS activity and decreased arginine activity.	Arginine	249-259	interleukin 10	Homo sapiens	176-181
34725288-5	2021	RESULTS: Results: Pregnant women with preeclampsia showed the imbalance between pro- and anti-inflammatory cytokines in favour of TNF-alpha and INF-gamma under the decrease in IL-10 that results in an imbalance in the activity of enzymes regulating L-arginine metabolism, with increased iNOS activity and decreased arginine activity.	Arginine	315-323	interleukin 10	Homo sapiens	176-181
35608157-5	2022	Simulations of wild-type PDZ and arginine mutants suggest that contacts with Arg79/85 in hPTP1E/MAGI1 are more important for the EQVEAV peptide than for EQVSAV.	Arginine	33-41	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	89-95
35532794-6	2022	UUO-treated Trem-2-/- mice displayed aggravated renal pathogenesis accompanied by greater neutrophil infiltration and enhanced Th17 cells differentiation, phenotypes that could be rescued by the administration of L-arginine (a biological precursor of NO).	Arginine	213-223	triggering receptor expressed on myeloid cells 2	Mus musculus	12-18
35532794-9	2022	KEY MESSAGES: The expression of TREM-2 is increased in nephritis TREM-2+ DCs maintain NO production to negatively regulate Th17 differentiation The severe pathologies of nephritis can be rescued by L-arginine supplementation.	Arginine	198-208	triggering receptor expressed on myeloid cells 2	Mus musculus	32-38
35532794-9	2022	KEY MESSAGES: The expression of TREM-2 is increased in nephritis TREM-2+ DCs maintain NO production to negatively regulate Th17 differentiation The severe pathologies of nephritis can be rescued by L-arginine supplementation.	Arginine	198-208	triggering receptor expressed on myeloid cells 2	Mus musculus	65-71
35618777-7	2022	In silico analysis of an intronic duplication c.595-120_595-86dup revealed additional binding sites for Serine- and Arginine-rich Splicing Factors (SRSF), which is predicted to impair CLCN7 expression.	Arginine	116-124	chloride voltage-gated channel 7	Homo sapiens	184-189
35613513-9	2022	However, UGGT1R1526C and UGGT1WT interact with arginine similarly.	Arginine	47-55	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	25-30
35613513-10	2022	We identified several amino acid residues for the arginine and proinsulin interaction.	Arginine	50-58	insulin II	Mus musculus	63-73
35316752-2	2022	Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and played crucial roles in the regulation of tumor growth and metastasis through various mechanisms such as regulating L-arginine metabolism, influencing tumor immune microenvironment, etc.	Arginine	313-323	arginase 2	Homo sapiens	117-127
35316752-2	2022	Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and played crucial roles in the regulation of tumor growth and metastasis through various mechanisms such as regulating L-arginine metabolism, influencing tumor immune microenvironment, etc.	Arginine	313-323	arginase 2	Homo sapiens	129-133
35066566-17	2022	Taken together, our results show that the ROR/miR-185-5p/CDK6 axis modulates cell pyroptosis induced by H/R and the inflammatory response of HCMs.	Arginine	106-107	microRNA 185	Homo sapiens	46-53
35339936-5	2022	Arg supplementation linearly upregulated (P < 0.05) the gonadotropin-releasing hormone 1 (GnRH1), and gonadotropin inhibitory hormone in the hypothalamus.	Arginine	0-3	gonadotropin releasing hormone 1	Gallus gallus	56-88
35339936-5	2022	Arg supplementation linearly upregulated (P < 0.05) the gonadotropin-releasing hormone 1 (GnRH1), and gonadotropin inhibitory hormone in the hypothalamus.	Arginine	0-3	gonadotropin releasing hormone 1	Gallus gallus	90-95
35339936-7	2022	In the ovary, GnRH1, and estrogen receptor beta were linearly increased by Arg, and the ovarian morphology revealed that LCP induced structural alterations which were minimally recovered by Arg supplementation.	Arginine	75-78	gonadotropin releasing hormone 1	Gallus gallus	14-19
35339936-7	2022	In the ovary, GnRH1, and estrogen receptor beta were linearly increased by Arg, and the ovarian morphology revealed that LCP induced structural alterations which were minimally recovered by Arg supplementation.	Arginine	75-78	estrogen receptor 2	Gallus gallus	25-47
35339936-7	2022	In the ovary, GnRH1, and estrogen receptor beta were linearly increased by Arg, and the ovarian morphology revealed that LCP induced structural alterations which were minimally recovered by Arg supplementation.	Arginine	190-193	gonadotropin releasing hormone 1	Gallus gallus	14-19
35339936-7	2022	In the ovary, GnRH1, and estrogen receptor beta were linearly increased by Arg, and the ovarian morphology revealed that LCP induced structural alterations which were minimally recovered by Arg supplementation.	Arginine	190-193	estrogen receptor 2	Gallus gallus	25-47
35482954-3	2022	Here we report a deconstruction-reconstruction approach that, starting from a series of type I PRMT inhibitors previously identified by us, allowed for the identification of potent and selective inhibitors of PRMT4, which regardless of the low cell permeability show an evident reduction of arginine methylation levels in MCF7 cells and a marked reduction of proliferation.	Arginine	291-299	coactivator associated arginine methyltransferase 1	Homo sapiens	209-214
35468132-7	2022	To determine whether such proteins can serve as vaccine candidates, we focused on two enzymes, alpha-enolase (ENO) and ornithine carbamoyl transferase (OCT), which are involved in glycolysis and arginine metabolism, respectively.	Arginine	195-203	enolase 1, alpha non-neuron	Mus musculus	95-108
35567118-4	2022	The ORF5 (p10) protein sequence of eight Iranian isolates was compared to other vitiviruses, showing that the most conserved region resides in the N-terminus, carrying an arginine-rich motif followed by a zinc-finger motif.	Arginine	171-179	CWC15 spliceosome associated protein homolog	Homo sapiens	4-8
35422485-9	2022	In addition, exosomal miR-182-5p was found to diminish GSDMD-dependent cell pyroptosis and inflammation induced by H/R.	Arginine	117-118	gasdermin D	Mus musculus	55-60
35409362-0	2022	Protein Kinase C (Pkc)-delta Mediates Arginine-Induced Glucagon Secretion in Pancreatic alpha-Cells.	Arginine	38-46	protein kinase C, delta	Mus musculus	0-28
35409362-8	2022	Furthermore, we showed that arginine increased Pkcdelta phosphorylation at Thr505, which is critical for Pkcdelta activation.	Arginine	28-36	protein kinase C, delta	Mus musculus	47-55
35409362-8	2022	Furthermore, we showed that arginine increased Pkcdelta phosphorylation at Thr505, which is critical for Pkcdelta activation.	Arginine	28-36	protein kinase C, delta	Mus musculus	105-113
35409362-9	2022	Interestingly, the knockdown of Pkcdelta in InR1G9 cells reduced arginine-induced glucagon secretion.	Arginine	65-73	protein kinase C, delta	Mus musculus	32-40
35409362-11	2022	Pkcdelta is essential for arginine-induced glucagon secretion in pancreatic alpha-cells.	Arginine	26-34	protein kinase C, delta	Mus musculus	0-8
35220691-2	2022	Coactivator-associated arginine methyltransferase (Carm1, also known as Prmt4) participates in various cellular events, such as cell survival, proliferation, and differentiation through its protein arginine methylation activities.	Arginine	198-206	coactivator associated arginine methyltransferase 1	Homo sapiens	51-56
35124853-4	2022	For instance, ADP-ribosyltransferase 1 (ART1) catalyzes mono(ADP-ribosyl)ation of arginine residues in Trim72, a protein specifically expressed in muscle cells and involved in cell membrane repair, which is enhanced upon its ADP-ribosylation.	Arginine	82-90	tripartite motif containing 72	Homo sapiens	103-109
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Arginine	51-54	glycine amidinotransferase	Homo sapiens	66-101
35352207-3	2022	In humans and animals, hArg is biosynthesized from Arg and Lys by arginine:glycine amidinotransferase (AGAT).	Arginine	51-54	glycine amidinotransferase	Homo sapiens	103-107
35306816-4	2022	Through the combination of the electrochemical and HRMS results, decreases in arginine and NO and increases in ADMA and ornithine were observed after modulation by CK, and two highly correlated metabolic pathways including arginine and proline metabolism and vascular smooth muscle contraction were found.	Arginine	78-86	cytidine/uridine monophosphate kinase 1	Homo sapiens	164-166
35306816-4	2022	Through the combination of the electrochemical and HRMS results, decreases in arginine and NO and increases in ADMA and ornithine were observed after modulation by CK, and two highly correlated metabolic pathways including arginine and proline metabolism and vascular smooth muscle contraction were found.	Arginine	223-231	cytidine/uridine monophosphate kinase 1	Homo sapiens	164-166
35300428-7	2022	A five ARG-based signature, including A2M, CHEK2, ELN, FOS, and PLAU, was constructed in the TCGA dataset, and stratified patients into low- and high-risk groups with significantly different overall survival (OS) rates.	Arginine	7-10	elastin	Homo sapiens	50-53
35300428-7	2022	A five ARG-based signature, including A2M, CHEK2, ELN, FOS, and PLAU, was constructed in the TCGA dataset, and stratified patients into low- and high-risk groups with significantly different overall survival (OS) rates.	Arginine	7-10	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-58
34967264-2	2022	This work intended to explore the functions of lncRNA SOX2-OT and its regulatory mechanism within MI/R-induced injury.	Arginine	101-102	SOX2 overlapping transcript	Homo sapiens	54-61
35372502-8	2022	SLC6A14 inhibition with a specific pharmacological blocker reduced 3H-arginine transport, mTOR phosphorylation, and bronchial epithelial repair rates in wound healing assays.	Arginine	70-78	solute carrier family 6 member 14	Homo sapiens	0-7